FedInvent™ Patents
Patent Details for Tuesday, January 28, 2014
This page was updated on Monday, March 27, 2023 at 03:56 AM GMT
Department of Health and Human Services (HHS)
| US 08635911 | Son et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sungmin Son (Cambridge, Massachusetts); Sangwon Byun (Cambridge, Massachusetts); Andrea Kristine Bryan (Allston, Massachusetts); Thomas Burg (Goettingen, Germany); Amneet Gulati (Cambridge, Massachusetts); Jungchul Lee (Seoul, South Korea); Scott Manalis (Cambridge, Massachusetts); Yao-Chung Weng (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Sungmin Son (Cambridge, Massachusetts); Sangwon Byun (Cambridge, Massachusetts); Andrea Kristine Bryan (Allston, Massachusetts); Thomas Burg (Goettingen, Germany); Amneet Gulati (Cambridge, Massachusetts); Jungchul Lee (Seoul, South Korea); Scott Manalis (Cambridge, Massachusetts); Yao-Chung Weng (Cambridge, Massachusetts) |
| ABSTRACT | Method for determining buoyant mass and deformability of a cell. The method includes introducing the cell into a suspended microchannel resonator that includes a constriction near a distal location in the resonator. A first frequency shift in the resonator is monitored as a cell moves to the distal location in the resonator, the first frequency shift being related to the buoyant mass of the cell. Transit time of the cell through the constriction is measured by monitoring a second frequency shift as a result of a change in cell location as it passes through the constriction, whereby deformability is determined from the measured buoyant mass and transit time. |
| FILED | Thursday, April 28, 2011 |
| APPL NO | 13/096248 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/579 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636032 | Burns et al. |
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| APPLICANT(S) | Mark A. Burns (Ann Arbor, Michigan); Sean M. Langelier (Ann Arbor, Michigan); Dustin S. Chang (Mt. Laurel, New Jersey) |
| ASSIGNEE(S) | National Institute of Health (NIH) (Washington, District of Columbia); U.S. Dept. of Health and Human Services (DHHS) (Washington, District of Columbia); U.S. Government of the United States as Represented by the NIH Division of Extramural Inventions and Technology Resources (DEITR) (Washington, District of Columbia) |
| INVENTOR(S) | Mark A. Burns (Ann Arbor, Michigan); Sean M. Langelier (Ann Arbor, Michigan); Dustin S. Chang (Mt. Laurel, New Jersey) |
| ABSTRACT | An acoustical fluid control mechanism and a method of controlling fluid flow of a working fluid with the acoustical fluid control mechanism are provided. The mechanism comprises a resonance chamber that defines a cavity. The resonance chamber has a port. The cavity is sealed from the ambient but for the port for enabling oscillatory flow of a working fluid into and out of the cavity upon exposure of the resonance chamber to an acoustic signal containing a tone at a frequency that is substantially similar to a particular resonance frequency of the resonance chamber. The mechanism further includes a rectifier for introducing directional bias to the oscillatory flow of the working fluid through the port. The rectifier has an inlet connected to the port and an outlet for transmitting the directional flow of the working fluid away from the cavity. The outlet is in fluid communication with the port of the resonance chamber at least during transmission of the directional flow of the working fluid therethrough. |
| FILED | Friday, November 13, 2009 |
| APPL NO | 13/129276 |
| ART UNIT | 3753 — Fluid Handling and Dispensing |
| CURRENT CPC | Fluid handling 137/828 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636713 | Prausnitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mark R. Prausnitz (Atlanta, Georgia); Henry F. Edelhauser (Atlanta, Georgia); Samirkumar Rajnikant Patel (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Mark R. Prausnitz (Atlanta, Georgia); Henry F. Edelhauser (Atlanta, Georgia); Samirkumar Rajnikant Patel (Atlanta, Georgia) |
| ABSTRACT | Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye. |
| FILED | Monday, April 23, 2012 |
| APPL NO | 13/453407 |
| ART UNIT | 3763 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery 64/521 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636978 | Wood et al. |
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| FUNDED BY |
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| APPLICANT(S) | Bradford J. Wood (Potomac, Maryland); Matthew Dreher (Rockville, Maryland); Ayele H. Negussie (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as Represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Bradford J. Wood (Potomac, Maryland); Matthew Dreher (Rockville, Maryland); Ayele H. Negussie (Washington, District of Columbia) |
| ABSTRACT | Cyclized peptide compounds containing the NGR motif of formula (I) or a pharmaceutically-acceptable salt thereof are disclosed. Compositions comprising the cyclized peptide compounds and methods of their use are also disclosed. |
| FILED | Monday, June 15, 2009 |
| APPL NO | 13/000543 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/1.690 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636986 | Van Dyke |
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| APPLICANT(S) | Thomas E. Van Dyke (West Roxbury, Massachusetts) |
| ASSIGNEE(S) | The Forsyth Institute (Cambridge, Massachusetts) |
| INVENTOR(S) | Thomas E. Van Dyke (West Roxbury, Massachusetts) |
| ABSTRACT | The present invention provides new methods for inducing or promoting bone growth and/or for reducing or preventing bone deterioration in a mammal subject. The inventive methods generally comprise administering to the subject an effective amount of a resolvin. In particular, the inventive methods may be useful for treating or preventing conditions associated with bone degradation, deterioration or degeneration such as periodontal disease, osteoarthritis, and metastatic bone disease and osteolytic bone disease. Pharmaceutical compositions and kits comprising at least one resolvin are also provided that can be used to performed the inventive methods. |
| FILED | Friday, November 17, 2006 |
| APPL NO | 12/094016 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/49 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636997 | Martin et al. |
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| APPLICANT(S) | Roland Martin (Bethesda, Maryland); Henry McFarland (Gaithersburg, Maryland); Bibiana Bielekova (Kensington, Maryland); Thomas Waldmann (Silver Spring, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Roland Martin (Bethesda, Maryland); Henry McFarland (Gaithersburg, Maryland); Bibiana Bielekova (Kensington, Maryland); Thomas Waldmann (Silver Spring, Maryland) |
| ABSTRACT | Disclosed is a method of administering an interleukin-2 receptor (IL-2R) antagonist to a subject to treat an autoimmune disease. In particular embodiments, the IL-2R antagonist is an anti-IL-2R monoclonal antibody specific for one or more chains of the IL-2R, such as the alpha-chain, for example daclizumab. In other particular embodiments the autoimmune disease is multiple sclerosis. In certain embodiments administration of interferon-beta is combined with administration of an antagonist of the IL-2R to provide significant clinical improvement in a subject with an autoimmune disease. |
| FILED | Wednesday, September 12, 2012 |
| APPL NO | 13/612763 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/85.600 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636999 | Pogliano et al. |
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| APPLICANT(S) | Joe Pogliano (San Diego, California); Alan Derman (San Diego, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Joe Pogliano (San Diego, California); Alan Derman (San Diego, California) |
| ABSTRACT | The invention provides compositions and methods for stable plasmid maintenance and protein expression in bacteria. Further provided are compositions and methods for promoting competence in bacteria that are otherwise not transformable. |
| FILED | Wednesday, June 16, 2010 |
| APPL NO | 13/378516 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637009 | Landry et al. |
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| APPLICANT(S) | Donald W. Landry (New York, New York); James H. Woods (Ann Arbor, Michigan); Roger K. Sunahara (Ann Arbor, Michigan); Diwahar L. Narasimhan (Ann Arbor, Michigan); Joanne MacDonald (New York, New York); Milan N. Stojanovich (Fort Lee, New Jersey); John J. Tesmer (Ann Arbor, Michigan); Remy L. Brim (Farmington Hills, Michigan) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Donald W. Landry (New York, New York); James H. Woods (Ann Arbor, Michigan); Roger K. Sunahara (Ann Arbor, Michigan); Diwahar L. Narasimhan (Ann Arbor, Michigan); Joanne MacDonald (New York, New York); Milan N. Stojanovich (Fort Lee, New Jersey); John J. Tesmer (Ann Arbor, Michigan); Remy L. Brim (Farmington Hills, Michigan) |
| ABSTRACT | Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition. |
| FILED | Thursday, July 10, 2008 |
| APPL NO | 12/667895 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/94.600 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637013 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yang Liu (Ann Arbor, Michigan); Pan Zheng (Ann Arbor, Michigan); Guo-Yun Chen (Ann Arbor, Michigan); Xincheng Zheng (Ann Arbor, Michigan); Xi Cheng (Woodland, California); Steve Kunkel (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Yang Liu (Ann Arbor, Michigan); Pan Zheng (Ann Arbor, Michigan); Guo-Yun Chen (Ann Arbor, Michigan); Xincheng Zheng (Ann Arbor, Michigan); Xi Cheng (Woodland, California); Steve Kunkel (Ann Arbor, Michigan) |
| ABSTRACT | The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient. |
| FILED | Wednesday, March 21, 2012 |
| APPL NO | 13/426392 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/130.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637020 | Choi et al. |
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| APPLICANT(S) | Yongwon Choi (New York, New York); Brian Wong (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Yongwon Choi (New York, New York); Brian Wong (New York, New York) |
| ABSTRACT | A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal. |
| FILED | Wednesday, August 15, 2012 |
| APPL NO | 13/586514 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/133.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637028 | Alexis et al. |
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| FUNDED BY |
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| APPLICANT(S) | Frank Alexis (Greenville, South Carolina); Matteo Iannacone (Milan, Italy); Jinjun Shi (Boston, Massachusetts); Pamela Basto (Boston, Massachusetts); Elliott Ashley Moseman (Jamaica Plain, Massachusetts); Ulrich von Andrian (Chestnut Hill, Massachusetts); Robert S. Langer (Newton, Massachusetts); Omid C. Farokhzad (Waban, Massachusetts); Elena Tonti (Riccione, Italy) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital (Boston, Massachusetts) |
| INVENTOR(S) | Frank Alexis (Greenville, South Carolina); Matteo Iannacone (Milan, Italy); Jinjun Shi (Boston, Massachusetts); Pamela Basto (Boston, Massachusetts); Elliott Ashley Moseman (Jamaica Plain, Massachusetts); Ulrich von Andrian (Chestnut Hill, Massachusetts); Robert S. Langer (Newton, Massachusetts); Omid C. Farokhzad (Waban, Massachusetts); Elena Tonti (Riccione, Italy) |
| ABSTRACT | The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. |
| FILED | Friday, October 09, 2009 |
| APPL NO | 13/123888 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/143.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637036 | Mascola et al. |
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| APPLICANT(S) | John R. Mascola (Rockville, Maryland); Richard T. Wyatt (San Diego, California); Xueling Wu (Potomac, Maryland); Yuxing Li (Boyds, Maryland); Carl-Magnus Hogerkorp (Vellinge, Sweden); Mario Roederer (Washington, District of Columbia); Zhi-yong Yang (Potomac, Maryland); Gary J. Nabel (Washington, District of Columbia); Peter D. Kwong (Washington, District of Columbia); Tongqing Zhou (Boyds, Maryland); Mark Connors (Bethesda, Maryland); William R. Schief (Encinitas, California) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); University of Washington (Seattle, Washington) |
| INVENTOR(S) | John R. Mascola (Rockville, Maryland); Richard T. Wyatt (San Diego, California); Xueling Wu (Potomac, Maryland); Yuxing Li (Boyds, Maryland); Carl-Magnus Hogerkorp (Vellinge, Sweden); Mario Roederer (Washington, District of Columbia); Zhi-yong Yang (Potomac, Maryland); Gary J. Nabel (Washington, District of Columbia); Peter D. Kwong (Washington, District of Columbia); Tongqing Zhou (Boyds, Maryland); Mark Connors (Bethesda, Maryland); William R. Schief (Encinitas, California) |
| ABSTRACT | Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes. |
| FILED | Friday, March 23, 2012 |
| APPL NO | 13/429286 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/160.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637040 | Whittum-Hudson et al. |
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| APPLICANT(S) | Judith Whittum-Hudson (Novi, Michigan); Alan P. Hudson (Novi, Michigan) |
| ASSIGNEE(S) | National Institute of Health (NIH), U.S. Dept. of Health and Human Services (DHHS) (Washington, District of Columbia) |
| INVENTOR(S) | Judith Whittum-Hudson (Novi, Michigan); Alan P. Hudson (Novi, Michigan) |
| ABSTRACT | Peptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to antigen-binding regions of an anti-idiotypic antibody (mAb2) specific for anti-GLXA antibody (Ab1) which act as molecular mimics of GLXA are also disclosed used as immunogens to induce broadly reactive genus-specific anti-chlamydial antibodies. These peptides and immunogenic DNA encoding the mAb2-like peptides, microparticle or nanoparticle formulations and other formulations of these peptides are disclosed as are methods for immunizing subjects to obtain genus-specific anti-chlamydial antibodies and to treat or prevent Chlamydia-associated or induced rheumatoid arthritis. |
| FILED | Monday, September 21, 2009 |
| APPL NO | 13/120071 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/185.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637044 | Barnett et al. |
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| APPLICANT(S) | Susan Barnett (Emeryville, California); Rino Rappuoli (Siena, Italy); Victoria A Sharma (Emeryville, California); Indresh K Srivastava (Emeryville, California); Jan Zur Megede (Emeryville, California) |
| ASSIGNEE(S) | Novartis AG (Basel, Switzerland) |
| INVENTOR(S) | Susan Barnett (Emeryville, California); Rino Rappuoli (Siena, Italy); Victoria A Sharma (Emeryville, California); Indresh K Srivastava (Emeryville, California); Jan Zur Megede (Emeryville, California) |
| ABSTRACT | Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides. |
| FILED | Thursday, March 22, 2012 |
| APPL NO | 13/427234 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/192.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637050 | Beall et al. |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services, Centers for Disease Control and Prevention (Washington, District of Columbia) |
| INVENTOR(S) | Bernard W. Beall (Doraville, Georgia); George M. Carlone (Stone Mountain, Georgia); Jacquelyn S. Sampson (College Park, Georgia); Edwin W. Ades (Atlanta, Georgia) |
| ABSTRACT | This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of the most prevalent United States (U.S.) Group A Streptococcus (GAS) serotypes. At least some of the synthetic peptides can be recognized by M type-specific antibodies and are capable of eliciting functional opsonic antibodies and/or anti-attachment antibodies without eliciting tissue cross-reactive antibodies. In another aspect, it relates to compositions or vaccines comprising these synthetic serotype-specific peptides, including polypeptides and proteins. The invention may also be isolated antibodies which are raised in response to the peptides, compositions or vaccines. The invention further relates to kits for using the peptides, compositions, or antibodies. In still further aspects, the invention also relates to methods for using the peptides, compositions, vaccines, or antibodies and methods for tailoring vaccines. |
| FILED | Monday, March 18, 2013 |
| APPL NO | 13/846166 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/244.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637065 | Athanasiou et al. |
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| APPLICANT(S) | Kyriacos A. Athanasiou (Houston, Texas); Ying Deng (Sioux Falls, South Dakota); Jerry Hu (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Kyriacos A. Athanasiou (Houston, Texas); Ying Deng (Sioux Falls, South Dakota); Jerry Hu (Houston, Texas) |
| ABSTRACT | Methods for inducing differentiation of dermis-derived cells to serve as a source of chondrocytes and associated methods of use in forming tissue engineered constructs. One example of a method is a method for inducing differentiation of cells into chondrocytes comprising providing aggrecan sensitive isolated dermis cells and seeding the cells onto an aggrecan coated surface. |
| FILED | Monday, October 06, 2008 |
| APPL NO | 12/246320 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/423 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637074 | Castor |
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| APPLICANT(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ASSIGNEE(S) | Aphios Corporation (Woburn, Massachusetts) |
| INVENTOR(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ABSTRACT | This invention is for an improved process to co-encapsulate hydrophobic drugs and hydrophilic drugs in phospholipid liposomes. Non-toxic supercritical or near-critical fluids with/without polar cosolvents are utilized to solubilize phospholipid materials and hydrophobic drugs, and form uniform liposomes to encapsulate hydrophobic drugs and hydrophilic drugs. |
| FILED | Tuesday, March 31, 2009 |
| APPL NO | 12/384007 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/450 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637090 | Ohtake et al. |
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| APPLICANT(S) | Satoshi Ohtake (Milpitas, California); Vu Truong-Le (Campbell, California); David Lechuga-Ballesteros (San Jose, California); Luisa Yee (Los Altos, California); Binh V Pham (Mountain View, California); Russell Martin (Los Gatos, California); Atul Saxena (Milpitas, California) |
| ASSIGNEE(S) | Aridis Pharmaceuticals (San Jose, California) |
| INVENTOR(S) | Satoshi Ohtake (Milpitas, California); Vu Truong-Le (Campbell, California); David Lechuga-Ballesteros (San Jose, California); Luisa Yee (Los Altos, California); Binh V Pham (Mountain View, California); Russell Martin (Los Gatos, California); Atul Saxena (Milpitas, California) |
| ABSTRACT | A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof. |
| FILED | Tuesday, May 04, 2010 |
| APPL NO | 13/318774 |
| ART UNIT | 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/650 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637232 | Lama |
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| FUNDED BY |
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| APPLICANT(S) | Vibha Lama (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Vibha Lama (Ann Arbor, Michigan) |
| ABSTRACT | The present invention pertains to the monitoring and treatment of lung transplant recipients. In particular, the invention pertains to the use of biomarkers to predict or detect post-lung transplantation complications (e.g., organ rejection, acute organ rejection, organ injury, bronchiolitis obliterans, bronchiolitis obliterans syndrome, organizing pneumonia), fibroproliferative repair responses, interstitial lung diseases (e.g., idiopathic pulmonary fibrosis and other fibrotic lung diseases), and other immune-mediated lung diseases (e.g., graft versus host disease, scleroderma). |
| FILED | Friday, January 21, 2011 |
| APPL NO | 13/011541 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/4 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637234 | Shaw et al. |
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| FUNDED BY |
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| APPLICANT(S) | George M. Shaw (Birmingham, Alabama); James E. Robinson (New Orleans, Louisiana); Frederic Bibollet-Ruche (Birmingham, Alabama); Julie M. Decker (Alabaster, Alabama); Beatrice H. Hahn (Birmingham, Alabama); Peter D. Kwong (Bethesda, Maryland) |
| ASSIGNEE(S) | UAB Research Foundation (Birmingham, Alabama); The Administrators of Tulane Educational Fund (New Orleans, Louisiana); The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | George M. Shaw (Birmingham, Alabama); James E. Robinson (New Orleans, Louisiana); Frederic Bibollet-Ruche (Birmingham, Alabama); Julie M. Decker (Alabaster, Alabama); Beatrice H. Hahn (Birmingham, Alabama); Peter D. Kwong (Bethesda, Maryland) |
| ABSTRACT | Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are provided for detecting HIV-1 binding antibodies in a subject infected with HTV-1. Further provided are methods to determine an epitope for an HIV-1 binding antibody; methods to assay for an HIV-1 binding antibody; methods to identify a soluble CD4 mimic; methods to neutralize an non-HIV-1 virus; diagnostic assays to monitor HIV disease in a subject or to monitor the subject's response to immunization by a HIV vaccine; and methods to alter the neutralization potential of an HIV-1 derived CD4-induced antibody. Chimeric polypeptides, chimeric polynucleotides, kits, cells and viruses are also provided. |
| FILED | Friday, April 08, 2005 |
| APPL NO | 11/578761 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/5 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637237 | Henrich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vincent C. Henrich (Greensboro, North Carolina); Cary Alan Weinberger (Carrboro, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Greensboro (Greensboro, North Carolina) |
| INVENTOR(S) | Vincent C. Henrich (Greensboro, North Carolina); Cary Alan Weinberger (Carrboro, North Carolina) |
| ABSTRACT | Ecdysteroid action in Drosophila melanogaster and other insects is mediated by the dimerization of two nuclear receptors, the ecdysone receptor (EcR) and Ultraspiracle (USP), which regulate the transcription of target genes. Disclosed are nucleic acid constructs to identify insecticides having the ability to modify insect development and growth in a developmental stage-specific and/or species-specific manner. |
| FILED | Thursday, October 05, 2006 |
| APPL NO | 11/543682 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637239 | Furuta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Glenn T. Furuta (Aurora, Colorado); Steven J. Ackerman (Naperville, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois); The Regents of the University of Colorado, A Body Corporate (Denver, Colorado) |
