FedInvent™ Patents

Patent Details for Tuesday, February 12, 2019

This page was updated on Monday, March 27, 2023 at 05:44 AM GMT

Department of Health and Human Services (HHS)

10201282 — Genetically encoded infrared fluorescent protease reporters

US 10201282	Shu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Xiaokun Shu (San Francisco, California); Tsz-Leung To (San Francisco, California)
ABSTRACT	The invention described herein features infrared fluorescent protease reporters (iProteases) and methods of use thereof. The iProteases can be used in in vivo and in vitro assays to detect protease activity and disease states associated with protease activity. In a still further embodiment, the present invention provides a kit comprising any of the above described polynucleotides. In a further aspect, the present invention provides a method of in vivo optical imaging. In a still further embodiment, the in vivo imaging is performed in a living animal. In a further aspect, the present invention provides a method of detecting protease activity, the method comprising expressing a polypeptide according to any of those described above in a cell.
FILED	Friday, April 03, 2015
APPL NO	15/301707
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Original (OR) Class A61B 5/4848 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0056 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/503 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Enzymes C12Y 304/2206 (20130101) C12Y 304/22056 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6456 (20130101) G01N 2333/96413 (20130101) G01N 2510/00 (20130101) G01N 2800/52 (20130101)
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10201314 — System and method for evaluation of circulatory function

US 10201314	Frederick et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	Blaise Frederick (Belmont, Massachusetts); Lia Maria Hocke (Medford, Massachusetts); Yunjie Tong (Medford, Massachusetts)
ASSIGNEE(S)	MCLEAN HOSPITAL CORPORATION (Belmont, Massachusetts)
INVENTOR(S)	Blaise Frederick (Belmont, Massachusetts); Lia Maria Hocke (Medford, Massachusetts); Yunjie Tong (Medford, Massachusetts)
ABSTRACT	A system and method for evaluating a circulatory function of an individual includes at least one connection configured to receive signals indicative of functional data relating to at least one functional parameter of the cardiovascular system of the subject and to at least two disparate locations on the subject. A processor is coupled to the at least, one connection and configured to receive the functional data from the at least one connection. The processor is also configured to compare the functional data to identify variations that deviate from an expected delay associated with the disparate locations and provide an assessment of the cardiovascular system function based on the comparison of the functional data.
FILED	Wednesday, April 03, 2013
APPL NO	14/389400
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/021 (20130101) A61B 5/0205 (20130101) A61B 5/0261 (20130101) A61B 5/1455 (20130101) A61B 5/6826 (20130101) A61B 5/7246 (20130101) Original (OR) Class A61B 5/7253 (20130101) A61B 5/7282 (20130101) A61B 5/14546 (20130101) A61B 5/14551 (20130101) A61B 2562/04 (20130101)
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10201500 — Prodrug compositions, prodrug nanoparticles, and methods of use thereof

US 10201500	Lanza et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Washington University (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Gregory M. Lanza (St. Louis, Missouri); Dipanjan Pan (St. Louis, Missouri)
ABSTRACT	The present invention encompasses prodrug compositions, nanoparticles comprising one or more prodrugs, and methods of use thereof.
FILED	Friday, June 10, 2016
APPL NO	15/179626
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/10 (20130101) A61K 9/0019 (20130101) A61K 9/145 (20130101) Original (OR) Class A61K 9/1075 (20130101) A61K 9/1271 (20130101) A61K 31/336 (20130101) A61K 31/337 (20130101) A61K 33/24 (20130101) A61K 41/0071 (20130101) A61K 47/488 (20130101) A61K 47/555 (20170801) A61K 47/4813 (20130101) A61K 47/6907 (20170801) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101)
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10201512 — Autoimmune disorder treatment using RXR agonists

US 10201512	Chandraratna et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH) National Cancer Institute (NCI)
APPLICANT(S)	IO Therapeutics, Inc. (Santa Ana, California); Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S)	IO Therapeutics, Inc. (Santa Ana, California)
INVENTOR(S)	Roshantha A. Chandraratna (San Juan Capistrano, California); Ethan Dmitrovsky (Hanover, New Hampshire); Elizabeth Nowak (West Lebanon, New Hampshire); Randolph Noelle (Plainfield, New Hampshire)
ABSTRACT	The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
FILED	Friday, December 22, 2017
APPL NO	15/852580
ART UNIT	1621 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 31/47 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/201 (20130101) A61K 31/216 (20130101) A61K 31/343 (20130101) A61K 31/353 (20130101) A61K 31/4704 (20130101)
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10201530 — Treatment of BRCA1-defective cancer or resistant cancers

US 10201530	Yen
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	City of Hope (Duarte, California)
ASSIGNEE(S)	City of Hope (Duarte, California)
INVENTOR(S)	Yun Yen (Arcadia, California)
ABSTRACT	Provided herein are methods of treating cancer in a subject by administering COH29 ((N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide)). The methods of treating include treating a BRCA1-defective subject, a PARP1 inhibitor-resistant subject or a DNA-damaging anti-cancer agent resistant subject. The methods include treating cancer by administering COH29 and a DNA-damaging anti-cancer agent in a combined synergistic amount.
FILED	Tuesday, February 20, 2018
APPL NO	15/900677
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/426 (20130101) Original (OR) Class A61K 31/426 (20130101) A61K 31/7068 (20130101) A61K 31/7068 (20130101) A61K 33/24 (20130101) A61K 33/24 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10201538 — Lanthionine synthetase C-like 2-based therapeutics

US 10201538	Bassaganya-Riera et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Small Business Administration (SBA) Small Business Innovation Research (SBIR) Small Business Technology Transfer (STTR)
APPLICANT(S)	Landos Biopharma, Inc. (Blacksburg, Virginia)
ASSIGNEE(S)	LANDOS BIOPHARMA, INC. (Blacksburg, Virginia)
INVENTOR(S)	Josep Bassaganya-Riera (Blacksburg, Virginia); Adria Carbo Barrios (Blacksburg, Virginia); Richard Gandour (Blacksburg, Virginia); Julian D. Cooper (Blacksburg, Virginia); Raquel Hontecillas (Blacksburg, Virginia)
ABSTRACT	Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease.
FILED	Wednesday, June 13, 2018
APPL NO	16/007151
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4439 (20130101) Acyclic or Carbocyclic Compounds C07C 65/40 (20130101) Heterocyclic Compounds C07D 213/69 (20130101) C07D 213/79 (20130101) C07D 307/60 (20130101) C07D 307/68 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101)
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10201539 — Composition for reducing nervous system injury and method of making and use thereof

US 10201539	Xiong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	MOREHOUSE SCHOOL OF MEDICINE (Atlanta, Georgia)
ASSIGNEE(S)	MOREHOUSE SCHOOL OF MEDICINE (Atlanta, Georgia)
INVENTOR(S)	Zhigang Xiong (Atlanta, Georgia); Roger P. Simon (Atlanta, Georgia)
ABSTRACT	This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
FILED	Tuesday, February 28, 2017
APPL NO	15/445833
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/00 (20130101) A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 31/40 (20130101) A61K 31/55 (20130101) A61K 31/155 (20130101) A61K 31/4965 (20130101) Original (OR) Class Peptides C07K 14/43518 (20130101)
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10201575 — Oncolytic HSV vector

US 10201575	Uchida et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Hiroaki Uchida (Tokyo, Japan); Justus B. Cohen (Allison Park, Pennsylvania); Joseph C. Glorioso, III (Pittsburgh, Pennsylvania); Paola Grandi (Pittsburgh, Pennsylvania)
ABSTRACT	The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and a plurality of copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells, and a deletion of the internal repeat (joint) region in the HSV genome comprising one copy of the ICP0, ICP34.5, LAT, and ICP4 genes and the ICP47 promoter. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.
FILED	Tuesday, October 28, 2014
APPL NO	15/032958
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/763 (20130101) Original (OR) Class Peptides C07K 14/005 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16621 (20130101) C12N 2710/16622 (20130101) C12N 2710/16632 (20130101) C12N 2710/16641 (20130101) C12N 2710/16643 (20130101) C12N 2710/16645 (20130101) C12N 2710/16662 (20130101) C12N 2710/16671 (20130101)
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10201589 — Compositions and methods for treating disease using Salmonella T3SS effector protein (SipA)

