FedInvent™ Patents

Patent Details for Tuesday, January 15, 2013 

This page was updated on Monday, March 27, 2023 at 03:43 AM GMT

Department of Defense (DOD) 

US 08353199 Ma et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Ou Ma (Las Cruces, New Mexico);  Carlos E. Ortega (Las Cruces, New Mexico);  Ken Ruble (Chaparral, New Mexico);  Qi Lu (Pudong, China PRC)
ASSIGNEE(S) Arrowhead Center, Inc. (Las Cruces, New Mexico)
INVENTOR(S) Ou Ma (Las Cruces, New Mexico);  Carlos E. Ortega (Las Cruces, New Mexico);  Ken Ruble (Chaparral, New Mexico);  Qi Lu (Pudong, China PRC)
ABSTRACT The invention is a multiple degree-of-freedom test stand for unmanned air vehicles, and is particularly useful for small or micro unmanned air vehicles. The stand is gravity balanced using springs such that no weight of any part of the stand becomes a burden to the tested vehicle when it flies while constrained to the stand. A joint and a plurality of members are used to enable multiple degrees of freedom.
FILED Monday, April 19, 2010
APPL NO 12/762981
ART UNIT 2856 — Printing/Measuring and Testing
CURRENT CPC
Measuring and testing
073/65.50
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08353222 Petruska et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Andrew J. Petruska (North Ogden, Utah);  Jeffrey R. Nostrom (Tremonton, Utah);  Amy M. Baesler (Ogden, Utah);  Rick R. Baird (Tremonton, Utah)
ASSIGNEE(S) Alliant Techsystems Inc. (Arlington, Virginia)
INVENTOR(S) Andrew J. Petruska (North Ogden, Utah);  Jeffrey R. Nostrom (Tremonton, Utah);  Amy M. Baesler (Ogden, Utah);  Rick R. Baird (Tremonton, Utah)
ABSTRACT A testing apparatus and related methods are disclosed. In one embodiment, the testing apparatus may include a platform, a first plurality of cables, a second plurality of cables and a third plurality of cables, with each of the cables coupled to a respective load cell. The first plurality of cables may suspend the platform and be substantially parallel to each other. The second plurality of cables may be coupled to the platform, may be substantially parallel to each other cable of the second plurality of cables, and substantially perpendicular to each cable of the first plurality of cables. The third plurality of cables may be coupled to the platform, and each cable of the third plurality of cables may be substantially parallel to each other cable of the third plurality of cables, and substantially perpendicular to each cable of the first plurality of cables and the second plurality of cables.
FILED Wednesday, June 09, 2010
APPL NO 12/797127
ART UNIT 2856 — Printing/Measuring and Testing
CURRENT CPC
Measuring and testing
073/862.41
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08353329 Gleiner et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
APPLICANT(S) Matthew S. Gleiner (Vernon, Connecticut);  Matthew A. Devore (Cromwell, Connecticut)
ASSIGNEE(S) United Technologies Corporation (Hartford, Connecticut)
INVENTOR(S) Matthew S. Gleiner (Vernon, Connecticut);  Matthew A. Devore (Cromwell, Connecticut)
ABSTRACT A core for creating an airfoil has a ceramic material that forms a body. The body has an outer dimension, a slot extending through the outer dimension and into the body for receiving an insert, the slot disposed at an angle to the outer dimension, and a trip strip having a first portion disposed in the outer dimension. The first portion is in register with the slot wherein a constant dimension such as minimum thickness is maintained between the trip strip and the slot along a length of the slot and wherein said first portion tapers towards said outer dimension.
FILED Monday, May 24, 2010
APPL NO 12/786066
ART UNIT 1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Metal founding
164/369
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08353373 Rudakevych
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Pavlo E. Rudakevych (Arroyo Grande, California)
ASSIGNEE(S) iRobot Corporation (Bedford, Massachusetts)
INVENTOR(S) Pavlo E. Rudakevych (Arroyo Grande, California)
ABSTRACT A mobile robot includes a robot chassis having a forward end, a rearward end and a center of gravity. The robot includes a driven support surface to propel the robot and first articulated arm rotatable about an axis located rearward of the center of gravity of the robot chassis. The arm is pivotable to trail the robot, rotate in a first direction to raise the rearward end of the robot chassis while the driven support surface propels the chassis forward in surmounting an obstacle, and to rotate in a second opposite direction to extend forward beyond the center of gravity of the robot chassis to raise the forward end of the robot chassis and invert the robot endwise.
FILED Monday, December 12, 2011
APPL NO 13/323019
ART UNIT 3611 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Motor vehicles
180/9.320
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08353480 Sadeck et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) James E. Sadeck (East Freetown, Massachusetts);  Justin Riley (Grafton, Massachusetts);  Kenneth J. Desabrais (Brimfield, Massachusetts);  Calvin Lee (Needham, Massachusetts)
ASSIGNEE(S) The United States Government as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S) James E. Sadeck (East Freetown, Massachusetts);  Justin Riley (Grafton, Massachusetts);  Kenneth J. Desabrais (Brimfield, Massachusetts);  Calvin Lee (Needham, Massachusetts)
ABSTRACT A concentric peripheral canopy parachute having a canopy system including a number of peripheral, stacked, concentric, canopies, each superior canopy centered and spaced above the inferior canopy and having its skirt connected to the vent of the inferior canopy for generating an increased low pressure disturbance behind the canopy system for producing higher fluid drag.
FILED Tuesday, June 01, 2010
APPL NO 12/791142
ART UNIT 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Aeronautics and astronautics
244/145
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08353669 Chon et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Air Systems Command (NAVAIR)
APPLICANT(S) Young H. Chon (West Hartford, Connecticut);  Dominic J. Mongillo (West Hartford, Connecticut);  Tracy A. Propheter-Hinckley (Manchester, Connecticut)
ASSIGNEE(S) United Technologies Corporation (Hartford, Connecticut)
INVENTOR(S) Young H. Chon (West Hartford, Connecticut);  Dominic J. Mongillo (West Hartford, Connecticut);  Tracy A. Propheter-Hinckley (Manchester, Connecticut)
ABSTRACT A vane for use in a gas turbine engine has a platform connected to an airfoil. There is a cooling passage for supplying cooling air to the platform. A cooling chamber supplies cooling air to a plurality of cooling slots at the platform. The cooling slots have a non-uniform cross section.
FILED Tuesday, August 18, 2009
APPL NO 12/542918
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Fluid reaction surfaces
416/96.R00
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08353673 Leahy et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Kevin P. Leahy (Naugatuck, Connecticut);  Richard Joseph Simkulak (Meriden, Connecticut);  David A. Kovalsky (Huntington, Connecticut)
ASSIGNEE(S) Sikorsky Aircraft Corporation (Stratford, Connecticut)
INVENTOR(S) Kevin P. Leahy (Naugatuck, Connecticut);  Richard Joseph Simkulak (Meriden, Connecticut);  David A. Kovalsky (Huntington, Connecticut)
ABSTRACT A main rotor blade assembly includes a main spar with an integral cuff. The main spar is directly to a rotor hub assembly through the integral cuff.
FILED Saturday, April 26, 2008
APPL NO 12/110312
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Fluid reaction surfaces
416/226
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354011 Elangovan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
Idaho National Laboratory (INL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S) S. Elangovan (South Jordan, Utah);  Joseph J. Hartvigsen (Kaysville, Utah);  Feng Zhao (Salt Lake City, Utah)
ASSIGNEE(S) Ceramatec, Inc. (Salt Lake City, Utah)
INVENTOR(S) S. Elangovan (South Jordan, Utah);  Joseph J. Hartvigsen (Kaysville, Utah);  Feng Zhao (Salt Lake City, Utah)
ABSTRACT An electrolyzer cell is disclosed which includes a cathode to reduce an oxygen-containing molecule, such as H2O, CO2, or a combination thereof, to produce an oxygen ion and a fuel molecule, such as H2, CO, or a combination thereof. An electrolyte is coupled to the cathode to transport the oxygen ion to an anode. The anode is coupled to the electrolyte to receive the oxygen ion and produce oxygen gas therewith. In one embodiment, the anode may be fabricated to include an electron-conducting phase having a perovskite crystalline structure or structure similar thereto. This perovskite may have a chemical formula of substantially (Pr(1-x)Lax)(z-y)A′yBO(3-∂), wherein 0<x<1, 0≦y≦0.5, and 0.8≦z≦1.1. In another embodiment, the cathode includes an electron-conducting phase that contains nickel oxide intermixed with magnesium oxide.
FILED Friday, November 19, 2010
APPL NO 12/950120
ART UNIT 1759 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC
Chemistry: Electrical and wave energy
24/266
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354052 Guenthner et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Andrew J. Guenthner (Lancaster, California);  David Michael Hess (Redondo Beach, California)
ASSIGNEE(S) The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S) Andrew J. Guenthner (Lancaster, California);  David Michael Hess (Redondo Beach, California)
ABSTRACT A microconduit network structure and methods for making the same. One aspect of the invention relates to a microconduit network structure, including: a solid or semi-solid matrix having at least one interconnected web of filaments formed within the matrix; and wherein at least one interconnected web of filaments having diameters of about 10 nm to about 1 mm.
FILED Tuesday, January 26, 2010
APPL NO 12/694090
ART UNIT 1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC
Plastic and nonmetallic article shaping or treating: Processes
264/465
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354076 Daniel et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Jürgen H. Daniel (San Francisco, California);  Meng H. Lean (Santa Clara, California);  Armin R. Völkel (Mountain View, California)
ASSIGNEE(S) Palo Alto Research Center Incorporated (, None)
INVENTOR(S) Jürgen H. Daniel (San Francisco, California);  Meng H. Lean (Santa Clara, California);  Armin R. Völkel (Mountain View, California)
ABSTRACT A fluidic system and method includes a channel reservoir which holds 1.5 milliliters or less of fluid. The agitation mechanism, which is partially integrated with the channel or reservoir, includes a fiber or rod at least partially situated within the channel or reservoir, and which acts to move or vibrate to stir and/or agitate fluid within the channel or reservoir. The fluid is then extracted from an extraction area following the agitation or stirring operation.
FILED Monday, October 02, 2006
APPL NO 11/537679
ART UNIT 1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing
422/503
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354166 Tan et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Daniel Qi Tan (Rexford, New York);  George Theodore Dalakos (Niskayuna, New York);  Yang Cao (Niskayuna, New York);  Qin Chen (Schenectady, New York);  Ri-an Zhao (Niskayuna, New York)
ASSIGNEE(S) General Electric Company (Niskayuna, New York)
INVENTOR(S) Daniel Qi Tan (Rexford, New York);  George Theodore Dalakos (Niskayuna, New York);  Yang Cao (Niskayuna, New York);  Qin Chen (Schenectady, New York);  Ri-an Zhao (Niskayuna, New York)
ABSTRACT Present invention provides a film and an article including the film. The film includes first layer, second layer and third layer. The first layer includes a polymer dielectric material. The second layer is disposed on at least one surface of the first layer and includes inorganic oxide dielectric material. The third layer is disposed on the first or second layer and includes a nitride or oxynitride material.
FILED Monday, February 28, 2011
APPL NO 13/036089
ART UNIT 1787 — Miscellaneous Articles, Stock Material
CURRENT CPC
Stock material or miscellaneous articles
428/332
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354170 Henry et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
APPLICANT(S) Christopher P. Henry (Thousand Oaks, California);  Geoffrey P. McKnight (Los Angeles, California)
ASSIGNEE(S) HRL Laboratories, LLC (Malibu, California)
INVENTOR(S) Christopher P. Henry (Thousand Oaks, California);  Geoffrey P. McKnight (Los Angeles, California)
ABSTRACT An engineered microstructure composite having an elastic or elastomeric matrix with distributed rigid reinforcements. One embodiment of the invention provides an elastomeric composite including an elastomeric matrix, a plurality of rigid reinforcements embedded within the elastomeric matrix, and a plurality of attachments (or ligaments) connected to the reinforcements to interconnect the rigid reinforcements to each other. Here, in this embodiment, the elastomeric composite has a composite reversible strain limit greater than 3 percent (%) (or, in one embodiment, greater than 5%) due to kinematics of the rigid reinforcements interconnected by the attachments and embedded within the elastomeric matrix.
FILED Tuesday, October 06, 2009
APPL NO 12/587469
ART UNIT 1786 — Miscellaneous Articles, Stock Material
CURRENT CPC
Stock material or miscellaneous articles
428/457
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354231 Kwong et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Gabriel A. Kwong (Alhambra, California);  Ryan C. Bailey (Urbana, Illinois);  Rong Fan (Pasadena, California);  James R. Heath (South Pasadena, California)
ASSIGNEE(S) Cal. Inst. Tech. (Pasadena, California)
INVENTOR(S) Gabriel A. Kwong (Alhambra, California);  Ryan C. Bailey (Urbana, Illinois);  Rong Fan (Pasadena, California);  James R. Heath (South Pasadena, California)
ABSTRACT Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.
FILED Monday, January 04, 2010
APPL NO 12/652000
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/6.120
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354239 Gaylord et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) Brent S. Gaylord (Santa Barbara, California);  Janice W. Hong (Santa Barbara, California);  Tsu-Ju Fu (Poway, California);  Cheng-Jun Sun (Goleta, California);  Russell Baldocchi (Santa Barbara, California)
ASSIGNEE(S) Sirigen, Inc. (San Diego, California)
INVENTOR(S) Brent S. Gaylord (Santa Barbara, California);  Janice W. Hong (Santa Barbara, California);  Tsu-Ju Fu (Poway, California);  Cheng-Jun Sun (Goleta, California);  Russell Baldocchi (Santa Barbara, California)
ABSTRACT Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.
FILED Monday, August 01, 2011
APPL NO 13/195736
ART UNIT 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/7.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354290 Sumant et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) Anirudha V. Sumant (Argonne, Illinois);  Orlando H. Auciello (Lemont, Illinois);  Derrick C. Mancini (Argonne, Illinois)
ASSIGNEE(S) UChicago Argonne, LLC (Argonne, Illinois)
INVENTOR(S) Anirudha V. Sumant (Argonne, Illinois);  Orlando H. Auciello (Lemont, Illinois);  Derrick C. Mancini (Argonne, Illinois)
ABSTRACT An efficient deposition process is provided for fabricating reliable RF MEMS capacitive switches with multilayer ultrananocrystalline (UNCD) films for more rapid recovery, charging and discharging that is effective for more than a billion cycles of operation. Significantly, the deposition process is compatible for integration with CMOS electronics and thereby can provide monolithically integrated RF MEMS capacitive switches for use with CMOS electronic devices, such as for insertion into phase array antennas for radars and other RF communication systems.
FILED Tuesday, April 05, 2011
APPL NO 13/080255
ART UNIT 2897 — Semiconductors/Memory
CURRENT CPC
Semiconductor device manufacturing: Process
438/53
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354332 Ayazi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) Farrokh Ayazi (Atlanta, Georgia);  Ashwin Samarao (Atlanta, Georgia)
ASSIGNEE(S) Georgia Tech Research Corporation (Atlanta, Georgia)
INVENTOR(S) Farrokh Ayazi (Atlanta, Georgia);  Ashwin Samarao (Atlanta, Georgia)
ABSTRACT A micro-electromechanical resonator includes a resonator body having a semiconductor region therein doped with boron to a level greater than about 1×1018 cm−3 and even greater than about 1×1019 cm−3, in order to obtain reductions in the temperature coefficient of frequency (TCF) of the resonator over a relatively large temperature range. Still further improvements in TCF can be achieved by degenerately doping the resonator body with boron and/or by boron-assisted aluminum doping of the resonator body.
FILED Wednesday, September 30, 2009
APPL NO 12/570623
ART UNIT 2896 — Semiconductors/Memory
CURRENT CPC
Semiconductor device manufacturing: Process
438/510
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354390 Bavari et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Sina Bavari (Frederick, Maryland);  Kelly Lyn Warfield (Adamstown, Maryland);  Pamela Tan (Kulmbach, Germany);  Anna Borodovsky (Cambridge, Massachusetts);  Tatiana Novobrantseva (Wellesley, Massachusetts);  Antonin de Fougerolles (Brookline, Massachusetts)
ASSIGNEE(S) Alnylam Pharmaceuticals, Inc. (Cambridge, Massachusetts);  The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S) Sina Bavari (Frederick, Maryland);  Kelly Lyn Warfield (Adamstown, Maryland);  Pamela Tan (Kulmbach, Germany);  Anna Borodovsky (Cambridge, Massachusetts);  Tatiana Novobrantseva (Wellesley, Massachusetts);  Antonin de Fougerolles (Brookline, Massachusetts)
ABSTRACT The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
FILED Monday, April 25, 2011
APPL NO 13/093681
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/44.A00
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354595 Rolston et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
APPLICANT(S) Kevin C. Rolston (Westchester, California);  Alberto F. Viscarra (Torrance, California);  Derek Pruden (Redondo Beach, California);  Cindy W. Ma (Lawndale, California)
ASSIGNEE(S) Raytheon Company (Waltham, Massachusetts)
INVENTOR(S) Kevin C. Rolston (Westchester, California);  Alberto F. Viscarra (Torrance, California);  Derek Pruden (Redondo Beach, California);  Cindy W. Ma (Lawndale, California)
ABSTRACT A method for interconnecting a first flex printed circuit board (PCB) with a second flex PCB. The method includes: providing the first flex PCB with holes at contact locations to be electrically coupled to the second flex PCB; providing the second flex PCB with electrical pads corresponding to the holes at the contact locations; applying a non-conductive material between the first PCB and the and second PCB with clearances for each of the electrical pads; aligning the first PCB with the second PCB so that the holes in the first PCB are in line with the corresponding electrical pads on the second PCB; bonding a portion of flat areas on the first and second PCBs together; dispensing a conductive adhesive into the holes to fill the space created by the holes, corresponding clearances of the non-conductive material, and the corresponding electrical pads; and curing the conductive adhesive.
FILED Wednesday, April 21, 2010
APPL NO 12/764854
ART UNIT 2835 — Electrical Circuits and Systems
CURRENT CPC
Electricity: Conductors and insulators
174/254
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354689 Chua et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Christopher L. Chua (San Jose, California);  Zhihong Yang (San Jose, California)
ASSIGNEE(S) Palo Alto Research Center Incorporated (Palo Alto, California)
INVENTOR(S) Christopher L. Chua (San Jose, California);  Zhihong Yang (San Jose, California)
