FedInvent™ Patents
Patent Details for Tuesday, August 14, 2018
This page was updated on Monday, March 27, 2023 at 05:36 AM GMT
Department of Health and Human Services (HHS)
| US 10045703 | Rege et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Abhiskek Rege (Baltimore, Maryland); Janaka Senarathna (Baltimore, Maryland); Nitish V. Thakor (Clarksville, Maryland) |
| ABSTRACT | An embodiment in accordance with the present invention provides a system and method for imaging living tissue and processing laser speckle data anisotropically to calculate laser speckle contrast preferentially along the direction of blood flow. In the present invention, raw laser speckle images are obtained and processed resulting in the anisotropic laser speckle images. The system and method involve the determination of the direction of blood flow for every pixel within the region of interest (primary pixel) and subsequent extraction of a set of secondary pixels in the spatio-temporal neighborhood of the primary pixel that is anisotropic in the direction of blood flow. Speckle contrast is then calculated for every primary pixel as the ratio of standard deviation and mean of all secondary pixels in this anisotropic neighborhood and collectively plotted using a suitable color mapping scheme to obtain an anisotropic laser speckle contrast image of the region of interest. |
| FILED | Wednesday, September 26, 2012 |
| APPL NO | 14/346984 |
| ART UNIT | 3768 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/0059 (20130101) A61B 5/0062 (20130101) A61B 5/0066 (20130101) A61B 5/0261 (20130101) Original (OR) Class A61B 5/489 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045728 | Wu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Teresa Wu (Gilbert, Arizona); Min Zhang (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Teresa Wu (Gilbert, Arizona); Min Zhang (Tempe, Arizona) |
| ABSTRACT | Methods and systems for identifying blobs, for example kidney glomeruli, are disclosed. A raw image may be smoothed via a difference of Gaussians filter, and a Hessian analysis may be conducted on the smoothed image to mark glomeruli candidates. Exemplary candidate features are identified, such as average intensity AT, likelihood of blobness RT, and flatness ST. A clustering algorithm may be utilized to post prune the glomeruli candidates. |
| FILED | Monday, March 28, 2016 |
| APPL NO | 15/082095 |
| ART UNIT | 2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/201 (20130101) Original (OR) Class A61B 5/7225 (20130101) A61B 5/7264 (20130101) A61B 2576/02 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/10088 (20130101) G06T 2207/30084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045741 | Tisdall et al. |
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| FUNDED BY |
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| APPLICANT(S) | Matthew Tisdall (Somerville, Massachusetts); Andre van der Kouwe (Woburn, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Matthew Tisdall (Somerville, Massachusetts); Andre van der Kouwe (Woburn, Massachusetts) |
| ABSTRACT | Systems and methods for estimating frequency drifts in magnetic resonance signals acquired with a magnetic resonance imaging (“MRI”) system are provided. In one example, the frequency drifts are estimated from phase-correction data that are obtained during an echo-planar imaging (“EPI”), or other multiecho imaging, scan. The systems and methods of the present invention provide for efficiently and accurately computing frequency drift values that can be used for real-time, prospective frequency drift correction. |
| FILED | Friday, August 01, 2014 |
| APPL NO | 14/449297 |
| ART UNIT | 2866 — Printing/Measuring and Testing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/0816 (20130101) A61B 5/7203 (20130101) A61B 5/7285 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/565 (20130101) G01R 33/5616 (20130101) G01R 33/56509 (20130101) G01R 33/56518 (20130101) G01R 33/56563 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045765 | Rafiee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Nasser Rafiee (Andover, Massachusetts); Stuart MacDonald (Andover, Massachusetts); Robert J. Lederman (Chevy Chase, Maryland); Toby Rogers (Bethesda, Maryland); Rany Busold (Andover, Massachusetts); Koosha Rafiee (Andover, Massachusetts) |
| ASSIGNEE(S) | Transmural Systems LLC (Andover, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Nasser Rafiee (Andover, Massachusetts); Stuart MacDonald (Andover, Massachusetts); Robert J. Lederman (Chevy Chase, Maryland); Toby Rogers (Bethesda, Maryland); Rany Busold (Andover, Massachusetts); Koosha Rafiee (Andover, Massachusetts) |
| ABSTRACT | The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls. |
| FILED | Monday, July 31, 2017 |
| APPL NO | 15/664642 |
| ART UNIT | 3731 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/0057 (20130101) Original (OR) Class A61B 17/1215 (20130101) A61B 17/12122 (20130101) A61B 17/12145 (20130101) A61B 2017/00247 (20130101) A61B 2017/00606 (20130101) A61B 2017/00623 (20130101) A61B 2017/00991 (20130101) A61B 2017/3425 (20130101) A61B 2090/376 (20160201) A61B 2090/3966 (20160201) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/0077 (20130101) A61F 2/88 (20130101) A61F 2/90 (20130101) A61F 2/966 (20130101) A61F 2230/0078 (20130101) A61F 2230/0091 (20130101) A61F 2250/0098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045865 | Veatch |
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| FUNDED BY |
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| APPLICANT(S) | Invisible Hand Enterprises, LLC (Westminster, Colorado) |
| ASSIGNEE(S) | INVISIBLE HAND ENTERPRISES, LLC (Westminster, Colorado) |
| INVENTOR(S) | Bradley Delton Veatch (Westminster, Colorado) |
| ABSTRACT | This disclosure relates to the field of prosthetics, more specifically to a pinless anthropomorphic hinge or joint, and a digit comprising one or more phalanges connected by and articulating around pinless joints, whereby the joints provide compliant movement in more than one plane. This disclosure also relates to modular prosthetic systems comprising multiple digits, in particular for partial-hand replacements. |
| FILED | Monday, September 26, 2016 |
| APPL NO | 15/276753 |
| ART UNIT | 3738 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/68 (20130101) A61F 2/583 (20130101) A61F 2/586 (20130101) Original (OR) Class A61F 2002/5093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045882 | Balicki et al. |
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| FUNDED BY |
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| APPLICANT(S) | Marcin A. Balicki (Baltimore, Maryland); Russell H. Taylor (Severna Park, Maryland); Jin U. Kang (Ellicott City, Maryland); Peter L. Gehlbach (Hunt Valley, Maryland); James T. Handa (Baltimore, Maryland); Jaeho Han (Columbia, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Marcin A. Balicki (Baltimore, Maryland); Russell H. Taylor (Severna Park, Maryland); Jin U. Kang (Ellicott City, Maryland); Peter L. Gehlbach (Hunt Valley, Maryland); James T. Handa (Baltimore, Maryland); Jaeho Han (Columbia, Maryland) |
| ABSTRACT | A surgical instrument has a surgical tool that has a proximal end and a distal end, and an optical sensor that has at least a portion attached to the surgical tool. The surgical tool has a portion that is suitable to provide a reference portion of the surgical tool, and the optical sensor has an end fixed relative to the reference portion of the surgical tool such that the reference portion of the surgical tool can be detected along with tissue that is proximate or in contact with the distal end of the surgical tool while in use. |
| FILED | Monday, November 01, 2010 |
| APPL NO | 12/917168 |
| ART UNIT | 3731 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/102 (20130101) A61B 3/1005 (20130101) A61B 3/1225 (20130101) A61B 34/30 (20160201) A61B 34/75 (20160201) A61B 34/76 (20160201) A61B 90/361 (20160201) A61B 2090/061 (20160201) A61B 2090/3735 (20160201) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00727 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045947 | Bencherif et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sidi A. Bencherif (Dorchester, Massachusetts); David J. Mooney (Sudbury, Massachusetts); David Edwards (Boston, Massachusetts); Roger Warren Sands (Chicago, Illinois) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Sidi A. Bencherif (Dorchester, Massachusetts); David J. Mooney (Sudbury, Massachusetts); David Edwards (Boston, Massachusetts); Roger Warren Sands (Chicago, Illinois) |
| ABSTRACT | The invention provides polymer compositions for cell and drug delivery. |
| FILED | Friday, April 27, 2012 |
| APPL NO | 14/112096 |
| ART UNIT | 1619 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/7007 (20130101) Original (OR) Class A61K 39/0011 (20130101) A61K 2039/64 (20130101) A61K 2039/55522 (20130101) A61K 2039/55561 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/20 (20130101) A61L 27/50 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 2300/64 (20130101) A61L 2300/252 (20130101) A61L 2300/258 (20130101) A61L 2400/06 (20130101) A61L 2400/16 (20130101) A61L 2430/34 (20130101) Compositions of Macromolecular Compounds C08L 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045951 | Christofidou-Solomidou |
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| FUNDED BY |
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| APPLICANT(S) | Melpo Christofidou-Solomidou (Eagleville, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Melpo Christofidou-Solomidou (Eagleville, Pennsylvania) |
| ABSTRACT | The invention relates compositions and methods for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans. Specifically, the invention relates to the dietary use of flaxseed lignans. |
| FILED | Monday, April 11, 2011 |
| APPL NO | 13/084408 |
| ART UNIT | 1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/065 (20130101) Original (OR) Class A61K 31/365 (20130101) A61K 31/7032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045961 | Chang et al. |
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| FUNDED BY |
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| APPLICANT(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Jinhong Chang (Chalfont, Pennsylvania); Fang Guo (Doylestown, Pennsylvania); Timothy M. Block (Doylestown, Pennsylvania); Ju-Tao Guo (Lansdale, Pennsylvania) |
| ABSTRACT | Provided herein are methods of treating a subject having hepatitis B viral (HBV) infection. More specifically, disclosed herein are methods of stimulating the innate cytokine response in macrophages, dendritic cells and/or liver non-parenchymal cells with small molecular agonists of STING to suppress HBV replication in hepatocytes. The methods are especially suitable for use in the treatment of chronic HBV infections. Also disclosed herein are methods of identifying compounds useful in the treatment of HBV infection. |
| FILED | Monday, April 10, 2017 |
| APPL NO | 15/483645 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class A61K 31/473 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/706 (20130101) C12Q 2600/136 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5067 (20130101) G01N 2333/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045963 | Tyavanagimatt et al. |
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| FUNDED BY |
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| APPLICANT(S) | SIGA TECHNOLOGIES, INC. (Corvallis, Oregon) |
| ASSIGNEE(S) | SIGA TECHNOLOGIES, INC. (Corvallis, Oregon) |
| INVENTOR(S) | Shanthakumar R. Tyavanagimatt (Corvallis, Oregon); N K Peter Samuel (Corvallis, Oregon); Joseph Paz (Corvallis, Oregon); Ying Tan (Walnut Creek, California); Dennis E. Hruby (Albany, Oregon) |
| ABSTRACT | Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide. |
| FILED | Tuesday, January 02, 2018 |
| APPL NO | 15/860262 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1694 (20130101) A61K 31/4035 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/32 (20130101) A61K 47/38 (20130101) Heterocyclic Compounds C07D 209/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045964 | Tyavanagimatt et al. |
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| FUNDED BY |
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| APPLICANT(S) | Siga Technologies, Inc. (Corvallis, Oregon) |
| ASSIGNEE(S) | Siga Technologies Inc. (Corvallis, Oregon) |
| INVENTOR(S) | Shanthakumar R. Tyavanagimatt (Sammamish, Washington); Melialani A. C. L. S. Anderson (Corvallis, Oregon); William C. Weimers (Corvallis, Oregon); Dylan Nelson (Corvallis, Oregon); Tove' C. Bolken (Keizer, Oregon); Dennis E. Hruby (Albany, Oregon); Michael H. O'Neill (Painesville, Ohio); Gary Sweetapple (Madison, Ohio); Kelley A. McCloughan (South Haven, Michigan) |
| ABSTRACT | Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions. |
| FILED | Thursday, July 27, 2017 |
| APPL NO | 15/661194 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1652 (20130101) A61K 9/4866 (20130101) A61K 31/404 (20130101) Original (OR) Class Heterocyclic Compounds C07D 209/70 (20130101) C07D 209/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045966 | Skaar et al. |
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| APPLICANT(S) | Vanderbilt Univeristy (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Eric P. Skaar (Brentwood, Tennessee); Laura Anzaldi Mike (Nashville, Tennessee); Gary Sulikowski (Brentwood, Tennessee); Alex Waterson (Murfreesboro, Tennessee); Paul Reid (Nashville, Tennessee) |
| ABSTRACT | Embodiments of the presently-disclosed subject matter include activators of HssRS that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting S. aureus, including clinically relevant small colony variants (SCVs). The utility of targeting fermenting bacteria is exemplified by the fact that this compound prevents the emergence of antibiotic resistance, enhances phagocyte killing, and reduces S. aureus pathogenesis. This small molecule is a powerful tool not only for studying bacterial heme biosynthesis and central metabolism, but also establishes targeting of fermentation as a viable antibacterial strategy. |
| FILED | Friday, April 21, 2017 |
| APPL NO | 15/494148 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/7008 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045970 | Castro et al. |
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| FUNDED BY |
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| APPLICANT(S) | Infinity Pharmaceuticals, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Infinity Pharmaceuticals, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Alfredo C. Castro (Winchester, Massachusetts); Michael J. Grogan (Winchester, Massachusetts); Karen J. McGovern (Groton, Massachusetts); Martin R. Tremblay (Melrose, Massachusetts) |
| ABSTRACT | The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula: |
| FILED | Tuesday, May 02, 2017 |
| APPL NO | 15/585038 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/17 (20130101) A61K 31/56 (20130101) A61K 31/58 (20130101) A61K 31/69 (20130101) A61K 31/196 (20130101) A61K 31/198 (20130101) A61K 31/454 (20130101) A61K 31/519 (20130101) A61K 31/573 (20130101) A61K 31/664 (20130101) A61K 31/704 (20130101) A61K 31/4355 (20130101) Original (OR) Class A61K 31/4745 (20130101) A61K 31/7068 (20130101) A61K 31/7076 (20130101) A61K 38/21 (20130101) A61K 45/06 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Heterocyclic Compounds C07D 307/94 (20130101) C07D 471/04 (20130101) C07D 471/10 (20130101) C07D 491/04 (20130101) C07D 491/10 (20130101) C07D 491/048 (20130101) C07D 491/107 (20130101) Steroids C07J 69/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10045989 | Lambeth et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | John David Lambeth (Decatur, Georgia); Thota Ganesh (Alpharetta, Georgia); Susan M. Smith (Acworth, Georgia); Aiming Sun (Atlanta, Georgia) |
| ABSTRACT | The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or myeloperoxidase. |
| FILED | Thursday, May 05, 2016 |
| APPL NO | 15/147531 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/4953 (20130101) A61K 31/517 (20130101) Original (OR) Class Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101) A61Q 19/00 (20130101) A61Q 19/08 (20130101) Heterocyclic Compounds C07D 239/78 (20130101) C07D 239/95 (20130101) C07D 401/06 (20130101) C07D 403/06 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046001 | Lee et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
| INVENTOR(S) | Richard K. Lee (Miami, Florida); Sanjoy K. Bhattacharya (North Bay Village, Florida) |
| ABSTRACT | Compositions, kits, and methods for reducing intraocular pressure (IOP) in a subject (e.g., human) include at least one naturally occurring or synthesized version or analog thereof of a lipid (e.g., a phosphoserine, a phosphocholine, a psychosine or other glycolipid) that is endogenous to non-glaucomatous aqueous humor in a subject and that lowers IOP in the subject, in a therapeutically effective amount for promoting aqueous outflow through TM in at least one eye of the subject and reducing IOP in the subject. The compositions can be used for, e.g., treating glaucomas, including, for example, primary open angle glaucoma (POAG) and normal tension glaucoma (NTG). |
| FILED | Thursday, December 04, 2014 |
| APPL NO | 15/102201 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/557 (20130101) A61K 31/557 (20130101) A61K 31/661 (20130101) A61K 31/675 (20130101) Original (OR) Class A61K 31/683 (20130101) A61K 31/683 (20130101) A61K 31/685 (20130101) A61K 31/685 (20130101) A61K 31/688 (20130101) A61K 31/688 (20130101) A61K 45/06 (20130101) A61K 47/10 (20130101) A61K 47/20 (20130101) A61K 47/22 (20130101) A61K 47/24 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046002 | Zebala et al. |
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| FUNDED BY |
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| APPLICANT(S) | SYNTRIX BIOSYSTEMS INC. (Auburn, Washington) |
| ASSIGNEE(S) | SYNTRIX BIOSYSTEMS INC. (Auburn, Washington) |
| INVENTOR(S) | John A. Zebala (Issaquah, Washington); Dean Y. Maeda (Seattle, Washington); Aaron D. Schuler (Auburn, Washington) |
| ABSTRACT | What is described is a method for treating cancer in a patient in need of such treatment through the use of an antagonist to CXCR1 and/or CXCR2 receptors by administering a therapeutically effective amount of an antagonist of CXCR1 and/or CXCR2, or pharmaceutical compositions thereof, either alone as monotherapy, or in combination with at least one other anticancer therapy. |
| FILED | Thursday, November 17, 2016 |
| APPL NO | 15/354936 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/0053 (20130101) A61K 9/0095 (20130101) A61K 9/1652 (20130101) A61K 31/69 (20130101) Original (OR) Class A61K 31/69 (20130101) A61K 31/282 (20130101) A61K 31/495 (20130101) A61K 35/17 (20130101) A61K 39/0011 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 47/38 (20130101) A61K 2035/124 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) Peptides C07K 16/2818 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/57492 (20130101) G01N 2333/521 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046011 | Shi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| INVENTOR(S) | Yufang Shi (Belle Mead, New Jersey); Guangwen Ren (Piscataway, New Jersey); Liying Zhang (Belle Mead, New Jersey) |
| ABSTRACT | The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs). |
| FILED | Saturday, December 14, 2013 |
| APPL NO | 14/652324 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 35/28 (20130101) A61K 38/191 (20130101) A61K 38/191 (20130101) A61K 38/217 (20130101) A61K 38/217 (20130101) A61K 38/2006 (20130101) A61K 38/2006 (20130101) A61K 45/06 (20130101) A61K 2035/122 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) C12N 2500/05 (20130101) C12N 2501/10 (20130101) C12N 2501/24 (20130101) C12N 2501/25 (20130101) C12N 2501/2301 (20130101) C12N 2501/2317 (20130101) C12N 2502/1114 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046012 | Shi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Songtao Shi (Los Angeles, California); Byoung-Moo Seo (Seoul, South Korea); Masako Miura (Kyoto, Japan) |
| ABSTRACT | The invention generally relates to postnatal periodontal ligament stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal periodontal ligament multipotent stem cells, use of the cells to generate periodontium, differentiation of the cells and methods of tissue cryopreservation. |
| FILED | Monday, November 09, 2015 |
| APPL NO | 14/936529 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/02 (20130101) A01N 1/0205 (20130101) A01N 1/0221 (20130101) Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 8/0006 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0063 (20130101) A61K 35/32 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3834 (20130101) A61L 27/3865 (20130101) A61L 27/3895 (20130101) A61L 2300/64 (20130101) A61L 2300/412 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0664 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046023 | Blumberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts); BIOGEN MA INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts); BIOGEN MA INC. (Boston, Massachusetts) |
| INVENTOR(S) | Richard S. Blumberg (Waltham, Massachusetts); Timo Rath (Cambridge, Massachusetts); Kristi Baker (Brookline, Massachusetts); Adam Mezo (Carmel, Indiana); Zachary Taylor (Crestview Hills, Kentucky); Kevin McDonnell (Lexington, Massachusetts); Rosa Maria Silva Garcia Grenha (Arlington, Massachusetts) |
| ABSTRACT | The invention provided herein includes isolated polypeptides that specifically block the interaction between neonatal Fc receptor (FcRn) and albumin. Blocking the interaction treats diseases and conditions caused by increased amounts of albumin or modified albumin that possesses pathogenic properties wherein it is deemed desirable to decrease albumin levels. Accordingly, also provided are methods of using these isolated polypeptides to treat various diseases and conditions caused by increased amounts of albumin or modified albumin that possesses pathogenic properties. The invention provided herein also includes isolated polypeptides capable of binding to a non-IgG and non-albumin competitive site on an FcRn alpha 3 domain. These can be useful for tracking FcRn without inhibiting IgG or albumin binding or function. Accordingly, the invention also includes methods and systems to track FcRn without inhibiting IgG or albumin binding or function. |
| FILED | Thursday, November 17, 2016 |
| APPL NO | 15/354375 |
| ART UNIT | 1675 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) Original (OR) Class A61K 47/48023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046024 | Spaller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | The United States of America, as represented by National Institutes of Health (NIH), U.S. Dept of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resource (DEITR) (Washington, District of Columbia) |
| INVENTOR(S) | Mark Spaller (Lebanon, New Hampshire); John Marshall (Providence, Rhode Island); Dennis J. Goebel (Detroit, Michigan) |
| ABSTRACT | A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising wherein R is a molecular transporter with or without a linker amino acid; R1 is at least about one amino acid covalently bound; and, R2 is isoleucine, leucine, alanine, phenylalanine, or valine, and methods of use. |
| FILED | Tuesday, June 28, 2016 |
| APPL NO | 15/195366 |
| ART UNIT | 1675 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/006 (20130101) A61K 9/0019 (20130101) A61K 9/0034 (20130101) A61K 9/0085 (20130101) A61K 31/42 (20130101) A61K 31/42 (20130101) A61K 31/135 (20130101) A61K 31/135 (20130101) A61K 31/198 (20130101) A61K 31/198 (20130101) A61K 31/395 (20130101) A61K 31/395 (20130101) A61K 31/401 (20130101) A61K 31/401 (20130101) A61K 38/00 (20130101) A61K 38/12 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 7/56 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2982 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
10046026 — Papillomavirus-like particles (VLP) as broad spectrum human papillomavirus (HPV) vaccines
| US 10046026 | Roden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Richard B. S. Roden (Saverna Park, Maryland); Reinhard Kirnbauer (Sooss, Austria); Christina Schellenbacher (Zeiselmauer-Wolfpassing, Austria) |
| ABSTRACT | This invention relates, e.g., to a virus-like particle (VLP) composition assembled from a chimeric polypeptide comprising a papilloma virus (e.g., human papillomavirus, or HPV) L1 major capsid protein, into which is inserted a surface-displayed peptide comprising a neutralizing epitope of a papillomavirus L2 protein. Vaccine compositions comprising the VLP are described, as well as methods for inducing an immune response (e.g., vaccinating) a subject against papilloma virus, using the VLP, and kits comprising the VLP, for carrying out a method of the invention. |