| INVENTOR(S) | Glenn T. Furuta (Aurora, Colorado); Steven J. Ackerman (Naperville, Illinois) |
| ABSTRACT | The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation. |
| FILED | Wednesday, November 05, 2008 |
| APPL NO | 12/741549 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637240 | Tian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Qiang Tian (Seattle, Washington); Greg D. Foltz (Seattle, Washington); Leroy Hood (Seattle, Washington); Xiaowei Yan (Bellevue, Washington) |
| ASSIGNEE(S) | Institute for Systems Biology (Seattle, Washington) |
| INVENTOR(S) | Qiang Tian (Seattle, Washington); Greg D. Foltz (Seattle, Washington); Leroy Hood (Seattle, Washington); Xiaowei Yan (Bellevue, Washington) |
| ABSTRACT | Signatures indicative of cancer grades are based on over- and under-expression of 214 genes that characterize expression patterns in CD133+ cells. |
| FILED | Tuesday, September 28, 2010 |
| APPL NO | 12/892710 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637243 | Benkovic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Stephen J Benkovic (State College, Pennsylvania); Frank Salinas (Wheaton, Illinois) |
| ASSIGNEE(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| INVENTOR(S) | Stephen J Benkovic (State College, Pennsylvania); Frank Salinas (Wheaton, Illinois) |
| ABSTRACT | A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein and a clamp loader protein, derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems. |
| FILED | Thursday, December 20, 2012 |
| APPL NO | 13/722497 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637246 | Garraway et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Levi Garraway (Newton, Massachusetts); Caroline Emery (Brookline, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Levi Garraway (Newton, Massachusetts); Caroline Emery (Brookline, Massachusetts) |
| ABSTRACT | The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of BRAF. In particular embodiments, the invention concerns mutations in a BRAF sequence that confer resistance to a BRAF inhibitor. Identification of such mutations in a BRAF sequence allows the identification and design of second-generation BRAF inhibitors. Methods and kits for detecting the presence of a mutant BRAF sequence in a sample are also provided. |
| FILED | Tuesday, February 22, 2011 |
| APPL NO | 13/580651 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.110 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637255 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | James M. Wilson (Glen Mills, Pennsylvania); Weidong Xiao (Fort Washington, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | James M. Wilson (Glen Mills, Pennsylvania); Weidong Xiao (Fort Washington, Pennsylvania) |
| ABSTRACT | The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors. |
| FILED | Wednesday, March 16, 2011 |
| APPL NO | 13/048936 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.190 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637261 | Sklar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Larry A Sklar (Albuquerque, New Mexico); Bruce Edwards (Albuquerque, New Mexico); Frederick Kuckuck (Albuquerque, New Mexico) |
| ASSIGNEE(S) | STC.UNM (, New Mexico) |
| INVENTOR(S) | Larry A Sklar (Albuquerque, New Mexico); Bruce Edwards (Albuquerque, New Mexico); Frederick Kuckuck (Albuquerque, New Mexico) |
| ABSTRACT | The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus. |
| FILED | Tuesday, August 14, 2012 |
| APPL NO | 13/585165 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637267 | Keiler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kenneth C. Keiler (Boalsburg, Pennsylvania); Stephen J. Benkovic (State College, Pennsylvania) |
| ASSIGNEE(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| INVENTOR(S) | Kenneth C. Keiler (Boalsburg, Pennsylvania); Stephen J. Benkovic (State College, Pennsylvania) |
| ABSTRACT | Inhibitors of the tmRNA pathway have antibacterial activity with broad species specificity, including B. anthracis and other pathogens of military and civilian interest. Identified cyclic or linear peptides are further selected by in vivo selection methods, kill bacterial pathogens when added exogenously, and/or eliminate plasmids carrying antibiotic resistance or virulence genes. The molecular target of each cyclic peptide is in the tmRNA pathway and the tmRNA pathway is inhibited in vitro and in vivo by the addition of the peptides. |
| FILED | Monday, April 28, 2008 |
| APPL NO | 12/111096 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/8 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637268 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Junmei Chen (Seattle, Washington); Dominic W. Chung (Bellevue, Washington); Jose Aron Lopez (Seattle, Washington) |
| ASSIGNEE(S) | Puget Sound Blood Center (Seattle, Washington) |
| INVENTOR(S) | Junmei Chen (Seattle, Washington); Dominic W. Chung (Bellevue, Washington); Jose Aron Lopez (Seattle, Washington) |
| ABSTRACT | Novel methods are described for measuring the rate of ADAMTS13-mediated cleavage of von Willebrand Factor (VWF) multimers. Through the use of the reagent, ristocetin, the method can advantageously be performed in the absence of an applied shear stress or added denaturing agent. Also described are methods for diagnosing ADAMTS13-associated disorders and methods for providing improved treatment of those disorders by evaluating the efficacy of the treatment using the methods as described. |
| FILED | Friday, November 04, 2011 |
| APPL NO | 13/289474 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/13 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637287 | Thorson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jon S. Thorson (Middleton, Wisconsin); Richard W. Gantt (Roswell, Georgia) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Jon S. Thorson (Middleton, Wisconsin); Richard W. Gantt (Roswell, Georgia) |
| ABSTRACT | The present invention generally relates to materials and methods for exploiting glycosyltransferase reversibility for nucleotide diphosphate (NDP) sugar synthesis. The present invention provides engineered glycosyltransferase enzymes characterized by improved reaction reversibility and expanded sugar donor specificity as compared to corresponding non-mutated glycosyltransferase enzymes. Such reagents provide advantageous routes to NDP sugars for subsequent use in a variety of biomedical applications, including enzymatic and chemoenzymatic glycorandomization. |
| FILED | Monday, June 13, 2011 |
| APPL NO | 13/159097 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/193 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637301 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeff Tza-Huei Wang (Baltimore, Maryland); Kelvin J. Liu (Baltimore, Maryland); Christopher M. Puleo (Glenville, New York); Tushar D. Rane (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jeff Tza-Huei Wang (Baltimore, Maryland); Kelvin J. Liu (Baltimore, Maryland); Christopher M. Puleo (Glenville, New York); Tushar D. Rane (Baltimore, Maryland) |
| ABSTRACT | A microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with the concentration section, and a detection region that is at least partially transparent to illumination light of the confocal fluorescence detection system and at least partially transparent to fluorescent light when emitted from a sample under observation as the sample flows through the detection region. |
| FILED | Tuesday, March 02, 2010 |
| APPL NO | 13/147742 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/283.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637306 | Young et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Travis Young (San Diego, California); Peter G. Schultz (La Jolla, California) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Travis Young (San Diego, California); Peter G. Schultz (La Jolla, California) |
| ABSTRACT | Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods are also provided. In addition, orthogonal translation systems in methylotrophic yeast and methods of using these systems to produce carrier and target polypeptide variants comprising unnatural amino acids are provided. |
| FILED | Wednesday, December 09, 2009 |
| APPL NO | 12/653274 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/325 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637310 | McBride et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alison McBride (Bethesda, Maryland); Sandra Chapman (Washington, District of Columbia); Jonathan Vogel (Bethesda, Maryland); Atsushi Terunuma (Rockville, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Alison McBride (Bethesda, Maryland); Sandra Chapman (Washington, District of Columbia); Jonathan Vogel (Bethesda, Maryland); Atsushi Terunuma (Rockville, Maryland) |
| ABSTRACT | Disclosed herein is the finding that treatment with a ROCK inhibitor increases proliferation and induces immortalization of primary keratinocytes. Accordingly, provided is a method of immortalizing primary keratinocytes by exposure to a ROCK inhibitor. Also provided are immortalized primary keratinocytes produced by the described method, as well as organotypic tissue equivalents and cell cultures comprising the immortalized primary keratinocytes. Furthermore, ROCK inhibitor-treated cells show a greatly increased ability to support viral DNA replication of both “low risk” and “high risk” HPV genomes, indicating that ROCK inhibitors will be useful for studying the life cycles of a wide range of HPVs. |
| FILED | Friday, December 04, 2009 |
| APPL NO | 13/132391 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/377 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637313 | Chamberlain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeffrey S. Chamberlain (Seattle, Washington); Dennis J. Hartigan-O'Connor (S Lake Tahoe, California) |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Jeffrey S. Chamberlain (Seattle, Washington); Dennis J. Hartigan-O'Connor (S Lake Tahoe, California) |
| ABSTRACT | The present invention relates to methods and compositions for the production of viral vectors. In particular, the present invention provides methods and compositions for faster, higher titer and higher purity production of viral vectors (e.g. adenoviral vectors). In some embodiments, the present invention provides gutted and helper viruses with identical or similar termini. In other embodiments, the present invention provides terminal protein linked adenoviral DNA. In certain embodiments, the present invention provides template extended adenoviral DNA. |
| FILED | Thursday, September 16, 2010 |
| APPL NO | 12/884027 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/457 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637317 | Pamula et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vamsee K. Pamula (Durham, North Carolina); Arjun Sudarsan (Durham, North Carolina); Ramakrishna Sista (Morrisville, North Carolina) |
| ASSIGNEE(S) | Advanced Liquid Logic, Inc. (Morrisville, North Carolina) |
| INVENTOR(S) | Vamsee K. Pamula (Durham, North Carolina); Arjun Sudarsan (Durham, North Carolina); Ramakrishna Sista (Morrisville, North Carolina) |
| ABSTRACT | The invention provides a method of redistributing magnetically responsive beads in a droplet. The method may include providing a droplet including magnetically responsive beads. The droplet may be provided within a region of a magnetic field having sufficient strength to attract the magnetically responsive beads to an edge of the droplet or towards an edge of the droplet, or otherwise regionalize or aggregate beads within the droplet. The method may also include conducting on a droplet operations surface one or more droplet operations using the droplet without removing the magnetically responsive beads from the region of the magnetic field. The droplet operations may in some cases be electrode-mediated. The droplet operations may redistribute and/or circulate the magnetically responsive beads within the droplet. In some cases, the droplet may include a sample droplet may include a target analyte. The redistributing of the magnetically responsive beads may cause target analyte to bind to the magnetically responsive beads. In some cases, the droplet may include unbound substances in a wash buffer. The redistributing of the magnetically responsive beads causes unbound substances to be freed from interstices of an aggregated set or subset of the magnetically responsive beads. |
| FILED | Thursday, January 06, 2011 |
| APPL NO | 12/985409 |
| ART UNIT | 1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/43 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637324 | Pollack et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael G. Pollack (Durham, North Carolina); Vamsee K. Pamula (Durham, North Carolina); Ramakrishna Sista (Morrisville, North Carolina); Arjun Sudarsan (Cary, North Carolina) |
| ASSIGNEE(S) | Advanced Liquid Logic, Inc. (Morrisville, North Carolina) |
| INVENTOR(S) | Michael G. Pollack (Durham, North Carolina); Vamsee K. Pamula (Durham, North Carolina); Ramakrishna Sista (Morrisville, North Carolina); Arjun Sudarsan (Cary, North Carolina) |
| ABSTRACT | The present invention relates to bead incubating and washing on a droplet actuator. Methods for incubating magnetically responsive beads that are labeled with primary antibody, a sample (i.e., analyte), and secondary reporter antibodies on a magnet, on and off a magnet, and completely off a magnet are provided. Also provided are methods for washing magnetically responsive beads using shape-assisted merging of droplets. Also provided are methods for shape-mediated splitting, transporting, and dispensing of a sample droplet that contains magnetically responsive beads. The apparatuses and methods of the invention provide for rapid time to result and optimum detection of an analyte in an immunoassay. |
| FILED | Thursday, April 07, 2011 |
| APPL NO | 13/081927 |
| ART UNIT | 1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/180 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637325 | Basile et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Franco Basile (Fort Collins, Colorado); Shaofeng Zhang (Exton, Pennsylvania) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming) |
| INVENTOR(S) | Franco Basile (Fort Collins, Colorado); Shaofeng Zhang (Exton, Pennsylvania) |
| ABSTRACT | A method and apparatus for conducting the rapid pyrolysis of peptides, proteins, polymers, and biological materials. The method can be carried out at atmospheric pressures and takes only about 5 to 30 seconds. The samples are cleaved at the C-terminus of aspartic acid. The apparatus employs a probe on which the sample is heated and digested components analyzed. |
| FILED | Monday, February 16, 2009 |
| APPL NO | 12/371893 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/501 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637448 | Fay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Philip J. Fay (Pittsford, New York); Hironao Wakabayashi (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Philip J. Fay (Pittsford, New York); Hironao Wakabayashi (Rochester, New York) |
| ABSTRACT | The invention relates to a recombinant factor VIII that includes one or more mutations at an interface of A1 and C2 domains of recombinant factor VIII. The one or more mutations include substitution of one or more amino acid residues with either a cysteine or an amino acid residue having a higher hydrophobicity. This results in enhanced stability of factor VIII. Methods for making the recombinant factor VIII, pharmaceutical compositions containing the recombinant factor VIII, and use of the recombinant factor VIII for treating hemophilia A are also disclosed. |
| FILED | Tuesday, September 13, 2011 |
| APPL NO | 13/231948 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/1.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637455 | Darby et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Martyn K. Darby (Chapel Hill, North Carolina); Isaac G. Sanford (Durham, North Carolina); R. Edward Benson (Durham, North Carolina); Hanne Gron (Durham, North Carolina); Paul T. Hamilton (Cary, North Carolina); Shrikumar A. Nair (Cary, North Carolina); Doug Buechter (Chester Springs, Pennsylvania); Elliott Gruskin (Malvern, Pennsylvania) |
| ASSIGNEE(S) | Affinergy, LLC (RTP, North Carolina); DePuy Synthes Products, LLC (Raynham, Massachusetts) |
| INVENTOR(S) | Martyn K. Darby (Chapel Hill, North Carolina); Isaac G. Sanford (Durham, North Carolina); R. Edward Benson (Durham, North Carolina); Hanne Gron (Durham, North Carolina); Paul T. Hamilton (Cary, North Carolina); Shrikumar A. Nair (Cary, North Carolina); Doug Buechter (Chester Springs, Pennsylvania); Elliott Gruskin (Malvern, Pennsylvania) |
| ABSTRACT | The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions. |
| FILED | Friday, October 17, 2008 |
| APPL NO | 12/739353 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/3.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637456 | Sasisekharan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ram Sasisekharan (Cambridge, Massachusetts); Karthik Viswanathan (Waltham, Massachusetts); Venkataramanan Soundararajan (Cambridge, Massachusetts); S. Raguram (Hillsborough, New Jersey); Viswanathan Sasisekharan (Cambridge, Massachusetts); Vidya Subramanian (Somerville, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ram Sasisekharan (Cambridge, Massachusetts); Karthik Viswanathan (Waltham, Massachusetts); Venkataramanan Soundararajan (Cambridge, Massachusetts); S. Raguram (Hillsborough, New Jersey); Viswanathan Sasisekharan (Cambridge, Massachusetts); Vidya Subramanian (Somerville, Massachusetts) |
| ABSTRACT | The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them. |
| FILED | Thursday, January 27, 2011 |
| APPL NO | 13/015455 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/3.700 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637459 | Srinivasan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Shanthi Srinivasan (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Shanthi Srinivasan (Atlanta, Georgia) |
| ABSTRACT | Provided herein are pharmaceutical and transplant compositions and methods related to the treatment and prevention of diabetes. More specifically, the compositions and methods are related to activation of glial derived neurotrophic factor (GDNF) receptors or overexpression of the GFR-α1/c-Ret receptor complex in insulin secreting cells so as to promote cell survival and proliferation. |
| FILED | Wednesday, November 07, 2007 |
| APPL NO | 11/936413 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/6.700 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637462 | Simari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert D. Simari (Rochester, Minnesota); Sinny Delacroix (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Robert D. Simari (Rochester, Minnesota); Sinny Delacroix (Rochester, Minnesota) |
| ABSTRACT | This document relates to methods and materials for treating diseases or disorders associated with elevated platelet counts (e.g., essential thrombocythemia, secondary thrombocytosis, congenital amegakaryocytic thrombocytopenia, sepsis, or asplenism) as well as methods and materials for treating diseases or disorders associated with elevated platelet adhesion to collagen (e.g., acute coronary syndromes, angina pectoris, chronic atherosclerosis, diabetes, or hypertension). |
| FILED | Friday, January 27, 2012 |
| APPL NO | 13/360039 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/13.800 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637468 | Peterson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Blake R. Peterson (Lawrence, Kansas) |
| ASSIGNEE(S) | The University of Kansas (Lawrence, Kansas) |
| INVENTOR(S) | Blake R. Peterson (Lawrence, Kansas) |
| ABSTRACT | Synthetic cholesterylamine-linkers can include derivatives of cholesterol, cholesteryl, or sitosteryl coupled through the linker to an agent for delivery into cells. The cholesterylamines are thought to mimic cholesterol in the capacity and mechanism for enhanced entry into cells. The configuration of the cholesterylamine-linker that is thought to provide for enhanced entry into cells includes a cholesterylamine that is coupled to a linker from the amine, and which linker includes a negative charge at a spatial distance from the amine of the cholesterylamine. |
| FILED | Thursday, August 12, 2010 |
| APPL NO | 13/390327 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/20.900 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637472 | Michael et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Scott F. Michael (Estero, Florida); Sharon Isern (Estero, Florida); Joshua Costin (Naples, Florida); Vaikuntanath Samudrala (Seattle, Washington); Ekachai Jenwitheesuk (Ratchaburi, Thailand) |
| ASSIGNEE(S) | University of Washington Through Its Center for Commercialization (Seattle, Washington); Florida Gulf Coast University (Ft. Myers, Florida) |
| INVENTOR(S) | Scott F. Michael (Estero, Florida); Sharon Isern (Estero, Florida); Joshua Costin (Naples, Florida); Vaikuntanath Samudrala (Seattle, Washington); Ekachai Jenwitheesuk (Ratchaburi, Thailand) |
| ABSTRACT | The invention relates peptide entry inhibitors and methods of determining such inhibitors that are bindable to regions of viruses having class II E proteins, such as the dengue virus E protein, as candidates for in vivo anti-viral compounds. |
| FILED | Friday, July 11, 2008 |
| APPL NO | 12/668808 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/21.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637485 | Secrist, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John A. Secrist, III (Birmingham, Alabama); Steven Ealick (Ithaca, New York); Shridhar Bale (Ithaca, New York); Anthony E. Pegg (Hershey, Pennsylvania); Diane E. McCloskey (Hershey, Pennsylvania); Wayne C. Guida (St. Pete Beach, Florida) |
| ASSIGNEE(S) | Southern Research Institute (Birmingham, Alabama); Cornell University (Ithica, New York); H. Lee Moffitt Cancer and Research Institute (Tampa, Florida); The Penn State Research Foundation (University Park, Pennsylvania) |
| INVENTOR(S) | John A. Secrist, III (Birmingham, Alabama); Steven Ealick (Ithaca, New York); Shridhar Bale (Ithaca, New York); Anthony E. Pegg (Hershey, Pennsylvania); Diane E. McCloskey (Hershey, Pennsylvania); Wayne C. Guida (St. Pete Beach, Florida) |
| ABSTRACT | The crystal structure of the complex of S-adenosylmethionine methyl ester with hΛdoMetDC F223A, a mutant where the stacking of the aromatic rings of F7, adenine and F223 would be eliminated. The structure of this mutant with the ester shows that the ligand still maintains a syn conformation aided by pi-pi interactions to F7, hydrogen bonds to the backbone of Glu67, and electrostatic interactions. Several series of AdoMet substrate analogues with a variety of substituents at the 8 position of adenine were synthesized and analyzed for their ability to inhibit hAdoMetDC. To understand these results, virtual modeling of the enzyme inhibitor complexes and the crystal structures of human AdoMetDC with 5′-deoxy-5′-[N-methyl-N-[2-(aminooxy)ethyl]amino-8-methyl]adenosine (MAOEMA) and 5′-deoxy-5′-[N-methyl-N-[4-(aminooxy)butyl]amino-8-ethyl]adenosine (MAOBEA) at the active site have been determined experimentally. |