ABSTRACT Light emitting devices described herein include dopant front loaded tunnel barrier layers (TBLs). A front loaded TBL includes a first surface closer to the active region of the light emitting device and a second surface farther from the active region. The dopant concentration in the TBL is higher near the first surface of the TBL when compared to the dopant concentration near the second surface of the TBL. The front loaded region near the first surface of the TBL is formed during fabrication of the device by pausing the growth of the light emitting device before the TBL is formed and flowing dopant into the reaction chamber. After the dopant flows in the reaction chamber during the pause, the TBL is grown.
FILED Thursday, April 28, 2011
APPL NO 13/097001
ART UNIT 2826 — Semiconductors/Memory
CURRENT CPC
Active solid-state devices
257/101
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354690 Callanan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Robert J. Callanan (Raleigh, North Carolina);  Sei-Hyung Ryu (Cary, North Carolina);  Qingchun Zhang (Cary, North Carolina)
ASSIGNEE(S) Cree, Inc. (Durham, North Carolina)
INVENTOR(S) Robert J. Callanan (Raleigh, North Carolina);  Sei-Hyung Ryu (Cary, North Carolina);  Qingchun Zhang (Cary, North Carolina)
ABSTRACT Provided is a semiconductor bistable switching device that includes a thyristor portion including an anode layer, a drift layer, a gate layer and a cathode layer, the gate layer operable to receive a gate trigger current that, when the anode layer is positively biased relative to the cathode layer, causes the thyristor portion to latch into a conducting mode between the anode and the cathode. The device also includes a transistor portion formed on the thyristor portion, the transistor portion including a source, a drain and a transistor gate, the drain coupled to the cathode of the thyristor portion.
FILED Monday, August 31, 2009
APPL NO 12/550574
ART UNIT 2822 — Semiconductors/Memory
CURRENT CPC
Active solid-state devices
257/121
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354737 Andry et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Security Agency (NSA)
APPLICANT(S) Paul S Andry (Yorktown Heights, New York);  John M Cotte (New Fairfield, Connecticut);  John Ulrich Knickerbocker (Monroe, New York);  Cornelia K Tsang (Mohegan Lake, New York)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) Paul S Andry (Yorktown Heights, New York);  John M Cotte (New Fairfield, Connecticut);  John Ulrich Knickerbocker (Monroe, New York);  Cornelia K Tsang (Mohegan Lake, New York)
ABSTRACT A semiconductor structure includes: at least one silicon surface wherein the surface can be a substrate, wafer or other device. The structure further includes at least one electronic circuit formed on each side of the at least one surface; and at least one conductive high aspect ratio through silicon via running through the at least one surface. Each through silicon via is fabricated from at least one etch step and includes: at least one thermal oxide dielectric for coating at least some of a sidewall of the through silicon via for a later etch stop in fabrication of the through silicon via.
FILED Monday, January 03, 2011
APPL NO 12/983552
ART UNIT 2892 — Semiconductors/Memory
CURRENT CPC
Active solid-state devices
257/621
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354743 Jensen et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
APPLICANT(S) Ronald James Jensen (Bloomington, Minnesota);  David Scheid (Eau Claire, Wisconsin)
ASSIGNEE(S) Honeywell International Inc. (Morristown, New Jersey)
INVENTOR(S) Ronald James Jensen (Bloomington, Minnesota);  David Scheid (Eau Claire, Wisconsin)
ABSTRACT An integrated circuit package base includes a plurality of tiers. In some examples, an integrated circuit package encloses a plurality of stacked integrated circuits that are each electrically coupled to an electrical contact located on a respective tier of the package base. The tiers of the integrated circuit package can have different elevations relative to a bottom surface of the integrated circuit package.
FILED Wednesday, January 27, 2010
APPL NO 12/694898
ART UNIT 2896 — Semiconductors/Memory
CURRENT CPC
Active solid-state devices
257/686
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354858 Cannon et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Ethan H. Cannon (Essex Junction, Vermont);  AJ KleinOsowski (Austin, Texas);  K. Paul Muller (Wappingers Falls, New York);  Tak H. Ning (Yorktown Heights, New York);  Philip J. Oldiges (LaGrangeville, New York);  Leon J. Sigal (Monsey, New York);  James D. Warnock (Somers, New York);  Dieter Wendel (Schoenaich, Germany)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) Ethan H. Cannon (Essex Junction, Vermont);  AJ KleinOsowski (Austin, Texas);  K. Paul Muller (Wappingers Falls, New York);  Tak H. Ning (Yorktown Heights, New York);  Philip J. Oldiges (LaGrangeville, New York);  Leon J. Sigal (Monsey, New York);  James D. Warnock (Somers, New York);  Dieter Wendel (Schoenaich, Germany)
ABSTRACT A method of determining one or more transistors within a particular circuit to be respectively replaced with a hardened transistor includes: identifying, as not requiring hardening, one or more transistors; identifying, as candidates for hardening, each transistor in the circuit not previously identified as not requiring hardening; and employing the hardened transistor in place of a transistor identified as a candidate for hardening. The circuit is a latch and the transistor is an SOI CMOS FET. The transistor is also an SOI transistor. The series transistor includes first and second series-connected transistors having a shared source/drain region whereby a drain of the first series-connected transistor is merged with a source of the second series-connected transistor.
FILED Saturday, January 08, 2011
APPL NO 12/987106
ART UNIT 2858 — Printing/Measuring and Testing
CURRENT CPC
Electricity: Measuring and testing
324/762.90
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354885 Griffith et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S) Zachary M. Griffith (Thousand Oaks, California);  Miguel E. Urteaga (Moorpark, California);  Mark J. W. Rodwell (Santa Barbara, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  Teledyne Scientific and Imaging, LLC (Thousand Oaks, California)
INVENTOR(S) Zachary M. Griffith (Thousand Oaks, California);  Miguel E. Urteaga (Moorpark, California);  Mark J. W. Rodwell (Santa Barbara, California)
ABSTRACT An operational amplifier may include a transimpedance input stage. The operational amplifier is capable of self-biasing its input voltage(s) including a first stage, an input source connected to the first stage, an output stage connected to the first stage via feedback resistors, and feedback current sources connected to the first stage, wherein the feedback current sources are set to generate feedback currents flowing from the output stage back to the input stage via the feedback resistors, so as to self-bias the input voltage(s) at the input stage. A method for allowing for an op-amp to self-bias its input voltage(s), including generating feedback currents flowing from the output stage back to the input stage via feedback resistors, so as to self-bias the input voltage(s) at the input stage.
FILED Friday, May 25, 2012
APPL NO 13/481312
ART UNIT 2817 — Semiconductors/Memory
CURRENT CPC
Amplifiers
330/260
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354929 Herdic et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Peter C Herdic (Washington, District of Columbia);  Robert M Baden (Yamaguchi, Japan);  Brian H Houston (Fairfax, Virginia);  Phillip A Frank (Laurel, Maryland);  Alain R Berdoz (Annandale, Virginia);  Jeff M Byers (Fairfax Station, Virginia)
ASSIGNEE(S) The United States of America, as respresented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S) Peter C Herdic (Washington, District of Columbia);  Robert M Baden (Yamaguchi, Japan);  Brian H Houston (Fairfax, Virginia);  Phillip A Frank (Laurel, Maryland);  Alain R Berdoz (Annandale, Virginia);  Jeff M Byers (Fairfax Station, Virginia)
ABSTRACT A method and system for detecting and classifying intruders is provided. A noise threshold can be determined and set based on background noise. A seismic sensor can be configured to receive a plurality of seismic data signals. A microcontroller can be configured to count the number of times the noise threshold is exceeded over a defined time interval by the plurality of seismic data signals, and then detect and classify the presence of an intruder based on the count. Additionally, an amplitude evaluation module can be configured to determine a signal amplitude for the seismic data signals associated with the detected intruder and compare the detected intruder signal amplitude to known signal amplitudes in order to determine a sub-type of the intruder. Finally, a transmission source can be configured to transmit intruder detection and classification information to a remote location.
FILED Wednesday, September 09, 2009
APPL NO 12/555918
ART UNIT 2681 — Semiconductors/Memory
CURRENT CPC
Communications: Electrical
340/566
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354960 Krich et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Air Force Office of Scientific Research (AFOSR)
Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E)
MIT Lincoln Laboratory (MITLL)
Federally Funded Research and Development Center (FFRDC)
Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S) Steven Ira Krich (Lexington, Massachusetts);  Cory J. Prust (Waukesha, Wisconsin);  Ian Weiner (Braintree, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Steven Ira Krich (Lexington, Massachusetts);  Cory J. Prust (Waukesha, Wisconsin);  Ian Weiner (Braintree, Massachusetts)
ABSTRACT Described is a method of modifying an antenna pattern for a phased array antenna having at least one failed antenna element. A number of proximate beamformers in a proximate angular region about a beamformer at an angle of interest are determined. Each of the proximate beamformers has a proximate beamformer weight vector. A corrected beamformer weight vector is determined for the angle of interest as a linear combination of the proximate beamformer weight vectors. Each element of the corrected beamformer weight vector that corresponds to one of the failed antenna elements has a value of zero. The method enables computation of low spatial sidelobe antenna patterns without requiring a recalibration of the antenna thereby enabling uninterrupted operation of systems that employ phased array antennas. The method can also be used to control taper loss or sidelobe level for phased array antennas that have no failed antenna elements.
FILED Thursday, March 24, 2011
APPL NO 13/070688
ART UNIT 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Communications: Directive radio wave systems and devices
342/379
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355120 Englert et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Christoph R. Englert (Springfield, Virginia);  David E. Siskind (Silver Spring, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S) Christoph R. Englert (Springfield, Virginia);  David E. Siskind (Silver Spring, Maryland)
ABSTRACT Obtaining global tropospheric vertical wind profiles by directly detecting atmospheric winds using space borne, airborne and/or ground station platforms is accomplished by a DASH interferometer in the back-end of a Doppler wind LIDAR. In the front-end of the Doppler wind LIDAR, a laser illuminates an atmosphere and a telescope collects backscattered laser light return signals from the laser illuminated atmosphere. The DASH interferometer processes return signals from the atmosphere, forming an interferogram and determines from the interferogram a Doppler shift of the return signals, which is equivalent to determining the line of sight wind speed of the Doppler wind LIDAR observation, by measuring the frequency shift caused by winds. From this determination, global and/or non-global atmospheric wind profile data are transmitted over a communications network in either real-time and/or non-real-time, to facilitate weather forecasting, weather modeling, weather avoidance navigation, atmospheric research, hurricane warnings, operations systems selections and deployment of operational assets.
FILED Tuesday, September 07, 2010
APPL NO 12/876755
ART UNIT 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Optics: Measuring and testing
356/28.500
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355295 Smallin
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Bryan J. Smallin (Panama City, Florida)
ASSIGNEE(S) The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S) Bryan J. Smallin (Panama City, Florida)
ABSTRACT An underwater sensing and communications node includes an underwater vehicle, target sensing capability mounted on a forward portion of the underwater vehicle, at least three passive acoustic sensors evenly distributed about a first circumferential region of the underwater vehicle, and at least three transceiving hydrophones evenly distributed about a second circumferential region of the underwater vehicle. A controller governs collection of sensed data and transmission of the sensed data into the underwater environment.
FILED Thursday, August 19, 2010
APPL NO 12/807377
ART UNIT 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Communications, electrical: Acoustic wave systems and devices
367/134
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355466 Kleider et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) John Kleider (Decatur, Georgia);  Anthony Smith (Salt Lake City, Utah)
ASSIGNEE(S) General Dynamics C4 Systems, Inc. (Scottsdale, Arizona)
INVENTOR(S) John Kleider (Decatur, Georgia);  Anthony Smith (Salt Lake City, Utah)
ABSTRACT A method and system are provided for reducing power amplifier induced distortion. Power amplifier induced distortion is iteratively estimated and cancelled. When the difference between the current estimated power amplifier distortion and the previous estimated power amplifier distortion is less than a convergence threshold, particular M-QAM constellation points that are still in error are determined A M-QAM constellation point correction routine is provided that can move the incorrectly estimated M-QAM constellation points that are in error towards their expected quadrants by generating updated M-QAM constellation points. The remaining estimated non-linear power amplifier induced distortion in the received signal can then be estimated and canceled.
FILED Friday, September 25, 2009
APPL NO 12/567505
ART UNIT 2611 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC
Pulse or digital communications
375/316
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355606 Englund et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Dirk Englund (Thousand Oaks, California);  Andrei Faraon (Menlo Park, California);  Jelena Vuckovic (Palo Alto, California);  Ilya Fushman (Palo Alto, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
INVENTOR(S) Dirk Englund (Thousand Oaks, California);  Andrei Faraon (Menlo Park, California);  Jelena Vuckovic (Palo Alto, California);  Ilya Fushman (Palo Alto, California)
ABSTRACT Electrical control of the emitter of a coupled quantum emitter-resonant cavity structure is provided. Electrodes are disposed near a semiconductor quantum dot coupled to a semiconductor optical cavity such that varying an applied bias at the electrodes alters an electric field at the quantum dot. Optical input and output ports are coupled to the cavity, and an optical response of the device relates light emitted from the output port to light provided to the input port. Altering the applied bias at the electrodes is capable of altering the optical response. Preferably, the closest electrode to the cavity is disposed between or away from angular lobes of the cavity mode, to reduce loss caused by the proximity of electrode to cavity. The present approach is applicable to both waveguide-coupled devices and non-waveguide devices.
FILED Thursday, November 12, 2009
APPL NO 12/590729
ART UNIT 2883 — Optics
CURRENT CPC
Optical waveguides
385/16
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355635 Liu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Ketao Liu (Cerritos, California);  Qinghong W. Wang (Torrance, California)
ASSIGNEE(S) The Boeing Company (Chicago, Illinois)
INVENTOR(S) Ketao Liu (Cerritos, California);  Qinghong W. Wang (Torrance, California)
ABSTRACT A method for pointing control of a laser communication terminal on a spacecraft may include measuring a line-of-sight (LOS) error of the laser communication terminal. The method may also include estimating a LOS error of the laser communication terminal based on measurements from a spacecraft gyro and a gimbal gyro onboard the spacecraft. The method may further include switching from a LOS error measurement feedback to a LOS error estimate feedback to control pointing of the laser communication terminal during a power fade condition.
FILED Tuesday, September 01, 2009
APPL NO 12/551787
ART UNIT 2637 — Optical Communications
CURRENT CPC
Optical communications
398/122
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08356151 Arimilli et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Ravi K. Arimilli (Austin, Texas);  Robert S. Blackmore (Poughkeepsie, New York);  Ronald N. Kalla (Round Rock, Texas);  Chulho Kim (Poughkeepsie, New York);  Balaram Sinharoy (Poughkeepsie, New York);  Hanhong Xue (Poughkeepsie, New York)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) Ravi K. Arimilli (Austin, Texas);  Robert S. Blackmore (Poughkeepsie, New York);  Ronald N. Kalla (Round Rock, Texas);  Chulho Kim (Poughkeepsie, New York);  Balaram Sinharoy (Poughkeepsie, New York);  Hanhong Xue (Poughkeepsie, New York)
ABSTRACT A method performed in a data processing system initiates an asynchronous memory move (AMM) operation, whereby a processor performs a move of data in virtual address space from a first effective address to a second effective address and forwards parameters of the AMM operation to asynchronous memory mover logic for completion of the physical movement of data from a first memory location to a second memory location. The processor executes a second operation, which checks a status of the completion of the data move and returns a notification indicating the status. The notification indicates a status, which includes one of: data move in progress; data move totally done; data move partially done; data move cannot be performed; and occurrence of a translation look-aside buffer invalidate entry (TLBIE) operation. The processor initiates one or more actions in response to the notification received.
FILED Friday, February 01, 2008
APPL NO 12/024504
ART UNIT 2186 — Computer Architecture and I/O
CURRENT CPC
Electrical computers and digital processing systems: Memory
711/165
VIEW PATENT @ USPTO:  Full Text   PDF 
US RE43928 Clouse et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Air Systems Command (NAVAIR)
APPLICANT(S) Brian Ellis Clouse (Saugus, Massachusetts);  David P. Dube (Saco, Maine)
ASSIGNEE(S) United Technologies Corporation (Hartford, Connecticut)
INVENTOR(S) Brian Ellis Clouse (Saugus, Massachusetts);  David P. Dube (Saco, Maine)
ABSTRACT An adapter to permit borescope access inside a gas turbine engine including a compressor stator having a plurality of compressor stator segments comprises a body portion defining a bore extending longitudinally therethrough from a first end to be disposed adjacent to outside surfaces of adjacent compressor stator segments to a second end to be disposed adjacent to inside surfaces of adjacent compressor stator segments. The bore permits a borescope to enter therethrough. The adapter further comprises an attachment portion for circumferentially coupling at least one compressor stator segment to an outer casing of the gas turbine engine.
FILED Wednesday, June 29, 2011
APPL NO 13/171708
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Rotary kinetic fluid motors or pumps
415/115
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Health and Human Services (HHS) 

