FedInvent™ Patents
Patent Details for Tuesday, December 04, 2012
This page was updated on Monday, March 27, 2023 at 03:27 AM GMT
Department of Defense (DOD)
| US 08322064 | Cabahug et al. |
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| ASSIGNEE(S) | Prototype Poductions Incorporated Ventures Two, LLC (Ashburn, Virginia) |
| INVENTOR(S) | Eric F. Cabahug (Fairfax, Virginia); James S. Dodd (Linden, Virginia); Ben Feldman (Reston, Virginia) |
| ABSTRACT | A firearm may have a plurality of power-consuming accessories that can be attached to the weapon. In order to reduce the weight of these power-consuming accessories, as well as the proliferation of their batteries, the Weapons Accessory Power Distribution System provides a common power source to power the power-consuming accessories attached to the weapon. One or more powered rails are provided on the handguard, which encircles the barrel of the weapon, to provide a point of mechanical and electrical interconnection for the power-consuming accessories to provide quick connect mounting and dismounting of the power-consuming accessory, absent the use of connectors with their tethering cables, which are susceptible to entanglement. The powered rail(s) are electrically interconnected with a power source, which typically is a battery mounted in the butt stock of the weapon. |
| FILED | Friday, February 10, 2012 |
| APPL NO | 13/370629 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Firearms 042/85 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322221 | Sathish et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Shamachary Sathish (Bellbrook, Ohio); John T. Welter (Fairborn, Ohio); Kumar V. Jata (Yellow Springs, Ohio); Richard Reibel (Dayton, Ohio) |
| ABSTRACT | A non-contact near field high resolution acoustic imaging system of a sample, the system including an acoustic wave generator generating a plurality of acoustic waves a ultrasonic horn amplifying the waves to an amplitude of between about 20 microns and about 300 microns, and a frequency between about 20 kHz and about 40 khz. The ultrasonic horn further directs the amplified waves to impinge upon the sample. On contact between the waves and the sample, a plurality of transmitted energy is transmitted to the sample, a plurality of longitudinal displacements and surface acoustic wave displacements in the sample are created. An adjustable separation distance lies between the sample and the ultrasonic horn, the distance adjusted to maximize the transmitted energy. The distance is preferably greater than the maximum displacement of the ultrasonic horn, or approximately 0.1 mm. The non-contact near field high resolution acoustic imaging system further includes a surface displacement detector for detecting the longitudinal wave displacements or surface acoustic wave displacements, the detector including a tip and a tip diameter; and a computer for digitizing and storing the longitudinal wave displacements or surface acoustic wave displacements. The longitudinal displacements or surface acoustic wave displacements are analyzed to create an image of at least a portion of the sample, the image alternatively having a resolution about equal to the surface displacement detector tip diameter. |
| FILED | Thursday, March 26, 2009 |
| APPL NO | 12/411826 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/606 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322231 | O'Rourke et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Jack R. O'Rourke (Panama City, Florida); Robert L. Peebles (Panama City, Florida); Danny L. Smith (Panama City, Florida) |
| ABSTRACT | A hydrostatic force/displacement measuring device measures the force and displacement exerted by a rotating tire in soil/aggregate. The measuring device has a hydrostatic actuation assembly having a pressure plate at near surface depths of soil/aggregate to provide hydrostatic pressures in a liquid representative of force and displacement created by the downward forces exerted by a rotating tire in the soil/aggregate at the near surface depths. A hydrostatic hose transmits the hydrostatic pressure forces in the liquid to a surface manifold assembly. The surface manifold assembly receives the hydrostatic pressure forces and has a gauge providing visual readouts of the hydrostatic pressure forces representative of the downward forces. The surface manifold assembly also has an axially displaceable piston defining an interface chamber. The piston is connected to an electronic sensor to provide visual readouts representative of displacements caused by the downward force. |
| FILED | Tuesday, May 04, 2010 |
| APPL NO | 12/800820 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/862.581 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322264 | Van De Wal |
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| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Brian James Van De Wal (Schodack Landing, New York) |
| ABSTRACT | A pressure release mechanism for a sonic rarefaction wave-type low-recoil gun system employing controlled plastic venting that exhibits adiabatic shear banding to effect a delayed pressure release. |
| FILED | Wednesday, February 13, 2008 |
| APPL NO | 12/030223 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ordnance 089/1.703 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322265 | Singer |
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| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Irwin L. Singer (Alexandria, Virginia) |
| ABSTRACT | In an electromagnetic rail gun launcher that includes a set of spaced-apart rails defining an inside bore for slidably receiving an armature-type projectile, with the rail gun and armature configured such that when powered up the projectile is forced from a breech of the rail gun toward a muzzle of the rail gun to then launch the projectile, the improvement wherein a lubricant reconditioning pad, containing a lubricant, is secured to the projectile in a location such that it contacts the rails. As the projectile moves through the bore, the pad cleans debris from, and applies lubricant to, the rails to thereby lubricate and recondition the rails during each shot. |
| FILED | Thursday, June 24, 2010 |
| APPL NO | 12/822794 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ordnance 089/8 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322267 | Altergott et al. |
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| ASSIGNEE(S) | Triton Systems, Inc. (Chelmsford, Massachusetts) |
| INVENTOR(S) | William Altergott (Uxbridge, Massachusetts); Thomas J. Carroll (Salem, New Hampshire); James J. Gorman (Boxborough, Massachusetts); George Santiago (Marlborough, Massachusetts) |
| ABSTRACT | An armor repair kit including repair putty and a scrim having a plurality of ceramic constituents attached thereto and methods for using a repair putty, scrims and kits to repair damaged armor are described herein. |
| FILED | Wednesday, June 03, 2009 |
| APPL NO | 12/477355 |
| ART UNIT | 3633 — Static Structures, Supports and Furniture |
| CURRENT CPC | Ordnance 089/36.20 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322295 | Hoffman et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Mark W. Hoffman (Manassas, Virginia); Robert Kent Tacey (Alexandria, Virginia); Erwin Thomas Moyer (Winterville, North Carolina); Jason S. Craft (Germantown, Maryland); Ronald S. Barbaro (Fairfax, Virginia) |
| ABSTRACT | An arrangement and a method for implosion mitigation, and in particular a structural arrangement of a water vessel and a method thereof for mitigating implosion loads. The water vessel includes first and second end portions connected by a middle portion, with one portion structurally weaker than the others so that when the vessel experiences an overmatching load, only the structurally weaker portion of the vessel fails. The vessel may further include energy absorbing structures. |
| FILED | Tuesday, April 14, 2009 |
| APPL NO | 12/423390 |
| ART UNIT | 3788 — Static Structures, Supports and Furniture |
| CURRENT CPC | Ships 114/312 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322470 | Ohm et al. |
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| ASSIGNEE(S) | iRobot Corporation (Bedford, Massachusetts) |
| INVENTOR(S) | Timothy R. Ohm (Grover Beach, California); Michael Bassett (Needham, Massachusetts) |
| ABSTRACT | Configurations are provided for vehicular robots or other vehicles to provide shifting of their centers of gravity for enhanced obstacle navigation. Various head and neck morphologies are provided to allow positioning for various poses such as a stowed pose, observation poses, and inspection poses. Neck extension and actuator module designs are provided to implement various head and neck morphologies. Robot control network circuitry is also provided. |
| FILED | Thursday, December 15, 2011 |
| APPL NO | 13/327209 |
| ART UNIT | 3611 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Motor vehicles 180/9.320 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322919 | Lagakos et al. |
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| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Nicholas Lagakos (Silver Spring, Maryland); Joseph A Bucaro (Herndon, Virginia) |
| ABSTRACT | A fiber-optic temperature sensor with a cantilever beam including two different material strips with different thermal expansion coefficients, the cantilever beam having a reflective surface on an end of the cantilever beam, an optical fiber probe including a transmitting multimode optical fiber and at least one receiving multimode optical fiber for receiving reflected light from the reflective surface. Temperature changes at the sensor are indicated by a change in reflected light coupled into the receiving multimode optical fiber due to lateral displacement of the edge of the reflective surface caused by bending of the cantilever beam. Some embodiments have additional reference receiving fibers for compensation for noise, changes in gap length, and other factors. |
| FILED | Tuesday, February 02, 2010 |
| APPL NO | 12/698646 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Thermal measuring and testing 374/130 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323032 | Deering |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Shad H. Deering (Dupont, Washington) |
| ABSTRACT | An embodiment of the invention provides a method wherein a simulation system having a simulator, a processor, and at least one display is assembled. This includes assembling a birthing mannequin and a mobile cart having at least one touch-screen monitor, wherein the birthing mannequin includes a means for shaking to simulate a generalized seizure. The simulation system is provided along with documentation to a plurality of medical facilities within a system. Training on use of the simulator, different simulations, and criteria for grading performance on the simulations is also provided. The training includes team training for conducting the simulations using the simulation system. |
| FILED | Wednesday, March 16, 2011 |
| APPL NO | 13/049497 |
| ART UNIT | 3715 — Amusement and Education Devices |
| CURRENT CPC | Education and demonstration 434/273 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323409 | Schlichting et al. |
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| ASSIGNEE(S) | United Technologies Corporation (Hartford, Connecticut) |
| INVENTOR(S) | Kevin W. Schlichting (Storrs, Connecticut); Donald G. Broadhurst (East Hartford, Connecticut); John H. Hyde (South Meriden, Connecticut); John F. Blondin (South Windsor, Connecticut) |
| ABSTRACT | Systems and methods for forming components with thermal barrier coatings are provided. In this regard, a representative method includes: providing a component having a first side and an opposing second side; and using a preformed mask to obstruct vapors from being deposited on the second side of the component while moving the component relative to the vapors such that the vapors form a thermal barrier coating on the first side of the component. |
| FILED | Thursday, May 08, 2008 |
| APPL NO | 12/117019 |
| ART UNIT | 1717 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Coating apparatus 118/720 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323436 | Sennett et al. |
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| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Michael Sennett (Sudbury, Massachusetts); Elizabeth A. Welsh (Westborough, Massachusetts); Jean M. Herbert (Woonsocket, Rhode Island); Phillip M. Cunniff (Shrewsbury, Massachusetts) |
| ABSTRACT | A transparent, reinforced, composite polymeric fiber that has a polymeric body portion made from a first thermoplastic polymer that is transparent to visible light. The fiber includes polymeric reinforcement elements embedded within the polymeric body portion. The polymeric body portion extends between and about the polymeric reinforcement elements. Each polymeric reinforcement element is formed from a second thermoplastic polymer that is transparent to visible light. The peripheral portion and outer surface of the polymeric body portion defines a peripheral portion and outer surface, respectively, of the transparent, reinforced, composite polymeric fiber. A plurality of the fibers are formed into an array that is processed with a consolidation process to form a transparent, reinforced, composite structure. |
| FILED | Wednesday, March 28, 2007 |
| APPL NO | 11/732669 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Adhesive bonding and miscellaneous chemical manufacture 156/181 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323784 | Green et al. |
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| ASSIGNEE(S) | Northwestern Universtiy (Evanston, Illinois) |
| INVENTOR(S) | Alexander A. Green (Evanston, Illinois); Mark C. Hersam (Evanston, Illinois) |
| ABSTRACT | Various methods related to the preparation of transparent electrical conductors based on carbon nanotubes having enhanced optical and electrical properties are disclosed. In some embodiments, the methods involve employing carbon nanotubes that have been presorted according to electronic type and/or optical absorbance for use in transparent electrical conductors. Other embodiments involve use of carbon nanotube bundles that have been pre-sorted according to bundle density. |
| FILED | Monday, August 25, 2008 |
| APPL NO | 12/229595 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Stock material or miscellaneous articles 428/220 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323796 | Schmidt et al. |
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| ASSIGNEE(S) | United Technologies Corporation (Hartford, Connecticut) |
| INVENTOR(S) | Wayde R. Schmidt (Pomfret Center, Connecticut); Tania Bhatia (Middletown, Connecticut); Xia Tang (West Hartford, Connecticut); David C. Jarmon (Kensington, Connecticut); Owen B. Donahue (Mystic, Connecticut) |
| ABSTRACT | A composite article includes a substrate and a protective layer on the substrate. The protective layer includes a non-oxide ceramic matrix and a refractory phase within the non-oxide ceramic matrix. |
| FILED | Tuesday, July 17, 2007 |
| APPL NO | 11/778692 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Stock material or miscellaneous articles 428/408 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323866 | Fedynyshyn et al. |
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| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Theodore H. Fedynyshyn (Sudbury, Massachusetts); Russell B. Goodman (Hingham, Massachusetts) |
| ABSTRACT | Methods and compositions for enhancing the sensitivity of an inorganic resist composition are disclosed. In one aspect, compositions for use with a matrix material (e.g., a lithographically sensitive polymeric material such as a hydrogen-bearing siloxane material) can be formulated with a sensitizer, where the sensitizer can be present in a relatively small amount. The sensitizer can include a radical generator, and can act to enhance the efficiency of radical generation and/or resist crosslinking when the resist is impinged by a selected lithographic radiation. The methods of the present invention can be especially useful in performing short wavelength (e.g., less than 200 nm) lithography, or for processes such as e-beam lithography, which traditionally suffer from low throughput. Methods of utilizing one or more of these aspects are also disclosed. |
| FILED | Monday, July 06, 2009 |
| APPL NO | 12/497851 |
| ART UNIT | 1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Radiation imagery chemistry: Process, composition, or product thereof 430/270.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323888 | Mirkin et al. |
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| ASSIGNEE(S) | Nanosphere, Inc. (Northbrook, Illinois) |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Robert L. Letsinger (Wilmette, Illinois); Robert C. Mucic (Glendale, California); James J. Storhoff (Evanston, Illinois); Robert Elghanian (Wilmette, Illinois); Thomas A. Taton (Little Canada, Minnesota) |
| ABSTRACT | The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids. |
| FILED | Friday, February 02, 2007 |
| APPL NO | 11/702002 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323956 | Reardon et al. |
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| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| INVENTOR(S) | Kenneth F. Reardon (Fort Collins, Colorado); Lawrence Philip Wackett (St. Paul, Minnesota) |
| ABSTRACT | Enzymatic biosensors and methods of producing distal tips for biosensor transducers for use in detecting one or more analytes selected from organic compounds susceptible to dehalogenation, organic compounds susceptible to oxygenation, organic compounds susceptible to deamination, organosulfate compounds susceptible to hydrolysis, and organophosphate compounds susceptible to hydrolysis are disclosed herein, as well as biosensor arrays, methods of detecting and quantifying analytes within a mixture, and devices and methods for delivering reagents to enzymes disposed within the distal tip of a biosensor. |
| FILED | Thursday, January 22, 2009 |
| APPL NO | 12/358140 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/287.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323975 | Kool |
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| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Eric T. Kool (Stanford, California) |
| ABSTRACT | Telomere-encoding nucleic acid nanocircles, methods for their preparation, and methods for their use are disclosed. The nanocircles can be constructed containing multiple repeats of the complement of telomere repeat sequences. The telomere-encoding nanocircles are useful for extending telomeres both in vitro and in vivo, for treating macular degeneration, the effects of skin aging, liver degeneration, and cancer. The nanocircles are further useful for treating cell cultures to produce long-lived non-cancerous cell populations. This use has wide applicability in scientific research, tissue engineering, and transplantation. |
| FILED | Monday, January 26, 2009 |
| APPL NO | 12/359448 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/455 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324030 | Bangsaruntip et al. |
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| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Sarunya Bangsaruntip (Mount Kisco, New York); Isaac Lauer (Mahopac, New York); Amlan Majumdar (White Plains, New York); Jeffrey W. Sleight (Ridgefield, Connecticut) |
| ABSTRACT | A method for forming a nanowire tunnel field effect transistor (FET) device includes forming a nanowire suspended by a first pad region and a second pad region, forming a gate around a portion of the nanowire, forming a protective spacer adjacent to sidewalls of the gate structure and around portions of the nanowire extending from the gate structure, implanting ions in a first portion of the exposed nanowire, removing a second portion of the exposed nanowire to form a cavity defined by the core portion of the nanowire surrounded by the gate structure and the spacer, exposing a silicon portion of the substrate, and epitaxially growing a doped semiconductor material in the cavity from exposed cross section of the nanowire, the second pad region, and the exposed silicon portion to connect the exposed cross sections of the nanowire to the second pad region. |
| FILED | Wednesday, May 12, 2010 |
| APPL NO | 12/778315 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/151 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324169 | Quinn |
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| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Timothy P. Quinn (San Francisco, California) |
| ABSTRACT | The present invention provides fusion proteins comprising an extracellular domain of a VEGF receptor and a death ligand. The fusion proteins bind to VEGF and to death receptors on tumor cells thereby inhibiting VEGF activation of VEGF receptors and inducing apoptosis in the tumor cells. Fusion proteins of the present invention are useful for inducing apoptosis and cytotoxic effects in cells, treating cancer and diseases or disorders related to unregulated angiogenesis and/or vasculogenesis. Thus, this invention further provides methods for treating angiogenesis related diseases using the fusion proteins, polynucleotides encoding the fusion proteins, vectors containing the polynucleotides, pharmaceutical compositions and kits containing the fusion proteins or the polynucleotides encoding the fusion proteins. |
| FILED | Tuesday, August 15, 2006 |
| APPL NO | 12/063897 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/18.900 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324357 | Chelyapov |
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| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Nicolas Chelyapov (Los Angeles, California) |
