FedInvent™ Patents
Patent Details for Tuesday, October 05, 2010
This page was updated on Monday, March 27, 2023 at 01:54 AM GMT
Department of Health and Human Services (HHS)
| US 07806528 | Bedell et al. |
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| ASSIGNEE(S) | The University of Houston System (Houston, Texas) |
| INVENTOR(S) | Harold E. Bedell (Houston, Texas); Jianliang Tong (Houston, Texas); Stanley Y Woo (Houston, Texas) |
| ABSTRACT | Provided herein are methods and systems to screen for subjects at risk for retinal-associated eye diseases or to monitor the progression/regression thereof. Generally, the method comprises simultaneously or sequentially displaying to a potentially at-risk individual targets of parallel and nonparallel lines, obtaining an orientation discrimination threshold based on the subject's selections and correlating an increase in the threshold compared to that of a normal control or to a previous threshold measured for the subject as indicative of risk for a retinal-associated eye disease or a progression of the eye disease. Also provided are program storage devices and computer program products effective to store instructions or source code to perform the methods. |
| FILED | Wednesday, December 05, 2007 |
| APPL NO | 11/999395 |
| ART UNIT | 2873 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Optics: Eye examining, vision testing and correcting 351/211 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807135 | Kung et al. |
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| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Hank F. Kung (Wynnewood, Pennsylvania); Mei-Ping Kung (Wynnewood, Pennsylvania); Zhi-Ping Zhuang (Lansdale, Pennsylvania) |
| ABSTRACT | This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits. |
| FILED | Monday, December 19, 2005 |
| APPL NO | 11/305333 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/1.890 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807137 | Raptis et al. |
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| ASSIGNEE(S) | University of Puerto Rico (San Juan, Puerto Rico) |
| INVENTOR(S) | Raphael G. Raptis (San Juan, Puerto Rico); Ricardo González-Méndez (San Juan, Puerto Rico) |
| ABSTRACT | A contrast agent having a metal core and an inert shell forming a single cluster is disclosed. The metal core is iron-based and has an octa-nuclear structure. It is surrounded by a cluster of pyrazolate groups. Ligands can be attached to the cluster to provide water solubility and to target specific tissues or provide specific contrast properties. |
| FILED | Tuesday, February 14, 2006 |
| APPL NO | 11/354064 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/9.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807138 | Berger et al. |
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| ASSIGNEE(S) | Metabolon, Inc. (Durham, North Carolina) |
| INVENTOR(S) | Alvin Berger (Raleigh, North Carolina); Imran A. Shah (Chapel Hill, North Carolina) |
| ABSTRACT | Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring of drug efficacy. |
| FILED | Friday, August 17, 2007 |
| APPL NO | 11/840466 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/9.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807140 | Kiessling et al. |
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| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Laura L. Kiessling (Madison, Wisconsin); Ronald T. Raines (Madison, Wisconsin); Matthew J. Allen (Madison, Wisconsin) |
| ABSTRACT | Polymeric chelating agents and metal chelates, particularly those of lanthanide metals and more specifically those of Gd(III), useful as contrast agents in magnetic resonance imaging (MRI) for therapeutic and diagnostic applications as well as clinical and biomedical research applications. The polymeric chelates are generated using ring-opening metathesis polymerization (ROMP). Polymers can have multiple sites for functionalization allowing for the synthesis of multimodal and targeted contrast agents. Hydroxypyridonate (HOPO)-based chelating moieties are integrated into a ROMP-derived polymer. More specifically, the HOPO-based chelating moiety is integrated into a benzonorbornadiene unit that constitutes the backbone of the polymer. The ROMP-derived polymer chelators can comprise multiple metal ions, particularly Gd(III) ions, in polymers of varying lengths to provide a series of agents with controlled relaxivites. Polymer chelates include those that are water-soluble. |
| FILED | Thursday, May 03, 2007 |
| APPL NO | 11/743740 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/9.365 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807145 | Goldman et al. |
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| ASSIGNEE(S) | Cornell Research Foundation, Inc. (Ithaca, New York) |
| INVENTOR(S) | Steven A. Goldman (Webster, New York); Abdellatif Benraiss (Astoria, New York) |
| ABSTRACT | The present invention relates to methods of inducing neuronal production in the brain, recruiting neurons to the brain, and treating a neurodegenerative condition by providing a nucleic acid construct encoding a neurotrophic factor, and injecting the nucleic acid construct intraventricularly into a subject's brain. |
| FILED | Monday, April 03, 2006 |
| APPL NO | 11/397036 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807147 | Meruelo |
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| ASSIGNEE(S) | New York University (New York, New York) |
| INVENTOR(S) | Daniel Meruelo (Scarborough, New York) |
| ABSTRACT | The present invention relates to methods and compositions for treating tumors using vectors that preferentially target tumor cells. In particular, the invention relates to alphavirus-based, preferably Sindbis virus-based, vectors and to non-alphavirus-based vectors, which have a preferential affinity for high affinity laminin receptors (HALR). These vectors are efficiently targeted to tumors and have the ability to cause tumor necrosis. |
| FILED | Tuesday, October 30, 2007 |
| APPL NO | 11/928564 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807148 | Comer et al. |
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| ASSIGNEE(S) | Stratatech Corporation (Madison, Wisconsin) |
| INVENTOR(S) | Allen Comer (Madison, Wisconsin); Lynn-Allen Hoffmann (Madison, Wisconsin) |
| ABSTRACT | The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue. |
| FILED | Wednesday, May 19, 2004 |
| APPL NO | 10/848646 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807156 | Croft et al. |
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| ASSIGNEE(S) | La Jolla Institute for Allergy and Immunology (La Jolla, California) |
| INVENTOR(S) | Michael Croft (San Diego, California); Shahram Salek-Ardakani (San Diego, California) |
| ABSTRACT | T cell memory can persist in the absence of antigen. However, some memory cells by default are subject to signals accompanying periodic antigen exposure. OX40 is essential to the extent and persistence of Th2 memory when antigen is re-encountered. In an animal model of allergic asthma, inhibiting OX40/OX40L signaling during the secondary response to inhaled antigen suppressed lung inflammation. Inhibiting OX40 at the time of memory cell reactivation reduced the longevity of memory with further inflammation prevented upon tertiary encounter with antigen. |
| FILED | Tuesday, October 16, 2007 |
| APPL NO | 11/873149 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/130.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807166 | Rodriguez et al. |
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| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Moses Rodriguez (Rochester, Minnesota); David J. Miller (Ridgeway, Wisconsin); Larry R. Pease (Rochester, Minnesota) |
| ABSTRACT | Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. The neuromodulatory agent has one or more of the following characteristics: it is capable of inducing remyelination; binding to neural tissue; promoting Ca−− signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22 (LYM 22), sHIgm46 (LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in diagnostic and therapeutic applications, including screening assays for the discovery of additional antibodies that bind to cells of the nervous system, particularly oligodendrocytes. |
| FILED | Thursday, November 20, 2008 |
| APPL NO | 12/313515 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/141.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807174 | Fang et al. |
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| ASSIGNEE(S) | NexBio, Inc. (San Diego, California); The United States of America/NIH (Washington, District of Columbia) |
| INVENTOR(S) | Fang Fang (San Diego, California); Michael Malakhov (San Diego, California) |
| ABSTRACT | The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy. |
| FILED | Friday, September 10, 2004 |
| APPL NO | 10/939262 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/192.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807180 | Lu et al. |
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| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Shan Lu (Hopkinton, Massachusetts); Pavlo Sakhatskyy (Worcester, Massachusetts); Shixia Wang (Northborough, Massachusetts) |
| ABSTRACT | Methods and compositions for inducing immune responses against poxviruses are disclosed. The compositions include nucleic acids that encode modified vaccinia and variola antigens. Compositions that include recombinant vaccinia and variola polypeptides are also disclosed. |
| FILED | Tuesday, August 21, 2007 |
| APPL NO | 11/842761 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/232.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807181 | Stephens et al. |
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| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | David S. Stephens (Stone Mountain, Georgia); Yih-Ling Tzeng (Atlanta, Georgia); Susu Zughaier (Atlanta, Georgia); Shanta Zimmer (Atlanta, Georgia) |
| ABSTRACT | Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A molecules from a Neisseria strain containing a genetically stable mutation which inactivates a gene selected from the group consisting of genes encoding arabinose-5-phosphate isomerase, CMP-Kdo synthetase and CMP-Kdo transferase. N. meningitidis NMB206 is a specifically exemplified strain which harbors a stable insertion mutation in the gene (kpsF) encoding A5P isomerase; strain NMB-249 is a specifically exemplified strain with a stable insertion mutation in the gene (kdtA) encoding CMP-Kdo synthetase, and strain NMB259 is specifically exemplified strain with a stable insertion mutation in the gene (kdsB) encoding CMP-Kdo transferase. Also provided by the present invention are methods for the production of Lipid A flee of 3-keto-3-deoxyoctanoic acid using these genetically stable N. meningitidis mutants. Also describes is pYT250, a plasmid functional in neisseriae and in enterics such as Escherichia coli. |
| FILED | Thursday, March 20, 2003 |
| APPL NO | 10/508309 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/234.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807182 | Laal et al. |
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| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado); New York University (New York, New York) |
| INVENTOR(S) | Suman Laal (Croton-on-Hudson, New York); Susan Zolla-Pazner (New York, New York); John T. Belisle (Fort Collins, Colorado) |
| ABSTRACT | A number of protein and glycoprotein antigens secreted by Mycobacterium tuberculosis (Mtb) have been identified as “early” Mtb antigens on the basis early antibodies present in subjects infected with Mtb prior to the development of detectable clinical disease. Epitope-bearing peptide fragments of these early Mtb antigens, in particular of an 88 kDa secreted protein, GlcB (SEQ ID NO:106) and of Mtb antigen MPT51 (SEQ ID NO:107) have been identified. These peptides, variants thereof, peptide multimers thereof that include two or more repeats of one or more of the peptides, and fusion polypeptides that include early Mtb antigenic proteins, peptides or both, are useful in immunoassay methods for early, rapid detection of TB in a subject. Preferred immunoassays detect the antibodies in the subject's urine. Also provided are antigenic compositions, kits and methods to useful for detecting an early Mtb antibodies. The antigenic proteins and peptides are also used in vaccine compositions. |
| FILED | Friday, August 02, 2002 |
| APPL NO | 10/210884 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/248.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807186 | Ostrand-Rosenberg et al. |
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| ASSIGNEE(S) | University of Maryland, Baltimore County (Baltimore, Maryland) |
| INVENTOR(S) | Suzanne Ostrand-Rosenberg (Columbia, Maryland); Jacobus J. Bosch (Baltimore, Maryland); Bruce R. Ksander (Belmont, Massachusetts) |
| ABSTRACT | The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encoded tumor antigens, activate CD4+ T-lymphocytes, provide an array of antigens to which the host is not tolerized and/or induce immunity against the originating tumor cells as well as against metastatic tumor cells. |
| FILED | Wednesday, January 16, 2008 |
| APPL NO | 12/015116 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/277.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807187 | Rock et al. |
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| ASSIGNEE(S) | The University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Kenneth L. Rock (Chestnut Hill, Massachusetts); Yan Shi (Auburn, Massachusetts) |
| ABSTRACT | Methods of modulating the immune response using pharmaceutical compositions containing crystalline adjuvants are described. In various embodiments the crystalline adjuvants are selected from the group consisting of monosodium urate (MSU), xanthine, basic calcium phosphate (BCP), calcium pyrophosphate dihydrate (CPPD), hydroxyapatite, calcium oxalate, cholesterol, lipid liquid, other crystalline lipids, lithium heparin, talc, and starch. |
| FILED | Thursday, May 13, 2004 |
| APPL NO | 10/846381 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/278.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807358 | Huang |
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| ASSIGNEE(S) | Curators of the University of Missouri (Columbia, Missouri) |
| INVENTOR(S) | Timothy Hui-Ming Huang (Columbus, Ohio) |
| ABSTRACT | The present invention provides a method of hybridization, differential methylation hybridization (DMH) for high throughput methylation analysis of multiple CpG island loci. DMH utilizes nucleic acid probes prepared from a cell sample to screen numerous CpG dinucleotide rich fragments affixed on a screening array. Positive hybridization signals indicate the presence of methylated sites. Methods of preparing the hybridization probes and screening array are also provided. |
| FILED | Friday, July 28, 2006 |
| APPL NO | 11/496073 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807362 | Kim et al. |
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| ASSIGNEE(S) | The McLean Hospital Corporation (Belmont, Massachusetts) |
| INVENTOR(S) | Kwang-Soo Kim (Lexington, Massachusetts); Chun-Hyung Kim (Lexington, Massachusetts) |
| ABSTRACT | This invention features methods and compositions useful for the treatment and diagnosis of attentional disorders including attention deficit hyperactivity disorder (ADHD). Also disclosed are methods for identifying compounds useful for such therapy. |
| FILED | Wednesday, February 14, 2007 |
| APPL NO | 11/674817 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807364 | Lenz |
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| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Heinz-Josef Lenz (Altadena, California) |
| ABSTRACT | A method for determining whether a patient in need thereof will respond to anti-VEGF antibody based chemotherapy by screening a suitable cell or tissue sample isolated from the patient for at least one genomic polymorphism or genotype selected from (i) IL-8(−251); (ii) VEGF(936); or (iii) AM (3′ CA repeats), wherein the patient is suitably treated if the corresponding genotype is (i) (T/T) for IL-8(−251); (ii) (T/T or C/T) for VEGF(936); or (iii) at least one AM allele having 14 or more 3′ CA repeats. |
| FILED | Friday, March 02, 2007 |
| APPL NO | 11/681695 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807366 | Strauss, III et al. |
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| ASSIGNEE(S) | Virginia Commonwealth University (Richmond, Virginia) |
| INVENTOR(S) | Jerome F. Strauss, III (Richmond, Virginia); Hongyan Wang (Shanghai, China PRC) |
| ABSTRACT | A method to identify women who are at risk for preterm delivery due to premature rupture of membranes (PPROM) is provided. The method entails detecting the presence of SERPINH1 gene variants that express low levels of the gene product, heat shock protein Hsp47. The occurrence of a T (rather than C) at a single nucleotide polymorphism (SNP) site at position −656 of the SERPINH1 gene promoter, together with the absence of a 12 base pair deletion at positions −694 to −683 of the promoter, result in an increased risk of PPROM. The method enables medical professionals to identify those at risk, and to provide suitable therapeutic intervention. |
| FILED | Thursday, April 12, 2007 |
| APPL NO | 11/734383 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807372 | Mirkin et al. |