US 08353942 Merrill
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Thomas Lad Merrill (Sewell, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Thomas Lad Merrill (Sewell, New Jersey)
ABSTRACT A catheter apparatus configured to provide a delivery system for standard intervention devices typically used during emergency angioplasty and to provide rapid localized cooling to organs at risk of ischemic and reperfusion injury. The catheter apparatus including a catheter shaft having an inner core defining at least two coolant flow lumens adjacent to a blood conveyance lumen. Each coolant flow lumen in thermal contact with the blood conveyance lumen and thermally insulated from each other and the exterior surfaces of the catheter shaft.
FILED Friday, July 22, 2011
APPL NO 13/188640
ART UNIT 3739 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC
Surgery: Light, thermal, and electrical application
67/105
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354093 Becker et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Research Service Award (NRSA)
National Science Foundation (NSF)
APPLICANT(S) Matthew L. Becker (Frederick, Maryland);  Huafeng Fang (St. Louis, Missouri);  Xiaoxu Li (New York, New York);  Dipanjan Pan (West Bengal, India);  Raffaella Rossin (St. Louis, Missouri);  Xiankai Sun (Coppell, Texas);  John-Stephen Taylor (St. Louis, Missouri);  Jeffrey L. Turner (St. Louis, Missouri);  Michael John Welch (Clayton, Missouri);  Karen L. Wooley (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Matthew L. Becker (Frederick, Maryland);  Huafeng Fang (St. Louis, Missouri);  Xiaoxu Li (New York, New York);  Dipanjan Pan (West Bengal, India);  Raffaella Rossin (St. Louis, Missouri);  Xiankai Sun (Coppell, Texas);  John-Stephen Taylor (St. Louis, Missouri);  Jeffrey L. Turner (St. Louis, Missouri);  Michael John Welch (Clayton, Missouri);  Karen L. Wooley (St. Louis, Missouri)
ABSTRACT A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2′-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
FILED Friday, October 14, 2005
APPL NO 11/250830
ART UNIT 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Drug, bio-affecting and body treating compositions
424/1.690
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354110 Santamaria et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Pedro Santamaria (Calgary, Canada);  Anna Moore (Dracut, Massachusetts)
ASSIGNEE(S) UTI Limited Partnership (Calgary, Alberta, Canada);  The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S) Pedro Santamaria (Calgary, Canada);  Anna Moore (Dracut, Massachusetts)
ABSTRACT The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases.
FILED Friday, March 07, 2008
APPL NO 12/044435
ART UNIT 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Drug, bio-affecting and body treating compositions
424/184.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354115 Tripp et al.
FUNDED BY
Department of Health and Human Services (HHS)
Centers for Disease Control and Prevention (CDC)
APPLICANT(S) Ralph A. Tripp (Decatur, Georgia);  Larry J. Anderson (Atlanta, Georgia);  Michael P. Brown (St. Georges, Australia)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Services, Centers for Disease Control and Prevention (Washington, District of Columbia)
INVENTOR(S) Ralph A. Tripp (Decatur, Georgia);  Larry J. Anderson (Atlanta, Georgia);  Michael P. Brown (St. Georges, Australia)
ABSTRACT The present invention provides methods and adjuvants for enhancing an immune response to RSV in a host, wherein the methods and adjuvants comprise a source of a CD40 binding protein. Preferably, the CD40 binding protein is CD40L and the source is a vector comprising a promoter operatively linked to a CD40L coding region. The enhanced immune response produced by the adjuvants and methods of the current invention includes both increased expression of Th1 cytokines and increased production of antibody.
FILED Friday, April 04, 2008
APPL NO 12/098236
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Drug, bio-affecting and body treating compositions
424/211.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354224 Croce et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Carlo M. Croce (Columbus, Ohio);  Ramiro Garzon (Columbus, Ohio);  George A. Calin (Pearland, Texas)
ASSIGNEE(S) The Ohio State University (Columbus, Ohio)
INVENTOR(S) Carlo M. Croce (Columbus, Ohio);  Ramiro Garzon (Columbus, Ohio);  George A. Calin (Pearland, Texas)
ABSTRACT The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer and myeloproliferative disorders. The invention also provides methods of identifying anti-cancer agents.
FILED Monday, June 27, 2011
APPL NO 13/169184
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/6
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354225 Benner et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Steven Albert Benner (Gainesville, Florida);  Albert Michael Sismour (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Steven Albert Benner (Gainesville, Florida);  Albert Michael Sismour (Gainesville, Florida)
ABSTRACT This invention relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, defined to be those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. Most specifically, this invention discloses and claims processes for amplifying nucleic acid analogs containing non-standard nucleobases using polymerase chain reactions, and enzymes that perform this amplification.
FILED Thursday, March 09, 2006
APPL NO 11/371497
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/6.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354227 Kolpashchikov
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
APPLICANT(S) Dmitry Kolpashchikov (New York, New York)
ASSIGNEE(S) Columbia University in the City of New York (New York City, New York)
INVENTOR(S) Dmitry Kolpashchikov (New York, New York)
ABSTRACT New binary deoxyribozyme or ribozyme probes and methods are described for nucleic acid analysis, which allows the detection of nucleic acids under mild physiologic conditions with extraordinary specificity and high sensitivity to single nucleotide mismatches without PCR amplification.
FILED Sunday, February 04, 2007
APPL NO 12/162605
ART UNIT 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/6.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354229 Croce
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Carlo M. Croce (Columbus, Ohio)
ASSIGNEE(S) The Ohio State University Research Foundation (Columbus, Ohio)
INVENTOR(S) Carlo M. Croce (Columbus, Ohio)
ABSTRACT The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents.
FILED Friday, October 07, 2011
APPL NO 13/269410
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/6.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354231 Kwong et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Gabriel A. Kwong (Alhambra, California);  Ryan C. Bailey (Urbana, Illinois);  Rong Fan (Pasadena, California);  James R. Heath (South Pasadena, California)
ASSIGNEE(S) Cal. Inst. Tech. (Pasadena, California)
INVENTOR(S) Gabriel A. Kwong (Alhambra, California);  Ryan C. Bailey (Urbana, Illinois);  Rong Fan (Pasadena, California);  James R. Heath (South Pasadena, California)
ABSTRACT Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.
FILED Monday, January 04, 2010
APPL NO 12/652000
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/6.120
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354236 Lee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Virginia M. Y. Lee (Philadelphia, Pennsylvania);  John Q. Trojanowski (Philadelphia, Pennsylvania)
ASSIGNEE(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S) Virginia M. Y. Lee (Philadelphia, Pennsylvania);  John Q. Trojanowski (Philadelphia, Pennsylvania)
ABSTRACT Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods for diagnosing a neurodegenerative disease in a subject, and methods for determining the efficacy of a drug against a neurodegenerative disease. Novel antibodies that bind to TDP-43 are also provided.
FILED Thursday, March 26, 2009
APPL NO 12/412015
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/7.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354240 Norris et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Steven J. Norris (Houston, Texas);  Jing-Ren Zhang (Delmar, New York);  John M. Hardham (Gales Ferry, Connecticut);  Jemlyn K. Howell (Houston, Texas);  Alan G. Barbour (Newport Beach, California);  George M. Weinstock (Houston, Texas)
ASSIGNEE(S) Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S) Steven J. Norris (Houston, Texas);  Jing-Ren Zhang (Delmar, New York);  John M. Hardham (Gales Ferry, Connecticut);  Jemlyn K. Howell (Houston, Texas);  Alan G. Barbour (Newport Beach, California);  George M. Weinstock (Houston, Texas)
ABSTRACT The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
FILED Monday, December 05, 2011
APPL NO 13/311259
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/7.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354246 Ebright et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Richard H. Ebright (North Brunswick, New Jersey);  Jayanta Mukhopadhyay (Edison, New Jersey);  Konstantin Severinov (Piscataway, New Jersey);  Ekaterina Semenova (Highland Park, New Jersey)
ASSIGNEE(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
INVENTOR(S) Richard H. Ebright (North Brunswick, New Jersey);  Jayanta Mukhopadhyay (Edison, New Jersey);  Konstantin Severinov (Piscataway, New Jersey);  Ekaterina Semenova (Highland Park, New Jersey)
ABSTRACT The invention provides a method of inhibiting a bacterial RNA polymerases. The invention has applications in control of bacterial RNA polymerase activity, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.
FILED Friday, December 18, 2009
APPL NO 12/642396
ART UNIT 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/29
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354247 Wang
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Lai-Xi Wang (Ellicott City, Maryland)
ASSIGNEE(S) University of Maryland, Baltimore (Baltimore, Maryland)
INVENTOR(S) Lai-Xi Wang (Ellicott City, Maryland)
ABSTRACT A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of a catalyst comprising endoglycosidase (ENGase), to transfer the oligosaccharide moiety to the acceptor and yield the homogeneous glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline. A related method of glycoprotein or glycopeptide remodeling with a predetermined natural N-glycan or a tailor-made oligosaccharide moiety, and a method of remodeling an antibody including a heterogeneous sugar chain, are also described. The disclosed methodology enables glycoprotein drugs to be modified for prolonged half-life in vivo, reduced immunogenicity, and enhanced in vivo activity, and for targeting and drug delivery.
FILED Tuesday, October 05, 2010
APPL NO 12/898284
ART UNIT 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/68.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354250 Okumoto et al.
FUNDED BY
Department of Energy (DOE)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non-Profit Organization (NPO)
Human Frontier Science Program (HFSP)
APPLICANT(S) Sakiko Okumoto (Washington, District of Columbia);  Loren L. Looger (Washington, District of Columbia);  Wolf B. Frommer (Washington, District of Columbia)
ASSIGNEE(S) Carnegie Institution of Washington (Washington, District of Columbia)
INVENTOR(S) Sakiko Okumoto (Washington, District of Columbia);  Loren L. Looger (Washington, District of Columbia);  Wolf B. Frommer (Washington, District of Columbia)
ABSTRACT Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding neurotransmitter. Such biosensors are useful for the detection of neurotransmitter concentrations in vivo and in culture.
FILED Friday, June 25, 2010
APPL NO 12/823796
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/69.700
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354336 Afzali-Ardakani et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) Ali Afzali-Ardakani (Ossining, New York);  Shafaat Ahmed (Yorktown Heights, New York);  Hariklia Deligianni (Tenafly, New Jersey);  Dario L. Goldfarb (Dobbs Ferry, New York);  Stefan Harrer (New York, New York);  Binquan Luan (Ossining, New York);  Glenn J. Martyna (Croton-on-Hudson, New York);  Hongbo Peng (Chappaqua, New York);  Stanislav Polonsky (Putnam Valley, New York);  Stephen Rossnagel (Pleasantville, New York);  Xiaoyan Shao (Yorktown Heights, New York);  Gustavo A. Stolovitzky (Riverdale, New York)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) Ali Afzali-Ardakani (Ossining, New York);  Shafaat Ahmed (Yorktown Heights, New York);  Hariklia Deligianni (Tenafly, New Jersey);  Dario L. Goldfarb (Dobbs Ferry, New York);  Stefan Harrer (New York, New York);  Binquan Luan (Ossining, New York);  Glenn J. Martyna (Croton-on-Hudson, New York);  Hongbo Peng (Chappaqua, New York);  Stanislav Polonsky (Putnam Valley, New York);  Stephen Rossnagel (Pleasantville, New York);  Xiaoyan Shao (Yorktown Heights, New York);  Gustavo A. Stolovitzky (Riverdale, New York)
ABSTRACT Accordingly, the present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A substrate which has a conductive layer disposed thereon is provided and the conductive layer has an oxide layer with an exposed surface. The exposed surface of the oxide layer contacts a solution of an organic surface active compound in an organic solvent to form a protective layer of the organic surface active compound over the oxide layer. The protective layer has a thickness of from about 0.5 nm to about 5 nm and ranges therebetween depending on a chemical structure of the surface active compound.
FILED Tuesday, June 22, 2010
APPL NO 12/820543
ART UNIT 2898 — Semiconductors/Memory
CURRENT CPC
Semiconductor device manufacturing: Process
438/606
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354378 Kuliopulos et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Athan Kuliopulos (Winchester, Massachusetts);  Lidija Covic (Somerville, Massachusetts)
ASSIGNEE(S) Tufts Medical Center, Inc. (Boston, Massachusetts)
INVENTOR(S) Athan Kuliopulos (Winchester, Massachusetts);  Lidija Covic (Somerville, Massachusetts)
ABSTRACT The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
FILED Friday, February 27, 2009
APPL NO 12/394715
ART UNIT 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/20.600
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354379 Rotundo
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Richard L. Rotundo (Miami, Florida)
ASSIGNEE(S) University of Miami (Miami, Florida)
INVENTOR(S) Richard L. Rotundo (Miami, Florida)
