FedInvent™ Patents
Patent Details for Tuesday, July 04, 2006
This page was updated on Sunday, March 26, 2023 at 08:03 PM GMT
Department of Health and Human Services (HHS)
| US 07070398 | Olsen et al. |
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| ASSIGNEE(S) | Medforte Research Foundation (Salt Lake City, Utah) |
| INVENTOR(S) | Don B. Olsen (Salt Lake City, Utah); Paul E. Allaire (Charlottesville, Virginia); Houston G. Wood (Crozet, Virginia); Ronald Kipp (Willowstreet, Pennsylvania); Wei Jiang (Charlottesville, Virginia); Zongli Lin (Charlottesville, Virginia); Guoxin Li (Charlottesville, Virginia) |
| ABSTRACT | A blood pump has an impeller rotatably disposed and magnetically suspended within a cavity of a stator by a plurality of magnetic bearings including an axial bearing to support the impeller axially in the cavity. The axial bearing includes adjacent impeller magnets and adjacent stator magnets with axially aligned polarities and reverse polarities with respect to adjacent magnets. A motor includes impeller magnets on the impeller and coils and poles associated with the stator. Radial permanent magnet and electromagnetic bearings are also included. The magnetic bearings and the motor have stator magnets or coils and poles disposed radially across the fluid passage from corresponding impeller magnets to define an annular gap positioned radially between the impeller and the stator, and positioned radially between all of the plurality of magnetic bearings, creating a straight through blood path without secondary flow paths. |
| FILED | Friday, September 24, 2004 |
| APPL NO | 10/949884 |
| ART UNIT | 3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Pumps 417/353 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070565 | Vaezy et al. |
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| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Shahram Vaezy (Seattle, Washington); Adrian Prokop (Lynnwood, Washington); Roy W. Martin (Anacortes, Washington); Peter Kaczkowski (Seattle, Washington); Misty Noble (Seattle, Washington) |
| ABSTRACT | The present invention employs hydrogels as acoustic couplings for clinical applications of ultrasound imaging and therapy, but is particularly applicable to high intensity focused ultrasound (HIFU) based therapy. While other materials can be used, it has been determined that polyacrylamide is sufficiently robust and transmissive to withstand the high temperatures encountered in HIFU therapy. One embodiment of a hydrogel coupling is configured in shape and size (length) to ensure that a focal region of an ultrasound transducer is disposed proximate the target area when the distal tip of the transducer is in contact with tissue. These couplings can be shaped to correspond to the beam focus characteristics of specific transducers. Water can be applied to hydrate the tip of the hydrogel coupling during use, and medication absorbed into the hydrogel material can be applied to the tissue in contact with the distal surface of the hydrogel. |
| FILED | Friday, May 30, 2003 |
| APPL NO | 10/449819 |
| ART UNIT | 3737 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Surgery 6/459 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070592 | Santini, Jr. et al. |
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| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | John T. Santini, Jr. (Belmont, Massachusetts); Michael J. Cima (Winchester, Massachusetts); Robert S. Langer (Newton, Massachusetts) |
| ABSTRACT | Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the plurality reservoirs; control circuitry for selectively disintegrating or permeabilizing the reservoir cap over a reservoir opening; and, optionally, a diagnostic reagent in the reservoirs. Devices also are provided for the controlled delivery of molecules comprising a substrate; an array of reservoirs; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate inside the reservoirs or to a surface outside of the reservoirs, wherein the electrodes are not reservoir caps; and means for applying an electric current or potential across the electrodes effective to activate release of the molecules from the reservoirs. The devices can be adapted for implantation for in vivo diagnostics or drug delivery. |
| FILED | Wednesday, July 07, 2004 |
| APPL NO | 10/886405 |
| ART UNIT | 3767 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Surgery 64/891.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070739 | Anderson et al. |
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| ASSIGNEE(S) | Large Scale Proteomics Corporation (Vacaville, California) |
| INVENTOR(S) | Norman G. Anderson (Rockville, Maryland); N. Leigh Anderson (Washington, District of Columbia) |
| ABSTRACT | A method for separating microorganisms, especially infectious agents, from a mixture by two dimensional centrifugation on the basis of sedimentation rate and isopycnic banding density, for sedimenting such microorganisms through zones of immobilized reagents to which they are resistant, for detecting banded particles by light scatter or fluorescence using nucleic acid specific dyes, and for recovering the banded particles in very small volumes for characterization by mass spectrometry of viral protein subunits and intact viral particles, and by fluorescence flow cytometric determination of both nucleic acid mass and the masses of fragments produced by restriction enzymes. The method is based on the discovery that individual microorganisms, such as bacterial and viral species, are each physically relatively homogeneous, and are distinguishable in their biophysical properties from other biological particles, and from non-biological particles found in nature. The method is useful for distinguishing infections, for identifying known microorganisms, and for discovering and characterizing new microorganisms. The method provides very rapid identification of microorganisms, and hence allows a rational choice of therapy for identified infectious agents. A particularly useful application is in clinical trials of new antibiotics and antivirals, where it is essential to identify at the outset individuals infected with the targeted infectious agent. |
| FILED | Tuesday, May 16, 2000 |
| APPL NO | 09/571290 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing 422/82.50 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070771 | Kipps et al. |
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| ASSIGNEE(S) | Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Thomas J. Kipps (Solana Beach, California); Sanjai Sharma (La Jolla, California); Mark Cantwell (La Jolla, California) |
| ABSTRACT | This invention relates to genes which encode accessory molecule ligands, such as the CD40 ligand and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the accessory molecule ligands of this invention are also disclosed. |
| FILED | Monday, December 01, 1997 |
| APPL NO | 08/982272 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070777 | Lederman et al. |
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| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Seth Lederman (New York, New York); Leonard Chess (Scarsdale, New York); Michael J. Yellin (Riverdale, New York) |
| ABSTRACT | This invention provides for methods of inhibiting inflammation with antibodies that bind the 5c8 protein. |
| FILED | Wednesday, June 07, 1995 |
| APPL NO | 08/476649 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/154.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070780 | Steinman et al. |
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| ASSIGNEE(S) | Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Lawrence Steinman (Palo Alto, California); Pedro Jose Ruiz (Redwood City, California) |
| ABSTRACT | Compositions and methods are provided for the treatment of demyelinating autoimmune disease. Therapeutic doses are administered of an ordered peptide comprising a repeated motif {SEQ ID NO: 1} [1E2Y3Y4K]n, where n is from 2 to 6. Some specific peptides of interest include those having the sequence {SEQ ID NO:4} EYYKEYYKEYYK. The peptide may consist only of the ordered repeats, or may be extended at either termini by the addition of other amino acid residues. For therapy, the peptides may be administered topically or parenterally, e.g. by injection at a particular site, including subcutaneously, intraperitoneally, intravascularly, or the like or transdermally, as by electrotransport. In a preferred embodiment, subcutaneous injection is used to deliver the peptide. The subject methods are used for prophylactic or therapeutic purposes. The compositions of the invention may also contain other therapeutically active agents, e.g. immunosuppressants, β-interferon, steroids, etc. |
| FILED | Monday, May 20, 2002 |
| APPL NO | 10/152654 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/184.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070787 | Haynes et al. |
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| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Barton F. Haynes (Durham, North Carolina); Dhavalkumar D. Patel (Durham, North Carolina); Munir Alam (Chapel Hill, North Carolina); Hua-Xin Liao (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same. |
| FILED | Monday, August 25, 2003 |
| APPL NO | 10/646729 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/196.110 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070788 | Szkudlinski et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Mariusz W. Szkudlinski (Potomac, Maryland); Bruce D. Weintraub (Rockville, Maryland); Mathis Grossmann (Parkville, Australia) |
| ABSTRACT | The invention is directed toward a human glycoprotein hormone having at least one, two, three, four, or five basic amino acids in the α-subunit at positions selected from the group consisting of positions 11, 13, 14, 16, 17, and 20. The inventions is also directed to a human glycoprotein where at least one of the amino acids at position 58, 63, and 69 of the β-subunit of the human thyroid stimulating hormone are basic amino acids. The invention is further directed to a modified human glycoprotein hormone having increased activity over a wild-type human glycoprotein hormone, where the modified human glycoprotein comprises a basic amino acid substituted at a position corresponding to the same amino acid position in a non-human glycoprotein hormone having an increased activity over the wild-type human glycoprotein hormone. The invention is also directed to a method of constructing superactive nonchimeric analogs of human hormones comprising comparing the amino acid sequence of a more active homolog from another species to the human hormone, and selecting superactive analogs from the substituted human hormones. The invention is also directed to nucleic acids encoding the modified human glycoprotein hormones, vectors containing those nucleic acids, and host cells containing those vectors. |
| FILED | Friday, January 25, 2002 |
| APPL NO | 10/057113 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/198.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070790 | Bukh et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Jens Bukh (Bethesda, Maryland); Roger H. Miller (Rockville, Maryland); Robert H. Purcell (Boyds, Maryland) |
| ABSTRACT | The nucleotide and deduced amino acid sequences of cDNAs encoding the envelope 1 genes and core genes of isolates of hepatitis C virus (HCV) are disclosed. The invention relates to the oligonucleotides, peptides and recombinant envelope 1 and core proteins derived from these sequences and their use in diagnostic methods and vaccines. |
| FILED | Tuesday, May 26, 1998 |
| APPL NO | 09/084691 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/228.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070807 | Mixson |
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| INVENTOR(S) | A. James Mixson (Rockville, Maryland) |
| ABSTRACT | The invention provides a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport polymer comprising one or more backbones, one or more terminal branches, and optionally, one or more non-terminal branches. The branched transport polymer may be associated with a pharmaceutical agent to form a pharmaceutical agent delivery composition useful for in vivo therapies based on local injection. |
| FILED | Thursday, April 25, 2002 |
| APPL NO | 10/131909 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/484 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070939 | Montgomery et al. |
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| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Anthony Montgomery (San Diego, California); Paul Demarco (Wausau, Wisconsin); Fang Mei (League City, Texas) |
| ABSTRACT | This invention relates generally to the field of prognosis and diagnosis of vasculopathy and certain tumors. In particular, the invention provides a method for prognosing or diagnosing vasculopathy, neuroectodermal tumor, epithelial tumor, myelomonocytic tumor or lymphoid tumor in a mammal, which method comprises: a) assessing a NCAM L1 protein or a derivative or fragment thereof, or a mRNA encoding said NCAM L1 protein or a derivative or fragment thereof, in a mammal having or suspected of having vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor; b) assessing a NCAM L1 protein or a derivative or fragment thereof, or a mRNA encoding said NCAM L1 protein or a derivative or fragment thereof, in a mammal not having said vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor; c) comparing the presence or quantity of said NCAM L1 protein or mRNA assessed in steps a) and b), whereby said NCAM L1 protein or mRNA assessed in step a) is more than that assessed in step b) indicates the presence of said vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor in said mammal. The method can also be used for monitoring the effectiveness of the treatment of the vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor. |
| FILED | Wednesday, September 26, 2001 |
| APPL NO | 10/130085 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070941 | Zhao et al. |
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| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Yingming Zhao (Dallas, Texas); John R. Falck (University Park, Texas) |
| ABSTRACT | The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog substrates. Examples of such analogs are azido farnesyl diphosphate and azido farnesyl alcohol. The azido moiety in the resulting modified proteins provides an affinity tag, which can be chemoselectively captured by an azide-specific conjugation reaction, such as the Staudinger reaction, using a phosphine capture reagent. When the capture agent is biotinylated, the resulting conjugates can be detected and affinity-purified by streptavidin-linked- HRP and streptavidin-conjugated agarose beads, respectively. The invention allows detection and isolation of proteins with high yield, high specificity, and low contamination without harsh treatment of proteins. |
| FILED | Monday, November 17, 2003 |
