FedInvent™ Patents
Patent Details for Tuesday, November 12, 2013
This page was updated on Monday, March 27, 2023 at 03:53 AM GMT
Department of Health and Human Services (HHS)
| US 08578889 | Chiodo |
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| FUNDED BY |
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| APPLICANT(S) | Chris D. Chiodo (Warren, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chris D. Chiodo (Warren, Michigan) |
| ABSTRACT | A laboratory specimen, such as a mouse or rat, can be accurately and repeatedly imaged in an imaging machine, such as an MRI machine, when securely positioned on a specimen support bed. The support bed includes contours and accessories for centering a specimen on the support bed. One or more bite bars coact with a head clamp to accurately fix a specimen's head in the same position time after time. |
| FILED | Thursday, October 11, 2012 |
| APPL NO | 13/649815 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Animal husbandry 119/420 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579117 | Loutherback et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kevin Loutherback (Princeton, New Jersey); James C. Sturm (Princeton, New Jersey); Robert Austin (Princeton, New Jersey); Keith Morton (Princeton, New Jersey); Jason Puchalla (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Kevin Loutherback (Princeton, New Jersey); James C. Sturm (Princeton, New Jersey); Robert Austin (Princeton, New Jersey); Keith Morton (Princeton, New Jersey); Jason Puchalla (Princeton, New Jersey) |
| ABSTRACT | The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ. |
| FILED | Friday, July 24, 2009 |
| APPL NO | 12/509175 |
| ART UNIT | 3653 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Classifying, separating, and assorting solids 29/210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579787 | Shapiro et al. |
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| FUNDED BY |
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| APPLICANT(S) | Benjamin Shapiro (Washington, District of Columbia); Michael R. Emmert-Buck (Easton, Maryland) |
| ASSIGNEE(S) | University of Maryland College Park (College Park, Maryland); The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health (Washington, District of Columbia) |
| INVENTOR(S) | Benjamin Shapiro (Washington, District of Columbia); Michael R. Emmert-Buck (Easton, Maryland) |
| ABSTRACT | Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents. |
| FILED | Tuesday, May 19, 2009 |
| APPL NO | 12/468746 |
| ART UNIT | 3735 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Surgery 6/12 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579839 | Ludlow et al. |
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| FUNDED BY |
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| APPLICANT(S) | Christy Ludlow (Bethesda, Maryland); Christopher Poletto (North Oaks, Minnesota); Ianessa Humbert (Silver Spring, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Christy Ludlow (Bethesda, Maryland); Christopher Poletto (North Oaks, Minnesota); Ianessa Humbert (Silver Spring, Maryland) |
| ABSTRACT | Methods, devices and systems for recovering motor control of an area in the body of a patient affected by a neurological disorder. A device vibrotactilely stimulates a substitute site for the affected area thereby recovering the motor control of the affected area. The stimulation provided by the device is volitionally controlled by the patient. |
| FILED | Friday, June 30, 2006 |
| APPL NO | 11/993094 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Surgery: Kinesitherapy 61/46 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579885 | Meng |
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| FUNDED BY |
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| APPLICANT(S) | Ellis Meng (Pasadena, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Ellis Meng (Pasadena, California) |
| ABSTRACT | An implantable fluid delivery system may include a fluid reservoir configured to hold a supply of fluid, dispense that fluid under the control of an actuator, and be implanted within the body of a living host. The actuator may include a bellows configured to expand in a direction when inflated. The bellows may have folds with surfaces which run substantially perpendicular to the direction of expansion in a collapsed state and which define a stacked set of convolutions. Each convolution may have a collapsed height of no more than 1 mm and a width perpendicular to the direction of expansion of no more than 8 mm. Electrodes may be configured to come in electrical contact with an electrolyte within the bellows and to cause electricity to run through the electrolyte, thereby causing the electrolyte to break down into a gas and, in turn, to cause the bellows to expand. |
| FILED | Friday, February 19, 2010 |
| APPL NO | 12/709335 |
| ART UNIT | 3763 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery 64/891.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580181 | Beachley et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vince Beachley (Mt. Pleasant, South Carolina); Xuejun Wen (Mt. Pleasant, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vince Beachley (Mt. Pleasant, South Carolina); Xuejun Wen (Mt. Pleasant, South Carolina) |
| ABSTRACT | Disclosed are methods of forming three dimensional arrays of aligned nanofibers in an open, loose structure of any desired depth. The arrays are formed according to an electrospinning process utilizing two parallel conducting plates to align the fibers and rotating tracks to distribute the fibers throughout the array. Arrays can be used as formed, for instance in tissue engineering applications as three dimensional scaffolding constructs. As-formed arrays can be combined with other materials to form a composite 3-D structure. For instance, composite polymeric materials can be electrospun to form composite nanofibers within the array. Multiple polymeric materials can be electrospun at different areas of the array to form a composite array including materially different nanofibers throughout the array. The arrays can be loaded with other fibrous or non-fibrous materials to form a composite array. Arrays can also be rolled to form a uniaxial fiber bundle. |
| FILED | Friday, October 01, 2010 |
| APPL NO | 12/896268 |
| ART UNIT | 1747 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Plastic and nonmetallic article shaping or treating: Processes 264/465 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580184 | Montoya |
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| FUNDED BY |
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| APPLICANT(S) | Jean Patrick Montoya (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jean Patrick Montoya (Ann Arbor, Michigan) |
| ABSTRACT | A method of forming hollow fiber bundles includes the step of providing a mat having a plurality of hollow fibers forming a weft and a plurality of soluble fibers forming a warp. Each hollow fiber extends between a first side and an opposed second side of the mat. The mat is bundled so as to form a bundle with the first side of the mat defining a first end of the bundle and the second side of the mat defining a second end of the bundle. At least a portion of the bundle is potted so as to substantially fix a position of the hollow fibers relative to each other. The soluble fibers are at least partially dissolved so as to remove the soluble fibers from the bundle. |
| FILED | Tuesday, June 21, 2011 |
| APPL NO | 13/165199 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Plastic and nonmetallic article shaping or treating: Processes 264/607 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580231 | Sukerkar et al. |
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| FUNDED BY |
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| APPLICANT(S) | Preeti A. Sukerkar (Glenview, Illinois); Jiyoun Lee (Palo Alto, California); Teresa K. Woodruff (Chicago, Illinois); Thomas J. Meade (Wilmette, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Preeti A. Sukerkar (Glenview, Illinois); Jiyoun Lee (Palo Alto, California); Teresa K. Woodruff (Chicago, Illinois); Thomas J. Meade (Wilmette, Illinois) |
| ABSTRACT | The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging. |
| FILED | Tuesday, July 17, 2012 |
| APPL NO | 13/551344 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/57 (20130101) A61K 49/106 (20130101) Original (OR) Class Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/00 (20130101) Steroids C07J 1/0003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580245 | Metzger et al. |
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| FUNDED BY |
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| APPLICANT(S) | Joseph M. Metzger (Ann Arbor, Michigan); Dewayne Townsend (Ann Arbor, Michigan); Soichiro Yasuda (Ann Arbor, Michigan); Daniel E. Michele (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Joseph M. Metzger (Ann Arbor, Michigan); Dewayne Townsend (Ann Arbor, Michigan); Soichiro Yasuda (Ann Arbor, Michigan); Daniel E. Michele (Ann Arbor, Michigan) |
| ABSTRACT | The present invention relates to compositions and methods for treating and preventing heart disease. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing heart disease (e.g., in subjects with muscular dystrophy) and for treating cells and tissue damage caused by ischemia and cell death (e.g., for treating dystrophin-deficient cells (e.g., myocytes)). |
| FILED | Friday, October 29, 2010 |
| APPL NO | 12/915352 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/78.380 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580249 | Blazar et al. |
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| FUNDED BY |
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| APPLICANT(S) | Bruce Blazar (Golden Valley, Minnesota); Jakub Tolar (Minneapolis, Minnesota); Catherine M. Verfaillie (Lauven, Belgium) |
| ASSIGNEE(S) | Regents of the University of Minnesota (St. Paul, Minnesota) |
| INVENTOR(S) | Bruce Blazar (Golden Valley, Minnesota); Jakub Tolar (Minneapolis, Minnesota); Catherine M. Verfaillie (Lauven, Belgium) |
| ABSTRACT | The present invention relates to methods for providing lysosomal enzymes to a subject by administering stem cells, preferably Multipotent Adult Progenitor Cells (MAPCs). The invention further relates to methods for treating lysosomal storage disorders by administering stem cells. |
| FILED | Tuesday, April 05, 2011 |
| APPL NO | 13/080109 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.700 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580253 | Rubin-Bejerano et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ifat Rubin-Bejerano (Belmont, Massachusetts); Gerald R. Fink (Chestnut Hill, Massachusetts); Claudia Abeijon (Worcester, Massachusetts); Danial S. Kohane (Newton, Massachusetts); Jason E. Fuller (Boston, Massachusetts); Robert S. Langer (Newton, Massachusetts) |
| ASSIGNEE(S) | Whitehead Institute (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Ifat Rubin-Bejerano (Belmont, Massachusetts); Gerald R. Fink (Chestnut Hill, Massachusetts); Claudia Abeijon (Worcester, Massachusetts); Danial S. Kohane (Newton, Massachusetts); Jason E. Fuller (Boston, Massachusetts); Robert S. Langer (Newton, Massachusetts) |
| ABSTRACT | This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety. |
| FILED | Tuesday, November 06, 2007 |
| APPL NO | 12/513830 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/130.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580263 | Adams et al. |
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| FUNDED BY |
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| APPLICANT(S) | Gregory P. Adams (Hatboro, Pennsylvania); Eva M. Horak (West Oragne, New Jersey); Louis M. Weiner (Washington, District of Columbia); James D. Marks (Kensington, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Gregory P. Adams (Hatboro, Pennsylvania); Eva M. Horak (West Oragne, New Jersey); Louis M. Weiner (Washington, District of Columbia); James D. Marks (Kensington, California) |
| ABSTRACT | Anti-EGFR family member antibodies and bispecific antibodies comprising one or more anti-EGFR family member antibodies are disclosed. These antibodies can be used to advantage to specifically target forms of cancer associated with the overexpression of members of the EGFR protein family. |
| FILED | Tuesday, November 20, 2007 |
| APPL NO | 12/515522 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/143.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580276 | Diamond et al. |
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| FUNDED BY |
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| APPLICANT(S) | Don Diamond (Glendora, California); Zhongde Wang (Mount Pleasant, South Carolina) |
| ASSIGNEE(S) | City of Hope (Duarte, California) |
| INVENTOR(S) | Don Diamond (Glendora, California); Zhongde Wang (Mount Pleasant, South Carolina) |
| ABSTRACT | A vaccine comprising an immunologically effective amount of recombinant modified vaccinia Ankara (rMVA) virus which is genetically stable after serial passage and produced by a) constructing a transfer plasmid vector comprising a modified H5 (mH5) promoter operably linked to a DNA sequence encoding a heterologous foreign protein antigen, wherein the expression of said DNA sequence is under the control of the mH5 promoter; b) generating rMVA virus by transfecting one or more plasmid vectors obtained from step a) into wild type MVA virus; c) identifying rMVA virus expressing one or more heterologous foreign protein antigens using one or more selection methods for serial passage; d) conducting serial passage; e) expanding an rMVA virus strain identified by step d); and f) purifying the rMVA viruses from step e) to form the vaccine. One embodiment is directed to a fusion cytomegalovirus (CMV) protein antigen comprising a nucleotide sequence encoding two or more antigenic portions of Immediate-Early Gene-1 or Immediate-Early Gene-2 (IEfusion), wherein the antigenic portions elicit an immune response when expressed by a vaccine. |
| FILED | Monday, June 07, 2010 |
| APPL NO | 12/795621 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/199.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580490 | Belisle et al. |
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| FUNDED BY |
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| APPLICANT(S) | John T. Belisle (Fort Collins, Colorado); Sebabrata Mahapatra (Fort Collins, Colorado) |
| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| INVENTOR(S) | John T. Belisle (Fort Collins, Colorado); Sebabrata Mahapatra (Fort Collins, Colorado) |
| ABSTRACT | A method for metabolomically evaluating a subject's response to an anti-mycobacterial agent. The method includes the steps of generating multiple small molecule profiles using samples collected from the subject at or immediately prior to the start of treatment and at a times subsequent to the start of treatment with the anti-mycobacterial agent, identifying predetermined biomarkers in the small molecule profiles of the subject and comparing to a known standard established for the agent as an indication of whether the human is benefiting from treatment with the agent. Also provided are methods of monitoring treatment compliance, methods for establishing biomarkers indicative of treatment efficacy and validated biomarkers shown to be effective in assessing efficacy of anti-tuberculosis drugs. |
| FILED | Monday, June 06, 2011 |
| APPL NO | 13/153824 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/4 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580492 | Ott et al. |
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| FUNDED BY |
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| APPLICANT(S) | Melanie Ott (Mill Valley, California); Sara Pagans Lista (San Francisco, California) |
| ASSIGNEE(S) | The J. David Gladstone Institutes (San Francisco, California) |
| INVENTOR(S) | Melanie Ott (Mill Valley, California); Sara Pagans Lista (San Francisco, California) |
| ABSTRACT | The present invention provides isolated methylated Tat peptides; and compositions comprising the peptides. The present invention further provides isolated antibodies specific for a Lys-51-methylated Tat polypeptide. Also provided are methods of identifying agents that inhibit Lys-51 methylation of a Tat polypeptide. The present invention further provides methods of treating an immunodeficiency virus infection in a mammalian subject. |
| FILED | Monday, September 12, 2011 |
| APPL NO | 13/230540 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/5 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580494 | Ginsberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | Stephen D. Ginsberg (Wynnewood, Pennsylvania); Shaoli Che (Stony Point, New York) |
| ASSIGNEE(S) | Research Foundation For Mental Hygiene, Inc. (Menands, New York) |
| INVENTOR(S) | Stephen D. Ginsberg (Wynnewood, Pennsylvania); Shaoli Che (Stony Point, New York) |
| ABSTRACT | A method and system for amplifying non-coding RNA, microRNA, and small polynucleotide sequences through the generation of a pool of signature sequences to the target sequences. The target sequences can be amplified through DNA synthesis, RNA synthesis, or the combination of DNA and RNA synthesis. The amplification of signature sequences provides an efficient and reproducible mechanism to determine the presence or absence of the miRNAs, to analyze the quantities of the target miRNAs, and for miRNA profiling. The method may also be used for screening for unknown non-coding RNAs, including novel miRNAs. |
| FILED | Friday, August 24, 2007 |
| APPL NO | 11/844695 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580500 | Croce et al. |
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| FUNDED BY |
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| APPLICANT(S) | Carlo M. Croce (Columbus, Ohio); George A. Calin (Pearland, Texas); Stefano Volinia (Ferrara, Italy) |
| ASSIGNEE(S) | The Ohio State University (Columbus, Ohio) |
| INVENTOR(S) | Carlo M. Croce (Columbus, Ohio); George A. Calin (Pearland, Texas); Stefano Volinia (Ferrara, Italy) |
| ABSTRACT | The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. |
| FILED | Tuesday, February 28, 2012 |
| APPL NO | 13/406618 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580504 | Fredriksson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Simon Fredriksson (Uppsala, Sweden); Ronald W. Davis (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Simon Fredriksson (Uppsala, Sweden); Ronald W. Davis (Stanford, California) |
| ABSTRACT | Methods and compositions for detecting an analyte in a sample are provided. In practicing the subject methods, a sample is combined with at least a pair of proximity probes that each include an analyte binding domain and a nucleic acid domain. The resultant mixture is then contacted with a pair of asymmetric nucleic acid connectors. Proximity dependent connector mediated interaction between the nucleic acid domains of the proximity probes is then detected to determine the presence of the analyte in the sample. Also provided are kits and systems for practicing the subject methods. |
| FILED | Monday, January 24, 2011 |
| APPL NO | 13/012715 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.120 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580509 | Tomlins et al. |
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| FUNDED BY |
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| APPLICANT(S) | Scott Tomlins (Ann Arbor, Michigan); Daniel Rhodes (Ann Arbor, Michigan); Arul Chinnaiyan (Ann Arbor, Michigan); Rohit Mehra (Ann Arbor, Michigan); Mark A. Rubin (New York, New York); Xiao-Wei Sun (New York, New York); Sven Perner (Ellwaugen, Germany); Charles Lee (Marlborough, Massachusetts); Francesca Demichelis (New York, New York) |
| ASSIGNEE(S) | The Regents of The University of Michigan (Ann Arbor, Michigan); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Scott Tomlins (Ann Arbor, Michigan); Daniel Rhodes (Ann Arbor, Michigan); Arul Chinnaiyan (Ann Arbor, Michigan); Rohit Mehra (Ann Arbor, Michigan); Mark A. Rubin (New York, New York); Xiao-Wei Sun (New York, New York); Sven Perner (Ellwaugen, Germany); Charles Lee (Marlborough, Massachusetts); Francesca Demichelis (New York, New York) |
| ABSTRACT | Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided. |
| FILED | Wednesday, May 30, 2012 |
| APPL NO | 13/483176 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.120 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580511 | Stoilov et al. |
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| FUNDED BY |
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| APPLICANT(S) | Peter G. Stoilov (Glendale, California); Douglas L. Black (Santa Monica, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Peter G. Stoilov (Glendale, California); Douglas L. Black (Santa Monica, California) |
| ABSTRACT | The present invention provides reporter constructs for in vivo or in vitro monitoring of alternative pre-mRNA splicing events. The reporter constructs described herein are also particularly useful for high-throughput screening of compounds that affect alternative pre-mRNA splicing. Kits comprising the reporter constructs of the present invention find utility in a wide range of applications including, for example, basic research, drug screening, and drug design. |
| FILED | Tuesday, June 19, 2007 |
| APPL NO | 12/305764 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.130 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580512 | Marcus et al. |
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| FUNDED BY |
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| APPLICANT(S) | Stevan Marcus (Tuscaloosa, Alabama); Galina Gulis (Brasilia, Brazil); P. Connor Johnson (Cullman, Alabama) |
| ASSIGNEE(S) | University of Alabama (Tuscaloosa, Alabama) |
| INVENTOR(S) | Stevan Marcus (Tuscaloosa, Alabama); Galina Gulis (Brasilia, Brazil); P. Connor Johnson (Cullman, Alabama) |
| ABSTRACT | The disclosure encompasses methods for the screening of small molecules or nucleic acids that may reverse the inhibition of growth of the unicellular yeast Schizosaccharomyces pombe by rotenone. The use of a yeast as the screening target allows for the high-throughput screening of small molecule and nucleic acid libraries for candidates that may then be screened in animal models as therapeutic agents for the treatment of neurodegenerative diseases. The plant-derived isoflavonoid, rotenone, while only moderately inhibitory to S. pombe cell growth on complex rich medium, is highly inhibitory to growth on synthetic minimal medium. S. pombe cells carrying a deletion in the gene pmk1 are hypersensitive to rotenone. S. pombe, therefore, provides a model for elucidating complex 1-independent targets of rotenone, and can serve as a screening tool for identifying compounds or oligonucleotides potentially able to reverse the effects of rotenone or Parkinson's disease in animal or human subjects. |
| FILED | Friday, November 20, 2009 |
| APPL NO | 13/063865 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.130 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580513 | Sempere et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lorenzo F. Sempere (Lebanon, New Hampshire); Murray Korc (Hanover, New Hampshire); Meir Preis (Hanover, New Hampshire) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Lorenzo F. Sempere (Lebanon, New Hampshire); Murray Korc (Hanover, New Hampshire); Meir Preis (Hanover, New Hampshire) |
| ABSTRACT | The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression and optionally the presence of a protein cancer cell marker in biological samples such as formalin-fixed paraffin-embedded specimens using in situ hybridization and optionally an immunohistochemical assay. |
| FILED | Wednesday, June 29, 2011 |
| APPL NO | 13/172047 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.140 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580517 | Gautam et al. |