ABSTRACT The present invention provides novel chimeric peptides and novel methods for treating animals including humans by administering the novel chimeric peptides. In particular, the invention is useful for enhancing endogenous acetylcholinesterase expression in individuals exposed to organophosphate compounds, such as nerve gases and pesticides.
FILED Tuesday, August 14, 2007
APPL NO 12/514384
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/21.500
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354384 Slack et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) Frank J. Slack (Guilford, Connecticut);  Michelle M. Boehm (New Haven, Connecticut)
ASSIGNEE(S) Yale University (New Haven, Connecticut)
INVENTOR(S) Frank J. Slack (Guilford, Connecticut);  Michelle M. Boehm (New Haven, Connecticut)
ABSTRACT Methods and compositions for modulating aging genes or their targets for the treatment or prevention of senescence or symptoms thereof have been developed based on the discovery of naturally occurring inhibitory nucleic acids, in particular lin-4 miRNA, that downregulate genes involved in senescence, lifespan, or age-related disorders. Representative aging genes include, but are not limited to lin-4, lin-14, let-7, lin-28, egl-35 and lin-42. Methods for identifying modulators of aging genes and targets of aging genes are also provided. The disclosed compositions are useful as diagnostics. These can be used in assays to compare genes in normal individuals, with those who are aging well or who demonstrate early senescence, and with those who have age-related disorders such as Parkinson's and Alzheimer's. The genes can be used to study the pathways and mechanisms involved in aging and age-related disorders. These genes can be used as drug targets, or in drug design, to develop drugs that can inhibit one or more characteristics of senescence or age-related disorders. These compositions should be effective therapies for treating or slowing the effects of one or more symptoms or characteristics of age-related disorders resulting from activation or over-expression of aging genes. Compositions that alter the expression of particular aging genes affecting the insulin-like signal pathway are described. Suitable compositions described herein include, inhibitory nucleic acids and small molecules, in particular miRNA.
FILED Friday, June 23, 2006
APPL NO 11/426292
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/44
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354390 Bavari et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Sina Bavari (Frederick, Maryland);  Kelly Lyn Warfield (Adamstown, Maryland);  Pamela Tan (Kulmbach, Germany);  Anna Borodovsky (Cambridge, Massachusetts);  Tatiana Novobrantseva (Wellesley, Massachusetts);  Antonin de Fougerolles (Brookline, Massachusetts)
ASSIGNEE(S) Alnylam Pharmaceuticals, Inc. (Cambridge, Massachusetts);  The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S) Sina Bavari (Frederick, Maryland);  Kelly Lyn Warfield (Adamstown, Maryland);  Pamela Tan (Kulmbach, Germany);  Anna Borodovsky (Cambridge, Massachusetts);  Tatiana Novobrantseva (Wellesley, Massachusetts);  Antonin de Fougerolles (Brookline, Massachusetts)
ABSTRACT The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
FILED Monday, April 25, 2011
APPL NO 13/093681
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/44.A00
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354435 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S) Che-Hong Chen (Fremont, California);  Daria Mochly-Rosen (Menlo Park, California);  Wenjin Yang (Foster City, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
INVENTOR(S) Che-Hong Chen (Fremont, California);  Daria Mochly-Rosen (Menlo Park, California);  Wenjin Yang (Foster City, California)
ABSTRACT The present invention provides compounds that function as modulators of aldehyde dehydrogenase activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition.
FILED Thursday, September 03, 2009
APPL NO 12/553805
ART UNIT 1625 — Organic Chemistry
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/338
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354440 Halperin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) José A. Halperin (Brookline, Massachusetts);  Amarnath Natarajan (Texas City, Texas);  Bertal Huseyin Aktas (Newton, Massachusetts);  Yun-Hua Fan (San Antonio, Texas);  Han Chen (College Station, Texas)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) José A. Halperin (Brookline, Massachusetts);  Amarnath Natarajan (Texas City, Texas);  Bertal Huseyin Aktas (Newton, Massachusetts);  Yun-Hua Fan (San Antonio, Texas);  Han Chen (College Station, Texas)
ABSTRACT Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
FILED Thursday, September 15, 2011
APPL NO 13/233074
ART UNIT 1622 — Organic Chemistry
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/369
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354447 Markou et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) Athina Markou (Del Mar, California);  Paul Kenny (San Diego, California);  Neil Paterson (Encinitas, California);  Svetlana Semenova (Carlsbad, California)
ASSIGNEE(S) The Scripps Research Institute (La Jolla, California)
INVENTOR(S) Athina Markou (Del Mar, California);  Paul Kenny (San Diego, California);  Neil Paterson (Encinitas, California);  Svetlana Semenova (Carlsbad, California)
ABSTRACT Methods are provided for treating disorders associated with mGlu receptors by simultaneously inhibiting at least two mGluRs belonging to at least two different groups. In one embodiment, there are provided methods for treating a disorder associated with mGlu receptors 2, 3, and 5, including administering to a subject in need thereof an effective amount of at least one antagonist which modulates mGluR2, mGluR3, and mGluRS. The disorders treated by the method include, for example, nicotine addiction, cocaine addiction, and depression.
FILED Wednesday, September 10, 2003
APPL NO 10/527525
ART UNIT 1627 — Organic Chemistry
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/454
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354451 Moran et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S) Graham R. Moran (Whitefish Bay, Wisconsin);  Panqing He (Oak Creek, Wisconsin)
ASSIGNEE(S) The UWM Research Foundation, Inc. (Milwaukee, Wisconsin)
INVENTOR(S) Graham R. Moran (Whitefish Bay, Wisconsin);  Panqing He (Oak Creek, Wisconsin)
ABSTRACT Methods of inhibiting phagolysosomal fusion in patients infected with a microorganism involve the administration of a 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting compound, such as 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) to the patient. A HPPD-inhibiting compound administered in an amount effective to enhance phagolysosomal fusion in the macrophages or neutrophils of the patient reduces or treats the infection. Methods for treating bacterial infections by administering a HPPD-inhibiting compound and reducing the production of pyomelanin or melanin in microorganisms are disclosed.
FILED Tuesday, March 09, 2010
APPL NO 12/720381
ART UNIT 1627 — Organic Chemistry
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/612
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354501 Kaplan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) David L. Kaplan (Concord, Massachusetts);  Xianyan Wang (Acton, Massachusetts)
ASSIGNEE(S) Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S) David L. Kaplan (Concord, Massachusetts);  Xianyan Wang (Acton, Massachusetts)
ABSTRACT The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.
FILED Friday, July 28, 2006
APPL NO 11/997193
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
530/353
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354521 Li
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Dechun Li (Fenton, Missouri)
ASSIGNEE(S) Saint Louis University (Saint Louis, Missouri)
INVENTOR(S) Dechun Li (Fenton, Missouri)
ABSTRACT This invention relates generally to compositions and methods which utilization nuclear receptors for regulating adipogenesis in cells. Specifically, the invention is directed to compositions which regulate transcription factor PPARγ, and enhance or inhibit the transcription of genes responsible for directing cell differentiation towards a pathway of adipogenesis. More specifically, disclosed herein is a novel polypeptide coactivator of PPARγ, and fragments thereof, which possess coactivator or corepressor activity. Also related are nucleotide sequences which express these polypeptides. Also disclosed is an interfering RNA that may be used to inhibit adipogenesis.
FILED Monday, August 30, 2010
APPL NO 12/870991
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Organic compounds
536/24.500
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354556 Kavash et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Robert W. Kavash (Radnor, Pennsylvania);  Haizhong Tang (Radnor, Pennsylvania);  Carol Mulrooney (Radnor, Pennsylvania);  Dahui Liu (Radnor, Pennsylvania)
ASSIGNEE(S) PolyMedix, Inc. (Radnor, Pennsylvania)
INVENTOR(S) Robert W. Kavash (Radnor, Pennsylvania);  Haizhong Tang (Radnor, Pennsylvania);  Carol Mulrooney (Radnor, Pennsylvania);  Dahui Liu (Radnor, Pennsylvania)
ABSTRACT The present invention provides methods for preparing a polymeric compound of Formula I:
or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.
FILED Thursday, October 21, 2010
APPL NO 12/908977
ART UNIT 1621 — Organic Chemistry
CURRENT CPC
Organic compounds
564/153
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355548 Kovacs, Jr. et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Sandor J. Kovacs, Jr. (St. Louis, Missouri);  Leonid Shmuylovich (St. Louis, Missouri);  Charles Sangwoo Chung (Tucson, Arizona)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Sandor J. Kovacs, Jr. (St. Louis, Missouri);  Leonid Shmuylovich (St. Louis, Missouri);  Charles Sangwoo Chung (Tucson, Arizona)
ABSTRACT Methods and related apparatus and systems for determining a load-independent index of diastolic function in the heart are described.
FILED Friday, September 29, 2006
APPL NO 12/088805
ART UNIT 2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Image analysis
382/128
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355767 Hunter et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Research Resources (NCRR)
APPLICANT(S) Martin Hunter (Bradford, Massachusetts);  Annika Enejder (Göteborg, Sweden);  Thomas Scecina (Medfield, Massachusetts);  Michael Feld (Jamaica Plain, Massachusetts);  Wei-Chuan Shih (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Martin Hunter (Bradford, Massachusetts);  Annika Enejder (Göteborg, Sweden);  Thomas Scecina (Medfield, Massachusetts);  Michael Feld (Jamaica Plain, Massachusetts);  Wei-Chuan Shih (Cambridge, Massachusetts)
ABSTRACT The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.
FILED Thursday, April 27, 2006
APPL NO 11/412418
ART UNIT 3777 — Optical Communications
CURRENT CPC
Surgery
6/316
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355772 Wedeen
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Van J. Wedeen (Sommerville, Massachusetts)
ASSIGNEE(S) The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S) Van J. Wedeen (Sommerville, Massachusetts)
ABSTRACT A method for processing MRI data in which a reference direction and a first voxel are selected. A first transverse orientation vector associated with the first voxel is determined. This first transverse orientation vector is normal to the reference direction. On the basis of the first transverse orientation vector, a second voxel is selected. A second transverse orientation vector associated with the second voxel is also selected. This second transverse orientation vector is likewise normal to the reference direction. The method also includes determining whether a relationship between the first and second transverse orientation vectors is consistent with a track normal to the reference direction and extending between the first and second voxels.
FILED Friday, March 10, 2006
APPL NO 11/817613
ART UNIT 3768 — Optical Communications
CURRENT CPC
Surgery
6/410
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US 08355776 Milner
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
Advanced Technology Program (NIST-ATP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Thomas E. Milner (Austin, Texas)
ASSIGNEE(S) Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S) Thomas E. Milner (Austin, Texas)
ABSTRACT Provided herein are systems, methods, and compositions for the use of optical coherence tomography for detection of cells.
FILED Thursday, October 18, 2007
APPL NO 11/874519
ART UNIT 3777 — Optical Communications
CURRENT CPC
Surgery
6/476
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US 08355795 Greenberg et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) Robert J. Greenberg (Los Angeles, California);  Kelly H. McClure (Simi Valley, California);  Arup Roy (Valencia, California)
ASSIGNEE(S) Second Sight Medical Products, Inc. (Sylmar, California)
INVENTOR(S) Robert J. Greenberg (Los Angeles, California);  Kelly H. McClure (Simi Valley, California);  Arup Roy (Valencia, California)
ABSTRACT A visual prosthesis apparatus and a method for limiting power consumption in a visual prosthesis apparatus. The visual prosthesis apparatus comprises a camera for capturing a video image, a video processing unit associated with the camera, the video processing unit configured to convert the video image to stimulation patterns, and a retinal stimulation system configured to stop stimulating neural tissue in a subject's eye based on the stimulation patterns when an error is detected in a forward telemetry received from the video processing unit.
FILED Friday, June 24, 2011
APPL NO 13/168653
ART UNIT 3766 — Optical Communications
CURRENT CPC
Surgery: Light, thermal, and electrical application
67/60
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US 08355876 Prabhakarpandian et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Balabhaskar Prabhakarpandian (Madison, Alabama);  Kapil Pant (Madison, Alabama);  Shivshankar Sundaram (Tampa, Florida)
ASSIGNEE(S) CFD Research Corporation (Huntsville, Alabama)
INVENTOR(S) Balabhaskar Prabhakarpandian (Madison, Alabama);  Kapil Pant (Madison, Alabama);  Shivshankar Sundaram (Tampa, Florida)
ABSTRACT An apparatus and method for assaying a tumor drug delivery vehicle comprises a synthetic microvascular network of interconnected flow channels in fluid communication through a porous wall with a tissue space containing animal cells and means for quantifying drug delivery from the microvascular network to the animal cells.
FILED Monday, December 28, 2009
APPL NO 12/648296
ART UNIT 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Data processing: Measuring, calibrating, or testing
72/19
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Department of Energy (DOE) 

