FedInvent™ Patents
Patent Details for Tuesday, December 06, 2011
This page was updated on Monday, March 27, 2023 at 02:06 AM GMT
Department of Defense (DOD)
| US 08069606 | Saur |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Thomas W. Saur (Dearborn, Michigan) |
| ABSTRACT | This tool makes it possible to more conveniently handle the “selector” element on a conventional M16/M4 family weapon when the selector must be removed or reinserted. As will be appreciated by those in the gun repair trade, in the disassembly or reassembly of such weapons the handling of the selector element is a tricky and painstaking activity. This disclosed tool handily is an assist in such activities. The tool is inserted in the opening in the receiver of the selector element and rotated. An offset circular cam means on the tool when rotated will handily depress the detent element (which necessarily must be done and it also has a spring beneath it). A bumper end cap at the distal end of the tool will carefully engage the selector element to gently push on it if needed (or in the reverse operation for the tool to be gently backed away there from as the selector is repositioned into the weapon). A longitudinal groove on the cam means will signal to the user when the proper rotation has been achieved to adequately depress said detent element. |
| FILED | Wednesday, April 14, 2010 |
| APPL NO | 12/759821 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Firearms 042/108 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08069648 | Snyder et al. |
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| ASSIGNEE(S) | United Technologies Corporation (Hartford, Connecticut) |
| INVENTOR(S) | Timothy S. Snyder (Glastonbury, Connecticut); Francisco J. Cunha (Avon, Connecticut) |
| ABSTRACT | A cooling system for a turbine exhaust assembly comprises an annular case, a flowpath ring and a splash plate. The flowpath ring is coaxially disposed within the annular case. The splash plate extends axially between the annular case and the flowpath ring. A plurality of cooling fluid apertures is formed in the annular case, in order to provide cooling fluid flow onto the splash plate. A plurality of impingement holes is formed in the splash plate, in order to provide impingement flow onto the flowpath ring. |
| FILED | Thursday, July 03, 2008 |
| APPL NO | 12/167780 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Power plants 060/262 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08069767 | Deckard et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Aaron Deckard (Wheatland, Indiana); Michael Holzmeyer (Bloomfield, Indiana); James Buechler (Jasper, Indiana) |
| ABSTRACT | An armament system for aircraft includes gun mount and ejection system for a machine gun. The gun mount and ejection system includes an ejection chute assembly including a hopper positioned intermediate the uprights of a carriage supporting the machine gun. |
| FILED | Wednesday, September 30, 2009 |
| APPL NO | 12/571405 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ordnance 089/33.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08069770 | Martin et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Curtis A. Martin (Damascus, Maryland); Bruce J. Wells (Middletown, Maryland) |
| ABSTRACT | A method and device for protecting a surface. The device includes modular spaced armor assemblies having a ceramic face plate, a composite backing plate, and a lightweight low-density module therebetween. The modular spaced armor assemblies may be tiled to form a protective arrangement for protecting a desired surface. The lightweight low-density module includes one or more gas filled cavities. |
| FILED | Friday, April 24, 2009 |
| APPL NO | 12/429444 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ordnance 089/36.20 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08069791 | Kunstmann et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | John Kunstmann (King George, Virginia); Gregory Chicchirichi (King George, Virginia) |
| ABSTRACT | A sabot system is defined by a tubular arrangement of curvilinear segments with the tubular arrangement being closed on a first end thereof and open on a second end thereof. The tubular arrangement defines a first outer diameter at its first end and a second and larger outer diameter at its second end. Each segment is made from an elastic material such that when the tubular arrangement is compressed radially at its second end, each of the segments stores a spring force. |
| FILED | Wednesday, March 31, 2010 |
| APPL NO | 12/799012 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ammunition and explosives 12/520 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08069801 | Ott et al. |
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| ASSIGNEE(S) | Harbor Wing Technologies, Inc. (Seattle, Washington) |
| INVENTOR(S) | Mark T. Ott (Kailua, Hawaii); David W. Hubbard (Stamford, Connecticut) |
| ABSTRACT | A steerable wing-type sail system for a wind powered craft. The system includes first and second secondary airfoils and that are spaced outwardly to the sides of the plane of the main sail, and that are positioned rearwardly of the trailing edge of the sail. The secondary airfoils are selectively pivotable so as to steer the main sail in one direction or the other. The main sail is also provided with a pivoting flap at its trailing edge, which pivots simultaneously with and in the same direction as the secondary airfoils. The secondary airfoils are carried on elongate horizontal booms mounted near the mid-span height of the main sail. The secondary airfoils pivot about vertical axes at the distal ends of the booms, and are operated by control cables that are retracted and paid out by linear actuators or similar mechanisms. The craft may be multi-hull vessel, such as a catamaran. The control mechanism for the secondary airfoils may operate the airfoils in response to signals received from one or more onboard sensors. The system is suitable for use on an autonomous unmanned surface vessel (AUSV). |
| FILED | Monday, May 10, 2010 |
| APPL NO | 12/800212 |
| ART UNIT | 3617 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ships 114/102.290 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08069806 | Karafiath |
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| ASSIGNEE(S) | The United States of Americas as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Gabor Karafiath (Silver Spring, Maryland) |
| ABSTRACT | The invention is directed towards a watercraft module and a connectorless sea train including two or more of the watercraft modules. The watercraft modules in the sea train are formed in a bow-to-stern relationship and are held together by compression forces. Each module includes a hull having a bow end having a substantially V-shaped profile, and a stern end having either a continuous end or a substantially V-shaped notch cut therein. The size and shape of the substantially V-shaped notch is substantially similar to the size and shape of the substantially V-shaped profile of the bow end. In the sea train having two or more watercraft modules, the substantially V-shaped profile of the bow end of a trailing watercraft is received in the substantially V-shaped notch at the stern of a leading watercraft. |
| FILED | Tuesday, August 05, 2008 |
| APPL NO | 12/228321 |
| ART UNIT | 3617 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ships 114/248 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08069835 | Hergart et al. |
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| ASSIGNEE(S) | Caterpillar Inc. (Peoria, Illinois) |
| INVENTOR(S) | Carl-Anders Hergart (Peoria, Illinois); John T. Vachon (Peoria, Illinois); Kevin P. Duffy (Metamora, Illinois) |
| ABSTRACT | The present disclosure provides an internal combustion engine having an engine housing with at least one cylinder that has diameter less than about 3 inches. A fuel injector is provided and disposed at least partially within the at least one cylinder, and includes a plurality of outlet orifices having a diameter between about 50 microns and about 125 microns, or about 0.05 millimeters and about 0.125 millimeters. The injector may include more than one set of separately controllable fuel outlet orifices, at least one of which could have an average diameter between about 0.05 millimeters and about 0.125 millimeters. The disclosure further provides a method of operating an internal combustion engine. The method includes the steps of rotating an engine crank shaft of the engine at a speed greater than about 5000 revolutions per minute, injecting a quantity of fuel into each of the cylinders, and burning at least every fourth piston stroke a sufficient quantity of the injected fuel to yield a brake mean effective pressure of at least about 200 lbs. per square inch. |
| FILED | Friday, January 19, 2007 |
| APPL NO | 11/655428 |
| ART UNIT | 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Internal-combustion engines 123/294 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070090 | Tayman |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Steven K. Tayman (Alexandria, Virginia) |
| ABSTRACT | Systems and methods for transitioning an aircraft between helicopter and fixed wing flight modes are provided. In one embodiment, an aircraft comprises a plurality of wings each having a spar and a flap; a flap actuator configured to move the flap with respect to the spar; and a center section rotatably coupled to each spar. The center section includes at least one spar actuator configured to rotate at least one of the wings about a rotational axis of the spar when the aircraft transitions between helicopter and fixed wing flight modes. |
| FILED | Wednesday, June 17, 2009 |
| APPL NO | 12/486023 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeronautics and astronautics 244/7.C00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070092 | Bouldin et al. |
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| ASSIGNEE(S) | Honeywell International Inc. (Morristown, New Jersey) |
| INVENTOR(S) | Bruce Dan Bouldin (Phoenix, Arizona); Ricardo Burdisso (Blacksburg, Virginia) |
| ABSTRACT | A strut support system for a ducted fan unmanned aerial vehicle to suppress noise comprising: a ducted fan fuselage that defines an opening; an engine that extends longitudinally through the opening in the fuselage; a drive mechanism rotatably mounted to the engine, wherein a fan is mounted on the drive mechanism within a duct defined by the opening; and a plurality of struts extending between the ducted fan fuselage and the engine each comprising a first leg and a second leg joined together by a curvilinear junction, wherein the first leg is attached to the ducted fan fuselage and the second leg is attached to the engine, wherein the plurality of struts are positioned upstream of the fan, wherein the junction between the first leg of each of the plurality of struts and the ducted fan fuselage is outside the highlight of the ducted fan fuselage's leading edge. |
| FILED | Friday, October 31, 2008 |
| APPL NO | 12/262428 |
| ART UNIT | 3643 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeronautics and astronautics 244/34.A00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070103 | Collette |
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| ASSIGNEE(S) | Honeywell International Inc. (Morristown, New Jersey) |
| INVENTOR(S) | Daniel Ross Collette (Albuquerque, New Mexico) |
| ABSTRACT | A fuel line air trap for an unmanned aerial vehicle has a vessel in-line with a fuel line, fuel line connectors, and fuel inlet and outlet stems. The vessel contains an inlet at a distal end and an outlet at a proximal end. The fuel line connectors are attached to the vessel at the inlet and at the outlet to connect the fuel line to the vessel. The fuel inlet stem attaches to the vessel at the inlet and a fuel outlet stem attaches to the vessel at the outlet. Both the fuel inlet stem and fuel outlet stem protrude into the vessel a predetermined distance such that a gap exists between them. As air bubbles enter the gap in the fuel line air trap, they separate from the flow of fuel and migrate to the exterior walls of the vessel. The air bubbles are purged during remain trapped refueling. |
| FILED | Thursday, July 31, 2008 |
| APPL NO | 12/183277 |
| ART UNIT | 3753 — Fluid Handling and Dispensing |
| CURRENT CPC | Aeronautics and astronautics 244/135.R00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070682 | Zhu |
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| ASSIGNEE(S) | The University of Connecticut (Farmington, Connecticut) |
| INVENTOR(S) | Quing Zhu (Mansfield Center, Connecticut) |
| ABSTRACT | Methods and apparatus for medical imaging using diffusive optical tomography and fluorescent diffusive optical tomography and ultrasound are disclosed. In one embodiment, the probe comprises emitters and detectors that are inclined at an angle of about 1 to about 30 degrees to a surface of the probe that contacts tissue. In another embodiment, the scanned volume is divided into an inclusion region and a background region. Different voxel sizes are used in the inclusion region and the background region. Appropriate algorithms facilitate a reconstruction of the inclusion region to determine structural and functional features of the inclusion. |
| FILED | Thursday, July 19, 2007 |
| APPL NO | 11/780200 |
| ART UNIT | 3777 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Surgery 6/437 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070700 | Kazerooni et al. |
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| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Homayoon Kazerooni (Berkeley, California); Jean-Louis Racine (Rockville, Maryland); Andrew Chu (Berkeley, California); Adam Zoss (Berkeley, California) |
| ABSTRACT | A lower extremity enhancer to be worn by a user includes two leg supports having a plurality of jointed links. Proximal ends of the leg supports are connected to a back frame. Distal ends of the leg supports are connected to two foot links. The leg supports are powered by a plurality of actuators adapted to apply torques to the leg supports in response to movement of the user's legs. |
| FILED | Thursday, November 19, 2009 |
| APPL NO | 12/622362 |
| ART UNIT | 3772 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Surgery: Splint, brace, or bandage 62/16 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070920 | Lyding et al. |
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| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Joseph W. Lyding (Champaign, Illinois); Scott W. Schmucker (Champaign, Illinois) |
| ABSTRACT | The invention provides methods for sharpening the tip of an electrical conductor. The methods of the invention are capable of producing tips with an apex radius of curvature less than 2 nm. The methods of the invention are based on simultaneous direction of ionized atoms towards the apex of a previously sharpened conducting tip and application of an electric potential difference to the tip. The sign of the charge on the ions is the same as the sign of the electric potential. The methods of the invention can be used to sharpen metal wires, metal wires tipped with conductive coatings, multi-walled carbon nanotubes, semiconducting nanowires, and semiconductors in other forms. |
| FILED | Thursday, April 26, 2007 |
| APPL NO | 11/740678 |
| ART UNIT | 1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Chemistry: Electrical and wave energy 24/192.340 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070973 | Chen et al. |
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| ASSIGNEE(S) | Alcatel Lucent (Paris, France) |
| INVENTOR(S) | Young-Kai Chen (Berkeley Heights, New Jersey); Andreas Bertold Leven (Gillette, New Jersey); Yang Yang (Gillette, New Jersey) |
| ABSTRACT | Apparatus including: a substrate layer having a substantially planar top surface; an optically conductive peak located and elongated on, and spanning a first thickness measured in a direction generally away from, the top surface; the optically conductive peak having first and second lateral walls each including distal and proximal lateral wall portions, the proximal lateral wall portions intersecting the top surface; and first and second sidewall layers located on the distal lateral wall portions, the sidewall layers not intersecting the top surface and spanning a second thickness that is less than the first thickness measured in the same direction. |
| FILED | Monday, September 29, 2008 |
| APPL NO | 12/286224 |
| ART UNIT | 1713 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Etching a substrate: Processes 216/80 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071006 | Thottupurathu |
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| ASSIGNEE(S) | General Electric Company (Schenectady, New York) |
| INVENTOR(S) | Gopakumar Thottupurathu (Overland Park, Kansas) |
| ABSTRACT | The present application thus provides a composite composition comprising PTFE and zeolite. According to another aspect, the present application provides a method for making a composite article comprising bonding zeolite to PTFE. According to still yet another aspect of the present application, a method for separating components of the mixture comprising contacting the mixture with a composite composition comprising PTFE and zeolite is disclosed. |
| FILED | Tuesday, August 12, 2008 |
| APPL NO | 12/190233 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Plastic and nonmetallic article shaping or treating: Processes 264/288.800 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071031 | Byrne |
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| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | Robert H. Byrne (St. Petersburg, Florida) |
| ABSTRACT | A device for the precise and accurate potentiometric pH measurements in situ. Embodiments of a potentiometric device according to the invention consist of one or more glass pH-sensitive electrodes connected to a potentiometer. A key feature of the device is that, rather than being calibrated conventionally with buffers, it can be calibrated with an in situ device that measures pH spectrophotometrically. Spectrophotometric pH measurements obtained via sulfonephthalein absorbance measurements are inherently calibrated (do not require buffers). Thus, devices according to the invention allow for continuous potentiometric pH measurements with occasional spectrophotometric calibrations. The spectrophotometric calibration device consists of a spectrophotometer with associated pumps for combining a sulfonephthalein pH indicator with the aqueous medium whose pH is to be measured. The device will record potentiometric pH measurements for an extended period of time until the spectrophotometric device is autonomously activated for another calibration. In this manner precise and accurate pH measurements can be obtained continuously in the environment, and the low energy expenditure of the potentiometric device provides excellent endurance. Also provided is a method and associated devices for spectrophotometrically determining the salinity of an aqueous medium. |
| FILED | Friday, March 25, 2011 |
| APPL NO | 13/072230 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing 422/82.10 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071054 | Oh et al. |
