FedInvent™ Patents
Patent Details for Tuesday, September 30, 2014
This page was updated on Monday, March 27, 2023 at 04:05 AM GMT
Department of Health and Human Services (HHS)
| US 08844369 | Botvinick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Elliot Botvinick (Irvine, California); Samir Shreim (Irvine, California); Maxwell Kotlarchyk (Costa Mesa, California) |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Elliot Botvinick (Irvine, California); Samir Shreim (Irvine, California); Maxwell Kotlarchyk (Costa Mesa, California) |
| ABSTRACT | An apparatus and method for providing a gradient strain to an extracellular matrix to induce mechanotransduction. The gradient strain can be produced by adhering the extracellular matrix to a post and the walls of a sample holder, and then rotating the post and the sample holder. This strain can result in increased stiffness of the extracellular matrix with very little loss of pore size. |
| FILED | Thursday, April 26, 2012 |
| APPL NO | 13/457342 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3691 (20130101) Apparatus for Enzymology or Microbiology; C12M 35/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/24 (20130101) Original (OR) Class G01N 11/14 (20130101) G01N 2203/0089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845494 | Whitall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jill Whitall (Annapolis, Maryland); Sandra A. McCombe-Waller (Ellicott City, Maryland); Muniswamappa Anjanappa (Ellicott City, Maryland) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland); University of Maryland, Baltimore County (Baltimore, Maryland) |
| INVENTOR(S) | Jill Whitall (Annapolis, Maryland); Sandra A. McCombe-Waller (Ellicott City, Maryland); Muniswamappa Anjanappa (Ellicott City, Maryland) |
| ABSTRACT | A person's step length and rate may be measured, for example, through sensors that collect spatial and temporal gait parameter data. The measurements are then used to determine the rate of a rhythmic auditory cue to improve the person's gait. For example, a system links sensors to detect step rate and length to an audio cue provided to headphones, while providing the appropriate algorithms to accomplish real time adjustments to the audio cues as needed to better help change the person's step length vs. step rate ratio in a desired direction depending on therapeutic or performance goals. |
| FILED | Tuesday, September 29, 2009 |
| APPL NO | 13/121701 |
| ART UNIT | 3764 — Optics |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 3/00 (20130101) Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 24/0003 (20130101) A63B 69/0028 (20130101) A63B 69/0035 (20130101) A63B 71/0686 (20130101) Original (OR) Class A63B 2024/0068 (20130101) A63B 2071/063 (20130101) A63B 2071/0652 (20130101) A63B 2220/20 (20130101) A63B 2220/22 (20130101) A63B 2220/40 (20130101) A63B 2220/44 (20130101) A63B 2220/802 (20130101) A63B 2225/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845523 | Lawrence et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dale A. Lawrence (Louisville, Colorado); Sutha Aphanuphong (Boulder, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Dale A. Lawrence (Louisville, Colorado); Sutha Aphanuphong (Boulder, Colorado) |
| ABSTRACT | There is disclosed a MicroFlex Scope (MFS). The MFS is a dexterous endoscope providing access, direct visualization, tissue sampling, and treatment, of body lumens. In one embodiment, the distal end of the MFS is an ultra-flexible tip that comprises a plurality of thin, curved shape memory alloy (SMA) actuator elements attached to at least one structural skeleton, a coil spring skeleton or hinge structure. The SMA actuator elements in each structural skeleton segment are indirectly heated by a heater element and produce force in response to their temperature relative to specific thresholds. In configurations comprising a plurality of actuator elements, multiplexing/demultiplexing of heating currents and sensor voltages may be accomplished via a parallel bus and demultiplexing circuit. In this regard, a demultiplexing circuit using standard microelectronic fabrication techniques may be designed to achieve individual sensing and control over each actuator element. |
| FILED | Friday, December 23, 2011 |
| APPL NO | 13/336726 |
| ART UNIT | 3779 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/012 (20130101) A61B 1/2676 (20130101) Original (OR) Class A61B 2017/003 (20130101) A61B 2017/00398 (20130101) A61B 2017/00867 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845555 | Shih et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wan Y. Shih (Bryn Mawr, Pennsylvania); Wei-Heng Shih (Bryn Mawr, Pennsylvania); Hakki Yegingil (Philadelphia, Pennsylvania); Ari D. Brooks (Cherry Hill, New Jersey) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania); Philadelphia Health and Education Corporation (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Wan Y. Shih (Bryn Mawr, Pennsylvania); Wei-Heng Shih (Bryn Mawr, Pennsylvania); Hakki Yegingil (Philadelphia, Pennsylvania); Ari D. Brooks (Cherry Hill, New Jersey) |
| ABSTRACT | The present invention provides a sensor system for measuring an elastic modulus and a shear modulus and a method for using the sensor system to evaluate a tissue by determining the presence of and/or characterizing abnormal growths. The method involves applying a set of forces of different magnitudes to one or more locations of tissue, detecting the corresponding displacements due to said applied forces, determining the forces acting on those locations of tissue which are a combination of forces from the applied voltages and the countering forces from tissue deformation, obtaining the elastic modulus and/or shear modulus for a plurality of locations, and determining abnormal growth invasiveness, malignancy or the presence of a tumor from said elastic and/or shear moduli. |
| FILED | Thursday, September 19, 2013 |
| APPL NO | 14/031307 |
| ART UNIT | 3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0053 (20130101) A61B 5/442 (20130101) A61B 5/4312 (20130101) A61B 8/085 (20130101) Original (OR) Class A61B 8/403 (20130101) A61B 8/485 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/0672 (20130101) G01N 2291/02475 (20130101) G01N 2291/02827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845557 | Giuffrida et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Great Lakes NeuroTechnologies Inc. (Valley View, Ohio) |
| ASSIGNEE(S) | Great Lakes NeuroTechnologies Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Joseph P. Giuffrida (Hinckley, Ohio); Dustin A. Heldman (Shaker Heights, Ohio) |
| ABSTRACT | The present invention relates to a movement disorder monitor with high sensitivity, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a drug delivery system for dosing a subject in response to the increased severity of a subject's symptoms. The present invention provides for a system and method, which can accurately and repeatably quantify symptoms of movements disorders, accurately quantifies symptoms utilizing both kinetic information and/or electromyography (EMG) data, that can be worn continuously to provide continuous information to be analyzed as needed by the clinician, that can provide analysis in real-time, that allows for home monitoring of symptoms in subject's with these movement disorders to capture the complex fluctuation patterns of the disease over the course of days, weeks or months, that maximizes subject safety, and that provides substantially real-time remote access to data by the clinician or physician. |
| FILED | Tuesday, March 05, 2013 |
| APPL NO | 13/784939 |
| ART UNIT | 3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Surgery 6/595 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845755 | Dillingham |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | iFIT Prosthetics, LLC (Pewaukee, Wisconsin) |
| ASSIGNEE(S) | iFit Prosthetics, LLC (Pewaukee, Wisconsin) |
| INVENTOR(S) | Timothy R. Dillingham (Merion Station, Pennsylvania) |
| ABSTRACT | An adjustable prosthesis system for a residual limb includes: an adjustable outer shell having an adjustable inner volume and an adjustable inner shape; at least one closure component attached to the adjustable outer shell and adapted to adjust at least one of the adjustable inner volume and the adjustable inner shape of the adjustable outer shell; an inner liner adapted to receive the residual limb and to be inserted in the adjustable inner volume of the adjustable outer shell; and an adjustable connector having a proximal end adjustably connected to a distal end of the adjustable outer shell and adapted to provide concurrently for a plurality of directional adjustments and/or angular adjustments of a position of the distal end of the adjustable outer shell relative to the proximal end of the adjustable connector, a distal end of the adjustable connector being adapted to connect to a prosthetic device. |
| FILED | Thursday, October 10, 2013 |
| APPL NO | 14/050739 |
| ART UNIT | 3738 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/54 (20130101) A61F 2/60 (20130101) A61F 2/64 (20130101) Original (OR) Class A61F 2/76 (20130101) A61F 2/78 (20130101) A61F 2/80 (20130101) A61F 2/601 (20130101) A61F 2/7812 (20130101) A61F 2002/502 (20130101) A61F 2002/546 (20130101) A61F 2002/608 (20130101) A61F 2002/785 (20130101) A61F 2002/5018 (20130101) A61F 2002/5023 (20130101) A61F 2002/5026 (20130101) A61F 2002/5027 (20130101) A61F 2002/7862 (20130101) A61F 2002/7875 (20130101) A61F 2002/7881 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 11/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845999 | Wright et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ernest M. Wright (Los Angeles, California); Jorge R. Barrio (Agoura Hills, California); Bruce A. Hirayama (Los Angeles, California); Vladimir Kepe (Los Angeles, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ernest M. Wright (Los Angeles, California); Jorge R. Barrio (Agoura Hills, California); Bruce A. Hirayama (Los Angeles, California); Vladimir Kepe (Los Angeles, California) |
| ABSTRACT | Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with 18F, 123I, or 124I, or free hexoses radiolabeled with 18F, 123I, or 124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions. |
| FILED | Tuesday, May 23, 2006 |
| APPL NO | 11/920904 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) Original (OR) Class G01N 33/6872 (20130101) G01N 2400/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846002 | Byrd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Ohio State University (Columbus, Ohio); Immunomedics, Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | The Ohio State University (Columbus, Ohio); Immunomedics, Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | John C. Byrd (Columbus, Ohio); David M. Goldenberg (Mendham, New Jersey); Hans J. Hansen (Picayune, Mississippi) |
| ABSTRACT | Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions. |
| FILED | Thursday, January 03, 2013 |
| APPL NO | 13/733445 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/395 (20130101) A61K 39/395 (20130101) A61K 47/488 (20130101) A61K 47/48823 (20130101) Original (OR) Class A61K 51/1234 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) Peptides C07K 16/2803 (20130101) C07K 16/2833 (20130101) C07K 16/2896 (20130101) C07K 2317/24 (20130101) C07K 2317/73 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 2333/70596 (20130101) G01N 2800/245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846003 | Panitch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alyssa Panitch (West Lafayette, Indiana); John E. Paderi (Lafayette, Indiana); Kinam Park (West Lafayette, Indiana); Katherine Stuart (Lafayette, Indiana); Steve Higbee (Lafayette, Indiana) |
| ASSIGNEE(S) | Symic Biomedical, Inc. (San Francisco, California) |
| INVENTOR(S) | Alyssa Panitch (West Lafayette, Indiana); John E. Paderi (Lafayette, Indiana); Kinam Park (West Lafayette, Indiana); Katherine Stuart (Lafayette, Indiana); Steve Higbee (Lafayette, Indiana) |
| ABSTRACT | This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use. |
| FILED | Friday, March 27, 2009 |
| APPL NO | 12/934551 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) A61L 27/54 (20130101) A61L 27/3804 (20130101) A61L 2300/25 (20130101) A61L 2300/42 (20130101) Peptides C07K 14/78 (20130101) Original (OR) Class C07K 14/4725 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846030 | Engelhardt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John F. Engelhardt (Iowa City, Iowa); Dongsheng Duan (Columbia, Missouri) |
| ASSIGNEE(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | John F. Engelhardt (Iowa City, Iowa); Dongsheng Duan (Columbia, Missouri) |
| ABSTRACT | Agents and methods to alter rAAV transduction are provided. |
| FILED | Tuesday, December 13, 2005 |
| APPL NO | 11/301601 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.600 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846031 | Roy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Soumitra Roy (Liederdorp, Netherlands); James M. Wilson (Glen Mills, Pennsylvania); Luc H. Vandenberghe (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Soumitra Roy (Liederdorp, Netherlands); James M. Wilson (Glen Mills, Pennsylvania); Luc H. Vandenberghe (Philadelphia, Pennsylvania) |
| ABSTRACT | Novel simian adenovirus 41 and two isolates thereof are described. Various uses of these isolates, including construction of a recombinant vector which comprises simian adenovirus 41 sequences and a heterologous gene under the control of regulatory sequences are provided. A cell line which expresses simian adenovirus 41 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. |
| FILED | Thursday, May 27, 2010 |
| APPL NO | 13/321985 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/93.600 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846051 | Kew et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Olen M. Kew (Alpharetta, Georgia); Cara C. Burns (Avondale Estates, Georgia); Jing Shaw (Decatur, Georgia); Raymond Campagnoli (Decatur, Georgia); Jacqueline Quay (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention (Washington, District of Columbia) |
| INVENTOR(S) | Olen M. Kew (Alpharetta, Georgia); Cara C. Burns (Avondale Estates, Georgia); Jing Shaw (Decatur, Georgia); Raymond Campagnoli (Decatur, Georgia); Jacqueline Quay (Chapel Hill, North Carolina) |
| ABSTRACT | Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed. |
| FILED | Friday, October 07, 2005 |
| APPL NO | 11/576941 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 2039/522 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/245 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/67 (20130101) C12N 2710/16162 (20130101) C12N 2710/16662 (20130101) C12N 2710/16762 (20130101) C12N 2760/16162 (20130101) C12N 2760/18462 (20130101) C12N 2760/18562 (20130101) C12N 2770/20062 (20130101) C12N 2770/24162 (20130101) C12N 2770/32162 (20130101) C12N 2770/32762 (20130101) C12N 2770/36262 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846056 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Larry J. Anderson (Atlanta, Georgia); Lia M. Haynes (Lithonia, Georgia); Ralph A. Tripp (Decatur, Georgia) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control (Washington, District of Columbia) |
| INVENTOR(S) | Larry J. Anderson (Atlanta, Georgia); Lia M. Haynes (Lithonia, Georgia); Ralph A. Tripp (Decatur, Georgia) |
| ABSTRACT | Immunogenic polypeptides corresponding to one or more RSV G glycoproteins, or analogues thereof, are provided as components of vaccines. The inventive compositions are useful as both a prophylactic and therapeutic for the prevention and treatment of RSV infections and associated pulmonary or other diseases. The inventive immunogens include regions of the RSV G protein, specifically, amino acid residues 164-176 of RSV G A2 protein or analogues thereof. This inventive immunogen is operable alone or in combination with other polypeptides such as the RSV G protein amino acid residues 155-206, or other vaccines such as live RSV vaccines, or inactivated RSV vaccines or immunogenic analogues thereof. |
| FILED | Wednesday, August 04, 2010 |
| APPL NO | 13/388839 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) A61K 2039/545 (20130101) A61K 2039/555 (20130101) Peptides C07K 14/005 (20130101) C07K 14/135 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18522 (20130101) C12N 2760/18534 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846058 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael J. Smith (Silver Spring, Maryland); Alison D. O'Brien (Bethesda, Maryland); Louise D. Teel (Silver Spring, Maryland); Angela R. Melton-Celsa (Sterling, Virginia) |
| ASSIGNEE(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Michael J. Smith (Silver Spring, Maryland); Alison D. O'Brien (Bethesda, Maryland); Louise D. Teel (Silver Spring, Maryland); Angela R. Melton-Celsa (Sterling, Virginia) |
| ABSTRACT | A chimeric Shiga toxoid according to the invention contains an enzymatically-inactivated StxA subunit and a native StxB subunit. This hybrid Shiga toxoid induces the production of broadly cross-reactive species of antibodies against Shiga toxin following immunization. The StxA subunit is modified so that it is enzymatically inactive. The invention thus encompasses the Shiga toxoid or fragments thereof and the nucleic acid sequence of the Shiga toxoid or fragments thereof. The invention further encompasses the production of a Shiga toxoid, the production of antibodies using the Shiga toxoid and methods of productions, and an immunogenic composition containing the Shiga toxoid. |
| FILED | Friday, February 16, 2007 |
| APPL NO | 12/279423 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/0258 (20130101) A61K 2039/55566 (20130101) Peptides C07K 14/245 (20130101) C07K 2319/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846081 | Reshetnyak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yana K. Reshetnyak (South Kingstown, Rhode Island); Oleg A. Andreev (South Kingstown, Rhode Island); Donald M. Engelman (New Haven, Connecticut) |
| ASSIGNEE(S) | Rhode Island Board of Governors for Higher Education (Kingston, Rhode Island); Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Yana K. Reshetnyak (South Kingstown, Rhode Island); Oleg A. Andreev (South Kingstown, Rhode Island); Donald M. Engelman (New Haven, Connecticut) |
| ABSTRACT | The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide. |
| FILED | Friday, August 12, 2011 |
| APPL NO | 13/208902 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/450 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846096 | Destache |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christopher J. Destache (Omaha, Nebraska) |
| ASSIGNEE(S) | Creighton University (Omaha, Nebraska) |
| INVENTOR(S) | Christopher J. Destache (Omaha, Nebraska) |
| ABSTRACT | Provided herein are nanoparticles and methods for using nanoparticles. The nanoparticles include at least three antiretroviral agents. When introduced to cells the nanoparticles cause an increase in the intracellular concentration of the antiretroviral agents to a level that is at least the IC50 against HIV-I or HIV-2. This concentration may be maintained for at least 21 days after the cells are contacted with the nanoparticle. When administered to a subject the nanoparticles cause the concentration of the antiretroviral agents to increase to at least 100 ng/ml in the serum of the subject, at least 0.5 μg/gram tissue in an organ of the subject, or a combination thereof. Such a concentration may be maintained for at least 21 days after the administration. |
| FILED | Friday, December 11, 2009 |
| APPL NO | 13/132442 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/0019 (20130101) A61K 9/5153 (20130101) A61K 31/427 (20130101) Original (OR) Class A61K 31/427 (20130101) A61K 31/513 (20130101) A61K 31/513 (20130101) A61K 31/536 (20130101) A61K 31/536 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846183 | Unger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marc A. Unger (San Mateo, California); Hou-Pu Chou (Sunnyvale, California); Todd A. Thorsen (Pasadena, California); Axel Scherer (Laguna Beach, California); Stephen R. Quake (Stanford, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Marc A. Unger (San Mateo, California); Hou-Pu Chou (Sunnyvale, California); Todd A. Thorsen (Pasadena, California); Axel Scherer (Laguna Beach, California); Stephen R. Quake (Stanford, California) |
| ABSTRACT | A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate. |
| FILED | Thursday, October 20, 2011 |
| APPL NO | 13/278061 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2219/005 (20130101) B01J 2219/00355 (20130101) B01J 2219/00378 (20130101) B01J 2219/00396 (20130101) B01J 2219/00398 (20130101) B01J 2219/00439 (20130101) B01J 2219/00527 (20130101) B01J 2219/00605 (20130101) B01J 2219/00612 (20130101) B01J 2219/00659 (20130101) B01J 2219/00707 (20130101) B01J 2219/00722 (20130101) B01J 2219/00725 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502707 (20130101) B01L 3/502738 (20130101) B01L 7/54 (20130101) B01L 9/527 (20130101) B01L 2200/10 (20130101) B01L 2200/025 (20130101) B01L 2200/027 (20130101) B01L 2200/0605 (20130101) B01L 2300/14 (20130101) B01L 2300/18 (20130101) B01L 2300/123 (20130101) B01L 2300/0681 (20130101) B01L 2300/0861 (20130101) B01L 2300/0887 (20130101) B01L 2400/046 (20130101) B01L 2400/0481 (20130101) B01L 2400/0655 (20130101) B01L 2400/0688 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 2037/1081 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 2201/036 (20130101) B81B 2201/054 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00119 (20130101) B81C 2201/019 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 2535/125 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/043 (20130101) Fluid-circuit Elements Predominantly Used for Computing or Control Purposes F15C 5/00 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0001 (20130101) F16K 99/0015 (20130101) F16K 99/0046 (20130101) F16K 99/0051 (20130101) F16K 99/0059 (20130101) F16K 2099/008 (20130101) F16K 2099/0074 (20130101) F16K 2099/0076 (20130101) F16K 2099/0078 (20130101) F16K 2099/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846307 | Neumann |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas Neumann (Seattle, Washington) |
| ASSIGNEE(S) | Nortis, Inc. (Gig Harbor, Washington) |
| INVENTOR(S) | Thomas Neumann (Seattle, Washington) |
| ABSTRACT | Creating a tissue structure in vitro includes juxtaposing mandrels on a culture/perfusion device frame where the mandrels are spaced apart substantially parallel to each other and connecting the mandrels to tubes including an upstream tubes and downstream tubes. The upstream tubes are connected with an upstream manifold and the downstream tubes are connected to a downstream manifold. The frame and the mandrels are sterilized, coated and seeded with cells that multiply and form circular layers around each of the mandrels until the circular layers merge into a tissue structure which is subjected to a growth medium. The mandrels are extracted and the tissue structure is perfused. |
| FILED | Friday, August 14, 2009 |
| APPL NO | 12/541707 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/06 (20130101) C12M 23/20 (20130101) C12M 29/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0691 (20130101) Original (OR) Class C12N 2533/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846321 | Sacks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Frank M. Sacks (Belmont, Massachusetts); Jeremy D. Furtado (Berkley, Massachusetts); Eric Rimm (Brookline, Massachusetts); Majken Jensen (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Frank M. Sacks (Belmont, Massachusetts); Jeremy D. Furtado (Berkley, Massachusetts); Eric Rimm (Brookline, Massachusetts); Majken Jensen (Cambridge, Massachusetts) |
| ABSTRACT | Presented herein are methods of diagnosing, assessing, and treating an individual at increased risk if developing coronary heart disease or cardiovascular event, based on the individual's level of high density lipoprotein cholesterol apoCIII (HDL-C apoCIII). |
| FILED | Friday, March 11, 2011 |
| APPL NO | 13/046682 |
| ART UNIT | 1678 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/324 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846331 | McNaughton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brandon H. McNaughton (Ann Arbor, Michigan); Paivo Kinnunen (Ann Arbor, Michigan); Raoul Kopelman (Ann Arbor, Michigan); Alan Hunt (Plymouth, Michigan); Roy Clarke (Ann Arbor, Michigan); Irene Sinn (Ann Arbor, Michigan); Remy Elbez (Ann Arbor, Michigan); Theodore Albertson (Bloomfield, Michigan) |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Brandon H. McNaughton (Ann Arbor, Michigan); Paivo Kinnunen (Ann Arbor, Michigan); Raoul Kopelman (Ann Arbor, Michigan); Alan Hunt (Plymouth, Michigan); Roy Clarke (Ann Arbor, Michigan); Irene Sinn (Ann Arbor, Michigan); Remy Elbez (Ann Arbor, Michigan); Theodore Albertson (Bloomfield, Michigan) |
| ABSTRACT | Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is descried. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also described herein are methods for controlling the illumination and imaging of rotating magnetic particles. |
| FILED | Monday, August 29, 2011 |
| APPL NO | 13/220381 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/29 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846341 | Kaminski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Naftali Kaminski (Pittsburgh, Pennsylvania); Kevin F. Gibson (Gibsonia, Pennsylvania); Bernadette R. Gochuico (Potomac, Maryland); Thomas J. Richards (Pittsburgh, Pennsylvania); Ivan Rosas (Boston, Massachusetts); Kazuhisa Konishi (Kyoto, Japan); Moises Selman (Mexico City, Mexico); Jose David Herazo-Maya (Pittsburgh, Pennsylvania); Imre Noth (Chicago, Illinois) |
| ASSIGNEE(S) | University of Pittsburgh of the Commonwealth System of Higher Education (Pittsburg, Pennsylvania); The University of Chicago (Chicago, Illinois); Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas D.F. (Mexico City, Mexico) |
| INVENTOR(S) | Naftali Kaminski (Pittsburgh, Pennsylvania); Kevin F. Gibson (Gibsonia, Pennsylvania); Bernadette R. Gochuico (Potomac, Maryland); Thomas J. Richards (Pittsburgh, Pennsylvania); Ivan Rosas (Boston, Massachusetts); Kazuhisa Konishi (Kyoto, Japan); Moises Selman (Mexico City, Mexico); Jose David Herazo-Maya (Pittsburgh, Pennsylvania); Imre Noth (Chicago, Illinois) |
| ABSTRACT | The present invention relates to the discovery that of a panel of serum or plasma markers may be used to diagnose Idiopathic Pulmonary Fibrosis (“IPF”) and distinguish this condition from other lung ailments. It further relates to the identification of markers associated with IPF disease progression. |
| FILED | Thursday, March 03, 2011 |
| APPL NO | 13/039989 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/69.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846350 | Spivack et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Simon D. Spivack (Sleepy Hollow, New York); Miao Shi (Woodside, New York); Weiguo Han (Albany, New York) |
| ASSIGNEE(S) | Albert Einstein College of Medicine of Yeshiva University (Bronx, New York) |
| INVENTOR(S) | Simon D. Spivack (Sleepy Hollow, New York); Miao Shi (Woodside, New York); Weiguo Han (Albany, New York) |
| ABSTRACT | The present invention provides methods and kits for determining which microRNAs bind to a target mRNA where the methods comprise the steps of (a) creating a bait sequence from the target mRNA, where the bait sequence comprises a label that binds to a binding agent; (b) adding a mixture of microRNAs to the bait sequence; (c) separating the microRNAs that bind to the bait sequence from those microRNAs that do not bind; and (d) identifying the microRNAs that bind to the bait sequence, wherein the microRNAs identified are those that bind to the target mRNA. |
| FILED | Monday, October 18, 2010 |
| APPL NO | 13/500083 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2320/11 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) C12Q 1/6858 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846360 | Harper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeffrey Wade Harper (Wellesley, Massachusetts); Jianping Jin (Pearland, Texas) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Jeffrey Wade Harper (Wellesley, Massachusetts); Jianping Jin (Pearland, Texas) |
| ABSTRACT | A novel activating enzyme for ubiquitin, Uba6, is provided. Compositions and methods for inhibiting ubiquitin via the Uba6 pathway are provided. Methods of identifying novel inhibitors of ubiquitination are also provided. Novel RNAi molecules are also provided. |
| FILED | Wednesday, May 09, 2012 |
| APPL NO | 13/467170 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846363 | Myette et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | James R. Myette (Waltham, Massachusetts); Ram Sasisekharan (Bedford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James R. Myette (Waltham, Massachusetts); Ram Sasisekharan (Bedford, Massachusetts) |
| ABSTRACT | This invention is related, in part, to sulfatase enzymes and methods of their use. |
| FILED | Friday, October 22, 2010 |
| APPL NO | 12/910767 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 2400/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846372 | Eckstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Torsten Manfred Eckstein (Fort Collins, Colorado); Julia Mitsue Inamine Eckstein (Fort Collins, Colorado) |
| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| INVENTOR(S) | Torsten Manfred Eckstein (Fort Collins, Colorado); Julia Mitsue Inamine Eckstein (Fort Collins, Colorado) |
| ABSTRACT | The use of free, extractable lipids found in bacteria for identification of bacterial species and subspecies is described. Bacteria have been found to differ sufficiently in their extracted lipid compositions to effect identification using thin layer chromatographic techniques. Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei have been distinguished in this manner. Lipopeptides specific to Mycobacterium avium subspecies paratuberculosis, but not to the closely related bacterium Mycobacterium avium subspecies avium have also been used as a basis for bacterial subspecies identification using mass spectrometry and seroreactivity. Mass spectrometric analysis of total bacterial lipids of Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei, and mass spectrometric analysis of total bacterial lipids for Mycobacterium avium subspecies paratuberculosis and Mycobacterium avium subspecies avium, without further lipid separation, has shown that species and subspecies of bacteria may be identified using such analysis. |
| FILED | Thursday, December 02, 2010 |
| APPL NO | 12/959248 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/253.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846373 | Geisler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christoph Geisler (Laramie, Wyoming); Donald Jarvis (Laramie, Wyoming) |
| ASSIGNEE(S) | The University of Wyoming (Laramie, Wyoming) |
| INVENTOR(S) | Christoph Geisler (Laramie, Wyoming); Donald Jarvis (Laramie, Wyoming) |
| ABSTRACT | The present invention relates to new methods to promote sialylation of glycoconjugates, including recombinant glycoproteins, in glycoconjugate production systems. The invention relates to methods to promote efficient glycoconjugate sialylation in recombinant expression systems, by providing simpler and more economical ways to produce large intracellular pools of sialic acid precursors. The invention is directed to nucleic acids, vectors, and cells harboring vectors comprising nucleic acids encoding enzymes involved in the synthesis of sialic acid precursors, and cells harboring these nucleic acids in combination with nucleic acids encoding glycosyltransferases, including sialyltransferases, to facilitate the production of humanized recombinant glycoproteins in bacterial, fungal, plant, and animal cell expression systems. The engineered cells can be used to produce glycosylated proteins in virally-infected, transiently-transformed, or stably-transformed host cells, including lepidopteran insects and cultured cell lines derived from Spodoptera frugiperda, Trichoplusia ni, and Bombyx mori that can be infected by baculovirus expression vectors. |
| FILED | Friday, July 27, 2012 |
| APPL NO | 13/559912 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846387 | Russell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David W. Russell (Seattle, Washington); Roli K. Hirata (Seattle, Washington) |
| ASSIGNEE(S) | The University of Washington (Seattle, Washington) |
| INVENTOR(S) | David W. Russell (Seattle, Washington); Roli K. Hirata (Seattle, Washington) |
| ABSTRACT | This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing. |
| FILED | Tuesday, May 24, 2011 |
| APPL NO | 13/114117 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846389 | Chiorini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | John A. Chiorini (Kensington, Maryland); Robert M. Kotin (Bethesda, Maryland); Brian Safer (Silver Spring, Maryland) |
| ABSTRACT | The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles. |
| FILED | Tuesday, July 02, 2013 |
| APPL NO | 13/933382 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/320.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846392 | Basile et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lena A. Basile (Tujunga, California); Timothy Kirk Gallaher (Arcadia, California) |
| ASSIGNEE(S) | Neumedicines, Inc. (Pasadena, California) |
| INVENTOR(S) | Lena A. Basile (Tujunga, California); Timothy Kirk Gallaher (Arcadia, California) |
| ABSTRACT | The present application relates to stem cells isolated from various sources within the body of a patient or of a healthy donor and identified by the presence of the interleukin 12 (IL-12) receptor. The present application also provides methods for making and for using the stem cells. |
| FILED | Tuesday, September 27, 2011 |
| APPL NO | 13/824224 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) Original (OR) Class A61K 35/14 (20130101) A61K 35/26 (20130101) A61K 35/28 (20130101) A61K 35/38 (20130101) A61K 35/51 (20130101) A61K 38/208 (20130101) A61K 38/208 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 2501/2312 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846395 | Slukvin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Igor I. Slukvin (Verona, Wisconsin); Kyung-Dal Choi (Madison, Wisconsin); Maksym A. Vodyanyk (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Igor I. Slukvin (Verona, Wisconsin); Kyung-Dal Choi (Madison, Wisconsin); Maksym A. Vodyanyk (Madison, Wisconsin) |
| ABSTRACT | A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed. |
| FILED | Thursday, September 24, 2009 |
| APPL NO | 12/586600 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) C12N 5/0642 (20130101) Original (OR) Class C12N 5/0643 (20130101) C12N 5/0645 (20130101) C12N 2500/38 (20130101) C12N 2500/99 (20130101) C12N 2501/15 (20130101) C12N 2501/22 (20130101) C12N 2501/23 (20130101) C12N 2501/25 (20130101) C12N 2501/185 (20130101) C12N 2502/1394 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2533/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846410 | Pollack et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael G. Pollack (Durham, North Carolina); Vamsee K. Pamula (Durham, North Carolina); Ramakrishna Sista (Morrisville, North Carolina); Arjun Sudarsan (Cary, North Carolina) |
| ASSIGNEE(S) | Advanced Liquid Logic, Inc. (Research Triangle Park, North Carolina) |
| INVENTOR(S) | Michael G. Pollack (Durham, North Carolina); Vamsee K. Pamula (Durham, North Carolina); Ramakrishna Sista (Morrisville, North Carolina); Arjun Sudarsan (Cary, North Carolina) |
| ABSTRACT | The present invention relates to bead incubating and washing on a droplet actuator. Methods for incubating magnetically responsive beads that are labeled with primary antibody, a sample (i.e., analyte), and secondary reporter antibodies on a magnet, on and off a magnet, and completely off a magnet are provided. Also provided are methods for washing magnetically responsive beads using shape-assisted merging of droplets. Also provided are methods for shape-mediated splitting, transporting, and dispensing of a sample droplet that contains magnetically responsive beads. The apparatuses and methods of the invention provide for rapid time to result and optimum detection of an analyte in an immunoassay. |
| FILED | Friday, November 15, 2013 |
| APPL NO | 14/081376 |
| ART UNIT | 1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 11/0071 (20130101) B01F 13/0071 (20130101) B01F 13/0076 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 3/502792 (20130101) B01L 7/52 (20130101) B01L 7/525 (20130101) B01L 2200/027 (20130101) B01L 2200/0668 (20130101) B01L 2300/089 (20130101) B01L 2300/0654 (20130101) B01L 2300/0816 (20130101) B01L 2300/0861 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2300/1827 (20130101) B01L 2400/043 (20130101) B01L 2400/0406 (20130101) B01L 2400/0415 (20130101) B01L 2400/0421 (20130101) B01L 2400/0424 (20130101) B01L 2400/0427 (20130101) B01L 2400/0436 (20130101) B01L 2400/0442 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/02 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2035/1046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846414 | Sista et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ramakrishna Sista (Morrisville, North Carolina); Vamsee K. Pamula (Durham, North Carolina); Arjun Sudarsan (San Diego, California); Vijay Srinivasan (San Diego, California); Michael G. Pollack (San Diego, California); Richard B. Fair (Durham, North Carolina); Allen E. Eckhardt (San Diego, California) |
| ASSIGNEE(S) | Advanced Liquid Logic, Inc. (Research Triangle Park, North Carolina); Duke University (Durham, North Carolina) |
| INVENTOR(S) | Ramakrishna Sista (Morrisville, North Carolina); Vamsee K. Pamula (Durham, North Carolina); Arjun Sudarsan (San Diego, California); Vijay Srinivasan (San Diego, California); Michael G. Pollack (San Diego, California); Richard B. Fair (Durham, North Carolina); Allen E. Eckhardt (San Diego, California) |
| ABSTRACT | The present invention provides for the detection of cardiac markers on a droplet actuator. An aspect provides a method of assaying a cardiac marker in a biological sample from a subject, the method including providing a droplet actuator, loading the biological sample and assay reagents on the droplet actuator, executing droplet operations to create sample droplets from the sample and reagent droplets from the reagents on the droplet actuator, and executing droplet operations using the sample droplets and reagent droplets to produce a detectable signal indicative of the quantity of the cardiac marker in the biological sample. Still other aspects are provided. |
| FILED | Tuesday, September 29, 2009 |
| APPL NO | 12/569725 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 33/54366 (20130101) G01N 2333/58 (20130101) G01N 2333/4712 (20130101) G01N 2800/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846578 | McCray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paul McCray (Iowa City, Iowa); Morgan Maeder (Brookline, Massachusetts); Jae Keith Joung (Winchester, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts); University of Iowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Paul McCray (Iowa City, Iowa); Morgan Maeder (Brookline, Massachusetts); Jae Keith Joung (Winchester, Massachusetts) |
| ABSTRACT | The present invention provides new zinc finger proteins and zinc finger nuclease (ZFNs) that find particular using in repairing the cystic fibrosis transmembrane conductance regulator (CFTR) gene. |
| FILED | Friday, October 15, 2010 |
| APPL NO | 12/905824 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4702 (20130101) C07K 14/4703 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/1082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846607 | Edwards et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David A. Edwards (Boston, Massachusetts); Jennifer Fiegel (Arlington, Massachusetts); Jean Sung (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Edwards (Boston, Massachusetts); Jennifer Fiegel (Arlington, Massachusetts); Jean Sung (Cambridge, Massachusetts) |
| ABSTRACT | Formulations have been developed to treat or reduce the spread of respiratory infections, especially chronic or drug resistant infections, particularly tuberculosis (TB), severe acute respiratory syndrome (SARS), meningococcal meningitis, Respiratory syncytial virus (RSV), influenza, and small pox. Formulations include a drug or vaccine in the form of a microparticle, nanoparticle, or aggregate of nanoparticles, and, optionally, a carrier, which can be delivered by inhalation. Giving the drugs via an inhaler sidesteps the problems associated with oral or injectable drugs by bypassing the stomach and liver, and delivering the medication directly into the lungs. In one embodiment, the particle containing the agent is a large porous aerosol particle (LPPs). In another embodiment, the particles are nanoparticles, which can be administered as porous nanoparticle aggregates with micron diameters that disperse into nanoparticles following administration. Optionally, the nanoparticles are coated, such as with a surfactant or protein coating. The formulation may be administered as a powder or administered as a solution or via an enteral or non-pulmonary parenteral route of administration. The formulation is preferably administered as a pulmonary formulation. In the preferred embodiment for treatment of TB, the vaccine is a BCG vaccine that is stable at room temperature, or is an antibiotic effective against TB, such as capreomycin or PA-824, loaded at a very high percentage into the microparticles or nanoparticles. In one embodiment, a patient is treated with formulations delivering both antibiotic and vaccine. |
| FILED | Wednesday, October 19, 2005 |
| APPL NO | 11/720595 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0075 (20130101) Original (OR) Class A61K 9/1617 (20130101) A61K 9/1694 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 514/924 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846616 | Sachdeva et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mandip Singh Sachdeva (Tallahassee, Florida); Cheryl Armstrong (Little Rock, Alaska); Melissa A. Brown (Little Rock, Arkansas) |
| ASSIGNEE(S) | Florida Agricultural and Mechanical University (Tallahassee, Florida); The Board of Trustees at the University of Arkansas (Little Rock, Arkansas) |
| INVENTOR(S) | Mandip Singh Sachdeva (Tallahassee, Florida); Cheryl Armstrong (Little Rock, Alaska); John Ansel (Little Rock, Arkansas) |
| ABSTRACT | A method is presented for treating an inflammatory skin disorder in a human comprising: topically applying to the skin a composition comprising alpha-melanocyte stimulating hormone (αMSH) or an αMSH analog in an amount effective to reduce skin inflammation in the human. |
| FILED | Tuesday, November 09, 2010 |
| APPL NO | 12/942369 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/10.700 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846619 | Dutton |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | P. Leslie Dutton (Media, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | P. Leslie Dutton (Media, Pennsylvania) |
| ABSTRACT | This invention provides heme-containing peptides capable of binding molecular oxygen at room temperature. These compounds may be useful in the absorption of molecular oxygen from molecular oxygen-containing atmospheres. Also included in the invention are methods for treating an oxygen transport deficiency in a mammal. |
| FILED | Thursday, March 04, 2010 |
| APPL NO | 13/254596 |
| ART UNIT | 1675 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/805 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846624 | Chaikof et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Elliot L. Chaikof (Atlanta, Georgia); Vincent P. Conticello (Decatur, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Elliot L. Chaikof (Atlanta, Georgia); Vincent P. Conticello (Decatur, Georgia) |
| ABSTRACT | In an embodiment, a number of synthetic protein triblock copolymers are provided comprising first and second end hydrophobic blocks separated by a central hydrophilic block. In particular, the synthetic proteins are elastin-mimetic proteins having improved mechanical characteristics and related methods of making the proteins with the capability of providing precise control over the mechanical properties. Provided are proteins used in a number of medical devices such as artificial blood vessels, shunts, stents or as embolic agents in situations where it is desired to stop or reduce blood flow or pressure in a localized region. |
| FILED | Tuesday, September 11, 2007 |
| APPL NO | 12/440670 |
| ART UNIT | 1676 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/32 (20130101) A61L 27/227 (20130101) A61L 31/047 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846629 | Desprez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pierre-Yves Desprez (Richmond, California); Judith Campisi (Berkeley, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); California Pacific Medical Center Research Institute (San Francisco, California) |
| INVENTOR(S) | Pierre-Yves Desprez (Richmond, California); Judith Campisi (Berkeley, California) |
| ABSTRACT | A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression. |
| FILED | Tuesday, December 02, 2008 |
| APPL NO | 12/326832 |
| ART UNIT | 1674 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2300/156 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5743 (20130101) G01N 33/57407 (20130101) G01N 33/57415 (20130101) G01N 33/57434 (20130101) G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846643 | Hostetler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Karl Y. Hostetler (Del Mar, California); James R. Beadle (San Diego, California); Nadejda Valiaeva (San Diego, California) |
| ABSTRACT | There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are also provided methods of using the disclosed compounds for inhibiting viral RNA-dependent RNA polymerase, inhibiting viral reverse transcriptase, inhibiting replication of virus, including hepatitis C virus or a human retrovirus, and treating a subject infected with a virus, including hepatitis C virus or a human retrovirus. |
| FILED | Thursday, October 11, 2012 |
| APPL NO | 13/649671 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/522 (20130101) A61K 31/675 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65121 (20130101) C07F 9/65616 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846653 | Malafa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | Mokenge P. Malafa (Tampa, Florida); Said M. Sebti (Tampa, Florida) |
| ABSTRACT | Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds are shown both in vitro and in vivo using several human pancreatic cancer cell lines and MIA-PACA2 human pancreatic cancer cells xenografted in nude mice. Also disclosed are methods of testing the efficacy of potential chemotherapeutic agents by measuring their effect on surrogate endpoint biomarkers, such as Ki-67 and p27. Associated compounds are also disclosed. |
| FILED | Tuesday, October 16, 2012 |
| APPL NO | 13/653108 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/183 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846667 | Gupta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vineet Gupta (Pinecrest, Florida); M. Amin Arnaout (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Vineet Gupta (Pinecrest, Florida); M. Amin Arnaout (Chestnut Hill, Massachusetts) |
| ABSTRACT | The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency. |
| FILED | Thursday, September 13, 2012 |
| APPL NO | 13/614046 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/225.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846684 | Larsen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Scott Larsen (South Lyon, Michigan); Janice Sindac (Ann Arbor, Michigan); Scott Barraza (Ann Arbor, Michigan); David J. Miller (Chelsea, Michigan) |
| ASSIGNEE(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Scott Larsen (South Lyon, Michigan); Janice Sindac (Ann Arbor, Michigan); Scott Barraza (Ann Arbor, Michigan); David J. Miller (Chelsea, Michigan) |
| ABSTRACT | The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as inhibitors of arboviruses. |
| FILED | Monday, March 19, 2012 |
| APPL NO | 13/423647 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 401/06 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 471/04 (20130101) C07D 491/048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846693 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Peng Li (New York, New York); Jun Zhao (New York, New York); Hailin Zheng (New York, New York) |
| ASSIGNEE(S) | Intra-Cellular Therapies, Inc. (New York, New York) |
| INVENTOR(S) | Peng Li (New York, New York); Jun Zhao (New York, New York); Hailin Zheng (New York, New York) |
| ABSTRACT | 1- or 2- or 7-(substituted)-3-(optionally hetero)arylamino-[1H,2H]-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives, in free, salt or prodrug form, are useful as pharmaceuticals, particularly as phosphodiesterase 1 inhibitors, useful for the treatment of diseases involving disorders of the dopamine D1 receptor intracellular pathway, such as Parkinson's disease, depression, narcolepsy and damage to cognitive function, e.g., in schizophrenia or disorders that may be ameliorated through enhanced progesterone-signaling pathway, e.g., female sexual dysfunction. |
| FILED | Saturday, December 06, 2008 |
| APPL NO | 12/746231 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846697 | Carson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dennis A. Carson (La Jolla, California); Howard B. Cottam (Escondido, California); Guangyi Jin (Berkeley, California); Christina C. N. Wu (Escondido, California); Suzanne Grimshaw (Poway, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Dennis A. Carson (La Jolla, California); Howard B. Cottam (Escondido, California); Guangyi Jin (Berkeley, California); Christina C. N. Wu (Escondido, California); Kenji Takabayashi (Poway, California) |
| ABSTRACT | The present invention provides purine analog compounds, as well as compositions and methods of using them, for example, to prevent or treat various diseases and disorders in human and non-human animals. For example, the invention provides for a compound having formula II: |
| FILED | Monday, April 23, 2007 |
| APPL NO | 12/302738 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/263.370 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846707 | Turkson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | James Turkson (Orlando, Florida); Patrick Gunning (Mississauga, Canada) |
| ASSIGNEE(S) | Univeristy of Central Florida Research Foundation, Inc. (Orlando, Florida); The Governing Council of the University of Toronto (Toronto, Ontario, Canada) |
| INVENTOR(S) | James Turkson (Orlando, Florida); Patrick Gunning (Mississauga, Canada) |
| ABSTRACT | In one aspect, the invention relates to substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Tuesday, August 02, 2011 |
| APPL NO | 13/813916 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) Acyclic or Carbocyclic Compounds C07C 311/19 (20130101) C07C 311/29 (20130101) C07C 311/42 (20130101) C07C 311/46 (20130101) Original (OR) Class C07C 323/49 (20130101) C07C 2101/14 (20130101) Heterocyclic Compounds C07D 207/48 (20130101) C07D 211/26 (20130101) C07D 211/96 (20130101) C07D 213/42 (20130101) C07D 215/36 (20130101) C07D 233/84 (20130101) C07D 401/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846724 | Sinclair et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David A. Sinclair (Chestnut Hill, Massachusetts); Maria Alexander-Bridges (West Newton, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David A. Sinclair (Chestnut Hill, Massachusetts); Maria Alexander-Bridges (West Newton, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively. |
| FILED | Wednesday, July 27, 2011 |
| APPL NO | 13/192011 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/05 (20130101) A61K 31/12 (20130101) Original (OR) Class A61K 31/353 (20130101) A61K 31/7048 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 514/866 (20130101) Y10S 514/909 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846727 | Rossignol et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jean-Francois Rossignol (St. Petersburg, Florida); J. Edward Semple (Tampa, Florida) |
| ASSIGNEE(S) | Romark Laboratories, L.C. (Tampa, Florida) |
| INVENTOR(S) | Jean-Francois Rossignol (St. Petersburg, Florida); J. Edward Semple (Tampa, Florida) |
| ABSTRACT | A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses. |
| FILED | Tuesday, May 11, 2010 |
| APPL NO | 12/777383 |
| ART UNIT | 1672 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 231/40 (20130101) C07D 231/44 (20130101) C07D 233/88 (20130101) C07D 233/90 (20130101) C07D 249/14 (20130101) C07D 261/14 (20130101) C07D 263/48 (20130101) C07D 271/07 (20130101) C07D 271/113 (20130101) C07D 275/03 (20130101) C07D 277/46 (20130101) Original (OR) Class C07D 277/56 (20130101) C07D 285/08 (20130101) C07D 285/135 (20130101) C07D 403/06 (20130101) C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 409/06 (20130101) C07D 413/12 (20130101) C07D 417/06 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846742 | Ambron et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Richard Ambron (Lake Success, New York); Ying-Ju Sung (Northvale, New Jersey); Jeremy Greenwood (Brooklyn, New York); Leah Frye (Portland, Oregon); Shi-Xian Deng (White Plains, New York); Yuli Xie (New York, New York); Donald W. Landry (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Richard Ambron (Lake Success, New York); Ying-Ju Sung (Northvale, New Jersey); Jeremy Greenwood (Brooklyn, New York); Leah Frye (Portland, Oregon); Shi-Xian Deng (White Plains, New York); Yuli Xie (New York, New York); Donald W. Landry (New York, New York) |
| ABSTRACT | The present invention relates to compounds that may be used to inhibit activation of protein kinase G (“PKG”). It is based, at least in part, on the discovery of the tertiary structure of PKG and the identification of molecules that either bind to the active site of PKG and/or are analogs of balanol. |
| FILED | Wednesday, February 14, 2007 |
| APPL NO | 11/674965 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/335 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846747 | Goldfarb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David S. Goldfarb (Victor, New York); Joseph A. Maddry (Birmingham, Alabama); Lynn Rasmussen (Odenville, Alabama); Ellie Lucille White (Birmingham, Alabama); Krister Wennerberg (Helsinki, Norway) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York); Southern Research Institute (Birmingham, Alabama) |
| INVENTOR(S) | David S. Goldfarb (Victor, New York); Joseph A. Maddry (Birmingham, Alabama); Lynn Rasmussen (Odenville, Alabama); Ellie Lucille White (Birmingham, Alabama); Krister Wennerberg (Helsinki, Norway) |
| ABSTRACT | Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation. |
| FILED | Wednesday, November 17, 2010 |
| APPL NO | 13/510166 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 49/403 (20130101) C07C 49/417 (20130101) C07C 49/543 (20130101) C07C 49/553 (20130101) C07C 49/567 (20130101) C07C 49/573 (20130101) C07C 49/577 (20130101) C07C 49/613 (20130101) C07C 49/657 (20130101) Original (OR) Class C07C 49/753 (20130101) C07C 49/792 (20130101) C07C 69/743 (20130101) C07C 69/757 (20130101) C07C 225/22 (20130101) C07C 235/82 (20130101) C07C 2101/02 (20130101) C07C 2101/08 (20130101) C07C 2101/14 (20130101) C07C 2102/42 (20130101) Heterocyclic Compounds C07D 209/12 (20130101) C07D 307/46 (20130101) C07D 307/54 (20130101) C07D 317/54 (20130101) C07D 319/18 (20130101) C07D 333/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846764 | Sweeney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William E. Sweeney (Waukesha, Wisconsin); Ellis D. Avner (Milwaukee, Wisconsin); Richard J. Roman (Brookfield, Wisconsin) |
| ASSIGNEE(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| INVENTOR(S) | William E. Sweeney (Waukesha, Wisconsin); Ellis D. Avner (Milwaukee, Wisconsin); Richard J. Roman (Brookfield, Wisconsin) |
| ABSTRACT | The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to preferentially reduce the proliferation of cystic epithelial cells over normal epithelial cells such as tubule epithelial cells in the kidney or bile duct. The present invention also provides a method for preventing or treating autosomal dominant polycystic kidney disease (ADPKD), autosomal recessive polycystic kidney disease (ARPKD), ARPKD associated congenital hepatic fibrosis, ARPKD associated Caroli's disease, or cholangiocarcinoma in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to prevent or treat the disease. |
| FILED | Thursday, September 13, 2007 |
| APPL NO | 11/900722 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/633 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846777 | Bowman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christopher Bowman (Boulder, Colorado); Neil Cramer (Boulder, Colorado); Robin Shandas (Boulder, Colorado); Devatha P. Nair (Lakewood, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| INVENTOR(S) | Christopher Bowman (Boulder, Colorado); Neil Cramer (Boulder, Colorado); Robin Shandas (Boulder, Colorado); Devatha P. Nair (Lakewood, Colorado) |
| ABSTRACT | A variety of biomedical devices are provided which include thiol-ene or thiol-yne shape memory polymers. The biomedical devices of the invention are capable of exhibiting shape memory behavior at physiological temperatures and may be used in surgical procedures. Methods of making the devices of the invention are also provided. |
| FILED | Wednesday, April 22, 2009 |
| APPL NO | 12/988983 |
| ART UNIT | 1763 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 59/16 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/46 (20130101) C08F 2/48 (20130101) C08F 2/50 (20130101) C08F 290/067 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/672 (20130101) Original (OR) Class Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 175/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846850 | Uhrich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, the State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, the State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Kathryn E. Uhrich (New Brunswick, New Jersey); Sarah M. Sparks (New Brunswick, New Jersey); Li Gu (New Brunswick, New Jersey); Alex Harmon (New Brunswick, New Jersey); Charles M. Roth (New Brunswick, New Jersey); Carolyn Federici (New Brunswick, New Jersey) |
| ABSTRACT | The invention provides amphiphilic macromolecules that are useful for delivering nucleic acids to cells and that are useful as delivery agents for gene therapy. |
| FILED | Wednesday, March 13, 2013 |
| APPL NO | 13/801562 |