US 08353312 Petrenko
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Serhiy Fedorovich Petrenko (Kiev, Ukraine)
ASSIGNEE(S) U.S. Department of Energy (Washington, District of Columbia)
INVENTOR(S) Serhiy Fedorovich Petrenko (Kiev, Ukraine)
ABSTRACT A motorized valve has a housing having an inlet and an outlet to be connected to a pipeline, a saddle connected with the housing, a turn plug having a rod, the turn plug cooperating with the saddle, and a drive for turning the valve body and formed as a piezoelectric drive, the piezoelectric drive including a piezoelectric generator of radially directed standing acoustic waves, which is connected with the housing and is connectable with a pulse current source, and a rotor operatively connected with the piezoelectric generator and kinematically connected with the rod of the turn plug so as to turn the turn plug when the rotor is actuated by the piezoelectric generator.
FILED Wednesday, April 19, 2006
APPL NO 11/406335
ART UNIT 3753 — Fluid Handling and Dispensing
CURRENT CPC
Fluid handling
137/554
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US 08354011 Elangovan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
Idaho National Laboratory (INL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S) S. Elangovan (South Jordan, Utah);  Joseph J. Hartvigsen (Kaysville, Utah);  Feng Zhao (Salt Lake City, Utah)
ASSIGNEE(S) Ceramatec, Inc. (Salt Lake City, Utah)
INVENTOR(S) S. Elangovan (South Jordan, Utah);  Joseph J. Hartvigsen (Kaysville, Utah);  Feng Zhao (Salt Lake City, Utah)
ABSTRACT An electrolyzer cell is disclosed which includes a cathode to reduce an oxygen-containing molecule, such as H2O, CO2, or a combination thereof, to produce an oxygen ion and a fuel molecule, such as H2, CO, or a combination thereof. An electrolyte is coupled to the cathode to transport the oxygen ion to an anode. The anode is coupled to the electrolyte to receive the oxygen ion and produce oxygen gas therewith. In one embodiment, the anode may be fabricated to include an electron-conducting phase having a perovskite crystalline structure or structure similar thereto. This perovskite may have a chemical formula of substantially (Pr(1-x)Lax)(z-y)A′yBO(3-∂), wherein 0<x<1, 0≦y≦0.5, and 0.8≦z≦1.1. In another embodiment, the cathode includes an electron-conducting phase that contains nickel oxide intermixed with magnesium oxide.
FILED Friday, November 19, 2010
APPL NO 12/950120
ART UNIT 1759 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC
Chemistry: Electrical and wave energy
24/266
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US 08354046 Jia et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Security, LLC (LANS)
National Nuclear Security Administration (NNSA)
Los Alamos National Laboratory (LANL)
Federally Funded Research and Development Center (FFRDC)
Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S) Quanxi Jia (Los Alamos, New Mexico);  Anthony K. Burrell (Los Alamos, New Mexico);  Eve Bauer (Los Alamos, New Mexico);  Filip Ronning (Los Alamos, New Mexico);  Thomas Mark McCleskey (Los Alamos, New Mexico);  Guifu Zou (Los Alamos, New Mexico)
ASSIGNEE(S) Los Alamos National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S) Quanxi Jia (Los Alamos, New Mexico);  Anthony K. Burrell (Los Alamos, New Mexico);  Eve Bauer (Los Alamos, New Mexico);  Filip Ronning (Los Alamos, New Mexico);  Thomas Mark McCleskey (Los Alamos, New Mexico);  Guifu Zou (Los Alamos, New Mexico)
ABSTRACT Highly ordered Ge films are prepared directly on single crystal Si substrates by applying an aqueous coating solution having Ge-bound polymer onto the substrate and then heating in a hydrogen-containing atmosphere. A coating solution was prepared by mixing water, a germanium compound, ethylenediaminetetraacetic acid, and polyethyleneimine to form a first aqueous solution and then subjecting the first aqueous solution to ultrafiltration.
FILED Friday, September 11, 2009
APPL NO 12/558314
ART UNIT 1761 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Compositions
252/518.100
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US 08354085 Guelis
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) Artem V. Guelis (Naperville, Illinois)
ASSIGNEE(S) U.S. Department of Energy (Washington, District of Columbia)
INVENTOR(S) Artem V. Guelis (Naperville, Illinois)
ABSTRACT The process of the invention is the separation of minor actinides from lanthanides in a fluid mixture comprising, fission products, lanthanides, minor actinides, rare earth elements, nitric acid and water by addition of an organic chelating aid to the fluid; extracting the fluid with a solvent comprising a first extractant, a second extractant and an organic diluent to form an organic extractant stream and an aqueous raffinate. Scrubbing the organic stream with a dicarboxylic acid and a chelating agent to form a scrubber discharge. The scrubber discharge is stripped with a simple buffering agent and a second chelating agent in the pH range of 2.5 to 6.1 to produce actinide and lanthanide streams and spent organic diluents. The first extractant is selected from bis(2-ethylhexyl)hydrogen phosphate (HDEHP) and mono(2-ethylhexyl)2-ethylhexyl phosphonate (HEH(EHP)) and the second extractant is selected from N,N,N,N-tetra-2-ethylhexyl diglycol amide (TEHDGA) and N,N,N′,N′-tetraoctyl-3-oxapentanediamide (TODGA).
FILED Friday, March 16, 2012
APPL NO 13/422006
ART UNIT 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Chemistry of inorganic compounds
423/9
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US 08354250 Okumoto et al.
FUNDED BY
Department of Energy (DOE)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non-Profit Organization (NPO)
Human Frontier Science Program (HFSP)
APPLICANT(S) Sakiko Okumoto (Washington, District of Columbia);  Loren L. Looger (Washington, District of Columbia);  Wolf B. Frommer (Washington, District of Columbia)
ASSIGNEE(S) Carnegie Institution of Washington (Washington, District of Columbia)
INVENTOR(S) Sakiko Okumoto (Washington, District of Columbia);  Loren L. Looger (Washington, District of Columbia);  Wolf B. Frommer (Washington, District of Columbia)
ABSTRACT Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding neurotransmitter. Such biosensors are useful for the detection of neurotransmitter concentrations in vivo and in culture.
FILED Friday, June 25, 2010
APPL NO 12/823796
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/69.700
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354262 Novick et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Scott Novick (Palo Alto, California);  Oscar Alvizo (Fremont, California)
ASSIGNEE(S) Codexis, Inc. (Redwood City, California)
INVENTOR(S) Scott Novick (Palo Alto, California);  Oscar Alvizo (Fremont, California)
ABSTRACT The present disclosure relates to chemically modified carbonic anhydrase polypeptides and soluble compositions, homogenous liquid formulations comprising them. The chemically modified carbonic anhydrase polypeptides have improved properties relative to the same carbonic anhydrase polypeptide that is not chemically modified including the improved properties of increased activity and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides methods of preparing the chemically modified polypeptides and methods of using the chemically modified polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering.
FILED Thursday, June 30, 2011
APPL NO 13/174253
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/188
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US 08354290 Sumant et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) Anirudha V. Sumant (Argonne, Illinois);  Orlando H. Auciello (Lemont, Illinois);  Derrick C. Mancini (Argonne, Illinois)
ASSIGNEE(S) UChicago Argonne, LLC (Argonne, Illinois)
INVENTOR(S) Anirudha V. Sumant (Argonne, Illinois);  Orlando H. Auciello (Lemont, Illinois);  Derrick C. Mancini (Argonne, Illinois)
ABSTRACT An efficient deposition process is provided for fabricating reliable RF MEMS capacitive switches with multilayer ultrananocrystalline (UNCD) films for more rapid recovery, charging and discharging that is effective for more than a billion cycles of operation. Significantly, the deposition process is compatible for integration with CMOS electronics and thereby can provide monolithically integrated RF MEMS capacitive switches for use with CMOS electronic devices, such as for insertion into phase array antennas for radars and other RF communication systems.
FILED Tuesday, April 05, 2011
APPL NO 13/080255
ART UNIT 2897 — Semiconductors/Memory
CURRENT CPC
Semiconductor device manufacturing: Process
438/53
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US 08354499 Mayer-Cumblidge et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) M. Uljana Mayer-Cumblidge (Richland, Washington);  Haishi Cao (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) M. Uljana Mayer-Cumblidge (Richland, Washington);  Haishi Cao (Richland, Washington)
ABSTRACT A molecular probe comprises two arsenic atoms and at least one cyanine based moiety. A method of producing a molecular probe includes providing a molecule having a first formula, treating the molecule with HgOAc, and subsequently transmetallizing with AsCl3. The As is liganded to ethanedithiol to produce a probe having a second formula. A method of labeling a peptide includes providing a peptide comprising a tag sequence and contacting the peptide with a biarsenical molecular probe. A complex is formed comprising the tag sequence and the molecular probe. A method of studying a peptide includes providing a mixture containing a peptide comprising a peptide tag sequence, adding a biarsenical probe to the mixture, and monitoring the fluorescence of the mixture.
FILED Tuesday, May 04, 2010
APPL NO 12/773707
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
530/328
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US 08354514 Siezak et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Thomas R. Siezak (Livermore, California);  Shea Gardner (Oakland, California);  Clinton Torres (Pleasanton, California);  Elizabeth Vitalis (Livermore, California);  Raymond J. Lenhoff (Livermore, California)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S) Thomas R. Siezak (Livermore, California);  Shea Gardner (Oakland, California);  Clinton Torres (Pleasanton, California);  Elizabeth Vitalis (Livermore, California);  Raymond J. Lenhoff (Livermore, California)
ABSTRACT Described are kits and methods useful for detection of agricultural pathogens in a sample. Genomic sequence information from agricultural pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay and/or an array assay to successfully identify the presence or absence of pathogens in a sample.
FILED Friday, July 23, 2010
APPL NO 12/842952
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Organic compounds
536/23.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354517 Thompson et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
Idaho National Laboratory (INL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S) David N. Thompson (Idaho Falls, Idaho);  William A. Apel (Jackson, Wyoming);  Vicki S. Thompson (Idaho Falls, Idaho);  David W. Reed (Idaho Falls, Idaho);  Jeffrey A. Lacey (Idaho Falls, Idaho)
ASSIGNEE(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
INVENTOR(S) David N. Thompson (Idaho Falls, Idaho);  William A. Apel (Jackson, Wyoming);  Vicki S. Thompson (Idaho Falls, Idaho);  David W. Reed (Idaho Falls, Idaho);  Jeffrey A. Lacey (Idaho Falls, Idaho)
ABSTRACT Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.
FILED Tuesday, September 20, 2011
APPL NO 13/200164
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Organic compounds
536/23.700
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354565 Brown et al.
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
National Energy Technology Laboratory (NETL)
APPLICANT(S) Thomas D. Brown (Finleyville, Pennsylvania);  Charles E. Taylor (Pittsburgh, Pennsylvania);  Alfred J. Unione (Pittsburgh, Pennsylvania)
ASSIGNEE(S) U.S. Department of Energy (Washington, District of Columbia)
INVENTOR(S) Thomas D. Brown (Finleyville, Pennsylvania);  Charles E. Taylor (Pittsburgh, Pennsylvania);  Alfred J. Unione (Pittsburgh, Pennsylvania)
ABSTRACT The disclosure provides a method and apparatus for forming gas hydrates from a two-phase mixture of water and a hydrate forming gas. The two-phase mixture is created in a mixing zone which may be wholly included within the body of a spray nozzle. The two-phase mixture is subsequently sprayed into a reaction zone, where the reaction zone is under pressure and temperature conditions suitable for formation of the gas hydrate. The reaction zone pressure is less than the mixing zone pressure so that expansion of the hydrate-forming gas in the mixture provides a degree of cooling by the Joule-Thompson effect and provides more intimate mixing between the water and the hydrate-forming gas. The result of the process is the formation of gas hydrates continuously and with a greatly reduced induction time. An apparatus for conduct of the method is further provided.
FILED Monday, June 14, 2010
APPL NO 12/814660
ART UNIT 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Chemistry of hydrocarbon compounds
585/15
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US 08354650 Grosholz, Jr. et al.
FUNDED BY
Department of Energy (DOE)
Brookhaven Science Associates, LLC (BSA)
Office of Science (DOE-SC)
Brookhaven National Laboratory (BNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Brookhaven Science Associates, LLC (BSA) at Upton, NY
APPLICANT(S) Joseph Grosholz, Jr. (Natrona Heights, Pennsylvania);  Paul O'Connor (Bellport, New York);  Gianluigi Degeronimo (Syosset, New York)
ASSIGNEE(S) Endicott Interconnect Technologies, Inc. (Endicott, New York);  Brookhaven Science Associates, LLC (Washington, District of Columbia)
INVENTOR(S) Joseph Grosholz, Jr. (Natrona Heights, Pennsylvania);  Paul O'Connor (Bellport, New York);  Gianluigi Degeronimo (Syosset, New York)
ABSTRACT A radiation detection and counting system (2) includes a radiation detector element (5) for outputting a signal related to an energy of a radiation event received thereby and an amplifier (8) for amplifying the signal output by the detector element (5). A gain equalization circuit (10) adjusts the gain of the amplified output signal and a plurality of comparators (12) compare the gain adjusted amplified output signal to a like plurality of different valued threshold signals that are independently adjustable of each other A plurality of counters (20) is operative whereupon only the counter associated with the one comparator (12) that changes state in response to the peak of the gain adjusted amplified output signal exceeding the value of the trigger threshold signal thereof is incremented. A storage (24) stores the incremented value of each counter (20) accumulated over a sample time interval and data output logic circuit (26) transfers the stored accumulated counts out of the storage.
FILED Thursday, March 22, 2007
APPL NO 12/282607
ART UNIT 2884 — Optics
CURRENT CPC
Radiant energy
250/394
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354651 Bingham et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) Philip R. Bingham (Knoxville, Tennessee);  James Allen Mullens (Farragut, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Philip R. Bingham (Knoxville, Tennessee);  James Allen Mullens (Farragut, Tennessee)
ABSTRACT An imaging system and method of imaging are disclosed. The imaging system can include an external radiation source producing pairs of substantially simultaneous radiation emissions of a picturization emission and a verification emissions at an emission angle. The imaging system can also include a plurality of picturization sensors and at least one verification sensor for detecting the picturization and verification emissions, respectively. The imaging system also includes an object stage is arranged such that a picturization emission can pass through an object supported on said object stage before being detected by one of said plurality of picturization sensors. A coincidence system and a reconstruction system can also be included. The coincidence can receive information from the picturization and verification sensors and determine whether a detected picturization emission is direct radiation or scattered radiation. The reconstruction system can produce a multi-dimensional representation of an object imaged with the imaging system.
FILED Wednesday, June 30, 2010
APPL NO 12/827402
ART UNIT 2884 — Optics
CURRENT CPC
Radiant energy
250/394
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355453 Dallum et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Gregory E. Dallum (Livermore, California);  Garth C. Pratt (Discovery Bay, California);  Peter C. Haugen (Livermore, California);  Carlos E. Romero (Livermore, California)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S) Gregory E. Dallum (Livermore, California);  Garth C. Pratt (Discovery Bay, California);  Peter C. Haugen (Livermore, California);  Carlos E. Romero (Livermore, California)
ABSTRACT An ultra-wideband (UWB) dual impulse transmitter is made up of a trigger edge selection circuit actuated by a single trigger input pulse; a first step recovery diode (SRD) based pulser connected to the trigger edge selection circuit to generate a first impulse output; and a second step recovery diode (SRD) based pulser connected to the trigger edge selection circuit in parallel to the first pulser to generate a second impulse output having a selected delay from the first impulse output.
FILED Monday, December 14, 2009
APPL NO 12/637715
ART UNIT 2611 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC
Pulse or digital communications
375/259
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355481 Breach et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Michael R. Breach (Leland, North Carolina);  David J. Keck (Wilmington, North Carolina);  Gerald A. Deaver (Wilmington, North Carolina)
ASSIGNEE(S) GE-Hitachi Nuclear Energy Americas LLC (Wilmington, North Carolina)
INVENTOR(S) Michael R. Breach (Leland, North Carolina);  David J. Keck (Wilmington, North Carolina);  Gerald A. Deaver (Wilmington, North Carolina)
ABSTRACT Provided is a sliding support and a system using the sliding support unit. The sliding support unit may include a fulcrum capture configured to attach to a support flange, a fulcrum support configured to attach to the fulcrum capture, and a baseplate block configured to support the fulcrum support. The system using the sliding support unit may include a pressure vessel, a pedestal bracket, and a plurality of sliding support units.
FILED Friday, August 14, 2009
APPL NO 12/541493
ART UNIT 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Induced nuclear reactions: Processes, systems, and elements
376/461
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355818 Nielsen et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
Idaho National Laboratory (INL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S) Curtis W. Nielsen (Rexburg, Idaho);  David J. Bruemmer (Idaho Falls, Idaho);  Miles C. Walton (Idaho Falls, Idaho);  Robert S. Hartley (Idaho Falls, Idaho);  David I. Gertman (Idaho Falls, Idaho);  Robert A. Kinoshita (Idaho Falls, Idaho);  Jonathan Whetten (Denver, Colorado)
ASSIGNEE(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
INVENTOR(S) Curtis W. Nielsen (Rexburg, Idaho);  David J. Bruemmer (Idaho Falls, Idaho);  Miles C. Walton (Idaho Falls, Idaho);  Robert S. Hartley (Idaho Falls, Idaho);  David I. Gertman (Idaho Falls, Idaho);  Robert A. Kinoshita (Idaho Falls, Idaho);  Jonathan Whetten (Denver, Colorado)
ABSTRACT A robot includes a hazard sensor, a locomotor, and a system controller. The robot senses a hazard intensity at a location of the robot, moves to a new location in response to the hazard intensity, and autonomously repeats the sensing and moving to determine multiple hazard levels at multiple locations. The robot may also include a communicator to communicate the multiple hazard levels to a remote controller. The remote controller includes a communicator for sending user commands to the robot and receiving the hazard levels from the robot. A graphical user interface displays an environment map of the environment proximate the robot and a scale for indicating a hazard intensity. A hazard indicator corresponds to a robot position in the environment map and graphically indicates the hazard intensity at the robot position relative to the scale.
FILED Thursday, September 03, 2009
APPL NO 12/553794
ART UNIT 3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC
Data processing: Generic control systems or specific applications
7/258
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US 08355866 Smith et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Stephen F. Smith (Loudon, Tennessee);  James A. Moore (Powell, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Stephen F. Smith (Loudon, Tennessee);  James A. Moore (Powell, Tennessee)
ABSTRACT Methods and apparatus are described for a navigation system. A method includes providing a global positioning system fix having a plurality of tracking parameters; providing a theater positioning system fix; monitoring the plurality of tracking parameters for predetermined conditions; and, when the predetermined conditions are met, sending a notifying signal and switching to the theater positioning system fix as a primary fix. An apparatus includes a system controller; a global positioning system receiver coupled to the system controller; a radio frequency locating receiver coupled to the system controller; and an operator interface coupled to the system controller.
FILED Thursday, October 13, 2011
APPL NO 13/272973
ART UNIT 3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC
Data processing: Vehicles, navigation, and relative location
71/468
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US 08356122 Satterfield et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) David L. Satterfield (Tewksbury, Massachusetts);  James C. Sexton (Yorktown Heights, New York)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) David L. Satterfield (Tewksbury, Massachusetts);  James C. Sexton (Yorktown Heights, New York)
ABSTRACT A plurality of processing cores, are central storage unit having at least memory connected in a daisy chain manner, forming a daisy chain ring layout on an integrated chip. At least one of the plurality of processing cores places trace data on the daisy chain connection for transmitting the trace data to the central storage unit, and the central storage unit detects the trace data and stores the trace data in the memory co-located in with the central storage unit.
FILED Friday, January 08, 2010
APPL NO 12/684804
ART UNIT 2116 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC
Electrical computers and digital data processing systems: Input/output
710/18
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National Science Foundation (NSF) 