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| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Sarah J. Hurst (Evanston, Illinois); Min Su Han (Kyung-Buk, South Korea); Abigail K. R. Lytton-Jean (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are methods of screening sequence selectivity of oligonucleotide-binding molecules using a gold nanoparticle based colorimetric assay. |
| FILED | Wednesday, June 04, 2008 |
| APPL NO | 12/133243 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807374 | Richardson et al. |
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| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Bruce Richardson (Ann Arbor, Michigan); Qianjin Lu (Ann Arbor, Michigan) |
| ABSTRACT | The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases. |
| FILED | Monday, October 20, 2008 |
| APPL NO | 12/254550 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807377 | Albani |
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| ASSIGNEE(S) | Salvatore Albani (Tuscon, Arizona) |
| INVENTOR(S) | Salvatore Albani (San Diego, California) |
| ABSTRACT | The present invention concerns artificial antigen presenting cells (aAPCs) and methods of making and using the same, for example, to isolate, identify, and expand T cell populations specifically reactive against a disease-associated antigenic peptide, as well as to modulate responses of antigen-specific T cells both in vivo, ex vivo, and in vitro. Accordingly, the aAPCs of the invention can be used to treat conditions that would benefit from modulation of a T cell response, for example, autoimmune disorders, allergies, cancers, viral infections, and graft rejection. In certain preferred embodiments, the aAPCs are liposomes comprised of MHC:peptide complexes and accessory molecules. Other molecules, such as co-stimulatory molecules and adhesion molecules, can also be included in the compositions of the invention. In other embodiments, the aAPCs are comprised of a scaffold to which a plurality of MHC:peptide complexes and accessory molecules (as well as other molecules) can be attached at high density. |
| FILED | Wednesday, October 06, 2004 |
| APPL NO | 10/960855 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807381 | Bibb et al. |
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| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | James A. Bibb (Dallas, Texas); Ammar H. Hawasli (Dallas, Texas) |
| ABSTRACT | As described herein, signaling events occurring in neurons or at neuronal synapses have been identified that involve Cdk5 and various other molecules which bind to, are activated by, and/or activate Cdk5. Of particular relevance are interactions that stimulate calpain cleavage of p35 into p25, which binds Cdk5 in pathologic states. Assays to identify modulators of these interactions are provided. |
| FILED | Friday, May 25, 2007 |
| APPL NO | 11/754097 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807383 | Boyer et al. |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Thomas G. Boyer (San Antonio, Texas); Amy M. Trauernicht (Chula Vista, California) |
| ABSTRACT | Provided herein are methods and compositions related to diagnosing and treating hormone resistant cancers. |
| FILED | Thursday, April 17, 2008 |
| APPL NO | 12/104709 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807389 | Ritchlin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Christopher T. Ritchlin (Canadagua, New York); Sally A. Haas-Smith (Ridgefield, Connecticut); Edward M. Schwarz (Rochester, New York) |
| ABSTRACT | Disclosed are compositions and methods related to joint inflammation diseases. Disclosed is the relationship between osteoclasts and inflammatory joint diseases and osteoclast precursor cells. |
| FILED | Friday, March 12, 2004 |
| APPL NO | 10/799345 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807396 | Hersh |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Kentucky Research Foundation (, None) |
| INVENTOR(S) | Louis B. Hersh (Lexington, Kentucky) |
| ABSTRACT | Estrogen has been shown to increase the expression and activity of amyloid peptide inactivating enzymes in the brain. Peptides have been shown to increase the activity of an amyloid peptide inactivating enzyme. Methods of identifying compounds for, and methods of treating patients with, Alzheimer's Disease is disclosed. |
| FILED | Tuesday, June 03, 2003 |
| APPL NO | 10/513470 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.720 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807405 | Wang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Maryland Baltimore, Office of Commercial Ventures and Intellectual Property (Baltimore, Maryland) |
| INVENTOR(S) | Lai-Xi Wang (Ellicott City, Maryland) |
| ABSTRACT | A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of a catalyst comprising endoglycosidase (ENGase), to transfer the oligosaccharide moiety to the acceptor and yield the homogeneous glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline. A related method of glycoprotein or glycopeptide remodeling with a predetermined natural N-glycan or a tailor-made oligosaccharide moiety, and a method of remodeling an antibody including a heterogeneous sugar chain, are also described. The disclosed methodology enables glycoprotein drugs to be modified for prolonged half-life in vivo, reduced immunogenicity, and enhanced in vivo activity, and for targeting and drug delivery. |
| FILED | Friday, June 08, 2007 |
| APPL NO | 11/760434 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/68.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807431 | Barany et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Cornell Research Foundation, Inc. (Ithaca, New York) |
| INVENTOR(S) | Francis Barany (New York, New York); Weiguo Cao (Central, South Carolina); Jianmin Huang (Jackson Heights, New York); Jing Lu (Tucker, Georgia) |
| ABSTRACT | The present invention is a method for detecting DNA sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide deletions. Labeled heteroduplex PCR fragments containing base mismatches are prepared. Endonuclease cleaves the heteroduplex PCR fragments both at the position containing the variation (one or more mismatched bases) and to a lesser extent, at non-variant (perfectly matched) positions. Ligation of the cleavage products with a DNA ligase corrects non-variant cleavages and thus substantially reduces background. This is then followed by a detection step in which the reaction products are detected, and the position of the sequence variations are determined. |
| FILED | Monday, March 05, 2007 |
| APPL NO | 11/682172 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/199 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807462 | Rameshwar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Medicine and Dentistry of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Pranela Rameshwar (Maplewood, New Jersey) |
| ABSTRACT | The present invention relates to the production of functional neurons from adult human mesenchymal stem cells using a retinoid. A retinoid, when used in the absence of a growth factor, transdifferentiates mesenchymal stem cells into functional neurons that exhibit synaptic transmission. Moreover, polarization of the functional neurons can be achieved using selected growth factors. Functional neurons produced in accordance with the method of the invention find use in the treatment or amelioration of diseases or conditions associated with neurodegeneration or nerve damage. |
| FILED | Tuesday, November 15, 2005 |
| APPL NO | 11/274004 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/368 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807464 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| INVENTOR(S) | Chengcheng Zhang (Arlington, Massachusetts); Harvey F. Lodish (Brookline, Massachusetts) |
| ABSTRACT | Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions sufficient for expansion of HSCs. Angiopoietin-like proteins include angiopoietin-like protein 2, angiopoietin-like protein 3, angiopoietin-like protein 4, angiopoietin-like protein 5, angiopoietin-like protein 7, and microfibrillar-associated glycoprotein (Mfap4). Methods for identifying hematopoietic stem cells are provided and isolated hematopoietic stem cells are also provided. |
| FILED | Tuesday, May 23, 2006 |
| APPL NO | 11/438847 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/377 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807465 | Vance et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Jeffery M. Vance (Chapel Hill, North Carolina); Pascal J. Goldschmidt (Chapel Hill, North Carolina); Simon S. Gregory (Durham, North Carolina); William E. Kraus (Hillsborough, North Carolina); Elizabeth R. Hauser (Durham, North Carolina) |
| ABSTRACT | The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31. |
| FILED | Thursday, October 27, 2005 |
| APPL NO | 11/260842 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807472 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Xia Xu (Frederick, Maryland); Regina G. Ziegler (Bethesda, Maryland); David J. Waterhouse (Frederick, Maryland); Joseph E. Saavedra (Thurmont, Maryland); Larry K. Keefer (Bethesda, Maryland) |
| ABSTRACT | Methods for enhancing detection by mass spectroscopy (MS) and/or chromatographic separability of carbonyl-containing compounds such as steroids are disclosed. Reaction of a carbonyl compound with a sulfonhydrazide compound provides a sulfonhydrazone with enhanced ionization efficiency during the electrospray ionization process. In a particularly disclosed embodiment, derivatization of catechol estrogens with p-toluenesulfonhydrazide enhances both detection by atmospheric pressure ionization-MS (API-MS), such as electron spray ionization-MS (ESI-MS) and separation by liquid chromatography (such as HPLC) under reverse phase conditions. In yet other embodiments, the sulfonhydrazone is further reacted with a sulfonyl halide under alkaline conditions to derivatize hydroxyl groups in the compound. Prior formation of the sulfonhydrazide derivative protects the carbonyl bond of the compound during subsequent alkaline reaction with the sulfonyl halide. |
| FILED | Tuesday, April 15, 2003 |
| APPL NO | 10/511409 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/87 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807474 | Jesmanowicz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | MCW Research Foundation, Inc. (Milwaukee, Wisconsin) |
| INVENTOR(S) | Andrzej Jesmanowicz (Wauwatosa, Wisconsin) |
| ABSTRACT | A magnetic resonance imaging (MRI) system includes a transmitter that produces an RF excitation pulse that is applied to a subject positioned in the MRI system to induce emission of at least one of an NMR signal and an ESR signal therefrom, and that produces a reference signal indicative of the phase of the RF excitation pulse. A first analog-to-digital converter has an input for receiving the reference signal that is synchronous with the RF excitation pulse. One or more additional analog-to-digital converters/processors have inputs for receiving the at least one of NMR signals and ESR signals produced by a subject placed in the MRI system and produce one or more complex digital signals therefrom. A normalizer is connected to receive and normalize the digital reference signal and a mixer is connected to receive the normalized digital reference signal and the digital signal. Accordingly, the mixer is operable to multiply the normalized complex digital reference signal with the complex digital signal. |
| FILED | Friday, March 23, 2007 |
| APPL NO | 11/690193 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/173 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807619 | Bertozzi et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Carolyn R. Bertozzi (Berkeley, California); Nicholas J. Agard (Berkeley, California); Jennifer A. Prescher (Berkeley, California); Jeremy Michael Baskin (Berkeley, California) |
| ABSTRACT | The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids). |
| FILED | Monday, October 31, 2005 |
| APPL NO | 11/264463 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807620 | Lustbader |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Joyce Lustbader (Tenafly, New Jersey) |
| ABSTRACT | This invention provides FSH analogues having increased serum half-life relative to FSH. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject. |
| FILED | Friday, July 21, 2006 |
| APPL NO | 11/490825 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807630 | Dang et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Thao P. Dang (Nashville, Tennessee); David P. Carbone (Franklin, Tennessee); Ray Mernaugh (Franklin, Tennessee) |
| ABSTRACT | The present invention involves the use of peptides from Notch3, and antibodies that recognize epitopes represented by those peptides, as anti-cancer agents. Methods of combination therapy using standard anti-cancer protocols in conjunction with Notch3 peptides and antibodies also are provided. |
| FILED | Thursday, September 11, 2008 |
| APPL NO | 12/208875 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807640 | Fogelman et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); The UAB Research Foundation (Birmingham, Alabama) |
| INVENTOR(S) | Alan M. Fogelman (Beverly Hills, California); Gattadahalli M. Anantharamaiah (Birmingham, Alabama); Mohamad Navab (Los Angeles, California) |
| ABSTRACT | This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are class A amphipathic helical peptides. They are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling of pre-beta high density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention also provides a method of tracking a peptide in a mammal. In addition, the peptides inhibit osteoporosis. When administered with a statin, the peptides enhance the activity of the statin permitting the statin to be used at significantly lower dosages and/or cause the statins to be significantly more anti-inflammatory at any given dose. |
| FILED | Wednesday, March 21, 2007 |
| APPL NO | 11/689037 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/12 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807645 | Akassoglou |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Katerina Akassoglou (San Francisco, California) |
| ABSTRACT | The invention herein related to methods and compositions for treating nervous system disorders. The methods comprise peptides that bind to receptors important in disease progression, thus attenuating the disease. |
| FILED | Monday, September 25, 2006 |
| APPL NO | 12/067792 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/13 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807646 | Kerr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | William G. Kerr (Tampa, Florida); Caroline Desponts (Tampa, Florida); Lia Elena Perez (Tampa, Florida) |
| ABSTRACT | A method of increasing megakaryocytes and platelet numbers in a patient comprising the step of inhibiting SHIP expression, including SHIP's enzymatic activity and signaling functions, whereby normal blood clotting is induced. |
| FILED | Monday, November 22, 2004 |
| APPL NO | 10/904667 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/44 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807651 | Huang et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Li-Yen Mae Huang (Galveston, Texas); Yanping Gu (League City, Texas); Ya Xu (League City, Texas) |
| ABSTRACT | Disclosed are methods for treating pain in a subject. The method includes upregulating expression of opioid receptors in the subject's dorsal root ganglion neurons. Also disclosed are methods of treating neuropathic and/or chronic pain in a subject. The method includes upregulating expression of μ-opioid receptors in the subject's large dorsal root ganglion neurons. |
| FILED | Friday, December 14, 2007 |
| APPL NO | 12/002307 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/44 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807662 | Turkson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | James Turkson (Orlando, Florida); Richard Jove (Glendora, California); Said M. Sebti (Tampa, Florida) |
| ABSTRACT | The invention disclosed herein provides methods for diagnosing and treating diseases and/or conditions associated with dysregulated Stat3-mediated activity. |
| FILED | Friday, December 23, 2005 |
| APPL NO | 11/317516 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/183 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807704 | Thomas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Chemocentryx, Inc. (Mountain View, California) |
| INVENTOR(S) | William D. Thomas (San Jose, California); Manmohan Reddy Leleti (Sunnyvale, California); Andrew M. K. Pennell (San Francisco, California) |
| ABSTRACT | The present invention is directed to novel compounds and pharmaceutical compositions that inhibit the binding of the SDF-1 chemokine to the chemokine receptor CXCR4 and/or the binding of the SDF-1 or I-TAC chemokines to the chemokine receptor CCXCKR2 (CXCR7). These compounds are useful in preventing tumor cell proliferation, tumor formation, metastasis, inflammatory diseases, treatment of HIV infectivity, treatment of stem cell differentiation and mobilization disorders, and ocular disorders. |
| FILED | Friday, March 30, 2007 |