| FILED | Monday, October 05, 2015 |
| APPL NO | 14/875374 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 2039/5258 (20130101) A61K 2039/55505 (20130101) A61K 2039/55566 (20130101) A61K 2039/55572 (20130101) Peptides C07K 14/005 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/20023 (20130101) C12N 2710/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046030 | Petri, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | William A. Petri, Jr. (Charlottesville, Virginia); Erica Buonomo (Malden, Massachusetts) |
| ABSTRACT | The present invention encompasses compositions and methods useful to treat or prevent Clostridium difficile antibiotic-associated colitis through administration of IL-25 and/or downstream cytokines IL-13, IL-4, and IL-5. It is disclosed herein that IL-25 expression is decreased during antibiotic treatment and during bacterial infection and that treatment with IL-25 protein is protective during infection. It is further disclosed herein the unexpected result that IL-25 treatment protects against C. difficile-associated mortality and morbidity. The present application further describes an unexpected result regarding eosinophils and their role in combating infection and their relationship to the effectiveness of IL-25. |
| FILED | Wednesday, October 07, 2015 |
| APPL NO | 15/517191 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/733 (20130101) A61K 31/4164 (20130101) A61K 35/747 (20130101) A61K 38/20 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2035/115 (20130101) Peptides C07K 14/54 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046040 | Galen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | James E. Galen (Sykesville, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| INVENTOR(S) | James E. Galen (Sykesville, Maryland) |
| ABSTRACT | The invention relates to a multivalent Clostridium difficile vaccine comprising a Salmonella Typhi live vector comprising the cell binding domain of TcdA toxin (CBD/A) of Clostridium difficile or an antigenic fragment thereof and the cell binding domain of TcdB toxin (CBD/B) of Clostridium difficile or an antigenic fragment thereof and optionally the cell-binding subunit component (CdtB) of binary toxin of Clostridium difficile or an antigenic fragment thereof. The invention further provides methods of inducing an immune response and methods of preventing recurrence of C. difficile infections in subjects. |
| FILED | Tuesday, November 16, 2010 |
| APPL NO | 13/509818 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/08 (20130101) Original (OR) Class A61K 2039/522 (20130101) A61K 2039/523 (20130101) A61K 2039/541 (20130101) A61K 2039/545 (20130101) A61K 2039/55505 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046043 | Granoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL and RESEARCH CENTER AT OAKLAND (Oakland, California) |
| ASSIGNEE(S) | CHILDREN'S HOSPITAL and RESEARCH CENTER AT OAKLAND (Oakland, California) |
| INVENTOR(S) | Dan M. Granoff (Berkeley, California); Victor Chen-Hsi Hou (Bethlehem, Pennsylvania) |
| ABSTRACT | The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis serogroup B strain. |
| FILED | Monday, August 15, 2016 |
| APPL NO | 15/237495 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 39/095 (20130101) Original (OR) Class A61K 2039/522 (20130101) A61K 2039/575 (20130101) Peptides C07K 14/22 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 530/825 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046045 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| INVENTOR(S) | Janet L. Smith (Ann Arbor, Michigan); David L. Akey (Ann Arbor, Michigan); W. Clay Brown (Chelsea, Michigan); Richard J Kuhn (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to nonstructural protein 1 (NS1) from flaviviruses and uses thereof. In particular, the present invention relates to diagnostic and therapeutic uses of NS1 to treat and prevent disease caused by flaviviruses. |
| FILED | Friday, December 19, 2014 |
| APPL NO | 15/106085 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24122 (20130101) C12N 2770/24134 (20130101) C12N 2770/24171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046050 | Wall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| ASSIGNEE(S) | UNIVERSITY OF TENESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| INVENTOR(S) | Jonathan S. Wall (Knoxville, Tennessee); Stephen J. Kennel (Kingston, Tennessee); James S. Foster (Knoxville, Tennessee) |
| ABSTRACT | Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to the amyloid-reactive peptides are then administered to the subject. Upon administration of the antibodies, the amyloid-reactive peptides bind the antibodies and thus pre-target the antibodies to the amyloid deposits. In other examples, an amyloid-reactive fusion peptide contains an epitope of a known antibody. When the fusion peptide is administered to a subject, the fusion peptide binds amyloids in the subject. Administration to the subject of the known antibody that binds the epitope of the fusion peptide then targets the antibody to the amyloid deposit to which the fusion peptide is bound. |
| FILED | Wednesday, February 24, 2016 |
| APPL NO | 15/052772 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1716 (20130101) A61K 39/39583 (20130101) Original (OR) Class A61K 47/48346 (20130101) A61K 47/48723 (20130101) A61K 2039/545 (20130101) Peptides C07K 14/4711 (20130101) C07K 16/18 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046053 | Purcell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Brendan Patrick Purcell (Brooklyn, New York); Jason Alan Burdick (Philadelphia, Pennsylvania) |
| ABSTRACT | The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme. |
| FILED | Wednesday, June 21, 2017 |
| APPL NO | 15/628766 |
| ART UNIT | 1675 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 38/10 (20130101) A61K 38/57 (20130101) A61K 38/1866 (20130101) A61K 47/24 (20130101) A61K 47/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046057 | Tatro et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Erick T. Tatro (San Diego, California); Nathan Gianneschi (San Diego, California); Anthony M. Rush (San Diego, California) |
| ABSTRACT | There are disclosed compositions and methods to render nucleic acids resistant to nuclease digestion while maintaining sequence selective hybridization competency. The approach relies on utilizing nucleic acids as the polar head group of a nucleic acid-polymer amphiphile in order to assemble well-defined, discrete micellar nanoparticles. Dense packing of nucleic acid in the micelle corona allows for hybridization of complementary oligonucleotides while prohibiting enzymatic degradation. |
| FILED | Tuesday, March 24, 2015 |
| APPL NO | 14/667283 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/48176 (20130101) Original (OR) Class A61K 48/0041 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/87 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/113 (20130101) C12N 2310/351 (20130101) C12N 2310/353 (20130101) C12N 2310/3231 (20130101) C12N 2310/3515 (20130101) C12N 2320/32 (20130101) C12N 2320/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046068 | Hecht et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents, for and on behalf of, Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Sidney Hecht (Phoenix, Arizona); Manikandadas Mathilakathu Madathil (Tempe, Arizona); Chandrabali Bhattacharya (Tempe, Arizona); Trevor Bozeman (Tempe, Arizona); Rakesh Paul (Baltimore, Maryland); Zhiqiang Yu (Tempe, Arizona); Michael J. Rishel (Saratoga Springs, New York) |
| ABSTRACT | This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors. |
| FILED | Friday, March 14, 2014 |
| APPL NO | 14/776578 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 47/545 (20170801) A61K 47/6925 (20170801) A61K 49/0002 (20130101) A61K 49/0032 (20130101) A61K 49/0052 (20130101) Original (OR) Class A61K 49/0054 (20130101) A61K 49/223 (20130101) A61K 51/065 (20130101) A61K 51/0497 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046086 | Guelcher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Scott A. Guelcher (Thompsons Station, Tennessee); Madison McGough (Nashville, Tennessee); Mukesh K. Gupta (Nashville, Tennessee); Craig L. Duvall (Nashville, Tennessee); John Martin (Nashville, Tennessee); Jon Page (Mount Juliet, Tennessee) |
| ABSTRACT | A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. The low-molecular weight thioketal includes 2,2-dimethoxypropane and thioglycolic acid, wherein the thioketal includes at least two hydroxyl terminal groups. The method of forming the biodegradable scaffold includes blending a thioketal with an excess isocyanate, forming a quasi-prepolymer, mixing the thioketal, the quasi-prepolymer, and a ceramic, and then adding a catalyst to form the biodegradable scaffold. The thioketal is a low-molecular weight thioketal having at least two hydroxyl terminal groups. |
| FILED | Tuesday, October 11, 2016 |
| APPL NO | 15/290875 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/425 (20130101) A61L 2400/06 (20130101) A61L 2430/02 (20130101) Acyclic or Carbocyclic Compounds C07C 323/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/771 (20130101) C08G 18/2063 (20130101) C08G 18/3868 (20130101) C08G 2230/00 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046174 | Deisseroth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Karl Deisseroth (Stanford, California); Alexander Aravanis (San Diego, California); Feng Zhang (Cambridge, Massachusetts); M. Bret Schneider (Portola Valley, California); Jaimie M. Henderson (Stanford, California) |
| ABSTRACT | In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells. |
| FILED | Wednesday, March 20, 2013 |
| APPL NO | 13/847785 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 36/05 (20130101) A61K 38/16 (20130101) A61K 41/0057 (20130101) A61K 48/005 (20130101) A61K 48/0058 (20130101) A61K 48/0083 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 5/0601 (20130101) A61N 5/0622 (20130101) Original (OR) Class A61N 2005/063 (20130101) A61N 2005/0651 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10043 (20130101) C12N 2710/16643 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
10047052 — Bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use
| US 10047052 | Amaravadi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Ravi K. Amaravadi (Media, Pennsylvania); Jeffrey Winkler (Wynnewood, Pennsylvania) |
| ABSTRACT | The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and/or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention. Methods of treating disease states and/or conditions in which inhibition of autophagy plays a favorable treatment role including rheumatoid arthritis, malaria, antiphospholipid antibody syndrome, lupus, chronic urticaria and Sjogren's disease, with compounds according to the present invention represent additional aspects of the invention. |
| FILED | Tuesday, December 20, 2016 |
| APPL NO | 15/384823 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 215/46 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047105 | Creighton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Merck Sharp and Dohme Corp. (Rahway, New Jersey) |
| ASSIGNEE(S) | Merck Sharp and Dohme Corp. (Rahway, New Jersey) |
| INVENTOR(S) | Christopher J. Creighton (San Diego, California); Leslie William Tari (San Diego, California); Zhiyong Chen (San Diego, California); Mark Hilgers (San Diego, California); Thanh To Lam (San Diego, California); Xiaoming Li (San Diego, California); Michael Trzoss (San Diego, California); Junhu Zhang (San Diego, California); John Finn (San Diego, California); Daniel Bensen (Carlsbad, California) |
| ABSTRACT | Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth. Compounds of Formula (I), are disclosed: Formula (I), wherein Y is N or CH; Z is N or CR5; R5 is H, a substituted or unsubstituted hydrocarbyl residue (1-3C) containing 0-2 heteroatoms selected from O, S and N, or is an inorganic residue; L is O, S, NR7, or CR8R9; R7 is H or C1-3 alkyl; R8 and R9 are each independently H or C1-3 alkyl; R2 is H, a hydrocarbyl residue (1-40C) containing 0-10 heteroatoms selected from O, S and N optionally substituted with an inorganic residue; R4 is H, an inorganic residue, or a hydrocarbyl residue (1-30C) containing 0-12 heteroatoms selected from O, S and N and containing 0-10 inorganic residues, wherein R5 and R4 together may join to form a fused ring; and R6 is selected from the group consisting of H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, halo C1-5 alkyl, halo C2-5 alkenyl, halo C2-5 alkynyl, C1-5 hydroxyalkyl, C1-5 alkyl chloride, C2-5 alkenyl chloride, and C2-5 alkynyl chloride; or a pharmaceutically-acceptable salt, ester, or prodrug thereof. |
| FILED | Friday, September 16, 2016 |
| APPL NO | 15/267978 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) C07D 471/16 (20130101) C07D 487/04 (20130101) C07D 487/16 (20130101) C07D 491/048 (20130101) C07D 513/04 (20130101) C07D 519/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047114 | Iyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SPRING BANK PHARMACEUTICALS, INC. (Milford, Massachusetts) |
| ASSIGNEE(S) | Spring Bank Pharmaceuticals, Inc. (Milford, Massachusetts) |
| INVENTOR(S) | Radhakrishnan P. Iyer (Shrewsbury, Massachusetts); Seetharamaiyer Padmanabhan (Lexington, Massachusetts) |
| ABSTRACT | The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. |
| FILED | Thursday, November 12, 2015 |
| APPL NO | 14/939397 |
| ART UNIT | 1673 — Plants |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7076 (20130101) A61K 31/7084 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/20 (20130101) Original (OR) Class C07H 21/04 (20130101) Steroids C07J 17/00 (20130101) C07J 43/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047119 | Cosford et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford-Burnham Medical Research Institute (La Jolla, California) |
| ASSIGNEE(S) | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (La Jolla, California) |
| INVENTOR(S) | Nicholas David Peter Cosford (La Jolla, California); Mitchell Dennis Vamos (La Jolla, California) |
| ABSTRACT | Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPB), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. |
| FILED | Tuesday, November 29, 2016 |
| APPL NO | 15/363935 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Heterocyclic Compounds C07D 487/04 (20130101) C07D 487/14 (20130101) C07D 498/04 (20130101) C07D 498/10 (20130101) C07D 513/04 (20130101) Peptides C07K 5/0806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047122 | Qian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Wenjian Qian (Frederick, Maryland); Jung Eun Park (Bethesda, Maryland); Christopher C. Lai (Ellicott City, Maryland); James A. Kelley (Silver Spring, Maryland); Kyung S. Lee (Gaithersburg, Maryland); Terrence R. Burke, Jr. (Bethesda, Maryland) |
| ABSTRACT | The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected phophoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents. |
| FILED | Friday, March 14, 2014 |
| APPL NO | 14/776512 |
| ART UNIT | 1675 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/005 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/1411 (20130101) C07F 9/4071 (20130101) Peptides C07K 1/061 (20130101) C07K 7/06 (20130101) Original (OR) Class C07K 2319/21 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047128 | Judd et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | Justin Judd (Houston, Texas); Junghae Suh (Houston, Texas); Jonathan Silberg (Houston, Texas) |
| ABSTRACT | The present invention is a peptide lock that comprises at least one peptide that is genetically encoded into the Adeno-associated virus (AAV) capsid that block biologically active domains on the virus capsid surface. The peptide lock, can be processed by biological enzymes to restore biological behavior of the capsid-displayed domains, thus ‘decoding the lock’ or opening the lock. A method of forming the peptide lock comprises providing at least one peptide, providing an Adeno-associated virus capsid and genetically inserting the at least one peptide into the Adeno-associated virus capsid to block the biologically active domains on the virus capsid surface. |
| FILED | Monday, April 29, 2013 |
| APPL NO | 13/872949 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/33 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2750/14122 (20130101) C12N 2750/14145 (20130101) C12N 2810/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047129 | Barrall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELECTRONIC BIOSCIENCES, INC. (San Diego, California) |
| ASSIGNEE(S) | ELECTRONIC BIOSCIENCES, INC. (San Diego, California) |
| INVENTOR(S) | Geoffrey A. Barrall (San Diego, California); Eric N. Ervin (Salt lake City, Utah); Prithwish Pal (San Diego, California) |
| ABSTRACT | Provided herein are alpha hemolysin polypeptides comprising modified amino acid sequences that can reduce the rate of translocation of a polymer. Also provided herein are apparatuses and devices comprising modified hemolysin polypeptides. Also provided herein are methods of using modified alpha hemolysin proteins for use in characterizing and/or sequencing a polymer or for use as molecular sensors. |
| FILED | Thursday, December 19, 2013 |
| APPL NO | 14/653246 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 14/31 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/143333 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047130 | Corbo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | WASHINGTON UNIVERSITY (Saint Louis, Missouri) |
| INVENTOR(S) | Joseph C. Corbo (St. Louis, Missouri); Jennifer Enright (St. Louis, Missouri); Matthew Toomey (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides compositions and methods used for optogenetics, wherein the composition comprises an optogenetic device and a retinoid processing enzyme. |
| FILED | Wednesday, March 18, 2015 |
| APPL NO | 15/127337 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/405 (20130101) Original (OR) Class C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0008 (20130101) C12N 9/0071 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101) Enzymes C12Y 102/01036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047135 | Miao |
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| FUNDED BY |
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| APPLICANT(S) | STC.UNM (Albuquerque, North Carolina) |
| ASSIGNEE(S) | STC.UNM (Albuquerque, New Mexico) |
| INVENTOR(S) | Yubin Miao (Albuquerque, New Mexico) |
| ABSTRACT | The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. |
| FILED | Friday, February 13, 2015 |
| APPL NO | 14/622217 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) A61K 51/08 (20130101) A61K 51/086 (20130101) A61K 51/088 (20130101) Peptides C07K 7/54 (20130101) C07K 14/68 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047140 | Ingber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Donald E. Ingber (Boston, Massachusetts); Mariko Kobayashi (Brookline, Massachusetts) |
| ABSTRACT | TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number of pathological conditions, e.g., edema, inflammation, hypertension, and/or hyperalgesia. Described herein are methods and compositions relating to inhibition of mechanically-induced TRPV4 activation, e.g., for the treatment of pulmonary edema, edema, inflammation, hypertension, and/or hyperalgesia. |
| FILED | Tuesday, June 24, 2014 |
| APPL NO | 14/900265 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/705 (20130101) C07K 14/70596 (20130101) Original (OR) Class C07K 2319/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047146 | Mouquet et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE ROCKEFELLER UNIVERSITY (New York, New York); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Hugo Mouquet (New York, New York); Michel Nussenzweig (New York, New York); Pamela J. Bjorkman (La Canada Flintridge, California); Louise Scharf (Porter Ranch, California) |
| ABSTRACT | The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide. |
| FILED | Friday, October 18, 2013 |
| APPL NO | 14/436608 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/1045 (20130101) Original (OR) Class C07K 16/1063 (20130101) C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047147 | Connors et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of American, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Mark Connors (Bethesda, Maryland); Jinghe Huang (Bethesda, Maryland); Leo Laub (Richmond, Virginia); John Mascola (Rockville, Maryland); Nancy Longo (Kensington, Maryland); Nicole Doria-Rose (Kensington, Maryland) |
| ABSTRACT | Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection. |
| FILED | Monday, August 04, 2014 |
| APPL NO | 14/450773 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) A61K 49/0004 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/00 (20130101) C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/21 (20130101) C07K 2317/31 (20130101) C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) G01N 33/56983 (20130101) G01N 33/56988 (20130101) G01N 2333/161 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047148 | Connors et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Mark Connors (Bethesda, Maryland); Jinghe Huang (Bethesda, Maryland); Leo B. Laub (Richmond, Virginia); Peter Kwong (Washington, District of Columbia); Gary Nabel (Cambridge, Massachusetts); John R. Mascola (Rockville, Maryland); Baoshan Zhang (Bethesda, Maryland); Rebecca S. Rudicell (Silver Springs, Maryland); Ivelin Georgiev (Gaithersburg, Maryland); Yongping Yang (Potomac, Maryland); Jiang Zhu (Ashburn, Virginia); Gilad Ofek (Washington, District of Columbia) |
| ABSTRACT | Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection. |
| FILED | Friday, September 08, 2017 |
| APPL NO | 15/699902 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) A61K 49/0004 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/00 (20130101) C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/21 (20130101) C07K 2317/31 (20130101) C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) G01N 33/56983 (20130101) G01N 33/56988 (20130101) G01N 2333/161 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047149 | Schneewind et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Olaf Schneewind (Chicago, Illinois); Dominique M. Missiakas (Chicago, Illinois); Hwan Keun Kim (Naperville, Illinois); Carla Emolo (Chicago, Illinois); Andrea DeDent (Chicago, Illinois) |
| ABSTRACT | Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA). |
| FILED | Tuesday, December 13, 2016 |
| APPL NO | 15/377050 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/40 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) Peptides C07K 16/1271 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/21 (20130101) C07K 2317/51 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) C07K 2317/569 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 2333/31 (20130101) G01N 2500/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047346 | Ikeda et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yasuhiro Ikeda (Rochester, Minnesota); Andre Terzic (Rochester, Minnesota); Timothy J. Nelson (Rochester, Minnesota); Amber A. Mael (Madison, Wisconsin); Almudena J. Martinez Fernandez (Rochester, Minnesota); Satsuki Yamada (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Yasuhiro Ikeda (Rochester, Minnesota); Andre Terzic (Rochester, Minnesota); Timothy J. Nelson (Rochester, Minnesota); Amber A. Mael (Madison, Wisconsin); Almudena J. Martinez Fernandez (Rochester, Minnesota); Satsuki Yamada (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided. |
| FILED | Monday, August 10, 2009 |
| APPL NO | 13/058154 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) Original (OR) Class C12N 2500/90 (20130101) C12N 2500/98 (20130101) C12N 2501/602 (20130101) C12N 2501/603 (20130101) C12N 2501/604 (20130101) C12N 2501/605 (20130101) C12N 2501/606 (20130101) C12N 2501/608 (20130101) C12N 2510/00 (20130101) C12N 2740/16043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047355 | Yin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Hao Yin (Cambridge, Massachusetts); Wen Xue (Cambridge, Massachusetts); Daniel G. Anderson (Framingham, Massachusetts); Joseph R. Dorkin (Somerville, Massachusetts); Tyler E. Jacks (Newton, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods for modifying a gene sequence, and for systems for delivering such compositions. For example, the disclosure relates to modifying a gene sequence using a CRISPR-Cas9 or other nucleic acid editing system, and methods and delivery systems for achieving such gene modification, such as viral or non-viral delivery systems. |
| FILED | Friday, December 09, 2016 |