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| FUNDED BY |
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| APPLICANT(S) | Narasimhan Gautam (St. Louis, Missouri); Inaki Azpiazu (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University in St. Louis (St. Louis, Missouri) |
| INVENTOR(S) | Narasimhan Gautam (St. Louis, Missouri); Inaki Azpiazu (St. Louis, Missouri) |
| ABSTRACT | G protein biosensors comprising mammalian G protein subunits fused to fluorescent proteins emitting a FRET signal expressed in living intact functional cells. The intensity of the FRET signal is strongly responsive to the activation state of the biosensors. The biosensors respond reproducibly to agonist and antagonist drug molecules specific for G protein coupled receptors. The biosensors have utility in identifying and classifying candidate therapeutic drugs as to their therapeutic value. |
| FILED | Wednesday, February 04, 2004 |
| APPL NO | 10/771897 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580519 | Burger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Angelika M. Burger (Baltimore, Maryland); Edward A. Sausville (Silver Spring, Maryland) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| INVENTOR(S) | Angelika M. Burger (Baltimore, Maryland); Edward A. Sausville (Silver Spring, Maryland) |
| ABSTRACT | The present invention concerns diagnosing and/or prognosticating cancer in an individual and/or determining response to a Hsp90-interacting therapy in an individual. In particular, the methods and compositions of the therapy relate to levels of Hsp90-α in plasma. Additional methods concern determining levels of Hsp90-associated molecules. |
| FILED | Monday, November 26, 2007 |
| APPL NO | 12/515770 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580527 | Zuker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Charles S. Zuker (San Diego, California); Jon E. Adler (Sherwood, Oregon); Mark Hoon (Kensington, Maryland); Nick Ryba (Bethesda, Maryland); Ken Mueller (San Diego, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Charles S. Zuker (San Diego, California); Jon E. Adler (Sherwood, Oregon); Mark Hoon (Kensington, Maryland); Nick Ryba (Bethesda, Maryland); Ken Mueller (San Diego, California) |
| ABSTRACT | The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors. |
| FILED | Tuesday, October 11, 2011 |
| APPL NO | 13/271106 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580534 | Miyagi |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Masaru Miyagi (Shaker Heights, Ohio) |
| ASSIGNEE(S) | The University of North Dakota (Grand Forks, North Dakota) |
| INVENTOR(S) | Masaru Miyagi (Shaker Heights, Ohio) |
| ABSTRACT | A method for comparative proteomics using a peptidase under enzymatic conditions that permits the optimal incorporation of two oxygen atoms into a digested peptide. The method employs a peptidase to incorporate two 18O atoms into a peptide set derived from a population of proteins at a conditioned state, which is compared to a second peptide set incorporated with a single 16O atom derived from a population of proteins at a second conditioned state. Upon combining the two peptide sets, the populations of proteins are analyzed for qualitative and quantitative differences based on the content of 18O atoms and 16O atoms in the digested peptides using mass spectrometry instrumentation. The method is advantageous to improve the efficiency and timeframe of peptidase catalyzed 18O labeling reactions which increased the accuracy and reliability of quantitative proteomic experiments. |
| FILED | Monday, July 02, 2007 |
| APPL NO | 11/824662 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/23 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580545 | Alferiev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ivan Alferiev (Clementon, New Jersey); Robert J. Levy (Merion Station, Pennsylvania); Ilia Fishbein (Jenkintown, Pennsylvania) |
| ASSIGNEE(S) | The Children's Hospital of Philadelphia (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Ivan Alferiev (Clementon, New Jersey); Robert J. Levy (Merion Station, Pennsylvania); Ilia Fishbein (Jenkintown, Pennsylvania) |
| ABSTRACT | A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided. |
| FILED | Tuesday, November 29, 2011 |
| APPL NO | 13/306459 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/174 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580561 | Chancellor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael B. Chancellor (Pittsburgh, Pennsylvania); Johnny Huard (Wexford, Pennsylvania); Christopher C. Capelli (Kenosha, Wisconsin); Zhuqing Qu (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh Of The Commonwealth System Of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Michael B. Chancellor (Pittsburgh, Pennsylvania); Johnny Huard (Wexford, Pennsylvania); Christopher C. Capelli (Kenosha, Wisconsin); Zhuqing Qu (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction. |
| FILED | Wednesday, April 12, 2006 |
| APPL NO | 11/403788 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/325 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580570 | Karger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Barry L. Karger (Newton, Massachusetts); Jian Zhang (Plainsboro, New Jersey) |
| ASSIGNEE(S) | Northeastern University (Boston, Massachusetts) |
| INVENTOR(S) | Barry L. Karger (Newton, Massachusetts); Jian Zhang (Plainsboro, New Jersey) |
| ABSTRACT | A polymer-based PLOT capillary column prepared by in situ copolymerization of a functional monomer, which usually contains the retentive chemistries, and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Also disclosed is a system comprising the polymer-based PLOT column coupled to a mass flow or concentration sensitive detector, for carrying out a chemical analysis method on samples separated by liquid chromatography using the column, and a process for using the system. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 μm. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power and high column-to-column reproducibility. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems are capable of detecting the component parts of complex proteomic samples down to the low attomole to sub-attomole level. |
| FILED | Friday, July 15, 2011 |
| APPL NO | 13/184075 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/161 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580732 | Newgard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Christopher B. Newgard (Durham, North Carolina); Samuel B. Stephens (Durham, North Carolina); Jonathan C. Schisler (Morrisville, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Christopher B. Newgard (Durham, North Carolina); Samuel B. Stephens (Durham, North Carolina); Jonathan C. Schisler (Morrisville, North Carolina) |
| ABSTRACT | Methods of modulating blood glucose levels treating hyperglycemia and related complications and conditions by administration of a VGF biomolecule to a patient in need of such treatment are provided. Methods of enhancing insulin secretion from islet beta cells in a mammal exhibiting reduced insulin secretion by administration of a therapeutically effective amount of a VGF biomolecule are also provided. |
| FILED | Wednesday, April 07, 2010 |
| APPL NO | 12/755907 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/6.900 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580748 | McCoy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sharon L. McCoy (Portland, Oregon); Steven H. Hefeneider (Portland, Oregon) |
| ASSIGNEE(S) | 13Therapeutics, Inc. (Portland, Oregon) |
| INVENTOR(S) | Sharon L. McCoy (Portland, Oregon); Steven H. Hefeneider (Portland, Oregon) |
| ABSTRACT | Peptides for the treatment of inflammation, and therapeutic uses and methods of using the same are disclosed. Peptides including a transducing sequence are effective for inhibiting cytokine activity and TNF-α secretion through interaction with toll-like receptor signaling pathways. Experiments are described illustrating the efficacy of the compounds in treating otitis media, noise-induced hearing loss, age-related hearing loss, and improvement of ordinary hearing. |
| FILED | Thursday, April 05, 2012 |
| APPL NO | 13/440591 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/21.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580754 | Fire et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Andrew Z. Fire (Washington, District of Columbia); Stephen A. Kostas (Washington, District of Columbia); Mary K. Montgomery (Washington, District of Columbia); Lisa Timmons (Washington, District of Columbia); SiQun Xu (Washington, District of Columbia); Hiroaki Tabara (Boston, Massachusetts); Samuel E. Driver (Boston, Massachusetts); Craig C. Mello (Boston, Massachusetts) |
| ASSIGNEE(S) | Carnegie Institution of Washington (Washington, District of Columbia); The University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Andrew Z. Fire (Washington, District of Columbia); Stephen A. Kostas (Washington, District of Columbia); Mary K. Montgomery (Washington, District of Columbia); Lisa Timmons (Washington, District of Columbia); SiQun Xu (Washington, District of Columbia); Hiroaki Tabara (Boston, Massachusetts); Samuel E. Driver (Boston, Massachusetts); Craig C. Mello (Boston, Massachusetts) |
| ABSTRACT | A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods. |
| FILED | Monday, October 01, 2007 |
| APPL NO | 11/905449 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/44.A00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580755 | Xing et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lianping Xing (Webster, New York); Brendan F. Boyce (Pittsford, New York); Edward M. Schwarz (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Lianping Xing (Webster, New York); Brendan F. Boyce (Pittsford, New York); Edward M. Schwarz (Rochester, New York) |
| ABSTRACT | The present invention is directed to methods of treating an inflammatory condition in a patient. This method includes providing a therapeutic agent that is a vascular endothelial growth factor receptor-3 (VEGFR-3) agonist or a nucleic acid molecule encoding a VEGFR-3 agonist. The present invention is further directed to pharmaceutical compositions and therapeutic systems for treating an inflammatory condition. |
| FILED | Thursday, February 19, 2009 |
| APPL NO | 12/389193 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/44.R00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580769 | Farese |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert V. Farese (St. Petersburg, Florida) |
| ASSIGNEE(S) | The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia); The Roskamp Institute (Sarasota, Florida) |
| INVENTOR(S) | Robert V. Farese (St. Petersburg, Florida) |
| ABSTRACT | Disclosed herein are methods for treating obesity, metabolic syndrome, diabetes, or a combination of these conditions. The methods include selecting a subject with obesity, metabolic syndrome, or diabetes and administering to the subject a therapeutically effective amount of a composition comprising a compound that specifically inhibits hepatic protein kinase C (PKC)-ι, thereby treating the obesity, metabolic syndrome, or diabetes in the subject. In some embodiments the compound that specifically inhibits hepatic PKC-ι includes a thio-gold compound (such as aurothiomalate, aurothioglucose, and auranofin) or a derivative thereof, or a pharmaceutically acceptable salt thereof. In other embodiments, the compound that specifically inhibits hepatic PKC-ι includes 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-[1R-(1α,2β,3β,4α)] (ICAPP) or a derivative thereof, or a pharmaceutically acceptable salt thereof. |
| FILED | Friday, March 09, 2012 |
| APPL NO | 13/417075 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/94 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580776 | Feinstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Douglas L. Feinstein (Chicago, Illinois); Maria Vittoria Simonini (New Haven, Connecticut); Sergey Kalinin (Chicago, Illinois); Paul E. Polak (Munster, Indiana) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Douglas L. Feinstein (Chicago, Illinois); Maria Vittoria Simonini (New Haven, Connecticut); Sergey Kalinin (Chicago, Illinois); Paul E. Polak (Munster, Indiana) |
| ABSTRACT | This invention provides agents, compositions, pharmaceutical compositions and methods for treating or slowing the progression of a neurodegenerating disease, such as Alzheimer's disease and a demyelinating disease. |
| FILED | Monday, October 18, 2010 |
| APPL NO | 12/906914 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/183 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580789 | Krueger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ronald R. Krueger (Cleveland, Ohio); William J. Dupps (Bay Village, Ohio); Stephen Trokel (New York, New York); Ivey Thornton (Cleveland, Ohio) |
| ASSIGNEE(S) | The Cleveland Clinic Foundation (Cleveland, Ohio); Stephen Trokel (New York, New York) |
| INVENTOR(S) | Ronald R. Krueger (Cleveland, Ohio); William J. Dupps (Bay Village, Ohio); Stephen Trokel (New York, New York); Ivey Thornton (Cleveland, Ohio) |
| ABSTRACT | Provided herein are methods of protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa (ONLC) complex in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and protecting all or a portion of the optic nerve fiber layer within the ONLC of the individual. In a particular embodiment, the invention is directed to methods of treating glaucoma in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and treating the glaucoma in the individual. In yet another embodiment, the invention is directed to methods of treating glaucomatous optic neuropathy in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and treating the glaucomatous optic neuropathy in the individual. The method can further comprise administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's lamina cribrosa (LC). |
| FILED | Wednesday, April 02, 2008 |
| APPL NO | 12/593720 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/251 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580827 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ching-Shih Chen (Upper Arlington, Ohio); Hao-Chieh Chiu (Columbus, Ohio); Samuel Kulp (Hilliard, Ohio); John S. Gunn (Powell, Ohio); Larry S. Schlesinger (Powell, Ohio) |
| ASSIGNEE(S) | The Ohio State University Research Foundation (Columbus, Ohio) |
| INVENTOR(S) | Ching-Shih Chen (Upper Arlington, Ohio); Hao-Chieh Chiu (Columbus, Ohio); Samuel Kulp (Hilliard, Ohio); John S. Gunn (Powell, Ohio); Larry S. Schlesinger (Powell, Ohio) |
| ABSTRACT | A series of celecoxib derivatives defined by Formula I: were prepared and evaluated for their ability to inhibit the gram-negative bacteria Francisella tularensis. Pharmaceutical compositions including celecoxib derivatives and their use in methods for treating or preventing infection by Francisella tularensis in a subject are described. |
| FILED | Wednesday, September 12, 2012 |
| APPL NO | 13/610967 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/359 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580834 | Zembower et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David E. Zembower (La Grange, Illinois); David A. Eiznhamer (Bloomingdale, Illinois) |
| ASSIGNEE(S) | Angion Biomedica Corp. (Garden City, New York) |
| INVENTOR(S) | David E. Zembower (La Grange, Illinois); David A. Eiznhamer (Bloomingdale, Illinois) |
| ABSTRACT | The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role. |
| FILED | Monday, August 13, 2007 |
| APPL NO | 11/891618 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/406 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580843 | Tjalkens et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ronald B. Tjalkens (Fort Collins, Colorado); Stephen Safe (College Station, Texas) |
| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado); The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Ronald B. Tjalkens (Fort Collins, Colorado); Stephen Safe (College Station, Texas) |
| ABSTRACT | Presented herein are diindolylmethane derivative compounds useful for the prevention and or treatment of neurological conditions, including neurological conditions related to neuroinflammation. One such neurological condition is Parkinson's disease. |
| FILED | Wednesday, October 07, 2009 |
| APPL NO | 12/575415 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/415 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580844 | Munn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David Munn (Augusta, Georgia); Andrew Mellor (Augusta, Georgia) |
| ASSIGNEE(S) | Georgia Regents Research Institute, Inc. (Augusta, Georgia) |
| INVENTOR(S) | David Munn (Augusta, Georgia); Andrew Mellor (Augusta, Georgia) |
| ABSTRACT | The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic agent. |
| FILED | Thursday, August 27, 2009 |
| APPL NO | 12/548657 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/419 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580852 | Dennis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Edward A. Dennis (La Jolla, California); George Kokotos (Athens, Greece); Violetta Constantinou-Kokotou (Athens, Greece) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Edward A. Dennis (La Jolla, California); George Kokotos (Athens, Greece); Violetta Constantinou-Kokotou (Athens, Greece) |
| ABSTRACT | The disclosure provides a series of 2-oxoamides based on dipeptides and pseudodipeptides, which were synthesized and their activities toward two human intracellular phospholipases A2 (GIVA CPLA 2 and GVIA 1PLA 2) and one human secretory phospholipase A2 (GV sPLA 2) were evaluated. Derivatives containing a free carboxyl group are selective GIVA cPLA 2 inhibitors. A derivative based on the ethyl ester of an ether pseudodipeptide is the first 2-oxoamide, which preferentially inhibits GVIA iPLA 2. The effect of 2-oxoamides on the generation of arachidonic acid from RAW 264.7 macrophages was also studied. It was found that selective GIVA cPLA 2 inhibitors preferentially inhibited cellular arachidonic acid release; in which one pseudodipeptide gave an IC50 value of 2 μM. |
| FILED | Monday, April 19, 2010 |
| APPL NO | 13/262618 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580857 | Au et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jessie L. -S. Au (Columbus, Ohio); M. Guillaume Wientjes (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessie L. -S. Au (Columbus, Ohio); M. Guillaume Wientjes (Columbus, Ohio) |
| ABSTRACT | A method for determining a therapeutically effective amount of suramin for administering to a patient, who is to receive a cytotoxic agent, which comprises the steps of determining the circulating suramin concentration in the patient; administering suramin, if required, to establish a low circulating concentration of suramin in the patient of below about 200 μM; and administering the chemotherapeutic agent to the patient when the low circulating concentration of suramin is present in the patient. Conveniently a nomogram can be constructed for use in clinical settings with the suramin. |
| FILED | Monday, February 21, 2011 |
| APPL NO | 13/031306 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/597 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580921 | Wagner |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carston R. Wagner (Saint Paul, Minnesota) |
| ASSIGNEE(S) | University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Carston R. Wagner (Saint Paul, Minnesota) |
| ABSTRACT | The invention provides protein nanorings. |
| FILED | Friday, July 13, 2012 |
| APPL NO | 13/548947 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/323 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580927 | Dimitrov |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dimiter S. Dimitrov (Frederick, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Dimiter S. Dimitrov (Frederick, Maryland) |
| ABSTRACT | Described herein are engineered antibody constant domain molecules, such as CH2 or CH3 domain molecules, comprising at least one mutation, or comprising at least one complementarity determining region (CDR), or a functional fragment thereof, engrafted in a loop region of the CH2 domain. The CH2 domain molecules described herein are small, stable, soluble, exhibit little to no toxicity and are capable of binding antigen. |
| FILED | Friday, January 30, 2009 |
| APPL NO | 12/864758 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/387.300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580934 | Dao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | My Lien Dao (St. Petersburg, Florida) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | My Lien Dao (St. Petersburg, Florida) |
| ABSTRACT | The subject invention provides silica-based material that has high affinity to chitin, chitin derivatives and chitin-containing microorganisms at an acidic pH. In an embodiment, the silica-based material surface comprises glass. Also provided are methods for preparing the subject silica-based chitin-binding material. In addition, the subject invention provides rapid, specific, sensitive, accurate and convenient methods for detection, isolation and purification of chitin, chitin derivatives and chitin-containing microorganisms. |
| FILED | Thursday, August 26, 2010 |
| APPL NO | 12/869581 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/412 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580937 | Spudich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John Lee Spudich (Houston, Texas); Elena G. Govorunova (Houston, Texas); Oleg A. Sineshchekov (Houston, Texas) |
| ASSIGNEE(S) | Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | John Lee Spudich (Houston, Texas); Elena G. Govorunova (Houston, Texas); Oleg A. Sineshchekov (Houston, Texas) |
| ABSTRACT | Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted channelrhodopsins can be cloned and expressed in mammalian systems and used in optogenetic applications and as therapeutic agents. Also provided are methods and compositions for use in red-shifting the absorbance maxima of channelrhodopsins in order to improve their utility for use in vivo. |
| FILED | Wednesday, March 14, 2012 |
| APPL NO | 13/420352 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Organic compounds 536/23.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580939 | Dubensky, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas W. Dubensky, Jr. (Seattle, Washington); Justin Skoble (Concord, California); Peter M. Lauer (Albany, California); David N. Cook (Lafayette, California) |
| ASSIGNEE(S) | Aduro Biotech (Berkeley, California) |
| INVENTOR(S) | Thomas W. Dubensky, Jr. (Seattle, Washington); Justin Skoble (Concord, California); Peter M. Lauer (Albany, California); David N. Cook (Lafayette, California) |
| ABSTRACT | The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes. |
| FILED | Monday, May 02, 2011 |
| APPL NO | 13/099280 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Organic compounds 536/23.700 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580941 | Lareyre et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jean-Jacques Lareyre (Rennes Cedex, France); Marie-Claire Orgebin-Crist (Nashville, Tennessee); Robert J. Matusik (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Jean-Jacques Lareyre (Rennes Cedex, France); Marie-Claire Orgebin-Crist (Nashville, Tennessee); Robert J. Matusik (Nashville, Tennessee) |
| ABSTRACT | Isolated nucleic acids comprising a lipocalin gene promoter region, isolated nucleic acids comprising a human lipocalin gene, isolated nucleic acids encoding a lipocalin polypeptide, isolated lipocalin polypeptides, and uses thereof. The disclosed lipocalin nucleic acids and polypeptides can be used to generate a mouse model of male infertility, for drug discovery screens, and for therapeutic treatment of fertility-related conditions. |
| FILED | Wednesday, August 08, 2007 |