| APPL NO | 11/731695 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/412 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807705 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Ohio State University Research Foundation (Columbus, Ohio) |
| INVENTOR(S) | Ching-Shih Chen (Upper Arlington, Ohio); Dasheng Wang (Dublin, Ohio); Jing-Ru Weng (Taichung, Taiwan) |
| ABSTRACT | Compounds and methods for treating cancer and inducing apoptosis in unwanted rapidly proliferating cells. The compounds are shown in formula I: wherein X is hydroxyl or amino; Y is carboxyl or sulfonyl; R1, R2, R3, and R4 can be the same or different and are selected from hydrogen, halogen, methoxy, trifluoromethyl, hydroxyl and combinations thereof, R5, R6, and R7 may be the same or different and are selected from hydrogen, chloro, bromo, nitro, phenyl, amino, methoxy, and combinations thereof, and derivatives or metabolites thereof. |
| FILED | Friday, May 09, 2008 |
| APPL NO | 12/118591 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/415 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807713 | Koh et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | John Tze-tzun Koh (West Grove, Pennsylvania); Paula Lynn McGinley (Langhorne, Pennsylvania); Hongmu Pan (Newark, Delaware) |
| ABSTRACT | Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor. |
| FILED | Friday, May 15, 2009 |
| APPL NO | 12/466805 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/522 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807720 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | PanThera Biopharma, LLC (Aiea, Hawaii) |
| INVENTOR(S) | Alan T. Johnson (Kaneohe, Hawaii); Guan-Sheng Jiao (Honolulu, Hawaii) |
| ABSTRACT | Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 3-phenyl-propionic acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax. |
| FILED | Wednesday, January 30, 2008 |
| APPL NO | 12/011888 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/617 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807778 | Backer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | SibTech, Inc. (Brookfield, Connecticut) |
| INVENTOR(S) | Marina V. Backer (Simsbury, Connecticut); Joseph M. Backer (Simsbury, Connecticut) |
| ABSTRACT | The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; and (b) a binding moiety bound to the targeting moiety; the biological conjugate having a covalent bond between the thiol group of SEQ ID NO:2 and a functional group in the binding moiety. The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; and (b) a binding moiety that comprises an adapter protein, the adapter protein having a thiol group; the biological conjugate having a disulfide bond between the thiol group of SEQ ID NO:2 and the thiol group of the adapter protein. The present invention is also directed to biological sequences employed in the above biological conjugates, as well as pharmaceutical preparations and methods using the above biological conjugates. |
| FILED | Friday, March 14, 2008 |
| APPL NO | 12/075811 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807783 | Dixit et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Vishva M. Dixit (Ann Arbor, Michigan); Karen O'Rourke (Ann Arbor, Michigan) |
| ABSTRACT | This invention provides a novel protein designated FADD, FADD fragments, and anti-FADD antibodies which are useful to modulate Fas-associated cellular functions such as apoptosis. Also provided are nucleic acid molecules coding for these proteins and antibodies as well as process for making these compositions. Further provided are diagnostic and therapeutic methods for these compositions. |
| FILED | Thursday, May 18, 1995 |
| APPL NO | 08/443982 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/350 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807784 | Fu |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Yang-Xin Fu (Chicago, Illinois) |
| ABSTRACT | Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and reduced metastasis using mutant LIGHT are disclosed. |
| FILED | Thursday, June 10, 2004 |
| APPL NO | 10/865623 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/350 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807787 | Ting et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Kang Ting (Beverly Hills, California); Shunichi Kuroda (Osaka, Japan); Ben Wu (Los Angeles, California) |
| ABSTRACT | The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides. |
| FILED | Monday, March 09, 2009 |
| APPL NO | 12/400714 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/350 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807805 | Kawakami et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Yutaka Kawakami (Kanagawa, Japan); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention also provides immunogenic peptides derived from the MART-1 melanoma antigen and a second melanoma antigen designated gp100. This invention further provides immunogenic peptides derived from the MART-1 melanoma antigen or gp100 antigen which have been modified to enhance their immunogenicity. The proteins and peptides provided can serve as an immunogen or vaccine to prevent or treat melanoma. |
| FILED | Monday, July 02, 2007 |
| APPL NO | 11/772277 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Organic compounds 536/23.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807810 | Rikihisa et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Ohio State University Research Foundation (Columbus, Ohio) |
| INVENTOR(S) | Yasuko Rikihisa (Worthington, Ohio); Ning Zhi (Columbus, Ohio); Norio Ohashi (Columbus, Ohio) |
| ABSTRACT | The present invention relates to diagnostic tools for serodiagnosing HGE. The diagnostic tools are structurally related proteins, the “Group 44 proteins”, and to antibodies to such proteins. the Group 44 proteins comprise a single central hypervariable region of approximately 94 amino acid residues, a first conserved region and a second conserved region which flank the central hypervariable region. The hypervariable region of each Group 44 protein has a higher hydrophilicity, a higher antigenic index, and a higher surface probability than either the first conserved region or the second conserved region of the respective protein. The hypervariable region is basic and has an isoelectric point, i.e., a pI, of from about 7.1 to about 9.2 and a molecular mass, i.e., an Mr, of from about 8.5 kDa to about 11 kDa. The Group 44 proteins comprise the P44 protein, the P44-2 protein, the P44-12 protein, the P44-15 protein, the P44-18 protein, and the P44-19 protein and variants of such proteins. The present invention also provides isolated polynucleotides or nucleic acids, referred to collectively hereinafter as the “Group 44 polynucleotides”, which encode the Group 44 proteins and fragments thereof. The present invention provides synthetic oligopeptides of 14-16 amino acids in length. Each of the oligopeptides comprise a sequence which is specific to one Group 44 protein. The present invention also relates to antibodies which are immunospecific for and bind to members of the P44 family of proteinss. The present invention also relates to kits containing reagents for diagnosing HGE. |
| FILED | Monday, August 19, 2002 |
| APPL NO | 10/223598 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Organic compounds 536/23.700 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807842 | Myers et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Andrew G. Myers (Boston, Massachusetts); Mark G. Charest (Somerville, Massachusetts); Christian D. Lerner (Cambridge, Massachusetts); Jason D. Brubaker (Cheshire, Connecticut); Dionicio R. Siegel (New York, New York) |
| ABSTRACT | The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals. |
| FILED | Friday, May 20, 2005 |
| APPL NO | 11/133789 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Organic compounds 548/241 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807875 | Covert et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| INVENTOR(S) | Sarah F. Covert (Athens, Georgia); Terri A. Long (Durham, North Carolina); Gregory W. Schmidt (Bishop, Georgia) |
| ABSTRACT | Transformed plants and/or plant cells having increased tolerance to high light, drought, water-deficit, and/or other stress-inducing conditions are provided. Plants and plant cells expressing or over-expressing an exogenous nucleic acid encoding a polypeptide involved in a CET pathway, including but not limited to, a PGR5 polypeptide, and methods of making the transformed plants and plant cells are also provided. |
| FILED | Tuesday, August 22, 2006 |
| APPL NO | 11/507766 |
| ART UNIT | 1638 — Organic Chemistry |
| CURRENT CPC | Multicellular living organisms and unmodified parts thereof and related processes 8/289 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808921 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Research Foundation of State University of New York (Amherst, New York) |
| INVENTOR(S) | Aidong Zhang (Getzville, New York); Murali Ramanathan (Amherst, New York); Woo-Chang Hwang (Tonawanda, New York); Young-Rae Cho (Williamsville, New York) |
| ABSTRACT | A method for identifying a bridge node in a network using a processor and memory unit in a specially programmed special purpose-purpose computer including the steps of, for each node in a plurality of nodes in the network: determining a global metric proportional to total traffic flow in the network and through the node; determining a local metric proportional to traffic flow between the node and each second node in the network connected to the node and traffic flow between each second node and each third node in the network connected to a second node; determining a second local metric proportional to the respective traffic flows between each node and each second node; and calculating a respective combination of the global metric and the first and second local metrics; and selecting, a bridge node from among the plurality of nodes based on the respective combinations. |
| FILED | Friday, May 18, 2007 |
| APPL NO | 11/804700 |
| ART UNIT | 2467 — Multiplex and VoIP |
| CURRENT CPC | Multiplex communications 370/252 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809177 | Yoshida et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Hiroyuki Yoshida (Watertown, Massachusetts); Janne Näppi (Boston, Massachusetts); Michael E. Zalis (Newtonville, Massachusetts); Wenli Cai (Dorchester, Massachusetts) |
| ABSTRACT | A lumen tracking method and system automatically extracts a colon from CT image data by locating landmarks in the image data, based on known anatomic features or other predictable features. If the colon is segmented, the method and system may use the landmarks to evaluate candidate segments for inclusion in the extracted colon. |
| FILED | Thursday, November 30, 2006 |
| APPL NO | 11/607623 |
| ART UNIT | 2624 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/128 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809424 | Cunningham et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Charles H. Cunningham (San Francisco, California); Steven M. Conolly (Palo Alto, California) |
| ABSTRACT | Off-resonance imaging uses two complementary contrast agents with the first agent (iron-oxide) particles transfected into cells which provide localized signals. The second agent is detected from a change in the off-resonance signal when present in the cells labeled by the first agent. |
| FILED | Thursday, November 10, 2005 |
| APPL NO | 11/271593 |
| ART UNIT | 3737 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Surgery 6/411 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809427 | Winters et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | David W. Winters (Madison, Wisconsin); Barry D. Van Veen (McFarland, Wisconsin); Susan C. Hagness (Madison, Wisconsin) |
| ABSTRACT | A system and a method are provided for estimating the average dielectric properties of a plurality of regions in space. The application of this technique is illustrated for determining the average properties of breast tissue. The knowledge of average properties is important when UWB microwave radar signal processing algorithms are used for tumor detection and localization. The method is an extension of a time-domain inverse scattering algorithm based on the finite-difference time-domain method. A hybrid conjugate gradient optimization is used to minimize a cost function defined between a measured and a calculated total electromagnetic field at a series of antennas. The output of the method is an average set of electromagnetic material parameters that describe specific regions of interest in either a non-dispersive heterogeneous medium or a dispersive heterogeneous medium. |
| FILED | Friday, February 11, 2005 |
| APPL NO | 11/056342 |
| ART UNIT | 3737 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Surgery 6/430 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 07805972 | Prevey, III |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Surface Technology Holdings Ltd. (Cincinnati, Ohio) |
| INVENTOR(S) | Paul S. Prevey, III (Cincinnati, Ohio) |
| ABSTRACT | A method and an apparatus for performing the method of inducing compressive residual stress in blading members integrally formed with a rotor. The method includes using a caliper-type burnishing tool such that the caliper arms of the tool are contoured and oriented for placing the burnishing elements on opposite sides of the blading member to be treated. The blading member is burnished to introduce a pre-determined pattern of residual compressive stresses in a selected area of the blade. |
| FILED | Thursday, October 12, 2006 |
| APPL NO | 11/546970 |
| ART UNIT | 3725 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Metal deforming 072/407 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07806001 | Shaw |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Orbital Research Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Greg S. Shaw (University Heights, Ohio) |
| ABSTRACT | The present invention relates to a pressure sensor comprising multiple flexible diaphragms to which are affixed, within which are embedded, or which themselves constitute part of transducer elements that are connected together electrically, providing greater sensitivity and allowing the diaphragms to be made smaller, thereby increasing burst pressure to operating pressure ratio. This multi-diaphragm pressure sensor can therefore be used to accurately measure small changes in dynamic pressure in a fluid of overall high static pressure, for example, in a flow inventory control system as may be used in a fire suppression system, or for control of nuclear reactor systems. |
| FILED | Thursday, June 05, 2008 |
| APPL NO | 12/156917 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/715 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07806166 | Tilton et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Parker-Hannifin Corporation (Cleveland, Ohio) |
| INVENTOR(S) | Charles L. Tilton (Colton, Washington); William J. Beasley (Moscow, Idaho); Douglas W. Miller (Moscow, Idaho); Randall T. Palmer (Liberty Lake, Washington) |
| ABSTRACT | An insulated spray cooling system for extreme environments for providing a desired enclosed environment for electronic devices regardless of external environmental conditions. The insulated spray cooling system for extreme environments includes an insulated enclosure that isolates the electronic devices being thermally managed from the external environment and a thermal management unit within the enclosure for thermally managing electronic devices. |
| FILED | Thursday, December 15, 2005 |
| APPL NO | 11/303864 |
| ART UNIT | 3744 — Printing/Measuring and Testing |
| CURRENT CPC | Heat exchange 165/58 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07806370 | Beidleman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Composite Technology Development, Inc. (Lafayette, Colorado) |
| INVENTOR(S) | Neal Beidleman (Aspen, Colorado); Gregg Freebury (Lafayette, Colorado); Will Francis (Boulder, Colorado); Mark Lake (Erie, Colorado); Rory Barrett (Erie, Colorado); Philip N. Keller (Longmont, Colorado); Robert Taylor (Superior, Colorado) |
| ABSTRACT | A deployable structure is disclosed. The deployable structure may include one or more slit-tube longerons; and one or more flat sheets coupled with the one or more slit-tube longerons. The one or more slit-tube longerons and the one or more flat sheets may be stowed by rolling the one or more slit-tube longerons and the one or more flat sheets together into a roll. In one embodiment, at least a portion of the one or more slit-tube longerons may be exposed when stowed. In another embodiment, the one or more slit-tube longerons may be manufactured from a shape memory material. These slit-tube longerons unroll into to a straight configuration when exposed to heat. |
| FILED | Monday, April 02, 2007 |
| APPL NO | 11/695163 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeronautics and astronautics 244/172.700 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07806586 | Melamud et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Renata Melamud (Menlo Park, California); Bongsang Kim (Mountain View, California); Matt Hopcroft (San Francisco, California); Saurabh Chandorkar (Stanford, California); Manu Agarwal (Stanford, California); Thomas W. Kenny (San Carlos, California) |