US 10201589	McCormick et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Beth McCormick (Haverhill, Mississippi); Regino Mercado-Lubo (Worcester, Massachusetts)
ABSTRACT	The invention provides compositions and methods for reducing one or more symptoms of disease by administering compositions comprising SipA. The invention's compositions and methods are particularly advantageous in reducing symptoms of diseases that are associated with overexpression of P-gp and/or p53. The invention's compositions and methods are useful in reducing cancer symptom and/or cancer multidrug resistance (MDR). The invention provides a method for reducing one or more symptoms of cancer in a mammalian subject in need thereof, comprising administering to said subject a composition comprising purified SipA. In one embodiment, said SipA is operably conjugated to a nanoparticle. In another embodiment, said cancer comprises cancer cells resistant to at least one cytotoxin.
FILED	Thursday, December 11, 2014
APPL NO	15/103844
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/164 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/48023 (20130101) A61K 47/48038 (20130101) A61K 47/48246 (20130101) A61K 47/48415 (20130101) A61K 47/48861 (20130101)
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10201591 — TSLP induces neutrophil mediated killing of methicillin-resistant staphylococcus aureus

US 10201591	Leonard et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Warren Jaye Leonard (Bethesda, Maryland); Erin Elizabeth West (Washington Grove, Maryland); Rosanne Spolski (Silver Spring, Maryland); K. Christopher Garcia (Menlo Park, California)
ABSTRACT	The invention provides a method of promoting the host defense of a patient to a bacterial infection comprising administering to a patient suffering or at risk of a bacterial infection, a pharmaceutical composition comprising an effective amount of the pleiotropic cytokine, thymic stromal lymphopoietin (TSLP) protein or polypeptide in an amount and at a location sufficient to promote the host defense of the patient to the bacterial infection. In a preferred embodiment, the bacterial infection is the infection of the patient with MRSA. The invention also provides a method of treating blood product, which comprises introducing a TSLP protein or polypeptide into such blood product, wherein the blood product is extracorporeal and comprises at least one neutrophil.
FILED	Monday, November 07, 2016
APPL NO	15/345213
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 38/19 (20130101) Original (OR) Class
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10201596 — Peptide conjugated particles for the treatment of allergy

US 10201596	Shea et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Lonnie D. Shea (Evanston, Illinois); Stephen D. Miller (Evanston, Illinois); Jonathan Woon Teck Yap (Evanston, Illinois); Daniel R. Getts (Washington, District of Columbia); Derrick McCarthy (Evanston, Illinois)
ABSTRACT	The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
FILED	Friday, June 21, 2013
APPL NO	14/410011
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 9/1647 (20130101) A61K 39/001 (20130101) A61K 39/0005 (20130101) Original (OR) Class A61K 39/0008 (20130101) A61K 39/35 (20130101) A61K 39/385 (20130101) A61K 47/6937 (20170801) A61K 2039/577 (20130101)
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10201601 — Compositions and methods for increasing immunogenicity of glycoprotein vaccines

US 10201601	Galili
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Uri Galili (Shrewsbury, Massachusetts)
ABSTRACT	The present invention relates to the microbial immunogens engineered to bear α-gal epitope(s) for induction of potent humoral and cellular immune responses when administered to subjects having anti-Gal antibodies. In one embodiment, the present invention provides compositions and methods for propagating influenza virus in human, ape, Old World monkey or bird cells that have been engineered to express an α1,3galactosyltransferase (α 1,3GT) gene to produce virions bearing hemagglutinin molecules containing α-gal epitopes, to increase the immunogenicity of the influenza virus. In another embodiment, the present invention provides fusion proteins between influenza virus hemagglutinin and a microbial peptide or protein of interest, and enzymatic processing of this fusion protein to carry α-gal epitopes, to increase the immunogenicity of the microbial peptide or protein of interest.
FILED	Friday, April 21, 2017
APPL NO	15/494017
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 39/385 (20130101) A61K 2039/5252 (20130101) A61K 2039/6031 (20130101) A61K 2039/6087 (20130101) A61K 2039/55566 (20130101) Peptides C07K 14/005 (20130101) C07K 2319/91 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/1051 (20130101) C12N 9/1081 (20130101) C12N 2760/16122 (20130101) C12N 2760/16134 (20130101) C12N 2760/16152 (20130101) C12N 2760/16222 (20130101) C12N 2760/16252 (20130101) Enzymes C12Y 204/01087 (20130101) C12Y 302/01018 (20130101)
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10201613 — Method of creating hydrogels through oxime bond formation

US 10201613	Maynard et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Heather D. Maynard (Los Angeles, California); Tatiana Segura (Los Angeles, California); Gregory Grover (Carlsbad, California); Jonathan Lam (Los Angeles, California)
ABSTRACT	A method of creating a hydrogel, comprising the step of condensing first and second functional groups, wherein the first group comprises a molecule or macromolecule of interest containing two or more hydroxylamine or aminooxy groups and the second group comprises a molecule or macromolecule of interest containing two or more aldehyde/ketone/other reactive oxo groups, under conditions such that a hydrogel forms.
FILED	Tuesday, August 20, 2013
APPL NO	14/426259
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0024 (20130101) A61K 35/545 (20130101) A61K 47/42 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/48 (20130101) C08G 65/337 (20130101) C08G 65/33303 (20130101) C08G 65/33337 (20130101) C08G 2650/30 (20130101) C08G 2650/44 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 3/246 (20130101) C08J 2300/104 (20130101) C08J 2300/106 (20130101) Compositions of Macromolecular Compounds C08L 101/06 (20130101) C08L 101/06 (20130101) C08L 101/06 (20130101) C08L 101/025 (20130101) C08L 101/025 (20130101) C08L 101/025 (20130101) C08L 2203/02 (20130101)
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10201618 — Alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof

US 10201618	Anderson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Daniel Griffith Anderson (Framingham, Massachusetts); Joseph R. Dorkin (Somerville, Massachusetts); Owen Shea Fenton (Somerville, Massachusetts); Kevin John Kauffman (Somerville, Massachusetts); Rebecca L. McClellan (Westwood, Massachusetts)
ABSTRACT	Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of R^Lis independently optionally substituted C₆-C₄₀alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
FILED	Friday, June 17, 2016
APPL NO	15/186361
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1816 (20130101) A61K 47/545 (20170801) A61K 48/0033 (20130101) Original (OR) Class Heterocyclic Compounds C07D 241/08 (20130101)
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10201619 — Regenerating functional neurons for treatment of disease and injury in the nervous system

US 10201619	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Gong Chen (State College, Pennsylvania); Lei Zhang (State College, Pennsylvania); Zheng Wu (State College, Pennsylvania); Yuchen Chen (State College, Pennsylvania); Fan Wang (State College, Pennsylvania); Ziyuan Guo (State College, Pennsylvania)
ABSTRACT	Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.
FILED	Thursday, July 06, 2017
APPL NO	15/643186
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2227/105 (20130101) A01K 2267/0356 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 48/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/13043 (20130101)
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10201621 — Charge-balanced imaging agents

US 10201621	Frangioni et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Georgia State University Research Foundation Inc. (Atlanta, Georgia)
ASSIGNEE(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Georgia State University Research Foundation Inc. (Atlanta, Georgia)
INVENTOR(S)	John V. Frangioni (Wayland, Massachusetts); Maged M. Henary (Lawrenceville, Georgia)
ABSTRACT	The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio.
FILED	Monday, June 26, 2017
APPL NO	15/633233
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) Original (OR) Class Heterocyclic Compounds C07D 209/02 (20130101) C07D 209/42 (20130101) C07D 255/02 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 23/0066 (20130101) C09B 23/086 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101)
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10201622 — Tumour-targeted theranostic

US 10201622	Loadman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Bradford (Yorkshire, United Kingdom); The Trustees of The Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)	The Trustees of The Leland Stanford Junior University (Palo Alto, California); Incanthera Ltd (Manchester, United Kingdom)
INVENTOR(S)	Paul Loadman (Bradford, United Kingdom); Robert Falconer (Bradford, United Kingdom); Jason Gill (Bradford, United Kingdom); Jianghong Rao (Stanford, California); Heike E. Daldrup-Link (Stanford, California)
ABSTRACT	The present inventors have harnessed the targeting of nanoparticles to tumor sites, combined with the tumor site specific elevated MMP-14 activity within one conjugate to simultaneously deliver a vascular disrupting agent (VDA) and a MRI contrast agent to a tumor site. The MMP activatable conjugate of the present invention provides both therapeutic and diagnostic functions—and is referred to as a “theranostic”. The theranostic conjugate of the present invention achieves the benefits of tumor site specificity, VDA delivery and MRI contrast agent delivery in a single theranostic conjugate. Consequently, the present invention provides a cancer “theranostic” which improves therapeutic efficacy while simultaneously reducing dose-limiting systemic toxicities and provides a tool for rapidly and non-invasively identifying tumor location, monitoring drug delivery and pharmacodynamics.
FILED	Friday, July 25, 2014
APPL NO	14/908096
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 47/60 (20170801) A61K 47/65 (20170801) A61K 47/6927 (20170801) A61K 47/6929 (20170801) A61K 49/085 (20130101) A61K 49/186 (20130101) A61K 49/1866 (20130101) Original (OR) Class
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10201634 — Nanotubes and compositions thereof