| APPL NO | 11/890842 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/24.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580944 | Klinman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dennis M. Klinman (Potomac, Maryland); Rainald Zeuner (Kiel, Germany); Mayda Gursel (Rockville, Maryland); Ihsan Gursel (Rockville, Maryland); Daniela Verthelyi (Potomac, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Dennis M. Klinman (Potomac, Maryland); Rainald Zeuner (Kiel, Germany); Mayda Gursel (Rockville, Maryland); Ihsan Gursel (Rockville, Maryland); Daniela Verthelyi (Potomac, Maryland) |
| ABSTRACT | The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. |
| FILED | Thursday, June 21, 2012 |
| APPL NO | 13/530028 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Organic compounds 536/24.300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580969 | Myers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Andrew G. Myers (Boston, Massachusetts); Jason D. Brubaker (Cheshire, Connecticut) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Andrew G. Myers (Boston, Massachusetts); Jason D. Brubaker (Cheshire, Connecticut) |
| ABSTRACT | The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides a more efficient route for preparing the enone intermediate. |
| FILED | Friday, September 14, 2012 |
| APPL NO | 13/616667 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Organic compounds 548/243 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580970 | Sharpless et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | K. Barry Sharpless (La Jolla, California); Valery Fokin (Oceanside, California); Vsevold V. Rostovtsev (Wilmington, Delaware); Luke Green (Basel, Switzerland); Fahmi Himo (Solna, Sweden) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | K. Barry Sharpless (La Jolla, California); Valery Fokin (Oceanside, California); Vsevold V. Rostovtsev (Wilmington, Delaware); Luke Green (Basel, Switzerland); Fahmi Himo (Solna, Sweden) |
| ABSTRACT | A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine. |
| FILED | Monday, March 05, 2012 |
| APPL NO | 13/412270 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Organic compounds 548/255 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580975 | Ghosh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arun K Ghosh (West Lafeyette, Indiana); Xiaoming Xu (Dallas, Texas) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Arun K Ghosh (West Lafeyette, Indiana); Xiaoming Xu (Dallas, Texas) |
| ABSTRACT | Herein are described a process for forming a quaternary carbon useful in the preparation of macrolactones, an enantioselective synthesis of (+)-peloruside A, and methods for treating a patient in need of relief from cancer or a cancer-related disease. The described processes are useful for preparing compounds containing quaternary carbons, including structural analogs and derivatives of peloruside A. |
| FILED | Friday, January 09, 2009 |
| APPL NO | 12/812067 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Organic compounds 549/23 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580977 | Shen |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ben Shen (Verona, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Ben Shen (Verona, Wisconsin) |
| ABSTRACT | The present invention relates to the biosynthetic gene cluster for tautomycetin (TTN) produces tautomycetin. Also provided are engineered micro-organisms for the production of TTN and analogs thereof, as well as methods of screening for compounds for activity. |
| FILED | Thursday, May 05, 2011 |
| APPL NO | 13/101624 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Organic compounds 549/323 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580990 | Bertrand et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Guy Bertrand (Riverside, California); Vincent Lavallo (Riverside, California); Guido D. Frey (Riverside, California); Bruno Donnadieu (Riverside, California); Michele Soleilhavoup (Riverside, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Guy Bertrand (Riverside, California); Vincent Lavallo (Riverside, California); Guido D. Frey (Riverside, California); Bruno Donnadieu (Riverside, California); Michele Soleilhavoup (Riverside, California) |
| ABSTRACT | Methods are provided for the catalytic hydroamination of compounds having an alkyne or allene functional group, in which the compound is contacted with ammonia or an amine in the presence of a catalytic amount of a gold complex under conditions sufficient for hydroamination to occur. |
| FILED | Friday, May 08, 2009 |
| APPL NO | 12/991588 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Organic compounds 556/110 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581045 | Farrand et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stephen K. Farrand (Seymour, Illinois); David Michael Barnhart (Champaign, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Stephen K. Farrand (Seymour, Illinois); David Michael Barnhart (Champaign, Illinois) |
| ABSTRACT | This disclosure relates to a mutant Agrobacterium tumefaciens that is functionally deleted for the atu1060 gene that codes for the cyclic di-GMP synthase Atu1060, as well as methods for its use in transforming plants with desired transgenes. Such bacteria are more virulent than currently used strains of A. tumefaciens, and thus can be used to transform a wider variety of plants, such as plants that are traditionally recalcitrant to such transformation. |
| FILED | Friday, November 19, 2010 |
| APPL NO | 12/950833 |
| ART UNIT | 1638 — Organic Chemistry |
| CURRENT CPC | Multicellular living organisms and unmodified parts thereof and related processes 8/294 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581584 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mukesh Sharma (Tallahassee, Florida); Myunggi Yi (Busan, South Korea); Hao Dong (Tallahassee, Florida); Huajun Qin (Tallahassee, Florida); David D. Busath (Orem, Utah); Huan-Xiang Zhou (Tallahassee, Florida); Timothy A. Cross (Tallahassee, Florida) |
| ASSIGNEE(S) | Florida State University Research Foundation (Tallahassee, Florida) |
| INVENTOR(S) | Mukesh Sharma (Tallahassee, Florida); Myunggi Yi (Busan, South Korea); Hao Dong (Tallahassee, Florida); Huajun Qin (Tallahassee, Florida); David D. Busath (Orem, Utah); Huan-Xiang Zhou (Tallahassee, Florida); Timothy A. Cross (Tallahassee, Florida) |
| ABSTRACT | The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance. |
| FILED | Thursday, May 26, 2011 |
| APPL NO | 13/067351 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/309 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581589 | Wald et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence L. Wald (Cambridge, Massachusetts); Vijayanand Alagappan (Streetsboro, Ohio); Jonathan R. Polimeni (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Lawrence L. Wald (Cambridge, Massachusetts); Vijayanand Alagappan (Streetsboro, Ohio); Jonathan R. Polimeni (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides a system and method for using a hardware-based compression of signals acquired with an magnetic resonance imaging (MRI) system. This allows a first multi-channel MR signal to be compressed to a second multi-channel MR signal having fewer channels than the first MR signal. This system and method reduces the number of RF receivers needed to achieve the sensitivity encoding benefits associated with highly parallel detection in MRI. Furthermore, the system and method reduces bottlenecks connection an MRI system's RF receiver and reconstruction computer and reduces the computational burden of image reconstruction. |
| FILED | Tuesday, February 02, 2010 |
| APPL NO | 12/698864 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/322 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582096 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zhongping Chen (Irvine, California); Gangjun Liu (Irvine, California); Mihael Balu (Newport Beach, California); Bruce Tromberg (Irvine, California); Eric Olaf Potma (Irvine, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zhongping Chen (Irvine, California); Gangjun Liu (Irvine, California); Mihael Balu (Newport Beach, California); Bruce Tromberg (Irvine, California); Eric Olaf Potma (Irvine, California) |
| ABSTRACT | A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging. |
| FILED | Wednesday, December 15, 2010 |
| APPL NO | 12/969295 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/301 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582098 | Tsupryk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Andriy Tsupryk (Coram, New York); Ivan Tovkach (Centereach, New York); Dmitriy Gavrilov (Setauket, New York); Vera Gorfinkel (Brook, New York); Boris Gorbovitski (Stony Brook, New York); Dmytro Gudkov (Stony Brook, New York); Tetyana Gudkova (Coram, New York) |
| ASSIGNEE(S) | The Research Foundation of State University of New York (Albany, New York) |
| INVENTOR(S) | Andriy Tsupryk (Coram, New York); Ivan Tovkach (Centereach, New York); Dmitriy Gavrilov (Setauket, New York); Georgiy Gudkov (Coram, New York); Vera Gorfinkel (Brook, New York); Boris Gorbovitski (Stony Brook, New York); Dmytro Gudkov (Stony Brook, New York) |
| ABSTRACT | A fiberized single photon sensitive spectrometer based on a 32-channel PMT sensor is highly sensitive with broad detection dynamic range. The spectrometer enables accurate and high speed detection, identification and analysis of biological samples labeled with multiple fluorescent markers, such as compositions of multi-color fluorescence signals or radiation emitted by multiple fluorescence dyes. A fiberized optical input of the spectrometer allows an easy and efficient coupling to any measurement system based on fiber collection of the analyzed fluorescence. The spectrometer provides highly accurate DNA sequencing. A 32 channel PMT single photon detector has a detection dynamic range of more than 20 bits and has a frame rate of about 3300 frames per second. The dynamic range of the detector's pixels reaches 108 photocounts per second. |
| FILED | Friday, October 24, 2008 |
| APPL NO | 12/734365 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/317 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583238 | Heldman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Great Lakes NeuroTechnologies Inc. (Valley View, Ohio) |
| ASSIGNEE(S) | Great Lakes Neuro Technologies Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Dustin A. Heldman (Shaker Heights, Ohio); Joseph P. Giuffrida (Hinckley, Ohio) |
| ABSTRACT | The present invention relates to a system and methods for noninvasively providing therapy for movement disorder symptoms. The present invention provides such a therapy system which provides trans-cranial direct current stimulation (tDCS) in order to treat those symptoms and the disorders. The present invention further provides such tDCS therapy while the subject sleeps in order to minimize the time required and impact of the therapy on the subject's waking life. The system, methods, and devices of the present invention are intended to provide a low-dose electrical current, trans-cranially, to a specific area of the subject's brain while he or she sleeps in order to decrease the occurrence, severity, and duration of the symptoms of movement disorders. The present invention aims to reduce the amount of medication necessary, counteract the effects of medication wearing off during sleep, and to overall improve the quality of life of subjects suffering from movement disorders. |
| FILED | Tuesday, October 02, 2012 |
| APPL NO | 13/633358 |
| ART UNIT | 3762 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery: Light, thermal, and electrical application 67/45 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583241 | Greenberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert J. Greenberg (Los Angeles, California); Arup Roy (Valencia, California); Avraham I. Caspi (La Jolla, California); Matthew J. McMahon (Los Angeles, California) |
| ASSIGNEE(S) | Second Sight Medical Products, Inc. (Sylmar, California) |
| INVENTOR(S) | Robert J. Greenberg (Los Angeles, California); Arup Roy (Valencia, California); Avraham I. Caspi (La Jolla, California); Matthew J. McMahon (Los Angeles, California) |
| ABSTRACT | A visual prosthesis apparatus including a video capture device for capturing a video image, a video processing unit associated with the video capture device, the video processing unit configured to convert the video image to stimulation patterns, and a stimulation system configured to stimulate subject's neural tissue based on the stimulation patterns, wherein the stimulation system provides a span of visual angle matched to the subject's neural tissue being stimulated. |
| FILED | Thursday, January 31, 2008 |
| APPL NO | 12/023907 |
| ART UNIT | 3766 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery: Light, thermal, and electrical application 67/53 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 08578569 | Karnoski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stephen Ray Karnoski (Camarillo, California); Dennis Michael How (Camarillo, California); James F. Jenkins (Cambria, California) |
| ASSIGNEE(S) | United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Stephen Ray Karnoski (Camarillo, California); Dennis Michael How (Camarillo, California); James F. Jenkins (Cambria, California) |
| ABSTRACT | A mechanical coupler that separates at a pre-determined ambient pressure. |
| FILED | Monday, August 08, 2011 |
| APPL NO | 13/204906 |
| ART UNIT | 3677 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Buckles, buttons, clasps, etc. 024/303 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08578759 | Calvo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David C. Calvo (Alexandria, Virginia); Jill P. Bingham (Norfolk, Virginia); Michael Nicholas (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | David C. Calvo (Alexandria, Virginia); Jill P. Bingham (Norfolk, Virginia); Michael Nicholas (Washington, District of Columbia) |
| ABSTRACT | A method and an apparatus for intrusion detection. The apparatus includes an acoustic source, a laser light source, a pressure-sensitive optical fiber including a first end and a second end. The second end is connected to the laser light source and oriented toward the acoustic source. The laser light source generates a laser pulse traveling through the pressure-sensitive optical fiber toward the acoustic source. The laser pulse includes a time-of-flight. The acoustic source generates an acoustic wave. The acoustic wave includes a plurality of evanescent wave fronts. The plurality of evanescent wave fronts, upon scattering from a non-uniform material region, radially contracts the pressure-sensitive optical fiber to alter the time-of-flight of the laser pulse along the pressure-sensitive optical fiber by increasing the fiber length. |
| FILED | Monday, November 07, 2011 |
| APPL NO | 13/290302 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/40.5A0 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08578834 | Tunis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | George C. Tunis (Berlin, Maryland); Scott Kendall (Berlin, Maryland) |
| ASSIGNEE(S) | Hardwire, LLC (Pocomoke City, Maryland) |
| INVENTOR(S) | George C. Tunis (Berlin, Maryland); Scott Kendall (Berlin, Maryland) |
| ABSTRACT | A vehicle includes one or more structural vent channels for blast energy and gas and debris dissipation. The structural enclosure of a vehicle includes a hull floor and encloses or defines a compartment for crew, cargo, or crew and cargo. The channel provides a passage through, around, or through and around the vehicle, by which blast energy and debris can be dissipated from explosions beneath the vehicle. Objects can be mounted within, above, or below the channel with breakaway mounting fixtures. The channel can serve as a storage compartment for objects that would be sacrificed during a blast. |
| FILED | Friday, April 08, 2011 |
| APPL NO | 13/066243 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ordnance 089/36.20 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579117 | Loutherback et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kevin Loutherback (Princeton, New Jersey); James C. Sturm (Princeton, New Jersey); Robert Austin (Princeton, New Jersey); Keith Morton (Princeton, New Jersey); Jason Puchalla (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Kevin Loutherback (Princeton, New Jersey); James C. Sturm (Princeton, New Jersey); Robert Austin (Princeton, New Jersey); Keith Morton (Princeton, New Jersey); Jason Puchalla (Princeton, New Jersey) |
| ABSTRACT | The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ. |
| FILED | Friday, July 24, 2009 |
| APPL NO | 12/509175 |
| ART UNIT | 3653 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Classifying, separating, and assorting solids 29/210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579170 | Leung |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fee Chan Leung (Bel Air, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Fee Chan Leung (Bel Air, Maryland) |
| ABSTRACT | An air breathing battery apparatus is connected to the hollow tubing of a backpack frame to provide an uninterrupted, water-resistant, light-weight power supply during extended remote operations in the field. Air breathing power sources are connected to the hollow tubes of the backpack assembly to provide a constant uninterrupted air supply in a relatively small package that fits easily into the backpack frame with only negligible added weight. The positioning of the air breathing power source in a backpack composed of hollow tubing also protects the battery from inclement weather or when the user is in water, for example, while fording a river or stream, to permit the uninterrupted use of the electronics powered by the battery. |
| FILED | Thursday, January 26, 2012 |
| APPL NO | 13/358524 |
| ART UNIT | 3782 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Package and article carriers 224/576 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579235 | Ganguli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gurudas Ganguli (Arlington, Virginia); Scott S. Chappie (Arlington, Virginia); Leonid I. Roudakov (San Diego, California); Christopher E. Crabtree (Springfield, Virginia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Gurudas Ganguli (Arlington, Virginia); Scott S. Chappie (Arlington, Virginia); Leonid I. Roudakov (San Diego, California); Christopher E. Crabtree (Springfield, Virginia) |
| ABSTRACT | System and method for inducing rapid reentry of orbital debris including determining a spatial extent of the orbital debris, and deploying dust to the orbital debris to enhance the drag on the orbital debris. Small objects with perigee above about 900 km where the debris lifetime can be centuries can be targeted for de-orbiting. |
| FILED | Friday, May 03, 2013 |
| APPL NO | 13/886336 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeronautics and astronautics 244/158.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579434 | Amirparviz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Babak Amirparviz (Mountain View, California); Andrew Lingley (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| INVENTOR(S) | Babak Amirparviz (Mountain View, California); Andrew Lingley (Seattle, Washington) |
| ABSTRACT | Solar cells attached to a contact lens are provided, as well as methods for making the solar cells and contact lenses. The solar cells have electrodes on only one side of the device, which facilitates attachment of the solar cell to a contact lens. In one embodiment, the solar cells are made using a “two sided” process. By using the two-sided process, solar cells of only a few microns in thickness can be fabricated. Such relatively thin solar cells can be incorporated into a contact lens without discomfort to the wearer. By providing an infinitely renewable power source on a contact lens, the solar cells enable the use of electronic components on the contact lens while eliminating the recharging or replacing issues that arise with batteries. |
| FILED | Thursday, October 20, 2011 |
| APPL NO | 13/278026 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optics: Eye examining, vision testing and correcting 351/159.30 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579535 | Crane et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William Mike Crane (Monterey, California); Paul Michael Oppenheimer (Edgewater, Maryland); Marcello Romano (Monterey, California); James Hansen Newman (Pacific Grove, California) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | William Mike Crane (Monterey, California); Paul Michael Oppenheimer (Edgewater, Maryland); Marcello Romano (Monterey, California); James Hansen Newman (Pacific Grove, California) |
| ABSTRACT | A micro-coupling active release mechanism including a shape memory alloy (SMA) cylindrical ring that is fit into a bushing or other mating attachment creating an interference joint held in place by frictional forces. The interference joint can be released upon actuation in which the SMA cylindrical ring is heated causing it to shrink in size, relieving the frictional forces of the interference joint thereby releasing the SMA cylindrical ring from the bushing or other mating attachment. |
| FILED | Thursday, September 09, 2010 |
| APPL NO | 12/878760 |
| ART UNIT | 3679 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 1/0014 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579591 | Ho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John Chen Chiang Ho (San Diego, California); Bo Zheng (San Diego, California); Timothy M. Hollman (San Diego, California); Kevin K. Taft (La Mesa, California); Jang Y. Jo (Chula Vista, California); Anthony C. Jones (San Diego, California) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Windsor Locks, Connecticut) |
| INVENTOR(S) | John Chen Chiang Ho (San Diego, California); Bo Zheng (San Diego, California); Timothy M. Hollman (San Diego, California); Kevin K. Taft (La Mesa, California); Jang Y. Jo (Chula Vista, California); Anthony C. Jones (San Diego, California) |
| ABSTRACT | A compressor impeller includes a hub, main blades and splitter blades. The main blades are equally spaced around the circumference of the hub. Each splitter blade is equally spaced between two adjacent main blades. Each main blade and splitter blade has suction and pressure surfaces formed in substantial compliance with normalized Cartesian coordinate values of X, Y, and Z set forth in Tables 1-4. When connected by smooth, continuing arcs, the normalized Cartesian coordinates form complete main blade and splitter blade shapes that are substantially matched by the main blade and splitter blade shapes of the compressor impeller. |
| FILED | Thursday, October 28, 2010 |
| APPL NO | 12/914335 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Fluid reaction surfaces 416/203 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579859 | Kramer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | George C. Kramer (Galveston, Texas); Guy A. Drew (San Antonio, Texas); Donald J. Deyo (Galveston, Texas); Allen E. Brandenburg (Dripping Springs, Texas); Richard B. Voigt (Texas City, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | George C. Kramer (Galveston, Texas); Guy A. Drew (San Antonio, Texas); Donald J. Deyo (Galveston, Texas); Allen E. Brandenburg (Dripping Springs, Texas); Richard B. Voigt (Texas City, Texas) |
| ABSTRACT | Novel fluid delivery systems are disclosed to improve the delivery of bio-compatible fluids to a patient. The systems can include a housing having a bladder pressurized by a pressurization unit so that fluid flow rate can be controlled, changed and/or monitored. The systems can also include a scale and/or a flow control unit. |
| FILED | Monday, December 27, 2010 |
| APPL NO | 12/978692 |
| ART UNIT | 3763 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery 64/151 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580027 | Campos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raymond Campos (Lancaster, California); Andrew J. Guenthner (Lancaster, California); Timothy S. Haddad (Lancaster, California); Joseph M. Mabry (Lancaster, California) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Raymond Campos (Lancaster, California); Andrew J. Guenthner (Lancaster, California); Timothy S. Haddad (Lancaster, California); Joseph M. Mabry (Lancaster, California) |