| ABSTRACT | Mechanical transducers such as pressure sensors, resonators or other frequency-reference devices are implemented under conditions characterized by different temperatures. According to an example embodiment of the present invention, a combination of materials is implemented for mechanical transducer applications to mitigate temperature-related changes. In one application, a material property mismatch is used to facilitate single-anchor transducer applications, such as for resonators. Another application is directed to a Silicon-Silicon dioxide combination of materials. |
| FILED | Friday, June 02, 2006 |
| APPL NO | 11/446568 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Thermal measuring and testing 374/117 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07806596 | Shatz et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Windsor Locks, Connecticut) |
| INVENTOR(S) | Mark N. Shatz (San Diego, California); Eric J. Alexander (San Diego, California); Gordon F. Jewess (San Diego, California); James J. McLaughlin (San Diego, California) |
| ABSTRACT | A rotary bearing system that supports a shaft for rotating machinery in a housing comprises: at least one stationary rotary bearing mounted in the housing for supporting a respective journal of the shaft in a desired axial and radial alignment; at least one slidable rotary bearing, with an outer surface mounted within a respective inner support surface of the housing to form a respective linear bearing such that each slidable bearing may slide axially along the inner support surface of the housing, for supporting another respective journal of the shaft with the desired radial alignment; and at least one layer of a crystalline material that exhibits a high degree of basal cleavage bonded to at least one of the linear bearing surfaces; wherein each layer of crystalline material allows each slidable rotary bearing to slide axially along each respective linear bearing to compensate for differences in the coefficient of expansion of the housing and the shaft so as to prevent the bearing system from binding due to extreme environmental conditions. |
| FILED | Friday, August 31, 2007 |
| APPL NO | 11/897834 |
| ART UNIT | 3656 — Material and Article Handling |
| CURRENT CPC | Bearings 384/493 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807000 | Baker |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | James J. Baker (Waldorf, Maryland) |
| ABSTRACT | A thermobaric explosive composition is provided that includes coated fuel particle, a nitramine, and binder. The coated fuel particles preferably have a magnesium core and an aluminum coating. Upon detonation, the nitramine disperses the coated fuel particles over a blast area during a first overpressure stage. The aluminum coating of the fuel particles has a thickness selected to provide an amount of aluminum that is stoichiometrically less than an amount of ambient-air oxygen available in the blast area for aerobic combustion with the aluminum during the first overpressure stage. Once exposed, the magnesium cores may combust to increase the impulse generated in the first overpressure stage. Also provided are articles of manufacture and related methods. |
| FILED | Monday, October 25, 2004 |
| APPL NO | 10/975122 |
| ART UNIT | 1793 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Explosive and thermic compositions or charges 149/109.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807112 | Denes et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Ferencz S. Denes (Madison, Wisconsin); Sorin O. Manolache (Madison, Wisconsin); Noah Hershkowitz (Madison, Wisconsin) |
| ABSTRACT | An apparatus is utilized for producing colloidal dispersions of nanoparticles of electrically conducting materials. The colloidal dispersions are produced in a dense media plasma reactor comprising at least one static electrode and at least one rotating electrode. The plasma reaction sputters off minute particles of the electrically conducting material from which the electrodes are made. Methods of using the colloidal dispersions thus made are also described. Colloidal dispersions of silver produced in this manner are highly effective for bactericidal purposes. |
| FILED | Friday, September 22, 2006 |
| APPL NO | 11/525773 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing 422/186.40 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807127 | Forohar et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Farhad Forohar (Laplata, Maryland); Craig Whitaker (Annapolis, Maryland); William M. Koppes (Adelphi, Maryland) |
| ABSTRACT | The present invention relates to a carbon nanotube that contains nitrogen based functional groups (such as nitro, nitroso, N-oxide, oxime, hydroxylamine, diazo, azo, and azide) that are covalently attached to lattice carbons of the carbon nanotube, directly or via a chemical linker. The present invention also relates to methods for the preparation of the carbon nanotube from an amino-functionalized carbon nanotube via an amino oxidation reaction. The synthetic methods of the present invention allow the nitrogen based functional groups to be attached selectively to one of two distinct regions of the carbon nanotube, the ends or the sidewall, and thus enable the synthesis of a carbon nanotube having nitrogen based functional groups substantially concentrated on either the ends or the sidewall of the carbon nanotube. |
| FILED | Friday, April 14, 2006 |
| APPL NO | 11/417294 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemistry of inorganic compounds 423/447.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807218 | Parkin |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Stuart Stephen Papworth Parkin (San Jose, California) |
| ABSTRACT | A magnetic tunneling element is constructed from a MgO or Mg—ZnO tunnel barrier and an amorphous magnetic layer in proximity with the tunnel barrier. The amorphous magnetic layer includes Co and at least one additional element selected to make the layer amorphous. Magnetic tunnel junctions formed from the amorphous magnetic layer, the tunnel barrier, and an additional ferromagnetic layer have tunneling magnetoresistance values of up to 200% or more. |
| FILED | Thursday, July 26, 2007 |
| APPL NO | 11/829038 |
| ART UNIT | 1712 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Coating processes 427/128 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807258 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Dahsin Liu (Okemos, Michigan); Peter Schulz (Midland, Michigan) |
| ABSTRACT | A composite structure is provided. In another aspect of the present invention, a composite structure has relative layer-to-layer fiber orientations of between approximately 5° and 15°, inclusive. A further aspect of the present invention employs relative fiber offset angles less than 30° on a curved section. Yet another aspect of the present invention provides a three-dimensionally woven configuration where the first sheet is interwoven or mechanically linked with both the adjacent second layer and the opposite third or deeper layer. |
| FILED | Friday, September 21, 2007 |
| APPL NO | 11/903523 |
| ART UNIT | 1786 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Stock material or miscellaneous articles 428/292.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807358 | Huang |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Curators of the University of Missouri (Columbia, Missouri) |
| INVENTOR(S) | Timothy Hui-Ming Huang (Columbus, Ohio) |
| ABSTRACT | The present invention provides a method of hybridization, differential methylation hybridization (DMH) for high throughput methylation analysis of multiple CpG island loci. DMH utilizes nucleic acid probes prepared from a cell sample to screen numerous CpG dinucleotide rich fragments affixed on a screening array. Positive hybridization signals indicate the presence of methylated sites. Methods of preparing the hybridization probes and screening array are also provided. |
| FILED | Friday, July 28, 2006 |
| APPL NO | 11/496073 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807372 | Mirkin et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Sarah J. Hurst (Evanston, Illinois); Min Su Han (Kyung-Buk, South Korea); Abigail K. R. Lytton-Jean (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are methods of screening sequence selectivity of oligonucleotide-binding molecules using a gold nanoparticle based colorimetric assay. |
| FILED | Wednesday, June 04, 2008 |
| APPL NO | 12/133243 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807373 | Srivastava et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Henry M. Jackson Foundation for the Advancement of Military Medicine (Rockville, Maryland) |
| INVENTOR(S) | Shiv Srivastava (Potomac, Maryland); Judd W. Moul (Bethesda, Maryland); Vasantha Srikantan (Rockville, Maryland); Zhiqiang Zou (Gaithersburg, Maryland) |
| ABSTRACT | A nucleic acid sequence that exhibits prostate-specific expression and over-expression in tumor cells is disclosed. The sequence and fragments thereof are useful for detecting, diagnosing, preventing, and treating prostate cancer and other prostate related diseases. The sequence is also useful for measuring hormone responsiveness of prostate cancer cells. |
| FILED | Wednesday, July 02, 2008 |
| APPL NO | 12/166723 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807383 | Boyer et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Thomas G. Boyer (San Antonio, Texas); Amy M. Trauernicht (Chula Vista, California) |
| ABSTRACT | Provided herein are methods and compositions related to diagnosing and treating hormone resistant cancers. |
| FILED | Thursday, April 17, 2008 |
| APPL NO | 12/104709 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807429 | Branchini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Connecticut College (New London, Connecticut) |
| INVENTOR(S) | Bruce R. Branchini (Old Lyme, Connecticut); Tara L. Southworth (Norwich, Connecticut); Jennifer P. DeAngelis (Whitestone, New York); Aldo Roda (Bologna, Italy); Elisa Michelini (Bologna, Italy) |
| ABSTRACT | The present invention relates to an isolated nucleic acid and polypeptide sequence that encodes for a luciferase of Luciola italica, as well as mutants thereof. The luciferase proteins of the present invention have been found to have extended bioluminescence emission that is red- or blue-shifted, and are useful as a bioluminescent marker or as an additive to selected materials. |
| FILED | Tuesday, February 06, 2007 |
| APPL NO | 11/702819 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/189 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807448 | Glezer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eli N. Glezer (Chevy Chase, Maryland); Bandele Jeffrey-Coker (Darnestown, Maryland); Jeff D. Debad (Gaithersburg, Maryland); Sudeep M. Kumar (Gaithersburg, Maryland); George Sigal (Rockville, Maryland); Gisbert Spieles (Bethesda, Maryland); Michael Tsionsky (Derwood, Maryland); Michael Warnock (Carlsbad, California) |
| ABSTRACT | We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state. |
| FILED | Thursday, December 21, 2006 |
| APPL NO | 11/642970 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/287.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807509 | McBride |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sarnoff Corporation (Princeton, New Jersey) |
| INVENTOR(S) | Sterling Eduardo McBride (Princeton, New Jersey) |
| ABSTRACT | The present invention discloses an anodically bonded vacuum cell structure with a glass substrate including a cavity, and a substrate deposited on the glass substrate, thereby enclosing the cavity to form a bonding interface. The bonding interface having silicon such that the substrate includes a layer of silicon or a secondary substrate with silicon layer bonded onto the secondary substrate. |
| FILED | Monday, October 27, 2008 |
| APPL NO | 12/258495 |
| ART UNIT | 2893 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/118 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807595 | Nguyen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Vinh Q Nguyen (Fairfax, Virginia); Jasbinder S Sanghera (Ashburn, Virginia); Ishwar D Aggarwal (Fairfax Station, Virginia) |
| ABSTRACT | This invention pertains to a chalcogenide glass of low optical loss that can be on the order of 30 dB/km or lower, and to a process for preparing the chalcogenide glass. The process includes the steps of optionally preparing arsenic monochalcogenide precursor or the precursor can be provided beforehand; dynamically distilling the precursor in an open system under vacuum from a hot section to a cold section to purify same; homogenizing the precursor in a closed system so that it is of a uniform color; disposing the distilled or purified precursor and at least one chalcogenide element at a hot section of an open distillation system; dynamically distilling under vacuum in an open system so that the precursor and the at least one chalcogenide element are deposited at a cold section of the open system in a more purified state; homogenizing the precursor and the at least chalcogenide element in a closed system while converting the precursor and the at least one chalcogenide element from crystalline phase to glassy phase. |
| FILED | Thursday, July 31, 2008 |
| APPL NO | 12/183095 |
| ART UNIT | 1793 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Compositions: Ceramic 51/37 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807696 | Al-Abed et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Feinstein Institute for Medical Research (Manhasset, New York) |
| INVENTOR(S) | Yousef Al-Abed (Locust Valley, New York); Kevin J. Tracey (Old Greenwich, Connecticut) |
| ABSTRACT | Compounds of Formula (I), pharmaceutical compositions comprising compounds of Formulae (I a) or (VII) and a method of treating a subject with an inflammatory cytokine-mediated disorder comprising administering to the subject a compound of Formulae (I a) or (VII a). The variables of Formulae (I), (I a), (VII) and (VII a) are described herein. |
| FILED | Thursday, October 07, 2004 |
| APPL NO | 10/574612 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/333 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807705 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Ohio State University Research Foundation (Columbus, Ohio) |
| INVENTOR(S) | Ching-Shih Chen (Upper Arlington, Ohio); Dasheng Wang (Dublin, Ohio); Jing-Ru Weng (Taichung, Taiwan) |
| ABSTRACT | Compounds and methods for treating cancer and inducing apoptosis in unwanted rapidly proliferating cells. The compounds are shown in formula I: wherein X is hydroxyl or amino; Y is carboxyl or sulfonyl; R1, R2, R3, and R4 can be the same or different and are selected from hydrogen, halogen, methoxy, trifluoromethyl, hydroxyl and combinations thereof, R5, R6, and R7 may be the same or different and are selected from hydrogen, chloro, bromo, nitro, phenyl, amino, methoxy, and combinations thereof, and derivatives or metabolites thereof. |
| FILED | Friday, May 09, 2008 |
| APPL NO | 12/118591 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/415 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807758 | Reynolds et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| INVENTOR(S) | John R. Reynolds (Gainesville, Florida); Benjamin Dennis Reeves (Great Falls, Montana) |
| ABSTRACT | A method for preparing a defunctionalized alkylenedioxyheterocycle polymer or copolymer involves providing a polycarboxylic acid derivative functionalized alkylenedioxyheterocycle polymer or copolymer and transforming the polymer or copolymer into a defunctionalized alkylenedioxyheterocycle polymer or copolymer which is polyhydroxy, polythiol, polyamino, or polycarboxylic acid functionalized alkylenedioxyheterocycle polymer or copolymer. The monomers, homopolymers and copolymers for use in the method are new compositions of matter. The polymers containing polycarboxylic acid derivative functionalized alkylenedioxyheterocycle units are soluble polymers which are defunctionalized to yield insoluble polyhydroxy, polythiol, polyamino, or polycarboxylic acid functionalized alkylenedioxyheterocycle polymers. These polymers can be cast as films for use as: hole transport layers in organic light emitting diodes; active electrochrome in electrochromic windows, mirrors and displays; field effect transistors, supercapacitors, batteries, photovoltaic cells, and other electronic components; electronic paper; anti-stat conductors; and transparent conductors. |
| FILED | Thursday, January 25, 2007 |
| APPL NO | 12/158941 |
| ART UNIT | 1796 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Synthetic resins or natural rubbers 525/417 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807852 | Ricks-Laskoski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Holly L. Ricks-Laskoski (Springfield, Virginia); Arthur W. Snow (Alexandria, Virginia) |
| ABSTRACT | Disclosed is a new ionic liquid monomer salt and methods of is synthesis and polymerization. The ionic liquid monomer salt is prepared by mixing equimolar amounts of an amine, such as tris[2-(2-methoxyethoxy)-ethyl]amine and an acid functionalized polymerizable monomer, such as 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), which is stirred at ambient temperature until salt formation is complete. Also disclosed is a new ionic liquid polymer salts and method for making the same. The synthesis of AMPS-ammonium salt polymer is accomplished by adding 2,2′-azobisisobutyronitrile (AIBN) to the ionic liquid monomer salt and heating the homogeneous melt at 70° C. for 18 hr. |