US 10201634	Webster et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	Brown University (Providence, Rhode Island); National Research Council of Canada (Ottawa, Canada); The Governors of the University of Alberta (Edmonton, Canada)
ASSIGNEE(S)	Brown University (Providence, Rhode Island); National Research Council of Canada (, Canada); The Governors of the University of Alberta (, Canada)
INVENTOR(S)	Thomas J. Webster (Barrington, Rhode Island); Hicham Fenniri (Edmonton, Canada); Usha Devi Hemraz (Edmonton, Canada)
ABSTRACT	The present invention is directed to implants and the modification of the surface of implants using amino acid or polypeptide functionalized rosette nanotubes.
FILED	Monday, June 23, 2014
APPL NO	14/311509
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/22 (20130101) A61L 27/34 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 2400/12 (20130101) A61L 2400/18 (20130101) Heterocyclic Compounds C07D 519/00 (20130101)
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10201697 — Flexible circuit electrode array with wire or film support

US 10201697	Greenberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Second Sight Medical Products, Inc. (Sylmar, California)
ASSIGNEE(S)	Second Sight Medical Products, Inc. (Sylmar, California)
INVENTOR(S)	Robert J Greenberg (Los Angeles, California); Eugene de Juan (San Francisco, California); Mark S Humayun (Glendale, California); Kelly McClure (Simi Valley, California); Neil Hamilton Talbot (La Crescenta, California); Jordan Matthew Neysmith (Mountain View, California); Brian V Mech (Santa Clarita, California); James Singleton Little (Arvada, Colorado); Mohamed Khaldi (Los Angeles, California)
ABSTRACT	The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad on the array.
FILED	Monday, November 27, 2017
APPL NO	15/823459
ART UNIT	3762 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/05 (20130101) A61N 1/0541 (20130101) A61N 1/0543 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/118 (20130101) H05K 1/0393 (20130101)
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10201718 — Method and system for using Cherenkov radiation to monitor beam profiles and radiation therapy

US 10201718	Pogue et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Brian William Pogue (Hanover, New Hampshire); David Joseph Gladstone (Norwich, Vermont); Scott Christian Davis (Woodsville, New Hampshire); Johan Jakob Axelsoon (Lund, Sweden); Adam Kenneth Glaser (Lebanon, New Hampshire); Rongxiao Zhang (Norwich, Vermont)
ASSIGNEE(S)	THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
INVENTOR(S)	Brian William Pogue (Hanover, New Hampshire); David Joseph Gladstone (Norwich, Vermont); Scott Christian Davis (Woodsville, New Hampshire); Johan Jakob Axelsoon (Lund, Sweden); Adam Kenneth Glaser (Lebanon, New Hampshire); Rongxiao Zhang (Norwich, Vermont)
ABSTRACT	A system for providing monitored radiation therapy has a high energy radiation source, apparatus for excluding uncontrolled ambient light, and apparatus for collecting light emitted from a subject. The system has apparatus for spectrally analyzing the collected light, and a processor for determining oxygenation or other metabolic function of tissue within the subject from spectral analysis of the collected light. The system monitors radiation therapy by providing a beam of high energy radiation; collecting Cherenkov and/or photoluminescent light from the subject, the light generated along the beam; spectrally analyzing the light; and determining oxygenation or metabolic function of tissue from the spectral analysis. Beam profile of the system is calibrated by imaging from multiple angles Cherenkov and/or photoluminescent light emitted by a phantom placed in the beam in lieu of a subject, captured images are analyzed to determine beam profile.
FILED	Friday, May 18, 2012
APPL NO	14/118825
ART UNIT	3737 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/1455 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1065 (20130101) Original (OR) Class A61N 5/1075 (20130101) A61N 2005/1076 (20130101) Measurement of Nuclear or X-radiation G01T 1/22 (20130101)
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10202322 — Resorcinol derivatives

US 10202322	McAllister et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Sutter West Bay Hospitals (San Francisco, California)
ASSIGNEE(S)	Sutter Bay Hospitals (San Francisco, California)
INVENTOR(S)	Sean D. McAllister (San Francisco, California); Pierre-Yves Desprez (Richmond, California); Anuradha Mahadevan (Westford, Massachusetts)
ABSTRACT	The disclosure relates to cannabinoid derivative compounds, pharmaceutical compositions made thereof, and methods for treating various diseases and disorders including cancer.
FILED	Wednesday, November 01, 2017
APPL NO	15/800930
ART UNIT	1671 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/05 (20130101) A61K 31/337 (20130101) A61K 31/337 (20130101) A61K 31/352 (20130101) A61K 31/352 (20130101) A61K 31/4188 (20130101) A61K 31/4188 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Acyclic or Carbocyclic Compounds C07C 39/17 (20130101) C07C 39/23 (20130101) C07C 39/42 (20130101) Original (OR) Class C07C 43/21 (20130101) C07C 43/23 (20130101) C07C 69/16 (20130101) C07C 69/017 (20130101) C07C 69/40 (20130101) C07C 271/44 (20130101) C07C 309/17 (20130101) C07C 2601/14 (20170501) C07C 2601/16 (20170501) Heterocyclic Compounds C07D 213/80 (20130101) C07D 295/30 (20130101) C07D 295/096 (20130101) C07D 333/10 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/12 (20130101)
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10202327 — Highly robust efficient catalyst for selective dehydrogenation of neat glycerol to lactic acid

US 10202327	Williams et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
INVENTOR(S)	Travis J. Williams (Los Angeles, California); Zhiyao Lu (Duarte, California); Ivan Demianets (Los Angeles, California)
ABSTRACT	A catalyst system includes a complex having formula I which advantageously has a sterically protecting N-heterocyclic carbene (NHC) carbene-pyridine ligand to handle harsh reactions conditions than many prior art catalysts: wherein M is a transition metal; o is 0, 1, 2, 3, or 4; R₁is a C_1-6alkyl, a C_6-18aryl, or an optionally substituted C_5-18heteroaryl. In a refinement, R₁is methyl, ethyl, butyl, n-propyl, isopropyl, n-butyl, sec-butyl, or t-butyl; R₂, R₃, R₃′ are independently an optionally substituted C_1-6alkyl, halo (e.g., Cl, F, Br, etc), NO₂, an optionally substituted C_6-18aryl, or an optionally substituted C_5-18heteroaryl; R₄, R₄′ are independently an optionally substituted C_1-6alkyl, halo, NO₂, an optionally substituted C_6-18aryl, or an optionally substituted C_5-18heteroaryl; and X⁻ is a negatively charge counter ion and L₁, L₂are each independently a neutral ligand.
FILED	Thursday, February 02, 2017
APPL NO	15/422728
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2295 (20130101) B01J 2231/763 (20130101) B01J 2531/827 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/326 (20130101) C01B 2203/0227 (20130101) C01B 2203/1064 (20130101) C01B 2203/1223 (20130101) Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 7/14 (20130101) Acyclic or Carbocyclic Compounds C07C 51/16 (20130101) C07C 51/16 (20130101) C07C 51/295 (20130101) Original (OR) Class C07C 51/295 (20130101) C07C 59/08 (20130101) C07C 59/08 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0033 (20130101)
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10202340 — Glucosylceramide synthase inhibitors and therapeutic methods using the same

US 10202340	Larsen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Scott D. Larsen (South Lyon, Michigan); Akira Abe (Ann Arbor, Michigan); Liming Shu (Ann Arbor, Michigan); Michael William Wilson (Ann Arbor, Michigan); Richard F. Keep (Ann Arbor, Michigan); Duxin Sun (Ann Arbor, Michigan); James A. Shayman (Ann Arbor, Michigan)
ABSTRACT	Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
FILED	Monday, February 01, 2016
APPL NO	15/546320
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4015 (20130101) Heterocyclic Compounds C07D 205/04 (20130101) C07D 207/04 (20130101) C07D 207/06 (20130101) Original (OR) Class C07D 207/09 (20130101) C07D 207/10 (20130101) C07D 263/20 (20130101) C07D 263/24 (20130101) C07D 295/13 (20130101) C07D 295/125 (20130101)
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10202342 — Targeted delivery of imaging probes for in vivo cellular imaging

