FedInvent™ Patents

Patent Details for Tuesday, May 15, 2018

This page was updated on Monday, March 27, 2023 at 05:32 AM GMT

Department of Health and Human Services (HHS)

09968261 — Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging

US 09968261	Motafakker-Fard et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Ali Motafakker-Fard (Revere, Massachusetts); Paulino Vacas Jacques (Boston, Massachusetts); Guillermo Tearney (Cambridge, Massachusetts); Mireille Rosenberg (Brookline, Massachusetts)
ABSTRACT	An apparatus can be provided according to certain exemplary embodiments. For example, the apparatus can include a waveguiding first arrangement providing at least one electromagnetic radiation. A configuration can be provided that receives and splits the at least one electromagnetic radiation into a first radiation and a second radiation. The apparatus can further include a waveguiding second arrangement which has a first waveguide and a second waveguide, whereas the first waveguide receives the first radiation, and the second waveguide receives the second radiation. The first arrangement, the second arrangement and the configuration can be housed in a probe.
FILED	Tuesday, January 28, 2014
APPL NO	14/165827
ART UNIT	3737 — SELECT * FROM codes_techcenter;
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/07 (20130101) A61B 5/0066 (20130101) A61B 5/0075 (20130101) A61B 5/0084 (20130101) Original (OR) Class A61B 2562/0233 (20130101) A61B 2576/00 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02091 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/55 (20130101) G01N 21/474 (20130101) G01N 21/4795 (20130101) G01N 2021/4757 (20130101) G01N 2021/4761 (20130101)
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09968280 — Method for insertion of a medical device within a body during a medical imaging process

US 09968280	Whitcomb et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Louis L. Whitcomb (Baltimore, Maryland); Axel Krieger (Alexandria, Virginia); Robert C. Susil (Baltimore, Maryland); Gabor Fichtinger (Bethesda, Maryland); Ergin Atalar (Bilkent Ankara, Turkey); Iulian I. Iordachita (Lutherville, Maryland)
ABSTRACT	A method for tracking movement of a movable portion of an interventional device disposed within a natural or artificial body opening is provided. In particular, image data of fiducials is acquired and therefrom an initial position of an interventional device movable portion with respect to a given coordinate system is determined. Next, real time position data from the encoders is acquired as the movable portion is moved from the initial position, and a displaced position from the initial position is determined. From this acquired information, a position of the movable portion in the coordinate system is determined using both the initial position as determined from the image data and the real time displaced position as determined from the encoders.
FILED	Tuesday, July 23, 2013
APPL NO	13/948614
ART UNIT	3737 — SELECT * FROM codes_techcenter;
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/064 (20130101) Original (OR) Class A61B 6/12 (20130101) A61B 8/12 (20130101) A61B 10/0241 (20130101) A61B 34/20 (20160201) A61B 34/25 (20160201) A61B 34/30 (20160201) A61B 90/11 (20160201) A61B 90/50 (20160201) A61B 2017/00911 (20130101) A61B 2090/374 (20160201) A61B 2090/376 (20160201) A61B 2090/378 (20160201)
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09968557 — Method of preparing modified multilayered microstructures with enhanced oral bioavailability

US 09968557	Sachdeva et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR)
APPLICANT(S)	Florida A and M University (Tallahassee, Florida)
ASSIGNEE(S)	Florida A and M University (Tallahassee, Florida)
INVENTOR(S)	Mandip Sachdeva (Tallahassee, Florida); Apurva Patel (Longwood, Florida)
ABSTRACT	A dual channel spray gun, and method of use thereof, for fabricating nanostructures including a pharmaceutical/therapeutic agent having enhanced oral bioavailability. The nanostructures are a mixture of at least two (2) solutions/media substantially equally distributed as desired. The spray gun device uses gas pressure and/or two ultrasonicators to simultaneously prepare two solution systems for subsequent mixture and atomization. The gas pressure and frequencies of the ultrasonicators are adjustable for each channel of the spray gun. In operation, the spray gun is used to prepare microstructures that, for example, contain at least one active pharmaceutical agent in one solution system and excipients, such as coating or bioadhesives, in the other solution system. Any combination of solution systems is contemplated, such as both systems containing a pharmaceutical agent or both systems containing excipients.
FILED	Wednesday, February 17, 2016
APPL NO	15/046087
ART UNIT	3752 — Fluid Handling and Dispensing
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/167 (20130101) A61K 9/1617 (20130101) A61K 9/1682 (20130101) Original (OR) Class A61K 31/404 (20130101)
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09968569 — Adjuvant chemotherapy for anaplastic gliomas

US 09968569	Towner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR)
APPLICANT(S)	OKLAHOMA MEDICAL RESEARCH FOUNDATION (Oklahoma City, Oklahoma)
ASSIGNEE(S)	OKLAHOMA MEDICAL RESEARCH FOUNDATION (Oklahoma City, Oklahoma)
INVENTOR(S)	Rheal A. Towner (Piedmont, Oklahoma); Robert A. Floyd (Oklahoma City, Oklahoma)
ABSTRACT	The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.
FILED	Thursday, October 13, 2016
APPL NO	15/292324
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/10 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 31/15 (20130101) Original (OR) Class A61K 31/166 (20130101) A61K 31/175 (20130101) A61K 31/185 (20130101) A61K 31/185 (20130101) A61K 31/4748 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101)
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09968577 — Treatment and prevention of bone loss using resolvins

US 09968577	Van Dyke
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Forsyth Dental Infirmary for Children (Cambridge, Massachusetts)
ASSIGNEE(S)	Forsyth Dental Infirmary for Children (Cambridge, Massachusetts)
INVENTOR(S)	Thomas E. Van Dyke (West Roxbury, Massachusetts)
ABSTRACT	The invention provides new methods for inducing or promoting bone growth and/or for reducing or preventing bone deterioration in a mammal subject. The inventive methods generally comprise administering to the subject an effective amount of a resolving. In particular, the inventive methods may be useful for treating or preventing conditions associated with bone degradation, deterioration or degeneration such as periodontal disease, osteoarthritis, and metastatic bone disease and osteolytic bone disease. Pharmaceutical compositions and kits comprising at least one resolving are also provided that can be used to performed the inventive methods.
FILED	Thursday, December 19, 2013
APPL NO	14/134627
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/22 (20130101) A61K 31/22 (20130101) A61K 31/202 (20130101) Original (OR) Class A61K 31/202 (20130101) A61K 31/557 (20130101) A61K 31/557 (20130101) A61K 31/663 (20130101) A61K 31/663 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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09968579 — ATRA for modulating Pin1 activity and stability

US 09968579	Lu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI) National Institute on Aging (NIA) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Beth Isreal Deaconess Medical Center, Inc. (Boston, Massachusetts)
INVENTOR(S)	Kun Ping Lu (Newton, Massachusetts); Xiao Zhen Zhou (Newton, Massachusetts); Shuo Wei (Chestnut Hill, Massachusetts)
ABSTRACT	The present disclosure describes how all-retinoic acid (ATRA) binds and inhibits Pin1 activity and induces degradation of the activated Pin1 monomer selectively in cancer cells. Identification of the binding mechanism of ATRA with Pin1 confirm ATRA binding specificity to Pin1 residues in the PPIase active site, thus demonstrating that drug-induced Pin1 ablation has potent anticancer activity, such as in acute promyelocytic leukemia (APL), by inducing PML-RARa degradation, as well as against other types of cancer and diseases that are associated with Pin1 overexpression, such as aggressive triple negative breast cancer, lupus, asthma, cocaine addiction, among others, due to their unique ability to simultaneously block numerous cancer-driving pathways, with relatively lower toxicity. The present disclosure also provides a rationale for developing sustained released ATRA-containing formulations. ATRA-containing formulations may be used in combinations with other existing therapies including chemotherapy or molecularly targeted drugs and other standard of care.
FILED	Thursday, July 16, 2015
APPL NO	15/326979
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) A61K 31/192 (20130101) A61K 31/203 (20130101) Original (OR) Class A61K 31/353 (20130101) A61K 31/428 (20130101) A61K 45/06 (20130101)
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09968587 — Heterocycle analogs of CAI-1 as agonists of quorum sensing in vibrio

US 09968587	Bassler et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
INVENTOR(S)	Bonnie L. Bassler (Princeton, New Jersey); Lark J. Perez (Ewing, New Jersey); Martin F. Semmelhack (Princeton, New Jersey)
ABSTRACT	A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae. Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.
FILED	Tuesday, August 19, 2014
APPL NO	14/912207
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/36 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/53 (20130101) A61K 31/401 (20130101) Original (OR) Class A61K 31/401 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 207/333 (20130101)
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09968599 — Platinum compounds that inhibit constitutive STAT3 signaling and induce cell cycle arrest and apoptosis of malignant cells

US 09968599	Sebti et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
ASSIGNEE(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
INVENTOR(S)	Said M. Sebti (Tampa, Florida); Nicholas J. Lawrence (Tampa, Florida); James Turkson (Honolulu, Hawaii)
ABSTRACT	The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention.
FILED	Friday, November 20, 2015
APPL NO	14/947786
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) Original (OR) Class A61K 33/24 (20130101) Heterocyclic Compounds C07D 295/088 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101)
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09968633 — Stimuli responsive compositions for iron chelation

US 09968633	Xiong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	May Pang Xiong (Middleton, Wisconsin); Zhi Liu (Madison, Wisconsin); Yan Wang (Madison, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	May Pang Xiong (Middleton, Wisconsin); Zhi Liu (Madison, Wisconsin); Yan Wang (Madison, Wisconsin)
ABSTRACT	The present technology provides new compositions comprising at least one cross-linked co-polymer. In some embodiments, the polyacrylamide co-polymer comprises water soluble subunits, cross-linking subunits, and iron chelating subunits. In other embodiments, the co-polymer comprises water soluble units, cross-linking subunits, and substituted subunits, which can be conjugated with iron-chelating agents. When these new particles are exposed to certain environments, such the presence of strong acids or oxidation agents, these particles are capable of breaking up so that the iron chelating agents can chelate iron or other metals from their environments. Methods to prepare these new compositions are also provided. These compositions or compositions comprising nanogels of the present technology may be used to treat metal overload conditions such as iron overload resulting from chronic transfusions.
FILED	Tuesday, October 06, 2015
APPL NO	14/876740
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/785 (20130101) Original (OR) Class A61K 47/4823 (20130101) A61K 47/48176 (20130101) A61K 47/48784 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0012 (20130101) C08B 37/0015 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2220/282 (20130101) Compositions of Macromolecular Compounds C08L 5/16 (20130101)
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09968637 — Dopaminergic neurons differentiated from pluripotent stem cells and uses thereof

US 09968637	Cooper et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE MCLEAN HOSPITAL CORPORATION (Belmont, Massachusetts)
ASSIGNEE(S)	THE MCLEAN HOSPITAL CORPORATION (Belmont, Massachusetts)
INVENTOR(S)	Oliver Cooper (Jamaica Plain, Massachusetts); Ole Isacson (Cambridge, Massachusetts)
ABSTRACT	The present invention provides populations of neural cells derived from pluripotent cells, and methods for making and using the same. Disclosed herein are methods for generating dopaminergic neurons in vitro using a combination of agents that cause differentiation of the pluripotent cells into dopaminergic neurons. Also disclosed are methods for treating a neurodegenerative disease in a patient by generating dopaminergic neurons in vitro, and transplanting them into the brain of the patient, such that the dopaminergic neurons are sufficient to reduce or eliminate the symptoms of the neurodegenerative disease.
FILED	Thursday, May 21, 2015
APPL NO	14/718683
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 2500/38 (20130101) C12N 2501/01 (20130101) C12N 2501/13 (20130101) C12N 2501/15 (20130101) C12N 2501/41 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/415 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101)
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09968638 — Compositions and methods for transplantation of colon microbiota

US 09968638	Sadowsky et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Michael J. Sadowsky (St. Paul, Minnesota); Alexander Khoruts (Minneapolis, Minnesota); Alexa R. Weingarden (St. Paul, Minnesota); Matthew J. Hamilton (Minneapolis, Minnesota)
ASSIGNEE(S)	REGENTS OF THE UNIVERSITY OF MINNESOTA (Saint Paul, Minnesota)
INVENTOR(S)	Michael J. Sadowsky (St. Paul, Minnesota); Alexander Khoruts (Minneapolis, Minnesota); Alexa R. Weingarden (St. Paul, Minnesota); Matthew J. Hamilton (Minneapolis, Minnesota)
ABSTRACT	The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
FILED	Friday, March 09, 2012
APPL NO	14/003411
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) A61K 9/0053 (20130101) A61K 9/1617 (20130101) A61K 9/1623 (20130101) A61K 35/24 (20130101) A61K 35/24 (20130101) A61K 35/37 (20130101) Original (OR) Class A61K 35/74 (20130101) A61K 35/74 (20130101) A61K 35/741 (20130101) A61K 35/742 (20130101) A61K 45/06 (20130101) A61K 47/08 (20130101) A61K 47/26 (20130101) A61K 2035/11 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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09968642 — Compositions and methods for treatment of pain

US 09968642	Rudick et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	Charles N. Rudick (Chicago, Illinois); David J. Klumpp (Chicago, Illinois); Anthony J. Schaeffer (Hinsdale, Illinois)
ABSTRACT	The present invention provides compositions and methods for treatment or prevention of pain resulting from infection, infection related pain, and non-infectious pain as well as treatment or prevention of infections or adverse health consequences associated with infections.
FILED	Thursday, December 11, 2014
APPL NO	14/567751
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) Original (OR) Class A61K 2035/115 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 1/19 (20130101)
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09968643 — Selection and use of lactic acid bacteria preventing bone loss in mammals

US 09968643	Connolly et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH)
APPLICANT(S)	BIOGAIA AB (Stockholm, Sweden); Michigan State University (East Lansing, Michigan)
ASSIGNEE(S)	BIOGAIA AB (Stockholm, Sweden); MICHIGAN STATE UNIVERSITY (East Lansing, Michigan)
INVENTOR(S)	Eamonn Connolly (Lidingö, Sweden); Robert Allen Britton (East Lansing, Michigan); Laura Rae McCabe (Haslett, Michigan)
ABSTRACT	The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been selected according to the presented method. The selection method is based on the strain's capability of reestablishing an altered microbial community to normal and/or harboring at least one of four specific SNPs.
FILED	Friday, October 21, 2016
APPL NO	15/331346
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/135 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2002/00 (20130101) A23V 2200/306 (20130101) Indexing Scheme Relating to Lactic or Propionic Acid Bacteria Used in Foodstuffs or Food Preparation A23Y 2220/00 (20130101) A23Y 2220/71 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/747 (20130101) Original (OR) Class A61K 2035/11 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 2600/16 (20130101) C12Q 2600/156 (20130101)
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09968650 — Modified viral structural protein with antiviral activity

US 09968650	Zlotnick et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Adam Zlotnick (Bloomington, Indiana); Dan Loeb (Madison, Wisconsin)
ASSIGNEE(S)	Indiana University Research and Technology Corporation (Indianapolis, Indiana)
INVENTOR(S)	Adam Zlotnick (Bloomington, Indiana); Dan Loeb (Madison, Wisconsin)
ABSTRACT	This disclosure provides a novel strategy to cope with chronic virus infection by introducing a dominant negative viral structural protein to disturb effective virion production. The dominant negative structural protein mimics antiviral drugs through structural and biochemical interactions during virus assembly. An effective gene therapy model for chronic viral infected diseases is proposed in this disclosure, as represented by HBV Cpdominant1 to clear viral infection.
FILED	Friday, July 13, 2012
APPL NO	14/232377
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) A01K 2207/05 (20130101) A01K 2267/0337 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/162 (20130101) Original (OR) Class Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2730/10122 (20130101) C12N 2730/10133 (20130101) C12N 2740/16222 (20130101) C12N 2799/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101)
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09968665 — Anti-malaria compositions and methods

US 09968665	Boyd et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	ARTIFICIAL CELL TECHNOLOGIES, INC. (New Haven, Connecticut)
ASSIGNEE(S)	ARTIFICIAL CELL TECHNOLOGIES, INC. (New Haven, Connecticut)
INVENTOR(S)	James Gorham Boyd (Madison, Connecticut); Thomas J. Powell (Madison, Connecticut)
ABSTRACT	Described herein are multilayer films that include modified polypeptide epitopes from Plasmodium falciparum, specifically a modified T* epitope. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes the modified T* polypeptide epitope from a Plasmodium protozoan.
FILED	Tuesday, September 13, 2016
APPL NO	15/264035
ART UNIT	1675 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class Peptides C07K 7/08 (20130101)
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09968667 — Targets and compositions for use in decontamination, immunoprophylaxis, and post-exposure therapy against anthrax

US 09968667	Huang et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Altimmune Inc. (Gaithersburg, Maryland)
ASSIGNEE(S)	Altimmune Inc. (Gaithersburg, Maryland)
INVENTOR(S)	Chun-Ming Huang (Gaithersburg, Maryland); JianFeng Zhang (Gaithersburg, Maryland); De-Chu Tang (Gaithersburg, Maryland)
ABSTRACT	The present invention relates to the decontamination of anthrax spores, prophylaxis and treatment of anthrax infections and, more particularly, to compounds that act as specific inhibitors of B. anthracis germination/outgrowth-associated proteins, methods and means for making such inhibitors and their use as pharmaceuticals and/or vaccines. The invention also relates to the prophylaxis and treatment of anthrax infections and, more particularly, to vaccines and compositions that comprise B. anthracis antigens, epitopes, proteins, or nucleic acid molecules, including anthrax protective antigen, anthrax lethal factor, anthrax edema factor and anthrax proteins associated with spore germination and outgrowth, as well as methods and means for making such compositions and their use pharmaceuticals and/or vaccines.
FILED	Wednesday, September 30, 2015
APPL NO	14/870570
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/07 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/57 (20130101) A61K 2039/523 (20130101) A61K 2039/543 (20130101) A61K 2039/552 (20130101) A61K 2039/5256 (20130101) Peptides C07K 14/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10043 (20130101)
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09968668 — Staphylococcal coagulase antigens and methods of their use

US 09968668	McAdow et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	UNIVERSITY OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)	The University of Chicago (Chicago, Illinois)
INVENTOR(S)	Molly McAdow (Chicago, Illinois); Andrea Dedent (Chicaco, Illinois); Alice Cheng (Chicago, Illinois); Carla Emolo (Chicago, Illinois); Dominique Missiakas (Chicago, Illinois); Olaf Schneewind (Chicago, Illinois)
ABSTRACT	The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.
FILED	Thursday, March 14, 2013
APPL NO	14/397031
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/48 (20130101) A61K 39/085 (20130101) Original (OR) Class A61K 45/06 (20130101) Peptides C07K 14/31 (20130101) C07K 16/1271 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101)
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09968670 — Influenza virus vaccines and uses thereof

US 09968670	Garcia-Sastre et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Icahn School of Medicine at Mount Sinai (New York, New York)
ASSIGNEE(S)	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York)
INVENTOR(S)	Adolfo Garcia-Sastre (New York, New York); Peter Palese (New York, New York); Florian Krammer (New York, New York)
ABSTRACT	Provided herein are chimeric influenza hemagglutinin (HA) polypeptides, compositions comprising the same, vaccines comprising the same, and methods of their use.
FILED	Tuesday, December 17, 2013
APPL NO	14/652643
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/54 (20130101) A61K 2039/55 (20130101) A61K 2039/70 (20130101) A61K 2039/521 (20130101) A61K 2039/543 (20130101) A61K 2039/545 (20130101) A61K 2039/5252 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16123 (20130101) C12N 2760/16134 (20130101) C12N 2760/16223 (20130101) C12N 2760/16234 (20130101)
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09968689 — AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells

US 09968689	Pan
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Wayne State University (Detroit, Michigan)
ASSIGNEE(S)	WAYNE STATE UNIVERSITY (Detroit, Michigan)
INVENTOR(S)	Zhuo-Hua Pan (Troy, Michigan)
ABSTRACT	Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are expressed in retinal ganglion cells upon transduction using recombinant AAV vectors. Selective targeting of these transgenes for expression in discrete subcellular regions or sites is achieved by including a sorting motif in the vector that can target either the central area or surround (off-center) area of these cells. Nucleic acid molecules comprising nucleotide sequences encoding such rhodopsins and sorting motifs and their use in methods of differential expression of the transgene are disclosed. These compositions and methods provide significant improvements for restoring visual perception and various aspects of vision, particular in patients with retinal disease.
FILED	Friday, August 12, 2016
APPL NO	15/236152
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 48/005 (20130101) Original (OR) Class Peptides C07K 14/705 (20130101) C07K 14/4702 (20130101) C07K 2319/01 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8616 (20130101) C12N 2750/14143 (20130101)
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09968693 — Small molecule imaging of fungi by positron emission tomography scanning

US 09968693	Williamson et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); The Research Foundation of the State University of New York (Amherst, New York)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); The Research Foundation of the State University of New York (Amherst, New York)
INVENTOR(S)	Peter R. Williamson (Bethesda, Maryland); Dale O. Kiesewetter (Gaithersburg, Maryland); John Panepinto (Buffalo, New York); Jin Qiu (Bethesda, Maryland)
ABSTRACT	Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of wherein R¹is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R²is —NHC(O)—R³—L or —C(O)NH—R³—L, wherein R³is an aryl or an aliphatic group (such as alkyl); each R⁴independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R⁵independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R⁴; each n independently is 1, 2, 3, 4, or 5; and L is ¹⁸F or a chelator capable of chelating a radiolabel (such as chelators for [¹⁸F]AlF, ⁶⁴Cu, ⁶⁸Ga),1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).
FILED	Thursday, October 23, 2014
APPL NO	15/030554
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 51/0461 (20130101) Original (OR) Class General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) Heterocyclic Compounds C07D 251/68 (20130101)
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09968714 — Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions

US 09968714	Fujimoto et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Kazuro Lee Fujimoto (Pittsburgh, Pennsylvania); Jianjun Guan (Pittsburgh, Pennsylvania); Bradley B. Keller (Pittsburgh, Pennsylvania); Kimimasa Tobita (Wexford, Pennsylvania); William R. Wagner (Gibsonia, Pennsylvania)
ABSTRACT	Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.
FILED	Thursday, January 15, 2015
APPL NO	14/597520
ART UNIT	3731 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/7007 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) Original (OR) Class
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09968726 — Methods for implanting subcutaneous vascular access ports

US 09968726	Phillips et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	DF Vital Holdings, LLC (Wilmington, Delaware)
ASSIGNEE(S)	DF Vital Holdings, LLC (Wilmington, Delaware)
INVENTOR(S)	Christopher M. Phillips (Salt Lake City, Utah); Nathaniel P. Young (Salt Lake City, Utah); Trent J. Perry (Kaysville, Utah); Duane D. Blatter (Salt Lake City, Utah); Mark A. Crawford (Sandy, Utah); G. Doug Smith (Sandy, Utah); Steven Johnson (Lehi, Utah)
ABSTRACT	A method of securing an access port to a vessel can include positioning an access port adjacent to a wall of the vessel. The access port can include an implantation passageway and a guidance passageway that is connected to the implantation passageway. The implantation passageway can be open, during the positioning of the access port, at a position proximal to a location at which the implantation passageway and the guidance passageway are connected. The method can further include forming an opening in the wall of the vessel via instruments that extend through the implantation passageway. The method can include securing the access port to the vessel such that the implantation passageway is in fluid communication with an interior of the vessel via the opening in the wall of the vessel. The method can also include sealing the implantation passageway at the position proximal to the guidance passageway.
FILED	Monday, July 06, 2015
APPL NO	14/792486
ART UNIT	3761 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/0057 (20130101) A61B 17/3423 (20130101) A61B 2017/00641 (20130101) A61B 2017/00654 (20130101) A61B 2017/3425 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/3653 (20130101) Original (OR) Class A61M 1/3659 (20140204) A61M 1/3661 (20140204) A61M 39/0208 (20130101) A61M 2039/0223 (20130101) A61M 2039/0226 (20130101) A61M 2039/0238 (20130101) A61M 2205/0238 (20130101)
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09968901 — Methods of sample preparation

US 09968901	Head et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Steven Robert Head (La Jolla, California); Phillip T. Ordoukhanian (La Jolla, California); Daniel R. Salomon (La Jolla, California)
ASSIGNEE(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S)	Steven Robert Head (La Jolla, California); Phillip T. Ordoukhanian (La Jolla, California); Daniel R. Salomon (La Jolla, California)
ABSTRACT	The present disclosure provides methods, compositions, and kits for methods that can improve techniques nucleic acid analysis, and can allow for more reliable and accurate targeted, multiplexed, high throughput sequencing. The methods, compositions, and kits can be used for sequencing target loci of nucleic acid. The methods, compositions, and kits disclosed herein can be used for assisted de novo targeted sequencing. The methods, compositions, and kits disclosed herein can also be used for library labeling for de novo sequencing and phasing.
FILED	Tuesday, May 21, 2013
APPL NO	14/549411
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class B01J 2219/0059 (20130101) B01J 2219/00709 (20130101) B01J 2219/00722 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) C12Q 1/6874 (20130101) C12Q 2525/161 (20130101) C12Q 2525/191 (20130101) C12Q 2531/125 (20130101) C12Q 2535/122 (20130101) C12Q 2563/143 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101)
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09968935 — Devices for cell assays

US 09968935	Abbott et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Nicholas Abbott (Madison, Wisconsin); Christopher Murphy (Madison, Wisconsin); Barbara Israel (Mount Horeb, Wisconsin); Josh Sotos (Madison, Wisconsin); Doug Hansmann (Madison, Wisconsin); Renee Herber (Madison, Wisconsin); Joseph Burkholder (Middleton, Wisconsin); Keren Hulkower (Evanston, Illinois); Michael Bonds (Dearfield, Wisconsin)
ASSIGNEE(S)	Platypus Technologies, LLC (Madison, None)
INVENTOR(S)	Nicholas Abbott (Madison, Wisconsin); Christopher Murphy (Madison, Wisconsin); Barbara Israel (Mount Horeb, Wisconsin); Josh Sotos (Madison, Wisconsin); Doug Hansmann (Madison, Wisconsin); Renee Herber (Madison, Wisconsin); Joseph Burkholder (Middleton, Wisconsin); Keren Hulkower (Evanston, Illinois); Michael Bonds (Dearfield, Wisconsin)
ABSTRACT	The present invention relates to the field of molecular diagnostics. In particular, the present invention provided improved substrates and methods of using liquid crystals and other biophotonically based assays for quantitating the amount of an analyte in a sample. The present invention also provides materials and methods for detecting non-specific binding of an analyte to a substrate by using a liquid crystal or other biophotonically based assay formats.
FILED	Wednesday, August 20, 2008
APPL NO	12/195007
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) Original (OR) Class B01L 2200/0668 (20130101) B01L 2300/0829 (20130101) B01L 2300/0851 (20130101)
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09969134 — Nanopatterned biopolymer optical device and method of manufacturing the same

US 09969134	Kaplan et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	David Kaplan (Concord, Massachusetts); Fiorenzo Omenetto (Wakefield, Massachusetts); Brian Lawrence (New York, New York); Mark Cronin-Golomb (Reading, Massachusetts)
ASSIGNEE(S)	Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S)	David Kaplan (Concord, Massachusetts); Fiorenzo Omenetto (Wakefield, Massachusetts); Brian Lawrence (New York, New York); Mark Cronin-Golomb (Reading, Massachusetts)
ABSTRACT	A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film on the substrate, where the solidified biopolymer film is formed with a surface having a nanopattern thereon. In another embodiment, the method also includes annealing the solidified biopolymer film. A nanopatterned biopolymer optical device includes a solidified biopolymer film with a surface having a nanopattern is also provided.
FILED	Monday, November 05, 2007
APPL NO	12/513394
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 1/00 (20130101) C08L 3/00 (20130101) C08L 5/00 (20130101) C08L 89/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) G02B 1/04 (20130101) G02B 1/04 (20130101) G02B 1/04 (20130101) G02B 1/04 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24479 (20150115)
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09969492 — Crop height estimation with unmanned aerial vehicles