| FILED | Friday, August 17, 2007 |
| APPL NO | 11/894639 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Organic compounds 562/114 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807917 | Atanackovic |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Translucent, Inc. (Palo Alto, California) |
| INVENTOR(S) | Petar B. Atanackovic (Palo Alto, California) |
| ABSTRACT | New thermoelectric materials and devices are disclosed for application to high efficiency thermoelectric power generation. New functional materials based on oxides, rare-earth-oxides, rare-earth-nitrides, rare-earth phosphides, copper-rare-earth oxides, silicon-rare-earth-oxides, germanium-rare-earth-oxides and bismuth rare-earth-oxides are disclosed. Addition of nitrogen and phosphorus are disclosed to optimize the oxide material properties for thermoelectric conversion efficiency. New devices based on bulk and multilayer thermoelectric materials are described. New devices based on bulk and multilayer thermoelectric materials using combinations of at least one of thermoelectric and pyroelectric and ferroelectric materials are described. Thermoelectric devices based on vertical pillar and planar architectures are disclosed. The advantage of the planar thermoelectric effect allows utility for large area applications and is scalable for large scale power generation plants. |
| FILED | Thursday, July 26, 2007 |
| APPL NO | 11/828964 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Batteries: Thermoelectric and photoelectric 136/236.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807921 | Fetzer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Christopher M. Fetzer (Saugus, California); Richard R. King (Thousand Oaks, California); Peter C. Colter (Canyon Country, California) |
| ABSTRACT | A multijunction solar cell includes a first photoactive subcell layer having a first-subcell lattice parameter and a composition including (a) at least one Group III element, at least one Group V element other than (nitrogen, phosphorus), and (nitrogen, phosphorus), or (b) a material selected from the group including GaInAsBi, GaInAsSb, GaInAsP, ZnGeAs2, or BGaInAs. The multijunction solar cell also has a substrate having a substrate lattice parameter different from the first-subcell lattice parameter, and a composition-graded buffer layer between the first photoactive subcell layer and the substrate and having a buffer-layer lattice parameter graded between the first-subcell lattice parameter and the substrate lattice parameter. The substrate may be a second photoactive subcell layer having a second-subcell lattice parameter different from the first-subcell lattice parameter and sensitive to a second-photoactive-subcell-layer wavelength, and the buffer layer is transparent to the second-photoactive-subcell-layer wavelength. |
| FILED | Tuesday, June 15, 2004 |
| APPL NO | 10/868079 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Batteries: Thermoelectric and photoelectric 136/262 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807930 | Hansen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Peder Meyer Hansen (San Diego, California); Wendy Marie Massey (La Jolla, California) |
| ABSTRACT | A high-voltage (HV) bushing that comprises first and second sections, at least two internal grading elements, and at least two external grading elements. The first and second sections each have a HV end and a grounded end. The exterior of the first section is configured to be exposed to open air. One internal grading element is mounted to the HV end of the first section and another internal grading element is mounted to the grounded end of the first section. One of the external grading elements is mounted to the HV end of the first section and another external grading element is coupled to the grounded end of the first section. The internal grading elements and the external grading elements are each configured to moderate an electric field along the inner and outer surfaces of the HV bushing near the HV end and the grounded end of the first section. |
| FILED | Friday, November 30, 2007 |
| APPL NO | 11/948417 |
| ART UNIT | 2831 — Electrical Circuits and Systems |
| CURRENT CPC | Electricity: Conductors and insulators 174/142 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808016 | Brar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Teledyne Licensing, LLC (Thousand Oaks, California) |
| INVENTOR(S) | Berinder Brar (Newbury Park, California); Joshua I. Bergman (Thousand Oaks, California); Amal Ikhlassi (Thousand Oaks, California); Gabor Nagy (Thousand Oaks, California); Gerard J. Sullivan (Newbury Park, California) |
| ABSTRACT | A transistor heterogeneously integrating a power amplifier or switch with a low-noise amplifier having a substrate wafer selected from a group consisting of Gallium Arsenide (GaAs), Indium Phosphate (InP) and Gallium Antimonide (GaSb), the substrate wafer having a first end and a second end, a conducting layer above the first end of the substrate wafer, an isolation implant providing lateral isolation in the conducting layer, a first active layer deposited above the conducting layer and configured for the low-noise amplifier, and a buffer layer deposited above the conducting layer and configured for the low-noise amplifier. |
| FILED | Thursday, September 14, 2006 |
| APPL NO | 11/521011 |
| ART UNIT | 2815 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/194 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808080 | Evans et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Dean R. Evans (Beavercreek, Ohio); Gary Cook (Beavercreek, Ohio) |
| ABSTRACT | The present invention provides a photorefractive potassium niobate (KNbO3 ) crystal including a first impurity added substitutionally to the niobium (Nb) site and a second impurity added substitutionally to the potassium (K) site, wherein the first and second impurities are different. There is also provided a method of making the codoped potassium niobate crystal (KNbO3 ) of the present invention wherein the method includes adding at least one of the impurities to a melt composition during crystal growth, adding at least one of the impurities into an existing crystal using thermal diffusion, and/or adding at least one of impurities into an existing crystal using electrically assisted diffusion. |
| FILED | Monday, March 19, 2007 |
| APPL NO | 11/687914 |
| ART UNIT | 2826 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/607 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808158 | Deeds et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Michael Deeds (Port Tobacco, Maryland); Veronica Valeriano (Alexandria, Virginia); Gerald Laib (Olney, Maryland); John Hendershot (Dunkirk, Maryland); David Olson (Chesapeake Beach, Maryland) |
| ABSTRACT | An electrical generator includes a fluid-flow driven impeller including at least one impact arm; and at least one cantilevered beam disposed such that the impact arm strikes the cantilevered beam as the impeller rotates. The cantilevered beam at least partially includes a piezoelectric film. |
| FILED | Thursday, September 27, 2007 |
| APPL NO | 11/973993 |
| ART UNIT | 2837 — Electrical Circuits and Systems |
| CURRENT CPC | Electrical generator or motor structure 310/339 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808315 | Goodman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Joel I. Goodman (Chelmsford, Massachusetts); Benjamin A. Miller (Allston, Massachusetts); Matthew A. Herman (Boston, Massachusetts) |
| ABSTRACT | A method or corresponding apparatus relates to a mathematical approach to efficiently search for and localize regions in a multi-dimensional signal space to enable inversion of power amplifier nonlinearities with a significant reduction in computational complexity and an efficient hardware implementation. To linearize a wideband power amplifier, an example embodiment of the present invention may represent a response of the wideband power amplifier using coefficients in a cube coefficient subspace, and search over the full multi-dimensional subspace according to an optimization criterion in order to identify a vector of cube coefficient subspace coefficients. The vector of coefficient subspace coefficients may be used to linearize the wide-band power amplifier. |
| FILED | Friday, May 23, 2008 |
| APPL NO | 12/154669 |
| ART UNIT | 2817 — Semiconductors/Memory |
| CURRENT CPC | Amplifiers 330/149 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808359 | Rao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dantam K. Rao (Schenectady, New York) |
| ABSTRACT | A high power, high frequency toroidal inductor is broken into four quadrant cores and uses bare rectangular conductors to form coils. One coil is wound centrally around each quadrant. The coils positioned centrally on the quadrants minimize the effect of damaging fringe flux and leakage flux. The coil inner winding ends are bent perpendicular to the coils to form tangential leads with one coil inner tangential lead joined to an adjacent outer coil radial lead by jumpers that span adjacent coils. |
| FILED | Friday, October 21, 2005 |
| APPL NO | 11/254758 |
| ART UNIT | 2832 — Semiconductors/Memory |
| CURRENT CPC | Inductor devices 336/229 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808426 | Smith, Jr. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Jerry R. Smith, Jr. (Alexandria, Virginia) |
| ABSTRACT | A broadband radar arrangement having a radar transmitter and a radar receiver mounted above a targeted water surface to monitor and determine a sea state of the targeted water surface. Spectrally spaced signals are transmitted by the transmitter and received by the receiver, via a direct path and via a forward scattered path off the targeted water surface. An interference pattern of interfering direct path signals and forward scattered signals is used to determine an instantaneous height of the water surface and also to determine the sea state of the targeted water surface. |
| FILED | Monday, May 05, 2008 |
| APPL NO | 12/152124 |
| ART UNIT | 3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Communications: Directive radio wave systems and devices 342/123 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808528 | Massie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Nova Research, Inc. (Solvang, California) |
| INVENTOR(S) | Mark Alan Massie (Santa Ynez, California); Jon Paul Curzan (Arroyo Grande, California); Christopher Robert Baxter (Santa Barbara, California); Ralph Roch Etienne-Cummings (Washington, District of Columbia) |
| ABSTRACT | A variable acuity imager incorporates an array of detection elements for light energy, in the visible, infrared, ultraviolet, or light energy in another region of the electromagnetic spectrum with a means to change the spatial configuration of the array to include “superpixels” by combining energy detected by adjacent elements, thus permitting any number of high-resolution “foveal” regions to be placed within the confines of the focal plane array and moved around at the frame rate of the imaging device. Detectors to measure the pitch, yaw and roll angle rates of background imagery using velocity-sensing circuitry are employed for variation of the foveal regions to accommodate motion of the array. |
| FILED | Monday, July 21, 2008 |
| APPL NO | 12/177048 |
| ART UNIT | 2622 — Selective Visual Display Systems |
| CURRENT CPC | Television 348/208.140 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808636 | Schulkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Brian Schulkin (Troy, New York); Xi-Cheng Zhang (Troy, New York); Thomas Tongue (Niskayuna, New York); Jingzhou Xu (Ann Arbor, Michigan); Jian Chen (Troy, New York) |
| ABSTRACT | Methods and apparatus for detecting variations in electromagnetic fields, in particular, terahertz (THz) electromagnetic fields, are provided. The methods and apparatus employ polarization detection devices and controllers to maintain or vary the polarization of modulated signals as desired. The methods and apparatus are provided to characterize electromagnetic fields by directing the electromagnetic field and a probe beam upon an electro-crystal and detecting the modulation of the resulting probe beam. Detection of the modulation of the probe beam is practiced by detecting and comparing the polarization components of the modulated probe beam. Aspects of the invention may be used to analyze or detect explosives, explosive related compounds, and pharmaceuticals, among other substances. A compact apparatus, modular optical devices for use with the apparatus, sample holders, and radiation source mounts are also disclosed. |
| FILED | Friday, January 11, 2008 |
| APPL NO | 12/013167 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/365 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808716 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Northeastern University (Boston, Massachusetts) |
| INVENTOR(S) | Wentao T. Lu (Malden, Massachusetts); Srinivas Sridhar (Newton, Massachusetts); Plarenta Vodo (Malden, Massachusetts); Patanjali Parimi (Belmont, Massachusetts); Yongjian Huang (Malden, Massachusetts) |
| ABSTRACT | Negative refraction in photonic crystals and diffraction grating is used to design plano-concave lenses to focus plane waves. Microwave experiments are carried out to demonstrate negative refraction and the performance of these lenses. Demonstration of negative refraction of visible light is also performed for the grism. These lenses can be used in optical circuits, astronomical applications, etc. |
| FILED | Tuesday, May 16, 2006 |
| APPL NO | 11/920613 |
| ART UNIT | 2873 — Optics |
| CURRENT CPC | Optical: Systems and elements 359/642 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808722 | Tonucci |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Ronald J Tonucci (Waldorf, Maryland) |
| ABSTRACT | A lens system with a lens formed of a material having a negative index of refraction in an operational frequency range, a first surface of the material having a convex hyperbolic curvature, and a second surface of the material having a concave circular curvature. A lens system can include two of these lenses, arranged with the concave circular surfaces facing each other. Far field radiation arriving at the hyperbolic surface of the the first lens is refracted by the lens material toward the circular surface, out of the first lens in a direction parallel to the original radiation direction, and into the circular surface of the second lens, where it is refracted toward the hyperbolic surface of the second lens, and exits the second lens in a direction parallel to the original direction. The lens material can have a tunable or fixed negative refractive index and/or resonant frequency. |
| FILED | Friday, September 26, 2008 |
| APPL NO | 12/239313 |
| ART UNIT | 2873 — Optics |
| CURRENT CPC | Optical: Systems and elements 359/717 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808926 | Harchol-Balter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Mor Harchol-Balter (Pittsburgh, Pennsylvania); F. Thomson Leighton (Newtonville, Massachusetts); Daniel Lewin (Cambridge, Massachusetts) |
| ABSTRACT | In distributed networks of cooperating nodes, it is useful to perform resource discovery in a manner that is efficient but that also minimizes communication complexity. A system and method in which nodes in a network efficiently are provided with information about the presence of, and other information about, other nodes in the network provides tangible benefits. In general, in one aspect, a system and method according to the invention features a distributed method for communicating information among a plurality of nodes. The method includes choosing, by a first node, one second node from information about nodes that the first node is aware of. The method further includes communicating from the first node to the second node information about the first node and nodes that the first node is aware of. The method further includes adding or merging, by the second node, the information about the first node and nodes that the first node is aware of with information about nodes that the second node is aware of. The method further includes each of the plurality of cooperating nodes repeating these steps. |
| FILED | Tuesday, October 02, 2007 |
| APPL NO | 11/866180 |
| ART UNIT | 2471 — Multiplex and VoIP |
| CURRENT CPC | Multiplex communications 370/254 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809030 | Shaw et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Leslie Brandon Shaw (Woodbridge, Virginia); Jasbinder S. Sanghera (Ashburn, Virginia); Ishwar D. Aggarwal (Fairfax Station, Virginia) |
| ABSTRACT | A wavelength converter comprising an arsenic sulfide (As—S) chalcogenide glass fiber coupled to an optical parametric oscillator (OPO) crystal and a laser system using an OPO crystal coupled to an As—S fiber are provided. The OPO receives pump laser radiation from a pump laser and emits laser radiation at a wavelength that is longer than the pump laser radiation. The laser radiation that is emitted from the OPO is input into the As—S fiber, which in turn converts the input wavelength from the OPO to a desired wavelength, for example, a wavelength beyond about 4.4 μm. In an exemplary embodiment, the OPO comprises a periodically poled lithium niobate (PPLN) crystal. The As—S fiber can include any suitable type of optical fiber, such as a conventional core clad fiber, a photonic crystal fiber, or a microstructured fiber. |