| ABSTRACT | Fluoroalkylsilane-treated metal oxide particles and a fluoroelastomeric binder are dispersed in a fluorinated solvent with a low boiling point and applied to a substrate via spray deposition. The spray deposition process rapidly produces a conformal coating that features low surface energy and surface topography with a large range of characteristic length scales and re-entrant curvature, thereby imparting superoleophobicity. The degree of superoleophobicity is readily adjusted by means of altering the ratio of particles to binder. The choice of particle and binder result in coatings with thermal stability for thousands of hours at temperatures up to 200 degrees Celsius as well as desirable mechanical characteristics. |
| FILED | Thursday, August 11, 2011 |
| APPL NO | 13/207562 |
| ART UNIT | 1765 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Compositions: Coating or plastic 16/287.270 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580051 | Chin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Herbert A. Chin (Portland, Connecticut); William P. Ogden (Glastonbury, Connecticut) |
| ASSIGNEE(S) | United Technologies Corporation (Hartford, Connecticut) |
| INVENTOR(S) | Herbert A. Chin (Portland, Connecticut); William P. Ogden (Glastonbury, Connecticut) |
| ABSTRACT | A method of processing steel includes carburizing a martensitic stainless steel work piece to produce a carburized case by utilizing in combination, (i) a composition of the martensitic stainless steel work piece, (ii) a preselected carbon concentration in the carburized case, and (iii) a preselected grain size of the martensitic stainless steel work piece such that the carburized case predominately forms carbides of composition M6C, M2C, M23C6 or combinations thereof. The martensitic stainless steel work piece is then heated to substantially solution the metal carbides. The work piece is then quenched at a cooling rate that is sufficient to avoid substantial precipitation of any carbides during cool down to the martensite start temperature, then given a low temperature temper. In so doing, the carburized case hardened martensitic stainless steel will have balanced mechanical, tribological and corrosion resistance properties for high performance bearing and gear components. |
| FILED | Tuesday, October 09, 2012 |
| APPL NO | 13/647461 |
| ART UNIT | 1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Metal treatment 148/319 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580144 | Chien et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Liang-Chy Chien (Hudson, Ohio); Jeoung Yeon Hwang (Dajeon, South Korea); Jenny-Marie Wong (Tonawanda, New York) |
| ASSIGNEE(S) | Kent State University (Kent, Ohio) |
| INVENTOR(S) | Liang-Chy Chien (Hudson, Ohio); Jeoung Yeon Hwang (Dajeon, South Korea); Jenny-Marie Wong (Tonawanda, New York) |
| ABSTRACT | A composition including nanocomposites formed from blue phase liquid crystals that are stabilized with dopants and nanorods such as metallic nanorods and/or carbon nanotubes. Devices including the compositions are disclosed that provide increases temperature ranges as well as reduction in threshold voltage and turn on voltage, in addition to the inherent blue phase liquid crystal properties of sub-millisecond response time in the field induced Kerr effect. |
| FILED | Friday, April 06, 2012 |
| APPL NO | 13/441027 |
| ART UNIT | 1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Compositions 252/299.10 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580263 | Adams et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gregory P. Adams (Hatboro, Pennsylvania); Eva M. Horak (West Oragne, New Jersey); Louis M. Weiner (Washington, District of Columbia); James D. Marks (Kensington, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Gregory P. Adams (Hatboro, Pennsylvania); Eva M. Horak (West Oragne, New Jersey); Louis M. Weiner (Washington, District of Columbia); James D. Marks (Kensington, California) |
| ABSTRACT | Anti-EGFR family member antibodies and bispecific antibodies comprising one or more anti-EGFR family member antibodies are disclosed. These antibodies can be used to advantage to specifically target forms of cancer associated with the overexpression of members of the EGFR protein family. |
| FILED | Tuesday, November 20, 2007 |
| APPL NO | 12/515522 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/143.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580350 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jor-Shan Choi (El Cerrito, California); Joseph C. Farmer (Tracy, California); Chuck K. Lee (Hayward, California); Jeffrey Walker (Gaithersburg, Maryland); Paige Russell (Las Vegas, Nevada); Jon Kirkwood (Saint Leonard, Maryland); Nancy Yang (Lafayette, California); Victor Champagne (Oxford, Pennsylvania) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California); Sandia Corporation (Albuquerque, New Mexico); The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Jor-Shan Choi (El Cerrito, California); Joseph C. Farmer (Tracy, California); Chuck K. Lee (Hayward, California); Jeffrey Walker (Gaithersburg, Maryland); Paige Russell (Las Vegas, Nevada); Jon Kirkwood (Saint Leonard, Maryland); Nancy Yang (Lafayette, California); Victor Champagne (Oxford, Pennsylvania) |
| ABSTRACT | A method of forming a corrosion resistant neutron absorbing coating comprising the steps of spray or deposition or sputtering or welding processing to form a composite material made of a spray or deposition or sputtering or welding material, and a neutron absorbing material. Also a corrosion resistant neutron absorbing coating comprising a composite material made of a spray or deposition or sputtering or welding material, and a neutron absorbing material. |
| FILED | Wednesday, September 22, 2010 |
| APPL NO | 12/888261 |
| ART UNIT | 1784 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Coating processes 427/455 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580387 | Fedderly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeffry J. Fedderly (Ellicott City, Maryland); Gilbert F. Lee (Greenbelt, Maryland); Curtis A. Martin (Damascus, Maryland); Edward Balizer (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Jeffry J. Fedderly (Ellicott City, Maryland); Gilbert F. Lee (Greenbelt, Maryland); Curtis A. Martin (Damascus, Maryland); Edward Balizer (Bethesda, Maryland) |
| ABSTRACT | A composite armor including a ballistic armor layer and a directly attached polyurea layer. The polyurea layer is the cured reaction product of an isocyanate curing agent and a mixture of diamines having the general formula: H2N-Ph-(C═O)—O—(CH2—CH2—CH2—CH2—O)n—(C═O)-Ph-NH2, wherein in the mixture n in the ranges from 3 to 14 and the weight average value of n is about 9 to 10. Ph represents phenyl. In a preferred embodiment, the polyurea layer is the strike face. The composite armor is useful for light armor applications in which weight is a factor such as military vehicle armor and military boat armor. |
| FILED | Tuesday, September 27, 2011 |
| APPL NO | 13/245901 |
| ART UNIT | 1787 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Stock material or miscellaneous articles 428/423.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580488 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WenYong Chen (Temple City, California); Ravi Bhatia (Duarte, California); Leila Su (Diamond Bar, California); Yate-Ching Yuan (Arcadia, California) |
| ASSIGNEE(S) | City of Hope (Duarte, California) |
| INVENTOR(S) | WenYong Chen (Temple City, California); Ravi Bhatia (Duarte, California); Leila Su (Diamond Bar, California); Yate-Ching Yuan (Arcadia, California) |
| ABSTRACT | A method of generating a chronic myelogenic leukemia (CML) acquired chemoresistant culture model is provided. Such a method may comprise providing a naïve blast crisis CML cell line; administering/contacting the cell line with a mutation-inducing dose of imatinib; maintaining a culture of the treated cell line for a period of time until the treated cell line relapses and repopulates the culture; and determining the repopulated cell culture is a CML acquired chemoresistant cell line by detecting a BCR-ABL mutation, wherein the acquired chemoresistance is achieved by a BCR-ABL mutation. |
| FILED | Friday, October 08, 2010 |
| APPL NO | 12/901139 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580509 | Tomlins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Scott Tomlins (Ann Arbor, Michigan); Daniel Rhodes (Ann Arbor, Michigan); Arul Chinnaiyan (Ann Arbor, Michigan); Rohit Mehra (Ann Arbor, Michigan); Mark A. Rubin (New York, New York); Xiao-Wei Sun (New York, New York); Sven Perner (Ellwaugen, Germany); Charles Lee (Marlborough, Massachusetts); Francesca Demichelis (New York, New York) |
| ASSIGNEE(S) | The Regents of The University of Michigan (Ann Arbor, Michigan); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Scott Tomlins (Ann Arbor, Michigan); Daniel Rhodes (Ann Arbor, Michigan); Arul Chinnaiyan (Ann Arbor, Michigan); Rohit Mehra (Ann Arbor, Michigan); Mark A. Rubin (New York, New York); Xiao-Wei Sun (New York, New York); Sven Perner (Ellwaugen, Germany); Charles Lee (Marlborough, Massachusetts); Francesca Demichelis (New York, New York) |
| ABSTRACT | Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided. |
| FILED | Wednesday, May 30, 2012 |
| APPL NO | 13/483176 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.120 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580870 | Costantino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EnerG2, Technologies, Inc. (Seattle, Washington) |
| ASSIGNEE(S) | EnerG2 Technologies, Inc. (Seattle, Washington) |
| INVENTOR(S) | Henry R. Costantino (Woodinville, Washington); Aaron Feaver (Seattle, Washington); William D. Scott (Seattle, Washington) |
| ABSTRACT | The present application is generally directed to activated carbon materials and methods for making the same. The disclosed methods comprise rapidly freezing synthetically prepared polymer gel particles. The methods further comprise drying, pyrolyzing, and activating steps to obtain an activated carbon material of high porosity. The disclosed methods represent viable manufacturing processes for the preparation of activated carbon materials. |
| FILED | Friday, September 21, 2012 |
| APPL NO | 13/624689 |
| ART UNIT | 1762 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Synthetic resins or natural rubbers 523/309 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580958 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Loon-Seng Tan (Centerville, Ohio); Ramamurthi Kannan (Cincinnati, Ohio); Matthew Dalton (Bellbrook, Ohio) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Loon-Seng Tan (Centerville, Ohio); Ramamurthi Kannan (Cincinnati, Ohio); Matthew Dalton (Bellbrook, Ohio) |
| ABSTRACT | Provided are novel 2PA-active monomers of the formula: wherein Y═H, acrylic or methacrylic moiety; R is a linear or branched alkyl group, —CmH2m+1, where m=1-6 or an alkylether group, —(CH2CH2O)pMe, where p=1-5. The number of R′—(OH)x groups, attached to the phenyl rings of the triarylamine moiety either in a para or a meta position, could be 3 or 6 per molecule, or mixtures of molecules containing 3, 4, 5, 6 in various ratios and wherein x=1, 2, or 3. R′ is a linear or branched alkyl group such as —CmH2m, where m=1-6, i.e. linear —(CH2)m, where m=2-6, or branched alkyl group such as —CH2CH(R″)—, where R″═—(CH2)lCH3, where l=2-6. |
| FILED | Thursday, September 22, 2011 |
| APPL NO | 13/239606 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Organic compounds 544/180 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581160 | Sanford |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Matthew Sanford (Bel Alton, Maryland) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Matthew Sanford (Bel Alton, Maryland) |
| ABSTRACT | A gyroscopic stabilizer has a ring mounted at a missile rocket nozzle exit for rotation about the exit. The ring bears vanes extended inwardly into gases exiting from the nozzle and configured for rotation by the exiting gases so that the rotating mass of the ring gyroscopically stabilizes the missile. The ring may be mounted by a bearing having rolling elements or sliding surfaces. The axial length of the ring may be substantially less than its diameter. The ring has a low moment of inertia and is accelerated to stabilizing speed by vanes minimally impeding the exiting gases. When the stabilizer is used on a rocket propelled missile launched from a tube, the missile is fully stabilized in the tube before burnout and there is no rotational friction between the tube and the missile. |
| FILED | Wednesday, March 31, 2010 |
| APPL NO | 12/799010 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeronautics and astronautics 244/3.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581306 | Blick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Robert H. Blick (Madison, Wisconsin); Chulki Kim (Madison, Wisconsin); Jonghoo Park (Madison, Wisconsin) |
| ABSTRACT | A nanoscale electron shuttle with two elastically mounted conductors positioned within a gap between conductors produces asymmetrical electron conduction between the conductors when the conductors receive an AC signal to provide for rectification, detection and/or power harvesting. |
| FILED | Monday, February 18, 2013 |
| APPL NO | 13/769723 |
| ART UNIT | 2821 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/213 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581605 | White et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Henry S White (Salt Lake City, Utah); Ryan J White (Salt Lake City, Utah); Eric N Ervin (Salt Lake City, Utah) |
| ASSIGNEE(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| INVENTOR(S) | Henry S White (Salt Lake City, Utah); Ryan J White (Salt Lake City, Utah); Eric N Ervin (Salt Lake City, Utah) |
| ABSTRACT | A nanopore device includes a membrane having a nanopore extending there through forming a channel from a first side of the membrane to a second side of the membrane. The surface of the channel and first side of the membrane are modified with a hydrophobic coating. A first lipid monolayer is deposited on the first side of the membrane, and a second lipid monolayer is deposited on the second side of the membrane, wherein the hydrophobic coating causes spontaneous generation of a lipid bilayer across the nanopore orifice. Sensing entities, such as a protein ion channel, can be inserted and removed from the bilayer by adjusting transmembrane pressure, and adapter molecules can be electrostatically trapped in the ion channel by applying high transmembrane voltages, while resistance or current flow through the sensing entity can be measured electrically. |
| FILED | Wednesday, June 30, 2010 |
| APPL NO | 12/827503 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/693 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581771 | Bradley |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Timothy Bradley (Loogootee, Indiana) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Timothy Bradley (Loogootee, Indiana) |
| ABSTRACT | A system is disclosed to identify authorized EO devices and unauthorized EO devices within a scene. The system hampers the operation of the unauthorized EO devices detected within the scene. |
| FILED | Wednesday, May 12, 2010 |
| APPL NO | 12/778892 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Communications: Directive radio wave systems and devices 342/14 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581911 | Becker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael J. Becker (Half Moon Bay, California); Keith Copenhagen (Orinda, California); Murray Taylor (Phoenix, Maryland) |
| ASSIGNEE(S) | Intific, Inc. (Hampton, Virginia) |
| INVENTOR(S) | Michael J. Becker (Half Moon Bay, California); Keith Copenhagen (Orinda, California); Murray Taylor (Phoenix, Maryland) |
| ABSTRACT | A system and method for modifying facial animations to include expression and microexpression information is disclosed. Particularly, a system and method for applying actor-generated expression data to a facial animation, either in realtime or in storage is disclosed. Present embodiments may also be incorporated into a larger training program, designed to train users to recognize various expressions and microexpressions. |
| FILED | Friday, October 02, 2009 |
| APPL NO | 12/573003 |
| ART UNIT | 2679 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Computer graphics processing and selective visual display systems 345/473 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582100 | Tucker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | John E. Tucker (Centreville, Virginia); John F. Reintjes (Alexandria, Virginia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | John E. Tucker (Centreville, Virginia); John F. Reintjes (Alexandria, Virginia) |
| ABSTRACT | An optical fluid monitoring system for imaging debris and other particles in a flowing fluid. The system can have multiple sensors (camera and viewing port) connected to a single, remotely located, laser and computer. The system can also include multiple lasers, viewing ports and cameras to be located at different locations in a flow, with each sensor being configured to image a different particle size range. The system can simultaneously image fluid flows on different pieces of equipment. |
| FILED | Tuesday, June 18, 2013 |
| APPL NO | 13/920769 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/335 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582267 | Pellegrino |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John Pellegrino (Westford, Massachusetts) |
| ASSIGNEE(S) | The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | John Pellegrino (Westford, Massachusetts) |
| ABSTRACT | An in-rush current limiting system has a fast response time so that it can be used with power supplies that turn on and off rapidly. The system dissipates very little power during the normal mode of operation. This is achieved, in various embodiments, by connecting a regulator in series with a load capacitance and in parallel with the system load. |
| FILED | Friday, March 05, 2010 |
| APPL NO | 12/718526 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Electricity: Electrical systems and devices 361/93.900 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582648 | Berman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Steven T. Berman (New York, New York); Paul F. Greier (Carmel, New York); Kenneth C. Ho (Yorktown Heights, New York); Richard I. Kaufman (Somers, New York); Alphonso P. Lanzetta (Marlboro, New York); Michael P. Mastro (Yorktown Heights, New York); Steven Edward Millman (Spring Valley, New York); Ron Ridgeway (New Milford, Connecticut); Kai Schleupen (Yorktown Heights, New York); Steven Lorenz Wright (Cortlandt Manor, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Steven T. Berman (New York, New York); Paul F. Greier (Carmel, New York); Kenneth C. Ho (Yorktown Heights, New York); Richard I. Kaufman (Somers, New York); Alphonso P. Lanzetta (Marlboro, New York); Michael P. Mastro (Yorktown Heights, New York); Steven Edward Millman (Spring Valley, New York); Ron Ridgeway (New Milford, Connecticut); Kai Schleupen (Yorktown Heights, New York); Steven Lorenz Wright (Cortlandt Manor, New York) |
| ABSTRACT | A video processing method and system for generating a foveated video display with sections having different resolutions uses a network channel for communicating video images having video sections of different resolutions, and includes a video transmission system for processing and transmitting the received video images over the network channel. The system assigns a larger portion of the network channel's bandwidth to a video section with higher resolution. Further, the system includes a video receiving system for receiving and seamlessly combining the first and second video sections of different resolutions to form an output video image on a display device, and a control unit for sending one or more video control parameters to the video transmission system to control capturing, transmitting and processing of the video images. |
| FILED | Tuesday, February 17, 2009 |
| APPL NO | 12/372458 |
| ART UNIT | 2485 — Recording and Compression |
| CURRENT CPC | Pulse or digital communications 375/240.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582972 | Small et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Benjamin A. Small (New York, New York); Assaf Shacham (Magshimim, Israel); Keren Bergman (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Benjamin A. Small (New York, New York); Assaf Shacham (Magshimim, Israel); Keren Bergman (Princeton, New Jersey) |
| ABSTRACT | An optical data storage system and method of use thereof are presented. The optical data storage system includes one or more optical buffer modules connected in series. Each optical buffer module includes a cross connect. Each cross connect is connected, by a pair of inputs and outputs, to an optical data storage unit, for example, a fiber delay line, by a pair to either an optical packet network or a cross connect of a first adjacent buffer module in the series, and by a pair to a cross connect of a second adjacent buffer module in the series. The buffer module also includes a read signal output line which is connected to a read signal input line of the second adjacent buffer module for transmitting a read signal. A control module within each buffer module directs the passage of data through the cross connect. |
| FILED | Friday, August 31, 2007 |
| APPL NO | 12/438661 |
| ART UNIT | 2637 — Optical Communications |
| CURRENT CPC | Optical communications 398/101 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582985 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Frankie Y. Liu (Palo Alto, California); Dinesh D. Patil (Fremont, California) |
| ASSIGNEE(S) | Oracle International Corporation (Redwood Shores, California) |
| INVENTOR(S) | Frankie Y. Liu (Palo Alto, California); Dinesh D. Patil (Fremont, California) |
| ABSTRACT | An optical receiver is described. This optical receiver has two operating modes: a calibration mode and a normal mode. During the normal mode, switches are used to electrically couple an input of a transimpedance amplifier (TIA) to an optical-to-electrical (OE) converter that receives an optical signal and provides a corresponding analog electrical signal. Moreover, during the calibration mode, the switches are used to electrically isolate the input of the TIA from the OE converter while maintaining a feedback path from an output of the TIA to the input of the TIA, thereby ensuring proper bias of the TIA during calibration. Furthermore, a frequency response of the TIA during the normal mode is substantially unchanged over an operating bandwidth of the TIA by the capability to electrically isolate the input of the TIA from the OE converter during the calibration mode. |
| FILED | Thursday, June 09, 2011 |
| APPL NO | 13/157165 |
| ART UNIT | 2634 — Digital Communications |
| CURRENT CPC | Transmission H04B 10/695 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583049 | Collins, III |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas E. Collins, III (Tyngsboro, Massachusetts) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Thomas E. Collins, III (Tyngsboro, Massachusetts) |
| ABSTRACT | Techniques are disclosed for optimization of RF converters. The techniques can be employed, for instance, in RF converters implemented in semiconductor materials (system-on-chip, or chip set) or with discrete components on a printed circuit board. In any such cases, the RF converter system can be configured with one or more actuators to adjust performance, one or more sensor to assess the performance (e.g., linearity of RF converter) and parameters of interest (e.g., ambient temperature, and a control block for controlling the sensors and actuators. The configuration allows the RF converter to autonomously self-optimize for linearity or other parameters of interest such as gain, noise figure, and dynamic range, across a broad range of variables. |