| ABSTRACT | A universal detection system based on allosteric aptamers, signal amplification cascade, and eye-detectable phrase transition. A broadly applicable homogeneous detection system is provided. It utilizes components of the blood coagulation cascade in the presence of polystyrene microspheres (MS) as a signal amplifier. Russell's viper venom factor X activator (RVV-X) triggers the cascade, which results in an eye-visible phase transition—precipitation of MS bound to clotted fibrin. An allosteric RNA aptamer, RNA132, with affinity for RVV-X and human vascular endothelial growth factor (VEGF165) was created. RNA132 inhibits enzymatic activity of RVV-X. The effector molecule, VEGF165, reverses the inhibitory activity of RNA132 on RVV-X and restores its enzymatic activity, thus triggering the cascade and enabling the phase transition. Similar results were obtained for another allosteric aptamer modulated by a protein tyrosine phosphatase. The assay is instrumentation-free for both processing and readout. |
| FILED | Tuesday, March 06, 2007 |
| APPL NO | 11/682796 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/23.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324438 | Brandvold et al. |
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| ASSIGNEE(S) | UOP LLC (Des Plaines, Illinois) |
| INVENTOR(S) | Timothy A. Brandvold (Arlington Heights, Illinois); Michael J. McCall (Geneva, Illinois) |
| ABSTRACT | A process for producing at least one blended fuel from a paraffin rich component and a cyclic rich component, where each of the components are generated from a renewable feedstock, is presented. The paraffin rich component is generated from glycerides and free fatty acids in feedstocks such as plant and animal oils. The cyclic rich component is generated from biomass derived pyrolysis oil. The source of the animal or plant oil and the biomass may be the same renewable source. |
| FILED | Monday, April 06, 2009 |
| APPL NO | 12/418994 |
| ART UNIT | 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemistry of hydrocarbon compounds 585/240 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324554 | Shaver et al. |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | David C. Shaver (Carlisle, Massachusetts); Bernard B. Kosicki (Acton, Massachusetts); Robert K. Reich (Tyngsboro, Massachusetts); Dennis D Rathman (Ashland, Massachusetts); Daniel R. Schuette (Arlington, Massachusetts); Brian F. Aull (Cambridge, Massachusetts) |
| ABSTRACT | Embodiments of the present invention include an electron counter with a charge-coupled device (CCD) register configured to transfer electrons to a Geiger-mode avalanche diode (GM-AD) array operably coupled to the output of the CCD register. At high charge levels, a nondestructive amplifier senses the charge at the CCD register output to provide an analog indication of the charge. At low charge levels, noiseless charge splitters or meters divide the charge into single-electron packets, each of which is detected by a GM-AD that provides a digital output indicating whether an electron is present. Example electron counters are particularly well suited for counting photoelectrons generated by large-format, high-speed imaging arrays because they operate with high dynamic range and high sensitivity. As a result, they can be used to image scenes over a wide range of light levels. |
| FILED | Tuesday, March 23, 2010 |
| APPL NO | 12/730037 |
| ART UNIT | 2878 — Optics |
| CURRENT CPC | Radiant energy 250/214.R00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324563 | Broyles et al. |
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| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Michael J. Broyles (Tucson, Arizona); Terry M. Sanderson (Tucson, Arizona); Douglas M. Beard (Tucson, Arizona); Brian D. Alfing (Tucson, Arizona) |
| ABSTRACT | A container includes a housing and a cover which may be wholly or partially removed to open the container. A foil seal is used to seal the joint between the housing and the cover. The foil seal is internal to the container. The foil seal separates during opening of the cover, respective parts of the foil seal remaining with the housing and the cover. The foil seal may be a metal or metal-containing foil, for example being an aluminum, steel, or titanium foil, or a metalized plastic foil. A cutter, such as a serrated edge, may be positioned to facilitate cutting of the foil seal during cover opening. The container may be part of a seeker assembly with the housing being a seeker housing, and the cover being a removable or hinged cover that protects an optical seeker during some portions of flight, such as during launch of a spacecraft. |
| FILED | Thursday, April 01, 2010 |
| APPL NO | 12/752221 |
| ART UNIT | 2878 — Optics |
| CURRENT CPC | Radiant energy 250/239 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324564 | Pinkus et al. |
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| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented, by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Alan R. Pinkus (Bellbrook, Ohio); Harry L. Task (Tucson, Arizona); Sheldon E. Unger (Englewood, Ohio) |
| ABSTRACT | A quad-emissive display apparatus to provide suitable emissive energy in four spectral bands to provide simultaneous evaluation of sensors having different spectral sensitivities. The apparatus can simultaneously provide four spectral bands of visible (0.4 to 0.7 microns), near infrared (0.7 to 1.0 microns), short wave infrared (1.0 to 3.0 microns) and the long wave infrared (8.0 to 14.0 microns) radiation. |
| FILED | Wednesday, March 10, 2010 |
| APPL NO | 12/720920 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Radiant energy 250/252.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324588 | Dunn |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| INVENTOR(S) | William L. Dunn (Manhattan, Kansas) |
| ABSTRACT | A detection system and methods are described for determining whether a target contains a selected substance or device such as an explosive device, illegal drugs, dangerous chemicals, or the like. According to some embodiments, a detection system is comprising a radiation source and one or more detectors. The detection system in this directs radiation from a distance and towards a target suspected to contain a dangerous device or substance. A response is detected from the target. The response is compared to one or more templates that represent known explosives, drugs, dangerous chemicals, or the like. A score may be generated that corresponds to a similarity between the targeted and known substances. When the score indicates that the target substance is likely to be dangerous or contraband, then an alarm or other indication may be generated in some embodiments. |
| FILED | Thursday, September 11, 2008 |
| APPL NO | 12/209063 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Radiant energy 250/390.40 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324785 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ya-Mei Chen (Berkeley, California); Michael Stephen Sheppy (Alameda, California); Matthew A. Hopcroft (San Francisco, California); Albert P. Pisano (Danville, California); Rajesh Vinodrai Mehta (Rochester, New York); Michael Alan Marcus (Honeoye Falls, New York); Gilbert Allan Hawkins (Mendon, New York) |
| ABSTRACT | Piezoelectric actuators are provided. In some instances, the piezoelectric actuators are high-precision piezoelectric actuators. The piezoelectric beams may have a bi-chevron configuration. Also provided are methods of making the piezoelectric actuators, e.g., using Micro-Electro-Mechanical System (MEMS) fabrication techniques, and methods of using the piezoelectric actuators, e.g., as valves in fluid dispensing systems. |
| FILED | Tuesday, November 10, 2009 |
| APPL NO | 12/615826 |
| ART UNIT | 2837 — Electrical Circuits and Systems |
| CURRENT CPC | Electrical generator or motor structure 310/328 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324803 | Forrest et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan); Mark E. Thompson (Anaheim, California); Paul E. Burrows (Kennewick, Washington); Linda Susan Sapochak (Arlington, Virginia); Dennis Matthew McCarty (Pennsauken, New Jersey) |
| ABSTRACT | A multicolor organic light emitting device employs vertically stacked layers of double heterostructure devices which are fabricated from organic compounds. The vertical stacked structure is formed on a glass base having a transparent coating of ITO or similar metal to provide a substrate. Deposited on the substrate is the vertical stacked arrangement of three double heterostructure devices, each fabricated from a suitable organic material. Stacking is implemented such that the double heterostructure with the longest wavelength is on the top of the stack. This constitutes the device emitting red light on the top with the device having the shortest wavelength, namely, the device emitting blue light, on the bottom of the stack. Located between the red and blue device structures is the green device structure. The devices are configured as stacked to provide a staircase profile whereby each device is separated from the other by a thin transparent conductive contact layer to enable light emanating from each of the devices to pass through the semitransparent contacts and through the lower device structures while further enabling each of the devices to receive a selective bias. The devices are substantially transparent when de-energized, making them useful for heads-up display applications. |
| FILED | Tuesday, April 06, 2010 |
| APPL NO | 12/755159 |
| ART UNIT | 2889 — Electrical Circuits and Systems |
| CURRENT CPC | Electric lamp and discharge devices 313/504 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324811 | Fuks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | STC.UNM (Albuquerque, New Mexico) |
| INVENTOR(S) | Mikhail Fuks (Albuquerque, New Mexico); Edl Schamiloglu (Albuquerque, New Mexico) |
| ABSTRACT | A cathode for use in a magnetron may include a plurality of longitudinally oriented emitter regions disposed around a longitudinal axis of the cathode. Each emitter region can be configured to emit electrons and adjacent emitter regions can be separated from one another by openings. The emitter regions can be configured to promote simultaneous cathode priming, magnetic priming, and electrostatic priming. |
| FILED | Monday, February 22, 2010 |
| APPL NO | 12/710041 |
| ART UNIT | 2821 — Electrical Circuits and Systems |
| CURRENT CPC | Electric lamp and discharge devices: Systems 315/39.510 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324951 | Zarkesh-Ha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | STC.UNM (Albuquerque, New Mexico) |
| INVENTOR(S) | Payman Zarkesh-Ha (Albuquerque, New Mexico); Vallabh Srikanth Devarapalli (Albuquerque, New Mexico); Steven C. Suddarth (Albuquerque, New Mexico) |
| ABSTRACT | A dual data rate flip-flop circuit for reducing single event upset errors in the flip-flop circuit including two or more latch circuits connected in parallel. The latch circuits each have a clock input, data input, and latch circuit output. The dual data rate flip-flop circuit also includes a C-element, which has a plurality of inputs and a C-element output. The outputs of the latch circuits are provided to inputs of the C-element, and a keeper circuit is connected to the C-element output. An output buffer inverter connects to the C-element output and has an output corresponding to the dual data rate flip-flop circuit output. |
| FILED | Friday, April 08, 2011 |
| APPL NO | 13/082826 |
| ART UNIT | 2816 — Semiconductors/Memory |
| CURRENT CPC | Miscellaneous active electrical nonlinear devices, circuits, and systems 327/206 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324976 | Borghetti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Hewlett-Packard Development Company, L.P. (Houston, Texas) |
| INVENTOR(S) | Julien Borghetti (Mountain View, California); Matthew D Pickett (San Francisco, California); Gilberto Medeiros Ribeiro (Palo Alto, California); Wei Yi (Mountain View, California); Jianhua Yang (Palo Alto, California); Minxian Max Zhang (Mountain View, California) |
| ABSTRACT | Circuitry is provided that closely emulates biological neural responses. Two astable multivibrator circuits (AMCs), each including a negative differential resistance device, are coupled in series-circuit relationship. Each AMC is characterized by a distinct voltage-dependant time constant. The circuitry exhibits oscillations in electrical current when subjected to a voltage equal to or greater than a threshold value. Various oscillating waveforms can be produced in accordance with voltages applied to the circuitry. |
| FILED | Friday, April 01, 2011 |
| APPL NO | 13/078595 |
| ART UNIT | 2817 — Semiconductors/Memory |
| CURRENT CPC | Oscillators 331/107.R00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325001 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daquan Huang (Santa Monica, California); Mau-Chung Frank Chang (Los Angeles, California) |
| ABSTRACT | Interleaved three-dimensional (3D) on-chip differential inductors 110, 120 and transformer 100 are disclosed. The interleaved 3D on-chip differential inductors 110, 120 and transformer 100 make the best use of multiple metal layers in mainstream standard processes, such as CMOS, BiCMOS and SiGe technologies. |
| FILED | Wednesday, August 02, 2006 |
| APPL NO | 11/908603 |
| ART UNIT | 2832 — Semiconductors/Memory |
| CURRENT CPC | Inductor devices 336/200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325030 | Townsend et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Lord Corporation (Cary, North Carolina) |
| INVENTOR(S) | Christopher P. Townsend (Shelburne, Vermont); Steven W. Arms (Williston, Vermont); David L. Churchill (Burlington, Vermont); Jacob H. Galbreath (Burlington, Vermont) |
| ABSTRACT | One embodiment of an electronic system includes a network having a first sensing device with a first address and a second sensing device with a second address. The first sensing device includes first sensors, a first processor, a first memory, and a first communications device. The first sensors include a first dry bulb temperature sensor, a first relative humidity sensor, and a first radiant energy sensor. The second sensing device includes a second sensor, a second processor, a second memory, and a second communications device. The second processor includes a program to use the second communications device to communicate the second address and data derived from the second sensor to the first communications device. |
| FILED | Friday, September 07, 2007 |
| APPL NO | 11/899840 |
| ART UNIT | 2612 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Communications: Electrical 340/539.110 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325093 | Holland et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Steven S. Holland (Amherst, Massachusetts); Marinos N. Vouvakis (Amherst, Massachusetts) |
| ABSTRACT | A planar ultrawideband modular antenna for connection to a feed network. The antenna has a ground plane, and an array of antenna elements spaced from the ground plane, each antenna element comprising a pair of arms. A first fed arm is electrically coupled to the feed network. The grounded arm is directly electrically coupled to the ground plane. There are one or more conductors such as conductive vias electrically connecting the fed arm to the ground plane, and optionally there are one or more additional conductors electrically connecting the grounded arm to the ground plane. |
| FILED | Monday, August 02, 2010 |
| APPL NO | 12/848301 |
| ART UNIT | 2821 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Communications: Radio wave antennas 343/700.MS0 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325098 | Henrie |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Justin Henrie (Camarillo, California) |
| ABSTRACT | A dynamic antenna pattern measurement method. Embodiments of the invention provide for nanosecond or better time resolution and milliradian angular resolution of the dynamic radiation pattern of an antenna under test over the predetermined solid angle scan (up to 4π steradians) of the dynamic radiation pattern. |
| FILED | Thursday, April 29, 2010 |
| APPL NO | 12/770311 |
| ART UNIT | 2821 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Communications: Radio wave antennas 343/703 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325099 | Cavener et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Ronni J. Cavener (Haverhill, Massachusetts); Robert V. Cummings (Anacortes, Washington) |
| ABSTRACT | Methods and apparatus for a coincident phase center dual polarized slotline radiator. In one embodiment, a radiator includes, for each of two polarizations in a unit cell: first and second fins to provide an air transition for a signal, the radiator including a throat region between the first and second fins, a microstrip path transitioning to a slotline feed, a slotline split forming a part of the slotline feed to provide signal power division and 180 degree phase shift for rejoinder in the throat of the radiator to launch the signal into free space. In another embodiment, a four port radiator is provided. |
| FILED | Tuesday, December 22, 2009 |
| APPL NO | 12/644288 |
| ART UNIT | 2821 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Communications: Radio wave antennas 343/770 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325178 | Doyle, Jr. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Robert J Doyle, Jr. (Alexandria, Virginia) |
| ABSTRACT | A method for processing three-dimensional data that defines a three-dimensional scene, and determining and displaying lines-of-sight (LOS) and viewsheds on all visible surfaces of the scene, includes: i) assigning at a user-selected location at least one viewpoint in the scene; ii) applying ray tracing from locations in the scene to the viewpoint to determine locations in the scene that are in a line of sight (LOS) and outside the LOS of the viewpoint, thus determining the viewshed relative to the viewpoint; and iii) color-coding every visible surface in the scene. The color coding then differentially indicates the locations in the line of sight (LOS) and outside the LOS of the viewpoint, producing a display of a color-coded viewshed relative to the viewpoint. Additionally ray tracing can be applied from locations above the scene to determine headroom contours for those locations in the scene. |
| FILED | Wednesday, November 26, 2008 |
| APPL NO | 12/292786 |
| ART UNIT | 2628 — Selective Visual Display Systems |
| CURRENT CPC | Computer graphics processing and selective visual display systems 345/419 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325349 | Cui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Xiquan Cui (Pasadena, California); Lap Man Lee (Arcadia, California); Changhuei Yang (Pasadena, California) |
| ABSTRACT | Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique that may be used employs surface tension at a hydrophobic surface to passively pump the fluid sample through the fluid channel. Another technique uses electrodes to adjust the position of objects in the fluid channel. Another technique computationally adjusts the focal plane of an image wavefront measured using differential interference contrast (DIC) based on Young's interference by back propagating the image wavefront from the detection focal plane to a different focal plane. These techniques can be employed separately or in combination to improve the capabilities of OFM devices. |
| FILED | Tuesday, December 15, 2009 |
| APPL NO | 12/638518 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/515 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325402 | Blanche et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | TIPD, LLC (Tucson, Arizona); The Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Pierre-Alexandre Jean Blanche (Tucson, Arizona); Arkady Bablumyan (San Diego, California); Nasser N. Peyghambarian (Tucson, Arizona) |
| ABSTRACT | A system and method that synchronizes a spatial light modulator (SLM) with a pulsed laser to record a hologram at the repetition rate of the pulsed laser for applications including holographic displays and data storage. The color channel capability of a SLM is utilized to effectively increase the write throughput when the pulsed laser repetition rate LR exceeds the SLM's image refresh rate R. The hogels are encoded on the color channels and concatenated to form a sequence of color images such that the write throughput is equal to the repetition rate LR up to a maximum of N*R. This effectively extends the capability and continued viability of existing inexpensive SLMs. |
| FILED | Monday, February 15, 2010 |
| APPL NO | 12/705897 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical: Systems and elements 359/21 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325411 | Higginson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Triton Systems, Inc. (Chelmsford, Massachusetts) |
| INVENTOR(S) | Keith A. Higginson (Leominster, Massachusetts); Alkim Akyurtlu (Arlington, Massachusetts); Adil-Gerai Kussow (Beverly, Massachusetts) |
| ABSTRACT | Embodiments of the invention described herein include metamaterials that exhibit negative permittivity and negative permeability at optical frequencies, methods for preparing such materials, and devices prepared from same. |
| FILED | Wednesday, November 25, 2009 |
| APPL NO | 12/626173 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical: Systems and elements 359/315 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325417 | Kurti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Ralph Steven Kurti (Ridgecrest, California); Michael Johnny Wardlaw (King George, Virginia); Ramesh Kumar Shori (Burbank, California) |
| ABSTRACT | A phased array of Gaussian beams was used to form an annular far-field pattern as opposed to the normal peaked pattern in most phased arrays. This annular pattern arises from the radial symmetry of the polarization in each beam. Beams opposite one another in the annulus are polarized in the same direction but are 180° out of phase. This causes the center portion of the beam to be a null rather than a peak. |