| ART UNIT | 1671 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Synthetic resins or natural rubbers 528/322 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846859 | Pasqualini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Renata Pasqualini (Houston, Texas); Wadih Arap (Houston, Texas); Mikhail G. Kolonin (Houston, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Renata Pasqualini (Houston, Texas); Wadih Arap (Houston, Texas); Mikhail G. Kolonin (Houston, Texas) |
| ABSTRACT | The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides comprise part or all of SEQ ID NO:5-11, SEQ ID NO:13-22 or SEQ ID NO:144. The peptides may be attached to various therapeutic agents for targeted delivery. Adipose-targeting peptides may be used in methods for weight control, inducing weight loss and treating lipodystrophy syndrome. Adipose-targeting may also be accomplished using other binding moieties selectively targeted to adipose receptors, such as a prohibitin receptor protein complex. Placenta-targeting peptides may be used to interfere with pregnancy, induce labor and/or for targeted delivery of therapeutic agents to placenta and/or fetus. In other embodiments, receptors identified by binding to placenta-targeting peptides may be used to screen compounds for potential teratogenicity. An exemplary placental receptor is FcRn/β2M, and compounds that bind to FcRn/β2M are potential teratogens. |
| FILED | Thursday, July 26, 2012 |
| APPL NO | 13/559222 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/70 (20130101) A61K 38/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846860 | Murphy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | William L. Murphy (Waunakee, Wisconsin); Jae Sung Lee (Middleton, Wisconsin); Mark D. Markel (Middleton, Wisconsin); Ben K. Graf (Madison, Wisconsin) |
| ABSTRACT | A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation. |
| FILED | Tuesday, February 19, 2013 |
| APPL NO | 13/770085 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/18 (20130101) Original (OR) Class B05D 1/28 (20130101) Peptides C07K 14/50 (20130101) C07K 14/51 (20130101) C07K 14/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846866 | Carrico et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Isaac S. Carrico (Stony Brook, New York); Brian L. Carlson (Richmond, California); Peng Wu (Berkeley, California); Carolyn Bertozzi (Berkeley, California) |
| ABSTRACT | The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide. |
| FILED | Friday, December 07, 2012 |
| APPL NO | 13/708528 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 1/006 (20130101) C07K 1/13 (20130101) C07K 1/1072 (20130101) Original (OR) Class C07K 14/00 (20130101) C07K 16/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/96 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) C12P 21/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846867 | Payne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aimee S. Payne (Merion Station, Pennsylvania); John R. Stanley (Gladwyne, Pennsylvania); Donald L. Siegel (Lansdale, Pennsylvania); Jun Yamagami (Philadelphia, Pennsylvania); Ken Ishii (Tokyo, Japan) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Aimee S. Payne (Merion Station, Pennsylvania); John R. Stanley (Gladwyne, Pennsylvania); Donald L. Siegel (Lansdale, Pennsylvania); Jun Yamagami (Philadelphia, Pennsylvania); Ken Ishii (Tokyo, Japan) |
| ABSTRACT | This invention relates to compositions and methods for the use of anti-autoimmune reagents that specifically bind to anti-desmoglein antibodies, which are responsible for pemphigus foliaceus. In addition, the invention relates to methods and compositions for inhibiting the expression or function of a variable region of an anti-desmoglein (anti-Dsg) pathogenic autoantibody. |
| FILED | Friday, May 09, 2008 |
| APPL NO | 12/666265 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Natural resins or derivatives; peptides or proteins; lignins or reaction products thereof 530/387.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846886 | Jarvis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Donald L. Jarvis (Laramie, Wyoming); Christoph Geisler (Laramie, Wyoming) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming) |
| INVENTOR(S) | Donald L. Jarvis (Laramie, Wyoming); Christoph Geisler (Laramie, Wyoming) |
| ABSTRACT | A transgenic insect cell line for production of elevated levels of recombinant glycoproteins comprising mammalian-like N-glycans is provided. Also disclosed are nucleic acid sequences encoding β-N-acetylglucosaminidases. |
| FILED | Friday, December 12, 2008 |
| APPL NO | 12/746808 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Enzymes C12Y 302/01096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846887 | Zhan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chang-Guo Zhan (Lexington, Kentucky); Fang Zheng (Lexington, Kentucky); Wenchao Yang (Lexington, Kentucky) |
| ASSIGNEE(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| INVENTOR(S) | Chang-Guo Zhan (Lexington, Kentucky); Fang Zheng (Lexington, Kentucky); Wenchao Yang (Lexington, Kentucky) |
| ABSTRACT | Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration. |
| FILED | Thursday, May 24, 2012 |
| APPL NO | 13/479899 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Organic compounds 536/23.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846889 | Wolfe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Darren P. Wolfe (Pittsburgh, Pennsylvania); Joseph C. Glorioso (Pittsburgh, Pennsylvania); David J. Fink (Ann Arbor, Michigan) |
| ASSIGNEE(S) | Darren P. Wolfe (Pittsburgh, Pennsylvania); Joseph C. Glorioso (Pittsburgh, Pennsylvania); Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Darren P. Wolfe (Pittsburgh, Pennsylvania); Joseph C. Glorioso (Pittsburgh, Pennsylvania); David J. Fink (Ann Arbor, Michigan) |
| ABSTRACT | The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GNP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect. |
| FILED | Wednesday, September 29, 2010 |
| APPL NO | 12/893352 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Peptides C07K 5/1016 (20130101) Original (OR) Class C07K 7/22 (20130101) C07K 14/67 (20130101) C07K 14/70 (20130101) C07K 14/695 (20130101) C07K 2319/50 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/16643 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 33/9486 (20130101) G01N 2800/2842 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846890 | Reguera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gemma Reguera (Lansing, Michigan); Rebecca Steidl (Williamston, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Gemma Reguera (Lansing, Michigan); Rebecca Steidl (Williamston, Michigan) |
| ABSTRACT | The application describes electrically conductive nanowires, as well as genetically and/or chemically modified nanowires with modified conductive, adhesive and/or coupling properties. |
| FILED | Tuesday, August 30, 2011 |
| APPL NO | 13/221495 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Original (OR) Class Peptides C07K 14/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846909 | Gelbard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Harris A. Gelbard (Pittsford, New York); Stephen Dewhurst (Rochester, New York); Val S. Goodfellow (Encinitas, California); Torsten Wiemann (Encinitas, California); Satheesh Babu Ravula (San Diego, California); Colin J. Loweth (San Marcos, California) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Harris A. Gelbard (Pittsford, New York); Stephen Dewhurst (Rochester, New York); Val S. Goodfellow (Encinitas, California); Torsten Wiemann (Encinitas, California); Satheesh Babu Ravula (San Diego, California); Colin J. Loweth (San Marcos, California) |
| ABSTRACT | Provided are compounds having an inhibitory effect on kinases including Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders that comprise the inhibition of Mixed Lineage Kinases. |
| FILED | Tuesday, May 24, 2011 |
| APPL NO | 13/698829 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Organic compounds 544/118 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846932 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Lin Chen (La Canada, California); Nimanthi Jayathilaka (Los Angeles, California); Aidong Han (Los Angeles, California); Nicos A. Petasis (Hacienda Heights, California) |
| ABSTRACT | Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof. |
| FILED | Wednesday, March 13, 2013 |
| APPL NO | 13/801380 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/167 (20130101) A61K 31/444 (20130101) Acyclic or Carbocyclic Compounds C07C 233/43 (20130101) Original (OR) Class Heterocyclic Compounds C07D 213/40 (20130101) Peptides C07K 2299/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6875 (20130101) G01N 2500/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846937 | Crooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Peter Crooks (Nicholasville, Kentucky); Linda P. Dwoskin (Lexington, Kentucky); Guangrong Zheng (Lexington, Kentucky); Sangeetha Sumithran (Lexington, Kentucky); Zhenfa Zheng (Lexington, Kentucky) |
| ASSIGNEE(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| INVENTOR(S) | Peter Crooks (Nicholasville, Kentucky); Linda P. Dwoskin (Lexington, Kentucky); Guangrong Zheng (Lexington, Kentucky); Sangeetha Sumithran (Lexington, Kentucky); Zhenfa Zheng (Lexington, Kentucky) |
| ABSTRACT | Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders. |
| FILED | Friday, June 15, 2007 |
| APPL NO | 12/304955 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 17/16 (20130101) C07C 17/16 (20130101) C07C 22/04 (20130101) Heterocyclic Compounds C07D 213/20 (20130101) Original (OR) Class C07D 213/30 (20130101) C07D 215/10 (20130101) C07D 217/10 (20130101) C07D 401/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846939 | Grubbs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert H. Grubbs (South Pasadena, California); Matthias Scholl (Arcadia, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Robert H. Grubbs (South Pasadena, California); Matthias Scholl (Arcadia, California) |
| ABSTRACT | The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same. The inventive catalysts are wherein: M is ruthenium or osmium; X and X1 are each independently an anionic ligand; L is a neutral electron donor ligand; and, R, R1 R6, R7, R8, and R9 are each independently hydrogen or a substituent selected for the group consisting of C1 C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 alkoxycarbonyl, C1-C20 alkyithiol, aryl thiol, C1-C20 alkylsulfortyl and C1-C20 alkylsulfinyl, the substituent optionally substituted with one or more moieties selected from the group consisting of C1-C20 alkyl, C1-C10 alkoxy, aryl, and a functional group. The inclusion of an imidazolidine ligand to the previously described ruthenium or osmium catalysts has been found to dramatically improve the properties of these complexes. |
| FILED | Tuesday, June 12, 2012 |
| APPL NO | 13/494708 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0046 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847003 | Sanna |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pietro P. Sanna (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pietro P. Sanna (San Diego, California) |
| ABSTRACT | The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may be used to prevent or treat drug addiction or ameliorate the craving for an addictive drug. The invention also provides methods for identifying agents that may be used to prevent or treat drug addiction, or ameliorate the craving for an addictive drug. |
| FILED | Wednesday, January 11, 2012 |
| APPL NO | 13/348596 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Multicellular living organisms and unmodified parts thereof and related processes 8/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848199 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wonshik Choi (Somerville, Massachusetts); Ramachandra Rao Dasari (Schererville, Indiana); Christopher M. Fang-Yen (Brookline, Massachusetts); Michael S. Feld (Jamaica Plain, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Wonshik Choi (Somerville, Massachusetts); Ramachandra Rao Dasari (Schererville, Indiana); Christopher M. Fang-Yen (Brookline, Massachusetts); Michael S. Feld (Jamaica Plain, Massachusetts) |
| ABSTRACT | The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering. |
| FILED | Thursday, July 10, 2008 |
| APPL NO | 12/218029 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Original (OR) Class G01N 21/51 (20130101) G01N 21/6458 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848867 | Funk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tobias Funk (Martinez, California); Steve Denis Burion (San Francisco, California); Kate Leeann Bechtel (Pleasant Hill, California); Joseph Anthony Heanue (Oakland, California); Brian Patrick Wilfley (Los Altos, California); Augustus Percival Lowell (Durham, New Hampshire) |
| ASSIGNEE(S) | Triple Ring Technologies, Inc. (Newark, California) |
| INVENTOR(S) | Tobias Funk (Martinez, California); Steve Denis Burion (San Francisco, California); Kate Leeann Bechtel (Pleasant Hill, California); Joseph Anthony Heanue (Oakland, California); Brian Patrick Wilfley (Los Altos, California); Augustus Percival Lowell (Durham, New Hampshire) |
| ABSTRACT | The present invention pertains to an apparatus and method for adaptive exposure in imaging systems. An x-ray source for producing x-ray radiation and an x-ray detector for measuring amount of x-ray radiation passing through the human patient and striking the detector can be used. A tomographic image of the human patient or a tomosynthetic image of the human patient can be generated. Region of interest filtering and equalization filtering can be utilized. Filtering can be accomplished with a mechanical shield or shutter or with electronic control of the x-ray source. |
| FILED | Wednesday, November 23, 2011 |
| APPL NO | 13/304030 |
| ART UNIT | 2882 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/107 (20130101) A61B 6/405 (20130101) A61B 6/469 (20130101) A61B 6/487 (20130101) A61B 6/504 (20130101) A61B 6/542 (20130101) Original (OR) Class A61B 6/4028 (20130101) A61B 6/4035 (20130101) A61B 6/4241 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 35/08 (20130101) H01J 35/14 (20130101) H01J 2235/087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849002 | Chinn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Garry Chinn (San Mateo, California); Peter D. Olcott (Stanford, California); Craig S. Levin (Palo Alto, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Garry Chinn (San Mateo, California); Peter D. Olcott (Stanford, California); Craig S. Levin (Palo Alto, California) |
| ABSTRACT | Compressed sensing (CS) estimation approaches rely on a priori sparsity to significantly reduce the number of samples needed to provide high sampling fidelity, relative to the normal Shannon-Nyquist limit. Accordingly, CS approaches are of considerable interest for detector multiplexing in applications which have inherently sparse signals (e.g., the two correlated photon detection events in PET imaging). However, CS approaches also tend to fare poorly in the presence of noise, which has limited their applicability in practice. In this work, we show that CS estimation can be used to provide an estimate of the support of an image. This estimated support is then used as a constraint for maximum likelihood image reconstruction. This approach has robust noise performance and provides high reconstruction fidelity. |
| FILED | Thursday, July 07, 2011 |
| APPL NO | 13/808063 |
| ART UNIT | 2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/037 (20130101) A61B 6/5205 (20130101) Image Data Processing or Generation, in General G06T 11/003 (20130101) Original (OR) Class G06T 11/006 (20130101) G06T 2211/436 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849373 | Keall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paul J. Keall (Stanford, California); Amit Sawant (Los Altos, California); Peter Maxim (Palo Alto, California); Yelin Suh (Palo Alto, California); Lei Xing (Palo Alto, California); Billy W. Loo, Jr. (Foster City, California); Byung Chul Cho (Palo Alto, California) |
| ASSIGNEE(S) | Stanford University (Palo Alto, California) |
| INVENTOR(S) | Paul J. Keall (Stanford, California); Amit Sawant (Los Altos, California); Peter Maxim (Palo Alto, California); Yelin Suh (Palo Alto, California); Lei Xing (Palo Alto, California); Billy W. Loo, Jr. (Foster City, California); Byung Chul Cho (Palo Alto, California) |
| ABSTRACT | A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal. |
| FILED | Monday, May 12, 2008 |
| APPL NO | 12/119464 |
| ART UNIT | 3777 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 6/06 (20130101) A61B 6/12 (20130101) A61B 6/032 (20130101) Original (OR) Class A61B 6/541 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849407 | Danilov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yuri P. Danilov (Middleton, Wisconsin); Mitchell E. Tyler (Madison, Wisconsin); Kurt A. Kaczmarek (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuri P. Danilov (Middleton, Wisconsin); Mitchell E. Tyler (Madison, Wisconsin); Kurt A. Kaczmarek (Madison, Wisconsin) |
| ABSTRACT | In a patient suffering from neural impairment, stimulation is provided to sensory surfaces of the face and/or neck, or more generally to areas of the body that stimulate the trigeminal nerve, while performing an activity intended to stimulate a brain function to be rehabilitated. The simulation may then be continued after the performance of the activity has ceased. It has been found that the patient's performance of the activity is then improved after stimulation has ceased. Moreover, it tends to improve to a greater extent, and/or for a longer time, when the post-activity stimulation is applied, as compared to when post-activity stimulation is not applied. |
| FILED | Sunday, January 04, 2009 |
| APPL NO | 12/348301 |
| ART UNIT | 3762 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Surgery: Light, thermal, and electrical application 67/45 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 08844133 | Fuller |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jerome K. Fuller (Van Nuys, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Jerome K. Fuller (Van Nuys, California) |
| ABSTRACT | A hybrid rocket motor is manufactured by photopolymerizing the solid fuel grain in a stereolithography method, wherein fuel grains in a plastic matrix are deposited in layers for building a solid fuel rocket body in three dimensions for improved performance and for a compact design, |
| FILED | Monday, July 23, 2012 |
| APPL NO | 13/555829 |
| ART UNIT | 3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 67/0051 (20130101) Jet-propulsion Plants F02K 9/14 (20130101) F02K 9/36 (20130101) F02K 9/72 (20130101) Original (OR) Class Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08844262 | Sutterfield |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David Levi Sutterfield (Greenwood, Indiana) |
| ASSIGNEE(S) | Rolls-Royce North American Technologies, Inc. (Indianapolis, Indiana) |
| INVENTOR(S) | David Levi Sutterfield (Greenwood, Indiana) |
| ABSTRACT | A gas turbine engine is provided having an offtake passage that in one form is capable of extracting a bypass flow from the engine. The airflow traversing the offtake passage is introduced to an exhaust flow of the gas turbine engine through an offtake outlet. The offtake outlet includes an airflow member that is moveable. A nozzle is also provided for exhaust from the gas turbine engine. In one form the nozzle includes moveable duct members. Flows exiting the offtake outlet and the nozzle can be combined after passing the airflow member and the moveable duct members, respectively. |
| FILED | Tuesday, December 21, 2010 |
| APPL NO | 12/974995 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/04 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 9/18 (20130101) Jet-propulsion Plants F02K 1/09 (20130101) F02K 3/02 (20130101) Original (OR) Class F02K 3/06 (20130101) F02K 3/075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08844298 | Woidtke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alex Woidtke (Bozeman, Montana); Peter B. Sellin (Bozemin, Montana); Luke Mauritsen (Belgrade, Montana); David Snow (Bozeman, Montana) |
| ASSIGNEE(S) | S2 Corporation (Bozeman, Missouri) |
| INVENTOR(S) | Alex Woidtke (Bozeman, Montana); Peter B. Sellin (Bozemin, Montana); Luke Mauritsen (Belgrade, Montana); David Snow (Bozeman, Montana) |
| ABSTRACT | A sample mounting apparatus for a cryo-cooler is provided having a housing with an outer wall surface for connecting to the cryo-cooler, and an inner wall surface. An inert gas is sealed inside the housing for thermal transfer, and a delicate mount is attached to the inner wall surface of the housing for supporting the sample and substantially preventing vibrations from being transferred to the sample from the cryo-cooler. |
| FILED | Wednesday, November 18, 2009 |
| APPL NO | 12/621306 |
| ART UNIT | 3744 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 19/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08844444 | Hooke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America as represented by the Secretary of the Army (Dover, New Jersey) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Ryan Hooke (Hopatcong, New Jersey); Tyler Myers (Hopatcong, New Jersey) |
| ABSTRACT | A reusable test projectile may be used for spinning and non-spinning shots in a soft catch system. The projectile may include a body having an integrally formed base and a removable nose. The body may define a generally cylindrical open area between the nose and the base. A generally circular cargo retaining ring may be disposed in the open area, normal to a longitudinal axis of the projectile. A cargo area is defined between the cargo retaining ring and the base. The solid bulkhead includes a front surface that forms a rear end of the cargo area and a rear concave surface. A driving band seat can be added on the exterior surface of the body at the bulkhead, for each repeated launch of the projectile, as may be desired. A slipped obturator seat may be formed on the exterior surface of the base rearward of the driving band seat, as desired. |
| FILED | Monday, May 06, 2013 |
| APPL NO | 13/887605 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ammunition and explosives 12/502 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845206 | Chan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kenneth Y. Chan (Hopewell Junction, New York); Dennis Denizard (Poughkeepsie, New York); Michael J. Fisher (Poughkeepsie, New York); Gilles G. Labbe (Quebec, Canada); James E. Tersigni (Highland, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Kenneth Y. Chan (Hopewell Junction, New York); Dennis Denizard (Poughkeepsie, New York); Michael J. Fisher (Poughkeepsie, New York); Gilles G. Labbe (Quebec, Canada); James E. Tersigni (Highland, New York) |
| ABSTRACT | An apparatus is provided and includes a housing, a block formed to define an array of holes corresponding to an array of plugs into which connectors with spring loaded sleeves are pluggable such that the block engages with a respective sleeve of each connector, the block being supportively disposed within the housing to be movable with respect to the housing between first and second block positions at which the sleeves are extended and retracted, respectively and a cam lever supported on the housing and coupled to the block, which selectively occupies first and second lever positions at which the cam lever causes the block to assume the first and second block positions, respectively. |
| FILED | Tuesday, March 29, 2011 |
| APPL NO | 13/074748 |
| ART UNIT | 2883 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/3825 (20130101) G02B 6/3879 (20130101) Original (OR) Class G02B 6/3885 (20130101) G02B 6/3893 (20130101) G02B 6/3898 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845325 | Smith |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Matthew J. Smith (Springfield, Pennsylvania) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Matthew J. Smith (Springfield, Pennsylvania) |
| ABSTRACT | An apparatus for lighting an oxygen candle within a drum and for sealing the drum of an oxygen candle furnace. The apparatus includes a housing member for positioning the ignition assembly on a lid of the drum. The housing member having an upper portion, a lower portion and a borehole extending through the upper and lower portions. An ignition nail is placed in the borehole and housing member is structured to hold prevent the ignition nail from moving laterally, and to automatically align the nail with the oxygen candle within the drum. |
| FILED | Monday, October 24, 2011 |
| APPL NO | 13/280096 |
| ART UNIT | 3743 — Optics |
| CURRENT CPC | Combustion 431/267 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845754 | Streeter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alexander D. Streeter (Concord, New Hampshire); David E. Altobelli (Hollis, New Hampshire); N. Christopher Perry (Manchester, New Hampshire) |
| ASSIGNEE(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| INVENTOR(S) | Alexander D. Streeter (Concord, New Hampshire); David E. Altobelli (Hollis, New Hampshire); N. Christopher Perry (Manchester, New Hampshire) |
| ABSTRACT | A control unit system. The system includes a control unit which includes a control unit charging interface, at least one magnet located proximate to the control unit charging interface, at least one actuator, a detachable manifold including at least one magnet, fluidly coupled to the at least one actuator, a pump connected to the at least one actuator for causing actuation thereof, and a control system for controlling the pump, wherein the control system controls the pump to actuate the at least one actuator at least in response to a signal received by the control system. The system also includes a recharging device configured to receive the control unit, the recharging device including a reed switch, wherein when the magnet in the control unit is located proximate to the reed switch, the switch is activated. |
| FILED | Tuesday, May 01, 2012 |
| APPL NO | 13/461336 |
| ART UNIT | 3738 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/68 (20130101) A61F 2/7843 (20130101) A61F 5/012 (20130101) Original (OR) Class A61F 5/024 (20130101) A61F 5/34 (20130101) A61F 2002/704 (20130101) A61F 2002/741 (20130101) A61F 2002/745 (20130101) A61F 2002/5083 (20130101) A61F 2002/7635 (20130101) A61F 2002/7655 (20130101) A61F 2007/006 (20130101) A61F 2007/0063 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 39/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845866 | Yan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Min Yan (Ballston Lake, New York); Ahmet Gun Erlat (Clifton Park, New York); Jie Liu (Niskayuna, New York) |
| ASSIGNEE(S) | General Electric Company (Niskayuna, New York) |
| INVENTOR(S) | Min Yan (Ballston Lake, New York); Ahmet Gun Erlat (Clifton Park, New York); Jie Liu (Niskayuna, New York) |
| ABSTRACT | A method and system for DC magnetron sputtering deposition of films on plastic substrates. The method includes using a shield to block deposition in a spatial region corresponding to a plasma region formed during magnetron sputtering. An optoelectronic device including an amorphous electrode film is also disclosed. |
| FILED | Thursday, December 22, 2005 |
| APPL NO | 11/316267 |
| ART UNIT | 2879 — Optics |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/35 (20130101) C23C 14/044 (20130101) Original (OR) Class C23C 14/086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845873 | Poole et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | James E. Poole (Gibsonia, Pennsylvania); Richard F. Syput (Lower Burrell, Pennsylvania); Roy E. Dean (Natrona Heights, Pennsylvania); Michael J. Pawlik (Glenshaw, Pennsylvania); Edward E. Abbott (Canandaigua, New York); Joseph T. Valko (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | James E. Poole (Gibsonia, Pennsylvania); Richard F. Syput (Lower Burrell, Pennsylvania); Roy E. Dean (Natrona Heights, Pennsylvania); Michael J. Pawlik (Glenshaw, Pennsylvania); Edward E. Abbott (Canandaigua, New York); Joseph T. Valko (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are electrodepositable coating compositions comprising a film forming resin and a textured additive, wherein the textured additive has a density (specific gravity) of no more than 4.5 g/cc and a melting point greater than the curing temperature of the electrodepositable coating composition. Also described are coated substrates having a cured coating layer comprising the electrodepositable coating composition, wherein the cured film layer has a texture of at least 250μ-in as measured by a profilometer at conventional cured film thicknesses. |
| FILED | Friday, September 30, 2011 |
| APPL NO | 13/249772 |
| ART UNIT | 1781 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/4476 (20130101) Original (OR) Class Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/04 (20130101) C25D 13/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845879 | Minteer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Shelley Minteer (St. Louis, Missouri); Abdul Waheed (Valley Park, Missouri) |
| ASSIGNEE(S) | Saint Louis Univesrity (Saint Louis, Missouri) |
| INVENTOR(S) | Shelley Minteer (St. Louis, Missouri); Abdul Waheed (Valley Park, Missouri) |