US 10202342	Kao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Joseph P. Y. Kao (Silver Spring, Maryland); Scott R. Burks (Baltimore, Maryland); Gerald R. Rosen (Rockville, Maryland)
ASSIGNEE(S)	University of Maryland, Baltimore (Baltimore, Maryland)
INVENTOR(S)	Joseph P. Y. Kao (Silver Spring, Maryland); Scott R. Burks (Baltimore, Maryland); Gerald R. Rosen (Rockville, Maryland)
ABSTRACT	The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching concentrations thereof, wherein the liposomes optionally comprise a targeting ligand specific to and having affinity for targeted tissue.
FILED	Wednesday, December 22, 2010
APPL NO	12/975655
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/0071 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/10 (20130101) A61K 49/20 (20130101) A61K 49/0041 (20130101) A61K 49/0084 (20130101) A61K 49/1812 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 207/46 (20130101) Original (OR) Class C07D 211/94 (20130101) C07D 403/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/574 (20130101) G01N 33/5432 (20130101) G01N 33/54353 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/60 (20130101)
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10202343 — MIF modulators

US 10202343	Jorgensen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)	Yale University (New Haven, Connecticut)
INVENTOR(S)	William L. Jorgensen (Deep River, Connecticut); Richard J. Bucala (Cos Cob, Connecticut)
ABSTRACT	The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression.
FILED	Friday, July 21, 2017
APPL NO	15/656555
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 209/18 (20130101) Original (OR) Class C07D 235/12 (20130101) C07D 235/24 (20130101) C07D 249/06 (20130101) C07D 263/58 (20130101) C07D 275/04 (20130101) C07D 307/80 (20130101) C07D 307/83 (20130101) C07D 401/04 (20130101) C07D 401/06 (20130101) C07D 403/04 (20130101) C07D 405/06 (20130101) C07D 413/04 (20130101) C07D 417/04 (20130101)
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10202350 — MCT4 inhibitors for treating disease

US 10202350	Parnell et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Vettore, LLC (San Francisco, California)
ASSIGNEE(S)	Vettore, LLC (San Francisco, California)
INVENTOR(S)	Kenneth Mark Parnell (Kaysville, Utah); John McCall (Boca Grande, Florida)
ABSTRACT	Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.
FILED	Monday, June 13, 2016
APPL NO	15/180623
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) A61K 31/415 (20130101) A61K 31/427 (20130101) A61K 31/427 (20130101) A61K 31/4155 (20130101) A61K 31/4155 (20130101) A61K 31/4439 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 231/12 (20130101) Original (OR) Class C07D 401/06 (20130101) C07D 405/12 (20130101) C07D 409/04 (20130101) C07D 417/04 (20130101)
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10202367 — Heterocyclic compounds and methods of use thereof

US 10202367	Liang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); University of Kansas (Lawrence, Kansas)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); University of Kansas (Lawrence, Kansas)
INVENTOR(S)	Tsanyang Liang (Potomac, Maryland); Zongyi Hu (Potomac, Maryland); Juan Jose Marugan (Gaithersburg, Maryland); Noel Terrence Southall (Potomac, Maryland); Shanshan He (North Bethesda, Maryland); Xin Hu (Frederick, Maryland); Jingbo Xiao (Rockville, Maryland); Marc Ferrer (Potomac, Maryland); Wei Zheng (Potomac, Maryland); Kevin J. Frankowski (Lawrence, Kansas); Frank J. Schoenen (Lawrence, Kansas); Kelin Li (Lawrence, Kansas)
ABSTRACT	Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R¹, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.
FILED	Friday, June 12, 2015
APPL NO	15/317864
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/4178 (20130101) A61K 31/4545 (20130101) A61K 31/5377 (20130101) A61K 31/7056 (20130101) A61K 31/7068 (20130101) A61K 38/07 (20130101) A61K 38/13 (20130101) A61K 38/212 (20130101) Heterocyclic Compounds C07D 413/06 (20130101) Original (OR) Class C07D 413/14 (20130101) C07D 417/14 (20130101) C07D 471/08 (20130101) Technologies for Adaptation to Climate Change Y02A 50/385 (20180101)
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10202397 — Anti-cancer compounds targeting Ral GTPases and methods of using the same

US 10202397	Theodorescu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate (Denver, Colorado)
ASSIGNEE(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S)	Dan Theodorescu (Englewood, Colorado); Michael Fitzpatrick Wempe (Aurora, Colorado); David Ross (Niwot, Colorado); Chao Yan (Denver, Colorado); Phillip Reigan (Denver, Colorado)
ABSTRACT	Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
FILED	Friday, July 10, 2015
APPL NO	15/324629
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4162 (20130101) A61K 31/4162 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 491/052 (20130101) Original (OR) Class
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10202413 — Neuroactive enantiomeric 15-, 16- and 17-substituted steroids as modulators for GABA type-A receptors

US 10202413	Covey
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Washington University (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Douglas Covey (St. Louis, Missouri)
ABSTRACT	The present disclosure is generally directed to neuroactive enantiomeric 15-, 16- and 17-substituted steroids with additional optional substituents at carbons 3, 4, 6, 7, 10 and 13, and pharmaceutically acceptable salts thereof, for use as, for example, modulators for GABA type-A receptors. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
FILED	Friday, February 14, 2014
APPL NO	14/767235
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 35/42 (20130101) C07C 43/307 (20130101) C07C 2603/26 (20170501) C07C 2603/40 (20170501) Steroids C07J 1/00 (20130101) Original (OR) Class C07J 13/002 (20130101) C07J 15/005 (20130101) C07J 21/00 (20130101) C07J 21/008 (20130101) C07J 31/006 (20130101) C07J 41/0094 (20130101) C07J 51/00 (20130101) C07J 61/00 (20130101) C07J 63/008 (20130101) C07J 71/001 (20130101) C07J 75/005 (20130101)
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10202424 — Recombinant viral vectors

US 10202424	Parks et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	International AIDS Vaccine Initiative (New York, New York)
ASSIGNEE(S)	International AIDS Vaccine Initiative (New York, New York)
INVENTOR(S)	Christopher L. Parks (New York, New York); Ivo Lorenz (New York, New York); Sanjay K. Phogat (New York, New York); Timothy J. Zamb (New York, New York)
ABSTRACT	The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
FILED	Monday, July 31, 2017
APPL NO	15/663867
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 2039/5256 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16051 (20130101) C12N 2740/16134 (20130101) C12N 2760/20234 (20130101) C12N 2760/20243 (20130101) C12N 2760/20251 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 2333/162 (20130101)
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10202425 — Selective recovery

US 10202425	Deverman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Mental Health (NIMH)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Benjamin E. Deverman (Pasadena, California); Paul H. Patterson (Altadena, California); Viviana Gradinaru (La Cañada Flintridge, California)
ABSTRACT	Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
FILED	Tuesday, March 20, 2018
APPL NO	15/926892
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/47 (20130101) A61K 38/50 (20130101) A61K 38/1709 (20130101) A61K 38/2093 (20130101) A61K 38/4813 (20130101) A61K 39/3955 (20130101) A61K 48/005 (20130101) A61K 48/0058 (20130101) Peptides C07K 7/06 (20130101) C07K 14/005 (20130101) Original (OR) Class C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/1068 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) C12N 2810/6027 (20130101) Enzymes C12Y 304/14009 (20130101) C12Y 305/01015 (20130101)
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10202430 — IgM-mediated receptor clustering and cell modulation

US 10202430	Pease et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Larry R. Pease (Rochester, Minnesota); Moses Rodriguez (Rochester, Minnesota)
ASSIGNEE(S)	MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (Rochester, Minnesota)
INVENTOR(S)	Larry R. Pease (Rochester, Minnesota); Moses Rodriguez (Rochester, Minnesota)
ABSTRACT	Materials and methods for using multivalent molecules (e.g., antibodies) to modulate cellular function. A molecule can be targeted to a particular type of cell, either through direct binding to an epitope on the surface of the cell, or through a linker that recognizes both the multivalent molecule and a marker on the cell surface. The invention provides a chimeric polypeptide comprising a first amino acid sequence and a second amino acid sequence, wherein the first amino acid sequence comprises an WIC Class I peptide sequence, and where the second amino acid sequence comprises an epitope to which a multivalent molecule binds, including wherein the multivalent molecule is an IgM antibody, including antibody hIgM22. The invention provides a linker molecule for targeting IgM antibody, including antibody hIgM22, to a cell in the oligodendrocyte lineage.
FILED	Friday, October 17, 2008
APPL NO	12/738774
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/4726 (20130101) Original (OR) Class
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10202441 — Methods, compositions and kits for treating a subject using a recombinant neutralizing binding protein

US 10202441	Shoemaker
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	TUFTS UNIVERSITY (Boston, Massachusetts)
ASSIGNEE(S)	TUFTS UNIVERSITY (Boston, Massachusetts)
INVENTOR(S)	Charles B. Shoemaker (North Grafton, Massachusetts)
ABSTRACT	Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes a disease agent that is a toxin, for example a Clostridium difficile toxin, a Shiga toxin, a ricin toxin, or an anthrax toxin.
FILED	Friday, June 24, 2016
APPL NO	15/191739
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/16 (20130101) C07K 16/18 (20130101) C07K 16/1228 (20130101) C07K 16/1278 (20130101) C07K 16/1282 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/31 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2319/40 (20130101)
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10202450 — Na_v1.7 antibodies and methods of using the same