| FILED | Tuesday, September 23, 2008 |
| APPL NO | 12/164530 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical: Systems and elements 359/483.10 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325420 | Liau |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Zong-Long Liau (Belmont, Massachusetts) |
| ABSTRACT | A sub-millimeter solid immersion lens (SIL), comprises a body of a high-index material transparent to electromagnetic radiation in a frequency band to be observed, the body having a flat bottom surface which receives an object to be observed, and the body further having a first upper surface whose limits approximate a zone of a spherical segment and a second upper surface defined by an upper bound of the zone of the spherical segment which prevents passage of electromagnetic radiation in the frequency band to be observed. The SIL may be incorporated into an array, according to other aspects. A method of making a SIL comprises: providing a substrate layer of a high-index material transparent to electromagnetic radiation in a frequency band to be observed, having a lower surface through which an object is observed; etching a surface of the substrate layer to form a first upper surface whose limits approximate a zone of a spherical segment; etching a surface of the substrate layer to form a second upper surface; treating the second upper surface to prevent transmission of the electromagnetic radiation in the frequency band to be observed; and treating the lower surface to absorb electromagnetic radiation in the frequency band to be observed, leaving untreated a hole defined therein to form a sampling port at which the object is positioned. |
| FILED | Monday, November 22, 2010 |
| APPL NO | 12/952170 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical: Systems and elements 359/661 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325461 | Dolfi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Rockford, Illinois) |
| INVENTOR(S) | Eugene W. Dolfi (Rockford, Illinois); Mark W. Metzler (Davis, Illinois); Mark C. Lukan (Rockford, Illinois); Eric A. Carter (Monroe, Wisconsin) |
| ABSTRACT | A feed-through capacitor is constructed in a printed wiring board using alternating layers of metal capacitive layers and plastic dielectric layers of the printed wiring board. The large number of layers, the avoidance of ceramic layers and the flexible geometry of this device allow it to be used in many applications, particularly in those involving high power high current. Also, because it utilizes a printed wiring board, the capacitor can be made in numerous sizes and shapes. |
| FILED | Friday, August 08, 2008 |
| APPL NO | 12/188457 |
| ART UNIT | 2835 — Electrical Circuits and Systems |
| CURRENT CPC | Electricity: Electrical systems and devices 361/302 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325564 | Ruffa |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Anthony A. Ruffa (Hope Valley, Rhode Island) |
| ABSTRACT | An acoustic source for use in a saltwater environment includes a transducer for projecting acoustic energy. The transducer is positioned within a semi-permeable membrane. The volume around the transducer within the membrane is filled with water having a lower concentration of a solute such as salt. When positioned in the saltwater environment, an osmotic pressure is created within the membrane. This osmotic pressure acts to suppress cavitation such as that which could be generated by the transducer. In further embodiments a support structure is used to support the membrane and the transducer could be an array of transducers. |
| FILED | Tuesday, July 27, 2010 |
| APPL NO | 12/844304 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Communications, electrical: Acoustic wave systems and devices 367/171 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325746 | Somasundaram et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland) |
| INVENTOR(S) | Kiran K. Somasundaram (Greenbelt, Maryland); Kaustubh Jain (College Park, Maryland); Vahid Tabatabaee (Gaithersburg, Maryland); John S. Baras (Potomac, Maryland) |
| ABSTRACT | An apparatus and method are provided for optimizing the link-state information that is to be broadcast in a routing domain of a communication network for QoS rule-based link-state routing. The routers include any device capable of implementing the routing primitives. The apparatus and method involve pruning the link-state information using local neighborhood information that has been discovered. The local link-state is pruned so that the QoS optimal paths are preserved for link-state routing. Pruning of the potential optimal paths is carried out to minimize the information broadcast to the intra domain routers in an autonomous system/routing domain. The apparatus and method also involve broadcasting the selected link-state information. |
| FILED | Friday, October 08, 2010 |
| APPL NO | 12/923812 |
| ART UNIT | 2465 — Multiplex and VoIP |
| CURRENT CPC | Multiplex communications 370/401 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325776 | Conway et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Joshua A. Conway (Redondo Beach, California); Jon V. Osborn (Thousand Oaks, California); Ryan A. Stevenson (Maple Valley, Washington) |
| ABSTRACT | A device having a light cavity includes, at one end, a plasmonic reflector having a grating surface for coupling incoming light into traverse plasmon waves and for coupling the traverse plasmon wave into broaden light, the surface serving to redistribute light within the cavity, the reflector being well suited for use in laser diodes for redistributing filamental cavity laser light into spatially broaden cavity laser light for translating multimodal laser light into unimodal laser light for improved reliability and uniform laser beam creation. |
| FILED | Friday, July 22, 2011 |
| APPL NO | 13/189412 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Coherent light generators 372/49.10 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326081 | Rikoski |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Richard Rikoski (Alameda, California) |
| ABSTRACT | A correlation image detector is provided that co-registers sonar images by finding peaks in correlation images. To obtain the peaks, the mean of the absolute values of the correlation coefficients in the correlation image is found and the Rayleigh parameter is determined from the mean. Based on the Rayleigh parameter, an appropriate threshold can be determined using a desired probability of false detection. The threshold can be chosen such that the probability of a single false detection over the expected life of the mission for which correlation detection is being performed is extremely low, e.g., one in a million. The peak value in the image is determined and a correlation is considered detected when the peak value is greater than the product of the threshold and the Rayleigh parameter. If a detection occurs, the correlation image detector returns the transformation that co-registers the two images. |
| FILED | Monday, May 18, 2009 |
| APPL NO | 12/454484 |
| ART UNIT | 2624 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/278 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326088 | Repperger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Daniel W. Repperger (Dayton, Ohio); Rodney G. Roberts (Tallahassee, Florida); Alan R. Pinkus (Bellbrook, Ohio); Robert D. Sorkin (St. Augustine, Florida) |
| ABSTRACT | A method for registering and fusing time-varying image sources to provide highest possible information rendering to an operator comprising the steps of aligning a plurality of image sources by matching target image to a reference image and minimizing visual registration error in a static sense and selecting target images which are best fused with a reference image using a dynamic, time-varying optimality maximum likelihood decision theory. The maximum likelihood decision theory is modified to account for time-varying using an orthogonal projection technique charactering changing density functions. |
| FILED | Tuesday, May 26, 2009 |
| APPL NO | 12/471543 |
| ART UNIT | 2624 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/294 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326313 | McHenry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Shared Spectrum Company (Vienna, Virginia) |
| INVENTOR(S) | Mark Allen McHenry (McLean, Virginia); Igor Anatoly Bazarov (Herndon, Virginia); Dmitry Dain (Herndon, Virginia); Jevgenijs Livsics (Reston, Virginia); Filip Perich (Annapolis, Maryland); Olga K. Ritterbush (Arlington, Virginia); Karl N. Steadman (Arlington, Virginia) |
| ABSTRACT | Methods and systems for dynamic spectrum access (DSA) in a wireless network are provided. A DSA-enabled device may sense spectrum use in a region and, based on the detected spectrum use, select one or more communication channels for use. The devices also may detect one or more other DSA-enabled devices with which they can form DSA networks. A DSA network may monitor spectrum use by cooperative and non-cooperative devices, to dynamically select one or more channels to use for communication while avoiding or reducing interference with other devices. |
| FILED | Friday, August 14, 2009 |
| APPL NO | 12/541621 |
| ART UNIT | 2617 — Selective Visual Display Systems |
| CURRENT CPC | Telecommunications 455/454 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326461 | Zirkind et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Naomi Zirkind (Morristown, New Jersey); Joshua Lee (Pine Brook, New Jersey) |
| ABSTRACT | A system for providing autonomous capabilities to a radio-controlled robot, comprises two communication boxes, one connected to the robot and the other connected to an operator control unit (OCU). Each communication box comprises two radios that are interoperable with preexisting data radios in the robot; a microprocessor unit; and bidirectional attenuators. The system further comprises a software application that runs on the microprocessor unit of each communications box, to integrate data into existing transmission data stream between the robot and OCU, via preexisting data radios. The system enables the issuance of additional commands besides those issued by the OCU, using the original OCU. |
| FILED | Friday, October 10, 2008 |
| APPL NO | 12/249013 |
| ART UNIT | 3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Data processing: Generic control systems or specific applications 7/264 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326579 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Perry W. Wilson (Laurel, Maryland); J. Aaron Pendergrass (Silver Spring, Maryland); C. Durward McDonell, III (Olney, Maryland); Peter A. Loscocco (Glenwood, Maryland); David J. Heine (Columbia, Maryland); Bessie Y. Lewis (Owings Mills, Maryland) |
| ABSTRACT | The present disclosure is directed towards methods and systems and methods for measuring the integrity of an operating system's execution and ensuring that the system's code is performing its intended functionality. This includes examining the integrity of the code that the operating system is executing as well as the data that the operating system accesses. Integrity violations can be detected in the dynamic portions of the code being executed. |
| FILED | Friday, March 04, 2011 |
| APPL NO | 13/040622 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/186 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326585 | Cler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Daniel L. Cler (Coatesville, Pennsylvania); Mark A. Doxbeck (Troy, New York) |
| ABSTRACT | A method for identifying a shock wave includes creating a grid comprising cells; sorting the cells based on their pressure gradients; and sorting the cells based on a negative dot product of their pressure gradients and their velocity vectors divided by the velocity of sound. The number of cells that are refined may be reduced by sorting the cells based on their distances from a shock wave center, and/or sorting the cells based on their mass fractions of a species. A buffer zone of refined cells may be created in front of the shock wave. |
| FILED | Monday, June 16, 2008 |
| APPL NO | 12/139586 |
| ART UNIT | 2123 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Structural design, modeling, simulation, and emulation 73/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326782 | Snook et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Neurosciences Research Foundation, Inc. (San Diego, California) |
| INVENTOR(S) | James A. Snook (San Diego, California); Richard W. Schermerhorn (Cardiff, California) |
| ABSTRACT | A special purpose processor (SPP) can use a Field Programmable Gate Array (FPGA) to model a large number of neural elements. The FPGAs or similar programmable device can have multiple cores doing presynaptic, postsynaptic, and plasticity calculations in parallel. Each core can implement multiple neural elements of the neural model. |
| FILED | Monday, March 14, 2011 |
| APPL NO | 13/047434 |
| ART UNIT | 2129 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Artificial intelligence 76/33 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326895 | Fink et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Stephen J Fink (Yorktown Heights, New York); David P. Grove (Ridgefield, Connecticut) |
| ABSTRACT | A computer readable storage medium for associating a phase with an activation of a computer program that supports garbage collection include: a plurality of stacks, each stack including at least one stack frame that includes an activation count; and a processor with logic for performing steps of: zeroing the activation count whenever the program creates a new stack frame and after garbage collection is performed; determining whether an interval has transpired during program execution; examining each stack frame's content and incrementing the activation count for each frame of the stacks once the interval has transpired; detecting the phase whose activation count is non-zero and associating the phase with the activation; and ensuring that when the phase ends, an action is immediately performed. |
| FILED | Saturday, May 22, 2010 |
| APPL NO | 12/785436 |
| ART UNIT | 2163 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/813 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08327072 | Guthrie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Guy L. Guthrie (Austin, Texas); Thomas L. Jeremiah (Hillsborough, North Carolina); William J. Starke (Round Rock, Texas); Phillip G. Williams (Leander, Texas) |
| ABSTRACT | A data processing system includes a processor core having an associated upper level cache and a lower level victim cache. In response to a memory access request of the processor core, the lower level cache victim determines whether the memory access request hits or misses in the directory of the lower level victim cache, and the upper level cache determines whether a castout from the upper level cache is to be performed and selects a victim coherency granule for eviction from the upper level cache. In response to determining that a castout from the upper level cache is to be performed, the upper level cache evicts the selected victim coherency granule. In the eviction, the upper level cache reads out the victim coherency granule from the data array of the upper level cache only in response to an indication that the memory access request misses in the directory of the lower level victim cache. |
| FILED | Wednesday, July 23, 2008 |
| APPL NO | 12/177912 |
| ART UNIT | 2189 — Data Bases & File Management |
| CURRENT CPC | Electrical computers and digital processing systems: Memory 711/122 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08327073 | Guthrie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Guy L. Guthrie (Austin, Texas); Harmony L. Helterhoff (Austin, Texas); Thomas L. Jeremiah (Hillsborough, North Carolina); Alvan W. Ng (Austin, Texas); William J. Starke (Round Rock, Texas); Jeffrey A. Stuecheli (Austin, Texas); Philip G. Williams (Leander, Texas) |
| ABSTRACT | A second lower level cache receives an LCO command issued by a first lower level cache on an interconnect fabric. The LCO command indicates an address of a victim cache line to be castout from the first lower level cache and indicates that the second lower level cache is an intended destination of the victim cache line. The second lower level cache determines whether to accept the victim cache line from the first lower level cache based at least in part on the address of the victim cache line indicated by the LCO command. In response to determining not to accept the victim cache line, the second lower level cache provides a coherence response to the LCO command refusing the identified victim cache line. In response to determining to accept the victim cache line, the second lower level cache updates an entry corresponding to the identified victim cache line. |
| FILED | Thursday, April 09, 2009 |
| APPL NO | 12/421017 |
| ART UNIT | 2185 — Computer Architecture and I/O |
| CURRENT CPC | Electrical computers and digital processing systems: Memory 711/122 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08327101 | Arimilli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Ravi K. Arimilli (Austin, Texas); Robert S. Blackmore (Poughkeepsie, New York); Chulho Kim (Poughkeepsie, New York); Balaram Sinharoy (Poughkeepsie, New York); Hanhong Xue (Poughkeepsie, New York) |
| ABSTRACT | A data processing system includes a mechanism for completing an asynchronous memory move (AMM) operation in which the processor receives an AMM ST instruction and processes a processor-level move of data in virtual address space and an asynchronous memory mover then completes a physical move of the data within the real address space (memory). A status/control field of the AMM ST instruction includes an indication of a requested treatment of the lower level cache(s) on completion of the AMM operation. When the status/control field indicates an update to at least one cache should be performed, the asynchronous memory mover automatically forwards a copy of the data from the data move to the lower level cache, and triggers an update of a coherency state for a cache line in which the copy of the data is placed. |
| FILED | Friday, February 01, 2008 |
| APPL NO | 12/024526 |
| ART UNIT | 2186 — Computer Architecture and I/O |
| CURRENT CPC | Electrical computers and digital processing systems: Memory 711/165 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08327325 | Chung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | I-Hsin Chung (Yorktown Heights, New York); Guojing Cong (Ossining, New York); David J. Klepacki (New Paltz, New York); Simone Sbaraglia (Cagliari, Italy); Seetharami R. Seelam (Yorktown Heights, New York); Hui-Fang Wen (Yorktown Heights, New York) |
| ABSTRACT | A target application is automatically tuned. A list of solutions for identified performance bottlenecks in a target application is retrieved from a storage device. A plurality of modules is executed to compute specific parameters for solutions contained in the list of solutions. A list of modification commands associated with specific parameters computed by the plurality of modules is generated. The list of modification commands associated with the specific parameters is appended to a command sequence list. The list of modification commands is implemented in the target application. Specific source code regions corresponding to the identified performance bottlenecks in the target application are automatically tuned using the implemented list of modification commands. Then, the tuned target application is stored in the storage device. |
| FILED | Wednesday, January 14, 2009 |
| APPL NO | 12/353433 |
| ART UNIT | 2192 — Interprocess Communication and Software Development |
| CURRENT CPC | Data processing: Software development, installation, and management 717/110 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08327327 | Bierhoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Kevin M. Bierhoff (Pittsburgh, Pennsylvania); Jonathan Aldrich (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method for statically checking an object-oriented computer program module includes the step of identifying objects within a computer program module, at least one of the objects having a plurality of references thereto, possibly from multiple clients. A discipline of permissions is imposed on the objects identified within the computer program module. The permissions enable tracking, from among a discrete set of changeable states, a subset of states each object might be in. A determination is made regarding whether the imposed permissions are violated by a potential reference to any of the identified objects. The results of the determination are output to a user. |
| FILED | Friday, March 21, 2008 |
| APPL NO | 12/077830 |
| ART UNIT | 2191 — Interprocess Communication and Software Development |
| CURRENT CPC | Data processing: Software development, installation, and management 717/116 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US H2273 | Nechitailo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Nicholas V. Nechitailo (Mechanicsville, Virginia) |