| FILED | Tuesday, March 24, 2009 |
| APPL NO | 12/409799 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Coherent light generators 372/22 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809115 | Allen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Raymond J Allen (Vienna, Virginia); Gerald Cooperstein (Rockville, Maryland); Joseph W Schumer (Falls Church, Virginia) |
| ABSTRACT | A flash radiography diode includes a cathode and an anode. The cathode includes a frustum member with a bore extending through the frustum member. The anode is a tapered anode made of an electrically conductive material and oriented toward the cathode. The anode and the cathode are housed in a chamber with a gap between the anode and the cathode. The cathode is configured to emit electrons to the tapered anode, which electrons strike the anode and create an anode plasma. The anode plasma creates X rays which propagate from the anode. |
| FILED | Tuesday, September 09, 2008 |
| APPL NO | 12/207039 |
| ART UNIT | 2882 — Optics |
| CURRENT CPC | X-ray or gamma ray systems or devices 378/136 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809230 | Christopher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | kSARIA Corporation (Lawrence, Massachusetts) |
| INVENTOR(S) | Anthony J. Christopher (Andover, Massachusetts); John C. Briggs (Lexington, Massachusetts); Michael Mucci (Upton, Massachusetts) |
| ABSTRACT | An apparatus is provided for shaping an end of an optical fiber. The apparatus may include a frame and a clamp constructed to hold the optical fiber in a fixed location relative to the frame. The apparatus may further include a tip shaper supported by the frame and movable in a first direction toward and away from the clamp, and moveable in a second direction that lies in a plane transverse to the first direction to shape the end of the optical fiber when the tip shaper is placed in contact with the optical fiber. The apparatus may include an abrasive substrate which abrades the end of the fiber. |
| FILED | Tuesday, September 25, 2007 |
| APPL NO | 11/904015 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical waveguides 385/134 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809267 | Menendez |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Telcordia Technologies, Inc. (Piscataway, New Jersey) |
| INVENTOR(S) | Ronald Charles Menendez (Chatham, New Jersey) |
| ABSTRACT | The present invention is directed to a coherent gated receiver. The receiver includes a decoder operable to receive an optical signal and generate a decoded optical signal, the decoder comprises a demultiplexer operable to spatially distribute the optical signal, a phase mask operable to decode the spatially distributed optical signal, and a multiplexer operable to combine the decoded spatially distributed optical signal. The receiver also includes a laser source operable to provide a pulse signal, a combiner coupled to the laser source and the decoder operable to combine the decoded optical signal and the pulse signal, and a detector operable to detect an output from the combiner. |
| FILED | Thursday, June 01, 2006 |
| APPL NO | 11/444763 |
| ART UNIT | 2613 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Optical communications 398/78 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809428 | Elmaleh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts); IntraMedical Imaging LLC (Los Angeles, California) |
| INVENTOR(S) | David Elmaleh (Boston, Massachusetts); Farhad Daghighian (Los Angeles, California) |
| ABSTRACT | The present invention relates to devices for detection of active atheromatous plaque and/or thin-capped fibro-atheroma (“vulnerable plaque”) using selectively targeted radiolabeled compositions, such as beta-emitting compositions. |
| FILED | Friday, August 09, 2002 |
| APPL NO | 10/215600 |
| ART UNIT | 3768 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Surgery 6/436 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809765 | Evans et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | General Electric Company (Niskayuna, New York) |
| INVENTOR(S) | Scott Charles Evans (Schenectady, New York); Thomas Stephen Markham (Schenectady, New York); Andrew Soliz Torres (Troy, New York) |
| ABSTRACT | The present technique provides for the analysis of a data series to identify sequences of interest within the series. Specifically, in accordance with one embodiment of the present technique, a method is provided comprising generating a data structure that stores characteristics about a plurality of sequences present in a data series. One or more sequences are identified based upon the contents of the data structure. In accordance with other aspects of the invention, more than one heuristic is calculated for each sequence under review. The plurality of heuristics associated with each sequence are evaluated to identify a sequence of interest. |
| FILED | Friday, August 24, 2007 |
| APPL NO | 11/844619 |
| ART UNIT | 2163 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/802 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809880 | Forbis, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | L-3 Communications Integrated Systems L.P. (Greenville, Texas) |
| INVENTOR(S) | William R. Forbis, III (Rockwall, Texas); Patrick H. Horsley (Montgomery, Texas) |
| ABSTRACT | Systems and methods for managing operation of multiple tape drives in a way so that incoming data is spread or distributed across the multiple tape drives and which may be implemented in one example to continuously accept for recording without interruption from one or more data sources, for example, so that the date is distributed across the multiple tape drives in real time and without interruption as it becomes available from one or more given data sources. Two or more tape drives may be further be managed in a manner such that the multiple drives appear to be a single drive when writing data to, or reading data from, the multiple tape drives. |
| FILED | Monday, September 17, 2007 |
| APPL NO | 11/901446 |
| ART UNIT | 2187 — Computer Architecture and I/O |
| CURRENT CPC | Electrical computers and digital processing systems: Memory 711/111 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809941 | Thurman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| INVENTOR(S) | Sally C. Thurman (Cedar Rapids, Iowa); Karl F. Hoech (Cedar Rapids, Iowa); Frank A. Hummer (Cedar Rapids, Iowa) |
| ABSTRACT | A computer-implemented method for generating a hierarchical set of certifiers nodes for a public key infrastructure within an ad-hoc network. The method includes determining at least one potential certifier node that is eligible to become certifier nodes from a set of nodes in an ad-hoc network, creating a new certifier node from the at least one potential certifier node based on a selection criteria, and creating a parent-child relationship with the new certifier node. |
| FILED | Friday, September 09, 2005 |
| APPL NO | 11/222693 |
| ART UNIT | 2431 — Cryptography and Security |
| CURRENT CPC | Electrical computers and digital processing systems: Support 713/158 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809970 | Arimilli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Lakshminarayana B. Arimilli (Austin, Texas); Ravi K. Arimilli (Austin, Texas); Ramakrishnan Rajamony (Austin, Texas) |
| ABSTRACT | A method, computer program product, and system are provided performing a Message Passing Interface (MPI) job. A first processor chip receives a set of arrival signals from a set of processor chips executing tasks of the MPI job in the data processing system. The arrival signals identify when a processor chip executes a synchronization operation for synchronizing the tasks for the MPI job. Responsive to receiving the set of arrival signals from the set of processor chips, the first processor chip identifies a fastest processor chip of the set of processor chips whose arrival signal arrived first. An operation of the fastest processor chip is modified based on the identification of the fastest processor chip. The set of processor chips comprises processor chips that are in one of a same processor book or a different processor book of the data processing system. |
| FILED | Monday, August 27, 2007 |
| APPL NO | 11/845225 |
| ART UNIT | 2115 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Electrical computers and digital processing systems: Support 713/375 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07810000 | Ngo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Hung C. Ngo (Austin, Texas); Gary D. Carpenter (Austin, Texas); Alan J. Drake (Round Rock, Texas); Jente B. Kuang (Austin, Texas) |
| ABSTRACT | An in-circuit timing monitor having a selectable-path ring oscillator circuit provides delay and performance measurements in an actual circuit environment. A test mode signal is applied to a digital circuit to de-select a given functional input signal applied to a functional logic block within the digital circuit and replace it with feedback coupled from an output of the functional logic block, when test mode operation is selected. The signal path from the de-selected input to the output is selected so that the signal path will oscillate, and a characteristic frequency or phase of the output signal is measured to determine the delay. Other inputs to the functional logic block are set to a predetermined set of logic values. The selection may be made at a register preceding the digital inputs or made in the first level of logic of the functional logic block. |
| FILED | Tuesday, November 14, 2006 |
| APPL NO | 11/559436 |
| ART UNIT | 2117 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Error detection/correction and fault detection/recovery 714/724 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US RE41797 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Aerospace Corporation (Los Angeles, California) |
| INVENTOR(S) | Rajendra Kumar (Cerritos, California); Tien M. Nguyen (Yorba Linda, California) |
| ABSTRACT | A polyphase channelizer converts an intermediate frequency wideband signal into a complex signal that is sampled by parallel analog-to-digital converters having a bank of samplers respectively clocked by staggered clocking signals for respective converters for feeding I and Q quadrature samples to a polyphase filter bank of finite impulse response filters driving a fast Fourier transform processor for providing channelized digital signal outputs. The parallel analog-to-digital converters can operate at lower speeds but are parallel connected for effectively operating at required higher speeds. The channelizer channelizes the wideband signal using a polyphase clock for enabling high speed sampling and converting through low speed parallel analog to digital converters. |
| FILED | Friday, December 05, 2008 |
| APPL NO | 12/328871 |
| ART UNIT | 2611 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Pulse or digital communications 375/349 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US RE41801 | Venkatasubramanian |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Nextreme Thermal Solutions, Inc. (Durham, North Carolina) |
| INVENTOR(S) | Rama Venkatasubramanian (Cary, North Carolina) |
| ABSTRACT | A termoelectric thermoelectric device and method for manufacturing the thermoelectric device. The thermoelectric thermoelectric device includes at least one deposited film of a thermoelectric material having opposed first and second major surfaces separated by a thickness of the at least one deposited film with the at least one deposited film being patterned to define a plurality of thermoelements arranged in a matrix pattern having rows of alternating conductivity type, a first header having formed thereon a first interconnecting member with the first header mounted on the first major surface of the deposited film such that the first interconnecting member is connected to one side of the plurality of thermoelements and connects adjacent thermoelements of an opposite conductivity type, and a second header having formed thereon a second interconnecting member with the second heads mounted on the second major surface of the deposited film such that the second interconnecting member is connected to an opposite side of said plurality of thermoelements and connects adjacent thermoelements of an opposite conductivity type. |
| FILED | Tuesday, March 31, 1998 |
| APPL NO | 10/404144 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 07807063 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Giner Electrochemical Systems, LLC (Newton, Massachusetts) |
| INVENTOR(S) | Han Liu (Waltham, Massachusetts); Anthony B. LaConti (Lynnfield, Massachusetts) |
| ABSTRACT | A solid polymer electrolyte composite membrane and method of manufacturing the same. According to one embodiment, the composite membrane comprises a rigid, non-electrically-conducting support, the support preferably being a sheet of polyimide having a thickness of about 7.5 to 15 microns. The support has a plurality of cylindrical pores extending perpendicularly between opposing top and bottom surfaces of the support. The pores, which preferably have a diameter of about 0.1 to 5 microns, are made by plasma etching and preferably are arranged in a defined pattern, for example, with fewer pores located in areas of high membrane stress and more pores located in areas of low membrane stress. The pores are filled with a first solid polymer electrolyte, such as a perfluorosulfonic acid (PFSA) polymer. A second solid polymer electrolyte, which may be the same as or different than the first solid polymer electrolyte, may be deposited over the top and/or bottom of the first solid polymer electrolyte. |
| FILED | Thursday, October 21, 2004 |
| APPL NO | 10/970685 |
| ART UNIT | 1713 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Etching a substrate: Processes 216/39 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807104 | Haas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Jeffrey S. Haas (San Ramon, California); Randall L. Simpson (Livermore, California); Joe H. Satcher (Patterson, California) |
| ABSTRACT | An inspection tester that can be used anywhere as a primary screening tool by non-technical personnel to determine whether a surface contains explosives. It includes a body with a sample pad. First and second explosives detecting reagent holders and dispensers are operatively connected to the body and the sample pad. The first and second explosives detecting reagent holders and dispensers are positioned to deliver the explosives detecting reagents to the sample pad. A is heater operatively connected to the sample pad. |
| FILED | Monday, July 11, 2005 |
| APPL NO | 11/179436 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing 422/58 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807112 | Denes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Ferencz S. Denes (Madison, Wisconsin); Sorin O. Manolache (Madison, Wisconsin); Noah Hershkowitz (Madison, Wisconsin) |
| ABSTRACT | An apparatus is utilized for producing colloidal dispersions of nanoparticles of electrically conducting materials. The colloidal dispersions are produced in a dense media plasma reactor comprising at least one static electrode and at least one rotating electrode. The plasma reaction sputters off minute particles of the electrically conducting material from which the electrodes are made. Methods of using the colloidal dispersions thus made are also described. Colloidal dispersions of silver produced in this manner are highly effective for bactericidal purposes. |
| FILED | Friday, September 22, 2006 |
| APPL NO | 11/525773 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing 422/186.40 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807411 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Jiangyun Wang (San Diego, California); Jianming Xie (San Diego, California); Peter G. Schultz (La Jolla, California) |
| ABSTRACT | The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems. |
| FILED | Monday, May 21, 2007 |
| APPL NO | 11/805247 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/69.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807419 | Hennessey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | E. I. du Pont de Nemours and Company (Wilmington, Delaware); Alliance for Sustainable Energy LLC (Golden, Colorado) |
| INVENTOR(S) | Susan M. Hennessey (Avondale, Pennsylvania); Mayis Seapan (Landenberg, Pennsylvania); Richard T. Elander (Evergreen, Colorado); Melvin P. Tucker (Lakewood, Colorado) |
| ABSTRACT | Processes for saccharification of pretreated biomass to obtain high concentrations of fermentable sugars are provided. Specifically, a process was developed that uses a fed batch approach with particle size reduction to provide a high dry weight of biomass content enzymatic saccharification reaction, which produces a high sugars concentration hydrolysate, using a low cost reactor system. |
| FILED | Wednesday, August 22, 2007 |
| APPL NO | 11/843114 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/101 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807434 | Dunn-Coleman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Danisco US Inc. (Palo Alto, California) |
| INVENTOR(S) | Nigel Dunn-Coleman (Los Gatos, California); Frits Goedegebuur (Vlaardingen, Netherlands); Michael Ward (San Francisco, California); Jian Yao (Sunnyvale, California) |