| FILED | Tuesday, September 08, 2009 |
| APPL NO | 12/555376 |
| ART UNIT | 2649 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Telecommunications 455/67.110 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583286 | Fleischer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jason G. Fleischer (Del Mar, California); Botond Szatmáry (Del Mar, California); Donald B. Hutson (San Diego, California); Douglas A. Moore (San Diego, California); James A. Snook (San Diego, California); Gerald M. Edelman (La Jolla, California); Jeffrey L. Krichmar (Cardiff-by-the-Sea, California) |
| ASSIGNEE(S) | Neurosciences Research Foundation, Inc. (La Jolla, California) |
| INVENTOR(S) | Jason G. Fleischer (Del Mar, California); Botond Szatmáry (Del Mar, California); Donald B. Hutson (San Diego, California); Douglas A. Moore (San Diego, California); James A. Snook (San Diego, California); Gerald M. Edelman (La Jolla, California); Jeffrey L. Krichmar (Cardiff-by-the-Sea, California) |
| ABSTRACT | A brain-based device (BBD) for moving in a real-world environment has sensors that provide data about the environment, actuators to move the BBD, and a hybrid controller which includes a neural controller having a simulated nervous system being a model of selected areas of the human brain and a non-neural controller based on a computational algorithmic network. The neural controller and non-neural controller interact with one another to control movement of the BBD. |
| FILED | Wednesday, April 04, 2012 |
| APPL NO | 13/439702 |
| ART UNIT | 3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Data processing: Generic control systems or specific applications 7/259 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583432 | Biadsy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fadi Biadsy (New York, New York); Lidia Mangu (New York, New York); Hagen Soltau (Yorktown Heights, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Fadi Biadsy (New York, New York); Lidia Mangu (New York, New York); Hagen Soltau (Yorktown Heights, New York) |
| ABSTRACT | Methods and systems for automatic speech recognition and methods and systems for training acoustic language models are disclosed. One system for automatic speech recognition includes a dialect recognition unit and a controller. The dialect recognition unit is configured to analyze acoustic input data to identify portions of the acoustic input data that conform to a general language and to identify portions of the acoustic input data that conform to at least one dialect of the general language. In addition, the controller is configured to apply a general language model and at least one dialect language model to the input data to perform speech recognition by dynamically selecting between the models in accordance with each of the identified portions. |
| FILED | Wednesday, July 25, 2012 |
| APPL NO | 13/557983 |
| ART UNIT | 2659 — Linguistics, Speech Processing and Audio Compression |
| CURRENT CPC | Data processing: Speech signal processing, linguistics, language translation, and audio compression/decompression 74/235 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583442 | Large |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Edward W. Large (Boca Raton, Florida) |
| ASSIGNEE(S) | Circular Logic, LLC (Philadelphia, Pennsylvania); Florida Atlantic University Research Corporation (Boca Raton, Florida) |
| INVENTOR(S) | Edward W. Large (Boca Raton, Florida) |
| ABSTRACT | A method for mimicking the auditory system's response to rhythm of an input signal having a time varying structure comprising the steps of receiving a time varying input signal x(t) to a network of n nonlinear oscillators, each oscillator having a different natural frequency of oscillation and obeying a dynamical equation of the form wherein ω represents the response frequency, r is the amplitude of the oscillator and φ is the phase of the oscillator. Generating at least one frequency output from said network useful for describing said varying structure. |
| FILED | Friday, January 28, 2011 |
| APPL NO | 13/016602 |
| ART UNIT | 2658 — Linguistics, Speech Processing and Audio Compression |
| CURRENT CPC | Data processing: Speech signal processing, linguistics, language translation, and audio compression/decompression 74/270 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583573 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cheryl M. Smith (Panama City, Florida); John C. Hyland (Panama City, Florida) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Cheryl M. Smith (Panama City, Florida); John C. Hyland (Panama City, Florida) |
| ABSTRACT | A mine line detection method to identify mine-like contacts (MLCs) that fit into mine line patterns dictated by standard mine laying protocol. In general, MLCs define a minefield where the minefield has both mines and false alarms. The method classifies every MLC into one of three classes: fixed—a mine line pattern with fixed mine spacing; random—a mine line pattern with random mine spacing; or false alarm—the MLC does not fit into a mine line pattern and is not considered a mine. The method requires no knowledge of either the sensor probability of detection (Pd) or probability of false alarm (Pfa); nonetheless, it significantly improves both. A nonparametric anomaly detector identifies regions with unusually high MLC density for more detailed analysis. Suspected regions are analyzed for unusually regular patterns of MLCs. Probabilities that the observed target densities and target patterns could occur by chance are estimated. |
| FILED | Tuesday, October 19, 2010 |
| APPL NO | 12/925396 |
| ART UNIT | 2122 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Artificial intelligence 76/14 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583714 | Turner |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Steven E. Turner (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Steven E. Turner (Nashua, New Hampshire) |
| ABSTRACT | A DDS system is disclosed that is configured to provide a variable clock delay that allows timing of data coming out of the ROM to be adjusted. In one example case, a DDS system is provided that includes a ROM for storing phase-to-amplitude conversion data and generating digital amplitude values corresponding to respective digital phase values, and delay circuitry for adjusting timing of data output by the ROM to compensate for propagation delay of the DDS system. The delay circuitry may include, for instance, delay elements that can be selected alone or in combination to adjust the timing. The timing can be adjusted, for example, by adjusting delay of a clock signal that clocks one or more ROM pipeline registers. The system may include a phase accumulator and DAC, and adjusting the timing may include adjusting delay of a clock signal that clocks one or more DAC pipeline registers. |
| FILED | Friday, February 12, 2010 |
| APPL NO | 12/704828 |
| ART UNIT | 2184 — Computer Architecture and I/O |
| CURRENT CPC | Electrical computers: Arithmetic processing and calculating 78/271 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08584099 | Abi-Antoun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marwan Elia Abi-Antoun (Pittsburgh, Pennsylvania); Jonathan Erik Aldrich (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Marwan Elia Abi-Antoun (Pittsburgh, Pennsylvania); Jonathan Erik Aldrich (Pittsburgh, Pennsylvania) |
| ABSTRACT | Apparatuses and methods for producing run-time architectures of computer program modules. One embodiment includes creating an abstract graph from the computer program module and from containment information corresponding to the computer program module, wherein the abstract graph has nodes including types and objects, and wherein the abstract graph relates an object to a type, and wherein for a specific object the abstract graph relates the specific object to a type containing the specific object; and creating a runtime graph from the abstract graph, wherein the runtime graph is a representation of the true runtime object graph, wherein the runtime graph represents containment information such that, for a specific object, the runtime graph relates the specific object to another object that contains the specific object. |
| FILED | Friday, June 27, 2008 |
| APPL NO | 12/215476 |
| ART UNIT | 2197 — Computer Architecture and I/O |
| CURRENT CPC | Data processing: Software development, installation, and management 717/131 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 08578708 | Bollinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Benjamin R. Bollinger (Windsor, Vermont); Lee Doyle (Lebanon, New Hampshire); Michael Neil Scott (West Labanon, New Hampshire); Troy O. McBride (Norwich, Vermont); Andrew Shang (Lebanon, New Hampshire) |
| ASSIGNEE(S) | SustainX, Inc. (Seabrook, New Hampshire) |
| INVENTOR(S) | Benjamin R. Bollinger (Windsor, Vermont); Lee Doyle (Lebanon, New Hampshire); Michael Neil Scott (West Labanon, New Hampshire); Troy O. McBride (Norwich, Vermont); Andrew Shang (Lebanon, New Hampshire) |
| ABSTRACT | In various embodiments, compressed-gas energy storage and recovery systems feature one or more valves, which may be disposed within end caps of cylinder assemblies in which gas is expanded and/or compressed, for admitting fluid to and/or exhausting fluid from the cylinder assembly. |
| FILED | Wednesday, November 30, 2011 |
| APPL NO | 13/307163 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Power plants 060/398 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08578860 | Post |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Richard F. Post (Walnut Creek, California) |
| ABSTRACT | Inductrack III configurations are suited for use in transporting heavy freight loads. Inductrack III addresses a problem associated with the cantilevered track of the Inductrack II configuration. The use of a cantilevered track could present mechanical design problems in attempting to achieve a strong enough track system such that it would be capable of supporting very heavy loads. In Inductrack III, the levitating portion of the track can be supported uniformly from below, as the levitating Halbach array used on the moving vehicle is a single-sided one, thus does not require the cantilevered track as employed in Inductrack II. |
| FILED | Thursday, March 07, 2013 |
| APPL NO | 13/788956 |
| ART UNIT | 3617 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Railways 14/281 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579209 | Grubelich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mark C. Grubelich (Albuquerque, New Mexico); Gerold Yonas (Albuquerque, New Mexico) |
| ASSIGNEE(S) | Sandia Corporation (Albuquerque, New Mexico) |
| INVENTOR(S) | Mark C. Grubelich (Albuquerque, New Mexico); Gerold Yonas (Albuquerque, New Mexico) |
| ABSTRACT | A gas powered fluid gun for propelling a stream or slug of a fluid at high velocity toward a target. Recoil mitigation is provided that reduces or eliminates the associated recoil forces, with minimal or no backwash. By launching a quantity of water in the opposite direction, net momentum forces are reduced or eliminated. Examples of recoil mitigation devices include a cone for making a conical fluid sheet, a device forming multiple impinging streams of fluid, a cavitating venturi, one or more spinning vanes, or an annular tangential entry/exit. |
| FILED | Thursday, November 18, 2010 |
| APPL NO | 12/948801 |
| ART UNIT | 3752 — Fluid Handling and Dispensing |
| CURRENT CPC | Fluid sprinkling, spraying, and diffusing 239/337 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579451 | Galvez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Miguel Galvez (Danvers, Massachusetts); Kenneth Grossman (Beverly, Massachusetts); David Betts (Peabody, Massachusetts) |
| ASSIGNEE(S) | Osram Sylvania Inc. (Danvers, Massachusetts) |
| INVENTOR(S) | Miguel Galvez (Danvers, Massachusetts); Kenneth Grossman (Beverly, Massachusetts); David Betts (Peabody, Massachusetts) |
| ABSTRACT | There is herein described a lamp for providing white light comprising a plurality of light sources positioned on a substrate. Each of said light sources comprises a blue light emitting diode (LED) and a dome that substantially covers said LED. A first portion of said blue light from said LEDs is transmitted through said domes and a second portion of said blue light is converted into a red light by a first phosphor contained in said domes. A cover is disposed over all of said light sources that transmits at least a portion of said red and blue light emitted by said light sources. The cover contains a second phosphor that emits a yellow light in response to said blue light. The red, blue and yellow light combining to form the white light and the white light having a color rendering index (CRI) of at least about 80. |
| FILED | Thursday, September 15, 2011 |
| APPL NO | 13/233592 |
| ART UNIT | 2875 — Optics |
| CURRENT CPC | Illumination 362/84 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579593 | Campbell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christian X. Campbell (Oviedo, Florida); John J. Marra (Winter Springs, Florida) |
| ASSIGNEE(S) | Siemens Energy, Inc. (Orlando, Florida) |
| INVENTOR(S) | Christian X. Campbell (Oviedo, Florida); John J. Marra (Winter Springs, Florida) |
| ABSTRACT | An airfoil (10) is provided with a tip (12) having an opening (14) to a center channel (24). A damping element (16) is inserted within the opening of the center channel, to reduce an induced vibration of the airfoil. The mass of the damping element, a spring constant of the damping element within the center channel, and/or a mounting location (58) of the damping element within the center channel may be adjustably varied, to shift a resonance frequency of the airfoil outside a natural operating frequency of the airfoil. |
| FILED | Friday, November 06, 2009 |
| APPL NO | 12/613957 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Fluid reaction surfaces 416/229.A00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580054 | Pagoria et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Philip F. Pagoria (Livermore, California); Mao X. Zhang (Mountain House, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Philip F. Pagoria (Livermore, California); Mao X. Zhang (Mountain House, California) |
| ABSTRACT | In one embodiment, a melt-castable energetic material comprises at least one of: 3,5-bis(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazole (DNFO), and 3-(4-amino-1,2,5-oxadiazol-3-yl)-5-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazole (ANFO). In another embodiment, a method for forming a melt-castable energetic material includes reacting 3,5-bis(4-amino-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazole (DAFO) with oxygen or an oxygen-containing compound to form a mixture of at least: DNFO, and ANFO. |
| FILED | Wednesday, April 04, 2012 |
| APPL NO | 13/439780 |
| ART UNIT | 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Explosive and thermic compositions or charges 149/92 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580096 | St. Martin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Edward J. St. Martin (Libertyville, Illinois); YuPo J. Lin (Naperville, Illinois) |
| ASSIGNEE(S) | Uchicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | Edward J. St. Martin (Libertyville, Illinois); YuPo J. Lin (Naperville, Illinois) |
| ABSTRACT | A method for producing succinic acid is provided, which comprises circulating a fermentation broth containing succinate ion through an electrodeionization apparatus. The apparatus comprises an anode; a cathode; a stacked ion-exchange assembly comprising a one or more oriented ion-exchange units between the anode and the cathode. Each ion-exchange unit comprises a porous ion-exchange resin wafer including an inlet and an outlet together are adapted to circulate a liquid reaction stream containing a carboxylate anion from a fermentor through the resin wafer; a flow-distributing gasket for circulating a product stream through a product reservoir; an anion exchange membrane for transporting at least a portion of the carboxylate anion to the product stream; and a bipolar ion-exchange membrane to direct protons toward the cathode and into the product stream and to direct hydroxyl ions toward the anode and into the reaction stream in the resin wafer of an adjacent ion-exchange unit. |
| FILED | Thursday, September 29, 2011 |
| APPL NO | 13/248231 |
| ART UNIT | 1756 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemistry: Electrical and wave energy 24/524 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580100 | Feng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hsien-Ping Feng (Watertown, Massachusetts); Gang Chen (Carlisle, Massachusetts); Yu Bo (Chesnut Hill, Massachusetts); Zhifeng Ren (Newton, Massachusetts); Shuo Chen (Newton, Massachusetts); Bed Poudel (Newtonville, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Trustees of Boston College (Chestnutt Hill, Massachusetts); GMZ Energy, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Hsien-Ping Feng (Watertown, Massachusetts); Gang Chen (Carlisle, Massachusetts); Yu Bo (Chesnut Hill, Massachusetts); Zhifeng Ren (Newton, Massachusetts); Shuo Chen (Newton, Massachusetts); Bed Poudel (Newtonville, Massachusetts) |
| ABSTRACT | Methods of forming a conductive metal layers on substrates are disclosed which employ a seed layer to enhance bonding, especially to smooth, low-roughness or hydrophobic substrates. In one aspect of the invention, the seed layer can be formed by applying nanoparticles onto a surface of the substrate; and the metallization is achieved by electroplating an electrically conducting metal onto the seed layer, whereby the nanoparticles serve as nucleation sites for metal deposition. In another approach, the seed layer can be formed by a self-assembling linker material, such as a sulfur-containing silane material. |
| FILED | Thursday, February 24, 2011 |
| APPL NO | 12/932372 |
| ART UNIT | 1759 — Semiconductors/Memory |
| CURRENT CPC | Electrolysis: Processes, compositions used therein, and methods of preparing the compositions 25/135 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580130 | Mao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Samuel S. Mao (Castro Valley, California); Costas P. Grigoropoulos (Berkeley, California); David J. Hwang (El Cerrito, California); Andrew M. Minor (El Cerrito, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Samuel S. Mao (Castro Valley, California); Costas P. Grigoropoulos (Berkeley, California); David J. Hwang (El Cerrito, California); Andrew M. Minor (El Cerrito, California) |
| ABSTRACT | Laser-assisted apparatus and methods for performing nanoscale material processing, including nanodeposition of materials, can be controlled very precisely to yield both simple and complex structures with sizes less than 100 nm. Optical or thermal energy in the near field of a photon (laser) pulse is used to fabricate submicron and nanometer structures on a substrate. A wide variety of laser material processing techniques can be adapted for use including, subtractive (e.g., ablation, machining or chemical etching), additive (e.g., chemical vapor deposition, selective self-assembly), and modification (e.g., phase transformation, doping) processes. Additionally, the apparatus can be integrated into imaging instruments, such as SEM and TEM, to allow for real-time imaging of the material processing. |
| FILED | Tuesday, December 16, 2008 |
| APPL NO | 12/743550 |
| ART UNIT | 1713 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Etching a substrate: Processes 216/65 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580149 | Payne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stephen A. Payne (Castro Valley, California); Nerine J. Cherepy (Oakland, California); Giulia E. Hull (Rome, Italy); Alexander D. Drobshoff (Livermore, California); Arnold Burger (Nashville, Tennessee) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California); Fisk University (Nashville, Tennessee) |
| INVENTOR(S) | Stephen A. Payne (Castro Valley, California); Nerine J. Cherepy (Oakland, California); Giulia E. Hull (Rome, Italy); Alexander D. Drobshoff (Livermore, California); Arnold Burger (Nashville, Tennessee) |
| ABSTRACT | In one embodiment, a material comprises a crystal comprising strontium iodide providing at least 50,000 photons per MeV. A scintillator radiation detector according to another embodiment includes a scintillator optic comprising europium-doped strontium iodide providing at least 50,000 photons per MeV. A scintillator radiation detector in yet another embodiment includes a scintillator optic comprising SrI2 and BaI2, wherein a ratio of SrI2 to BaI2 is in a range of between 0:1 A method for manufacturing a crystal suitable for use in a scintillator includes mixing strontium iodide-containing crystals with a source of Eu2+, heating the mixture above a melting point of the strontium iodide-containing crystals, and cooling the heated mixture near the seed crystal for growing a crystal. Additional materials, systems, and methods are presented. |
| FILED | Tuesday, October 21, 2008 |
| APPL NO | 12/255375 |
| ART UNIT | 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Compositions 252/301.4H0 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580222 | Pol et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vilas G. Pol (Westmont, Illinois); Pappannan Thiyagarajan (Clarksburg, Maryland) |
| ASSIGNEE(S) | Uchicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | Vilas G. Pol (Westmont, Illinois); Pappannan Thiyagarajan (Clarksburg, Maryland) |
| ABSTRACT | A single step process for degrading plastic waste by converting the plastic waste into carbonaceous products via thermal decomposition of the plastic waste by placing the plastic waste into a reactor, heating the plastic waste under an inert or air atmosphere until the temperature of about 700° C. is achieved, allowing the reactor to cool down, and recovering the resulting decomposition products therefrom. The decomposition products that this process yields are carbonaceous materials, and more specifically carbon nanotubes having a partially filled core (encapsulated) adjacent to one end of the nanotube. Additionally, in the presence of a transition metal compound, this thermal decomposition process produces multi-walled carbon nanotubes. |
| FILED | Friday, March 16, 2012 |
| APPL NO | 13/422811 |
| ART UNIT | 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemistry of inorganic compounds 423/447.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580350 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jor-Shan Choi (El Cerrito, California); Joseph C. Farmer (Tracy, California); Chuck K. Lee (Hayward, California); Jeffrey Walker (Gaithersburg, Maryland); Paige Russell (Las Vegas, Nevada); Jon Kirkwood (Saint Leonard, Maryland); Nancy Yang (Lafayette, California); Victor Champagne (Oxford, Pennsylvania) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California); Sandia Corporation (Albuquerque, New Mexico); The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Jor-Shan Choi (El Cerrito, California); Joseph C. Farmer (Tracy, California); Chuck K. Lee (Hayward, California); Jeffrey Walker (Gaithersburg, Maryland); Paige Russell (Las Vegas, Nevada); Jon Kirkwood (Saint Leonard, Maryland); Nancy Yang (Lafayette, California); Victor Champagne (Oxford, Pennsylvania) |
| ABSTRACT | A method of forming a corrosion resistant neutron absorbing coating comprising the steps of spray or deposition or sputtering or welding processing to form a composite material made of a spray or deposition or sputtering or welding material, and a neutron absorbing material. Also a corrosion resistant neutron absorbing coating comprising a composite material made of a spray or deposition or sputtering or welding material, and a neutron absorbing material. |