| FILED | Friday, August 01, 2008 |
| APPL NO | 12/671121 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/46 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637490 | Peng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xiaohua Peng (Milwaukee, Wisconsin); Yunyan Kuang (Shanghai, China PRC); Sheng Cao (Milwaukee, Wisconsin); Wenbing Chen (Milwaukee, Wisconsin); Yibin Wang (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin) |
| INVENTOR(S) | Xiaohua Peng (Milwaukee, Wisconsin); Yunyan Kuang (Shanghai, China PRC); Sheng Cao (Milwaukee, Wisconsin); Wenbing Chen (Milwaukee, Wisconsin); Yibin Wang (Milwaukee, Wisconsin) |
| ABSTRACT | Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of treating cancer using the compounds. |
| FILED | Sunday, July 01, 2012 |
| APPL NO | 13/539471 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/64 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637493 | Ross et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alonzo H. Ross (Shrewsbury, Massachusetts); Candace Gilbert (Worcester, Massachusetts); Richard Moser (Worcester, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Shrewsbury, Massachusetts) |
| INVENTOR(S) | Alonzo H. Ross (Shrewsbury, Massachusetts); Candace Gilbert (Worcester, Massachusetts); Richard Moser (Worcester, Massachusetts) |
| ABSTRACT | Described are methods for treating cancers, e.g., glioblastoma, including administering an inhibitor of Notch signalling, e.g., a gamma secretase inhibitor, in combination with a chemotherapeutic agent. |
| FILED | Wednesday, November 10, 2010 |
| APPL NO | 12/943666 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/155 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637560 | Trenkle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Trenkle (Bethesda, Maryland); Adrian Wiestner (Bethesda, Maryland); Qiuyan Wang (Bethesda, Maryland); Yihong Ye (Germantown, Maryland); Helena Mora-Jensen (Copenhagen, Denmark) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | William Trenkle (Bethesda, Maryland); Adrian Wiestner (Bethesda, Maryland); Qiuyan Wang (Bethesda, Maryland); Yihong Ye (Germantown, Maryland); Helena Mora-Jensen (Copenhagen, Denmark) |
| ABSTRACT | The present invention features imidazolidinone compounds and pharmaceutical compositions of imidazolidinone compounds. The compounds of the invention are utilized in methods of treating a deubiquitination-related disorder in a subject and inhibiting p97-associated deubiquitination. |
| FILED | Friday, July 18, 2008 |
| APPL NO | 12/669361 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/386 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637565 | Fenical et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Fenical (Del Mar, California); Paul Jensen (San Diego, California); Tracy Mincer (San Diego, California); Robert H.R. Feling (Wiesbaden, Germany) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | William Fenical (Del Mar, California); Paul Jensen (San Diego, California); Tracy Mincer (San Diego, California); Robert H.R. Feling (Wiesbaden, Germany) |
| ABSTRACT | The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi. |
| FILED | Tuesday, May 22, 2012 |
| APPL NO | 13/477364 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/421 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637635 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lianglin Zhang (La Jolla, California); Jason A. Hoffman (La Jolla, California); Erkki Ruoslahti (Buellton, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lianglin Zhang (La Jolla, California); Jason A. Hoffman (La Jolla, California); Erkki Ruoslahti (Buellton, California) |
| ABSTRACT | The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treating any of a varirty of cardiovascular diseases as described below. Thus, the present invention provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CRPPR (SEQ ID NO: 1) or a peptidomimetic thereof. The invention further provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CARPAR (SEQ ID NO: 5) or a peptidomimetic thereof, or amino acid sequence CPKRPR (SEQ ID NO: 6) or a peptidomimtic thereof. |
| FILED | Thursday, January 29, 2009 |
| APPL NO | 12/322371 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637639 | Kobilka et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brian Kobilka (Palo Alto, California); Daniel Rosenbaum (Burlingame, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Brian Kobilka (Palo Alto, California); Daniel Rosenbaum (Burlingame, California) |
| ABSTRACT | Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR. |
| FILED | Friday, March 30, 2012 |
| APPL NO | 13/436709 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/350 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637652 | Philibert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Robert Philibert (Iowa City, Iowa); Anup Madan (Bellevue, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Philibert (Iowa City, Iowa); Anup Madan (Bellevue, Washington) |
| ABSTRACT | The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder by determining a nucleic acid methylation profile from a biological sample from the subject, wherein a given profile indicates that the subject has a predisposition to a substance use disorder. |
| FILED | Friday, October 28, 2011 |
| APPL NO | 13/284425 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/23.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637684 | Shen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ben Shen (Verona, Wisconsin); Zhong-Yin Zhang (Indianapolis, Indiana) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| INVENTOR(S) | Ben Shen (Verona, Wisconsin); Zhong-Yin Zhang (Indianapolis, Indiana) |
| ABSTRACT | The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function. |
| FILED | Thursday, May 05, 2011 |
| APPL NO | 13/101612 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Organic compounds 549/323 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637696 | Gellman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Samuel Helmer Gellman (Madison, Wisconsin); Yonggui Chi (Berkeley, California); Li Guo (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Samuel Helmer Gellman (Madison, Wisconsin); Yonggui Chi (Berkeley, California); Li Guo (Madison, Wisconsin) |
| ABSTRACT | The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide α-substituted-γ-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96-99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected γ2-amino acids, which are essential for systematic conformational studies of γ-peptide foldamers. |
| FILED | Monday, September 17, 2012 |
| APPL NO | 13/621553 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 227/02 (20130101) C07C 269/00 (20130101) C07C 271/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637817 | Krutchinsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew N. Krutchinsky (New York, New York); Vadim Sherman (Brooklyn, New York); Herbert Cohen (New York, New York); Brian T. Chait (New York, New York) |
| ABSTRACT | An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis. |
| FILED | Friday, March 01, 2013 |
| APPL NO | 13/782708 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Radiant energy 250/293 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637944 | Solin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Stuart A. Solin (St. Louis, Missouri); Kirk D. Wallace (St. Louis, Missouri); Samuel A. Wickline (St. Louis, Missouri); Michael S. Hughes (Wildwood, Missouri) |
| ABSTRACT | Disclosed herein is an apparatus comprising a metal shunt and a planar semiconductor material in electrical contact with the metal shunt, the metal shunt located on a surface of the semiconductor material, thereby defining a semiconductor/metal interface for passing a flow of current between the semiconductor material and the metal shunt in response to an application of an electrical bias to the apparatus, wherein a portion of that semiconductor material surface is not covered by the metal shunt, wherein the semiconductor material and the metal shunt lie in different planes that are substantially parallel planes, the semiconductor/metal interface thereby being parallel to the plane of semiconductor material, and wherein, when under the electrical bias, the semiconductor/metal interface is configured to exhibit a change in resistance thereof in response to a perturbation. Such an apparatus can be used as a sensor and deployed as an array of sensors. |
| FILED | Monday, May 06, 2013 |
| APPL NO | 13/888065 |
| ART UNIT | 2823 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/414 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638096 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tao Zhang (Stanford, California); Michael Lustig (Berkeley, California); John M. Pauly (Stanford, California); Shreyas S. Vasanawala (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Tao Zhang (Stanford, California); Michael Lustig (Berkeley, California); John M. Pauly (Stanford, California); Shreyas S. Vasanawala (Stanford, California) |
| ABSTRACT | A computer implemented method for magnetic resonance imaging is provided. A 3D Fourier Transform acquisition is performed with two phase encode directions, wherein phase code locations are chosen so that a total number of phase encodes is less than a Nyquist rate, and closest distances between phase encode locations takes on a multiplicity of values. Readout signals are received through a multi-channel array of a plurality of receivers. An autocalibrating parallel imaging interpolation is performed and a noise correlation is generated. The noise correlation is used to weight a data consistency term of a compressed sensing iterative reconstruction. An image is created from the autocalibration parallel imaging using the weighted data consistency term. The image is displayed. |
| FILED | Tuesday, October 19, 2010 |
| APPL NO | 12/907764 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/309 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638358 | Dabiri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana Dabiri (Brier, Washington); Wei-Hsin Tien (Seattle, Washington); Patrick Kartes (Charlotte, North Carolina); Toru Yamasaki (Osaka, Japan) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Dana Dabiri (Brier, Washington); Wei-Hsin Tien (Seattle, Washington); Patrick Kartes (Charlotte, North Carolina); Toru Yamasaki (Osaka, Japan) |
| ABSTRACT | Three-Dimensional Defocusing Particle Image Velocimetry (3DDPIV) allows for measurement of three-dimensional velocities within a volume. In the disclosed embodiment, a mask with a plurality of apertures is disposed with a lens between the test section and a color camera. The field-of-view is backlit and the test section is seeded with black particles. This configuration allows for a lower power light source as compared to conventional 3DDPIV. Color-coded particle images are formed on a white background, wherein each of the color images is generated from light that travels through the filters not blocked by the imaged particle, thereby producing a color image that is of a color different from the color of any of the filters. A color space linear transformation is used to allow for accurate identification of each pinhole exposure when the color filters' spectrum does not match those of the 3-CCD color camera. |
| FILED | Thursday, March 18, 2010 |
| APPL NO | 12/727167 |
| ART UNIT | 2482 — Recording and Compression |
| CURRENT CPC | Television 348/47 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639311 | Giszter |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Simon F. Giszter (Havertown, Pennsylvania) |
| ASSIGNEE(S) | Philadelphia Health and Education Corporation (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Simon F. Giszter (Havertown, Pennsylvania) |
| ABSTRACT | A single sensing probe comprising multiple, spatially separate, sensing sites is utilized to sense neural activity. The sensing probe includes multiple conductors each with multiple sensing sites in a fixed geometric arrangement. The sensing probe is configured to comprise multiple combined sensing sites in polytrode configuration. By appropriately combining the wire groupings at each combined sensing site, activity sensed from a single wire with multiple sensing sites, can be coupled with other wires to unmix signals from the spatially separate sites and leverage the power of combinatorics to maximize total recording bandwidth and single neuron/unit yield per wire and per probe. |
| FILED | Tuesday, December 14, 2010 |
| APPL NO | 12/967878 |
| ART UNIT | 3739 — Optics |
| CURRENT CPC | Surgery 6/377 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639329 | Brown et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Edgar A. Brown (Decatur, Georgia); James D. Ross (Decatur, Georgia); Richard A. Blum (Atlanta, Georgia); Stephen P. DeWeerth (Decatur, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Edgar A. Brown (Decatur, Georgia); James D. Ross (Decatur, Georgia); Richard A. Blum (Atlanta, Georgia); Stephen P. DeWeerth (Decatur, Georgia) |
| ABSTRACT | Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants. |
| FILED | Tuesday, August 29, 2006 |
| APPL NO | 11/511794 |
| ART UNIT | 3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Surgery: Light, thermal, and electrical application 67/11 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639344 | Greenberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert Jay Greenberg (Los Angeles, California); Neil Hamilton Talbot (Montrose, California); Jordan Matthew Neysmith (Pasadena, California); James Singleton Little (Saugus, California); Brian V. Mech (Stevenson Ranch, California); Mark Humayun (Glendale, California); Dilek Guven (Ankara, Turkey); Anne-Marie de Merlier Ripley (Los Angeles, California) |
| ASSIGNEE(S) | Second Sight Medical Products, Inc. (Sylmar, California) |
| INVENTOR(S) | Robert Jay Greenberg (Los Angeles, California); Neil Hamilton Talbot (Montrose, California); Jordan Matthew Neysmith (Pasadena, California); James Singleton Little (Saugus, California); Brian V. Mech (Stevenson Ranch, California); Mark Humayun (Glendale, California); Dilek Guven (Ankara, Turkey); Anne-Marie de Merlier Ripley (Los Angeles, California) |
| ABSTRACT | Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue. |
| FILED | Friday, April 28, 2006 |
| APPL NO | 11/413689 |
| ART UNIT | 3762 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery: Light, thermal, and electrical application 67/53 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639447 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sangtae Kim (San Diego, California); Nitin Gupta (La Jolla, California); Pavel A. Pevzner (La Jolla, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Sangtae Kim (San Diego, California); Nitin Gupta (La Jolla, California); Pavel A. Pevzner (La Jolla, California) |
| ABSTRACT | A method for identifying peptides using tandem mass spectrometry takes the spectrum for a peptide to be analyzed and uses a scoring function to score a match between the spectrum and each candidate peptide in a peptide database. The scoring function has a value corresponding to a number of fragment peaks in the spectrum that match fragment peaks in a spectrum of the candidate peptide. Using the match scores, a generating function of the spectrum is computed to determine the number of peptide reconstructions at each value of the scoring function. The generating function is then used to determine the number of candidate peptides for each match score and the probability of a peptide having a given match score to the spectrum. A spectral probability can be determined by calculating the total probability of all peptides with scores equal to or larger than the given match score. |
| FILED | Monday, June 02, 2008 |
| APPL NO | 12/602481 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Electric Digital Data Processing G06F 19/12 (20130101) G06F 19/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639450 | Rimm et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David L. Rimm (Branford, Connecticut); Robert L. Camp (Stamford, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | David L. Rimm (Branford, Connecticut); Robert L. Camp (Stamford, Connecticut) |
| ABSTRACT | Systems and methods for rapidly analyzing cell containing samples, for example to identify morphology or to localize and quantitate biomarkers are disclosed. |
| FILED | Wednesday, May 02, 2012 |
| APPL NO | 13/462595 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/19 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 08635916 | Loverich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jacob Loverich (State Colleg, Pennsylvania); Stephen J. Wenner (Port Matilda, Pennsylvania); Jeremy E. Frank (Pine Grove Mills, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Loverich (State Colleg, Pennsylvania); Stephen J. Wenner (Port Matilda, Pennsylvania); Jeremy E. Frank (Pine Grove Mills, Pennsylvania) |
| ABSTRACT | An internal structural monitoring system for a structure that includes a sensor mounted within the structure to measure at least one of strain experienced by the structure and vibration experience by the structure. It includes a first system support mounted and second system support mounted in the structure, where the first system and the second system support are mounted in the structure such that the sensor is between the first system support and the second system support to hold the sensor in position so that the sensor senses at least one of strain and vibration. It includes a wireless communication unit mounted within the structure, the wireless communication unit connected to the sensor to receive data from the sensor and transmit the data to a receiver outside the structure. It includes a power supply mounted within the structure to supply necessary electrical power to the sensor and the communication unit. |
| FILED | Wednesday, July 06, 2011 |
| APPL NO | 13/176959 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/768 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08635940 | Goldfarb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael Goldfarb (Nashville, Tennessee); Xiangrong Shen (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Michael Goldfarb (Nashville, Tennessee); Xiangrong Shen (Tuscaloosa, Alabama) |
| ABSTRACT | A solenoid valve including a spool received within a housing. The spool is configured to move to multiple positions within the housing. The housing includes supply ports, exhaust ports, and outlet ports. When the spool is in a specific location, two outlet ports are in fluid communication with each other. |
| FILED | Monday, January 07, 2008 |
| APPL NO | 12/811802 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Motors: Expansible chamber type 091/464 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08635956 | Rastegar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jahangir S. Rastegar (Stony Brook, New York); Carlos M. Pereira (Tannersville, Pennsylvania); Richard Dratler (Montville, New Jersey) |
| ASSIGNEE(S) | Omnitek Partners LLC (Ronkonkoma, New York) |
| INVENTOR(S) | Jahangir S. Rastegar (Stony Brook, New York); Carlos M. Pereira (Tannersville, Pennsylvania); Richard Dratler (Montville, New Jersey) |
| ABSTRACT | A munition including: a power supply having a piezoelectric material for generating power from a vibration upon impact of the munition; a processor operatively connected to the power supply for initiating detonation time-out circuitry to disable detonation of the munition after a predetermined time. |
| FILED | Saturday, March 09, 2013 |
| APPL NO | 13/792008 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ammunition and explosives 12/210 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08635967 | Chang, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Peter A. Chang, III (Silver Spring, Maryland); Wesley M. Wilson (Ijamsville, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretarey of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Peter A. Chang, III (Silver Spring, Maryland); Wesley M. Wilson (Ijamsville, Maryland) |
| ABSTRACT | A method and apparatus for reducing mixing between a first water-type and a second water-type and for increasing the efficiency of ballast water exchange procedures on a ship. The apparatus includes a plurality of ballast water tanks, each having an arrangement to reduce water-mixing. Each arrangement includes a horizontal flow restraining box and two anti-mixing brackets. The ballast water tanks are divided into a plurality of compartments including a main compartment. The arrangement to reduce the water-mixing is provided in the main compartment of each tank. |
| FILED | Thursday, July 28, 2011 |
| APPL NO | 13/193430 |
| ART UNIT | 3617 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ships 114/125 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636194 | Schultz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeffrey Patrick Schultz (Blacksburg, Virginia); Kevin Creehan (Blacksburg, Virginia) |
| ASSIGNEE(S) | Schultz-Creehan Holdings, Inc. (Blacksburg, Virginia) |
| INVENTOR(S) | Jeffrey Patrick Schultz (Blacksburg, Virginia); Kevin Creehan (Blacksburg, Virginia) |
| ABSTRACT | A low-temperature friction-based coating method termed friction stir fabrication (FSF) is disclosed, in which material is deposited onto a substrate and subsequently stirred into the substrate using friction stir processing to homogenize and refine the microstructure. This solid-state process is capable of depositing coatings, including nanocrystalline aluminum and/or metal matrix composites and the like, onto substrates such as aluminum at relatively low temperatures. A method of making rod stock for use in the FSF process is also disclosed. |
| FILED | Wednesday, June 02, 2010 |
| APPL NO | 12/792655 |
| ART UNIT | 1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Metal fusion bonding 228/112.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636250 | Toni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Darryl M. Toni (Madison, Connecticut); Mary McCarthy (Milford, Connecticut); Bruce H. Barr (Huntington, Connecticut); Anthony Z. Stobiecki (Shelton, Connecticut); Thomas Swift (Monroe, Connecticut); Thomas Dziekonski (Milford, Connecticut) |
| ASSIGNEE(S) | Sikorsky Aircraft Corporation (Stratford, Connecticut) |
| INVENTOR(S) | Darryl M. Toni (Madison, Connecticut); Mary McCarthy (Milford, Connecticut); Bruce H. Barr (Huntington, Connecticut); Anthony Z. Stobiecki (Shelton, Connecticut); Thomas Swift (Monroe, Connecticut); Thomas Dziekonski (Milford, Connecticut) |