US 09969492	Detweiler et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	NUtech Ventures (Lincoln, Nebraska)
ASSIGNEE(S)	NUTECH VENTURES (Lincoln, Nebraska)
INVENTOR(S)	Carrick Detweiler (Lincoln, Nebraska); David Anthony (Lincoln, Nebraska); Sebastian Elbaum (Lincoln, Nebraska)
ABSTRACT	An unmanned aerial vehicle (UAV) can be configured for crop height estimation. In some examples, the UAV includes an aerial propulsion system, a laser scanner configured to face downwards while the UAV is in flight, and a control system. The laser scanner is configured to scan through a two-dimensional scan angle and is characterized by a maximum range. The control system causes the UAV to fly over an agricultural field and maintain, using the aerial propulsion system and the laser scanner, a distance between the UAV and a top of crops in the agricultural field to within a programmed range of distances based on the maximum range of the laser scanner. The control system determines, using range data from the laser scanner, a crop height from the top of the crops to the ground.
FILED	Tuesday, September 06, 2016
APPL NO	15/257441
ART UNIT	3663 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) Original (OR) Class B64C 2201/12 (20130101) B64C 2201/027 (20130101) B64C 2201/123 (20130101) B64C 2201/145 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4808 (20130101) G01S 17/42 (20130101) G01S 17/88 (20130101) G01S 17/89 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0646 (20130101)
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09969677 — Histone acetyltransferase modulators and uses thereof

US 09969677	Francis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Yitshak Francis (New York, New York); Mauro Fa (New York, New York); Ottavio Arancio (New York, New York); Jole Fiorito (New York, New York); Shixian Deng (White Plains, New York); Donald W. Landry (New York, New York); Michal Luzac (New York, New York); Yan Feng (Shanghai, China PRC)
ASSIGNEE(S)	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
INVENTOR(S)	Yitshak Francis (New York, New York); Mauro Fa (New York, New York); Ottavio Arancio (New York, New York); Jole Fiorito (New York, New York); Shixian Deng (White Plains, New York); Donald W. Landry (New York, New York); Michal Luzac (New York, New York); Yan Feng (Shanghai, China PRC)
ABSTRACT	The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
FILED	Thursday, December 22, 2011
APPL NO	13/996483
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 217/22 (20130101) Original (OR) Class Heterocyclic Compounds C07D 209/48 (20130101) C07D 265/14 (20130101) C07D 295/088 (20130101)
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09969681 — DTPA prodrugs, compositions thereof, and methods of using the same

US 09969681	Jay et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S)	Michael Jay (Chapel Hill, North Carolina); Russell Mumper (Watkinsville, Georgia); James Huckle (Chapel Hill, North Carolina); Matthew Sadgrove (Hillsborough, North Carolina)
ABSTRACT	The present invention relates to trisodium diethylenetriamine pentaacetic acid (DTPA) prodrugs, such as, for example, DTPA di-ethyl esters. The invention further relates to compositions comprising DTPA prodrugs and methods of using the same.
FILED	Friday, December 09, 2016
APPL NO	15/374390
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic or Carbocyclic Compounds C07C 227/20 (20130101) C07C 229/26 (20130101) Original (OR) Class Heterocyclic Compounds C07D 265/33 (20130101)
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09969686 — Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them

US 09969686	Tang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Weiping Tang (Middleton, Wisconsin); Xiaoxun Li (Mountain View, California); Dongxu Shu (Lake Bluff, Illinois); Gabrielle N. Winston-McPherson (Madison, Wisconsin)
ABSTRACT	Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, The method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or unsubstituted indol or a substituted or unsubstituted pyrrole, in the presence of a metal-containing catalyst, for a time and at a temperature to cause an annulation/arylation cascade reaction that yields a diindolylmethane or a indolyl/pyrrolylmethane. The resulting compounds are effective to modulate activity of arylhydrocarbon receptors, to inhibit activity of PCSK9, and to stimulate secretion of glucagon-like peptide 1 in mammals.
FILED	Wednesday, August 05, 2015
APPL NO	14/818960
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 209/14 (20130101) Original (OR) Class C07D 403/06 (20130101) C07D 405/14 (20130101)
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09969726 — Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof

US 09969726	Cosford et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	Sanford-Burnham Medical Research Institute (La Jolla, California)
ASSIGNEE(S)	SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S)	Nicholas David Peter Cosford (La Jolla, California); Dhanya Raveendra-Panickar (La Jolla, California); Douglas J. Sheffler (La Jolla, California)
ABSTRACT	Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
FILED	Tuesday, June 09, 2015
APPL NO	15/315363
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/505 (20130101) A61K 31/506 (20130101) Heterocyclic Compounds C07D 231/12 (20130101) C07D 233/64 (20130101) C07D 239/26 (20130101) C07D 243/12 (20130101) C07D 249/08 (20130101) C07D 261/08 (20130101) C07D 263/32 (20130101) C07D 271/06 (20130101) C07D 275/02 (20130101) C07D 277/26 (20130101) C07D 277/30 (20130101) C07D 285/08 (20130101) C07D 307/38 (20130101) C07D 333/24 (20130101) C07D 401/04 (20130101) C07D 401/10 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 405/04 (20130101) C07D 405/10 (20130101) C07D 409/02 (20130101) C07D 409/04 (20130101) C07D 409/14 (20130101) C07D 413/04 (20130101) C07D 413/14 (20130101) C07D 417/04 (20130101) C07D 417/10 (20130101) C07D 417/14 (20130101) Original (OR) Class
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09969743 — Urea and amide derivatives of aminoalkylpiperazines and use thereof

US 09969743	Ananthan
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	Southern Research Institute (Birmingham, Alabama)
ASSIGNEE(S)	SOUTHERN RESEARCH INSTITUTE (Birmingham, Alabama)
INVENTOR(S)	Subramaniam Ananthan (Birmingham, Alabama)
ABSTRACT	Provided are compounds represented by the formula: In which: Y is an unbranched, saturated or unsaturated hydrocarbon chain with 2-5 hydrocarbon atoms R₁=aryl R₂=NR₃R₄wherein R₃and R₄together form a heterocycle or R₂=4-substitutedcyclohexyl, 1-substitutedpiperidine-4-yl or imidazo(1,2-a)azine-2-yl when Y is as defined above and R₁is a heterocycle other than benzothiophene pharmaceutically acceptable salts thereof, deuterated forms thereof, isomers thereof, solvates thereof, and mixtures thereof. The compounds can be used for treating a patient suffering from a condition that is capable of treatment with a partial agonist or antagonist of the dopamine D2/D3 receptors. The compounds are especially useful for patients suffering from schizophrenia, depressions, neurodegenerative diseases such as Parkinson's, dyskinesias, substance abuse and relapse to substance abuse and addiction to substances such as cocaine, methamphetamine, nicotine and alcohol, glaucoma, cognitive disorders, restless leg syndrome, attention deficit hyperactivity disorders, hyperprolactinemia, autism, motor disturbances such as akathisia, rigor, dystonias as well as various disorders of the urinary tract and other neurologic disorders. Also provided are processes for the preparation of compounds of the present disclosure.
FILED	Monday, March 20, 2017
APPL NO	15/463051
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 213/14 (20130101) C07D 215/38 (20130101) C07D 215/46 (20130101) C07D 239/42 (20130101) C07D 295/215 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) Original (OR) Class
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09969746 — Opioid compounds and their uses

US 09969746	Lewis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	THE UNIVERSITY OF BATH (Bath, United Kingdom); THE TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (Port St. Lucie, Florida); SRI INTERNATIONAL (Menlo Park, California)
ASSIGNEE(S)	The University of Bath (Bath, United Kingdom)
INVENTOR(S)	John Lewis (Bath and North East Somerset, United Kingdom); Stephen Husbands (Bath and North East Somerset, United Kingdom); Lawrence Toll (Port St. Lucie, Florida)
ABSTRACT	The present invention relates to opioid compounds, especially to C14 esters and ethers of naltrexone and analogs thereof. The present invention also relates to compositions, methods and medical uses that employ such compounds. More specifically, the present invention pertains to compounds of formula: and to their use in the treatment of diseases and disorders including pain, hyperalgesia, addiction, substance abuse disorders, stress, anorexia, anxiety, depression, cough, asthma, hypertension, gastrointestinal motility disorder, water retention, cognitive disorders, and locomotor disorders.
FILED	Friday, December 05, 2014
APPL NO	15/102066
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 489/02 (20130101) C07D 489/08 (20130101) Original (OR) Class
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09969759 — Duplex-selective organometallic DNA intercalators

US 09969759	Mirkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE) Division of Materials Research (DMR)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); Chad M. Shade (Chicago, Illinois); Robert D. Kennedy (Midland, Michigan); Jessica Lynn Rouge (Evanston, Illinois); Soyoung E. Seo (Evanston, Illinois); Mary X. Wang (Evanston, Illinois)
ABSTRACT	Disclosed herein are organometallic complexes and methods of using the same in detecting double stranded DNA or RNA, selectively over single stranded DNA or RNA.
FILED	Friday, May 22, 2015
APPL NO	15/312221
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0053 (20130101) Original (OR) Class Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 23/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6816 (20130101) C12Q 2563/173 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44726 (20130101) G01N 27/44747 (20130101) G01N 33/582 (20130101) G01N 33/587 (20130101) G01N 33/5308 (20130101)
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09969773 — Polymers, pharmaceutical compositions and methods of synthesizing the same

US 09969773	Kirshenbaum et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Integrative Organismal Systems (IOS) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Kent Kirshenbaum (New York, New York); Paul Levine (Somerville, Massachusetts); Timothy Craven (Randolph, New Jersey)
ASSIGNEE(S)	NEW YORK UNIVERSITY (New York, New York)
INVENTOR(S)	Kent Kirshenbaum (New York, New York); Paul Levine (Somerville, Massachusetts); Timothy Craven (Randolph, New Jersey)
ABSTRACT	Novel methods to prepare novel polymers are disclosed. Oxazolidinyl compounds according to formula IV: are also disclosed as intermediate compounds that can be reacted with an acid to form a polymer of formula I.
FILED	Thursday, April 16, 2015
APPL NO	14/688026
ART UNIT	1671 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 5/0823 (20130101) C07K 5/1024 (20130101) C07K 5/06165 (20130101) C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) C07K 14/001 (20130101) C07K 17/08 (20130101)
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09969781 — Compositions and methods to treat cancer with CpG rich DNA and cupredoxins

US 09969781	Das Gupta et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	Tapas Das Gupta (River Forest, Illinois); Ananda Chakrabarty (Villa Park, Illinois)
ASSIGNEE(S)
INVENTOR(S)	Tapas Das Gupta (River Forest, Illinois); Ananda Chakrabarty (Villa Park, Illinois)
ABSTRACT	The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG DNAs from Pseudomonas aeruginosa that are useful for treating cancer and other conditions in patients. These compositions are optionally in a pharmaceutically acceptable carrier and also optionally comprise a cupredoxin. The present invention further relates to methods to express proteins near cancer cells. These methods may be used to express therapeutic or diagnostic proteins near cancer cells in a patient suffering from cancer or other conditions, and can also be used for diagnosing cancer in a patient. This method uses the gene for azurin from P. aeruginosa as an expression system for azurin or heterologous proteins in P. aeruginosa or heterologous cells.
FILED	Monday, September 12, 2011
APPL NO	13/230055
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/21 (20130101) C07K 14/195 (20130101) Original (OR) Class
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09969782 — Highly immunogenic peptides derived from the human immunodeficiency virus V2 region

US 09969782	Cardozo
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	New York University (New York, New York)
ASSIGNEE(S)	New York University (New York, New York)
INVENTOR(S)	Timothy Cardozo (New York, New York)
ABSTRACT	The present invention relates to an isolated immunogenic peptide chimera comprising a first peptide moiety comprising the amino acid sequence of SEQ ID NO: 1, or at least a contiguous 5 amino acid fragment thereof, a second peptide moiety comprising the amino acid sequence of SEQ ID NO: 2, or at least a contiguous 5 amino acid fragment thereof, and a linker joining the first and second peptide moieties, wherein the first peptide moiety is at the immunogenic peptide chimera's N-terminus and the second peptide moiety is at the immunogenic peptide chimera's C-terminus. Also disclosed is an immunogenic peptide including the amino acid sequence corresponding to SEQ ID NO: 6, or at least a contiguous 5 amino acid fragment thereof, having a length sufficient to form β-hairpin structure. A further aspect of the present invention is an immunogenic peptide including the amino acid sequence corresponding to SEQ ID NO: 15, or at least a contiguous 5 amino acid fragment thereof, capable of folding into an alpha-helical structure. These immunogenic peptides can be inserted into an immunogenic scaffold protein to form an immunogenic polypeptide. The immunogenic peptides or immunogenic polypeptides can be used in an immunogenic vaccine composition and in methods of inducing a neutralizing antibody response, or inducing a protective and non-neutralizing antibody response, or protective antibodies, against HIV-1 gp120 in a subject. Isolated antibodies and methods of detecting are also disclosed.
FILED	Tuesday, October 07, 2014
APPL NO	14/508669
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 2039/6037 (20130101) Peptides C07K 14/28 (20130101) Original (OR) Class C07K 16/1063 (20130101) C07K 2317/21 (20130101) C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2319/33 (20130101) C07K 2319/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16134 (20130101)
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09969784 — Compositions and methods for modulation of immune function

US 09969784	Oliver et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Children's Hospital of Philadelphia (Philadelphia, Pennsylvania)
INVENTOR(S)	Paula M. Oliver (Merion, Pennsylvania); Christopher R. Riling (Exton, Pennsylvania)
ABSTRACT	Compositions and methods for modulating immune cell function and Nedd-4 family member signaling are disclosed.
FILED	Wednesday, May 07, 2014
APPL NO	14/889728
ART UNIT	1676 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 38/1709 (20130101) A61K 45/06 (20130101) Peptides C07K 14/47 (20130101) C07K 14/4702 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 2333/9015 (20130101) G01N 2500/20 (20130101)
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09969785 — Biglycan mutants and related therapeutics and methods of use

US 09969785	Fallon et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of Child Health and Human Development (NICHD) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Justin R. Fallon (Providence, Rhode Island); Alison R. Amenta (Pawtucket, Rhode Island); Beth A. McKechnie (North Attleboro, Massachusetts); Michelle Dechene (Providence, Rhode Island); Atilgan Yilmaz (Providence, Rhode Island)
ASSIGNEE(S)	Brown University (Providence, Rhode Island)
INVENTOR(S)	Justin R. Fallon (Providence, Rhode Island); Alison R. Amenta (Pawtucket, Rhode Island); Beth A. McKechnie (North Attleboro, Massachusetts); Michelle Dechene (Providence, Rhode Island); Atilgan Yilmaz (Providence, Rhode Island)
ABSTRACT	The present disclosure provides compositions and methods for treating diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, for example, due to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.
FILED	Tuesday, May 17, 2011
APPL NO	13/109558
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4725 (20130101) Original (OR) Class
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09969790 — Compositions and methods for immunomodulation in an organism

US 09969790	Lefrancois et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	UNIVERSITY OF CONNECTICUT (Farmington, Connecticut)
ASSIGNEE(S)	University of Connecticut (Farmington, Connecticut)
INVENTOR(S)	Leo Lefrancois (West Hartford, Connecticut); Thomas A. Stoklasek (Bristol, Connecticut)
ABSTRACT	The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.
FILED	Tuesday, May 17, 2016
APPL NO	15/156618
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/1793 (20130101) A61K 38/2086 (20130101) Peptides C07K 1/02 (20130101) C07K 14/55 (20130101) C07K 14/5443 (20130101) C07K 14/7155 (20130101) Original (OR) Class C07K 16/00 (20130101) C07K 2317/52 (20130101) C07K 2319/02 (20130101) C07K 2319/30 (20130101) C07K 2319/31 (20130101)
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09969797 — Immunoglobulins directed to bacterial, viral and endogenous polypeptides

US 09969797	Paul et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Sudhir Paul (Missouri City, Texas); Stephanie Planque (Houston, Texas); Yasuhiro Nishiyama (Houston, Texas); Eric L. Brown (Houston, Texas); Keri C. Smith (Houston, Texas); Hiroaki Taguchi (Houston, Texas)
ASSIGNEE(S)	Covalent Bioscience Incorporated (Tuxedo Park, New York)
INVENTOR(S)	Sudhir Paul (Missouri City, Texas); Stephanie Planque (Houston, Texas); Yasuhiro Nishiyama (Houston, Texas); Eric L. Brown (Houston, Texas); Keri C. Smith (Houston, Texas); Hiroaki Taguchi (Houston, Texas)
ABSTRACT	Disclosed are antibodies (immunoglobulins) and fragments thereof that hydrolyze or bind polypeptide antigens belonging to Staphyloccus aureus, hepatitis C virus, human immunodeficiency virus and Alzheimer's disease. Also disclosed are novel methods to improve the antigen reactivity of the immunoglobulins and to treat a pathophysiological condition using the immunoglobulins as therapeutics.
FILED	Friday, October 23, 2009
APPL NO	12/589440
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/109 (20130101) C07K 16/1063 (20130101) C07K 16/1271 (20130101) C07K 2317/52 (20130101) C07K 2317/56 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101)
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09969803 — Monoclonal antibodies that inhibit the Wnt signaling pathway and methods of production and use thereof

US 09969803	Ma et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S)	The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
INVENTOR(S)	Jian-xing Ma (Edmond, Oklahoma); Kyungwon Lee (Oklahoma City, Oklahoma); Ying Chen (Oklahoma City, Oklahoma)
ABSTRACT	Monoclonal antibodies against LRP6 and that block the Wnt signaling pathway are disclosed. Methods of production and use thereof are also disclosed.
FILED	Monday, April 04, 2016
APPL NO	15/089937
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/28 (20130101) Original (OR) Class C07K 16/30 (20130101) C07K 2317/24 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2317/624 (20130101)
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09969804 — Methods and compositions for treating and preventing disease associated with alpha-V beta-8 integrin

US 09969804	Sheppard et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Dean Sheppard (Oakland, California); Amha Atakilit (Oakland, California); Neil Cowan Henderson (Edinburgh, United Kingdom)
ABSTRACT	Antibodies (e.g., isolated antibodies) that specifically bind to human integrin β8 and inhibit adhesion of latency associated peptide (LAP) to αvβ8 are provided. In some embodiments, the antibody cross-reacts with mouse integrin β8. In some embodiments, the antibody blocks TGFJ3 activation. In some embodiments, the antibody antagonizes binding of LAP to αβ8 with an IC50 below 5 nM.
FILED	Tuesday, April 01, 2014
APPL NO	14/778997
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/2839 (20130101) Original (OR) Class C07K 2317/33 (20130101) C07K 2317/76 (20130101) C07K 2317/567 (20130101)
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09969858 — Metalloinsertor conjugates

US 09969858	Weidmann et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Alyson Weidmann (San Jose, California); Jacqueline K. Barton (San Marino, California)
ABSTRACT	A composition including a metalloinsertor conjugate that specifically targets mismatch repair (MMR)-deficient cells includes a complex represented by Formula I. M^m+(L₁)(L₂)(L₃)(L₄)(L₅) Formula I Selective cytotoxicity may be induced in MMR-deficient cells upon uptake of the metalloinsertor conjugate. Metalloinsertor complexes conjugated with platinum (Pt) may allow for more specific targeting of platinum anticancer agents.
FILED	Friday, January 29, 2016
APPL NO	15/011476
ART UNIT	1621 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/28 (20130101) A61K 31/555 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/08 (20130101) Original (OR) Class
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09969964 — Disease-on-a-chip

US 09969964	Lelievre et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
INVENTOR(S)	Sophie Andree Lelievre (West Lafayette, Indiana); Pierre-Alexandre Vidi (West Lafayette, Indiana); James Francis Leary (West Lafayette, Indiana); Teimour Maleki-Jafarabadi (Thousand Oaks, California)
ABSTRACT	The invention generally relates to a cell culture system for coculturing non-neoplastic and neoplastic cells on a planar member which more faithfully mimics the in vivo geometry of a lumen or a cavity.
FILED	Friday, December 19, 2014
APPL NO	14/577326
ART UNIT	1799 — Miscellaneous Articles, Stock Material
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 23/04 (20130101) C12M 23/12 (20130101) C12M 23/20 (20130101) Original (OR) Class
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09969970 — DNA-cell conjugates

US 09969970	Hsiao et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Basic Energy Sciences (BES) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Shih-Chia Hsiao (Oakland, California); Matthew B. Francis (Berkeley, California); Carolyn Bertozzi (Berkeley, California); Richard Mathies (Walnut Creek, California); Ravi Chandra (Newton, Massachusetts); Erik Douglas (Oakland, California); Amy Twite (Berkeley, California); Nicholas Toriello (San Carlos, California); Hiroaki Onoe (Tokyo, Japan)
ABSTRACT	The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
FILED	Tuesday, March 01, 2016
APPL NO	15/057604
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/6901 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) Original (OR) Class
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09969974 — Differntiation method for production of glial cell population

US 09969974	Tesar et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Paul J. Tesar (Wickliffe, Ohio); Robert H. Miller (Cleveland Heights, Ohio); Fadi J. Najm (University Heights, Ohio)
ABSTRACT	The present invention provides methods for generating oligodendrocyte progenitor cells from pluripotent cells, as well as methods for sustaining these oligodendrocyte progenitor cells in relatively pure cultures for long periods of time. The present invention also provides methods for further differentiating these oligodendrocyte progenitor cells into various glial cells.
FILED	Monday, November 23, 2015
APPL NO	14/949578
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 2501/01 (20130101) C12N 2501/13 (20130101) C12N 2501/16 (20130101) C12N 2501/41 (20130101) C12N 2501/105 (20130101) C12N 2501/115 (20130101) C12N 2501/135 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101)
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09969987 — Split peroxidases and methods of use

US 09969987	Ting et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Alice Y. Ting (Allston, Massachusetts); Jeffrey Daniel Martell (Somerville, Massachusetts)
ABSTRACT	An imaging method utilizing a split peroxidase is described herein. Imaging methods involve contacting a cell with a split peroxidase and a substrate thereof to allow conversion of a substrate into a product via an enzymatic reaction catalyzed by the reconstitute split peroxidase. Also disclosed herein are split peroxidases, related products and kits.
FILED	Wednesday, April 01, 2015
APPL NO	14/675777
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0065 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/28 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/581 (20130101)
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09970014 — Factor V/Va-targeting aptamer compositions and methods of using the same

US 09970014	Soule et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Erin Soule (Durham, North Carolina); Bruce A. Sullenger (Durham, North Carolina)
ABSTRACT	Provided herein are Factor V/Factor Va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are also provided.
FILED	Monday, June 12, 2017
APPL NO	15/620143
ART UNIT	1674 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/115 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2310/113 (20130101) C12N 2310/322 (20130101) C12N 2310/531 (20130101) C12N 2310/3517 (20130101) C12N 2320/30 (20130101) C12N 2320/50 (20130101)
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09970024 — RNA-guided human genome engineering

US 09970024	Church et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	George M. Church (Brookline, Massachusetts); Prashant Mali (Somerville, Massachusetts); Luhan Yang (Somerville, Massachusetts)
ABSTRACT	A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner.
FILED	Monday, December 16, 2013
APPL NO	14/653144
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/01 (20130101) C12N 15/10 (20130101) C12N 15/63 (20130101) C12N 15/81 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 15/87 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) C12N 15/1024 (20130101) C12N 15/8201 (20130101) C12N 2800/80 (20130101) C12N 2810/55 (20130101) Enzymes C12Y 301/00 (20130101)
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09970057 — Human invasion signature for prognosis of metastatic risk

US 09970057	Condeelis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	John Condeelis (Bronx, New York); Antonia Patsialou (Pelham, New York)
ASSIGNEE(S)	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (Bronx, New York)
INVENTOR(S)	John Condeelis (Bronx, New York); Antonia Patsialou (Pelham, New York)
ABSTRACT	Methods and products are provided for determining if a subject having a tumor is (i) at risk of metastasis of the tumor, or (ii) at risk of recurrence of the tumor after treatment of the tumor. Methods of treatment of cancer, tumors and metastasis are also provided.
FILED	Friday, May 04, 2012
APPL NO	14/115928
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101)
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09970058 — Digital amplification

US 09970058	Vogelstein et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland)
ABSTRACT	The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules can be isolated by dilution and individually amplified; each product is then separately analyzed for the presence of pre-defined mutations. The process provides a reliable and quantitative measure of the proportion of variant sequences within a DNA sample.
FILED	Monday, October 13, 2014
APPL NO	14/512694
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6818 (20130101) C12Q 1/6851 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/158 (20130101)
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09970059 — Survival predictor for diffuse large B cell lymphoma

US 09970059	Rimsza et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona); Queen Mary University of London (London, United Kingdom); Board of Regents of the University of Nebraska (Lincoln, Nebraska); Oslo University Hospital HF (Oslo, Norway); Oregon Health and Science University (Portland, Oregon); University of Rochester (Rochester, New York); Hospital Clinic de Barcelona (Barcelona, Spain); Universitat De Barcelona (Barcelona, Spain); British Columbia Cancer Agency Branch (Vancouver, Canada); Julius-Maximilians-University of Wuerzburg (Wuerzburg, Germany)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Human Services (Washington, District of Columbia); Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona); Queen Mary University of London (London, United Kingdom); Board of Regents of the University of Nebraska (Lincoln, Nebraska); Oslo University Hospital HF (Oslo, Norway); Oregon Health and Science University (Portland, Oregon); University of Rochester (Rochester, New York); Hospital Clinic de Barcelona (Barcelona, Spain); Universitat de Barcelona (Barcelona, Spain); British Columbia Cancer Agency Branch (Vancouver, Canada); Julius-Maximilians-University of Würzburg (Würzburg, Germany)
INVENTOR(S)	Lisa Rimsza (Tucson, Arizona); Andrew T. Lister (London, United Kingdom); Wing C. Chan (Omaha, Nebraska); Dennis Weisenburger (Elkhorn, Nebraska); Jan Delabie (Oslo, Norway); Erlend B. Smeland (Oslo, Norway); Harald Holte (Oslo, Norway); Stein Kvaloy (Oslo, Norway); Rita M. Braziel (West Linn, Oregon); Richard I. Fisher (Pittsford, New York); Pedro Jares (Barcelona, Spain); Armando Lopez-Guillermo (Barcelona, Spain); Elias Campo Guerri (Barcelona, Spain); Elaine S. Jaffe (Great Falls, Virginia); Georg Lenz (Berlin, Germany); Wyndham H. Wilson (Washington, District of Columbia); George Wright (Rockville, Maryland); Sandeep S. Dave (Chapel Hill, North Carolina); Louis M. Staudt (Bethesda, Maryland); Randy D. Gascoyne (North Vancouver, Canada); Joseph M. Connors (Vancouver, Canada); Hans-Konrad Muller-Hermelink (Wrzburg, Germany); Andreas Rosenwald (Wuerzburg, Germany); German Ott (Bietigheim-Bissingen, Germany)
ABSTRACT	The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
FILED	Thursday, November 13, 2014
APPL NO	14/540302
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) G01N 2800/52 (20130101) G01N 2800/56 (20130101)
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09970063 — Compositions and methods for identifying bacterial clonotypes and detecting antibiotic susceptibility