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| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Sang-Hyun Oh (Minneapolis, Minnesota); Amarendra Kumar Singh (Jersey City, New Jersey); Yanting Zhang (Goleta, California); Dharmakirthi Nawarathna (Tustin, California); Unyoung Kim (Goleta, California); Patrick Sean Daugherty (Santa Barbara, California); Hyongsok Soh (Santa Barbara, California); Brian Scott Ferguson (Goleta, California) |
| ABSTRACT | A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally includes separate buffer and sample streams. A magnetic field gradient applied to the sorting station deflects the flow path of magnetic particles (which selectively label the target species) from a sample stream into a buffer stream. The buffer stream leaving the sorting station is used to detect or further process purified target species labeled with the magnetic particles. |
| FILED | Monday, August 30, 2010 |
| APPL NO | 12/871788 |
| ART UNIT | 1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing 422/527 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071082 | Zugates et al. |
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| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Gregory T. Zugates (Cambridge, Massachusetts); Andreas Zumbuehl (Bern, Switzerland); Robert S. Langer (Newton, Massachusetts); Daniel G. Anderson (Sudbury, Massachusetts) |
| ABSTRACT | Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers. |
| FILED | Friday, July 20, 2007 |
| APPL NO | 11/780754 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/78.370 |
| VIEW PATENT | @ USPTO: Full Text PDF |
08071282 — Method of storing red blood cells with an acidic additive solution under oxygen depletion
| US 08071282 | Bitensky et al. |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Mark W Bitensky (Waban, Massachusetts); Tatsuro Yoshida (West Newton, Massachusetts) |
| ABSTRACT | There is provided compositions and methods for the storage of red blood cells. The compositions are additive solutions comprising adenine, dextrose, mannitol, NaH2PO4, and optionally NaCl and/or NH4Cl. Composition are preferably used with oxygen-depletion refrigerated storage of red blood cells and may optionally be employed with nutrient supplements extending the useful shelf life of stored blood. |
| FILED | Friday, May 13, 2005 |
| APPL NO | 11/128576 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071309 | Ecker et al. |
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| ASSIGNEE(S) | Ibis Biosciences, Inc. (Carlsbad, California) |
| INVENTOR(S) | David J. Ecker (Encinitas, California); Richard H. Griffey (Vista, California); Rangarajan Sampath (San Diego, California); Steven A. Hofstadler (Oceanside, California); John McNeil (La Jolla, California); Stanley T. Crooke (Carlsbad, California); Lawrence Blyn (Mission Viejo, California); Ray Ranken (Encinitas, California); Thomas A. Hall (Oceanside, California) |
| ABSTRACT | The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples. |
| FILED | Tuesday, October 30, 2007 |
| APPL NO | 11/930002 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.120 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071322 | Zhang |
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| ASSIGNEE(S) | Epitomics, Inc. (Burlingame, California) |
| INVENTOR(S) | Dongxiao Zhang (Moraga, California) |
| ABSTRACT | The invention provides a method of identifying an antigen that is present in different amounts in two different samples. In general, the methods involve generating a first and second distinguishably labeled population of antibodies that reactive to the two samples, contacting the first and second labeled populations of antibodies with a plurality of antigens; and identifying any resultant antigens that are differentially bound by the first and second populations of antibodies. The antigens may be on the surface of cells e.g., animal cells, or on a solid support. Once identified, the nucleic acid encoding an antigen of interest may be identified and sequenced to reveal the identity of the antigen of interest. Kits for performing the methods are also provided. The methods find most use in medical and research applications, in particular, for identifying cell surface targets for immunotherapy and drug discovery. |
| FILED | Monday, November 10, 2003 |
| APPL NO | 10/705109 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.230 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071327 | Reed et al. |
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| ASSIGNEE(S) | Sanford-Burnham Medical Research Institute (La Jolla, California) |
| INVENTOR(S) | John C. Reed (Rancho Santa Fe, California); Quinn Deveraux (San Diego, California); Guy S. Salvesen (Encinitas, California); Ryosuke Takahashi (Kokubunji, Japan); Natalie Roy (La Jolla, California) |
| ABSTRACT | The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive ex vivo by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells. |
| FILED | Monday, August 02, 2010 |
| APPL NO | 12/848936 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/18 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071340 | Nadeau et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Lloyd J. Nadeau (Mexico Beach, Florida); Heather R. Luckarift (Port St Joe, Florida); Jim C. Spain (Atlanta, Georgia) |
| ABSTRACT | A process for the production of ortho-aminophenolic analogs of chloramphenicol using a biocatalyst consisting of pure enzymes, partially purified enzymes, cell lysate, intact cells, or a metal reaction linked with a subsequent enzymatic reaction. The biocatalyst is an enzyme system that makes use of a nitroreductase enzyme that initially reduces the nitroarene to the hydroxylaminoarene and a mutase enzyme that converts the hydroxylaminoarene to an ortho-aminophenol. The biocatalyst can also consist of a coupled, two-step metal and enzyme reaction in which the metal, such as zinc, catalyzes the transformation of the nitroarene to the hydroxylaminoarene and the mutase then catalyzes the transformation of hydroxylaminoarene to the corresponding ortho-aminophenol. |
| FILED | Thursday, November 02, 2006 |
| APPL NO | 11/602435 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/128 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071344 | Schultz et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Peter G. Schultz (La Jolla, California); Lei Wang (San Diego, California) |
| ABSTRACT | Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs. |
| FILED | Friday, October 26, 2007 |
| APPL NO | 11/978182 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/183 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071373 | Warren et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sanofi Pasteur Vaxdesign Corp. (Orlando, Florida); Virginia Commonwealth University (Richmond, Virginia) |
| INVENTOR(S) | William L. Warren (Orlando, Florida); Donald Drake, III (Orlando, Florida); Janice Moser (Orlando, Florida); Inderpal Singh (Oviedo, Florida); Haifeng Song (Germantown, Maryland); Eric Mishkin (Winter Springs, Florida); John G. Tew (Mechanicsville, Virginia) |
| ABSTRACT | The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. |
| FILED | Thursday, June 15, 2006 |
| APPL NO | 11/453046 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/347 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071546 | Cabrales et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | La Jolla Bioengineering Institute (La Jolla, California); Albert Einstein College of Medicine of Yeshiva University (Bronx, New York) |
| INVENTOR(S) | Pedro Cabrales (San Diego, California); Amy Tsai (San Diego, California); Seetharama A. Acharya (Cresskill, New Jersey); Belur N. Manjula (Cresskill, New Jersey) |
| ABSTRACT | The present invention is directed to uses of PEGylated albumins which include methods of treating reduced functional capillary density, reduced blood volume, septic shock and cardiac arrhythmia in a subject, which comprise administering to the subject a therapeutically effective amount of a PEGylated albumin. |
| FILED | Friday, June 09, 2006 |
| APPL NO | 11/921689 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/12 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071706 | Stafslien et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | NDSU Research Foundation (Fargo, North Dakota) |
| INVENTOR(S) | Shane Jeremy Stafslien (West Fargo, North Dakota); Bret Ja Chisholm (West Fargo, North Dakota); Alex J. Kugel (Fargo, North Dakota) |
| ABSTRACT | A polymer that is a polysiloxane polymer has Levofloxacin groups, or pharmaceutically acceptable salts thereof, attached via linkers. The linkers may be hydrolytically labile thereby providing a manner of releasing the Levofloxacin from the polymer. |
| FILED | Tuesday, February 10, 2009 |
| APPL NO | 12/378049 |
| ART UNIT | 1766 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Synthetic resins or natural rubbers 528/26 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071722 | Kaplan et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Hyoung-Joon Jin (Seoul, South Korea); Gregory Rutledge (Newton, Massachusetts); Sergey Fridrikh (Acton, Massachusetts) |
| ABSTRACT | The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo. |
| FILED | Friday, January 15, 2010 |
| APPL NO | 12/688014 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/353 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071794 | Pitner et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Becton, Dickinson and Company (Franklin Lakes, New Jersey) |
| INVENTOR(S) | J. Bruce Pitner (Durham, North Carolina); Douglas B. Sherman (Durham, North Carolina); Joseph Thomas (Raleigh, North Carolina) |
| ABSTRACT | Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus. |
| FILED | Monday, June 22, 2009 |
| APPL NO | 12/489145 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Organic compounds 549/289 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071799 | Olson |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Energy and Environmental Research Center Foundation (Grand Forks, North Dakota) |
| INVENTOR(S) | Edwin S. Olson (Grand Forks, North Dakota) |
| ABSTRACT | A method comprising providing a starting composition comprising a polyunsaturated fatty acid, a polyunsaturated fatty ester, a carboxylate salt of a polyunsaturated fatty acid, a polyunsaturated triglyceride, or a mixture thereof; self-metathesizing the starting composition or cross-metathesizing the starting composition with at least one short-chain olefin in the presence of a metathesis catalyst to form self-/cross-metathesis products comprising: cyclohexadiene; at least one olefin; and one or more acid-, ester-, or salt-functionalized alkene; and reacting cyclohexadiene to produce at least one cycloalkane or cycloalkane derivatives. A method for producing cycloalkanes for jet fuel by providing a starting composition comprising at least one selected from the group consisting of algal and polyunsaturated vegetable oils, subjecting the starting composition to metathesis to produce metathesis product comprising at least one olefin, cyclohexadiene, and at least one acid-, ester-, or salt-functionalized alkene, and reacting the at least one olefin and cyclohexadiene to form cycloalkane(s). |
| FILED | Thursday, January 29, 2009 |
| APPL NO | 12/361748 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Organic compounds 554/163 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071947 | Garman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Opto-Knowledge Systems, Inc. (Torrance, California) |
| INVENTOR(S) | John Garman (Long Beach, California); Nahum Gat (Manhattan Beach, California) |
| ABSTRACT | A variable aperture assembly for an infrared camera for use with optics having two or more f-numbers. The variable aperture assembly includes a variable iris disposed substantially along an axis of the infrared camera and is thermally connected to a cooling assembly. The variable iris is capable of causing an infrared radiation admitting opening to vary in size. The infrared radiation admitting openings of the variable aperture assembly can be circular or non-circular, including generally rectangular or racetrack shaped openings. The variable aperture assembly provides f-number matching by adjusting the infrared radiation admitting opening to the size necessary to effectively match the numerous f-numbers of the optics, or by adjusting to a size so that a fixed aperture on the radiation shield becomes the effective aperture stop, providing the f-number matching. |
| FILED | Tuesday, November 04, 2008 |
| APPL NO | 12/264864 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Radiant energy 250/352 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072095 | Lawrence et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Gary J. Lawrence (Merrimack, New Hampshire); Paul E. Gili (Mason, New Hampshire) |
| ABSTRACT | Techniques are disclosed for optimizing power consumption in electronic devices that operate on battery-based or scavenged power. The power scavenged or otherwise supplied by such devices may therefore last longer, allowing longer performance on a given charge (whether sourced from scavenged power, battery power, or a combination thereof). An energy distribution circuit can be used in conjunction with a hysteretic switch, wherein the hysteretic switch can be used to switch an energy storage element in-circuit (so that it can provide charge to sub-circuitry or components) when the charge stored on that element exceeds a given charge threshold; otherwise, the hysteretic switch presents as a high resistance or open circuit when the charge stored on the energy storage element drops below a lower recharge threshold. The energy distribution circuit can be configured for adaptively providing different discharge rates for different loads. |
| FILED | Tuesday, May 26, 2009 |
| APPL NO | 12/472279 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Electrical transmission or interconnection systems 37/31 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072117 | Zalalutdinov et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Cornell Research Foundation, Inc. (Ithaca, New York); Naval Research Laboratory (Washington, District of Columbia) |
| INVENTOR(S) | Maxim Zalalutdinov (Silver Springs, Maryland); Robert B. Reichenbach (Ithaca, New York); Keith Aubin (Freeville, New York); Brian H. Houston (Fairfax, Virginia); Jeevak M. Parpia (Ithaca, New York); Harold G. Craighead (Ithaca, New York) |
| ABSTRACT | A source signal is converted into a time-variant temperature field with transduction into mechanical motion. In one embodiment, the conversion of a source signal into the time-variant temperature field is provided by utilizing a micro-fabricated fast response, bolometer-type radio frequency power meter. A resonant-type micromechanical thermal actuator may be utilized for temperature read-out and demodulation. |
| FILED | Monday, February 20, 2006 |
| APPL NO | 11/358917 |
| ART UNIT | 2618 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Electrical generator or motor structure 310/306 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072289 | Itoh et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Tatsuo Itoh (Rolling Hills, California); Christophe Caloz (Montreal, Canada); I-Hsiang Lin (Mountain View, California); Hiroshi Okabe (Tokyo, Japan) |
| ABSTRACT | High-frequency couplers and coupling techniques are described utilizing artificial composite right/left-handed transmission line (CRLH-TL). Three specific forms of couplers are described; (1) a coupled-line backward coupler is described with arbitrary tight/loose coupling and broad bandwidth; (2) a compact enhanced-bandwidth hybrid ring coupler is described with increased bandwidth and decreased size; and (3) a dual-band branch-line coupler that is not limited to a harmonic relation between the bands. These variations are preferably implemented in a microstrip fabrication process and may use lumped-element components. The couplers and coupling techniques are directed at increasing the utility while decreasing the size of high-frequency couplers, and are suitable for use with separate coupler or couplers integrated within integrated devices. |
| FILED | Friday, May 16, 2008 |
| APPL NO | 12/122311 |
| ART UNIT | 2817 — Semiconductors/Memory |
| CURRENT CPC | Wave transmission lines and networks 333/118 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072302 | Liang et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| INVENTOR(S) | Yuanchang Liang (Seattle, Washington); Minoru Taya (Mercer Island, Washington) |
| ABSTRACT | Linear actuators (also known as inchworm actuators) including a magnetically actuatable member with a plurality of wings or blades made from a shape memory alloy (SMA) are described. The linear actuators include a bar and an actuator assembly, configured to achieve a linear displacement of the actuator assembly relative to the bar. The actuator assembly includes a housing, a magnetic trigger including an electromagnet and a permanent magnet, and the magnetically actuatable SMA member. Significantly, the wings/blades of the magnetically actuatable SMA member are coupled to the housing. Activation of the magnetic trigger causes the magnetically actuatable SMA member to move toward the magnetic trigger. The motion of the magnetically actuatable SMA can be converted to a linear displacement. The magnetically actuatable SMA can be implemented using a SMA exhibiting both ferromagnetic and SMA properties, or by a ferromagnetic mass coupled with a SMA (i.e., a ferromagnetic SMA composite). |
| FILED | Friday, September 05, 2008 |
| APPL NO | 12/205307 |
| ART UNIT | 2832 — Semiconductors/Memory |
| CURRENT CPC | Electricity: Magnetically operated switches, magnets, and electromagnets 335/229 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072383 | Martin et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Richard K. Martin (Springboro, Ohio); Jamie S. Velotta (Athens, Alabama); John F. Raquet (New Carlisle, Ohio) |
| ABSTRACT | A multicarrier modulation position determination method that includes deploying at least one known receiver with a known location and a second receiver with an unknown location. At least two signals of opportunity with different locations are obtained by both the receiver and the second receiver. The signals having a plurality of block data, the block data having block boundaries. The block boundaries including a beginning block boundary and an end block boundary. The block data further including a cyclic prefix at the beginning block boundary. Acquiring a plurality of data samples for at least a portion of the block data and correlating the attained signal of opportunity between the receivers. The correlating process includes the calculation of a time difference of arrival between the known receiver and the second receiver. The time difference of arrival is calculated by aligning the block boundaries and computing a single scalar statistical feature associated with each block. The location of the second receiver is calculated by using a plurality of single scalar statistical features. |
| FILED | Tuesday, May 26, 2009 |
| APPL NO | 12/471525 |
| ART UNIT | 3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Communications: Directive radio wave systems and devices 342/387 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072595 | Bastiaans et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Optech Ventures, LLC (Torrance, California) |
| INVENTOR(S) | Glenn Bastiaans (Torrance, California); Steve Hankins (Long Beach, California); Jerald Alan Cole (Long Beach, California) |