| APPL NO | 10/715329 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070943 | Darzynkiewicz et al. |
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| ASSIGNEE(S) | Becton Dickinson and Company (Franklin Lakes, New Jersey) |
| INVENTOR(S) | Zbigniew Darzynkiewicz (Chappaque, New York); Frank Traganos (New York, New York); Gloria Juan (Sleepy Hollow, New York); Stefan Gruenwald (Encinitas, California) |
| ABSTRACT | Methods, reagents, and kits are provided that permit flow cytometric determination of the phosphorylation status of retinoblastoma susceptibility gene protein (pRB) in individual cells. Methods are described that permit the hypophosphorylated, active, form of pRB to be measured either as an absolute quantity or as a proportion of total cellular pRB. Further described are methods that permit pRB phosphorylation status to be correlated with cell cycle phase and with protein components of the cell cycle. Screening of chemical compounds for antiproliferative and antineoplastic activity using the flow cytometric assays is demonstrated. Reagent kits that facilitate the subject methods are also provided. |
| FILED | Wednesday, September 29, 2004 |
| APPL NO | 10/954097 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070944 | Black et al. |
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| ASSIGNEE(S) | CLF Medical Technology Acceleration Program, Inc. (Clifton, Park, New York) |
| INVENTOR(S) | Paul Black (Slingerlands, New York); Concetta DiRusso (Slingerlands, New York) |
| ABSTRACT | Methods for identifying modulators of fatty acid transport and/or uptake, comprising contacting, under conditions favorable for fatty acid uptake, a putative modulator, e.g., an inhibitor with a system comprising genetic material encoding a fatty acid transport mediator (“TTM”), particularly FAA1, FAA2, FAA3, FAA4, FAT1, fadL, fadD, FATP, CD36 and FABP, or orthologs, homologs, isoforms, variants, analogs, derivatives or fragments thereof, and combinations thereof, or fatty acid transport mediator proteins (“TTMps”), e.g., Faa1p, Faa2p, Faa3p, Faa4p, Fat1p, FadL, fatty acyl CoA synthetase, FATP, CD36 and FABP, or orthologs, homologs, isoforms, variants, analogs, derivatives or fragments thereof, and combinations thereof, and determining the effect of the putative modulator. The test system may be a cell such as Saccharomyces cerevisiae, E. coli, H. sapiens, etc. or an in vitro system. |
| FILED | Thursday, March 14, 2002 |
| APPL NO | 10/099350 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070954 | Korenberg et al. |
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| ASSIGNEE(S) | Julie R. Korenberg (Los Angeles, California); Xiao-Ning Chen (Los Angeles, California) |
| INVENTOR(S) | Julie R. Korenberg (Los Angeles, California); Xiao-Ning Chen (Arcadia, California) |
| ABSTRACT | The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human gene (SH3D1A), some polymorphic alleles of which cause susceptibility to cancers hematopoietic disorders and in particular platelet disorders, Down Syndrome, megakaryocytic disorders and leukemia. More specifically, the invention relates to isolated nucleic acid of the human SH3D1A gene, products, and their use in diagnosis and treatments. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the SH3D1A gene for mutations, which are useful for diagnosing the predisposition to hematopoietic disorders. |
| FILED | Friday, April 16, 1999 |
| APPL NO | 09/720934 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/69.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070957 | Olson et al. |
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| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Eric Olson (Dallas, Texas); Akiko Arai (Mie, Japan) |
| ABSTRACT | The present invention relates to a new polypeptide and the gene coding therefore, gene being an evolutionarily conserved actin-binding protein, called STARS (striated muscle activator of Rho signalin), that is expressed specifically in cardiac and skeletal muscle cells and is upregulated in response to calcineurin signaling during cardiac hypertrophy. STARS is localized to the thin filament of the sar comere and to actin stress fibers where it promotes actin bundling. STARS stimulates the transcriptional activity of serum response factor (SRF) through a mechanism that requires actin bundling and Rho kinase activation. STARS provides a mechanism for selectively enhancing the transcriptional activity of SRF in muscle cells and for linking changes in actin dynamics to gene transcription. Also disclosed are methods of using the gene and protein in drug screening and therapy, including, for example, use of the gene in gene therapy to treat cardiovascular disease. |
| FILED | Wednesday, August 20, 2003 |
| APPL NO | 10/644659 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/69.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070971 | Rosen et al. |
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| ASSIGNEE(S) | Syntex (U.S.A.), LLC (Palo Alto, California); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Steven Rosen (San Francisco, California); Jin Kyu Lee (Alameda, California); Stefan Hemmerich (Berkeley, California) |
| ABSTRACT | Novel glycosylsulfotransferases (GST-4α, GST-4β, and GST-6) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-4α, GST-4β, and GST-6. |
| FILED | Wednesday, October 29, 2003 |
| APPL NO | 10/697828 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/193 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070972 | O'Shea et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | John J. O'Shea (Silver Spring, Maryland); Warren J. Leonard (Bethesda, Maryland); James A. Johnston (Middletown, Maryland); Sarah M. Russell (Kensington, Maryland); Daniel W. McVicar (Charles Town, West Virginia); Masaru Kawamura (Rockville, Maryland) |
| ABSTRACT | An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing. |
| FILED | Friday, January 13, 1995 |
| APPL NO | 08/373934 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/194 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070973 | Lockridge et al. |
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| ASSIGNEE(S) | Board of Regents of the University of Nebraska (Omaha, Nebraska); Applied Molecular Evolution (San Diego, California) |
| INVENTOR(S) | Oksana Lockridge (Bellevue, Nebraska); Jeffry D. Watkins (Encinitas, California) |
| ABSTRACT | The invention provides four butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries comprising butyrylcholinesterase variants having at least one amino acid alteration in one or more regions of butyrylcholinesterase and further having at least one butyrylcholinesterase variant exhibiting enhanced cocaine hydrolysis activity compared to butyrylcholinesterase. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition. |
| FILED | Tuesday, December 26, 2000 |
| APPL NO | 09/748739 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/197 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071158 | Chinery et al. |
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| ASSIGNEE(S) | Atherogenics, Inc. (Norcross, Georgia) |
| INVENTOR(S) | Rebecca Chinery (Nashville, Tennessee); R. Daniel Beauchamp (Nashville, Tennessee); Robert J. Coffey (Woodside, California); Russell M. Medford (Atlanta, Georgia); Brian E. Wadzinski (Nashville, Tennessee) |
| ABSTRACT | A method to enhance the cytotoxic activity of an antineoplastic drug comprising administering an effective amount of the antineoplastic drug to a host exhibiting abnormal cell proliferation in combination with an effective cytotoxicity-increasing amount of an antioxidant. The invention also includes a method to decrease the toxicity to an antineoplastic agent or increase the therapeutic index of an antineoplastic agent administered for the treatment of a solid growth of abnormally proliferating cells, comprising administering an antioxidant prior to, with, or following the antineoplastic treatment. |
| FILED | Wednesday, February 07, 2001 |
| APPL NO | 09/779086 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/1 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071165 | Roeske |
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| ASSIGNEE(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| INVENTOR(S) | Roger W. Roeske (Indianapolis, Indiana) |
| ABSTRACT | Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety. |
| FILED | Friday, April 05, 2002 |
| APPL NO | 10/117364 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/15 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071168 | Stewart et al. |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of Colorado (, Colorado) |
| INVENTOR(S) | John M. Stewart (Denver, Colorado); Daniel C. F. Chan (Denver, Colorado); Lajos Gera (Denver, Colorado); Eunice York (Englewood, Colorado); Paul Bunn (Evergreen, Colorado) |
| ABSTRACT | The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula: [ACA]n-X[Formula I] wherein X is a linker group having 2–5 functional groups or is absent, n=1, and ACA is selected from the group consisting of Formula II, Formula III, Formula IV, Formula V, and Formula VI, as described herein. Other compounds described herein are defined by the Formula VII, as described herein. |
| FILED | Friday, December 28, 2001 |
| APPL NO | 10/035662 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/19 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071171 | Ariizumi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Regents the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Kiyoshi Ariizumi (Dallas, Texas); Akira Takashima (Irving, Texas) |
| ABSTRACT | Novel genes expressed selectively by long-term dendritic cell (DC) lines (XS series) from murine epidermis which retain important features of resident epidermal Langerhans cells (LC) are provided. These genes encode distinct type II membrane-integrated polypeptides, each consisting of a cytoplasmic domain, a transmembrane domain, an extracellular connecting domain, and a C-terminal extracellular domain that exhibits significant homology to the carbohydrate recognition domains (CRD)) of C-type lectins. Expression of both genes is highly restricted to cells of DC lineage (including epidermal LC). Thus, these genes encode new, DC-specific members of the C-type lectin family, now termed “DC-associated C-type lectin-1 and -2” (dectin-1 and dectin-2). Two isoforms of the dectin-1 molecule and five isoforms of the dectin-2 molecule have also been identified. The invention further provides His-tagged fusion proteins comprising 6x histidine and the extracellular domain of dectin-1 or dectin-2. Also provided are antibodies raised to synthetic peptides designed from the dectin-1 sequence or to the His-tagged fusion proteins described. |
| FILED | Tuesday, September 14, 1999 |
| APPL NO | 09/396492 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/44 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071172 | McCown et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Thomas J. McCown (Carrboro, North Carolina); Rebecca P. Haberman (Hillsborough, North Carolina) |
| ABSTRACT | The present invention provides delivery vectors for transferring a nucleic acid sequence to a cell in vitro, ex vivo or in vivo. The delivery vector comprises a segment encoding a secretory signal peptide. In embodiments of the invention, the delivery vector is an adeno-associated virus (AAV) vector. In other embodiments, the secretory signal peptide is a fibronectin secretory signal peptide (including variations and modifications, thereof). The delivery vectors of the invention may further comprise a heterologous nucleic acid sequence encoding a polypeptide of interest for transfer to a target cell, where the polypeptide of interest is operably associated with the secretory signal. Also disclosed are methods of transferring a nucleic acid of interest to a cell using the delivery vectors of the invention. |
| FILED | Tuesday, April 29, 2003 |
| APPL NO | 10/425328 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/44 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071179 | DeLuca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Hector F. DeLuca (Deerfield, Wisconsin); Rafal R. Sicinski (Warsaw, Poland) |
| ABSTRACT | A method of modifying or altering the structure of a 1α-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1α-hydroxyl in the axial orientation. This is accomplished by either locking the A-ring chair conformation in a geometry having an axially orientated 1α-hydroxyl, or by the addition of one or more substituents to the A-ring which interact with other substituents in the molecule or on the A-ring to provide a driving force to the A-ring to adopt a chair conformation which presents the 1α-hydroxyl in the axial orientation. |
| FILED | Friday, March 18, 2005 |
| APPL NO | 11/083570 |
| ART UNIT | 1616 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/167 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071200 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Neurocrine Biosciences, Inc. (San Diego, California) |
| INVENTOR(S) | Yun-Fei Zhu (San Diego, California); Collin Regan (San Diego, California); Jaimie K. Rueter (San Diego, California); Zhiqiang Guo (San Diego, California); Yongsheng Chen (San Diego, California); Charles Q. Huang (San Diego, California) |
| ABSTRACT | GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, R7 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof. |
| FILED | Tuesday, July 06, 2004 |
| APPL NO | 10/885511 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/274 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071227 | Huang et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Ru Chih C. Huang (Baltimore, Maryland); Ibrahim Shawky Abd Elazem (Baltimore, Maryland); Hong Shan Chen (Beijing, China PRC) |
| ABSTRACT | Purified antiviral compounds, pharmaceutical formulations containing the compounds, and methods of use of the compounds are provided. The compositions of the invention are isolated antiviral components from plant extracts derived from, for example, Salvia miltiorrhiza, that find use in the treatment of viral infections, such as by inhibiting the activity of viral integrase. Methods for isolation and purification of the antiviral compounds are additionally provided. |
| FILED | Tuesday, September 25, 2001 |
| APPL NO | 09/962923 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/469 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071293 | Tack et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The University of Iowa Research Foundation (Iowa City, Iowa); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Brian F. Tack (Iowa City, Iowa); Paul B. McCray, Jr. (Iowa City, Iowa); Michael Welsh (Riverside, Iowa); Sue M. Travis (Iowa City, Iowa); Robert Lehrer (Santa Monica, California) |