US 08354093 Becker et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Research Service Award (NRSA)
National Science Foundation (NSF)
APPLICANT(S) Matthew L. Becker (Frederick, Maryland);  Huafeng Fang (St. Louis, Missouri);  Xiaoxu Li (New York, New York);  Dipanjan Pan (West Bengal, India);  Raffaella Rossin (St. Louis, Missouri);  Xiankai Sun (Coppell, Texas);  John-Stephen Taylor (St. Louis, Missouri);  Jeffrey L. Turner (St. Louis, Missouri);  Michael John Welch (Clayton, Missouri);  Karen L. Wooley (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Matthew L. Becker (Frederick, Maryland);  Huafeng Fang (St. Louis, Missouri);  Xiaoxu Li (New York, New York);  Dipanjan Pan (West Bengal, India);  Raffaella Rossin (St. Louis, Missouri);  Xiankai Sun (Coppell, Texas);  John-Stephen Taylor (St. Louis, Missouri);  Jeffrey L. Turner (St. Louis, Missouri);  Michael John Welch (Clayton, Missouri);  Karen L. Wooley (St. Louis, Missouri)
ABSTRACT A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2′-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
FILED Friday, October 14, 2005
APPL NO 11/250830
ART UNIT 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Drug, bio-affecting and body treating compositions
424/1.690
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354227 Kolpashchikov
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
APPLICANT(S) Dmitry Kolpashchikov (New York, New York)
ASSIGNEE(S) Columbia University in the City of New York (New York City, New York)
INVENTOR(S) Dmitry Kolpashchikov (New York, New York)
ABSTRACT New binary deoxyribozyme or ribozyme probes and methods are described for nucleic acid analysis, which allows the detection of nucleic acids under mild physiologic conditions with extraordinary specificity and high sensitivity to single nucleotide mismatches without PCR amplification.
FILED Sunday, February 04, 2007
APPL NO 12/162605
ART UNIT 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/6.100
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US 08354291 Zhou et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) Chongwu Zhou (Arcadia, California);  Koungmin Ryu (Los Angeles, California);  Alexander Badmaev (Pasadena, California);  Chuan Wang (Los Angeles, California)
ASSIGNEE(S) University of Southern California (Los Angeles, California)
INVENTOR(S) Chongwu Zhou (Arcadia, California);  Koungmin Ryu (Los Angeles, California);  Alexander Badmaev (Pasadena, California);  Chuan Wang (Los Angeles, California)
ABSTRACT Techniques, apparatus and systems are described for wafer-scale processing of aligned nanotube devices and integrated circuits. In one aspect, a method can include growing aligned nanotubes on at least one of a wafer-scale quartz substrate or a wafer-scale sapphire substrate. The method can include transferring the grown aligned nanotubes onto a target substrate. Also, the method can include fabricating at least one device based on the transferred nanotubes.
FILED Tuesday, November 24, 2009
APPL NO 12/625543
ART UNIT 2829 — Semiconductors/Memory
CURRENT CPC
Semiconductor device manufacturing: Process
438/57
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US 08354384 Slack et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) Frank J. Slack (Guilford, Connecticut);  Michelle M. Boehm (New Haven, Connecticut)
ASSIGNEE(S) Yale University (New Haven, Connecticut)
INVENTOR(S) Frank J. Slack (Guilford, Connecticut);  Michelle M. Boehm (New Haven, Connecticut)
ABSTRACT Methods and compositions for modulating aging genes or their targets for the treatment or prevention of senescence or symptoms thereof have been developed based on the discovery of naturally occurring inhibitory nucleic acids, in particular lin-4 miRNA, that downregulate genes involved in senescence, lifespan, or age-related disorders. Representative aging genes include, but are not limited to lin-4, lin-14, let-7, lin-28, egl-35 and lin-42. Methods for identifying modulators of aging genes and targets of aging genes are also provided. The disclosed compositions are useful as diagnostics. These can be used in assays to compare genes in normal individuals, with those who are aging well or who demonstrate early senescence, and with those who have age-related disorders such as Parkinson's and Alzheimer's. The genes can be used to study the pathways and mechanisms involved in aging and age-related disorders. These genes can be used as drug targets, or in drug design, to develop drugs that can inhibit one or more characteristics of senescence or age-related disorders. These compositions should be effective therapies for treating or slowing the effects of one or more symptoms or characteristics of age-related disorders resulting from activation or over-expression of aging genes. Compositions that alter the expression of particular aging genes affecting the insulin-like signal pathway are described. Suitable compositions described herein include, inhibitory nucleic acids and small molecules, in particular miRNA.
FILED Friday, June 23, 2006
APPL NO 11/426292
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/44
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US 08354451 Moran et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S) Graham R. Moran (Whitefish Bay, Wisconsin);  Panqing He (Oak Creek, Wisconsin)
ASSIGNEE(S) The UWM Research Foundation, Inc. (Milwaukee, Wisconsin)
INVENTOR(S) Graham R. Moran (Whitefish Bay, Wisconsin);  Panqing He (Oak Creek, Wisconsin)
ABSTRACT Methods of inhibiting phagolysosomal fusion in patients infected with a microorganism involve the administration of a 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting compound, such as 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) to the patient. A HPPD-inhibiting compound administered in an amount effective to enhance phagolysosomal fusion in the macrophages or neutrophils of the patient reduces or treats the infection. Methods for treating bacterial infections by administering a HPPD-inhibiting compound and reducing the production of pyomelanin or melanin in microorganisms are disclosed.
FILED Tuesday, March 09, 2010
APPL NO 12/720381
ART UNIT 1627 — Organic Chemistry
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/612
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US 08354501 Kaplan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) David L. Kaplan (Concord, Massachusetts);  Xianyan Wang (Acton, Massachusetts)
ASSIGNEE(S) Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S) David L. Kaplan (Concord, Massachusetts);  Xianyan Wang (Acton, Massachusetts)
ABSTRACT The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.
FILED Friday, July 28, 2006
APPL NO 11/997193
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
530/353
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US 08354555 Stellacci et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Francesco Stellacci (Somerville, Massachusetts);  Benjamin Wunsch (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Francesco Stellacci (Somerville, Massachusetts);  Benjamin Wunsch (Cambridge, Massachusetts)
ABSTRACT This invention provides a method for increasing the activity of catalysts. The method requires the introduction of the catalyst into nano-structured surfaces. The catalysts are introduced as functional groups in molecules forming a monolayer on a surface. A mixed monolayer of catalyst and inert molecules generates ordered domains of molecules on the surface. The catalyst is confined in regions of 0.5 nm to 3 nm in size and is surrounded by an inert material. The presence of such ordered domains that commensurate in size with the reactants, enhance the performance of the catalyst and increase the rate of the reaction.
FILED Friday, May 22, 2009
APPL NO 12/470586
ART UNIT 1621 — Organic Chemistry
CURRENT CPC
Organic compounds
562/493
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US 08355136 Glazier et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Biology and Neuroscience (IBN)
APPLICANT(S) James A. Glazier (Bloomington, Indiana);  Dragos Amarie (Bloomington, Indiana)
ASSIGNEE(S) Indiana University Research and Technology Corporation (Indianapolis, Indiana)
INVENTOR(S) James A. Glazier (Bloomington, Indiana);  Dragos Amarie (Bloomington, Indiana)
ABSTRACT Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.
FILED Monday, June 13, 2011
APPL NO 13/158502
ART UNIT 2886 — Optics
CURRENT CPC
Optics: Measuring and testing
356/445
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US 08355893 Suresh et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Krishnan Suresh (Madison, Wisconsin);  Kavous Jorabchi (Madison, Wisconsin);  Josh Danczyk (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Krishnan Suresh (Madison, Wisconsin);  Kavous Jorabchi (Madison, Wisconsin);  Josh Danczyk (Madison, Wisconsin)
ABSTRACT A method and system for simulating and analyzing the behavior of a structural component of a computerized model in response to a simulated event to determine an optimized shape for the component is disclosed. The shape is optimized using an implicit dimensional reduction rather than an explicit geometric replacement by discarding data of a 3D discretization that has little or no bearing on the performance of the component to a simulated event. The reduced dataset is then collapsed onto a lower dimension projection that is applied over a force vector that is representative of the simulated event to determine the behavior of the component to the simulated event. Optimization tools may then be used to modify the physical attributes of the component and performance of the component once again simulated until an optimized component is determined.
FILED Friday, December 12, 2008
APPL NO 12/333743
ART UNIT 2123 — AI & Simulation/Modeling
CURRENT CPC
Data processing: Structural design, modeling, simulation, and emulation
73/1
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US 08355903 Birnbaum et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) Lawrence A. Birnbaum (Evanston, Illinois);  Kristian J. Hammond (Chicago, Illinois);  Nicholas D. Allen (Chicago, Illinois);  John R. Templon (Chicago, Illinois)
ASSIGNEE(S) Northwestern University (Evanston, Illinois)
INVENTOR(S) Lawrence A. Birnbaum (Evanston, Illinois);  Kristian J. Hammond (Chicago, Illinois);  Nicholas D. Allen (Chicago, Illinois);  John R. Templon (Chicago, Illinois)
ABSTRACT A system and method for automatically generating a narrative story receives data and information pertaining to a domain event. The received data and information and/or one or more derived features are then used to identify a plurality of angles for the narrative story. The plurality of angles is then filtered, for example through use of parameters that specify a focus for the narrative story, length of the narrative story, etc. Points associated with the filtered plurality of angles are then assembled and the narrative story is rendered using the filtered plurality of angles and the assembled points.
FILED Thursday, May 13, 2010
APPL NO 12/779683
ART UNIT 2657 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC
Data processing: Speech signal processing, linguistics, language translation, and audio compression/decompression
74/9
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National Aeronautics and Space Administration (NASA) 