| ABSTRACT | A time correlated single photon counting system having a programmable delay generator triggered by a laser fire event detector. The system may be used for chemical agent detection based on Rayleigh scattering using optical time domain reflectometry techniques. The system may also be used for Raman detection using frequency to time transformations. |
| FILED | Tuesday, October 16, 2007 |
| APPL NO | 11/873337 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/301 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072609 | Trivedi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Sudhir Trivedi (Baltimore, Maryland); Venkataraman Swaminathan (Bridgewater, New Jersey); Chen-Chia Wang (Newark, Delaware) |
| ABSTRACT | An enhanced sensitivity laser vibrometer with increased output signal strength and more sensitive surface vibration detection, is provided by using a reflective mirror assembly to repeatedly bounce the sensing laser beam against the acoustic pressure-sensing diaphragm to magnify the acoustic incident pressure wave being detected. The enhancement in signal strength, in terms of power spectral density, is a function of the number of bounces squared and the detection of surface vibrations with a displacement of smaller than 4 picometers is demonstrated experimentally. |
| FILED | Tuesday, December 30, 2008 |
| APPL NO | 12/345861 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/486 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072772 | Zingher |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Oracle America, Inc. (Redwood Shores, California) |
| INVENTOR(S) | Arthur R. Zingher (Mountain View, California) |
| ABSTRACT | An apparatus includes a two-dimensional array of single-chip modules (SCMs) and at least one component. A respective SCM in the array includes at least a semiconductor die that is configured to communicate data signals by capacitive coupling using one or more proximity connectors in a first set of proximity connectors. The first set of proximity connectors are coupled to the semiconductor die. A second set of proximity connectors is coupled to at least the one component. At least the one component is coupled to semiconductor dies in two or more SCMs using one or more proximity connectors in the second set of proximity connectors thereby enabling communication of the data signals by capacitive coupling. |
| FILED | Wednesday, February 22, 2006 |
| APPL NO | 11/359814 |
| ART UNIT | 2835 — Electrical Circuits and Systems |
| CURRENT CPC | Electricity: Electrical systems and devices 361/782 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072996 | Chu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Tam-Anh Chu (Great Falls, Virginia) |
| ABSTRACT | The present invention is a method and apparatus to buffer data. A buffer memory of a first type stores data associated with a connection identifier corresponding to a channel in a network. The data is organized into at least one chunk based on a linked list. The connection identifier identifies a connection in the channel. The data is part of a data stream associated with the connection. A packet memory of a second type provides access to the stored data when a transfer condition occurs. |
| FILED | Thursday, October 25, 2007 |
| APPL NO | 11/924340 |
| ART UNIT | 2467 — Multiplex and VoIP |
| CURRENT CPC | Multiplex communications 370/412 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073017 | Hooper et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | William P. Hooper (Severna Park, Maryland); Glendon M. Frick (Lorton, Virginia); Benjamin P. Michael (Falling Waters, West Virginia) |
| ABSTRACT | A system and method for converting a pulsed beam of irradiation from a laser operating at a first wavelength to a pulsed beam of irradiation at a second, Stokes, wavelength. The system includes two Raman cells filled with the same Raman-active gas. The second cell receives a backward-propagating Stokes pulse beam from the first Raman cell, with the backward-propagating Stokes pulsed beam entering the second Raman cell in a direction opposite to the direction of travel of the incoming laser pulses at the first wavelength. The second Raman cell generates a high intensity output pulsed beam at the second, Stokes, wavelength. The system can produce a high intensity eye-safe pulsed beam. |
| FILED | Tuesday, February 23, 2010 |
| APPL NO | 12/711011 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Coherent light generators 372/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073079 | Ahmed |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Ahsen Ahmed (San Diego, California) |
| ABSTRACT | A threshold noise-canceling method comprising the steps of: receiving an angle-modulated signal; identifying in the angle-modulated signal potential threshold noise events that exceed a first threshold value; calculating average values of the phase of the angle-modulated signal before and after a potential threshold noise event; identifying every potential threshold noise event as a threshold noise event when the difference between the corresponding before and after average values of the phase is greater than a second threshold value; and canceling out each threshold noise event by adding to the phase of the angle-modulated signal a 2π phase shift of polarity opposite to that of the corresponding threshold noise event. |
| FILED | Monday, October 20, 2008 |
| APPL NO | 12/254483 |
| ART UNIT | 2611 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Pulse or digital communications 375/324 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073289 | Miller |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Stephen Miller (Ridgecrest, California) |
| ABSTRACT | The present invention relates to a method of using an image warping software algorithm to perform a real time alteration of a display scene running under the MICROSOFT WINDOWS OPERATING SYSTEM to mitigate the inherent distortion of a Stark lens cover. The image warping software algorithm alters the display scene and allows an observer to view the display scene as a single unbroken image when the display scene is distributed across multiple display screens. The purpose of the image warping software algorithm is to significantly reduce the distortion observed at the abutting edges of the joined display screens. |
| FILED | Wednesday, October 17, 2007 |
| APPL NO | 11/873592 |
| ART UNIT | 2624 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/284 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073333 | Bernasconi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Alcatel Lucent (Paris, France) |
| INVENTOR(S) | Pietro Arturo Bernasconi (Aberdeen, New Jersey); Jane D. LeGrange (Princeton, New Jersey) |
| ABSTRACT | According to one embodiment, a multiplex delay unit comprises an optical all-pass filter (OAPF) adapted to apply continuously tunable group delay to a wavelength division multiplexing (WDM) signal so that all of its WDM components are delayed by substantially the same delay time. The OAPF has a free spectral range (FSR) that matches spectral separation between carrier wavelengths of the WDM signal. Advantageously, an optical multiplex synchronizer suitable for feeding a synchronous optical switch fabric can be implemented as an integrated waveguide circuit using a plurality of such multiplex delay units. |
| FILED | Friday, November 16, 2007 |
| APPL NO | 11/941191 |
| ART UNIT | 2613 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Optical communications 398/85 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073342 | Caplan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | David O. Caplan (Westford, Massachusetts) |
| ABSTRACT | The present invention addresses the problem of transmitting optical signals with high extinction ratios using low-power drive signals. At present, low-power optical transmitters typically operate with modulation extinction ratios of, at best, about 10 dB. Embodiments of the present invention may achieve extinction ratios exceeding 20 dB using low-power drive signals of under 20 mW at data rates on the order of Gbits/sec. In addition, the modulation may be achieved with both low-power and low-fidelity drive waveforms, enabling conventional and often noisy high-speed, low-power electronics to generate high-extinction, high-fidelity optical waveforms. |
| FILED | Monday, May 05, 2008 |
| APPL NO | 12/151284 |
| ART UNIT | 2613 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Optical communications 398/201 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073555 | Fuller |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | United Technologies Corporation (Hartford, Connecticut) |
| INVENTOR(S) | James W. Fuller (Amston, Connecticut) |
| ABSTRACT | A method of estimating a basepoint includes a plurality of goals, wherein each goal has a desired value, receiving a plurality of sensor feedback signals from a controlled system, and receiving a plurality of predicted output values of the controlled system from a mathematical model. A desired change for a plurality of basepoint values is estimated in response to the goals, the feedback, and the predicted ooutput values. An actual change in basepoint values is calculated in response to a plurality of limits and the desired change for the plurality of basepoint values. The desired change is modified as necessary to hold the limits. The actual change in basepoint values is combined with last pass values of the plurality of basepoint values to produce an updated basepoint estimate. |
| FILED | Tuesday, May 06, 2008 |
| APPL NO | 12/115570 |
| ART UNIT | 2121 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Generic control systems or specific applications 7/31 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073627 | Ecker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Ibis Biosciences, Inc. (Carlsbad, California) |
| INVENTOR(S) | David J. Ecker (Encinitas, California); Richard H. Griffey (Vista, California); Rangarajan Sampath (San Diego, California); Steven A. Hofstadler (Vista, California); John McNeil (La Jolla, California); Stanley T. Crooke (Carlsbad, California) |
| ABSTRACT | The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity. |
| FILED | Friday, January 09, 2004 |
| APPL NO | 10/754415 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/19 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073797 | Ruffa |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Anthony A. Ruffa (Hope Valley, Rhode Island) |
| ABSTRACT | A method for solving a combinatorial optimization problem and applying the solutions to routing as employed in naval convoying and other transit point scheduling. The method involves isolating a plurality of vertices into open-ended zones with lengthwise boundaries. In each zone, a minimum length Hamiltonian path is found for each combination of boundary vertices, leading to an approximation for the minimum-length Hamiltonian Cycle. The method discloses that when the boundaries create zones with boundary vertices confined to the adjacent zones, the sets of candidate HPs are found by advancing one zone at a time, considering only the vertices in the zone in question (with embedded HPs from previous zones) and an adjacent zone in the direction of progression. Determination of the optimal Hamiltonin paths for subsequent zones has the effect of filtering out non-optimal Hamiltonian paths from earlier zones. |
| FILED | Monday, September 29, 2008 |
| APPL NO | 12/287157 |
| ART UNIT | 2129 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Artificial intelligence 76/45 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073804 | Rubin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Stuart Harvey Rubin (San Diego, California) |
| ABSTRACT | A KASER (Knowledge Amplification by Structured Expert Randomization) engine reaches conclusions in a semantic format or which take the form of a series of rules. The conclusions are parsed into an array structure having a hierarchical order of validity. A set of inserted rules is received as an initial rules array and are configured so that an antecedent comprises a non-empty, sorted set and a consequent comprises a non-empty sequence. A hierarchy of validity for the rules is determined and the rules are sorted according to the hierarchy. At least one rule set which optimizes the selection of rules is determined, with the rule set meeting predetermined validity requirements, and the rules are ordered in an order of validity, such as an order based on a maximal length antecedent set as a highest rank. |
| FILED | Monday, February 23, 2009 |
| APPL NO | 12/390633 |
| ART UNIT | 2129 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Artificial intelligence 76/48 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US H2265 | Fouse et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Timothy M. Fouse (Colonial Beach, Virginia); Michael M. Canaday (King George, Virginia); Steven W. Mundell (Richmond, Vermont); John R. Bowen, Jr. (Warsaw, Virginia); Michael John Hamel (Essex Junction, Vermont) |
| ABSTRACT | A differential variable reluctance transducer (DVRT) is provided to measure a translation parameter, such as acceleration and/or deceleration of a test projectile. The DVRT, contained in a canister of the projectile, includes a cylindrical housing and an electronics module. The housing defines a cavity containing insulation and a bobbin around which a wire coil is wrapped. The housing has an attachment end and a distal end that faces the acceleration indicator. The bobbin is disposed substantially collinear to the housing. The wire coil is helically disposed around the bobbin. The insulation fills the remainder of the cavity. The electronics module receives electric current from the wire coil and connects to a data recorder. |
| FILED | Wednesday, May 16, 2007 |
| APPL NO | 11/805264 |
| ART UNIT | 3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Measuring and testing 073/167 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US RE42999 | LeClerc et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Transpacific Kodex, LLC (Wilmington, Delaware) |
| INVENTOR(S) | Yvan G. LeClerc (Fremont, California); Margaret Frances Davies, legal representative (Palo Alto, California); Quang-Tuan Luong (San Jose, California); Pascal Fua (Lausanne, Switzerland) |
| ABSTRACT | The present invention provides a method for measuring the self-consistency of inference algorithms. The present invention provides a method for measuring the accuracy of an inference algorithm that does not require comparison to ground truth. Rather, the present invention pertains to a method for measuring the accuracy of an inference algorithm by comparing the outputs of the inference algorithm against each other. Essentially, the present invention looks at how well the algorithm applied to many of the different observations gives the same answer. In particular, the present invention provides a method that is not time and labor intensive and is cost effective. |
| FILED | Thursday, December 21, 2006 |
| APPL NO | 11/645331 |
| ART UNIT | 2624 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/170 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US RE43000 | Gaur et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | City of Hope (Duarte, California) |
| INVENTOR(S) | Rajesh K. Gaur (Glendora, California); Sailesh Gopalakrishna Pillai (Azusa, California) |
| ABSTRACT | The present invention relates to riboswitches that have been engineered to regulate pre-mRNA splicing. In particular, the insertion of a high affinity theophylline binding aptamer into the 3′ splice site region, 5′ splice site region, or branchpoint sequence (BPS) of a pre-mRNA modulates RNA splicing in the presence of theophylline. Accordingly, the aspects of the present invention include, but are not limited to, theophylline-dependent riboswitches which modulate RNA splicing, methods of modulating RNA splicing using theophylline and its corresponding riboswitches, methods of improving/identifying theophylline-dependent riboswitches, methods of treating diseases associated with or caused by abnormal RNA splicing. |
| FILED | Thursday, May 06, 2010 |
| APPL NO | 12/775422 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/91.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Health and Human Services (HHS)
| US 08069735 | Egorov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Artann Laboratories Inc. (Trenton, New Jersey) |
| INVENTOR(S) | Vladimir Egorov (Princeton, New Jersey); Armen P. Sarvazyan (Lambertville, New Jersey); Milind Patel (Bensalem, Pennsylvania) |
| ABSTRACT | A tactile sensor array includes a first electrode layer and a second electrode layer with a two-phase compressible dielectric material therebetween. A ferroelectret film is used as a dielectric layer. In some embodiments, to improve sensor sensitivity and at the same time provide for high stability and reproducibility of sensor readings, the ferroelectret film is vented to atmosphere via a venting network of channels traversing at least one electrode layer and a curved rigid substrate. In some embodiments, an elastic supporting structure is provided that comprises individual elastic fastening elements connecting all layers of the sensor together. These individual elastic fastening elements are located throughout the layers of the sensor and prevent cross-talk between the individual sensors that may be caused by local shifts of parts of the sensor during use. |
| FILED | Wednesday, November 10, 2010 |
| APPL NO | 12/943296 |
| ART UNIT | 3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Measuring and testing 073/862.46 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08069947 | Quasney et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Judit A. Quasney (Silver Spring, Maryland); Franklin Koh (Potomac, Maryland); John P. Jenkins (Frederick, Maryland); Robert M. Alexander (Mount Airy, Maryland); Daniel P. O'Brien (Boonsboro, Maryland) |
| ABSTRACT | A sound attenuation canopy for reducing levels of sound passing through an opening comprises a sound absorbing member. The sound absorbing member is comprised of a flexible sound absorbing material and has a first end, a second end and an intermediate portion extending between the first end and the second end. The first end is configured to attach to a periphery of the opening at a first location, the second end is configured to attach to a periphery of the opening at a second location and the intermediate portion is configured to be spaced apart from the opening. When the first end and the second end of the sound absorbing member are attached to the periphery of the opening, at least one side opening is at least partially defined by the intermediate portion and the perimeter of the opening, and a sound transmission flow path through open space between the opening and the side opening comprises at least one change of direction greater than 45 degrees. |
| FILED | Wednesday, April 21, 2010 |
| APPL NO | 12/764872 |
| ART UNIT | 2832 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Acoustics 181/224 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070682 | Zhu |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The University of Connecticut (Farmington, Connecticut) |
| INVENTOR(S) | Quing Zhu (Mansfield Center, Connecticut) |
| ABSTRACT | Methods and apparatus for medical imaging using diffusive optical tomography and fluorescent diffusive optical tomography and ultrasound are disclosed. In one embodiment, the probe comprises emitters and detectors that are inclined at an angle of about 1 to about 30 degrees to a surface of the probe that contacts tissue. In another embodiment, the scanned volume is divided into an inclusion region and a background region. Different voxel sizes are used in the inclusion region and the background region. Appropriate algorithms facilitate a reconstruction of the inclusion region to determine structural and functional features of the inclusion. |