US 09970063	Chattopdhyay
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	ID Genomics, Inc. (Seattle, Washington)
ASSIGNEE(S)	ID Genomics, Inc. (Seattle, Washington)
INVENTOR(S)	Sujay Chattopdhyay (Seattle, Washington)
ABSTRACT	There is disclosed a PCR-based test kit and PCR process for identification of multiple clonal sub-species lineages of infectious bacteria, such as uropathogenic E. coli causing cystitis. pyelonephritis and urosepsis, for the purposes of predicting antibiotic resistance of the bacteria. More specifically, there is further disclosed a SNP (single nucleotide polymorphism) identification process that simultaneously detect compilations of the presence of absence of predictive SNPs within mutated loci of infectious bacterial clonal subspecies variants, such as the fumC/fimH loci of the E. coli bacterium. This disclosure provides a PCR detection kit incorporating a SNP compilation that forms a BFC (Binary Footprint Code) that allows for rapid identification of multiple infectious bacterial clonotypes based on their SNP footprint. More specifically there is disclosed a clonotyping method for clonal typing E. coli and predicting antibiotic susceptibility, comprising (a) providing forward primers and reverse primers for at least seven SNPs (single nucleotide polymorphisms) selected from the group consisting of fumC-63, fumC-248, fumC-380, fimH-162, fimH-233, fimH-483, and fimH-108, (b) measuring the presence or absence of each SNP, and (c) determining antibiotic susceptibility from Lookup Table 1.
FILED	Friday, February 26, 2016
APPL NO	15/055376
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101)
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09970853 — Ultrasonic horn actuated microprobes based self-calibrating viscosity sensor

US 09970853	Lal et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Amit Lal (Ithaca, New York); Ramkumar Abhishek (Mountain View, California)
ASSIGNEE(S)	Cornell University (Ithaca, New York)
INVENTOR(S)	Amit Lal (Ithaca, New York); Ramkumar Abhishek (Mountain View, California)
ABSTRACT	An ultrasonic or acoustic viscosity sensor or viscometer is provided that can be used to accurately measure viscosity for fluid samples of less than 1 μl in volume. Methods for measuring viscosity for fluid samples of less than 1 μl in volume are also provided. The viscosity sensor and methods based thereon enable simultaneous measurement of bulk and dynamic (shear-rate dependent) viscosity of a non-Newtonian fluid. Bulk and dynamic viscosity of the non-Newtonian fluid can be measured simultaneously without separating constituents of the fluid, and thus distinguishing the effect of constituents on the viscosity. Dynamic viscosity of the non-Newtonian fluid can be estimated at varying shear rates, to study the deformability of the constituents of the fluid as a function of shear rate.
FILED	Thursday, July 14, 2011
APPL NO	13/810648
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/16 (20130101) Original (OR) Class G01N 29/036 (20130101) G01N 29/2437 (20130101) G01N 2291/02818 (20130101)
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09970898 — Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis

US 09970898	Ramsey et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S)	John Michael Ramsey (Chapel Hill, North Carolina); Laurent Menard (Cary, North Carolina)
ABSTRACT	Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells, nuclei, whole chromosomes, or other sources of long DNA molecules. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
FILED	Tuesday, March 11, 2014
APPL NO	14/771989
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/683 (20130101) C12Q 1/683 (20130101) C12Q 1/6869 (20130101) C12Q 2561/113 (20130101) C12Q 2565/631 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) Original (OR) Class G01N 33/48721 (20130101)
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09970935 — Uses of GLI1 in detecting tissue fibrosis

US 09970935	Humphreys et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S)	THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
INVENTOR(S)	Benjamin D. Humphreys (Brookline, Massachusetts); Rafael Kramann (Lemiers, Netherlands); Derek Dirocco (Brookline, Massachusetts)
ABSTRACT	Methods are provided herein for the use of Gli-1 as a specific marker for myofibroblast progenitor cells, thereby permitting the diagnosis of early stages of fibrosis prior to the onset of organ failure. Also provided herein are methods of isolating Gli-1+ cells for e.g., use in high-throughput screening of compounds for the treatment or prevention of fibrosis. In another aspect, provided herein are methods of treating or preventing fibrosis (e.g., kidney fibrosis) in a subject by administering a Gli inhibitor, particularly a Gli-2 inhibitor or a Gli-1/Gli-2 inhibitor.
FILED	Friday, February 06, 2015
APPL NO	15/116722
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/063 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0668 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) G01N 33/6887 (20130101) G01N 33/56966 (20130101) Original (OR) Class G01N 2333/4703 (20130101) G01N 2333/4712 (20130101) G01N 2800/085 (20130101) G01N 2800/347 (20130101)
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09970941 — Methods and products for in vivo enzyme profiling

US 09970941	Bhatia et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Sangeeta N. Bhatia (Lexington, Massachusetts); Geoffrey A. von Maltzahn (Boston, Massachusetts); Gabriel A. Kwong (Boston, Massachusetts)
ABSTRACT	The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention.
FILED	Tuesday, January 28, 2014
APPL NO	14/166481
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 7/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) C12Q 1/56 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) G01N 33/6848 (20130101) Original (OR) Class
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09970945 — Compositions, methods, and assays using proteo-liposome-transfected oocytes for analyzing the structure, function, and activity of membrane proteins

US 09970945	Tai et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Georgia State University Research Foundation, Inc. (Atlanta, Georgia)
ASSIGNEE(S)	Georgia State University Research Foundtion, Inc. (Atlanta, Georgia)
INVENTOR(S)	Phang-Cheng Tai (Atlanta, Georgia); Ying-hsin Hsieh (Atlanta, Georgia); Chun Jiang (Marietta, Georgia); Jenny Jie Yang (Marietta, Georgia); Juan Zou (Atlanta, Georgia)
ABSTRACT	Compositions and methods for reconstituting a protein of interest in the plasma membrane of a Xenopus oocyte are disclosed. The method generally includes combining a preassembled membrane protein or proteins with a liposome to prepare a proteo-liposome. The proteo-liposome can have a specific composition of lipids. The proteo-liposome is incubated for sufficient time and under conditions suitable for the protein of interest to fold, associate with, or insert into the liposome's lipid bilayer. In some embodiments, the protein or proteins assemble into a protein channel or complex on or in the proteo-liposome's membrane. The treated oocytes can be used to determine the structure, function, or activity of the membrane protein of interest, the effect of a lipid microenvironment on a membrane protein of interest, or to identify compounds that modulate the function or activity of the membrane protein of interest.
FILED	Monday, June 09, 2014
APPL NO	14/896437
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 33/5044 (20130101) G01N 33/6872 (20130101) Original (OR) Class G01N 33/48728 (20130101)
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09970947 — Fluorescent probe

US 09970947	Lemasters et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina)
ASSIGNEE(S)	MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina)
INVENTOR(S)	John J. Lemasters (Johns Island, South Carolina); Andaleb I. Kholmukhamedov (Milwaukee, Wisconsin); Christopher Lindsey (Wadmalaw Island, South Carolina); Craig C. Beeson (Charleston, South Carolina)
ABSTRACT	Provided herein is a fluorescent probe compound of formula (I): as well as methods of using said compound.
FILED	Wednesday, March 29, 2017
APPL NO	15/472414
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0043 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 11/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/84 (20130101) Original (OR) Class G01N 33/582 (20130101) G01N 2021/6432 (20130101) G01N 2021/6439 (20130101) G01N 2800/7009 (20130101) G01N 2800/7019 (20130101)
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09971136 — Method and device to achieve spatially confined photointeraction at the focal volume of a microscope

US 09971136	Pantazis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	ETH ZÜRICH (Zürich, Switzerland); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	ETH ZÜRICH (Zürich, Switzerland); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Periklis Pantazis (Oberwil, Switzerland); William P. Dempsey (Sunland, California); Thai V. Truong (Pasadena, California); Scott E. Fraser (Glendale, California); Lada Georgieva (Basel, Switzerland)
ABSTRACT	The invention relates to a method and a system to achieve spatially (e.g. three-dimensionally) confined photomodulation at the focal volume (50) in a ample (55) mounted in a microscope system, comprising two or more laser light sources (41, 42) emitting light (32, 34) of different wavelengths adapted to excite a material in an identical number of independent excitation steps to a higher vibrational state from which the material relaxes, either emitting a conversion light to be detected (“photoexcitation”) or modulating the spectral properties of the material (“photomodulation”).
FILED	Thursday, March 20, 2014
APPL NO	14/778618
ART UNIT	2884 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6408 (20130101) G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 2021/1785 (20130101) Optical Elements, Systems, or Apparatus G02B 5/201 (20130101) G02B 21/0032 (20130101) G02B 21/0076 (20130101) Original (OR) Class G02B 27/141 (20130101)
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09971164 — Fluorescence collection objective optical system and method

US 09971164	McMullen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Center for Research Resources (NCRR)
APPLICANT(S)	Jesse McMullen (Mississauga, Canada); Warren Zipfel (Ithaca, New York)
ASSIGNEE(S)	Cornell University (Ithaca, New York)
INVENTOR(S)	Jesse McMullen (Mississauga, Canada); Warren Zipfel (Ithaca, New York)
ABSTRACT	An optical system particularly suited for non-linear fluorescence collecting includes a front lens system, a rear lens system, and a bulk, dichroic beam splitting component intermediate the front lens system and the rear lens system to direct the fluorescent emission from a target object to a photodetector. A lens housing may have a reflective coating on an interior surface thereof. The objective optical system is particularly advantageous for use in cases where large fields of view and high collection efficiencies are desirable.
FILED	Tuesday, February 08, 2011
APPL NO	13/576787
ART UNIT	2872 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Optical Elements, Systems, or Apparatus G02B 21/02 (20130101) G02B 21/33 (20130101) G02B 27/141 (20130101) G02B 27/145 (20130101) Original (OR) Class
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09971936 — Adaptive signal detection and synthesis on trace data

US 09971936	Humphrey
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Li-Cor, Inc. (Lincoln, Nebraska)
ASSIGNEE(S)	LI-COR, Inc. (Lincoln, Nebraska)
INVENTOR(S)	Patrick G. Humphrey (Lincoln, Nebraska)
ABSTRACT	Systems and methods for detecting, decoupling and quantifying unresolved signals in trace signal data in the presence of noise with no prior knowledge of the signal characteristics (e.g., signal peak location, intensity and width) of the unresolved signals. The systems and methods are useful for analyzing any trace data signals having one or multiple overlapping constituent signals and particularly useful for analyzing data signals which often contain an unknown number of constituent signals with varying signal characteristics, such as peak location, peak intensity and peak width, and varying resolutions. A general signal model function is assumed for each unknown, constituent signal in the trace signal data. In a first phase, the number of constituent signals and signal characteristics are determined automatically in a parallel fashion by executing multiple simultaneous evaluations iteratively starting with an initial set of trial signals. Making simultaneous evaluations and systematically reducing the number of trial signals allows for convergence to an optimal, final set of signals in a very fast and efficient manner.
FILED	Friday, June 17, 2016
APPL NO	15/185983
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0053 (20130101) Original (OR) Class G06K 9/00503 (20130101)
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09972649 — Nanowire FET imaging system and related techniques

US 09972649	Spanoudaki et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	Virginia Spanoudaki (Cambridge, Massachusetts); Daniel G. Anderson (Sudbury, Massachusetts); Robert S. Langer (Newton, Massachusetts)
ABSTRACT	A sensor comprises a substrate; an array of nanowire field effect transistors (NWFETs) formed in said substrate, each of the NWFETs having source, drain and gate terminals; a nanowire coupled between the source terminal and the drain terminal of each NWFET; and a layer of radiation sensitive material disposed over said NWFETs and said nanowires with each of the source, drain and gate terminals configured to be coupled to respective ones of first, second or third reference potentials, wherein each NWFET is configured such that the conductivity between the source and drain changes in response to radiation absorbed in the layer of radiation sensitive material such that the sensor generates an output signal in response to radiation absorbed by the radiation sensitive material.
FILED	Monday, October 17, 2016
APPL NO	15/294914
ART UNIT	2884 — Optics
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14605 (20130101) H01L 27/14616 (20130101) Original (OR) Class H01L 27/14636 (20130101) H01L 29/0669 (20130101)
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09972867 — Cosolvent electrolytes for electrochemical devices

US 09972867	Wessells et al.
FUNDED BY	Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Alveo Energy, Inc. (Palo Alto, California)
ASSIGNEE(S)	Natron Energy, Inc. (Santa Clara, California)
INVENTOR(S)	Colin Deane Wessells (Palo Alto, California); Ali Firouzi (Saratoga, California); Shahrokh Motallebi (Los Gatos, California); Sven Strohband (Menlo Park, California)
ABSTRACT	A system and method for stabilizing electrodes against dissolution and/or hydrolysis including use of cosolvents in liquid electrolyte batteries for three purposes: the extension of the calendar and cycle life time of electrodes that are partially soluble in liquid electrolytes, the purpose of limiting the rate of electrolysis of water into hydrogen and oxygen as a side reaction during battery operation, and for the purpose of cost reduction.
FILED	Sunday, March 06, 2016
APPL NO	15/062171
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/36 (20130101) H01M 4/58 (20130101) H01M 4/60 (20130101) H01M 4/485 (20130101) H01M 4/505 (20130101) H01M 4/9008 (20130101) H01M 8/188 (20130101) H01M 10/08 (20130101) H01M 10/36 (20130101) H01M 10/345 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2004/027 (20130101) H01M 2220/10 (20130101) H01M 2220/20 (20130101) H01M 2250/10 (20130101) H01M 2250/20 (20130101) H01M 2300/0002 (20130101) H01M 2300/004 (20130101) H01M 2300/0025 (20130101) H01M 2300/0028 (20130101) H01M 2300/0037 (20130101) H01M 2300/0091 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 90/14 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 90/32 (20130101)
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09972914 — Monopole array arrangement, computer-accessible medium and method for using the same

US 09972914	Wiggins et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)	New York University (New York, New York)
INVENTOR(S)	Graham Charles Wiggins (New York, New York); Gang Chen (New York, New York)
ABSTRACT	An array arrangement according to an exemplary embodiment of the present disclosure can be provided. For example, the array arrangement can include a monopole array having a first end and a second end. The monopole array can be configured to be driven from the first end and from the second end. Further, a monopole array can be provided according to another exemplary embodiment of the present disclosure. For example, the monopole array can include a first monopole element can include a first antenna element, and a first grounding element in communication with the first antenna element. The monopole array can also include a second monopole element including a second antenna element, and a second grounding element in communication with the second antenna element. The first antenna element can be oriented in a first direction, and the second antenna element can be oriented in a second direction.
FILED	Monday, November 17, 2014
APPL NO	14/543165
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3415 (20130101) G01R 33/34038 (20130101) Antennas, i.e Radio Aerials H01Q 9/30 (20130101) H01Q 21/00 (20130101) Original (OR) Class H01Q 21/205 (20130101)
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Department of Defense (DOD)

09968571 — Inhibitors and methods of inhibiting bacterial and viral pathogens

US 09968571	Allen, III et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA)
APPLICANT(S)	SIGA TECHNOLOGIES, INC. (Corvallis, Oregon)
ASSIGNEE(S)	SIGA TECHNOLOGIES, INC. (Corvallis, Oregon)
INVENTOR(S)	Robert D. Allen, III (Corvallis, Oregon); Sean M. Amberg (Corvallis, Oregon); Dongcheng Dai (Corvallis, Oregon); James R. Burgeson (Albany, Oregon); Dennis E. Hruby (Albany, Oregon)
ABSTRACT	Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.
FILED	Thursday, December 22, 2016
APPL NO	15/388715
ART UNIT	1621 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) Original (OR) Class A61K 31/675 (20130101) A61K 31/4406 (20130101) A61K 31/4409 (20130101) A61K 31/7056 (20130101) A61K 38/21 (20130101) A61K 45/06 (20130101) A61K 47/60 (20170801) Acyclic or Carbocyclic Compounds C07C 335/20 (20130101) C07C 335/26 (20130101) C07C 335/38 (20130101) Heterocyclic Compounds C07D 213/81 (20130101) C07D 213/82 (20130101) C07D 495/04 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 514/888 (20130101)
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09968637 — Dopaminergic neurons differentiated from pluripotent stem cells and uses thereof

US 09968637	Cooper et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE MCLEAN HOSPITAL CORPORATION (Belmont, Massachusetts)
ASSIGNEE(S)	THE MCLEAN HOSPITAL CORPORATION (Belmont, Massachusetts)
INVENTOR(S)	Oliver Cooper (Jamaica Plain, Massachusetts); Ole Isacson (Cambridge, Massachusetts)
ABSTRACT	The present invention provides populations of neural cells derived from pluripotent cells, and methods for making and using the same. Disclosed herein are methods for generating dopaminergic neurons in vitro using a combination of agents that cause differentiation of the pluripotent cells into dopaminergic neurons. Also disclosed are methods for treating a neurodegenerative disease in a patient by generating dopaminergic neurons in vitro, and transplanting them into the brain of the patient, such that the dopaminergic neurons are sufficient to reduce or eliminate the symptoms of the neurodegenerative disease.
FILED	Thursday, May 21, 2015
APPL NO	14/718683
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 2500/38 (20130101) C12N 2501/01 (20130101) C12N 2501/13 (20130101) C12N 2501/15 (20130101) C12N 2501/41 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/415 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101)
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09968667 — Targets and compositions for use in decontamination, immunoprophylaxis, and post-exposure therapy against anthrax

US 09968667	Huang et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Altimmune Inc. (Gaithersburg, Maryland)
ASSIGNEE(S)	Altimmune Inc. (Gaithersburg, Maryland)
INVENTOR(S)	Chun-Ming Huang (Gaithersburg, Maryland); JianFeng Zhang (Gaithersburg, Maryland); De-Chu Tang (Gaithersburg, Maryland)
ABSTRACT	The present invention relates to the decontamination of anthrax spores, prophylaxis and treatment of anthrax infections and, more particularly, to compounds that act as specific inhibitors of B. anthracis germination/outgrowth-associated proteins, methods and means for making such inhibitors and their use as pharmaceuticals and/or vaccines. The invention also relates to the prophylaxis and treatment of anthrax infections and, more particularly, to vaccines and compositions that comprise B. anthracis antigens, epitopes, proteins, or nucleic acid molecules, including anthrax protective antigen, anthrax lethal factor, anthrax edema factor and anthrax proteins associated with spore germination and outgrowth, as well as methods and means for making such compositions and their use pharmaceuticals and/or vaccines.
FILED	Wednesday, September 30, 2015
APPL NO	14/870570
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/07 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/57 (20130101) A61K 2039/523 (20130101) A61K 2039/543 (20130101) A61K 2039/552 (20130101) A61K 2039/5256 (20130101) Peptides C07K 14/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10043 (20130101)
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09968669 — Gene optimized hantaan virus M segment DNA vaccine for hemorrhagic fever with renal syndrome

US 09968669	Schmaljohn
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Connie Schmaljohn (Middletown, Maryland)
ABSTRACT	A synthetic, codon-optimized Hantaan virus (HTNV) full-length M gene open reading frame that consists of a unique nucleotide sequence encoding HTNV proteins. This synthetic gene was cloned into a plasmid to form the first optimized HTNV full-length M gene that elicits neutralizing antibodies in animals when delivered in combination with a similarly optimized Puumala virus (PUUV) DNA vaccine. The invention obviates the need for an extraneous gene sequence that was previously required for expression of the non-optimized HTNV gene. The synthetic gene is engineered into a molecular vaccine system to prevent hemorrhagic fever with renal syndrome (HFRS) caused by infection with HTNV, SEOV, or DOBV. Alternatively, it can be combined with the optimized PUUV DNA vaccine to protect against HFRS caused by any hantavirus.
FILED	Friday, January 06, 2017
APPL NO	15/400028
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 9/12 (20130101) A61K 9/0019 (20130101) A61K 9/0021 (20130101) A61K 9/51 (20130101) A61K 9/0073 (20130101) A61K 9/5115 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 39/385 (20130101) A61K 2039/53 (20130101) A61K 2039/70 (20130101) A61K 2039/575 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/12122 (20130101) C12N 2760/12134 (20130101) C12N 2760/12171 (20130101) C12N 2800/22 (20130101)
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09968698 — Charged singlet-oxygen sensitizers and oppositely-charged surfactants

US 09968698	Whitten et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S)	STC. UNM (Albuquerque, New Mexico)
INVENTOR(S)	David G. Whitten (Albuquerque, New Mexico); Eric H. Hill (Albuquerque, New Mexico); Harry C. Pappas (Albuquerque, New Mexico)
ABSTRACT	The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.
FILED	Wednesday, November 05, 2014
APPL NO	14/533612
ART UNIT	1799 — Organic Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/30 (20130101) A01N 25/30 (20130101) A01N 33/12 (20130101) A01N 33/12 (20130101) A01N 33/12 (20130101) A01N 41/02 (20130101) A01N 41/04 (20130101) A01N 41/04 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/18 (20130101) Original (OR) Class
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09968706 — Nerve regeneration employing keratin biomaterials

US 09968706	Van Dyke
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	Wake Forest University Health Sciences (Winston-Salem, North Carolina)
ASSIGNEE(S)	Wake Forest University Health Sciences (Winston-Salem, North Carolina)
INVENTOR(S)	Mark E. Van Dyke (Winston-Salem, North Carolina)
ABSTRACT	A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.
FILED	Friday, January 23, 2015
APPL NO	14/603616
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/185 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/227 (20130101) A61L 2300/414 (20130101) A61L 2430/32 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 524/916 (20130101)
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09968711 — Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same

US 09968711	Biris
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas)
ASSIGNEE(S)	BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas)
INVENTOR(S)	Alexandru S. Biris (Little Rock, Arkansas)
ABSTRACT	A method of treating bone deficiencies includes applying a biocompatible structure to an implant surgical site. The biocompatible structure includes multiple polymer layers stacked to have a predetermined shape, multiple bone particle layers disposed between each of two neighboring polymer layers of the multiple polymer layers, and a coating surrounding the polymer layers and bone particle layers. Each of the polymer layers is formed with a polymer and first tissue forming nanoparticles. The predetermined shape is configured to conform to the implant surgical site.
FILED	Wednesday, July 27, 2016
APPL NO	15/220727
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/28 (20130101) A61F 2/2846 (20130101) A61F 2002/2835 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/38 (20130101) A61L 27/44 (20130101) A61L 27/46 (20130101) A61L 27/46 (20130101) A61L 27/46 (20130101) A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) Original (OR) Class A61L 27/365 (20130101) A61L 27/3608 (20130101) A61L 2300/64 (20130101) A61L 2300/412 (20130101) A61L 2300/414 (20130101) A61L 2400/12 (20130101) A61L 2400/18 (20130101) A61L 2430/02 (20130101) Compositions of Macromolecular Compounds C08L 5/00 (20130101) C08L 67/04 (20130101) Technical Subjects Covered by Former US Classification Y10T 156/1062 (20150115) Y10T 156/1075 (20150115)
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09968892 — Functionalization of nanofibrous microfiltration membranes for water purification

US 09968892	Chu et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Benjamin Chu (Setauket, New York); Benjamin S. Hsiao (Setauket, New York); HongYang Ma (East Setauket, New York)
ASSIGNEE(S)	NATIONAL SCIENCE FOUNDATION (Arlington, Virginia)
INVENTOR(S)	Benjamin Chu (Setauket, New York); Benjamin S. Hsiao (Setauket, New York); HongYang Ma (East Setauket, New York)
ABSTRACT	A high flux and low pressure drop microfiltration (MF) membrane and a method for making the MF membrane. The microfiltration membranes are formed by a method that includes: preparing a nanofibrous structure; and modifying the surface of the nanofibrous structure with a surface modifier. The nanofibrous structure includes an electrospun nanofibrous scaffold or a polysaccharide nanofiber infused nanoscaffold or mixtures thereof. The electrospun nanofibrous scaffold can include polyacrylonitrile (PAN) or polyethersulfone (PES))/polyethylene terephthalate (PET) or mixtures thereof. The surface modifier includes polyethylenimine (PEI) and polyvinyl amine (Lupamin) cross-linked by ethylene glycol diglycidyl ether (EGdGE)/glycidyltrimethylammonium chloride (GTMACl) or poly(1-(1-vinylimidazolium)ethyl-3-vinylimdazolium dibromide (VEVIMIBr).
FILED	Wednesday, January 04, 2012
APPL NO	14/362028
ART UNIT	1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 61/147 (20130101) B01D 67/0004 (20130101) B01D 67/0006 (20130101) B01D 69/02 (20130101) B01D 69/10 (20130101) B01D 69/12 (20130101) B01D 69/125 (20130101) B01D 71/42 (20130101) B01D 71/48 (20130101) B01D 71/60 (20130101) Original (OR) Class B01D 71/68 (20130101) B01D 2323/30 (20130101) B01D 2323/39 (20130101) B01D 2325/20 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 37/0025 (20130101) B29C 47/0014 (20130101) B29C 47/0076 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2033/20 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/14 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/18 (20130101) D01F 11/06 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/728 (20130101)
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09968906 — Reforming with oxygen-enriched matter

US 09968906	DuBois
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Terry DuBois (Forest Hill, Maryland)
ABSTRACT	Various embodiments that pertain to oxygen enrichment are described. Oxygen enrichment is shown to allow for independent control of both reformer residence time and the oxygen-to-carbon ratio during reforming. This allows for much better control over the reformer and for significant gains in reformer through-put without negative impacts to reformer performance. Additionally, the use of oxygen enriched reforming is shown to result in enhanced reformer performance, reduced degradation from catalyst poisons (carbon formation and sulfur) and enhanced fuel cell stack performance due to greatly increased hydrogen concentration in the reformate.
FILED	Monday, June 01, 2015
APPL NO	14/726809
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/24 (20130101) Original (OR) Class B01J 2219/24 (20130101) B01J 2219/00065 (20130101) B01J 2219/00069 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/38 (20130101) C01B 13/0251 (20130101) C01B 2203/0227 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101)
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09969115 — Article comprising light absorbent composition to mask visual haze and related method

US 09969115	Sisson et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Aberdeen Proving Ground (APG)
APPLICANT(S)	APG Polytech, LLC (Wilmington, Delaware)
ASSIGNEE(S)	APG Polytech, LLC (Wilmington, Delaware)
INVENTOR(S)	Edwin Andrew Sisson (Medina, Ohio); Arianna Giovannini (Tortona, Italy); Simone Ferrero (Tortona, Italy)
ABSTRACT	A transparent article includes a continuous polyester matrix having at least one incompatible filler dispersed therein. The incompatible filler provides domains in the polyester matrix, each domain having a particular dimension, thus providing a range of dimensions for the domains in the article. To create haze, the dimensions are within the range of from about 380 nm to about 720 nm. Once the range of dimensions is determined, a light absorbent composition can be found which absorbs light at a range of wavelengths that at least substantially covers the range of dimensions of the domains. In doing so, it has been found that the haze of the article can be substantially masked. Method for producing the article and for masking the haze are also provided.
FILED	Tuesday, January 17, 2017
APPL NO	15/407710
ART UNIT	1782 — Miscellaneous Articles, Stock Material
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 49/06 (20130101) Original (OR) Class B29C 2049/069 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 1/02 (20130101) B32B 27/08 (20130101) B32B 27/18 (20130101) B32B 27/20 (20130101) B32B 27/34 (20130101) B32B 27/36 (20130101) B32B 27/302 (20130101) B32B 27/304 (20130101) B32B 27/306 (20130101) B32B 27/365 (20130101) B32B 2250/02 (20130101) B32B 2307/412 (20130101) B32B 2307/4026 (20130101) B32B 2307/7242 (20130101) B32B 2327/06 (20130101) B32B 2331/04 (20130101) B32B 2367/00 (20130101) B32B 2369/00 (20130101) B32B 2377/00 (20130101) B32B 2439/00 (20130101) B32B 2439/60 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 1/0207 (20130101) B65D 1/0215 (20130101) B65D 25/54 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/0033 (20130101) C08K 5/005 (20130101) C08K 5/0041 (20130101) C08K 2201/008 (20130101) Compositions of Macromolecular Compounds C08L 67/02 (20130101) C08L 67/02 (20130101) C08L 77/06 (20130101) C08L 77/10 (20130101) C08L 2201/10 (20130101) C08L 2203/10 (20130101) C08L 2666/20 (20130101) Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) G02B 5/22 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/25 (20150115) Y10T 428/139 (20150115) Y10T 428/1352 (20150115) Y10T 428/1372 (20150115) Y10T 428/1379 (20150115) Y10T 428/1383 (20150115) Y10T 428/1393 (20150115) Y10T 428/1397 (20150115) Y10T 428/31736 (20150401) Y10T 428/31786 (20150401)
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09969134 — Nanopatterned biopolymer optical device and method of manufacturing the same