| APPL NO | 15/374227 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/85 (20130101) C12N 15/86 (20130101) C12N 15/88 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047365 | Williams |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NATURE TECHNOLOGY CORPORATION (Lincoln, Nebraska) |
| ASSIGNEE(S) | NATURE TECHNOLOGY CORPORATION (Lincoln, Nebraska) |
| INVENTOR(S) | James A. Williams (Lincoln, Nebraska) |
| ABSTRACT | The present invention relates to the production and use of covalently closed circular (ccc) recombinant DNA molecules such as plasmids, cosmids, bacterial artificial chromosomes (BACs), bacteriophages, viral vectors and hybrids thereof, and more particularly to vector modifications that improve expression of these DNA molecules. |
| FILED | Monday, November 18, 2013 |
| APPL NO | 14/432693 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/79 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2820/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047386 | Cai |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Hua Cai (Los Angeles, California) |
| ABSTRACT | Methods for detecting abdominal aortic aneurysm (AAA) or predisposition to AAA in a apoE subject, methods for monitoring the efficacy of treatment of AAA in a subject, and methods for evaluating the severity of AAA or risk of AAA in a subject involve measuring the amount of tetrahydrobiopterin (H4B) present in the test sample and comparing it to the amount of H4B present in a standard or previous test sample. A decreased amount of H4B present in the test sample compared to the standard is indicative of AAA or predisposition to AAA. Treatment can be administered to the subject prior to a second time point, and an increased amount of H4B present in the second test sample compared to the first test sample is indicative of effective treatment of AAA. Candidates can be identified for further testing or monitoring for AAA, and/or for treatment for AAA. |
| FILED | Thursday, October 11, 2012 |
| APPL NO | 14/349828 |
| ART UNIT | 1677 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/008 (20130101) Original (OR) Class C12Q 1/37 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5735 (20130101) G01N 33/6893 (20130101) G01N 2800/50 (20130101) G01N 2800/56 (20130101) G01N 2800/329 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/147777 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047392 | Ivankin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | Northeastern University (Boston, Massachusetts) |
| INVENTOR(S) | Andrey Ivankin (Chicago, Illinois); Joseph Larkin (Dorchester, Massachusetts); Robert Henley (Boston, Massachusetts); Meni Wanunu (Boston, Massachusetts) |
| ABSTRACT | Described herein are systems for analysis of biopolymers and complexes containing biopolymers based on optical measurement of ion flux through pores. Also described are methods of using such devices for analysis of biopolymers and complexes containing biopolymers, including methods of determining the nucleotide sequences of polynucleotides. |
| FILED | Monday, February 23, 2015 |
| APPL NO | 15/119859 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 2521/543 (20130101) C12Q 2563/137 (20130101) C12Q 2565/631 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6408 (20130101) G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 33/48721 (20130101) G01N 2021/6439 (20130101) G01N 2021/7786 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047396 | Sharp et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Frank Sharp (Davis, California); Xinhua Zhan (Vacaville, California); Glen C. Jickling (Sacramento, California); S. Claiborne Johnston (San Francisco, California) |
| ABSTRACT | The present invention provides methods and compositions for diagnosing and predicting the risk and cause of transient ischemic attacks (TIA). |
| FILED | Sunday, February 14, 2016 |
| APPL NO | 15/043577 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/37 (20130101) A61K 31/616 (20130101) A61K 31/727 (20130101) A61K 31/4365 (20130101) A61K 31/4439 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2800/2871 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047399 | Ting et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio) |
| ASSIGNEE(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio) |
| INVENTOR(S) | Angela H. Ting (Cleveland, Ohio); Byron H. Lee (Cleveland, Ohio) |
| ABSTRACT | A method of providing a prognosis or diagnosis of prostate cancer in a subject is described. The method includes obtaining a urine or prostate sample from the subject; determining the level of expression of ABCA1 in the sample; and comparing the level of expression of ABCA1 in the sample to the level of a control sample, wherein a decreased level of ABCA1 expression compared to the control indicates the subject has prostate cancer or a more severe form of prostate cancer. Methods of treating subjects identified as having prostate cancer, and kits for carrying out the method of prognosis or diagnosis are also described. |
| FILED | Monday, January 06, 2014 |
| APPL NO | 14/148241 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/154 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57434 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047400 | Dave et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Sandeep Dave (Chapel Hill, North Carolina); Cassandra Love (Durham, North Carolina) |
| ABSTRACT | Disclosed are nucleic acid sequences, including microRNA sequences and cDNA sequences, as well as vectors, DNA libraries, microarrays, and recombinant cells comprising the nucleic acid sequences described herein. Methods of determining the B cell stage from which a B cell malignancy is derived. Methods of identifying B cell malignancies are also provided. Methods of diagnosing B cell malignancies are provided. Such methods comprise, in certain embodiments, detecting one or more microRNAs or cDNAs as disclosed herein. |
| FILED | Friday, June 27, 2014 |
| APPL NO | 14/317879 |
| ART UNIT | 1674 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047401 | Harris et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Curtis C. Harris (Garrett Park, Maryland); Aaron Joseph Schetter (Germantown, Maryland); Hirokazu Okayama (Rockville, Maryland); Ichiro Akagi (Aizu-Wakamatsu, Japan) |
| ABSTRACT | The invention provides novel biomarkers (four genes BRCA1, HIF1A, DLC1, and XPO1 alone or in combination of miR-21) for early stage lung cancer. |
| FILED | Tuesday, August 20, 2013 |
| APPL NO | 14/423069 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047402 | |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Michael MingZhao Xing (Clarksville, Maryland) |
| ABSTRACT | The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for treating thyroid cancer. In certain embodiments, the method comprises the steps of (a) treating DNA isolated from a sample collected from the patient using bisulfite; (b) measuring the DNA methylation level of the promoter region of the RASAL1 gene from the bisulfite-treated DNA using methylation-specific polymerase chain reaction (MSP), wherein the MSP creates a methylation and unmethylation band; (c) normalizing the measured DNA methylation level using an internal reference gene; (d) calculating the percentage of allelic methylation using the formula [M/(M+U]×100%, wherein M and U represent the density of the methylation and unmethylation band; and (e) predicting an increased risk of thyroid cancer in the subject if the percentage of allelic methylation is at least 40%. |
| FILED | Monday, August 04, 2014 |
| APPL NO | 14/909590 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 48/00 (20130101) Peptides C07K 14/47 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048222 | Agah et al. |
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| FUNDED BY |
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| APPLICANT(S) | Masoud Agah (Blacksburg, Virginia); Shree Narayanan Sreedharan Nair (Hillsboro, Oregon) |
| ASSIGNEE(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| INVENTOR(S) | Masoud Agah (Blacksburg, Virginia); Shree Narayanan Sreedharan Nair (Hillsboro, Oregon) |
| ABSTRACT | The present invention provides an ionization detector having a base having an enclosed chamber. The enclosed chamber has a first end and a second end. The detector also includes a first outlet which is a source of an excitable medium. A second outlet is provided which functions a source of an analyte that is transported by a carrier gas. An ionization source for creating a discharge from said excitable medium is also provided. The collector electrode generates a time dependent current based on its interaction with ionized analytes from which the analyte may be detected. |
| FILED | Friday, October 31, 2014 |
| APPL NO | 14/529760 |
| ART UNIT | 2868 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/68 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048252 | Linder et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Vincent Linder (Tewksbury, Massachusetts); Samuel K. Sia (New York, New York); George M. Whitesides (Newton, Massachusetts) |
| ABSTRACT | A method and apparatus for delivering one or more fluids. Fluids may be delivered from a common vessel to a chemical, biological or biochemical process. |
| FILED | Friday, May 01, 2015 |
| APPL NO | 14/702278 |
| ART UNIT | 1677 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0293 (20130101) B01L 3/5027 (20130101) B01L 3/502784 (20130101) B01L 2300/0816 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) G01N 33/5304 (20130101) Original (OR) Class G01N 35/08 (20130101) G01N 35/1002 (20130101) G01N 35/1065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048254 | Bai |
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| FUNDED BY |
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| APPLICANT(S) | ALBANY MEDICAL COLLEGE (Albany, New York) |
| ASSIGNEE(S) | ALBANY MEDICAL COLLEGE (Albany, New York) |
| INVENTOR(S) | Guangchun Bai (Delmar, New York) |
| ABSTRACT | The present disclosure provides a simple yet fast, cost effective, reliable method for the detection and quantification of cyclic-di-adenosine monophosphate (c-di-AMP) by measuring c-di-AMP binding to a c-di-AMP-binding protein (CabP). A sample is contacted with CabP in the presence of biotin-labeled c-di-AMP. Once binding has reached equilibrium, unbound c-di-AMP is removed and the CabP-bound c-di-AMP is contacted with an enzyme-conjugated biotin-binding protein and a chromogenic substrate to generate a detectable signal. The signal generated correlates to the amount of unlabeled c-di-AMP in the sample. |
| FILED | Tuesday, June 03, 2014 |
| APPL NO | 14/896117 |
| ART UNIT | 1677 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/566 (20130101) G01N 33/5308 (20130101) Original (OR) Class G01N 2333/4703 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048255 | Boyden et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Edward S. Boyden (Chestnut Hill, Massachusetts); Katarzyna P. Adamala (Somerville, Massachusetts); Daniel Alberto Martin-Alarcon (Brookline, Massachusetts) |
| ABSTRACT | A programmable modular protein architecture for RNA binding comprises a set of modules, derived from RNA-binding protein Pumilio, that can be concatenated into chains of varying composition and length. When bound into a chain, each module has a preferred affinity for a specific RNA base. The chains can bind arbitrary RNA sequences with high specificity and fidelity by varying the sequence of modules within the chains. Each module contains at least 6 amino acids, with the amino acids in positions 1 and 5 providing the preferred affinity for the specific base, and the amino acid at position 2 serving as a stacking unit between concatenated modules. The modules may have four canonic forms, each having a preferred affinity for a different base and characterized by the base with which it has affinity, the two amino acids that provide the affinity, and the amino acid that serves as a stacking unit. |
| FILED | Wednesday, January 13, 2016 |
| APPL NO | 14/995169 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 14/47 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048261 | Das et al. |
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| FUNDED BY |
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| APPLICANT(S) | NATIONWIDE CHILDREN'S HOSPITAL, INC. (Columbus, Ohio); THE OHIO STATE UNIVERSITY (Columbus, Ohio) |
| ASSIGNEE(S) | THE OHIO STATE UNIVERSITY (Columbus, Ohio); NATIONWIDE CHILDREN'S HOSPITAL, INC. (Columbus, Ohio) |
| INVENTOR(S) | Subinoy Das (Columbus, Ohio); Lauren O. Bakaletz (Hilliard, Ohio) |
| ABSTRACT | The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract. |
| FILED | Thursday, January 12, 2017 |
| APPL NO | 15/404681 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0045 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) Original (OR) Class G01N 2333/285 (20130101) G01N 2800/12 (20130101) G01N 2800/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048266 | Jaffee et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Elizabeth A. Jaffee (Lutherville, Maryland); Darshil T. Jhaveri (Towson, Maryland); Robert Anders (Parkville, Maryland) |
| ABSTRACT | We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected against these proteins in patients with >3 years disease-free survival indicates the anti-tumor potential of targeting these proteins. We found that tissue expression of proteins PSMC5, TFRC and PPP1R12A increases during tumor development from normal to pre-malignant to pancreatic tumor. In addition, these proteins were shown to be pancreatic cancer-associated antigens that are recognized by post-vaccination antibodies in the sera of patients that received the vaccine and have demonstrated a favorable disease free survival. |
| FILED | Friday, November 10, 2017 |
| APPL NO | 15/809555 |
| ART UNIT | 1677 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) Original (OR) Class G01N 2333/79 (20130101) G01N 2333/705 (20130101) G01N 2333/916 (20130101) G01N 2333/4703 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048271 | Almo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine of Yeshiva University (Bronx, New York) |
| ASSIGNEE(S) | Albert Einstein College of Medicine, Inc. (Bronx, New York) |
| INVENTOR(S) | Steven C. Almo (Pelham, New York); Ronald D. Seidel, III (Larchmont, New York); Brandan S. Hillerich (Larchmont, New York); Sarah C. Garrett-Thomson (New York, New York); James D. Love (New York, New York) |
| ABSTRACT | Methods and systems for high-throughput identification of receptor:ligand interactions are provided. |
| FILED | Thursday, December 05, 2013 |
| APPL NO | 14/649176 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/6845 (20130101) Original (OR) Class G01N 33/54326 (20130101) G01N 33/54366 (20130101) G01N 2015/149 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048272 | Edwards et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | STC.UNM (Albuquerque, New Mexico); TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (Port St Lucie, Florida) |
| ASSIGNEE(S) | STC.UNM (Albuquerque, New Mexico); Torrey Pines Institute for Molecular Studies (Port St. Lucie, Florida) |
| INVENTOR(S) | Bruce S. Edwards (Albuquerque, New Mexico); Larry A. Sklar (Albuquerque, New Mexico); Clemencia Pinilla (Cardiff, California); Richard A. Houghten (Vero Beach, Florida); Jon R. Appel (Cardiff, California); Marc A. Giulianotti (Vero Beach, Florida); Jose Medina-Franco (Port St Lucie, Florida) |
| ABSTRACT | The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders. |
| FILED | Tuesday, February 02, 2016 |
| APPL NO | 15/013102 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/496 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2219/00585 (20130101) Acyclic or Carbocyclic Compounds C07C 275/28 (20130101) Heterocyclic Compounds C07D 241/08 (20130101) C07D 403/14 (20130101) Peptides C07K 1/047 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 33/6845 (20130101) Original (OR) Class G01N 2333/726 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048340 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Phillip Z. Sun (Woburn, Massachusetts); Iris Y. Zhou (Malden, Massachusetts) |
| ABSTRACT | A system and method for creating magnetic resonance images are provided. The system applies an RF irradiation during a saturation time period at a reference frequency that saturates a range of selected labile spin species of the subject. The system encodes frequency offsets by applying a gradient G1 at least during the saturation time period. The system applies a plurality of slice selection gradients accompanied by a train of RF pulses during a voxel selection time period and a gradient G3 during an acquisition time period. One or more spin/gradient echo signals having information pertaining to at least one of metabolites and metabolite byproducts is acquired to form a CEST medical imaging data set and the CEST medical imaging data set is reconstructed to form a CEST image of the subject including information about the at least one of metabolites and metabolite byproducts within the subject. |
| FILED | Friday, June 03, 2016 |
| APPL NO | 15/173599 |
| ART UNIT | 2867 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4833 (20130101) Original (OR) Class G01R 33/5605 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048345 | Magin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Richard Magin (Western Springs, Illinois); Carson Ingo (Chicago, Illinois) |
| ABSTRACT | Disclosed herein is an example method and system for characterizing a biological structure in terms of bio-markers derived from diffusion weighted magnetic resonance imaging (DWI) data of biologic material. A first set of DWI data may be obtained using a fixed diffusion encoding gradient and a plurality of diffusion time resolutions, and a second set of DWI data may be obtained using a fixed diffusion time resolution and a plurality of diffusion encoding gradients. The first and second sets may be analytically fit with a fractional power-law diffusion model parameterized by fractional exponents each uniquely corresponding to one of a plurality of bio-markers of the biologic material. Fractional exponents may be determined from the analytical fitting of the first and second sets of DWI data, and an image of the biologic material may be generated and displayed. |
| FILED | Friday, March 07, 2014 |
| APPL NO | 14/772912 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4064 (20130101) A61B 2576/00 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4818 (20130101) G01R 33/56341 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049447 | Lloyd et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | H. Lee Moffitt Cancer Center and Research Insititute, Inc. (Tampa, Florida) |
| INVENTOR(S) | Mark Cassidy Cridlin Lloyd (Tampa, Florida); Marilyn Yuanxin Ma Bui (Tampa, Florida); Katarzyna Anna Rejniak (Tampa, Florida); Munish Puri (Tampa, Florida) |
| ABSTRACT | Systems and methods for personalized cancer therapy using analysis of pathology slides to target regions in a single sample that interrogates the feature data of a relatively large number of cells. The disclosure describes pathology case review tools of the future which include analysis, visualization and prediction modeling to provide novel information to the pathologist for the diagnosis of disease. This disclosure further describes a user interface to assist the physicians that make that diagnosis, pathologists. Complex computer learning algorithms will combine and mine these data sets to recommend optimal treatment strategies. A computer interface is provided which allows a pathologist to access those data instantly to make a more informed and accurate diagnosis. |
| FILED | Thursday, November 06, 2014 |
| APPL NO | 15/034683 |
| ART UNIT | 2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/00147 (20130101) G06K 9/4604 (20130101) G06K 9/6267 (20130101) G06K 2209/051 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20081 (20130101) G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049450 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | Case Western Reserve University (Cleveland, Ohio) |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Angel Alfonso Cruz Roa (Villavincencio, Colombia); Fabio Gonzalez (Bogota, Colombia) |
| ABSTRACT | Methods, apparatus, and other embodiments associated with classifying a region of tissue represented in a digitized whole slide image (WSI) using iterative gradient-based quasi-Monte Carlo (QMC) sampling. One example apparatus includes an image acquisition circuit that acquires a WSI of a region of tissue demonstrating cancerous pathology, an adaptive sampling circuit that selects a subset of tiles from the WSI using an iterative QMC Sobol sequence sampling approach, an invasiveness circuit that determines a probability of a presence of invasive pathology in a member of the subset of tiles, a probability map circuit that generates an invasiveness probability map based on the probability, a probability gradient circuit that generates a gradient image based on the invasiveness probability map, and a classification circuit that classifies the region of tissue based on the probability map. A prognosis or treatment plan may be provided based on the classification of the WSI. |
| FILED | Friday, September 30, 2016 |
| APPL NO | 15/282233 |
| ART UNIT | 2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0041 (20130101) Electric Digital Data Processing G06F 19/321 (20130101) G06F 19/345 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/4604 (20130101) G06K 9/6269 (20130101) G06K 9/6277 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 10045752 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rajiv Gupta (Wayland, Massachusetts); Luis Fernando Velasquez-Garcia (Cambridge, Massachusetts); Richard Lanza (Cambridge, Massachusetts); Berthold K P Horn (Boston, Massachusetts); Akintunde Ibitayo Akinwande (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Rajiv Gupta (Wayland, Massachusetts); Luis Fernando Velasquez-Garcia (Cambridge, Massachusetts); Richard Lanza (Cambridge, Massachusetts); Berthold K P Horn (Boston, Massachusetts); Akintunde Ibitayo Akinwande (Cambridge, Massachusetts) |
| ABSTRACT | Described here is a method for performing phase contrast imaging using an array of independently controllable x-ray sources. The array of x-ray sources can be controlled to produce a distinct spatial pattern of x-ray radiation and thus can be used to encode phase contrast signals without the need for a coded aperture. The lack of coded aperture increases the flexibility of the imaging method. For instance, because a fixed, coded aperture is not required, the angular resolution of the imaging technique can be increased as compared to coded-aperture imaging. Moreover, the lack of a radioopaque coded aperture increases the photon flux that reaches the subject, thereby increasing the attainable signal-to-noise ratio. |
| FILED | Thursday, March 14, 2013 |
| APPL NO | 14/400703 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/40 (20130101) A61B 6/405 (20130101) A61B 6/484 (20130101) Original (OR) Class A61B 6/4007 (20130101) A61B 6/4405 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/04 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/0016 (20130101) G01V 5/0041 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 2207/005 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 35/12 (20130101) H01J 35/065 (20130101) H01J 2201/30449 (20130101) H01J 2235/062 (20130101) H01J 2235/068 (20130101) H01J 2235/087 (20130101) H01J 2235/186 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046081 | Bowlin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Commonwealth University (Richmond, Virginia); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | The Henry M Jackson Foundation for the Advancement of Military Medicine, Inc. (Rockville, Maryland); Virginia Commonwealth University (Richmond, Virginia) |
| INVENTOR(S) | Gary Bowlin (Mechanicsville, Virginia); David Simpson (Mechanicsville, Virginia); James Bowman (Richmond, Virginia); Stephen Rothwell (Richmond, Virginia) |
| ABSTRACT | The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen. |
| FILED | Tuesday, July 29, 2014 |
| APPL NO | 14/445566 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/28 (20130101) Original (OR) Class A61L 15/28 (20130101) A61L 15/32 (20130101) A61L 15/38 (20130101) A61L 15/44 (20130101) A61L 2300/252 (20130101) A61L 2300/254 (20130101) A61L 2300/418 (20130101) A61L 2400/04 (20130101) Compositions of Macromolecular Compounds C08L 5/02 (20130101) Technical Subjects Covered by Former US Classification Y10T 156/10 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046086 | Guelcher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Scott A. Guelcher (Thompsons Station, Tennessee); Madison McGough (Nashville, Tennessee); Mukesh K. Gupta (Nashville, Tennessee); Craig L. Duvall (Nashville, Tennessee); John Martin (Nashville, Tennessee); Jon Page (Mount Juliet, Tennessee) |