| FILED | Wednesday, September 22, 2010 |
| APPL NO | 12/888261 |
| ART UNIT | 1784 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Coating processes 427/455 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580397 | Omary |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mohammad A. Omary (Denton, Texas) |
| ASSIGNEE(S) | University of North Texas (Denton, Texas) |
| INVENTOR(S) | Mohammad A. Omary (Denton, Texas) |
| ABSTRACT | Homoleptic square planar complexes [M(NΛN)2], wherein two identical NΛN bidentate anionic ligands are coordinated to the M(II) metal center, including bidentate square planar complexes of triazolates, possess optical and electrical properties that make them useful for a wide variety of optical and electrical devices and applications. In particular, the complexes are useful for obtaining white or monochromatic organic light-emitting diodes (“OLEDs”). Improved white organic light emitting diode (“WOLED”) designs have improved efficacy and/or color stability at high brightness in single- or two-emitter white or monochrome OLEDs that utilize homoleptic square planar complexes, including bis[3,5-bis(2-pyridyl)-1,2,4-triazolato]platinum(II) (“Pt(ptp)2”). |
| FILED | Wednesday, July 08, 2009 |
| APPL NO | 13/055974 |
| ART UNIT | 1786 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Stock material or miscellaneous articles 428/690 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580430 | Chiang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yet-Ming Chiang (Framingham, Massachusetts); William Douglas Moorehead (Virginia Beach, Virginia) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Yet-Ming Chiang (Framingham, Massachusetts); William Douglas Moorehead (Virginia Beach, Virginia) |
| ABSTRACT | An energy storage device includes a first electrode comprising a first material and a second electrode comprising a second material, at least a portion of the first and second materials forming an interpenetrating network when dispersed in an electrolyte, the electrolyte, the first material and the second material are selected so that the first and second materials exert a repelling force on each other when combined. An electrochemical device, includes a first electrode in electrical communication with a first current collector; a second electrode in electrical communication with a second current collector; and an ionically conductive medium in ionic contact with said first and second electrodes, wherein at least a portion of the first and second electrodes form an interpenetrating network and wherein at least one of the first and second electrodes comprises an electrode structure providing two or more pathways to its current collector. |
| FILED | Friday, July 13, 2012 |
| APPL NO | 13/549064 |
| ART UNIT | 1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Chemistry: Electrical current producing apparatus, product, and process 429/209 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580438 | Farmer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Joseph C. Farmer (Tracy, California); Michael Stadermann (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Joseph C. Farmer (Tracy, California); Michael Stadermann (Livermore, California) |
| ABSTRACT | A monolithic three-dimensional electrochemical energy storage system is provided on an aerogel or nanotube scaffold. An anode, separator, cathode, and cathodic current collector are deposited on the aerogel or nanotube scaffold. |
| FILED | Tuesday, December 14, 2010 |
| APPL NO | 12/967232 |
| ART UNIT | 1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Chemistry: Electrical current producing apparatus, product, and process 429/235 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580536 | McBrayer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brett McBrayer (Sacramento, California); Tarana Shaghasi (Lafayette, California); Elena Vlasenko (Davis, California) |
| ASSIGNEE(S) | Novozymes, Inc. (Davis, California) |
| INVENTOR(S) | Brett McBrayer (Sacramento, California); Tarana Shaghasi (Lafayette, California); Elena Vlasenko (Davis, California) |
| ABSTRACT | The present invention relates to enzyme compositions for high temperature saccharification of cellulosic material and to uses thereof. |
| FILED | Friday, November 05, 2010 |
| APPL NO | 12/940952 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/41 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580541 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bin Yang (Richland, Washington); Charles E. Wyman (Riverside, California) |
| ASSIGNEE(S) | The Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Bin Yang (Richland, Washington); Charles E. Wyman (Riverside, California) |
| ABSTRACT | Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment enhances cellulase availability in cellulose conversion and allows for the determination of optimized pretreatment conditions. Additionally, ethanol yields from a Simultaneous Saccharification and Fermentation process are improved 5-25% by treatment with a lignin-blocking polypeptide and/or protein. |
| FILED | Tuesday, December 07, 2010 |
| APPL NO | 12/962366 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/161 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580599 | Rim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seung Bum Rim (Palo Alto, California); Taeseok Kim (San Jose, California); David D. Smith (Campbell, California); Peter J. Cousins (Menlo Park, California) |
| ASSIGNEE(S) | SunPower Corporation (San Jose, California) |
| INVENTOR(S) | Seung Bum Rim (Palo Alto, California); Taeseok Kim (San Jose, California); David D. Smith (Campbell, California); Peter J. Cousins (Menlo Park, California) |
| ABSTRACT | Methods of fabricating bypass diodes for solar cells are described. In one embodiment, a method includes forming a first conductive region of a first conductivity type above a substrate of a solar cell. A second conductive region of a second conductivity type is formed on the first conductive region. In another embodiment, a method includes forming a first conductive region of a first conductivity type above a substrate of a solar cell. A second conductive region of a second conductivity type is formed within, and surrounded by, an uppermost portion of the first conductive region but is not formed in a lowermost portion of the first conductive region. |
| FILED | Friday, February 10, 2012 |
| APPL NO | 13/371241 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/59 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580661 | Wang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Qi Wang (Littleton, Colorado) |
| ASSIGNEE(S) | U.S. Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Qi Wang (Littleton, Colorado) |
| ABSTRACT | A method for hydrogenating poly-si. Poly-si is placed into the interior of a chamber. A filament is placed into the interior of a chamber. The base pressure of the interior of the chamber is evacuated, preferably to 10−6 Torr or less. The poly-si is heated for a predetermined poly-si heating time. The filament is heated by providing an electrical power to the filament. Hydrogen is supplied into the pressurized interior of the chamber comprising the heated poly-si and the heated filament. Atomic hydrogen is produced by the filament at a rate whereby the atomic hydrogen surface density at the poly-si is less than the poly-si surface density. Preferably, the poly-si is covered from the atomic hydrogen produced by the heated filament for a first predetermined covering time. Preferably, the poly-si is then uncovered from the atomic hydrogen produced by the heated filament for a first hydrogenation time. |
| FILED | Wednesday, August 24, 2011 |
| APPL NO | 13/216304 |
| ART UNIT | 2823 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/488 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580845 | Sessler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jonathan L. Sessler (Austin, Texas); Patricia J. Pantos (Providence, Rhode Island) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jonathan L. Sessler (Austin, Texas); Patricia J. Pantos (Providence, Rhode Island) |
| ABSTRACT | Disclosed are functionalized expanded porphyrins that can be used as spectrometric sensors for high-valent actinide cations. The disclosed functionalized expanded porphyrins have the advantage over unfunctionalized systems in that they can be immobilized via covalent attachment to a solid support comprising an inorganic or organic polymer or other common substrates. Substrates comprising the disclosed functionalized expanded porphyrins are also disclosed. Further, disclosed are methods of making the disclosed compounds (immobilized and free), methods of using them as sensors to detect high valent actinides, devices that comprise the disclosed compounds, and kits. |
| FILED | Monday, June 23, 2008 |
| APPL NO | 12/664524 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/422 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580923 | Stupp et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Samuel I. Stupp (Chicago, Illinois); Jack J. J. M. Donners (Evanston, Illinois); Gabriel A. Silva (Chicago, Illinois); Heather A. Behanna (Chicago, Illinois); Shawn G. Anthony (New Stanton, Pennsylvania) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Samuel I. Stupp (Chicago, Illinois); Jack J. J. M. Donners (Evanston, Illinois); Gabriel A. Silva (Chicago, Illinois); Heather A. Behanna (Chicago, Illinois); Shawn G. Anthony (New Stanton, Pennsylvania) |
| ABSTRACT | Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related methods of use. |
| FILED | Monday, March 19, 2012 |
| APPL NO | 13/423310 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/326 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581042 | Morant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marc D. Morant (Copenhagen, Denmark); Shamkant Patkar (Lyngby, Denmark); Hanshu Ding (Davis, California) |
| ASSIGNEE(S) | Novozymes A/S (Bagsvaerd, Denmark); Novozymes, Inc. (Davis, California) |
| INVENTOR(S) | Marc D. Morant (Copenhagen, Denmark); Shamkant Patkar (Lyngby, Denmark); Hanshu Ding (Davis, California) |
| ABSTRACT | The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. |
| FILED | Thursday, June 30, 2011 |
| APPL NO | 13/174391 |
| ART UNIT | 1638 — Organic Chemistry |
| CURRENT CPC | Multicellular living organisms and unmodified parts thereof and related processes 8/284 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581195 | DiPrete et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David P. DiPrete (Evans, Georgia); Tad Whiteside (Aiken, South Carolina); Donald J. Pak (Martinez, Georgia); Cecilia C. DiPrete (Evans, Georgia) |
| ASSIGNEE(S) | Savannah River Nuclear Solutions, LLC (Aiken, South Carolina) |
| INVENTOR(S) | David P. DiPrete (Evans, Georgia); Tad Whiteside (Aiken, South Carolina); Donald J. Pak (Martinez, Georgia); Cecilia C. DiPrete (Evans, Georgia) |
| ABSTRACT | A system for assaying radiation includes a sample holder configured to hold a liquid scintillation solution. A photomultiplier receives light from the liquid scintillation solution and generates a signal reflective of the light. A control circuit biases the photomultiplier and receives the signal from the photomultiplier reflective of the light. A light impermeable casing surrounds the sample holder, photomultiplier, and control circuit. A method for assaying radiation includes placing a sample in a liquid scintillation solution, placing the liquid scintillation solution in a sample holder, and placing the sample holder inside a light impermeable casing. The method further includes positioning a photomultiplier inside the light impermeable casing and supplying power to a control circuit inside the light impermeable casing. |
| FILED | Monday, November 21, 2011 |
| APPL NO | 13/301328 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Radiant energy 250/361.R00 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581272 | Russell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas P. Russell (Amherst, Massachusetts); Soojin Park (Amherst, Massachusetts); Ting Xu (Berkeley, California) |
| ASSIGNEE(S) | The University of Massachusetts (Boston, Massachusetts); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Thomas P. Russell (Amherst, Massachusetts); Soojin Park (Amherst, Massachusetts); Ting Xu (Berkeley, California) |
| ABSTRACT | A nanopatterned surface is prepared by forming a block copolymer film on a miscut crystalline substrate, annealing the block copolymer film, then reconstructing the surface of the annealed block copolymer film. The method creates a well-ordered array of voids in the block copolymer film that is maintained over a large area. The nanopatterned block copolymer films can be used in a variety of different applications, including the fabrication of high density data storage media. |
| FILED | Tuesday, May 01, 2012 |
| APPL NO | 13/461175 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/89 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581463 | Post |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Richard F. Post (Walnut Creek, California) |
| ASSIGNEE(S) | Lawrence Livermore National Laboratory, LLC (Livermore, California) |
| INVENTOR(S) | Richard F. Post (Walnut Creek, California) |
| ABSTRACT | A compact magnetic bearing element is provided which is made of permanent magnet discs configured to be capable of the adjustment of the bearing stiffness and levitation force over a wide range. |
| FILED | Wednesday, June 01, 2011 |
| APPL NO | 13/150467 |
| ART UNIT | 2834 — Electrical Circuits and Systems |
| CURRENT CPC | Electrical generator or motor structure 310/90.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581526 | Hofler |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alicia Hofler (Newport News, Virginia) |
| ASSIGNEE(S) | Jefferson Science Associates, LLC (Newport News, Virginia) |
| INVENTOR(S) | Alicia Hofler (Newport News, Virginia) |
| ABSTRACT | A design for an RF electron gun having a gun cavity utilizing an unbalanced electric field arrangement. Essentially, the electric field in the first (partial) cell has higher field strength than the electric field in the second (full) cell of the electron gun. The accompanying method discloses the use of the unbalanced field arrangement in the operation of an RF electron gun in order to accelerate an electron beam. |
| FILED | Saturday, August 28, 2010 |
| APPL NO | 12/807136 |
| ART UNIT | 2821 — Electrical Circuits and Systems |
| CURRENT CPC | Electric lamp and discharge devices: Systems 315/506 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581584 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mukesh Sharma (Tallahassee, Florida); Myunggi Yi (Busan, South Korea); Hao Dong (Tallahassee, Florida); Huajun Qin (Tallahassee, Florida); David D. Busath (Orem, Utah); Huan-Xiang Zhou (Tallahassee, Florida); Timothy A. Cross (Tallahassee, Florida) |
| ASSIGNEE(S) | Florida State University Research Foundation (Tallahassee, Florida) |
| INVENTOR(S) | Mukesh Sharma (Tallahassee, Florida); Myunggi Yi (Busan, South Korea); Hao Dong (Tallahassee, Florida); Huajun Qin (Tallahassee, Florida); David D. Busath (Orem, Utah); Huan-Xiang Zhou (Tallahassee, Florida); Timothy A. Cross (Tallahassee, Florida) |
| ABSTRACT | The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance. |
| FILED | Thursday, May 26, 2011 |
| APPL NO | 13/067351 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/309 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581587 | Walsh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David O. Walsh (Mukilteo, Washington); Elliot D. Grunewald (Seattle, Washington) |
| ASSIGNEE(S) | Vista Clara Inc. (Mukilteo, Washington) |
| INVENTOR(S) | David O. Walsh (Mukilteo, Washington); Elliot D. Grunewald (Seattle, Washington) |
| ABSTRACT | Technologies applicable to SNMR pulse sequence phase cycling are disclosed, including SNMR acquisition apparatus and methods, SNMR processing apparatus and methods, and combinations thereof. SNMR acquisition may include transmitting two or more SNMR pulse sequences and applying a phase shift to a pulse in at least one of the pulse sequences, according to any of a variety of phase cycling techniques. SNMR processing may include combining SNMR from a plurality of pulse sequences comprising pulses of different phases, so that desired signals are preserved and undesired signals are canceled. |
| FILED | Tuesday, May 10, 2011 |
| APPL NO | 13/104721 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/318 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582092 | Yellowhair et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Julius E. Yellowhair (Albuquerque, New Mexico); Clifford Kuofei Ho (Albuquerque, New Mexico); Richard B. Diver (Albuquerque, New Mexico); Timothy A. Moss (Albuquerque, New Mexico) |
| ASSIGNEE(S) | Sandia Corporation (Albuquerque, New Mexico) |
| INVENTOR(S) | Julius E. Yellowhair (Albuquerque, New Mexico); Clifford Kuofei Ho (Albuquerque, New Mexico); Richard B. Diver (Albuquerque, New Mexico); Timothy A. Moss (Albuquerque, New Mexico) |
| ABSTRACT | Various technologies pertaining to aligning and focusing mirrored facets of a heliostat are described herein. Updating alignment and/or focus of mirrored facets is undertaken through generation of a theoretical image, wherein the theoretical image is indicative of a reflection of the target via the mirrored facets when the mirrored facets are properly aligned. This theoretical image includes reference points that are overlaid on an image of the target as reflected by the mirrored facets of the heliostat. A technician adjusts alignment/focus of a mirrored facet by causing reflected reference markings to become aligned with the reference points in the theoretical image. |
| FILED | Tuesday, April 12, 2011 |
| APPL NO | 13/085118 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/138 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582712 | Karev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alexander Ivanovich Karev (Moscow, Russian Federation); Valery Georgievich Raevsky (Moscow, Russian Federation); Leonid Zavenovich Dzhilavyan (Moscow, Russian Federation); Louis Joseph Brothers (Union, Kentucky); Larry K. Wilhide (Newville, Pennsylvania) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC. (Livermore, California) |
| INVENTOR(S) | Alexander Ivanovich Karev (Moscow, Russian Federation); Valery Georgievich Raevsky (Moscow, Russian Federation); Leonid Zavenovich Dzhilavyan (Moscow, Russian Federation); Louis Joseph Brothers (Union, Kentucky); Larry K. Wilhide (Newville, Pennsylvania) |
| ABSTRACT | Methods for detecting and identifying carbon- and/or nitrogen-containing materials are disclosed. The methods may comprise detection of photo-nuclear reaction products of nitrogen and carbon to detect and identify the carbon- and/or nitrogen-containing materials. |
| FILED | Wednesday, October 05, 2011 |
| APPL NO | 13/253927 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Induced nuclear reactions: Processes, systems, and elements 376/157 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582931 | Vawter |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | G. Allen Vawter (Corrales, New Mexico) |
| ASSIGNEE(S) | Sandia Corporation (Albuquerque, New Mexico) |
| INVENTOR(S) | G. Allen Vawter (Corrales, New Mexico) |
| ABSTRACT | An optical XOR gate is formed as a photonic integrated circuit (PIC) from two sets of optical waveguide devices on a substrate, with each set of the optical waveguide devices including an electroabsorption modulator electrically connected in series with a waveguide photodetector. The optical XOR gate utilizes two digital optical inputs to generate an XOR function digital optical output. The optical XOR gate can be formed from III-V compound semiconductor layers which are epitaxially deposited on a III-V compound semiconductor substrate, and operates at a wavelength in the range of 0.8-2.0 μm. |
| FILED | Monday, December 20, 2010 |
| APPL NO | 12/973470 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical waveguides 385/14 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582936 | Ruggiero et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Anthony J. Ruggiero (Livermore, California); Donald A. Masquelier (Tracy, California); Jeffery B. Cooke (Knightsen, California); Jeffery S. Kallman (Plesanton, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Anthony J. Ruggiero (Livermore, California); Donald A. Masquelier (Tracy, California); Jeffery B. Cooke (Knightsen, California); Jeffery S. Kallman (Plesanton, California) |
| ABSTRACT | Techniques for combining initially separate single mode and multimode optical beams into a single “Dual Mode” fiber optic have been developed. Bi-directional propagation of two beams that are differentiated only by their mode profiles (i.e., wavefront conditions) is provided. The beams can be different wavelengths and or contain different modulation information but still share a common aperture. This method allows the use of conventional micro optics and hybrid photonic packaging techniques to produce small rugged packages suitable for use in industrial or military environments. |
| FILED | Thursday, March 24, 2011 |
| APPL NO | 13/071382 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical waveguides 385/39 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08584141 | Archer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Charles J. Archer (Rochester, Minnesota); Michael A. Blocksome (Rochester, Minnesota); Joseph D. Ratterman (Rochester, Minnesota); Brian E. Smith (Rochester, Minnesota) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Charles J. Archer (Rochester, Minnesota); Michael A. Blocksome (Rochester, Minnesota); Joseph D. Ratterman (Rochester, Minnesota); Brian E. Smith (Rochester, Minnesota) |
| ABSTRACT | Data communications in a parallel active messaging interface (‘PAMI’) of a parallel computer composed of compute nodes that execute a parallel application, each compute node including application processors that execute the parallel application and at least one management processor dedicated to gathering information regarding data communications. The PAMI is composed of data communications endpoints, each endpoint composed of a specification of data communications parameters for a thread of execution on a compute node, including specifications of a client, a context, and a task, the compute nodes and the endpoints coupled for data communications through the PAMI and through data communications resources. Embodiments function by gathering call site statistics describing data communications resulting from execution of data communications instructions and identifying in dependence upon the call cite statistics a data communications algorithm for use in executing a data communications instruction at a call site in the parallel application. |
| FILED | Monday, January 17, 2011 |
| APPL NO | 13/007860 |
| ART UNIT | 2196 — Interprocess Communication and Software Development |
| CURRENT CPC | Electrical computers and digital processing systems: Interprogram communication or interprocess communication 719/313 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 08578708 | Bollinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Benjamin R. Bollinger (Windsor, Vermont); Lee Doyle (Lebanon, New Hampshire); Michael Neil Scott (West Labanon, New Hampshire); Troy O. McBride (Norwich, Vermont); Andrew Shang (Lebanon, New Hampshire) |
| ASSIGNEE(S) | SustainX, Inc. (Seabrook, New Hampshire) |
| INVENTOR(S) | Benjamin R. Bollinger (Windsor, Vermont); Lee Doyle (Lebanon, New Hampshire); Michael Neil Scott (West Labanon, New Hampshire); Troy O. McBride (Norwich, Vermont); Andrew Shang (Lebanon, New Hampshire) |
| ABSTRACT | In various embodiments, compressed-gas energy storage and recovery systems feature one or more valves, which may be disposed within end caps of cylinder assemblies in which gas is expanded and/or compressed, for admitting fluid to and/or exhausting fluid from the cylinder assembly. |