US 09969134	Kaplan et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	David Kaplan (Concord, Massachusetts); Fiorenzo Omenetto (Wakefield, Massachusetts); Brian Lawrence (New York, New York); Mark Cronin-Golomb (Reading, Massachusetts)
ASSIGNEE(S)	Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S)	David Kaplan (Concord, Massachusetts); Fiorenzo Omenetto (Wakefield, Massachusetts); Brian Lawrence (New York, New York); Mark Cronin-Golomb (Reading, Massachusetts)
ABSTRACT	A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film on the substrate, where the solidified biopolymer film is formed with a surface having a nanopattern thereon. In another embodiment, the method also includes annealing the solidified biopolymer film. A nanopatterned biopolymer optical device includes a solidified biopolymer film with a surface having a nanopattern is also provided.
FILED	Monday, November 05, 2007
APPL NO	12/513394
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 1/00 (20130101) C08L 3/00 (20130101) C08L 5/00 (20130101) C08L 89/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) G02B 1/04 (20130101) G02B 1/04 (20130101) G02B 1/04 (20130101) G02B 1/04 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24479 (20150115)
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09969504 — Automated multi-plane propulsion system

US 09969504	Davis et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Raymond Lawson Davis (Kanagawa-Ken, Japan); Patrick Alan Livesay (Suffolk, Virginia)
ABSTRACT	Provided here is a UAV launcher generally comprising a launcher frame, first rail guide, second rail guide, and a conveyor system comprising a conveyor, where the first rail guide, second rail guide, and some portion of the conveyor are typically substantially parallel, and where the first and second rail guide typically extend beyond the driver wheel of the conveyor system in a launching direction. The driver wheel and driven wheel of the conveyor system rotate on axes generally perpendicular to the first and second rail guide. A DC motor is coupled to the driver wheel and generates rotation of the driver wheel, and correspondingly governs the linear velocity of the conveyor. A motor controller is configured to control the RPM of the DC motor using a motor speed profile and a wedge interface coupled to the transmission drive motivates a loaded UAV to a launching velocity such that the UAV achieves airborne operation.
FILED	Monday, March 28, 2016
APPL NO	15/082255
ART UNIT	3647 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/08 (20130101) B64C 2201/021 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/04 (20130101) Original (OR) Class
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09969610 — Wafer level MEMS package including dual seal ring

US 09969610	Diep et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	RAYTHEON COMPANY (Waltham, Massachusetts)
INVENTOR(S)	Buu Q. Diep (Murphy, Texas); Adam M. Kennedy (Santa Barbara, California); Thomas Allan Kocian (Dallas, Texas); Mark Lamb (Goleta, California)
ABSTRACT	A microelectromechanical systems (MEMS) package includes a substrate extending between a first pair of outer edges to define a length and a second pair of outer edges to define a width. A seal ring assembly is disposed on the substrate and includes at least one seal ring creating a first boundary point adjacent to at least one MEMS device and a second boundary point adjacent at least one of the outer edges. The package further includes a window lid on the seal ring assembly to define a seal gap containing the at least one MEMS device. The seal ring assembly anchors the window lid to the substrate at the second boundary point such that deflection of the window lid into the seal gap is reduced.
FILED	Thursday, January 26, 2017
APPL NO	15/416206
ART UNIT	2812 — Semiconductors/Memory
CURRENT CPC	Microstructural Devices or Systems, e.g Micromechanical Devices B81B 7/0058 (20130101) Original (OR) Class B81B 2201/04 (20130101) B81B 2201/0207 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00269 (20130101) B81C 2203/019 (20130101) B81C 2203/0109 (20130101) B81C 2203/0118 (20130101) B81C 2203/0145 (20130101)
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09969759 — Duplex-selective organometallic DNA intercalators

US 09969759	Mirkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE) Division of Materials Research (DMR)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); Chad M. Shade (Chicago, Illinois); Robert D. Kennedy (Midland, Michigan); Jessica Lynn Rouge (Evanston, Illinois); Soyoung E. Seo (Evanston, Illinois); Mary X. Wang (Evanston, Illinois)
ABSTRACT	Disclosed herein are organometallic complexes and methods of using the same in detecting double stranded DNA or RNA, selectively over single stranded DNA or RNA.
FILED	Friday, May 22, 2015
APPL NO	15/312221
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0053 (20130101) Original (OR) Class Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 23/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6816 (20130101) C12Q 2563/173 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44726 (20130101) G01N 27/44747 (20130101) G01N 33/582 (20130101) G01N 33/587 (20130101) G01N 33/5308 (20130101)
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09969905 — Transient liquid phase (TLP) bonding of nickel based alloys by forming an aluminum-titanium coating and subsequent heat treatment

US 09969905	Dunand et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	David C. Dunand (Evanston, Illinois); Dinc Erdeniz (Evanston, Illinois)
ABSTRACT	Certain aspects of the invention provides a transient liquid phase (TLP) bonding structure, including Ni based alloys and a TLP bonded layer formed by pack cementation on the Ni based alloys using a pack composition. In one embodiment, the pack composition includes 57 wt. % of aluminum oxide powder, 30 wt. % of Ti powder, 10 wt. % of Ni-50 wt. % Al alloy powder and 3 wt. % of ammonium chloride powder. The Ni based alloys may be Ni-20 wt. % Cr alloys. In certain embodiments, pack cementation is performed on the Ni based alloys under argon for an hour using the pack composition to form a coating. Then the structure is sonicated in acetone for 2 hours, and then annealed under vacuum at about 1200° C. for 2 days to form the TLP bonding structure, which has a uniform γ′ phase distribution with identical compositions and properties at its bonding regions.
FILED	Thursday, January 08, 2015
APPL NO	14/592503
ART UNIT	1784 — Miscellaneous Articles, Stock Material
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/12 (20130101) B32B 15/04 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 1/00 (20130101) Original (OR) Class Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 12/00 (20130101) Technical Subjects Covered by Former US Classification Y10T 442/3463 (20150401)
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09969963 — Methods and apparatus for cell culture array

US 09969963	Hung et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Paul J. Hung (Berkeley, California); Philip J. Lee (Alameda, California); Luke P. Lee (Orinda, California)
ABSTRACT	Methods and systems are described for improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
FILED	Wednesday, September 16, 2015
APPL NO	14/855584
ART UNIT	1799 — Miscellaneous Articles, Stock Material
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 3/502761 (20130101) B01L 2200/027 (20130101) B01L 2200/0647 (20130101) B01L 2200/0689 (20130101) B01L 2300/0627 (20130101) B01L 2300/0816 (20130101) B01L 2400/086 (20130101) B01L 2400/088 (20130101) B01L 2400/0487 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/34 (20130101) C12M 29/06 (20130101) C12M 29/10 (20130101) C12M 41/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101)
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09969964 — Disease-on-a-chip

US 09969964	Lelievre et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
INVENTOR(S)	Sophie Andree Lelievre (West Lafayette, Indiana); Pierre-Alexandre Vidi (West Lafayette, Indiana); James Francis Leary (West Lafayette, Indiana); Teimour Maleki-Jafarabadi (Thousand Oaks, California)
ABSTRACT	The invention generally relates to a cell culture system for coculturing non-neoplastic and neoplastic cells on a planar member which more faithfully mimics the in vivo geometry of a lumen or a cavity.
FILED	Friday, December 19, 2014
APPL NO	14/577326
ART UNIT	1799 — Miscellaneous Articles, Stock Material
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 23/04 (20130101) C12M 23/12 (20130101) C12M 23/20 (20130101) Original (OR) Class
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09970013 — Rapid in situ testing for environmental contamination

US 09970013	Eberly et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Jed O. Eberly (Vicksburg, Mississippi); Fiona Crocker (Clinton, Mississippi); Karl J. Indest (Ridgeland, Mississippi)
ASSIGNEE(S)	The United States of America as Represented by The Secretary of The Army (Alexandria, Virginia)
INVENTOR(S)	Jed O. Eberly (Vicksburg, Mississippi); Fiona Crocker (Clinton, Mississippi); Karl J. Indest (Ridgeland, Mississippi)
ABSTRACT	The present invention provides synthetic RNA aptamers that bind RDX. In various embodiments, the synthetic RNA aptamers may include one or more aptamers selected from the group consisting of SEQ ID 1-12. The synthetic RNA aptamers that bind RDX provide an inexpensive, in situ method for testing for RDX, which may be used for both soil and water samples.
FILED	Wednesday, June 03, 2015
APPL NO	14/729732
ART UNIT	1674 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class C12N 15/1048 (20130101) C12N 2310/16 (20130101) C12N 2320/13 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/49 (20130101) G01N 27/301 (20130101) G01N 27/3277 (20130101)
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09970040 — Engineering DNA assembly in vivo and methods of making and using the reverse transcriptase technology

US 09970040	Elbaz et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Johann Elbaz (Brookline, Massachusetts); Christopher Voigt (Belmont, Massachusetts)
ABSTRACT	Cells that can synthesize oligonucleotides in vivo to produce a nucleic acid nanostructure are described. Methods for producing oligonucleotide nanostructures for use in regulating gene expression and altering biological pathways are provided. Methods of performing multiplex automated genome editing (MAGE) are also provided.
FILED	Friday, September 26, 2014
APPL NO	14/498116
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1276 (20130101) C12N 15/1096 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class
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09970049 — Use of modular nucleic acid scaffolds to create nanoscale energy harvesting and focusing arrays

US 09970049	Buckhout-White et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Susan Buckhout-White (Silver Spring, Maryland); Mario Ancona (Alexandria, Virginia); Ellen R. Goldman (Germantown, Maryland); Igor L. Medintz (Springfield, Virginia); Joseph S. Melinger (Oakton, Virginia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Susan Buckhout-White (Silver Spring, Maryland); Mario Ancona (Alexandria, Virginia); Ellen R. Goldman (Germantown, Maryland); Igor L. Medintz (Springfield, Virginia); Joseph S. Melinger (Oakton, Virginia)
ABSTRACT	The invention relates to a nanoscale antenna including a nucleic acid scaffold having a structure selected from the group consisting of a Holliday junction, a star, and a dendrimer; and a plurality of fluorophores attached to the scaffold and configured as a FRET cascade comprising at least three different types of fluorophores, arranged with (a) a plurality of initial donor fluorophores fixed in exterior positions on the structure, (b) a terminal acceptor fluorophore fixed in a central position on the structure, and (c) a plurality of intermediate fluorophores fixed in positions on the scaffold between the initial acceptor fluorophores and the terminal acceptor fluorophores.
FILED	Tuesday, April 14, 2015
APPL NO	14/685836
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) Original (OR) Class C12Q 1/6818 (20130101) C12Q 2563/155 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101)
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09970056 — Methods and kits for diagnosing, prognosing and monitoring parkinson's disease

US 09970056	Potashkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC)
APPLICANT(S)	Rosalind Franklin University of Medicine and Science (North Chicago, Illinois)
ASSIGNEE(S)	Rosalind Franklin University of Medicine and Science (North Chicago, Illinois)
INVENTOR(S)	Judith Ann Potashkin (North Chicago, Illinois); Jose Alfredo Santiago (North Chicago, Illinois)
ABSTRACT	Network-based meta-analysis of four independent microarray studies identified the hepatocyte nuclear factor (HNF4A), a transcription factor associated with gluconeogenesis and diabetes, as a central regulatory hub gene upregulated in blood of PD patients. In parallel, the polypyrimidine tract binding protein 1 (PTBP1), involved in the stabilization and mRNA translation of insulin, was identified as the most downregulated gene. Using both markers, PD patients were classified with 90% sensitivity and 80% specificity. Longitudinal performance analysis demonstrated that relative abundance of HNF4A and PTBP1 mRNAs significantly decreased and increased, respectively, in PD patients during 3 years follow up period. The inverse regulation of HNF4A and PTBP1 provides a molecular rationale for the altered insulin signaling observed in PD patients. The longitudinally dynamic biomarkers identified in this study may be useful for monitoring disease-modifying therapies for PD.
FILED	Wednesday, September 30, 2015
APPL NO	14/870960
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101)
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09970102 — Energy release using tunable reactive materials

US 09970102	Cabral, Jr. et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Cyril Cabral, Jr. (Mahopac, New York); Gregory M. Fritz (Acton, Massachusetts); Kenneth P. Rodbell (Sandy Hook, Connecticut)
ABSTRACT	A reactive material stack with tunable ignition temperatures is provided by inserting a barrier layer between layers of reactive materials. The barrier layer prevents the interdiffusion of the reactive materials, thus a reaction between reactive materials only occurs at an elevated ignition temperature when a certain energy threshold is reached.
FILED	Monday, February 08, 2016
APPL NO	15/017944
ART UNIT	1783 — Miscellaneous Articles, Stock Material
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/22 (20130101) C23C 16/34 (20130101) Original (OR) Class C23C 16/44 (20130101)
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09970126 — Production of free-standing crystalline material layers

US 09970126	Molnar
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Richard J. Molnar (Harvard, Massachusetts)
ABSTRACT	Herein is provided a growth structure for forming a free-standing layer of crystalline material having at least one crystallographic symmetry. The growth structure includes a host substrate and a separation layer disposed on the host substrate for growth of a layer of the crystalline material thereon. The separation layer has a separation layer thickness, and is mechanically weaker than the host substrate and the crystalline material. An array of apertures is in the separation layer, each aperture extending through the separation layer thickness.
FILED	Thursday, February 20, 2014
APPL NO	14/770194
ART UNIT	1713 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/105 (20130101) C30B 9/04 (20130101) C30B 23/025 (20130101) Original (OR) Class C30B 25/20 (20130101) C30B 25/183 (20130101) C30B 29/36 (20130101) C30B 29/40 (20130101) C30B 29/406 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/02458 (20130101) H01L 21/02639 (20130101) H01L 31/03044 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/544 (20130101)
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09970127 — Method and apparatus for producing large, single-crystals of aluminum nitride

US 09970127	Schowalter et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Research Laboratory (AFRL) Department of the Navy (DON) Office of Naval Research (ONR) Missile Defense Agency (MDA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Crystal IS, Inc. (Green Island, New York)
ASSIGNEE(S)	CRYSTAL IS, INC. (Green Island, New York)
INVENTOR(S)	Leo Schowalter (Latham, New York); Glen A. Slack (Scotia, New York); Juan Carlos Rojo (South Beach, New York); Robert T. Bondokov (Watervliet, New York); Kenneth E. Morgan (Castleton, New York); Joseph A. Smart (Mooresville, North Carolina)
ABSTRACT	Bulk single crystals of AlN having a diameter greater than about 25 mm and dislocation densities of about 10,000 cm⁻²or less and high-quality AlN substrates having surfaces of any desired crystallographic orientation fabricated from these bulk crystals.
FILED	Monday, August 08, 2016
APPL NO	15/231141
ART UNIT	1785 — Miscellaneous Articles, Stock Material
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 11/003 (20130101) C30B 23/00 (20130101) C30B 23/025 (20130101) C30B 25/10 (20130101) C30B 25/14 (20130101) C30B 25/16 (20130101) Original (OR) Class C30B 25/20 (20130101) C30B 29/403 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/02389 (20130101) H01L 21/02458 (20130101) H01L 21/02634 (20130101) H01L 29/04 (20130101) H01L 29/32 (20130101) H01L 29/205 (20130101) H01L 29/0657 (20130101) H01L 29/2003 (20130101) H01L 29/7787 (20130101) H01L 29/66462 (20130101) H01L 33/12 (20130101) H01L 33/025 (20130101) H01L 33/0075 (20130101) H01L 33/325 (20130101) H01L 2924/00 (20130101) H01L 2924/0002 (20130101) H01L 2924/0002 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/21 (20150115)
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09970222 — Compliant hinge for membrane-like structures

US 09970222	Ardelean et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Emil V. Ardelean (Albuquerque, New Mexico); Sungeun K. Jeon (Albuquerque, New Mexico); Jeremy A. Banik (Albuquerque, New Mexico)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Air Force (Washington, District of Columbia)
INVENTOR(S)	Emil V. Ardelean (Albuquerque, New Mexico); Sungeun K. Jeon (Albuquerque, New Mexico); Jeremy A. Banik (Albuquerque, New Mexico)
ABSTRACT	A compliant hinge for deployable membrane-like structures and other applications is provided. The compliant hinge generally includes a flexible intermediate portion having one or more enclosed contours connected by inner longitudinal segments along a longitudinal axis of symmetry. The enclosed contours are resiliently deformable in response to an in-plane load, including tension and shear forces. The compliant hinge allows for rotation, bending, and extension, and can interconnect rigid panels in tensioned precision structures and other applications.
FILED	Wednesday, December 17, 2014
APPL NO	14/573288
ART UNIT	3677 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Hinges or Suspension Devices for Doors, Windows or Wings E05D 1/00 (20130101) E05D 1/02 (20130101) Original (OR) Class E05D 9/00 (20130101) E05D 9/005 (20130101) Indexing Scheme Relating to Hinges or Other Suspension Devices for Doors, Windows or Wings and Devices for Moving Wings into Open or Closed Position, Checks for Wings and Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing E05Y 2800/344 (20130101) Technical Subjects Covered by Former US Classification Y10T 16/525 (20150115)
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09970307 — Turbine nozzles with slip joints impregnated by oxidation-resistant sealing material and methods for the production thereof

US 09970307	Kanjiyani et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	HONEYWELL INTERNATIONAL INC. (Morristown, New Jersey)
ASSIGNEE(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
INVENTOR(S)	Shezan Kanjiyani (Glendale, Arizona); Bradley Reed Tucker (Chandler, Arizona); Natalie Wali (Chandler, Arizona); Daniel Hicks (Piedmont, South Carolina); Bill Macelroy (Greer, South Carolina)
ABSTRACT	Embodiments of a turbine nozzle having slip joints impregnated by an oxidation-resistant sealing material are provided, as are embodiments of methods for the manufacture of turbine nozzles. In one embodiment, the method includes providing a support ring, a slip joint ring substantially concentric with the support ring and radially spaced apart therefrom, and a plurality of vanes fixedly coupled to the support ring. The plurality of vanes extends radially from the support ring into a plurality of circumferentially-spaced slots provided in the slip joint ring to form a plurality of slip joints therewith. The plurality of slip joints are impregnated with a silicon-modified aluminide sealing material. The silicon-modified aluminide sealing material impedes gas flow into the radial slip joints during operation of the turbine nozzle, while also fracturing to permit relative radial movement between the plurality of vanes and the slip joint ring along the plurality of slip joints.
FILED	Wednesday, March 19, 2014
APPL NO	14/219622
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0018 (20130101) B23K 2201/001 (20130101) Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/04 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/28 (20130101) F01D 9/041 (20130101) F01D 9/042 (20130101) F01D 11/00 (20130101) F01D 11/005 (20130101) Original (OR) Class F01D 17/162 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2300/182 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/673 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49321 (20150115)
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09970315 — Movable vane control system

US 09970315	DiVincenzo et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Hamilton Sundstrand Corporation (Charlotte, North Carolina)
ASSIGNEE(S)	HAMILTON SUNDSTRAND CORPORATION (Charlotte, North Carolina)
INVENTOR(S)	Gregory DiVincenzo (Wethersfield, Connecticut); Bhupindar Singh (West Hartford, Connecticut); Francis P. Marocchini (Somers, Connecticut)
ABSTRACT	A movable vane control system is disclosed for use with a gas turbine engine having a turbine axis of rotation. The system includes a plurality of rotatable turbine vanes in a gas flow path within a turbine case of the gas turbine engine. A first vane position sensor having a first distance sensor is configured to sense the distance between the first distance sensor and a surface portion of a first of said plurality of vanes or a first movable target connected to the first vane. Additionally, the first distance sensor, the first vane surface portion, the first movable target, or a combination thereof is configured to provide a variable distance between the first distance sensor and the first vane surface portion or first movable target that varies as a function of a position of the first vane.
FILED	Thursday, February 12, 2015
APPL NO	14/621009
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/041 (20130101) F01D 17/02 (20130101) F01D 17/162 (20130101) Original (OR) Class F01D 21/003 (20130101) Non-positive-displacement Pumps F04D 27/001 (20130101) F04D 27/002 (20130101) F04D 29/563 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2250/25 (20130101)
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09970321 — Housing support nut connection

US 09970321	Nguyenloc et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
ASSIGNEE(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Fred Nguyenloc (Plainville, Connecticut); Leslie C. Kurz (Hebron, Connecticut)
ABSTRACT	A housing connection includes a first housing defining a first housing compartment with a first set of threads defined circumferentially around the first housing. A second housing defines a second housing compartment therein. The second housing includes an engagement tab configured for engagement with the first housing. A retention nut defines a second set of threads circumferentially around the retention nut. The first and second sets of threads are engaged together and clamp the engagement tab of the second housing between the first housing and the retention nut ring.
FILED	Monday, November 24, 2014
APPL NO	14/552176
ART UNIT	3679 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/162 (20130101) Original (OR) Class F01D 25/243 (20130101)
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09970480 — Periscope universal hull packing

US 09970480	Naser
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Mark M. Naser (Audobon, Pennsylvania)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Mark M. Naser (Audobon, Pennsylvania)
ABSTRACT	An embodiment of an inventive periscope hull packing system includes a sleeve, a first ring, a first spring-loaded hull seal, a second ring, a second spring-loaded hull seal, and a gland. The first ring is below the sleeve. The first spring-loaded hull seal is below the first ring. The second ring is below the first spring-loaded hull seal. The second spring-loaded hull seal is below the second ring. The gland and the second spring-loaded hull seal, which is housed by the gland, are below the second ring. The sleeve and the gland each have, on the inside circumference, a composite lining affording a lubricious surface for contacting the periscope. Each composite lining is composed of a resinous matrix and a filler lubricant (such as particles or short discontinuous fibers of polytetrafluoroethylene). Each spring-loaded hull seal is characterized by an elastomeric shell and an elastomeric O-ring spring for energizing the shell.
FILED	Tuesday, April 30, 2013
APPL NO	13/874130
ART UNIT	3675 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/38 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 17/14 (20130101) Original (OR) Class F16C 33/74 (20130101)
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09970766 — Platform-mounted artificial vision system

US 09970766	Baumgartner et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Dustin D. Baumgartner (Ellicott, Maryland); Bruce J. Schachter (Clarksville, Maryland); Kathryn B. Stewart (Ellicott City, Maryland); Michael M. Becker (Columbia, Maryland)
ASSIGNEE(S)	Northrop Grumman Systems Corporation (Falls Church, Virginia)
INVENTOR(S)	Dustin D. Baumgartner (Ellicott, Maryland); Bruce J. Schachter (Clarksville, Maryland); Kathryn B. Stewart (Ellicott City, Maryland); Michael M. Becker (Columbia, Maryland)
ABSTRACT	One embodiment includes an artificial vision system mounted on a platform. The system includes an image system comprising a video source that is configured to capture a plurality of sequential images. The image system also includes an image processing system configured, via at least one processor, to process the plurality of sequential images to calculate situational awareness (SA) data with respect to each of the plurality of sequential images and to convert the processed plurality of sequential images to visible images. The system further includes a video display system configured to display the visible images associated with the processed plurality of sequential images and to visibly identify the SA data relative to the platform.
FILED	Monday, September 30, 2013
APPL NO	14/041849
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/165 (20130101) Original (OR) Class G01C 23/00 (20130101) Image Data Processing or Generation, in General G06T 5/003 (20130101) G06T 5/50 (20130101) G06T 2207/10028 (20130101) G06T 2207/10048 (20130101) G06T 2207/20201 (20130101) G06T 2207/30261 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) H04N 5/76 (20130101) H04N 5/144 (20130101) H04N 5/23229 (20130101) H04N 5/23258 (20130101) H04N 5/23267 (20130101) H04N 5/23293 (20130101)
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09970821 — Characterization of spectral emissivity via thermal conductive heating and in-situ radiance measurement using a low-e mirror

US 09970821	Cook et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Steven F. Cook (Tucson, Arizona); Colton L. Noble (Vail, Arizona); Justan V. Forsyth (Tucson, Arizona)
ABSTRACT	A high SNR in-situ measurement of sample radiance in a low-temperature ambient environment is used to accurately characterize sample emissivity for transmissive, low-emissivity samples. A low-e mirror is positioned behind the sample such that the sample and low-e mirror overfill the field-of-view (FOV) of the radiometer. The sample is heated via thermal conduction in an open environment. Thermal conduction heats the sample without raising the background radiance appreciably. The low-e mirror presents both a low emission background against which to measure the sample radiance and reflects radiance from the back of the sample approximately doubling the measured signal. The low-e mirror exhibits a reflectance of at least 90% and preferably greater than 98% and an emissivity of at most 7.5% and preferably less than 2% over the spectral and temperature ranges at which the sample emissivity is characterized.
FILED	Thursday, April 16, 2015
APPL NO	14/688617
ART UNIT	2853 — Printing/Measuring and Testing
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/00 (20130101) G01J 5/0003 (20130101) Original (OR) Class G01J 5/0887 (20130101)
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09970861 — Wide-area real-time method for detecting foreign fluids on water surfaces

US 09970861	Chenault
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Polaris Sensor Technologies, Inc. (Huntsville, Alabama)
ASSIGNEE(S)	Polaris Sensor Technologies, Inc. (Huntsville, Alabama)
INVENTOR(S)	David B. Chenault (Huntsville, Alabama)
ABSTRACT	A method using Infrared Imaging Polarimetry for detecting the presence of foreign fluids on water comprises estimating an expected polarization response for a foreign fluid desired to be detected. Oil from an oil spill is one such foreign fluid. An optimal position of a polarimeter to take images of the water's surface is determined from the expected polarization response. The polarimeter is positioned at the optimal position and records raw image data of the water's surface to obtain polarized images of the area. The polarized images are corrected, and IR and polarization data products are computed. The IR and polarization data products are converted to multi-dimensional data set to form multi-dimensional imagery. Contrast algorithms are applied to the multi-dimensional imagery to form enhanced contrast images, from which foreign fluids can be automatically detected.
FILED	Thursday, December 22, 2016
APPL NO	15/387901
ART UNIT	2884 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) Original (OR) Class G01N 2021/1793 (20130101)
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09970877 — SERS detection system for chemical particulates and low vapor pressure chemicals

US 09970877	Ewing et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Kenneth J. Ewing (Edgewood, Maryland); Jasbinder S. Sanghera (Ashburn, Virginia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Kenneth J. Ewing (Edgewood, Maryland); Jasbinder S. Sanghera (Ashburn, Virginia)
ABSTRACT	A method for detecting chemical aerosols and particulates on a surface by contacting a sample with a Surface Enhanced Raman Spectroscopy (SERS) substrate where the sample is an aerosol or a particulate on a surface, encapsulating the SERS substrate with the sample, heating the encapsulated sample so it vaporizes inside the encapsulation, cooling the vaporized sample so it deposits onto the SERS substrate, and irradiating the SERS substrate to collect a SERS spectrum of the sample. Also disclosed is the related system for detecting chemical aerosols and particulates on a surface.
FILED	Thursday, March 13, 2014
APPL NO	14/207724
ART UNIT	2877 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 21/658 (20130101) Original (OR) Class G01N 2001/4027 (20130101)
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09970932 — Non-covalent patterned chemical features and use thereof in MALDI-based quality control