| ABSTRACT | The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding EGVI amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVI, recombinant EGVI proteins and methods for producing the same. |
| FILED | Tuesday, January 10, 2006 |
| APPL NO | 11/329714 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/209 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807606 | Tranter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Troy J. Tranter (Idaho Falls, Idaho); Nicholas R. Mann (Blackfoot, Idaho); Terry A. Todd (Aberdeen, Idaho); Ronald S. Herbst (Idaho Falls, Idaho) |
| ABSTRACT | A method of producing an adsorption medium to remove at least one constituent from a feed stream. The method comprises dissolving and/or suspending at least one metal compound in a solvent to form a metal solution, dissolving polyacrylonitrile into the metal solution to form a PAN-metal solution, and depositing the PAN-metal solution into a quenching bath to produce the adsorption medium. The at least one constituent, such as arsenic, selenium, or antimony, is removed from the feed stream by passing the feed stream through the adsorption medium. An adsorption medium having an increased metal loading and increased capacity for arresting the at least one constituent to be removed is also disclosed. The adsorption medium includes a polyacrylonitrile matrix and at least one metal hydroxide incorporated into the polyacrylonitrile matrix. |
| FILED | Tuesday, August 23, 2005 |
| APPL NO | 11/210577 |
| ART UNIT | 1793 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Catalyst, solid sorbent, or support therefor: Product or process of making 52/439 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807778 | Backer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | SibTech, Inc. (Brookfield, Connecticut) |
| INVENTOR(S) | Marina V. Backer (Simsbury, Connecticut); Joseph M. Backer (Simsbury, Connecticut) |
| ABSTRACT | The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; and (b) a binding moiety bound to the targeting moiety; the biological conjugate having a covalent bond between the thiol group of SEQ ID NO:2 and a functional group in the binding moiety. The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; and (b) a binding moiety that comprises an adapter protein, the adapter protein having a thiol group; the biological conjugate having a disulfide bond between the thiol group of SEQ ID NO:2 and the thiol group of the adapter protein. The present invention is also directed to biological sequences employed in the above biological conjugates, as well as pharmaceutical preparations and methods using the above biological conjugates. |
| FILED | Friday, March 14, 2008 |
| APPL NO | 12/075811 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808129 | Mazumder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Sudip K. Mazumder (Chicago, Illinois); Sanjaya K. Pradhan (Des Plaines, Illinois) |
| ABSTRACT | A power conditioner includes power converters for supplying power to a load, a set of selection switches corresponding to the power converters for selectively connecting the fuel-cell stack to the power converters, and another set of selection switches corresponding to the power converters for selectively connecting the battery to the power converters. The power conveners output combined power that substantially optimally meets a present demand of the load. |
| FILED | Tuesday, October 24, 2006 |
| APPL NO | 12/084021 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Electrical transmission or interconnection systems 37/140 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808182 | New et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sarnoff Corporation (Princton, New Jersey) |
| INVENTOR(S) | David Arthur New (Mercerville, New Jersey); Robert Amantea (Manalapan, New Jersey); Peter James Coyle (Newtown, Pennsylvania) |
| ABSTRACT | The present invention provides an enhanced THz electromagnetic source structure achieving a very high aspect ratio of 500 to 1 of electron beam width to electron beam thickness of the electron beam moving in the direction across the grating structure while maintaining its cross-section. The structure comprises a magnetic circuit providing a unique low magnetic field slot placed in a steel core for the placement of an electron gun, thus allowing the electron beam to be focused without the interaction of a magnetic field while still supporting a high magnetic field in the grating region. Additionally, the structure comprises an electrostatic shield preventing potential difference between the anode voltage and the grounded steel core from affecting the focusing of the electron beam. |
| FILED | Wednesday, August 01, 2007 |
| APPL NO | 11/832193 |
| ART UNIT | 2821 — Electrical Circuits and Systems |
| CURRENT CPC | Electric lamp and discharge devices: Systems 315/5.380 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808635 | Chrisp |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Michael P. Chrisp (Danville, California) |
| ABSTRACT | A wide swath imaging spectrometer utilizing an array of individual spectrometer modules in the telescope focal plane to provide an extended field of view. The spectrometer modules with their individual detectors are arranged so that their slits overlap with motion on the scene providing contiguous spatial coverage. The number of modules can be varied to take full advantage of the field of view available from the telescope. |
| FILED | Wednesday, August 27, 2008 |
| APPL NO | 12/199575 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/326 |
| VIEW PATENT | @ USPTO: Full Text PDF |
07810093 — Parallel-aware, dedicated job co-scheduling within/across symmetric multiprocessing nodes
| US 07810093 | Jones et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Terry R. Jones (Livermore, California); Pythagoras C. Watson (Livermore, California); William Tuel (Kingston, New York); Larry Brenner (Austin, Texas); Patrick Caffrey (Saugerties, New York); Jeffrey Fier (Livermore, California) |
| ABSTRACT | In a parallel computing environment comprising a network of SMP nodes each having at least one processor, a parallel-aware co-scheduling method and system for improving the performance and scalability of a dedicated parallel job having synchronizing collective operations. The method and system uses a global co-scheduler and an operating system kernel dispatcher adapted to coordinate interfering system and daemon activities on a node and across nodes to promote intra-node and inter-node overlap of said interfering system and daemon activities as well as intra-node and inter-node overlap of said synchronizing collective operations. In this manner, the impact of random short-lived interruptions, such as timer-decrement processing and periodic daemon activity, on synchronizing collective operations is minimized on large processor-count SPMD bulk-synchronous programming styles. |
| FILED | Monday, November 15, 2004 |
| APPL NO | 10/989704 |
| ART UNIT | 2195 — Interprocess Communication and Software Development |
| CURRENT CPC | Electrical computers and digital processing systems: Virtual machine task or process management or task management/control 718/102 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 07807348 | Abbott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Nicholas Lawrence Abbott (Madison, Wisconsin); Paul F. Nealey (Madison, Wisconsin) |
| ABSTRACT | A method of imaging phenomena that occurs on a surface of a substrate includes contacting a fluid with a top surface of the substrate, and imaging phenomena that occurs on the top surface of the substrate by observing the substrate through polarized light in the absence of a liquid crystal after the liquid has contacted the top surface of the substrate. The top surface of the substrate has an anisotropic topography, and the wavelength of the polarized light is larger than the anisotropic topography of the top surface of the substrate. A method for determining the presence of an analyte in a sample includes: contacting a sample with a first portion of a top surface of a substrate that binds the analyte, the top surface of the substrate having an anisotropic topography; viewing the substrate through polarized light in the absence of a liquid crystal after it has been contacted with the sample; and determining whether the analyte is present in the sample by ascertaining whether the first portion of the top surface that was contacted with the sample appears different than it did before it was contacted with the sample. The wavelength of the polarized light is larger than the anisotropic topography of the top surface of the substrate. A difference in the appearance of the first portion of the top surface before and after contact with the sample indicates the presence of the analyte in the sample. |
| FILED | Wednesday, March 20, 2002 |
| APPL NO | 10/102540 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807372 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Sarah J. Hurst (Evanston, Illinois); Min Su Han (Kyung-Buk, South Korea); Abigail K. R. Lytton-Jean (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are methods of screening sequence selectivity of oligonucleotide-binding molecules using a gold nanoparticle based colorimetric assay. |
| FILED | Wednesday, June 04, 2008 |
| APPL NO | 12/133243 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807422 | Koffas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Research Foundation of State University of New York (Amherst, New York) |
| INVENTOR(S) | Mattheos Koffas (Williamsville, New York); Effendi Leonard (Buffalo, New York); Yajun Yan (Amherst, New York); Joseph Chemler (Brookfield, Illinois) |
| ABSTRACT | Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phenylpropanoids to various flavonoids. The method comprises the steps of introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes. When specific substrate(s) is/are provided to the transformed cell, the enzymes act on the substrate(s) to produce the desired flavonoids. |
| FILED | Monday, March 03, 2008 |
| APPL NO | 12/074332 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/125 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807429 | Branchini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Connecticut College (New London, Connecticut) |
| INVENTOR(S) | Bruce R. Branchini (Old Lyme, Connecticut); Tara L. Southworth (Norwich, Connecticut); Jennifer P. DeAngelis (Whitestone, New York); Aldo Roda (Bologna, Italy); Elisa Michelini (Bologna, Italy) |
| ABSTRACT | The present invention relates to an isolated nucleic acid and polypeptide sequence that encodes for a luciferase of Luciola italica, as well as mutants thereof. The luciferase proteins of the present invention have been found to have extended bioluminescence emission that is red- or blue-shifted, and are useful as a bioluminescent marker or as an additive to selected materials. |
| FILED | Tuesday, February 06, 2007 |
| APPL NO | 11/702819 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/189 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807842 | Myers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Andrew G. Myers (Boston, Massachusetts); Mark G. Charest (Somerville, Massachusetts); Christian D. Lerner (Cambridge, Massachusetts); Jason D. Brubaker (Cheshire, Connecticut); Dionicio R. Siegel (New York, New York) |
| ABSTRACT | The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals. |
| FILED | Friday, May 20, 2005 |
| APPL NO | 11/133789 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Organic compounds 548/241 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807875 | Covert et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| INVENTOR(S) | Sarah F. Covert (Athens, Georgia); Terri A. Long (Durham, North Carolina); Gregory W. Schmidt (Bishop, Georgia) |
| ABSTRACT | Transformed plants and/or plant cells having increased tolerance to high light, drought, water-deficit, and/or other stress-inducing conditions are provided. Plants and plant cells expressing or over-expressing an exogenous nucleic acid encoding a polypeptide involved in a CET pathway, including but not limited to, a PGR5 polypeptide, and methods of making the transformed plants and plant cells are also provided. |
| FILED | Tuesday, August 22, 2006 |
| APPL NO | 11/507766 |
| ART UNIT | 1638 — Organic Chemistry |
| CURRENT CPC | Multicellular living organisms and unmodified parts thereof and related processes 8/289 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808636 | Schulkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Brian Schulkin (Troy, New York); Xi-Cheng Zhang (Troy, New York); Thomas Tongue (Niskayuna, New York); Jingzhou Xu (Ann Arbor, Michigan); Jian Chen (Troy, New York) |
| ABSTRACT | Methods and apparatus for detecting variations in electromagnetic fields, in particular, terahertz (THz) electromagnetic fields, are provided. The methods and apparatus employ polarization detection devices and controllers to maintain or vary the polarization of modulated signals as desired. The methods and apparatus are provided to characterize electromagnetic fields by directing the electromagnetic field and a probe beam upon an electro-crystal and detecting the modulation of the resulting probe beam. Detection of the modulation of the probe beam is practiced by detecting and comparing the polarization components of the modulated probe beam. Aspects of the invention may be used to analyze or detect explosives, explosive related compounds, and pharmaceuticals, among other substances. A compact apparatus, modular optical devices for use with the apparatus, sample holders, and radiation source mounts are also disclosed. |
| FILED | Friday, January 11, 2008 |
| APPL NO | 12/013167 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/365 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808716 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Northeastern University (Boston, Massachusetts) |
| INVENTOR(S) | Wentao T. Lu (Malden, Massachusetts); Srinivas Sridhar (Newton, Massachusetts); Plarenta Vodo (Malden, Massachusetts); Patanjali Parimi (Belmont, Massachusetts); Yongjian Huang (Malden, Massachusetts) |
| ABSTRACT | Negative refraction in photonic crystals and diffraction grating is used to design plano-concave lenses to focus plane waves. Microwave experiments are carried out to demonstrate negative refraction and the performance of these lenses. Demonstration of negative refraction of visible light is also performed for the grism. These lenses can be used in optical circuits, astronomical applications, etc. |
| FILED | Tuesday, May 16, 2006 |
| APPL NO | 11/920613 |
| ART UNIT | 2873 — Optics |
| CURRENT CPC | Optical: Systems and elements 359/642 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809507 | Dwyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| INVENTOR(S) | Joseph R. Dwyer (W. Melbourne, Florida); Martin A. Uman (Alachua, Florida); Hamid K. Rassoul (W. Melbourne, Florida); Jason Jerauld (Gainesville, Florida); Douglas M. Jordan (Archer, Florida); Keith J. Rambo (Gainesville, Florida); Vladimir A. Rakov (Gainesville, Florida) |
| ABSTRACT | A lightning detection system (100) includes at least one lightning detector (101-103). The said lightning detector (101-103) includes at least one x-ray detector (110) for providing x-ray data responsive to x-rays received, and an electric field or magnetic field detector (115) for providing electric field or magnetic field data responsive to electric field or magnetic field received. At least one signal processor (122) is coupled to the x-ray detector and the electric field or magnetic field detector. The processor (122) determines whether lightning will strike or has struck proximate to the lightning detector(s) (101-103) based on the x-ray data and electric field or magnetic field data, and can provide a strike point indication having an accuracy of generally better than (100) m. |
| FILED | Monday, December 12, 2005 |
| APPL NO | 11/721280 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/4 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809736 | Greenwald et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Brown University (Providence, Rhode Island) |
| INVENTOR(S) | Amy Greenwald (Providence, Rhode Island); John R. Wicks (Kingston, Rhode Island) |
| ABSTRACT | A system and method of obtaining an importance ranking for a hierarchical collection of objects. The hierarchical collection of objects is represented as a tree containing a plurality of nodes, and each node to be ranked is represented as a respective leaf node of the tree. To obtain the ranking of the respective leaf nodes, the system and method locally ranks nodes contained in one or more sub-trees of the tree, in which each sub-tree has a depth equal to one. Next, the local rankings are effectively propagated up the tree, and the local rankings are aggregated at each level of the hierarchy, until a final importance ranking for the leaf nodes is obtained. |
| FILED | Tuesday, May 02, 2006 |
| APPL NO | 11/919262 |
| ART UNIT | 2161 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/755 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 07805980 | Kosterev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Anatoliy Kosterev (Houston, Texas) |