| FILED | Wednesday, November 30, 2011 |
| APPL NO | 13/307163 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Power plants 060/398 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579117 | Loutherback et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kevin Loutherback (Princeton, New Jersey); James C. Sturm (Princeton, New Jersey); Robert Austin (Princeton, New Jersey); Keith Morton (Princeton, New Jersey); Jason Puchalla (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Kevin Loutherback (Princeton, New Jersey); James C. Sturm (Princeton, New Jersey); Robert Austin (Princeton, New Jersey); Keith Morton (Princeton, New Jersey); Jason Puchalla (Princeton, New Jersey) |
| ABSTRACT | The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ. |
| FILED | Friday, July 24, 2009 |
| APPL NO | 12/509175 |
| ART UNIT | 3653 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Classifying, separating, and assorting solids 29/210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08579842 | Majidi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carmel S. Majidi (Pittsburgh, Pennsylvania); Robert J. Wood (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Carmel S. Majidi (Pittsburgh, Pennsylvania); Robert J. Wood (Cambridge, Massachusetts) |
| ABSTRACT | A method and system are provided for that allow for varying stiffness of a system by applying a low magnetic field to magnetorheological (MR) fluid in the system. The method and system include exposed patterns on facing surfaces of sliding structures. The facing patterns contain MR fluid. When a low to moderate magnetic field is applied to the MR fluid, the patterns are magnetically attracted to MR domains confined to the opposing surface, thus requiring additional force to slide the structures past each other. |
| FILED | Friday, November 12, 2010 |
| APPL NO | 12/945029 |
| ART UNIT | 3772 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Surgery: Splint, brace, or bandage 62/5 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580099 | Koley |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Goutam Koley (North Augusta, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Goutam Koley (North Augusta, South Carolina) |
| ABSTRACT | Sensor are generally provided that include a layer of silicon oxide on a portion of a n+ layer to form an uneven surface where the layer of silicon oxide defines a thicker region than an exposed portion of the n+ layer. First and second metal contacts can be on the layer of silicon oxide, with first and second nanowires extending respectively from a first base on the first metal contact and a second base on the second metal contact. The first nanowire and the second nanowire are connected together at an apex to form a v-shaped nanocantilever, wherein the apex is positioned over the exposed n+ layer, and wherein the nanowires comprise indium and nitrogen. Methods of fabricating such sensors, along with methods of their use, are also generally provided. |
| FILED | Tuesday, September 20, 2011 |
| APPL NO | 13/237424 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Chemistry: Electrical and wave energy 24/667 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580144 | Chien et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Liang-Chy Chien (Hudson, Ohio); Jeoung Yeon Hwang (Dajeon, South Korea); Jenny-Marie Wong (Tonawanda, New York) |
| ASSIGNEE(S) | Kent State University (Kent, Ohio) |
| INVENTOR(S) | Liang-Chy Chien (Hudson, Ohio); Jeoung Yeon Hwang (Dajeon, South Korea); Jenny-Marie Wong (Tonawanda, New York) |
| ABSTRACT | A composition including nanocomposites formed from blue phase liquid crystals that are stabilized with dopants and nanorods such as metallic nanorods and/or carbon nanotubes. Devices including the compositions are disclosed that provide increases temperature ranges as well as reduction in threshold voltage and turn on voltage, in addition to the inherent blue phase liquid crystal properties of sub-millisecond response time in the field induced Kerr effect. |
| FILED | Friday, April 06, 2012 |
| APPL NO | 13/441027 |
| ART UNIT | 1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Compositions 252/299.10 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580290 | DeAngelis |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paul L. DeAngelis (Edmond, Oklahoma) |
| ASSIGNEE(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| INVENTOR(S) | Paul L. DeAngelis (Edmond, Oklahoma) |
| ABSTRACT | The presently claimed and disclosed invention relates to biomaterial compositions that include an isolated heparosan polymer. The presently claimed and disclosed invention also relates to kits containing such biomaterial compositions, as well as to methods of producing such biomaterial compositions. The presently claimed and disclosed invention further relates to methods of using such biomaterial compositions as surface coatings for implants as well as for augmenting tissues. |
| FILED | Monday, March 31, 2008 |
| APPL NO | 12/080060 |
| ART UNIT | 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/423 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580291 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hoon Choi (Bryn Mawr, Pennsylvania); I. Wei Chen (Swarthmore, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Hoon Choi (Bryn Mawr, Pennsylvania); I. Wei Chen (Swarthmore, Pennsylvania) |
| ABSTRACT | Provided are fibrous composites prepared by methods of the present invention, comprising oxides and biodegradable polymers, in which the fibers are made of aerogel-like oxide materials having nanometer-sized pores. The fibrous composition advantageously has, at least, the following characteristics: (i) a very high nanoporous surface area, which also permits nucleation of crystallites; (ii) mesoporous/macroporous interspacial networks between the fibers, providing high bioactivity and a high transport rate; (iii) macropores for natural bone-like tissue growth; (iv) good mechanical properties for handling and for implant support; and (v) biodegradability for implant dissolution and time-variable mechanical properties. Further provided are methods for using the bioactive biodegradable fibrous composites as osteogenic composite materials for tissue engineering, tissue re-growth, bone implants, and bone repair, and/or for the delivery of drugs or therapeutic compounds. |
| FILED | Friday, March 14, 2003 |
| APPL NO | 10/507059 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/426 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580924 | Jin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hyoung-Joon Jin (Yangcheon-Gu, South Korea); Jae-Hyung Park (Decatur, Georgia); Regina Valluzzi (Medford, Massachusetts) |
| ASSIGNEE(S) | Trustees of Tufts College (Boston, Massachusetts) |
| INVENTOR(S) | Hyoung-Joon Jin (Yangcheon-Gu, South Korea); Jae-Hyung Park (Decatur, Georgia); Regina Valluzzi (Medford, Massachusetts) |
| ABSTRACT | One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method. |
| FILED | Thursday, August 06, 2009 |
| APPL NO | 12/536793 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/353 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580969 | Myers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Andrew G. Myers (Boston, Massachusetts); Jason D. Brubaker (Cheshire, Connecticut) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Andrew G. Myers (Boston, Massachusetts); Jason D. Brubaker (Cheshire, Connecticut) |
| ABSTRACT | The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides a more efficient route for preparing the enone intermediate. |
| FILED | Friday, September 14, 2012 |
| APPL NO | 13/616667 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Organic compounds 548/243 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580970 | Sharpless et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | K. Barry Sharpless (La Jolla, California); Valery Fokin (Oceanside, California); Vsevold V. Rostovtsev (Wilmington, Delaware); Luke Green (Basel, Switzerland); Fahmi Himo (Solna, Sweden) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | K. Barry Sharpless (La Jolla, California); Valery Fokin (Oceanside, California); Vsevold V. Rostovtsev (Wilmington, Delaware); Luke Green (Basel, Switzerland); Fahmi Himo (Solna, Sweden) |
| ABSTRACT | A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine. |
| FILED | Monday, March 05, 2012 |
| APPL NO | 13/412270 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Organic compounds 548/255 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581272 | Russell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas P. Russell (Amherst, Massachusetts); Soojin Park (Amherst, Massachusetts); Ting Xu (Berkeley, California) |
| ASSIGNEE(S) | The University of Massachusetts (Boston, Massachusetts); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Thomas P. Russell (Amherst, Massachusetts); Soojin Park (Amherst, Massachusetts); Ting Xu (Berkeley, California) |
| ABSTRACT | A nanopatterned surface is prepared by forming a block copolymer film on a miscut crystalline substrate, annealing the block copolymer film, then reconstructing the surface of the annealed block copolymer film. The method creates a well-ordered array of voids in the block copolymer film that is maintained over a large area. The nanopatterned block copolymer films can be used in a variety of different applications, including the fabrication of high density data storage media. |
| FILED | Tuesday, May 01, 2012 |
| APPL NO | 13/461175 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/89 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581584 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mukesh Sharma (Tallahassee, Florida); Myunggi Yi (Busan, South Korea); Hao Dong (Tallahassee, Florida); Huajun Qin (Tallahassee, Florida); David D. Busath (Orem, Utah); Huan-Xiang Zhou (Tallahassee, Florida); Timothy A. Cross (Tallahassee, Florida) |
| ASSIGNEE(S) | Florida State University Research Foundation (Tallahassee, Florida) |
| INVENTOR(S) | Mukesh Sharma (Tallahassee, Florida); Myunggi Yi (Busan, South Korea); Hao Dong (Tallahassee, Florida); Huajun Qin (Tallahassee, Florida); David D. Busath (Orem, Utah); Huan-Xiang Zhou (Tallahassee, Florida); Timothy A. Cross (Tallahassee, Florida) |
| ABSTRACT | The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance. |
| FILED | Thursday, May 26, 2011 |
| APPL NO | 13/067351 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/309 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581605 | White et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Henry S White (Salt Lake City, Utah); Ryan J White (Salt Lake City, Utah); Eric N Ervin (Salt Lake City, Utah) |
| ASSIGNEE(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| INVENTOR(S) | Henry S White (Salt Lake City, Utah); Ryan J White (Salt Lake City, Utah); Eric N Ervin (Salt Lake City, Utah) |
| ABSTRACT | A nanopore device includes a membrane having a nanopore extending there through forming a channel from a first side of the membrane to a second side of the membrane. The surface of the channel and first side of the membrane are modified with a hydrophobic coating. A first lipid monolayer is deposited on the first side of the membrane, and a second lipid monolayer is deposited on the second side of the membrane, wherein the hydrophobic coating causes spontaneous generation of a lipid bilayer across the nanopore orifice. Sensing entities, such as a protein ion channel, can be inserted and removed from the bilayer by adjusting transmembrane pressure, and adapter molecules can be electrostatically trapped in the ion channel by applying high transmembrane voltages, while resistance or current flow through the sensing entity can be measured electrically. |
| FILED | Wednesday, June 30, 2010 |
| APPL NO | 12/827503 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/693 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582096 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zhongping Chen (Irvine, California); Gangjun Liu (Irvine, California); Mihael Balu (Newport Beach, California); Bruce Tromberg (Irvine, California); Eric Olaf Potma (Irvine, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zhongping Chen (Irvine, California); Gangjun Liu (Irvine, California); Mihael Balu (Newport Beach, California); Bruce Tromberg (Irvine, California); Eric Olaf Potma (Irvine, California) |
| ABSTRACT | A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging. |
| FILED | Wednesday, December 15, 2010 |
| APPL NO | 12/969295 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/301 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583291 | Beal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jacob S. Beal (Somerville, Massachusetts); Jonathan R. Bachrach (Berkeley, California) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jacob S. Beal (Somerville, Massachusetts); Jonathan R. Bachrach (Berkeley, California) |
| ABSTRACT | To manage energy demands of a plurality of appliances, a meter controller apparatus receives a first message from a first appliance controller apparatus coupled to a first appliance of the plurality of appliances. The first message comprises first information regarding a first power demand of the first appliance and a first demand category associated with the first appliance, wherein the first demand category is one of a plurality of demand categories. The meter controller apparatus computes an updated meter controller model for the plurality of appliances based at least in part on the first message received from the first appliance controller apparatus and a present meter controller model for the plurality of appliances. |
| FILED | Thursday, September 13, 2012 |
| APPL NO | 13/614753 |
| ART UNIT | 2121 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Generic control systems or specific applications 7/291 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583565 | Shoureshi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rahmat A. Shoureshi (Golden, Colorado); Christopher Aasted (Broomfield, Colorado) |
| ASSIGNEE(S) | Colorado Seminary, which owns and operates the University of Denver (Denver, Colorado) |
| INVENTOR(S) | Rahmat A. Shoureshi (Golden, Colorado); Christopher Aasted (Broomfield, Colorado) |
| ABSTRACT | Methods and systems for controlling a prosthesis using a brain imager that images a localized portion of the brain are provided according to one embodiment of the invention. For example, the brain imager can provide motor cortex activation data using near infrared imaging techniques and EEG techniques among others. EEG and near infrared signals can be correlated with brain activity related to limbic control and may be provided to a neural network, for example, a fuzzy neural network that maps brain activity data to limbic control data. The limbic control data may then be used to control a prosthetic limb. Other embodiments of the invention include fiber optics that provide light to and receive light from the surface of the scalp through hair. |
| FILED | Thursday, August 05, 2010 |
| APPL NO | 12/850964 |
| ART UNIT | 2129 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Artificial intelligence 76/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583598 | Shaull et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ross Shaull (Chelmsford, Massachusetts); Liuba Shrira (Brookline, Massachusetts); Hao Xu (Lexington, Massachusetts) |
| ASSIGNEE(S) | Brandeis University (Waltham, Massachusetts) |
| INVENTOR(S) | Ross Shaull (Chelmsford, Massachusetts); Liuba Shrira (Brookline, Massachusetts); Hao Xu (Lexington, Massachusetts) |
| ABSTRACT | Decreasing disk costs make it possible to take frequent snapshots of past storage system states and retain them for a long duration. Existing snapshot approaches offer no satisfactory solution to long-lived snapshots. Split snapshots are an approach that is promising because it does not disrupt the current state storage system in either the short or the long run. An unsolved problem has been how to maintain an efficient access method for long-lived split snapshots without imposing undesirable overhead on the storage system. Skippy is a new approach that inexpensively indexes long-lived snapshots in parallel with snapshot creation. An embodiment of Skippy uses append-only index data structures to optimize writes while simultaneously providing low-latency snapshot lookup. Performance evaluations of Skippy indicate that this new approach is effective and efficient. It provides close-to-optimal access to long-lived snapshots while incurring a minimal impact on the current-state storage system. |
| FILED | Thursday, May 29, 2008 |
| APPL NO | 12/601948 |
| ART UNIT | 2167 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/639 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583625 | Peterson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Larry L. Peterson (Princeton, New Jersey); Vivek S. Pai (Princeton, New Jersey); Sunghwan Ihm (Sunnyvale, California); Anirudh Badam (Princeton, New Jersey); KyoungSoo Park (Daejeon, South Korea) |
| ASSIGNEE(S) | The Trustees of Princeton (University, New Jersey) |
| INVENTOR(S) | Larry L. Peterson (Princeton, New Jersey); Vivek S. Pai (Princeton, New Jersey); Sunghwan Ihm (Sunnyvale, California); Anirudh Badam (Princeton, New Jersey); KyoungSoo Park (Daejeon, South Korea) |
| ABSTRACT | The illustrative embodiments described herein are directed to a system, methods, and computer program product, for network acceleration and efficient indexing for caching file systems. For example, the disclosed embodiments achieve (1) high compression rate, (2) low disk seeks, and (3) low memory pressure using by introducing novel features such as, but not limited to, multi-resolution chunking and intelligent load shedding. In addition, the disclosed embodiments introduces a family of HashCache policies that enable large size web caching with little or no use of main memory. |
| FILED | Saturday, March 20, 2010 |
| APPL NO | 13/257736 |
| ART UNIT | 2163 — Data Bases & File Management |
| CURRENT CPC | Data processing: Database and file management or data structures 77/713 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08584099 | Abi-Antoun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marwan Elia Abi-Antoun (Pittsburgh, Pennsylvania); Jonathan Erik Aldrich (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Marwan Elia Abi-Antoun (Pittsburgh, Pennsylvania); Jonathan Erik Aldrich (Pittsburgh, Pennsylvania) |
| ABSTRACT | Apparatuses and methods for producing run-time architectures of computer program modules. One embodiment includes creating an abstract graph from the computer program module and from containment information corresponding to the computer program module, wherein the abstract graph has nodes including types and objects, and wherein the abstract graph relates an object to a type, and wherein for a specific object the abstract graph relates the specific object to a type containing the specific object; and creating a runtime graph from the abstract graph, wherein the runtime graph is a representation of the true runtime object graph, wherein the runtime graph represents containment information such that, for a specific object, the runtime graph relates the specific object to another object that contains the specific object. |
| FILED | Friday, June 27, 2008 |
| APPL NO | 12/215476 |
| ART UNIT | 2197 — Computer Architecture and I/O |
| CURRENT CPC | Data processing: Software development, installation, and management 717/131 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 08578757 | Ren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fan Ren (Gainesville, Florida); Jenshan Lin (Gainesville, Florida); David Paul Norton (Gainesville, Florida); Stephen John Pearton (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| INVENTOR(S) | Fan Ren (Gainesville, Florida); Jenshan Lin (Gainesville, Florida); David Paul Norton (Gainesville, Florida); Stephen John Pearton (Gainesville, Florida) |
| ABSTRACT | Exemplary embodiments provide a self-powered wireless gas sensor system and a method for gas sensing using the system. The system can be used to detect and constantly track a presence of various gases including hydrogen, ozone and/or any hydrocarbon gas, and remotely transmit the sensing signal. The system can include a low power gas sensor that consumes less than about 30 nano-watts of power. As a result, the system can detect the presence of hydrogen at about 10 ppm. The sensor can also provide a fast response time of about 1-2 seconds. In various embodiments, the system can be physically small and packaged with all components assembled as a single compact unit. |
| FILED | Thursday, October 05, 2006 |
| APPL NO | 12/443297 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/31.50 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08578807 | Kunz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert F. Kunz (State College, Pennsylvania); Richard B. Medvitz (State College, Pennsylvania); Matthew John Hill (Keller, Texas) |
| ASSIGNEE(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| INVENTOR(S) | Robert F. Kunz (State College, Pennsylvania); Richard B. Medvitz (State College, Pennsylvania); Matthew John Hill (Keller, Texas) |
| ABSTRACT | A gear and drive system utilizing the gear include teeth. Each of the teeth has a first side and a second side opposite the first side that extends from a body of the gear. For each tooth of the gear, a first extended portion is attached to the first side of the tooth to divert flow of fluid adjacent to the body of the gear to reduce windage losses that occur when the gear rotates. The gear may be utilized in drive systems that may have high rotational speeds, such as speeds where the tip velocities are greater than or equal to about 68 m/s. Some embodiments of the gear may also utilize teeth that also have second extended portions attached to the second sides of the teeth to divert flow of fluid adjacent to the body of the gear to reduce windage losses that occur when the gear rotates. |
| FILED | Wednesday, April 18, 2012 |
| APPL NO | 13/449569 |
| ART UNIT | 3658 — Material and Article Handling |
| CURRENT CPC | Machine element or mechanism 074/457 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580546 | Gonda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of the National Aeronautics and Space Administrator (Washington, District of Columbia); Iris Von Gustedt-Gonda (Highlands Ranch, Colorado) |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Steve R. Gonda (Houston, Texas); Robert C. Chang (Philadelphia, Pennsylvania); Binil Starly (Norman, Oklahoma); Christopher Culbertson (Saint George, Kansas); Heidi L. Holtorf (Nederland, Texas); Wei Sun (Cherry Hill, New Jersey); Julia Leslie (Houston, Texas) |
| ABSTRACT | A method for fabricating a micro-organ device comprises providing a microscale support having one or more microfluidic channels and one or more micro-chambers for housing a micro-organ and printing a micro-organ on the microscale support using a cell suspension in a syringe controlled by a computer-aided tissue engineering system, wherein the cell suspension comprises cells suspended in a solution containing a material that functions as a three-dimensional scaffold. The printing is performed with the computer-aided tissue engineering system according to a particular pattern. The micro-organ device comprises at least one micro-chamber each housing a micro-organ; and at least one microfluidic channel connected to the micro-chamber, wherein the micro-organ comprises cells arranged in a configuration that includes microscale spacing between portions of the cells to facilitate diffusion exchange between the cells and a medium supplied from the at least one microfluidic channel. |
| FILED | Thursday, November 29, 2012 |