| ABSTRACT | A method for monitoring the metabolic state of an organelle in the presence of a potential organelle modulating agent is disclosed. A first organelle-modified bioelectrode is provided that is electrically coupled to a second electrode of opposite polarity in a circuit. The first bioelectrode is contacted with an aqueous carrier containing a biologically acceptable electrolyte and an effective amount of a potential organelle modulating agent and an effective amount of an organelle substrate. The substrate is reacted at the bioelectrode to form an ionic product that is released into the aqueous carrier-containing electrolyte to thereby provide a current at the second electrode when the circuit is closed. A metabolic flux data set is obtained during the reaction and is compared to a control metabolic flux data set obtained under the same conditions in the absence of the organelle modulating agent, thereby determining the metabolic state of the organelle. |
| FILED | Monday, November 21, 2011 |
| APPL NO | 13/301773 |
| ART UNIT | 1759 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5076 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845898 | DeDe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brian C. DeDe (San Diego, California); Michael J. Rollins (Chula Vista, California); Melissa A. Bell (San Diego, California); David Lau (San Diego, California) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Windsor Locks, Connecticut) |
| INVENTOR(S) | Brian C. DeDe (San Diego, California); Michael J. Rollins (Chula Vista, California); Melissa A. Bell (San Diego, California); David Lau (San Diego, California) |
| ABSTRACT | An auxiliary power unit includes a gearbox housing portion and a filter housing portion providing an integral housing. A filter cavity is provided in the filter housing portion. A surface circumscribes the filter cavity. A scupper includes a passage extending from the surface to an opening on an exterior surface of the integral housing. A sealing region between the scupper and the filter cavity is configured to fluidly isolate the scupper and the fuel filter cavity from one another. In one example, the filter cavity receives a fuel filter cartridge. A cap is secured to the filter housing portion and encloses the filter cavity when in a secured position. |
| FILED | Wednesday, July 07, 2010 |
| APPL NO | 12/831491 |
| ART UNIT | 1778 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/04 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 41/00 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/32 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846058 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael J. Smith (Silver Spring, Maryland); Alison D. O'Brien (Bethesda, Maryland); Louise D. Teel (Silver Spring, Maryland); Angela R. Melton-Celsa (Sterling, Virginia) |
| ASSIGNEE(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Michael J. Smith (Silver Spring, Maryland); Alison D. O'Brien (Bethesda, Maryland); Louise D. Teel (Silver Spring, Maryland); Angela R. Melton-Celsa (Sterling, Virginia) |
| ABSTRACT | A chimeric Shiga toxoid according to the invention contains an enzymatically-inactivated StxA subunit and a native StxB subunit. This hybrid Shiga toxoid induces the production of broadly cross-reactive species of antibodies against Shiga toxin following immunization. The StxA subunit is modified so that it is enzymatically inactive. The invention thus encompasses the Shiga toxoid or fragments thereof and the nucleic acid sequence of the Shiga toxoid or fragments thereof. The invention further encompasses the production of a Shiga toxoid, the production of antibodies using the Shiga toxoid and methods of productions, and an immunogenic composition containing the Shiga toxoid. |
| FILED | Friday, February 16, 2007 |
| APPL NO | 12/279423 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/0258 (20130101) A61K 2039/55566 (20130101) Peptides C07K 14/245 (20130101) C07K 2319/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846081 | Reshetnyak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yana K. Reshetnyak (South Kingstown, Rhode Island); Oleg A. Andreev (South Kingstown, Rhode Island); Donald M. Engelman (New Haven, Connecticut) |
| ASSIGNEE(S) | Rhode Island Board of Governors for Higher Education (Kingston, Rhode Island); Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Yana K. Reshetnyak (South Kingstown, Rhode Island); Oleg A. Andreev (South Kingstown, Rhode Island); Donald M. Engelman (New Haven, Connecticut) |
| ABSTRACT | The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide. |
| FILED | Friday, August 12, 2011 |
| APPL NO | 13/208902 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/450 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846134 | Fetzer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christopher M. Fetzer (Santa Clarita, California); James H. Ermer (Burbank, California); Richard R. King (Thousand Oaks, California); Peter C. Colter (Canyon Country, California) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Christopher M. Fetzer (Santa Clarita, California); James H. Ermer (Burbank, California); Richard R. King (Thousand Oaks, California); Peter C. Colter (Canyon Country, California) |
| ABSTRACT | A method of disordering a layer of an optoelectronic device including; growing a plurality of lower layers; introducing an isoelectronic surfactant; growing a layer; allowing the surfactant to desorb; and growing subsequent layers all performed at a low pressure of 25 torr. |
| FILED | Thursday, September 07, 2006 |
| APPL NO | 11/517156 |
| ART UNIT | 1712 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0245 (20130101) H01L 21/02381 (20130101) H01L 21/02458 (20130101) H01L 21/02463 (20130101) H01L 21/02502 (20130101) H01L 21/02521 (20130101) H01L 21/02543 (20130101) H01L 21/02658 (20130101) H01L 31/184 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/544 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846189 | Vaidya et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Uday Vaidya (Birmingham, Alabama); J. Barry Andrews (Birmingham, Alabama); Selvum Pillay (Birmingham, Alabama); Haibin Ning (Birmingham, Alabama) |
| ASSIGNEE(S) | UAB Research Foundation (Birmingham, Alabama) |
| INVENTOR(S) | Uday Vaidya (Birmingham, Alabama); J. Barry Andrews (Birmingham, Alabama); Selvum Pillay (Birmingham, Alabama); Haibin Ning (Birmingham, Alabama) |
| ABSTRACT | Aeroshells and methods for manufacturing aeroshells are provided. In this regard, a representative aeroshell for a missile formed of a long fiber thermoplastic composite exhibits a wall thickness of no greater than approximately 0.070″. |
| FILED | Friday, April 16, 2010 |
| APPL NO | 12/761821 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Stock material or miscellaneous articles 428/292.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846190 | Belcher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Board of Regents, The University of Texas System (Austin, Texas); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Angela M. Belcher (Lexington, Massachusetts); Chuanbin Mao (Austin, Texas); Daniel J. Solis (Austin, Texas) |
| ABSTRACT | Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the organic scaffold along a length of the organic scaffold; and fusing the nanoparticles attached to the organic scaffold to form an inorganic nanowire. |
| FILED | Tuesday, August 27, 2013 |
| APPL NO | 14/010962 |
| ART UNIT | 1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/01 (20130101) H01B 1/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846329 | Pfleger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Brian Frederick Pfleger (Madison, Wisconsin); Matthew Brett Begemann (Madison, Wisconsin) |
| ABSTRACT | Organic acid-producing microorganisms and methods of using same. The organic acid-producing microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid, acrylic acid, propionic acid, lactic acid, and others. Further modifications to the microorganisms increase production of such organic acids as 3-hydroxypropionic acid, lactate, and others. Methods of producing such organic acids as 3-hydroxypropionic acid, lactate, and others with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers are also provided. |
| FILED | Friday, March 07, 2014 |
| APPL NO | 14/200686 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846330 | Bina et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Saiid Bina (Gaithersburg, Maryland); Rolf Bunger (McLean, Virginia) |
| ASSIGNEE(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Saiid Bina (Gaithersburg, Maryland); Rolf Bunger (McLean, Virginia) |
| ABSTRACT | The present invention encompasses methods for diagnosis of calcium channel related diseases (e.g., RyR1-related diseases) comprising contacting lymphocytes isolated from a subject with a calcium channel agonist (e.g., an RyR1 agonist), measuring the adenosine and inosine produced by the lymphocytes; and comparing the measured levels in the sample to the adenosine and inosine levels in a normal control, whereby an increase in the adenosine and inosine levels relative to the control is indicative of a calcium channel related disease (e.g., RyR1-related disease). The invention also encompasses kits for diagnosis of calcium channel-related diseases. |
| FILED | Tuesday, September 08, 2009 |
| APPL NO | 13/062654 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/6872 (20130101) Original (OR) Class G01N 2800/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846354 | Pfleger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Brian Frederick Pfleger (Madison, Wisconsin); Matthew Brett Begemann (Madison, Wisconsin) |
| ABSTRACT | Organic acid-producing microorganisms and methods of using same. The organic acid-producing microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid, acrylic acid, propionic acid, lactic acid, and others. Further modifications to the microorganisms increase production of such organic acids as 3-hydroxypropionic acid, lactate, and others. Methods of producing such organic acids as 3-hydroxypropionic acid, lactate, and others with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers are also provided. |
| FILED | Friday, March 07, 2014 |
| APPL NO | 14/200747 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846404 | Odom et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Susan A. Odom (Champaign, Illinois); Mary M. Caruso (Urbana, Illinois); Aaron D. Finke (Urbana, Illinois); Aaron C. Jackson (Urbana, Illinois); Jeffrey S. Moore (Savoy, Illinois); Nancy R. Sottos (Champaign, Illinois); Scott R. White (Champaign, Illinois) |
| ASSIGNEE(S) | Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Susan A. Odom (Champaign, Illinois); Mary M. Caruso (Urbana, Illinois); Aaron D. Finke (Urbana, Illinois); Aaron C. Jackson (Urbana, Illinois); Jeffrey S. Moore (Savoy, Illinois); Nancy R. Sottos (Champaign, Illinois); Scott R. White (Champaign, Illinois) |
| ABSTRACT | A self-indicating material system may include a solid polymer matrix having a first color, a first plurality of capsules in the matrix, and a plurality of particles in the matrix. The first plurality of capsules includes a first reactant, and the plurality of particles includes a second reactant, which forms a product when in contact with the first reactant. When a crack forms in the polymer matrix, at least a portion of the first plurality of capsules is ruptured, the first and second reactants form the product in the matrix, and the portion of the polymer matrix containing the product has a second color different from the first color. A self-indicating material system may include a solid polymer matrix, a plurality of capsules in the matrix, and an activator in the matrix, where the polymer matrix includes a first polymer and has a first color, the plurality of capsules includes a polymerizer, and the activator is an activator for the polymerizer. When a crack forms in the polymer matrix, at least a portion of the plurality of capsules is ruptured, the polymerizer and the activator form a second polymer in the crack, and the second polymer has a second color different from the first color. |
| FILED | Friday, June 24, 2011 |
| APPL NO | 13/168166 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846586 | Sawyer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wallace Gregory Sawyer (Gainesville, Florida); Jennifer Vail (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| INVENTOR(S) | Wallace Gregory Sawyer (Gainesville, Florida); Jennifer Vail (Gainesville, Florida) |
| ABSTRACT | Briefly described, embodiments of this disclosure include articles and methods of making articles. |
| FILED | Wednesday, May 12, 2010 |
| APPL NO | 13/319274 |
| ART UNIT | 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 107/32 (20130101) C10M 107/38 (20130101) Original (OR) Class C10M 109/00 (20130101) C10M 2211/063 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2220/08 (20130101) C10N 2220/086 (20130101) C10N 2230/06 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846653 | Malafa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | Mokenge P. Malafa (Tampa, Florida); Said M. Sebti (Tampa, Florida) |
| ABSTRACT | Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds are shown both in vitro and in vivo using several human pancreatic cancer cell lines and MIA-PACA2 human pancreatic cancer cells xenografted in nude mice. Also disclosed are methods of testing the efficacy of potential chemotherapeutic agents by measuring their effect on surrogate endpoint biomarkers, such as Ki-67 and p27. Associated compounds are also disclosed. |
| FILED | Tuesday, October 16, 2012 |
| APPL NO | 13/653108 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/183 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846693 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Peng Li (New York, New York); Jun Zhao (New York, New York); Hailin Zheng (New York, New York) |
| ASSIGNEE(S) | Intra-Cellular Therapies, Inc. (New York, New York) |
| INVENTOR(S) | Peng Li (New York, New York); Jun Zhao (New York, New York); Hailin Zheng (New York, New York) |
| ABSTRACT | 1- or 2- or 7-(substituted)-3-(optionally hetero)arylamino-[1H,2H]-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives, in free, salt or prodrug form, are useful as pharmaceuticals, particularly as phosphodiesterase 1 inhibitors, useful for the treatment of diseases involving disorders of the dopamine D1 receptor intracellular pathway, such as Parkinson's disease, depression, narcolepsy and damage to cognitive function, e.g., in schizophrenia or disorders that may be ameliorated through enhanced progesterone-signaling pathway, e.g., female sexual dysfunction. |
| FILED | Saturday, December 06, 2008 |
| APPL NO | 12/746231 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847074 | Mann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jennifer Mann (Chichester, New Hampshire); David S. Lashmore (Lebanon, New Hampshire); Brian White (Manchester, New Hampshire); Peter L. Antoinette (Nashua, New Hampshire) |
| ASSIGNEE(S) | Nanocomp Technologies (Merrimack, New Hampshire) |
| INVENTOR(S) | Jennifer Mann (Chichester, New Hampshire); David S. Lashmore (Lebanon, New Hampshire); Brian White (Manchester, New Hampshire); Peter L. Antoinette (Nashua, New Hampshire) |
| ABSTRACT | A cable having a conducting member made from a nanostructure-based material, and a shielding layer made of nanostructure-based material. The shielding layer can be circumferentially situated about the conducting member so as to enhance conductivity along the conducting member. A coupling mechanism may be situated between the shielding layer and the conducting member so as to secure the shielding layer in its position on the conducting member. A method of making the cable is also disclosed. |
| FILED | Thursday, May 07, 2009 |
| APPL NO | 12/437537 |
| ART UNIT | 2847 — Electrical Circuits and Systems |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) Original (OR) Class H01B 13/0162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847490 | Dayton, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | James A. Dayton, Jr. (Cleveland, Ohio); Carol L. Kory (Westlake, Ohio) |
| ASSIGNEE(S) | Manhattan Technologies Ltd. (Richmond Heights, Ohio) |
| INVENTOR(S) | James A. Dayton, Jr. (Cleveland, Ohio); Carol L. Kory (Westlake, Ohio) |
| ABSTRACT | Disclosed herein is a class of mm and sub mm wavelength amplifiers and oscillators operating with miniature helical slow wave circuits manufactured using micro fabrication technology. The helices are supported by diamond dielectric support rods. Diamond is the best possible thermal conductor, and it can be bonded to the helix. The electron beam is transmitted, not through the center of the helix, but around the outside. In some configurations the RF power produced may be radiated directly from the slow wave circuit. The method of fabrication, which is applicable above 60 GHz, is compatible with mass production. |
| FILED | Thursday, March 22, 2012 |
| APPL NO | 13/427226 |
| ART UNIT | 2821 — Semiconductors/Memory |
| CURRENT CPC | Electric lamp and discharge devices: Systems 315/39.300 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847563 | Callanan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert Joseph Callanan (Raleigh, North Carolina) |
| ASSIGNEE(S) | Cree, Inc. (Durham, North Carolina) |
| INVENTOR(S) | Robert Joseph Callanan (Raleigh, North Carolina) |
| ABSTRACT | A power converter circuit includes a storage component, a rectifier component comprising a first field effect transistor and having first and second bias states, and a switch including a second field effect transistor having first and second operational states. The first and second field effect transistors are High Electron Mobility Transistors (HEMTs). |
| FILED | Thursday, July 15, 2010 |
| APPL NO | 12/837092 |
| ART UNIT | 2838 — Electrical Circuits and Systems |
| CURRENT CPC | Pulse Technique H03K 17/74 (20130101) H03K 17/567 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847611 | Ulmen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | John V Ulmen (Redwood City, California); Barrett E. Heyneman (Redwood City, California) |
| ABSTRACT | A rotary position sensor is provided that includes a sensing disc having an N-fold rotation symmetry and capacitive sensing pads arranged in an array pattern, where the array pattern has at least 4N-fold rotation symmetry, where N≧2, a scale disc disposed opposite the sensing disc, where the scale disc includes a pattern of conductive pads that have a sinusoidal-shape, where the pattern of sinusoidal-shaped conductive pads produce four sinusoidal capacitance waveforms in quadrature phase with the capacitive sensing pads as the sensing disc and the scale disc are rotated relative to one another to provide angular position information. to provide angular position information. This is achieved by making the overlapping area of the of the capacitive sensing pads change in a sinusoidal fashion with rotation. |
| FILED | Thursday, September 27, 2012 |
| APPL NO | 13/628629 |
| ART UNIT | 2866 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/2415 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847637 | Guyton |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Matthew C. Guyton (Arlington, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Matthew C. Guyton (Arlington, Massachusetts) |
| ABSTRACT | Described are a multi-modulus frequency divider and event counter that are based on time-interleaved signals generated from a received signal. For the frequency divider, each time-interleaved clock signal generated from a received clock signal is provided to a bit counter and the output signal from each bit counter is provided to a multiplexer. A multiplexer selection module controls over time which one of the output signals from the bit counters is presented at the output of the multiplexer. The transition frequency of the bits in the time-interleaved clock signals allows various circuit components such as the bit counters to be implemented as CMOS components. Thus the frequency divider is more power-efficient than conventional frequency divider circuits operating at high clock frequencies. |
| FILED | Thursday, May 24, 2012 |
| APPL NO | 13/479471 |
| ART UNIT | 2842 — Electrical Circuits and Systems |
| CURRENT CPC | Pulse Technique H03K 23/58 (20130101) Original (OR) Class H03K 23/667 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847965 | Chandak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Anish Chandak (Carrboro, North Carolina); Lakulish Shailesh Antani (Chapel Hill, North Carolina); Micah Taylor (Pittsboro, North Carolina); Dinesh Manocha (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Anish Chandak (Carrboro, North Carolina); Lakulish Shailesh Antani (Chapel Hill, North Carolina); Micah Taylor (Pittsboro, North Carolina); Dinesh Manocha (Chapel Hill, North Carolina) |
| ABSTRACT | Methods, systems, and computer program products for simulating sound propagation can be operable to define a sound source position within a modeled scene having a given geometry and construct a visibility tree for modeling sound propagation paths within the scene. Using from-region visibility techniques to model sound diffraction and from-point visibility technique to model specular sound reflections within the scene, the size of the visibility tree can be reduced. Using the visibility tree, an impulse response can be generated for the scene, and the impulse response can be used to simulate sound propagation in the scene. |
| FILED | Monday, December 05, 2011 |
| APPL NO | 13/373901 |
| ART UNIT | 2617 — Electrical Circuits and Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 17/5009 (20130101) Image Data Processing or Generation, in General G06T 13/00 (20130101) Original (OR) Class G06T 13/40 (20130101) G06T 15/40 (20130101) Stereophonic Systems H04S 2400/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848006 | Wetzstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gordon Wetzstein (Cambridge, Massachusetts); Douglas Lanman (Somerville, Massachusetts); Matthew Hirsch (Somerville, Massachusetts); Ramesh Raskar (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Gordon Wetzstein (Cambridge, Massachusetts); Douglas Lanman (Somerville, Massachusetts); Matthew Hirsch (Somerville, Massachusetts); Ramesh Raskar (Cambridge, Massachusetts) |
| ABSTRACT | In exemplary implementations of this invention, an automultiscopic display device includes (1) one or more spatially addressable, light attenuating layers, and (2) a controller which is configured to perform calculations to control the device. In these calculations, tensors provide sparse, memory-efficient representations of a light field. The calculations include using weighted nonnegative tensor factorization (NTF) to solve an optimization problem. The NTF calculations can be sufficiently efficient to achieve interactive refresh rates. Either a directional backlight or a uniform backlight may be used. For example, the device may have (1) a high resolution LCD in front, and (2) a low resolution directional backlight. Or, for example, the device may have a uniform backlight and three or more LCD panels. In these examples, all of the LCDs and the directional backlight (if applicable) may be time-multiplexed. |
| FILED | Tuesday, January 08, 2013 |
| APPL NO | 13/736769 |
| ART UNIT | 2692 — Selective Visual Display Systems |
| CURRENT CPC | Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/3406 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848046 | Stofko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pavol Stofko (Milford, Pennsylvania); Pasquale Carlucci (Fair Lawn, New Jersey); Mark Mellini (Denville, New Jersey) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Pavol Stofko (Milford, Pennsylvania); Pasquale Carlucci (Fair Lawn, New Jersey); Mark Mellini (Denville, New Jersey) |
| ABSTRACT | A round for launching from a gun may include a cartridge case and a projectile body adjacent the cartridge case. A pusher may be disposed in the cartridge case and may be operable to push the projectile body upon firing the round. An imaging sensor may be disposed at least partially in the projectile body. The imaging sensor may include a sensor base and a sensor lens. A first kinetic energy absorber may be disposed around the sensor base. A second kinetic energy absorber may be disposed around the sensor lens. After the round is fired and the pusher exits the gun, the pusher may separate from the projectile body and the second kinetic energy absorber may separate from the imaging sensor. |
| FILED | Thursday, August 25, 2011 |
| APPL NO | 13/217690 |
| ART UNIT | 2487 — Recording and Compression |
| CURRENT CPC | Television 348/61 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848091 | Baraniuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Richard g. Baraniuk (Houston, Texas); Dror Z. Baron (Cary, North Carolina); Marco F. Duarte (Durham, North Carolina); Kevin F. Kelly (Houston, Texas); Courtney C. Lane (Ventura, California); Jason N. Laska (Houston, Texas); Dharmpal Takhar (Houston, Texas); Michael B. Wakin (Castle Rock, Colorado) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Richard g. Baraniuk (Houston, Texas); Dror Z. Baron (Cary, North Carolina); Marco F. Duarte (Durham, North Carolina); Kevin F. Kelly (Houston, Texas); Courtney C. Lane (Ventura, California); Jason N. Laska (Houston, Texas); Dharmpal Takhar (Houston, Texas); Michael B. Wakin (Castle Rock, Colorado) |
| ABSTRACT | A new digital image/video camera that directly acquires random projections of the incident light field without first collecting the pixels/voxels. In one preferred embodiment, the camera employs a digital micromirror array to perform optical calculations of linear projections of an image onto pseudorandom binary patterns. Its hallmarks include the ability to obtain an image with only a single detection element while measuring the image/video fewer times than the number of pixels or voxels—this can significantly reduce the computation required for image/video acquisition/encoding. Since the system features a single photon detector, it can also be adapted to image at wavelengths that are currently impossible with conventional CCD and CMOS imagers. |
| FILED | Wednesday, May 02, 2012 |
| APPL NO | 13/462212 |
| ART UNIT | 2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 25/20 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 3/08 (20130101) H04N 5/335 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848183 | Yi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wei Yi (Mountain View, California); Fung Suong Ou (Palo Alto, California); Min Hu (Sunnyvale, California); Wei Wu (Palo Alto, California); Zhiyong Li (Foster City, California) |
| ASSIGNEE(S) | Hewlett-Packard Development Company, L.P. (Houston, Texas) |
| INVENTOR(S) | Wei Yi (Mountain View, California); Fung Suong Ou (Palo Alto, California); Min Hu (Sunnyvale, California); Wei Wu (Palo Alto, California); Zhiyong Li (Foster City, California) |
| ABSTRACT | An apparatus includes a substrate and a plurality of nano-fingers attached at respective first ends to the substrate and freely movable along their lengths, in which a first set of the plurality of nano-fingers comprises a first physical characteristic, wherein a second set of the plurality of nano-fingers comprises a second physical characteristic, and wherein the first physical characteristic differs from the second physical characteristic. |
| FILED | Friday, July 22, 2011 |
| APPL NO | 13/188941 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) B82Y 20/00 (20130101) B82Y 40/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848197 | Pruessner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marcel W. Pruessner (Silver Spring, Maryland); Todd H. Stievater (Arlington, Virginia); William S. Rabinovich (Silver Spring, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Marcel W. Pruessner (Silver Spring, Maryland); Todd H. Stievater (Arlington, Virginia); William S. Rabinovich (Silver Spring, Maryland) |
| ABSTRACT | A mass sensor system including multiple Fabry-Perot microcavities connected in parallel by multiple waveguides. Each of the mass sensors includes a microbridge having a fundamental resonance frequency, and a movable reflective mirror etched into the microbridge; a fixed reflective mirror etched in a substrate, the fixed reflective mirror being fixed to the substrate in a region spaced apart from the movable reflective mirror; and an optical waveguide etched in the substrate that connects the movable mirror and the fixed mirror forming the Fabry-Perot microcavity interferometer. The system includes a tunable continuous-wave laser operative to optically interrogate the Fabry-Perot microcavity of each of the plurality of mass sensors, and a receiver operative to receive sensor signals from each of the plurality of mass sensors, the sensor signals comprising reflective signals and transmitted signals. A continuous-wave laser may generate optical forces that modify the motion, dynamics, or mechanical Q-factor of the microbridge. |
| FILED | Thursday, July 18, 2013 |
| APPL NO | 13/945075 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02004 (20130101) G01B 9/02051 (20130101) G01B 2290/25 (20130101) Weighing G01G 3/165 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/17 (20130101) Original (OR) Class G01N 29/036 (20130101) G01N 2291/0256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848754 | Botez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dan Botez (Madison, Wisconsin); Jae Cheol Shin (Gwangsan-gu, South Korea) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Dan Botez (Madison, Wisconsin); Jae Cheol Shin (Gwangsan-gu, South Korea) |