| FILED | Thursday, July 19, 2007 |
| APPL NO | 11/780200 |
| ART UNIT | 3777 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Surgery 6/437 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071056 | Burns et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Mark A. Burns (Ann Arbor, Michigan); Brian N. Johnson (Ann Arbor, Michigan); Michael Chen (Singapore, Singapore) |
| ABSTRACT | The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device. |
| FILED | Friday, April 29, 2005 |
| APPL NO | 11/119539 |
| ART UNIT | 1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing 422/537 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071074 | Nadel et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jay A. Nadel (San Francisco, California); Kiyoshi Takeyama (Tokyo, Japan) |
| ABSTRACT | Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks the EGF receptor. The EGF-R antagonist is preferably administered by injection in an amount sufficient to inhibit formation of goblet cells in pulmonary airways. The degranulation of goblet cells that results in airway mucus production is thereby inhibited. Assays for screening candidate agents that inhibit goblet cell proliferation are also provided. |
| FILED | Wednesday, February 27, 2008 |
| APPL NO | 12/038718 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/46 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071082 | Zugates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Gregory T. Zugates (Cambridge, Massachusetts); Andreas Zumbuehl (Bern, Switzerland); Robert S. Langer (Newton, Massachusetts); Daniel G. Anderson (Sudbury, Massachusetts) |
| ABSTRACT | Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers. |
| FILED | Friday, July 20, 2007 |
| APPL NO | 11/780754 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/78.370 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071084 | Kopecko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Dennis J. Kopecko (Silver Spring, Maryland); De-Qi Xu (Columbia, Maryland); John O. Cisar (Gaithersburg, Maryland) |
| ABSTRACT | Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis. |
| FILED | Thursday, May 28, 2009 |
| APPL NO | 12/474223 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071100 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Unites States of America as represented by the Secretary of Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Zhaochun Chen (North Potomac, Maryland); Robert H. Purcell (Gaithersburgh, Maryland); Suzanne U. Emerson (Gaithersburgh, Maryland); Stephen H. Leppla (Bethesda, Maryland); Mahtab Moayeri (Bethesda, Maryland) |
| ABSTRACT | The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. |
| FILED | Thursday, February 21, 2008 |
| APPL NO | 12/528427 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/150.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071104 | Garen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Alan Garen (New Haven, Connecticut); Zhiwei Hu (New Haven, Connecticut) |
| ABSTRACT | Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The immunoconjugates typically consist of the Fc region of a human IgG1 immunoglobulin including the hinge, or other effector domain or domains that can elicit, when administered to a patient, a cytolytic immune response or cytotoxic effect against a targeted cell. The effector domain is conjugated to a targeting domain which comprises a factor VII mutant that binds with high affinity and specificity to tissue factor but does not initiate blood clotting such as factor VII having a substitution of alanine for lysine-341 or of alanine for serine-344. |
| FILED | Thursday, December 23, 2010 |
| APPL NO | 12/977937 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/182.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071109 | Norris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Steven J. Norris (Houston, Texas); Jing-Ren Zhang (Delmar, New York); John M. Hardham (Gales Ferry, Connecticut); Jerrilyn K. Howell (Houston, Texas); Alan G. Barbour (Newport Beach, California); George M. Weinstock (Houston, Texas) |
| ABSTRACT | The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies. |
| FILED | Monday, August 09, 2010 |
| APPL NO | 12/853019 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/234.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071113 | Kopecko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Dennis J. Kopecko (Silver Spring, Maryland); DeQi Xu (Columbia, Maryland) |
| ABSTRACT | The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making. |
| FILED | Tuesday, May 24, 2005 |
| APPL NO | 11/597301 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/258.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071210 | Lynn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wiscousin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | David M. Lynn (Middleton, Wisconsin); Maren E. Buck (Fitchburg, Wisconsin); Jingtao Zhang (Lansdale, Pennsylvania) |
| ABSTRACT | In one aspect, described herein are ultrathin films comprising an azlactone functionalized polymer and a primary amine functionalized polymer. Also described herein are ultrathin films including reactive, nonreactive, partially reactive/nonreactive, hydrophobic, hydrophilic, and mixed hydrophobic/hydrophilic ultrathin films. In another aspect, described herein are methods for making surface attached and freestanding ultrathin films. |
| FILED | Thursday, October 09, 2008 |
| APPL NO | 12/248788 |
| ART UNIT | 1762 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Stock material or miscellaneous articles 428/336 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071290 | Baylin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Johns Hopkins University School of Medicine (Baltimore, Maryland) |
| INVENTOR(S) | Stephen B. Baylin (Baltimore, Maryland); Yoshimitsu Akiyama (Chiba, Japan); James G. Herman (Lutherville, Maryland) |
| ABSTRACT | Methods are provided for identifying the presence of cancer cells in a sample by detecting hypermethylation of the promoter region of a GATA-4 transcription factor gene, a GATA-5 transcription factor gene, or both. Methods for ameliorating a cancer by effecting expression of a hypermethylation silenced GATA-4 and/or GATA-5 transcription also are provided. |
| FILED | Monday, May 12, 2008 |
| APPL NO | 12/119366 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071292 | Croce |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Ohio State University Research Foundation (Columbus, Ohio) |
| INVENTOR(S) | Carlo M. Croce (Columbus, Ohio) |
| ABSTRACT | The present invention provides methods and compositions for the diagnosis, prognosis and treatment of chronic lymphocytic leukemia (CLL). The invention also provides methods of identifying anti-CLL agents. |
| FILED | Monday, September 17, 2007 |
| APPL NO | 12/442018 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071293 | High et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Children's Hospital of Philadelphia (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Katherine A. High (Merion, Pennsylvania); Fayaz R. Khazi (Swedesboro, New Jersey); Kirk Chu (Narberth, Pennsylvania); Luca Monaldini (Turate, Italy); Mustafa Naci Yazicioglu (Drexel Hill, Pennsylvania); Samuel Murphy (Philadelphia, Pennsylvania) |
| ABSTRACT | Compositions and methods for detecting PRRG4- and PRRG2 associated molecules are provided as are methods of use thereof for the detection and treatment of cancer. |
| FILED | Monday, June 08, 2009 |
| APPL NO | 12/480426 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071304 | Brant et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Steven R. Brant (Reisterstown, Maryland); Amir Karban (Baltimore, Maryland); Franklin Nouvet (Laurel, Maryland); Theodore M. Bayless (Baltimore, Maryland); James J. Potter (Baltimore, Maryland); Esteban Mezey (Baltimore, Maryland); Toshihiko Okazaki (Baltimore, Maryland) |
| ABSTRACT | The present invention discloses a functional relationship between a recognized disease condition and a polymorphism in the nucleotide factor kappa B promoter (NFKB1). This relationship provides a platform for methods of altering promoter activity and for determining similar relationships between specific pathologies and identified polymorphisms. A statistically significant risk of developing ulcerative colitis was shown to be correlated with the presence of an ATTG insertion/deletion in the NFKB1 promoter and is likely to apply also to a variety of other inflammatory diseases. |
| FILED | Monday, April 05, 2004 |
| APPL NO | 10/818037 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.110 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071315 | Reed et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sanford-Burnham Medical Research Institute (La Jolla, California) |
| INVENTOR(S) | John C. Reed (Rancho Santa Fe, California); Maryla Krajewska (Oceanside, California) |
| ABSTRACT | Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast cancer, prostate cancer, lung cancer, or gastric cancer. |
| FILED | Thursday, April 30, 2009 |
| APPL NO | 12/433481 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071323 | Dimitrov et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Dimiter S. Dimitrov (Frederick, Maryland); Zhongyu Zhu (Frederick, Maryland) |
| ABSTRACT | Antibody compositions and methods for treatment of neoplastic disease in a mammalian subject are provided. Methods of diagnosing cancer in a mammalian subject are also provided. |
| FILED | Friday, April 06, 2007 |
| APPL NO | 12/296328 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.230 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071327 | Reed et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sanford-Burnham Medical Research Institute (La Jolla, California) |
| INVENTOR(S) | John C. Reed (Rancho Santa Fe, California); Quinn Deveraux (San Diego, California); Guy S. Salvesen (Encinitas, California); Ryosuke Takahashi (Kokubunji, Japan); Natalie Roy (La Jolla, California) |
| ABSTRACT | The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive ex vivo by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells. |
| FILED | Monday, August 02, 2010 |
| APPL NO | 12/848936 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/18 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071344 | Schultz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Peter G. Schultz (La Jolla, California); Lei Wang (San Diego, California) |
| ABSTRACT | Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs. |
| FILED | Friday, October 26, 2007 |
| APPL NO | 11/978182 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/183 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071346 | Eid et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Pacific Bioscience of California, Inc. (Menlo Park, California) |
| INVENTOR(S) | John Eid (Palo Alto, California); Devon Murphy (Mountain View, California); Geoffrey Otto (Santa Clara, California); Stephen Turner (Menlo Park, California) |
| ABSTRACT | Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period. |
| FILED | Wednesday, October 31, 2007 |
| APPL NO | 11/981626 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/188 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071348 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Albert Einstein College of Medicine of Yeshiva University (Bronx, New York) |
| INVENTOR(S) | Zhong-Yin Zhang (Scarsdale, New York); Laiping Xie (Bronx, New York); Yan-Ling Zhang (Belmont, Massachusetts) |
| ABSTRACT | The present invention provides protein tyrosine phosphatases (PTP) in which the invariant aspartate residue and the invariant glutamine residue are each replaced with a replacement amino acid residue, wherein the replacement residues together cause a reduction in catalytic rate (kcat) of the enzyme and an increase in substrate-binding affinity (Kd) of the enzyme. The present invention further provides methods for identifying a substrate of a PTP. Also provided are kits for identifying a substrate of a PTP. Additionally, the present invention provides methods for identifying an agent that alters interaction between a PTP and a substrate of the PTP. The invention also provides methods for reducing the activity of a substrate of a PTP. |
| FILED | Friday, January 10, 2003 |
| APPL NO | 10/340288 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/196 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071369 | Jaenisch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| INVENTOR(S) | Rudolf Jaenisch (Brookline, Massachusetts); Konrad Hochedlinger (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state. |
| FILED | Tuesday, February 09, 2010 |
| APPL NO | 12/703015 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/325 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071377 | Bernstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | Irwin D. Bernstein (Seattle, Washington); Barbara Varnum-Finney (Seattle, Washington) |
| ABSTRACT | The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that support the proliferation but not differentiation of the non-terminally differentiated cells. The present invention further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the invention can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs. The invention further provides a cell culture comprising a population of non-terminally differentiated cells immortalized by the methods of the present invention and kits comprising reagents that promote the immortalization of precursor cells. The invention further provides methods for screening for Notch modulators and for identifying genes involved in processes of cellular differentiation. |
| FILED | Tuesday, July 15, 2008 |
| APPL NO | 12/173185 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/377 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071381 | Elson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Washington University in St. Louis (St. Louis, Missouri) |
| INVENTOR(S) | Elliot Elson (University City, Missouri); William B. McConnaughey (St. Louis, Missouri); Tetsuro Wakatsuki (Milwaukee, Wisconsin) |
| ABSTRACT | A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and tissue stiffness. A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and hysteresis. |
| FILED | Tuesday, November 11, 2008 |
| APPL NO | 12/268783 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/383 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071395 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Ronald W. Davis (Palo Alto, California); Stefanie S. Jeffrey (Los Altos Hills, California); Michael N. Mindrinos (Menlo Park, California); R. Fabian Pease (Stanford, California); Ashley Ann Powell (Mountain View, California); AmirAli Hajhossein Talasaz (Los Altos, California) |
| ABSTRACT | Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput. |
| FILED | Thursday, December 11, 2008 |
| APPL NO | 12/333213 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/524 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071540 | Montelaro et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Ronald C. Montelaro (Wexford, Pennsylvania); Timothy A. Mietzner (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The antimicrobial peptides are monomers or multimers of peptides referred to as the Lytic Base Unit (LBU) peptides, derived from the LLP1 analogs and also having antimicrobial activity. Also described herein are using the peptides in a variety of contexts, including the treatment or prevention of infectious diseases. Methods of killing fungi, such as Candida and Cryptococcus species, and bacteria, such as B. anthracis, are provided herein. Methods of neutralizing enveloped viruses, such as poxvirus, herpesvirus, rhabdovirus, hepadnavirus, baculovirus, orthomyxovirus, paramyxovirus, retrovirus, togavirus, bunyavirus and flavivirus, including influenza virus and HIV-1 also are provided herein. Solid phase substrates and peptide-cargo complexes comprising the peptides also are provided. |
| FILED | Friday, July 11, 2008 |
| APPL NO | 12/171806 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/2.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071541 | Arora et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Aileron Therapeutics, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Paramjit Arora (New York, New York); Ross Chapman (New York, New York) |
| ABSTRACT | The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 310-helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, 310-helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed. |
| FILED | Wednesday, February 24, 2010 |
| APPL NO | 12/712089 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/2.900 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071546 | Cabrales et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | La Jolla Bioengineering Institute (La Jolla, California); Albert Einstein College of Medicine of Yeshiva University (Bronx, New York) |
| INVENTOR(S) | Pedro Cabrales (San Diego, California); Amy Tsai (San Diego, California); Seetharama A. Acharya (Cresskill, New Jersey); Belur N. Manjula (Cresskill, New Jersey) |
| ABSTRACT | The present invention is directed to uses of PEGylated albumins which include methods of treating reduced functional capillary density, reduced blood volume, septic shock and cardiac arrhythmia in a subject, which comprise administering to the subject a therapeutically effective amount of a PEGylated albumin. |
| FILED | Friday, June 09, 2006 |
| APPL NO | 11/921689 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/12 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071553 | Hefeneider et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of American as represented by the Department of Veterans Affairs (Washington, District of Columbia); Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | Steven H. Hefeneider (Portland, Oregon); Sharon L. McCoy (Portland, Oregon) |
| ABSTRACT | Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used as therapy to reduce and/or inhibit, or initiate and/or enhance, an inflammatory response in a subject. |
| FILED | Friday, June 05, 2009 |
| APPL NO | 12/479645 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/21.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071573 | Sanders et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois, a Body Corporate and Politic of the State of Illinois (Urbana, Illinois) |
| INVENTOR(S) | John M. Sanders (Collegeville, Pennsylvania); Yongcheng Song (Pearland, Texas); Julian M. W. Chan (Boston, Massachusetts); Eric Oldfield (Champaign, Illinois); Yonghui Zhang (Urbana, Illinois) |
| ABSTRACT | Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy. |
| FILED | Monday, June 28, 2010 |
| APPL NO | 12/825218 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/89 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071645 | Newell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of Colorado (Denver, Colorado) |
| INVENTOR(S) | M. Karen Newell (Colorado Springs, Colorado); Evan Newell (Toronto, Canada); Elizabeth Villalobos-Menuey (Colorado Springs, Colorado) |
| ABSTRACT | Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherpeutic agents. In preferred embodiments, the invention combines an oxirane carboxylic acid, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and/or an antibody against UCP and/or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers. |