US 08353209 Zimmerli
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Gregory A. Zimmerli (Brunswick, Ohio)
ASSIGNEE(S) United States of America as represented by the Administrator of National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S) Gregory A. Zimmerli (Brunswick, Ohio)
ABSTRACT A method for measuring the quantity of fluid in a tank may include the steps of selecting a match between a measured set of electromagnetic eigenfrequencies and a simulated plurality of sets of electromagnetic eigenfrequencies using a matching algorithm, wherein the match is one simulated set of electromagnetic eigenfrequencies from the simulated plurality of sets of electromagnetic eigenfrequencies, and determining the fill level of the tank based upon the match.
FILED Wednesday, September 30, 2009
APPL NO 12/570841
ART UNIT 2856 — Printing/Measuring and Testing
CURRENT CPC
Measuring and testing
073/290.B00
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354075 Tai et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
National Space Biomedical Research Institute (NSBRI)
APPLICANT(S) Yu-Chong Tai (Pasadena, California);  Siyang Zheng (Pasadena, California);  Harvey Kasdan (Sherman Oaks, California)
ASSIGNEE(S) California Institute of Technology (Pasadena, California);  IRIS International, Inc. (Chatsworth, California)
INVENTOR(S) Yu-Chong Tai (Pasadena, California);  Siyang Zheng (Pasadena, California);  Harvey Kasdan (Sherman Oaks, California)
ABSTRACT The present invention provides a streamline-based device and a method for using the device for continuous separation of particles including cells in biological fluids. The device includes a main microchannel and an array of side microchannels disposed on a substrate. The main microchannel has a plurality of stagnation points with a predetermined geometric design, for example, each of the stagnation points has a predetermined distance from the upstream edge of each of the side microchannels. The particles are separated and collected in the side microchannels.
FILED Thursday, April 20, 2006
APPL NO 11/408514
ART UNIT 1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing
422/503
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354952 Dean
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Bruce H. Dean (New Market, Maryland)
ASSIGNEE(S) The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S) Bruce H. Dean (New Market, Maryland)
ABSTRACT Disclosed herein are systems, methods, and non-transitory computer-readable storage media for radio phase retrieval. A system practicing the method gathers first data from radio waves associated with an object observed via a first aperture, gathers second data from radio waves associated with the object observed via an introduced second aperture associated with the first aperture, generates reduced noise data by incoherently subtracting the second data from the first data, and performs phase retrieval for the radio waves by modeling the reduced noise data using a single Fourier transform. The first and second apertures are at different positions, such as side by side. This approach can include determining a value Q which represents a ratio of wavelength times a focal ratio divided by pixel spacing. This information can be used to accurately measure and correct alignment errors or other optical system flaws in the apertures.
FILED Monday, July 19, 2010
APPL NO 12/839060
ART UNIT 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Communications: Directive radio wave systems and devices
342/52
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355136 Glazier et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Biology and Neuroscience (IBN)
APPLICANT(S) James A. Glazier (Bloomington, Indiana);  Dragos Amarie (Bloomington, Indiana)
ASSIGNEE(S) Indiana University Research and Technology Corporation (Indianapolis, Indiana)
INVENTOR(S) James A. Glazier (Bloomington, Indiana);  Dragos Amarie (Bloomington, Indiana)
ABSTRACT Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.
FILED Monday, June 13, 2011
APPL NO 13/158502
ART UNIT 2886 — Optics
CURRENT CPC
Optics: Measuring and testing
356/445
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355579 LeMoigne-Stewart et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Jacqueline J. LeMoigne-Stewart (Bowie, Maryland);  Giulia Troglio (Genoa, Italy);  Jon A. Benediktsson (Reykjavik, Iceland);  Sebastiano B. Serpico (Genoa, Italy);  Gabriele Moser (Varazze, Italy)
ASSIGNEE(S) The United states of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S) Jacqueline J. LeMoigne-Stewart (Bowie, Maryland);  Giulia Troglio (Genoa, Italy);  Jon A. Benediktsson (Reykjavik, Iceland);  Sebastiano B. Serpico (Genoa, Italy);  Gabriele Moser (Varazze, Italy)
ABSTRACT A method for the extraction of Lunar data and/or planetary features is provided. The feature extraction method can include one or more image processing techniques, including, but not limited to, a watershed segmentation and/or the generalized Hough Transform. According to some embodiments, the feature extraction method can include extracting features, such as, small rocks. According to some embodiments, small rocks can be extracted by applying a watershed segmentation algorithm to the Canny gradient. According to some embodiments, applying a watershed segmentation algorithm to the Canny gradient can allow regions that appear as close contours in the gradient to be segmented.
FILED Wednesday, May 19, 2010
APPL NO 12/783054
ART UNIT 2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Image analysis
382/190
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 08354040 Kenar
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) James A. Kenar (East Peoria, Illinois)
ASSIGNEE(S) The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S) James A. Kenar (East Peoria, Illinois)
ABSTRACT Phase change materials that include oleochemical carbonates absorb and release latent heat upon changing phases from solid to liquid (melting) or from liquid to solid (solidifying). The oleochemical carbonates are prepared from oleochemical alcohols derived from animal fats and vegetable oils or other bio-based substances. These oleochemical carbonates have melting temperatures with a relatively high heat of fusion and are non-corrosive. Oleochemical carbonates can be mixed together in various proportions to adjust melting/solidification temperature ranges as required by a particular application.
FILED Friday, May 14, 2010
APPL NO 12/780434
ART UNIT 1731 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Compositions
252/71
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08354371 Oppert et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) Brenda S. Oppert (Manhattan, Kansas);  Juan Luis Jurat-Fuentes (Knoxville, Tennessee);  Jeffrey A. Fabrick (Maricopa, Arizona);  Cristopher Oppert (Knoxville, Tennessee)
ASSIGNEE(S) The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia);  The University of Tennesse Research Foundation (Knoxville, Tennessee)
INVENTOR(S) Brenda S. Oppert (Manhattan, Kansas);  Juan Luis Jurat-Fuentes (Knoxville, Tennessee);  Jeffrey A. Fabrick (Maricopa, Arizona);  Cristopher Oppert (Knoxville, Tennessee)
ABSTRACT Disclosed is a novel cadherin peptide that enhances the toxicity of Cry proteins. A novel insecticide composition comprising an effective amount of cadherin peptide having SEQ. ID. NO:2 and an effective amount of Bacillus thuringiensis Cry protein wherein the cadherin peptide comprises a Cry3Aa toxin binding region from the full-length T. molitor cadherin and has synergistic characteristics of a binary toxin potentiating Cry3 and Cry1 toxins against coleopterans and lepidopteran species, respectively.
FILED Tuesday, November 18, 2008
APPL NO 12/272903
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Drug, bio-affecting and body treating compositions
514/1.100
VIEW PATENT @ USPTO:  Full Text   PDF 
US PP23327 Cummins et al.
FUNDED BY
Department of Agriculture (USDA)
Agricultural Research Service (ARS)
APPLICANT(S) James Cummins (Geneva, New York);  Herbert Sanders Aldwinckle (Geneva, New York);  Terence Lee Robinson (Geneva, New York);  Gennaro Fazio (Geneva, New York)
ASSIGNEE(S) Cornell University (Ithaca, New York);  The United States of America as Represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S) James Cummins (Geneva, New York);  Herbert Sanders Aldwinckle (Geneva, New York);  Terence Lee Robinson (Geneva, New York);  Gennaro Fazio (Geneva, New York)
ABSTRACT The present invention relates to a new and distinct variety of apple tree rootstock named ‘G.890.’ The ‘G.890’ apple tree rootstock is a dwarfing rootstock that is resistant to fire blight (Erwinia amylovora) and crown rot (Phytophthora cactorum). The ‘G.890’ rootstock is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees.
FILED Wednesday, February 09, 2011
APPL NO 12/931745
ART UNIT 1661 — Plants
CURRENT CPC
Plants
PLT/174
VIEW PATENT @ USPTO:  Full Text   PDF 