US 10202450	Lee et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR) NIH Office of the Director (NIHOD) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Seok-Yong Lee (Durham, North Carolina); Ru-Rong Ji (Durham, North Carolina)
ABSTRACT	Disclosed herein is an antibody that binds to a voltage sensor paddle (VSP) of Nav1.7. Also disclosed herein are methods of treating pain, itch, neurogenic inflammation, or cough in a subject in need thereof. The methods include administrating the antibody to the subject.
FILED	Friday, September 05, 2014
APPL NO	14/916602
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 14/705 (20130101) C07K 16/28 (20130101) Original (OR) Class C07K 2299/00 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101)
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10202454 — Anti-PD-L1 monoclonal antibodies and fragments thereof

US 10202454	Freeman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Gordon J. Freeman (Brookline, Massachusetts); Arlene H. Sharpe (Brookline, Massachusetts)
ABSTRACT	The present invention is based, in part, on the discovery of monoclonal antibodies that specifically bind to the cytoplasmic domain of PD-L1 antibodies useful for diagnostic, prognostic, and therapeutic applications, as well as immunoglobulins polypeptides, and nucleic acids thereof.
FILED	Friday, October 24, 2014
APPL NO	15/029369
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/30 (20130101) C07K 16/2827 (20130101) Original (OR) Class C07K 16/3023 (20130101) C07K 16/3038 (20130101) C07K 16/3061 (20130101) C07K 16/3069 (20130101) C07K 2317/14 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) G01N 33/57484 (20130101) G01N 2333/70596 (20130101)
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10202457 — Anti-DEspR monoclonal antibody targeted therapy and imaging for cancer and stroke

US 10202457	Ruiz-Opazo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) National Heart, Lung, and Blood Institute (NHLBI) National Institute on Aging (NIA)
APPLICANT(S)	Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)	TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
INVENTOR(S)	Nelson Ruiz-Opazo (Westwood, Massachusetts); Victoria L. M. Herrera (Westwood, Massachusetts); Francis Joseph Carr (Balmedie, United Kingdom)
ABSTRACT	Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof derived from 6G8G7 and 7C5B2 anti-DEspR variant antibodies, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anti-DEspR antibodies and fragments thereof, and methods of their use in a variety of therapeutic applications. The compositions comprising the anti-DEspR antibodies and fragments thereof described herein are useful in diagnostic and imaging methods, such as DEspR-targeted molecular imaging of angiogenesis, and for companion diagnostic and/or in vivo non-invasive imaging and/or assessments.
FILED	Wednesday, August 24, 2016
APPL NO	15/245853
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/2863 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/52 (20130101) C07K 2317/53 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101)
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10202466 — Linked peptide fluorogenic biosensors

US 10202466	Berget
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR)
APPLICANT(S)	Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	CARNEGIE MELLON UNIVERSITY (Pittsburg, Pennsylvania)
INVENTOR(S)	Peter B. Berget (Philadelphia, Pennsylvania)
ABSTRACT	Biosensors, compositions comprising biosensors, methods of producing biosensors, and methods of using biosensors are disclosed. The biosensors comprise a fluorogen-activating peptide and a blocking peptide. The fluorogen-activating peptide and blocking peptide are covalently linked through a peptide linker. The blocking peptide associates with the fluorogen-activating peptide thereby blocking an active domain of the fluorogen-activating peptide when the linker is in an unmodified state. The peptide linker may contain an amino acid sequence that is specifically recognized as a modification substrate by a cognate enzyme. The fluorogen-activating peptide and the blocking peptide at least partially disassociate when the linker is modified by an enzyme, thereby allowing the fluorogen-activating peptide to bind a cognate fluorogen and modulate a fluorescence signal.
FILED	Monday, March 11, 2013
APPL NO	13/792534
ART UNIT	1677 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/44 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/573 (20130101) G01N 33/582 (20130101)
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10202507 — Antithrombotic compounds, methods and uses thereof

US 10202507	Kizhakkedathu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) Non-Profit Organization (NPO) American Heart Association (AHA)
APPLICANT(S)	The University of British Columbia (Vancouver, Canada); The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The University of British Columbia (Vancouver, Canada); The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Jayachandran Kizhakkedathu (New Westminster, Canada); James H. Morrissey (Champaign, Illinois); Richard J. Travers (Champaign, Illinois); Rajesh Shenoi (Richmond, Canada); Manu Thomas Kalathottukaren (Vancouver, Canada)
ABSTRACT	Provided herein are polymers and methods for their use in binding a phosphate containing biological macromolecules. Specifically, the methods and uses provided herein may be used to inhibit thrombin binding to polyphosphate or as an antithrombotic agent for the treatment of stroke, acute coronary syndrome, pulmonary embolism, atrial fibrillation, venous and arterial thromboembolism, disseminated intravascular coagulation (DIC), deep-vein thrombosis (DVT), peripheral artery disease, trauma-induced coagulopathy, extracorporeal circulation, cancer-associated thrombosis, sepsis, septic shock, Systemic Inflammatory Response Syndrome (SIRS), or inflammation.
FILED	Friday, May 29, 2015
APPL NO	15/313774
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/785 (20130101) Compositions of Macromolecular Compounds C08L 79/02 (20130101) Original (OR) Class C08L 101/005 (20130101) C08L 2203/02 (20130101) C08L 2207/53 (20130101)
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10202546 — Ligands for semiconductor nanocrystals

US 10202546	Han et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Hee-Sun Han (Cambridge, Massachusetts); Wenhao Liu (Cambridge, Massachusetts); Moungi G. Bawendi (Cambridge, Massachusetts)
ABSTRACT	In this invention, polyimidazole ligands (PILs) incorporating pendant imidazole moieties for nanocrystal binding and either sulfonatebetaine, carboxybetaine, or phosphocholinebetaine moieties for water-solubilization have been developed. Greatly enhanced stability of nanocrystals (both over time and in wide pH range) was achieved by incorporating multi-dentate imidazole moieties which provide strong coordination of the ligand to the nanocrystal surface and prevent aggregation of nanocrystals. Synthesis of betaine PILs was developed by modifying the synthesis of recently developed PEG containing poly imidazole ligands (PEG PILs). These nanocrystals are compact, water soluble, and biocompatible.
FILED	Monday, September 11, 2017
APPL NO	15/701425
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0041 (20130101) A61K 49/0054 (20130101) A61K 49/0093 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/60 (20130101) C08F 230/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/025 (20130101) Original (OR) Class C09K 11/565 (20130101) C09K 11/883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101)
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10202568 — Automated cell culture system and method

US 10202568	Conway et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	INVIVOSCIENCES INC. (Madison, Wisconsin)
ASSIGNEE(S)	INVIVOSCIENCES INC. (McFarland, Wisconsin)
INVENTOR(S)	Michael Conway (Madison, Wisconsin); Michael Gerger (Madison, Wisconsin); Tetsuro Wakatsuki (Madison, Wisconsin)
ABSTRACT	An automated method for culturing stem cells using a robotic liquid handling system including a translatable bed and a movable multichannel pipette. The method includes the steps of: locating a first multi-well cell culture plate and a multi-trough plate on the bed; placing a suspension of stem cells in at least one trough of the multi-trough plate; using the multi-channel pipette, transferring a portion of the suspension of stem cells to each well of the first multi-well cell culture plate such that at least two of the wells of the first multi-well cell culture plate have different densities of stem cells; selecting a well of the first multi-well cell culture plate having a desired stem cell density; locating a second multi-well cell culture plate; and using the multi-channel pipette, transferring the cells of the selected well to a plurality of wells of the second multi-well cell culture plate.
FILED	Tuesday, August 12, 2014
APPL NO	14/910641
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) Original (OR) Class C12M 33/06 (20130101) C12M 33/07 (20130101) C12M 41/12 (20130101) C12M 41/36 (20130101) C12M 41/48 (20130101)
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10202569 — Radial microfluidic devices and methods of use

US 10202569	Novak et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of Health and Human Services (HHS) Food and Drug Administration (FDA)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S)	Richard Novak (Jamaica Plain, Massachusetts); David Conegliano (Cambridge, Massachusetts); Liliana Teixeira (Cambridge, Massachusetts); Donald E. Ingber (Boston, Massachusetts)
ABSTRACT	A microfluidic device for simulating a function or response of a tissue is disclosed. The device includes an inlet for receiving a fluid in the device, and an outlet for removing the fluid from the device. The device further includes a fluid channel in fluid communication with the inlet and the outlet for flowing the fluid through the device. The fluid channel defines a chamber well that receives cells associated with the tissue. The device also includes an interface structure between the fluid channel and the chamber well for permitting migration of at least one of cells, particulates, chemicals, molecules, liquids, or gases between the fluid within the fluid channel and the chamber well.
FILED	Friday, July 22, 2016
APPL NO	15/217714
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/0694 (20130101) B01L 2300/0851 (20130101) B01L 2300/0877 (20130101) B01L 2300/0887 (20130101) B01L 2400/086 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101)
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10202571 — Co-incubating confined microbial communities