| ABSTRACT | A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. The low-molecular weight thioketal includes 2,2-dimethoxypropane and thioglycolic acid, wherein the thioketal includes at least two hydroxyl terminal groups. The method of forming the biodegradable scaffold includes blending a thioketal with an excess isocyanate, forming a quasi-prepolymer, mixing the thioketal, the quasi-prepolymer, and a ceramic, and then adding a catalyst to form the biodegradable scaffold. The thioketal is a low-molecular weight thioketal having at least two hydroxyl terminal groups. |
| FILED | Tuesday, October 11, 2016 |
| APPL NO | 15/290875 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/425 (20130101) A61L 2400/06 (20130101) A61L 2430/02 (20130101) Acyclic or Carbocyclic Compounds C07C 323/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/771 (20130101) C08G 18/2063 (20130101) C08G 18/3868 (20130101) C08G 2230/00 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046293 | Woodbury et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA (Scottsdale, Arizona) |
| INVENTOR(S) | Neal Woodbury (Tempe, Arizona); Stephen Albert Johnston (Tempe, Arizona) |
| ABSTRACT | Provided herein are methods and devices for performing in situ patterned chemistry for synthesizing and preparing peptide arrays. The invention provides a reproducible and scalable platform that can be potentially used to monitor the health of a plurality of individuals. |
| FILED | Thursday, October 17, 2013 |
| APPL NO | 14/436465 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class B01J 2219/00596 (20130101) B01J 2219/00722 (20130101) B01J 2219/00725 (20130101) Peptides C07K 1/047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046394 | Nassar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| INVENTOR(S) | Abdalla R. Nassar (University Park, Pennsylvania); Edward W. Reutzel (University Park, Pennsylvania) |
| ABSTRACT | A method for manufacturing material voxel-by-voxel using directed-energy deposition is given. Using the method, unsupported structures, via voxel-wise directed-energy deposition, with steep overhangs is described and demonstrated. Methods for forming arbitrarily-complex structures and shaped voxels and surfaces are also given. A method for forming materials with internally-varying properties is also given. The method utilizes a pulsed or modulated, rather than continuous-wave energy source, thus allowing rapid solidification of voxels, rather than contours, hatches or tracks. Tuning of pulsing or modulation, material flow, and deposition-path parameters allows the buildup of unsupported material using standard directed-energy deposition processing heads and 3-axis stages, for example. The methods are demonstrated using a modified-directed-energy-deposition processes and is applicable to powder-bed for the buildup of three-dimensional components, repair and the addition of features to existing components. |
| FILED | Monday, September 14, 2015 |
| APPL NO | 14/852928 |
| ART UNIT | 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1055 (20130101) Original (OR) Class B22F 2003/1057 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 67/0077 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/295 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046463 | Jones et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Anthony D. Jones (San Diego, California); Wayne P. Liu (San Diego, California) |
| ABSTRACT | A base member comprising a vertical fin member, a vertical fin stopper surface, a trigger arm recess, and a base guidance slot. A left jaw member comprising a left jaw portion, a left lever portion, a left guidance slot, a left fastening hole, and a trigger release screw. A right jaw member comprising a right jaw portion, a right lever portion, and a right guidance slot. A trigger arm member comprising a trigger hook and a curved trigger end. A top member comprising a top guidance slot, a left spring hole, a right spring hole, a left bottom recess, a right bottom recess, a left spring recess, and a right spring recess. A left spring tension screw received through the left spring hole and a left spring spacer retained in the left spring recess. A bumper member with a bumper surface, a left elongated member, and a right elongated member. |
| FILED | Friday, February 23, 2018 |
| APPL NO | 15/903140 |
| ART UNIT | 3652 — Material and Article Handling |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 15/0028 (20130101) Original (OR) Class Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/001 (20130101) B63G 2008/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047127 | Demirel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| INVENTOR(S) | Melik Demirel (State College, Pennsylvania); Benjamin Allen (State College, Pennsylvania); Huihun Jung (State College, Pennsylvania) |
| ABSTRACT | Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming subsequences form crystallites comprising stacks of one or more β-sheets and the amorphous subsequences form a network of hydrogen bonds. The supramolecular polypeptides are capable of exhibiting self-healing behavior. |
| FILED | Wednesday, August 23, 2017 |
| APPL NO | 15/683842 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 14/00 (20130101) Original (OR) Class C07K 14/43504 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047135 | Miao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | STC.UNM (Albuquerque, North Carolina) |
| ASSIGNEE(S) | STC.UNM (Albuquerque, New Mexico) |
| INVENTOR(S) | Yubin Miao (Albuquerque, New Mexico) |
| ABSTRACT | The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. |
| FILED | Friday, February 13, 2015 |
| APPL NO | 14/622217 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) A61K 51/08 (20130101) A61K 51/086 (20130101) A61K 51/088 (20130101) Peptides C07K 7/54 (20130101) C07K 14/68 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047309 | Harvey |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA as represented by the SECRETARY of the NAVY (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Benjamin G Harvey (Ridgecrest, California) |
| ABSTRACT | A method for making high density fuels including, providing pure cyclic hydrocarbons or a mixture of cyclic hydrocarbons, subjecting the cyclic hydrocarbons or mixture of cyclic hydrocarbons to electrochemical cycloaddition in the presence of at least one catalyst to generate multicyclic oligomers, and purifying the multicyclic oligomer to yield a high density fuel. |
| FILED | Wednesday, June 08, 2016 |
| APPL NO | 15/176870 |
| ART UNIT | 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 2/42 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/04 (20130101) C10L 1/1608 (20130101) Original (OR) Class C10L 2290/24 (20130101) C10L 2290/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047375 | Thess |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CureVac AG (Tübingen, Germany) |
| ASSIGNEE(S) | CureVac AG (Tübingen, Germany) |
| INVENTOR(S) | Andreas Thess (Kusterdingen, Germany) |
| ABSTRACT | The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3′-untranslated region element (3′-UTR) element comprising a nucleic acid sequence which is derived from the 3′-UTR of a ribosomal protein gene. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, the invention relates to the use of a 3′-UTR element comprising a nucleic acid sequence which is derived from the 3′-UTR of a ribosomal protein gene for enhancing, stabilizing and/or prolonging protein expression from a nucleic acid sequence comprising such 3′-UTR element. |
| FILED | Tuesday, June 28, 2016 |
| APPL NO | 15/195934 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/85 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047405 | Kotula et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jonathan Kotula (Somerville, Massachusetts); Scott Jordan Kerns (Cambridge, Massachusetts); Jeffrey Charles Way (Cambridge, Massachusetts); Pamela A. Silver (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure relates to genetic engineered bacteria having a genetic memory circuit, compositions thereof, formulations thereof, methods of analyses and method of treatment of conditions related to the gastrointestinal tract including the mouth and the stomach. |
| FILED | Friday, December 19, 2014 |
| APPL NO | 15/103372 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/73 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047443 | Krauss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Todd Krauss (Pittsford, New York); Kara L. Bren (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Todd Krauss (Pittsford, New York); Kara L. Bren (Rochester, New York) |
| ABSTRACT | Methods for producing hydrogen using nanoparticles, a catalyst, and a source of electrons, such as bacteria and their nutrient source in a biological system, are carried out in an aqueous medium. The nanoparticles may be doped with a plurality of isovalent and/or non-isovalent dopants. |
| FILED | Tuesday, January 27, 2015 |
| APPL NO | 14/606784 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/755 (20130101) Non-metallic Elements; Compounds Thereof; C01B 2203/1058 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) C25B 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047629 | McCaffrey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United Technologies Corporation (Hartford, Connecticut) |
| ASSIGNEE(S) | United Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Michael G. McCaffrey (Windsor, Connecticut); Tracy A. Propheter-Hinckley (Manchester, Connecticut); Raymond Surace (Newington, Connecticut); Brandon W. Spangler (Vernon, Connecticut) |
| ABSTRACT | An assembly for a turbine engine includes a plurality of vane segments. The vane segments are fastened together and form an adjustable stator vane that pivots about a variable vane axis. The adjustable stator vane includes a stator vane body, a shaft and a flange. The stator vane body extends axially between a first end and a second end, and includes an airfoil, a body surface and a cavity. The body surface is located at the first end. The cavity extends axially from an inlet in the body surface and into the airfoil. The shaft extends along the variable vane axis from the first end. The flange extends circumferentially at least partially around the inlet, and radially from the stator vane body. A first of the vane segments includes the flange. A second of the vane segments includes at least a portion of the airfoil. |
| FILED | Monday, January 28, 2013 |
| APPL NO | 14/763719 |
| ART UNIT | 3748 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/147 (20130101) F01D 9/04 (20130101) F01D 9/065 (20130101) F01D 17/16 (20130101) Original (OR) Class F01D 17/162 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 9/22 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/201 (20130101) F05D 2260/202 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047649 | Lucas |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United Technologies Corporation (Hartford, Connecticut) |
| ASSIGNEE(S) | United Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | James L. Lucas (Hamden, Connecticut) |
| ABSTRACT | Aspects of the disclosure are directed to a shaft configured with a first hole, a bearing race coupled to the shaft and configured with a second hole and a third hole, and an oil scoop configured to receive oil and provide the oil to the shaft, where the first and second holes are oriented axially with respect to the shaft, and where the third hole is oriented radially with respect to the shaft. In some embodiments, a second oil scoop is configured to receive oil and provide the oil to the shall. The oil scoop and the second oil scoop may be concentric with respect to one another. |
| FILED | Monday, June 29, 2015 |
| APPL NO | 14/754124 |
| ART UNIT | 3654 — Material and Article Handling |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/18 (20130101) F01D 25/186 (20130101) Lubricating of Machines or Engines in General; Lubricating Internal Combustion Engines; Crankcase Ventilating F01M 9/06 (20130101) Original (OR) Class F01M 11/02 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/06 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 3/02 (20130101) F16C 19/06 (20130101) F16C 33/6659 (20130101) F16C 33/6677 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047731 | Deshpande et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Nishkamraj U. Deshpande (Novi, Michigan); H. Fred Barsun (Bloomington, Indiana); Steven D. Clark (Bloomfield, Indiana) |
| ABSTRACT | Systems and methods for improving plasma propellant ablation/sublimation based systems are provided. One set of embodiments provides systems and methods for reducing carbon charring during plasma system (e.g., a plasma coating application system) propellant (e.g., a carbon-fluorine polymer) ablation and increasing heat transfer, ablation, and plasma thrust from plasma systems. In particular, one embodiment can include using a nano or micro-sized magnetic or electromagnetic field responsive material as particulates or microcapsules that are intermixed with polytetrafluoroethylene (e.g., Teflon®) nano-fibers, and using resulting fiber composites as the propellant material. Embodiments can include improved plasma system, e.g., pulsed plasma thrusters, plasma torches, plasma coating systems, etc, as well as nozzle improvements such as embodiments with magnetic structures disposed in relation to the nozzle. Alternative embodiments also include recovery and reuse systems. |
| FILED | Wednesday, June 10, 2015 |
| APPL NO | 14/735774 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Producing a Reactive Propulsive Thrust, Not Otherwise Provided for F03H 1/0012 (20130101) F03H 1/0087 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048221 | Dressick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Walter J. Dressick (Waldorf, Maryland); Scott A. Trammell (Springfield, Virginia); Lisa C. Shriver-Lake (Gaithersburg, Maryland) |
| ABSTRACT | A method of detecting chlorate in soil includes contacting soil wetted with a solvent containing an electrically conductive salt with an electrode comprising layers of vanadium-substituted phosphomolybdate alternating with layers of para-rosaniline, and performing voltammetry with the electrode, wherein a catalytic reduction current indicates a likelihood of the presence or absence of chlorate in the soil. A system includes a potentiostat operably connected to the electrode and in communication with hardware and software sufficient to produce an output indicating a chlorate level in soil. |
| FILED | Monday, April 02, 2018 |
| APPL NO | 15/943167 |
| ART UNIT | 1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/30 (20130101) G01N 27/48 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048272 | Edwards et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | STC.UNM (Albuquerque, New Mexico); TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (Port St Lucie, Florida) |
| ASSIGNEE(S) | STC.UNM (Albuquerque, New Mexico); Torrey Pines Institute for Molecular Studies (Port St. Lucie, Florida) |
| INVENTOR(S) | Bruce S. Edwards (Albuquerque, New Mexico); Larry A. Sklar (Albuquerque, New Mexico); Clemencia Pinilla (Cardiff, California); Richard A. Houghten (Vero Beach, Florida); Jon R. Appel (Cardiff, California); Marc A. Giulianotti (Vero Beach, Florida); Jose Medina-Franco (Port St Lucie, Florida) |
| ABSTRACT | The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders. |
| FILED | Tuesday, February 02, 2016 |
| APPL NO | 15/013102 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/496 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2219/00585 (20130101) Acyclic or Carbocyclic Compounds C07C 275/28 (20130101) Heterocyclic Compounds C07D 241/08 (20130101) C07D 403/14 (20130101) Peptides C07K 1/047 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 33/6845 (20130101) Original (OR) Class G01N 2333/726 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048372 | Prater, Jr. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | James L. Prater, Jr. (Panama City, Florida) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | James L. Prater, Jr. (Panama City, Florida) |
| ABSTRACT | To evaluate the resolution of individual sonar images in field conditions without specific targets, a statistical sampling of the imagery is taken and analyzed. Large quantities of resolution measurements are made on point-objects identified in the imagery. The measurements are compared to improve fidelity and generate statistically significant results. The image is broken into segments for analysis to identify variation in resolution across the image. The mean value of point-target resolution per segment can be determined for the imagery. A segment with an insufficient number of measurements required to determine a statistically significant value for resolution is rejected. The image resolution can be determined as the mean or median value of the segment measurements for the entire image. |
| FILED | Friday, April 15, 2016 |
| APPL NO | 15/130111 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/89 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048501 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Magic Leap, Inc. (Plantation, Florida) |
| ASSIGNEE(S) | Magic Leap, Inc. (Plantation, Florida) |
| INVENTOR(S) | Chunyu Gao (Tucson, Arizona); Yuxiang Lin (Tucson, Arizona); Hong Hua (Tucson, Arizona) |
| ABSTRACT | The present invention comprises a compact optical see-through head-mounted display capable of combining, a see-through image path with a virtual image path such that the opaqueness of the see-through image path can be modulated and the virtual image occludes parts of the see-through image and vice versa. |
| FILED | Wednesday, December 06, 2017 |
| APPL NO | 15/833945 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 13/06 (20130101) G02B 25/001 (20130101) G02B 27/144 (20130101) G02B 27/0172 (20130101) Original (OR) Class G02B 27/283 (20130101) G02B 27/1066 (20130101) G02B 2027/015 (20130101) G02B 2027/0118 (20130101) G02B 2027/0145 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 37/02 (20130101) Image Data Processing or Generation, in General G06T 19/006 (20130101) Pictorial Communication, e.g Television H04N 5/2258 (20130101) H04N 5/23238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048703 | Shaker et al. |
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| FUNDED BY |
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| APPLICANT(S) | Adam Shaker (King George, Virginia); Andrew Czop (Alexandria, Virginia); Aaron O'Toole (Indian Head, Maryland); Carlos Ramos Garcia (King George, Virginia) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Adam Shaker (King George, Virginia); Andrew Czop (Alexandria, Virginia); Aaron O'Toole (Indian Head, Maryland); Carlos Ramos Garcia (King George, Virginia) |
| ABSTRACT | A force feedback cuff system, method, and apparatus may include receiving force feedback signal from an external, remotely controlled device; processing the force feedback signal to determine a correlated amount of pressure; applying a correlated signal to air pump equipment to inflate or deflate an inflatable cuff on an operator; and continuing the receiving, processing, and applying while the operator controls the external, remotely controlled device to provide haptic feedback to the operator in an intuitive and non-obtrusive fashion. |
| FILED | Friday, June 06, 2014 |
| APPL NO | 14/120577 |
| ART UNIT | 2115 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 16/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048736 | Eastep et al. |
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| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Jonathan M. Eastep (Portland, Oregon); Richard J. Greco (West Linn, Oregon) |
| ABSTRACT | Methods and apparatus to provide holistic global performance and power management are described. In an embodiment, logic (e.g., coupled to each compute node of a plurality of compute nodes) causes determination of a policy for power and performance management across the plurality of compute nodes. The policy is coordinated across the plurality of compute nodes to manage a job to one or more objective functions, where the job includes a plurality of tasks that are to run concurrently on the plurality of compute nodes. Other embodiments are also disclosed and claimed. |
| FILED | Monday, December 22, 2014 |
| APPL NO | 14/580150 |
| ART UNIT | 2193 — Interprocess Communication and Software Development |
| CURRENT CPC | Electric Digital Data Processing G06F 1/189 (20130101) G06F 1/3203 (20130101) Original (OR) Class G06F 9/4893 (20130101) G06F 9/5094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048738 | Ardanaz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Federico Ardanaz (Hillsboro, Oregon); Jonathan Eastep (Portland, Oregon); Richard Greco (West Linn, Oregon) |
| ABSTRACT | Apparatus and methods may provide for a central power control unit to grant a power allowance to each of a plurality of computer components and to allocate a shared power pool locally accessible to each of the plurality of computer components when one or more of the plurality of components needs to exceed its granted power allowance. |
| FILED | Thursday, March 03, 2016 |
| APPL NO | 15/060326 |
| ART UNIT | 2118 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 1/26 (20130101) G06F 1/28 (20130101) G06F 1/266 (20130101) G06F 1/3237 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049140 | Halim et al. |
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| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Nagui Halim (Yorktown Heights, New York); Srinivasan Parthasarathy (Yonkers, New York); Venkata N. Pavuluri (New Rochelle, New York); Daby Mousse Sow (Croton-on-Hudson, New York); Deepak Srinivas Turaga (Elmsford, New York) |
| ABSTRACT | An encoding system for encoding an event time series, the system including an inter-arrival time computing device configured to compute an inter-arrival time between a plurality of input events and computes a sequence of events, a transformation device configured to transform the inter-arrival time between the plurality of input events into discrete time symbols, and a mapping device configured to map the input events and the discrete time symbols using a dictionary to output a time gram. |
| FILED | Friday, August 28, 2015 |
| APPL NO | 14/839730 |
| ART UNIT | 2169 — Data Bases & File Management |
| CURRENT CPC | Electric Digital Data Processing G06F 17/30551 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049295 | G-Michael et al. |
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| FUNDED BY |
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| APPLICANT(S) | Tesfaye G-Michael (Panama City, Florida); Daniel Sternlicht (Panama City, Florida); Bradley Marchand (Santa Rosa Beach, Florida); James Derek Tucker (Elgewood, New Mexico); Timothy M. Marston (Seattle, Washington) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Tesfaye G-Michael (Panama City, Florida); Daniel Sternlicht (Panama City, Florida); Bradley Marchand (Santa Rosa Beach, Florida); James Derek Tucker (Elgewood, New Mexico); Timothy M. Marston (Seattle, Washington) |
| ABSTRACT | Methods and systems detect changes occurring over time between synthetic aperture sonar (SAS) images. A processor performs coarse navigational alignment, fine-scale co-registration and local co-registration between current image data and historical image data. Local co-registration includes obtaining correlation peaks for large neighborhood non-overlapping patches. Relative patch translations are estimated and parameterized into error vectors. Interpolation functions formed from the vectors re-map the current image onto the same grid as the historical image and the complex correlation coefficient between images is calculated. The resulting interferogram is decomposed into surge and sway functions used to define the argument of a phase function, which is multiplied by the current image to remove the effects of surge and sway on the interferogram. Based on the aforementioned computations, a canonical correlation analysis is performed to detect scene changes between the historical and new SAS images. |
| FILED | Friday, August 12, 2016 |
| APPL NO | 15/235251 |
| ART UNIT | 2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00543 (20130101) G06K 9/4671 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0057 (20130101) G06T 2207/30212 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049321 | Nugent |
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| FUNDED BY |