| ABSTRACT | The present invention relates to the use of antimicrobial peptides in the inhibition of microbial growth and proliferation. Novel antimicrobial truncated peptides are disclosed which are based upon SMAP 29 and RCAP 18, but which contain a lesser number of amino acid residues yet still retain bactericidal activity. In addition, synthetic peptides based upon the SMAP 29 protein are disclosed which have fewer amino acid residues and include substitutions yet retain substantial activity. The invention also relates to a method of inhibiting microbial growth by administering an effective amount of a peptide in accordance with the invention, or by combining the peptides with other antimicrobial agents or antibiotics. |
| FILED | Friday, August 18, 2000 |
| APPL NO | 09/642744 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071298 | Brown et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Truman R. Brown (Cornwall-On-Hudson, New York); Francis Kappler (Park, Pennsylvania) |
| ABSTRACT | Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a newly discovered metabolic pathway. According to the normal functioning on this pathway, fructose-lysine-3-phosphate (FL3P) is broken down to form free lysine, inorganic phosphate and 3-deoxyglucosone (3DG), the latter being a reactive protein modifying agent. 3DG can be detoxified by reduction to 3-deoxyfructose (3DF), or it can react with endogenous proteins to form advanced glycation end-product modified proteins (AGE-proteins). Also disclosed are therapeutic methods of using such inhibitors to treat glycogen storage diseases, including Fanconi's syndrome, as well as other pathological conditions resulting from the formation of AGE-proteins. |
| FILED | Wednesday, October 10, 2001 |
| APPL NO | 09/974323 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/322 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071302 | Horvitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | H. Robert Horvitz (Cambridge, Massachusetts); Junying Yuan (Newton, Massachusetts); Shai Shaham (Boston, Massachusetts) |
| ABSTRACT | Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally related cell death genes from various organisms; methods and agents for altering (increasing or decreasing) the activity of the cell death-genes and, thus, of altering cell death; and uses therefor. Specifically, two genes shown to be essential for almost all of the cell deaths which occur in the development of C. elegans, referred to as ced-3 and ced-4, have been cloned, sequenced and characterized. |
| FILED | Wednesday, May 24, 2000 |
| APPL NO | 09/577897 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/350 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071315 | Kreek et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Mary Jeanne Kreek (New York, New York); Karl Steven LaForge (New York, New York) |
| ABSTRACT | Provided herein are variant alleles of a gene encoding a mu opioid receptor, along with cloning vectors for replicating such variant alleles, expressing vectors for expressing the variant alleles to produce variant mu opioid receptors, and antibodies to such variant receptors. Also disclosed are binding characteristics of such variant receptors regarding binding to opioid ligands, and the using of such binding characteristics to diagnose a subjects susceptibility to pain, susceptibility to an addictive disease, selecting an appropriate pain reliever along with a therapeutically effective amount of the reliever to administer to a subject suffering from pain. In addition, diagnostic methods for diagnosing a disease or disorder such as infertility, constipation, diarrhea, decreased immune response relative to a standard, and decreased ability to withstand stress relative to a standard, along with commercial kits for diagnosing such diseases or disorders. Furthermore, the invention is also directed to identification of targeted prevention methods, early therapeutic intervention, and improved treatment of opioid addiction, infertility, constipation, diarrhea, impaired immune responsiveness, and stress. |
| FILED | Monday, June 18, 2001 |
| APPL NO | 09/883839 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/23.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071318 | Olson et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Eric N. Olson (Dallas, Texas); Jeffrey A. Spencer (Grand Prairie, Texas) |
| ABSTRACT | The present invention discloses new muscle ring finger (MURF) proteins designate MURF-1, MURF-2 and MURF-3. The genes encoding these MURFs also are provided. MURFs interact with microtubules and thus play a role in cytoskeletal function, mitosis and cell growth. Thus, the uses of MURFs in diagnosis, treatment and drug screening, in particular relation to cardiomyopathies, are described. |
| FILED | Tuesday, February 10, 2004 |
| APPL NO | 10/775649 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Organic compounds 536/23.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071323 | Kalin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Ned H. Kalin (Madison, Wisconsin); Patrick H. Roseboom (Madison, Wisconsin); Charles F. Landry (Madison, Wisconsin); Steven A. Nanda (Madison, Wisconsin) |
| ABSTRACT | The DNA sequences of human and rat CRF2α receptor promoters are disclosed. Certain functional fragments of the human CRF2α receptor promoter are also disclosed. Further disclosed are a method of identifying functional fragments of human and rat CRF2α receptor promoters and a method of identifying agents that can alter the activity of the human or rat CRF2α receptor promoter. |
| FILED | Tuesday, November 12, 2002 |
| APPL NO | 10/293702 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/24.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071474 | Wong et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Wai-Hoi Wong (Houston, Texas); Hongdi Li (Pearland, Texas); Jorge Uribe (Houston, Texas); Yaqiang Liu (Houston, Texas); Hossain Baghaei (Sugarland, Texas) |
| ABSTRACT | Methods and apparatus for tuning scintillation detectors. An output of a first light is equalized with an output of a neighboring, second light. The outputs are measured by one or more light detectors shared by the first and second lights. Outputs of a plurality of light detectors are equalized using the equalized output of the first light. |
| FILED | Monday, December 22, 2003 |
| APPL NO | 10/743565 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Radiant energy 250/363.90 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071689 | Golay et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Xavier Golay (Singapore, Singapore); Hanzhang Lu (Baltimore, New York); Peter C. M. van Zijl (Ellicott City, Maryland) |
| ABSTRACT | Featured are methods for magnetic resonance imaging in which MR signals of selected tissues, fluid or body components in a target area are desired to be essentially eliminated, which method includes applying an initial RF inversion pulse to invert the magnetization of the selected tissues or to apply any other T1 preparation aimed at nulling one or more tissue species and successively applying one or more RF inversions pulses thereafter. More particularly, the successively applied RF inversion pulses are applied so as to essentially maintain the magnetization of the selected tissues at or about the zero-crossing point of the longitudinal magnetization. Such methods further include interleaving a plurality of excitation pulses for acquiring image data and the RF inversion pulses so that at least one of the plurality of excitation pulses follows in a time sequence the application of one of the applied RF inversion pulses such that the image data is acquired following an inversion pulse. |
| FILED | Thursday, December 04, 2003 |
| APPL NO | 10/729360 |
| ART UNIT | 2859 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/309 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071690 | Butts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Kim Butts (Redwood City, California); John M. Pauly (Redwood City, California) |
| ABSTRACT | Magnetic resonance imaging utilizes view angle tilting to correct for in-plane distortions with each RF excitation pulse being followed by a plurality of signal readouts to reduce image blurring. Each image readout is in the presence of a frequency select gradient (GX) and a slice select gradient (GZ), and at least the slice select gradient is refocused after each readout of an image signal. Each readout can have a time duration of the main lobe of the RF excitation pulse or the readout can have a higher bandwidth with an increased number of readouts. The combining of multiple readouts diminishes slice profile modulation resulting from Fourier transform. |
| FILED | Tuesday, November 23, 2004 |
| APPL NO | 10/996965 |
| ART UNIT | 2859 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/309 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072045 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zhongping Chen (Irvine, California); Zhihua Ding (Zhejiang, China PRC); J. Stuart Nelson (Laguna Niguel, California) |
| ABSTRACT | In optical coherence tomography (OCT), Axial and lateral resolutions are determined by the source coherence length and numerical aperture of the sampling lens, respectively. While axial resolution can be improved using a broadband light source, there is a trade-off between lateral resolution and focusing depth when conventional optical elements are used. The incorporation of an axicon lens into the sample arm of the interferometer overcomes this limitation. Using an axicon lens with a top angle of 160 degrees, 10 μm or better-lateral resolution is maintained over a focusing depth of at least 6 mm. In addition to high lateral resolution, the focusing spot intensity is approximately constant over a greater depth range. |
| FILED | Thursday, January 16, 2003 |
| APPL NO | 10/345671 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/479 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072701 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | CAS Medical Systems, Inc. (Branford, Connecticut) |
| INVENTOR(S) | Bo Chen (Derby, Connecticut); Paul B. Benni (Stamford, Connecticut) |
| ABSTRACT | A method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided that utilizes a near infrared spectrophotometric (NIRS) sensor capable of transmitting a light signal into the tissue of a subject and sensing the light signal once it has passed through the tissue via transmittance or reflectance. The method includes the steps of: (1) transmitting a light signal into the subject's tissue, wherein the transmitted light signal includes a first wavelength, a second wavelength, and a third wavelength; (2) sensing a first intensity and a second intensity of the light signal, along the first, second, and third wavelengths after the light signal travels through the subject at a first and second predetermined distance; (3) determining an attenuation of the light signal for each of the first, second, and third wavelengths using the sensed first intensity and sensed second intensity of the first, second, and third wavelengths; (4) determining a difference in attenuation of the light signal between the first wavelength and the second wavelength, and between the first wavelength and the third wavelength; and (5) determining the blood oxygen saturation level within the subject's tissue using the difference in attenuation between the first wavelength and the second wavelength, and the difference in attenuation between the first wavelength and the third wavelength. |
| FILED | Thursday, July 24, 2003 |
| APPL NO | 10/628068 |
| ART UNIT | 3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Surgery 6/331 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072706 | Baumgardner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | James Baumgardner (Milmont Park, Pennsylvania); David Lipson (Wynnewood, Pennsylvania); Rahim Rizi (Montgomeryville, Pennsylvania); David Roberts (Rosemont, Pennsylvania); Mitchell Schnall (Broomall, Pennsylvania) |
| ABSTRACT | The present invention offers novel equilibration methods for very high resolution, three-dimensional imaging of imaging of lung compliance and distribution of functional residual capacity (FRC) in the lung using hyperpolarized helium-3 (3He) gas (H3He), and collecting local magnetic resonance image data therefrom. Using the present methods permits many functions that have been performed on a regional level for the whole lung using non-polarized helium, to be calculated for the first time from the local MRI measurements of local H3He, such as measuring volume or compliance. |
| FILED | Friday, February 08, 2002 |
| APPL NO | 10/071435 |
| ART UNIT | 3737 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Surgery 6/420 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072707 | Galloway, Jr. et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Robert L. Galloway, Jr. (Nashville, Tennessee); William C. Chapman (Nashville, Tennessee); James D. Stefansic (Nashville, Tennessee); Alan J. Herline (Nashville, Tennessee); Michael I. Miga (Franklin, Tennessee); David M. Cash (Nashville, Tennessee); Tuhin K. Sinha (Nashville, Tennessee) |
| ABSTRACT | A method and apparatus for collecting and processing physical space data used while performing image-guided surgery is disclosed. Physical space data is collected by probing physical surface points of surgically exposed tissue. The physical space data provides three-dimensional (3-D) coordinates for each of the physical surface points. Based on the physical space data collected, point-based registrations used to indicate surgical position in both image space and physical space are determined. In one embodiment, the surface of surgically exposed tissue of a living patient is illuminated with laser light. Light reflected from the illuminated surface of the exposed tissue is received and analyzed. In another embodiment, one or more magnetic fields of known shape and size are established in the proximity of the exposed tissue. Data associated with the strength of the magnetic fields is acquired and analyzed. |
| FILED | Wednesday, April 16, 2003 |
| APPL NO | 10/418187 |
| ART UNIT | 3737 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Surgery 6/424 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072794 | Wittkowski |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Rockefeller University (New York, New York) |
| INVENTOR(S) | Knut M. Wittkowski (New York, New York) |
| ABSTRACT | A method of analysis including an intrinsically valid class of statistical methods for dealing with multivariate ordinal data. A decision support system that can (1) provide automated decision support in a transparent fashion (2) optionally be controlled by a decision maker, (3) provide for an evidence acquisition concept, including automatically increasing the content of an underlying database, and (4) provide a computationally efficient interactive distributed environment. The method is exemplified in the context of assisted diagnostic support. |
| FILED | Wednesday, August 28, 2002 |