| ABSTRACT | A method for detecting a target fluid in a fluid sample comprising a first fluid and the target fluid using photoacoustic spectroscopy (PAS), comprises a) providing a light source configured to introduce an optical signal having at least one wavelength into the fluid sample; b) modulating the optical signal at a desired modulation frequency such that the optical signal generates an acoustic signal in the fluid sample; c) measuring the acoustic signal in a resonant acoustic detector; and d) using the phase of the acoustic signal to detect the presence of the target fluid. |
| FILED | Wednesday, February 09, 2005 |
| APPL NO | 10/597844 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/24.20 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07806410 | El-Aini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | United Technologies Corporation (Hartford, Connecticut) |
| INVENTOR(S) | Yehia M. El-Aini (Tequesta, Florida); William S. Mitchell (Palm Beach Garden, Florida); Lawrence P. Roberts (North Palm Beach, Florida); Stuart K. Montgomery (Jupiter, Florida); Gary A. Davis (Camarillo, California) |
| ABSTRACT | A stationary labyrinth seal system includes a seal housing having an annular cavity, a plurality of damping devices, and a retaining ring. The damping devices are positioned within the annular cavity and are maintained within the annular cavity by the retaining ring. |
| FILED | Tuesday, February 20, 2007 |
| APPL NO | 11/708287 |
| ART UNIT | 3676 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Seal for a joint or juncture 277/413 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807097 | Tucker |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Dennis S. Tucker (Huntsville, Alabama) |
| ABSTRACT | A process for producing foamed aluminum in space comprising the steps of: heating aluminum until it is molten; applying the force of gravity to the molten aluminum; injecting gas into the molten aluminum to produce molten foamed aluminum; and allowing the molten foamed aluminum to cool to below melting temperature. The apparatus for carrying out this invention comprises: a furnace which rotates to simulate the force of gravity and heats the aluminum until it is molten; a door on the furnace, which is opened for charging the aluminum into the furnace, closed for processing and opened again for removal of the foamed aluminum; a gas injection apparatus for injecting gas into the molten aluminum within the furnace; and an extraction apparatus adjacent the door for removing the foamed aluminum from the furnace. |
| FILED | Monday, May 19, 2008 |
| APPL NO | 12/123170 |
| ART UNIT | 1793 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Metallurgical apparatus 266/213 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07808353 | Eskridge et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Richard H. Eskridge (Joppa, Alabama); Michael H. Lee (Huntsville, Alabama); Adam K. Martin (Huntsville, Alabama); Peter J. Fimognari (Monson, Massachusetts) |
| ABSTRACT | A coil system for a plasmoid thruster includes a bias coil, a drive coil and field coils. The bias and drive coils are interleaved with one another as they are helically wound about a conical region. A first field coil defines a first passage at one end of the conical region, and is connected in series with the bias coil. A second field coil defines a second passage at an opposing end of the conical region, and is connected in series with the bias coil. |
| FILED | Wednesday, August 23, 2006 |
| APPL NO | 11/513433 |
| ART UNIT | 2832 — Semiconductors/Memory |
| CURRENT CPC | Inductor devices 336/170 |
| VIEW PATENT | @ USPTO: Full Text PDF |
07808628 — Method for nanoscale spatial registration of scanning probes with substrates and surfaces
| US 07808628 | Wade |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Lawrence A. Wade (La Canada-Flintridge, California) |
| ABSTRACT | Embodiments in accordance with the present invention relate to methods and apparatuses for aligning a scanning probe used to pattern a substrate, by comparing the position of the probe to a reference location or spot on the substrate. A first light beam is focused on a surface of the substrate as a spatial reference point. A second light beam then illuminates the scanning probe being used for patterning. An optical microscope images both the focused light beam, and a diffraction pattern, shadow, or light backscattered by the illuminated scanning probe tip of a scanning probe microscope (SPM), which is typically the tip of the scanning probe on an atomic force microscope (AFM). Alignment of the scanning probe tip relative to the mark is then determined by visual observation of the microscope image. This alignment process may be repeated to allow for modification or changing of the scanning probe microscope tip. |
| FILED | Wednesday, June 21, 2006 |
| APPL NO | 11/472596 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/153 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07809521 | Burke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Gary R. Burke (Moorpark, California); Yuan Chen (Glendale, California); Douglas J. Sheldon (Valencia, California) |
| ABSTRACT | A high resolution circuit and method for facilitating precise measurement of on-chip delays for FPGAs for reliability studies. The circuit embeds a pulse generator on an FPGA chip having one or more groups of LUTS (the “LUT delay chain”), also on-chip. The circuit also embeds a pulse width measurement circuit on-chip, and measures the duration of the generated pulse through the delay chain. The pulse width of the output pulse represents the delay through the delay chain without any I/O delay. The pulse width measurement circuit uses an additional asynchronous clock autonomous from the main clock and the FPGA propagation delay can be displayed on a hex display continuously for testing purposes. |
| FILED | Friday, February 29, 2008 |
| APPL NO | 12/040459 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/125 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 07807361 | Khatib |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Hasan Khatib (Madison, Wisconsin) |
| ABSTRACT | Nucleic acid molecules comprising a SNP site at position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), which SNP indicates a desirable productive life in a dairy cattle. Also disclosed are an array or a kit comprising the same, a method for detecting the SNPs, a method for progeny testing of cattle, and a method for selectively breeding of cattle. |
| FILED | Wednesday, January 17, 2007 |
| APPL NO | 11/624053 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807406 | Obendorf et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Cornell Research Foundation, Inc. (Ithaca, New York) |
| INVENTOR(S) | Ralph L. Obendorf (Ithaca, New York); Takashi Ueda (Fort Myers, Florida) |
| ABSTRACT | The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described. The method includes providing a fagopyritol synthase, providing a substrate comprising a galactosyl donor and a galactosyl acceptor, and combining the fagopyritol synthase with the substrate under conditions effective produce a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor. |
| FILED | Friday, May 09, 2003 |
| APPL NO | 10/435226 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/69.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807721 | Nolen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Biosensory Inc. (Putnam, Connecticut); Bedouklan Research, Inc. (Danbury, Connecticut); The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | James A. Nolen (West Greenwich, Rhode Island); Robert H. Bedoukian (West Redding, Connecticut); Robert E. Maloney (Bethel, Connecticut); Daniel L. Kline (Gainesville, Florida) |
| ABSTRACT | Composition for inhibiting the ability of mosquitoes to locate a target by olfactory emissions of the target comprise a composition of at least one inhibiting compound selected from the group consisting of 3-methyl-1-alkene-3-ols of the formula: and 3-methyl-1-alkyn-3-ols of the formula: wherein R1 and R2 are each independently a saturated or unsaturated aliphatic hydrocarbon group containing from 1 to about 12 carbon atoms, in a vehicle base that is a porous or waxy medium. The composition being capable of dispensing the inhibiting compound in an non-lethal amount effective to inhibit the ability of mosquitoes to sense a target in a three dimensional environmental space. |
| FILED | Thursday, October 20, 2005 |
| APPL NO | 11/254367 |
| ART UNIT | 1616 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/739 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807869 | Schnabel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Clemson University Research Foundation (, None) |
| INVENTOR(S) | Guido Schnabel (Clemson, South Carolina); Ralph Scorza (Shepherdstown, West Virginia); Desmond R. Layne (Seneca, South Carolina) |
| ABSTRACT | Transgenic plants, plant tissue, and propagation materials are disclosed that exhibit or convey increased resistance to pathogens of multiple higher-order phylogenetic lineages. The disclosed transgenic plants and plant tissues include plant cells containing a DNA construct encoding Gastrodia Anti-Fungal Protein (GAFP), also known as gastrodianin, an anti-fungal gene naturally occurring in a Chinese orchid, Gastrodia elata. Transgenic plants disclosed include herbaceous plants as well as woody plants, including fruit trees. Disclosed transgenic plants can also be beneficially utilized as rootstock, for instance rootstock for stone fruit crops such as peach, thereby conferring enhanced disease resistance to the rootstock without genetically altering the scion. |
| FILED | Thursday, June 01, 2006 |
| APPL NO | 11/445450 |
| ART UNIT | 1638 — Organic Chemistry |
| CURRENT CPC | Multicellular living organisms and unmodified parts thereof and related processes 8/279 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 07807182 | Laal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado); New York University (New York, New York) |
| INVENTOR(S) | Suman Laal (Croton-on-Hudson, New York); Susan Zolla-Pazner (New York, New York); John T. Belisle (Fort Collins, Colorado) |
| ABSTRACT | A number of protein and glycoprotein antigens secreted by Mycobacterium tuberculosis (Mtb) have been identified as “early” Mtb antigens on the basis early antibodies present in subjects infected with Mtb prior to the development of detectable clinical disease. Epitope-bearing peptide fragments of these early Mtb antigens, in particular of an 88 kDa secreted protein, GlcB (SEQ ID NO:106) and of Mtb antigen MPT51 (SEQ ID NO:107) have been identified. These peptides, variants thereof, peptide multimers thereof that include two or more repeats of one or more of the peptides, and fusion polypeptides that include early Mtb antigenic proteins, peptides or both, are useful in immunoassay methods for early, rapid detection of TB in a subject. Preferred immunoassays detect the antibodies in the subject's urine. Also provided are antigenic compositions, kits and methods to useful for detecting an early Mtb antibodies. The antigenic proteins and peptides are also used in vaccine compositions. |
| FILED | Friday, August 02, 2002 |
| APPL NO | 10/210884 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/248.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807374 | Richardson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Bruce Richardson (Ann Arbor, Michigan); Qianjin Lu (Ann Arbor, Michigan) |
| ABSTRACT | The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases. |
| FILED | Monday, October 20, 2008 |
| APPL NO | 12/254550 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807458 | Schiller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Department of Veterans Affairs (Washington, District of Columbia); The University of Miami (Miami, Florida) |
| INVENTOR(S) | Paul C. Schiller (Miami Beach, Florida); Gianluca D'Ippolito (North Miami Beach, Florida) |
| ABSTRACT | Described herein are post natal, multilineage inducible cells (MIAMI cells). In some examples, the cells are isolated from non fractionated, adult (males and females 3 to 72 years old) human bone marrow under cell culture conditions, which are believed to resemble an in vivo niche microenvironment in which primitive multipotent cells exist. MIAMI cells have a unique profile of molecular markers, and can be maintained in vitro (for more than 50 population doublings) without detectable changes in their characteristic molecular profile. MIAMI cells can be differentiated into mesodermal, neuroectodermal, and endodermal cell lineages. Methods of isolating, differentiating and using MIAMI cells are also described. |
| FILED | Thursday, January 29, 2004 |
| APPL NO | 10/544021 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/325 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807623 | Pisegna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Joseph R. Pisegna (Santa Monica, California); Stephen Wank (Potomac, Maryland) |
| ABSTRACT | This invention pertains to the discovery administration of a CCK receptor agonist can increase urinary sodium excretion and/or free water excretion in a mammal. CCK receptor agonist can thereby be used in the treatment of conditions such high blood pressure, fluid retention associated with heart failure, fluid retention associated with acute or chronic kidney failure, fluid retention associated with cirrhosis, fluid retention associated with liver failure, calcium kidney stones, nephrogenic diabetes insipidus, and renal tubular acidosis. |
| FILED | Friday, December 08, 2006 |
| APPL NO | 11/608667 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 07807138 | Berger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Metabolon, Inc. (Durham, North Carolina) |
| INVENTOR(S) | Alvin Berger (Raleigh, North Carolina); Imran A. Shah (Chapel Hill, North Carolina) |
| ABSTRACT | Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring of drug efficacy. |
| FILED | Friday, August 17, 2007 |
| APPL NO | 11/840466 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/9.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 07807148 | Comer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Stratatech Corporation (Madison, Wisconsin) |
| INVENTOR(S) | Allen Comer (Madison, Wisconsin); Lynn-Allen Hoffmann (Madison, Wisconsin) |
| ABSTRACT | The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue. |
| FILED | Wednesday, May 19, 2004 |
| APPL NO | 10/848646 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 07806275 | Murphy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Interior, The Bureau of Reclamation (Washington, District of Columbia); Colorado Seminary (Denver, Colorado); Separation Systems Technology Inc. (San Diego, California) |
| INVENTOR(S) | Andrew Patrick Murphy (Littleton, Colorado); Balasingam Murugaverl (Golden, Colorado); Robert Lee Riley (La Jolla, California) |
| ABSTRACT | A chlorine resistant polyamide is formed from the reaction product of an amine and an acid chloride monomer wherein the acid chloride monomer is modified with electron-withdrawing groups that exhibit sufficient activity to (i) minimize any chlorination on both the amine and acid chloride side and (ii) minimize N-chlorination. A membrane is made from the polyamide and, in one application, the membrane is used in a desalination unit. |
| FILED | Wednesday, May 09, 2007 |
| APPL NO | 11/746140 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Liquid purification or separation 210/500.380 |
| VIEW PATENT | @ USPTO: Full Text PDF |
General Services Administration (GSA)
| US 07806368 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | West Virginia University (Morgantown, West Virginia) |
| INVENTOR(S) | James E. Smith (Bruceton Mills, West Virginia); Roy S. Nutter, Jr. (Morgantown, West Virginia); Gregory J. Thompson (Morgantown, West Virginia); Zenovy S. Wowczuk (Morgantown, West Virginia); Gerald M. Angle, II (Morgantown, West Virginia) |
| ABSTRACT | A roll-on/roll-off, aircraft-borne sensor pod deployment system having an operator station and a sensor pallet system and method of using same. The operator station has a base platform, a shelter box mounted on the base platform for accommodating a human operator, and a computer installed inside the shelter box. The sensor pallet system has a base platform, a linear system mounted on the base platform, a rotational system mounted on the linear system, a mechanical arm attached to the rotational system, a sensor pod attached to the mechanical arm, and an electrical control system that provides power to the deployment system and controls movements of the sensor pallet system. In operation, the sensor pod can be retracted into a compact, stowing position, or extended out an opening in the aircraft for an unobstructed field of view. The deployment system optionally includes an apparatus and method for sealing the aircraft opening. |
| FILED | Wednesday, October 10, 2007 |
| APPL NO | 11/870140 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeronautics and astronautics 244/129.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
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This week's information is published in the FedInvent Patents report for Tuesday, October 05, 2010.
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There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2010/fedinvent-patents-20101005.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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