US 09970932	Woodbury et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S)	Neal Woodbury (Tempe, Arizona); Stephen Johnston (Tempe, Arizona); Zhan Gong Zhao (Tuscon, Arizona); Matthew Greving (Phoenix, Arizona)
ABSTRACT	The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
FILED	Friday, March 14, 2014
APPL NO	14/773751
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54366 (20130101) Original (OR) Class
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09971055 — Constant phase

US 09971055	Heinz et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Daniel Charles Heinz (Perry Hall, Maryland); Adam William Melber (Churchville, Maryland); Thomas Albert Burst (Chapel Hill, North Carolina); Michael Leonard Brennan (Howell, New Jersey); Michael Steer (Raleigh, North Carolina)
ABSTRACT	Various embodiments are described that relate to a loop with a constant phase. The loop can function as an antenna and be used in object detection. A current source can be used to power the loop such that the loop produces a magnetic field and electric field. The magnetic field can be powerful enough to detect a dielectric while the electric field is so small that it does not interfere with nearby communication equipment. Thus, detection can occur without disruption of other important devices.
FILED	Monday, April 10, 2017
APPL NO	15/483170
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/10 (20130101) Original (OR) Class G01V 3/165 (20130101)
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09971063 — Broadband metamaterial apparatus, methods, systems, and computer readable media

US 09971063	Smith et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	David R. Smith (Durham, North Carolina); Ruopeng Liu (Shenzhen, China PRC); Qiang Cheng (Nanjing, China PRC); Yao Qin (Stuttgart, Germany); Tie Jun Cui (Nanjing, China PRC)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	David R. Smith (Durham, North Carolina); Ruopeng Liu (Shenzhen, China PRC); Qiang Cheng (Nanjing, China PRC); Yao Qin (Stuttgart, Germany); Tie Jun Cui (Nanjing, China PRC)
ABSTRACT	Broadband metamaterial apparatus, methods, systems, and computer readable media are disclosed, as well as exemplary embodiments that provide cloaking, beam steering, and beam focusing. In one exemplary implementation, a broadband interface structure has a front surface region and a back surface region. The broadband interface structure is arranged to provide electromagnetic energy characteristic of an apparent profile of the back surface region substantially different than an actual profile of the back surface region for electromagnetic energy received at the front surface region.
FILED	Friday, January 15, 2010
APPL NO	12/688656
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/007 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 15/02 (20130101)
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09971071 — Frequency- and amplitude- modulated narrow-band infrared emitters

US 09971071	Caldwell et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Joshua D. Caldwell (Nashville, Tennessee); Virginia D. Wheeler (Alexandria, Virginia); Marc Currie (Washington, District of Columbia); Igor Vurgaftman (Severna Park, Maryland); Jon-paul Maria (Raleigh, North Carolina)
ABSTRACT	IR emission devices comprising an array of polaritonic IR emitters arranged on a substrate, where the emitters are coupled to a heater configured to provide heat to one or more of the emitters. When the emitters are heated, they produce an infrared emission that can be polarized and whose spectral emission range, emission wavelength, and/or emission linewidth can be tuned by the polaritonic material used to form the elements of the array and/or by the size and/or shape of the emitters. The IR emission can be modulated by the induction of a strain into a ferroelectric, a change in the crystalline phase of a phase change material and/or by quickly applying and dissipating heat applied to the polaritonic nanostructure. The IR emission can be designed to be hidden in the thermal background so that it can be observed only under the appropriate filtering and/or demodulation conditions.
FILED	Thursday, October 26, 2017
APPL NO	15/794207
ART UNIT	2881 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 28/24 (20130101) H01L 49/00 (20130101)
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09971226 — Optoelectronic filter and method for signal suppression

US 09971226	Juodawlkis et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Paul W. Juodawlkis (Arlington, Massachusetts); William Loh (Cambridge, Massachusetts); Rajeev J Ram (Arlington, Massachusetts); Siva Yegnanarayanan (Concord, Massachusetts)
ABSTRACT	An optoelectronic filter having at least one input and an output includes a modulator circuit having at least first and second inputs with a first one of the modulator circuit inputs adapted to couple to a respective one of the at least one input of the optoelectronic filter. The modulator circuit receives at least a first radio frequency (RF) signal having a first power level and a second RF signal having a second, different power level at the first one of the modulator circuit inputs and in response thereto generates a modulated signal at an output thereof. The first RF signal is suppressed relative to the second RF signal in the modulated signal. The optoelectronic filter additionally includes a light source adapted to couple to a second one of the modulator circuit inputs. A corresponding method is also provided.
FILED	Thursday, July 31, 2014
APPL NO	14/908589
ART UNIT	2878 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/21 (20130101) G02F 1/035 (20130101) G02F 1/2255 (20130101) Original (OR) Class G02F 2001/212 (20130101)
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09971239 — Silica polymer pen lithography

US 09971239	Mirkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); Keith A. Brown (Newton, Massachusetts); James L. Hedrick, III (Evanston, Illinois)
ABSTRACT	Provided here are hard transparent polymer pen arrays, methods of printing indicia using the same, and methods of preparing the same.
FILED	Friday, October 21, 2016
APPL NO	15/299565
ART UNIT	2854 — Printing/Measuring and Testing
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/402 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class
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09971668 — Method for identifying the performance bounds of a transmit-receive module

US 09971668	Allen et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	Jeffery C. Allen (San Diego, California); Diana Arceo (San Diego, California); John W. Rockway (San Diego, California)
ASSIGNEE(S)	The United States of America as represented by Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Jeffery C. Allen (San Diego, California); Diana Arceo (San Diego, California); John W. Rockway (San Diego, California)
ABSTRACT	A method for identifying performance bounds of a transmit-receive (T/R) module over a bandwidth ƒ_bwhen connected to an antenna, a transmitter, and a receiver all with known reflectance within the bandwidth ƒ_b; measuring a raw T/R module point representing isolation and insertion loss of the T/R module when connected to the antenna, the transmitter, and the receiver without a matching circuit; plotting the raw T/R module point on a performance image graph; using a mathematical representation of a multiport matching circuit that contains no gyrators and comprises a fixed number of capacitors and inductors to approximate a Pareto front comprised of a plurality of Pareto points; and connecting each Pareto point to the raw T/R module point on the performance image graph such that the performance image becomes a visual representation of the performance bounds of a class of multiport matching circuits having capacitors and inductors.
FILED	Wednesday, May 15, 2013
APPL NO	13/894935
ART UNIT	2865 — Printing/Measuring and Testing
CURRENT CPC	Electric Digital Data Processing G06F 11/3409 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 1/521 (20130101) H01Q 1/525 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0278 (20130101)
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09971891 — Methods, systems, and media for detecting covert malware

US 09971891	Bowen et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Multidisciplinary University Research Initiative (MURI) National Science Foundation (NSF)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of the New York (New York, New York)
INVENTOR(S)	Brian M. Bowen (New York, New York); Pratap V. Prabhu (New York, New York); Vasileios P. Kemerlis (New York, New York); Stylianos Sidiroglou (Astoria, New York); Salvatore J. Stolfo (Ridgewood, New Jersey); Angelos D. Keromytis (New York, New York)
ABSTRACT	Methods, systems, and media for detecting covert malware are provided. In accordance with some embodiments, a method for detecting covert malware in a computing environment is provided, the method comprising: receiving a first set of user actions; generating a second set of user actions based on the first set of user actions and a model of user activity; conveying the second set of user actions to an application inside the computing environment; determining whether state information of the application matches an expected state after the second set of user actions is conveyed to the application; and determining whether covert malware is present in the computing environment based at least in part on the determination.
FILED	Tuesday, August 13, 2013
APPL NO	13/965619
ART UNIT	2494 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/56 (20130101) Original (OR) Class G06F 21/566 (20130101) G06F 21/577 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1441 (20130101) H04L 63/1491 (20130101)
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09971910 — Multi-level security domain separation using soft-core processor embedded in an FPGA

US 09971910	Kling et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	RAYTHEON COMPANY (Waltham, Massachusetts)
ASSIGNEE(S)	RAYTHEON COMPANY (Waltham, Massachusetts)
INVENTOR(S)	Matthew T. Kling (Marlborough, Massachusetts); Clark B. Hockenbury (Marlborough, Massachusetts); Jerrold L. Bonn (Marlborough, Massachusetts); Susan F. Bataller (Marlborough, Massachusetts); Mark Veneziano (Marlborough, Massachusetts)
ABSTRACT	A system and method for operating multiple security domains on one circuit card assembly, using a field-programmable gate array (FPGA) with an embedded security domain separation gate providing the MAC between multiple soft-core CPUs also embedded in the FPGA. In one embodiment, the FPGA is segregated into two or more security domains with no data paths between soft-core CPUs in each security domain except through the security domain separation gate. The security domain separation gate applies rules to any information to be transmitted between the security domains to avoid transmission of malicious content and to avoid transmission of information of a certain classification level or type to a security domain at a lower classification level or type.
FILED	Thursday, January 22, 2015
APPL NO	14/603215
ART UNIT	2495 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/74 (20130101) G06F 21/76 (20130101) Original (OR) Class G06F 21/606 (20130101) G06F 2221/2113 (20130101)
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09971965 — Implementing a neural network algorithm on a neurosynaptic substrate based on metadata associated with the neural network algorithm

US 09971965	Amir et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Arnon Amir (Saratoga, California); Rathinakumar Appuswamy (San Jose, California); Pallab Datta (San Jose, California); Myron D. Flickner (San Jose, California); Paul A. Merolla (Palo Alto, California); Dharmendra S. Modha (San Jose, California); Benjamin G. Shaw (San Francisco, California)
ABSTRACT	One embodiment of the invention provides a system for mapping a neural network onto a neurosynaptic substrate. The system comprises a metadata analysis unit for analyzing metadata information associated with one or more portions of an adjacency matrix representation of the neural network, and a mapping unit for mapping the one or more portions of the matrix representation onto the neurosynaptic substrate based on the metadata information.
FILED	Wednesday, March 18, 2015
APPL NO	14/662115
ART UNIT	2129 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/049 (20130101) G06N 3/061 (20130101) Original (OR) Class G06N 3/105 (20130101)
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09972677 — Methods of forming power semiconductor devices having superjunction structures with pillars having implanted sidewalls

US 09972677	Van Brunt et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Cree, Inc. (Durham, North Carolina)
ASSIGNEE(S)	Cree, Inc. (Durham, North Carolina)
INVENTOR(S)	Edward Robert Van Brunt (Morrisville, North Carolina); Vipindas Pala (Morrisville, North Carolina); Lin Cheng (Chapel Hill, North Carolina); Daniel J. Lichtenwalner (Raleigh, North Carolina)
ABSTRACT	Methods of forming a power semiconductor device are provided in which a semiconductor drift layer that is doped with impurities having a first conductivity type is formed on a semiconductor substrate. A portion of the semiconductor drift layer is removed to form a recessed region in the semiconductor drift layer and to define a first semiconductor pillar. Impurities having a second conductivity type that is opposite the first conductivity type are implanted into a first sidewall of the semiconductor drift layer that is exposed by the recessed region to convert a portion of the first semiconductor pillar into a second semiconductor pillar. A third semiconductor pillar is formed in the recessed region.
FILED	Monday, October 31, 2016
APPL NO	15/338479
ART UNIT	2819 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/047 (20130101) H01L 21/0475 (20130101) H01L 29/045 (20130101) H01L 29/0619 (20130101) H01L 29/0634 (20130101) Original (OR) Class H01L 29/0684 (20130101) H01L 29/0692 (20130101) H01L 29/872 (20130101) H01L 29/1095 (20130101) H01L 29/1608 (20130101) H01L 29/6606 (20130101)
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09972687 — High quality vanadium dioxide films

US 09972687	Eom et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Chang-Beom Eom (Madison, Wisconsin); Daesu Lee (Madison, Wisconsin)
ABSTRACT	Layers of high quality VO₂and methods of fabricating the layers of VO₂are provided. The layers are composed of a plurality of connected crystalline VO₂domains having the same crystal structure and the same epitaxial orientation.
FILED	Tuesday, March 21, 2017
APPL NO	15/464536
ART UNIT	2818 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02414 (20130101) H01L 21/02483 (20130101) H01L 21/02565 (20130101) H01L 29/24 (20130101) Original (OR) Class H01L 29/78 (20130101) H01L 29/1033 (20130101) H01L 29/1079 (20130101) H01L 29/66969 (20130101) H01L 45/146 (20130101) H01L 45/1206 (20130101) Pulse Technique H03K 17/51 (20130101) H03K 17/687 (20130101)
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09972799 — Gate-tunable p-n heterojunction diode, and fabrication method and application of same

US 09972799	Hersam et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Mark C. Hersam (Wilmette, Illinois); Deep M. Jariwala (Evanston, Illinois); Vinod K. Sangwan (Evanston, Illinois)
ABSTRACT	A method of fabricating a diode includes forming a first semiconductor layer having a first portion and a second portion extending from the first portion on a substrate; forming first and second electrodes on the substrate, the first electrode extending over and being in contact with the first portion of the first semiconductor layer; forming an insulting film to cover the first electrode and the first portion of the first semiconductor layer; and forming a second semiconductor layer having a first portion and a second portion extending from the first portion on the substrate. The second portion of the second semiconductor layer overlapping with the second portion of the first semiconductor layer to define a vertically stacked heterojunction therewith. The first portion of the second semiconductor layer extending over and being in contact with the second electrode. Each of the first and second semiconductor layers includes an atomically thin semiconductor.
FILED	Wednesday, September 14, 2016
APPL NO	15/265166
ART UNIT	2894 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 51/0048 (20130101) H01L 51/102 (20130101) H01L 51/0587 (20130101) Original (OR) Class
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09972961 — Two-ended pumping of a composite fiber optic amplifier

US 09972961	Sipes, Jr. et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	OPTICAL ENGINES, INC. (Colorado Springs, Colorado)
ASSIGNEE(S)	OPTICAL ENGINES, INC. (Colorado Springs, Colorado)
INVENTOR(S)	Donald L. Sipes, Jr. (Colorado Springs, Colorado); Jason D. Tafoya (Colorado Springs, Colorado); Daniel Scott Schulz (Colorado Springs, Colorado)
ABSTRACT	Exemplary embodiments of the disclosure include a fiber optic amplifier system and a fiber optic oscillator system having a first stage, comprising a first core fiber having a first core diameter and a first cladding size; a second stage, comprising a second core fiber having a second core diameter and a second cladding size; and a double mode adapter connecting the first stage to the second stage, wherein the double mode adapter is configured to provide transitions for the cores and the claddings of the first and second core fibers.
FILED	Friday, June 24, 2016
APPL NO	15/192389
ART UNIT	3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/14 (20130101) G02B 6/024 (20130101) G02B 6/02009 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0941 (20130101) H01S 3/1618 (20130101) H01S 3/06712 (20130101) H01S 3/06741 (20130101) H01S 3/06758 (20130101) H01S 3/094007 (20130101) H01S 3/094011 (20130101) Original (OR) Class H01S 2301/03 (20130101)
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09972962 — Tuning multi-input complex dynamic systems using sparse representations of performance and extremum-seeking control

US 09972962	Kutz et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Mathematical Sciences (DMS)
APPLICANT(S)	University of Washington (Seattle, Washington)
ASSIGNEE(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington)
INVENTOR(S)	Jose Nathan Kutz (Seattle, Washington); Steven Brunton (Seattle, Washington); Xing Fu (Seattle, Washington)
ABSTRACT	Systems and methods for tuning multi-input complex dynamic systems in order to automatically obtain optimal performance are provided. Training is performed by measuring performance of the complex system using an objective function for a sparse sampling of input values over a variety of dynamic regimes. A sparse representation of the performance for each dynamic regime is stored in a library. At run-time, performance is measured and matched to a sparse representation in the library, and the complex system is configured with the optimal input values associated with the matching sparse representation from the library. Performance may then be optimized using an extremum-seeking controller. In some embodiments, the disclosed techniques are applied to a self-tuning mode-locked laser. In some embodiments, the disclosed techniques are applied to other complex systems such as phased array antennas and neurostimulation systems.
FILED	Tuesday, August 11, 2015
APPL NO	14/823944
ART UNIT	2115 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0014 (20130101) H01S 3/139 (20130101) H01S 3/1115 (20130101) Original (OR) Class H01S 3/1305 (20130101) H01S 3/06791 (20130101) H01S 3/10069 (20130101)
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09972963 — Process using a single circular wedge prism for fine alignment of a laser cavity with a single-axis scanning element as the optical Q-switch

US 09972963	Nettleton et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	John E. Nettleton (Fairfax Station, Virginia); Nathaniel L. Hough (Fairfax Station, Virginia)
ABSTRACT	The compact, laser cavity with a single-axis scanning element as the optical Q-switch incorporates all optical components required for a short-pulse laser. These optical components are ‘locked’ into alignment forming an optical laser cavity for diode laser or flash lamp pumping. The optical laser cavity does not need optical alignment after it is fabricated. Unfortunately, during the alignment process of the optical laser cavity there are small shifts due to the bonding process of the optical elements. These small shifts introduce alignment errors which results in a decrease in output energy and beam quality. The improvement presented adds a single circular wedge prism that corrects these alignment errors returning the output back to its optimum energy output and beam quality.
FILED	Tuesday, April 01, 2014
APPL NO	14/231830
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/106 (20130101) H01S 3/123 (20130101) Original (OR) Class H01S 3/0941 (20130101) H01S 3/08004 (20130101)
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09973291 — Combined signal produced from signal copies

US 09973291	Goodall et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Steven Goodall (Lincoln University, Pennsylvania); Shuguang Chen (Ellicott City, Maryland)
ABSTRACT	Various embodiments are described that relate to a combined signal. A signal can be transmitted from a transmitter and be received by a receiver. The receiver can be an antenna array that comprises multiple individual antenna elements. At least some of these individual elements can receive the transmitted signal at different reception angles and these received signals can be considered signal copies. The reception angle can influence a power level of a signal copy. Multiple signal copies can be combined together into a combined signal that has a greater power level than the individual signal copies used in the combination.
FILED	Thursday, February 18, 2016
APPL NO	15/046542
ART UNIT	2472 — Multiplex and VoIP
CURRENT CPC	Multiplex Communication H04J 1/08 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0058 (20130101)
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09973473 — Methods, systems, and computer readable media for rapid filtering of opaque data traffic

US 09973473	White et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The Regents of the University of Michigan (Ann Arbor, Michigan); SRI International (Menlo Park, California)
ASSIGNEE(S)	THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina)
INVENTOR(S)	Andrew Maxwell White (Chapel Hill, North Carolina); Fabian Monrose (Chapel Hill, North Carolina); Srinivas Krishnan (Berkeley, California); Phillip Andrew Porras (Cupertino, California); Michael Donald Bailey (Ypsilanti, Michigan)
ABSTRACT	Methods, systems, and computer readable media for rapid filtering of opaque data traffic are disclosed. According to one method, the method includes receiving a packet containing a payload. The method also includes analyzing a portion of the payload for determining whether the packet contains compressed or encrypted data. The method further includes performing, if the packet contains compressed or encrypted data, at least one of sending the packet to an opaque traffic analysis engine for analysis, discarding the packet, logging the packet, or marking the packet.
FILED	Wednesday, March 13, 2013
APPL NO	14/387967
ART UNIT	2495 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 63/0245 (20130101) Original (OR) Class H04L 63/1416 (20130101)
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09974008 — Element-centric communication map

US 09974008	May et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Bryan May (Baltimore, Maryland); Robert Shields (Phoenix, Maryland); Jeffrey Boksiner (Cockeysville, Maryland); Glenn Minko (Aberdeen, Maryland)
ABSTRACT	Various embodiments are described that relate to a visualization. A visualization can be produced that relates to a coverage area for an element in the network. A user of this element can read the visualization and make decisions in view of the coverage area. In one instance, the user can read the visualization and select a route of travel such that a likelihood of coverage being lost during travel is relatively small.
FILED	Friday, March 25, 2016
APPL NO	15/080721
ART UNIT	2641 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Wireless Communication Networks H04W 16/22 (20130101) H04W 24/04 (20130101) H04W 48/16 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Department of Energy (DOE)

09968887 — Membrane assisted solvent extraction for rare earth element recovery

US 09968887	Bhave et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Ramesh R. Bhave (Knoxville, Tennessee); Daejin Kim (Knoxville, Tennessee); Eric S. Peterson (Idaho Falls, Idaho)
ABSTRACT	Systems and methods for the recovery of rare earth elements are provided. The systems and methods generally include membrane assisted solvent extraction using permeable hollow fibers having an immobilized organic phase within the pores of the hollow fibers. The permeable hollow fibers are generally in contact with an acidic aqueous feed on one side thereof and a strip solution on another side thereof. The systems and methods generally include the simultaneous extraction and stripping of rare earth elements as a continuous recovery process that is well suited for post-consumer products, end-of-life products, and other recovery sources of rare earth elements.
FILED	Friday, May 29, 2015
APPL NO	14/724985
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Separation B01D 61/246 (20130101) Original (OR) Class B01D 69/08 (20130101) B01D 69/081 (20130101) B01D 71/26 (20130101) B01D 2325/12 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/0005 (20130101) C22B 7/006 (20130101) C22B 59/00 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/234 (20151101)
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09969553 — Hopper apparatuses for processing a bulk solid, and related systems and methods

US 09969553	Westover et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE) Idaho National Laboratory (INL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
INVENTOR(S)	Tyler Lott Westover (Idaho Falls, Idaho); John Chadron Benjamin Ryan (Rexburg, Idaho); Austin Colter Matthews (Salt Lake City, Utah); Sergio Hernandez (Idaho Falls, Idaho)
ABSTRACT	A hopper apparatus comprises a movable wall comprising opposing walls movably connected to a support assembly and oriented at acute angles relative to a central vertical axis of the support assembly, and movement control devices configured and positioned to move the opposing walls along the support assembly to control dimensions of a discharge outlet at least partially defined by converging ends of the opposing walls; a liner assembly comprising liner structures at least partially overlying inner surfaces of the opposing walls and configured to remain at least partially stationary relative to the opposing walls during movement of the opposing walls; and pressure sensors between the inner surfaces of opposing walls and portions of the liner structures thereover. A bulk solids processing system and a method of processing a bulk solid are also described.
FILED	Friday, August 12, 2016
APPL NO	15/235895
ART UNIT	3754 — Fluid Handling and Dispensing
CURRENT CPC	Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 11/20 (20130101) B65G 11/026 (20130101) B65G 11/166 (20130101) Original (OR) Class B65G 11/186 (20130101) B65G 43/08 (20130101) B65G 47/19 (20130101) B65G 2201/04 (20130101) B65G 2203/042 (20130101) Weighing G01G 13/024 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

09969645 — Method for sealing an oxygen transport membrane assembly

US 09969645	Gonzalez et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Javier E. Gonzalez (East Amherst, New York); Arthur F. Grant (Amherst, New York)
ASSIGNEE(S)	PRAXAIR TECHNOLOGY, INC. (Danbury, Connecticut)
INVENTOR(S)	Javier E. Gonzalez (East Amherst, New York); Arthur F. Grant (Amherst, New York)
ABSTRACT	An improved method of sealing a ceramic part to a solid part made of ceramic, metal, cermet or a ceramic coated metal is provided. The improved method includes placing a bond agent comprising an Al₂O₃and SiO₂based glass-ceramic material and organic binder material on adjoining surfaces of the ceramic part and the solid part. The assembly is heated to a first target temperature that removes or dissolves the organic binder material from the bond agent and the assembly is subjected to a second induction heating step at a temperature ramp rate of between about 100° C. and 200° C. per minute to temperatures where the glass-ceramic material flows and wets the interface between adjoining surfaces. The assembly is rapidly cooled at a cooling rate of about 140° C. per minute or more to induce nucleation and re-crystallization of the glass-ceramic material to form a dense, durable and gas-tight seal.
FILED	Thursday, December 19, 2013
APPL NO	14/134276
ART UNIT	1746 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Separation B01D 65/003 (20130101) B01D 71/024 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 8/24 (20130101) Original (OR) Class C03C 10/0018 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/632 (20130101) C04B 35/638 (20130101) C04B 35/6264 (20130101) C04B 35/6342 (20130101) C04B 37/005 (20130101) C04B 37/025 (20130101) C04B 2235/6562 (20130101) C04B 2235/6565 (20130101) C04B 2237/10 (20130101) C04B 2237/40 (20130101) C04B 2237/60 (20130101) C04B 2237/348 (20130101) C04B 2237/401 (20130101) C04B 2237/708 (20130101) C04B 2237/765 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0282 (20130101) H01M 8/0286 (20130101) Technical Subjects Covered by Former US Classification Y10T 403/477 (20150115)
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09969823 — Synthesis and polymerization of vinyl triazolium ionic liquids

US 09969823	Luebke et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	United States Department of Energy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as represented by the Department of Energy (Washington, District of Columbia)
INVENTOR(S)	David Luebke (Bethel Park, Pennsylvania); Hunaid Nulwala (Pittsburgh, Pennsylvania); Krzysztof Matyjaszewski (Pittsburgh, Pennsylvania); Brian Adzima (San Francisco, California)
ABSTRACT	Herein, we describe polymerized ionic liquids, demonstrate the synthesis of polymerized ionic liquids, and demonstrate the polymerization of triazolium monomers. One embodiment shows the polymeriazation of the triazolium monomers with bis(trifluoromethanesulfonyl)imide anions. In another embodiment we show the feasibility of copolymerizing with commodity monomers such as styrene using free radical polymerization techniques.
FILED	Tuesday, November 24, 2015
APPL NO	14/951210
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 249/04 (20130101) C07D 249/06 (20130101) C07D 401/04 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 26/06 (20130101) Original (OR) Class
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09969970 — DNA-cell conjugates

US 09969970	Hsiao et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Basic Energy Sciences (BES) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Shih-Chia Hsiao (Oakland, California); Matthew B. Francis (Berkeley, California); Carolyn Bertozzi (Berkeley, California); Richard Mathies (Walnut Creek, California); Ravi Chandra (Newton, Massachusetts); Erik Douglas (Oakland, California); Amy Twite (Berkeley, California); Nicholas Toriello (San Carlos, California); Hiroaki Onoe (Tokyo, Japan)
ABSTRACT	The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
FILED	Tuesday, March 01, 2016
APPL NO	15/057604
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/6901 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

09969993 — Filamentous fungal host cells and methods of recombinantly producing proteins

US 09969993	Merino et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Sandra Merino (West Sacramento, California); Keith McFarland (Davis, California); Joel Cherry (Davis, California); Sarah Teter (Menlo Park, California)
ASSIGNEE(S)	Novozymes, Inc. (Davis, None)
INVENTOR(S)	Sandra Merino (West Sacramento, California); Keith McFarland (Davis, California); Joel Cherry (Davis, California); Sarah Teter (Menlo Park, California)
ABSTRACT	The present invention relates to cellulolytic compositions for degrading or converting cellulose-containing material and methods of producing and using the compositions.
FILED	Friday, May 30, 2008
APPL NO	12/130838
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/37 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2437 (20130101) Original (OR) Class C12N 9/2445 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) C12P 19/14 (20130101) C12P 19/16 (20130101) Enzymes C12Y 302/01004 (20130101) C12Y 302/01021 (20130101) C12Y 302/01091 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/16 (20130101) Y02E 50/17 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

09969994 — Hybrid polypeptides having cellobiohydrolase activity and polynucleotides encoding same