| ABSTRACT | Semiconductor structures for laser devices are provided. The semiconductor structures have a quantum cascade laser structure comprising an electron injector, an active region, and an electron extractor. The active region comprises an injection barrier, a multiquantum well structure, and an exit barrier. The multiquantum well structure can comprise a first barrier, a first quantum well, a second barrier, a second quantum well, and a third barrier. The energies of the first and second barrier are less than the energy of the third barrier. The energy difference between the energy of the second barrier and the energy of the third barrier can be greater than 150 meV and the ratio of the energy of the third barrier to the energy of the second barrier can be greater than 1.26. |
| FILED | Wednesday, August 22, 2012 |
| APPL NO | 13/591645 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/00 (20130101) H01S 5/20 (20130101) H01S 5/34 (20130101) H01S 5/2009 (20130101) H01S 5/2013 (20130101) H01S 5/3216 (20130101) H01S 5/3401 (20130101) Original (OR) Class H01S 5/3407 (20130101) H01S 5/3412 (20130101) H01S 5/3413 (20130101) H01S 5/3418 (20130101) H01S 5/3425 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848760 | Vahala et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Kerry Vahala (Pasadena, California); Tong Chen (Pasadena, California); Hansuek Lee (Pasadena, California); Myoung-Gyun Suh (Pasadena, California) |
| ABSTRACT | An optical apparatus comprises a waveguide substrate and an optical reference cavity. The optical reference cavity comprises an optical waveguide formed on the waveguide substrate and arranged to form a closed loop greater than or about equal to 10 cm in length. The RMS resonance frequency fluctuation is less than or about equal to 100 Hz. The Q-factor can be greater than or about equal to 108. The optical waveguide can exhibit optical loss less than or about equal to 0.2 dB/m for propagation of an optical signal along the optical waveguide. The closed loop path can comprise two or more linked spirals greater than or about equal to 1 meter in length and can occupy an area on the waveguide substrate less than or about equal to 5 cm2. |
| FILED | Friday, March 15, 2013 |
| APPL NO | 13/831692 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Coherent light generators 372/92 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848904 | Baras et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John S. Baras (Potomac, Maryland); Paul L. Yu (Silver Spring, Maryland); Brian M. Sadler (Laurel, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); The United States of America as represented by Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | John S. Baras (Potomac, Maryland); Paul L. Yu (Silver Spring, Maryland); Brian M. Sadler (Laurel, Maryland) |
| ABSTRACT | The replacement of secret keys is a central problem in key management. Typical solutions exchange handshaking messages, involve complex computations, or require the cooperation of trusted third parties. Disclosed herein is a key replacement method that exploits the randomness of Markov models to efficiently provide fresh keys to users. Unlike other methods, the proposed method removes the need for extra communications, intensive computation, or third parties. It is demonstrated that the proposed method has perfect forward secrecy as well as resistance to known-key attacks. |
| FILED | Friday, October 23, 2009 |
| APPL NO | 12/605167 |
| ART UNIT | 2453 — Computer Networks |
| CURRENT CPC | Secret Communication; Jamming of Communication H04K 1/10 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/08 (20130101) Pictorial Communication, e.g Television H04N 21/26613 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849072 | Montoya et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Juan Montoya (Cambridge, Massachusetts); Mark G. Allen (Boston, Massachusetts); Joel M. Hensley (Chelmsford, Massachusetts); Krishnan R. Parameswaran (Tewksbury, Massachusetts); Rajeev Ram (Arlington, Massachusetts) |
| ASSIGNEE(S) | Physical Sciences, Inc. (Andover, Massachusetts) |
| INVENTOR(S) | Juan Montoya (Cambridge, Massachusetts); Mark G. Allen (Boston, Massachusetts); Joel M. Hensley (Chelmsford, Massachusetts); Krishnan R. Parameswaran (Tewksbury, Massachusetts); Rajeev Ram (Arlington, Massachusetts) |
| ABSTRACT | An optical device for integrated photonic applications includes a substrate, a dielectric waveguide and a surface plasmon waveguide. The dielectric waveguide includes a dielectric waveguide core disposed relative to a dielectric waveguide cladding and a common cladding. The surface plasmon waveguide includes a surface plasmon waveguide core disposed relative to the common cladding and a surface plasmon waveguide cladding. The common cladding couples the dielectric waveguide and the surface plasmon waveguide. |
| FILED | Thursday, February 11, 2010 |
| APPL NO | 12/704174 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 6/1226 (20130101) Original (OR) Class G02B 2006/12097 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/011 (20130101) G02F 1/0955 (20130101) G02F 2203/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849075 | Painter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Oskar Painter (Sierra Madre, California); Martin Winger (Pasadena, California); Qiang Lin (Rochester, New York); Amir Safavi-Naeini (Pasadena, California); Thiago Alegre (Campinas, Brazil); Timothy Dobson Blasius (Pasadena, California); Alexander Grey Krause (Pasadena, California) |
| ABSTRACT | The present disclosure describes an integrated opto-mechanical and electro-mechanical system. The opto-mechanical and electro-mechanical system can be made of photonic crystals configured to move based on electrical voltages and/or back action effects from electromagnetic waves, thus changing the resonance of the system. |
| FILED | Friday, November 09, 2012 |
| APPL NO | 13/673916 |
| ART UNIT | 2883 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/1225 (20130101) Original (OR) Class G02B 26/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849080 | Manzur |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tariq Manzur (Lincoln, Rhode Island) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Tariq Manzur (Lincoln, Rhode Island) |
| ABSTRACT | An optical fiber coupler includes a clad optical fiber core having a coupling window formed therein. A laser source is joined to emit light into the core through the coupling window. The core has an output coupler for partially reflecting a portion of light and transmitting a portion as output. A Bragg grating is formed in the core having a pitch and being positioned to reflect light from said laser source toward the output coupler. The pitch is variable in response to a temperature change. A thermal control device is joined to the core for adjusting its temperature and the Bragg grating pitch. In other embodiments a mode convertor is provided to reduce the output modes to selected modes. |
| FILED | Monday, January 14, 2013 |
| APPL NO | 13/740346 |
| ART UNIT | 2883 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/34 (20130101) Original (OR) Class G02B 6/02095 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/067 (20130101) H01S 3/0675 (20130101) H01S 3/06708 (20130101) H01S 3/094003 (20130101) H01S 3/094019 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849083 | Samson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bryce N. Samson (Granby, Connecticut); Kanxian Wei (Shrewsbury, Massachusetts); Liang Dong (Clemson, South Carolina) |
| ASSIGNEE(S) | Nufern (East Granby, Connecticut) |
| INVENTOR(S) | Bryce N. Samson (Granby, Connecticut); Kanxian Wei (Shrewsbury, Massachusetts); Liang Dong (Clemson, South Carolina) |
| ABSTRACT | The present invention relates generally to optical waveguides, and more particularly to optical fibers suitable for use with high optical energies, and to devices using them. One aspect of the invention is an optical fiber having a cross-sectional profile comprising a base glass material; a first ring of first low refractive index glass features disposed in the base glass material; and a second ring of second low refractive index glass features disposed in the base glass material outside of and substantially concentric with the first ring, wherein the optical fiber has a loss of less than about 0.7 dB/m for the fundamental mode and a loss greater than about 10 dB/m for all other modes in a coiled configuration having a coil diameter in the range of about 20 cm to about 200 cm. |
| FILED | Friday, April 27, 2012 |
| APPL NO | 13/458945 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/02333 (20130101) G02B 6/02347 (20130101) G02B 6/02357 (20130101) Original (OR) Class G02B 6/02361 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849124 | Guha |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Saikat Guha (Everett, Massachusetts) |
| ASSIGNEE(S) | Raytheon BBN Technologies, Corp. (Cambridge, Massachusetts) |
| INVENTOR(S) | Saikat Guha (Everett, Massachusetts) |
| ABSTRACT | An optical imaging system includes a transmitter configured to generate spatially entangled quantum states of light to probe reflective targets, a target configured to reflect the spatially entangled quantum states of light and a receiver configured to receive and detect the spatially entangled quantum states of light, thereby decoding a message encoded in a memory. |
| FILED | Friday, May 04, 2012 |
| APPL NO | 13/464253 |
| ART UNIT | 2636 — Optical Communications |
| CURRENT CPC | Optical communications 398/140 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849189 | Burmeister et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aaron Burmeister (San Diego, California); Narek Pezeshkian (San Diego, California); Hoa G. Nguyen (San Diego, California) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Aaron Burmeister (San Diego, California); Narek Pezeshkian (San Diego, California); Hoa G. Nguyen (San Diego, California) |
| ABSTRACT | A relay apparatus comprising a housing having a bottom surface, a radio, and a processor, both mounted within the housing. A self-righting mechanism is mounted to the housing such that the self-righting mechanism is configured to reposition the housing from any initial position to an upright position so that the housing rests on the bottom surface. The radio is configured to relay RF signals and to operate as a node in an ad hoc telecommunications network. The processor is operatively coupled to the radio and the self-righting mechanism. |
| FILED | Wednesday, August 01, 2007 |
| APPL NO | 11/832065 |
| ART UNIT | 2649 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Telecommunications 455/11.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849483 | Kuwata et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yoshiaki Kuwata (Los Angeles, California); Michael T. Wolf (Los Angeles, California); Dimitri V. Zarzhitsky (La Canada Flintridge, California); Hrand Aghazarian (La Crescenta, California); Terrance L. Huntsberger (Altadena, California); Andrew B. Howard (Los Angeles, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Yoshiaki Kuwata (Los Angeles, California); Michael T. Wolf (Los Angeles, California); Dimitri V. Zarzhitsky (La Canada Flintridge, California); Hrand Aghazarian (La Crescenta, California); Terrance L. Huntsberger (Altadena, California); Andrew B. Howard (Los Angeles, California) |
| ABSTRACT | Systems and methods for operating autonomous waterborne vessels in a safe manner. The systems include hardware for identifying the locations and motions of other vessels, as well as the locations of stationary objects that represent navigation hazards. By applying a computational method that uses a maritime navigation algorithm for avoiding hazards and obeying COLREGS using Velocity Obstacles to the data obtained, the autonomous vessel computes a safe and effective path to be followed in order to accomplish a desired navigational end result, while operating in a manner so as to avoid hazards and to maintain compliance with standard navigational procedures defined by international agreement. The systems and methods have been successfully demonstrated on water with radar and stereo cameras as the perception sensors, and integrated with a higher level planner for trailing a maneuvering target. |
| FILED | Friday, April 13, 2012 |
| APPL NO | 13/446899 |
| ART UNIT | 3668 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 1/00 (20130101) G05D 1/02 (20130101) G05D 1/0206 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849646 | Cutts et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Norwich University Applied Research Institutes (Northfield, Vermont) |
| ASSIGNEE(S) | Norwich University Applied Research Institutes (Northfield, Vermont) |
| INVENTOR(S) | Andrew W. Cutts (Henniker, New Hampshire); Robert Schmidt (Princeton, New Jersey) |
| ABSTRACT | Methods and apparatus for simulating a distributed business process are disclosed. The methods and apparatus simulate an interdependent business process, such as a financial transaction system, in a secure distributed manner. Each business entity that is part of the interdependent business process models itself on a local client device at any chosen level of detail. A simulation server connects the separate client based simulations into one large simulation. Details of each local simulation may be hidden from other simulation participants. However, interruptions in business flow caused by simulated disruptions introduced at the simulation server and/or a client device are propagated to all of the effected simulation participants via the simulation server. In addition, if a client based model is not available, the server supplies a software agent to replace the inputs and outputs normally associated with that portion of the overall simulation. |
| FILED | Thursday, January 31, 2013 |
| APPL NO | 13/755670 |
| ART UNIT | 3661 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 9/455 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 40/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08850290 | Guthridge |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | D. Scott Guthridge (San Jose, California) |
| ABSTRACT | Embodiments of the invention relate to calculation of error rate for data storage which includes determining a completion status of a read operation of data stored in a storage device, the completion status being one of at least partially complete or not complete. The fault monitoring count is incremented based on the completion status being not complete. The fault monitoring count is decreased based on the completion status being at least partially complete. The fault monitoring count being decreased according to a value based on the number of bytes successfully read. The error rate indicator value is being calculated based on an exponential decay rate related to the number of bytes read. The fault monitoring count threshold is monitored every time the fault monitoring count is incremented and the storage device is identified as faulty once the threshold limit is exceeded. |
| FILED | Friday, November 09, 2012 |
| APPL NO | 13/673657 |
| ART UNIT | 2117 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 11/076 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 08844205 | Michael et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | The Penn State Research Foundation (University Park, Pennsylvania); Lehigh University (Bethlehem, Pennsylvania) |
| INVENTOR(S) | Robert J. Michael (Waterford, Pennsylvania); Shannon K. Sweeney (Erie, Pennsylvania); Ernest B. Ferro (Corry, Pennsylvania); Richard Sause, Jr. (Hellertown, Pennsylvania); James M. Ricles (Bethlehem, Pennsylvania); Akbar Mahvashmohammadi (Bethlehem, Pennsylvania); Jeffrey A. Ferro (Corry, Pennsylvania) |
| ABSTRACT | A passive damper for earthquake hazard reduction includes an inner member received in an outer member, with an elastomeric material disposed in the gaps between the inner and outer member. The elastomeric material has at least a first and a second portion. The first portion is bonded or connected to both the inner member and outer member such that no slippage occurs between the members and the material. The second portion is not bonded or connected to at least one of the inner and outer members such that slippage may occur. |
| FILED | Monday, January 07, 2013 |
| APPL NO | 13/735637 |
| ART UNIT | 3635 — Static Structures, Supports and Furniture |
| CURRENT CPC | General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 1/985 (20130101) Springs; Shock-absorbers; Means for Damping Vibration F16F 7/09 (20130101) F16F 9/303 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08844369 | Botvinick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Elliot Botvinick (Irvine, California); Samir Shreim (Irvine, California); Maxwell Kotlarchyk (Costa Mesa, California) |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Elliot Botvinick (Irvine, California); Samir Shreim (Irvine, California); Maxwell Kotlarchyk (Costa Mesa, California) |
| ABSTRACT | An apparatus and method for providing a gradient strain to an extracellular matrix to induce mechanotransduction. The gradient strain can be produced by adhering the extracellular matrix to a post and the walls of a sample holder, and then rotating the post and the sample holder. This strain can result in increased stiffness of the extracellular matrix with very little loss of pore size. |
| FILED | Thursday, April 26, 2012 |
| APPL NO | 13/457342 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3691 (20130101) Apparatus for Enzymology or Microbiology; C12M 35/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/24 (20130101) Original (OR) Class G01N 11/14 (20130101) G01N 2203/0089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845879 | Minteer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Shelley Minteer (St. Louis, Missouri); Abdul Waheed (Valley Park, Missouri) |
| ASSIGNEE(S) | Saint Louis Univesrity (Saint Louis, Missouri) |
| INVENTOR(S) | Shelley Minteer (St. Louis, Missouri); Abdul Waheed (Valley Park, Missouri) |
| ABSTRACT | A method for monitoring the metabolic state of an organelle in the presence of a potential organelle modulating agent is disclosed. A first organelle-modified bioelectrode is provided that is electrically coupled to a second electrode of opposite polarity in a circuit. The first bioelectrode is contacted with an aqueous carrier containing a biologically acceptable electrolyte and an effective amount of a potential organelle modulating agent and an effective amount of an organelle substrate. The substrate is reacted at the bioelectrode to form an ionic product that is released into the aqueous carrier-containing electrolyte to thereby provide a current at the second electrode when the circuit is closed. A metabolic flux data set is obtained during the reaction and is compared to a control metabolic flux data set obtained under the same conditions in the absence of the organelle modulating agent, thereby determining the metabolic state of the organelle. |
| FILED | Monday, November 21, 2011 |
| APPL NO | 13/301773 |
| ART UNIT | 1759 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5076 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846146 | Abelson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John R. Abelson (Urbana, Illinois); Gregory S. Girolami (Urbana, Illinois); Shaista Babar (Urbana, Illinois); Navneet Kumar (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | John R. Abelson (Urbana, Illinois); Gregory S. Girolami (Urbana, Illinois); Shaista Babar (Urbana, Illinois); Navneet Kumar (Urbana, Illinois) |
| ABSTRACT | The present invention provides methods for making structures, including nanosized and microsized thin film structures that exhibit a high degree of smoothness useful for applications in microelectronics. Deposition processing of the invention utilize smoothing agents capable of selectively adjusting the relative rates of processes involved in thin film formation and growth to access enhanced nucleation densities resulting in smooth thin film structures, including ultrathin (e.g., <10 nm) smooth films. |
| FILED | Monday, October 31, 2011 |
| APPL NO | 13/285974 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/04 (20130101) C23C 16/18 (20130101) C23C 16/0272 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846225 | Sloop |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Steven E. Sloop (Bend, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven E. Sloop (Bend, Oregon) |
| ABSTRACT | Methods for making a recycled or refurbished electrode material for an energy-storage device are provided. One example method comprises harvesting a lithium-deficient electrode material from a recycling or waste stream, and replenishing at least some lithium in the lithium-deficient electrode material. A second example method comprises breeching an enclosure of a cell of an energy storage device, replenishing at least some lithium in a lithium-deficient electrode material of the cell, and sealing the enclosure of the cell. |
| FILED | Friday, February 20, 2009 |
| APPL NO | 12/390364 |
| ART UNIT | 1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Crushing, Pulverising, or Disintegrating in General; Milling Grain B02C 17/20 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/485 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/5825 (20130101) H01M 10/052 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/4242 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846329 | Pfleger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Brian Frederick Pfleger (Madison, Wisconsin); Matthew Brett Begemann (Madison, Wisconsin) |
| ABSTRACT | Organic acid-producing microorganisms and methods of using same. The organic acid-producing microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid, acrylic acid, propionic acid, lactic acid, and others. Further modifications to the microorganisms increase production of such organic acids as 3-hydroxypropionic acid, lactate, and others. Methods of producing such organic acids as 3-hydroxypropionic acid, lactate, and others with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers are also provided. |
| FILED | Friday, March 07, 2014 |
| APPL NO | 14/200686 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846331 | McNaughton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brandon H. McNaughton (Ann Arbor, Michigan); Paivo Kinnunen (Ann Arbor, Michigan); Raoul Kopelman (Ann Arbor, Michigan); Alan Hunt (Plymouth, Michigan); Roy Clarke (Ann Arbor, Michigan); Irene Sinn (Ann Arbor, Michigan); Remy Elbez (Ann Arbor, Michigan); Theodore Albertson (Bloomfield, Michigan) |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Brandon H. McNaughton (Ann Arbor, Michigan); Paivo Kinnunen (Ann Arbor, Michigan); Raoul Kopelman (Ann Arbor, Michigan); Alan Hunt (Plymouth, Michigan); Roy Clarke (Ann Arbor, Michigan); Irene Sinn (Ann Arbor, Michigan); Remy Elbez (Ann Arbor, Michigan); Theodore Albertson (Bloomfield, Michigan) |
| ABSTRACT | Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is descried. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also described herein are methods for controlling the illumination and imaging of rotating magnetic particles. |
| FILED | Monday, August 29, 2011 |
| APPL NO | 13/220381 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/29 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846354 | Pfleger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Brian Frederick Pfleger (Madison, Wisconsin); Matthew Brett Begemann (Madison, Wisconsin) |
| ABSTRACT | Organic acid-producing microorganisms and methods of using same. The organic acid-producing microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid, acrylic acid, propionic acid, lactic acid, and others. Further modifications to the microorganisms increase production of such organic acids as 3-hydroxypropionic acid, lactate, and others. Methods of producing such organic acids as 3-hydroxypropionic acid, lactate, and others with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers are also provided. |
| FILED | Friday, March 07, 2014 |
| APPL NO | 14/200747 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846404 | Odom et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Susan A. Odom (Champaign, Illinois); Mary M. Caruso (Urbana, Illinois); Aaron D. Finke (Urbana, Illinois); Aaron C. Jackson (Urbana, Illinois); Jeffrey S. Moore (Savoy, Illinois); Nancy R. Sottos (Champaign, Illinois); Scott R. White (Champaign, Illinois) |
| ASSIGNEE(S) | Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Susan A. Odom (Champaign, Illinois); Mary M. Caruso (Urbana, Illinois); Aaron D. Finke (Urbana, Illinois); Aaron C. Jackson (Urbana, Illinois); Jeffrey S. Moore (Savoy, Illinois); Nancy R. Sottos (Champaign, Illinois); Scott R. White (Champaign, Illinois) |
| ABSTRACT | A self-indicating material system may include a solid polymer matrix having a first color, a first plurality of capsules in the matrix, and a plurality of particles in the matrix. The first plurality of capsules includes a first reactant, and the plurality of particles includes a second reactant, which forms a product when in contact with the first reactant. When a crack forms in the polymer matrix, at least a portion of the first plurality of capsules is ruptured, the first and second reactants form the product in the matrix, and the portion of the polymer matrix containing the product has a second color different from the first color. A self-indicating material system may include a solid polymer matrix, a plurality of capsules in the matrix, and an activator in the matrix, where the polymer matrix includes a first polymer and has a first color, the plurality of capsules includes a polymerizer, and the activator is an activator for the polymerizer. When a crack forms in the polymer matrix, at least a portion of the plurality of capsules is ruptured, the polymerizer and the activator form a second polymer in the crack, and the second polymer has a second color different from the first color. |
| FILED | Friday, June 24, 2011 |
| APPL NO | 13/168166 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846619 | Dutton |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | P. Leslie Dutton (Media, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | P. Leslie Dutton (Media, Pennsylvania) |
| ABSTRACT | This invention provides heme-containing peptides capable of binding molecular oxygen at room temperature. These compounds may be useful in the absorption of molecular oxygen from molecular oxygen-containing atmospheres. Also included in the invention are methods for treating an oxygen transport deficiency in a mammal. |
| FILED | Thursday, March 04, 2010 |
| APPL NO | 13/254596 |
| ART UNIT | 1675 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/805 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846747 | Goldfarb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David S. Goldfarb (Victor, New York); Joseph A. Maddry (Birmingham, Alabama); Lynn Rasmussen (Odenville, Alabama); Ellie Lucille White (Birmingham, Alabama); Krister Wennerberg (Helsinki, Norway) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York); Southern Research Institute (Birmingham, Alabama) |
| INVENTOR(S) | David S. Goldfarb (Victor, New York); Joseph A. Maddry (Birmingham, Alabama); Lynn Rasmussen (Odenville, Alabama); Ellie Lucille White (Birmingham, Alabama); Krister Wennerberg (Helsinki, Norway) |
| ABSTRACT | Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation. |
| FILED | Wednesday, November 17, 2010 |
| APPL NO | 13/510166 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 49/403 (20130101) C07C 49/417 (20130101) C07C 49/543 (20130101) C07C 49/553 (20130101) C07C 49/567 (20130101) C07C 49/573 (20130101) C07C 49/577 (20130101) C07C 49/613 (20130101) C07C 49/657 (20130101) Original (OR) Class C07C 49/753 (20130101) C07C 49/792 (20130101) C07C 69/743 (20130101) C07C 69/757 (20130101) C07C 225/22 (20130101) C07C 235/82 (20130101) C07C 2101/02 (20130101) C07C 2101/08 (20130101) C07C 2101/14 (20130101) C07C 2102/42 (20130101) Heterocyclic Compounds C07D 209/12 (20130101) C07D 307/46 (20130101) C07D 307/54 (20130101) C07D 317/54 (20130101) C07D 319/18 (20130101) C07D 333/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846777 | Bowman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christopher Bowman (Boulder, Colorado); Neil Cramer (Boulder, Colorado); Robin Shandas (Boulder, Colorado); Devatha P. Nair (Lakewood, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| INVENTOR(S) | Christopher Bowman (Boulder, Colorado); Neil Cramer (Boulder, Colorado); Robin Shandas (Boulder, Colorado); Devatha P. Nair (Lakewood, Colorado) |
| ABSTRACT | A variety of biomedical devices are provided which include thiol-ene or thiol-yne shape memory polymers. The biomedical devices of the invention are capable of exhibiting shape memory behavior at physiological temperatures and may be used in surgical procedures. Methods of making the devices of the invention are also provided. |
| FILED | Wednesday, April 22, 2009 |
| APPL NO | 12/988983 |