| ABSTRACT | A particulate filter is provided for passing through select permeate particles in a fluid medium from inflow to outflow regions while restraining reticulate particles. The filter includes a coarse-grain ceramic porous substrate, an intermediate-grain porous ceramic layer, a fine-grain ceramic porous membrane, and a channel there-through. The substrate opens into the outflow region as an outflow cavity. The intermediate-grain porous ceramic layer is disposed on the substrate. The fine-grain ceramic porous membrane is disposed on the layer and opens into the inflow region containing the medium as an inflow cavity. The channel directionally expands and connects the inflow and outflow cavities together by a substantially funnel-shape passage. The inflow cavity permits the permeate particles and the medium but obstructs the reticulate particles. Additionally, a method is provided for producing a particulate filter that passes through select permeate particles in a fluid medium from inflow to outflow regions while restraining reticulate particles. The method includes providing an aluminum oxide substrate, disposing a sol-gel membrane onto the substrate to form a filtration unit, drying the filtration unit, and calcinating the filtration unit. |
| FILED | Wednesday, June 30, 2010 |
| APPL NO | 12/804605 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Liquid purification or separation 210/500.210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Health and Human Services (HHS)
| US 08322027 | Greenberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Second Sight Medical Products, Inc. (Sylmar, California) |
| INVENTOR(S) | Robert J. Greenberg (Los Angeles, California); Neil Hamilton Talbot (Montrose, California); Jordan Matthew Neysmith (Pasadena, California); Jerry Ok (Canyon Country, California) |
| ABSTRACT | A method for manufacturing a flexible circuit electrode array, comprising: a) depositing a metal trace layer containing a base coating layer, a conducting layer and a top coating layer on said insulator polymer base layer; b) applying a layer of photoresist on said metal trace layer and patterning said metal trace layer and forming metal traces on said insulator polymer base layer; c) activating said insulator polymer base layer and depositing a top insulator polymer layer and forming one single insulating polymer layer with said base insulator polymer layer; d) applying a thin metal layer and a layer of photoresist on the surface of said insulator polymer layer and selective etching said insulator layer and said top coating layer to obtain at least one via; and e) filling said via with electrode material. A layer of polymer is laid down. A layer of metal is applied to the polymer and patterned to create electrodes and leads for those electrodes. A second layer of polymer is applied over the metal layer and patterned to leave openings for the electrodes, or openings are created later by means such as laser ablation. Hence the array and its supply cable are formed of a single body. Alternatively, multiple alternating layers of metal and polymer may be applied to obtain more metal traces within a given width. The method provides an excellent adhesion between the polymer base layer and the polymer top layer and insulation of the trace metals and electrodes. |
| FILED | Monday, October 29, 2007 |
| APPL NO | 11/926498 |
| ART UNIT | 3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Metal working 029/829 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322310 | Chiodo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chris D. Chiodo (Warren, Michigan) |
| ABSTRACT | A laboratory specimen, such as a mouse or rat, can be accurately and repeatedly imaged in an imaging machine, such as an MRI machine, when securely positioned on a specimen support bed. The support bed includes contours and accessories for centering a specimen on the support bed. One or more bite bars coact with a head clamp to accurately fix a specimen's head in the same position time after time. |
| FILED | Monday, March 31, 2008 |
| APPL NO | 12/079890 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Animal husbandry 119/755 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323199 | Salcudean et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The University of British Columbia (Vancouver, Canada) |
| INVENTOR(S) | Septimiu Edmund Salcudean (Vancouver, Canada); Reza Zahiri-Azar (Vancouver, Canada); Danny French (Vancouver, Canada); Xu Wen (Vancouver, Canada) |
| ABSTRACT | The present invention relates to a method and apparatus for imaging the mechanical properties of a tissue region from within an endocavity of a patient. The apparatus generally comprises an ultrasound probe, a vibration assembly translationally coupled to probe and operable to vibrate the probe along a vibration plane, and a rotation assembly rotationally coupled to the vibration assembly and operable to rotate the probe and vibration assembly about a selected rotational range. The method generally comprises inserting an ultrasound probe into an endocavity of a patient, vibrating the probe along a vibration plane thereby causing deformational excitement of a tissue region contacted by the probe, capturing a first series of ultrasound images of the tissue region, rotating the vibration plane relative to the tissue region by a selected angular rotation, and capturing a second series of ultrasound images of the tissue region. |
| FILED | Monday, September 29, 2008 |
| APPL NO | 12/240895 |
| ART UNIT | 3768 — Amusement and Education Devices |
| CURRENT CPC | Surgery 6/445 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323276 | Palanker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Daniel V. Palanker (Sunnyvale, California); Alexander B. Vankov (Menlo Park, California) |
| ABSTRACT | Described herein are methods and apparatus for cutting a material including biological tissue. The apparatus has a cutting electrode with an elongate cutting portion. A voltage pulse waveform (typically comprising repeated bursts of minipulses) having a low or very low duty-cycle is applied to the cutting electrode to cut the tissue or other material by producing a vapor cavity around the cutting portion of the electrode and ionizing a gas inside the vapor cavity to produce a plasma. A low duty cycle cutting waveform may prevent heat accumulation in the tissue, reducing collateral thermal damage. The duration of the burst of minipulses typically ranges from 10 μs to 100 μs, and the rep rate typically ranges from 1 KHz to 10 Hz, as necessary. The apparatus and method of invention may cut biological tissue while decreasing bleeding and maintaining a very shallow zone of thermal damage. |
| FILED | Wednesday, June 22, 2011 |
| APPL NO | 13/166690 |
| ART UNIT | 3739 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery 66/34 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323488 | Tai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); City of Hope (Duarte, California) |
| INVENTOR(S) | Yu-Chong Tai (Pasadena, California); Qing He (Rancho Palos Verdes, California); Jun Xie (Niskayuna, New York); Changlin Pang (Pasadena, California); Terry D. Lee (San Dimas, California); Damien Rodger (South Pasadena, California); Matthieu Liger (San Francisco, California) |
| ABSTRACT | Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC. |
| FILED | Monday, February 28, 2011 |
| APPL NO | 13/037192 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Liquid purification or separation 210/198.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323643 | Badalamente et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Research Foundation of State University of New York (Albany, New York) |
| INVENTOR(S) | Marie A. Badalamente (Mt. Sinai, New York); Edward Wang (Poluott, New York) |
| ABSTRACT | The invention relates to the discovery that collagenase injections are effective in lyse the collagenous adhesions in the shoulder and treat the disorder, adhesive capsulitis. As such, the invention relates to methods of treating or preventing adhesive capsulitis, or frozen shoulder, in a patient in need of such treatment comprising injecting or otherwise delivering an effective amount of collagenase to the collagenous adhesions in the shoulder. The invention also relates to the use of collagenase in the manufacture of a medicament to treat adhesive capsulitis. |
| FILED | Thursday, November 06, 2008 |
| APPL NO | 12/266090 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/94.670 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323668 | Fleckenstein |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The University of Tennessee Research Foundation (Knoxville, Tennessee) |
| INVENTOR(S) | James M. Fleckenstein (Memphis, Tennessee) |
| ABSTRACT | The present invention describes a novel mechanism of adhesion by flagellated Gram-negative bacteria such as enterotoxigenic Escherichia coli (ETEC), where the bacteria secretes a protein, EtpA which binds to the conserved region of the flagellin protein located at the tip of the flagella. The present invention also discloses that EtpA-mediated interaction and intestinal colonization require interaction with flagellin. Also disclosed herein is a vaccine composition that can be used for either active or passive immunization of mammals for the prevention or treatment of infections caused by flagellated Gram-negative bacteria. |
| FILED | Wednesday, March 26, 2008 |
| APPL NO | 12/079304 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/257.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323686 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); C. Shad Thaxton (Chicago, Illinois); David A. Giljohann (Chicago, Illinois); Weston Daniel (Evanston, Illinois) |
| ABSTRACT | Articles, compositions, kits and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids, and an apolipoprotein may be bound to at least the outer surface of the shell. In some embodiments, the structures, when introduced to a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels. |
| FILED | Friday, April 24, 2009 |
| APPL NO | 12/429560 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/450 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323698 | Gu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Frank X. Gu (Waterloo, Canada); Omid C. Farokhzad (Chestnut Hill, Massachusetts); Robert S. Langer (Newton, Massachusetts); Benjamin A. Teply (Omaha, Nebraska) |
| ABSTRACT | The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like. |
| FILED | Wednesday, September 01, 2010 |
| APPL NO | 12/873692 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/489 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323888 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Nanosphere, Inc. (Northbrook, Illinois) |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Robert L. Letsinger (Wilmette, Illinois); Robert C. Mucic (Glendale, California); James J. Storhoff (Evanston, Illinois); Robert Elghanian (Wilmette, Illinois); Thomas A. Taton (Little Canada, Minnesota) |
| ABSTRACT | The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids. |
| FILED | Friday, February 02, 2007 |
| APPL NO | 11/702002 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323890 | Laird et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Peter W. Laird (South Pasadena, California); Cindy A. Carroll (Arcadia, California); Kathleen D. Danenberg (Altadena, California) |
| ABSTRACT | There is disclosed an improved high-throughput and quantitative process for determining methylation patterns in genomic DNA samples based on amplifying modified nucleic acid, and detecting methylated nucleic acid based on amplification-dependent displacement of specifically annealed hybridization probes. Specifically, the inventive process provides for treating genomic DNA samples with sodium bisulfite to create methylation-dependent sequence differences, followed by detection with fluorescence-based quantitative PCR techniques. The process is particularly well suited for the rapid analysis of a large number of nucleic acid samples, such as those from collections of tumor tissues. |
| FILED | Tuesday, June 02, 2009 |
| APPL NO | 12/476981 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323909 | Evans et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Sylvia Evans (Del Mar, California); Ju Chen (San Diego, California); Lizhu Lin (La Jolla, California); Ken Chien (La Jolla, California); Yibing Qyang (San Diego, California); Alessandra Moretti (La Jolla, California); Karl Laugwitz (La Jolla, California) |
| ABSTRACT | The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3β inhibitor. |
| FILED | Thursday, April 29, 2010 |
| APPL NO | 12/770597 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323916 | Harris et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Peter C. Harris (Rochester, Minnesota); Marie C. Hogan (Rochester, Minnesota); Christopher J. Ward (Rochester, Minnesota); Matthew D. Griffin (Galway, Ireland) |
| ABSTRACT | Nucleic acids encoding fibrocystin-L polypeptides and fibrocystin-L polypeptides are provided. Antibodies against the polypeptides, vectors and host cells containing the nucleic acids, methods for using the nucleic acids and polypeptides, and compositions and articles of manufacture also are provided. |
| FILED | Tuesday, June 28, 2011 |
| APPL NO | 13/170458 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.230 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323941 | Shi et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Yang Shi (Brookline, Massachusetts); Yujiang Shi (Boston, Massachusetts) |
| ABSTRACT | LSD1, a homolog of nuclear amine oxidases, functions as a histone demethylase and transcriptional co-repressor. LSD1 specifically demethylates histone H3 lysine 4, which is linked to active transcription. Lysine demethylation occurs via an oxidation reaction that generates formaldehyde. Importantly, RNAi inhibition of LSD1 causes an increase in H3 lysine 4 methylation and concomitant de-repression of target genes, suggesting that LSD1 represses transcription via histone demethylation. The results thus identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histone methylases and demethylases. |
| FILED | Monday, April 05, 2010 |
| APPL NO | 12/754087 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/183 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323961 | Nabel et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); GenVex, Inc. (Gaithersburg, Maryland) |
| INVENTOR(S) | Gary J. Nabel (Washington, District of Columbia); Bimal Chakrabarti (San Diego, California); Wing-Pui Kong (Germantown, Maryland); Yue Huang (Bethesda, Maryland); Zengguang Wang, legal representative (Silver Spring, Maryland); Zhi-Yong Yang (Potomac, Maryland); Jason G. D. Gall (Germantown, Maryland); C. Richter King (New York, New York) |
| ABSTRACT | The invention provides a composition comprising four adenoviral vectors, each comprising a nucleic acid sequence encoding a clade A HIV Env protein, a clade B HIV Env protein, a clade C HIV Env protein, and a clade B HIV Gag-Pol fusion protein, respectively. The invention also provides a method of inducing an immune response against HIV-1 in an animal comprising administering the composition to the animal. |
| FILED | Thursday, April 14, 2011 |
| APPL NO | 13/086884 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/320.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323962 | Dall'Acqua et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | MedImmune, LLC (Gaithersburg, Maryland); Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | William Dall'Acqua (Gaithersburg, Maryland); Leslie S. Johnson (Darnestown, Maryland); Elizabeth Sally Ward (Dallas, Texas) |
| ABSTRACT | The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules. |
| FILED | Wednesday, July 27, 2011 |
| APPL NO | 13/192429 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/320.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323964 | Lee et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The John Hopkins University School of Medicine (Baltimore, Maryland) |
| INVENTOR(S) | Se-Jin Lee (Baltimore, Maryland); Alexandra C. McPherron (Baltimore, Maryland) |
| ABSTRACT | The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can specifically hybridize to such polynucleotides. The present invention also provides an isolated polynucleotide encoding a mature myostatin peptide. |
| FILED | Tuesday, July 01, 2008 |
| APPL NO | 12/166035 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/325 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323969 | Benedict et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Kansas (Lawrence, Kansas) |
| INVENTOR(S) | Stephen H. Benedict (Lawrence, Kansas); Kelli M. Cool (Lawrence, Kansas); Abby L. Dotson (Lawrence, Kansas) |
| ABSTRACT | A method for generating a purified regulatory T cell composition having a CD4+CD25+Foxp3− phenotype from naive T cells having CD4+CD45RA+RO−CD11alo CD27+ phenotype comprising the steps of stimulating a T cell receptor on the naive T cells and stimulating ICAM-1 on the naive T cells. |
| FILED | Friday, May 16, 2008 |
| APPL NO | 12/122377 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/372.300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323970 | Glimcher |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Laurie H. Glimcher (West Newton, Massachusetts) |
| ABSTRACT | The instant invention is based, at least in part, on the discovery that T-bet controls ThI cell recruitment to sites of inflammation. This invention pertains to, inter alia, methods of identifying agents that modulate the effects of T-bet on the recruitment of T cells to sites of inflammation by modulating P-selectin-mediated T cell rolling and/or stable adherence of a T cell to a vascular endothelial cell, as well as methods of use therefore. |
| FILED | Wednesday, May 31, 2006 |
| APPL NO | 11/920868 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/375 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323977 | Abramson et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | State of Oregon acting by and through the State Board of Higher Education on behalf of Portland State University (Portland, Oregon) |
| INVENTOR(S) | Jonathan J. Abramson (Beaverton, Oregon); Benjamin S. Marinov (Portland, Oregon) |
| ABSTRACT | A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the free radical cation and the free radical anion have been formed, the relative redox activity of the subject compound may cause a difference in the rate of photo-bleaching of the mixture and/or the rate of superoxide generation. These differences can be quantified and used to identify the redox activity of the subject compound. This sensitive technique for measuring redox activity can be used to screen compounds for various biological applications. Drugs also can be developed based on the relationship between redox activity and biological activity for particular biological applications. |
| FILED | Tuesday, August 09, 2011 |
| APPL NO | 13/206364 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323987 | Threadgill et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | David Threadgill (Chapel Hill, North Carolina); Daekee Lee (Chapel Hill, North Carolina) |
| ABSTRACT | Provided is a method for screening a plurality of compounds for an ability to bind to a heterodimer of EGFR and another ERBB family member. Also provided are compounds that bind to heterodimers of EGFR and another ERBB family member, and methods of using the identified compounds to suppress the growth of a tumor associated with EGFR heterodimer activity in a subject. |
| FILED | Thursday, February 17, 2005 |
| APPL NO | 10/584960 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/538 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324148 | Hawiger et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Jack J. Hawiger (Nashville, Tennessee); Daniel Robinson (Lexington, Kentucky); Ruth Ann Veach (Brentwood, Tennessee); Xue Yan Liu (Nashville, Tennessee); Danya Liu (Nashville, Tennessee); Sheila Downs (Nashville, Tennessee); Robert D. Collins (Nashville, Tennessee); Yao-Zhong Lin (Nashville, Tennessee) |
| ABSTRACT | The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized for purposes such as peptide therapy, gene transfer, and antisense therapy to regulate and/or eradicate systemic inflammatory response syndromes such as endotoxic shock. |
| FILED | Friday, December 13, 2002 |
| APPL NO | 10/319316 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/1.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324151 | Wang |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Feinstein Institute for Medical Research (Manhasset, New York) |
| INVENTOR(S) | Ping Wang (Roslyn, New York) |
| ABSTRACT | Methods are disclosed for treating sepsis and septic shock using a combination of ghrelin and growth hormone, and for using ghrelin to reduce organ and tissue injury and improve survival after combined radiation exposure and sepsis. |
| FILED | Friday, November 14, 2008 |
| APPL NO | 12/291908 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/1.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324158 | McCarty et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Neal McCarty (Atlanta, Georgia); Christopher H. Thompson (Atlanta, Georgia); Julia Kubanek (Decatur, Georgia) |
| ABSTRACT | Compositions and methods of using scorpion venom peptide that is a ligand for ClC channels are provided. One aspect provides a pharmaceutical composition containing an amount of GaTx2 effective to inhibit ClC activity. Methods of treating a disorder or symptom of a disorder related to aberrant ClC channel activity are also provided. |
| FILED | Thursday, July 12, 2007 |
| APPL NO | 12/373556 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/7.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324169 | Quinn |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Timothy P. Quinn (San Francisco, California) |
| ABSTRACT | The present invention provides fusion proteins comprising an extracellular domain of a VEGF receptor and a death ligand. The fusion proteins bind to VEGF and to death receptors on tumor cells thereby inhibiting VEGF activation of VEGF receptors and inducing apoptosis in the tumor cells. Fusion proteins of the present invention are useful for inducing apoptosis and cytotoxic effects in cells, treating cancer and diseases or disorders related to unregulated angiogenesis and/or vasculogenesis. Thus, this invention further provides methods for treating angiogenesis related diseases using the fusion proteins, polynucleotides encoding the fusion proteins, vectors containing the polynucleotides, pharmaceutical compositions and kits containing the fusion proteins or the polynucleotides encoding the fusion proteins. |