US 09969994	Liu et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	NOVOZYMES, INC. (David, California)
ASSIGNEE(S)	NOVOZYMES, INC. (Davis, California)
INVENTOR(S)	Ye Liu (Beijing, China PRC); Tarana Shaghasi (Dixon, California)
ABSTRACT	The present invention relates to hybrid polypeptides having cellobiohydrolase activity. The present invention also relates to polynucleotides encoding the hybrid polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and processes of using the hybrid polypeptides.
FILED	Thursday, October 06, 2016
APPL NO	15/287332
ART UNIT	1663 — Plants
CURRENT CPC	Peptides C07K 14/38 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) C12N 9/2437 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) C12P 19/02 (20130101) C12P 19/14 (20130101) C12P 2203/00 (20130101) Enzymes C12Y 302/01091 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/16 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/52 (20151101)
VIEW PATENT	@ USPTO: Full Text PDF

09970000 — Cell-based composite materials with programmed structures and functions

US 09970000	Kaehr et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Bryan J. Kaehr (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Jason L. Townson (Seattle, Washington)
ABSTRACT	The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.
FILED	Thursday, January 14, 2016
APPL NO	14/996048
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/14 (20130101) Original (OR) Class
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09970015 — Aspergillus fumigatus cellulolytic enzyme compositions and uses thereof

US 09970015	Shasky et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Novozymes, Inc. (Davis, California)
ASSIGNEE(S)	Novozymes, Inc. (Davis, California)
INVENTOR(S)	Jeffrey Shasky (Davis, California); Brett McBrayer (Sacramento, California)
ABSTRACT	The present invention relates to recombinant Trichoderma host cells producing Aspergillus fumigatus cellulolytic enzyme compositions and methods of producing and using the compositions.
FILED	Monday, April 17, 2017
APPL NO	15/489035
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 9/2437 (20130101) C12N 9/2471 (20130101) C12N 15/52 (20130101) Original (OR) Class C12N 15/80 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 9/00 (20130101) C12P 2203/00 (20130101)
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09970125 — Method for achieving sustained anisotropic crystal growth on the surface of a silicon melt

US 09970125	Mackintosh et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Brian H. Mackintosh (Concord, Massachusetts); Peter L. Kellerman (Essex, Massachusetts); Dawei Sun (Nashua, New Hampshire)
ASSIGNEE(S)	Varian Semiconductor Equipment Associates, Inc. (Gloucester, Massachusetts)
INVENTOR(S)	Brian H. Mackintosh (Concord, Massachusetts); Peter L. Kellerman (Essex, Massachusetts); Dawei Sun (Nashua, New Hampshire)
ABSTRACT	An apparatus for growing a crystalline sheet from a melt includes a cold block assembly. The cold block assembly may include a cold block and a shield surrounding the cold block and being at an elevated temperature with respect to that of the cold block, the shield defining an opening disposed along a surface of the cold block proximate a melt surface that defines a cold area comprising a width along a first direction of the cold block, the cold area operable to provide localized cooling of a region of the melt surface proximate the cold block. The apparatus may further include a crystal puller arranged to draw a crystalline seed in a direction perpendicular to the first direction when the cold block assembly is disposed proximate the melt surface.
FILED	Friday, February 17, 2012
APPL NO	13/398884
ART UNIT	1714 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 15/06 (20130101) C30B 15/14 (20130101) Original (OR) Class C30B 29/06 (20130101) Technical Subjects Covered by Former US Classification Y10T 117/1008 (20150115) Y10T 117/1044 (20150115) Y10T 117/1048 (20150115) Y10T 117/1068 (20150115)
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09970302 — Hot gas path component trailing edge having near wall cooling features

US 09970302	Lacy et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Benjamin Paul Lacy (Greer, South Carolina); Srikanth Chandrudu Kottilingam (Simpsonville, South Carolina); Carlos Miguel Miranda (Greer, South Carolina); Gary Michael Itzel (Simpsonville, South Carolina)
ABSTRACT	A hot gas path component includes a substrate having an outer surface and an inner surface. The inner surface defines an interior space. The outer surface defines a pressure side surface and a suction side surface. The pressure and suction side surfaces are joined together at a leading edge and at a trailing edge. A first cooling passage is formed in the suction side surface of the substrate. It is coupled in flow communication to the interior space. A second cooling passage, separate from the first cooling passage, is formed in the pressure side surface. The second cooling passage is coupled in flow communication to the interior space. A cover is disposed over at least a portion of the first and second cooling passages. The interior space channels a cooling fluid to the first and second cooling passages, which channel the cooling fluid therethrough to remove heat from the component.
FILED	Monday, June 15, 2015
APPL NO	14/739944
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/147 (20130101) F01D 5/186 (20130101) F01D 5/187 (20130101) Original (OR) Class F01D 5/288 (20130101) F01D 9/041 (20130101) F01D 25/12 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/122 (20130101) F05D 2240/304 (20130101) F05D 2240/305 (20130101) F05D 2240/306 (20130101) F05D 2260/202 (20130101) F05D 2260/204 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101) Y02T 50/676 (20130101)
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09970756 — High-sensitivity gas-mapping 3D imager and method of operation

US 09970756	Kreitinger et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Bridger Photonics, Inc. (Bozeman, Montana)
ASSIGNEE(S)	Bridger Photonics, Inc. (Bozeman, Montana)
INVENTOR(S)	Aaron Kreitinger (Bozeman, Montana); Michael Thorpe (Bozeman, Montana)
ABSTRACT	Measurement apparatuses and methods are disclosed for generating high-precision and -accuracy gas concentration maps that can be overlaid with 3D topographic images by rapidly scanning one or several modulated laser beams with a spatially-encoded transmitter over a scene to build-up imagery. Independent measurements of the topographic target distance and path-integrated gas concentration are combined to yield a map of the path-averaged concentration between the sensor and each point in the image. This type of image is particularly useful for finding localized regions of elevated (or anomalous) gas concentration making it ideal for large-area leak detection and quantification applications including: oil and gas pipeline monitoring, chemical processing facility monitoring, and environmental monitoring.
FILED	Wednesday, October 05, 2016
APPL NO	15/285550
ART UNIT	2877 — Optics
CURRENT CPC	Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 21/20 (20130101) Original (OR) Class Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 15/00 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/28 (20130101) G01M 3/38 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/39 (20130101) G01N 21/53 (20130101) G01N 2021/1793 (20130101) G01N 2021/1795 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 5/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00201 (20130101)
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09970820 — Room-temperature quantum noise limited spectrometry and methods of the same

US 09970820	Stevens et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
INVENTOR(S)	Charles G. Stevens (Danville, California); Joseph W. Tringe (Walnut Creek, California); Christopher T. Cunningham (Livermore, California)
ABSTRACT	According to one embodiment, a heterodyne detection system for detecting light, includes: a first input aperture configured to receive first light from a scene input; a second input aperture configured to receive second light from a local oscillator input; a broadband local oscillator configured to provide the second light to the second input aperture; a dispersive element configured to disperse the first light and the second light; and a final condensing lens coupled to a detector. The final condensing lens is configured to concentrate incident light from a primary condensing lens onto the detector. The detector is configured to sense a frequency difference between the first light and the second light; and the final condensing lens comprises a plasmonic condensing lens. Methods for forming a plasmonic condensing lens to enable room temperature quantum noise limited spectrometry are also disclosed.
FILED	Thursday, June 09, 2016
APPL NO	15/178444
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) G01J 3/453 (20130101) Original (OR) Class G01J 3/4338 (20130101)
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09970969 — Systems, methods, and software for determining spatially variable distributions of the dielectric properties of a heterogeneous material

US 09970969	Farrington
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Transcend Engineering and Technology, LLC (Bethel, Vermont)
ASSIGNEE(S)	Transcend Engineering and Technology, LLC (Bethel, Vermont)
INVENTOR(S)	Stephen P. Farrington (Stockbridge, Vermont)
ABSTRACT	Systems, methods, and software for measuring the spatially variable relative dielectric permittivity of materials along a linear or otherwise configured sensor element, and more specifically the spatial variability of soil moisture in one dimension as inferred from the dielectric profile of the soil matrix surrounding a linear sensor element. Various methods provided herein combine advances in the processing of time domain reflectometry data with innovations in physical sensing apparatuses. These advancements enable high temporal (and thus spatial) resolution of electrical reflectance continuously along an insulated waveguide that is permanently emplaced in contact with adjacent soils. The spatially resolved reflectance is directly related to impedance changes along the waveguide that are dominated by electrical permittivity contrast due to variations in soil moisture. Various methods described herein are thus able to monitor soil moisture in profile with high spatial resolution.
FILED	Thursday, July 30, 2015
APPL NO	14/813929
ART UNIT	2867 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/048 (20130101) G01N 33/246 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 27/06 (20130101) Original (OR) Class
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09971576 — Software development environment and method of compiling integrated source code

US 09971576	Jones et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Nvidia Corporation (Santa Clara, California)
ASSIGNEE(S)	Nvidia Corporation (Santa Clara, California)
INVENTOR(S)	Stephen Jones (Santa Clara, California); Mark Hairgrove (Santa Clara, California); Jaydeep Marathe (Santa Clara, California); Vivek Kini (Santa Clara, California); Bastiaan Aarts (Santa Clara, California)
ABSTRACT	A software development environment (SDE) and a method of compiling integrated source code. One embodiment of the SDE includes: (1) a parser configured to partition an integrated source code into a host code partition and a device code partition, the host code partition including a reference to a device variable, (2) a translator configured to: (2a) embed device machine code, compiled based on the device code partition, into a modified host code, (2b) define a pointer in the modified host code configured to be initialized, upon execution of the integrated source code, to a memory address allocated to the device variable, and (2c) replace the reference with a dereference to the pointer, and (3) a host compiler configured to employ a host library to compile the modified host code.
FILED	Wednesday, November 20, 2013
APPL NO	14/085649
ART UNIT	2193 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 8/30 (20130101) G06F 8/41 (20130101) Original (OR) Class
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09971713 — Multi-petascale highly efficient parallel supercomputer

US 09971713	Asaad et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	GLOBALFOUNDRIES INC. (Grand Cayman, Cayman Islands)
ASSIGNEE(S)	GLOBALFOUNDRIES INC. (Grand Cayman, Cayman Islands)
INVENTOR(S)	Sameh Asaad (Yorktown Heights, New York); Ralph E. Bellofatto (Yorktown Heights, New York); Michael A. Blocksome (Rochester, Minnesota); Matthias A. Blumrich (Yorktown Heights, New York); Peter Boyle (Yorktown Heights, New York); Jose R. Brunheroto (Yorktown Heights, New York); Dong Chen (Yorktown Heights, New York); Chen-Yong Cher (Yorktown Heights, New York); George L. Chiu (Yorktown Heights, New York); Norman Christ (Yorktown Heights, New York); Paul W. Coteus (Yorktown Heights, New York); Kristan D. Davis (Rochester, Minnesota); Gabor J. Dozsa (Yorktown Heights, New York); Alexandre E. Eichenberger (Yorktown Heights, New York); Noel A. Eisley (Yorktown Heights, New York); Matthew R. Ellavsky (Rochester, Minnesota); Kahn C. Evans (Rochester, Minnesota); Bruce M. Fleischer (Yorktown Heights, New York); Thomas W. Fox (Yorktown Heights, New York); Alan Gara (Yorktown Heights, New York); Mark E. Giampapa (Yorktown Heights, New York); Thomas M. Gooding (Rochester, Minnesota); Michael K. Gschwind (Yorktown Heights, New York); John A. Gunnels (Yorktown Heights, New York); Shawn A. Hall (Yorktown Heights, New York); Rudolf A. Haring (Yorktown Heights, New York); Philip Heidelberger (Yorktown Heights, New York); Todd A. Inglett (Rochester, Minnesota); Brant L. Knudson (Rochester, Minnesota); Gerard V. Kopcsay (Yorktown Heights, New York); Sameer Kumar (Yorktown Heights, New York); Amith R. Mamidala (Yorktown Heights, New York); James A. Marcella (Rochester, Minnesota); Mark G. Megerian (Rochester, Minnesota); Douglas R. Miller (Rochester, Minnesota); Samuel J. Miller (Rochester, Minnesota); Adam J. Muff (Rochester, Minnesota); Michael B. Mundy (Rochester, Minnesota); John K. O'Brien (Yorktown Heights, New York); Kathryn M. O'Brien (Yorktown Heights, New York); Martin Ohmacht (Yorktown Heights, New York); Jeffrey J. Parker (Rochester, Minnesota); Ruth J. Poole (Rochester, Minnesota); Joseph D. Ratterman (Rochester, Minnesota); Valentina Salapura (Yorktown Heights, New York); David L. Satterfield (Tewksbury, Massachusetts); Robert M. Senger (Yorktown Heights, New York); Burkhard Steinmacher-Burow (Beoblingen, Germany); William M. Stockdell (Rochester, Minnesota); Craig B. Stunkel (Yorktown Heights, New York); Krishnan Sugavanam (Yorktown Heights, New York); Yutaka Sugawara (Yorktown Heights, New York); Todd E. Takken (Yorktown Heights, New York); Barry M. Trager (Yorktown Heights, New York); James L. Van Oosten (Rochester, Minnesota); Charles D. Wait (Rochester, Minnesota); Robert E. Walkup (Yorktown Heights, New York); Alfred T. Watson (Rochester, Minnesota); Robert W. Wisniewski (Yorktown Heights, New York); Peng Wu (Yorktown Heights, New York)
ABSTRACT	A Multi-Petascale Highly Efficient Parallel Supercomputer of 100 petaflop-scale includes node architectures based upon System-On-a-Chip technology, where each processing node comprises a single Application Specific Integrated Circuit (ASIC). The ASIC nodes are interconnected by a five dimensional torus network that optimally maximize the throughput of packet communications between nodes and minimize latency. The network implements collective network and a global asynchronous network that provides global barrier and notification functions. Integrated in the node design include a list-based prefetcher. The memory system implements transaction memory, thread level speculation, and multiversioning cache that improves soft error rate at the same time and supports DMA functionality allowing for parallel processing message-passing.
FILED	Thursday, April 30, 2015
APPL NO	14/701371
ART UNIT	2182 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 9/06 (20130101) G06F 9/3885 (20130101) G06F 9/30047 (20130101) G06F 12/0811 (20130101) G06F 12/0831 (20130101) G06F 12/0862 (20130101) G06F 12/0864 (20130101) G06F 12/1027 (20130101) G06F 13/287 (20130101) Original (OR) Class G06F 15/76 (20130101) G06F 15/8069 (20130101) G06F 15/17381 (20130101) G06F 15/17387 (20130101) G06F 2212/602 (20130101) G06F 2212/1016 (20130101) G06F 2212/6022 (20130101) G06F 2212/6024 (20130101) G06F 2212/6032 (20130401) Climate Change Mitigation Technologies in Information and Communication Technologies [ICT] i.e Information and Communication Technologies Aiming at the Reduction of Their Own Energy Use Y02D 10/13 (20180101) Y02D 10/14 (20180101)
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09972553 — Packaging system with cleaning channel and method of making the same

US 09972553	Fang
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	Sandia Corporation (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Lu Fang (Albuquerque, New Mexico)
ABSTRACT	A packaging structure and method for surface mount integrated circuits reduces electrochemical migration (ECM) problems by including one or more cleaning channels to effectively and efficiently remove flux residue that may otherwise remain lodged in gaps between the surface mount package and the printed circuit board. A cleaning channel may be formed along a bottom surface of the surface mount package (i.e., the surface facing the printed circuit board), or along a portion of a top surface of the printed circuit board. In either case, the inclusion of a cleaning channel enlarges the gap between the bottom surface of the surface mount package and the printed circuit board and creates a path for contaminants to be flushed out during a cleaning process.
FILED	Thursday, December 22, 2016
APPL NO	15/388210
ART UNIT	2891 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/50 (20130101) H01L 23/057 (20130101) Original (OR) Class H01L 23/315 (20130101) H01L 23/49805 (20130101) H01L 25/065 (20130101)
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09972565 — Lateral vias for connections to buried microconductors

US 09972565	Adams et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	David P. Adams (Albuquerque, New Mexico); Kira L. Fishgrab (Albuquerque, New Mexico); Karl Douglas Greth (Albuquerque, New Mexico); Michael David Henry (Albuquerque, New Mexico); Jeffrey Stevens (Albuquerque, New Mexico); V. Carter Hodges (Albuquerque, New Mexico); Randy J. Shul (Albuquerque, New Mexico); Ronald S. Goeke (Albuquerque, New Mexico); Robert K. Grubbs (Boise, Idaho)
ABSTRACT	The present invention relates to a lateral via to provide an electrical connection to a buried conductor. In one instance, the buried conductor is a through via that extends along a first dimension, and the lateral via extends along a second dimension that is generally orthogonal to the first dimension. In another instance, the second dimension is oblique to the first dimension. Components having such lateral vias, as well as methods for creating such lateral vias are described herein.
FILED	Tuesday, June 07, 2016
APPL NO	15/175312
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/486 (20130101) H01L 21/4803 (20130101) H01L 21/4853 (20130101) H01L 23/3178 (20130101) H01L 23/5384 (20130101) H01L 23/5386 (20130101) H01L 23/49811 (20130101) H01L 23/49827 (20130101) Original (OR) Class H01L 23/49838 (20130101) H01L 24/16 (20130101) H01L 24/25 (20130101) H01L 2224/165 (20130101) H01L 2224/16112 (20130101) H01L 2224/25105 (20130101)
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09972736 — Spreading devices into a 2-D module layout

US 09972736	Koplow et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Jeffrey P. Koplow (San Ramon, California); Vipin P. Gupta (Reno, Nevada); Gregory N. Nielson (Albuquerque, New Mexico); Murat Okandan (Edgewood, New Mexico); Jose Luis Cruz-Campa (Albuquerque, New Mexico); Jeffrey S. Nelson (Albuquerque, New Mexico)
ABSTRACT	An apparatus, method, and system, the apparatus including a receiving member dimensioned to receive an array of microelectronic devices; and a linkage member coupled to the receiving member, the linkage member configured to move the receiving member in at least two dimensions so as to modify a spacing between the electronic devices within the array of microelectronic devices received by the receiving member. The method including coupling an array of microelectronic devices to an expansion assembly; and expanding the expansion assembly so as to expand the array of microelectronic devices in at least two directions within a single plane. The system including a support member; an expansion assembly coupled to the support member, the expansion assembly having a plurality of receiving members configured to move in at least two dimensions within a single plane; and a plurality of microelectronic devices coupled to each of the plurality of receiving members.
FILED	Wednesday, March 12, 2014
APPL NO	14/205839
ART UNIT	1757 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 29/49133 (20150115) Y10T 29/53174 (20150115) Y10T 29/53261 (20150115)
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09972795 — Organic light-emitting diode materials

US 09972795	Aspuru-Guzik et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Presidents and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Alan Aspuru-Guzik (Cambridge, Massachusetts); Rafael Gomez-Bombarelli (Cambridge, Massachusetts); Jorge Aguilera-Iparraguirre (Roslindale, Massachusetts); Marc Baldo (Lexington, Massachusetts); Troy Van Voorhis (Cambridge, Massachusetts); Timothy D. Hirzel (Quincy, Massachusetts); Matthias Bahlke (Somerville, Massachusetts); David McMahon (Cambridge, Massachusetts); Tony Chang-Chi Wu (Cambridge, Massachusetts)
ABSTRACT	Described herein are molecules for use in organic light emitting diodes. Example molecules comprise at least one moiety A and at least one moiety D. Values and preferred values of the moieties A and D are described herein. The molecules comprise at least one atom selected from Si, Se, Ge, Sn, P, or As.
FILED	Wednesday, May 13, 2015
APPL NO	15/310241
ART UNIT	2823 — Semiconductors/Memory
CURRENT CPC	Heterocyclic Compounds C07D 209/86 (20130101) C07D 421/14 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0814 (20130101) C07F 7/0816 (20130101) C07F 9/65683 (20130101) C07F 9/657163 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1007 (20130101) C09K 2211/1014 (20130101) C09K 2211/1022 (20130101) C09K 2211/1044 (20130101) C09K 2211/1048 (20130101) C09K 2211/1055 (20130101) C09K 2211/1077 (20130101) C09K 2211/1081 (20130101) C09K 2211/1085 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/007 (20130101) H01L 51/0069 (20130101) H01L 51/0071 (20130101) H01L 51/0072 (20130101) H01L 51/0094 (20130101) Original (OR) Class H01L 51/5016 (20130101) H01L 2251/552 (20130101) H01L 2251/5376 (20130101)
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09972867 — Cosolvent electrolytes for electrochemical devices

US 09972867	Wessells et al.
FUNDED BY	Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Alveo Energy, Inc. (Palo Alto, California)
ASSIGNEE(S)	Natron Energy, Inc. (Santa Clara, California)
INVENTOR(S)	Colin Deane Wessells (Palo Alto, California); Ali Firouzi (Saratoga, California); Shahrokh Motallebi (Los Gatos, California); Sven Strohband (Menlo Park, California)
ABSTRACT	A system and method for stabilizing electrodes against dissolution and/or hydrolysis including use of cosolvents in liquid electrolyte batteries for three purposes: the extension of the calendar and cycle life time of electrodes that are partially soluble in liquid electrolytes, the purpose of limiting the rate of electrolysis of water into hydrogen and oxygen as a side reaction during battery operation, and for the purpose of cost reduction.
FILED	Sunday, March 06, 2016
APPL NO	15/062171
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/36 (20130101) H01M 4/58 (20130101) H01M 4/60 (20130101) H01M 4/485 (20130101) H01M 4/505 (20130101) H01M 4/9008 (20130101) H01M 8/188 (20130101) H01M 10/08 (20130101) H01M 10/36 (20130101) H01M 10/345 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2004/027 (20130101) H01M 2220/10 (20130101) H01M 2220/20 (20130101) H01M 2250/10 (20130101) H01M 2250/20 (20130101) H01M 2300/0002 (20130101) H01M 2300/004 (20130101) H01M 2300/0025 (20130101) H01M 2300/0028 (20130101) H01M 2300/0037 (20130101) H01M 2300/0091 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 90/14 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 90/32 (20130101)
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09972969 — Compact high current, high efficiency laser diode driver

US 09972969	Fulkerson et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Edward Fulkerson (Livermore, California); Rodney K. Lanning (Pleasanton, California); Steven Telford (Livermore, California)
ABSTRACT	A device includes a u-channel shaped member and a printed circuit board including a plurality of capacitors. Each of the plurality of capacitors has a mounting surface mounted to the printed circuit board and an opposing heat transfer surface thermally coupled to the u-channel shaped member. The device also includes an output cable coupled to the printed circuit board and a return cable coupled to the printed circuit board. The device further includes a control transistor disposed inside the u-channel shaped member and a current sensing resistor disposed inside the u-channel shaped member.
FILED	Thursday, February 27, 2014
APPL NO	14/766954
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 1/203 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/0427 (20130101) H01S 5/0428 (20130101) Original (OR) Class H01S 5/02423 (20130101) H01S 5/02438 (20130101) H01S 5/02469 (20130101) H01S 5/4018 (20130101) H01S 5/06832 (20130101)
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09973092 — Gas tube-switched high voltage DC power converter

US 09973092	She et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
INVENTOR(S)	Xu She (Niskayuna, New York); James William Bray (Niskayuna, New York); Timothy John Sommerer (Niskayuna, New York); Rahul Chokhawala (Niskayuna, New York)
ABSTRACT	A direct current (DC)-DC converter includes a transformer and a gas tube-switched inverter circuit. The transformer includes a primary winding and a secondary winding. The gas tube-switched inverter circuit includes first and second inverter load terminals and first and second inverter input terminals. The first and second inverter load terminals are coupled to the primary winding. The first and second inverter input terminals are couplable to a DC node. The gas tube-switched inverter circuit further includes a plurality of gas tube switches respectively coupled between the first and second inverter load terminals and the first and second inverter input terminals. The plurality of gas tube switches is configured to operate to generate an alternating current (AC) voltage at the primary winding.
FILED	Friday, April 22, 2016
APPL NO	15/136375
ART UNIT	2838 — Electrical Circuits and Systems
CURRENT CPC	Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/0061 (20130101) H02M 3/33 (20130101) Original (OR) Class H02M 3/33584 (20130101)
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09974155 — Variable-pulse-shape pulsed-power accelerator

US 09974155	Stoltzfus et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	Sandia Corporation (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Brian S. Stoltzfus (Albuquerque, New Mexico); Kevin Austin (Albuquerque, New Mexico); Brian Thomas Hutsel (Sandia Park, New Mexico); David Reisman (Albuquerque, New Mexico); Mark E. Savage (Albuquerque, New Mexico); William A. Stygar (Albuquerque, New Mexico)
ABSTRACT	A variable-pulse-shape pulsed-power accelerator is driven by a large number of independent LC drive circuits. Each LC circuit drives one or more coaxial transmission lines that deliver the circuit's output power to several water-insulated radial transmission lines that are connected in parallel at small radius by a water-insulated post-hole convolute. The accelerator can be impedance matched throughout. The coaxial transmission lines are sufficiently long to transit-time isolate the LC drive circuits from the water-insulated transmission lines, which allows each LC drive circuit to be operated without being affected by the other circuits. This enables the creation of any power pulse that can be mathematically described as a time-shifted linear combination of the pulses of the individual LC drive circuits. Therefore, the output power of the convolute can provide a variable pulse shape to a load that can be used for magnetically driven, quasi-isentropic compression experiments and other applications.
FILED	Monday, August 24, 2015
APPL NO	14/833993
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/02 (20130101) Original (OR) Class H05H 9/005 (20130101) H05H 2007/022 (20130101)
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09974213 — Provisioning cooling elements for chillerless data centers

US 09974213	Chainer et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Timothy J. Chainer (Putnam Valley, New York); Pritish R. Parida (Fishkill, New York)
ABSTRACT	Systems and methods for cooling include one or more computing structure, an inter-structure liquid cooling system that includes valves configured to selectively provide liquid coolant to the one or more computing structures; a heat rejection system that includes one or more heat rejection units configured to cool liquid coolant; and one or more liquid-to-liquid heat exchangers that include valves configured to selectively transfer heat from liquid coolant in the inter-structure liquid cooling system to liquid coolant in the heat rejection system. Each computing structure further includes one or more liquid-cooled servers; and an intra-structure liquid cooling system that has valves configured to selectively provide liquid coolant to the one or more liquid-cooled servers.
FILED	Tuesday, May 19, 2015
APPL NO	14/715944
ART UNIT	3744 — Electrical Circuits and Systems
CURRENT CPC	Electric Digital Data Processing G06F 1/206 (20130101) G06F 1/3287 (20130101) G06F 2200/201 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/2079 (20130101) H05K 7/20263 (20130101) H05K 7/20272 (20130101) H05K 7/20763 (20130101) H05K 7/20772 (20130101) H05K 7/20836 (20130101) Original (OR) Class Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 60/1275 (20130101) Y02B 60/1282 (20130101)
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National Science Foundation (NSF)

09968280 — Method for insertion of a medical device within a body during a medical imaging process

US 09968280	Whitcomb et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Louis L. Whitcomb (Baltimore, Maryland); Axel Krieger (Alexandria, Virginia); Robert C. Susil (Baltimore, Maryland); Gabor Fichtinger (Bethesda, Maryland); Ergin Atalar (Bilkent Ankara, Turkey); Iulian I. Iordachita (Lutherville, Maryland)
ABSTRACT	A method for tracking movement of a movable portion of an interventional device disposed within a natural or artificial body opening is provided. In particular, image data of fiducials is acquired and therefrom an initial position of an interventional device movable portion with respect to a given coordinate system is determined. Next, real time position data from the encoders is acquired as the movable portion is moved from the initial position, and a displaced position from the initial position is determined. From this acquired information, a position of the movable portion in the coordinate system is determined using both the initial position as determined from the image data and the real time displaced position as determined from the encoders.
FILED	Tuesday, July 23, 2013
APPL NO	13/948614
ART UNIT	3737 — SELECT * FROM codes_techcenter;
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/064 (20130101) Original (OR) Class A61B 6/12 (20130101) A61B 8/12 (20130101) A61B 10/0241 (20130101) A61B 34/20 (20160201) A61B 34/25 (20160201) A61B 34/30 (20160201) A61B 90/11 (20160201) A61B 90/50 (20160201) A61B 2017/00911 (20130101) A61B 2090/374 (20160201) A61B 2090/376 (20160201) A61B 2090/378 (20160201)
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09968587 — Heterocycle analogs of CAI-1 as agonists of quorum sensing in vibrio