| ART UNIT | 1763 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 59/16 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/46 (20130101) C08F 2/48 (20130101) C08F 2/50 (20130101) C08F 290/067 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/672 (20130101) Original (OR) Class Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 175/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846890 | Reguera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gemma Reguera (Lansing, Michigan); Rebecca Steidl (Williamston, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Gemma Reguera (Lansing, Michigan); Rebecca Steidl (Williamston, Michigan) |
| ABSTRACT | The application describes electrically conductive nanowires, as well as genetically and/or chemically modified nanowires with modified conductive, adhesive and/or coupling properties. |
| FILED | Tuesday, August 30, 2011 |
| APPL NO | 13/221495 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Original (OR) Class Peptides C07K 14/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846919 | Wolczanski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Peter T. Wolczanski (Ithaca, New York); Brenda A. Frazier (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Peter T. Wolczanski (Ithaca, New York); Brenda A. Frazier (Ithaca, New York) |
| ABSTRACT | The invention relates to di-aryl, di-heteroaryl or aryl-heteroaryl azaallyl compounds that are useful as chelates for metals. |
| FILED | Thursday, February 11, 2010 |
| APPL NO | 12/704170 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 401/12 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/02 (20130101) C07F 1/04 (20130101) C07F 3/02 (20130101) C07F 15/02 (20130101) C07F 15/025 (20130101) C07F 15/045 (20130101) C07F 15/0053 (20130101) C07F 15/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846950 | Veige et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Adam Steven Veige (Gainesville, Florida); Joseph Michael Falkowski (Chapel Hill, North Carolina); Matthew O'Reilly (Gainesville, Florida); Subramaniam Kuppuswamy (Gainesville, Florida); Kevin P. McGowan (Gainesville, Florida); Soumya Sarkar (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| INVENTOR(S) | Adam Steven Veige (Gainesville, Florida); Joseph Michael Falkowski (Chapel Hill, North Carolina); Matthew O'Reilly (Gainesville, Florida); Subramaniam Kuppuswamy (Gainesville, Florida); Kevin P. McGowan (Gainesville, Florida); Soumya Sarkar (Gainesville, Florida) |
| ABSTRACT | An embodiment of the invention is a novel Cr(V)OCO3− trianionic pincer ligand complex. Another embodiment of the invention is a catalytic method for oxidation of a substrate aerobically in the presence of a source of oxygen, where the novel Cr(V)OCO3− trianionic pincer ligand complex acts as the catalyst. The substrate can be a phosphine, amine, sulfide, alkene, alkane or a second metal complex. Another embodiment of the invention is directed to NCN pincer ligands that can form trianionic pincer ligand complexes. |
| FILED | Wednesday, March 03, 2010 |
| APPL NO | 13/254510 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Organic compounds 548/402 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846978 | Hotchkiss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Peter Hotchkiss (Washington, District of Columbia); Seth Marder (Atlanta, Georgia); Anthony Giordano (Atlanta, Georgia); Thomas D. Anthopoulos (London, United Kingdom) |
| ASSIGNEE(S) | Imperial Innovations Ltd. (London, United Kingdom); Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Peter Hotchkiss (Washington, District of Columbia); Seth Marder (Atlanta, Georgia); Anthony Giordano (Atlanta, Georgia); Thomas D. Anthopoulos (London, United Kingdom) |
| ABSTRACT | In some embodiments, the inventions described herein relate to a composition of matter comprising a molecule having the structure: wherein: independently at each occurrence, R1 is a halogen, a alkyl group, a heteroalkyl group, an aryl group, or a heteroaryl group; R2 comprises from 3 to 30 CH2— groups, n=0-5, m=0-5, q=1-3, and R2 comprises at least one ether linkage. |
| FILED | Friday, April 02, 2010 |
| APPL NO | 13/262739 |
| ART UNIT | 1671 — Organic Chemistry |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3808 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/004 (20130101) H01L 51/5088 (20130101) H01L 51/5203 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847066 | Holmes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Russell J. Holmes (Minneapolis, Minnesota); Richa Pandey (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Russell J. Holmes (Minneapolis, Minnesota); Richa Pandey (Minneapolis, Minnesota) |
| ABSTRACT | A photovoltaic device includes a first heterojunction layer having a first donor type organic material and a first acceptor type organic material, in which a concentration of at least one of the first donor type organic material and the first acceptor type organic material is graded continuously from a first side of the first heterojunction layer to a second side of the first heterojunction layer. |
| FILED | Wednesday, May 19, 2010 |
| APPL NO | 12/783308 |
| ART UNIT | 1757 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/4253 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847313 | Zhou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chongwu Zhou (Arcadia, California); Fumiaki Ishikawa (Torrance, California); Hsiao-Kang Chang (Los Angeles, California); Koungmin Ryu (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Chongwu Zhou (Arcadia, California); Fumiaki Ishikawa (Torrance, California); Hsiao-Kang Chang (Los Angeles, California); Koungmin Ryu (Los Angeles, California) |
| ABSTRACT | Methods and devices for transparent electronics are disclosed. According to an embodiment, transparent electronics are provided based on transfer printed carbon nanotubes that can be disposed on both rigid and flexible substrates. Methods are provided to enable highly aligned single-walled carbon nanotubes (SWNTs) to be used in transparent electronics for achieving high carrier mobility while using low-temperature processing. According to one method, highly aligned nanotubes can be grown on a first substrate. Then, the aligned nanotubes can be transferred to a rigid or flexible substrate having pre-patterned gate electrodes. Source and drain electrodes can be formed on the transferred nanotubes. The subject devices can be integrated to provide logic gates and analog circuitry for a variety of applications. |
| FILED | Monday, August 10, 2009 |
| APPL NO | 12/538597 |
| ART UNIT | 2822 — Semiconductors/Memory |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/003 (20130101) Original (OR) Class H01L 51/0048 (20130101) H01L 51/0541 (20130101) H01L 51/0545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847965 | Chandak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Anish Chandak (Carrboro, North Carolina); Lakulish Shailesh Antani (Chapel Hill, North Carolina); Micah Taylor (Pittsboro, North Carolina); Dinesh Manocha (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Anish Chandak (Carrboro, North Carolina); Lakulish Shailesh Antani (Chapel Hill, North Carolina); Micah Taylor (Pittsboro, North Carolina); Dinesh Manocha (Chapel Hill, North Carolina) |
| ABSTRACT | Methods, systems, and computer program products for simulating sound propagation can be operable to define a sound source position within a modeled scene having a given geometry and construct a visibility tree for modeling sound propagation paths within the scene. Using from-region visibility techniques to model sound diffraction and from-point visibility technique to model specular sound reflections within the scene, the size of the visibility tree can be reduced. Using the visibility tree, an impulse response can be generated for the scene, and the impulse response can be used to simulate sound propagation in the scene. |
| FILED | Monday, December 05, 2011 |
| APPL NO | 13/373901 |
| ART UNIT | 2617 — Electrical Circuits and Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 17/5009 (20130101) Image Data Processing or Generation, in General G06T 13/00 (20130101) Original (OR) Class G06T 13/40 (20130101) G06T 15/40 (20130101) Stereophonic Systems H04S 2400/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848006 | Wetzstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gordon Wetzstein (Cambridge, Massachusetts); Douglas Lanman (Somerville, Massachusetts); Matthew Hirsch (Somerville, Massachusetts); Ramesh Raskar (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Gordon Wetzstein (Cambridge, Massachusetts); Douglas Lanman (Somerville, Massachusetts); Matthew Hirsch (Somerville, Massachusetts); Ramesh Raskar (Cambridge, Massachusetts) |
| ABSTRACT | In exemplary implementations of this invention, an automultiscopic display device includes (1) one or more spatially addressable, light attenuating layers, and (2) a controller which is configured to perform calculations to control the device. In these calculations, tensors provide sparse, memory-efficient representations of a light field. The calculations include using weighted nonnegative tensor factorization (NTF) to solve an optimization problem. The NTF calculations can be sufficiently efficient to achieve interactive refresh rates. Either a directional backlight or a uniform backlight may be used. For example, the device may have (1) a high resolution LCD in front, and (2) a low resolution directional backlight. Or, for example, the device may have a uniform backlight and three or more LCD panels. In these examples, all of the LCDs and the directional backlight (if applicable) may be time-multiplexed. |
| FILED | Tuesday, January 08, 2013 |
| APPL NO | 13/736769 |
| ART UNIT | 2692 — Selective Visual Display Systems |
| CURRENT CPC | Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/3406 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848091 | Baraniuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Richard g. Baraniuk (Houston, Texas); Dror Z. Baron (Cary, North Carolina); Marco F. Duarte (Durham, North Carolina); Kevin F. Kelly (Houston, Texas); Courtney C. Lane (Ventura, California); Jason N. Laska (Houston, Texas); Dharmpal Takhar (Houston, Texas); Michael B. Wakin (Castle Rock, Colorado) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Richard g. Baraniuk (Houston, Texas); Dror Z. Baron (Cary, North Carolina); Marco F. Duarte (Durham, North Carolina); Kevin F. Kelly (Houston, Texas); Courtney C. Lane (Ventura, California); Jason N. Laska (Houston, Texas); Dharmpal Takhar (Houston, Texas); Michael B. Wakin (Castle Rock, Colorado) |
| ABSTRACT | A new digital image/video camera that directly acquires random projections of the incident light field without first collecting the pixels/voxels. In one preferred embodiment, the camera employs a digital micromirror array to perform optical calculations of linear projections of an image onto pseudorandom binary patterns. Its hallmarks include the ability to obtain an image with only a single detection element while measuring the image/video fewer times than the number of pixels or voxels—this can significantly reduce the computation required for image/video acquisition/encoding. Since the system features a single photon detector, it can also be adapted to image at wavelengths that are currently impossible with conventional CCD and CMOS imagers. |
| FILED | Wednesday, May 02, 2012 |
| APPL NO | 13/462212 |
| ART UNIT | 2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 25/20 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 3/08 (20130101) H04N 5/335 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848199 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wonshik Choi (Somerville, Massachusetts); Ramachandra Rao Dasari (Schererville, Indiana); Christopher M. Fang-Yen (Brookline, Massachusetts); Michael S. Feld (Jamaica Plain, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Wonshik Choi (Somerville, Massachusetts); Ramachandra Rao Dasari (Schererville, Indiana); Christopher M. Fang-Yen (Brookline, Massachusetts); Michael S. Feld (Jamaica Plain, Massachusetts) |
| ABSTRACT | The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering. |
| FILED | Thursday, July 10, 2008 |
| APPL NO | 12/218029 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Original (OR) Class G01N 21/51 (20130101) G01N 21/6458 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848754 | Botez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dan Botez (Madison, Wisconsin); Jae Cheol Shin (Gwangsan-gu, South Korea) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Dan Botez (Madison, Wisconsin); Jae Cheol Shin (Gwangsan-gu, South Korea) |
| ABSTRACT | Semiconductor structures for laser devices are provided. The semiconductor structures have a quantum cascade laser structure comprising an electron injector, an active region, and an electron extractor. The active region comprises an injection barrier, a multiquantum well structure, and an exit barrier. The multiquantum well structure can comprise a first barrier, a first quantum well, a second barrier, a second quantum well, and a third barrier. The energies of the first and second barrier are less than the energy of the third barrier. The energy difference between the energy of the second barrier and the energy of the third barrier can be greater than 150 meV and the ratio of the energy of the third barrier to the energy of the second barrier can be greater than 1.26. |
| FILED | Wednesday, August 22, 2012 |
| APPL NO | 13/591645 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/00 (20130101) H01S 5/20 (20130101) H01S 5/34 (20130101) H01S 5/2009 (20130101) H01S 5/2013 (20130101) H01S 5/3216 (20130101) H01S 5/3401 (20130101) Original (OR) Class H01S 5/3407 (20130101) H01S 5/3412 (20130101) H01S 5/3413 (20130101) H01S 5/3418 (20130101) H01S 5/3425 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848924 | Kohno et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tadayoshi Kohno (Seattle, Washington); Arvind Krishnamurthy (Seattle, Washington); Gabriel Maganis (Shoreline, Washington); Thomas Ristenpart (La Jolla, California) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Tadayoshi Kohno (Seattle, Washington); Arvind Krishnamurthy (Seattle, Washington); Gabriel Maganis (Shoreline, Washington); Thomas Ristenpart (La Jolla, California) |
| ABSTRACT | A privacy-preserving device-tracking system and method to assist in the recovery of lost or stolen Internet-connected mobile devices. The function of such a system seem contradictory, since it is desirable to hide a device's legitimately-visited locations from third-party services and other parties to achieve location privacy, while still enabling recovery of the device's location(s) after it goes missing by tracking the device to determine its location. An exemplary embodiment uses a DHT for storing encrypted location information and other forensic information in connection with indices that are successively determined based on initial pseudorandom seed information (i.e., state) that is retained by the owner of the device. Using the seed information, the software can determine indices mapped to location information stored after the device went missing, enabling the device to be located. Numerous extensions are discussed for the basic exemplary design that increase its suitability for particular deployment environments. |
| FILED | Monday, November 24, 2008 |
| APPL NO | 12/276829 |
| ART UNIT | 2453 — Computer Networks |
| CURRENT CPC | Electric Digital Data Processing G06F 17/3087 (20130101) G06F 17/30097 (20130101) G06F 17/30312 (20130101) G06F 17/30613 (20130101) G06F 17/30619 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/08 (20130101) Original (OR) Class H04L 9/30 (20130101) H04L 9/0883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849058 | Kennedy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lyndon Kennedy (San Francisco, California); Shih-Fu Chang (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (, None) |
| INVENTOR(S) | Lyndon Kennedy (San Francisco, California); Shih-Fu Chang (New York, New York) |
| ABSTRACT | Systems and methods are described for determining manipulation history among a plurality of images. The described techniques include selecting a pair of images from the plurality of images, detecting one or more manipulations operable to transform one of the images to the other, and based on the manipulations detected, determining a parent-child relationship between the pair or pairs of images. The described techniques can further include repeating the selecting two images, detecting manipulations, and determining the parent-child relationship for each pairs of images in the plurality of images, constructing a visual migration map for the images, and presenting the visual migration map in a user readable format. |
| FILED | Monday, August 23, 2010 |
| APPL NO | 12/861377 |
| ART UNIT | 2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0022 (20130101) Original (OR) Class G06T 7/2053 (20130101) G06T 11/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
08849076 — Method of optical self-switching using microresonator optical switch having nanoparticles
| US 08849076 | Digonnet et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Michel J. F. Digonnet (Palo Alto, California); Anuranjita Tewary (Palo Alto, California); Mark Brongersma (Redwood City, California) |
| ABSTRACT | An optical switch includes a microresonator comprising a plurality of silicon nanoparticles within a silicon-rich silicon oxide layer. The microresonator further includes an optical coupler optically coupled to the microresonator and configured to be optically coupled to a signal source. A method of optical switching includes providing an optical switch comprising an optical coupler and a microresonator having a plurality of nanoparticles and receiving an optical pulse by the optical switch, wherein at least a portion of the optical pulse is absorbed by the nanoparticles such that at least a portion of the microresonator undergoes an elevation of temperature and a corresponding refractive index change when the optical pulse has an optical power greater than a predetermined threshold level. |
| FILED | Friday, July 12, 2013 |
| APPL NO | 13/941399 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/29341 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849229 | Behdad |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nader Behdad (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Nader Behdad (Madison, Wisconsin) |
| ABSTRACT | An electrically small receiver system is provided. The receiver system includes a plurality of antennas and a signal processing circuit. The plurality of antennas includes a first antenna configured to receive a first signal and a second antenna configured to receive a second signal. The signal processing circuit includes a phase shifter configured to apply a phase shift to the received second signal. The phase shift applied by the phase shifter is a function of an angle of incidence of the second signal measured relative to a boresight direction of the plurality of antennas. The signal processing circuit is configured to form an output signal that is a combination of the received first signal and the phase shifted second signal. |
| FILED | Friday, June 01, 2012 |
| APPL NO | 13/486269 |
| ART UNIT | 2649 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Telecommunications 455/242.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849626 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ratnesh Kumar (Ames, Iowa); Meng Li (Ames, Iowa) |
| ASSIGNEE(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| INVENTOR(S) | Ratnesh Kumar (Ames, Iowa); Meng Li (Ames, Iowa) |
| ABSTRACT | A method of translation of a chart associated with a graphical modeling environment into an input/output-extended finite automata (I/O-EFA) model is provided. The method includes receiving a representation of the chart and processing the representation of the chart with a computing device by (a) representing atomic models for each individual state of the chart, (b) applying composition rules to interconnect the atomic models while preserving state execution and transition behaviors to obtain the I/O-EFA model. |
| FILED | Friday, June 29, 2012 |
| APPL NO | 13/538472 |
| ART UNIT | 2128 — AI & Simulation/Modeling |
| CURRENT CPC | Data processing: Structural design, modeling, simulation, and emulation 73/2 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08850608 | Tehranipoor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mohammad Tehranipoor (Mansfield, Connecticut); Xiaoxiao Wang (Austin, Texas); Xuehui Zhang (Storrs, Connecticut) |
| ASSIGNEE(S) | University of Connecticut (Farmington, Connecticut) |
| INVENTOR(S) | Mohammad Tehranipoor (Mansfield, Connecticut); Xiaoxiao Wang (Austin, Texas); Xuehui Zhang (Storrs, Connecticut) |
| ABSTRACT | Aspects of the disclosure relate to combining on-chip structure with external current measurements for threat detection in an integrated circuit. This method considers Trojans' impact on neighboring cells and on the entire IC's power consumption, and effectively localizes the measurement of dynamic power. An on-chip structure can permit threat detections. In one aspect, the on-chip structure can comprise a plurality of sensors distributed across the entirety of the IC, with each sensor of the plurality of sensors being placed in different rows of a standard-cell design. In another aspect, data analysis can permit separating effect of process variations on transient power usage of the IC from effects of a hardware threat such power usage. The on-chip structure also can be employed for implementation of a PE-PUF. |
| FILED | Wednesday, March 07, 2012 |
| APPL NO | 13/414673 |
| ART UNIT | 2496 — Cryptography and Security |
| CURRENT CPC | Pulse Technique H03K 3/0315 (20130101) Original (OR) Class H03K 3/0322 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/0995 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0662 (20130101) H04L 2209/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 08844281 | Browne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alan L. Browne (Grosse Pointe, Michigan); Nancy L. Johnson (Northville, Michigan); John Andrew Shaw (Dexter, Michigan); Christopher Burton Churchill (Ann Arbor, Michigan); Andrew C. Keefe (Encino, California); Geoffrey P. McKnight (Los Angeles, California); Paul W. Alexander (Ypsilanti, Michigan); Guillermo A. Herrera (Winnetka, California); James Ryan Yates (Mission Viejo, California); Jeffrey W. Brown (Los Gatos, California) |
| ASSIGNEE(S) | GM Global Technology Operations LLC (Detroit, Michigan); Dynalloy, Inc (Tustin, California); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Alan L. Browne (Grosse Pointe, Michigan); Nancy L. Johnson (Northville, Michigan); John Andrew Shaw (Dexter, Michigan); Christopher Burton Churchill (Ann Arbor, Michigan); Andrew C. Keefe (Encino, California); Geoffrey P. McKnight (Los Angeles, California); Paul W. Alexander (Ypsilanti, Michigan); Guillermo A. Herrera (Winnetka, California); James Ryan Yates (Mission Viejo, California); Jeffrey W. Brown (Los Gatos, California) |
| ABSTRACT | A heat engine includes a first rotatable pulley and a second rotatable pulley spaced from the first rotatable pulley. A shape memory alloy (SMA) element is disposed about respective portions of the pulleys at an SMA pulley ratio. The SMA element includes a first wire, a second wire, and a matrix joining the first wire and the second wire. The first wire and the second wire are in contact with the pulleys, but the matrix is not in contact with the pulleys. A timing cable is disposed about respective portions of the pulleys at a timing pulley ratio, which is different than the SMA pulley ratio. The SMA element converts a thermal energy gradient between the hot region and the cold region into mechanical energy. |
| FILED | Friday, December 30, 2011 |
| APPL NO | 13/340964 |
| ART UNIT | 3748 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) Original (OR) Class F03G 7/065 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 420/902 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08844331 | Golovashchenko |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sergey Fedorovich Golovashchenko (Beverly Hills, Michigan) |
| ASSIGNEE(S) | Ford Global Technologies, LLC (Dearborn, Michigan) |
| INVENTOR(S) | Sergey Fedorovich Golovashchenko (Beverly Hills, Michigan) |
| ABSTRACT | A system for electro-hydraulically forming a sheet metal part in an electro-hydraulic forming (EHF) machine. The part in a first shape is placed in the EHF machine between a one-sided forming die and a chamber that is filled with a liquid. An electrode is discharged in the chamber to form the part toward the forming die. The electrode is advanced within the chamber toward the part and a subsequent discharge is provided in the chamber to form the part. A gap discharge EHF machine and a wire discharge EHF machine may be used in the system. |
| FILED | Friday, October 29, 2010 |
| APPL NO | 12/915110 |
| ART UNIT | 3725 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 26/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08844366 | Warren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oden Lee Warren (New Brighton, Minnesota); Syed Amanulla Syed Asif (Bloomington, Minnesota); Yunje Oh (Medina, Minnesota); Yuxin Feng (Plymouth, Minnesota); Edward Cyrankowski (Woodbury, Minnesota); Ryan Major (Crystal, Minnesota) |
| ASSIGNEE(S) | Hysitron, Inc. (Eden Prairie, Minnesota) |
| INVENTOR(S) | Oden Lee Warren (New Brighton, Minnesota); Syed Amanulla Syed Asif (Bloomington, Minnesota); Yunje Oh (Medina, Minnesota); Yuxin Feng (Plymouth, Minnesota); Edward Cyrankowski (Woodbury, Minnesota); Ryan Major (Crystal, Minnesota) |
| ABSTRACT | A testing instrument for mechanical testing at nano or micron scale includes a transducer body, and a coupling shaft coupled with a probe tip. A transducer body houses a capacitor. The capacitor includes first and second counter electrodes and a center electrode assembly interposed therebetween. The center electrode assembly is movable with the coupling shaft relative to the first and second counter electrodes, for instance in one or more of dimensions including laterally and normally. The center electrode assembly includes a center plate coupled with the coupling shaft and one or more springs extending from the center plate. Upper and lower plates are coupled with the center plate and cover the center plate and the one or more springs. A shaft support assembly includes one or more support elements coupled along the coupling shaft. The shaft support assembly provides lateral support to the coupling shaft. |
| FILED | Friday, March 09, 2012 |
| APPL NO | 14/004138 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 7/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08844422 | Klett |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | James W. Klett (Knoxville, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | James W. Klett (Knoxville, Tennessee) |
| ABSTRACT | Disclosed are several examples of apparatuses for suppressing the blast and flash produced as a projectile is expelled by gases from a firearm. In some examples, gases are diverted away from the central chamber to an expansion chamber by baffles. The gases are absorbed by the expansion chamber and desorbed slowly, thus decreasing pressure and increasing residence time of the gases. In other examples, the gases impinge against a plurality of rods before expanding through passages between the rods to decrease the pressure and increase the residence time of the gases. |
| FILED | Thursday, September 06, 2012 |
| APPL NO | 13/604949 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 21/30 (20130101) F41A 21/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08844748 | Blanton |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paul S. Blanton (Aiken, South Carolina) |
| ASSIGNEE(S) | Savannah River Nuclear Solutions, LLC (Aiken, South Carolina) |
| INVENTOR(S) | Paul S. Blanton (Aiken, South Carolina) |
| ABSTRACT | Closure ring to retain a lid in contact with a metal drum in central C-section conforming to the contact area between a lid and the rim of a drum and further having a radially inwardly directed flange and a vertically downwardly directed flange attached to the opposite ends of the C-section. The additional flanges reinforce the top of the drum by reducing deformation when the drum is dropped and maintain the lid in contact with the drum. The invention is particularly valuable in transportation and storage of fissile material. |
| FILED | Monday, May 16, 2005 |
| APPL NO | 11/130043 |
| ART UNIT | 3781 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 45/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08844938 | Brown |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC. (Livermore, California) |
| INVENTOR(S) | Erik P. Brown (Tracy, California) |
| ABSTRACT | A system seals a filter or equipment component to a base and will continue to seal the filter or equipment component to the base in the event of hot air or fire. The system includes a first sealing material between the filter or equipment component and the base; and a second sealing material between the filter or equipment component and the base and proximate the first sealing material. The first sealing material and the second seal material are positioned relative to each other and relative to the filter or equipment component and the base to seal the filter or equipment component to the base and upon the event of fire the second sealing material will be activated and expand to continue to seal the filter or equipment component to the base in the event of hot air or fire. |
| FILED | Monday, November 12, 2012 |
| APPL NO | 13/674622 |