| FILED | Tuesday, August 15, 2006 |
| APPL NO | 12/063897 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/18.900 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324170 | Matsuyama |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Case Western Reserve University (Cleveland, Ohio) |
| INVENTOR(S) | Shigemi Matsuyama (Beachwood, Ohio) |
| ABSTRACT | A method of inhibiting apoptosis in a cell includes administering to a cell an effective amount of a cell penetrating peptide (CPP), wherein the CPP consists of about 5 to about 41 amino acids and is substantially homologous to a portion of the C-terminal region of IFNγR2. |
| FILED | Monday, August 09, 2010 |
| APPL NO | 12/853122 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/18.900 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324172 | Kuliopulos et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Tufts Medical Center, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Athan Kuliopulos (Winchester, Massachusetts); Lidija Covic (Somerville, Massachusetts) |
| ABSTRACT | The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same. |
| FILED | Tuesday, November 28, 2006 |
| APPL NO | 11/606368 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/20.600 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324178 | Simpson, Jr. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Paul C. Simpson, Jr. (San Francisco, California) |
| ABSTRACT | Methods for treating or preventing cardiomyopathy in a subject by administering an α1 adrenergic receptor agonist, wherein the treatment does not result in increased blood pressure are provided. |
| FILED | Monday, November 02, 2009 |
| APPL NO | 12/610720 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/34 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324181 | Corey et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | David R. Corey (Dallas, Texas); David S. Shames (Dallas, Texas); Bethany A. Janowski (Dallas, Texas); John D. Minna (Dallas, Texas) |
| ABSTRACT | Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript. |
| FILED | Tuesday, March 30, 2010 |
| APPL NO | 12/750201 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/44 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324182 | Kumar-Singh et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Tufts University (Boston, Massachusetts) |
| INVENTOR(S) | Rajendra Kumar-Singh (Boston, Massachusetts); Siobhan M Cashman (Boston, Massachusetts); Kasmir Ramo (Cambridge, Massachusetts) |
| ABSTRACT | Methods and compositions for treating a subject having age-related macular degeneration (AMD), methods of assaying human macular degeneration (MD), and methods and kits for assaying potential therapeutic agents for treatment of human MD are provided herein. |
| FILED | Friday, February 13, 2009 |
| APPL NO | 12/867566 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/44.R00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324184 | Prestwich et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| INVENTOR(S) | Glenn D. Prestwich (Salt Lake City, Utah); Kelly R. Kirker (Bozeman, Montana); Steven D. Gray (Salt Lake City, Utah); Janice Gray, legal representative (Salt Lake City, Utah); Xiao Zheng Shu (Dublin, California); Hao Li (San Diego, California); Yanchun Liu (Nashville, Tennessee) |
| ABSTRACT | Described herein are composites that inhibit or reduce adhesion between two or more tissues. Also described herein are methods of using the composites. |
| FILED | Thursday, May 13, 2004 |
| APPL NO | 10/556693 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/54 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324237 | Smith et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles D. Smith (Isle of Palms, South Carolina); Kevin J. French (Harrisburg, Pennsylvania); Lynn W. Maines (Hummelstown, Pennsylvania) |
| ABSTRACT | The invention includes processes mainly for the treatment of a inflammatory diseases, such as inflammatory bowel disease, arthritis, atherosclerosis, asthma, allergy, inflammatory kidney disease, circulatory shock, multiple sclerosis, chronic obstructive pulmonary disease, skin inflammation, periodontal disease, psoriasis and T cell-mediated diseases of immunity, including allergic encephalomyelitis, allergic neuritis, transplant allograft rejection, graft versus host disease, myocarditis, thyroiditis, nephritis, systemic lupus erthematosus, and insulin-dependent diabetes mellitus. The processes involve treating a patient with a pharmaceutical composition containing an active ingredient that inhibits the activity of sphingosine kinase. |
| FILED | Friday, May 19, 2006 |
| APPL NO | 11/437988 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/285 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324258 | Glick et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Gary D. Glick (Ann Arbor, Michigan); Gina Ney (Ann Arbor, Michigan) |
| ABSTRACT | The present invention relates to a family of guanidine-based F1F0-ATPase inhibitors, e.g., mitochondrial F1F0-ATPase inhibitors, methods for their discovery, and their use as therapeutic agents for treating certain disorders. |
| FILED | Thursday, September 11, 2008 |
| APPL NO | 12/677598 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/383 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324262 | Yuan et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Junying Yuan (Waban, Massachusetts); Alexei Degterev (Brookline, Massachusetts); Junichi Hitomi (Brookline, Massachusetts); Gregory D. Cuny (Somerville, Massachusetts); Prakash Jagtap (North Andover, Massachusetts) |
| ABSTRACT | The present invention features compounds, pharmaceutical compositions, and methods for treating trauma, ischemia, stroke, degenerative diseases associated with cellular necrosis, and other conditions. Screening assays for identifying compounds useful for treating these conditions are also described. |
| FILED | Wednesday, December 20, 2006 |
| APPL NO | 12/086792 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/403 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324270 | Maeda et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Tadao Maeda (Mayfield Heights, Ohio); David Saperstein (Seattle, Washington); Krzysztof Palczewski (Bay Village, Ohio) |
| ABSTRACT | A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids. |
| FILED | Tuesday, February 10, 2009 |
| APPL NO | 12/368427 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/529 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324277 | Freeman |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Bruce A. Freeman (Pittsburgh, Pennsylvania) |
| ABSTRACT | Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-γ. |
| FILED | Friday, August 01, 2008 |
| APPL NO | 12/670951 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/560 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324282 | Gerson et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Case Western Reserve University (Cleveland, Ohio) |
| INVENTOR(S) | Stanton L. Gerson (Hunting Valley, Ohio); Lili Liu (Northfield, Ohio) |
| ABSTRACT | This application provides compositions and methods useful in the treatment of certain cancers. In part, this application is based on the recognition that certain molecules that target abasic lesions or AP sites in DNA improve, augment, or potentiate the chemotherapeutic efficacy of certain anticancer agents. |
| FILED | Wednesday, February 19, 2003 |
| APPL NO | 10/505400 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/645 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324284 | Danishefsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sloan-Kettering Institute for Cancer Research (New York, New York) |
| INVENTOR(S) | Samuel J. Danishefsky (Englewood, New Jersey); Christoph Gaul (Liestal, Switzerland); Jon T. Njardarson (Ithaca, New York) |
| ABSTRACT | The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis, wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein. |
| FILED | Thursday, May 12, 2011 |
| APPL NO | 13/106625 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/690 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324333 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Xianghui Liu (Waukegan, Illinois); Jingtao Zhang (Lansdale, Pennsylvania); David M. Lynn (Middleton, Wisconsin) |
| ABSTRACT | Materials and methods for the generation of polyelectrolyte multilayers that can erode to release cationic components. The multilayers comprise layers that contain one or more cations and one or more charge-dynamic anionic polymers. Charge-dynamic anionic polymers contain side chains having removable functional groups. Removal of the functional groups results in a change in the net change in the charge of the polymer which can disrupt interactions between cations and the anionic polymers and facilitate release of cations. |
| FILED | Friday, June 05, 2009 |
| APPL NO | 12/479582 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Synthetic resins or natural rubbers 526/304 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324344 | Kisiel |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | STC.UNM (Albuquerque, New Mexico) |
| INVENTOR(S) | Walter Kisiel (Albuquerque, New Mexico) |
| ABSTRACT | Isolated polypeptides, nucleic acids, and methods relating to cellular internalization of materials are described herein. Generally, the isolated polypeptides include a membrane transduction domain of human tissue factor pathway inhibitor-2 (TFPI-2). In some cases, the isolated polypeptide can be a fusion peptide that includes a membrane transduction domain of human TFPI-2 and a heterologous peptide domain. The nucleic acids include nucleic acids that encode the isolated polypeptides described herein. The methods generally include providing a composition that includes a membrane transduction domain of human TFPI-2 coupled to a material, and contacting the composition with a cell under conditions effective to permit the cell to internalize the composition. |
| FILED | Wednesday, October 07, 2009 |
| APPL NO | 13/129942 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/326 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324347 | Mirzaei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Institute for Systems Biology (Seattle, Washington) |
| INVENTOR(S) | Hamid Mirzaei (Seattle, Washington); Rudolf Aebersold (Zurich, Switzerland) |
| ABSTRACT | Methods of using halogenated peptides as internal standards for liquid chromatography-mass spectrometry, and novel halogenated peptides useful for the same, are disclosed. In particular, methods of using halogenated peptides as internal standards in proteomic analyses, as well as methods of using halogenated peptides to conduct quality control assessments of and/or to calibrate liquid chromatography-mass spectrometry systems are disclosed. |
| FILED | Wednesday, February 17, 2010 |
| APPL NO | 12/707137 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/330 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324353 | Jensen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | City of Hope (Durate, California) |
| INVENTOR(S) | Michael Jensen (Sierra Madre, California) |
| ABSTRACT | The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy. In a preferred embodiment is a glioma-specific immunoreceptor comprising the extracellular targeting domain of the IL-13Rα2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain. |
| FILED | Friday, March 11, 2011 |
| APPL NO | 13/046518 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/387.300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324369 | Chen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Si-Yi Chen (Pasadena, California) |
| ABSTRACT | The present invention provides adjuvants, vaccines and therapies in which antigen presentation is enhanced through inhibition of negative immune regulators. The compositions and methods are useful for generating immune responses against antigens, including microbial pathogens and tumor-associated antigens, by way of inhibiting a negative immune regulator in a cell and providing a proinflammatory stimulus. In particular, nucleotides encoding inhibitors of negative immune regulators, antigens, and co-stimulatory molecules are contacted with immune cells in order to elicit a therapeutic or prophylactic response. |
| FILED | Wednesday, November 26, 2008 |
| APPL NO | 12/744651 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/24.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324376 | Binder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Joseph Bartholomew Binder (Berkeley, California); Ronald Thaddeus Raines (Madison, Wisconsin) |
| ABSTRACT | A method for converting a carbohydrate to a furan in a polar aprotic solvent in the presence of a chloride, bromide, or iodide salt or a mixture thereof and optionally in the presence of an acid catalyst, a metal halide catalyst and/or an ionic liquid (up to 40 wt %). The method can be employed in particular to produce furfural or 5-hydroxymethylfurfural. |
| FILED | Tuesday, June 16, 2009 |
| APPL NO | 12/485755 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Organic compounds 536/124 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324397 | Bergeron, Jr. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| INVENTOR(S) | Raymond J. Bergeron, Jr. (Gainesville, Florida) |
| ABSTRACT | A relatively non-toxic desazadesferrithiocin analog having the formula (I): wherein: R1, R2, R4 and R5 may be the same or different and may be H, straight or branched chain alkyl having up to 14 carbon atoms, e.g., methyl, ethyl, propyl and butyl, or arylalkyl wherein the aryl portion is hydrocarbyl and the alkyl portion is straight or branched chain, the arylalkyl group having up to 14 carbon atoms, R2 optionally being alkoxy having up to 14 carbon atoms; R3 is [(CH2)n—O]x—[(CH2)n—O]y-alkyl; n is, independently, an integer from 1 to 8; x is an integer from 1 to 8; y is an integer from O to 8, and R3O may occupy any position on the phenyl ring except the 4-position, or a salt, hydrate or solvate thereof; and methods and compositions for treating the effects of trivalent metal, i.e., iron, overload. |
| FILED | Friday, March 14, 2008 |
| APPL NO | 12/450194 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Organic compounds 548/201 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324428 | Verdine et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Gregory L. Verdine (Lexington, Massachusetts); Christian E. Schafmeister (Somerville, Massachusetts) |
| ABSTRACT | The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involves (1) synthesizing a peptide from a selected number of natural or non-natural amino acids, wherein said peptide comprises at least two moieties capable of undergoing reaction to promote carbon-carbon bond formation; and (2) contacting said peptide with a reagent to generate at least one crosslinker and to effect stabilization of a secondary structure motif. The present invention, in a preferred embodiment, provides stabilized p53 donor helical peptides. Additionally, the present invention provides methods for disrupting the p53/MDM2 binding interaction comprising (1) providing a crosslinked stabilized α-helical structure; and (2) contacting said crosslinked stabilized α-helical structure with MDM2. |
| FILED | Tuesday, June 08, 2010 |
| APPL NO | 12/796212 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Organic compounds 562/553 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325349 | Cui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Xiquan Cui (Pasadena, California); Lap Man Lee (Arcadia, California); Changhuei Yang (Pasadena, California) |
| ABSTRACT | Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique that may be used employs surface tension at a hydrophobic surface to passively pump the fluid sample through the fluid channel. Another technique uses electrodes to adjust the position of objects in the fluid channel. Another technique computationally adjusts the focal plane of an image wavefront measured using differential interference contrast (DIC) based on Young's interference by back propagating the image wavefront from the detection focal plane to a different focal plane. These techniques can be employed separately or in combination to improve the capabilities of OFM devices. |
| FILED | Tuesday, December 15, 2009 |
| APPL NO | 12/638518 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/515 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326054 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Guang-Hong Chen (Madison, Wisconsin); Jie Tang (Madison, Wisconsin) |
| ABSTRACT | An image reconstruction method for cardiac cone beam CT is provided, in which data acquired as truncated projections using current cardiac flat panel detectors is reconstructed to form a high quality image of a desired cardiac phase. An iterative method is utilized to reconstruct a prior image from all of the acquired truncated data without cardiac gating. Subsequently, a reconstruction method, in which the prior image is utilized in a prior image constrained reconstruction method, is utilized to reconstruct images for each individual cardiac phase. The objective function in such a prior image constrained reconstruction method is modified to incorporate the conditions used in the production of the prior image so that the data truncation problem is properly addressed. |
| FILED | Wednesday, November 25, 2009 |
| APPL NO | 12/626366 |
| ART UNIT | 2882 — Optics |
| CURRENT CPC | Image analysis 382/232 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326427 | Pasricha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Pankaj Pasricha (Cupertino, California); Jlande Chen (Houston, Texas) |
| ABSTRACT | A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors. |
| FILED | Wednesday, July 14, 2010 |
| APPL NO | 12/836377 |
| ART UNIT | 3762 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery: Light, thermal, and electrical application 67/40 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 08322199 | Reed |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Administrators of the Tulane Educational Fund (New Orleans, Louisiana) |
| INVENTOR(S) | Wayne F. Reed (New Orleans, Louisiana) |
| ABSTRACT | The present invention provides an automatic sampling and dilution apparatus for use in a polymer analysis system. The apparatus comprises (a) a primary mixing chamber; (b) a primary pump capable of continuously withdrawing a variable viscosity liquid from a reactor at a selectable, fixed withdrawal rate over a varying viscosity range of about 50 to about 5,000,000 centipoise (cP) for continuously conveying the variable viscosity polymer-containing liquid into the primary mixing chamber; (c) a first dilution pump for continuously delivering a first dilution solvent into the primary mixing chamber at a selectable, fixed flow rate to mix with the variable viscosity liquid in the mixing chamber and thereby form a diluted polymer-containing liquid therein; and (d) a secondary pump for continuously conveying the diluted polymer-containing liquid into a flow-through detector. A polymer analysis system utilizing the automatic sampling and dilution apparatus is also provided. |
| FILED | Wednesday, February 14, 2007 |
| APPL NO | 11/706458 |
| ART UNIT | 1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Measuring and testing 073/64.560 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322213 | Trusov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Alexander A. Trusov (Irvine, California); Adam R. Schofield (Irvine, California); Andrei M. Shkel (Irvineq, California) |
| ABSTRACT | A vibratory rate z-axis gyroscope is characterized by drive-mode and sense-mode quality factors and rate sensitivity and is fabricated with at least two decoupled vibratory tines, a levered drive-mode mechanism coupled between the tines to structurally force anti-phase drive-mode motion of the tines at a predetermined drive frequency, to eliminate spurious frequency modes of the anti-phase drive-mode motion of the tines lower than the predetermined drive frequency and to provide synchronization of drive- and sense-mode motion of the tines, and a sense-mode mechanism coupled between the tines arranged and configured to provide a linearly coupled, dynamically balanced anti-phase sense-mode motion of the tines to minimize substrate energy dissipation and to enhance the sense-mode quality factor and rate sensitivity. |
| FILED | Tuesday, June 08, 2010 |
| APPL NO | 12/796452 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/504.120 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322534 | Farha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Omar K. Farha (Morton Grove, Illinois); Joseph T. Hupp (Northfield, Illinois) |
| ABSTRACT | A method of purification of a solid mixture of a metal-organic framework (MOF) material and an unwanted second material by disposing the solid mixture in a liquid separation medium having a density that lies between those of the wanted MOF material and the unwanted material, whereby the solid mixture separates by density differences into a fraction of wanted MOF material and another fraction of unwanted material. |
| FILED | Tuesday, March 23, 2010 |
| APPL NO | 12/661771 |
| ART UNIT | 1776 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Classifying, separating, and assorting solids 29/172 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323011 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daniel C. H. Yang (Santa Monica, California); Shih-Hsi Tong (San Gabriel, California) |