US 09968587	Bassler et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
INVENTOR(S)	Bonnie L. Bassler (Princeton, New Jersey); Lark J. Perez (Ewing, New Jersey); Martin F. Semmelhack (Princeton, New Jersey)
ABSTRACT	A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae. Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.
FILED	Tuesday, August 19, 2014
APPL NO	14/912207
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/36 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/53 (20130101) A61K 31/401 (20130101) Original (OR) Class A61K 31/401 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 207/333 (20130101)
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09968698 — Charged singlet-oxygen sensitizers and oppositely-charged surfactants

US 09968698	Whitten et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S)	STC. UNM (Albuquerque, New Mexico)
INVENTOR(S)	David G. Whitten (Albuquerque, New Mexico); Eric H. Hill (Albuquerque, New Mexico); Harry C. Pappas (Albuquerque, New Mexico)
ABSTRACT	The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.
FILED	Wednesday, November 05, 2014
APPL NO	14/533612
ART UNIT	1799 — Organic Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/30 (20130101) A01N 25/30 (20130101) A01N 33/12 (20130101) A01N 33/12 (20130101) A01N 33/12 (20130101) A01N 41/02 (20130101) A01N 41/04 (20130101) A01N 41/04 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/18 (20130101) Original (OR) Class
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09968892 — Functionalization of nanofibrous microfiltration membranes for water purification

US 09968892	Chu et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Benjamin Chu (Setauket, New York); Benjamin S. Hsiao (Setauket, New York); HongYang Ma (East Setauket, New York)
ASSIGNEE(S)	NATIONAL SCIENCE FOUNDATION (Arlington, Virginia)
INVENTOR(S)	Benjamin Chu (Setauket, New York); Benjamin S. Hsiao (Setauket, New York); HongYang Ma (East Setauket, New York)
ABSTRACT	A high flux and low pressure drop microfiltration (MF) membrane and a method for making the MF membrane. The microfiltration membranes are formed by a method that includes: preparing a nanofibrous structure; and modifying the surface of the nanofibrous structure with a surface modifier. The nanofibrous structure includes an electrospun nanofibrous scaffold or a polysaccharide nanofiber infused nanoscaffold or mixtures thereof. The electrospun nanofibrous scaffold can include polyacrylonitrile (PAN) or polyethersulfone (PES))/polyethylene terephthalate (PET) or mixtures thereof. The surface modifier includes polyethylenimine (PEI) and polyvinyl amine (Lupamin) cross-linked by ethylene glycol diglycidyl ether (EGdGE)/glycidyltrimethylammonium chloride (GTMACl) or poly(1-(1-vinylimidazolium)ethyl-3-vinylimdazolium dibromide (VEVIMIBr).
FILED	Wednesday, January 04, 2012
APPL NO	14/362028
ART UNIT	1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 61/147 (20130101) B01D 67/0004 (20130101) B01D 67/0006 (20130101) B01D 69/02 (20130101) B01D 69/10 (20130101) B01D 69/12 (20130101) B01D 69/125 (20130101) B01D 71/42 (20130101) B01D 71/48 (20130101) B01D 71/60 (20130101) Original (OR) Class B01D 71/68 (20130101) B01D 2323/30 (20130101) B01D 2323/39 (20130101) B01D 2325/20 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 37/0025 (20130101) B29C 47/0014 (20130101) B29C 47/0076 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2033/20 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/14 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/18 (20130101) D01F 11/06 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/728 (20130101)
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09968898 — Amphiphilic nanosheets and methods of making the same

US 09968898	Cheng et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	The Texas A and M University System (College Station, Texas)
ASSIGNEE(S)	The Texas A and M University System (College Station, Texas)
INVENTOR(S)	Zhengdong Cheng (College Station, Texas); Andres F. Mejia (Houston, Texas); Agustin Diaz (College Station, Texas); Abraham Clearfield (College Station, Texas); Mahboobul S. Mannan (College Station, Texas); Ya-Wen Chang (Lubbock, Texas)
ABSTRACT	In some embodiments, the present invention provides amphiphilic nanosheets that comprise lamellar crystals with at least two regions: a first hydrophilic region and a second hydrophobic region. In some embodiments, the amphiphilic nanosheets of the present invention also comprise a plurality of functional groups that are appended to the lamellar crystals. In some embodiments the functional groups are hydrophobic functional groups that are appended to the second region of the lamellar crystals. In some embodiments, the lamellar crystals comprise α-zirconium phosphates. Additional embodiments of the present invention pertain to methods of making the aforementioned amphiphilic nanosheets. Such methods generally comprise appending one or more functional groups to a stack of lamellar crystals; and exfoliating the stack of lamellar crystals for form the amphiphilic nanosheets.
FILED	Monday, March 06, 2017
APPL NO	15/450535
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 17/0064 (20130101) Original (OR) Class B01F 17/0071 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/06 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 112/08 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/90 (20130101) Y10S 977/755 (20130101) Y10S 977/896 (20130101) Y10S 977/902 (20130101)
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09969134 — Nanopatterned biopolymer optical device and method of manufacturing the same

US 09969134	Kaplan et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	David Kaplan (Concord, Massachusetts); Fiorenzo Omenetto (Wakefield, Massachusetts); Brian Lawrence (New York, New York); Mark Cronin-Golomb (Reading, Massachusetts)
ASSIGNEE(S)	Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S)	David Kaplan (Concord, Massachusetts); Fiorenzo Omenetto (Wakefield, Massachusetts); Brian Lawrence (New York, New York); Mark Cronin-Golomb (Reading, Massachusetts)
ABSTRACT	A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film on the substrate, where the solidified biopolymer film is formed with a surface having a nanopattern thereon. In another embodiment, the method also includes annealing the solidified biopolymer film. A nanopatterned biopolymer optical device includes a solidified biopolymer film with a surface having a nanopattern is also provided.
FILED	Monday, November 05, 2007
APPL NO	12/513394
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 1/00 (20130101) C08L 3/00 (20130101) C08L 5/00 (20130101) C08L 89/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) G02B 1/04 (20130101) G02B 1/04 (20130101) G02B 1/04 (20130101) G02B 1/04 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24479 (20150115)
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09969492 — Crop height estimation with unmanned aerial vehicles

US 09969492	Detweiler et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	NUtech Ventures (Lincoln, Nebraska)
ASSIGNEE(S)	NUTECH VENTURES (Lincoln, Nebraska)
INVENTOR(S)	Carrick Detweiler (Lincoln, Nebraska); David Anthony (Lincoln, Nebraska); Sebastian Elbaum (Lincoln, Nebraska)
ABSTRACT	An unmanned aerial vehicle (UAV) can be configured for crop height estimation. In some examples, the UAV includes an aerial propulsion system, a laser scanner configured to face downwards while the UAV is in flight, and a control system. The laser scanner is configured to scan through a two-dimensional scan angle and is characterized by a maximum range. The control system causes the UAV to fly over an agricultural field and maintain, using the aerial propulsion system and the laser scanner, a distance between the UAV and a top of crops in the agricultural field to within a programmed range of distances based on the maximum range of the laser scanner. The control system determines, using range data from the laser scanner, a crop height from the top of the crops to the ground.
FILED	Tuesday, September 06, 2016
APPL NO	15/257441
ART UNIT	3663 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) Original (OR) Class B64C 2201/12 (20130101) B64C 2201/027 (20130101) B64C 2201/123 (20130101) B64C 2201/145 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4808 (20130101) G01S 17/42 (20130101) G01S 17/88 (20130101) G01S 17/89 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0646 (20130101)
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09969620 — Nanoscale diamond particles and method of forming nanoscale diamond particles

US 09969620	Sankaran et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) Division of Chemical and Transport Systems (CTS)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	R. Mohan Sankaran (University Heights, Ohio); John C. Angus (Cleveland Heights, Ohio)
ABSTRACT	A method of forming nanoscale diamond particles comprises providing C₂and CH radicals at a low pressure, and nucleating the C₂and CH radicals to form carbon nanoparticles comprising a diamond phase and a non-diamond phase. The method further comprises removing at least a portion of the non-diamond phase in flight during the nucleation of the C₂and CH radicals to form a carbon powder comprising a plurality of nanoscale diamond particles.
FILED	Tuesday, March 31, 2015
APPL NO	14/674955
ART UNIT	1756 — Semiconductors/Memory
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/088 (20130101) B01J 2219/0875 (20130101) B01J 2219/0883 (20130101) B01J 2219/0898 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/25 (20170801) Original (OR) Class C01B 32/26 (20170801) C01B 32/28 (20170801)
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09969684 — N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

US 09969684	Toscano et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Cardioxyl Pharmaceuticals, Inc. (Chapel Hill, North Carolina); The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	Cardioxyl Pharmaceuticals, Inc. (Chapel Hill, North Carolina); The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	John P. Toscano (Glen Arm, Maryland); Frederick Arthur Brookfield (Abingdon, United Kingdom); Andrew D. Cohen (Mamaroneck, New York); Stephen Martin Courtney (Abingdon, United Kingdom); Lisa Marie Frost (Abingdon, United Kingdom); Vincent Jacob Kalish (Annapolis, Maryland)
ABSTRACT	The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
FILED	Friday, June 30, 2017
APPL NO	15/640342
ART UNIT	1671 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 311/48 (20130101) Original (OR) Class C07C 317/14 (20130101) C07C 323/67 (20130101) Heterocyclic Compounds C07D 213/74 (20130101) C07D 231/18 (20130101) C07D 261/10 (20130101) C07D 263/58 (20130101) C07D 285/125 (20130101) C07D 295/096 (20130101) C07D 307/82 (20130101) C07D 309/12 (20130101) C07D 317/14 (20130101) C07D 333/34 (20130101) C07D 333/62 (20130101)
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09969759 — Duplex-selective organometallic DNA intercalators

US 09969759	Mirkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE) Division of Materials Research (DMR)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); Chad M. Shade (Chicago, Illinois); Robert D. Kennedy (Midland, Michigan); Jessica Lynn Rouge (Evanston, Illinois); Soyoung E. Seo (Evanston, Illinois); Mary X. Wang (Evanston, Illinois)
ABSTRACT	Disclosed herein are organometallic complexes and methods of using the same in detecting double stranded DNA or RNA, selectively over single stranded DNA or RNA.
FILED	Friday, May 22, 2015
APPL NO	15/312221
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0053 (20130101) Original (OR) Class Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 23/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6816 (20130101) C12Q 2563/173 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44726 (20130101) G01N 27/44747 (20130101) G01N 33/582 (20130101) G01N 33/587 (20130101) G01N 33/5308 (20130101)
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09969773 — Polymers, pharmaceutical compositions and methods of synthesizing the same

US 09969773	Kirshenbaum et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Integrative Organismal Systems (IOS) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Kent Kirshenbaum (New York, New York); Paul Levine (Somerville, Massachusetts); Timothy Craven (Randolph, New Jersey)
ASSIGNEE(S)	NEW YORK UNIVERSITY (New York, New York)
INVENTOR(S)	Kent Kirshenbaum (New York, New York); Paul Levine (Somerville, Massachusetts); Timothy Craven (Randolph, New Jersey)
ABSTRACT	Novel methods to prepare novel polymers are disclosed. Oxazolidinyl compounds according to formula IV: are also disclosed as intermediate compounds that can be reacted with an acid to form a polymer of formula I.
FILED	Thursday, April 16, 2015
APPL NO	14/688026
ART UNIT	1671 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 5/0823 (20130101) C07K 5/1024 (20130101) C07K 5/06165 (20130101) C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) C07K 14/001 (20130101) C07K 17/08 (20130101)
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09969963 — Methods and apparatus for cell culture array

US 09969963	Hung et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Paul J. Hung (Berkeley, California); Philip J. Lee (Alameda, California); Luke P. Lee (Orinda, California)
ABSTRACT	Methods and systems are described for improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
FILED	Wednesday, September 16, 2015
APPL NO	14/855584
ART UNIT	1799 — Miscellaneous Articles, Stock Material
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 3/502761 (20130101) B01L 2200/027 (20130101) B01L 2200/0647 (20130101) B01L 2200/0689 (20130101) B01L 2300/0627 (20130101) B01L 2300/0816 (20130101) B01L 2400/086 (20130101) B01L 2400/088 (20130101) B01L 2400/0487 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/34 (20130101) C12M 29/06 (20130101) C12M 29/10 (20130101) C12M 41/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101)
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09970034 — Use of marine algae for co-producing alkenones, alkenone derivatives, and co-products

US 09970034	Reddy et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE) U.S. State Government Commonwealth of Massachusetts Massachusetts Clean Energy Center (MassCEC)
APPLICANT(S)	Woods Hole Oceanographic Institution (Woods Hole, Massachusetts); Western Washington University (Bellingham, Washington); Marine Biological Laboratory (Woods Hole, Massachusetts)
ASSIGNEE(S)	Woods Hole Oceanographic Institution (Woods Hole, Massachusetts); Western Washington University (Bellingham, Washington); Marine Biological Laboratory (Woods Hole, Massachusetts)
INVENTOR(S)	Christopher M. Reddy (Woods Hole, Massachusetts); Gregory W. O'Neil (Bellingham, Massachusetts); Scott R. Lindell (Woods Hole, Massachusetts)
ABSTRACT	A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis.
FILED	Saturday, January 17, 2015
APPL NO	14/599460
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Heterocyclic Compounds C07D 303/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) C12P 7/649 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/13 (20130101)
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09970117 — Heterocycle catalyzed electrochemical process

US 09970117	Cole et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Liquid Light, Inc. (Monmouth Junction, New Jersey)
ASSIGNEE(S)	Princeton University (Princeton, New Jersey); Avantium Knowledge Centre B.V. (Amsterdam, Netherlands)
INVENTOR(S)	Emily Barton Cole (Houston, Texas); Andrew B. Bocarsly (Plainsboro, New Jersey)
ABSTRACT	A method for heterocycle catalyzed electrochemical reduction of a carbonyl compound is disclosed. The method generally includes steps (A) to (C). Step (A) may introduce the carbonyl compound into a solution of an electrolyte and a heterocycle catalyst in a divided electrochemical cell. The divided electrochemical cell may include an anode in a first cell compartment and a cathode in a second cell compartment. The cathode generally reduces the carbonyl compound to at least one aldehyde compound. Step (B) may vary which of the aldehyde compounds is produced by adjusting one or more of (i) a cathode material, (ii) the electrolyte, (iii) the heterocycle catalyst, (iv) a pH level and (v) an electrical potential. Step (C) may separate the aldehyde compounds from the solution.
FILED	Wednesday, September 17, 2014
APPL NO	14/488848
ART UNIT	1759 — Miscellaneous Articles, Stock Material
CURRENT CPC	Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/003 (20130101) C25B 3/04 (20130101) Original (OR) Class C25B 3/105 (20130101)
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09970932 — Non-covalent patterned chemical features and use thereof in MALDI-based quality control

US 09970932	Woodbury et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S)	Neal Woodbury (Tempe, Arizona); Stephen Johnston (Tempe, Arizona); Zhan Gong Zhao (Tuscon, Arizona); Matthew Greving (Phoenix, Arizona)
ABSTRACT	The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
FILED	Friday, March 14, 2014
APPL NO	14/773751
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54366 (20130101) Original (OR) Class
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09971228 — Direct entangled triplet-photon sources and methods for their design and fabrication

US 09971228	Mazur et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	President And Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President And Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Eric Mazur (Concord, Massachusetts); Christopher Courtney Evans (Ithica, New York); Michael Gerhard Moebius (Somerville, Massachusetts); Orad Reshef (Cambridge, Massachusetts); Sarah E. Griesse-Nascimento (Cambridge, Massachusetts)
ABSTRACT	In one aspect, a device for generating triplet photons is disclosed, which includes a waveguide extending from a proximal end for receiving pump radiation to a distal end through which triplet photons generated via nonlinear interaction of the pump radiation with the waveguide exit the waveguide, where the waveguide is configured such that the triplet photons generated within the waveguide reach its distal end at a rate in a range of about 0.05 triplet photons/second/mW and 0.3 triplet photons/second/mW, e.g., in a range of about 0.1 triplet photons/second/mW to about 0.2 triplet photons/second/mW.
FILED	Friday, April 15, 2016
APPL NO	15/130482
ART UNIT	2883 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/39 (20130101) G02F 1/353 (20130101) Original (OR) Class G02F 1/355 (20130101) G02F 1/365 (20130101) G02F 1/395 (20130101) G02F 1/3501 (20130101) G02F 1/3526 (20130101) G02F 1/3544 (20130101) G02F 2001/354 (20130101) G02F 2001/3542 (20130101) G02F 2202/36 (20130101) Transmission H04B 10/70 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

09971891 — Methods, systems, and media for detecting covert malware

US 09971891	Bowen et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Multidisciplinary University Research Initiative (MURI) National Science Foundation (NSF)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of the New York (New York, New York)
INVENTOR(S)	Brian M. Bowen (New York, New York); Pratap V. Prabhu (New York, New York); Vasileios P. Kemerlis (New York, New York); Stylianos Sidiroglou (Astoria, New York); Salvatore J. Stolfo (Ridgewood, New Jersey); Angelos D. Keromytis (New York, New York)
ABSTRACT	Methods, systems, and media for detecting covert malware are provided. In accordance with some embodiments, a method for detecting covert malware in a computing environment is provided, the method comprising: receiving a first set of user actions; generating a second set of user actions based on the first set of user actions and a model of user activity; conveying the second set of user actions to an application inside the computing environment; determining whether state information of the application matches an expected state after the second set of user actions is conveyed to the application; and determining whether covert malware is present in the computing environment based at least in part on the determination.
FILED	Tuesday, August 13, 2013
APPL NO	13/965619
ART UNIT	2494 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/56 (20130101) Original (OR) Class G06F 21/566 (20130101) G06F 21/577 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1441 (20130101) H04L 63/1491 (20130101)
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09972698 — Fabricating large area multi-tier nanostructures

US 09972698	Sreenivasan et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Sidlgata V. Sreenivasan (Austin, Texas); Praveen Joseph (Austin, Texas); Ovadia Abed (Austin, Texas); Michelle Grigas (Austin, Texas); Akhila Mallavarapu (Austin, Texas); Paras Ajay (Austin, Texas)
ABSTRACT	Methods for fabricating and replicating self-aligned multi-tier nanoscale structures for a variety of cross-sectional geometries. These methods can utilize a single lithography step whereby the need for alignment and overlay in the process is completely eliminated thereby enabling near-zero overlay error. Furthermore, techniques are developed to use these methods to fabricate self-aligned nanoscale multi-level/multi-height patterns with various shapes for master templates, replica templates and nanoimprint based pattern replication. Furthermore, the templates can be used to pattern multiple levels in a sacrificial polymer resist and achieve pattern transfer of the levels into a variety of substrates to form completed large area nanoelectronic and nanophotonic devices using only one patterning step.
FILED	Monday, February 26, 2018
APPL NO	15/904757
ART UNIT	2894 — Semiconductors/Memory
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/124 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0228 (20130101) H01L 21/0271 (20130101) H01L 21/0337 (20130101) H01L 21/02164 (20130101) H01L 21/2855 (20130101) H01L 21/3081 (20130101) H01L 21/3086 (20130101) H01L 21/30604 (20130101) H01L 21/31144 (20130101) H01L 21/76224 (20130101) H01L 28/90 (20130101) H01L 29/665 (20130101) H01L 29/6653 (20130101) H01L 29/6659 (20130101) Original (OR) Class H01L 29/66515 (20130101) H01L 29/66545 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

09972699 — Fabricating large area multi-tier nanostructures

US 09972699	Sreenivasan et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Sidlgata V. Sreenivasan (Austin, Texas); Praveen Joseph (Austin, Texas); Ovadia Abed (Austin, Texas); Michelle Grigas (Austin, Texas); Akhila Mallavarapu (Austin, Texas); Paras Ajay (Austin, Texas)
ABSTRACT	Methods for fabricating and replicating self-aligned multi-tier nanoscale structures for a variety of cross-sectional geometries. These methods can utilize a single lithography step whereby the need for alignment and overlay in the process is completely eliminated thereby enabling near-zero overlay error. Furthermore, techniques are developed to use these methods to fabricate self-aligned nanoscale multi-level/multi-height patterns with various shapes for master templates, replica templates and nanoimprint based pattern replication. Furthermore, the templates can be used to pattern multiple levels in a sacrificial polymer resist and achieve pattern transfer of the levels into a variety of substrates to form completed large area nanoelectronic and nanophotonic devices using only one patterning step.
FILED	Monday, February 26, 2018
APPL NO	15/905024
ART UNIT	2894 — Semiconductors/Memory
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/124 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0228 (20130101) H01L 21/0271 (20130101) H01L 21/0337 (20130101) H01L 21/02164 (20130101) H01L 21/2855 (20130101) H01L 21/3081 (20130101) H01L 21/3086 (20130101) H01L 21/30604 (20130101) H01L 21/31144 (20130101) H01L 21/76224 (20130101) H01L 28/90 (20130101) H01L 29/665 (20130101) H01L 29/6653 (20130101) H01L 29/6659 (20130101) Original (OR) Class H01L 29/66515 (20130101) H01L 29/66545 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

09972799 — Gate-tunable p-n heterojunction diode, and fabrication method and application of same

US 09972799	Hersam et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Mark C. Hersam (Wilmette, Illinois); Deep M. Jariwala (Evanston, Illinois); Vinod K. Sangwan (Evanston, Illinois)
ABSTRACT	A method of fabricating a diode includes forming a first semiconductor layer having a first portion and a second portion extending from the first portion on a substrate; forming first and second electrodes on the substrate, the first electrode extending over and being in contact with the first portion of the first semiconductor layer; forming an insulting film to cover the first electrode and the first portion of the first semiconductor layer; and forming a second semiconductor layer having a first portion and a second portion extending from the first portion on the substrate. The second portion of the second semiconductor layer overlapping with the second portion of the first semiconductor layer to define a vertically stacked heterojunction therewith. The first portion of the second semiconductor layer extending over and being in contact with the second electrode. Each of the first and second semiconductor layers includes an atomically thin semiconductor.
FILED	Wednesday, September 14, 2016
APPL NO	15/265166
ART UNIT	2894 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 51/0048 (20130101) H01L 51/102 (20130101) H01L 51/0587 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

09972962 — Tuning multi-input complex dynamic systems using sparse representations of performance and extremum-seeking control

US 09972962	Kutz et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Mathematical Sciences (DMS)
APPLICANT(S)	University of Washington (Seattle, Washington)
ASSIGNEE(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington)
INVENTOR(S)	Jose Nathan Kutz (Seattle, Washington); Steven Brunton (Seattle, Washington); Xing Fu (Seattle, Washington)
ABSTRACT	Systems and methods for tuning multi-input complex dynamic systems in order to automatically obtain optimal performance are provided. Training is performed by measuring performance of the complex system using an objective function for a sparse sampling of input values over a variety of dynamic regimes. A sparse representation of the performance for each dynamic regime is stored in a library. At run-time, performance is measured and matched to a sparse representation in the library, and the complex system is configured with the optimal input values associated with the matching sparse representation from the library. Performance may then be optimized using an extremum-seeking controller. In some embodiments, the disclosed techniques are applied to a self-tuning mode-locked laser. In some embodiments, the disclosed techniques are applied to other complex systems such as phased array antennas and neurostimulation systems.
FILED	Tuesday, August 11, 2015
APPL NO	14/823944
ART UNIT	2115 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0014 (20130101) H01S 3/139 (20130101) H01S 3/1115 (20130101) Original (OR) Class H01S 3/1305 (20130101) H01S 3/06791 (20130101) H01S 3/10069 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

09973086 — Low input voltage boost converter with peak inductor current control and offset compensated zero detection

US 09973086	Calhoun et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)	UNIVERSITY OF VIRGINA PATENT FOUNDATION (Charlottesville, Virginia)
INVENTOR(S)	Benton Calhoun (Charlottesville, Virginia); Aatmesh Shrivastava (Charlottesville, Virginia)
ABSTRACT	The low input voltage boost converter with peak inductor current control and offset compensated zero detection provide a boost converter scheme to harvest energy from sources with small output voltages. Some embodiments described herein includes a thermoelectric boost converter that combines an I_PEAKcontrol scheme with offset compensation and duty cycled comparators to enable energy harvesting from TEG inputs as low as 5 mV to 10 mV, and the peak inductor current is independent to first order of the input voltage and output voltage. A control circuit can be configured to sample the input voltage (V_IN) and then generate a pulse with a duration inversely proportional to V_INso as to control the boost converter switches such that a substantially constant peak inductor current is generated.
FILED	Monday, September 19, 2016
APPL NO	15/268783
ART UNIT	2838 — Electrical Circuits and Systems
CURRENT CPC	Systems for Regulating Electric or Magnetic Variables G05F 1/462 (20130101) G05F 1/565 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/088 (20130101) H02M 3/156 (20130101) H02M 3/158 (20130101) Original (OR) Class H02M 2001/0025 (20130101)
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09973275 — System and method for lighting and building occupant tracking

US 09973275	Nyarko et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Morgan State University (Baltimore, Maryland)
ASSIGNEE(S)	Morgan State University (Baltimore, Maryland)
INVENTOR(S)	Kofi Nyarko (Essex, Maryland); Christian Emiyah (Baltimore, Maryland); Samuel Mbugua (Baltimore, Maryland)
ABSTRACT	Disclosed is a system and method for using visible light communication (“VLC”) to perform indoor position location. Through use of a system and method configured as set forth herein, the position of any appropriately marked person or item may be found indoors using data interconnected modules that communicate with one another via RF and visible light. A mobile receiver in the form of a tag or badge attached to the person or item to be tracked receives a VLC signal from a plurality of lighting modules, and transmits back to a processor the data it received so that the processor is able determine the tag's or badge's physical position with respect to the individual network modules.
FILED	Monday, February 13, 2017
APPL NO	15/430904
ART UNIT	2637 — Optical Communications
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 1/70 (20130101) Transmission H04B 10/116 (20130101) Original (OR) Class Multiplex Communication H04J 14/086 (20130101) Wireless Communication Networks H04W 4/04 (20130101) H04W 64/00 (20130101)
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09973473 — Methods, systems, and computer readable media for rapid filtering of opaque data traffic

US 09973473	White et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The Regents of the University of Michigan (Ann Arbor, Michigan); SRI International (Menlo Park, California)
ASSIGNEE(S)	THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina)
INVENTOR(S)	Andrew Maxwell White (Chapel Hill, North Carolina); Fabian Monrose (Chapel Hill, North Carolina); Srinivas Krishnan (Berkeley, California); Phillip Andrew Porras (Cupertino, California); Michael Donald Bailey (Ypsilanti, Michigan)
ABSTRACT	Methods, systems, and computer readable media for rapid filtering of opaque data traffic are disclosed. According to one method, the method includes receiving a packet containing a payload. The method also includes analyzing a portion of the payload for determining whether the packet contains compressed or encrypted data. The method further includes performing, if the packet contains compressed or encrypted data, at least one of sending the packet to an opaque traffic analysis engine for analysis, discarding the packet, logging the packet, or marking the packet.
FILED	Wednesday, March 13, 2013
APPL NO	14/387967
ART UNIT	2495 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 63/0245 (20130101) Original (OR) Class H04L 63/1416 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