| FILED | Friday, June 11, 2004 |
| APPL NO | 10/866141 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/557 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071722 | Kaplan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Hyoung-Joon Jin (Seoul, South Korea); Gregory Rutledge (Newton, Massachusetts); Sergey Fridrikh (Acton, Massachusetts) |
| ABSTRACT | The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo. |
| FILED | Friday, January 15, 2010 |
| APPL NO | 12/688014 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/353 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071742 | Kobilka et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Brian Kobilka (Palo Alto, California); Daniel Rosenbaum (Burlingame, California) |
| ABSTRACT | Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR. |
| FILED | Wednesday, February 16, 2011 |
| APPL NO | 12/932075 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Organic compounds 536/23.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071743 | Zuker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Charles S. Zuker (San Diego, California); Jon Elliot Adler (Pacific Beach, California); Juergen Lindemeier (Werl, Germany) |
| ABSTRACT | The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors. |
| FILED | Friday, December 03, 2010 |
| APPL NO | 12/960409 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Organic compounds 536/23.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071744 | Kaper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Carnegie Institution of Washington (Washington, District of Columbia); The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Thijs Kaper (Palo Alto, California); Michael Platten (Dossenheim, Germany); Lawrence Steinman (Stanford, California); Wolf Frommer (Stanford, California) |
| ABSTRACT | The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression. |
| FILED | Thursday, April 28, 2011 |
| APPL NO | 13/096643 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Organic compounds 536/23.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071746 | Remaley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Alan T. Remaley (Bethesda, Maryland); Stephen J. Demosky (Gaithersburg, Maryland); John A. Stonik (Gaithersburg, Maryland); Marcele J. A. Amar (Gaithersburg, Maryland); Edward B. Neufeld (Washington, District of Columbia); Bryan H. Brewer (Potomac, Maryland); Fairwell Thomas (Rockville, Maryland) |
| ABSTRACT | Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein. |
| FILED | Thursday, July 02, 2009 |
| APPL NO | 12/497443 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Organic compounds 536/23.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071751 | Delwart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Blood Systems, Inc. (Scottsdale, Arizona) |
| INVENTOR(S) | Eric Delwart (San Francisco, California); Amit Kapoor (Pacifica, California) |
| ABSTRACT | Provided herein are sequences of the genomes and encoded proteins of a new human parvovirus, Bocavirus-2, and variants thereof. Also provided are methods of detecting the Bocavirus-2 and diagnosing Bocavirus-2 infection, methods of treating or preventing Bocavirus-2 infection, and methods for identifying anti-Bocavirus-2 compounds. |
| FILED | Friday, April 17, 2009 |
| APPL NO | 12/426173 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Organic compounds 536/24.320 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071752 | Rossi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | City of Hope (Duarte, California) |
| INVENTOR(S) | John J. Rossi (Alta Loma, California); Ola Snove, Jr. (Oslo, Norway); Ali Ehsani (West Covina, California); Pal Saetrom, Jr. (Trondheim, Norway); Britta Hoehn (Hagen, Germany); Jane Zhang (South El Monte, California); Lars Aagaard (Ry, Denmark) |
| ABSTRACT | The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets. |
| FILED | Tuesday, January 29, 2008 |
| APPL NO | 12/021604 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/24.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071759 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Affymetrix, Inc. (Santa Clara, California) |
| INVENTOR(S) | Lijun Huang (Waterville, Ohio); Benjamin R. Travis (Maumee, Ohio) |
| ABSTRACT | Four novel water soluble cholesterol derivative compounds are disclosed. These compounds have various applications in studies of membrane proteins, including drug screening and studies of receptor stability and folding. In one aspect the water soluble cholesterol derivatives disclosed may be used to replace cholesterol in micelle-solubilized membrane protein preparations. |
| FILED | Monday, June 29, 2009 |
| APPL NO | 12/494159 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Organic compounds 536/123.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071760 | Vicente et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Maria da Graça Henriques Vicente (Baton Rouge, Louisiana); Erhong Hao (Anhui, China PRC) |
| ABSTRACT | Boron-containing porphyrin compounds are disclosed that may be used for boron neutron capture therapy of tumors, radiotherapy of tumors, and photodynamic therapy of tumors. |
| FILED | Wednesday, October 25, 2006 |
| APPL NO | 12/091211 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Organic compounds 540/145 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071761 | Tsien et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Roger Y. Tsien (La Jolla, California); Gregor Zlokarnik (La Jolla, California) |
| ABSTRACT | Substrates for β-lactamase of the general formula I in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which may or may not re-emit); R′ is selected from the group consisting of H, lower (i.e., alkyl of 1 to about 5 carbon atoms) and (CH2)nOH, in which n is 0 or an integer from 1 to 5; R″ is selected from the group consisting of H, physiologically acceptable metal and ammonium cations, —CHR2OCO(CH2)nCH3, —CHR2OCOC (CH3)3, acylthiomethyl, acyloxy-alpha-benzyl, delta-butyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, beta-morpholinoethyl, dialkylaminoethyl, acyloxyalkyl, dialkylaminocarbonyloxymethyl and aliphatic, in which R2 is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO2 and CH2; and Z′ and Z″ are linkers for the fluorescent donor and quencher moieties. Methods of assaying β-lactamase activity and monitoring expression in systems using β-lactamase as a reporter gene also are disclosed. |
| FILED | Wednesday, November 29, 2006 |
| APPL NO | 11/606642 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Organic compounds 540/222 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071786 | Sard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Galenea Corp. (Cambridge, Massachusetts) |
| INVENTOR(S) | Howard P. Sard (Arlington, Massachusetts); Louis Shuster (Brighton, Massachusetts); Bryan Roth (Moreland Hills, Ohio); Cynthia Morency (Andover, Massachusetts); Govindaraj Kumaran (Woburn, Massachusetts); Liang Xu (Woburn, Massachusetts) |
| ABSTRACT | Novel indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds. |
| FILED | Monday, December 14, 2009 |
| APPL NO | 12/637600 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Organic compounds 548/506 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071789 | Tsien et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Roger Y. Tsien (La Jolla, California); B. Albert Griffin (Del Mar, California) |
| ABSTRACT | The present invention features biarsenical molecules. Target sequences that specifically react with the biarsenical molecules are also included. The present invention also features kits that include biarsenical molecules and target sequences. Tetraarsenical molecules are also featured in the invention. |
| FILED | Wednesday, March 18, 2009 |
| APPL NO | 12/406702 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Organic compounds 549/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071795 | Van Meir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia); Scripps Research Institute (LaJolla, California) |
| INVENTOR(S) | Erwin G Van Meir (Tucker, Georgia); Kyriacos Nicolaou (La Jolla, California) |
| ABSTRACT | HIF-1 inhibitors and methods of use thereof are provided. |
| FILED | Friday, August 25, 2006 |
| APPL NO | 11/997809 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Organic compounds 549/292 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071838 | Mumm et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Washington University in St. Louis (St. Louis, Missouri) |
| INVENTOR(S) | Jeffrey S. Mumm (Augusta, Georgia); Eric H. Schroeter (Pleasant Prairie, Wisconsin) |
| ABSTRACT | A system including: (i) a methodology for targeted cellular ablation in zebrafish; (ii) a methodology for regional cellular ablation in zebrafish. These methodologies are used to identify genetic components that regulate cellular regeneration and to identify drug compounds that influence cellular regeneration for the purpose of developing therapies for degenerative conditions. Transgenic zebrafish disclosed herein contain transgenic constructs composed of: (i) cell and/or tissue-type specific regulatory elements (e.g. promoter and/or enhancer regions) which delimit expression of operably linked gene product(s) to discrete cellular populations; (ii) a gene product that promotes cellular ablation composed of a pro-drug conversion system capable of converting nontoxic pro-drugs into cytotoxic drugs, which is expressed alone or in connection with; (iii) a reporter gene product that allows selective detection of cells expressing the reporter—both prior to (initial cells) and following cellular ablation (regenerated cells). Here we describe genetic delivery of a pro-drug converting system in order to enable targeted cellular ablation in zebrafish, Transgenic zebrafish of this invention provide a high-throughput system for genetic dissection of the process of cellular regeneration and, compound screening for the discovery of drugs capable of promoting cellular regeneration. |
| FILED | Friday, February 27, 2009 |
| APPL NO | 12/394740 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Multicellular living organisms and unmodified parts thereof and related processes 8/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072214 | Chamberlain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Regents of the University of Minnesota (St. Paul, Minnesota) |
| INVENTOR(S) | Ryan Chamberlain (New Brighton, Minnesota); Jang-Yeon Park (Minneapolis, Minnesota); Michael G. Garwood (Medina, Minnesota) |
| ABSTRACT | A method of magnetic resonance imaging based on rapid acquisition by sequential excitation and refocusing is provided. The method comprises turning on a first time-encoding gradient and applying an excitation pulse in the presence of the first time-encoding gradient. The excitation pulse excites magnetization sequentially along one spatial axis. Thereafter, a first refocusing pulse is applied. A second time-encoding gradient is turned on followed by a second refocusing pulse. A third time-encoding gradient is turned on and a signal is acquired in the presence of the third time-encoding gradient. The third time-encoding gradient sums to zero with the first time-encoding gradient and the second time-encoding gradient for sequential points in space. |
| FILED | Monday, August 16, 2010 |
| APPL NO | 12/857370 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/309 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072216 | Ehman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Richard L. Ehman (Rochester, Minnesota); Meng Yin (Rochester, Minnesota); Kevin J. Glaser (Rochester, Minnesota) |
| ABSTRACT | A system is configured to produce a stress on a subject while performing a magnetic resonance elastography scan in a magnetic resonance imaging (MRI) system. The system includes an active driver operable to produce an energy configured for a magnetic resonance elastography (MRE) process. A passive actuator is configured to be positioned in the MRI system and to be coupled to the subject. The system includes a tube coupling the active driver to the passive actuator to deliver the energy produced by the active driver to the passive actuator, and a strap coupled to the passive actuator. The strap is configured to be disposed around the subject. The strap includes a substantially inelastic material configured to convert the energy delivered to the passive actuator from the tube into shear waves with the subject for use in the MRE process. |
| FILED | Friday, April 03, 2009 |
| APPL NO | 12/418218 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/318 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073167 | Miles |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Research Foundation of State University of New York (Binghamton, New York) |
| INVENTOR(S) | Ronald Miles (Newark Valley, New York) |
| ABSTRACT | A miniature microphone, comprising a diaphragm, supported for displacement in response to acoustic waves, from which a plurality of projections extend; a plurality of projections extending from a surface; a body, supporting the surface to maintain the plurality of projections from the diaphragm and the plurality of projections from the surface in close proximity; and an electromagnetic sensor adapted to sense an electromagnetic interaction between the plurality of projections from the diaphragm and the plurality of projections from the surface and produce an electrical signal in response thereto. The interaction may be detected substantially without inducing a force which tends to substantially displace the diaphragm, since the electrostatic force is substantially parallel to the diaphragm surface. |
| FILED | Tuesday, June 09, 2009 |
| APPL NO | 12/481131 |
| ART UNIT | 2614 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Electrical audio signal processing systems and devices 381/174 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073210 | Reinhardt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of lowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Joseph Reinhardt (Iowa City, Iowa); Milan Sonka (Coralville, Iowa); Geoffrey McLennan (Iowa City, Iowa); Eric Hoffman (Iowa City, Iowa); Soumik Ukil (Iowa City, Iowa) |
| ABSTRACT | Automated methods for segmenting and smoothing volumes of interest, such as the mediastinal boundary of a lung. Devices and systems configured to perform the automated methods. |
| FILED | Tuesday, February 14, 2006 |
| APPL NO | 11/355321 |
| ART UNIT | 2624 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/128 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073216 | Dawant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Benoit M. Dawant (Nashville, Tennessee); Jack H. Noble (Nashville, Tennessee) |
| ABSTRACT | A system and method for automatic segmentation of a structure of interest of an ear are disclosed, where the structure of interest includes the facial nerve and chorda tympani. In one embodiment, the method combines an atlas-based approach with a minimum cost path finding algorithm. A structure model is constructed from a plurality of preoperative image volumes to have a centerline of the structure of interest in an atlas with each point along the centerline being associated with expected values for characteristic features, and used to create a spatially varying cost function that includes geometric information. A three-dimension minimum cost accumulating path is computed using the cost function, which is used to extract the centerline of the structure of interest. The centerlines are then expanded into the full structures using a level-set algorithm with a spatially-varying speed function, so as to segment of the structure of interest. |
| FILED | Thursday, August 28, 2008 |
| APPL NO | 12/200075 |
| ART UNIT | 2862 — Printing/Measuring and Testing |
| CURRENT CPC | Image analysis 382/128 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073549 | Chen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | Wei Chen (Tampa, Florida) |
| ABSTRACT | Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. Na/K pump molecules were used as an example in a physiological operating mode by applying the concept of an electronic synchrotron to the biological system. It was shown that individual Na/K pump molecules can be synchronized by a well designed oscillating electric field. The synchronized pump currents show separated inward and outward pump currents and a magnitude ratio of 3:2 reflecting stoichiometric number of the pump molecules. |
| FILED | Monday, April 19, 2010 |
| APPL NO | 12/762708 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Surgery: Light, thermal, and electrical application 67/76 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US RE43000 | Gaur et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | City of Hope (Duarte, California) |
| INVENTOR(S) | Rajesh K. Gaur (Glendora, California); Sailesh Gopalakrishna Pillai (Azusa, California) |
| ABSTRACT | The present invention relates to riboswitches that have been engineered to regulate pre-mRNA splicing. In particular, the insertion of a high affinity theophylline binding aptamer into the 3′ splice site region, 5′ splice site region, or branchpoint sequence (BPS) of a pre-mRNA modulates RNA splicing in the presence of theophylline. Accordingly, the aspects of the present invention include, but are not limited to, theophylline-dependent riboswitches which modulate RNA splicing, methods of modulating RNA splicing using theophylline and its corresponding riboswitches, methods of improving/identifying theophylline-dependent riboswitches, methods of treating diseases associated with or caused by abnormal RNA splicing. |
| FILED | Thursday, May 06, 2010 |
| APPL NO | 12/775422 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/91.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 08069703 | Granite et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the United States Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Evan J. Granite (Wexford, Pennsylvania); Henry W. Pennline (Bethel Park, Pennsylvania) |
| ABSTRACT | A new method for the semi-continuous detection of heavy metals and metalloids including mercury in gaseous streams. The method entails mass measurement of heavy metal oxides and metalloid oxides with a surface acoustic wave (SAW) sensor having an uncoated substrate. An array of surface acoustic wave (SAW) sensors can be used where each sensor is for the semi-continuous emission monitoring of a particular heavy metal or metalloid. |
| FILED | Friday, November 30, 2007 |
| APPL NO | 11/947815 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/24.10 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070425 | Roberts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Honeywell International Inc. (Morristown, New Jersey) |
| INVENTOR(S) | Quentin Roberts (Nancy, France); Ahmed Alnega (Thaon Les Vosges, France) |
| ABSTRACT | A turbocharger having a sliding piston for regulating exhaust gas flow into the turbine wheel includes a set of first vanes mounted on a fixed first wall of the turbine nozzle and projecting axially toward an opposite second wall of the nozzle, and/or a set of second vanes mounted on the end of the piston and projecting in an opposite axial direction toward the first wall of the nozzle. For the/each set of vanes, there are leakage dams formed on the wall that is adjacent the vane tips when the piston is closed. The leakage dams are closely adjacent the vane tips and discourage exhaust gas from leaking in a generally radial direction past the vane tips as the piston just begins to open from its fully closed position. |