| ART UNIT | 3675 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Pistons; Cylinders; Sealings F16J 15/008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845878 | Cole et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Liquid Light, Inc. (Monmouth Junction, New Jersey) |
| ASSIGNEE(S) | Liquid Light, Inc. (Monmouth Junction, New Jersey) |
| INVENTOR(S) | Emily Barton Cole (Houston, Texas); Narayanappa Sivasankar (Plainsboro, New Jersey); Rishi Parajuli (Kendell Park, New Jersey); Kate A. Keets (Lawrenceville, New Jersey) |
| ABSTRACT | A method reducing carbon dioxide to one or more products may include steps (A) to (C). Step (A) may bubble said carbon dioxide into a solution of an electrolyte and a catalyst in a divided electrochemical cell. The divided electrochemical cell may include an anode in a first cell compartment and a cathode in a second cell compartment. The cathode may reduce said carbon dioxide into said products. Step (B) may adjust one or more of (a) a cathode material, (b) a surface morphology of said cathode, (c) said electrolyte, (d) a manner in which said carbon dioxide is bubbled, (e), a pH level of said solution, and (f) an electrical potential of said divided electrochemical cell, to vary at least one of (i) which of said products is produced and (ii) a faradaic yield of said products. Step (C) may separate said products from said solution. |
| FILED | Wednesday, March 06, 2013 |
| APPL NO | 13/787304 |
| ART UNIT | 1756 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/00 (20130101) Original (OR) Class C25B 1/003 (20130101) C25B 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845923 | Pylkkanen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | API Intellectual Property Holdings, LLC (Atlanta, Georgia) |
| ASSIGNEE(S) | API Intellectual Property Holdings, LLC (Atlanta, Georgia) |
| INVENTOR(S) | Vesa Pylkkanen (Atlanta, Georgia); Kimberly Nelson (Atlanta, Georgia) |
| ABSTRACT | In some variations, the invention provides a deicer composition comprising alkali acetate, a solvent (such as water) for the alkali acetate, and a corrosion inhibitor comprising lignin or a lignin derivative. The acetate and the lignin or lignin derivative are preferably each derived from the same biomass feedstock. In some embodiments, the alkali is selected from the group consisting of potassium, sodium, magnesium, calcium, and combinations thereof. In some embodiments, the alkali acetate is present in a concentration from about 30 wt % to about 99 wt %. Deicer products may be a crystallized or dried form of the deicer composition. |
| FILED | Friday, December 27, 2013 |
| APPL NO | 14/141421 |
| ART UNIT | 1731 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 51/41 (20130101) C07C 51/412 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 3/18 (20130101) Original (OR) Class C09K 3/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845999 | Wright et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ernest M. Wright (Los Angeles, California); Jorge R. Barrio (Agoura Hills, California); Bruce A. Hirayama (Los Angeles, California); Vladimir Kepe (Los Angeles, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ernest M. Wright (Los Angeles, California); Jorge R. Barrio (Agoura Hills, California); Bruce A. Hirayama (Los Angeles, California); Vladimir Kepe (Los Angeles, California) |
| ABSTRACT | Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with 18F, 123I, or 124I, or free hexoses radiolabeled with 18F, 123I, or 124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions. |
| FILED | Tuesday, May 23, 2006 |
| APPL NO | 11/920904 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) Original (OR) Class G01N 33/6872 (20130101) G01N 2400/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846206 | James et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Allister W. James (Orlando, Florida); Douglas J. Arrell (Ovieco, Florida) |
| ASSIGNEE(S) | Siemens Energy, Inc. (Orlando, Florida) |
| INVENTOR(S) | Allister W. James (Orlando, Florida); Douglas J. Arrell (Ovieco, Florida) |
| ABSTRACT | An intermediate component includes a first wall member, a leachable material layer, and a precursor wall member. The first wall member has an outer surface and first connecting structure. The leachable material layer is provided on the first wall member outer surface. The precursor wall member is formed adjacent to the leachable material layer from a metal powder mixed with a binder material, and includes second connecting structure. |
| FILED | Thursday, July 31, 2008 |
| APPL NO | 12/183185 |
| ART UNIT | 1784 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Alloys C22C 19/03 (20130101) Original (OR) Class C22C 19/07 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846329 | Pfleger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Brian Frederick Pfleger (Madison, Wisconsin); Matthew Brett Begemann (Madison, Wisconsin) |
| ABSTRACT | Organic acid-producing microorganisms and methods of using same. The organic acid-producing microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid, acrylic acid, propionic acid, lactic acid, and others. Further modifications to the microorganisms increase production of such organic acids as 3-hydroxypropionic acid, lactate, and others. Methods of producing such organic acids as 3-hydroxypropionic acid, lactate, and others with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers are also provided. |
| FILED | Friday, March 07, 2014 |
| APPL NO | 14/200686 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846351 | Quinlan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jason Quinlan (Woodland, California); Feng Xu (Davis, California); Matthew Sweeney (Sacramento, California); Katja Salomon Johansen (Gentofte, Denmark) |
| ASSIGNEE(S) | Novozymes, Inc. (Davis, California); Novozymes A/S (Bagsvaerd, Denmark) |
| INVENTOR(S) | Jason Quinlan (Woodland, California); Feng Xu (Davis, California); Matthew Sweeney (Sacramento, California); Katja Salomon Johansen (Gentofte, Denmark) |
| ABSTRACT | The present invention relates to compositions comprising a GH61 polypeptide having cellulolytic enhancing activity and an organic compound comprising a carboxylic acid moiety, a lactone moiety, a phenolic moiety, a flavonoid moiety, or a combination thereof, wherein the combination of the GH61 polypeptide having cellulolytic enhancing activity and the organic compound enhances hydrolysis of a cellulosic material by a cellulolytic enzyme compared to the GH61 polypeptide alone or the organic compound alone. The present invention also relates to methods of using the compositions. |
| FILED | Friday, August 05, 2011 |
| APPL NO | 13/816432 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/99 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846354 | Pfleger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Brian Frederick Pfleger (Madison, Wisconsin); Matthew Brett Begemann (Madison, Wisconsin) |
| ABSTRACT | Organic acid-producing microorganisms and methods of using same. The organic acid-producing microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid, acrylic acid, propionic acid, lactic acid, and others. Further modifications to the microorganisms increase production of such organic acids as 3-hydroxypropionic acid, lactate, and others. Methods of producing such organic acids as 3-hydroxypropionic acid, lactate, and others with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers are also provided. |
| FILED | Friday, March 07, 2014 |
| APPL NO | 14/200747 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846369 | Piven et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Algenol Biofuels Inc. (Fort Myers, Florida) |
| ASSIGNEE(S) | Algenol Biofuels Inc. (Ft. Myers, Florida) |
| INVENTOR(S) | Irina Piven (Berlin, Germany); Alexandra Friedrich (Berlin, Germany); Ulf Dühring (Berlin, Germany); Frank Uliczka (Berlin, Germany); Kerstin Baier (Kleinmachnow, Germany); Masami Inaba (Berlin, Germany); Tuo Shi (San Diego, California); Kui Wang (Fort Meyers, Florida); Heike Enke (Berlin, Germany); Dan Kramer (Berlin, Germany) |
| ABSTRACT | A cyanobacterial host cell, Cyanobacterium sp., that harbors at least one recombinant gene for the production of a chemical compounds is provided, as well as vectors derived from an endogenous plasmid isolated from the cell. |
| FILED | Monday, September 30, 2013 |
| APPL NO | 14/041122 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/243 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846406 | Martin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | James E. Martin (Tijeras, New Mexico); Douglas H. Read (Bosque Farms, New Mexico) |
| ASSIGNEE(S) | Sandia Corporation (Albuquerque, New Mexico) |
| INVENTOR(S) | James E. Martin (Tijeras, New Mexico); Douglas H. Read (Bosque Farms, New Mexico) |
| ABSTRACT | The sensitivity of a chemiresistor sensor can be dynamically tuned using mechanical strain. The increase in sensitivity is a smooth, continuous function of the applied strain, and the effect can be reversible. Sensitivity tuning enables the response curve of the sensor to be dynamically optimized for sensing analytes, such as volatile organic compounds, over a wide concentration range. |
| FILED | Thursday, January 19, 2012 |
| APPL NO | 13/353941 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/149 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846619 | Dutton |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | P. Leslie Dutton (Media, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | P. Leslie Dutton (Media, Pennsylvania) |
| ABSTRACT | This invention provides heme-containing peptides capable of binding molecular oxygen at room temperature. These compounds may be useful in the absorption of molecular oxygen from molecular oxygen-containing atmospheres. Also included in the invention are methods for treating an oxygen transport deficiency in a mammal. |
| FILED | Thursday, March 04, 2010 |
| APPL NO | 13/254596 |
| ART UNIT | 1675 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/805 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846629 | Desprez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pierre-Yves Desprez (Richmond, California); Judith Campisi (Berkeley, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); California Pacific Medical Center Research Institute (San Francisco, California) |
| INVENTOR(S) | Pierre-Yves Desprez (Richmond, California); Judith Campisi (Berkeley, California) |
| ABSTRACT | A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression. |
| FILED | Tuesday, December 02, 2008 |
| APPL NO | 12/326832 |
| ART UNIT | 1674 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2300/156 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5743 (20130101) G01N 33/57407 (20130101) G01N 33/57415 (20130101) G01N 33/57434 (20130101) G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846888 | Brown et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Novozymes, Inc. (Davis, California) |
| ASSIGNEE(S) | Novozymes, Inc. (Davis, California) |
| INVENTOR(S) | Kimberly Brown (Elk Grove, California); Paul Harris (Carnation, Washington); Elizabeth Zaretsky (Reno, Nevada); Edward Re (Davis, California); Elena Vlasenko (Davis, California); Keith McFarland (Davis, California); Alfredo Lopez de Leon (Davis, California) |
| ABSTRACT | The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. |
| FILED | Friday, October 12, 2012 |
| APPL NO | 13/650954 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 14/37 (20130101) Detergent Compositions; Use of Single Substances as Detergents; Soap or Soap-making; Resin Soaps; Recovery of Glycerol C11D 3/38645 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2437 (20130101) C12N 9/2445 (20130101) Enzymes C12Y 302/01021 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/16 (20130101) Y02E 50/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847631 | Tao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fengfeng Tao (Clifton Park, New York); Seyed Gholamali Saddoughi (Clifton Park, New York); John Thomas Herbon (Loveland, Ohio) |
| ASSIGNEE(S) | General Electric Company (Niskayuna, New York) |
| INVENTOR(S) | Fengfeng Tao (Clifton Park, New York); Seyed Gholamali Saddoughi (Clifton Park, New York); John Thomas Herbon (Loveland, Ohio) |
| ABSTRACT | A gate drive circuit includes an insulated gate semiconductor switch. A controlled current source is connected to the semiconductor switch gate terminal to provide a gate drive circuit that is responsive to recycled gate charge corresponding to an internal gate capacitance of the insulated gate semiconductor switch. |
| FILED | Friday, December 23, 2011 |
| APPL NO | 13/336669 |
| ART UNIT | 2842 — Electrical Circuits and Systems |
| CURRENT CPC | Miscellaneous active electrical nonlinear devices, circuits, and systems 327/108 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847647 | Buckler |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Micro Devices, Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Sunnyvale, California) |
| INVENTOR(S) | Mark Buckler (Acton, Massachusetts) |
| ABSTRACT | An input signal and a reset signal are provided to respective inputs of a resettable flip-flop. The resettable flip-flop generates an output signal. The output signal transitions from a first logic state to a second logic state in response to corresponding transitions of the input signal and transitions from the second logic state to the first logic state in response to assertion of the reset signal. A warning signal is asserted in response to transitions of the input signal from the second logic state to the first logic state. A logic gate forwards the output signal when the warning signal is de-asserted and provides a signal in the first logic state in response to assertion of the warning signal. |
| FILED | Wednesday, September 11, 2013 |
| APPL NO | 14/024396 |
| ART UNIT | 2842 — Electrical Circuits and Systems |
| CURRENT CPC | Pulse Technique H03K 3/356008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847824 | Kotter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dale K. Kotter (Shelley, Idaho); Steven D. Novack (Idaho Falls, Idaho) |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Dale K. Kotter (Shelley, Idaho); Steven D. Novack (Idaho Falls, Idaho) |
| ABSTRACT | An energy conversion device may include a first antenna and a second antenna configured to generate an AC current responsive to incident radiation, at least one stripline, and a rectifier coupled with the at least one stripline along a length of the at least one stripline. An energy conversion device may also include an array of nanoantennas configured to generate an AC current in response to receiving incident radiation. Each nanoantenna of the array includes a pair of resonant elements, and a shared rectifier operably coupled to the pair of resonant elements, the shared rectifier configured to convert the AC current to a DC current. The energy conversion device may further include a bus structure operably coupled with the array of nanoantennas and configured to receive the DC current from the array of nanoantennas and transmit the DC current away from the array of nanoantennas. |
| FILED | Wednesday, March 21, 2012 |
| APPL NO | 13/426407 |
| ART UNIT | 2845 — Electrical Circuits and Systems |
| CURRENT CPC | Communications: Radio wave antennas 343/700.MS0 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848871 | Chapman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeffrey Allen Chapman (Knoxville, Tennessee); John E. Gunning (Oak Ridge, Tennessee); Daniel F. Hollenbach (Oak Ridge, Tennessee); Larry J. Ott (Knoxville, Tennessee); Daniel Shedlock (Knoxville, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Jeffrey Allen Chapman (Knoxville, Tennessee); John E. Gunning (Oak Ridge, Tennessee); Daniel F. Hollenbach (Oak Ridge, Tennessee); Larry J. Ott (Knoxville, Tennessee); Daniel Shedlock (Knoxville, Tennessee) |
| ABSTRACT | The energy of an X-ray beam and critical depth are selected to detect structural discontinuities in a material having an atomic number Z of 57 or greater. The critical depth is selected by adjusting the geometry of a collimator that blocks backscattered radiation so that backscattered X-ray originating from a depth less than the critical depth is not detected. Structures of Lanthanides and Actinides, including nuclear fuel rod materials, can be inspected for structural discontinuities such as gaps, cracks, and chipping employing the backscattered X-ray. |
| FILED | Thursday, November 03, 2011 |
| APPL NO | 13/288168 |
| ART UNIT | 2882 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/203 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848905 | Hamlet et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jason R. Hamlet (Albuquerque, New Mexico); Todd M. Bauer (Albuquerque, New Mexico); Lyndon G. Pierson (Albuquerque, New Mexico) |
| ASSIGNEE(S) | Sandia Corporation (Albuquerque, New Mexico) |
| INVENTOR(S) | Jason R. Hamlet (Albuquerque, New Mexico); Todd M. Bauer (Albuquerque, New Mexico); Lyndon G. Pierson (Albuquerque, New Mexico) |
| ABSTRACT | Deterrence of device subversion by substitution may be achieved by including a cryptographic fingerprint unit within a computing device for authenticating a hardware platform of the computing device. The cryptographic fingerprint unit includes a physically unclonable function (“PUF”) circuit disposed in or on the hardware platform. The PUF circuit is used to generate a PUF value. A key generator is coupled to generate a private key and a public key based on the PUF value while a decryptor is coupled to receive an authentication challenge posed to the computing device and encrypted with the public key and coupled to output a response to the authentication challenge decrypted with the private key. |
| FILED | Wednesday, July 28, 2010 |
| APPL NO | 12/844860 |
| ART UNIT | 2453 — Computer Networks |
| CURRENT CPC | Secret Communication; Jamming of Communication H04K 1/04 (20130101) Original (OR) Class H04K 1/06 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/00 (20130101) H04L 9/3278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849451 | Rizzi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alfred Anthony Rizzi (Belmont, Massachusetts); Michael Patrick Murphy (Cambridge, Massachusetts); John Joseph Giarratana (Whitman, Massachusetts); Matthew David Malchano (Somervill, Massachusetts); Christian Allen Weagle (Malden, Massachusetts); Chris Aaron Richburg (Somerville, Massachusetts) |
| ASSIGNEE(S) | Boston Dynamics, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Alfred Anthony Rizzi (Belmont, Massachusetts); Michael Patrick Murphy (Cambridge, Massachusetts); John Joseph Giarratana (Whitman, Massachusetts); Matthew David Malchano (Somervill, Massachusetts); Christian Allen Weagle (Malden, Massachusetts); Chris Aaron Richburg (Somerville, Massachusetts) |
| ABSTRACT | A robot includes a chassis, a motive subsystem configured to maneuver the chassis, a hopping actuator attached to the chassis and configured to launch the robot, and at least one leg pivotable with respect to the chassis to pitch the chassis upward at a selected launch trajectory angle. A control subsystem automatically actuates and controls the motive subsystem when the robot is airborne and uses the rotational momentum of the motive subsystem to control the attitude of the robot chassis in flight. |
| FILED | Monday, April 11, 2011 |
| APPL NO | 13/066276 |
| ART UNIT | 3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Vehicle Wheels; Castors; Axles for Wheels or Castors; Increasing Wheel Adhesion B60B 15/02 (20130101) B60B 15/08 (20130101) Motor Vehicles; Trailers B62D 57/028 (20130101) Original (OR) Class Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08850583 | Nelson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trent Darnel Nelson (Ammon, Idaho); Jedediah Haile (Idaho Falls, Idaho) |
| ASSIGNEE(S) | U.S. Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Trent Darnel Nelson (Ammon, Idaho); Jedediah Haile (Idaho Falls, Idaho) |
| ABSTRACT | A method and device for intrusion detection using secure signatures comprising capturing network data. A search hash value, value employing at least one one-way function, is generated from the captured network data using a first hash function. The presence of a search hash value match in a secure signature table comprising search hash values and an encrypted rule is determined. After determining a search hash value match, a decryption key is generated from the captured network data using a second hash function, a hash function different form the first hash function. One or more of the encrypted rules of the secure signatures table having a hash value equal to the generated search hash value are then decrypted using the generated decryption key. The one or more decrypted secure signature rules are then processed for a match and one or more user notifications are deployed if a match is identified. |
| FILED | Tuesday, March 05, 2013 |
| APPL NO | 13/785349 |
| ART UNIT | 2437 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08850611 | Rose et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UChicago Argonne, LLC (Argonne, Illinois) |
| ASSIGNEE(S) | UChicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | Volker Rose (Downers Grove, Illinois); Curt A. Preissner (Chicago, Illinois); Saw-Wai Hla (Chicago, Illinois); Kangkang Wang (Fremont, California); Daniel Rosenmann (Naperville, Illinois) |
| ABSTRACT | A method and system for performing simultaneous topographic and elemental chemical and magnetic contrast analysis in a scanning, tunneling microscope. The method and system also includes nanofabricated coaxial multilayer tips with a nanoscale conducting apex and a programmable in-situ nanomanipulator to fabricate these tips and also to rotate tips controllably. |
| FILED | Friday, March 08, 2013 |
| APPL NO | 13/791157 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Scanning-probe techniques or apparatus; applications of scanning-probe techniques, e.g., Scanning probe microscopy [SPM] 850/29 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 08844345 | Southward et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stephen C. Southward (Danville, Virginia); Chandler Reubush (Toano, Virginia); Bryan Pittman (Thomasville, North Carolina); Kurt Roehrig (Lexington, North Carolina); Doug Gerard (Gillette, Wyoming) |
| ASSIGNEE(S) | Roehrig Engineering, Inc. (Lexington, North Carolina); Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| INVENTOR(S) | Stephen C. Southward (Danville, Virginia); Chandler Reubush (Toano, Virginia); Bryan Pittman (Thomasville, North Carolina); Kurt Roehrig (Lexington, North Carolina); Doug Gerard (Gillette, Wyoming) |
| ABSTRACT | An apparatus imparts motion to a test object such as a motor vehicle in a controlled fashion. A base has mounted on it a linear electromagnetic motor having a first end and a second end, the first end being connected to the base. A pneumatic cylinder and piston combination have a first end and a second end, the first end connected to the base so that the pneumatic cylinder and piston combination is generally parallel with the linear electromagnetic motor. The second ends of the linear electromagnetic motor and pneumatic cylinder and piston combination being commonly linked to a mount for the test object. A control system for the linear electromagnetic motor and pneumatic cylinder and piston combination drives the pneumatic cylinder and piston combination to support a substantial static load of the test object and the linear electromagnetic motor to impart controlled motion to the test object. |
| FILED | Tuesday, October 25, 2011 |
| APPL NO | 13/280532 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/117.30 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08844370 | Karon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Concepts ETI, Inc. (White River Junction, Vermont) |
| ASSIGNEE(S) | Concepts ETI, Inc. (White River Junction, Vermont) |
| INVENTOR(S) | David M. Karon (South Royalton, Vermont); Vincent Cushing (Annapolis, Maryland); Sandeep K. Patel (Madison, Alabama) |
| ABSTRACT | An electromagnetic flow meter (EMFM) accurately measures both the complete flow rate and the dynamically fluctuating flow rate of a fluid by applying a unipolar DC voltage to excitation coils for a predetermined period of time, measuring the electric potential at a pair of electrodes, determining a complete flow rate and independently measuring the dynamic flow rate during the “on” cycle of the DC excitation, and correcting the measurements for errors resulting from galvanic drift and other effects on the electric potential. The EMFM can also correct for effects from the excitation circuit induced during operation of the EMFM. |
| FILED | Friday, March 14, 2014 |
| APPL NO | 14/212967 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/58 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845768 | Wachsman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eric D. Wachsman (Fulton, Maryland); Heesung Yoon (Gainesville, Florida); Takkeun Oh (Gainesville, Florida); Jianlin Li (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| INVENTOR(S) | Eric D. Wachsman (Fulton, Maryland); Heesung Yoon (Gainesville, Florida); Takkeun Oh (Gainesville, Florida); Jianlin Li (Gainesville, Florida) |
| ABSTRACT | In one embodiment, a membrane of proton-electron conducting ceramics that is useful for the conversion of a hydrocarbon and steam to hydrogen has a porous support of M′-Sr1-z′M″z′Ce1-x′-y′Zrx′M′″y′O3-δ, Al2O3, mullite, ZrO2, CeO2 or any mixtures thereof where: M′ is Ni, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Nb, Mo, W, Zn, Pt, Ru, Rh, Pd, alloys thereof or mixtures thereof; M″ is Ba, Ca, Mg, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, or Yb; M′″ is Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Nb, Mo, W, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, or Yb; z′ is 0 to about 0.5; x′ is 0 to about 0.5; y′ is 0 to about 0.5; and x′+y′>0; for example, Ni—SrCe1-x′Zrx′O3-δ, where x′ is about 0.1 to about 0.3. The porous support is coated with a film of a Perovskite-type oxide of the formula SrCe1-x-yZrxMyO3-δ where M is at least one of Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Nb, Mo, W, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, and Yb, x is 0 to about 0.15 and y is about 0.1 to about 0.3. By including the Zr and M in the oxide in place of Ce, the stability can be improved while maintaining sufficient hydrogen flux for efficient generation of hydrogen. In this manner, the conversion can be carried out by performing steam methane reforming (SMR) and/or water-gas shift reactions (WGS) at high temperature, where the conversion of CO to CO2 and H2 is driven by the removal of H2 to give high conversions. Methods of preparing the membrane cells and a system for use of the membrane cells to prepare hydrogen are presented. A method for sequestering CO2 by reaction with methane or other hydrocarbon catalyzed by the novel membrane to form a syngas is also presented. |
| FILED | Wednesday, June 10, 2009 |
| APPL NO | 12/996687 |
| ART UNIT | 1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Gas: Heating and illuminating 048/61 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08845979 | Tai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yu-Chong Tai (Pasadena, California); Wendian Shi (Pasadena, California); Luke Guo (San Diego, California) |
| ASSIGNEE(S) | California Institute of Technology (Padasena, California) |
| INVENTOR(S) | Yu-Chong Tai (Pasadena, California); Wendian Shi (Pasadena, California); Luke Guo (San Diego, California) |
| ABSTRACT | The present invention provides a method of forming a blood-clot microvalve by heating blood in a capillary tube of a microfluidic device. Also described are methods of modulating liquid flow in a capillary tube by forming and removing a blood-clot microvalve. |
| FILED | Wednesday, September 14, 2011 |
| APPL NO | 13/232776 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502738 (20130101) B01L 2300/0816 (20130101) B01L 2300/1827 (20130101) B01L 2300/1861 (20130101) B01L 2400/0406 (20130101) B01L 2400/0442 (20130101) B01L 2400/0677 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/004 (20130101) F16K 99/0032 (20130101) F16K 2099/0084 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/49 (20130101) G01N 33/86 (20130101) Original (OR) Class G01N 2035/00247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846551 | Gupta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Mool C. Gupta (Yorktown, Virginia); Barada K. Nayak (Charlottesville, Virginia) |
| ABSTRACT | The surface of a material is textured and by exposing the surface to pulses from an ultrafast laser. The laser treatment causes pillars to form on the treated surface. These pillars provide for greater light absorption. Texturing and crystallization can be carried out as a single step process. The crystallization of the material provides for higher electric conductivity and changes in optical and electronic properties of the material. The method may be performed in vacuum or a gaseous environment. The gaseous environment may aid in texturing and/or modifying physical and chemical properties of the surfaces. This method may be used on various material surfaces, such as semiconductors, metals and their alloys, ceramics, polymers, glasses, composites, as well as crystalline, nanocrystalline, polycrystalline, microcrystalline, and amorphous phases. |
| FILED | Wednesday, September 26, 2012 |