| APPL NO | 13/688982 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/174 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580924 | Jin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hyoung-Joon Jin (Yangcheon-Gu, South Korea); Jae-Hyung Park (Decatur, Georgia); Regina Valluzzi (Medford, Massachusetts) |
| ASSIGNEE(S) | Trustees of Tufts College (Boston, Massachusetts) |
| INVENTOR(S) | Hyoung-Joon Jin (Yangcheon-Gu, South Korea); Jae-Hyung Park (Decatur, Georgia); Regina Valluzzi (Medford, Massachusetts) |
| ABSTRACT | One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method. |
| FILED | Thursday, August 06, 2009 |
| APPL NO | 12/536793 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/353 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581452 | Roopnarine |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Roopnarine (New York, New York) |
| ASSIGNEE(S) | Honeybee Robotics Ltd. (New York, New York) |
| INVENTOR(S) | Roopnarine (New York, New York) |
| ABSTRACT | A high temperature motor has a stator with poles formed by wire windings, and a rotor with magnetic poles on a rotor shaft positioned coaxially within the stator. The stator and rotor are built up from stacks of magnetic-alloy laminations. The stator windings are made of high temperature magnet wire insulated with a vitreous enamel film, and the wire windings are bonded together with ceramic binder. A thin-walled cylinder is positioned coaxially between the rotor and the stator to prevent debris from the stator windings from reaching the rotor. The stator windings are wound on wire spools made of ceramic, thereby avoiding need for mica insulation and epoxy/adhesive. The stator and rotor are encased in a stator housing with rear and front end caps, and rear and front bearings for the rotor shaft are mounted on external sides of the end caps to keep debris from the motor migrating into the bearings' races. |
| FILED | Tuesday, July 26, 2011 |
| APPL NO | 13/190647 |
| ART UNIT | 2834 — Electrical Circuits and Systems |
| CURRENT CPC | Electrical generator or motor structure 310/45 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08582805 | Monacos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Steve P. Monacos (Altadena, California); Michael E. Hoenk (Valencia, California); Shouleh Nikzad (Valencia, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Steve P. Monacos (Altadena, California); Michael E. Hoenk (Valencia, California); Shouleh Nikzad (Valencia, California) |
| ABSTRACT | Apparatuses and methods are disclosed that create a synthetic fovea in order to identify and highlight interesting portions of an image for further processing and rapid response. Synthetic foveal imaging implements a parallel processing architecture that uses reprogrammable logic to implement embedded, distributed, real-time foveal image processing from different sensor types while simultaneously allowing for lossless storage and retrieval of raw image data. Real-time, distributed, adaptive processing of multi-tap image sensors with coordinated processing hardware used for each output tap is enabled. In mosaic focal planes, a parallel-processing network can be implemented that treats the mosaic focal plane as a single ensemble rather than a set of isolated sensors. Various applications are enabled for imaging and robotic vision where processing and responding to enormous amounts of data quickly and efficiently is important. |
| FILED | Wednesday, November 05, 2008 |
| APPL NO | 12/265387 |
| ART UNIT | 2669 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Image analysis 382/103 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08584099 | Abi-Antoun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marwan Elia Abi-Antoun (Pittsburgh, Pennsylvania); Jonathan Erik Aldrich (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Marwan Elia Abi-Antoun (Pittsburgh, Pennsylvania); Jonathan Erik Aldrich (Pittsburgh, Pennsylvania) |
| ABSTRACT | Apparatuses and methods for producing run-time architectures of computer program modules. One embodiment includes creating an abstract graph from the computer program module and from containment information corresponding to the computer program module, wherein the abstract graph has nodes including types and objects, and wherein the abstract graph relates an object to a type, and wherein for a specific object the abstract graph relates the specific object to a type containing the specific object; and creating a runtime graph from the abstract graph, wherein the runtime graph is a representation of the true runtime object graph, wherein the runtime graph represents containment information such that, for a specific object, the runtime graph relates the specific object to another object that contains the specific object. |
| FILED | Friday, June 27, 2008 |
| APPL NO | 12/215476 |
| ART UNIT | 2197 — Computer Architecture and I/O |
| CURRENT CPC | Data processing: Software development, installation, and management 717/131 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 08581782 | Hoover |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | On Target Enterprises, Inc. (Matheson, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Hoover (Matheson, Colorado) |
| ABSTRACT | Provided is a non-transitory machine readable medium on which is stored a computer program including instructions to adapt a computer system having at least one processor as a simultaneous radio detection and bearing system, including: an RF conditioning subsystem for connection to a plurality of arrays of Frequency Range signal receiving channels, the RF conditioning subsystem operable to combine the signals from the arrays as a first internal data stream; and a coherent multi-channel digitizer subsystem coupled to the RF conditioning system, the coherent multi-channel digitizer subsystem operable to generate a time domain snapshot of the first internal data stream. The computer instructions further adapting the processor to transform the time domain snapshot to a frequency spectrum and identify at least one signal above a threshold at a determined frequency, determine the bearing of the signal, and provide the determined frequency of a selected identified signal to an audio recording subsystem, the audio subsystem contemporaneously recording the selected signal upon the determined frequency. |
| FILED | Tuesday, November 20, 2012 |
| APPL NO | 13/682495 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Communications: Directive radio wave systems and devices 342/442 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08583898 | Greyzck |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Terry D. Greyzck (Eagan, Minnesota) |
| ASSIGNEE(S) | Cray Inc. (Seattle, Washington) |
| INVENTOR(S) | Terry D. Greyzck (Eagan, Minnesota) |
| ABSTRACT | A system and method of compiling program code, wherein the program code includes an operation on an array of data elements stored in memory of a computer system. The program code is scanned for operations that are vectorizable. The vectorizable operations are examined to determine whether they should be executed at least in part in a vector atomic memory operation (AMO) functional unit attached to memory. If so, the compiled code includes vector AMO instructions. |
| FILED | Friday, June 12, 2009 |
| APPL NO | 12/484062 |
| ART UNIT | 2198 — Computer Architecture and I/O |
| CURRENT CPC | Electrical computers and digital processing systems: Processing architectures and instruction processing 712/208 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08584099 | Abi-Antoun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marwan Elia Abi-Antoun (Pittsburgh, Pennsylvania); Jonathan Erik Aldrich (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Marwan Elia Abi-Antoun (Pittsburgh, Pennsylvania); Jonathan Erik Aldrich (Pittsburgh, Pennsylvania) |
| ABSTRACT | Apparatuses and methods for producing run-time architectures of computer program modules. One embodiment includes creating an abstract graph from the computer program module and from containment information corresponding to the computer program module, wherein the abstract graph has nodes including types and objects, and wherein the abstract graph relates an object to a type, and wherein for a specific object the abstract graph relates the specific object to a type containing the specific object; and creating a runtime graph from the abstract graph, wherein the runtime graph is a representation of the true runtime object graph, wherein the runtime graph represents containment information such that, for a specific object, the runtime graph relates the specific object to another object that contains the specific object. |
| FILED | Friday, June 27, 2008 |
| APPL NO | 12/215476 |
| ART UNIT | 2197 — Computer Architecture and I/O |
| CURRENT CPC | Data processing: Software development, installation, and management 717/131 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 08580035 | Bondokov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Crystal IS, Inc. (Green Island, New York) |
| ASSIGNEE(S) | Crystal IS, Inc. (Green Island, New York) |
| INVENTOR(S) | Robert Bondokov (Watervliet, New York); Kenneth E. Morgan (Castleton, New York); Glen A. Slack (Scotia, New York); Leo J. Schowalter (Latham, New York) |
| ABSTRACT | Reducing the microvoid (MV) density in AlN ameliorates numerous problems related to cracking during crystal growth, etch pit generation during the polishing, reduction of the optical transparency in an AlN wafer, and, possibly, growth pit formation during epitaxial growth of AlN and/or AlGaN. This facilitates practical crystal production strategies and the formation of large, bulk AlN crystals with low defect densities—e.g., a dislocation density below 104 cm−2 and an inclusion density below 104 cm−3 and/or a MV density below 104 cm−3. |
| FILED | Thursday, December 06, 2012 |
| APPL NO | 13/706966 |
| ART UNIT | 1714 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor 117/97 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580541 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bin Yang (Richland, Washington); Charles E. Wyman (Riverside, California) |
| ASSIGNEE(S) | The Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Bin Yang (Richland, Washington); Charles E. Wyman (Riverside, California) |
| ABSTRACT | Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment enhances cellulase availability in cellulose conversion and allows for the determination of optimized pretreatment conditions. Additionally, ethanol yields from a Simultaneous Saccharification and Fermentation process are improved 5-25% by treatment with a lignin-blocking polypeptide and/or protein. |
| FILED | Tuesday, December 07, 2010 |
| APPL NO | 12/962366 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/161 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 08579117 | Loutherback et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kevin Loutherback (Princeton, New Jersey); James C. Sturm (Princeton, New Jersey); Robert Austin (Princeton, New Jersey); Keith Morton (Princeton, New Jersey); Jason Puchalla (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Kevin Loutherback (Princeton, New Jersey); James C. Sturm (Princeton, New Jersey); Robert Austin (Princeton, New Jersey); Keith Morton (Princeton, New Jersey); Jason Puchalla (Princeton, New Jersey) |
| ABSTRACT | The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ. |
| FILED | Friday, July 24, 2009 |
| APPL NO | 12/509175 |
| ART UNIT | 3653 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Classifying, separating, and assorting solids 29/210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08580748 | McCoy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sharon L. McCoy (Portland, Oregon); Steven H. Hefeneider (Portland, Oregon) |
| ASSIGNEE(S) | 13Therapeutics, Inc. (Portland, Oregon) |
| INVENTOR(S) | Sharon L. McCoy (Portland, Oregon); Steven H. Hefeneider (Portland, Oregon) |
| ABSTRACT | Peptides for the treatment of inflammation, and therapeutic uses and methods of using the same are disclosed. Peptides including a transducing sequence are effective for inhibiting cytokine activity and TNF-α secretion through interaction with toll-like receptor signaling pathways. Experiments are described illustrating the efficacy of the compounds in treating otitis media, noise-induced hearing loss, age-related hearing loss, and improvement of ordinary hearing. |
| FILED | Thursday, April 05, 2012 |
| APPL NO | 13/440591 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/21.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 08580161 | Remcho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vincent Thomas Remcho (Corvallis, Oregon); Jintana Nammoonnoy (Corvallis, Oregon); Myra Koesdjojo (Corvallis, Oregon) |
| ASSIGNEE(S) | State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Vincent Thomas Remcho (Corvallis, Oregon); Jintana Nammoonnoy (Corvallis, Oregon); Myra Koesdjojo (Corvallis, Oregon) |
| ABSTRACT | Photochromic materials that are useful for a variety of applications, including for making various unit functions of fluidic devices, particularly microfluidic devices, such as microchannels, valves and gates, using spiropyran materials, such as a polymeric composition comprising a spiropyran. In certain disclosed embodiments the spiropyran is admixed with a polymeric material. For example, the spiropyran may be intercalated into a polyalkylene or polyalkylene phthalate. The spiropyran also may be polymerized with at least one additional monomer to form a heteropolymer, such as by polymerization with styrene, styrene derivatives, acrylate and acrylate derivatives. The spiropyran compositions can be used to make, for example, a photoactuatable valve, a fluidic channel, etc. The valve may be associated with a microchannel, including photochromic microchannel. In certain disclosed embodiments, the valve, at least one microchannel, or both, are re-patternable by light exposure. Embodiments of a method for using a photochromic material in a microfluidic device also are disclosed. One disclosed embodiment concerns providing a microfluidic device comprising at least one re-patternable microchannel defined by a spiropyran photochromic material, at least one photoactuatable valve comprising the same or a different spiropyran photochromic material, or both. Spiropyran photochromic material is serially exposed to light of different wavelengths to move a fluid, to actuate a gate or valve, or both. |
| FILED | Wednesday, May 04, 2011 |
| APPL NO | 13/068215 |
| ART UNIT | 1761 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Compositions 252/586 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581584 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mukesh Sharma (Tallahassee, Florida); Myunggi Yi (Busan, South Korea); Hao Dong (Tallahassee, Florida); Huajun Qin (Tallahassee, Florida); David D. Busath (Orem, Utah); Huan-Xiang Zhou (Tallahassee, Florida); Timothy A. Cross (Tallahassee, Florida) |
| ASSIGNEE(S) | Florida State University Research Foundation (Tallahassee, Florida) |
| INVENTOR(S) | Mukesh Sharma (Tallahassee, Florida); Myunggi Yi (Busan, South Korea); Hao Dong (Tallahassee, Florida); Huajun Qin (Tallahassee, Florida); David D. Busath (Orem, Utah); Huan-Xiang Zhou (Tallahassee, Florida); Timothy A. Cross (Tallahassee, Florida) |
| ABSTRACT | The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance. |
| FILED | Thursday, May 26, 2011 |
| APPL NO | 13/067351 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/309 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 08580846 | Lephart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Edwin Douglas Lephart (Orem, Utah); Trent D. Lund (St. Charles, Illinois); Kenneth David Reginald Setchell (Cincinnati, Ohio); Robert J. Handa (Fort Collins, Colorado) |
| ASSIGNEE(S) | Brigham Young University (Provo, Utah); Children's Hospital Medical Center (Cincinnati, Ohio); Colorado State University Research Foundation (Fort Collins, Colorado) |
| INVENTOR(S) | Edwin Douglas Lephart (Orem, Utah); Trent D. Lund (St. Charles, Illinois); Kenneth David Reginald Setchell (Cincinnati, Ohio); Robert J. Handa (Fort Collins, Colorado) |
| ABSTRACT | The invention is directed to a method of preventing or ameliorating a neuropsychiatric or neurodegenerative disease or disorder in a subject. The method includes administering a composition comprising equol in an amount sufficient to prevent or ameliorate the neuropsychiatric or neurodegenerative disease or disorder. The equol may be a racemic mixture of R-equol and S-equol. The equol may be enantiomerically enriched with R-equol or enantiomerically enriched with S-equol. |
| FILED | Friday, August 18, 2006 |
| APPL NO | 11/506443 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/451 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 08578796 | Cho |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Inho Cho (Egg Harbor, New York) |
| ASSIGNEE(S) | U.S. Departement of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Inho Cho (Egg Harbor, New York) |
| ABSTRACT | A device for sampling surfaces for the presence of compounds is provided, including a housing having a proximal end adapted to receive it negative pressure gradient and a distal end adapted to contact the surfaces; a heating element spaced from the distal end; a primary filter spaced from the heating element; and a secondary filter spaced from the primary filter, the secondary filter removably received by the housing. Also provided is as method for sampling a surface for the presence of compounds, the method including contacting the surface to dislodge the compounds from the surface; capturing first fractions of the compounds with a primary filter while allowing second fractions of the compounds to pass through the primary filter; heating the primary filter to volatilize the first fractions; capturing the volatized first fractions and the second fractions with a secondary filter; and analyzing the secondary filter to identify the compounds. |
| FILED | Thursday, June 09, 2011 |
| APPL NO | 13/156778 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/863.110 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 08580769 | Farese |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert V. Farese (St. Petersburg, Florida) |
| ASSIGNEE(S) | The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia); The Roskamp Institute (Sarasota, Florida) |
| INVENTOR(S) | Robert V. Farese (St. Petersburg, Florida) |
| ABSTRACT | Disclosed herein are methods for treating obesity, metabolic syndrome, diabetes, or a combination of these conditions. The methods include selecting a subject with obesity, metabolic syndrome, or diabetes and administering to the subject a therapeutically effective amount of a composition comprising a compound that specifically inhibits hepatic protein kinase C (PKC)-ι, thereby treating the obesity, metabolic syndrome, or diabetes in the subject. In some embodiments the compound that specifically inhibits hepatic PKC-ι includes a thio-gold compound (such as aurothiomalate, aurothioglucose, and auranofin) or a derivative thereof, or a pharmaceutically acceptable salt thereof. In other embodiments, the compound that specifically inhibits hepatic PKC-ι includes 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-[1R-(1α,2β,3β,4α)] (ICAPP) or a derivative thereof, or a pharmaceutically acceptable salt thereof. |
| FILED | Friday, March 09, 2012 |
| APPL NO | 13/417075 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/94 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 08580138 | Olson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John Melvin Olson (Boulder, Colorado) |
| ASSIGNEE(S) | ACTA Technology Inc (Boulder, Colorado) |
| INVENTOR(S) | John Melvin Olson (Boulder, Colorado) |
| ABSTRACT | This invention covers nanofluids. Nanofluids are a combination of particles between 1 and 100 nanometers, a surfactant and the base fluid. The nanoparticles for this invention are either pyrogenic nanoparticles or carbon nanotubes. These nanofluids improve the heat transfer of the base fluids. The base fluid can be ethylene glycol, or propylene glycol, or an aliphatic-hydrocarbon based heat transfer fluid. This invention also includes a method of making nanofluids. No surfactant is used to suspend the pyrogenic nanoparticles in glycols. |
| FILED | Sunday, September 11, 2011 |
| APPL NO | 13/229737 |
| ART UNIT | 1767 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Compositions 252/74 |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 08579186 | McDonald |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Glenn E McDonald (Alexandria, Virginia) |
| ASSIGNEE(S) | United States Postal Service (Washington, District of Columbia) |
| INVENTOR(S) | Glenn E McDonald (Alexandria, Virginia) |
| ABSTRACT | A system and method of tracking a plurality of items during transfer from a source location to a destination. One embodiment is a method comprising associating information identifying the plurality of items with a radio frequency (RF) tag that identifies a carrier unit. The method further comprises storing said associated information in at least one of the RF tag and a computer memory. The method further comprises communicating with the RF tag to identify the location of the carrier unit. The method further comprises identifying the location of at least one of the plurality of items based at least in part on the location of the carrier unit. Another embodiment is a system configured to perform an embodiment of the method. |
| FILED | Tuesday, February 21, 2012 |
| APPL NO | 13/401722 |
| ART UNIT | 2887 — Optics |
| CURRENT CPC | Registers 235/375 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 08580515 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wei Zhao (Little Rock, Arkansas); Chulho Song (An-Yang, South Korea) |
| ASSIGNEE(S) | Board of Trustees of the University of Arkansas (Little Rock, Arkansas) |
| INVENTOR(S) | Wei Zhao (Little Rock, Arkansas); Chulho Song (An-Yang, South Korea) |
| ABSTRACT | A method for surface modification of single walled carbon nanotubes is described. In one embodiment, the method includes the steps of providing a detergent solution, adding a plurality of single walled carbon nanotubes into the detergent solution, performing a first sonication to disperse the single walled carbon nanotubes in the detergent solution, and performing a second sonication after the first sonication to make detergent encased single walled carbon nanotubes. At least one of the plurality of single walled carbon nanotubes is at least partially wrapped by one or more detergent molecules to make it a detergent encased single walled carbon nanotube. In one embodiment, the detergent comprises SDS, PSS or a combination of them. The surface modified carbon nanotubes can be used to detect a chemical compound by associating a solution of the surface modified nanotubes with the chemical compound and optically detecting a chemical property change of the solution. |
| FILED | Friday, November 17, 2006 |
| APPL NO | 11/601328 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.190 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08581191 | Mullins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Richard N. Mullins (Goleta, California); Paul A. Drake (Santa Ynez, California) |
| ASSIGNEE(S) | Raytheon Company (Walthem, Massachusetts) |
| INVENTOR(S) | Richard N. Mullins (Goleta, California); Paul A. Drake (Santa Ynez, California) |
| ABSTRACT | According to one embodiment, an optical device comprises a housing. A structure is disposed within the housing. The structure has an optical entrance whereby radiation may enter. An aperture is located between the optical entrance and a radiation detector. At least one brace is rigidly coupled to the structure and the housing. |
| FILED | Wednesday, December 02, 2009 |
| APPL NO | 12/629676 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Radiant energy 250/338.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, November 12, 2013.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2013/fedinvent-patents-20131112.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page