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| APPLICANT(S) | KnowmTech, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | KNOWMTECH, LLC (Santa Fe, New Mexico) |
| INVENTOR(S) | Alex Nugent (Santa Fe, New Mexico) |
| ABSTRACT | A thermodynamic RAM circuit composed of a group of AHaH (Anti-Hebbian and Hebbian) computing circuits that form one or more kT-RAM circuits. The AHaH computing circuits can be configured as an AHaH computing stack. The kTRAM circuit(s) can include one or core kT-Cores, each partitioned into AHaH nodes of any size via time multiplexing. The kT-Core couples readout electrodes together to form a larger combined kT-Core. AHaH Computing is the theoretical space encompassing the capabilities of AHaH nodes. At this level of development, solutions have been found for problems as diverse as classification, prediction, anomaly detection, clustering, feature learning, actuation, combinatorial optimization, and universal logic. |
| FILED | Tuesday, March 31, 2015 |
| APPL NO | 14/674428 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) Original (OR) Class G06N 3/063 (20130101) G06N 99/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049447 | Lloyd et al. |
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| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | H. Lee Moffitt Cancer Center and Research Insititute, Inc. (Tampa, Florida) |
| INVENTOR(S) | Mark Cassidy Cridlin Lloyd (Tampa, Florida); Marilyn Yuanxin Ma Bui (Tampa, Florida); Katarzyna Anna Rejniak (Tampa, Florida); Munish Puri (Tampa, Florida) |
| ABSTRACT | Systems and methods for personalized cancer therapy using analysis of pathology slides to target regions in a single sample that interrogates the feature data of a relatively large number of cells. The disclosure describes pathology case review tools of the future which include analysis, visualization and prediction modeling to provide novel information to the pathologist for the diagnosis of disease. This disclosure further describes a user interface to assist the physicians that make that diagnosis, pathologists. Complex computer learning algorithms will combine and mine these data sets to recommend optimal treatment strategies. A computer interface is provided which allows a pathologist to access those data instantly to make a more informed and accurate diagnosis. |
| FILED | Thursday, November 06, 2014 |
| APPL NO | 15/034683 |
| ART UNIT | 2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/00147 (20130101) G06K 9/4604 (20130101) G06K 9/6267 (20130101) G06K 2209/051 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20081 (20130101) G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049450 | Madabhushi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | Case Western Reserve University (Cleveland, Ohio) |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Angel Alfonso Cruz Roa (Villavincencio, Colombia); Fabio Gonzalez (Bogota, Colombia) |
| ABSTRACT | Methods, apparatus, and other embodiments associated with classifying a region of tissue represented in a digitized whole slide image (WSI) using iterative gradient-based quasi-Monte Carlo (QMC) sampling. One example apparatus includes an image acquisition circuit that acquires a WSI of a region of tissue demonstrating cancerous pathology, an adaptive sampling circuit that selects a subset of tiles from the WSI using an iterative QMC Sobol sequence sampling approach, an invasiveness circuit that determines a probability of a presence of invasive pathology in a member of the subset of tiles, a probability map circuit that generates an invasiveness probability map based on the probability, a probability gradient circuit that generates a gradient image based on the invasiveness probability map, and a classification circuit that classifies the region of tissue based on the probability map. A prognosis or treatment plan may be provided based on the classification of the WSI. |
| FILED | Friday, September 30, 2016 |
| APPL NO | 15/282233 |
| ART UNIT | 2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0041 (20130101) Electric Digital Data Processing G06F 19/321 (20130101) G06F 19/345 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/4604 (20130101) G06K 9/6269 (20130101) G06K 9/6277 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049534 | St. George et al. |
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| FUNDED BY |
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| APPLICANT(S) | Paul St. George (Vadnais Heights, Minnesota); Patrick Vue (Champlin, Minnesota) |
| ASSIGNEE(S) | APG Cash Drawer (Minneapolis, Minnesota) |
| INVENTOR(S) | Paul St. George (Vadnais Heights, Minnesota); Patrick Vue (Champlin, Minnesota) |
| ABSTRACT | Cash drawers having a network interface and a processing unit are disclosed. The network interface connects to a network. The processing unit detects cash drawer events and transmits an indication of the cash drawer events across the network interface. The cash drawer optionally includes a storage component that stores the indication of the cash drawer events. The network interface may be a wired or a wireless interface. The cash drawer may receive electrical power from an external supply or from the network connection. |
| FILED | Monday, January 03, 2011 |
| APPL NO | 12/983493 |
| ART UNIT | 2862 — Printing/Measuring and Testing |
| CURRENT CPC | Registering the Receipt of Cash, Valuables, or Tokens G07G 1/14 (20130101) Original (OR) Class G07G 1/0018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049724 | Agarwal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Amit Agarwal (Hillsboro, Oregon); Steven K. Hsu (Lake Oswego, Oregon); Sri Harsha Choday (Hillsboro, Oregon) |
| ABSTRACT | An apparatus is provided which comprises: a first supply node to provide power supply; a column of memory cells coupled to the first supply node; a diode-connected device having a gate terminal coupled to the first supply node, and a source terminal coupled to second supply node; and a stack of devices coupled to the first supply node, wherein at least one device in the stack is coupled to the second supply node, and wherein the stack of devices is controllable according to an operation mode. |
| FILED | Tuesday, June 07, 2016 |
| APPL NO | 15/176069 |
| ART UNIT | 2824 — Semiconductors/Memory |
| CURRENT CPC | Static Stores G11C 5/14 (20130101) G11C 11/419 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049871 | Lieber et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Korea University (Seoul, North Korea) |
| INVENTOR(S) | Charles M. Lieber (Lexington, Massachusetts); Sun-Kyung Kim (Yong In Si, South Korea); Robert Day (Somerville, Massachusetts); Hong-Gyu Park (Seoul, South Korea); Thomas J. Kempa (Somerville, Massachusetts) |
| ABSTRACT | The present invention generally relates to nanoscale wires, including anisotropic deposition in nanoscale wires. In one set of embodiments, material may be deposited on certain portions of a nanoscale wire, e.g., anisotropically. For example, material may be deposited on a first facet of a crystalline nanoscale wire but not on a second facet. In some cases, additional materials may be deposited thereon, and/or the portions of the nanoscale wire may be removed, e.g., to produce vacant regions within the nanoscale wire, which may contain gas or other species. Other embodiments of the invention may be directed to articles made thereby, devices containing such nanoscale wires, kits involving such nanoscale wires, or the like. |
| FILED | Tuesday, February 04, 2014 |
| APPL NO | 14/766285 |
| ART UNIT | 1763 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/04 (20130101) C30B 25/18 (20130101) C30B 29/06 (20130101) C30B 29/08 (20130101) C30B 29/602 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0262 (20130101) H01L 21/02433 (20130101) H01L 21/02532 (20130101) H01L 21/02603 (20130101) Original (OR) Class H01L 21/30604 (20130101) H01L 29/16 (20130101) H01L 29/0669 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050174 | Shur et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sensor Electronic Technology, Inc. (Columbia, South Carolina) |
| ASSIGNEE(S) | Sensor Electronic Technology, Inc. (Columbia, South Carolina) |
| INVENTOR(S) | Michael Shur (Latham, New York); Maxim S. Shatalov (Columbia, South Carolina); Alexander Dobrinsky (Loudonville, New York); Remigijus Gaska (Columbia, South Carolina); Jinwei Yang (Columbia, South Carolina) |
| ABSTRACT | A device including one or more layers with lateral regions configured to facilitate the transmission of radiation through the layer and lateral regions configured to facilitate current flow through the layer is provided. The layer can comprise a short period superlattice, which includes barriers alternating with wells. In this case, the barriers can include both transparent regions, which are configured to reduce an amount of radiation that is absorbed in the layer, and higher conductive regions, which are configured to keep the voltage drop across the layer within a desired range. |
| FILED | Monday, March 13, 2017 |
| APPL NO | 15/457088 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) Original (OR) Class H01L 33/22 (20130101) H01L 33/0025 (20130101) H01L 33/325 (20130101) H01L 33/405 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/125 (20130101) H01S 5/343 (20130101) H01S 5/3054 (20130101) H01S 5/3063 (20130101) H01S 5/34346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050175 | Jain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sensor Electronic Technology, Inc. (Columbia, South Carolina) |
| ASSIGNEE(S) | Sensor Electronic Technology, Inc. (Columbia, South Carolina) |
| INVENTOR(S) | Rakesh Jain (Columbia, South Carolina); Wenhong Sun (Lexington, South Carolina); Jinwei Yang (Columbia, South Carolina); Maxim S. Shatalov (Columbia, South Carolina); Alexander Dobrinsky (Silver Spring, Maryland); Michael Shur (Latham, New York); Remigijus Gaska (Columbia, South Carolina) |
| ABSTRACT | A device having a layer with a patterned surface for improving the growth of semiconductor layers, such as group III nitride-based semiconductor layers with a high concentration of aluminum, is provided. The patterned surface can include a substantially flat top surface and a plurality of stress reducing regions, such as openings. The substantially flat top surface can have a root mean square roughness less than approximately 0.5 nanometers, and the stress reducing regions can have a characteristic size between approximately 0.1 microns and approximately five microns and a depth of at least 0.2 microns. A layer of group-III nitride material can be grown on the first layer and have a thickness at least twice the characteristic size of the stress reducing regions. |
| FILED | Monday, October 30, 2017 |
| APPL NO | 15/797263 |
| ART UNIT | 2823 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/0243 (20130101) H01L 21/0254 (20130101) H01L 21/0265 (20130101) H01L 21/02458 (20130101) H01L 21/02639 (20130101) H01L 29/518 (20130101) H01L 29/2003 (20130101) H01L 29/7786 (20130101) H01L 33/06 (20130101) Original (OR) Class H01L 33/12 (20130101) H01L 33/22 (20130101) H01L 33/24 (20130101) H01L 33/32 (20130101) H01L 2933/0083 (20130101) H01L 2933/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050338 | O'Loughlin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (Washington, District of Columbia) |
| INVENTOR(S) | James P. O'Loughlin (Placitas, New Mexico) |
| ABSTRACT | Concentric shapes (e.g., discs and rings), are nested and displaced from a central plate. The discs are individually positioned by means of mechanical or electro-mechanical actuators such that the over-all result approximates a spherical surface reflector antenna having an adjustable radius of curvature, with the radii of curvature being equivalent to the focal length of the antenna. Another innovation includes reducing the dimensional positioning of the various discs by a modulo of the wavelength of the operating frequency of the antenna, thus reducing the throw accommodation of the actuators to only one wavelength. Each of the discs and the central plate are designed to have substantially the same area, as a nominal configuration. The accuracy of the approximation is improved as the number of discs is increased; however, very acceptable performance is obtained with as few as ten discs when compared to a perfect spherical surface. |
| FILED | Thursday, May 19, 2016 |
| APPL NO | 15/158889 |
| ART UNIT | 2845 — Electrical Circuits and Systems |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/36 (20130101) Original (OR) Class H01Q 1/1292 (20130101) H01Q 15/141 (20130101) H01Q 19/06 (20130101) H01Q 19/10 (20130101) H01Q 19/12 (20130101) H01Q 19/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050349 | Kroening |
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| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Adam M. Kroening (Atlanta, Georgia) |
| ABSTRACT | A waveguide is provided. The waveguide comprises: a ridged waveguide section having a first end and an opposing second end, wherein the ridged waveguide section comprises an input port at the first end, and wherein the ridged waveguide section comprises at least one ridge formed within the ridged waveguide section extending into the ridged waveguide section along an axis normal to the input port; a rectangular waveguide section coupled to the second end; at least one tapered load element located in a non-ridge region of the ridged waveguide section, wherein the at least one tapered load element comprises a material configured to absorb a first portion of power propagating through the waveguide; and at least one lossy back load element within the rectangular waveguide section, wherein the at least one lossy back load element comprises a material configured to absorb a second portion of the power propagating through the waveguide. |
| FILED | Friday, December 02, 2016 |
| APPL NO | 15/367994 |
| ART UNIT | 2845 — Electrical Circuits and Systems |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 13/0233 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050352 | Flores-Molina et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SPAWAR Systems Center Pacific (San Diego, California) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Carlos Flores-Molina (San Diego, California); Kristopher R. Buchanan (San Diego, California); Timi Adeyemi (San Diego, California) |
| ABSTRACT | A phased array antenna comprising: a center conduit filled with electrolytic fluid; a current probe having a central hole therein, wherein the center conduit is disposed within the central hole; and two electrolytic fluid antennas positioned parallel to the center conduit and fluidically coupled to the electrolytic fluid in the center conduit so as to form a field-goal-shaped phased array antenna such that the current probe feeds the electrolytic fluid antennas through magnetic induction. |
| FILED | Monday, September 18, 2017 |
| APPL NO | 15/707049 |
| ART UNIT | 2845 — Electrical Circuits and Systems |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/286 (20130101) H01Q 3/26 (20130101) H01Q 21/20 (20130101) H01Q 21/062 (20130101) Original (OR) Class H01Q 21/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050475 | Khan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| INVENTOR(S) | Saeed M. Khan (Manhattan, Kansas); Nathan Maresch (New Cambria, Kansas); Justin Kuntz (Abilene, Kansas) |
| ABSTRACT | A wireless power transfer system including a transmitting antenna with a first conductive helix wound about a first helical axis, and a first ground plane positioned adjacent to and angled orthogonally with the first helical axis. The wireless power transfer system additionally includes a receiving antenna with a second conductive helix wound about a second helical axis, and a second ground plane positioned adjacent to and angled orthogonally with the second helical axis. Furthermore, the wireless power transfer system further includes a conductive material connecting the first ground plane to the second ground plane. |
| FILED | Monday, May 19, 2014 |
| APPL NO | 14/891166 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/32 (20130101) H01Q 1/362 (20130101) H01Q 11/08 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 5/005 (20130101) H02J 7/025 (20130101) H02J 17/00 (20130101) H02J 50/12 (20160201) Original (OR) Class H02J 50/40 (20160201) H02J 50/90 (20160201) Transmission H04B 5/0037 (20130101) H04B 5/0093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050602 | Nguyen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Clark T.-C. Nguyen (Oakland, California); Robert A. Schneider (Berkeley, California) |
| ABSTRACT | A tunable Q resonator using a capacitive-piezoelectric transducer provides a flexible top electrode above an AlN resonator. The top electrode can be pulled electrostatically towards the resonator and substrate, forming a frictional contact with either the resonator or the combined resonator-electrode structure to the substrate, allowing for electrical tuning the Q of the resonator. With a sufficient electrostatic bias voltage Vb, the resonator may be completely turned OFF, allowing for an integrated switchable AlN resonator. Such switchable resonator may be integrated into a radio frequency (RF) front end as a digitally selectable band pass filter element, obviating the need for ancillary micromechanical switches in the signal path. The device has been demonstrated with a Q approaching 9,000, together with ON/OFF switchability and electromechanical coupling up to 0.63%. Flexible positioning of the top electrode allows for actively controlling the series resonant frequency of the resonator through changes in capacitive coupling. |
| FILED | Thursday, March 17, 2016 |
| APPL NO | 15/073383 |
| ART UNIT | 2842 — Electrical Circuits and Systems |
| CURRENT CPC | Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/17 (20130101) H03H 9/54 (20130101) H03H 9/58 (20130101) H03H 9/467 (20130101) Original (OR) Class H03H 9/505 (20130101) H03H 9/02259 (20130101) H03H 9/02409 (20130101) H03H 9/02425 (20130101) H03H 9/2436 (20130101) H03H 2009/02503 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050696 | Sarabandi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Kamal Sarabandi (Ann Arbor, Michigan); Mani Kashanianfard (Ann Arbor, Michigan) |
| ABSTRACT | A directional repeater system is presented with a simple architecture composed of wideband receive and transmit antennas, a high gain low-power amplifier and a bandpass filter suitable for use in the 2450 MHz ISM band. Close to 70 dB of isolation between transmit and receive antennas over the entire band is achieved for a compact structure. The isolation between the transmit and receive antennas is achieved using polarization mismatch between orthogonal double-stack patch antennas and a two-element receive antenna whose elements are appropriately located with respect to the edge of the substrate ground plane and the transmit antenna to cancel the signal leakage from the transmit antenna to the individual receive antennas. A major advantage of this invention is that the entire bandwidth can be used going through a chain of repeaters whereas for conventional repeaters the available bandwidth is halved for every repeater in the chain. |
| FILED | Wednesday, November 30, 2016 |
| APPL NO | 15/365000 |
| ART UNIT | 2648 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Transmission H04B 7/155 (20130101) Original (OR) Class Climate Change Mitigation Technologies in Information and Communication Technologies [ICT] i.e Information and Communication Technologies Aiming at the Reduction of Their Own Energy Use Y02D 70/12 (20180101) Y02D 70/122 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050720 | Dailey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vencore Labs, Inc. (Basking Ridge, New Jersey) |
| ASSIGNEE(S) | Vencore Labs, Inc. (Basking Ridge, New Jersey) |
| INVENTOR(S) | James Dailey (Basking Ridge, New Jersey); Anjali Agarwal (Basking Ridge, New Jersey); Paul Toliver (Basking Ridge, New Jersey); Colin McKinstrie (Basking Ridge, New Jersey); Nicholas Peters (Knoxville, Tennessee) |
| ABSTRACT | Devices and methods for converting an input electromagnetic signal to an output optical signal consisting of dual sidebands with equalized quantum-limited noise figures of about 3 dB are provided. For instance, a device includes an input for receiving the input electromagnetic signal and an output for delivering the output optical signal; and a non-linear material component connected between the input and the output of the device, the non-linear material component having a non-linear electric susceptibility, wherein the non-linear electric susceptibility of the non-linear material component is selected to mix the input signal with an optical pump signal to produce the output optical signal, wherein the output optical signal has sidebands corresponding to the input signal, and amplifying this optical signal in a phase-sensitive amplifier to produce an output optical signal with sidebands having equalized amplitudes and noise figures. |
| FILED | Friday, May 27, 2016 |
| APPL NO | 15/166857 |
| ART UNIT | 2637 — Optical Communications |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/39 (20130101) G02F 1/3534 (20130101) G02F 1/3544 (20130101) Transmission H04B 10/70 (20130101) H04B 10/80 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050731 | Martin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Bryan J. Martin (Pacific Grove, California); Murali Tummala (Monterey, California); John C. McEachen (Carmel, California) |
| ABSTRACT | The disclosure provides an apparatus and method for the detection of multi-homed hosts on a computer network utilizing a network comprising a plurality of host computers and a central host. Each host computer has one or more network interfaces and transmits TCP packets over the network to the other hosts and the central host. The central host monitors exchanged traffic and sorts received timestamped TCP packets by source address, and utilizes the sorted packets to determine a clock skew associated with each source address. Generally the host computer conducts this process over multiple iterations and provides a representative clock skew, with the representative clock skew typically bounded by a confidence interval determined through probability distribution fitting. The apparatus and method compares the representative clock skews to determine similarity and identify potentially multi-homed hosts. |
| FILED | Friday, January 27, 2017 |
| APPL NO | 15/417307 |
| ART UNIT | 2465 — Multiplex and VoIP |
| CURRENT CPC | Multiplex Communication H04J 3/0661 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 45/72 (20130101) H04L 45/745 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050866 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Yuan-Chi Chang (Armonk, New York); Mustafa Canim (Ossining, New York) |
| ABSTRACT | A method for searching the top-K simple shortest paths between a specified source node and a specified target node in a graph, with graph data partitioned and distributed across a plurality of computing servers, the method including a parallel path search initialized from either one or both of the source and target nodes and traversing the graph by building likely path sequences for a match. Each computing server determines and forwards a path sequence as discovery progresses until the top-K paths are discovered. |
| FILED | Thursday, December 03, 2015 |
| APPL NO | 14/958627 |
| ART UNIT | 2449 — Computer Networks |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/02 (20130101) H04L 45/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10051616 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William S. Song (Lexington, Massachusetts); Adam R. Margetts (Westford, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | William S. Song (Lexington, Massachusetts); Adam R. Margetts (Westford, Massachusetts) |
| ABSTRACT | A system and method for decoding an intended transmission includes a user device that receives a downlink transmission containing a user signal intended for the user device and one or more interfering user signals directed to one or more other user devices. The user device obtains power stacking information that includes a power level for each of the user signals contained in the received downlink transmission. A channel is estimated using pilot signals in the downlink transmission. Each interfering user signal contained in the downlink transmission is demodulated and decoded using the power stacking information. The user device removes all interfering user signals from the received downlink transmission to obtain the user signal intended for the user device. |
| FILED | Tuesday, October 07, 2014 |
| APPL NO | 14/508686 |