National Security Agency (NSA) 

US 08354737 Andry et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Security Agency (NSA)
APPLICANT(S) Paul S Andry (Yorktown Heights, New York);  John M Cotte (New Fairfield, Connecticut);  John Ulrich Knickerbocker (Monroe, New York);  Cornelia K Tsang (Mohegan Lake, New York)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) Paul S Andry (Yorktown Heights, New York);  John M Cotte (New Fairfield, Connecticut);  John Ulrich Knickerbocker (Monroe, New York);  Cornelia K Tsang (Mohegan Lake, New York)
ABSTRACT A semiconductor structure includes: at least one silicon surface wherein the surface can be a substrate, wafer or other device. The structure further includes at least one electronic circuit formed on each side of the at least one surface; and at least one conductive high aspect ratio through silicon via running through the at least one surface. Each through silicon via is fabricated from at least one etch step and includes: at least one thermal oxide dielectric for coating at least some of a sidewall of the through silicon via for a later etch stop in fabrication of the through silicon via.
FILED Monday, January 03, 2011
APPL NO 12/983552
ART UNIT 2892 — Semiconductors/Memory
CURRENT CPC
Active solid-state devices
257/621
VIEW PATENT @ USPTO:  Full Text   PDF 
US 08355501 Newhart
FUNDED BY
National Security Agency (NSA)
APPLICANT(S) Donald W. Newhart (Elkridge, Maryland)
ASSIGNEE(S) The United States of America as Represented by the Director, National Security Agency (Washington, District of Columbia)
INVENTOR(S) Donald W. Newhart (Elkridge, Maryland)
ABSTRACT A method of collision-free hashing of near-match by selecting bit positions d that differ between a first input and a second input, selecting a degree of a first polynomial for a cyclic code proportional to d, selecting a bit length i of the first input and the second input, selecting a bit length cv of a check value greater than or equal to d, setting n>=i+cv, generating the first polynomial that divides xn+1, factoring the first polynomial into a second and a third polynomials, receiving the first input, dividing the first input by the second polynomial, dividing the first input by the third polynomial, and identifying the results of the last two steps as a hash of the first input.
FILED Friday, February 03, 2012
APPL NO 13/385474
ART UNIT 2453 — Computer Networks
CURRENT CPC
Cryptography
380/28
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Commerce (DOC) 

US 08355776 Milner
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
Advanced Technology Program (NIST-ATP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Thomas E. Milner (Austin, Texas)
ASSIGNEE(S) Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S) Thomas E. Milner (Austin, Texas)
ABSTRACT Provided herein are systems, methods, and compositions for the use of optical coherence tomography for detection of cells.
FILED Thursday, October 18, 2007
APPL NO 11/874519
ART UNIT 3777 — Optical Communications
CURRENT CPC
Surgery
6/476
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Homeland Security (DHS) 

US 08354641 Lorkovic
FUNDED BY
Department of Homeland Security (DHS)
APPLICANT(S) Ivan M. Lorkovic (Santa Barbara, California)
ASSIGNEE(S) Alliant Techsystems Inc. (Arlington, Virginia)
INVENTOR(S) Ivan M. Lorkovic (Santa Barbara, California)
ABSTRACT A system for detecting radiation using an array of cells containing a metastable material together with sensing apparatus and display apparatus.
FILED Thursday, May 17, 2012
APPL NO 13/473773
ART UNIT 2884 — Optics
CURRENT CPC
Radiant energy
250/338.200
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 08353846 Henry et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) James A. Henry (Portland, Oregon);  Grayson Silaski (Portland, Oregon);  David Gray (Portland, Oregon);  Edward V. Porsov (Portland, Oregon);  Kimberly Owens (Portland, Oregon)
ASSIGNEE(S) Oregon Health and Science University (Portland, Oregon);  The United States of America as represented by The Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S) James A. Henry (Portland, Oregon);  Grayson Silaski (Portland, Oregon);  David Gray (Portland, Oregon);  Edward V. Porsov (Portland, Oregon);  Kimberly Owens (Portland, Oregon)
ABSTRACT Methods, articles of manufacture, and systems for evaluating tinnitus are disclosed herein. According to various embodiments, a tinnitus evaluation system may include a tinnitus evaluation module configured to perform one or more tinnitus evaluation tests. A tinnitus evaluation test may comprise generating a first single-frequency sound based at least in part on a sound of a patient's tinnitus, and generating a narrow-band sound centered at the frequency of the first single-frequency sound. Tests include a hearing threshold test, a loudness match test, a pitch match test, a bandwidth match test, a minimum masking level test, and a residual inhibition test.
FILED Tuesday, July 17, 2007
APPL NO 12/374274
ART UNIT 3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC
Surgery
6/559
VIEW PATENT @ USPTO:  Full Text   PDF 

Non-Profit Organization (NPO) 

US 08354250 Okumoto et al.
FUNDED BY
Department of Energy (DOE)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non-Profit Organization (NPO)
Human Frontier Science Program (HFSP)
APPLICANT(S) Sakiko Okumoto (Washington, District of Columbia);  Loren L. Looger (Washington, District of Columbia);  Wolf B. Frommer (Washington, District of Columbia)
ASSIGNEE(S) Carnegie Institution of Washington (Washington, District of Columbia)
INVENTOR(S) Sakiko Okumoto (Washington, District of Columbia);  Loren L. Looger (Washington, District of Columbia);  Wolf B. Frommer (Washington, District of Columbia)
ABSTRACT Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding neurotransmitter. Such biosensors are useful for the detection of neurotransmitter concentrations in vivo and in culture.
FILED Friday, June 25, 2010
APPL NO 12/823796
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Chemistry: Molecular biology and microbiology
435/69.700
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 08354556 Kavash et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Robert W. Kavash (Radnor, Pennsylvania);  Haizhong Tang (Radnor, Pennsylvania);  Carol Mulrooney (Radnor, Pennsylvania);  Dahui Liu (Radnor, Pennsylvania)
ASSIGNEE(S) PolyMedix, Inc. (Radnor, Pennsylvania)
INVENTOR(S) Robert W. Kavash (Radnor, Pennsylvania);  Haizhong Tang (Radnor, Pennsylvania);  Carol Mulrooney (Radnor, Pennsylvania);  Dahui Liu (Radnor, Pennsylvania)
ABSTRACT The present invention provides methods for preparing a polymeric compound of Formula I:
or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.
FILED Thursday, October 21, 2010
APPL NO 12/908977
ART UNIT 1621 — Organic Chemistry
CURRENT CPC
Organic compounds
564/153
VIEW PATENT @ USPTO:  Full Text   PDF 

United States Postal Service (USPS) 

US 08356187 Cook et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) Jon L. Cook (Alexandria, Virginia);  Christine Ray (Washington, District of Columbia);  Cathy M. Rogerson (Annandale, Virginia)
ASSIGNEE(S) United States Postal Service (Washington, District of Columbia)
INVENTOR(S) Jon L. Cook (Alexandria, Virginia);  Christine Ray (Washington, District of Columbia);  Cathy M. Rogerson (Annandale, Virginia)
ABSTRACT A secure electronic mailbox is provided to a customer having an electronic account. The electronic account links the secure electronic mailbox to a physical address of the customer. The customer can send and receive secure and non-secure messages via the secure electronic mailbox. The customer can also access electronic services such as electronic bill presentment and payment using the secure electronic mailbox.
FILED Wednesday, January 21, 2009
APPL NO 12/357187
ART UNIT 2495 — Cryptography and Security
CURRENT CPC
Electrical computers and digital processing systems: Support
713/193
VIEW PATENT @ USPTO:  Full Text   PDF 

Government Rights Acknowledged 

US 08355539 Tan et al.
FUNDED BY
APPLICANT(S) Yi Tan (Princeton, New Jersey);  Feng Han (Princeton, New Jersey);  Jayan Eledath (Princeton, New Jersey);  Rakesh Kumar (Princeton, New Jersey);  Faroog Abdel-kareem Ibrahim (Dearborn Heights, Michigan)
ASSIGNEE(S) SRI International (Menlo Park, California);  Visteon Global Technologies, Inc. (Van Buren Township, Michigan)
INVENTOR(S) Yi Tan (Princeton, New Jersey);  Feng Han (Princeton, New Jersey);  Jayan Eledath (Princeton, New Jersey);  Rakesh Kumar (Princeton, New Jersey);  Faroog Abdel-kareem Ibrahim (Dearborn Heights, Michigan)
ABSTRACT A method for determining whether a target vehicle in front of a host vehicle intends to change lanes using radar data and image data is disclosed, comprising the steps of processing the image data to detect the boundaries of the lane of the host vehicle; estimating a ground plane by determining a projected vanishing point of the detected lane boundaries; using a camera projection matrix to map the target vehicle from the radar data to image coordinates; and determining lane change intentions of the target vehicle based on a moving trajectory and an appearance change of the target vehicle. Determining lane change intentions based on a moving trajectory of the target vehicle is based on vehicle motion trajectory relative to the center of the lane such that the relative distance of the target vehicle from the center of the lane follows a predetermined trend. Determining lane change intentions based on an appearance change of the target vehicle is based on a template that tracks changes to the appearance of the rear part of the target vehicle due to rotation.
FILED Thursday, June 26, 2008
APPL NO 12/146897
ART UNIT 2624 — Selective Visual Display Systems
CURRENT CPC
Image analysis
382/104
VIEW PATENT @ USPTO:  Full Text   PDF 

How To Use This Page 

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, January 15, 2013.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
     National Institutes of Health (NIH)
         National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
     Defense Advanced Research Projects Agency (DARPA)
         Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

  • A61B 1/149 (20130101)
  • A61B 1/71 (20130101)
  • A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2013/fedinvent-patents-20130115.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

info@wayfinder.digital