| ABSTRACT | A method of manufacturing a rotor to be used in a dual-rotor lobe pump system for pumping a material at a periodic rate is provided. The method includes selecting a desired periodic flow rate for the material, selecting a number of lobes for the rotor, and selecting either a thickness of the rotor or a spacing between the dual-rotors' axes of rotation in the lobe pump. The method also includes determining the profile for the rotor based on the desired periodic flow rate, so that when the rotor is operated within the dual-rotor lobe pump system, the material can be pumped at substantially the desired periodic flow rate. In another embodiment of the invention, a lobe pump rotor profile is formed by the method described above. |
| FILED | Tuesday, March 10, 2009 |
| APPL NO | 12/401605 |
| ART UNIT | 3748 — Printing/Measuring and Testing |
| CURRENT CPC | Rotary expansible chamber devices 418/150 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323273 | Rylander et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Christopher G. Rylander (Blacksburg, Virginia); Thomas E. Milner (Austin, Texas); Oliver Stumpp (Palo Alto, California); J. Stuart Nelson (Laguna Niguel, California) |
| ABSTRACT | Embodiments of the present disclosure provides systems, devices, and methods for non-invasively modifying, maintaining, or controlling local tissue optical properties. Methods and devices of the disclosure may be used for optically clearing tissue, for example, for diagnostic and/or therapeutic purposes. A method of optically clearing a tissue may comprise contacting the tissue with an optical clearing device having a base, an array of pins fixed to one side of the base, a brim fixed to the base, an inlet port in the base, an exit port in the base, and a handpiece interface tab fixed to the side of the base opposite the array of pins, applying a mechanical force to the tissue, and illuminating said tissue with at least one wavelength of light through the optical clearing device. A method may further comprise controlling the temperature of the tissue illuminated. |
| FILED | Saturday, August 12, 2006 |
| APPL NO | 11/502687 |
| ART UNIT | 3769 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery 66/9 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323488 | Tai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); City of Hope (Duarte, California) |
| INVENTOR(S) | Yu-Chong Tai (Pasadena, California); Qing He (Rancho Palos Verdes, California); Jun Xie (Niskayuna, New York); Changlin Pang (Pasadena, California); Terry D. Lee (San Dimas, California); Damien Rodger (South Pasadena, California); Matthieu Liger (San Francisco, California) |
| ABSTRACT | Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC. |
| FILED | Monday, February 28, 2011 |
| APPL NO | 13/037192 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Liquid purification or separation 210/198.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323637 | Swiston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Albert J. Swiston (Baltimore, Maryland); Michael F. Rubner (Westford, Massachusetts); Robert E. Cohen (Jamaica Plain, Massachusetts); Darrell J. Irvine (Arlington, Massachusetts) |
| ABSTRACT | Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs). |
| FILED | Thursday, April 09, 2009 |
| APPL NO | 12/421162 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323744 | Connor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Steve T. Connor (Stanford, California); Jung-Yong Lee (Menlo Park, California); Yi Cui (Sunnyvale, California); Peter Peumans (Sunnyvale, California) |
| ABSTRACT | A variety of methods, devices, systems and arrangements are implemented involving nanowire meshes. One such method is implemented to include synthesizing metal nanowires in a solution containing a structure-directing agent. The metal nanowires are deposited on a substrate to form a sheet of nanowires. The deposited metal nanowires are heated to a temperature less than about 200 degrees Celsius and for a period of time of about 10 minutes to 60 minutes, thereby removing the structure-directing agent and modifying the electrical conductivity and optical transmittance of the sheet of nanowires. |
| FILED | Friday, January 09, 2009 |
| APPL NO | 12/351313 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Coating processes 427/383.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323784 | Green et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Northwestern Universtiy (Evanston, Illinois) |
| INVENTOR(S) | Alexander A. Green (Evanston, Illinois); Mark C. Hersam (Evanston, Illinois) |
| ABSTRACT | Various methods related to the preparation of transparent electrical conductors based on carbon nanotubes having enhanced optical and electrical properties are disclosed. In some embodiments, the methods involve employing carbon nanotubes that have been presorted according to electronic type and/or optical absorbance for use in transparent electrical conductors. Other embodiments involve use of carbon nanotube bundles that have been pre-sorted according to bundle density. |
| FILED | Monday, August 25, 2008 |
| APPL NO | 12/229595 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Stock material or miscellaneous articles 428/220 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323956 | Reardon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| INVENTOR(S) | Kenneth F. Reardon (Fort Collins, Colorado); Lawrence Philip Wackett (St. Paul, Minnesota) |
| ABSTRACT | Enzymatic biosensors and methods of producing distal tips for biosensor transducers for use in detecting one or more analytes selected from organic compounds susceptible to dehalogenation, organic compounds susceptible to oxygenation, organic compounds susceptible to deamination, organosulfate compounds susceptible to hydrolysis, and organophosphate compounds susceptible to hydrolysis are disclosed herein, as well as biosensor arrays, methods of detecting and quantifying analytes within a mixture, and devices and methods for delivering reagents to enzymes disposed within the distal tip of a biosensor. |
| FILED | Thursday, January 22, 2009 |
| APPL NO | 12/358140 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/287.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324087 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Chongwu Zhou (Arcadia, California); Lewis Gomez De Arco (Los Angeles, California); Akshay Kumar (Los Angeles, California) |
| ABSTRACT | Among others, techniques are described for forming nanotubes. In one aspect, a method includes forming a base layer of a transition metal on a substrate. The method also includes heating the substrate with the base layer in a mixture of gases to grow nanotubes on the base layer. |
| FILED | Friday, March 19, 2010 |
| APPL NO | 12/728179 |
| ART UNIT | 2894 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/509 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324158 | McCarty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Neal McCarty (Atlanta, Georgia); Christopher H. Thompson (Atlanta, Georgia); Julia Kubanek (Decatur, Georgia) |
| ABSTRACT | Compositions and methods of using scorpion venom peptide that is a ligand for ClC channels are provided. One aspect provides a pharmaceutical composition containing an amount of GaTx2 effective to inhibit ClC activity. Methods of treating a disorder or symptom of a disorder related to aberrant ClC channel activity are also provided. |
| FILED | Thursday, July 12, 2007 |
| APPL NO | 12/373556 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/7.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324197 | Farrell |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Virginia Commonwealth University (Richmond, Virginia) |
| INVENTOR(S) | Nicholas P. Farrell (Richmond, Virginia) |
| ABSTRACT | Trans-platinum compounds comprising carboxylato groups are disclosed, with anti-cancer usefulness. The carboxylato groups participate in solubilizing trans-platinum compounds to which they are attached. |
| FILED | Friday, August 11, 2006 |
| APPL NO | 11/502621 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/184 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324357 | Chelyapov |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Nicolas Chelyapov (Los Angeles, California) |
| ABSTRACT | A universal detection system based on allosteric aptamers, signal amplification cascade, and eye-detectable phrase transition. A broadly applicable homogeneous detection system is provided. It utilizes components of the blood coagulation cascade in the presence of polystyrene microspheres (MS) as a signal amplifier. Russell's viper venom factor X activator (RVV-X) triggers the cascade, which results in an eye-visible phase transition—precipitation of MS bound to clotted fibrin. An allosteric RNA aptamer, RNA132, with affinity for RVV-X and human vascular endothelial growth factor (VEGF165) was created. RNA132 inhibits enzymatic activity of RVV-X. The effector molecule, VEGF165, reverses the inhibitory activity of RNA132 on RVV-X and restores its enzymatic activity, thus triggering the cascade and enabling the phase transition. Similar results were obtained for another allosteric aptamer modulated by a protein tyrosine phosphatase. The assay is instrumentation-free for both processing and readout. |
| FILED | Tuesday, March 06, 2007 |
| APPL NO | 11/682796 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/23.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324604 | Pagilla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Regents for Oklahoma State University (Stillwater, Oklahoma) |
| INVENTOR(S) | Prabhakar R. Pagilla (Stillwater, Oklahoma); Aravind Seshadri (Stillwater, Oklahoma) |
| ABSTRACT | A web edge sensor is disclosed. The web edge sensor has a light source directing light incident to an edge of a web. The edge of the web scatters the light and a sensor array that detects a first portion of the light scattered from the edge of the web and rejects a second portion to determine a position of the web edge. |
| FILED | Thursday, November 08, 2007 |
| APPL NO | 11/937125 |
| ART UNIT | 2878 — Optics |
| CURRENT CPC | Radiant energy 250/559.360 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324937 | Verbauwhede et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ingrid Verbauwhede (Santa Monica, California); Kris J. V. Tiri (Genk, Belgium) |
| ABSTRACT | Methods for differential pair conductor routing in a logic circuit. One embodiment includes a method for differential pair conductor routing in a logic circuit, by routing conductors of a first line width to obtain a first routing for a first logic library, wherein vertical and horizontal paths are separated such that vertical and horizontal conductors do not short, wherein connections between the vertical and horizontal paths are provided by vias, separating conductor paths in the first routing into differential paths by splitting the conductors of a first line width into spaced parallel conductors of a second line width, where the second line width is smaller than the first line width, separating the vias into pairs of vias, and replacing the first logic library with a differential logic library. |
| FILED | Thursday, March 17, 2011 |
| APPL NO | 13/050317 |
| ART UNIT | 2819 — Semiconductors/Memory |
| CURRENT CPC | Electronic digital logic circuitry 326/101 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325774 | Botez et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Dan Botez (Madison, Wisconsin); Jae Cheol Shin (Madison, Wisconsin) |
| ABSTRACT | Semiconductor structures and laser devices including the semiconductor structures are provided. The semiconductor structures have a quantum cascade laser (QCL) structure including an electron injector, an active region, and an electron extractor. The active region of the semiconductor structures includes a configuration of quantum wells and barriers that virtually suppresses electron leakage, thereby providing laser devices including such structures with superior electro-optical characteristics. |
| FILED | Thursday, August 12, 2010 |
| APPL NO | 12/855476 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Coherent light generators 372/45.10 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326451 | Schantz et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Q-Track Corporation (Huntsville, Alabama) |
| INVENTOR(S) | Hans Gregory Schantz (Huntsville, Alabama); Peter J. Beucher (Owens Cross Roads, Alabama) |
| ABSTRACT | An inventory control system and method uses a locating device associated with a mover and identifies an ID tagged asset using an ID reader also associated with the mover. Thus, a single relatively high-cost locating device may be temporarily associated with the asset, enabling precise location of a multitude of assets as a mover traverses an inventory area. The asset location and identification may be associated in a database. The asset location may be refined by using additional measurement devices, for example a forklift height sensor, to determine extension from a locating device. A further embodiment utilizes RFID or barcode technology for the ID tag. The locating device may utilize near-field location technology, signals-of-opportunity, or other RTLS technologies. |
| FILED | Monday, June 06, 2011 |
| APPL NO | 13/153640 |
| ART UNIT | 3651 — Material and Article Handling |
| CURRENT CPC | Data processing: Generic control systems or specific applications 7/215 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08327182 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Board of Governors for Higher Education, The State of Rhode Island and Providence Plantations (Providence, Rhode Island) |
| INVENTOR(S) | Qing Yang (Saunderstown, Rhode Island); Weijun Xiao (Kingston, Rhode Island) |
| ABSTRACT | A method is disclosed for recovering data associated with a damaged file stored in a NAND gate array memory. The method includes the steps of: identifying all meta data associated with the damaged file; identifying each logical block address of all identified meta data; collecting all physical block addresses associated with one of the identified logical block addresses or the identified meta data; counting in a replace table (ReplTable) a number of matches to a physical block address of the damaged file for each physical block address of the damaged file; choosing a block in a linked list that corresponds to the physical block address of the block in the linked list; and linking all chosen blocks to form a replicated file. |
| FILED | Friday, October 22, 2010 |
| APPL NO | 12/910132 |
| ART UNIT | 2113 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Error detection/correction and fault detection/recovery 714/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08327327 | Bierhoff et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Kevin M. Bierhoff (Pittsburgh, Pennsylvania); Jonathan Aldrich (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method for statically checking an object-oriented computer program module includes the step of identifying objects within a computer program module, at least one of the objects having a plurality of references thereto, possibly from multiple clients. A discipline of permissions is imposed on the objects identified within the computer program module. The permissions enable tracking, from among a discrete set of changeable states, a subset of states each object might be in. A determination is made regarding whether the imposed permissions are violated by a potential reference to any of the identified objects. The results of the determination are output to a user. |
| FILED | Friday, March 21, 2008 |
| APPL NO | 12/077830 |
| ART UNIT | 2191 — Interprocess Communication and Software Development |
| CURRENT CPC | Data processing: Software development, installation, and management 717/116 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 08322143 | Uhm et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | General Electric Company (Schenectady, New York) |
| INVENTOR(S) | Jong Ho Uhm (Simpsonville, South Carolina); Thomas Edward Johnson (Greer, South Carolina) |
| ABSTRACT | According to various embodiments, a system includes a staggered multi-nozzle assembly. The staggered multi-nozzle assembly includes a first fuel nozzle having a first axis and a first flow path extending to a first downstream end portion, wherein the first fuel nozzle has a first non-circular perimeter at the first downstream end portion. The staggered multi-nozzle assembly also includes a second fuel nozzle having a second axis and a second flow path extending to a second downstream end portion, wherein the first and second downstream end portions are axially offset from one another relative to the first and second axes. The staggered multi-nozzle assembly further includes a cap member disposed circumferentially about at least the first and second fuel nozzles to assemble the staggered multi-nozzle assembly. |
| FILED | Tuesday, January 18, 2011 |
| APPL NO | 13/008890 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Power plants 060/737 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322300 | Pavani et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | SunPower Corporation (San Jose, California) |
| INVENTOR(S) | Luca Pavani (Gilroy, California); Emmanuel Abas (Sta. Rosa, Philippines) |
| ABSTRACT | A non-contact edge coating apparatus includes an applicator for applying a coating material on an edge of a solar cell substrate and a control system configured to drive the applicator. The control system may drive the applicator along an axis to maintain a distance with an edge of the substrate as the substrate is rotated to have the edge coated with a coating material. The applicator may include a recessed portion into which the edge of the substrate is received for edge coating. For example, the applicator may be a roller with a groove. Coating material may be introduced into the groove for application onto the edge of the substrate. A variety of coating materials may be employed with the apparatus including hot melt ink and UV curable plating resist. |
| FILED | Thursday, February 07, 2008 |
| APPL NO | 12/069043 |
| ART UNIT | 1717 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Coating apparatus 118/321 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322328 | Solberg |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Jerome Michael Solberg (Berkeley, California) |
| ABSTRACT | An improved railgun, railgun barrel, railgun projectile, and railgun system for accelerating a solid-to-hybrid transitioning armature projectile using a barrel having a bore that does not conform to a cross-sectional profile of the projectile, to contact and guide the projectile only by the rails in a low pressure bore volume so as to minimize damage, failure, and/or underperformance caused by plasma armatures, insulator ablation, and/or restrikes. |
| FILED | Wednesday, May 18, 2011 |
| APPL NO | 13/110851 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Mechanical guns and projectors 124/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322534 | Farha et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Omar K. Farha (Morton Grove, Illinois); Joseph T. Hupp (Northfield, Illinois) |
| ABSTRACT | A method of purification of a solid mixture of a metal-organic framework (MOF) material and an unwanted second material by disposing the solid mixture in a liquid separation medium having a density that lies between those of the wanted MOF material and the unwanted material, whereby the solid mixture separates by density differences into a fraction of wanted MOF material and another fraction of unwanted material. |
| FILED | Tuesday, March 23, 2010 |
| APPL NO | 12/661771 |
| ART UNIT | 1776 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Classifying, separating, and assorting solids 29/172 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323463 | Christie et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Praxair Technology, Inc. (Danbury, Connecticut) |
| INVENTOR(S) | Gervase Maxwell Christie (Williamsville, New York); Jamie Robyn Wilson (Arlington, Massachusetts); Bart Antonie van Hassel (Weatgue, Connecticut) |
| ABSTRACT | A composite oxygen transport membrane having a dense layer, a porous support layer and an intermediate porous layer located between the dense layer and the porous support layer. Both the dense layer and the intermediate porous layer are formed from an ionic conductive material to conduct oxygen ions and an electrically conductive material to conduct electrons. The porous support layer has a high permeability, high porosity, and a high average pore diameter and the intermediate porous layer has a lower permeability and lower pore diameter than the porous support layer. Catalyst particles selected to promote oxidation of a combustible substance are located in the intermediate porous layer and in the porous support adjacent to the intermediate porous layer. The catalyst particles can be formed by wicking a solution of catalyst precursors through the porous support toward the intermediate porous layer. |
| FILED | Wednesday, December 15, 2010 |
| APPL NO | 12/968699 |
| ART UNIT | 1759 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemistry: Electrical and wave energy 24/295 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323528 | Jia et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| INVENTOR(S) | Weiyi Jia (Chelmsford, Massachusetts); Xiaojun Wang (Stateboro, Georgia); William Yen (Athens, Georgia); Laurel C. Yen, legal representative (Athens, Georgia); George D. Jia (Lock Haven, Pennsylvania) |
| ABSTRACT | Compositions, methods of making compositions, materials including compositions, crayons including compositions, paint including compositions, ink including compositions, waxes including compositions, polymers including compositions, vesicles including the compositions, methods of making each, and the like are disclosed. |
| FILED | Wednesday, April 02, 2008 |
| APPL NO | 12/080268 |
| ART UNIT | 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Compositions 252/301.4R0 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323614 | Davis et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Thomas A. Davis (El Paso, Texas); Michael A. Matthews (Columbia, South Carolina) |