| ABSTRACT | An external hook system for a rotary-wing aircraft includes a lower frame interface which accommodates longitudinal and lateral loads and an upper frame interface. A tension member is mountable between the lower frame interface and the upper frame interface to transfer tension loads between the lower frame interface and the upper frame interface. |
| FILED | Monday, March 08, 2010 |
| APPL NO | 13/258545 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeronautics and astronautics 244/118.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636496 | Das et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Suman Das (Atlanta, Georgia); John W. Halloran (Ann Arbor, Michigan) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Suman Das (Atlanta, Georgia); John W. Halloran (Ann Arbor, Michigan) |
| ABSTRACT | Systems and methods for fabricating three-dimensional objects. The system includes an optical imaging system providing a light source; a photosensitive medium adapted to change states upon exposure to a portion of the light source from the optical imaging system; a control system for controlling movement of the optical imaging system, wherein the optical imaging system moves continuously above the photosensitive medium. The method includes moving a maskless optical imaging system providing the light beam in a continuous sequence; presenting the light beam on a portion of the photosensitive medium; lowering a plate upon which the photosensitive medium resides; and applying a new layer of the photosensitive medium. |
| FILED | Tuesday, May 05, 2009 |
| APPL NO | 12/435776 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Plastic article or earthenware shaping or treating: Apparatus 425/174.400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636721 | Alam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hasan Alam (Germantown, Maryland); Peter Rhee (San Gabriel, California); Emily Rhee (San Gabriel, California) |
| ASSIGNEE(S) | Henry M. Jackson Foundation For The Advancement of Military Medicine, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Hasan Alam (Germantown, Maryland); Peter Rhee (San Gabriel, California); Emily Rhee (San Gabriel, California) |
| ABSTRACT | A manually operable pump for the effective removal of fluids to include blood, blood clots, fluid, and air from a body cavity of a subject is provided. The manually operable pump is adapted to be connect to a range of fluid conduits and is equipped with one-way valves that effectively permit flow of fluid through the pump in only one direction. The sensitivity of the one-way valves is such that when properly positioned, fluid can flow through the valves and out of the pump without manual compression of the pump and with the aid of gravity power alone. |
| FILED | Monday, November 22, 2004 |
| APPL NO | 10/595450 |
| ART UNIT | 3761 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery 64/541 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636860 | DiSalvo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Roberto DiSalvo (Madison, Alabama); H. Waite Dykes, Jr. (Huntsville, Alabama); Robin D. Rogers (Tuscaloosa, Alabama); Julia Shamshina (Tuscaloosa, Alabama); Marcin Smiglak (Bad Friedrichshall, Germany) |
| ASSIGNEE(S) | Streamline Automation, LLC (Huntsville, Alabama); The University of Alabama (Tuscaloosa, Alabama) |
| INVENTOR(S) | Roberto DiSalvo (Madison, Alabama); H. Waite Dykes, Jr. (Huntsville, Alabama); Robin D. Rogers (Tuscaloosa, Alabama); Julia Shamshina (Tuscaloosa, Alabama); Marcin Smiglak (Bad Friedrichshall, Germany) |
| ABSTRACT | An energetic ionic liquid catalytic decomposition gas generator uses stoichiometric and nonstoiciometric mixtures of specific energetic ionic liquids and iridium catalyst. The catalyst temperature used and gas production versus ignition may be controlled by combining one or more cationic species with one or more anionic species of the ionic liquid(s). |
| FILED | Wednesday, December 01, 2010 |
| APPL NO | 12/958022 |
| ART UNIT | 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Explosive and thermic compositions or charges 149/1 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636861 | Stec, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Daniel Stec, III (Long Valley, New Jersey); Amy Wilson (Blairstown, New Jersey); Brian E. Fuchs (Hackettstown, New Jersey); Neha Mehta (Succasunna, New Jersey); Paula Cook (Succasunna, New Jersey) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Daniel Stec, III (Long Valley, New Jersey); Amy Wilson (Blairstown, New Jersey); Brian E. Fuchs (Hackettstown, New Jersey); Neha Mehta (Succasunna, New Jersey); Paula Cook (Succasunna, New Jersey) |
| ABSTRACT | Secondary crystalline high explosives are disclosed which are suitable for filling very small volume loading holes in micro-electric initiators for micro-electro-mechanical mechanisms (MEMS), used as safe and arm (S&A) devices. The explosives are prepared by adding the such a high explosive to an aqueous first volatile mobile phase, adding such a high explosive to a non-aqueous second volatile mobile phase, mixing the first and second volatile mobile phases and then loading the combined phases into the MEMS device and allowing the aqueous and non-aqueous solvents to evaporate depositing the high explosive. Enhanced adhesion between the deposited high explosive and enhanced rheological properties can be obtained by adding a polymeric binder to both mobile phases. |
| FILED | Wednesday, December 29, 2010 |
| APPL NO | 12/980571 |
| ART UNIT | 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Explosive and thermic compositions or charges 149/92 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637013 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yang Liu (Ann Arbor, Michigan); Pan Zheng (Ann Arbor, Michigan); Guo-Yun Chen (Ann Arbor, Michigan); Xincheng Zheng (Ann Arbor, Michigan); Xi Cheng (Woodland, California); Steve Kunkel (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Yang Liu (Ann Arbor, Michigan); Pan Zheng (Ann Arbor, Michigan); Guo-Yun Chen (Ann Arbor, Michigan); Xincheng Zheng (Ann Arbor, Michigan); Xi Cheng (Woodland, California); Steve Kunkel (Ann Arbor, Michigan) |
| ABSTRACT | The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient. |
| FILED | Wednesday, March 21, 2012 |
| APPL NO | 13/426392 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/130.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637041 | Guerry-Kopecko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Patricia Guerry-Kopecko (Silver Spring, Maryland); Shahida Baqar (Olney, Maryland) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Patricia Guerry-Kopecko (Silver Spring, Maryland); Shahida Baqar (Olney, Maryland) |
| ABSTRACT | The invention relates to an immunogenic composition composed of secreted polypeptides derived from Campylobacter jejuni non-flagellar proteins that are coordinately expressed with the flagellar regulon. The invention also relates to a method of inducing an immune response to the non-flagellar protein polypeptides. |
| FILED | Tuesday, June 19, 2012 |
| APPL NO | 13/526610 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/185.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637137 | Joseph et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paul Jayachandran Joseph (Atlanta, Georgia); Paul A. Kohl (Atlanta, Georgia); Sue Ann Bidstrup Allen (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Paul Jayachandran Joseph (Atlanta, Georgia); Paul A. Kohl (Atlanta, Georgia); Sue Ann Bidstrup Allen (Atlanta, Georgia) |
| ABSTRACT | Microstructures and methods of fabricating microstructures are disclosed. One exemplary microstructure, among others, includes a substrate, an overcoat layer disposed upon the substrate, an air-region within at least a portion of the overcoat layer, and a framing material layer engaging at least a portion of the air-region on the inside of the framing material layer and engaging the overcoat layer on the outside of the framing material layer. |
| FILED | Thursday, January 25, 2007 |
| APPL NO | 11/657769 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Stock material or miscellaneous articles 428/161 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637162 | Zabinski |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeffrey S. Zabinski (Yellow Springs, Ohio) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Jeffrey S. Zabinski (Yellow Springs, Ohio) |
| ABSTRACT | A method and class of bond coat is provided that physically and chemically bonds solid layer lubricants and other functional coatings to a substrate by burnishing, for example, selected soft materials, including oxides such as antimony trioxide, against the substrate. The new method and bond coat is a major improvement over conventional bonding or coating methods. The process is non-vacuum at ambient temperatures, requiring no binders, adhesives, curing or baking. Lubricant performance can be enhanced by orders of magnitude compared to when the bond coat and burnishing process are not applied. The method is inexpensive, environmentally friendly, applicable to any substrate material, and scalable. |
| FILED | Tuesday, March 31, 2009 |
| APPL NO | 12/741282 |
| ART UNIT | 1784 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Stock material or miscellaneous articles 428/615 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637231 | Van Dyke |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mark E. Van Dyke (Winston Salem, North Carolina) |
| ASSIGNEE(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| INVENTOR(S) | Mark E. Van Dyke (Winston Salem, North Carolina) |
| ABSTRACT | A liquid plasma expander or resuscitation fluid composition for use in a subject in need thereof, comprising, consisting of, or consisting essentially of: (a) a keratin derivative (preferably alpha keratose, gamma keratose, or combinations thereof, and with basic alpha keratose preferred over acidic alpha keratose); and (b) an electrolyte solution, with the keratin derivative solubilized in the electrolyte solution to form a homogeneous liquid composition. Blood substitutes formed therefrom and methods of making and using the same are also described. |
| FILED | Thursday, August 11, 2011 |
| APPL NO | 13/207992 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/1.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637265 | Navari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rudolph M. Navari (Granger, Indiana); Mary Prorok (South Bend, Indiana); Francis J. Castellino (Granger, Indiana) |
| ASSIGNEE(S) | University of Notre Dame (Notre Dame, Indiana) |
| INVENTOR(S) | Rudolph M. Navari (Granger, Indiana); Mary Prorok (South Bend, Indiana); Francis J. Castellino (Granger, Indiana) |
| ABSTRACT | Elevated levels of cathepsin E (catE) are demonstrated to be diagnostic of intestinal forms of cancer, such as colorectal cancer. Elevated levels of cathepsin E (catE, monomeric forms) are demonstrated to be detectable in the urine of animals having colorectal cancer, and a diagnostic/screening method for identifying and/or detecting colorectal cancer in an animal from a urine sample is provided. Specific tissue immunohistochemcial staining for catE (monomeric forms) in dysplastic tissue is also disclosed, and is shown to correlate with the level of dysplastic lesion severity. Hence, a method for identifying and determining the level of dysplastic lesion severity is provided. Cathepsin E mRNA transcription and expression levels are also demonstrated to be upregulated in dysplastic tissue, relative to non-dysplastic tissue. Hence, a method for transcriptionally profiling an animal to monitor the progression of colorectal disease is provided. |
| FILED | Tuesday, December 28, 2010 |
| APPL NO | 12/979889 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.230 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637267 | Keiler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kenneth C. Keiler (Boalsburg, Pennsylvania); Stephen J. Benkovic (State College, Pennsylvania) |
| ASSIGNEE(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| INVENTOR(S) | Kenneth C. Keiler (Boalsburg, Pennsylvania); Stephen J. Benkovic (State College, Pennsylvania) |
| ABSTRACT | Inhibitors of the tmRNA pathway have antibacterial activity with broad species specificity, including B. anthracis and other pathogens of military and civilian interest. Identified cyclic or linear peptides are further selected by in vivo selection methods, kill bacterial pathogens when added exogenously, and/or eliminate plasmids carrying antibiotic resistance or virulence genes. The molecular target of each cyclic peptide is in the tmRNA pathway and the tmRNA pathway is inhibited in vitro and in vivo by the addition of the peptides. |
| FILED | Monday, April 28, 2008 |
| APPL NO | 12/111096 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/8 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637270 | Kidwell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David A Kidwell (Alexandria, Virginia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | David A Kidwell (Alexandria, Virginia) |
| ABSTRACT | The present invention is generally directed to a fluidized bed detector for continuous detection of biological and chemical materials comprising a fluidized bed of detecting elements suspended in a continuous flow system wherein the detecting elements remain in the system when a first force trying to move the detecting elements to the bottom of the system is balanced with a second opposing force of a flowing gas or liquid trying to move detecting elements to the top of the system and wherein the presence of a target molecule in the flowing gas or liquid disrupts the balance of the first and second forces causing the detecting element to exit the system. The release of the detecting element indicates the presence of the target molecule and may be captured, concentrated, or both for further evaluation by other assays or other means. Also disclosed is the related method of detecting biological and chemical materials using a fluidized bed detector. |
| FILED | Friday, November 13, 2009 |
| APPL NO | 12/618180 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/29 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637303 | Lapota et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David Lapota (San Diego, California); Bryan Travis Bjorndal (Carlsbad, California); Gregory Wayne Anderson (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | David Lapota (San Diego, California); Bryan Travis Bjorndal (Carlsbad, California); Gregory Wayne Anderson (San Diego, California) |
| ABSTRACT | A system for assessing the characteristics and toxicity of a water sample comprising: a test chamber; an optical signal generator configured to emit an optical signal into the test chamber; a first digital filter disposed between the optical signal generator and the test chamber; a first optical transducer disposed to generate a first data signal in response to detecting radiant energy in the test chamber; a second digital filter disposed between the first optical transducer and the test chamber; an aqueous suspension of dinoflagellates contained within the test chamber and mixed with the water sample; a stimulator disposed to stimulate the dinoflagellates to emit a bioluminescence signal; and a microprocessor operatively coupled to the optical signal generator, the first digital optical filter, the stimulator, the first optical transducer, and the second digital filter, wherein the microprocessor is configured to assess the spectral characteristics and toxicity of the water sample. |
| FILED | Thursday, May 12, 2011 |
| APPL NO | 13/106695 |
| ART UNIT | 1775 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/288.700 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637344 | Kummel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Andrew C. Kummel (San Diego, California); Jeongwon Park (Palo Alto, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andrew C. Kummel (San Diego, California); Jeongwon Park (Palo Alto, California) |
| ABSTRACT | A method for forming a thin film electrode for an organic thin film transistor of the invention provides a multi-layer mask on a substrate with an electrode area opening in a top layer of the mask that is undercut by openings in other layers of the mask. A thin film of metal is deposited in the electrode area on the substrate. Removing the multi-layer mask leaves a well-formed thin film electrode with naturally tapered edges. A preferred embodiment of the invention is a method for forming a thin film electrode for an organic thin film transistor. The method includes depositing a first layer of photoresist on a substrate. The photoresist of the first layer has a first etching rate. A second layer of photoresist is deposited on the first layer of photoresist. The photoresist of the second layer has a second etching rate that is lower than the first etching rate. The first and second layer of photoresist are patterned by exposure. Developing the first and second layers of photoresist provides an electrode area on the substrate. An electrode is deposited in the electrode area. Lift-off of the first and second layers is performed. The electrode that is deposited has a tailored, tapered edge. A preferred embodiment thin film electrode in an organic thin film transistor has a tapered edge with a contact angle of approximately +40±4.4°. |
| FILED | Tuesday, April 21, 2009 |
| APPL NO | 12/936586 |
| ART UNIT | 2815 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/99 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637361 | Appenzeller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Joerg Appenzeller (Valhalla, New York); Supratik Guha (Chappaqua, New York); Emanuel Tutuc (Yorktown Heights, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Joerg Appenzeller (Valhalla, New York); Supratik Guha (Chappaqua, New York); Emanuel Tutuc (Yorktown Heights, New York) |
| ABSTRACT | A semiconductor structure is provided, which includes multiple sections arranged along a longitudinal axis. Preferably, the semiconductor structure comprises a middle section and two terminal sections located at opposite ends of the middle section. A semiconductor core having a first dopant concentration preferably extends along the longitudinal axis through the middle section and the two terminal sections. A semiconductor shell having a second, higher dopant concentration preferably encircles a portion of the semiconductor core at the two terminal sections, but not at the middle section, of the semiconductor structure. It is particularly preferred that the semiconductor structure is a nanostructure having a cross-sectional dimension of not more than 100 nm. |
| FILED | Monday, March 07, 2011 |
| APPL NO | 13/041740 |
| ART UNIT | 2893 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/197 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637386 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Qingchun Zhang (Cary, North Carolina); Anant K. Agarwal (Chapel Hill, North Carolina); Tangali S. Sudarshan (Columbia, South Carolina); Alexander Bolotnikov (Niskayuna, New York) |
| ASSIGNEE(S) | Cree, Inc. (Durham, North Carolina) |
| INVENTOR(S) | Qingchun Zhang (Cary, North Carolina); Anant K. Agarwal (Chapel Hill, North Carolina); Tangali S. Sudarshan (Columbia, South Carolina); Alexander Bolotnikov (Niskayuna, New York) |
| ABSTRACT | An electronic device includes a silicon carbide layer having a first conductivity type and a main junction adjacent a surface of the silicon carbide layer, and a junction termination region at the surface of the silicon carbide layer adjacent the main junction. Charge in the junction termination region decreases with lateral distance from the main junction, and a maximum charge in the junction termination region may be less than about 2×1014 cm−2. |
| FILED | Monday, March 08, 2010 |
| APPL NO | 12/719497 |
| ART UNIT | 2813 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/558 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637635 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lianglin Zhang (La Jolla, California); Jason A. Hoffman (La Jolla, California); Erkki Ruoslahti (Buellton, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lianglin Zhang (La Jolla, California); Jason A. Hoffman (La Jolla, California); Erkki Ruoslahti (Buellton, California) |
| ABSTRACT | The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treating any of a varirty of cardiovascular diseases as described below. Thus, the present invention provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CRPPR (SEQ ID NO: 1) or a peptidomimetic thereof. The invention further provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CARPAR (SEQ ID NO: 5) or a peptidomimetic thereof, or amino acid sequence CPKRPR (SEQ ID NO: 6) or a peptidomimtic thereof. |
| FILED | Thursday, January 29, 2009 |
| APPL NO | 12/322371 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637848 | Preble et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kyma Technologies, Inc. (Raleigh, North Carolina) |
| ASSIGNEE(S) | Kyma Technologies, Inc. (Raleigh, North Carolina) |
| INVENTOR(S) | Edward Preble (Raleigh, North Carolina); Lianghong Liu (Raleigh, North Carolina); Andrew D. Hanser (Saint Paul, Minnesota); N. Mark Williams (Raleigh, North Carolina); Xueping Xu (Stamford, Connecticut) |
| ABSTRACT | In a method for making a GaN article, an epitaxial nitride layer is deposited on a single-crystal substrate. A 3D nucleation GaN layer is grown on the epitaxial nitride layer by HVPE under a substantially 3D growth mode. A GaN transitional layer is grown on the 3D nucleation layer by HVPE under a condition that changes the growth mode from the substantially 3D growth mode to a substantially 2D growth mode. A bulk GaN layer is grown on the transitional layer by HVPE under the substantially 2D growth mode. A polycrystalline GaN layer is grown on the bulk GaN layer to form a GaN/substrate bi-layer. The GaN/substrate bi-layer may be cooled from the growth temperature to an ambient temperature, wherein GaN material cracks laterally and separates from the substrate, forming a free-standing article. |
| FILED | Thursday, December 06, 2012 |
| APPL NO | 13/706920 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/21 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637875 | Finkelstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hod Finkelstein (El Cerrito, California); Sadik C. Esener (Solana Beach, California); Yu-Hwa Lo (San Diego, California); Kai Zhao (Fishkill, New York); James Cheng (La Jolla, California); Sifang You (La Jolla, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Hod Finkelstein (El Cerrito, California); Sadik C. Esener (Solana Beach, California); Yu-Hwa Lo (San Diego, California); Kai Zhao (Fishkill, New York); James Cheng (La Jolla, California); Sifang You (La Jolla, California) |