| FILED | Friday, March 28, 2008 |
| APPL NO | 12/058052 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Rotary kinetic fluid motors or pumps 415/157 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070840 | Diaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Shell Oil Company (Houston, Texas) |
| INVENTOR(S) | Zaida Diaz (Katy, Texas); Alan Anthony Del Paggio (Spring, Texas); Vijay Nair (Katy, Texas); Augustinus Wilhelmus Maria Roes (Houston, Texas) |
| ABSTRACT | A method of producing methane is described. The method includes providing formation fluid from a subsurface in situ conversion process. The formation fluid is separated to produce a liquid stream and a first gas stream. The first gas stream includes olefins. At least the olefins in the first gas stream are contacted with a hydrogen source in the presence of one or more catalysts and steam to produce a second gas stream. The second gas stream is contacted with a hydrogen source in the presence of one or more additional catalysts to produce a third gas stream. The third gas stream includes methane. |
| FILED | Friday, April 21, 2006 |
| APPL NO | 11/409524 |
| ART UNIT | 1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Gas: Heating and illuminating 048/197.R00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070860 | Vanderspurt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | United Technologies Corporation (East Hartford, Connecticut) |
| INVENTOR(S) | Thomas Henry Vanderspurt (Glastonbury, Connecticut); Ying She (Worcester, Massachusetts); Zissis Dardas (Worcester, Massachusetts); Craig Walker (South Glastonbury, Connecticut); James D. MacLeod (Vernon, Connecticut) |
| ABSTRACT | An H2-permeable membrane system (117) comprises an electroless-deposited plating (115) of Pd or Pd alloy on a porous support (110, 110′). The Pd plating comprises face-centered cubic crystals cumulatively having a morphology of hexagonal platelets. The permeability to H2 of the membrane plating (115) on the porous support is significantly enhanced, being at least greater than about 1.3×10−8 mol·m−1·s−·Pa−0.5 at 350° C., and even greater than about 3.4×10−8 mol·m−1·s−1·Pa−0.5. The porous support (110, 110′) may be stainless steel (1100 and include a thin ceramic interlayer (110′) on which the Pd is plated. The method of providing the electroless-deposited plating includes preheating a Pd electroless plating solution to near a plating temperature substantially greater than room temperature, e.g. 60° C., prior to plating. |
| FILED | Thursday, September 28, 2006 |
| APPL NO | 12/311294 |
| ART UNIT | 1776 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Gas separation: Apparatus 096/11 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070881 | Fox et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Energy Alliance (Idaho Falls, Idaho) |
| INVENTOR(S) | Robert V. Fox (Idaho Falls, Idaho); Recep Avci (Bozeman, Montana); Gary S. Groenewold (Idaho Falls, Idaho) |
| ABSTRACT | Methods of removing contaminant matter from porous materials include applying a polymer material to a contaminated surface, irradiating the contaminated surface to cause redistribution of contaminant matter, and removing at least a portion of the polymer material from the surface. Systems for decontaminating a contaminated structure comprising porous material include a radiation device configured to emit electromagnetic radiation toward a surface of a structure, and at least one spray device configured to apply a capture material onto the surface of the structure. Polymer materials that can be used in such methods and systems include polyphosphazine-based polymer materials having polyphosphazine backbone segments and side chain groups that include selected functional groups. The selected functional groups may include iminos, oximes, carboxylates, sulfonates, β-diketones, phosphine sulfides, phosphates, phosphites, phosphonates, phosphinates, phosphine oxides, monothio phosphinic acids, and dithio phosphinic acids. |
| FILED | Thursday, February 11, 2010 |
| APPL NO | 12/704409 |
| ART UNIT | 1762 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Cleaning and liquid contact with solids 134/1 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070987 | Lynn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Washington State University Research Foundation (Pullman, Washington) |
| INVENTOR(S) | Kelvin Lynn (Pullman, Washington); Kelly Jones (Colfax, Washington); Guido Ciampi (Watertown, Massachusetts) |
| ABSTRACT | Semiconductor materials suitable for being used in radiation detectors are disclosed. A particular example of the semiconductor materials includes tellurium, cadmium, and zinc. Tellurium is in molar excess of cadmium and zinc. The example also includes aluminum having a concentration of about 10 to about 20,000 atomic parts per billion and erbium having a concentration of at least 10,000 atomic parts per billion. |
| FILED | Monday, March 05, 2007 |
| APPL NO | 11/910504 |
| ART UNIT | 1761 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Compositions 252/519.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071107 | Haynes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Duke University (Durham, North Carolina); The Regents of the University of California (Oakland, California); The University of Alabama at Birmingham Research Foundation (Birmingham, Alabama) |
| INVENTOR(S) | Barton F. Haynes (Durham, North Carolina); Feng Gao (Durham, North Carolina); Bette T. Korber (Los Alamos, New Mexico); Beatrice H. Hahn (Birmingham, Alabama); George M. Shaw (Birmingham, Alabama); Denise Kothe (Birmingham, Alabama); Ying Ying Li (Hoover, Alabama); Julie Decker (Alabaster, Alabama); Hua-Xin Liao (Chapel Hill, North Carolina) |
| ABSTRACT | The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens. |
| FILED | Friday, September 17, 2004 |
| APPL NO | 10/572638 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/208.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071164 | Dugger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sandia Corporation (Albuquerque, New Mexico) |
| INVENTOR(S) | Michael T. Dugger (Tijeras, New Mexico); James A. Ohlhausen (Albuquerque, New Mexico); David B. Asay (Boalsburg, Pennsylvania); Seong H. Kim (State College, Pennsylvania) |
| ABSTRACT | A method is provided for tribological lubrication of sliding contact surfaces, where two surfaces are in contact and in motion relative to each other, operating in a vapor-phase environment containing at least one alcohol compound at a concentration sufficiently high to provide one monolayer of coverage on at least one of the surfaces, where the alcohol compound continuously reacts at the surface to provide lubrication. |
| FILED | Wednesday, May 07, 2008 |
| APPL NO | 12/116243 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Coating processes 427/248.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071295 | Ashby |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Ashby (Mill Valley, California) |
| ABSTRACT | The present invention relates to methods for performing surveys of the genetic diversity of a population. The invention also relates to methods for performing genetic analyses of a population. The invention further relates to methods for the creation of databases comprising the survey information and the databases created by these methods. The invention also relates to methods for analyzing the information to correlate the presence of nucleic acid markers with desired parameters in a sample. These methods have application in the fields of geochemical exploration, agriculture, bioremediation, environmental analysis, clinical microbiology, forensic science and medicine. |
| FILED | Wednesday, June 25, 2003 |
| APPL NO | 10/607077 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071344 | Schultz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Peter G. Schultz (La Jolla, California); Lei Wang (San Diego, California) |
| ABSTRACT | Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs. |
| FILED | Friday, October 26, 2007 |
| APPL NO | 11/978182 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/183 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071349 | Dunn-Coleman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Danisco US Inc. (Palo Alto, California) |
| INVENTOR(S) | Nigel Dunn-Coleman (Los Gatos, California); Frits Goedegebuur (Vlaardingen, Netherlands); Michael Ward (San Francisco, California); Jian Yao (Sunnyvale, California) |
| ABSTRACT | The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl4, and the corresponding BGL4 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL4, recombinant BGL4 proteins and methods for producing the same. |
| FILED | Tuesday, November 13, 2007 |
| APPL NO | 11/938932 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071359 | Weiss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Shimon Weiss (Pinole, California); Marcel Bruchez (Newark, California); Paul Alivisatos (Oakland, California) |
| ABSTRACT | A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe. |
| FILED | Tuesday, December 05, 2006 |
| APPL NO | 11/566998 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/283.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071360 | Weiss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Shimon Weiss (Pinole, California); Marcel Bruchez (Newark, California); Paul Alivisatos (Oakland, California) |
| ABSTRACT | A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe. |
| FILED | Friday, March 20, 2009 |
| APPL NO | 12/408466 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/283.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071361 | Weiss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Shimon Weiss (Pinole, California); Marcel Bruchez (Newark, California); Paul Alivisatos (Oakland, California) |
| ABSTRACT | A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe. |
| FILED | Friday, February 26, 2010 |
| APPL NO | 12/714284 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/283.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071500 | Granite et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the United States Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Evan J. Granite (Wexford, Pennsylvania); Henry W. Pennline (Bethel Park, Pennsylvania) |
| ABSTRACT | A catalyst for the oxidation of heavy metal contaminants, especially mercury (Hg), in an effluent stream is presented. The catalyst facilitates removal of mercury through the oxidation of elemental Hg into mercury (II) moieties. The active component of the catalyst is partially combusted coal, or “Thief” carbon, which can be pre-treated with a halogen. An untreated Thief carbon catalyst can be self-promoting in the presence of an effluent gas streams entrained with a halogen. |
| FILED | Tuesday, July 13, 2010 |
| APPL NO | 12/835204 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Catalyst, solid sorbent, or support therefor: Product or process of making 52/180 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071504 | Ragle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Caterpillar Inc. (Peoria, Illinois) |
| INVENTOR(S) | Christie Susan Ragle (Havana, Illinois); Ronald G. Silver (Peoria, Illinois); Svetlana Mikhailovna Zemskova (Edelstein, Illinois); Colleen J. Eckstein (Metamora, Illinois) |
| ABSTRACT | A method of providing an exhaust treatment device is disclosed. The method includes applying a catalyst including gold and a platinum group metal to a particulate filter. The concentration of the gold and the platinum group metal is sufficient to enable oxidation of carbon monoxide and nitric oxide. |
| FILED | Friday, December 19, 2008 |
| APPL NO | 12/318002 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Catalyst, solid sorbent, or support therefor: Product or process of making 52/333 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071748 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | David N. Thompson (Idaho Falls, Idaho); William A. Apel (Jackson, Wyoming); Vicki S. Thompson (Idaho Falls, Idaho); David W. Reed (Idaho Falls, Idaho); Jeffrey A. Lacey (Idaho Falls, Idaho) |
| ABSTRACT | Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius. |
| FILED | Tuesday, April 19, 2011 |
| APPL NO | 13/066645 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Organic compounds 536/23.700 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071790 | Iyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Los Alamos National Security, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Rashi Iyer (Los Alamos, New Mexico); Kumkum Ganguly (Los Alamos, New Mexico); Louis A. Silks (Los Alamos, New Mexico) |
| ABSTRACT | Bacterial quorum-sensing molecule analogs having the following structures: and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic. |
| FILED | Tuesday, September 01, 2009 |
| APPL NO | 12/551994 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Organic compounds 549/69 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071813 | Pagoria et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Philip Pagoria (Livermore, California); Amitesh Maiti (San Ramon, California); Alexander Gash (Brentwood, California); Thomas Yong Han (Pleasanton, California); Christine Orme (Oakland, California); Laurence Fried (Livermore, California) |
| ABSTRACT | A method in one embodiment includes contacting a strongly hydrogen bonded organic material with an ionic liquid having a fluoride anion for solubilizing the strongly hydrogen bonded organic material; and maintaining the ionic liquid at a temperature of about 90° C. or less during the contacting. A method in another embodiment includes contacting a strongly hydrogen bonded organic material with an ionic liquid having an acetate or formate anion for solubilizing the strongly hydrogen bonded organic material; and maintaining the ionic liquid at a temperature of less than about 90° C. during the contacting. |
| FILED | Wednesday, April 23, 2008 |
| APPL NO | 12/108347 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Organic compounds 564/437 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071931 | Novack et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Steven D. Novack (Idaho Falls, Idaho); Dale K. Kotter (Shelley, Idaho); Patrick J. Pinhero (Columbia, Missouri) |
| ABSTRACT | Methods, devices and systems for harvesting energy from electromagnetic radiation are provided including harvesting energy from electromagnetic radiation. In one embodiment, a device includes a substrate and one or more resonance elements disposed in or on the substrate. The resonance elements are configured to have a resonant frequency, for example, in at least one of the infrared, near-infrared and visible light spectra. A layer of conductive material may be disposed over a portion of the substrate to form a ground plane. An optical resonance gap or stand-off layer may be formed between the resonance elements and the ground plane. The optical resonance gap extends a distance between the resonance elements and the layer of conductive material approximately one-quarter wavelength of a wavelength of the at least one resonance element's resonant frequency. At least one energy transfer element may be associated with the at least one resonance element. |
| FILED | Tuesday, November 13, 2007 |
| APPL NO | 11/939342 |
| ART UNIT | 2878 — Optics |
| CURRENT CPC | Radiant energy 250/208.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071945 | Krishna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | STC.UNM (Albuquerque, New Mexico); Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Sanjay Krishna (Albuquerque, New Mexico); Majeed M. Hayat (Albuquerque, New Mexico); J. Scott Tyo (Tucson, Arizona); Woo-Yong Jang (Albuquerque, New Mexico) |
| ABSTRACT | Exemplary embodiments provide an infrared (IR) retinal system and method for making and using the IR retinal system. The IR retinal system can include adaptive sensor elements, whose properties including, e.g., spectral response, signal-to-noise ratio, polarization, or amplitude can be tailored at pixel level by changing the applied bias voltage across the detector. “Color” imagery can be obtained from the IR retinal system by using a single focal plane array. The IR sensor elements can be spectrally, spatially and temporally adaptive using quantum-confined transitions in nanoscale quantum dots. The IR sensor elements can be used as building blocks of an infrared retina, similar to cones of human retina, and can be designed to work in the long-wave infrared portion of the electromagnetic spectrum ranging from about 8 μm to about 12 μm as well as the mid-wave portion ranging from about 3 μm to about 5 μm. |
| FILED | Friday, August 01, 2008 |
| APPL NO | 12/184491 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Radiant energy 250/338.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071949 | Majewski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Jefferson Science Associates, LLC (Newport News, Virginia) |
| INVENTOR(S) | Stanislaw Majewski (Yorktown, Virginia); James Proffitt (Newport News, Virginia) |
| ABSTRACT | A compact, mobile, dedicated SPECT brain imager that can be easily moved to the patient to provide in-situ imaging, especially when the patient cannot be moved to the Nuclear Medicine imaging center. As a result of the widespread availability of single photon labeled biomarkers, the SPECT brain imager can be used in many locations, including remote locations away from medical centers. The SPECT imager improves the detection of gamma emission from the patient's head and neck area with a large field of view. Two identical lightweight gamma imaging detector heads are mounted to a rotating gantry and precisely mechanically co-registered to each other at 180 degrees. A unique imaging algorithm combines the co-registered images from the detector heads and provides several SPECT tomographic reconstructions of the imaged object thereby improving the diagnostic quality especially in the case of imaging requiring higher spatial resolution and sensitivity at the same time. |
| FILED | Friday, January 23, 2009 |
| APPL NO | 12/321667 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Radiant energy 250/363.50 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073026 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| INVENTOR(S) | Zenghu Chang (Manhattan, Kansas); Chengquan Li (Sunnyvale, California); Eric Moon (Manhattan, Kansas) |
| ABSTRACT | A chirped pulse amplification laser system. The system generally comprises a laser source, a pulse modification apparatus including first and second pulse modification elements separated by a separation distance, a positioning element, a measurement device, and a feedback controller. The laser source is operable to generate a laser pulse and the pulse modification apparatus operable to modify at least a portion of the laser pulse. The positioning element is operable to reposition at least a portion of the pulse modification apparatus to vary the separation distance. The measurement device is operable to measure the carrier envelope phase of the generated laser pulse and the feedback controller is operable to control the positioning element based on the measured carrier envelope phase to vary the separation distance of the pulse modification elements and control the carrier envelope phase of laser pulses generated by the laser source. |
| FILED | Thursday, June 21, 2007 |