| APPL NO | 10/230019 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/179 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 07069642 | Bower et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | QorTek, Inc. (Williamsport, Pennsylvania) |
| INVENTOR(S) | Bruce Bower (Williamsport, Pennsylvania); Gareth Knowles (Williamsport, Pennsylvania) |
| ABSTRACT | A method of fabricating a current control device is presented. The method impregnates a pressure conduction composite within a current control device with a fluid additive via suffusion. The suffusion process is performed by placing the pressure conduction composite within a bath of a liquid additive. The method generally includes the steps of mixing a compressible non-conductive matrix and conductive filler, forming a pressure conduction composite composed of the non-conductive matrix having the conductive filler electrically isolated therein, suffusing the composite within a bath so as to impregnate the composite with an additive, and attaching a pair of conductive plates to the composite. Alternate methods include attaching non-conductive plates to the composite, forming pores within the pressure conduction composite, and inserting a temperature responsive material into a porous composite. |
| FILED | Wednesday, January 26, 2005 |
| APPL NO | 11/044856 |
| ART UNIT | 3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Metal working 029/619 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07069717 | Grainger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | SpaceDev, Inc. (Poway, California) |
| INVENTOR(S) | Chris Grainger (Poway, California); Frank Macklin (Poway, California) |
| ABSTRACT | Disclosed is a propulsion system for a spacecraft. The propulsion system includes a supply of oxidizer and at least one nozzle. A conduit fluidly couples the supply of oxidizer and the nozzle. The conduit provides a pathway for oxidizer to flow in a downstream direction from the supply of oxidizer toward and into the nozzle. A pressure regulator is coupled to the conduit and is interposed between the supply of oxidizer and the nozzle, wherein the pressure regulator regulates the pressure of oxidizer flowing through the conduit and downstream of the pressure regulator to a pressure at or below the pressure required to maintain the oxidizer in a gas state to ensure that the any oxidizer flowing through the conduit is in a gas state prior to entering the nozzle. The conduit supplies oxidizer from the supply of oxidizer to a hybrid rocket motor. |
| FILED | Thursday, April 15, 2004 |
| APPL NO | 10/825924 |
| ART UNIT | 3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Power plants 060/220 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07069814 | Chervak et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Steven G. Chervak (Bel Air, Maryland); Arthur F. Yeager (Kailua, Hawaii) |
| ABSTRACT | The present invention is a portable securing apparatus for fastening and unfastening a lid to a container. The apparatus minimizes or prevents health risks of medical conditions associated with repetitive and cumulative motions by minimizing or preventing repetitive motions performed by an individual. The apparatus includes a base and a balancer configured to hold a rotational drive mechanism. The base provides support for the container by allowing the container to rest thereon in an upright position. The balancer is connected to the base and is configured to hold the rotational drive mechanism. The balancer provides for movement of the rotational drive mechanism to engage the container lid. |
| FILED | Thursday, December 16, 2004 |
| APPL NO | 11/012733 |
| ART UNIT | 3723 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Tools 081/3.390 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07069830 | Meyer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Charles E. Meyer (Edwards, California) |
| ABSTRACT | Provided is a method for repairing an aperture in a panel in which, a) a plug is inserted in a such aperture to fill same and project above the surface of the panel, b) the plug is adhered in the aperture and c) the plug is flush cut with such surface to repair the panel. Also provided is a tool for flush cutting such projection wherein a blade is mounted across a frame, which blade is mounted at about 90 degrees to the plane of such frame so as to be parallel with the surface of the panel when the frame is mounted upright thereon, to provide clearance for the hand that guides the frame while flush cutting the projection from the panel. Desirably the ends of the saw blade are recessed between smooth feet of the frame so that the blade is elevated slightly above the panel surface, to reduce or avoid scratching thereof during the flush cutting step. |
| FILED | Monday, June 19, 2000 |
| APPL NO | 09/596432 |
| ART UNIT | 3724 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Cutting 083/13 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07069861 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Charles H. Robinson (Silver Spring, Maryland); Robert H. Wood (Laurel, Maryland); Mark R. Gelak (Columbia, Maryland); David Hollingsworth (Fallon, Nevada) |
| ABSTRACT | A microscale firetrain for a safe and arm device having a safe position and an armed position, the firetrain including an input explosive column having a longitudinal axis; a transfer charge having a longitudinal axis and first and second ends and movable from a safe position to an armed position; a receptor charge having a longitudinal axis that is non-collinear with and substantially parallel to the longitudinal axis of the input explosive column; wherein, in the safe position, the transfer charge is remote from both the input explosive column and the receptor charge; and wherein, in the armed position, the input explosive column is adjacent the first end of the transfer charge to thereby initiate the transfer charge, the longitudinal axis of the input explosive column is substantially perpendicular to the longitudinal axis of the transfer charge, the second end of the transfer charge is adjacent the receptor charge to thereby initiate the receptor charge and the longitudinal axis of the receptor charge is substantially perpendicular to the longitudinal axis of the transfer charge. |
| FILED | Thursday, April 01, 2004 |
| APPL NO | 10/708930 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ammunition and explosives 12/222 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070144 | DiCocco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Orbital Research Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Jack DiCocco (Granger Township, Ohio); Troy Prince (Cleveland, Ohio); Mehul Patel (Streetsboro, Ohio); Tsun Ming Terry Ng (Sylvania, Ohio) |
| ABSTRACT | The present invention relates to an afterbody flow control system and more particularly to aircraft or missile flow control system for enhanced maneuverability and stabilization. The present invention further relates to a method of operating the flow control system. In one embodiment, the present invention includes a missile or aircraft comprising an afterbody and a forebody; at least one activatable flow effector on the missile or aircraft afterbody; at least one sensor each having a signal, the at least one sensor being positioned to detect forces or flow conditions on the missile or aircraft afterbody; and a closed loop control system; wherein the closed loop control system is used for activating and deactivating the at least one activatable flow effector based on at least in part the signal of the at least one sensor. |
| FILED | Tuesday, December 30, 2003 |
| APPL NO | 10/750422 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeronautics and astronautics 244/3.210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070364 | Weare |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Lockheed Martin Corporation (Bethesda, Maryland) |
| INVENTOR(S) | Mark A. Weare (Weatherford, Texas) |
| ABSTRACT | A reverse chamfering and countersink stop tool allows the required diameter of a countersink in a workpiece to be maintained in areas that have limited accessibility for the user assembling a fastener to the workpiece. The tool controls the dimension required for proper installation of fasteners under such conditions. The tool can also be used for other applications that require control of the diameter of a chamfer, and allows the diameter of the chamfer/countersink to be set outside the point of use for maintaining proper tolerances. The tool utilizes a modified reverse countersink cutter that is captured inside an externally threaded adjustable stop housing. The captured cutter is movable both axially and rotationally, and is driven by a drill equipped with a pilot. The stop position of the cutter is controlled by a series of nuts that are located and threaded on the exterior of the housing. |
| FILED | Monday, March 10, 2003 |
| APPL NO | 10/385020 |
| ART UNIT | 3722 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Cutting by use of rotating axially moving tool 48/1.R00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070565 | Vaezy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Shahram Vaezy (Seattle, Washington); Adrian Prokop (Lynnwood, Washington); Roy W. Martin (Anacortes, Washington); Peter Kaczkowski (Seattle, Washington); Misty Noble (Seattle, Washington) |
| ABSTRACT | The present invention employs hydrogels as acoustic couplings for clinical applications of ultrasound imaging and therapy, but is particularly applicable to high intensity focused ultrasound (HIFU) based therapy. While other materials can be used, it has been determined that polyacrylamide is sufficiently robust and transmissive to withstand the high temperatures encountered in HIFU therapy. One embodiment of a hydrogel coupling is configured in shape and size (length) to ensure that a focal region of an ultrasound transducer is disposed proximate the target area when the distal tip of the transducer is in contact with tissue. These couplings can be shaped to correspond to the beam focus characteristics of specific transducers. Water can be applied to hydrate the tip of the hydrogel coupling during use, and medication absorbed into the hydrogel material can be applied to the tissue in contact with the distal surface of the hydrogel. |
| FILED | Friday, May 30, 2003 |
| APPL NO | 10/449819 |
| ART UNIT | 3737 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Surgery 6/459 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070681 | Santiago et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Juan G. Santiago (Fremont, California); Michael H. Oddy (San Francisco, California); James C. Mikkelsen, Jr. (Los Altos, California) |
| ABSTRACT | A novel electrokinetic instability (EKI) micromixer and method takes advantage of the EKI to effect active rapid stirring of confluent microstreams of biomolecules without moving parts or complex microfabrication processes. The EKI is induced using an alternating current (A/C) electric field. Within seconds, the randomly fluctuating, three-dimensional velocity field created by the EKI rapidly and effectively stirs an initially heterogeneous solution and generates a homogeneous solution that is useful in a variety of biochemical and bioanalytical systems. Microfabricated on a glass substrate, the inventive EKI micromixer can be easily and advantageously integrated in molecular diagnostics apparatuses and systems, such as a chip-based “Lab-on-a-Chip” microfluidic device. |
| FILED | Thursday, January 24, 2002 |
| APPL NO | 10/056944 |
| ART UNIT | 1753 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Chemistry: Electrical and wave energy 24/451 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070734 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Ex One Company (Irwin, Pennsylvania) |
| INVENTOR(S) | Jianxin Liu (N. Huntingdon, Pennsylvania); Michael L. Ryneson (Pittsburgh, Pennsylvania) |
| ABSTRACT | A green article comprising an A-B powder mixture and methods of manufacturing such green articles and corresponding sintered articles are disclosed. The A-B powder mixture consists of a minor volume fraction of a relatively fine powder A and a complementary major volume fraction of a relatively coarse prealloyed powder B wherein the A-B powder mean particle size ratio is at least about 1:5. Metal powder A consists of one or more elemental metals or alloys which has a melting or solidus temperature above the highest sintering temperature at which the A-B powder mixture may be sintered without slumping. Prealloyed metal powder B consists of one or more alloys which are amenable to supersolidus liquid phase sintering. Green articles made from the A-B powder have a wider sintering temperature window than do articles made from prealloyed metal powder B alone. |
| FILED | Tuesday, March 16, 2004 |
| APPL NO | 10/801970 |
| ART UNIT | 1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Powder metallurgy processes 419/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070773 | Conerly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Tiax LLC (Cambridge, Massachusetts) |
| INVENTOR(S) | Lisa L. Conerly (Quincy, Massachusetts); Daniel J. Ehntholt (Hudson, Massachusetts); Alan S. Louie (Sudbury, Massachusetts); Richard H. Whelan (Norfolk, Massachusetts) |
| ABSTRACT | The present invention provides compositions effective in decontaminating either biological pathogens or both chemical and biological pathogens. These compositions are particularly suitable for the decontamination of biological warfare agents or both chemical and biological warfare agents The compositions comprise generally a blend of biocides, and may additionally comprise a protein and an enzyme. Further, the composition is contained in a buffered foam forming material for ease in distribution The compositions are nontoxic, noncorrosive and nonflammable. |
| FILED | Thursday, February 01, 2001 |
| APPL NO | 10/182821 |
| ART UNIT | 1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/94.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070882 | Ferrando |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | William A. Ferrando (Arlington, Virginia) |
| ABSTRACT | An anode for use in a primary metal-air battery having an alkaline or neutral salt electrolyte, the anode comprising: a low molecular weight reactive metal substrate; a low molecular weight reactive metal powder; and at least a two-component electrolyte resistant polymer system; the first component is an ionic conductive linearized hydrogel, the second component is an inert structural polymer matrix, the reactive metal powder is dispersed and the first component is uniformly dispersed within the second component to form a material, and the reactive metal is selected from the group consisting of magnesium, aluminum, tin, mixtures of aluminum, tin and magnesium and alloys thereof. |
| FILED | Tuesday, November 19, 2002 |
| APPL NO | 10/298516 |