| ABSTRACT | Apparatuses and systems for photon detection can include a first optical sensing structure structured to absorb light at a first optical wavelength; and a second optical sensing structure engaged with the first optical sensing structure to allow optical communication between the first and the second optical sensing structures. The second optical sensing structure can be structured to absorb light at a second optical wavelength longer than the first optical wavelength and to emit light at the first optical wavelength which is absorbed by the first optical sensing structure. Apparatuses and systems can include a bandgap grading region. |
| FILED | Monday, July 13, 2009 |
| APPL NO | 12/502225 |
| ART UNIT | 2893 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/84 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637901 | Zheleva et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tsvetanka Zheleva (Rockville, Maryland); Shah Pankaj (Rockville, Maryland); Michael Derenge (Columbia, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Tsvetanka Zheleva (Rockville, Maryland); Shah Pankaj (Rockville, Maryland); Michael Derenge (Columbia, Maryland) |
| ABSTRACT | A low-defect gallium nitride structure including a first gallium nitride layer comprising a plurality of gallium nitride columns etched into the first gallium nitride layer and a first dislocation density; and a second gallium nitride layer that extends over the gallium nitride columns and comprises a second dislocation density, wherein the second dislocation density may be lower than the first dislocation density. In addition, a method for fabricating a gallium nitride semiconductor layer that includes masking an underlying gallium nitride layer with a mask that comprises an array of columns and growing the underlying gallium nitride layer through the columns and onto said mask using metal-organic chemical vapor deposition pendeo-epitaxy to thereby form a pendeo-epitaxial gallium nitride layer coalesced on said mask to form a continuous pendeo-epitaxial monocrystalline gallium nitride semiconductor layer. |
| FILED | Tuesday, August 07, 2012 |
| APPL NO | 13/568362 |
| ART UNIT | 2891 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/189 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638011 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Philip T. Robinson (Harvard, Massachusetts); Seth M. Dziengeleski (Southbridge, Massachusetts); James D. Kazmierczak (Marlborough, Massachusetts); David J. Holigan (Atkinson, New Hampshire) |
| ASSIGNEE(S) | Protonex Technology Corporation (Southborough, Massachusetts) |
| INVENTOR(S) | Philip T. Robinson (Harvard, Massachusetts); Seth M. Dziengeleski (Southbridge, Massachusetts); James D. Kazmierczak (Marlborough, Massachusetts); David J. Holigan (Atkinson, New Hampshire) |
| ABSTRACT | Various aspects of invention provide portable power manager operating methods. One aspect of the invention provides a method for operating a power manager having a plurality of device ports for connecting with external power devices and a power bus for connecting with each device port. The method includes: disconnecting each device port from the power bus when no external power device is connected to the device port; accessing information from newly connected external power devices; determining if the newly connected external power devices can be connected to the power bus without power conversion; if not, determining if the newly connected external power devices can be connected to the power bus over an available power converter; and if so, configuring the available power converter for suitable power conversion. |
| FILED | Tuesday, June 15, 2010 |
| APPL NO | 12/816080 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Electrical transmission or interconnection systems 37/115 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638217 | Arms et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Steven W. Arms (Williston, Vermont); Chris Pruyn Townsend (Shelburne, Vermont); David Lawrence Churchill (Burlington, Vermont); Michael John Hamel (Essex Junction, Vermont) |
| ASSIGNEE(S) | Lord Corporation (Cary, North Carolina) |
| INVENTOR(S) | Steven W. Arms (Williston, Vermont); Chris Pruyn Townsend (Shelburne, Vermont); David Lawrence Churchill (Burlington, Vermont); Michael John Hamel (Essex Junction, Vermont) |
| ABSTRACT | A system comprises a sensing node that includes a sensor, a processor, an energy harvesting circuit, a time keeper, a first energy storage device, and a second energy storage device. The energy harvesting circuit is connected for recharging the first energy storage device. The processor is connected for receiving all its power derived from the energy harvesting circuit. The second energy storage device is connected for powering the time keeper. |
| FILED | Friday, March 12, 2010 |
| APPL NO | 12/723284 |
| ART UNIT | 2687 — Dynamic Storage Systems; Mechanical parts of Disk Drives |
| CURRENT CPC | Communications: Electrical 340/539.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638587 | De Brosse et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | John K. De Brosse (Colchester, Vermont); William J. Gallagher (Ardsley, New York); Yu Lu (Ridgefield, Connecticut) |
| ABSTRACT | In one embodiment, the invention is a magnetic shift register memory device. One embodiment of a memory cell includes a magnetic column including a plurality of magnetic domains, a reader coupled to the magnetic column, for reading data from the magnetic domains, a temporary memory for storing data read from the magnetic domains, and a writer coupled to the magnetic column, for writing data in the temporary memory to the magnetic domains. |
| FILED | Friday, August 02, 2013 |
| APPL NO | 13/957937 |
| ART UNIT | 2824 — Semiconductors/Memory |
| CURRENT CPC | Static information storage and retrieval 365/81 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638890 | Kumar |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rajendra Kumar (Cerritos, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Rajendra Kumar (Cerritos, California) |
| ABSTRACT | A receiver may comprise a complex mixer for converting the modulated signal to a complex modulated signal comprising a first in-phase component and a first quadrature component. The receiver may further comprise a digital demodulator. The digital demodulator may comprise at least one processor circuit programmed for applying a phase differencer for generating an output function in terms of a phase difference of the complex modulated signal. Applying the phase differencer may comprise converting the first in-phase component to a function of a phase difference of the first in-phase component expressed in digital time, and converting the first quadrature component to a function of the phase difference of the first quadrature component expressed in digital time. The at least one processor circuit of the digital demodulator may also be programmed for applying a four quadrant inverse tangent to the output function to generate the information signal. |
| FILED | Monday, May 07, 2012 |
| APPL NO | 13/465606 |
| ART UNIT | 2633 — Digital Communications |
| CURRENT CPC | Pulse or digital communications 375/346 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638963 | Parkins |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John W. Parkins (Ithaca, New York) |
| ASSIGNEE(S) | Red Tail Hawk Corporation (Ithaca, New York) |
| INVENTOR(S) | John W. Parkins (Ithaca, New York) |
| ABSTRACT | A hearing protection system with talk-through having a pair of rigid earcups enclosing a microphone, amplifier and speaker. A concha simulator, having a volume simulating that of the concha of a human ear, is acoustically coupled to the microphone, and also to the outside through an opening in the earcup. By coupling the microphone to the concha simulator, instead of directly to the outside, the acoustic response of the talk-through more accurately represents the hearing of a user. |
| FILED | Friday, May 28, 2010 |
| APPL NO | 12/789942 |
| ART UNIT | 2832 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Electrical audio signal processing systems and devices 381/322 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639055 | Hou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Weilin Hou (Slidell, Louisiana); Alan D. Weidemann (Carriere, Mississippi) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Weilin Hou (Slidell, Louisiana); Alan D. Weidemann (Carriere, Mississippi) |
| ABSTRACT | A method for calculating an image quality metric for evaluating the quality of a digital image including the steps of denoising the data of the image, identifying edges in the denoised data, determining an edge profile of the edges, determining a grayscale angle for each identified edge in the edge profile that is associated with the edge, and calculating the image quality metric based on a weighted average of the grayscale angles for all the edges. |
| FILED | Thursday, April 04, 2013 |
| APPL NO | 13/856487 |
| ART UNIT | 2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Image analysis 382/266 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639065 | Feng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ning-Ning Feng (Arcadia, California); Shirong Liao (Mira Loma, California); Dawei Zheng (Arcadia, California); Dazeng Feng (El Monte, California) |
| ASSIGNEE(S) | Kotura, Inc. (Monterey Park, California) |
| INVENTOR(S) | Ning-Ning Feng (Arcadia, California); Shirong Liao (Mira Loma, California); Dawei Zheng (Arcadia, California); Dazeng Feng (El Monte, California) |
| ABSTRACT | The system includes a light-transmitting medium positioned on a base. The light-transmitting medium included a ridge and a slab region. The ridge extends upward from the slab region and defines a portion of a waveguide on the base. The waveguide is configured to guide a light signal through the device. The device also includes an avalanche effect light sensor positioned on the base and configured to detect the presence of the light signal. The light sensor includes a light-absorbing medium positioned on the ridge of the light-transmitting medium such that the light signal is coupled from the light-transmitting medium into the light-absorbing medium. The light-transmitting includes a charge layer located at an interface of the light-transmitting medium and the light-absorbing medium. A multiplication region is formed in the slab regions of the light-transmitting medium such that the multiplication region receives charge carriers from the charge layer during the operation of the light sensor. |
| FILED | Friday, June 18, 2010 |
| APPL NO | 12/803136 |
| ART UNIT | 2883 — Optics |
| CURRENT CPC | Optical waveguides 385/12 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639312 | Clark et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Gregory Arthur Clark (Salt Lake City, Utah); David J. Warren (Salt Lake City, Utah); Noah M. Ledbetter (Salt Lake City, Utah) |
| ASSIGNEE(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| INVENTOR(S) | Gregory Arthur Clark (Salt Lake City, Utah); David J. Warren (Salt Lake City, Utah); Noah M. Ledbetter (Salt Lake City, Utah) |
| ABSTRACT | A system and method for electrically shielding a physiological pathway from electrical noise is disclosed. The method includes the operation of implanting at least one signal microelectrode into a patient such that the signal microelectrode is proximate to the physiological pathway. An additional operation includes substantially enclosing the microelectrode and a section of the physiological pathway with an electrical shielding wrap. The electrical shielding wrap includes a plurality of holes that enable fluid communication of physiological fluids between an inside and outside of the wrap. |
| FILED | Thursday, December 10, 2009 |
| APPL NO | 12/635374 |
| ART UNIT | 3766 — Optics |
| CURRENT CPC | Surgery 6/378 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639453 | Qing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Xinlin Qing (Cupertino, California); Irene J. Li (Stanford, California); Chang Zhang (Santa Clara, California) |
| ASSIGNEE(S) | Acellent Technologies, Inc. (Sunnyvale, California) |
| INVENTOR(S) | Xinlin Qing (Cupertino, California); Irene J. Li (Stanford, California); Chang Zhang (Santa Clara, California) |
| ABSTRACT | A self-sufficient structural health monitoring system that can monitor a structure without need for external power input. Embodiments of the invention provide a structural health monitoring system with a power supply integrated within, so that the system relies on itself for operational power. Systems with such an on-board electrical power source, independent of an external power source (and in particular, independent of the power system(s) of the structure being monitored), are much more self-contained and self-sufficient. |
| FILED | Wednesday, November 25, 2009 |
| APPL NO | 12/626594 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/34 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639475 | Rikoski |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Richard Rikoski (Alameda, California) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Richard Rikoski (Alameda, California) |
| ABSTRACT | A system and method of signal detection from a given point, in which a radiative aperture, such as a sonar sensor, radar antenna, acoustic sensor, or the like, receives radiation from the point at more than one range. At each range, the signal incident on each point within the aperture is weighted by the cosine of the angle between a surface normal at the point on the aperture, and a vector from the point on the aperture to the given point. The physical size and shape of the aperture may also be changed to cause the aperture to subtend the same solid angle having the given point as the vertex, at each range. In this manner, the signal from the given point becomes aperture shape independent, facilitating object recognition and imaging. |
| FILED | Monday, May 18, 2009 |
| APPL NO | 12/454486 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/189 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639476 | Martell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Craig A. Martell (Spotsylvania, Virginia); John A. Lawton (King George, Virginia); David B. Hurley (Fredericksburg, Virginia) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Craig A. Martell (Spotsylvania, Virginia); John A. Lawton (King George, Virginia); David B. Hurley (Fredericksburg, Virginia) |
| ABSTRACT | A computer-implemented method is provided for generating the estimation of current position, velocity and acceleration state vectors and associated uncertainty estimation (covariance) of a boosting ballistic missile. The method includes constructing a state tensor of the projectile from a plurality of sensor measurements in Earth-Centered, Earth-Fixed (ECEF) coordinates; translating the state tensor to Cartesian coordinates as a transform state; determining a covariance matrix from the transform state; updating the transformed state as an updated transform state; and updating the covariance matrix as an updated covariance. The process can further include adjusting the covariance matrix by an approximate transition matrix and a process noise matrix. The noise matrix can be translated from a local noise matrix based on a propagation time-step, a scaling parameter, and a bias process noise level. A time-of-flight in the state tensor can be updated by smoothing from a launch event. |
| FILED | Tuesday, January 31, 2012 |
| APPL NO | 13/385465 |
| ART UNIT | 2864 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/196 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639510 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kai Yu (Pittsburgh, Pennsylvania); Rob A. Rutenbar (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Yu (Pittsburgh, Pennsylvania); Rob A. Rutenbar (Pittsburgh, Pennsylvania) |
| ABSTRACT | A hardware acoustic scoring unit for a speech recognition system and a method of operation thereof are provided. Rather than scoring all senones in an acoustic model used for the speech recognition system, acoustic scoring logic first scores a set of ciphones based on acoustic features for one frame of sampled speech. The acoustic scoring logic then scores senones associated with the N highest scored ciphones. In one embodiment, the number (N) is three. While the acoustic scoring logic scores the senones associated with the N highest scored ciphones, high score ciphone identification logic operates in parallel with the acoustic scoring unit to identify one or more additional ciphones that have scores greater than a threshold. Once the acoustic scoring unit finishes scoring the senones for the N highest scored ciphones, the acoustic scoring unit then scores senones associated with the one or more additional ciphones. |
| FILED | Monday, December 22, 2008 |
| APPL NO | 12/341160 |
| ART UNIT | 2657 — Linguistics, Speech Processing and Audio Compression |
| CURRENT CPC | Data processing: Speech signal processing, linguistics, language translation, and audio compression/decompression 74/256.600 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639955 | Bose et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Pradip Bose (New York, New York); Alper Buyuktosunoglu (White Plains, New York); Chen-Yong Cher (Port Chester, New York); Prabhakar N. Kudva (New York, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Pradip Bose (New York, New York); Alper Buyuktosunoglu (White Plains, New York); Chen-Yong Cher (Port Chester, New York); Prabhakar N. Kudva (New York, New York) |
| ABSTRACT | A system and method for controlling power and performance in a microprocessor system includes a monitoring and control system integrated into a microprocessor system. The monitoring and control system includes a hierarchical architecture having a plurality of layers. Each layer in the hierarchal architecture is responsive to commands from a higher level, and the commands provide instructions on operations and power distribution, such that the higher levels provide modes of operation and budgets to lower levels and the lower levels provide feedback to the higher levels to control and manage power usage in the microprocessor system both globally and locally. |
| FILED | Wednesday, November 09, 2011 |
| APPL NO | 13/292712 |
| ART UNIT | 2116 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Electrical computers and digital processing systems: Support 713/300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08640087 | Sabbouh |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marwan Sabbouh (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Marwan Sabbouh (Chelmsford, Massachusetts) |
| ABSTRACT | A method and a scripting paradigm for automatically integrating disparate information systems (e.g., web services and databases) within a given enterprise into a service-oriented architecture. A script writer generates a script using a scripting paradigm, and the resulting script automatically derives new data models, new ontological structures, new mappings, and a new web service that integrates disparate information systems. In addition to integrating disparate information systems, the scripts may be harvested to automate the metadata discovery and retrieval process. The scripting paradigm builds upon existing open-source scripting languages and is compatible with existing internet browsers, thus encouraging mass participation in the integration process. |
| FILED | Friday, December 07, 2007 |
| APPL NO | 12/000096 |
| ART UNIT | 2191 — Interprocess Communication and Software Development |
| CURRENT CPC | Data processing: Software development, installation, and management 717/106 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08640141 | Arimilli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ravi K. Arimilli (Austin, Texas); Satya P. Sharma (Austin, Texas); Randal C. Swanberg (Round Rock, Texas) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Ravi K. Arimilli (Austin, Texas); Satya P. Sharma (Austin, Texas); Randal C. Swanberg (Round Rock, Texas) |
| ABSTRACT | A wake-and-go mechanism is provided for a data processing system. When a thread is waiting for an event, rather than performing a series of get-and-compare sequences, the thread updates a wake-and-go array with a target address associated with the event. The wake-and-go mechanism may save the state of the thread in a hardware private array. The hardware private array may comprise a plurality of memory cells embodied within the processor or pervasive logic associated with the bus, for example. Alternatively, the hardware private array may be embodied within logic associated with the wake-and-go storage array. |
| FILED | Friday, February 01, 2008 |
| APPL NO | 12/024705 |
| ART UNIT | 2196 — Interprocess Communication and Software Development |
| CURRENT CPC | Electrical computers and digital processing systems: Virtual machine task or process management or task management/control 718/108 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08640142 | Arimilli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ravi K. Arimilli (Austin, Texas); Satya P. Sharma (Austin, Texas); Randal C. Swanberg (Round Rock, Texas) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Ravi K. Arimilli (Austin, Texas); Satya P. Sharma (Austin, Texas); Randal C. Swanberg (Round Rock, Texas) |
| ABSTRACT | A wake-and-go mechanism is provided for a data processing system. When a thread first starts executing, a wake-and-go mechanism automatically allocates space for thread state in a hardware private array and space for a target address and other information, if any, in a wake-and-go array. If the hardware private array comprises a reserved portion of system memory, then the wake-and-go mechanism may request a sufficient portion of memory to store thread state for the thread. When a thread is waiting for an event, rather than performing a series of get-and-compare sequences, the thread updates a wake-and-go array with a target address associated with the event. The thread then goes to sleep until the event occurs. When a thread ends execution and is no longer in the run queue of the processor, the wake-and-go mechanism de-allocates the space for the thread state information for that thread. |
| FILED | Monday, June 23, 2008 |
| APPL NO | 12/144011 |
| ART UNIT | 2196 — Interprocess Communication and Software Development |
| CURRENT CPC | Electrical computers and digital processing systems: Virtual machine task or process management or task management/control 718/108 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08640147 | Park et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yoonho Park (Hawthorne, New York); Philippe L. Selo (Hawthorne, New York); Chitra Venkatramani (Hawthorne, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Yoonho Park (Hawthorne, New York); Philippe L. Selo (Hawthorne, New York); Chitra Venkatramani (Hawthorne, New York) |