| ART UNIT | 2414 — Multiplex and VoIP |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0224 (20130101) Wireless Communication Networks H04W 52/346 (20130101) H04W 72/042 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10051735 | Oleson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OLESON CONVERGENT SOLUTIONS LLC (Santa Barbara, California) |
| ASSIGNEE(S) | Oleson Convergent Solutions LLC (Santa Barbara, California) |
| INVENTOR(S) | Jim Oleson (Santa Barbara, California) |
| ABSTRACT | A product and method for packaging high power integrated circuits or infrared emitter arrays for operation through a wide range of temperatures, including cryogenic operation. The present invention addresses key limitations with the prior art, by providing temperature control through direct thermal conduction or active fluid flow and avoiding thermally induced stress on the integrated circuits or emitter arrays. The present invention allows for scaling of emitter arrays up to extremely large formats, which is not viable under the prior art. The present invention eliminates or otherwise reduces risks associated with vaporization of coolant within the heatsink structure. |
| FILED | Monday, October 30, 2017 |
| APPL NO | 15/797233 |
| ART UNIT | 2896 — Electrical Circuits and Systems |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/12 (20130101) H01L 23/473 (20130101) H01L 24/05 (20130101) H01L 24/13 (20130101) H01L 24/16 (20130101) H01L 24/29 (20130101) H01L 24/32 (20130101) H01L 24/81 (20130101) H01L 25/072 (20130101) H01L 2224/131 (20130101) H01L 2224/0401 (20130101) H01L 2224/0557 (20130101) H01L 2224/2919 (20130101) H01L 2224/05552 (20130101) H01L 2224/05568 (20130101) H01L 2224/16225 (20130101) H01L 2224/32225 (20130101) H01L 2224/81193 (20130101) H01L 2924/00014 (20130101) H01L 2924/014 (20130101) H01L 2924/14 (20130101) H01L 2924/157 (20130101) H01L 2924/10253 (20130101) H01L 2924/10272 (20130101) H01L 2924/10329 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US RE46993 | Winnebeck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ROCHESTER INSTITUTE OF TECHNOLOGY (Rochester, New York) |
| ASSIGNEE(S) | Vnomics Corp. (Pittsford, New York) |
| INVENTOR(S) | Jason Winnebeck (Pittsford, New York); Michael G. Thurston (Penfield, New York); Christopher E. Piggott (Pittsford, New York) |
| ABSTRACT | An Asset Health Management system monitors and analyzes the health of a component of an asset. A sensor network, with one or more sensors operably coupled to an asset component, collects sensor data associated with operating characteristics of the asset component. A processing node (a System Health Node) includes one or more modules, i.e., software functions, and one or more configuration files. The processing node processes the sensor data with the one or more modules according to the one or more configuration files and determines health information corresponding to the asset component. The one or more modules receive and transmit input and output data, respectively, via data streams that organize the input and output data, e.g., according to time stamps and that may be cached. The health information may be displayed on user interfaces and/or may be transmitted over an information network to external systems. |
| FILED | Thursday, May 08, 2014 |
| APPL NO | 14/273179 |
| ART UNIT | 3992 — Central Reexamination Unit (Electrical) |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 23/0283 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 10046086 | Guelcher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Scott A. Guelcher (Thompsons Station, Tennessee); Madison McGough (Nashville, Tennessee); Mukesh K. Gupta (Nashville, Tennessee); Craig L. Duvall (Nashville, Tennessee); John Martin (Nashville, Tennessee); Jon Page (Mount Juliet, Tennessee) |
| ABSTRACT | A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. The low-molecular weight thioketal includes 2,2-dimethoxypropane and thioglycolic acid, wherein the thioketal includes at least two hydroxyl terminal groups. The method of forming the biodegradable scaffold includes blending a thioketal with an excess isocyanate, forming a quasi-prepolymer, mixing the thioketal, the quasi-prepolymer, and a ceramic, and then adding a catalyst to form the biodegradable scaffold. The thioketal is a low-molecular weight thioketal having at least two hydroxyl terminal groups. |
| FILED | Tuesday, October 11, 2016 |
| APPL NO | 15/290875 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/425 (20130101) A61L 2400/06 (20130101) A61L 2430/02 (20130101) Acyclic or Carbocyclic Compounds C07C 323/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/771 (20130101) C08G 18/2063 (20130101) C08G 18/3868 (20130101) C08G 2230/00 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046284 | Ferraris et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | John P. Ferraris (Coppell, Texas); Nimanka Panapitiya (Dallas, Texas); Sumudu Wijenayake (Dallas, Texas); Inga H. Musselman (Dallas, Texas); Chamaal Karunaweera (Richardson, Texas); Kenneth J. Balkus, Jr. (The Colony, Texas) |
| ABSTRACT | In some aspects, the present disclosure provides a polymer composition which comprises two polymer molecules and a compatibilizing agent. In some embodiments, the polymer composition is useful for the preparation of membranes used in the separation of two or more gases. In some embodiments, the polymer composition comprises a polyimide polymer and a polybenzimidazole polymer which have been compatibilizing with a small molecule or a metal organic framework. |
| FILED | Friday, March 11, 2016 |
| APPL NO | 15/068314 |
| ART UNIT | 1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 67/0067 (20130101) B01D 67/0079 (20130101) B01D 69/148 (20130101) B01D 71/021 (20130101) B01D 71/028 (20130101) B01D 71/62 (20130101) Original (OR) Class B01D 71/64 (20130101) B01D 2256/10 (20130101) B01D 2256/16 (20130101) B01D 2256/22 (20130101) B01D 2256/245 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/503 (20130101) C01B 2203/0405 (20130101) C01B 2203/0475 (20130101) Compositions of Macromolecular Compounds C08L 79/04 (20130101) C08L 79/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047015 | Pegna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| ASSIGNEE(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| INVENTOR(S) | Joseph Pegna (Saratoga Springs, New York); John L. Schneiter (Cohoes, New York); Kirk L. Williams (Saratoga Springs, New York); Ramkiran Goduguchinta (Clifton Park, New York) |
| ABSTRACT | A method and apparatus for forming a plurality of fibers from (e.g., CVD) precursors, including a reactor adapted to grow a plurality of individual fibers; and a plurality of independently controllable lasers, each laser of the plurality of lasers growing a respective fiber. A high performance fiber (HPF) structure, including a plurality of fibers arranged in the structure; a matrix disposed between the fibers; wherein a multilayer coating is provided along the surfaces of at least some of the fibers with an inner layer region having a sheet-like strength; and an outer layer region, having a particle-like strength, such that any cracks propagating toward the outer layer from the matrix propagate along the outer layer and back into the matrix, thereby preventing the cracks from approaching the fibers. A method of forming an interphase in a ceramic matrix composite material having a plurality of SiC fibers, which maximizes toughness by minimizing fiber to fiber bridging, including arranging a plurality of SiC fibers into a preform; selectively removing (e.g., etching) silicon out of the surface of the fibers resulting in a porous carbon layer on the fibers; and replacing the porous carbon layer with an interphase layer (e.g., Boron Nitride), which coats the fibers to thereby minimize fiber to fiber bridging in the preform. |
| FILED | Friday, January 18, 2013 |
| APPL NO | 14/372085 |
| ART UNIT | 1786 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/956 (20170801) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/76 (20130101) Original (OR) Class C04B 35/565 (20130101) C04B 35/806 (20130101) C04B 35/62865 (20130101) C04B 35/62868 (20130101) C04B 35/62873 (20130101) C04B 2235/616 (20130101) C04B 2235/3409 (20130101) C04B 2235/5244 (20130101) C04B 2235/5264 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/08 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/16 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/249964 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047058 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chao Zhang (Monterey Park, California); Ying-Chu Chen (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Chao Zhang (Monterey Park, California); Ying-Chu Chen (Los Angeles, California) |
| ABSTRACT | A compound of Formula II, is provided. R1, R2 and R3 are independently either hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino or hydroxyl. X is either F, Cl, Br, I or CN. Y is either N or CH. Compositions that include Formula II can be used to inhibit vacuolar H+ ATPase. |
| FILED | Monday, December 19, 2016 |
| APPL NO | 15/384016 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 239/94 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047128 | Judd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | Justin Judd (Houston, Texas); Junghae Suh (Houston, Texas); Jonathan Silberg (Houston, Texas) |
| ABSTRACT | The present invention is a peptide lock that comprises at least one peptide that is genetically encoded into the Adeno-associated virus (AAV) capsid that block biologically active domains on the virus capsid surface. The peptide lock, can be processed by biological enzymes to restore biological behavior of the capsid-displayed domains, thus ‘decoding the lock’ or opening the lock. A method of forming the peptide lock comprises providing at least one peptide, providing an Adeno-associated virus capsid and genetically inserting the at least one peptide into the Adeno-associated virus capsid to block the biologically active domains on the virus capsid surface. |
| FILED | Monday, April 29, 2013 |
| APPL NO | 13/872949 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/33 (20130101) C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2750/14122 (20130101) C12N 2750/14145 (20130101) C12N 2810/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047366 | Boeke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jef D. Boeke (Baltimore, Maryland); Leslie Mitchell (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of chromosome engineering. More specifically, the present invention provides methods and compositions useful for inducibly linearizing circular DNA molecules in vivo in yeast. In one embodiment, a comprises a nucleic acid encoding a selectable marker, wherein the nucleic acid encoding a selectable marker comprises an intron comprising an endonuclease recognition site flanked by telomere seed sequences. |
| FILED | Thursday, March 06, 2014 |
| APPL NO | 14/772832 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/65 (20130101) C12N 15/81 (20130101) Original (OR) Class C12N 15/905 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047392 | Ivankin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | Northeastern University (Boston, Massachusetts) |
| INVENTOR(S) | Andrey Ivankin (Chicago, Illinois); Joseph Larkin (Dorchester, Massachusetts); Robert Henley (Boston, Massachusetts); Meni Wanunu (Boston, Massachusetts) |
| ABSTRACT | Described herein are systems for analysis of biopolymers and complexes containing biopolymers based on optical measurement of ion flux through pores. Also described are methods of using such devices for analysis of biopolymers and complexes containing biopolymers, including methods of determining the nucleotide sequences of polynucleotides. |
| FILED | Monday, February 23, 2015 |
| APPL NO | 15/119859 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 2521/543 (20130101) C12Q 2563/137 (20130101) C12Q 2565/631 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6408 (20130101) G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 33/48721 (20130101) G01N 2021/6439 (20130101) G01N 2021/7786 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047968 | Barooah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Prabir Barooah (Gainesville, Florida); Rahul Subramany (Gainesville, Florida); Siddharth Goyal (Gainesville, Florida) |
| ABSTRACT | A system for controlling at least one heating, ventilation, and/or air conditioning unit to increase efficiency while maintaining comfort. The system comprises at least one computer. The at least one computer is configured to receive an indication of measured occupant load. The at least one computer is further configured to send a control signal to the at least one heating, ventilation, and/or air conditioning unit. The at least one computer may receive the indication of the measured occupant load by receiving from at least one sensor node at least a zone occupant quantity and a zone temperature. The at least one computer may send the control signal to the at least one heating, ventilation, and/or air conditioning unit by sending a signal that controls at least one variable air volume box to set a supply air flow rate and a supply air temperature based on the measured occupant load. |
| FILED | Thursday, December 11, 2014 |
| APPL NO | 15/102895 |
| ART UNIT | 2115 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/006 (20130101) Original (OR) Class F24F 11/30 (20180101) F24F 11/46 (20180101) F24F 11/62 (20180101) F24F 11/64 (20180101) F24F 2110/10 (20180101) F24F 2110/20 (20180101) F24F 2120/10 (20180101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/406 (20130101) G05B 2219/2614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048193 | Cohen et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Adam E. Cohen (Cambridge, Massachusetts); Sabrina R. Leslie (Cambridge, Massachusetts) |
| ABSTRACT | A curved surface is placed tangent to a slide and displaces a sample liquid from the point or line of contact outward. Imaging indicates a region where fluorescence is observed, and the location of the fluorescence indicates the molecular size. The radius of curvature of the lens is known, the distance from the (center) point of contact of the observed fluorescence is measured with a microscope and the distance of the lens surface to the slide's surface can then be calculated. This distance represents the size of the molecule or ensemble of molecules emitting. Similarly, absorbance, etc. could be measured with a light source below the slide. |
| FILED | Thursday, August 11, 2016 |
| APPL NO | 15/234964 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1436 (20130101) Original (OR) Class G01N 2015/144 (20130101) G01N 2015/1493 (20130101) Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/34 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10056 (20130101) G06T 2207/10064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048222 | Agah et al. |
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| FUNDED BY |
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| APPLICANT(S) | Masoud Agah (Blacksburg, Virginia); Shree Narayanan Sreedharan Nair (Hillsboro, Oregon) |
| ASSIGNEE(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| INVENTOR(S) | Masoud Agah (Blacksburg, Virginia); Shree Narayanan Sreedharan Nair (Hillsboro, Oregon) |
| ABSTRACT | The present invention provides an ionization detector having a base having an enclosed chamber. The enclosed chamber has a first end and a second end. The detector also includes a first outlet which is a source of an excitable medium. A second outlet is provided which functions a source of an analyte that is transported by a carrier gas. An ionization source for creating a discharge from said excitable medium is also provided. The collector electrode generates a time dependent current based on its interaction with ionized analytes from which the analyte may be detected. |
| FILED | Friday, October 31, 2014 |
| APPL NO | 14/529760 |
| ART UNIT | 2868 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/68 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048244 | Rodgers et al. |
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| FUNDED BY |
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| APPLICANT(S) | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida) |
| ASSIGNEE(S) | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida) |
| INVENTOR(S) | Ryan P. Rodgers (Tallahassee, Florida); Winston K. Robbins (Brunswick, Maine); Vladislav V. Lobodin (Tallahassee, Florida) |
| ABSTRACT | A method to determine the distribution of non-reactive sulfur compounds and reactive sulfur compounds in petroleum samples by separating non-reactive sulfur compounds from reactive sulfur compounds in a petroleum composition includes the step of contacting the petroleum composition with a Ag-containing cation exchange media. The petroleum composition and the Ag-containing cation exchange media are contacted with a non-reactive sulfur compound solvent capable of eluting the non-reactive sulfur compounds in the presence of the Ag-containing cation exchange media and incapable of eluting the reactive sulfur compounds in the presence of the Ag-containing cation exchange media at the conditions of the exchange. The non-reactive sulfur compounds are eluted from the media with the non-reactive sulfur compound solvent to provide a first fraction. The amount of non-reactive sulfur compounds in the first fraction is then determined. |
| FILED | Thursday, March 13, 2014 |
| APPL NO | 14/776077 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Separation B01D 15/362 (20130101) B01D 15/3828 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 45/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/96 (20130101) G01N 33/287 (20130101) Original (OR) Class G01N 2030/8854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048252 | Linder et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Vincent Linder (Tewksbury, Massachusetts); Samuel K. Sia (New York, New York); George M. Whitesides (Newton, Massachusetts) |
| ABSTRACT | A method and apparatus for delivering one or more fluids. Fluids may be delivered from a common vessel to a chemical, biological or biochemical process. |
| FILED | Friday, May 01, 2015 |
| APPL NO | 14/702278 |
| ART UNIT | 1677 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0293 (20130101) B01L 3/5027 (20130101) B01L 3/502784 (20130101) B01L 2300/0816 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) G01N 33/5304 (20130101) Original (OR) Class G01N 35/08 (20130101) G01N 35/1002 (20130101) G01N 35/1065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048255 | Boyden et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Edward S. Boyden (Chestnut Hill, Massachusetts); Katarzyna P. Adamala (Somerville, Massachusetts); Daniel Alberto Martin-Alarcon (Brookline, Massachusetts) |
| ABSTRACT | A programmable modular protein architecture for RNA binding comprises a set of modules, derived from RNA-binding protein Pumilio, that can be concatenated into chains of varying composition and length. When bound into a chain, each module has a preferred affinity for a specific RNA base. The chains can bind arbitrary RNA sequences with high specificity and fidelity by varying the sequence of modules within the chains. Each module contains at least 6 amino acids, with the amino acids in positions 1 and 5 providing the preferred affinity for the specific base, and the amino acid at position 2 serving as a stacking unit between concatenated modules. The modules may have four canonic forms, each having a preferred affinity for a different base and characterized by the base with which it has affinity, the two amino acids that provide the affinity, and the amino acid that serves as a stacking unit. |
| FILED | Wednesday, January 13, 2016 |
| APPL NO | 14/995169 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 14/47 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048289 | Lal et al. |
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| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Amit Lal (Ithaca, New York); Kwame Amponsah (Ithaca, New York) |
| ABSTRACT | A multi-tip nano-probe apparatus and a method for probing a sample while using the multi-tip nano-probe apparatus each employ located over a substrate: (1) an immovable probe tip with respect to the substrate; (2) a movable probe tip with respect to the substrate; and (3) a motion sensor that is coupled with the movable probe tip. The multi-tip nano-probe apparatus and related method provide for improved sample probing due to close coupling of the motion sensor with the movable probe tip, and also retractability of the movable probe tip with respect to the immovable probe tip. |
| FILED | Monday, December 17, 2012 |
| APPL NO | 14/364745 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 10/00 (20130101) G01Q 20/00 (20130101) Original (OR) Class G01Q 60/30 (20130101) G01Q 70/06 (20130101) G01Q 70/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048823 | Colgate et al. |
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| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| INVENTOR(S) | James Edward Colgate (Evanston, Illinois); Michael A. Peshkin (Evanston, Illinois); John Glassmire (Seattle, Washington); Laura Winfield Alexander (Sunbury, Ohio) |
| ABSTRACT | A method of imitating a texture on a touch surface, the method including the steps of sensing a position of a user's finger on the touch surface, modulating a coefficient of friction of the touch surface in response to the sensed position of a user's appendage relative to the touch surface and/or a derivative thereof, where the friction modulator does not alter the contour of the touch surface in a manner that is perceptible to a user's sight or touch. |
| FILED | Thursday, July 20, 2017 |
| APPL NO | 15/655602 |
| ART UNIT | 2696 — Selective Visual Display Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 3/016 (20130101) G06F 3/041 (20130101) G06F 3/045 (20130101) Original (OR) Class G06F 3/0362 (20130101) G06F 3/0414 (20130101) G06F 3/0421 (20130101) G06F 2203/04104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050189 | Mehta et al. |
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| FUNDED BY |
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| APPLICANT(S) | ThermoAura Inc. (Albany, New York) |
| ASSIGNEE(S) | ThermoAura Inc. (Albany, New York) |
| INVENTOR(S) | Rutvik J. Mehta (Colonie, New York); Douglas Y. Desario (Albany, New York); Alexander O'Toole (Troy, New York) |
| ABSTRACT | A first aspect of the disclosure provides for method of synthesizing bismuth-antimony seleno-telluride thermoelectric nanocrystals. The method may comprise: synthesizing an oxidative chalcogen precursor, the synthesizing including: dissolving a metal in acidic deionized water by reacting the metal with a caustic solution in the deionized water to synthesize a first solution, and adjusting at least one of: pH level or a pE level of the first solution; exposing the oxidative chalcogen precursor to a pnictogen precursor to create nanoseeds; and subjecting the nanoseeds to a microwave thereby synthesizing the bismuth-antimony seleno-telluride thermoelectric nanocrystals. |
| FILED | Thursday, October 27, 2016 |
| APPL NO | 15/335736 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/32 (20130101) C01P 2006/40 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/16 (20130101) H01L 35/18 (20130101) H01L 35/26 (20130101) Original (OR) Class H01L 35/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050693 | Bejarano et al. |
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| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Oscar Bejarano (Cleveland, Ohio); Sadia Quadri (Sugarland, Texas); Edward W. Knightly (Houston, Texas); Omer Gurewitz (Beer Sheva, Israel); Eugenio Magistretti (Cambridge, Massachusetts) |
| ABSTRACT | A method for transmitting packets. The method includes making a first determination, using a first relevant sample set for a first client device, that the first client device does not need to be sounded and making a second determination, using a second relevant sample set for the second client device, that a second client device needs to be sounded. The method further includes, based on the first and second determination, performing a sounding operation for the second client device to obtain channel state information for the second client device and after performing the sounding operation for the second client device: wirelessly transmitting at least one packet to the first client device using historical channel state information for the first client device, and wirelessly transmitting at least one packet to the second client device using the channel state information. |
| FILED | Thursday, June 30, 2016 |
| APPL NO | 15/199148 |
| ART UNIT | 2466 — Multiplex and VoIP |