| ART UNIT | 1745 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Chemistry: Electrical current producing apparatus, product, and process 429/218.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070886 | Cetin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Aprilis, Inc. (Maynard, Massachusetts) |
| INVENTOR(S) | Erdem A. Cetin (Waltham, Massachusetts); Richard A. Minns (Arlington, Massachusetts); David A. Waldman (Concord, Massachusetts) |
| ABSTRACT | Disclosed is a holographic recording medium. The novel holographic recording mediums disclosed herein comprises: a) at least one polyfunctional epoxide monomer or oligomer which undergoes acid initiated cationic polymerization. Each epoxide in the monomer or oligomer is linked by group comprising a siloxane to a silicon atom and each monomer or oligomer has an epoxy equivalent weight of greater than about 300 grams/mole epoxide; b) a binder which is capable of supporting cationic polymerization; c) an acid generator capable of producing an acid upon exposure to actinic radiation; and optionally d) a sensitizer. |
| FILED | Tuesday, July 13, 2004 |
| APPL NO | 10/890425 |
| ART UNIT | 1712 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Radiation imagery chemistry: Process, composition, or product thereof 430/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070928 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Lexington, Massachusetts); Zev Gartner (Somerville, Massachusetts); Matthew W. Kanan (Cambridge, Massachusetts) |
| ABSTRACT | Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule or related molecules for re-screening. The inventive methods and compositions of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein. |
| FILED | Tuesday, March 19, 2002 |
| APPL NO | 10/101030 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071268 | Lindsay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Geoffrey Andrew Lindsay (Ridgecrest, California); Peter Zarras (Ridgecrest, California); John D. Stenger-Smith (Ridgecrest, California) |
| ABSTRACT | An electro-optic (EO) polymer that has a tunable index of refraction and are synthesized by the copolymerization a bisphenol monomer including a chromophoric structure and two diepoxy monomers. One diepoxy monomer includes at least one fluorine atom, and the second diepoxy monomer includes no fluorine atoms. The EO films are prepared by applying an electric field across the film as the film is heated to its glass transition temperature. The electric field is removed after cooling the film. The index of refraction of these nonlinear optical polymer materials is tuned between about 1.58 to about 1.66 (measured with light having a wavelength of about 1.3 microns). |
| FILED | Wednesday, July 02, 2003 |
| APPL NO | 10/615460 |
| ART UNIT | 1712 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Synthetic resins or natural rubbers 525/527 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071431 | Ruan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Meichun Ruan (Tempe, Arizona); Jun Shen (Phoenix, Arizona); Charles Wheeler (Paradise Valley, Arizona) |
| ABSTRACT | A switch with an open state and a closed state suitably includes a cantilever having first and second states corresponding to the open and closed states of the switch, respectively. The switch may also include a magnet configured to provide an electromagnetic field that maintains said cantilever in one of the first and second states. Various embodiments may also include an electrode or electrical conductor configured to provide an electric potential or electromagnetic pulse, as appropriate, to switch the cantilever between the first and second states. Various embodiments may be formulated with micromachining technologies, and may be formed on a substrate. |
| FILED | Tuesday, March 06, 2001 |
| APPL NO | 09/799746 |
| ART UNIT | 2833 — Electrical Circuits and Systems |
| CURRENT CPC | Electricity: Circuit makers and breakers 2/181 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071465 | Hill, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Washington State University Research Foundation (Pullman, Washington) |
| INVENTOR(S) | Herbert Henderson Hill, Jr. (Pullman, Washington); Maggie Tam (Pullman, Washington) |
| ABSTRACT | The invention includes an ion mobility spectrometer having a liquid filled drift chamber. The chamber has an ionization region partitioned from and an ion separation region by a reversible ion-migration block. An electrical field within the chamber allows ions to migrate toward the electrode collector. Passage of ions from the ionization region is triggered by reversing the block allowing ions to migrate into the ion separation region. The invention includes a method of ion mobility analysis in liquid phase. Ions are mobilized to migrate through a drift liquid and are detected at an end of a drift chamber. The invention also includes a method of generating ions in a sample. A sample containing molecules in a first solvent is introduced into a second solvent through a charged capillary where the electrically charged sample is electro-disperses to ionize the molecules. |
| FILED | Thursday, October 14, 2004 |
| APPL NO | 10/966325 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Radiant energy 250/286 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071657 | Tupper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Raven Technology, LLC (Brunswick, Maine) |
| INVENTOR(S) | Christopher N. Tupper (Harpswell, Maine); Duncan G. Wood (Harpswell, Maine) |
| ABSTRACT | A single-pole type generator with low loss magnetic core is excited by a field coil that is part of a low loss series resonant circuit tuned to a desired AC power frequency, which may be frequencies such as 50 Hz or 60 Hz or 400 Hz. The series resonant circuit is excited at the resonant frequency. The resulting resonant behavior of the excitation circuit automatically provides the high driving voltages and sinusoidal energy storage patterns needed to efficiently modulate the magnetic field at the desired power frequency. This modulation of the excitation field is amplified by mechanical power from a rotating shaft and modulates the output current and voltage of a single phase output circuit of the single-pole type generator at that power frequency in a sinusoidal pattern thus delivering alternating current power without any requirement for further electronic rectification, commutation or processing. Design considerations critical to the implementation of a practical single-pole type generator suitable for this application are disclosed. |
| FILED | Thursday, March 04, 2004 |
| APPL NO | 10/793493 |
| ART UNIT | 2834 — Electrical Circuits and Systems |
| CURRENT CPC | Electricity: Single generator systems 322/29 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071791 | Wilson, III |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Robert E. Wilson, III (Forked River, New Jersey) |
| ABSTRACT | An automatic antenna-switching apparatus is provided for the user to connect a single multiband communications platform to a group of antennas with different frequencies by detecting the RF energy input representing the user's selected frequency and automatically switching to the properly polarized and matched antenna for the intended radio band in the group of antennas. The automatic antenna-switching apparatus includes an RF input port, a means for RF sensing, a means for antenna port selection, a group of RF output connectors and a group of different output antennas. The RF sensing means senses the RF energy with a means for frequency counting that determines the exact frequency represented by the RF energy during a particular radio transmission. The RF sensing means sends a frequency count output to the antenna port selection means that compares the frequency count output with the available connected output antennas. The present invention also contemplates an automatic antenna-switching system and a method for automatically switching antennas for a multiband communications device to different frequencies. |
| FILED | Thursday, January 30, 2003 |
| APPL NO | 10/361035 |
| ART UNIT | 2817 — Semiconductors/Memory |
| CURRENT CPC | Wave transmission lines and networks 333/17.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071862 | Scarpulla |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | John R. Scarpulla (Rancho Palos Verdes, California) |
| ABSTRACT | A transmission line analog-to-digital converter uses an unterminated transmission line driven by a current source to generate a stair-step waveform having equal time step periods for measuring the conversion time as a digital output value of an analog input. The converter has the advantages of simplicity, accuracy, high speed, low transistor count, and low power consumption. Fast successive approximation converters can be used for improved speed and accuracy of digital conversion of analog signals. |
| FILED | Friday, June 10, 2005 |
| APPL NO | 11/151183 |
| ART UNIT | 2819 — Semiconductors/Memory |
| CURRENT CPC | Coded data generation or conversion 341/155 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071873 | Tomasic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Boris Tomasic (Harvard, Massachusetts); Sarjit S. Bharj (Mercerville, New Jersey); Paul J. Oleski (Holland Patent, New York); John P. Turtle (Wellesley, Massachusetts) |
| ABSTRACT | Transmit/Receive (T/R) module that provides multiple simultaneous ground to satellite links with rapid pointing and acquisition. The (T/R) module incorporates independent gain and phase control. Left-hand or right-hand circular polarization can be supplied to dual feed antennas. Present invention allows each antenna to be independently polarized. Low-cost componentry is utilized throughout. On-board control of the (T/R) module is obtained using a complex programmable logic device (CPLD) and a micro controller. CPLD provided separate control of four phase shifters, attenuators, channel polarization as well as transmitter on/off control. Telemetry is provided through built-in test (BIT) routine. |
| FILED | Friday, April 29, 2005 |
| APPL NO | 11/124511 |
| ART UNIT | 3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Communications: Directive radio wave systems and devices 342/372 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072045 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zhongping Chen (Irvine, California); Zhihua Ding (Zhejiang, China PRC); J. Stuart Nelson (Laguna Niguel, California) |
| ABSTRACT | In optical coherence tomography (OCT), Axial and lateral resolutions are determined by the source coherence length and numerical aperture of the sampling lens, respectively. While axial resolution can be improved using a broadband light source, there is a trade-off between lateral resolution and focusing depth when conventional optical elements are used. The incorporation of an axicon lens into the sample arm of the interferometer overcomes this limitation. Using an axicon lens with a top angle of 160 degrees, 10 μm or better-lateral resolution is maintained over a focusing depth of at least 6 mm. In addition to high lateral resolution, the focusing spot intensity is approximately constant over a greater depth range. |
| FILED | Thursday, January 16, 2003 |
| APPL NO | 10/345671 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/479 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072414 | Lui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Gee L. Lui (Westminster, California); Kuang Tsai (Santa Ana, California) |
| ABSTRACT | A premodulation precoding method precodes a data sequence in a Gaussian minimum shift keying (GMSK) modulator to improve the bit error rate performance of a coherent Viterbi receivers generating estimates of the communicated data sequence without the use of differential decoding while preserving the spectrum of 2-ary and 4-ary GMSK signals over a wide range of bandwidth time products. |
| FILED | Tuesday, September 07, 1999 |
| APPL NO | 09/390966 |
| ART UNIT | 2631 — Digital Communications |
| CURRENT CPC | Pulse or digital communications 375/274 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072500 | Cerrina et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Francesco Cerrina (Madison, Wisconsin); Mo-Huang Li (Madison, Wisconsin); Chang-Han Kim (Madison, Wisconsin) |
| ABSTRACT | An image locking system for DNA micro-array synthesis provides a feedback system to stabilize or lock the image with respect to an image capture device, such as a camera and/or microscope. The image locking system includes the use of detection or reference marks. When a shift in image position is detected, a correction signal is sent to one of two mirrors, moving the image to correct for the shift in image position. The system comprises a first light beam directed towards a micromirror device that forms an alignment pattern on a reaction cell and a second light beam directed towards the micromirror device that forms a micro-array image on an active surface of the reaction cell. A camera captures the alignment pattern and an alignment mark. A computer calculates a correction signal to realign the alignment pattern with the alignment mark when movement is detected. |
| FILED | Friday, May 07, 2004 |
| APPL NO | 10/841847 |
| ART UNIT | 2624 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/128 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072531 | Djordjev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Agilent Technologies, Inc. (Palo Alto, California) |
| INVENTOR(S) | Kostadin D. Djordjev (Cupertino, California); Michael R. T. Tan (Menlo Park, California); Chao-Kun Lin (Fremont, California); Scott W. Corzine (Sunnyvale, California) |
| ABSTRACT | A light modulator having a waveguide and a resonator is disclosed. The waveguide routes light of wavelength λ past the resonator. The resonator is coupled to the waveguide such that a portion of the light is input to the resonator, the resonator having a resonance at λ. The resonator includes a gain region in which light of wavelength λ is amplified and an absorption region in which light of wavelength λ is absorbed, the absorption region having first and second states, the first state absorbing less light of wavelength λ than the second state, the state of the absorption region is determined by an electrical signal coupled to the absorption region. The gain region provides a gain that compensates for the light absorption in the first state. In one embodiment, the waveguide and resonator are critically coupled when the absorption region is in the second state. |
| FILED | Thursday, September 16, 2004 |
| APPL NO | 10/944372 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical waveguides 385/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072539 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ming-Chiang Wu (Orinda, California); Jui-Che Tsai (Berkeley, California) |