| ABSTRACT | A method, system and computer program product of setting up a virtual connection at run time. The method includes the steps of: analyzing a topology of an application to determine at least one port pair where the port pair comprises an output port of a first operator and an input port of a second operator; configuring a first auxiliary operator to receive data from a first operator; configuring a second auxiliary operator to send data to a second operator; deploying the first operator, the second operator, the first auxiliary operator and the second auxiliary operator; receiving a function address of the second auxiliary operator; and sending the function address of the second auxiliary operator to a first destination; where at least one of the steps is carried out using a computer device so that the virtual connection is setup at run time. |
| FILED | Thursday, November 11, 2010 |
| APPL NO | 12/944246 |
| ART UNIT | 2194 — Interprocess Communication and Software Development |
| CURRENT CPC | Electrical computers and digital processing systems: Interprogram communication or interprocess communication 719/320 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08640189 | Ernst et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Richard J. Ernst (Rowlett, Texas); James H. Swedberg (Richardson, Texas); Matthew J. Hicks (Dallas, Texas); Herbert T. Riggs, III (Grasonville, Maryland); Matt A. Powers (Farmers Branch, Texas); Jason E. Ostermann (Plano, Texas) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Richard J. Ernst (Rowlett, Texas); James H. Swedberg (Richardson, Texas); Matthew J. Hicks (Dallas, Texas); Herbert T. Riggs, III (Grasonville, Maryland); Matt A. Powers (Farmers Branch, Texas); Jason E. Ostermann (Plano, Texas) |
| ABSTRACT | In certain embodiments, a method includes receiving from a validation system a request to apply a first policy service to a message. The validation system determines whether the message may be transmitted to a second network by validating a plurality of tokens associated with the message. The method includes receiving at least one result from a policy service engine of applying the first policy service to the message and determining at least one predefined assertion based on the received at least one result. The message includes generating a first token by encrypting the at least one predefined assertion using a first parameter associated with the first service node and not the second service node. The method includes sending the message and the first token to the validation system. |
| FILED | Monday, March 07, 2011 |
| APPL NO | 13/042367 |
| ART UNIT | 2433 — Cryptography and Security |
| CURRENT CPC | Information security 726/1 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 08635850 | Light et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Max E. Light (Los Alamos, New Mexico); Patrick L. Colestock (Santa Fe, New Mexico) |
| ASSIGNEE(S) | U.S. Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Max E. Light (Los Alamos, New Mexico); Patrick L. Colestock (Santa Fe, New Mexico) |
| ABSTRACT | An electron cyclotron resonance (ECR) thruster is disclosed having a plasma chamber which is electrically biased with a positive voltage. The chamber bias serves to efficiently accelerate and expel the positive ions from the chamber. Electrons follow the exiting ions, serving to provide an electrically neutral exhaust plume. In a further embodiment, a downstream shaping magnetic field serves to further accelerate and/or shape the exhaust plume. |
| FILED | Friday, August 29, 2008 |
| APPL NO | 12/201071 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Power plants 060/202 |
| VIEW PATENT | @ USPTO: Full Text PDF |
08636085 — Methods and apparatus for removal and control of material in laser drilling of a borehole
| US 08636085 | Rinzler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Charles C. Rinzler (Denver, Colorado); Mark S. Zediker (Weldon Spring, Missouri); Brian O. Faircloth (Evergreen, Colorado); Joel F. Moxley (Denver, Colorado) |
| ASSIGNEE(S) | Foro Energy, Inc. (Littleton, Colorado) |
| INVENTOR(S) | Charles C. Rinzler (Denver, Colorado); Mark S. Zediker (Weldon Spring, Missouri); Brian O. Faircloth (Evergreen, Colorado); Joel F. Moxley (Denver, Colorado) |
| ABSTRACT | The removal of material from the path of a high power laser beam during down hole laser operations including drilling of a borehole and removal of displaced laser effected borehole material from the borehole during laser operations. In particular, paths, dynamics and parameters of fluid flows for use in conjunction with a laser bottom hole assembly. |
| FILED | Wednesday, August 19, 2009 |
| APPL NO | 12/543968 |
| ART UNIT | 3676 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Boring or penetrating the earth 175/16 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636817 | Scotto et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mark Vincent Scotto (Uniontown, Ohio); Daniel P. Birmingham (Canton, Ohio); Crispin L. DeBellis (North Canton, Ohio); Mark Anthony Perna (Alliance, Ohio); Gregory C. Rush (Canton, Ohio) |
| ASSIGNEE(S) | Rolls-Royce Fuel Cell Systems (US) Inc. (North Canton, Ohio) |
| INVENTOR(S) | Mark Vincent Scotto (Uniontown, Ohio); Daniel P. Birmingham (Canton, Ohio); Crispin L. DeBellis (North Canton, Ohio); Mark Anthony Perna (Alliance, Ohio); Gregory C. Rush (Canton, Ohio) |
| ABSTRACT | The present invention provides a gas generator that may be used for startup and shutdown of a fuel cell. In one non-limiting embodiment, the gas generator may include a nitrogen generator structured to receive air, extract oxygen (O2) from the air and discharge the balance in the form of a nitrogen-rich gas; a merging chamber structured to receive a hydrocarbon fuel and the nitrogen-rich gas and to discharge a feed mixture containing both the hydrocarbon fuel and the nitrogen-rich gas; and a catalytic reactor structured to receive the feed mixture and to catalytically convert the feed mixture into a reducing gas. |
| FILED | Friday, September 04, 2009 |
| APPL NO | 12/554460 |
| ART UNIT | 1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Gas: Heating and illuminating 048/127.900 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636892 | Koehl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eugene R. Koehl (Joliet, Illinois); Laurel A. Barnes (Chicago, Illinois); Stanley G. Wiedmeyer (Glen Ellyn, Illinois); Mark A. Williamson (Naperville, Illinois); James L. Willit (Batavia, Illinois) |
| ASSIGNEE(S) | GE-Hitachi Nuclear Energy Americas LLC (Wilmington, North Carolina) |
| INVENTOR(S) | Eugene R. Koehl (Joliet, Illinois); Laurel A. Barnes (Chicago, Illinois); Stanley G. Wiedmeyer (Glen Ellyn, Illinois); Mark A. Williamson (Naperville, Illinois); James L. Willit (Batavia, Illinois) |
| ABSTRACT | Power distribution systems are useable in electrolytic reduction systems and include several cathode and anode assembly electrical contacts that permit flexible modular assembly numbers and placement in standardized connection configurations. Electrical contacts may be arranged at any position where assembly contact is desired. Electrical power may be provided via power cables attached to seating assemblies of the electrical contacts. Cathode and anode assembly electrical contacts may provide electrical power at any desired levels. Pairs of anode and cathode assembly electrical contacts may provide equal and opposite electrical power; different cathode assembly electrical contacts may provide different levels of electrical power to a same or different modular cathode assembly. Electrical systems may be used with an electrolyte container into which the modular cathode and anode assemblies extend and are supported above, with the modular cathode and anode assemblies mechanically and electrically connecting to the respective contacts in power distribution systems. |
| FILED | Thursday, December 23, 2010 |
| APPL NO | 12/977839 |
| ART UNIT | 1754 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Electrolysis: Processes, compositions used therein, and methods of preparing the compositions 25/560 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08636966 | Soderquist et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Chuck Z. Soderquist (Richland, Washington); Amanda M. Johnsen (Richland, Washington); Bruce K. McNamara (Richland, Washington); Brady D. Hanson (Richland, Washington); Steven C. Smith (Richland, Washington); Shane M. Peper (Richland, Washington) |
| ABSTRACT | Compositions are provided that include nuclear fuel. Methods for treating nuclear fuel are provided which can include exposing the fuel to a carbonate-peroxide solution. Methods can also include exposing the fuel to an ammonium solution. Methods for acquiring molybdenum from a uranium comprising material are provided. |
| FILED | Monday, August 12, 2013 |
| APPL NO | 13/964914 |
| ART UNIT | 1761 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Chemistry of inorganic compounds 423/54 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637193 | Steinbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Andrew J. L. Steinbach (Minneapolis, Minnesota); George D. Vernstrom (Cottage Grove, Minnesota); Mark K. Debe (Stillwater, Minnesota); Radoslav Atanasoski (Edina, Minnesota) |
| ASSIGNEE(S) | 3M Innovative Properties Company (St. Paul, Minnesota) |
| INVENTOR(S) | Andrew J. L. Steinbach (Minneapolis, Minnesota); George D. Vernstrom (Cottage Grove, Minnesota); Mark K. Debe (Stillwater, Minnesota); Radoslav Atanasoski (Edina, Minnesota) |
| ABSTRACT | In some embodiments, the present disclosure provides a fuel cell catalyst having a catalyst surface bearing a non-occluding layer of iridium. In some embodiments, the present disclosure provides a fuel cell catalyst comprising a catalyst surface bearing a sub-monolayer of iridium. In some embodiments, the present disclosure provides a fuel cell catalyst comprising a catalyst surface bearing a layer of iridium having a planar equivalent thickness of between 1 and 100 Angstroms. In some embodiments, the fuel cell catalyst comprises nanostructured elements comprising microstructured support whiskers bearing a thin film of nanoscopic catalyst particles. The layer of iridium typically has a planar equivalent thickness of between 1 and 100 Angstroms and more typically between 5 and 60 Angstroms. The fuel cell catalyst typically comprises no electrically conductive carbon material and typically comprises at least a portion of the iridium in the zero oxidation state. |
| FILED | Tuesday, August 25, 2009 |
| APPL NO | 12/546775 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemistry: Electrical current producing apparatus, product, and process 429/400 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637205 | Iverson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eric J. Iverson (Eau Claire, Wisconsin); Daniel M. Pierpont (North St. Paul, Minnesota); Michael A. Yandrasits (Hastings, Minnesota); Steven J. Hamrock (Stillwater, Minnesota); Stephan J. Obradovich (Menomonie, Wisconsin); Donald G. Peterson (Shoreview, Minnesota) |
| ASSIGNEE(S) | 3M Innovative Properties Company (St. Paul, Minnesota) |
| INVENTOR(S) | Eric J. Iverson (Eau Claire, Wisconsin); Daniel M. Pierpont (North St. Paul, Minnesota); Michael A. Yandrasits (Hastings, Minnesota); Steven J. Hamrock (Stillwater, Minnesota); Stephan J. Obradovich (Menomonie, Wisconsin); Donald G. Peterson (Shoreview, Minnesota) |
| ABSTRACT | A fuel cell roll good subassembly is described that includes a plurality of individual electrolyte membranes. One or more first subgaskets are attached to the individual electrolyte membranes. Each of the first subgaskets has at least one aperture and the first subgaskets are arranged so the center regions of the individual electrolyte membranes are exposed through the apertures of the first subgaskets. A second subgasket comprises a web having a plurality of apertures. The second subgasket web is attached to the one or more first subgaskets so the center regions of the individual electrolyte membranes are exposed through the apertures of the second subgasket web. The second subgasket web may have little or no adhesive on the subgasket surface facing the electrolyte membrane. |
| FILED | Monday, December 20, 2010 |
| APPL NO | 12/972959 |
| ART UNIT | 1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Chemistry: Electrical current producing apparatus, product, and process 429/480 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637209 | Jacobson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Allan J. Jacobson (Houston, Texas); Shuangyan Wang (Pearland, Texas); Gun Tae Kim (Ulsan, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Allan J. Jacobson (Houston, Texas); Shuangyan Wang (Pearland, Texas); Gun Tae Kim (Ulsan, South Korea) |
| ABSTRACT | Novel cathode, electrolyte and oxygen separation materials are disclosed that operate at intermediate temperatures for use in solid oxide fuel cells and ion transport membranes based on oxides with perovskite related structures and an ordered arrangement of A site cations. The materials have significantly faster oxygen kinetics than in corresponding disordered perovskites. |
| FILED | Wednesday, August 09, 2006 |
| APPL NO | 11/990295 |
| ART UNIT | 1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Chemistry: Electrical current producing apparatus, product, and process 429/532 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637293 | Adney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William S. Adney (Golden, Colorado); Michael E. Himmel (Littleton, Colorado); Stephen R. Decker (Berthoud, Colorado); Eric P. Knoshaug (Golden, Colorado); Mark R. Nimlos (Golden, Colorado); Michael F. Crowley (Lakewood, Colorado); Tina Jeoh (Davis, California) |
| ASSIGNEE(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | William S. Adney (Golden, Colorado); Michael E. Himmel (Littleton, Colorado); Stephen R. Decker (Berthoud, Colorado); Eric P. Knoshaug (Golden, Colorado); Mark R. Nimlos (Golden, Colorado); Michael F. Crowley (Lakewood, Colorado); Tina Jeoh (Davis, California) |
| ABSTRACT | Provided herein is an isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide, wherein the mutations reduce N-linked glycosylation of the isolated polypeptide relative to the wild type polypeptide. Also provided herein is an isolated Cel7A polypeptide comprising increased O-linked glycosylation of the linker domain relative to a linker domain of a wild type Cel7A polypeptide. The increased O-linked glycosylation is a result of the addition of and/or substitution of one or more serine and/or threonine residues to the linker domain relative to the linker domain of the wild type polypeptide. In some embodiments, the isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide further comprises increased O-linked glycosylation of the linker domain relative to a linker domain of a wild type Cel7A polypeptide. The mutations in the catalytic domain reduce N-linked glycosylation of the isolated polypeptide relative to the wild type polypeptide. The addition of and/or substitution of one or more serine and/or threonine residues to the linker domain relative to the linker domain of the wild type polypeptide increases O-linked glycosylation of the isolated polypeptide. Further provided are compositions comprising such polypeptides and nucleic acids encoding such polypeptides. Still further provided are methods for making such polypeptides. |
| FILED | Monday, May 19, 2008 |
| APPL NO | 12/123352 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/201 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637294 | Day et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Anthony Day (San Francisco, California); Frits Goedegebuur (Vlaardingen, Netherlands); Peter Gualfetti (San Francisco, California); Colin Mitchinson (Half Moon Bay, California); Paulien Neefe (Zoetermeer, Netherlands); Mats Sandgren (Uppsala, Sweden); Andrew Shaw (San Francisco, California); Jerry Stahlberg (Uppsala, Sweden) |
| ASSIGNEE(S) | Danisco US Inc. (Palo Alto, California) |
| INVENTOR(S) | Anthony Day (San Francisco, California); Frits Goedegebuur (Vlaardingen, Netherlands); Peter Gualfetti (San Francisco, California); Colin Mitchinson (Half Moon Bay, California); Paulien Neefe (Zoetermeer, Netherlands); Mats Sandgren (Uppsala, Sweden); Andrew Shaw (San Francisco, California); Jerry Stahlberg (Uppsala, Sweden) |
| ABSTRACT | Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility. |
| FILED | Thursday, March 22, 2007 |
| APPL NO | 11/728219 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/209 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637306 | Young et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Travis Young (San Diego, California); Peter G. Schultz (La Jolla, California) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Travis Young (San Diego, California); Peter G. Schultz (La Jolla, California) |
| ABSTRACT | Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods are also provided. In addition, orthogonal translation systems in methylotrophic yeast and methods of using these systems to produce carrier and target polypeptide variants comprising unnatural amino acids are provided. |
| FILED | Wednesday, December 09, 2009 |
| APPL NO | 12/653274 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/325 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637433 | Painter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas Painter (Tallahassee, Florida); Ting Xu (Knoxville, Tennessee); Xiaotao Liu (Raleigh, North Carolina) |
| ASSIGNEE(S) | Florida State University Technology Transfer Office (Tallahassee, Florida) |
| INVENTOR(S) | Thomas Painter (Tallahassee, Florida); Ting Xu (Knoxville, Tennessee); Xiaotao Liu (Raleigh, North Carolina) |
| ABSTRACT | A method for making a composite superconductor and a superconductor made using the method. Superconducting filaments are embedded in a matrix material. Oxygen-containing elements are also embedded in the matrix material, with the oxygen-containing elements preferably being dispersed evenly among the superconducting filaments. A surrounding reinforcement material contains the other elements and preferably seals the superconductor from the surrounding atmosphere. |
| FILED | Tuesday, October 04, 2011 |
| APPL NO | 13/252749 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Superconductor technology: Apparatus, material, process 55/492 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637813 | Van Berkel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gary J. Van Berkel (Clinton, Tennessee); Vilmos Kertesz (Knoxville, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Gary J. Van Berkel (Clinton, Tennessee); Vilmos Kertesz (Knoxville, Tennessee) |
| ABSTRACT | A system and method for laser desorption of an analyte from a specimen and capturing of the analyte in a suspended solvent to form a testing solution are described. The method can include providing a specimen supported by a desorption region of a specimen stage and desorbing an analyte from a target site of the specimen with a laser beam centered at a radiation wavelength (λ). The desorption region is transparent to the radiation wavelength (λ) and the sampling probe and a laser source emitting the laser beam are on opposite sides of a primary surface of the specimen stage. The system can also be arranged where the laser source and the sampling probe are on the same side of a primary surface of the specimen stage. The testing solution can then be analyzed using an analytical instrument or undergo further processing. |
| FILED | Friday, October 01, 2010 |
| APPL NO | 12/896018 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Radiant energy 250/288 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637996 | Frey |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ITN Energy Systems, Inc. (Littleton, Colorado) |
| ASSIGNEE(S) | ITN Energy Systems, Inc. (Littleton, Colorado) |
| INVENTOR(S) | Jonathan Frey (Denver, Colorado) |
| ABSTRACT | This disclosure describes systems and methods for increasing the usable surface area of electrical contacts within a device, such as a thin film solid state device, through the implementation of electrically conductive interconnects. Embodiments described herein include the use of a plurality of electrically conductive interconnects that penetrate through a top contact layer, through one or more multiple layers, and into a bottom contact layer. The plurality of conductive interconnects may form horizontal and vertical cross-sectional patterns. The use of lasers to form the plurality of electrically conductive interconnects from reflowed layer material further aids in the manufacturing process of a device. |
| FILED | Monday, December 17, 2012 |
| APPL NO | 13/717364 |
| ART UNIT | 2813 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/774 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638440 | Ohodnicki, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paul R. Ohodnicki, Jr. (Alison Park, Pennsylvania); Congjun Wang (Bethel Park, Pennsylvania); Mark A. Andio (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | U.S. Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Paul R. Ohodnicki, Jr. (Alison Park, Pennsylvania); Congjun Wang (Bethel Park, Pennsylvania); Mark A. Andio (Pittsburgh, Pennsylvania) |
| ABSTRACT | The disclosure relates to a method of detecting a change in a chemical composition by contacting a doped oxide material with a monitored stream, illuminating the doped oxide material with incident light, collecting exiting light, monitoring an optical signal based on a comparison of the incident light and the exiting light, and detecting a shift in the optical signal. The doped metal oxide has a carrier concentration of at least 1018/cm3, a bandgap of at least 2 eV, and an electronic conductivity of at least 101 S/cm, where parameters are specified at a temperature of 25° C. The optical response of the doped oxide materials results from the high carrier concentration of the doped metal oxide, and the resulting impact of changing gas atmospheres on that relatively high carrier concentration. These changes in effective carrier densities of conducting metal oxide nanoparticles are postulated to be responsible for the change in measured optical absorption associated with free carriers. Exemplary doped metal oxides include but are not limited to Al-doped ZnO, Sn-doped In2O3, Nb-doped TiO2, and F-doped SnO2. |
| FILED | Wednesday, June 26, 2013 |
| APPL NO | 13/927223 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Optics: Measuring and testing 356/437 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638900 | Altman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David A. Altman (Pittsburgh, Pennsylvania); David R. Forsyth (Cheswick, Pennsylvania); Richard E. Smith (Harrison City, Pennsylvania); Norman R. Singleton (Murrysville, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | David A. Altman (Pittsburgh, Pennsylvania); David R. Forsyth (Cheswick, Pennsylvania); Richard E. Smith (Harrison City, Pennsylvania); Norman R. Singleton (Murrysville, Pennsylvania) |