| APPL NO | 12/306348 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Coherent light generators 372/29.11 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073564 | Bruemmer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | David J. Bruemmer (Idaho Falls, Idaho); Miles C. Walton (Idaho Falls, Idaho) |
| ABSTRACT | Methods and systems for controlling a plurality of robots through a single user interface include at least one robot display window for each of the plurality of robots with the at least one robot display window illustrating one or more conditions of a respective one of the plurality of robots. The user interface further includes at least one robot control window for each of the plurality of robots with the at least one robot control window configured to receive one or more commands for sending to the respective one of the plurality of robots. The user interface further includes a multi-robot common window comprised of information received from each of the plurality of robots. |
| FILED | Wednesday, July 05, 2006 |
| APPL NO | 11/428757 |
| ART UNIT | 3665 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Data processing: Generic control systems or specific applications 7/245 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073859 | Wong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Memorial Institute (Columbus, Ohio) |
| INVENTOR(S) | Pak Chung Wong (Richland, Washington); Elizabeth R. Jurrus (Kennewick, Washington); Wendy E. Cowley (Benton City, Washington); Harlan P. Foote (Richland, Washington); James J. Thomas (Richland, Washington) |
| ABSTRACT | One or more processors (22) are operated to extract a number of different event identifiers therefrom. These processors (22) are further operable to determine a number a display locations each representative of one of the different identifiers and a corresponding time. The display locations are grouped into sets each corresponding to a different one of several event sequences (330a, 330b, 330c. 330d, 330e). An output is generated corresponding to a visualization (320) of the event sequences (330a, 330b, 330c, 330d, 330e). |
| FILED | Wednesday, May 06, 2009 |
| APPL NO | 12/436391 |
| ART UNIT | 2162 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/758 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 08070930 | Penner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Reginald Mark Penner (Laguna Beach, California); Michael Paul Zach (Irvine, California); Fred Favier (Saint Clemente de Riviere, France) |
| ABSTRACT | Methods for the preparation of long, dimensionally uniform, metallic nanowires that are removable from the surface on which they are synthesized. The methods include the selective electrodeposition of metal nanowires at step edges present on a stepped surface, such as graphite, from an aqueous solution containing a metal or metal oxide. Where a metal oxide is first deposited, the metal oxide nanowires are reduced via a gas phase reduction at elevated temperatures to metal nanowires. Alternatively, beaded or hybrid nanowires comprising a metal A into which nanoparticles of a metal B have been inserted may be prepared by first electrodepositing nanoparticles of metal B selectively along step edges of a stepped surface, capping these nanoparticles with a molecular layer of an organic ligand, selectively electrodepositing nanowire segments of metal A between nanoparticles of metal B and then heating the surface of the hybrid nanowire under reducing conditions to remove the ligand layer. In all three methods, the nanowires may be removed from the stepped surface by embedding the wires in a polymer film, and then peeling this film containing the embedded wires off of the stepped surface. |
| FILED | Monday, April 30, 2007 |
| APPL NO | 11/742223 |
| ART UNIT | 1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Electrolysis: Processes, compositions used therein, and methods of preparing the compositions 25/118 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08070959 | Kanatzidis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Mercouri Kanatzidis (Wilmette, Illinois); Emmanouil Manos (Evanston, Illinois); Nan Ding (Lexington, South Carolina) |
| ABSTRACT | Chalcogenide compounds with cation exchange capability and methods of using the compounds are described. Compounds of the general formula A2xMxSn3-xS6 are described wherein x is 0.1-0.95, A is Li+, Na+, K+ or Rb+ and M is Mn2+, Mg2+, Zn2+, Fe2+, Co2+ or Ni2+. Compounds of the general formula H2xMxSn3-xS6 are also described wherein x is 0.1-0.95 and M=Mn2+, Mg2+, Zn2+, Fe2+, Co2+ or Ni2+. The compounds can be layered compounds. The compounds are capable of intercalation of Cs+, Sr2+, Hg2+, Pb2+, Cd2+, and/or Ag+ ions. A process involving contacting the compounds with a solution comprising one or more ions including Cs+, Sr2+, Hg2+, Pb2+, Cd2+, and/or Ag+ is also provided. The one or more ions can be removed from the solution by the compounds. A process comprising contacting compounds of the general formula A2xMxSn3-xS6 with a solution containing UO22+, Th4+ or Pu4+ ions is also described. |
| FILED | Tuesday, October 07, 2008 |
| APPL NO | 12/285493 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Liquid purification or separation 210/688 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071031 | Byrne |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | Robert H. Byrne (St. Petersburg, Florida) |
| ABSTRACT | A device for the precise and accurate potentiometric pH measurements in situ. Embodiments of a potentiometric device according to the invention consist of one or more glass pH-sensitive electrodes connected to a potentiometer. A key feature of the device is that, rather than being calibrated conventionally with buffers, it can be calibrated with an in situ device that measures pH spectrophotometrically. Spectrophotometric pH measurements obtained via sulfonephthalein absorbance measurements are inherently calibrated (do not require buffers). Thus, devices according to the invention allow for continuous potentiometric pH measurements with occasional spectrophotometric calibrations. The spectrophotometric calibration device consists of a spectrophotometer with associated pumps for combining a sulfonephthalein pH indicator with the aqueous medium whose pH is to be measured. The device will record potentiometric pH measurements for an extended period of time until the spectrophotometric device is autonomously activated for another calibration. In this manner precise and accurate pH measurements can be obtained continuously in the environment, and the low energy expenditure of the potentiometric device provides excellent endurance. Also provided is a method and associated devices for spectrophotometrically determining the salinity of an aqueous medium. |
| FILED | Friday, March 25, 2011 |
| APPL NO | 13/072230 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing 422/82.10 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071082 | Zugates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Gregory T. Zugates (Cambridge, Massachusetts); Andreas Zumbuehl (Bern, Switzerland); Robert S. Langer (Newton, Massachusetts); Daniel G. Anderson (Sudbury, Massachusetts) |
| ABSTRACT | Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers. |
| FILED | Friday, July 20, 2007 |
| APPL NO | 11/780754 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/78.370 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071164 | Dugger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sandia Corporation (Albuquerque, New Mexico) |
| INVENTOR(S) | Michael T. Dugger (Tijeras, New Mexico); James A. Ohlhausen (Albuquerque, New Mexico); David B. Asay (Boalsburg, Pennsylvania); Seong H. Kim (State College, Pennsylvania) |
| ABSTRACT | A method is provided for tribological lubrication of sliding contact surfaces, where two surfaces are in contact and in motion relative to each other, operating in a vapor-phase environment containing at least one alcohol compound at a concentration sufficiently high to provide one monolayer of coverage on at least one of the surfaces, where the alcohol compound continuously reacts at the surface to provide lubrication. |
| FILED | Wednesday, May 07, 2008 |
| APPL NO | 12/116243 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Coating processes 427/248.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071255 | Schlenoff |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Florida State University Research Foundation (Tallahassee, Florida) |
| INVENTOR(S) | Joseph B. Schlenoff (Tallahassee, Florida) |
| ABSTRACT | A fuel cell comprising a proton transporting membrane is provided. The proton transporting membrane comprises a polyelectrolyte film comprising a multilayer comprising an interpenetrating network of a net positively charged polyelectrolyte polymer comprising repeat units with at least two fluorine atoms and a net negatively charged polyelectrolyte polymer comprising repeat units with at least two fluorine atoms, and further comprising a fluorinated counterion within the multilayer. |
| FILED | Friday, March 19, 2010 |
| APPL NO | 12/727930 |
| ART UNIT | 1764 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Chemistry: Electrical current producing apparatus, product, and process 429/494 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071316 | Khosla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Chaitan Khosla (Palo Alto, California); Lu Shan (Houston, Texas) |
| ABSTRACT | Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. |
| FILED | Monday, July 19, 2010 |
| APPL NO | 12/839278 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071358 | Dundon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Gevo, Inc. (Englewood, Colorado) |
| INVENTOR(S) | Catherine Asleson Dundon (Englewood, Colorado); Aristos Aristidou (Highlands Ranch, Colorado); Andrew Hawkins (Parker, Colorado); Doug Lies (Parker, Colorado); Lynne Albert (Golden, Colorado) |
| ABSTRACT | The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces Glade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms. |
| FILED | Thursday, September 08, 2011 |
| APPL NO | 13/228342 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/254.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071722 | Kaplan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Hyoung-Joon Jin (Seoul, South Korea); Gregory Rutledge (Newton, Massachusetts); Sergey Fridrikh (Acton, Massachusetts) |
| ABSTRACT | The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo. |
| FILED | Friday, January 15, 2010 |
| APPL NO | 12/688014 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/353 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071760 | Vicente et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Maria da Graça Henriques Vicente (Baton Rouge, Louisiana); Erhong Hao (Anhui, China PRC) |
| ABSTRACT | Boron-containing porphyrin compounds are disclosed that may be used for boron neutron capture therapy of tumors, radiotherapy of tumors, and photodynamic therapy of tumors. |
| FILED | Wednesday, October 25, 2006 |
| APPL NO | 12/091211 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Organic compounds 540/145 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071945 | Krishna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | STC.UNM (Albuquerque, New Mexico); Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Sanjay Krishna (Albuquerque, New Mexico); Majeed M. Hayat (Albuquerque, New Mexico); J. Scott Tyo (Tucson, Arizona); Woo-Yong Jang (Albuquerque, New Mexico) |
| ABSTRACT | Exemplary embodiments provide an infrared (IR) retinal system and method for making and using the IR retinal system. The IR retinal system can include adaptive sensor elements, whose properties including, e.g., spectral response, signal-to-noise ratio, polarization, or amplitude can be tailored at pixel level by changing the applied bias voltage across the detector. “Color” imagery can be obtained from the IR retinal system by using a single focal plane array. The IR sensor elements can be spectrally, spatially and temporally adaptive using quantum-confined transitions in nanoscale quantum dots. The IR sensor elements can be used as building blocks of an infrared retina, similar to cones of human retina, and can be designed to work in the long-wave infrared portion of the electromagnetic spectrum ranging from about 8 μm to about 12 μm as well as the mid-wave portion ranging from about 3 μm to about 5 μm. |
| FILED | Friday, August 01, 2008 |
| APPL NO | 12/184491 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Radiant energy 250/338.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072005 | Dehon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Brown University Research Foundation (Providence, Rhode Island) |
| INVENTOR(S) | Andre Dehon (Philadelphia, Pennsylvania); Charles M. Lieber (Lexington, Massachusetts); John E. Savage (Providence, Rhode Island); Eric Rachlin (Providence, Rhode Island) |
| ABSTRACT | Disclosed is a method to construct a device that includes a plurality of nanowires (NWs) each having a core and at least one shell. The method includes providing a plurality of radially encoded NWs where each shell contains one of a plurality of different shell materials; and differentiating individual ones of the NWs from one another by selectively removing or not removing shell material within areas to be electrically coupled to individual ones of a plurality of mesowires (MWs). Also disclosed is a nanowire array that contains radially encoded NWs, and a computer program product useful in forming a nanowire array. |
| FILED | Thursday, February 02, 2006 |
| APPL NO | 11/883679 |
| ART UNIT | 2891 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/208 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072117 | Zalalutdinov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Cornell Research Foundation, Inc. (Ithaca, New York); Naval Research Laboratory (Washington, District of Columbia) |
| INVENTOR(S) | Maxim Zalalutdinov (Silver Springs, Maryland); Robert B. Reichenbach (Ithaca, New York); Keith Aubin (Freeville, New York); Brian H. Houston (Fairfax, Virginia); Jeevak M. Parpia (Ithaca, New York); Harold G. Craighead (Ithaca, New York) |
| ABSTRACT | A source signal is converted into a time-variant temperature field with transduction into mechanical motion. In one embodiment, the conversion of a source signal into the time-variant temperature field is provided by utilizing a micro-fabricated fast response, bolometer-type radio frequency power meter. A resonant-type micromechanical thermal actuator may be utilized for temperature read-out and demodulation. |
| FILED | Monday, February 20, 2006 |
| APPL NO | 11/358917 |
| ART UNIT | 2618 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Electrical generator or motor structure 310/306 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073026 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| INVENTOR(S) | Zenghu Chang (Manhattan, Kansas); Chengquan Li (Sunnyvale, California); Eric Moon (Manhattan, Kansas) |
| ABSTRACT | A chirped pulse amplification laser system. The system generally comprises a laser source, a pulse modification apparatus including first and second pulse modification elements separated by a separation distance, a positioning element, a measurement device, and a feedback controller. The laser source is operable to generate a laser pulse and the pulse modification apparatus operable to modify at least a portion of the laser pulse. The positioning element is operable to reposition at least a portion of the pulse modification apparatus to vary the separation distance. The measurement device is operable to measure the carrier envelope phase of the generated laser pulse and the feedback controller is operable to control the positioning element based on the measured carrier envelope phase to vary the separation distance of the pulse modification elements and control the carrier envelope phase of laser pulses generated by the laser source. |
| FILED | Thursday, June 21, 2007 |
| APPL NO | 12/306348 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Coherent light generators 372/29.11 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073052 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Qian Xu (College Station, Texas); Vladimir M. Stankovic (Lancaster, United Kingdom); Zixiang Xiong (Spring, Texas) |
| ABSTRACT | A system and method for video coding. Energy-concentrating transform operations are performed on video data to obtain transformed data. Nested scalar quantization is performed on the transformed data to generate blocks of coset indices. Bit planes of the blocks of coset indices are encoded using irregular repeat accumulate (IRA) encoders to generate corresponding bit streams. The bit streams are transmitted to a destination device over a channel. A decoder of the destination device receives input data, corresponding to transmitted bit streams, from the channel. The input data is decoded, using side information, to obtain estimates for the blocks of coset indices. Output video data (i.e., an estimate of the original video data) is generated using the estimated blocks of coset indices and the side information. |
| FILED | Thursday, July 27, 2006 |
| APPL NO | 11/494678 |
| ART UNIT | 2485 — Recording and Compression |
| CURRENT CPC | Pulse or digital communications 375/240.30 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073210 | Reinhardt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of lowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Joseph Reinhardt (Iowa City, Iowa); Milan Sonka (Coralville, Iowa); Geoffrey McLennan (Iowa City, Iowa); Eric Hoffman (Iowa City, Iowa); Soumik Ukil (Iowa City, Iowa) |
| ABSTRACT | Automated methods for segmenting and smoothing volumes of interest, such as the mediastinal boundary of a lung. Devices and systems configured to perform the automated methods. |
| FILED | Tuesday, February 14, 2006 |
| APPL NO | 11/355321 |
| ART UNIT | 2624 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/128 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073549 | Chen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | Wei Chen (Tampa, Florida) |
| ABSTRACT | Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. Na/K pump molecules were used as an example in a physiological operating mode by applying the concept of an electronic synchrotron to the biological system. It was shown that individual Na/K pump molecules can be synchronized by a well designed oscillating electric field. The synchronized pump currents show separated inward and outward pump currents and a magnitude ratio of 3:2 reflecting stoichiometric number of the pump molecules. |
| FILED | Monday, April 19, 2010 |
| APPL NO | 12/762708 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Surgery: Light, thermal, and electrical application 67/76 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073622 | Said et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Ryan Khalil Said (Palo Alto, California); Umran Savas Inan (Stanford, California) |
| ABSTRACT | A long-range lightning detection and characterization system and method. Electromagnetic radiation produced by a lightning strike is sensed at a sensing location and a measured signal representative of the strike is produced that defines an amplitude versus time. A set of reference data containing waveforms comparable to the measured signal is established. The set of reference data defines a set of reference amplitudes versus time, representative of one or more predetermined reference lightning strikes at various predetermined distances, where for each of the distances, the reference lightning strikes have associated therewith various predetermined day/night percentages. The measured signal is compared with the reference data, the comparison including finding a correlation between the measured signal and a correlating waveform in the reference data. At least one of a propagation distance, a time-of-arrival, a polarity, and an amplitude of the measured signal is inferred by reference to the correlating waveform. |