| ABSTRACT | In accordance with certain embodiments of the present disclosure, a method for hydrolysis of a chemical hydride is provided. The method includes adding a chemical hydride to a reaction chamber and exposing the chemical hydride in the reaction chamber to a temperature of at least about 100° C. in the presence of water and in the absence of an acid or a heterogeneous catalyst, wherein the chemical hydride undergoes hydrolysis to form hydrogen gas and a byproduct material. |
| FILED | Thursday, September 02, 2010 |
| APPL NO | 12/874769 |
| ART UNIT | 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemistry of inorganic compounds 423/648.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323809 | Larson et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | 3M Innovative Properties Company (St. Paul, Minnesota) |
| INVENTOR(S) | James M. Larson (Saint Paul, Minnesota); Phat T. Pham (Little Canada, Minnesota); Matthew H. Frey (Cottage Grove, Minnesota); Steven J. Hamrock (Stillwater, Minnesota); Gregory M. Haugen (Edina, Minnesota); William M. Lamanna (Stillwater, Minnesota) |
| ABSTRACT | The present invention is an electrolyte membrane comprising an acid and a basic polymer, where the acid is a low-volatile acid that is fluorinated and is either oligomeric or non-polymeric, and where the basic polymer is protonated by the acid and is stable to hydrolysis. |
| FILED | Wednesday, September 15, 2010 |
| APPL NO | 12/882310 |
| ART UNIT | 1764 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Chemistry: Electrical current producing apparatus, product, and process 429/33 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323955 | Okandan |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sandia Corporation (Albuquerque, New Mexico) |
| INVENTOR(S) | Murat Okandan (Albuquerque, New Mexico) |
| ABSTRACT | A micromachined patch-clamp apparatus is disclosed for holding one or more cells and providing electrical, chemical, or mechanical stimulation to the cells during analysis with the patch-clamp technique for studying ion channels in cell membranes. The apparatus formed on a silicon substrate utilizes a lower chamber formed from silicon nitride using surface micromachining and an upper chamber formed from a molded polymer material. An opening in a common wall between the chambers is used to trap and hold a cell for analysis using the patch-clamp technique with sensing electrodes on each side of the cell. Some embodiments of the present invention utilize one or more electrostatic actuators formed on the substrate to provide mechanical stimulation to the cell being analyzed, or to provide information about mechanical movement of the cell in response to electrical or chemical stimulation. |
| FILED | Wednesday, March 05, 2003 |
| APPL NO | 10/383163 |
| ART UNIT | 1775 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/285.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324015 | Harley et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | SunPower Corporation (San Jose, California) |
| INVENTOR(S) | Gabriel Harley (Mountain View, California); David Smith (Campbell, California); Peter Cousins (Menlo Park, California) |
| ABSTRACT | The formation of solar cell contacts using a laser is described. A method of fabricating a back-contact solar cell includes forming a poly-crystalline material layer above a single-crystalline substrate. The method also includes forming a dielectric material stack above the poly-crystalline material layer. The method also includes forming, by laser ablation, a plurality of contacts holes in the dielectric material stack, each of the contact holes exposing a portion of the poly-crystalline material layer; and forming conductive contacts in the plurality of contact holes. |
| FILED | Thursday, September 30, 2010 |
| APPL NO | 12/895437 |
| ART UNIT | 2823 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/98 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324323 | Koh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | UOP LLC (Des Plaines, Illinois); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Kyoung Moo Koh (Ann Arbor, Michigan); Antek G. Wong-Foy (Ann Arbor, Michigan); Adam J. Matzger (Ann Arbor, Michigan); Annabelle I. Benin (Schaumburg, Illinois); Richard R. Willis (Cary, Illinois) |
| ABSTRACT | The present invention provides compositions of crystalline coordination copolymers wherein multiple organic molecules are assembled to produce porous framework materials with layered or core-shell structures. These materials are synthesized by sequential growth techniques such as the seed growth technique. In addition, the invention provides a simple procedure for controlling functionality. |
| FILED | Thursday, June 04, 2009 |
| APPL NO | 12/478018 |
| ART UNIT | 1766 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Synthetic resins or natural rubbers 525/389 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324342 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sandia Corporation (Albuquerque, New Mexico) |
| INVENTOR(S) | Zhongchun Wang (Albuquerque, New Mexico); John A. Shelnutt (Tijeras, New Mexico); Craig J. Medforth (Winters, California) |
| ABSTRACT | A porphyrin coordination polymer nanostructure comprising a network of pyridyl porphyrin molecules and coordinating metal ions coordinatively bound through the pyridyl groups. In some embodiments, the porphyrins are metalloporphyrins. A variety of nanostructures are formed by the network polymer, including nanospheres, polygonal nanostructures, nanorods, and nanofibers, depending on a variety of factors including coordination metal ion, porphyrin type, metal of the metalloporphyrin, and degree of agitation during nanostructure formation. Reduction of coordinating metal ions may be used to form metal nanoparticles on the coordination polymer nanostructure. |
| FILED | Wednesday, June 13, 2007 |
| APPL NO | 11/762512 |
| ART UNIT | 1767 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Synthetic resins or natural rubbers 528/395 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324414 | Fox et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Robert V. Fox (Idaho Falls, Idaho); Rene G. Rodriguez (Pocatello, Idaho); Joshua J. Pak (Pocatello, Idaho); Chivin Sun (Pocatello, Idaho); Kelsey R. Margulieux (Pocatello, Idaho); Andrew W. Holland (Pocatello, Idaho) |
| ABSTRACT | Methods of forming single source precursors (SSPs) include forming intermediate products having the empirical formula ½{L2N(μ-X)2M′X2}2, and reacting MER with the intermediate products to form SSPs of the formula L2N(μ-ER)2M′(ER)2, wherein L is a Lewis base, M is a Group IA atom, N is a Group IB atom, M′ is a Group IIIB atom, each E is a Group VIB atom, each X is a Group VIIA atom or a nitrate group, and each R group is an alkyl, aryl, vinyl, (per)fluoro alkyl, (per)fluoro aryl, silane, or carbamato group. Methods of forming polymeric or copolymeric SSPs include reacting at least one of HE1R1E1H and MER with one or more substances having the empirical formula L2N(μ-ER)2M′(ER)2 or L2N(μ-X)2M′(X)2 to form a polymeric or copolymeric SSP. New SSPs and intermediate products are formed by such methods. |
| FILED | Wednesday, December 23, 2009 |
| APPL NO | 12/646474 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Organic compounds 556/14 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324421 | Chavez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | U.S. Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | David E. Chavez (Ranchos de Taos, New Mexico); Darren L. Naud (Los Alamos, New Mexico); Michael A. Hiskey (Colorado Springs, Colorado) |
| ABSTRACT | Preparation of an energetic nitrate ester compound and related intermediates is provided. |
| FILED | Thursday, September 24, 2009 |
| APPL NO | 12/566331 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Organic compounds 558/485 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324651 | Mao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Samuel S. Mao (Castro Valley, California); Gao Liu (Oakland, California); Stephen G. Johnson (Newburyport, Massachusetts) |
| ABSTRACT | A cathode that contain nanostructures that extend into the organic layer of an OLED has been described. The cathode can have an array of nanotubes or a layer of nanoclusters extending out from its surface. In another arrangement, the cathode is patterned and etched to form protruding nanostructures using a standard lithographic process. Various methods for fabricating these structures are provided, all of which are compatible with large-scale manufacturing. OLEDs made with these novel electrodes have greatly enhanced electron injection, have good environmental stability. |
| FILED | Thursday, April 26, 2007 |
| APPL NO | 12/297615 |
| ART UNIT | 2815 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/99 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325633 | Archer et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Charles J. Archer (Rochester, Minnesota); Michael A. Blocksome (Rochester, Minnesota) |
| ABSTRACT | Methods, parallel computers, and computer program products are disclosed for remote direct memory access. Embodiments include transmitting, from an origin DMA engine on an origin compute node to a plurality target DMA engines on target compute nodes, a request to send message, the request to send message specifying a data to be transferred from the origin DMA engine to data storage on each target compute node; receiving, by each target DMA engine on each target compute node, the request to send message; preparing, by each target DMA engine, to store data according to the data storage reference and the data length, including assigning a base storage address for the data storage reference; sending, by one or more of the target DMA engines, an acknowledgment message acknowledging that all the target DMA engines are prepared to receive a data transmission from the origin DMA engine; receiving, by the origin DMA engine, the acknowledgement message from the one or more of the target DMA engines; and transferring, by the origin DMA engine, data to data storage on each of the target compute nodes according to the data storage reference using a single direct put operation. |
| FILED | Thursday, April 26, 2007 |
| APPL NO | 11/740361 |
| ART UNIT | 2463 — Multiplex and VoIP |
| CURRENT CPC | Multiplex communications 370/282 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326477 | Choi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | GM Global Technology Operations LLC (Detroit, Michigan) |
| INVENTOR(S) | Tayoung Choi (Rochester, New York); Dongmei Chen (Austin, Texas) |
| ABSTRACT | A system and method for providing nearly instantaneous power in a fuel cell vehicle. The method includes monitoring the brake pedal angle and the accelerator pedal angle of the vehicle, and if the vehicle driver is pressing both the brake pedal and the accelerator pedal at the same time and the vehicle is in a drive gear, activating a heel and toe mode. When the heel and toe mode is activated, the speed of a cathode compressor is increased to a predetermined speed set-point, which is higher than the normal compressor speed for the pedal position. Thus, when the vehicle brake is removed, the compressor speed is high enough to provide enough air to the cathode, so that the stack can generate nearly immediate power. |
| FILED | Friday, February 26, 2010 |
| APPL NO | 12/713722 |
| ART UNIT | 3661 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Data processing: Vehicles, navigation, and relative location 71/22 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08327077 | Boyle et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Peter A. Boyle (Edinburgh, United Kingdom); Norman H. Christ (Irvington, New York); Alan Gara (Yorktown Heights, New York); Robert D. Mawhinney (New York, New York); Martin Ohmacht (Yorktown Heights, New York); Krishnan Sugavanam (Yorktown Heights, New York) |
| ABSTRACT | A prefetch system improves a performance of a parallel computing system. The parallel computing system includes a plurality of computing nodes. A computing node includes at least one processor and at least one memory device. The prefetch system includes at least one stream prefetch engine and at least one list prefetch engine. The prefetch system operates those engines simultaneously. After the at least one processor issues a command, the prefetch system passes the command to a stream prefetch engine and a list prefetch engine. The prefetch system operates the stream prefetch engine and the list prefetch engine to prefetch data to be needed in subsequent clock cycles in the processor in response to the passed command. |
| FILED | Friday, January 29, 2010 |
| APPL NO | 12/696746 |
| ART UNIT | 2185 — Computer Architecture and I/O |
| CURRENT CPC | Electrical computers and digital processing systems: Memory 711/137 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 08322406 | Du et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | Jian Hua Du (Orlando, Florida); Louis C Chow (Orlando, Florida); Yeong-Ren Lin (Orlando, Florida); Wei Wu (Orlando, Florida); Jayanta Kapat (Oviedo, Florida); William U. Notardonato (Merritt Island, Florida) |
| ABSTRACT | A heat exchanger includes at least one hot fluid flow channel comprising a first plurality of open cell porous elements having first gaps therebetween for flowing a hot fluid in a flow direction and at least one cold fluid flow channel comprising a second plurality of open cell porous elements having second gaps therebetween for flowing a cold fluid in a countercurrent flow direction relative to the flow direction. The thermal conductivity of the porous elements is at least 10 W/m·K. A separation member is interposed between the hot and cold flow channels for isolating flow paths associated these flow channels. The first and second plurality of porous elements at least partially overlap one another to form a plurality of heat transfer pairs which transfer heat from respective ones of the first porous elements to respective ones of the second porous elements through the separation member. |
| FILED | Tuesday, July 14, 2009 |
| APPL NO | 12/502415 |
| ART UNIT | 3784 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Heat exchange 165/166 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322685 | Richard |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | James A. Richard (Grant, Alabama) |
| ABSTRACT | A non-collinear valve actuator includes a primary actuating system and a return spring system with each applying forces to a linkage system in order to regulate the flow of a quarter-turn valve. The primary actuating system and return spring system are positioned non-collinearly, which simply means the primary actuating system and return spring system are not in line with each other. By positioning the primary actuating system and return spring system in this manner, the primary actuating system can undergo a larger stroke while the return spring system experiences significantly less displacement. This allows the length of the return spring to be reduced due to the minimization of displacement thereby reducing the weight of the return spring system. By allowing the primary actuating system to undergo longer strokes, the weight of the primary actuating system may also be reduced. Accordingly, the weight of the non-collinear valve actuator is reduced. |
| FILED | Friday, July 23, 2010 |
| APPL NO | 12/842218 |
| ART UNIT | 3753 — Fluid Handling and Dispensing |
| CURRENT CPC | Valves and valve actuation 251/279 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323182 | Manohara et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harish M. Manohara (Arcadia, California); Anna Liao (Montrose, California); Youngsam Bae (Gardena, California); Hrayr Karnig Shahinian (Beverly Hills, California) |
| ABSTRACT | An endoscope including a rigid section having opposed first and second ends and an opening situated between the first and second ends, the rigid section defining a longitudinal axis; a handle portion coupled to a first end of the rigid section and having first and second scissor-type handles suitable for grasping by a user; and a base part situated at the second end of the rigid section and coupled to the first handle of the scissor-type handles such that displacement of the first handle causes a rotation of the base part. |
| FILED | Thursday, December 18, 2008 |
| APPL NO | 12/338984 |
| ART UNIT | 3779 — Amusement and Education Devices |
| CURRENT CPC | Surgery 6/173 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323246 | Chiravuri et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Srinivas Chiravuri (Ann Arbor, Michigan); Allan Evans (Brighton, Michigan); Yogesh B. Gianchandani (Ann Arbor, Michigan); Jong M. Park (Plymouth, Minnesota) |
| ABSTRACT | A liquid delivery apparatus for the intrathecal delivery of one or more medications to a patient is disclosed. The liquid delivery apparatus generally includes a liquid reservoir, a liquid metering unit fluidly connected to the liquid reservoir, and a catheter delivery tube fluidly connected to the liquid metering unit. Preferably, the liquid delivery apparatus includes two or more liquid reservoirs. In various embodiments, the liquid reservoir includes a deformable balloon and a compressive sleeve spring as a pressure source, the liquid metering unit is a piezoelectrically actuated microvalve, and/or diagnostic sensors are included in the apparatus. The disclosed apparatus are compact, volume-efficient, energy-efficient, capable of delivering accurate fluid volumes, and address problems associated with multi-medication therapies. Methods of operating the liquid delivery apparatus are also disclosed. |
| FILED | Monday, December 08, 2008 |
| APPL NO | 12/810286 |
| ART UNIT | 3763 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery 64/132 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324357 | Chelyapov |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Nicolas Chelyapov (Los Angeles, California) |
| ABSTRACT | A universal detection system based on allosteric aptamers, signal amplification cascade, and eye-detectable phrase transition. A broadly applicable homogeneous detection system is provided. It utilizes components of the blood coagulation cascade in the presence of polystyrene microspheres (MS) as a signal amplifier. Russell's viper venom factor X activator (RVV-X) triggers the cascade, which results in an eye-visible phase transition—precipitation of MS bound to clotted fibrin. An allosteric RNA aptamer, RNA132, with affinity for RVV-X and human vascular endothelial growth factor (VEGF165) was created. RNA132 inhibits enzymatic activity of RVV-X. The effector molecule, VEGF165, reverses the inhibitory activity of RNA132 on RVV-X and restores its enzymatic activity, thus triggering the cascade and enabling the phase transition. Similar results were obtained for another allosteric aptamer modulated by a protein tyrosine phosphatase. The assay is instrumentation-free for both processing and readout. |
| FILED | Tuesday, March 06, 2007 |
| APPL NO | 11/682796 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/23.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08327327 | Bierhoff et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Kevin M. Bierhoff (Pittsburgh, Pennsylvania); Jonathan Aldrich (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method for statically checking an object-oriented computer program module includes the step of identifying objects within a computer program module, at least one of the objects having a plurality of references thereto, possibly from multiple clients. A discipline of permissions is imposed on the objects identified within the computer program module. The permissions enable tracking, from among a discrete set of changeable states, a subset of states each object might be in. A determination is made regarding whether the imposed permissions are violated by a potential reference to any of the identified objects. The results of the determination are output to a user. |
| FILED | Friday, March 21, 2008 |
| APPL NO | 12/077830 |
| ART UNIT | 2191 — Interprocess Communication and Software Development |
| CURRENT CPC | Data processing: Software development, installation, and management 717/116 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 08323406 | Bondokov et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Crystal IS, Inc. (Green Island, New York) |
| INVENTOR(S) | Robert T. Bondokov (Watervliet, New York); Kenneth E. Morgan (Castleton, New York); Leo J. Schowalter (Latham, New York); Glen A. Slack (Scotia, New York) |
| ABSTRACT | Bulk single crystal of aluminum nitride (AlN) having an a real planar defect density≦100 cm−2. Methods for growing single crystal aluminum nitride include melting an aluminum foil to uniformly wet a foundation with a layer of aluminum, the foundation forming a portion of an AlN seed holder, for an AlN seed to be used for the AlN growth. The holder may consist essentially of a substantially impervious backing plate. |
| FILED | Thursday, January 17, 2008 |
| APPL NO | 12/015957 |
| ART UNIT | 1714 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor 117/80 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323794 | Chu et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Cornell Research Foundation, Inc. (Ithaca, New York) |
| INVENTOR(S) | Chih-Chang Chu (Ithaca, New York); Xian-Zheng Zhang (Wuhan, China PRC); Da-Qing Wu (Ithaca, New York) |
| ABSTRACT | Injectable hydrogel microspheres are prepared by forming an emulsion where hydrogel precursors are in a disperse aqueous phase and polymerizing the hydrogel precursors. In a preferred case, the hydrogel precursors are poly(ethylene glycol) diacrylate and N-isopropylacrylamide and the continuous phase of the emulsion is an aqueous solution of dextran and a dextran solubility reducer. The microspheres will load protein, e.g., cytokines, from aqueous solution. |