| ABSTRACT | An alignment plate that is attached to a core barrel of a pressurized water reactor and fits within slots within a top plate of a lower core shroud and upper core plate to maintain lateral alignment of the reactor internals. The alignment plate is connected to the core barrel through two vertically-spaced dowel pins that extend from the outside surface of the core barrel through a reinforcement pad and into corresponding holes in the alignment plate. Additionally, threaded fasteners are inserted around the perimeter of the reinforcement pad and into the alignment plate to further secure the alignment plate to the core barrel. A fillet weld also is deposited around the perimeter of the reinforcement pad. To accommodate thermal growth between the alignment plate and the core barrel, a gap is left above, below and at both sides of one of the dowel pins in the alignment plate holes through which the dowel pins pass. |
| FILED | Friday, September 14, 2007 |
| APPL NO | 11/855196 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Induced nuclear reactions: Processes, systems, and elements 376/353 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639392 | Chassin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David P. Chassin (Pasco, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | David P. Chassin (Pasco, Washington) |
| ABSTRACT | Disclosed herein are representative embodiments of methods, apparatus, and systems for distributing a resource (such as electricity) using a resource allocation system. In one exemplary embodiment, a plurality of requests for electricity are received from a plurality of end-use consumers. The requests indicate a requested quantity of electricity and a consumer-requested index value indicative of a maximum price a respective end-use consumer will pay for the requested quantity of electricity. A plurality of offers for supplying electricity are received from a plurality of resource suppliers. The offers indicate an offered quantity of electricity and a supplier-requested index value indicative of a minimum price for which a respective supplier will produce the offered quantity of electricity. A dispatched index value is computed at which electricity is to be supplied based at least in part on the consumer-requested index values and the supplier-requested index values. |
| FILED | Tuesday, September 29, 2009 |
| APPL NO | 12/587008 |
| ART UNIT | 2127 — AI & Simulation/Modeling |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/08 (20130101) G06Q 30/0611 (20130101) G06Q 50/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639449 | Weiss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Shimon Weiss (Los Angeles, California); Marcel Bruchez (Pittsburgh, Pennsylvania); Paul Alivisatos (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Shimon Weiss (Los Angeles, California); Marcel Bruchez (Pittsburgh, Pennsylvania); Paul Alivisatos (Oakland, California) |
| ABSTRACT | A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe. |
| FILED | Friday, April 29, 2011 |
| APPL NO | 13/097430 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/19 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08640070 | Asaad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sameh W Asaad (Briarcliff Manor, New York); Ralph E Bellofatto (Ridgefield, Connecticut); Bernard Brezzo (Somers, New York); Charles L Haymes (Fair Lawn, New Jersey); Mohit Kapur (Sleepy Hollow, New York); Benjamin D Parker (Peekskill, New York); Thomas Roewer (Danbury, Connecticut); Jose A Tierno (Stamford, Connecticut) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Sameh W Asaad (Briarcliff Manor, New York); Ralph E Bellofatto (Ridgefield, Connecticut); Bernard Brezzo (Somers, New York); Charles L Haymes (Fair Lawn, New Jersey); Mohit Kapur (Sleepy Hollow, New York); Benjamin D Parker (Peekskill, New York); Thomas Roewer (Danbury, Connecticut); Jose A Tierno (Stamford, Connecticut) |
| ABSTRACT | A plurality of target field programmable gate arrays are interconnected in accordance with a connection topology and map portions of a target system. A control module is coupled to the plurality of target field programmable gate arrays. A balanced clock distribution network is configured to distribute a reference clock signal, and a balanced reset distribution network is coupled to the control module and configured to distribute a reset signal to the plurality of target field programmable gate arrays. The control module and the balanced reset distribution network are cooperatively configured to initiate and control a simulation of the target system with the plurality of target field programmable gate arrays. A plurality of local clock control state machines reside in the target field programmable gate arrays. The local clock control state machines are coupled to the balanced clock distribution network and obtain the reference clock signal therefrom. The plurality of local clock control state machines are configured to generate a set of synchronized free-running and stoppable clocks to maintain cycle-accurate and cycle-reproducible execution of the simulation of the target system. A method is also provided. |
| FILED | Monday, November 08, 2010 |
| APPL NO | 12/941834 |
| ART UNIT | 2825 — Semiconductors/Memory |
| CURRENT CPC | Computer-aided design and analysis of circuits and semiconductor masks 716/116 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 08636906 | Stein |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Adam L. Stein (Venice, California) |
| ASSIGNEE(S) | Advantageous Systems, LLC (Pasadena, California) |
| INVENTOR(S) | Adam L. Stein (Venice, California) |
| ABSTRACT | Disclosed are magnetic nanoparticles and methods of using magnetic nanoparticles for selectively removing biologics, small molecules, analytes, ions, or other molecules of interest from liquids. |
| FILED | Monday, April 25, 2011 |
| APPL NO | 13/093315 |
| ART UNIT | 1778 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Liquid purification or separation 210/683 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637009 | Landry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Donald W. Landry (New York, New York); James H. Woods (Ann Arbor, Michigan); Roger K. Sunahara (Ann Arbor, Michigan); Diwahar L. Narasimhan (Ann Arbor, Michigan); Joanne MacDonald (New York, New York); Milan N. Stojanovich (Fort Lee, New Jersey); John J. Tesmer (Ann Arbor, Michigan); Remy L. Brim (Farmington Hills, Michigan) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Donald W. Landry (New York, New York); James H. Woods (Ann Arbor, Michigan); Roger K. Sunahara (Ann Arbor, Michigan); Diwahar L. Narasimhan (Ann Arbor, Michigan); Joanne MacDonald (New York, New York); Milan N. Stojanovich (Fort Lee, New Jersey); John J. Tesmer (Ann Arbor, Michigan); Remy L. Brim (Farmington Hills, Michigan) |
| ABSTRACT | Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition. |
| FILED | Thursday, July 10, 2008 |
| APPL NO | 12/667895 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/94.600 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637137 | Joseph et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paul Jayachandran Joseph (Atlanta, Georgia); Paul A. Kohl (Atlanta, Georgia); Sue Ann Bidstrup Allen (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Paul Jayachandran Joseph (Atlanta, Georgia); Paul A. Kohl (Atlanta, Georgia); Sue Ann Bidstrup Allen (Atlanta, Georgia) |
| ABSTRACT | Microstructures and methods of fabricating microstructures are disclosed. One exemplary microstructure, among others, includes a substrate, an overcoat layer disposed upon the substrate, an air-region within at least a portion of the overcoat layer, and a framing material layer engaging at least a portion of the air-region on the inside of the framing material layer and engaging the overcoat layer on the outside of the framing material layer. |
| FILED | Thursday, January 25, 2007 |
| APPL NO | 11/657769 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Stock material or miscellaneous articles 428/161 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637141 | Gemici et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zekeriyya Gemici (Cambridge, Massachusetts); Michael F. Rubner (Westford, Massachusetts); Robert E. Cohen (Jamaica Plain, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Zekeriyya Gemici (Cambridge, Massachusetts); Michael F. Rubner (Westford, Massachusetts); Robert E. Cohen (Jamaica Plain, Massachusetts) |
| ABSTRACT | A superhydrophilic coating can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can have a graded refractive index. The coating for wafer-level optics can be for targeted capillary condensation in nanoparticle containing reflow-compatible coatings. |
| FILED | Thursday, May 28, 2009 |
| APPL NO | 12/473803 |
| ART UNIT | 1781 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Stock material or miscellaneous articles 428/212 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637301 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeff Tza-Huei Wang (Baltimore, Maryland); Kelvin J. Liu (Baltimore, Maryland); Christopher M. Puleo (Glenville, New York); Tushar D. Rane (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jeff Tza-Huei Wang (Baltimore, Maryland); Kelvin J. Liu (Baltimore, Maryland); Christopher M. Puleo (Glenville, New York); Tushar D. Rane (Baltimore, Maryland) |
| ABSTRACT | A microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with the concentration section, and a detection region that is at least partially transparent to illumination light of the confocal fluorescence detection system and at least partially transparent to fluorescent light when emitted from a sample under observation as the sample flows through the detection region. |
| FILED | Tuesday, March 02, 2010 |
| APPL NO | 13/147742 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/283.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637344 | Kummel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Andrew C. Kummel (San Diego, California); Jeongwon Park (Palo Alto, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andrew C. Kummel (San Diego, California); Jeongwon Park (Palo Alto, California) |
| ABSTRACT | A method for forming a thin film electrode for an organic thin film transistor of the invention provides a multi-layer mask on a substrate with an electrode area opening in a top layer of the mask that is undercut by openings in other layers of the mask. A thin film of metal is deposited in the electrode area on the substrate. Removing the multi-layer mask leaves a well-formed thin film electrode with naturally tapered edges. A preferred embodiment of the invention is a method for forming a thin film electrode for an organic thin film transistor. The method includes depositing a first layer of photoresist on a substrate. The photoresist of the first layer has a first etching rate. A second layer of photoresist is deposited on the first layer of photoresist. The photoresist of the second layer has a second etching rate that is lower than the first etching rate. The first and second layer of photoresist are patterned by exposure. Developing the first and second layers of photoresist provides an electrode area on the substrate. An electrode is deposited in the electrode area. Lift-off of the first and second layers is performed. The electrode that is deposited has a tailored, tapered edge. A preferred embodiment thin film electrode in an organic thin film transistor has a tapered edge with a contact angle of approximately +40±4.4°. |
| FILED | Tuesday, April 21, 2009 |
| APPL NO | 12/936586 |
| ART UNIT | 2815 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/99 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637356 | Somu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sivasubramanian Somu (Boston, Massachusetts); Ahmed Busnaina (Ashland, Massachusetts); Nicol McGruer (Dover, Massachusetts); Peter Ryan (Waltham, Massachusetts); George G. Adams (West Newton, Massachusetts); Xugang Xiong (Boston, Massachusetts); Taehoon Kim (Boston, Massachusetts) |
| ASSIGNEE(S) | Northeastern University (Boston, Massachusetts) |
| INVENTOR(S) | Sivasubramanian Somu (Boston, Massachusetts); Ahmed Busnaina (Ashland, Massachusetts); Nicol McGruer (Dover, Massachusetts); Peter Ryan (Waltham, Massachusetts); George G. Adams (West Newton, Massachusetts); Xugang Xiong (Boston, Massachusetts); Taehoon Kim (Boston, Massachusetts) |
| ABSTRACT | A non-volatile bistable nano-electromechanical switch is provided for use in memory devices and microprocessors. The switch employs carbon nanotubes as the actuation element. A method has been developed for fabricating nanoswitches having one single-walled carbon nanotube as the actuator. The actuation of two different states can be achieved using the same low voltage for each state. |
| FILED | Wednesday, June 27, 2012 |
| APPL NO | 13/534105 |
| ART UNIT | 2812 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor device manufacturing: Process 438/151 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637433 | Painter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas Painter (Tallahassee, Florida); Ting Xu (Knoxville, Tennessee); Xiaotao Liu (Raleigh, North Carolina) |
| ASSIGNEE(S) | Florida State University Technology Transfer Office (Tallahassee, Florida) |
| INVENTOR(S) | Thomas Painter (Tallahassee, Florida); Ting Xu (Knoxville, Tennessee); Xiaotao Liu (Raleigh, North Carolina) |
| ABSTRACT | A method for making a composite superconductor and a superconductor made using the method. Superconducting filaments are embedded in a matrix material. Oxygen-containing elements are also embedded in the matrix material, with the oxygen-containing elements preferably being dispersed evenly among the superconducting filaments. A surrounding reinforcement material contains the other elements and preferably seals the superconductor from the surrounding atmosphere. |
| FILED | Tuesday, October 04, 2011 |
| APPL NO | 13/252749 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Superconductor technology: Apparatus, material, process 55/492 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637696 | Gellman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Samuel Helmer Gellman (Madison, Wisconsin); Yonggui Chi (Berkeley, California); Li Guo (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Samuel Helmer Gellman (Madison, Wisconsin); Yonggui Chi (Berkeley, California); Li Guo (Madison, Wisconsin) |
| ABSTRACT | The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide α-substituted-γ-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96-99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected γ2-amino acids, which are essential for systematic conformational studies of γ-peptide foldamers. |
| FILED | Monday, September 17, 2012 |
| APPL NO | 13/621553 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 227/02 (20130101) C07C 269/00 (20130101) C07C 271/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638106 | Gianchandani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yogesh B. Gianchandani (Ann Arbor, Michigan); Scott Andrew Wright (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Yogesh B. Gianchandani (Ann Arbor, Michigan); Scott Andrew Wright (Ann Arbor, Michigan) |
| ABSTRACT | A microdischarge-based pressure sensor that includes an anode, two cathodes, a drive circuit connected to the electrodes, and a measurement circuit that permits sensing of transient current pulses flowing through at least one of the electrodes. One of the cathodes is interposed between the anode and other cathode, and it includes a central opening which permits a microdischarge to occur between the anode and each cathode in response to applied voltage pulses from the drive circuit. Changes in relative current between the two cathodes are indicative of changes in ambient pressure in the microdischarge chamber. In other embodiments, a sealed chamber can be used with one of the electrodes acting as a diaphragm which deflects based on external pressure and changes its inter-electrode spacing, thereby altering the relative cathode currents. |
| FILED | Friday, May 28, 2010 |
| APPL NO | 12/789601 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/460 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638269 | Cortes-Medellin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | German Cortes-Medellin (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | German Cortes-Medellin (Ithaca, New York) |
| ABSTRACT | A non-planar, ultra-wide band, quasi-self-complementary feed antenna is disclosed. The antenna provides an invariant phase center location over its entire frequency band, is compact and includes a low profile, and includes input matching better than is currently available over a decade of frequency bandwidth. The very compact feed couples dual polarization electromagnetic energy to a transmitter from free space or air with minimum losses and mismatches over a very wide frequency band. |
| FILED | Thursday, June 05, 2008 |
| APPL NO | 12/663226 |
| ART UNIT | 2845 — Electrical Circuits and Systems |
| CURRENT CPC | Communications: Radio wave antennas 343/792.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638872 | Fazel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fatemeh Fazel (Boston, Massachusetts); Alfred Grau Besoli (Irvine, California); Hamid Jafakhani (Irvine, California); Franco De Flaviis (Irvine, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Fatemeh Fazel (Boston, Massachusetts); Alfred Grau Besoli (Irvine, California); Hamid Jafakhani (Irvine, California); Franco De Flaviis (Irvine, California) |
| ABSTRACT | Space-Time-State Block Coded MIMO communication system using reconfigurable antennas. One or more antennas are operates in accordance with a Space-Time-State Block Code (STS-BC) to effectuate channel coding of a signal being transmitted wirelessly between communication devices. In accordance with such an STS-BC, one or more antennas (being reconfigurable in nature) of a communication device are reconfigured in different radiation states. From some perspectives, this may be viewed as performing three-dimensional channel coding, in that, in addition to achieving at least time diversity of signals being transmitted (and also potentially including spatial diversity), state diversity may be achieved by adapting one or more characteristics of one or more antennas within the communication device. Such an STS-BC may operate in an open loop configuration without requiring any feedback from another communication device to which signals are transmitted. If desired, feedback may be employed for adaptively modifying an STS-BC (or selecting another STS-BC). |
| FILED | Friday, March 26, 2010 |
| APPL NO | 12/748366 |
| ART UNIT | 2631 — Digital Communications |
| CURRENT CPC | Pulse or digital communications 375/267 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639064 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zongfu Yu (Stanford, California); Shanhui Fan (Palo Alto, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Zongfu Yu (Stanford, California); Shanhui Fan (Palo Alto, California) |
| ABSTRACT | The refractive index of the at least one photonic structure having two separate photonic bands is modulated, so that light supplied to the at least one photonic structure and initially in one of the two photonic bands of the traveling along a forward direction in the at least one photonic structure is converted to light in a second one of the photonic bands, and light in the one photonic band traveling along a backward direction opposite to the forward direction in the at least one photonic structure is not converted and remains in the one photonic band, achieving non-reciprocity. |
| FILED | Wednesday, July 01, 2009 |
| APPL NO | 12/496474 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical waveguides 385/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639311 | Giszter |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Simon F. Giszter (Havertown, Pennsylvania) |
| ASSIGNEE(S) | Philadelphia Health and Education Corporation (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Simon F. Giszter (Havertown, Pennsylvania) |
| ABSTRACT | A single sensing probe comprising multiple, spatially separate, sensing sites is utilized to sense neural activity. The sensing probe includes multiple conductors each with multiple sensing sites in a fixed geometric arrangement. The sensing probe is configured to comprise multiple combined sensing sites in polytrode configuration. By appropriately combining the wire groupings at each combined sensing site, activity sensed from a single wire with multiple sensing sites, can be coupled with other wires to unmix signals from the spatially separate sites and leverage the power of combinatorics to maximize total recording bandwidth and single neuron/unit yield per wire and per probe. |
| FILED | Tuesday, December 14, 2010 |
| APPL NO | 12/967878 |
| ART UNIT | 3739 — Optics |
| CURRENT CPC | Surgery 6/377 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08639437 | Caminiti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lorenzo Caminiti (Ann Arbor, Michigan); Evan Quisenberry (Berkley, Michigan); Christopher Peplin (Pittsburgh, Pennsylvania); Domitilla Del Vecchio (Ann Arbor, Michigan); Rajeev Verma (Ann Arbor, Michigan) |
| ASSIGNEE(S) | Toyota Motor Engineering and Manufacturing North America, Inc. (Erlanger, Kentucky); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Lorenzo Caminiti (Ann Arbor, Michigan); Evan Quisenberry (Berkley, Michigan); Christopher Peplin (Pittsburgh, Pennsylvania); Domitilla Del Vecchio (Ann Arbor, Michigan); Rajeev Verma (Ann Arbor, Michigan) |
| ABSTRACT | The present invention discloses a back-propagating intersection collision avoidance (ICA) system for preventing two or more vehicles from colliding at an intersection. The ICA system can calculate predicted positions of the two or more vehicles in the near future, and both the current and future positions can be broadcast to surrounding vehicles using vehicle-to-vehicle communication. For each vehicle, a set of states, for example position, speed, acceleration, and the like, where a collision is imminent can be identified using state information for a local vehicle, a remote vehicle, and a known collision zone for the intersection. If the current states of the vehicles are determined to be in danger of entering the collision zone, the ICA system can control the vehicles to perform evasive driving maneuvers and/or alert the drivers. |
| FILED | Wednesday, June 09, 2010 |
| APPL NO | 12/796978 |