US 10202571	Boedicker et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	James Q. Boedicker (Chicago, Illinois); Rustem F. Ismagilov (Pasadena, California); Hyun Jung Kim (Chicago, Illinois)
ABSTRACT	This invention provides devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices.
FILED	Monday, June 22, 2015
APPL NO	14/746494
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 1/14 (20130101) C12M 23/34 (20130101) C12M 25/01 (20130101) C12M 35/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/38 (20130101) C12N 11/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 39/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/54313 (20130101)
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10202588 — Therapeutic nuclease compositions and methods

US 10202588	Ledbetter et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Jeffrey A. Ledbetter (Seattle, Washington); Martha Hayden-Ledbetter (Seattle, Washington); Keith Elkon (Seattle, Washington); Xizhang Sun (Seattle, Washington)
ASSIGNEE(S)	The University of Washington (Seattle, Washington)
INVENTOR(S)	Jeffrey A. Ledbetter (Seattle, Washington); Martha Hayden-Ledbetter (Seattle, Washington); Keith Elkon (Seattle, Washington); Xizhang Sun (Seattle, Washington)
ABSTRACT	Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
FILED	Friday, April 27, 2012
APPL NO	13/822215
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 47/68 (20170801) A61K 47/6815 (20170801) Peptides C07K 16/44 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class Enzymes C12Y 301/27005 (20130101)
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10202589 — Engineered CRISPR-Cas9 nucleases with altered PAM specificity

US 10202589	Joung et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	J. Keith Joung (Winchester, Massachusetts); Benjamin Kleinstiver (Medford, Massachusetts)
ABSTRACT	Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
FILED	Thursday, March 03, 2016
APPL NO	15/060448
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2227/40 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 2319/71 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/63 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 2800/22 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 301/00 (20130101)
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10202593 — Evolved sortases and uses thereof

US 10202593	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	David R. Liu (Lexington, Massachusetts); Brent M. Dorr (Somerville, Massachusetts)
ABSTRACT	Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind recognitions motifs comprising a LAXT or LPXS sequence. Also provided are methods (e.g., orthogonal transpeptidation and diagnostics methods) for using such sortases. Kits comprising materials, reagents, and cells for carrying out the methods described herein are also provided.
FILED	Friday, September 19, 2014
APPL NO	15/022985
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/473 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) C12P 21/02 (20130101) Enzymes C12Y 304/2207 (20130101)
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10202600 — AAV-based treatment of cholesterol-related disorders

US 10202600	Gao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Guangping Gao (Westborough, Massachusetts); Phillip D. Zamore (Northborough, Massachusetts); Jun Xie (Shrewsbury, Massachusetts)
ABSTRACT	The invention in some aspects relates to methods and compositions for assessing the effectiveness of miRNA inhibitors. In other aspects of the invention, methods and compositions for treating cholesterol related disorders are provided. In one aspect of the invention, miRNA inhibitors against miR-122 and rAAV-based compositions comprising the same are provided.
FILED	Thursday, January 14, 2016
APPL NO	14/995699
ART UNIT	1674 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2320/32 (20130101) C12N 2330/51 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6897 (20130101)
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10202618 — Method of treating type I diabetes using an AAV vector encoding uracortin 2

US 10202618	Hammond et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	H. Kirk Hammond (La Jolla, California); Mei Hua Gao (San Diego, California)
ABSTRACT	In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence; or an expression vehicle, a vector, a recombinant virus, or equivalent, having contained therein a paracrine-encoding nucleic acid or gene, and the expression vehicle, vector, recombinant virus, or equivalent can express the paracrine-encoding nucleic acid or gene in a cell or in vivo; and administering or delivering the paracrine polypeptide -encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence, or the expression vehicle, vector, recombinant virus, or equivalent, to an individual or a patient in need thereof, thereby treating, ameliorating or protecting (preventing) the individual or patient against the disease, infection or condition responsive to an increased paracrine polypeptide level.
FILED	Friday, June 16, 2017
APPL NO	15/625719
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/65 (20130101) A61K 31/436 (20130101) A61K 38/25 (20130101) A61K 38/30 (20130101) A61K 38/52 (20130101) A61K 38/2221 (20130101) A61K 38/2228 (20130101) A61K 38/2242 (20130101) A61K 47/6901 (20170801) A61K 48/00 (20130101) A61K 48/005 (20130101) Peptides C07K 14/65 (20130101) C07K 14/075 (20130101) C07K 14/57509 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/861 (20130101) Original (OR) Class C12N 2710/10343 (20130101) C12N 2750/14143 (20130101) C12N 2830/003 (20130101)
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10202626 — Compositions and methods for producing benzylisoquinoline alkaloids

US 10202626	Smolke et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Christina D. Smolke (Menlo Park, California); Kristy M. Hawkins (Oakland, California)
ABSTRACT	The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise one, two or more heterologous coding sequences wherein each of the heterologous coding sequences encodes an enzyme involved in the metabolic pathway of a benzylisoquinoline, or its precursors or intermediates from a starting compound. The invention also relates to methods of producing the benzylisoquinoline, as well as select precursors and intermediates thereof by culturing the host cells under culture conditions that promote expression of the enzymes that produce the benzylisoquinoline or precursors or intermediates thereof.
FILED	Wednesday, March 23, 2016
APPL NO	15/078874
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0022 (20130101) C12N 9/0059 (20130101) C12N 9/88 (20130101) C12N 9/1007 (20130101) C12N 9/1096 (20130101) C12N 15/81 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/24 (20130101) C12P 13/001 (20130101) C12P 17/12 (20130101) Original (OR) Class C12P 17/182 (20130101)
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10202628 — Assembly of nucleic acid sequences in emulsions

US 10202628	Church et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	George M. Church (Brookline, Massachusetts); Richard C. Terry (Carlisle, Massachusetts); Sriram Kosuri (Cambridge, Massachusetts); Di Zhang (Boston, Massachusetts)
ABSTRACT	Methods and compositions for synthesizing nucleic acid sequences in an emulsion are provided.
FILED	Thursday, February 14, 2013
APPL NO	14/379005
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1031 (20130101) C12N 15/1031 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) C12Q 1/6851 (20130101) C12Q 2521/313 (20130101) C12Q 2521/313 (20130101) C12Q 2525/131 (20130101) C12Q 2525/131 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/159 (20130101) C12Q 2563/159 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101)
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10202640 — Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing

US 10202640	Davis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Mark M. Davis (Atherton, California); Jacob Glanville (San Francisco, California); Arnold Han (Los Altos Hills, California)
ABSTRACT	Methods and oligonucleotide reagents for analyzing individual T cells are disclosed. In particular, the present disclosure provides methods for analyzing individual T cells using high-throughput multiplex amplification and deep sequencing of nucleic acids encoding T cell receptors (TCRs) and various other T cell phenotypic markers. The present disclosure further provides methods of reconstituting TCRs from individual T cells for functional studies, ligand discovery, or screening therapeutics.
FILED	Thursday, April 30, 2015
APPL NO	14/700797
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/686 (20130101) C12Q 2525/191 (20130101) C12Q 2535/122 (20130101) C12Q 2537/143 (20130101) C12Q 2563/185 (20130101)
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10202643 — Genetic alterations in glioma

US 10202643	Alter
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	UNIVERSITY OF UTAH RESARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
INVENTOR(S)	Orly Alter (Salt Lake City, Utah)
ABSTRACT	Methods and genetic sequences are described for use in determining the diagnosis, subtype, prognosis, and disease course of high-grade gliomas, such as glioblastoma multiforme. One such method includes determining increased expression of at least one gene on a chromosome segment in cells of the glioma, the segment being 17:57,851,812-17:57,973,757; 7:127,892,509-7:127,947,649; 12:33,854-12:264,310; or 19:33,329,393-19:35,322,055; and estimating, based on the expression, a predicted length of survival, a probability of survival, or a predicted response to a therapy for the glioma.
FILED	Wednesday, October 31, 2012
APPL NO	14/354543
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6809 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2537/165 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Enzymes C12Y 201/01 (20130101) C12Y 207/11001 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) Technologies for Adaptation to Climate Change Y02A 90/26 (20180101)
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10202645 — Compositions, devices, systems, and methods for using a nanopore