| FILED | Monday, May 12, 2008 |
| APPL NO | 12/152232 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/4 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073869 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Chen Li (Irvine, California); Shengyue Ji (Irvine, California); Guoliang Li (Beijing, China PRC); Jiannan Wang (Beijing, China PRC); Jianhua Feng (Beijing, China PRC) |
| ABSTRACT | A method to support efficient, interactive, and fuzzy search on text data includes an interactive, fuzzy search on structured data used in applications such as query relaxation, autocomplete, and spell checking, where inconsistencies and errors exist in user queries as well as data. It utilizes techniques to efficiently and interactively answer fuzzy queries on structured data to allow users to efficiently search for information interactively, and they can find records and documents even if these records and documents are slightly different from the user keywords. |
| FILED | Thursday, July 02, 2009 |
| APPL NO | 12/497489 |
| ART UNIT | 2167 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/780 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 08071553 | Hefeneider et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of American as represented by the Department of Veterans Affairs (Washington, District of Columbia); Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | Steven H. Hefeneider (Portland, Oregon); Sharon L. McCoy (Portland, Oregon) |
| ABSTRACT | Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used as therapy to reduce and/or inhibit, or initiate and/or enhance, an inflammatory response in a subject. |
| FILED | Friday, June 05, 2009 |
| APPL NO | 12/479645 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/21.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071759 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Affymetrix, Inc. (Santa Clara, California) |
| INVENTOR(S) | Lijun Huang (Waterville, Ohio); Benjamin R. Travis (Maumee, Ohio) |
| ABSTRACT | Four novel water soluble cholesterol derivative compounds are disclosed. These compounds have various applications in studies of membrane proteins, including drug screening and studies of receptor stability and folding. In one aspect the water soluble cholesterol derivatives disclosed may be used to replace cholesterol in micelle-solubilized membrane protein preparations. |
| FILED | Monday, June 29, 2009 |
| APPL NO | 12/494159 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Organic compounds 536/123.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071947 | Garman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Opto-Knowledge Systems, Inc. (Torrance, California) |
| INVENTOR(S) | John Garman (Long Beach, California); Nahum Gat (Manhattan Beach, California) |
| ABSTRACT | A variable aperture assembly for an infrared camera for use with optics having two or more f-numbers. The variable aperture assembly includes a variable iris disposed substantially along an axis of the infrared camera and is thermally connected to a cooling assembly. The variable iris is capable of causing an infrared radiation admitting opening to vary in size. The infrared radiation admitting openings of the variable aperture assembly can be circular or non-circular, including generally rectangular or racetrack shaped openings. The variable aperture assembly provides f-number matching by adjusting the infrared radiation admitting opening to the size necessary to effectively match the numerous f-numbers of the optics, or by adjusting to a size so that a fixed aperture on the radiation shield becomes the effective aperture stop, providing the f-number matching. |
| FILED | Tuesday, November 04, 2008 |
| APPL NO | 12/264864 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Radiant energy 250/352 |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 08071395 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Ronald W. Davis (Palo Alto, California); Stefanie S. Jeffrey (Los Altos Hills, California); Michael N. Mindrinos (Menlo Park, California); R. Fabian Pease (Stanford, California); Ashley Ann Powell (Mountain View, California); AmirAli Hajhossein Talasaz (Los Altos, California) |
| ABSTRACT | Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput. |
| FILED | Thursday, December 11, 2008 |
| APPL NO | 12/333213 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/524 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071573 | Sanders et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois, a Body Corporate and Politic of the State of Illinois (Urbana, Illinois) |
| INVENTOR(S) | John M. Sanders (Collegeville, Pennsylvania); Yongcheng Song (Pearland, Texas); Julian M. W. Chan (Boston, Massachusetts); Eric Oldfield (Champaign, Illinois); Yonghui Zhang (Urbana, Illinois) |
| ABSTRACT | Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy. |
| FILED | Monday, June 28, 2010 |
| APPL NO | 12/825218 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/89 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08073655 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | AT and T Intellectual Property II, L.P. (, None); The Board of Trustees of The University of Illinois, a body corporate and politic of The State of Illinois (, None) |
| INVENTOR(S) | Shuyi Chen (Urbana, Illinois); William Sanders (Mahomet, Illinois); Matti Hiltunen (Chatham, New Jersey); Kaustubb Joshi (Scotch Plains, New Jersey); Richard Schlichting (New Providence, New Jersey) |
| ABSTRACT | A method for measuring system response sensitivity, using live traffic and an analysis that converts randomly arriving stimuli and reactions to the stimuli to mean measures over chosen intervals, thereby creating periodically occurring samples that are processed. The system is perturbed in a chosen location of the system in a manner that is periodic with frequency p, and the system's response to arriving stimuli is measured at frequency p. The perturbation, illustratively, is with a square wave pattern. |
| FILED | Friday, January 23, 2009 |
| APPL NO | 12/321623 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/182 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 08069657 | Gray, Jr. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the U.S. Environmental Protection Agency (Washington, District of Columbia) |
| INVENTOR(S) | Charles L. Gray, Jr. (Pinckney, Michigan) |
| ABSTRACT | A diesel combustion engine comprises multiple particulate filters and corresponding exhaust piping and valving in the exhaust manifold and/or exhaust line, configured to enable regeneration to occur in one of the DPF filters through heating the exhaust from a single cylinder of the engine, while the exhaust from the remaining cylinders is temporarily routed through the other DPF filter during the regeneration event. Flow redirection devices are placed within the DPF filters to direct flow of exhaust gas through the DPF filters during regeneration in a manner to facilitate complete regeneration, including in outer volumes along the interior walls of the DPF filters. |
| FILED | Wednesday, June 04, 2008 |
| APPL NO | 12/156692 |
| ART UNIT | 3748 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Power plants 060/295 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08071358 | Dundon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Gevo, Inc. (Englewood, Colorado) |
| INVENTOR(S) | Catherine Asleson Dundon (Englewood, Colorado); Aristos Aristidou (Highlands Ranch, Colorado); Andrew Hawkins (Parker, Colorado); Doug Lies (Parker, Colorado); Lynne Albert (Golden, Colorado) |
| ABSTRACT | The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces Glade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms. |
| FILED | Thursday, September 08, 2011 |
| APPL NO | 13/228342 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/254.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 08070105 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Christopher J. Johnson (Houston, Texas); Jasen L. Raboin (League City, Texas); Gary R. Spexarth (Houston, Texas) |
| ABSTRACT | An inflatable structure comprises at least two generally toroidal, inflatable modules. When in a deployed mode, the first, inner module has a major diameter less than that of a second, outer module and is positioned within the inner circumference of the outer module such that the first module is nested circumferentially alongside the second module. The inflatable structure, in a non-deployed, non-inflated mode, is of compact configuration and adapted to be transported to a site of deployment. When deployed, the inflatable structure is of substantially increased interior volume. In one embodiment, access between the interior of the first module and the second module is provided by at least one port or structural pass-through. In another embodiment, the inflatable structure includes at least one additional generally toroidal module external of and circumferentially surrounding the second module. |
| FILED | Friday, December 14, 2007 |
| APPL NO | 11/956826 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeronautics and astronautics 244/158.300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072584 | Caldwell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Ophir Corporation (Littleton, Colorado) |
| INVENTOR(S) | Loren M. Caldwell (Ft. Collins, Colorado); Shoou-yu Tang (Ft. Collins, Colorado); Phillip E. Acott (Ft. Collins, Colorado); Lisa G. Spaeth (Littleton, Colorado); Martin O'Brien (Conifer, Colorado) |
| ABSTRACT | Systems and methods for sensing air includes at least one, and in some embodiments three, transceivers for projecting the laser energy as laser radiation to the air. The transceivers are scanned or aligned along several different axes. Each transceiver receives laser energy as it is backscattered from the air. A computer processes signals from the transceivers to distinguish molecular scattered laser radiation from aerosol scattered laser radiation and determines air temperatures, wind speeds, and wind directions based on the scattered laser radiation. Applications of the system to wind power site evaluation, wind turbine control, traffic safety, general meteorological monitoring and airport safety are presented. |
| FILED | Thursday, June 12, 2008 |
| APPL NO | 12/138163 |
| ART UNIT | 3665 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Optics: Measuring and testing 356/28.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 08071841 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Li Li (Ithaca, New York); Joyce Van Eck (Ithaca, New York) |
| ABSTRACT | The cauliflower (Brassica oleracea L. var. botrytis) Or gene is a semi-dominant, single-locus mutation. It induces the accumulation of high levels of beta-carotene in various tissues that are normally devoid of carotenoids, turning them orange. Using a map-based cloning strategy, we identified a single gene representing Or and successfully verified its identity by functional complementation in the wild type cauliflower. The Or gene encodes a plastid membrane protein containing the DnaJ zinc figure domain. A likely gain-of-function mutation from a 4.3-kb retrotransposon insertion in the Or allele confers the orange phenotype in the mutant. Southern blot analysis revealed that Or is a single-copy sequence in the cauliflower genome. High level of expression of the Or gene and the protein was found in very young leaves, curds, and flowers at comparable abundance between wild type and the Or mutant. Or likely functions in regulating the differentiation of some non-photosynthetic plastids into chromoplasts, which provide the deposition “sink” for carotenoid accumulation. Successful demonstration of Or in conferring carotenoid accumulation in potato tubers indicates its potential use to improve the nutritional value in staple crops. |
| FILED | Thursday, December 14, 2006 |
| APPL NO | 11/639064 |
| ART UNIT | 1638 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Multicellular living organisms and unmodified parts thereof and related processes 8/282 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 08070854 | Grzeslak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Kazimierz T. Grzeslak (Bedford, New Hampshire); Jason Stockwell (Brookline, New Hampshire) |
| ABSTRACT | In a method for removing moisture from an optical system at high altitude, the improvement comprises using the difference in flow resistance between the desiccant path and the optical cavity path to enable airflow through the desiccant unit and not through the optical path. |
| FILED | Monday, March 07, 2011 |
| APPL NO | 12/932802 |
| ART UNIT | 1776 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Gas separation: Processes 095/117 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 08071553 | Hefeneider et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of American as represented by the Department of Veterans Affairs (Washington, District of Columbia); Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | Steven H. Hefeneider (Portland, Oregon); Sharon L. McCoy (Portland, Oregon) |
| ABSTRACT | Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used as therapy to reduce and/or inhibit, or initiate and/or enhance, an inflammatory response in a subject. |
| FILED | Friday, June 05, 2009 |
| APPL NO | 12/479645 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/21.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 08071373 | Warren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Sanofi Pasteur Vaxdesign Corp. (Orlando, Florida); Virginia Commonwealth University (Richmond, Virginia) |
| INVENTOR(S) | William L. Warren (Orlando, Florida); Donald Drake, III (Orlando, Florida); Janice Moser (Orlando, Florida); Inderpal Singh (Oviedo, Florida); Haifeng Song (Germantown, Maryland); Eric Mishkin (Winter Springs, Florida); John G. Tew (Mechanicsville, Virginia) |
| ABSTRACT | The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. |
| FILED | Thursday, June 15, 2006 |
| APPL NO | 11/453046 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/347 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 08073196 | Yuan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Chang Yuan (Vancouver, Washington); Gerard Medioni (Los Angeles, California); Jinman Kang (San Jose, California); Isaac Cohen (Minnetonka, Minnesota) |
| ABSTRACT | Among other things, methods, systems and computer program products are described for detecting and tracking a moving object in a scene. One or more residual pixels are identified from video data. At least two geometric constraints are applied to the identified one or more residual pixels. A disparity of the one or more residual pixels to the applied at least two geometric constraints is calculated. Based on the detected disparity, the one or more residual pixels are classified as belonging to parallax or independent motion and the parallax classified residual pixels are filtered. Further, a moving object is tracked in the video data. Tracking the object includes representing the detected disparity in probabilistic likelihood models. Tracking the object also includes accumulating the probabilistic likelihood models within a number of frames during the parallax filtering. Further, tracking the object includes based on the accumulated probabilistic likelihood models, extracting an optimal path of the moving object. |
| FILED | Tuesday, October 16, 2007 |
| APPL NO | 11/873390 |
| ART UNIT | 2624 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/103 |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 08073782 | Dillard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | United States Postal Service (Washington, District of Columbia) |
| INVENTOR(S) | Leon Nathaniel Dillard (Woodbridge, Virginia); Wayne Alan Wilkerson (Manassas, Virginia); Roy Roger Gordon (Gaithersburg, Maryland) |
| ABSTRACT | There is provided a cryptographic round dater and its method of use. By capturing customer profile information and encoding the information on a label affixed to the customer's submitted mailpiece, fraudulent or criminal use of the mail may be deterred by providing traceability to the source of the mail piece. The information attached to the mailpiece may be both human readable and machine readable, said machine readable portion being optionally encrypted to protect the privacy and security of the encoded information. Further benefit is provided by allowing the handling of a mailpiece to be traced, allowing for effective remediation or investigation in the event of an unauthorized use of mail. |
| FILED | Tuesday, December 23, 2003 |
| APPL NO | 10/746099 |
| ART UNIT | 3685 — Business Methods - Incentive Programs, Coupons; Electronic Shopping; Business Cryptography, Voting; Health Care; Point of Sale, Inventory, Accounting; Business Processing, Electronic Negotiation |
| CURRENT CPC | Data processing: Financial, business practice, management, or cost/price determination 75/62 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 08072220 | Dolgin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Raytheon UTD Inc. (Springfield, Virginia) |
| INVENTOR(S) | Benjamin P. Dolgin (Alexandria, Virginia); Michael Shore (Chapel Hill, North Carolina); Steven A. Cotten (Dumfries, Virginia); Craig E. Matter (Ashburn, Virginia); Kenneth D. Kuck (Fairfax, Virginia); Luis B. Giraldo (Fairfax, Virginia); John T. Ishibashi (Burke, Virginia) |
| ABSTRACT | A positioning, communication, and detection system designed to provide a three dimensional location of an object, navigation tools, and bidirectional surface-to-subsurface communications, and methods of using the system. The system can include one or multiple transmitters comprising electromagnetic beacons, software defined radio receivers with an associated processing unit and data acquisition system, and magnetic antennas. The system may use theoretical calculations, scale model testing, signal processing, and sensor data. |
| FILED | Wednesday, March 26, 2008 |
| APPL NO | 12/078069 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/329 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08072843 | Butler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Image Acoustics, Inc. (Cohasset, Massachusetts) |
| INVENTOR(S) | John L. Butler (Cohasset, Massachusetts); Alexander L. Butler (Weymouth, Massachusetts) |
| ABSTRACT | An electro-mechanical transducer is disclosed, which provides a wideband response by activating successive multiple resonant frequencies in a way which provides additive output between the resonant frequencies with reduced cancellation below the first resonance and means for controlling the response by reducing the voltage drive. A multiply resonant wideband high output transducer is disclosed. |
| FILED | Wednesday, March 18, 2009 |
| APPL NO | 12/381991 |
| ART UNIT | 3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Communications, electrical: Acoustic wave systems and devices 367/158 |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, December 06, 2011.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2011/fedinvent-patents-20111206.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page