| ABSTRACT | A 1×N2 wavelength selective switch (WSS) configuration in which switch elements are configured in a way that enables the input or output fibers to be arranged in a two-dimensional (2D) array. By employing 2D arrays of input/output channels, the channel count is increased from N to N2 for wavelength selective switches. In one embodiment, in which the components are arranged as a 2-f imaging system, a one-dimensional (1D) array of mirrors is configured such that each mirror has a dual scanning axis (i.e., each mirror can be scanned in X and Y directions). In another embodiment, in which the components are arranged as a 4-f imaging system, two 1D arrays of mirrors are configured with orthogonal scanning directions. In both embodiments, the number of ports is increased from N to N2. |
| FILED | Monday, February 07, 2005 |
| APPL NO | 11/053182 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical waveguides 385/18 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072555 | Figotin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Aleksandr Figotin (Irvine, California); Ilya Vitebskiy (Irvine, California) |
| ABSTRACT | Systems and methods are provided that allow transmission of an electromagnetic wave in and through a periodic multilayered photonic device. The photonic device preferably is a periodic stack of plane-parallel layers with at least one them displaying dielectric anisotropy with a principle anisotropic axis forming an oblique angle with the normal to the layers. The wave obliquely incident on the surface of the device can be almost completely converted into an axially frozen mode characterized by a significantly increased amplitude, decreased group velocity normal to the incident surface and increased energy flux substantially tangential to the incident surface. The photonic device can be used in numerous applications over a wide range of frequencies up to and including the ultraviolet spectrum. The photonic device can be further configured with a deflection device which substantially increases the operational frequency range of the photonic device. |
| FILED | Monday, May 03, 2004 |
| APPL NO | 10/839117 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical waveguides 385/129 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072560 | Bramson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Michael D. Bramson (Ridgecrest, California) |
| ABSTRACT | An apparatus and method for stowage of flexible linear objects including optical fibers, hoses, ropes, and electrical wires/cables. The apparatus includes spreader structures dimensioned and configured to stow objects in a |
| FILED | Thursday, March 10, 2005 |
| APPL NO | 11/078941 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical waveguides 385/135 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072883 | Potok et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | UT-Battelle LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Thomas E. Potok (Oak Ridge, Tennessee); Mark Thomas Elmore (Oak Ridge, Tennessee); Joel Wesley Reed (Knoxville, Tennessee); Jim N. Treadwell (Louisville, Tennessee); Nagiza Faridovna Samatova (Oak Ridge, Tennessee) |
| ABSTRACT | A computer method of gathering and summarizing large amounts of information comprises collecting information from a plurality of information sources (14, 51) according to respective maps (52) of the information sources (14), converting the collected information from a storage format to XML-language documents (26, 53) and storing the XML-language documents in a storage medium, searching for documents (55) according to a search query (13) having at least one term and identifying the documents (26) found in the search, and displaying the documents as nodes (33) of a tree structure (32) having links (34) and nodes (33) so as to indicate similarity of the documents to each other. |
| FILED | Wednesday, May 29, 2002 |
| APPL NO | 10/157704 |
| ART UNIT | 2167 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072890 | Salerno et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | John J. Salerno (Deerfield, New York); Douglas M. Boulware (Clinton, New York) |
| ABSTRACT | Method and apparatus to enable the parser component of a web search engine to adapt in response to frequent web page format changes at web sites. Parser “learns” from a set of defined HTTP links, how to find and parse web pages returned from a search engine query. The invention intelligently locates various token/strings that will correctly extract attributes associated with the returned item. Present invention may operate either automatically or in a user-assisted fashion. |
| FILED | Friday, February 21, 2003 |
| APPL NO | 10/371849 |
| ART UNIT | 2167 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/5 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07073157 | DeHon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | André DeHon (Pasadena, California); Charles M. Lieber (Lexington, Massachusetts) |
| ABSTRACT | An architecture for nanoscale electronics is disclosed. The architecture comprises arrays of crossed nanoscale wires having selectively programmable crosspoints. Nanoscale wires of one array are shared by other arrays, thus providing signal propagation between the arrays. Nanoscale signal restoration elements are also provided, allowing an output of a first array to be used as an input to a second array. Signal restoration occurs without routing of the signal to non-nanoscale wires. |
| FILED | Friday, January 17, 2003 |
| APPL NO | 10/347121 |
| ART UNIT | 2825 — Semiconductors/Memory |
| CURRENT CPC | Computer-aided design and analysis of circuits and semiconductor masks 716/17 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US H2159 | McGoldrick |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Daniel B. McGoldrick (Alexandria, Virginia) |
| ABSTRACT | A pair of vertical guide supports are slidably received in horizontally spaced rails removably mounted on a vertical target surface to be treated, such as the hull of a ship. A rack support interconnects the vertical guide supports and is vertically displaceable relative thereto with a rack plate thereby positioned in spaced relation to the target surface. A treatment device such as a pressurized paint ejector is positioned on the rack plate for selectively imposed movement therewith along linear paths to positions at which it is aligned perpendicular to the target surface to be completely treated by application or removal of paint for example. |
| FILED | Friday, January 16, 2004 |
| APPL NO | 10/758558 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Coating apparatus 118/305 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US H2161 | Scheps |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Richard Scheps (Rancho Sante Fe, California) |
| ABSTRACT | Visible light-emitting-diodes (LEDs) are inexpensive, provide emissions in many wavelengths and are powerful enough to pump solid state laser rods. The LED light is directed to the laser rod (laser gain element). The LED wavelength chosen matches the absorption spectrum of a transition element contained in the laser rod. It is know that the absorption bandwidths of these elements are typically very large. Besides a single LED, an array of LEDs may be used. Either of these arrangements may be imaged on the laser rod or fiber-coupled to the rod. A laser system that is pumped by one or more LEDs provides a low cost, relatively low power laser system. A low cost, higher powered, pulsed laser system is possible by pulsed LED operation. Thus it is possible to exceed the pump power threshold for a given laser by using a relatively small number of LEDs. |
| FILED | Tuesday, February 18, 2003 |
| APPL NO | 10/368946 |
| ART UNIT | 3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Coherent light generators 372/75 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US H2162 | Rivera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Rafael Rivera (Magnolia, New Jersey); Christopher Clemmer (Allentown, Pennsylvania) |
| ABSTRACT | A wheel supported conveyor having a central platform crane section disposed between opposite end crane sections is positioned in underlying relation to a container holding spreader of a dockside terminal crane for transfer of containers to and from the chassis of trucks moved into loading positions without obstruction along parallel spaced passage lanes formed in the end crane sections. Sections of a roller track are respectively associated with each of the conveyor crane sections for displacement of the containers laterally between a common track path and the truck passage lanes. Container spreaders are slidably mounted on the end crane sections effecting said lateral displacement of containers between the truck passage lanes and the common roller track path. |
| FILED | Friday, August 29, 2003 |
| APPL NO | 10/650679 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Material or article handling 414/139.900 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 07069999 | Hall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | IntelliServ, Inc. (Provo, Utah) |
| INVENTOR(S) | David R. Hall (Provo, Utah); H. Tracy Hall, Jr. (Provo, Utah); David S. Pixton (Lehi, Utah); Michael Briscoe (Lehi, Utah); Jay Reynolds (West Provo, Utah) |
| ABSTRACT | A method for routing a transmission line through a tool joint having a primary and secondary shoulder, a central bore, and a longitudinal axis, includes drilling a straight channel, at a positive, nominal angle with respect to the longitudinal axis, through the tool joint from the secondary shoulder to a point proximate the inside wall of the centtral bore. The method further includes milling back, from within the central bore, a second channel to merge with the straight channel, thereby forming a continuous channel from the secondary shoulder to the central bore. In selected embodiments, drilling is accomplished by gun-drilling the straight channel. In other embodiments, the method includes tilting the tool joint before drilling to produce the positive, nominal angle. In selected embodiments, the positive, nominal angle is less than or equal to 15 degrees. |
| FILED | Tuesday, February 10, 2004 |
| APPL NO | 10/708129 |
| ART UNIT | 3672 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Wells 166/380 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070359 | Richardson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | John G. Richardson (Idaho Falls, Idaho); Kevin M. Kostelnik (Idaho Falls, Idaho); Reva A. Nickelson (Shelley, Idaho); Paul A. Sloan (Rigby, Idaho) |
| ABSTRACT | A tunneling system including a tunneling apparatus including a cutting structure for forming a borehole and at least one linkage section for transmitting a force generally toward the cutting structure is disclosed. A method of disposing a casing string within a subterranean formation by applying a force generally to the trailing end of the tunneling apparatus, generally toward the leading end thereof, but without transmitting the entire force through the entire casing string is also disclosed. At least one linkage section extending within but not in contact with at least one casing section of the casing string may transmit the force. Also, a force limiting member may limit a force applied to the casing string. |
| FILED | Thursday, May 20, 2004 |
| APPL NO | 10/850706 |
| ART UNIT | 3672 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Hydraulic and earth engineering 45/141 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070755 | Klett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | James W. Klett (Knoxville, Tennessee); Timothy D. Burchell (Oak Ridge, Tennessee); Ashok Choudhury (Oak Ridge, Tennessee) |
| ABSTRACT | A thermally conductive carbon foam is provided, normally having a thermal conductivity of at least 40 W/m·K. The carbon foam usually has a specific thermal conductivity, defined as the thermal conductivity divided by the density, of at least about 75 W·cm3/m·° K·gm. The foam also has a high specific surface area, typically at least about 6,000 m2/m3. The foam is characterized by an x-ray diffraction pattern having “doublet” 100 and 101 peaks characterized by a relative peak split factor no greater than about 0.470. The foam is graphitic and exhibits substantially isotropic thermal conductivity. The foam comprises substantially ellipsoidal pores and the mean pore diameter of such pores is preferably no greater than about 340 microns. Other materials, such as phase change materials, can be impregnated in the pores in order to impart beneficial thermal properties to the foam. Heat exchange devices and evaporatively cooled heat sinks utilizing the foams are also disclosed. |
| FILED | Tuesday, January 29, 2002 |
| APPL NO | 10/059648 |
| ART UNIT | 1754 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Chemistry of inorganic compounds 423/448 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07070927 | Drmanac |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Radoje Drmanac (Palo Alto, California) |
| ABSTRACT | Disclosed are novel methods and compositions for rapid and highly efficient nucleic acid sequencing based upon hybridization with two sets of small oligonucleotide probes of known sequences. Extremely large nucleic acid molecules, including chromosomes and non-amplified RNA, may be sequenced without prior cloning or subcloning steps. The methods of the invention also solve various current problems associated with sequencing technology such as, for example, high noise to signal ratios and difficult discrimination, attaching many nucleic acid fragments to a surface, preparing many, longer or more complex probes and labelling more species. |
| FILED | Tuesday, February 05, 2002 |
| APPL NO | 10/068301 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071357 | Landis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Clark R. Landis (Madison, Wisconsin); Wiechang Jin (Madison, Wisconsin); Jonathan S. Owen (Pasadena, California); Thomas P. Clark (Madison, Wisconsin) |
| ABSTRACT | A diazaphosphacycle may be synthesized by reacting a phosphine with a diimine and optionally one or more equivalents of an acid halide, a sulfonyl halide, a phosphoryl halide, or an acid anhydride in the substantial absence of O2 to form the diazaphosphacycle. The phosphine has the formula R1—PH2 where R1 is a substituted or unsubstituted aryl group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted cycloalkyl group, or a substituted or unsubstituted ferrocenyl group. |
| FILED | Monday, July 23, 2001 |
| APPL NO | 09/911367 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 564/16 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071376 | Chapple et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Clinton C. S. Chapple (West Lafayette, Indiana); Rochus Franke (Kaiserslautern, Germany); Max O. Ruegger (Indianapolis, Indiana) |
| ABSTRACT | The present invention is directed to a method for altering secondary metabolism in plants, specifically phenylpropanoid metabolism. The present invention is further directed to a mutant p-coumarate 3-hydroxylase gene, referred to herein as the ref8 gene, its protein product which can be used to prepare gene constructs and transgenic plants. The gene constructs and transgenic plants are further aspects of the present invention. |