US 10202645	Akeson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Mark A. Akeson (Santa Cruz, California); Daniel Branton (Lexington, Massachusetts); David W. Deamer (Santa Cruz, California); Seiko L. Endo (Nagareyama, Japan)
ABSTRACT	Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
FILED	Friday, September 22, 2017
APPL NO	15/713535
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/54 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2522/101 (20130101) C12Q 2565/631 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3278 (20130101) G01N 27/4166 (20130101) G01N 33/48721 (20130101)
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10202647 — Mutations in DSTYK cause dominant urinary tract malformations

US 10202647	Gharavi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Ali Gharavi (New York, New York); Simone Sanna-Cherchi (New York, New York)
ABSTRACT	Congenital abnormalities of the kidney or the urinary tract (CAKUT) are the most common cause of pediatric kidney failure. These disorders are highly heterogenous, and their etiology is poorly understood. Dual serine/threonine and tyrosine protein kinase (DSTYK) mutations were detected in 2.2% of patients with congenital abnormalities of the kidney and urinary tract, suggesting that DSTYK is a major determinant of human urinary development, downstream of fibroblast growth factor (FGF) signaling. Methods and kits are provided for identifying and treating subjects at greater risk of developing CAKUT based on the presence of DSTYK mutations. Techniques include obtaining a biological sample from a subject and determining if the biological sample indicates a mutation of a gene for DSTYK. If it is determined that the biological sample indicates the mutation of the gene for DSTYK, then it is determined that the subject has or is at risk of developing CAKUT.
FILED	Monday, April 14, 2014
APPL NO	14/783078
ART UNIT	1674 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 16/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2320/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 2333/91 (20130101) G01N 2333/912 (20130101) G01N 2800/34 (20130101) G01N 2800/347 (20130101)
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10202654 — Methods for detecting Legionella nucleic acids in a sample

US 10202654	Winchell et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America as represented by the Secretary of the Dept. of Health and Human Services (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Department of Health and Human Services (Washington, District of Columbia)
INVENTOR(S)	Jonas M. Winchell (Lilburn, Georgia); Alvaro J. Benitez (Kennesaw, Georgia)
ABSTRACT	Methods for detecting Legionella (such as Legionella spp., Legionella pneumophila, Legionella pneumophila serogroup 1, Legionella bozemanii, Legionella dumoffii, Legionella feeleii, Legionella longbeachae, and/or Legionella micdadei) are disclosed. A sample suspected of containing one or more Legionella nucleic acids is screened for the presence or absence of that nucleic acid. Determining whether Legionella nucleic acid is present in the sample can be accomplished by contacting the sample with detectably labeled probes capable of hybridizing to a Legionella nucleic acid and detecting hybridization between the probes and nucleic acids in the sample. Detection of hybridization indicates that a Legionella nucleic acid is present in the sample. Also disclosed are probes and primers for the detection of Legionella, and kits that contain the disclosed probes and/or primers.
FILED	Monday, June 20, 2016
APPL NO	15/186979
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/16 (20130101)
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10202657 — Adeno-associated virus virions with variant capsid and methods of use thereof

US 10202657	Schaffer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	David V. Schaffer (Danville, California); Ryan R. Klimczak (San Francisco, California); James T. Koerber (San Francisco, California); John G. Flannery (Berkeley, California); Deniz Dalkara Mourot (Berkeley, California); Meike Visel (El Cerrito, California); Leah C. T. Byrne (Berkeley, California)
ABSTRACT	The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
FILED	Tuesday, August 23, 2016
APPL NO	15/244884
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 38/1709 (20130101) A61K 48/0008 (20130101) A61K 48/0025 (20130101) A61K 48/0075 (20130101) Peptides C07K 14/005 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 15/115 (20130101) C12N 2310/14 (20130101) C12N 2310/16 (20130101) C12N 2320/32 (20130101) C12N 2750/14021 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) C12N 2750/14152 (20130101) C12N 2810/40 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/701 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) G01N 33/5058 (20130101)
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10203274 — Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded (TRUME) light

US 10203274	Ruan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Haowen Ruan (Pasadena, California); Mooseok Jang (Pasadena, California); Changhuei Yang (South Pasadena, California); Daifa Wang (Pasadena, California)
ABSTRACT	A method for irradiating scattering medium, including modifying a particle's response to electromagnetic radiation irradiating the particle in a scattering medium, wherein the electromagnetic radiation is scattered by the scattering medium, and modulated by the modifying, into scattered electromagnetic radiation comprising a scattered field; forming a phase conjugate field, wherein the phase conjugate field is a phase conjugate of the scattered field; and irradiating the scattering medium with the phase conjugate field, wherein the phase conjugate field forms a focus at a target defined by the particle.
FILED	Monday, June 13, 2016
APPL NO	15/181160
ART UNIT	2877 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) Original (OR) Class G01N 21/453 (20130101) G01N 21/4788 (20130101) G01N 21/4795 (20130101) G01N 2021/473 (20130101)
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10203322 — Method for identifying subjects with increased risk of ST-segment elevation myocardial infarction (STEMI) and identifying subjects likely to respond to particular treatments

US 10203322	Boutaud et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Olivier Boutaud (Nashville, Tennessee); Elias V. Haddad (Nashville, Tennessee); Eitan Friedman (Nashville, Tennessee)
ABSTRACT	A method for identifying an increased risk of developing ST-Segment Elevation Myocardial Infarction (STEMI) in a subject involves obtaining a platelet-containing plasma sample from the subject; determining a Prostaglandin E2 (PGE2) phenotype of the platelets of the subject; and identifying the subject has having an increased risk of developing STEMI when the subject has a potentiating phenotype, as compared to the risk of a subject having an inhibitory phenotype.
FILED	Tuesday, January 16, 2018
APPL NO	15/872864
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) Original (OR) Class G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/324 (20130101)
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10203329 — Biofilm formation to define risk for colon cancer

US 10203329	Sears et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Cynthia L. Sears (Baltimore, Maryland); Drew M. Pardoll (Brookeville, Maryland); Christine Craig (Baltimore, Maryland); Elizabeth Wick (Baltimore, Maryland)
ABSTRACT	Methods of identifying subjects at increased risk of cancer, based upon detection of biofilms and/or biofilm-associated microbes within a subject, are disclosed. Therapies designed to prevent formation and/or reduce the size of biofilms in a subject identified to be at increased risk of cancer based upon detection of biofilms and/or biofilm-associated microbes are disclosed. In particular embodiments, the invention provides for identification of a subject at elevated risk of developing or having colorectal cancer and/or a colorectal adenoma, based upon detection of a biofilm and/or biofilm-associated bacteria within the gastrointestinal tract of the subject (optionally, within a biopsy specimen and/or stool sample of such subject). Therapies involving administration of an antibiotic agent and/or a probiotic agent to a subject, to prevent or reduce biofilm formation within the gastrointestinal tract of the subject, optionally provided in combination with additional cancer therapy, are also disclosed.
FILED	Thursday, September 11, 2014
APPL NO	15/021313
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/43 (20130101) A61K 31/165 (20130101) A61K 31/407 (20130101) A61K 31/546 (20130101) A61K 31/7048 (20130101) A61K 31/7056 (20130101) A61K 35/741 (20130101) A61K 35/742 (20130101) A61K 35/744 (20130101) A61K 35/745 (20130101) A61K 35/747 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57419 (20130101) Original (OR) Class G01N 2800/50 (20130101)
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10203331 — Single cell drug response measurements via live cell interferometry

US 10203331	Reed et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Jason C. Reed (Los Angeles, California); Michael A. Teitell (Tarzana, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Jason C. Reed (Los Angeles, California); Michael A. Teitell (Tarzana, California)
ABSTRACT	A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change in physical mass, whether cancerous or physiologic, is difficult to measure directly with traditional techniques. Embodiments of the invention provide live cell interferometry (LCI) for rapid, realtime quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides a conceptual advance for assessing cell populations to identify, monitor, and measure single cell responses, such as to therapeutic drugs.
FILED	Thursday, August 02, 2012
APPL NO	14/235547
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/0209 (20130101) G01B 9/02057 (20130101) G01B 9/02089 (20130101) G01B 11/0675 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/5026 (20130101) G01N 33/57492 (20130101) Original (OR) Class
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10203334 — Methods and compositions related to nucleic acid binding assays

US 10203334	Arya et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Nubad, LLC (Greenville, South Carolina)
ASSIGNEE(S)	Nubad, LLC (Greenville, South Carolina)
INVENTOR(S)	Dev P. Arya (Greenville, South Carolina); Frank Anderson Norris (Anderson, South Carolina); Jason Derrick Watkins (Greenville, South Carolina)
ABSTRACT	Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.
FILED	Thursday, March 31, 2016
APPL NO	15/086935
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6486 (20130101) G01N 33/582 (20130101) Original (OR) Class G01N 2021/6439 (20130101)
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10203335 — Fluorescent labeling of transfer RNA and study of protein synthesis