| APPL NO | 13/628009 |
| ART UNIT | 2891 — Semiconductors/Memory |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/12 (20130101) Original (OR) Class B23K 26/0078 (20130101) B23K 26/0084 (20130101) B23K 26/122 (20130101) B23K 26/127 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/901 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848942 | Radcliffe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eliott Radcliffe (Washington, District of Columbia); Ahmed Naguib (Ann Arbor, Michigan); William M. Humphreys, Jr. (Newport News, Virginia) |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Eliott Radcliffe (Washington, District of Columbia); Ahmed Naguib (Ann Arbor, Michigan); William M. Humphreys, Jr. (Newport News, Virginia) |
| ABSTRACT | A feedback-controlled microphone includes a microphone body and a membrane operatively connected to the body. The membrane is configured to be initially deflected by acoustic pressure such that the initial deflection is characterized by a frequency response. The microphone also includes a sensor configured to detect the frequency response of the initial deflection and generate an output voltage indicative thereof. The microphone additionally includes a compensator in electric communication with the sensor and configured to establish a regulated voltage in response to the output voltage. Furthermore, the microphone includes an actuator in electric communication with the compensator, wherein the actuator is configured to secondarily deflect the membrane in opposition to the initial deflection such that the frequency response is adjusted. An acoustic beam forming microphone array including a plurality of the above feedback-controlled microphones is also disclosed. |
| FILED | Tuesday, September 13, 2011 |
| APPL NO | 13/231386 |
| ART UNIT | 2651 — Videophones and Telephonic Communications |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849453 | Bergelin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bryan J Bergelin (Houston, Texas); Chris A. Ihrke (Hartland, Michigan); Donald R. Davis (Novi, Michigan); Douglas Martin Linn (White Lake, Michigan); Lyndon B. J. Bridgwater (Friendswood, Texas) |
| ASSIGNEE(S) | GM Global Technology Operations LLC (Detroit, Michigan); The United States of America as Represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Bryan J Bergelin (Houston, Texas); Chris A. Ihrke (Hartland, Michigan); Donald R. Davis (Novi, Michigan); Douglas Martin Linn (White Lake, Michigan); Lyndon B. J. Bridgwater (Friendswood, Texas) |
| ABSTRACT | A grasp assist system includes a glove, actuator assembly, and controller. The glove includes a digit, i.e., a finger or thumb, and a force sensor. The sensor measures a grasping force applied to an object by an operator wearing the glove. Phalange rings are positioned with respect to the digit. A flexible tendon is connected at one end to one of the rings and is routed through the remaining rings. An exoskeleton positioned with respect to the digit includes hinged interconnecting members each connected to a corresponding ring, and/or a single piece of slotted material. The actuator assembly is connected to another end of the tendon. The controller calculates a tensile force in response to the measured grasping force, and commands the tensile force from the actuator assembly to thereby pull on the tendon. The exoskeleton offloads some of the tensile force from the operator's finger to the glove. |
| FILED | Wednesday, February 29, 2012 |
| APPL NO | 13/408656 |
| ART UNIT | 3651 — Material and Article Handling |
| CURRENT CPC | Data processing: Generic control systems or specific applications 7/250 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849483 | Kuwata et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yoshiaki Kuwata (Los Angeles, California); Michael T. Wolf (Los Angeles, California); Dimitri V. Zarzhitsky (La Canada Flintridge, California); Hrand Aghazarian (La Crescenta, California); Terrance L. Huntsberger (Altadena, California); Andrew B. Howard (Los Angeles, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Yoshiaki Kuwata (Los Angeles, California); Michael T. Wolf (Los Angeles, California); Dimitri V. Zarzhitsky (La Canada Flintridge, California); Hrand Aghazarian (La Crescenta, California); Terrance L. Huntsberger (Altadena, California); Andrew B. Howard (Los Angeles, California) |
| ABSTRACT | Systems and methods for operating autonomous waterborne vessels in a safe manner. The systems include hardware for identifying the locations and motions of other vessels, as well as the locations of stationary objects that represent navigation hazards. By applying a computational method that uses a maritime navigation algorithm for avoiding hazards and obeying COLREGS using Velocity Obstacles to the data obtained, the autonomous vessel computes a safe and effective path to be followed in order to accomplish a desired navigational end result, while operating in a manner so as to avoid hazards and to maintain compliance with standard navigational procedures defined by international agreement. The systems and methods have been successfully demonstrated on water with radar and stereo cameras as the perception sensors, and integrated with a higher level planner for trailing a maneuvering target. |
| FILED | Friday, April 13, 2012 |
| APPL NO | 13/446899 |
| ART UNIT | 3668 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 1/00 (20130101) G05D 1/02 (20130101) G05D 1/0206 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 08846055 | Borca et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Manuel V. Borca (Westbrook, Connecticut); Guillermo R. Risatti (Westbrook, Connecticut) |
| ASSIGNEE(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Manuel V. Borca (Westbrook, Connecticut); Guillermo R. Risatti (Westbrook, Connecticut) |
| ABSTRACT | Classical Swine Fever Virus (CSFV) E2 glycoprotein is a major inducer of neutralizing antibodies and protective immunity in swine. E2 mediates virus adsorption to the target cell, and harbors genetic determinants associated with virus virulence. CSFV E2 also contains between residues 829 and 837 a discrete epitope (TAVSPTTLR) recognized by monoclonal antibody (mAb) WH303, used to differentiate CSFV from related Pestiviruses Bovine Viral Diarrhea Virus (BVDV) and Border Disease Virus (BDV). In this report, a CSFV infectious clone of the virulent Brescia isolate (BICv) was used to progressively mutate the mAb WH303 epitope of CSFV E2 to the homologous amino acid sequence of BVDV strain NADL E2 (TSFNMDTLA). While the resulting virus mutants T1v (TSFSPTTLR), T2v (TSFNPTTLR), T3v (TSFNMTTLR) demonstrated in vitro growth characteristics similar to those of parental BICv, mutants T4v (TSFNMDTLR) and T5v (TSFNMDTLA) exhibited a 10-fold decrease in virus yield and a significant decrease in plaque size relative to parental BICv. Immunohistochemical reactivity with WH303 was lost only in T3v, T4v and T5v. Interestingly, progressive mutation of the WH303 epitope had an additive effect on attenuation for the virus in swine, with mutants T1v, T2v or T3v inducing progressively milder but invariably lethal CSF, T4v inducing only mild and transient clinical disease, and T5v inducing no disease. Swine infected with either T4v or T5v showed decreased virus replication in tonsils, draining lymph node, spleen and kidney and a significant reduction in virus shedding. Finally, T5v-infected animals were protected from clinical disease when challenged with virulent Brescia virus at 3 or 21 days post T5v inoculation. These results indicate that amino acid residues 830 to 834 of E2 are critical for virulence of CSFV in swine and that engineering at this locus may provide basis for a rationally designed live attenuated CSF vaccine. |
| FILED | Tuesday, May 30, 2006 |
| APPL NO | 11/443132 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24322 (20130101) C12N 2770/24361 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846057 | De Los Santos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Teresa B. De Los Santos (Miller Place, New York); James J. Zhu (Niantic, Connecticut); Fayna Diaz-San Segundo (Ronkonkoma, New York); Marvin J. Grubman (Southold, New York); Marla J. Koster (Cutchogue, New York) |
| ASSIGNEE(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Teresa B. De Los Santos (Miller Place, New York); James J. Zhu (Niantic, Connecticut); Fayna Diaz-San Segundo (Ronkonkoma, New York); Marvin J. Grubman (Southold, New York); Marla J. Koster (Cutchogue, New York) |
| ABSTRACT | Previously we have identified a conserved domain (SAP, for SAF-A/B, Acinus, and PIAS) in the foot-and-mouth disease virus (FMDV) leader (L) protein coding region that is required for proper sub-cellular localization and function. Mutation of isoleucine 55 and leucine 58 to alanine (I55A, L58A) within the SAP domain resulted in a viable virus that displayed a mild attenuated phenotype in cell culture, along with altered sub-cellular distribution of L and failure to induce degradation of the transcription factor nuclear factor kappa-B. Here we report that inoculation of swine and cattle with this mutant virus results in the absence of clinical disease, the induction of a significant FMDV-specific neutralizing antibody response, and protection against subsequent homologous virus challenge. Remarkably, swine vaccinated with SAP mutant virus are protected against wild type virus challenge as early as two days post-vaccination suggesting that a strong innate as well as adaptive immunity is elicited. This variant could serve as the basis for construction of a live-attenuated FMD vaccine candidate. |
| FILED | Wednesday, January 19, 2011 |
| APPL NO | 13/009211 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/522 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/32134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846349 | Burns |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Frank R. Burns (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | E.I. du Pont de Nemours and Company (Wilmington, Delaware) |
| INVENTOR(S) | Frank R. Burns (Philadelphia, Pennsylvania) |
| ABSTRACT | This invention relates to a rapid method for detection and characterization of Escherichia coli bacteria serotype O157:H7 based on the presence of nucleic acid sequences, in particular, to a PCR-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. This method is preferably employed to detect E. coli O157:H7 in a food or water sample, such as a beef enrichment. The present invention further relates to replication compositions and kits for carrying out the method of the present invention. |
| FILED | Tuesday, July 20, 2010 |
| APPL NO | 12/839837 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/91.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846372 | Eckstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Torsten Manfred Eckstein (Fort Collins, Colorado); Julia Mitsue Inamine Eckstein (Fort Collins, Colorado) |
| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| INVENTOR(S) | Torsten Manfred Eckstein (Fort Collins, Colorado); Julia Mitsue Inamine Eckstein (Fort Collins, Colorado) |
| ABSTRACT | The use of free, extractable lipids found in bacteria for identification of bacterial species and subspecies is described. Bacteria have been found to differ sufficiently in their extracted lipid compositions to effect identification using thin layer chromatographic techniques. Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei have been distinguished in this manner. Lipopeptides specific to Mycobacterium avium subspecies paratuberculosis, but not to the closely related bacterium Mycobacterium avium subspecies avium have also been used as a basis for bacterial subspecies identification using mass spectrometry and seroreactivity. Mass spectrometric analysis of total bacterial lipids of Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei, and mass spectrometric analysis of total bacterial lipids for Mycobacterium avium subspecies paratuberculosis and Mycobacterium avium subspecies avium, without further lipid separation, has shown that species and subspecies of bacteria may be identified using such analysis. |
| FILED | Thursday, December 02, 2010 |
| APPL NO | 12/959248 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/253.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US PP24933 | Ledbetter |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Craig A Ledbetter (Clovis, California) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Craig A Ledbetter (Clovis, California) |
| ABSTRACT | A new and distinct variety of apricot (Prunus armeniaca L.) named ‘Twocot’, particularly characterized by its white flesh of medium-sized fruit; upright trees with self-incompatible flowers; consistent fruit productivity during early June in California's Central San Joaquin Valley; aromatic fruit with balanced levels of sugar and fruit acid; and a late bloom interval. |
| FILED | Wednesday, May 16, 2012 |
| APPL NO | 13/506771 |
| ART UNIT | 1661 — Plants |
| CURRENT CPC | Plants PLT/186 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 08846077 | Dewitt |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bind Biosciences, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Bind Biosciences, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | David M. Dewitt (Allston, Massachusetts) |
| ABSTRACT | This application provides a high throughput method of making nanoparticles that utilizes plates comprising wells (e.g., 96-well plates). |
| FILED | Monday, December 17, 2012 |
| APPL NO | 13/716275 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 3/00 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 9/5153 (20130101) A61K 9/5192 (20130101) A61K 47/48969 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846195 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Frank Y. Xu (Round Rock, Texas); Edward Brian Fletcher (Austin, Texas) |
| ASSIGNEE(S) | Canon Nanotechnologies, Inc. (Austin, Texas); Molecular Imprints, Inc. (Austin, Texas) |
| INVENTOR(S) | Frank Y. Xu (Round Rock, Texas); Edward Brian Fletcher (Austin, Texas) |
| ABSTRACT | An imprint lithography imprinting stack includes a substrate and a polymeric adhesion layer adhered to the substrate. The polymeric adhesion layer includes polymeric components with an extended backbone length of at least about 2 nm. The backbones of the polymeric components may be substantially aligned in a planar configuration on the surface of the substrate, such that a thickness of the polymeric adhesion layer is less than about 2 nm. |
| FILED | Tuesday, December 02, 2008 |
| APPL NO | 12/326709 |
| ART UNIT | 1765 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 30/00 (20130101) B82Y 40/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class G03F 7/0388 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08848315 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | XiaoMin Yang (Sewickley, Pennsylvania); Shuaigang Xiao (Pittsburgh, Pennsylvania); Jie Gong (Eden Prairie, Minnesota); Michael Seigler (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Seagate Technology LLC (Cupertino, California) |
| INVENTOR(S) | XiaoMin Yang (Sewickley, Pennsylvania); Shuaigang Xiao (Pittsburgh, Pennsylvania); Jie Gong (Eden Prairie, Minnesota); Michael Seigler (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method for forming a magnetic write pole with a trapezoidal cross-section is described. The method consists of first forming a magnetic seedlayer on a base followed by depositing a removable material layer on the seedlayer, and then a resist layer on the removable material layer. A trench is then formed in the resist, and the resist is heated to cause the cross -sectional profile of the trench to assume a trapezoidal shape. The resist is then capped with another resist layer and further heated to cause the width of the trapezoidal trench to become narrower. The cap layer and removable material layer at the bottom of the trench are then removed and the trench filled with magnetic material by electroplating. The resist and seedlayer external to the trench are finally removed to form a write pole with a trapezoidal cross-section. |
| FILED | Tuesday, September 04, 2012 |
| APPL NO | 13/602915 |
| ART UNIT | 2686 — Optics |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/10 (20130101) C25D 5/14 (20130101) Information Storage Based on Relative Movement Between Record Carrier and Transducer G11B 5/1278 (20130101) G11B 5/3116 (20130101) G11B 5/3163 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 08849475 | Sudolsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael D. Sudolsky (Huntington Beach, California); Kirby Keller (Chesterfield, Missouri); Bradley J. Mitchell (Snohomish, Washington) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Michael D. Sudolsky (Huntington Beach, California); Kirby Keller (Chesterfield, Missouri); Bradley J. Mitchell (Snohomish, Washington) |
| ABSTRACT | A system and method for sensor management is provided. The system includes a plurality of sensors, and a sensor controller node communicatively coupled to the plurality of sensors, said sensor controller node configured to dynamically task data collections and communications with at least one of the plurality of sensors. |
| FILED | Wednesday, April 04, 2012 |
| APPL NO | 13/439162 |
| ART UNIT | 3661 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Data processing: Vehicles, navigation, and relative location 71/3 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Geospatial Intelligence Agency (NGA)
| US 08846266 | Scott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Daniel Marin Scott (Laie, Hawaii); BorYann Liaw (Honolulu, Hawaii) |
| ASSIGNEE(S) | University of Hawaii (Honolulu, Hawaii) |
| INVENTOR(S) | Daniel Marin Scott (Laie, Hawaii); BorYann Liaw (Honolulu, Hawaii) |
| ABSTRACT | Abiotic fuel cell and battery designs employing chemical dyes in alkaline solutions are disclosed. The fuel cells and batteries are capable of harnessing electrical power from various carbohydrates, including, but not limited to, glucose; in an anode design that does not require catalysts or membranes to separate half-cell reaction chambers. In certain embodiments, the abiotic fuel cell or battery designs may further employ electrodes, such as high surface area carbon materials and commercial air breathing electrodes, without the use of catalysts for glucose oxidation (i.e., precious metals or biocatalytic species). In further embodiments, organic dyes, including but not limited to, methyl viologen (MV), methylene blue, methylene green, Meldola's blue, indigo carmine, safranin O, and the like, may serve as the electron mediators. In some embodiments, the fuel cells or batteries are capable of generating power on the order of about tens of mW/cm2 from glucose and/or other types of sugars. |
| FILED | Wednesday, April 28, 2010 |
| APPL NO | 12/769598 |
| ART UNIT | 1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/96 (20130101) H01M 8/083 (20130101) Original (OR) Class H01M 2300/0014 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 08846365 | Frommer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wolf B. Frommer (Stanford, California); Hong Gu (Zhejiang, China PRC); Sylvie Lalonde (Stanford, California); Arthur Grossman (Stanford, California) |
| ASSIGNEE(S) | Carnegie Institution of Washington (Washington, District of Columbia) |
| INVENTOR(S) | Wolf B. Frommer (Stanford, California); Hong Gu (Zhejiang, China PRC); Sylvie Lalonde (Stanford, California); Arthur Grossman (Stanford, California) |
| ABSTRACT | Phosphate biosensors are disclosed, which comprise a phosphate binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon phosphate binding. Such biosensors are useful for real time monitoring of phosphate metabolism in living cells. |
| FILED | Friday, October 14, 2005 |
| APPL NO | 12/083267 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 14/195 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 08845523 | Lawrence et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dale A. Lawrence (Louisville, Colorado); Sutha Aphanuphong (Boulder, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Dale A. Lawrence (Louisville, Colorado); Sutha Aphanuphong (Boulder, Colorado) |
| ABSTRACT | There is disclosed a MicroFlex Scope (MFS). The MFS is a dexterous endoscope providing access, direct visualization, tissue sampling, and treatment, of body lumens. In one embodiment, the distal end of the MFS is an ultra-flexible tip that comprises a plurality of thin, curved shape memory alloy (SMA) actuator elements attached to at least one structural skeleton, a coil spring skeleton or hinge structure. The SMA actuator elements in each structural skeleton segment are indirectly heated by a heater element and produce force in response to their temperature relative to specific thresholds. In configurations comprising a plurality of actuator elements, multiplexing/demultiplexing of heating currents and sensor voltages may be accomplished via a parallel bus and demultiplexing circuit. In this regard, a demultiplexing circuit using standard microelectronic fabrication techniques may be designed to achieve individual sensing and control over each actuator element. |
| FILED | Friday, December 23, 2011 |
| APPL NO | 13/336726 |
| ART UNIT | 3779 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/012 (20130101) A61B 1/2676 (20130101) Original (OR) Class A61B 2017/003 (20130101) A61B 2017/00398 (20130101) A61B 2017/00867 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 08846352 | Chua et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Penelope Chua (San Francisco, California); Aravind Somanchi (Redwood City, California) |
| ASSIGNEE(S) | Solazyme, Inc. (South San Francisco, California) |
| INVENTOR(S) | Penelope Chua (San Francisco, California); Aravind Somanchi (Redwood City, California) |
| ABSTRACT | The invention provides methods of cultivating oil-bearing microbes using xylose as a fixed carbon source. Also provided are microorganisms that have been genetically engineered to metabolize xylose as a fixed carbon source allowing them to convert xylose into oils. Particular advantages of the processes provided herein include production of oils rather than alcohols through the microbial fermentation processes utilizing xylose. |
| FILED | Friday, May 04, 2012 |
| APPL NO | 13/464948 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) C12N 1/22 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/64 (20130101) Original (OR) Class C12P 7/6463 (20130101) C12P 2203/00 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/13 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/678 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 08846032 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jonathan Liu (Milpitas, California); Richard Schwartz (Bethesda, Maryland); Mark Thompson (Morgan Hill, California); Luis Maranga (Santa Clara, California); Mridul Ghosh (San Jose, California); Ajit Subramanian (Berkeley, California); Simon Sheng-Tsiung Hsu (Palo Alto, California) |
| ASSIGNEE(S) | MedImmune, LLC (Gaithersburg, Maryland) |
| INVENTOR(S) | Jonathan Liu (Milpitas, California); Richard Schwartz (Bethesda, Maryland); Mark Thompson (Morgan Hill, California); Luis Maranga (Santa Clara, California); Mridul Ghosh (San Jose, California); Ajit Subramanian (Berkeley, California); Simon Sheng-Tsiung Hsu (Palo Alto, California) |
| ABSTRACT | The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention. |
| FILED | Monday, August 27, 2012 |
| APPL NO | 13/595897 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2760/16151 (20130101) C12N 2760/16152 (20130101) C12N 2760/16251 (20130101) C12N 2760/16252 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846106 | Hoffman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Allan S. Hoffman (Seattle, Washington); Patrick Stayton (Seattle, Washington); Oliver W. Press (Seattle, Washington); Niren Murthy (Atlanta, Georgia); Chantal Lackey Reed (Del Mar, California); Lawrence A. Crum (Bellevue, Washington); Pierre D. Mourad (Seattle, Washington); Tyrone M. Porter (Boston, Massachusetts); David Tirrell (Pasadena, California) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington); University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Allan S. Hoffman (Seattle, Washington); Patrick Stayton (Seattle, Washington); Oliver W. Press (Seattle, Washington); Niren Murthy (Atlanta, Georgia); Chantal Lackey Reed (Del Mar, California); Lawrence A. Crum (Bellevue, Washington); Pierre D. Mourad (Seattle, Washington); Tyrone M. Porter (Boston, Massachusetts); David Tirrell (Pasadena, California) |
| ABSTRACT | Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophoresis can also be used with the disrupting agents. |
| FILED | Thursday, July 14, 2011 |
| APPL NO | 13/182756 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0028 (20130101) A61K 41/0047 (20130101) Original (OR) Class A61K 47/48376 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08846314 | Chambers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robert D. Chambers (Menlo Park, California); Juan G. Santiago (Stanford, California); Alexandre Persat (Palo Alto, California); Reto B. Schoch (Speicherschwendi, Switzerland); Mostafa Ronaghi (Menlo Park, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| INVENTOR(S) | Robert D. Chambers (Menlo Park, California); Juan G. Santiago (Stanford, California); Alexandre Persat (Palo Alto, California); Reto B. Schoch (Speicherschwendi, Switzerland); Mostafa Ronaghi (Menlo Park, California) |
| ABSTRACT | A method and system are presented for fast and efficient isolation, purification and quantitation of nucleic acids from complex biological samples using isotachophoresis in microchannels. In an embodiment, a sieving medium may be used to enhance selectivity. In another embodiment, PCR-friendly chemistries are used to purify nucleic acids from complex biological samples and yield nucleic acids ready for further analysis including for PCR. In another embodiment, small RNAs from biological samples are extracted, isolated, preconcentrated and quantitated using on-chip ITP with a high efficiency sieving medium. The invention enables fast concentration and separation (takes 10s to 100s of seconds) of nucleic acids with high selectivity and using lower volumes of reagents (order of 10s of μL to focus less than 1 pg/μL of nucleic acid). |
| FILED | Tuesday, March 02, 2010 |
| APPL NO | 12/716142 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Separation B01D 57/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08847202 | Nosho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brett Z. Nosho (Santa Monica, California); Rajesh D. Rajavel (Oak Park, California); Hasan Sharifi (Agoura Hills, California); Sevag Terterian (Van Nuys, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Brett Z. Nosho (Santa Monica, California); Rajesh D. Rajavel (Oak Park, California); Hasan Sharifi (Agoura Hills, California); Sevag Terterian (Van Nuys, California) |
| ABSTRACT | A dual-band infrared detector structure based on Type-II superlattices (T2SL) has been developed and experimentally validated. The structure according to the principles of the present invention is designed for a single Indium bump architecture and utilizes a T2SL barrier design that omits the traditional p-n junction region. The barrier design comprises multiple periods where each period comprises multiple monolayers doped P type. By selecting the composition, number of monolayers per period and number of periods, a transition region is created in the conduction band between a first absorber layer and a second absorber layer that allows operation at low biases (<100 mV for both bands) and exhibits a dark current density in the longer wavelength band comparable to that obtained with single-color detectors. |
| FILED | Tuesday, January 17, 2012 |
| APPL NO | 13/351997 |
| ART UNIT | 2898 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/11 (20130101) H01L 31/065 (20130101) H01L 31/109 (20130101) H01L 31/02016 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 08849728 | Ebert et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David S. Ebert (West Lafayette, Indiana); Timothy Collins (Brookston, Indiana); Ross Maciejewski (West Lafayette, Indiana); Abish Malik (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | David S. Ebert (West Lafayette, Indiana); Timothy Collins (Brookston, Indiana); Ross Maciejewski (West Lafayette, Indiana); Abish Malik (West Lafayette, Indiana) |
| ABSTRACT | A system and method for visually displaying and analyzing criminal and/or public health and safety data for geospatial and/or time variations, including the collection of incident data coupled with geographic and time data, filtering the symptom data based upon a selected time period and geographic range, and creating a visual result based upon statistical modeling including power transform and/or data normalization. According to at least one embodiment, the system for visually displaying and analyzing includes selecting and performing at least one aberration detection method and displaying the result to a user via a visual analytics arrangement. |
| FILED | Tuesday, November 08, 2011 |
| APPL NO | 13/291761 |
| ART UNIT | 2129 — AI & Simulation/Modeling |
| CURRENT CPC | Electric Digital Data Processing G06F 19/3493 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, September 30, 2014.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2014/fedinvent-patents-20140930.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page