| ART UNIT | 3661 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Data processing: Vehicles, navigation, and relative location 71/301 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 08637002 | Dorner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Joe W. Dorner (Albany, Georgia); Bruce W. Horn (Albany, Georgia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Joe W. Dorner (Albany, Georgia); Bruce W. Horn (Albany, Georgia) |
| ABSTRACT | Non-toxigenic strains of Aspergillus are useful biocontrol agents for preventing toxin contamination in agricultural commodities, especially those for human consumption such as peanuts and corn, for example. |
| FILED | Wednesday, January 19, 2011 |
| APPL NO | 13/009430 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.500 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637049 | Pridgeon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yuping Wei Pridgeon (Auburn, Alabama); Phillip H. Klesius (Auburn, Alabama) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Yuping Wei Pridgeon (Auburn, Alabama); Phillip H. Klesius (Auburn, Alabama) |
| ABSTRACT | Safe and effective live vaccines against bacteria infecting aquatic animals were created through the induction of novobiocin-resistance in liquid culture and novobiocin- and rifampicin-resistance in liquid culture. |
| FILED | Wednesday, April 06, 2011 |
| APPL NO | 13/081134 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/244.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637237 | Henrich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vincent C. Henrich (Greensboro, North Carolina); Cary Alan Weinberger (Carrboro, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Greensboro (Greensboro, North Carolina) |
| INVENTOR(S) | Vincent C. Henrich (Greensboro, North Carolina); Cary Alan Weinberger (Carrboro, North Carolina) |
| ABSTRACT | Ecdysteroid action in Drosophila melanogaster and other insects is mediated by the dimerization of two nuclear receptors, the ecdysone receptor (EcR) and Ultraspiracle (USP), which regulate the transcription of target genes. Disclosed are nucleic acid constructs to identify insecticides having the ability to modify insect development and growth in a developmental stage-specific and/or species-specific manner. |
| FILED | Thursday, October 05, 2006 |
| APPL NO | 11/543682 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637304 | Burke |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dennis A. Burke (Olympia, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis A. Burke (Olympia, Washington) |
| ABSTRACT | An economical method for recovering nitrogen from liquid waste using autotrophic organisms and minimal energy inputs and without chemical additives. Solids are separated from anaerobically digested liquid waste. The resulting translucent liquid is introduced to a culture of autotrophic microorganisms in the presence of natural or artificial light, thereby accumulating biomass and producing a liquid effluent with elevated pH. The elevated-pH, liquid effluent is heated and stripped of ammonia, thereby producing a water vapor and stripped ammonia gas stream. The water vapor ammonia gas stream is condensed to form a liquid/ammonia condensate. The autotrophic microorganisms are advantageously cultivated in a photobioreactor comprising a plurality of axially spaced-apart, growth plates mounted for rotation to a shaft. The pH of the culture is adjustable within a preferred range of 8.0 to 10.5 by adjusting the light intensity and rotational speed. |
| FILED | Thursday, December 01, 2011 |
| APPL NO | 13/373860 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/290.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637325 | Basile et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Franco Basile (Fort Collins, Colorado); Shaofeng Zhang (Exton, Pennsylvania) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming) |
| INVENTOR(S) | Franco Basile (Fort Collins, Colorado); Shaofeng Zhang (Exton, Pennsylvania) |
| ABSTRACT | A method and apparatus for conducting the rapid pyrolysis of peptides, proteins, polymers, and biological materials. The method can be carried out at atmospheric pressures and takes only about 5 to 30 seconds. The samples are cleaved at the C-terminus of aspartic acid. The apparatus employs a probe on which the sample is heated and digested components analyzed. |
| FILED | Monday, February 16, 2009 |
| APPL NO | 12/371893 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/501 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637653 | Hammond et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John Hammond (Laurel, Maryland); Hyoun Sub Lim (Ellicott City, Maryland); Leslie L. Domier (Urbana, Illinois) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | John Hammond (Laurel, Maryland); Hyoun Sub Lim (Ellicott City, Maryland); Leslie L. Domier (Urbana, Illinois) |
| ABSTRACT | We have developed a versatile plant viral vector system based on Alternanthera mosaic virus (AltMV), suitable for infection by agroinfiltration or in vivo T7 transcripts from the same clone; agroinfection is enhanced by coinfiltration of a T7 RNA polymerase construct. Variants adapted for efficient protein expression, or for virus-induced gene silencing (VIGS), are based on a specific amino acid substitution (L88P) in the triple gene block 1 (TGB1) protein affecting RNA silencing suppression. A bipartite delivery system developed for AltMV delivers replicase (RdRp) functions separately from movement and encapsidation (TGB and coat protein, CP) functions by agroinfiltration, resulting in precise recombination of RdRp and TGB-CP constructs in planta. The bipartite delivery system has potential for high throughput protein expression or VIGS with the appropriate TGB1 variant, for hosts including Nicotiana benthamiana and Arabidopsis thaliana. Equivalent TGB1 substitutions in other potexviruses also reduced RNA silencing suppression, demonstrated with Potato virus X. |
| FILED | Tuesday, December 22, 2009 |
| APPL NO | 12/645027 |
| ART UNIT | 1638 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/23.720 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637689 | Bredsguard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jakob Bredsguard (Irvine, California); Jeremy Forest (Tustin, California); Travis Thompson (Anaheim, California) |
| ASSIGNEE(S) | Biosynthetic Technologies, LLC (Irvine, California) |
| INVENTOR(S) | Jakob Bredsguard (Irvine, California); Jeremy Forest (Tustin, California); Travis Thompson (Anaheim, California) |
| ABSTRACT | Provided herein are processes for preparing estolides and estolide base oils from fatty acid reactants utilizing catalysts. Further provided herein are processes for preparing carboxylic esters from at least one carboxylic acid reactant and at least one olefin. |
| FILED | Wednesday, August 31, 2011 |
| APPL NO | 13/199551 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Organic compounds 554/122 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637738 | Kidwell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kimberlee Kae Kidwell (Pullman, Washington); Camille Marie Steber (Pullman, Washington); Victor Louis Demacon (Pullman, Washington); Gary Bruce Shelton (Albion, Washington); Adrienne Bryan Burke (Pullman, Washington) |
| ASSIGNEE(S) | Washington State University (Pullman, Washington); The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Kimberlee Kae Kidwell (Pullman, Washington); Camille Marie Steber (Pullman, Washington); Victor Louis Demacon (Pullman, Washington); Gary Bruce Shelton (Albion, Washington); Adrienne Bryan Burke (Pullman, Washington) |
| ABSTRACT | The present invention provides methods for producing glyphosate-tolerant wheat genotypes by mutagenesis, glyphosate wheat plants produced by such methods, and related compositions and methods. |
| FILED | Thursday, August 07, 2008 |
| APPL NO | 12/672504 |
| ART UNIT | 1638 — Organic Chemistry |
| CURRENT CPC | Multicellular living organisms and unmodified parts thereof and related processes 8/300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 08635916 | Loverich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jacob Loverich (State Colleg, Pennsylvania); Stephen J. Wenner (Port Matilda, Pennsylvania); Jeremy E. Frank (Pine Grove Mills, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Loverich (State Colleg, Pennsylvania); Stephen J. Wenner (Port Matilda, Pennsylvania); Jeremy E. Frank (Pine Grove Mills, Pennsylvania) |
| ABSTRACT | An internal structural monitoring system for a structure that includes a sensor mounted within the structure to measure at least one of strain experienced by the structure and vibration experience by the structure. It includes a first system support mounted and second system support mounted in the structure, where the first system and the second system support are mounted in the structure such that the sensor is between the first system support and the second system support to hold the sensor in position so that the sensor senses at least one of strain and vibration. It includes a wireless communication unit mounted within the structure, the wireless communication unit connected to the sensor to receive data from the sensor and transmit the data to a receiver outside the structure. It includes a power supply mounted within the structure to supply necessary electrical power to the sensor and the communication unit. |
| FILED | Wednesday, July 06, 2011 |
| APPL NO | 13/176959 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/768 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637304 | Burke |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dennis A. Burke (Olympia, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis A. Burke (Olympia, Washington) |
| ABSTRACT | An economical method for recovering nitrogen from liquid waste using autotrophic organisms and minimal energy inputs and without chemical additives. Solids are separated from anaerobically digested liquid waste. The resulting translucent liquid is introduced to a culture of autotrophic microorganisms in the presence of natural or artificial light, thereby accumulating biomass and producing a liquid effluent with elevated pH. The elevated-pH, liquid effluent is heated and stripped of ammonia, thereby producing a water vapor and stripped ammonia gas stream. The water vapor ammonia gas stream is condensed to form a liquid/ammonia condensate. The autotrophic microorganisms are advantageously cultivated in a photobioreactor comprising a plurality of axially spaced-apart, growth plates mounted for rotation to a shaft. The pH of the culture is adjustable within a preferred range of 8.0 to 10.5 by adjusting the light intensity and rotational speed. |
| FILED | Thursday, December 01, 2011 |
| APPL NO | 13/373860 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/290.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638963 | Parkins |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John W. Parkins (Ithaca, New York) |
| ASSIGNEE(S) | Red Tail Hawk Corporation (Ithaca, New York) |
| INVENTOR(S) | John W. Parkins (Ithaca, New York) |
| ABSTRACT | A hearing protection system with talk-through having a pair of rigid earcups enclosing a microphone, amplifier and speaker. A concha simulator, having a volume simulating that of the concha of a human ear, is acoustically coupled to the microphone, and also to the outside through an opening in the earcup. By coupling the microphone to the concha simulator, instead of directly to the outside, the acoustic response of the talk-through more accurately represents the hearing of a user. |
| FILED | Friday, May 28, 2010 |
| APPL NO | 12/789942 |
| ART UNIT | 2832 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Electrical audio signal processing systems and devices 381/322 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 08637082 | Tulsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eric Tulsky (Berkeley, California); Joseph Bartel (Eugene, Oregon); Joseph Treadway (Eugene, Oregon) |
| ASSIGNEE(S) | Life Technologies Corporation (Carlsbad, California) |
| INVENTOR(S) | Eric Tulsky (Berkeley, California); Joseph Bartel (Eugene, Oregon); Joseph Treadway (Eugene, Oregon) |
| ABSTRACT | Nanocrystals having a ZnTe core and methods for making and using them to construct core-shell nanocrystals are described. These core-shell nanocrystals are highly stable and provide quantum yields and stability suitable for applications such as flow cytometry, cellular imaging, and protein blotting, medical imaging, and other applications where cadmium toxicity is an issue. |
| FILED | Friday, October 02, 2009 |
| APPL NO | 13/119170 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/489 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08638998 | Steines et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Daniel Steines (Lexington, Massachusetts); Bijan Timsari (San Diego, California); Konstantinos Tsougarakis (San Francisco, California); Philipp Lang (Lexington, Massachusetts) |
| ASSIGNEE(S) | ConforMIS, Inc. (Bedford, Massachusetts) |
| INVENTOR(S) | Daniel Steines (Lexington, Massachusetts); Bijan Timsari (San Diego, California); Konstantinos Tsougarakis (San Francisco, California); Philipp Lang (Lexington, Massachusetts) |
| ABSTRACT | In accordance with the present invention there is provided methods for generating an isotropic or near-isotropic three-dimensional images from two-dimensional images. In accordance with the present invention the method includes, obtaining a first image of a body part in a first plane, wherein the first image generates a first image data volume; obtaining a second image of the body part in a second plane, wherein the second image generates a second image data volume; and combining the first and second image data volumes to form a resultant image data volume, wherein the resultant image data volume is isotropic or near-isotropic. |
| FILED | Monday, January 09, 2012 |
| APPL NO | 13/345843 |
| ART UNIT | 2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Image analysis 382/128 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 08640147 | Park et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yoonho Park (Hawthorne, New York); Philippe L. Selo (Hawthorne, New York); Chitra Venkatramani (Hawthorne, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Yoonho Park (Hawthorne, New York); Philippe L. Selo (Hawthorne, New York); Chitra Venkatramani (Hawthorne, New York) |
| ABSTRACT | A method, system and computer program product of setting up a virtual connection at run time. The method includes the steps of: analyzing a topology of an application to determine at least one port pair where the port pair comprises an output port of a first operator and an input port of a second operator; configuring a first auxiliary operator to receive data from a first operator; configuring a second auxiliary operator to send data to a second operator; deploying the first operator, the second operator, the first auxiliary operator and the second auxiliary operator; receiving a function address of the second auxiliary operator; and sending the function address of the second auxiliary operator to a first destination; where at least one of the steps is carried out using a computer device so that the virtual connection is setup at run time. |
| FILED | Thursday, November 11, 2010 |
| APPL NO | 12/944246 |
| ART UNIT | 2194 — Interprocess Communication and Software Development |
| CURRENT CPC | Electrical computers and digital processing systems: Interprogram communication or interprocess communication 719/320 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08640189 | Ernst et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Richard J. Ernst (Rowlett, Texas); James H. Swedberg (Richardson, Texas); Matthew J. Hicks (Dallas, Texas); Herbert T. Riggs, III (Grasonville, Maryland); Matt A. Powers (Farmers Branch, Texas); Jason E. Ostermann (Plano, Texas) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Richard J. Ernst (Rowlett, Texas); James H. Swedberg (Richardson, Texas); Matthew J. Hicks (Dallas, Texas); Herbert T. Riggs, III (Grasonville, Maryland); Matt A. Powers (Farmers Branch, Texas); Jason E. Ostermann (Plano, Texas) |
| ABSTRACT | In certain embodiments, a method includes receiving from a validation system a request to apply a first policy service to a message. The validation system determines whether the message may be transmitted to a second network by validating a plurality of tokens associated with the message. The method includes receiving at least one result from a policy service engine of applying the first policy service to the message and determining at least one predefined assertion based on the received at least one result. The message includes generating a first token by encrypting the at least one predefined assertion using a first parameter associated with the first service node and not the second service node. The method includes sending the message and the first token to the validation system. |
| FILED | Monday, March 07, 2011 |
| APPL NO | 13/042367 |
| ART UNIT | 2433 — Cryptography and Security |
| CURRENT CPC | Information security 726/1 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 08637654 | Ballantyne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John Ballantyne (Orlando, Florida); Jane Juusola (Glen Allen, Virginia) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | John Ballantyne (Orlando, Florida); Jane Juusola (Glen Allen, Virginia) |
| ABSTRACT | This invention relates to a ribonucleic acid (RNA) based assay system for body fluid identification, and in particular to a novel, multiplex, parallel assay system based on messenger RNA expressed in human tissue, and to a method for using the same. |
| FILED | Tuesday, September 01, 2009 |
| APPL NO | 12/584140 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Organic compounds 536/24.300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 08636407 | Woodard |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marie Woodard (Hampton, Virginia) |
| ASSIGNEE(S) | United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Marie Woodard (Hampton, Virginia) |
| ABSTRACT | A wireless temperature sensor includes an electrical conductor and a dielectric material on the conductor. The conductor is electrically unconnected and is shaped for storage of an electric field and a magnetic field. In the presence of a time-varying magnetic field, the conductor resonates to generate harmonic electric and magnetic field responses, each of which has a frequency associated therewith. The material is selected such that it experiences changes in either dielectric or magnetic permeability attributes in the presence of a temperature change. Shifts from the sensor's baseline frequency response indicate that the material has experienced a temperature change. |
| FILED | Thursday, February 17, 2011 |
| APPL NO | 13/029426 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Thermal measuring and testing 374/120 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Geospatial Intelligence Agency (NGA)
| US 08639502 | Boucheron et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Laura E. Boucheron (Las Cruces, New Mexico); Phillip L. De Leon (Las Cruces, New Mexico) |
| ASSIGNEE(S) | Arrowhead Center, Inc. (Las Cruces, New Mexico) |
| INVENTOR(S) | Laura E. Boucheron (Las Cruces, New Mexico); Phillip L. De Leon (Las Cruces, New Mexico) |
| ABSTRACT | A speech enhancement method (and concomitant computer-readable medium comprising computer software encoded thereon) comprising receiving samples of a user's speech, determining mel-frequency cepstral coefficients of the samples, constructing a Gaussian mixture model of the coefficients, receiving speech from a noisy environment, determining mel-frequency cepstral coefficients of the noisy speech, estimating mel-frequency cepstral coefficients of clean speech from the mel-frequency cepstral coefficients of the noisy speech and from the Gaussian mixture model, and outputting a time-domain waveform of enhanced speech computed from the estimated mel-frequency cepstral coefficients. |
| FILED | Tuesday, February 16, 2010 |
| APPL NO | 12/706482 |
| ART UNIT | 2657 — Linguistics, Speech Processing and Audio Compression |
| CURRENT CPC | Data processing: Speech signal processing, linguistics, language translation, and audio compression/decompression 74/226 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 08637011 | Baron et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jody L. Baron (Mill Valley, California); Lewis L. Lanier (Los Altos, California) |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Jody L. Baron (Mill Valley, California); Lewis L. Lanier (Los Altos, California) |
| ABSTRACT | The present invention relates to methods and compositions for treating and/or preventing inflammation associated with viral infection and solid organ transplant rejection. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D. |
| FILED | Friday, May 04, 2007 |
| APPL NO | 12/299608 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/130.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08637759 | Foster et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas E. Foster (Covington, Washington); James Snyder (Mountain View, California) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Thomas E. Foster (Covington, Washington); James Snyder (Mountain View, California) |
| ABSTRACT | A solar cell and method for producing same is disclosed. The solar cell includes a multijunction solar cell structure and a notch filter designed to reflect solar energy that does not contribute to the current output of the multijunction solar cell. By reflecting unused solar energy, the notch filter allows the solar cell to run cooler (and thus more efficiently) yet it still allows all junctions to fully realize their electrical current production capability. |
| FILED | Friday, December 16, 2005 |
| APPL NO | 11/305434 |
| ART UNIT | 1759 — Organic Chemistry |
| CURRENT CPC | Batteries: Thermoelectric and photoelectric 136/243 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US PP24198 | Finn |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chad Finn (Corvallis, Oregon) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Chad Finn (Corvallis, Oregon) |
| ABSTRACT | Description and specifications of a new and distinct red raspberry cultivar which originated from seed produced from open pollinated flowers of ‘Isabel’ (U.S. Plant Pat. No. 9,340) is provided. This new primocane fruiting cultivar can be distinguished by its high yields of large, very bright-red-colored, sweet, flavorful fruit with excellent fresh fruit quality borne on primocanes in late summer. |
| FILED | Friday, September 02, 2011 |
| APPL NO | 13/199578 |
| ART UNIT | 1661 — Plants |
| CURRENT CPC | Plants PLT/204 |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, January 28, 2014.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2014/fedinvent-patents-20140128.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page