| FILED | Thursday, August 16, 2001 |
| APPL NO | 09/931267 |
| ART UNIT | 1638 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Multicellular living organisms and unmodified parts thereof and related processes 8/286 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071579 | Erdman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Global EnergyConcepts,LLC (Kirkland, Washington); William Erdman (Orinda, California) |
| INVENTOR(S) | William L. Erdman (Orinda, California); Terry M. Lettenmaier (Seattle, Washington) |
| ABSTRACT | An approach to wind farm design using variable speed wind turbines with low pulse number electrical output. The output of multiple wind turbines are aggregated to create a high pulse number electrical output at a point of common coupling with a utility grid network. Power quality at each individual wind turbine falls short of utility standards, but the aggregated output at the point of common coupling is within acceptable tolerances for utility power quality. The approach for aggregating low pulse number electrical output from multiple wind turbines relies upon a pad mounted transformer at each wind turbine that performs phase multiplication on the output of each wind turbine. Phase multiplication converts a modified square wave from the wind turbine into a 6 pulse output. Phase shifting of the 6 pulse output from each wind turbine allows the aggregated output of multiple wind turbines to be a 24 pulse approximation of a sine wave. Additional filtering and VAR control is embedded within the wind farm to take advantage of the wind farm's electrical impedence characteristics to further enhance power quality at the point of common coupling. |
| FILED | Monday, June 09, 2003 |
| APPL NO | 10/458588 |
| ART UNIT | 2834 — Electrical Circuits and Systems |
| CURRENT CPC | Prime-mover dynamo plants 290/55 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071595 | Schmid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Sandia National Laboratories (Livermore, California) |
| INVENTOR(S) | Andreas Schmid (Berkeley, California); Oliver Schaff (Berlin, Germany) |
| ABSTRACT | A positioning device provides the capability of moving an object in both a linear and a rotational direction. The positioning device includes a first piezo stack with plural piezo plates that are capable of movement in orthogonal directions with respect to each other. The positioning device further includes a second piezo stack with plural piezo plates that are capable of movement in orthogonal directions with respect to each other. The positioning device also includes a first bearing that is disposed against the first piezo stack. The positioning device further includes a second bearing that is disposed against the second piezo stack. The positioning device also includes a spring element and a fifth bearing that is disposed against the spring element. The first through fifth bearings are disposed around and against the object to be positioned, to provide for positioning of the object in at least one of a linear direction and a rotational direction. |
| FILED | Wednesday, December 15, 2004 |
| APPL NO | 11/015083 |
| ART UNIT | 2834 — Electrical Circuits and Systems |
| CURRENT CPC | Electrical generator or motor structure 310/323.170 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071841 | Haynes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Howard D. Haynes (Knoxville, Tennessee); Alfred Akerman (Knoxville, Tennessee); Curtis W. Ayers (Kingston, Tennessee) |
| ABSTRACT | A passive vehicle acoustic data analyzer system having at least one microphone disposed in the acoustic field of a moving vehicle and a computer in electronic communication the microphone(s). The computer detects and measures the frequency shift in the acoustic signature emitted by the vehicle as it approaches and passes the microphone(s). The acoustic signature of a truck driving by a microphone can provide enough information to estimate the truck speed in miles-per-hour (mph), engine speed in rotations-per-minute (RPM), turbocharger speed in RPM, and vehicle weight. |
| FILED | Thursday, August 19, 2004 |
| APPL NO | 10/922023 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Communications: Electrical 340/943 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072051 | Naqwi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Powerscope Incorporated (Minneapolis, Minnesota) |
| INVENTOR(S) | Amir A. Naqwi (Shoreview, Minnesota); Christopher W. Fandrey (Shoreview, Minnesota) |
| ABSTRACT | Size distribution of elongated objects is measured by forward scattering radiation from the objects at a range of scatter angles. The scattered radiation is refracted to locations on a scatter detector based on the scatter angles and independent of the location of the objects along the radiation axis. The intensity of radiation is sensed at each position on the scatter detector, and signals representative of the intensities at the positions are processed and compared to masks to identify a size distribution. The scatter detector may include individual radiation detectors arranged to receive refracted radiation representing respective ranges of scatter angles to thereby compensate for lower radiation intensities scattered from smaller objects. |
| FILED | Tuesday, April 15, 2003 |
| APPL NO | 10/413675 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/635 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072378 | Richardson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | John G. Richardson (Idaho Falls, Idaho); John L. Morrison (Butte, Montana); Grant L. Hawkes (Sugar City, Idaho) |
| ABSTRACT | An induction heating apparatus includes a measurement device for indicating an electrical resistance of a material to be heated. A controller is configured for energizing an inductor in response to the indicated resistance. An inductor may be energized with an alternating current, a characteristic of which may be selected in response to an indicated electrical resistance. Alternatively, a temperature of the material may be indicated via measuring the electrical resistance thereof and a characteristic of an alternating current for energizing the inductor may be selected in response to the temperature. Energizing the inductor may minimize the difference between a desired and indicated resistance or the difference between a desired and indicated temperature. A method of determining a temperature of at least one region of at least one material to be induction heated includes correlating a measured electrical resistance thereof to an average temperature thereof. |
| FILED | Wednesday, August 25, 2004 |
| APPL NO | 10/926899 |
| ART UNIT | 2832 — Optics |
| CURRENT CPC | Industrial electric heating furnaces 373/145 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072883 | Potok et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | UT-Battelle LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Thomas E. Potok (Oak Ridge, Tennessee); Mark Thomas Elmore (Oak Ridge, Tennessee); Joel Wesley Reed (Knoxville, Tennessee); Jim N. Treadwell (Louisville, Tennessee); Nagiza Faridovna Samatova (Oak Ridge, Tennessee) |
| ABSTRACT | A computer method of gathering and summarizing large amounts of information comprises collecting information from a plurality of information sources (14, 51) according to respective maps (52) of the information sources (14), converting the collected information from a storage format to XML-language documents (26, 53) and storing the XML-language documents in a storage medium, searching for documents (55) according to a search query (13) having at least one term and identifying the documents (26) found in the search, and displaying the documents as nodes (33) of a tree structure (32) having links (34) and nodes (33) so as to indicate similarity of the documents to each other. |
| FILED | Wednesday, May 29, 2002 |
| APPL NO | 10/157704 |
| ART UNIT | 2167 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 07071161 | Pisarchik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The University of Tennessee Research Corporation (Knoxville, Tennessee) |
| INVENTOR(S) | Alexander Pisarchik (Cordova, Tennessee); Andrzej Slominski (Germantown, Tennessee) |
| ABSTRACT | The present invention identifies four new isoforms of human corticotropin releasing hormone receptor type 1 (CRH-R1e, 1f, 1g and 1h) and three new isoforms of mouse corticotropin releasing hormone receptor type 1 (mCRH-R1c, 1e and 1f). The data indicate that polymorphism of CRH-R1 expression is related to anatomic location, skin physiological or pathologic status, specific cell type, external stress (UV), and that cAMP dependent pathways and TPA may regulate CRH-R1. |
| FILED | Friday, September 13, 2002 |
| APPL NO | 10/242822 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/12 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071277 | Kennedy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The University of Akron (Akron, Ohio) |
| INVENTOR(S) | Joseph P. Kennedy (Akron, Ohio); Pious Kurian (Aurora, Illinois) |
| ABSTRACT | A poly(cyclosiloxane) is synthesized by oxidation with water in the presence of a Pt catalyst, followed immediately by polycondensation of the Si—OH groups to form Si—O—Si linkages. Thus, pentamethylcyclopentasiloxane can be polymerized into poly(pentamethycyclopentasiloxane). |
| FILED | Wednesday, October 16, 2002 |
| APPL NO | 10/493146 |
| ART UNIT | 1712 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Synthetic resins or natural rubbers 528/15 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071464 | Reinhold |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Bruce Reinhold (Sudbury, Massachusetts) |
| ABSTRACT | The invention features a method including: i) confining ions to stable trajectories within an ion trap; ii) exciting a subset of the ions along at least one transverse coordinate; iii) rotating the transverse excitation into an excitation along an axial coordinate; and iv) transferring at least some of the axially excited ions from the ion trap along the axial coordinate. For example, the ions may be transferred to an ion detector or to a subsequent ion trap. |
| FILED | Monday, March 22, 2004 |
| APPL NO | 10/806933 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Radiant energy 250/282 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072547 | Assefa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Solomon Assefa (Cambridge, Massachusetts); Peter Bienstman (Gent, Belgium); Gale S. Petrich (Arlington, Massachusetts); Alexei A. Erchak (Cambridge, Massachusetts); Steven G. Johnson (St. Charles, Illinois); Leslie A. Kolodziejski (Belmont, Massachusetts); John D. Joannopoulos (Belmont, Massachusetts) |
| ABSTRACT | A coupling element includes a first stage having a dielectric waveguide that is transitioned to a waveguide having a sequence of resonators with a fixed period. A second stage transitions the waveguide to a photonic crystal waveguide by gradually bringing closer at an angle the cladding bulk of the photonic crystal to the waveguide. |
| FILED | Wednesday, June 18, 2003 |
| APPL NO | 10/464153 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical waveguides 385/39 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072707 | Galloway, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Robert L. Galloway, Jr. (Nashville, Tennessee); William C. Chapman (Nashville, Tennessee); James D. Stefansic (Nashville, Tennessee); Alan J. Herline (Nashville, Tennessee); Michael I. Miga (Franklin, Tennessee); David M. Cash (Nashville, Tennessee); Tuhin K. Sinha (Nashville, Tennessee) |
| ABSTRACT | A method and apparatus for collecting and processing physical space data used while performing image-guided surgery is disclosed. Physical space data is collected by probing physical surface points of surgically exposed tissue. The physical space data provides three-dimensional (3-D) coordinates for each of the physical surface points. Based on the physical space data collected, point-based registrations used to indicate surgical position in both image space and physical space are determined. In one embodiment, the surface of surgically exposed tissue of a living patient is illuminated with laser light. Light reflected from the illuminated surface of the exposed tissue is received and analyzed. In another embodiment, one or more magnetic fields of known shape and size are established in the proximity of the exposed tissue. Data associated with the strength of the magnetic fields is acquired and analyzed. |
| FILED | Wednesday, April 16, 2003 |
| APPL NO | 10/418187 |
| ART UNIT | 3737 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Surgery 6/424 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072811 | Kadane et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Joseph B. Kadane (Pittsburgh, Pennsylvania); Anthony E. Brockwell (Pittsburgh, Pennsylvania) |
| ABSTRACT | The method of the present invention is to modify an initial target distribution it π by combining it with a point mass concentrated on an “artificial atom” α which is outside the state-space X. A Markov chain may then be constructed using any known technique (for example, using the Metropolis-Hastings Algorithm) with the new target distribution. For this chain, the state α is Harris-recurrent (i.e. with probability one, it occurs infinitely many times). By the Markov property, the times at which the new chain hits α are regeneration times. To recover an ergodic chain with limiting distribution π, it is sufficient simply to delete every occurrence of the state α from the new chain. The points immediately after the (deleted) occurrences of the state α are then regeneration times in a Markov chain with limiting distribution π. |
| FILED | Monday, July 15, 2002 |
| APPL NO | 10/197356 |
| ART UNIT | 2128 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Structural design, modeling, simulation, and emulation 73/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 07070923 | Loftus |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (NASA) (Washington, District of Columbia) |
| INVENTOR(S) | David J. Loftus (Palo Alto, California) |
| ABSTRACT | System and method for enclosing cells and/or tissue, for purposes of growth, cell differentiation, suppression of cell differentiation, biological processing and/or transplantation of cells and tissues (biological inserts), and for secretion, sensing and monitoring of selected chemical substancesand activation of gene expression of biological inserts implanted into a human body. Selected cells and/or tissue are enveloped in a “cage” that is primarily carbon nanotube Bucky paper, with a selected thickness and porosity. Optionally, selected functional groups, proteins and/or peptides are attached to the carbon nanotube cage, or included within the cage, to enhance the growth and/or differentiation of the cells and/or tissue, to select for certain cellular sub-populations, to optimize certain functions of the cells and/or tissue and/or to optimize the passage of chemicals across the cage surface(s). A cage system is also used as an immuns shield and to control operation of a nano-device or macroscopic device, located within the cage, to provide or transform a selected chemical and/or a selected signal. |