| FILED | Thursday, August 12, 2010 |
| APPL NO | 12/855429 |
| ART UNIT | 1765 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Stock material or miscellaneous articles 428/402.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324703 | Parthangal et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Maryland (College Park, Maryland); The United States of America as represented by the Secretary of Commerce (Washington, District of Columbia) |
| INVENTOR(S) | Prahalad Parthangal (Galthersburg, Maryland); Michael R. Zachariah (Potomac, Maryland); Richard E. Cavicchi (Washington Grove, Maryland) |
| ABSTRACT | An in situ approach toward connecting and electrically contacting vertically aligned nanowire arrays using conductive nanoparticles is provided. The utility of the approach is demonstrated by development of a gas sensing device employing the nanowire assembly. Well-aligned, single-crystalline zinc oxide nanowires were grown through a direct thermal evaporation process at 550° C. on gold catalyst layers. Electrical contact to the top of the nanowire array was established by creating a contiguous nanoparticle film through electrostatic attachment of conductive gold nanoparticles exclusively onto the tips of nanowires. A gas sensing device was constructed using such an arrangement and the nanowire assembly was found to be sensitive to both reducing (methanol) and oxidizing (nitrous oxides) gases. This assembly approach is amenable to any nanowire array for which a top contact electrode is needed. |
| FILED | Tuesday, April 29, 2008 |
| APPL NO | 12/111696 |
| ART UNIT | 2815 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/438 |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 08323977 | Abramson et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | State of Oregon acting by and through the State Board of Higher Education on behalf of Portland State University (Portland, Oregon) |
| INVENTOR(S) | Jonathan J. Abramson (Beaverton, Oregon); Benjamin S. Marinov (Portland, Oregon) |
| ABSTRACT | A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the free radical cation and the free radical anion have been formed, the relative redox activity of the subject compound may cause a difference in the rate of photo-bleaching of the mixture and/or the rate of superoxide generation. These differences can be quantified and used to identify the redox activity of the subject compound. This sensitive technique for measuring redox activity can be used to screen compounds for various biological applications. Drugs also can be developed based on the relationship between redox activity and biological activity for particular biological applications. |
| FILED | Tuesday, August 09, 2011 |
| APPL NO | 13/206364 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326535 | Hoff |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Clean Power Research, L.L.C. (Napa, California) |
| INVENTOR(S) | Thomas E. Hoff (Napa, California) |
| ABSTRACT | A computer-implemented system and method for correlating overhead sky clearness for use in photovoltaic fleet output estimation is provided. A temporal distance that includes a physical distance between two locations, which are each within a geographic region suitable for operation of a photovoltaic fleet, is determined in proportion to cloud speed within the geographic region. A set of input sky clearness indexes is generated as a ratio of each irradiance observation in a set of irradiance observations that has been regularly measured for one of the locations within the geographic region, and clear sky irradiance. A clearness index correlation coefficient between the two locations is determined as an empirically-derived function of the temporal distance. The set of input sky clearness indexes is weighted by the clearness index correlation coefficient to form a set of output sky clearness indexes, which indicates the sky clearness for the other of the locations. |
| FILED | Monday, April 23, 2012 |
| APPL NO | 13/453937 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08326536 | Hoff |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Clean Power Research, L.L.C. (Napa, California) |
| INVENTOR(S) | Thomas E. Hoff (Napa, California) |
| ABSTRACT | A computer-implemented system and method for correlating satellite imagery for use in photovoltaic fleet output estimation is provided. Pixels in satellite imagery data of overhead sky clearness is correlated to a bounded area within a geographic region. Each pixel represents collective irradiance that is converted into point clearness indexes for the points within the bounded area relative to clear sky irradiance. The point clearness indexes in the point clearness indexes are averaged for the points within the bounded area into an area clearness index. A variance of the area clearness index is determined in proportion to a physical area covered by each pixel. For each point, a variance of the point clearness index is determined as a ratio of the area clearness index variance and the physical area relative to the point clearness index, regional cloud speed, and a time interval relating to a time resolution of collective irradiance observation. |
| FILED | Monday, April 23, 2012 |
| APPL NO | 13/453967 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 08322085 | Plumley |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger Dale Plumley (Crab Orchard, West Virginia) |
| ABSTRACT | A structure to protect occupants from storm debris comprising components that are pre-fabricated and assembled on site. Upon assembly, the void cavities in the floor, walls and ceilings are pumped with concrete to increase the unit strength and stability. |
| FILED | Wednesday, February 16, 2011 |
| APPL NO | 12/931979 |
| ART UNIT | 3635 — Static Structures, Supports and Furniture |
| CURRENT CPC | Static structures 052/79.140 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08323663 | Brough et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | GenVec, Inc. (Gaithersburg, Maryland) |
| INVENTOR(S) | Douglas E. Brough (Gaithersburg, Maryland); Joseph T. Bruder (Ijamsville, Maryland); C. Richter King (New York, New York); Marvin J. Grubman (Southold, New York); John G. Neilan (Wethersfield, Connecticut) |
| ABSTRACT | The invention is directed to an adenoviral vector comprising at least one nucleic acid sequence encoding an aphthovirus antigen and/or a cytokine operably linked to a promoter. The adenoviral vector is replication-deficient and requires at most complementation of both the E1 region and the E4 region of the adenoviral genome for propagation. The invention also is directed to a method of inducing an immune response in a mammal comprising administering to the mammal a composition comprising the aforementioned adenoviral vector. |
| FILED | Thursday, May 08, 2008 |
| APPL NO | 12/117513 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/233.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 08323668 | Fleckenstein |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The University of Tennessee Research Foundation (Knoxville, Tennessee) |
| INVENTOR(S) | James M. Fleckenstein (Memphis, Tennessee) |
| ABSTRACT | The present invention describes a novel mechanism of adhesion by flagellated Gram-negative bacteria such as enterotoxigenic Escherichia coli (ETEC), where the bacteria secretes a protein, EtpA which binds to the conserved region of the flagellin protein located at the tip of the flagella. The present invention also discloses that EtpA-mediated interaction and intestinal colonization require interaction with flagellin. Also disclosed herein is a vaccine composition that can be used for either active or passive immunization of mammals for the prevention or treatment of infections caused by flagellated Gram-negative bacteria. |
| FILED | Wednesday, March 26, 2008 |
| APPL NO | 12/079304 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/257.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08324178 | Simpson, Jr. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Paul C. Simpson, Jr. (San Francisco, California) |
| ABSTRACT | Methods for treating or preventing cardiomyopathy in a subject by administering an α1 adrenergic receptor agonist, wherein the treatment does not result in increased blood pressure are provided. |
| FILED | Monday, November 02, 2009 |
| APPL NO | 12/610720 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/34 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 08322267 | Altergott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Triton Systems, Inc. (Chelmsford, Massachusetts) |
| INVENTOR(S) | William Altergott (Uxbridge, Massachusetts); Thomas J. Carroll (Salem, New Hampshire); James J. Gorman (Boxborough, Massachusetts); George Santiago (Marlborough, Massachusetts) |
| ABSTRACT | An armor repair kit including repair putty and a scrim having a plurality of ceramic constituents attached thereto and methods for using a repair putty, scrims and kits to repair damaged armor are described herein. |
| FILED | Wednesday, June 03, 2009 |
| APPL NO | 12/477355 |
| ART UNIT | 3633 — Static Structures, Supports and Furniture |
| CURRENT CPC | Ordnance 089/36.20 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08322528 | Sterns |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony A. Sterns (Akron, Ohio) |
| ABSTRACT | A pillbox that can be used with a portable electronic device (“PED”) such as a cellular telephone or personal digital assistant includes a generally cubic body portion that is attached to one end of a PED. The body portion defines a compartment within which medication can be placed. Preferably, an extension projects from one wall of the body portion and the extension is connected to the PED. The body portion preferably conforms generally to the contour of the PED. A door is connected to the body portion to permit selective access to the compartment. Other embodiments of the invention include a holster within which the PED can be inserted. In some of the embodiments, the door defines the medication-storage compartment. |
| FILED | Monday, January 28, 2008 |
| APPL NO | 12/020813 |
| ART UNIT | 3788 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Special receptacle or package 26/320 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 08323706 | Cleveland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Tulane Educational Fund (New Orleans, Louisiana) |
| INVENTOR(S) | Thomas E. Cleveland (Mandeville, Louisiana); Stephen M. Boue (New Orleans, Louisiana); Matthew E. Burow (Slidell, Louisiana); John A. McLachlan (New Orleans, Louisiana) |
| ABSTRACT | The flavonoid family of phytochemicals, particularly those derived from soy, has received attention regarding their hormonal activity and their effects on human health and disease. The types and amounts of these compounds in soy and other plants are controlled by both constitutive expression and stress-induced biosynthesis. The health benefits of soy may therefore be dependent upon the amounts of the various hormonally active phytochemicals present. We have identified increased biosynthesis of the isoflavonoid phytoalexin compounds, Glyceollins I, II and III, in soy plants grown under stressed conditions (elicited soy), which exhibit marked anti-estrogenic effects on ER function. Here we demonstrate that specific glyceollins, isolated from elicited soy, displayed anti-estrogenic activity, suppressing basal and estrogen stimulated colony formation of ER-positive estrogen dependent breast cancer cells and inhibiting ER-dependent gene expression of progesterone receptor (PgR) and stromal derived factor-1 (SDF1/CXCL12). Examining the effects of glyceollin on in vivo tumor formation/growth we demonstrate the ability of glyceollins to significantly suppress basal and estrogen-stimulated tumor growth of ER-positive MCF-7 breast and BG-1 ovarian carcinoma cells in ovariectomized female nude mice. We further demonstrate that the effects of glyceollins on suppression of tumor growth correlate with inhibition of estrogen stimulated PgR expression. In contrast to the uterotropic activity of tamoxifen the glyceollins displayed no uterine agonist activity. The Glyceollin (I-III) compounds may represent an important component of the health effects of soy as well as represent novel anti-estrogens useful in the prevention or treatment of breast and ovarian carcinoma. |
| FILED | Friday, April 11, 2008 |
| APPL NO | 12/082583 |
| ART UNIT | 1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/725 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 08324858 | Hill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Proterra Inc. (Greenville, South Carolina) |
| INVENTOR(S) | Dale Hill (Evergreen, Colorado); Michael Walker (Thornton, Colorado); Joshua Goldman (San Diego, California); John Horth (Evergreen, Colorado) |
| ABSTRACT | The invention relates to systems and methods for charging a vehicle. A vehicle and charging station can be designed such that an electric or hybrid vehicle can operate in a fashion similar to a conventional vehicle by being opportunity charged throughout a known route. |
| FILED | Wednesday, July 01, 2009 |
| APPL NO | 12/496569 |
| ART UNIT | 2859 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Battery or capacitor charging or discharging 320/109 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 08324125 | Varma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the U.S. Environmental Protection Agency (Washington, District of Columbia) |
| INVENTOR(S) | Rajender S. Varma (Cincinnati, Ohio); Vivek Polshettiwar (Cincinnati, Ohio) |
| ABSTRACT | This invention relates to the use of nano-organocatalysts, and, more specifically, to the use of magnetic nanomaterial-supported organocatalysts. It is an object of the present invention to provide “green” catalysts and protocols. According to one embodiment of the invention, a nano-organocatalyst in the form of a magnetic nanomaterial-supported organocatalyst is provided. According to other embodiments of the invention, glutathione and cysteine are provided as organocatalysts and magnetic nanomaterial-supported glutathione and magnetic nanomaterial-supported cysteine are provided for use as nano-organocatalysts. According to another embodiment of the invention, a method of using a recyclable magnetic nanomaterial-supported organocatalyst using a totally benign aqueous protocol, without using any organic solvent in the reaction or during the workup, is provided. According to a further embodiment of the invention, a recyclable magnetic nanomaterial-supported organocatalyst for various organocatalytic reactions, including but not limited to Paal-Knorr reactions, aza-Michael addition and pyrazole synthesis, is provided. |
| FILED | Thursday, September 03, 2009 |
| APPL NO | 12/553681 |
| ART UNIT | 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Catalyst, solid sorbent, or support therefor: Product or process of making 52/150 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 08326821 | Andrade et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Henrique Andrade (Croton-on-Hudson, New York); Bugra Gedik (Hawthorne, New York); Martin J. Hirzel (Hawthorne, New York); Robert Soule (Hawthorne, New York); Hua Yong Wang (Beijing, China PRC); Kun-Lung Wu (Hawthorne, New York); Qiong Zou (Beijing, China PRC) |
| ABSTRACT | A method of transforming relational queries of a database into on a data processing system includes receiving a series of relational queries, transforming first parts of the queries into a continuous query embodied as a streaming application, sending parameters in second parts of the queries in the series to the streaming application as a data stream, and executing the continuous query based on the received data stream to generate query results for the series of relational queries. Each query in the series includes a first part and a second part. The first parts are a pattern common to all the queries in the series and the second parts each have one or more parameters that are not common to all of the queries in the series. |
| FILED | Wednesday, August 25, 2010 |
| APPL NO | 12/868344 |
| ART UNIT | 2162 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/713 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 08324589 | Rubenstein |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Advanced Fuel Research, Inc. (East Hartford, Connecticut) |
| INVENTOR(S) | Eric P. Rubenstein (East Hartford, Connecticut) |
| ABSTRACT | Digital images or the charge from pixels in light sensitive semiconductor based imagers may be used to detect gamma rays and energetic particles emitted by radioactive materials. Methods may be used to identify pixel-scale artifacts introduced into digital images and video images by high energy gamma rays. Statistical tests and other comparisons on the artifacts in the images or pixels may be used to prevent false-positive detection of gamma rays. The sensitivity of the system may be used to detect radiological material at distances in excess of 50 meters. Advanced processing techniques allow for gradient searches to more accurately determine the source's location, while other acts may be used to identify the specific isotope. Coordination of different imagers and network alerts permit the system to separate non-radioactive objects from radioactive objects. |
| FILED | Thursday, December 08, 2011 |
| APPL NO | 13/314801 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Radiant energy 250/395 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 08324538 | Schwerman |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Honeywell International Inc. (Morristown, New Jersey) |
| INVENTOR(S) | Paul Schwerman (Phoenix, Arizona) |
| ABSTRACT | Systems and methods to source a resistive load, such as a heating resistor, to control temperature while adhering to a specified power draw budget and/or a specified root mean square (RMS) current limit. For example, a sensor block assembly (SBA) heater controls temperature of a MEMS device in a sensor block assembly while adhering to the power draw budget and/or an average current limit. An exemplary embodiment generates a pulse width modulation (PWM) control signal, controls a switch in accordance with the control signal, sources the resistive load from a power source in accordance with the controlled switch, and modifies the duty factor of the switch to reduce the power drawn by the resistive load in response to the power drawn by the resistive load exceeding a power limit defined by a slope-intercept curve. The limiting of power into a resistor load limits the RMS current drawn by that load. |
| FILED | Tuesday, November 10, 2009 |
| APPL NO | 12/616083 |
| ART UNIT | 2827 — Semiconductors/Memory |
| CURRENT CPC | Electric heating 219/490 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325086 | Stafford et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Stephen J. Stafford (Derwood, Maryland); Mark S. Asher (Ellicott City, Maryland); Martin G. Sommerville (Columbia, Maryland); Lloyd A. Linstrom (Columbia, Maryland); Thomas L. Kusterer (Elkridge, Maryland) |
| ABSTRACT | Methods and systems to detect navigation signals, including to identify up to multiple range-Doppler hypotheses from each of j range-Doppler correlation grids based on a relatively low first threshold, generate navigation solutions from combinatorial sets of k of the identified hypotheses, evaluate the navigation solutions to identify plausible solutions, iteratively and combinatorially augment the plausible solutions with additional hypotheses from grids that are not represented in the corresponding k-hypotheses based navigation solutions, replace plausible solutions with corresponding augmented plausible solutions when appropriate, and select one of a plurality of plausible solutions as a best plausible solution, j and k being positive integers. Where a grid energy peak exceeds a second threshold, a corresponding hypothesis may be identified as a sole hypothesis for the corresponding navigation signal. The relatively low first threshold permits detection of weaker signals. Subsequent evaluations effectively transform a per-navigation-signal false alarm rate to per-navigation-solution false alarm rate. |
| FILED | Monday, April 26, 2010 |
| APPL NO | 12/767158 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Communications: Directive radio wave systems and devices 342/357.250 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08325507 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Hewlett-Packard Development Company, L.P. (Houston, Texas) |
| INVENTOR(S) | Jianhua Yang (Palo Alto, California); Wei Yi (Mountain View, California); Michael Josef Stuke (Palo Alto, California); Shih-Yuan Wang (Palo Alto, California) |
| ABSTRACT | A memristor includes a first electrode of a nanoscale width; a second electrode of a nanoscale width; and an active region disposed between the first and second electrodes. The active region has a both a non-conducting portion and a source of dopants portion induced by electric field. The non-conducting portion comprises an electronically semiconducting or nominally insulating material and a weak ionic conductor switching material capable of carrying a species of dopants and transporting the dopants under an electric field. The non-conducting portion is in contact with the first electrode and the source of dopants portion is in contact with the second electrode. The second electrode comprises a metal reservoir for the dopants. A crossbar array comprising a plurality of the nanoscale switching devices is also provided. A process for making at least one nanoscale switching device is further provided. |
| FILED | Wednesday, September 29, 2010 |
| APPL NO | 12/893825 |
| ART UNIT | 2826 — Semiconductors/Memory |
| CURRENT CPC | Static information storage and retrieval 365/148 |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, December 04, 2012.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2012/fedinvent-patents-20121204.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page