| CURRENT CPC | Transmission H04B 7/0626 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0048 (20130101) Wireless Communication Networks H04W 16/28 (20130101) H04W 24/08 (20130101) H04W 48/20 (20130101) H04W 84/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050740 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Lei Zhang (Lexington, Massachusetts); Vincent W. S. Chan (Lincoln, Massachusetts) |
| ABSTRACT | A single-wavelength light path is selected between a source access node and a destination access node of a wavelength-division multiplexed optical network, including selecting an illuminated wavelength of the light path and selecting a start time and duration for a data transfer that would not interfere with other data transfers. If no start time/wavelength combination is available with duration sufficient to transport the data, an additional wavelength is automatically selected, based on modeling, that would not impair traffic being carried by other wavelengths in the network, and without a time-consuming manual process of the prior art. The scheduling process may include selecting a set of optical fibers, a wavelength, a start time and an end time to transport proposed traffic. A novel scheduler avoids checking every possible start time, thereby saving significant processing time. The scheduler schedules single-wavelength light paths, rather than relying on complex wavelength shifting schemes. |
| FILED | Thursday, June 02, 2016 |
| APPL NO | 15/572936 |
| ART UNIT | 2636 — Optical Communications |
| CURRENT CPC | Multiplex Communication H04J 14/0212 (20130101) H04J 14/0257 (20130101) H04J 14/0271 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10051663 | Biswas et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Subir K. Biswas (Okemos, Michigan); Dezhi Feng (East Lansing, Michigan); Faezeh Hajiaghajani Memar (East Lansing, Michigan); Saptarshi Das (East Lansing, Michigan) |
| ABSTRACT | A method and device for transmitting data between wireless devices includes: generating and transmitting, by a first device, a data cluster signal having a signal identifier, a completion marker, and at least one silence interval provided between the signal identifier and the completion marker; receiving, by a second device, the data cluster signal; identifying, by the second device, a signal type and a transmission completion of the signal received; and decoding, by the second device, the silence interval into the data based on the signal type and a duration of the silence interval. |
| FILED | Tuesday, December 13, 2016 |
| APPL NO | 15/377195 |
| ART UNIT | 2473 — Multiplex and VoIP |
| CURRENT CPC | Wireless Communication Networks H04W 4/008 (20130101) H04W 4/80 (20180201) H04W 52/0225 (20130101) H04W 52/0235 (20130101) H04W 74/0816 (20130101) Original (OR) Class H04W 84/12 (20130101) H04W 84/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 10045499 | Bhattacharyya et al. |
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| FUNDED BY |
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| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa) |
| ASSIGNEE(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| INVENTOR(S) | Madan K. Bhattacharyya (Ames, Iowa); Rishi Sumit (Des Moines, Iowa); Binod B. Sahu (Odisha, India) |
| ABSTRACT | The present invention relates to a method of increasing resistance against plant pathogens, particularly Phytophthora and Fusarium virguliforme in transgenic plants and/or plant cells, through the use of non host resistance nucleic acid molecules isolated from Arabidopsis. In these plants, at least one nonhost Arabidopsis resistance protein is introduced in comparison to the wild-type plants to confer resistance to plant pathogens. The invention relates to transgenic plants and/or plant cells having an increased resistance against plant pathogens particularly Phytophthora and Fusarium virguliforme to expression vectors, transformed plants and plant cells as well as the use of such plants in a plant breeding program. |
| FILED | Monday, March 04, 2013 |
| APPL NO | 13/783682 |
| ART UNIT | 1662 — Plants |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/10 (20130101) Original (OR) Class Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046284 | Ferraris et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | John P. Ferraris (Coppell, Texas); Nimanka Panapitiya (Dallas, Texas); Sumudu Wijenayake (Dallas, Texas); Inga H. Musselman (Dallas, Texas); Chamaal Karunaweera (Richardson, Texas); Kenneth J. Balkus, Jr. (The Colony, Texas) |
| ABSTRACT | In some aspects, the present disclosure provides a polymer composition which comprises two polymer molecules and a compatibilizing agent. In some embodiments, the polymer composition is useful for the preparation of membranes used in the separation of two or more gases. In some embodiments, the polymer composition comprises a polyimide polymer and a polybenzimidazole polymer which have been compatibilizing with a small molecule or a metal organic framework. |
| FILED | Friday, March 11, 2016 |
| APPL NO | 15/068314 |
| ART UNIT | 1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 67/0067 (20130101) B01D 67/0079 (20130101) B01D 69/148 (20130101) B01D 71/021 (20130101) B01D 71/028 (20130101) B01D 71/62 (20130101) Original (OR) Class B01D 71/64 (20130101) B01D 2256/10 (20130101) B01D 2256/16 (20130101) B01D 2256/22 (20130101) B01D 2256/245 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/503 (20130101) C01B 2203/0405 (20130101) C01B 2203/0475 (20130101) Compositions of Macromolecular Compounds C08L 79/04 (20130101) C08L 79/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10046995 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aditya Kumar (Niskayuna, New York); Anthony John Murray (Niskayuna, New York); Ruijie Shi (Niskayuna, New York); Zhaoyang Wan (Trevose, Pennsylvania); Mustafa Tekin Dokucu (Niskayuna, New York); Vijaysai Prasad (Kamataka, India) |
| ASSIGNEE(S) | General Electric Company (Schenectady, New York) |
| INVENTOR(S) | Aditya Kumar (Niskayuna, New York); Anthony John Murray (Niskayuna, New York); Ruijie Shi (Niskayuna, New York); Zhaoyang Wan (Trevose, Pennsylvania); Mustafa Tekin Dokucu (Niskayuna, New York); Vijaysai Prasad (Kamataka, India) |
| ABSTRACT | A method of operating a waste water treatment plant (WWTP) having at least one of an aerobic digester (AD) and a membrane bioreactor (MBR) is described. The method of operating AD is comprised of monitoring and controlling AD in real-time using an online extended Kalman filter (EKF) having a online dynamic model of AD. The EKF uses real-time AD measured data, and online dynamic model of AD to update adapted model parameters and estimate model based inferred variables for AD, which are used for AD control by AD control system having supervisory and low-level control layers. The method of operating MBR is similar to that of AD. The supervisory control ensures the WWTP satisfying the effluent quality requirement while minimize the operation cost. A WWTP having at least one of AD or MBR is disclosed. The method of operating a WWTP can be implemented using a computer. |
| FILED | Wednesday, July 25, 2012 |
| APPL NO | 14/234955 |
| ART UNIT | 1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/66 (20130101) C02F 3/006 (20130101) Original (OR) Class C02F 3/28 (20130101) C02F 3/30 (20130101) C02F 3/286 (20130101) C02F 3/1268 (20130101) C02F 3/2853 (20130101) C02F 2209/001 (20130101) C02F 2209/02 (20130101) C02F 2209/04 (20130101) C02F 2209/006 (20130101) C02F 2209/06 (20130101) C02F 2209/07 (20130101) C02F 2209/08 (20130101) C02F 2209/10 (20130101) C02F 2209/14 (20130101) C02F 2209/15 (20130101) C02F 2209/20 (20130101) C02F 2209/22 (20130101) C02F 2209/36 (20130101) C02F 2209/38 (20130101) C02F 2209/40 (20130101) C02F 2209/42 (20130101) C02F 2305/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/1826 (20130101) G01N 33/1866 (20130101) Technologies for Adaptation to Climate Change Y02A 20/206 (20180101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/343 (20130101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 10/15 (20150501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047113 | Wilkerson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin); Board of Trustees of Michigan State University (East Lansing, Michigan); The University of British Columbia (Vancouver, Canada) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); The University of British Columbia (Vancouver, Canada); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Curtis Wilkerson (Swartz Creek, Michigan); John Ralph (Madison, Wisconsin); Saunia Withers (Durham, North Carolina); Shawn D. Mansfield (Vancouver, Canada) |
| ABSTRACT | The invention relates to nucleic acids encoding a feruloyl-CoA:monolignol transferase and the feruloyl-CoA:monolignol transferase enzyme that enables incorporation of monolignol ferulates, for example, including p-coumaryl ferulate, coniferyl ferulate, and sinapyl ferulate, into the lignin of plants. |
| FILED | Monday, August 15, 2016 |
| APPL NO | 15/237331 |
| ART UNIT | 1662 — Plants |
| CURRENT CPC | Compounds of Unknown Constitution C07G 1/00 (20130101) Original (OR) Class Derivatives of Natural Macromolecular Compounds C08H 6/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1029 (20130101) C12N 15/8255 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) Enzymes C12Y 203/01133 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047263 | Abhari |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REG SYNTHETIC FUELS, LLC (Ames, Iowa) |
| ASSIGNEE(S) | REG SYNTHETIC FUELS, LLC (Ames, Iowa) |
| INVENTOR(S) | Ramin Abhari (Bixby, Oklahoma) |
| ABSTRACT | The present invention generally relates to a method for manufacturing phase change material (PCM) pellets. The method includes providing a melt composition, including paraffin and a polymer. The paraffin has a melt point of between about 10° C. and about 50° C., and more preferably between about 18° C. and about 28° C. In one embodiment, the melt composition includes various additives, such as a flame retardant. The method further includes forming the melt composition into PCM pellets. The method further may include the step of cooling the melt to increase the melt viscosity before pelletizing. Further, PCM compounds are provided having an organic PCM and a polymer. Methods are provided to convert the PCM compounds into various form-stable PCMs. A method of coating the PCMs is included to provide PCMs with substantially no paraffin seepage and with ignition resistance properties. |
| FILED | Monday, April 11, 2016 |
| APPL NO | 15/095302 |
| ART UNIT | 1761 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 9/12 (20130101) B29B 9/065 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/005 (20130101) C08J 2323/06 (20130101) C08J 2491/06 (20130101) Compositions of Macromolecular Compounds C08L 23/04 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/063 (20130101) C09K 5/066 (20130101) Original (OR) Class Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 5/0035 (20130101) F24F 2203/10 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 19/02 (20130101) F28D 19/042 (20130101) F28D 20/023 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047446 | Kaczur et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dioxide Materials, Inc. (Boca Raton, Florida) |
| ASSIGNEE(S) | Dioxide Materials, Inc. (Boca Raton, Florida) |
| INVENTOR(S) | Jerry J. Kaczur (North Miami Beach, Florida); Hongzhou Yang (Boca Raton, Florida); Syed Dawar Sajjad (Boca Raton, Florida); Richard I. Masel (Boca Raton, Florida) |
| ABSTRACT | An electrochemical device converts carbon dioxide to a formic acid reaction product. The device includes an anode and a cathode, each comprising a quantity of catalyst. The anode and cathode each have reactant introduced thereto. Two membranes, a cation exchange polymer electrolyte membrane and an anion exchange polymer electrolyte membrane, are interposed between the anode and the cathode, forming a central flow compartment where a carbon dioxide reduction product, such as formic acid, can be recovered. At least a portion of the cathode catalyst is directly exposed to gaseous carbon dioxide during electrolysis. The average current density at the membrane is at least 20 mA/cm2, measured as the area of the cathode gas diffusion layer that is covered by catalyst, and formate ion selectivity is at least 50% at a cell potential difference of 3.0 V. In some embodiments, at least one polymer electrolyte membrane comprises a polymer in which a constituent monomer is (p-vinylbenzyl)-R, where R is selected from the group consisting of imidazoliums, pyridiniums and phosphoniums. In some embodiments, the polymer electrolyte membrane is a Helper Membrane comprising a polymer containing an imidazolium ligand, a pyridinium ligand, or a phosphonium ligand. |
| FILED | Thursday, September 08, 2016 |
| APPL NO | 15/260213 |
| ART UNIT | 1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/14 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/00 (20130101) C25B 1/02 (20130101) C25B 1/04 (20130101) C25B 3/04 (20130101) Original (OR) Class C25B 9/08 (20130101) C25B 9/10 (20130101) C25B 13/08 (20130101) C25B 15/02 (20130101) C25B 15/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8668 (20130101) H01M 8/1023 (20130101) H01M 8/1053 (20130101) H01M 2300/0082 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/366 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/56 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047692 | Roth et al. |
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| FUNDED BY |
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| APPLICANT(S) | DELPHI TECHNOLOGIES IP LIMITED (St. Michael, Barbados) |
| ASSIGNEE(S) | DELPHI TECHNOLOGIES IP LIMITED (, Barbados) |
| INVENTOR(S) | Gregory T. Roth (Davison, Michigan); Gary C. Fulks (Fort Myers, Florida); Andrew Fedewa (Clarkston, Michigan) |
| ABSTRACT | A GDCI engine control system determines if in-cylinder conditions are sufficient to achieve combustion in a given cylinder or if a misfire is likely. Fuel is delivered to that cylinder if combustion is probable, but fuel is disabled to that cylinder if a misfire is probable. |
| FILED | Friday, December 04, 2015 |
| APPL NO | 14/958976 |
| ART UNIT | 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Controlling Combustion Engines F02D 35/023 (20130101) F02D 35/025 (20130101) F02D 35/027 (20130101) F02D 35/028 (20130101) F02D 41/0087 (20130101) F02D 41/1402 (20130101) Original (OR) Class F02D 2041/1409 (20130101) F02D 2041/1412 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 15/08 (20130101) G01M 15/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047863 | Baxter et al. |
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| FUNDED BY |
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| APPLICANT(S) | Larry Baxter (Orem, Utah); Nathan Davis (Bountiful, Utah); Aaron Sayre (Spanish Fork, Utah); David Frankman (Provo, Utah); Kyler Stitt (Lindon, Utah); Skyler Chamberlain (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larry Baxter (Orem, Utah); Nathan Davis (Bountiful, Utah); Aaron Sayre (Spanish Fork, Utah); David Frankman (Provo, Utah); Kyler Stitt (Lindon, Utah); Skyler Chamberlain (Provo, Utah) |
| ABSTRACT | A device is disclosed comprising a diaphragm mechanism. A diaphragm mechanism comprises an enclosure defined by opposing flexible walls joined along a perimeter of the enclosure and one or more coiled springs contained entirely between the opposed flexible walls. A central, helical axis of the one or more coiled springs is disposed substantially parallel to the opposed flexible walls and arrayed in concentric spirals around a central hole or arrayed in parallel bands. |
| FILED | Wednesday, May 24, 2017 |
| APPL NO | 15/603710 |
| ART UNIT | 3753 — Fluid Handling and Dispensing |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 43/026 (20130101) Pistons; Cylinders; Sealings F16J 3/02 (20130101) Original (OR) Class Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 7/123 (20130101) F16K 31/00 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 9/0044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048236 | Van Berkel |
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| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Gary J. Van Berkel (Oak Ridge, Tennessee) |
| ABSTRACT | A system for sampling a sample material includes a probe which can have an outer probe housing with an open end. A liquid supply conduit within the housing has an outlet positioned to deliver liquid to the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust conduit within the housing is provided for removing liquid from the open end of the housing. A liquid exhaust system can be provided for removing liquid from the liquid exhaust conduit at a second volumetric flow rate. A droplet dispenser can dispense drops of a sample or a sample-containing solvent into the open end of the housing. A sensor and a processor can be provided to monitor and maintain a liquid dome present at the open end. |
| FILED | Tuesday, December 12, 2017 |
| APPL NO | 15/839453 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/443 (20130101) A61B 10/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/20 (20130101) G01N 30/7233 (20130101) Original (OR) Class G01N 35/1095 (20130101) G01N 2030/027 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0404 (20130101) H01J 49/0431 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049044 | Boyer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | Michael Boyer (Bellevue, Washington); Gabriel Loh (Bellevue, Washington); Nuwan Jayasena (Sunnyvale, California) |
| ABSTRACT | Proactive flush logic in a computing system is configured to perform a proactive flush operation to flush data from a first memory in a first computing device to a second memory in response to execution of a non-blocking flush instruction. Reactive flush logic in the computing system is configured to, in response to a memory request issued prior to completion of the proactive flush operation, interrupt the proactive flush operation and perform a reactive flush operation to flush requested data from the first memory to the second memory. |
| FILED | Tuesday, June 14, 2016 |
| APPL NO | 15/181415 |
| ART UNIT | 2131 — Selective Visual Display Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0804 (20130101) Original (OR) Class G06F 12/0806 (20130101) G06F 12/0842 (20130101) G06F 2212/69 (20130101) G06F 2212/1016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049848 | Smedley et al. |
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| FUNDED BY |
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| APPLICANT(S) | Brookhaven Science Associates, LLC (Upton, New York); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Brookhaven Science Associates, LLC (Upton, New York); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | John Smedley (Shirley, New York); Klaus Attenkofer (Riverhead, New York); Susanne Schubert (San Mateo, California); Mengjia Gaowei (Port Jefferson Station, New York); John Walsh (Sound Beach, New York) |
| ABSTRACT | Technologies are described for methods for fabricating a film component. The methods may comprise sputtering a first film onto a substrate. The first film may include a semiconductor compound material. The semiconductor compound material may include a semi-metal material and one or more alkali material. The methods may further comprise evaporating a second film onto the first film. The second film may include the one or more alkali materials. The one or more alkali materials may catalyze crystallization of the semiconductor compound material in the first film substantially throughout the first film to form the film component in the first layer. |
| FILED | Friday, June 10, 2016 |
| APPL NO | 15/179091 |
| ART UNIT | 2894 — Semiconductors/Memory |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/14 (20130101) C23C 14/34 (20130101) C23C 14/228 (20130101) C23C 14/5846 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 9/12 (20130101) H01J 9/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050356 | McConkey |
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| FUNDED BY |
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| APPLICANT(S) | Siemens Energy, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | SIEMENS ENERGY, INC. (Orlando, Florida) |
| INVENTOR(S) | Joshua S. McConkey (Orlando, Florida) |
| ABSTRACT | An electrical arrangement (10), including: a first conductor (12) having a first generally planar contact area (34); a second conductor (12) having a second generally planar contact area (40); an intermediate conductor (44) having a first faying area (84) overlying the first contact area and a second faying area (86) overlying the second contact area; a compression arrangement configured to compress the first faying area and the first contact area toward each other and to compress the second faying area and the second contact area toward each other; and a dimpling structure (46) effective to create plural contact points (74) between the first faying area and the first contact area and between the second faying area and the second contact area when the first and the second faying areas and the first and second contact areas are compressed toward each other by the compression arrangement. |
| FILED | Friday, December 19, 2014 |
| APPL NO | 14/576365 |
| ART UNIT | 2847 — Electrical Circuits and Systems |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 4/01 (20130101) H01R 4/021 (20130101) H01R 4/023 (20130101) H01R 4/26 (20130101) H01R 4/34 (20130101) H01R 4/36 (20130101) H01R 4/46 (20130101) H01R 4/245 (20130101) H01R 4/302 (20130101) H01R 4/304 (20130101) Original (OR) Class H01R 4/2437 (20130101) H01R 9/096 (20130101) H01R 12/52 (20130101) H01R 23/722 (20130101) H01R 23/725 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10051719 | Adams et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the Nevada System of Higher Education on behalf of the University of Nevada, Reno (Reno, Nevada) |
| ASSIGNEE(S) | Board of Regents of the Nevada System of Higher Education, on Behalf of the University of Nevada, Reno (Reno, Nevada) |
| INVENTOR(S) | Jesse D. Adams (Reno, Nevada); Grant Korgan (Reno, Nevada); Steven Malekos (Reno, Nevada); Nathalie Renard-Le Galloudec (Livermore, California); Yasuhiko Sentoku (Reno, Nevada); Thomas E. Cowan (Dresden, Germany) |
| ABSTRACT | In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 μm. In particular examples, the distance is less than about 1 μm. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals. |
| FILED | Friday, April 29, 2016 |
| APPL NO | 15/142628 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | X-ray Technique H05G 2/008 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10051720 | Shurter et al. |
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| FUNDED BY |
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| APPLICANT(S) | Los Alamos National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | Los Alamos National Security, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Roger Shurter (Los Alamos, New Mexico); Jose Taccetti (Santa Fe, New Mexico) |
| ABSTRACT | Disclosed below are representative embodiments of methods, apparatus, and systems for generating electrons. For example, certain embodiments comprise a charge gating diamond QED based electron source, which can be suspended within the RF cavity of an electron injection system in a superconducting radiofrequency (SRF) electron accelerator. Embodiments of the disclosed technology are capable of producing low temperature (cold) electron beams, where “temperature” refers to the transverse energy in the extracted electron beam (or beam emittance). Embodiments of the disclosed technology can also exhibit enhanced charge replenishment capabilities by virtue of the material selected to suspend the electron source within the RF cavity of the electron injection system. |
| FILED | Friday, July 08, 2016 |
| APPL NO | 15/205981 |
| ART UNIT | 2844 — Electrical Circuits and Systems |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 10048567 | Papp et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Commerce (Washington, District of Columbia) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Washington, District of Columbia) |
| INVENTOR(S) | Scott Papp (Boulder, Colorado); Scott Diddams (Louisville, Colorado); Katja Beha (Munich, Germany); Daniel Cole (Boulder, Colorado) |