| FILED | Thursday, June 26, 2003 |
| APPL NO | 10/608884 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/4 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071741 | Palumbo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Daniel L. Palumbo (Newport News, Virginia) |
| ABSTRACT | A method and system utilize a processor's digital timer and two interrupts to form a frequency multiplier. The first interrupt's processing time window is definable by a first number of counts C1 of the digital timer while the second interrupt's processing time window is definable by a second number of counts C2 of the digital timer. A count value CV utilized by the system/method is based on a desired frequency multiplier N, the timer clock rate, and the time required for one cycle of an input signal. The first interrupt is triggered upon completion of one cycle of the input signal at which point the processing time window associated therewith begins. The second interrupt is triggered each time the timer's overflow signal is generated at which point the processing time window associated with the second interrupt begins. During the occurrence of the second interrupt's processing, the count value CV is modified to maintain the first interrupt's processing time window approximately centered between two of the second interrupt's processing time windows. |
| FILED | Friday, September 17, 2004 |
| APPL NO | 10/943825 |
| ART UNIT | 2816 — Semiconductors/Memory |
| CURRENT CPC | Miscellaneous active electrical nonlinear devices, circuits, and systems 327/116 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072814 | Stoica |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Adrian Stoica (Altadena, California) |
| ABSTRACT | A method of evolving a circuit uses a heterogenous mix of models of both high and low levels of resolution. |
| FILED | Tuesday, January 29, 2002 |
| APPL NO | 10/061066 |
| ART UNIT | 2128 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Structural design, modeling, simulation, and emulation 73/13 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07072874 | Decker |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Arthur J. Decker (North Olmstead, Ohio) |
| ABSTRACT | An artificial neural network is disclosed that processes holography generated characteristic patterns of vibrating structures along with finite-element models. The present invention provides for a folding operation for conditioning training sets for optimally training forward-neural networks to process characteristic fringe patterns. The folding pattern increases the sensitivity of the feed-forward network for detecting changes in the characteristic pattern. The folding routine manipulates input pixels so as to be scaled according to the location in an intensity range rather than the position in the characteristic pattern. |
| FILED | Tuesday, April 01, 2003 |
| APPL NO | 10/404725 |
| ART UNIT | 2129 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Artificial intelligence 76/25 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 07070929 | Tuggle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa); Pig Inprovement Company UK Limited (, United Kingdom); The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Christopher K. Tuggle (Ames, Iowa); Thomas J. Stabel (Ames, Iowa); Xianwei Shi (Kunming, China PRC); Martha A. Mellencamp (St. Joseph, Missouri) |
| ABSTRACT | A method for determining improved disease resistance in animals is disclosed. The method assays for a novel genetic alleles of the BPI gene of the animal. The alleles are correlated with superior disease resistance. Novel nucleotide sequences, assays and primers are disclosed for the methods of the invention. |
| FILED | Friday, May 31, 2002 |
| APPL NO | 10/161968 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071003 | Hutchens et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | T. William Hutchens (Houston, Texas); Tai-Tung Yip (Sugar Land, Texas) |
| ABSTRACT | This invention is directed to probes that are removably insertable into mass spectrometers. The probes have sample presenting surfaces, at least, that contain non-metallic materials. The probes are useful in methods of desorbing analytes from the probe surface. The invention also is directed to detection systems that include the probes and methods of detecting analytes using the system. |
| FILED | Monday, July 27, 1998 |
| APPL NO | 09/123253 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/155 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 07072514 | Thouin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the National Security Agency (Washington, District of Columbia) |
| INVENTOR(S) | Paul D. Thouin (Eldersburg, Maryland) |
| ABSTRACT | The present invention is a method of categorizing an image as handwritten, machine-printed, and unknown. First, the image is received. Next, connected components are identified. Next, a bounding box encloses each connected component. Next, a height and width is computed for each bounding box. Next, a sum and maximum horizontal run for each connected component are computed. Next, connected components that are suspected of being characters are identified. If the number of suspected characters is less than or equal to a first user-definable number then the image is categorized as unknown. If the number of suspected characters is greater than the first user-definable number then determine if matches exist amongst the suspected characters. Next, compute a score based on the suspected characters and the number of matches and categorize the image as either handwritten, machine-printed, or unknown. |
| FILED | Thursday, February 06, 2003 |
| APPL NO | 10/361036 |
| ART UNIT | 2624 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/187 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07073196 | Dowd et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the National Security Agency (Washington, District of Columbia) |
| INVENTOR(S) | Patrick W. Dowd (Columbia, Maryland); John T. McHenry (Odenton, Maryland) |
| ABSTRACT | The present invention is a device for and method of accessing a network by initializing a database, an approved list, and a disapproved list; receiving an connectionless network packet; computing a flow tag based on the connectionless network packet; discarding the connectionless network packet and returning to the second step if the flow tag is on the disapproved list; allowing access to the network and returning to the second step if the flow tag is on the approved list; comparing the flow tag to the database if the flow tag is not on the approved list or the disapproved list; discarding the connectionless network packet, adding the flow tag to the disapproved list, and returning to the second step if the database rejects the flow tag; and allowing access to the network, adding the flow tag to the approved list, and returning to the second step if the database accepts the flow tag. |
| FILED | Wednesday, April 07, 1999 |
| APPL NO | 09/287654 |
| ART UNIT | 2131 — Semiconductors/Memory |
| CURRENT CPC | Information security 726/14 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 07070739 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Large Scale Proteomics Corporation (Vacaville, California) |
| INVENTOR(S) | Norman G. Anderson (Rockville, Maryland); N. Leigh Anderson (Washington, District of Columbia) |
| ABSTRACT | A method for separating microorganisms, especially infectious agents, from a mixture by two dimensional centrifugation on the basis of sedimentation rate and isopycnic banding density, for sedimenting such microorganisms through zones of immobilized reagents to which they are resistant, for detecting banded particles by light scatter or fluorescence using nucleic acid specific dyes, and for recovering the banded particles in very small volumes for characterization by mass spectrometry of viral protein subunits and intact viral particles, and by fluorescence flow cytometric determination of both nucleic acid mass and the masses of fragments produced by restriction enzymes. The method is based on the discovery that individual microorganisms, such as bacterial and viral species, are each physically relatively homogeneous, and are distinguishable in their biophysical properties from other biological particles, and from non-biological particles found in nature. The method is useful for distinguishing infections, for identifying known microorganisms, and for discovering and characterizing new microorganisms. The method provides very rapid identification of microorganisms, and hence allows a rational choice of therapy for identified infectious agents. A particularly useful application is in clinical trials of new antibiotics and antivirals, where it is essential to identify at the outset individuals infected with the targeted infectious agent. |
| FILED | Tuesday, May 16, 2000 |
| APPL NO | 09/571290 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing 422/82.50 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071431 | Ruan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Meichun Ruan (Tempe, Arizona); Jun Shen (Phoenix, Arizona); Charles Wheeler (Paradise Valley, Arizona) |
| ABSTRACT | A switch with an open state and a closed state suitably includes a cantilever having first and second states corresponding to the open and closed states of the switch, respectively. The switch may also include a magnet configured to provide an electromagnetic field that maintains said cantilever in one of the first and second states. Various embodiments may also include an electrode or electrical conductor configured to provide an electric potential or electromagnetic pulse, as appropriate, to switch the cantilever between the first and second states. Various embodiments may be formulated with micromachining technologies, and may be formed on a substrate. |
| FILED | Tuesday, March 06, 2001 |
| APPL NO | 09/799746 |
| ART UNIT | 2833 — Electrical Circuits and Systems |
| CURRENT CPC | Electricity: Circuit makers and breakers 2/181 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 07072731 | Barto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Advanced Micro Devices (Sunnyvale, California) |
| INVENTOR(S) | Larry D. Barto (Austin, Texas); Steven C. Nettles (Johnson City, Texas); Yiwei Li (Austin, Texas) |
| ABSTRACT | A system and method are provided for monitoring work in process (“WIP”) in a manufacturing facility. The system and method utilize software objects to identify a bottleneck workstation and calculate a WIP value representing the amount of work approaching the bottleneck workstation. If it is determined that the WIP value for a bottleneck workstation is projected to fall below a control limit during the evaluation period, an additional amount of work is released into the manufacturing line. In this manner, new work is introduced to a bottleneck station in order to prevent bottleneck starvation. Various embodiments provide for multiple products and multiple bottleneck workstations. |
| FILED | Tuesday, April 03, 2001 |
| APPL NO | 09/825225 |
| ART UNIT | 2125 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Generic control systems or specific applications 7/102 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 07069747 | DeSmitt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | ITT Manufacturing Enterprises, Inc. (Wilmington, Delaware) |
| INVENTOR(S) | Steven M. DeSmitt (Fairport, New York); David N. Strafford (Pittsford, New York); Joseph R. West (Webster, New York) |
| ABSTRACT | A method for constructing a mirror blank, including arranging hollow glass balls, on a front face sheet, and in close proximity to each other to permit fusing upon expansion; restricting the expansion of the hollow glass balls with a bounding structure during expansion of the hollow glass balls to force the hollow glass balls into a densely packed array of cells; applying heat to soften the hollow glass balls and increase the pressure within the hollow glass balls as the hollow glass balls fuse with each other during expansion, forming cells, wherein as a result of fusing, the hollow glass balls contact the front face sheet as a result of the increased pressure within the hollow glass balls; annealing and cooling the mirror blank to below annealing temperature associated with the hollow glass balls; and venting the cells. |
| FILED | Monday, December 23, 2002 |
| APPL NO | 10/328524 |
| ART UNIT | 1731 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Glass manufacturing 065/21.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 07071162 | Narayanan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | |
| INVENTOR(S) | A. Sampath Narayanan (Seattle, Washington); Sandu Pitaru (Ramat Gan, 52290, Tel Aviv, Israel); Roy C. Page (Seattle, Washington); Anthony C. Allison (Belmont, California) |
| ABSTRACT | A method is described for inducing the formation of cementum and a periodontal ligament between a dental implant and bone by administering cementum attachment protein (CAP) together with a calcineurin inhibitor such as cyclosporin A (CSA). Also contemplated is an implant kit comprising a titanium or other biologically inert dental or orthopedic implant and a coating of CAP and a calcineurin inhibitor such as CSA. Furthermore, application of CAP and CSA to dental root surfaces can be used to induce the regeneration of a periodontal ligament during treatment for periodontal disease. A similar method for reattaching a fibrous structure, such as a tendon, ligament or joint capsule, to bone is described. |
| FILED | Wednesday, April 09, 2003 |
| APPL NO | 10/410762 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/12 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07071194 | Teng |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Yang D. Teng (Wellesley, Massachusetts) |
| ABSTRACT | The present invention provides a method for improving respiratory function and inhibiting muscular degeneration (e.g., dystrophy and atrophy). Alternative embodiments of the invention provide a method of inhibiting motor neuron apoptosis and the subsequent muscular degeneration associated with the denervation of muscular tissue resulting from neuron death. |
| FILED | Friday, September 13, 2002 |
| APPL NO | 10/244087 |
| ART UNIT | 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/252.150 |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, July 04, 2006.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2006/fedinvent-patents-20060704.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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