09973524 — Information technology security assessment system

US 09973524	Boyer et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	BitSight Technologies, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)	BitSight Technologies, Inc. (Cambridge, Massachusetts)
INVENTOR(S)	Stephen Boyer (Cambridge, Massachusetts); Nagarjuna Venna (Waltham, Massachusetts); Megumi Ando (Cambridge, Massachusetts)
ABSTRACT	A method and system for creating a composite security rating from security characterization data of a third party computer system. The security characterization data is derived from externally observable characteristics of the third party computer system. Advantageously, the composite security score has a relatively high likelihood of corresponding to an internal audit score despite use of externally observable security characteristics. Also, the method and system may include use of multiple security characterizations all solely derived from externally observable characteristics of the third party computer system.
FILED	Wednesday, November 18, 2015
APPL NO	14/944484
ART UNIT	2492 — Cryptography and Security
CURRENT CPC	Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0639 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 43/062 (20130101) H04L 43/0876 (20130101) H04L 61/2007 (20130101) H04L 63/1433 (20130101) Original (OR) Class H04L 67/20 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Aeronautics and Space Administration (NASA)

09970389 — Antivortex device and method of assembling thereof

US 09970389	Lopez et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Marshall Space Flight Center (MSFC)
APPLICANT(S)	The Boeing Company (Seal Beach, California)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Alfredo Lopez (Long Beach, California); Gary David Grayson (Huntington Beach, California); Stephen Michael Addison (Huntsville, Alabama)
ABSTRACT	An antivortex device for use in suppressing formation of a vortex created by fluid flowing through multiple outlet ports defined in a sump is provided. The antivortex device includes a plurality of center plates extending through a central axis of the sump, an extension plate substantially aligned with one of the plurality of center plates and extending substantially radially outward from the central axis, and a top plate coupled to the plurality of center plates.
FILED	Thursday, March 06, 2014
APPL NO	14/199093
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/402 (20130101) Jet-propulsion Plants F02K 9/60 (20130101) F02K 9/605 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/12 (20130101) F05D 2260/602 (20130101) F05D 2300/514 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49346 (20150115) Y10T 137/86348 (20150401)
VIEW PATENT	@ USPTO: Full Text PDF

09970781 — Apparatus for three-axis IMU calibration with a single-axis rate table

US 09970781	Christian et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	West Virginia University (Morgantown, West Virginia)
ASSIGNEE(S)	WEST VIRGINIA UNIVERSITY (Morgantown, West Virginia)
INVENTOR(S)	John A. Christian (Morgantown, West Virginia); Drew E. Bittner (Greencastle, Pennsylvania)
ABSTRACT	Various methods and apparatuses are provided for calibrating a three-axis IMU sensor package using a single-axis rate table. In one embodiment, a method includes adjusting an x-axis position of a sensor by rotating an inner assembly along the circumference of the inner surface of the circular frame, adjusting a y-axis position of the sensor by rotating a portion of the inner assembly, spinning the single-axis rate table to generate z-axis rotation of the apparatus which results in simultaneous stimulation of all three axes of the sensor assembly, and obtaining measurements from the sensor corresponding to the x-axis position, the y-axis position, and the z-axis rotation of the apparatus.
FILED	Tuesday, March 01, 2016
APPL NO	15/057658
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 25/00 (20130101) Original (OR) Class
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09970782 — RFID-enabled angular position sensing system

US 09970782	Fink et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America as represented by the Administrator of the National Aeronautics and Space (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Patrick W. Fink (Missouri City, Texas); Timothy F. Kennedy (Sugar Land, Texas); Gregory Y. Lin (Friendswood, Texas); Phong H. Ngo (Friendswood, Texas); Si Hui Yang (Houston, Texas)
ABSTRACT	An angular position sensing system includes a first support with ring-shaped elements disposed thereon and spaced apart from one another in a curvilinear arrangement. Each ring-shaped element includes an electrically-conductive ring and an RFID integrated circuit electrically coupled to its electrically-conductive ring. A second support has an antenna coupled thereto that defines an electrically-conductive path commensurate in size and shape to at least a portion of the electrically-conductive ring. An interrogator transmits a signal to the antenna wherein electric current is generated along the antenna's electrically-conductive path and electromagnetic energy emanates from the antenna. Any ring-shaped element and its RFID integrated circuit energized by the electromagnetic energy generates in response a data transmission for receipt by the interrogator. A processor coupled to the interrogator derives information related to an angular position of one of the first support and second support using the data transmission.
FILED	Thursday, March 24, 2016
APPL NO	15/080048
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/12 (20130101) Original (OR) Class
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09970914 — Gas sensors with contact pads

US 09970914	Xu et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Administrator of National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Jennifer Xu (Westlake, Ohio); Gary W. Hunter (Oberlin, Ohio)
ABSTRACT	Systems, methods, and other embodiments associated with gas detecting sensors. According to one embodiment, a gas sensor includes a metal layer, a barrier interlayer, a substrate layer, a first insulating layer, a conduction path, a contact pad, and a second insulating layer. The conduction path connects the metal layer to the contact pad. The second insulating layer prevents diffusion through the contact pad, the conduction path, or the metal layer. The sensor includes a wire bonded electrical connection to the contact pad such that voltage can be determined and/or applied.
FILED	Monday, April 06, 2015
APPL NO	14/679278
ART UNIT	2854 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/02 (20130101) G01N 27/129 (20130101) G01N 33/0036 (20130101) Original (OR) Class G01N 33/0047 (20130101) G01N 33/225 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0495 (20130101) H01L 29/47 (20130101) H01L 29/872 (20130101) H01L 29/1608 (20130101) H01L 29/6606 (20130101) H01L 29/66143 (20130101)
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Department of Agriculture (USDA)

09969108 — Method of forming a cellulose nanocrystalline film

US 09969108	Youngblood et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, India); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia)
ASSIGNEE(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia)
INVENTOR(S)	Jeffrey P. Youngblood (Crawfordsville, Indiana); Robert J. Moon (Marietta, Georgia); Alex Reising (Lafayette, Indiana)
ABSTRACT	A method is provided for forming a substantially uniaxially-oriented, high content cellulose nanocrystal film. The method includes providing a plant-biomass-based suspension of cellulose nanocrystals and altering the pH of the cellulose nanocrystals to a substantially neutral pH. The suspension is sheared at a shearing rate. The method further includes orienting the cellulose nanocrystals in a substantially axial direction and removing water from the sheared cellulose nanocrystal suspension. As a result, a substantially uniaxially-oriented cellulose nanocrystal film is formed.
FILED	Wednesday, February 17, 2016
APPL NO	15/045802
ART UNIT	1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 41/003 (20130101) Original (OR) Class B29C 41/24 (20130101) B29C 41/50 (20130101) B29C 55/00 (20130101) B29C 70/14 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2001/00 (20130101) B29K 2105/162 (20130101) B29K 2995/0077 (20130101) Polysaccharides; Derivatives Thereof C08B 15/08 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2301/02 (20130101) C08J 2301/12 (20130101) Compositions of Macromolecular Compounds C08L 1/02 (20130101)
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09969492 — Crop height estimation with unmanned aerial vehicles

US 09969492	Detweiler et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	NUtech Ventures (Lincoln, Nebraska)
ASSIGNEE(S)	NUTECH VENTURES (Lincoln, Nebraska)
INVENTOR(S)	Carrick Detweiler (Lincoln, Nebraska); David Anthony (Lincoln, Nebraska); Sebastian Elbaum (Lincoln, Nebraska)
ABSTRACT	An unmanned aerial vehicle (UAV) can be configured for crop height estimation. In some examples, the UAV includes an aerial propulsion system, a laser scanner configured to face downwards while the UAV is in flight, and a control system. The laser scanner is configured to scan through a two-dimensional scan angle and is characterized by a maximum range. The control system causes the UAV to fly over an agricultural field and maintain, using the aerial propulsion system and the laser scanner, a distance between the UAV and a top of crops in the agricultural field to within a programmed range of distances based on the maximum range of the laser scanner. The control system determines, using range data from the laser scanner, a crop height from the top of the crops to the ground.
FILED	Tuesday, September 06, 2016
APPL NO	15/257441
ART UNIT	3663 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) Original (OR) Class B64C 2201/12 (20130101) B64C 2201/027 (20130101) B64C 2201/123 (20130101) B64C 2201/145 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4808 (20130101) G01S 17/42 (20130101) G01S 17/88 (20130101) G01S 17/89 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0646 (20130101)
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PP029292 — Lantana camara plant named ‘UF-1013A-2A’

US PP29292	Deng
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Florida Foundation Seed Producers, Inc. (Marianna, Florida)
ASSIGNEE(S)	Florida Foundation Seed Producers, Inc. (Marianna, Florida)
INVENTOR(S)	Zhanao Deng (Riverview, Florida)
ABSTRACT	A new and distinct cultivar of Lantana camara plant named ‘UF-1013A-2A’, characterized by its moderate vigor, mounding growth habit, dense branches, round plant form and canopy, free flowering, bright yellow and red flowers, little fruiting, few seeds, high level of female infertility, low level of pollen stainability, high level of male infertility, and lack of hybridization with Lantana depressa.
FILED	Thursday, December 08, 2016
APPL NO	15/530167
ART UNIT	1661 — Plants
CURRENT CPC	Plants PLT/227
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Department of Commerce (DOC)

09968902 — Microfluidic devices and methods for gene synthesis

US 09968902	Chu
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	Gen9, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)	Gen9, Inc. (Cambridge, Massachusetts)
INVENTOR(S)	Larry Li-Yang Chu (Brighton, Massachusetts)
ABSTRACT	Certain aspects of the present invention provide devices and methods for preparing oligonucleotides and for assembling nucleic acid molecules using microfluidic devices.
FILED	Friday, November 20, 2015
APPL NO	14/946811
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class B01J 2219/0052 (20130101) B01J 2219/00286 (20130101) B01J 2219/00511 (20130101) B01J 2219/00529 (20130101) B01J 2219/00596 (20130101) B01J 2219/00619 (20130101) B01J 2219/00653 (20130101) B01J 2219/00655 (20130101) B01J 2219/00722 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) B01L 7/52 (20130101) B01L 2200/027 (20130101) B01L 2200/028 (20130101) B01L 2300/161 (20130101) B01L 2300/1861 (20130101) B01L 2400/0478 (20130101) B01L 2400/0487 (20130101)
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09970127 — Method and apparatus for producing large, single-crystals of aluminum nitride

US 09970127	Schowalter et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Research Laboratory (AFRL) Department of the Navy (DON) Office of Naval Research (ONR) Missile Defense Agency (MDA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Crystal IS, Inc. (Green Island, New York)
ASSIGNEE(S)	CRYSTAL IS, INC. (Green Island, New York)
INVENTOR(S)	Leo Schowalter (Latham, New York); Glen A. Slack (Scotia, New York); Juan Carlos Rojo (South Beach, New York); Robert T. Bondokov (Watervliet, New York); Kenneth E. Morgan (Castleton, New York); Joseph A. Smart (Mooresville, North Carolina)
ABSTRACT	Bulk single crystals of AlN having a diameter greater than about 25 mm and dislocation densities of about 10,000 cm⁻²or less and high-quality AlN substrates having surfaces of any desired crystallographic orientation fabricated from these bulk crystals.
FILED	Monday, August 08, 2016
APPL NO	15/231141
ART UNIT	1785 — Miscellaneous Articles, Stock Material
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 11/003 (20130101) C30B 23/00 (20130101) C30B 23/025 (20130101) C30B 25/10 (20130101) C30B 25/14 (20130101) C30B 25/16 (20130101) Original (OR) Class C30B 25/20 (20130101) C30B 29/403 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/02389 (20130101) H01L 21/02458 (20130101) H01L 21/02634 (20130101) H01L 29/04 (20130101) H01L 29/32 (20130101) H01L 29/205 (20130101) H01L 29/0657 (20130101) H01L 29/2003 (20130101) H01L 29/7787 (20130101) H01L 29/66462 (20130101) H01L 33/12 (20130101) H01L 33/025 (20130101) H01L 33/0075 (20130101) H01L 33/325 (20130101) H01L 2924/00 (20130101) H01L 2924/0002 (20130101) H01L 2924/0002 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/21 (20150115)
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09970859 — Sample holder, detector mask, and scope system

US 09970859	Holm et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Washington, District of Columbia)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Washington, District of Columbia)
INVENTOR(S)	Jason D. Holm (Louisville, Colorado); Robert R. Keller (Louisville, Colorado); Katherine P. Rice (Fitchburg, Wisconsin)
ABSTRACT	A detector mask transmits selectively a plurality of probe particles to a particle detector, the detector mask includes: a plate including a plate wall disposed in the plate and enclosing a transmission orifice arranged in a transmission profile to: transmit probe particles having a trajectory coincident with the transmission orifice, block probe particles having a trajectory external to the transmission orifice, and form a probe particle beam comprising the probe particles transmitted by the transmission orifice to the particle detector, wherein the transmission profile includes a sector, a semi-circle, an annular sector, or a combination including at least one of the foregoing first transmission profiles.
FILED	Wednesday, January 11, 2017
APPL NO	15/403943
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/04 (20130101) G01N 21/03 (20130101) Original (OR) Class G01N 23/00 (20130101) Optical Elements, Systems, or Apparatus G02B 21/361 (20130101)
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Small Business Administration (SBA)

09968726 — Methods for implanting subcutaneous vascular access ports

US 09968726	Phillips et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	DF Vital Holdings, LLC (Wilmington, Delaware)
ASSIGNEE(S)	DF Vital Holdings, LLC (Wilmington, Delaware)
INVENTOR(S)	Christopher M. Phillips (Salt Lake City, Utah); Nathaniel P. Young (Salt Lake City, Utah); Trent J. Perry (Kaysville, Utah); Duane D. Blatter (Salt Lake City, Utah); Mark A. Crawford (Sandy, Utah); G. Doug Smith (Sandy, Utah); Steven Johnson (Lehi, Utah)
ABSTRACT	A method of securing an access port to a vessel can include positioning an access port adjacent to a wall of the vessel. The access port can include an implantation passageway and a guidance passageway that is connected to the implantation passageway. The implantation passageway can be open, during the positioning of the access port, at a position proximal to a location at which the implantation passageway and the guidance passageway are connected. The method can further include forming an opening in the wall of the vessel via instruments that extend through the implantation passageway. The method can include securing the access port to the vessel such that the implantation passageway is in fluid communication with an interior of the vessel via the opening in the wall of the vessel. The method can also include sealing the implantation passageway at the position proximal to the guidance passageway.
FILED	Monday, July 06, 2015
APPL NO	14/792486
ART UNIT	3761 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/0057 (20130101) A61B 17/3423 (20130101) A61B 2017/00641 (20130101) A61B 2017/00654 (20130101) A61B 2017/3425 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/3653 (20130101) Original (OR) Class A61M 1/3659 (20140204) A61M 1/3661 (20140204) A61M 39/0208 (20130101) A61M 2039/0223 (20130101) A61M 2039/0226 (20130101) A61M 2039/0238 (20130101) A61M 2205/0238 (20130101)
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09970127 — Method and apparatus for producing large, single-crystals of aluminum nitride

US 09970127	Schowalter et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Research Laboratory (AFRL) Department of the Navy (DON) Office of Naval Research (ONR) Missile Defense Agency (MDA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Crystal IS, Inc. (Green Island, New York)
ASSIGNEE(S)	CRYSTAL IS, INC. (Green Island, New York)
INVENTOR(S)	Leo Schowalter (Latham, New York); Glen A. Slack (Scotia, New York); Juan Carlos Rojo (South Beach, New York); Robert T. Bondokov (Watervliet, New York); Kenneth E. Morgan (Castleton, New York); Joseph A. Smart (Mooresville, North Carolina)
ABSTRACT	Bulk single crystals of AlN having a diameter greater than about 25 mm and dislocation densities of about 10,000 cm⁻²or less and high-quality AlN substrates having surfaces of any desired crystallographic orientation fabricated from these bulk crystals.
FILED	Monday, August 08, 2016
APPL NO	15/231141
ART UNIT	1785 — Miscellaneous Articles, Stock Material
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 11/003 (20130101) C30B 23/00 (20130101) C30B 23/025 (20130101) C30B 25/10 (20130101) C30B 25/14 (20130101) C30B 25/16 (20130101) Original (OR) Class C30B 25/20 (20130101) C30B 29/403 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/02389 (20130101) H01L 21/02458 (20130101) H01L 21/02634 (20130101) H01L 29/04 (20130101) H01L 29/32 (20130101) H01L 29/205 (20130101) H01L 29/0657 (20130101) H01L 29/2003 (20130101) H01L 29/7787 (20130101) H01L 29/66462 (20130101) H01L 33/12 (20130101) H01L 33/025 (20130101) H01L 33/0075 (20130101) H01L 33/325 (20130101) H01L 2924/00 (20130101) H01L 2924/0002 (20130101) H01L 2924/0002 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/21 (20150115)
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09970969 — Systems, methods, and software for determining spatially variable distributions of the dielectric properties of a heterogeneous material

US 09970969	Farrington
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Transcend Engineering and Technology, LLC (Bethel, Vermont)
ASSIGNEE(S)	Transcend Engineering and Technology, LLC (Bethel, Vermont)
INVENTOR(S)	Stephen P. Farrington (Stockbridge, Vermont)
ABSTRACT	Systems, methods, and software for measuring the spatially variable relative dielectric permittivity of materials along a linear or otherwise configured sensor element, and more specifically the spatial variability of soil moisture in one dimension as inferred from the dielectric profile of the soil matrix surrounding a linear sensor element. Various methods provided herein combine advances in the processing of time domain reflectometry data with innovations in physical sensing apparatuses. These advancements enable high temporal (and thus spatial) resolution of electrical reflectance continuously along an insulated waveguide that is permanently emplaced in contact with adjacent soils. The spatially resolved reflectance is directly related to impedance changes along the waveguide that are dominated by electrical permittivity contrast due to variations in soil moisture. Various methods described herein are thus able to monitor soil moisture in profile with high spatial resolution.
FILED	Thursday, July 30, 2015
APPL NO	14/813929
ART UNIT	2867 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/048 (20130101) G01N 33/246 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 27/06 (20130101) Original (OR) Class
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U.S. State Government

09970034 — Use of marine algae for co-producing alkenones, alkenone derivatives, and co-products

US 09970034	Reddy et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE) U.S. State Government Commonwealth of Massachusetts Massachusetts Clean Energy Center (MassCEC)
APPLICANT(S)	Woods Hole Oceanographic Institution (Woods Hole, Massachusetts); Western Washington University (Bellingham, Washington); Marine Biological Laboratory (Woods Hole, Massachusetts)
ASSIGNEE(S)	Woods Hole Oceanographic Institution (Woods Hole, Massachusetts); Western Washington University (Bellingham, Washington); Marine Biological Laboratory (Woods Hole, Massachusetts)
INVENTOR(S)	Christopher M. Reddy (Woods Hole, Massachusetts); Gregory W. O'Neil (Bellingham, Massachusetts); Scott R. Lindell (Woods Hole, Massachusetts)
ABSTRACT	A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis.
FILED	Saturday, January 17, 2015
APPL NO	14/599460
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Heterocyclic Compounds C07D 303/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) C12P 7/649 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/13 (20130101)
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09971001 — Volume array coil with enforced uniform element currents for improved excitation homogeneity

US 09971001	McDougall et al.
FUNDED BY	U.S. State Government State of Texas Cancer Prevention and Research Institute of Texas (TX-CPRIT)
APPLICANT(S)	The Texas A and M University System (College Station, Texas)
ASSIGNEE(S)	The Texas A and M University System (College Station, Texas)
INVENTOR(S)	Mary P. McDougall (College Station, Texas); Steven M. Wright (College Station, Texas)
ABSTRACT	Each of the coils in a transmit coil array of a magnetic resonance imaging apparatus is electrically connected to a common voltage point by a transmission line. By controlling the electrical length of the transmission line connecting each of the coils to the common voltage point to an odd integer multiple of one quarter wavelength, the current delivered to each coil is independent of coil impedance. This principle of forced current excitation enables equal currents to be delivered to each coil of a magnetic resonance imaging transmit coil array regardless of the unique loading of the individual coils and mutual impedance between the coils.
FILED	Wednesday, November 28, 2012
APPL NO	13/687863
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/34 (20130101) Original (OR) Class G01R 33/36 (20130101) G01R 33/34046 (20130101)
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Department of Homeland Security (DHS)

09970879 — Aparatus and method of determining a reaction sensitivity threshold of materials to elecrostatic discharge

US 09970879	Hernandez et al.
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	The United States of America, as Represented by the Secretary, Department of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	David Hernandez (Ato, New Jersey); David Hoey (Lynn Haven, Florida); Joseph Eugene Chipuk, Jr. (Charlottesville, Virginia); Benjamin Ostrow (Mays Landing, New Jersey)
ABSTRACT	A method and apparatus for determining the sensitivity to electrostatic discharge (ESD) of energetic and volatile samples. The method and apparatus include an optical detector configured to detect the optical light intensity from an ESD event with time resolution less than 15 microseconds. The optical light intensity is integrated to obtain an integrated light intensity. The method and apparatus further include processing circuitry configured to determine whether the ESD event is a “Go” event, wherein the energetic material undergoes decomposition generating additional light in addition to light generated by the ESD event itself, or the ESD event is a “No-Go” event without decomposition of the energetic/volatile material. The integrated light intensity threshold between “Go” and “No-Go” events is determined using a statistical distribution of inert sample measurements.
FILED	Wednesday, September 23, 2015
APPL NO	14/863090
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/67 (20130101) Original (OR) Class G01N 33/227 (20130101)
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Department of Transportation (USDOT)

09972850 — Fuel cell component having dimensions selected to maximize a useful area

US 09972850	O'Neill et al.
FUNDED BY	Department of Transportation (USDOT)
APPLICANT(S)	Jonathan Daniel O'Neill (Manchester, Connecticut); Timothy W. Patterson (West Hartford, Connecticut)
ASSIGNEE(S)	Audi AG (Ingolstadt, Germany)
INVENTOR(S)	Jonathan Daniel O'Neill (Manchester, Connecticut); Timothy W. Patterson (West Hartford, Connecticut)
ABSTRACT	An exemplary fuel cell component includes a generally planar body having a total area defined by a length and width of the body. A first portion of the total area is occupied by a first fuel cell features that renders the first portion unusable for at least one fuel cell function. A second portion of the total area is occupied by a second fuel cell feature that renders the second portion unusable for the fuel cell function. A third portion of the total area is considered an active area of the component that is useful for the fuel cell function. An aspect ratio of the length to the width of the generally planar body is dependent on a dimension of the first portion and a dimension of the second portion.
FILED	Tuesday, June 05, 2012
APPL NO	14/405136
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/026 (20130101) H01M 8/242 (20130101) H01M 8/0247 (20130101) H01M 8/0258 (20130101) H01M 8/0265 (20130101) Original (OR) Class H01M 8/0267 (20130101) H01M 8/0271 (20130101) H01M 8/0273 (20130101) H01M 8/04007 (20130101) H01M 8/04082 (20130101)
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National Security Agency (NSA)

09973218 — Circuits to enable reconfigurability

US 09973218	Zhu et al.
FUNDED BY	National Security Agency (NSA) Maryland Procurement Office (MPO)
APPLICANT(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	Kehan Zhu (Palo Alto, California); Cheng Li (Palo Alto, California); Zhubiao Zhu (Fort Collins, Colorado)
ABSTRACT	An example device in accordance with an aspect of the present disclosure includes at least one segment driver circuit having a first circuit and a second circuit, to receive input signals and provide output signals. A given segment driver circuit is to protect reliability and enable reconfigurability by selectively resetting coupling capacitors, and selectively cutting off the input signals from their respective segment driver circuit.
FILED	Thursday, September 15, 2016
APPL NO	15/266574
ART UNIT	2632 — Digital Communications
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/0427 (20130101) Pulse Technique H03K 17/6872 (20130101) H03K 19/017509 (20130101) Transmission H04B 1/04 (20130101) Original (OR) Class H04B 10/541 (20130101) H04B 10/801 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/04 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Smithsonian Institution (SI)

09970915 — Systems and methods for rapid measurement of carbon dioxide in water

US 09970915	Miller et al.
FUNDED BY	Smithsonian Institution (SI)
APPLICANT(S)	Smithsonian Environmental Research Center (Edgewater, Maryland)
ASSIGNEE(S)	Smithsonian Institution (Washington, District of Columbia)
INVENTOR(S)	Alexander Whitman Miller (Annapolis, Maryland); Gerhardt F. Riedel (Saint Leonards, Maryland); Karl John Klug (West Hollywood, California)
ABSTRACT	Systems and methods are provided for rapidly determining the partial pressure of CO₂(pCO₂) in a body of water. The systems and methods are particularly useful for measuring p CO₂in coastal waters and other bodies of water where pCO₂can change rapidly and vary widely at sites that are in close proximity to each other. Additionally, pCO₂measurements can be important for industrial CO₂sequestration monitoring, monitoring pCO₂in wastewater and drinking water treatment plants, as well as monitoring and controlling pH in municipal and private swimming pools.
FILED	Tuesday, November 10, 2015
APPL NO	14/937331
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/10 (20130101) G01N 1/2273 (20130101) G01N 7/00 (20130101) G01N 21/3504 (20130101) G01N 33/004 (20130101) Original (OR) Class G01N 33/1886 (20130101) G01N 2201/0221 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

09968672 — IDNA vaccines and methods for using the same

US 09968672	Pushko et al.
FUNDED BY
APPLICANT(S)	Medigen, Inc. (Frederick, Maryland)
ASSIGNEE(S)	MEDIGEN, INC. (Frederick, Maryland)
INVENTOR(S)	Peter Pushko (Frederick, Maryland); Igor Lukashevich (Cockeysville, Maryland)
ABSTRACT	Described herein are iDNA vectors and vaccines and methods for using the same. The iDNA generates live attenuated vaccines in eukaryotic cells in vitro or in vivo for pathogenic RNA viruses, particularly yellow fever virus and Venezuelan equine encephalitis virus. When iDNA is injected into the vaccine recipient, RNA of live attenuated virus is generated by in vivo transcription in the recipient's tissues. This initiates production of progeny attenuated viruses in the tissues of the vaccine recipient, as well as elicitation of an effective immune response protecting against wild-type, non-attenuated virus.
FILED	Thursday, January 30, 2014
APPL NO	14/168788
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/193 (20130101) Original (OR) Class A61K 2039/53 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/85 (20130101) C12N 2770/24134 (20130101) C12N 2770/24161 (20130101) C12N 2770/36134 (20130101) C12N 2770/36161 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

09970545 — Stern tube seal system

US 09970545	Cutler et al.
FUNDED BY
APPLICANT(S)	Mide Technology Corporation (Medford, Massachusetts)
ASSIGNEE(S)	Mide Technology Corporation (Medford, Massachusetts)
INVENTOR(S)	Andrew Cutler (Seattle, Washington); Stephen Hanly (Charlestown, Massachusetts); Steven A. Klepper (Stoneham, Massachusetts); Christopher Ludlow (Melrose, Massachusetts); Mark Spadafora (Arlington, Massachusetts); Marthinus van Schoor (Arlington, Massachusetts)
ABSTRACT	A seal system includes a face seal rotor ring including a wide sealing face preferably made of tungsten carbide. The stator ring includes a narrower sealing face confronting the rotor ring wide sealing face. The stator ring sealing face is preferably made of polyamide-imide and tapers to narrower widths rearwardly.
FILED	Thursday, February 02, 2017
APPL NO	15/422892
ART UNIT	3675 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Marine Propulsion or Steering B63H 23/321 (20130101) B63H 2023/327 (20130101) Pistons; Cylinders; Sealings F16J 15/008 (20130101) Original (OR) Class F16J 15/54 (20130101) F16J 15/3204 (20130101) F16J 15/3452 (20130101) F16J 15/3496 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, May 15, 2018.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2018/fedinvent-patents-20180515.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

info@wayfinder.digital