| ABSTRACT | An electronic light synthesizer electronically synthesizes supercontinuum light and includes: a microwave modulator that: receives a continuous wave light including an optical frequency; modulates the continuous wave light at a microwave repetition frequency; and produces a frequency comb modulated at the microwave repetition frequency; a self-phase modulator that: receives the frequency comb; spectrally broadens an optical wavelength range of the frequency comb; and produces broadened light modulated at the microwave repetition frequency; an optical filter that: receives the broadened light from the self-phase modulator; and optically filters electronic noise in the broadened light; and a supercontinuum generator that: receives the broadened light from the optical filter; spectrally broadens the optical wavelength range of the broadened light; and produces supercontinuum light modulated at the microwave repetition frequency. |
| FILED | Monday, March 20, 2017 |
| APPL NO | 15/463643 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/37 (20130101) G02F 1/365 (20130101) G02F 1/3501 (20130101) Original (OR) Class G02F 2001/3507 (20130101) G02F 2001/3528 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049710 | Silva et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary of Commerce (Washington, District of Columbia) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Washington, District of Columbia); UNIVERSITY OF DENVER (Denver, Colorado) |
| INVENTOR(S) | Thomas Silva (Boulder, Colorado); Justin Shaw (Boulder, Colorado); Eric Edwards (Boulder, Colorado); Xin Fan (Highlands Ranch, Colorado); Hans Nembach (Boulder, Colorado) |
| ABSTRACT | A nonvolatile memory cell includes: a first fixed magnetic layer; a first nonmagnetic electrode disposed on the first magnetic layer; a memory storage layer disposed on the first nonmagnetic electrode; a tunnel barrier layer disposed on the memory storage layer; a second fixed magnetic layer disposed on the tunnel barrier layer; and a second nonmagnetic electrode disposed on the second fixed magnetic layer. |
| FILED | Tuesday, September 05, 2017 |
| APPL NO | 15/695173 |
| ART UNIT | 2825 — Semiconductors/Memory |
| CURRENT CPC | Static Stores G11C 11/161 (20130101) Original (OR) Class G11C 11/1673 (20130101) G11C 11/1675 (20130101) G11C 11/1697 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/222 (20130101) H01L 43/02 (20130101) H01L 43/08 (20130101) H01L 43/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050608 | Hati et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Washington, District of Columbia) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Washington, District of Columbia) |
| INVENTOR(S) | Archita Hati (Boulder, Colorado); Craig Nelson (Boulder, Colorado); David Howe (Louisville, Colorado) |
| ABSTRACT | A phase modulation (PM) noise reducer to reduce phase modulation noise of an oscillator, the PM noise reducer including: an amplitude modulation (AM) detector to receive a primary oscillator signal and to produce an AM detector signal based on the primary oscillator signal, the primary oscillator signal including a first phase modulation (PM) noise; a control circuit in electrical communication with the AM detector to receive the AM detector signal and to produce a control signal; a phase shifter in electrical communication with the control circuit to receive the primary oscillator signal and the control signal and to produce a secondary oscillator signal based on the primary oscillator signal and the control signal, the secondary oscillator signal comprising a second PM noise, wherein the second PM noise is less than the first PM noise. |
| FILED | Wednesday, June 22, 2016 |
| APPL NO | 15/189235 |
| ART UNIT | 2842 — Electrical Circuits and Systems |
| CURRENT CPC | Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 2200/009 (20130101) Modulation H03C 1/06 (20130101) H03C 3/02 (20130101) H03C 3/04 (20130101) H03C 5/00 (20130101) Pulse Technique H03K 5/1252 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10050722 | Quinlan et al. |
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| FUNDED BY |
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| APPLICANT(S) | NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY (Gaithersburg, Maryland); Tara Foriter (Boulder, Colorado); Antoine Rolland (Boulder, Colorado); Franklyn Quinlan (Boulder, Colorado) |
| ASSIGNEE(S) | The United States of America, as Represented by the Secretary of Commerce (Washington, District of Columbia) |
| INVENTOR(S) | Franklyn J. Quinlan (Longmont, Colorado); Scott Diddams (Louisville, Colorado); Tara Fortier (Boulder, Colorado); Antoine Rolland (Boulder, Colorado) |
| ABSTRACT | A signal generator includes an optical pulse source to provide a plurality of optical pulses; a photosensitive element configured to receive optical pulses and to produce an electrical signal from optical pulses 6, electrical signal 10 including a spectrum that includes a plurality of discrete frequencies that occur at a repetition rate corresponding to that of the optical pulses or a harmonic thereof; a frequency selector to receive the electrical signal from the photosensitive element, to select dynamically the harmonic from the electrical signal and to communicate the dynamically selected harmonic; a direct digital synthesizer (DDS) to receive the harmonic of the electrical signal from the frequency selector and to produce a first output; and a frequency converter to receive the harmonic from the frequency selector and the first output from the DDS, wherein the frequency converter shifts a frequency of the harmonic by an amount substantially equal to a frequency of the first output from the DDS to produce a second output. |
| FILED | Wednesday, September 30, 2015 |
| APPL NO | 14/872078 |
| ART UNIT | 2637 — Optical Communications |
| CURRENT CPC | Transmission H04B 10/90 (20130101) Original (OR) Class H04B 2210/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 10046820 | Jenett et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The United States of America As Represented By The Administrator Of The National Aeronautics And Space Administration (Washington, District of Columbia) |
| ASSIGNEE(S) | Massachusetts Institute for Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Benjamin Jenett (Cambridge, Massachusetts); Kenneth Cheung (Emerald Hills, California); Neil Gershenfeld (Cambridge, Massachusetts) |
| ABSTRACT | A robotic platform for traversing and manipulating a modular 3D lattice structure is described. The robot is designed specifically for its tasks within a structured environment, and is simplified in terms of its numbers of degrees of freedom (DOF). This allows for simpler controls and a reduction of mass and cost. Designing the robot relative to the environment in which it operates results in a specific type of robot called a “relative robot”. Depending on the task and environment, there can be a number of relative robots. This invention describes a bipedal robot which can locomote across a periodic lattice structure made of building block parts. The robot is able to handle, manipulate, and transport these blocks when there is more than one robot. Based on a general inchworm design, the robot has added functionality while retaining minimal complexity, and can perform numerous maneuvers for increased speed, reach, and placement. |
| FILED | Monday, June 26, 2017 |
| APPL NO | 15/633155 |
| ART UNIT | 3611 — Electrical Circuits and Systems |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/04 (20130101) B25J 9/0009 (20130101) B25J 9/009 (20130101) B25J 9/0096 (20130101) B25J 9/1682 (20130101) B25J 13/006 (20130101) B25J 17/02 (20130101) B25J 18/00 (20130101) Motor Vehicles; Trailers B62D 57/02 (20130101) Original (OR) Class Cosmonautics; Vehicles or Equipment Therefor B64G 4/00 (20130101) B64G 2004/005 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 2219/45083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047015 | Pegna et al. |
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| FUNDED BY |
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| APPLICANT(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| ASSIGNEE(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| INVENTOR(S) | Joseph Pegna (Saratoga Springs, New York); John L. Schneiter (Cohoes, New York); Kirk L. Williams (Saratoga Springs, New York); Ramkiran Goduguchinta (Clifton Park, New York) |
| ABSTRACT | A method and apparatus for forming a plurality of fibers from (e.g., CVD) precursors, including a reactor adapted to grow a plurality of individual fibers; and a plurality of independently controllable lasers, each laser of the plurality of lasers growing a respective fiber. A high performance fiber (HPF) structure, including a plurality of fibers arranged in the structure; a matrix disposed between the fibers; wherein a multilayer coating is provided along the surfaces of at least some of the fibers with an inner layer region having a sheet-like strength; and an outer layer region, having a particle-like strength, such that any cracks propagating toward the outer layer from the matrix propagate along the outer layer and back into the matrix, thereby preventing the cracks from approaching the fibers. A method of forming an interphase in a ceramic matrix composite material having a plurality of SiC fibers, which maximizes toughness by minimizing fiber to fiber bridging, including arranging a plurality of SiC fibers into a preform; selectively removing (e.g., etching) silicon out of the surface of the fibers resulting in a porous carbon layer on the fibers; and replacing the porous carbon layer with an interphase layer (e.g., Boron Nitride), which coats the fibers to thereby minimize fiber to fiber bridging in the preform. |
| FILED | Friday, January 18, 2013 |
| APPL NO | 14/372085 |
| ART UNIT | 1786 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/956 (20170801) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/76 (20130101) Original (OR) Class C04B 35/565 (20130101) C04B 35/806 (20130101) C04B 35/62865 (20130101) C04B 35/62868 (20130101) C04B 35/62873 (20130101) C04B 2235/616 (20130101) C04B 2235/3409 (20130101) C04B 2235/5244 (20130101) C04B 2235/5264 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/08 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/16 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/249964 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048130 | Lambert |
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| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | James L. Lambert (Pasadena, California) |
| ABSTRACT | Methods and systems for Raman spectroscopy and context imaging are disclosed. One or two lasers can be used to excite Raman scattering in a sample, while a plurality of LEDs can illuminate the sample at a different wavelength. The LED light is collected by a lenslet array in order to enable a high depth of field. Focusing of the image can be carried out at specific points of the image by processing the light collected by the lenslet array. |
| FILED | Wednesday, January 06, 2016 |
| APPL NO | 14/989749 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) G01J 3/027 (20130101) G01J 3/44 (20130101) Original (OR) Class G01J 3/108 (20130101) G01J 3/0208 (20130101) G01J 3/0218 (20130101) G01J 3/2823 (20130101) G01J 2003/102 (20130101) G01J 2003/104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049326 | Krasowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America as Represented by the Admin of National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Michael J Krasowski (Chagrin Falls, Ohio); Norman F Prokop (South Euclid, Ohio) |
| ABSTRACT | An apparatus, method, and computer program that can learn a linear or non-linear transfer function are disclosed. In one embodiment, for example, a computer-implemented method may include creating a plurality of combinations for at least one input, and calculating an output for the plurality of combinations. The method may also include calculating an error based on the calculated output. |
| FILED | Friday, February 01, 2013 |
| APPL NO | 13/756604 |
| ART UNIT | 2129 — AI & Simulation/Modeling |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 99/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 10048736 | Eastep et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Jonathan M. Eastep (Portland, Oregon); Richard J. Greco (West Linn, Oregon) |
| ABSTRACT | Methods and apparatus to provide holistic global performance and power management are described. In an embodiment, logic (e.g., coupled to each compute node of a plurality of compute nodes) causes determination of a policy for power and performance management across the plurality of compute nodes. The policy is coordinated across the plurality of compute nodes to manage a job to one or more objective functions, where the job includes a plurality of tasks that are to run concurrently on the plurality of compute nodes. Other embodiments are also disclosed and claimed. |
| FILED | Monday, December 22, 2014 |
| APPL NO | 14/580150 |
| ART UNIT | 2193 — Interprocess Communication and Software Development |
| CURRENT CPC | Electric Digital Data Processing G06F 1/189 (20130101) G06F 1/3203 (20130101) Original (OR) Class G06F 9/4893 (20130101) G06F 9/5094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10048738 | Ardanaz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Federico Ardanaz (Hillsboro, Oregon); Jonathan Eastep (Portland, Oregon); Richard Greco (West Linn, Oregon) |
| ABSTRACT | Apparatus and methods may provide for a central power control unit to grant a power allowance to each of a plurality of computer components and to allocate a shared power pool locally accessible to each of the plurality of computer components when one or more of the plurality of components needs to exceed its granted power allowance. |
| FILED | Thursday, March 03, 2016 |
| APPL NO | 15/060326 |
| ART UNIT | 2118 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 1/26 (20130101) G06F 1/28 (20130101) G06F 1/266 (20130101) G06F 1/3237 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10049140 | Halim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Nagui Halim (Yorktown Heights, New York); Srinivasan Parthasarathy (Yonkers, New York); Venkata N. Pavuluri (New Rochelle, New York); Daby Mousse Sow (Croton-on-Hudson, New York); Deepak Srinivas Turaga (Elmsford, New York) |
| ABSTRACT | An encoding system for encoding an event time series, the system including an inter-arrival time computing device configured to compute an inter-arrival time between a plurality of input events and computes a sequence of events, a transformation device configured to transform the inter-arrival time between the plurality of input events into discrete time symbols, and a mapping device configured to map the input events and the discrete time symbols using a dictionary to output a time gram. |
| FILED | Friday, August 28, 2015 |
| APPL NO | 14/839730 |
| ART UNIT | 2169 — Data Bases & File Management |
| CURRENT CPC | Electric Digital Data Processing G06F 17/30551 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 10047369 | Belknap et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | William R. Belknap (Albany, California); Kent F. McCue (El Cerrito, California); Roger L. Thilmony (El Cerrito, California); Eddie W. Stover (Fort Pierce, Florida); James G. Thomson (El Cerrito, California) |
| ABSTRACT | Expression vectors and expression cassettes containing a tissue specific 5′ transcription regulatory element, optionally linked to a translation regulatory element, optionally linked to an intron transcription regulatory element, operably linked to a heterologous polynucleotide encoding a protein or RNA of interest are described. The 5′ transcription regulatory elements control expression in root tissue cells, phloem tissue cells, or fruit and/or abscission zone tissue cells. These sequences are obtained from citrus plants. Methods of use of these expression vectors and expression cassettes are described, as well as genetically altered plants and parts thereof that contain these expression vectors and/or cassettes. |
| FILED | Friday, December 16, 2016 |
| APPL NO | 15/381442 |
| ART UNIT | 1662 — Plants |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/8225 (20130101) C12N 15/8226 (20130101) C12N 15/8227 (20130101) Original (OR) Class C12N 15/8235 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10047389 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Southern Gardens Citrus (Clewiston, Florida) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Southern Gardens Citrus (Clewiston, Florida) |
| INVENTOR(S) | Wei Zhao (Port St. Lucie, Florida); Elizabeth A Baldwin (Winter Haven, Florida); Jinhe Bai (Port St. Lucie, Florida); Anne Plotto (Winter Haven, Florida); Michael S Irey (Clewiston, Florida) |
| ABSTRACT | A novel method for isolating DNA from juices and ciders is described. This method is low cost and yield large quantities of highly purified DNA even though one uses a small quantity of juice or cider. A method for determining if a juice or cider is safe to consume and/or the quality of the juice or cider are also described. For these methods, one can perform qPCR on the DNA which can be obtained using the disclosed method or any other prior art method, and comparing the amount of DNA from microorganisms is present in the juice and/or cider to determine the safety and/or quality of the juice and/or cider. These methods work even if the liquid was pasteurized. |
| FILED | Monday, September 29, 2014 |
| APPL NO | 14/499508 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6888 (20130101) C12Q 2531/113 (20130101) C12Q 2561/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 10048501 | Gao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Magic Leap, Inc. (Plantation, Florida) |
| ASSIGNEE(S) | Magic Leap, Inc. (Plantation, Florida) |
| INVENTOR(S) | Chunyu Gao (Tucson, Arizona); Yuxiang Lin (Tucson, Arizona); Hong Hua (Tucson, Arizona) |
| ABSTRACT | The present invention comprises a compact optical see-through head-mounted display capable of combining, a see-through image path with a virtual image path such that the opaqueness of the see-through image path can be modulated and the virtual image occludes parts of the see-through image and vice versa. |
| FILED | Wednesday, December 06, 2017 |
| APPL NO | 15/833945 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 13/06 (20130101) G02B 25/001 (20130101) G02B 27/144 (20130101) G02B 27/0172 (20130101) Original (OR) Class G02B 27/283 (20130101) G02B 27/1066 (20130101) G02B 2027/015 (20130101) G02B 2027/0118 (20130101) G02B 2027/0145 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 37/02 (20130101) Image Data Processing or Generation, in General G06T 19/006 (20130101) Pictorial Communication, e.g Television H04N 5/2258 (20130101) H04N 5/23238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10051735 | Oleson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OLESON CONVERGENT SOLUTIONS LLC (Santa Barbara, California) |
| ASSIGNEE(S) | Oleson Convergent Solutions LLC (Santa Barbara, California) |
| INVENTOR(S) | Jim Oleson (Santa Barbara, California) |
| ABSTRACT | A product and method for packaging high power integrated circuits or infrared emitter arrays for operation through a wide range of temperatures, including cryogenic operation. The present invention addresses key limitations with the prior art, by providing temperature control through direct thermal conduction or active fluid flow and avoiding thermally induced stress on the integrated circuits or emitter arrays. The present invention allows for scaling of emitter arrays up to extremely large formats, which is not viable under the prior art. The present invention eliminates or otherwise reduces risks associated with vaporization of coolant within the heatsink structure. |
| FILED | Monday, October 30, 2017 |
| APPL NO | 15/797233 |
| ART UNIT | 2896 — Electrical Circuits and Systems |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/12 (20130101) H01L 23/473 (20130101) H01L 24/05 (20130101) H01L 24/13 (20130101) H01L 24/16 (20130101) H01L 24/29 (20130101) H01L 24/32 (20130101) H01L 24/81 (20130101) H01L 25/072 (20130101) H01L 2224/131 (20130101) H01L 2224/0401 (20130101) H01L 2224/0557 (20130101) H01L 2224/2919 (20130101) H01L 2224/05552 (20130101) H01L 2224/05568 (20130101) H01L 2224/16225 (20130101) H01L 2224/32225 (20130101) H01L 2224/81193 (20130101) H01L 2924/00014 (20130101) H01L 2924/014 (20130101) H01L 2924/14 (20130101) H01L 2924/157 (20130101) H01L 2924/10253 (20130101) H01L 2924/10272 (20130101) H01L 2924/10329 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 10045525 | Husseiny et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TECHNOLOGY INTERNATIONAL INCORPORATED (LaPlace, Louisiana); EMINENT TECHNOLOGY INCORPORATED (Tallahassee, Florida) |
| ASSIGNEE(S) | TECHNOLOGY INTERNATIONAL INCORPORATED (LaPlace, Louisiana); EMINENT TECHNOLOGY INCORPORATED (Tallahassee, Florida) |
| INVENTOR(S) | Abdo A. Husseiny (LaPlace, Louisiana); Omar Abdallah (Woodland Hills, California); F. Bruce Thigpen (Tallahasee, Florida); Ajay Mahajan (North Canton, Ohio); Jonathan Tyron Hagstrum (Menlo Park, California); Zeinab A. Sabri (LaPlace, Louisiana) |
| ABSTRACT | An active non-lethal infrasound system for denying all bird species access to critical areas, particularly in areas around aircraft and other high value systems. The system comprises a plurality of infrasound generators broadcasting continuous infrasonic signals to create a bird-free infrasound active zone within the perimeters of the protected critical area and an infrasound-free dead zones for birds being denied access to the critical areas. Further, an active infrasonic barrier is assembled within an exclusion area surrounding the bird-free infrasound active zone to dampen all low frequency sound waves emanating from the critical area and its perimeters. Wherever the situation allows, a wildlife sanctuary is preferably established further from the exclusion area to attract and protect birds, enforced by broadcasting infrasound signals that simulate natural sounds that attract species typical of the geographic location. |
| FILED | Tuesday, March 04, 2014 |
| APPL NO | 14/197122 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 29/16 (20130101) Original (OR) Class Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 27/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 10046293 | Woodbury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA (Scottsdale, Arizona) |
| INVENTOR(S) | Neal Woodbury (Tempe, Arizona); Stephen Albert Johnston (Tempe, Arizona) |
| ABSTRACT | Provided herein are methods and devices for performing in situ patterned chemistry for synthesizing and preparing peptide arrays. The invention provides a reproducible and scalable platform that can be potentially used to monitor the health of a plurality of individuals. |
| FILED | Thursday, October 17, 2013 |
| APPL NO | 14/436465 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class B01J 2219/00596 (20130101) B01J 2219/00722 (20130101) B01J 2219/00725 (20130101) Peptides C07K 1/047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 10046641 | Penmetsa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Motivo Engineering LLC (Torrance, California) |
| ASSIGNEE(S) | Motivo Engineering LLC (Torrance, California) |
| INVENTOR(S) | Praveen Varma Penmetsa (Long Beach, California); Zachary Meyer Omohundro (Hermosa Beach, California); Damon Christopher Pipenberg (Los Angeles, California) |
| ABSTRACT | A vehicle carries an energy storage system that powers mobility of the vehicle. The vehicle further carries a direct current input coupling to be connected to a direct current (DC) electrical power source, a DC output coupling, an alternating current (AC) input coupling, an AC output coupling, and electronics carried by the vehicle to control both AC and DC voltage and power levels. |
| FILED | Wednesday, March 18, 2015 |
| APPL NO | 14/662132 |
| ART UNIT | 2842 — Electrical Circuits and Systems |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 1/003 (20130101) Original (OR) Class B60L 1/006 (20130101) B60L 1/14 (20130101) B60L 7/14 (20130101) B60L 8/003 (20130101) B60L 11/005 (20130101) B60L 11/007 (20130101) B60L 11/185 (20130101) B60L 11/1818 (20130101) B60L 11/1864 (20130101) B60L 15/007 (20130101) B60L 15/2009 (20130101) B60L 15/2054 (20130101) B60L 2200/40 (20130101) B60L 2210/30 (20130101) B60L 2210/40 (20130101) B60L 2240/12 (20130101) B60L 2240/421 (20130101) B60L 2240/423 (20130101) B60L 2250/12 (20130101) Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 16/03 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/645 (20130101) Y02T 10/7005 (20130101) Y02T 10/7022 (20130101) Y02T 10/7061 (20130101) Y02T 10/7072 (20130101) Y02T 10/7083 (20130101) Y02T 10/7241 (20130101) Y02T 10/7275 (20130101) Y02T 90/14 (20130101) Y02T 90/121 (20130101) Y02T 90/127 (20130101) Y02T 90/128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, August 14, 2018.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2018/fedinvent-patents-20180814.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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