US 10203335	Cooperman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The Trustees Of The University Of Pennsylvania (Philadelphia, Pennsylvania); Anima Cell Metrology, Inc. (Basking Ridge, New Jersey)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Anima Cell Metrology (Basking Ridge, New Jersey)
INVENTOR(S)	Barry S. Cooperman (Penn Valley, Pennsylvania); Zeev Smilansky (D.N. Emek Sorek, Israel); Yale E. Goldman (Merion, Pennsylvania); Dongli Pan (Brookline, Massachusetts)
ABSTRACT	Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system. The disclosed methods are useful in single molecule as well as in ensemble settings.
FILED	Thursday, February 09, 2017
APPL NO	15/428750
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) C12P 21/02 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) Original (OR) Class G01N 33/5308 (20130101) G01N 33/6803 (20130101)
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10203382 — Wirelessly powered magnetic resonance imaging signal amplification system for ingestible devices having L-C mesh circuit

US 10203382	Qian et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the secretary, Dept. of Health and Human Services (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
INVENTOR(S)	Chunqi Qian (Rockville, Maryland); Joe Murphy-Boesch (Rockview, Maryland); Alan Koretsky (Bethesda, Maryland); Stephen John Dodd (Bethesda, Maryland)
ABSTRACT	An implantable parametric circuit enables local signal amplification and wireless transmission of RF signals in connection with magnetic resonance imaging systems. The parametric circuit detects RF signal detected during magnetic resonance imaging procedure, amplifies the detected RF signal, and transmits the amplified RF signal in a wireless manner to an external pick-up coil. The parametric amplifier is also configured to use another RF signal generated by an external source as the primary power source. As a result, implanted or catheter coils could be used as a wireless signal transducer without the need for a battery or a power connection.
FILED	Wednesday, November 29, 2017
APPL NO	15/825316
ART UNIT	3737 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/00 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/285 (20130101) G01R 33/3621 (20130101) G01R 33/3692 (20130101) Original (OR) Class
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10203389 — Method and system for monitoring glucose transport and metabolism by spin-lock magnetic resonance

US 10203389	Jin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute on Drug Abuse (NIDA) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Tao Jin (Pittsburgh, Pennsylvania); Seong-Gi Kim (Pittsburgh, Pennsylvania); Hunter S. Mehrens (Pittsburgh, Pennsylvania); Kristy S. Hendrich (Pittsburgh, Pennsylvania)
ABSTRACT	A method of monitoring glucose transport and/or metabolism in a tissue or an organ of a subject using spin-locking magnetic resonance (MR) includes acquiring pre-glucose MR data by executing a pre-glucose chemical exchange spin-lock (CESL) pulse sequence a number of times each including applying pre-glucose chemical exchange spin-lock pulse sequence irradiation to the tissue or the organ, administering glucose to the subject, acquiring post-glucose MR data by executing a post-glucose chemical exchange spin-lock (CESL) pulse sequence a number of times each including applying post-glucose chemical exchange spin-lock (CESL) pulse sequence irradiation to the tissue or the organ, and using the pre-glucose MR data and the post-glucose MR data to generate a measure of glucose transport, glucose metabolism or both glucose transport and glucose metabolism in the tissue or the organ.
FILED	Wednesday, April 22, 2015
APPL NO	15/304948
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4866 (20130101) A61B 5/14532 (20130101) A61B 2576/026 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/485 (20130101) G01R 33/5605 (20130101) Original (OR) Class G01R 33/56341 (20130101)
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10203392 — Dynamic 3D MRI data sampling

US 10203392	Zhu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
INVENTOR(S)	Yinghua Zhu (Fremont, California); Yi Guo (Los Angeles, California); Krishna S. Nayak (Long Beach, California); Robert Marc Lebel (Calgary, Canada)
ABSTRACT	A magnetic resonance imaging system may include: a magnet; gradient coils; an RF pulse transmitter; an RF receiver that receives MR signals from tissue that has been exposed to RF pulses from the RF pulse generator, gradient fields from the gradient coils, and a magnetic field from the magnet; a system controller that controls the magnet, gradient coils, RF pulse transmitter, and RF receiver so as to generate data representative of at least a portion of the composition of an object, including controlling the gradient coils and RF receiver so as to cause MRI data to be acquired that includes information about at least one attribute of the object at different points in time and that represents an incomplete sample of a portion of k-space that is a Fourier transform of the object; and a data processing system that generates one or more images of at least a portion of the object based on the MRI data.
FILED	Monday, March 21, 2016
APPL NO	15/075716
ART UNIT	2868 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4826 (20130101) G01R 33/5635 (20130101) Original (OR) Class G01R 33/56325 (20130101)
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10203661 — Systems and methods for performing self-interference incoherent digital holography

US 10203661	Kim
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida)
INVENTOR(S)	Myung K. Kim (Tampa, Florida)
ABSTRACT	In one embodiment, a self-interference incoherent digital holography system including a light sensor and a diffractive filter configured to receive light from an object to be holographically imaged and generate holographic interference patterns on the light sensor. A self-interference incoherent digital holography system comprising: a light sensor; and a diffractive filter configured to receive light from an object to be holographically imaged and generate holographic interference patterns on the sensor.
FILED	Wednesday, July 08, 2015
APPL NO	15/100385
ART UNIT	2872 — Optics
CURRENT CPC	Holographic Processes or Apparatus G03H 1/0005 (20130101) G03H 1/06 (20130101) G03H 1/22 (20130101) G03H 1/041 (20130101) Original (OR) Class G03H 1/0443 (20130101) G03H 5/00 (20130101) G03H 2001/005 (20130101) G03H 2001/0428 (20130101) G03H 2001/0441 (20130101) G03H 2001/0447 (20130101) G03H 2001/0452 (20130101) G03H 2210/44 (20130101) G03H 2222/14 (20130101) G03H 2223/23 (20130101) G03H 2223/52 (20130101) G03H 2226/11 (20130101)
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10204413 — System and method that expands the use of polar dynamic programming to segment complex shapes

US 10204413	Rosado-Toro et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
INVENTOR(S)	Jose Rosado-Toro (Tucson, Arizona); Jeffrey J. Rodriguez (La Jolla, California); Ryan Avery (Tucson, Arizona); Aiden Abidov (Tucson, Arizona)
ABSTRACT	The present invention provides a system and method that uses polar dynamic programming PDP (PDP) method to generate a segmented image of a shape.
FILED	Friday, June 30, 2017
APPL NO	15/639535
ART UNIT	2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/12 (20170101) G06T 7/143 (20170101) G06T 7/174 (20170101) G06T 7/557 (20170101) G06T 2207/10016 (20130101) G06T 2207/10088 (20130101) G06T 2207/20101 (20130101) G06T 2207/30048 (20130101)
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10205304 — Widely tunable swept source

US 10205304	Jayaraman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Eye Institute (NEI)
APPLICANT(S)	Praevium Research, Inc. (Santa Barbara, California); Thorlabs, Inc. (Newton, New Jersey)
ASSIGNEE(S)	PRAEVIUM RESEARCH, INC. (Santa Barbara, California); THORLABS, INC. (Newton, New Jersey)
INVENTOR(S)	Vijaysekhar Jayaraman (Goleta, California); Christopher Burgner (Santa Barbara, California); Demis John (Goleta, California); Peter Heim (Jessup, Maryland); Alex Ezra Cable (Newton, New Jersey)
ABSTRACT	A high-speed, single-mode, high power, reliable and manufacturable wavelength-tunable light source operative to emit wavelength tunable radiation over a wavelength range contained in a wavelength span between about 950 nm and about 1150 nm, including a vertical cavity laser (VCL), the VCL having a gain region with at least one compressively strained quantum well containing Indium, Gallium, and Arsenic.
FILED	Tuesday, August 22, 2017
APPL NO	15/683435
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0059 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02091 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/2059 (20130101) H01S 5/3095 (20130101) H01S 5/18308 (20130101) H01S 5/18311 (20130101) H01S 5/18341 (20130101) H01S 5/18366 (20130101) Original (OR) Class H01S 5/18369 (20130101) H01S 5/18372 (20130101) H01S 5/18377 (20130101)
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Department of Defense (DOD)

10201439 — Dynamic support apparatus and system

US 10201439	Streeter et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Research, Development and Engineering Command (RDECOM)
APPLICANT(S)	DEKA Products Limited Partnership (Manchester, New Hampshire)
ASSIGNEE(S)	DEKA PRODUCTS LIMITED PARTNERSHIP (Manchester, New Hampshire)
INVENTOR(S)	Alexander D. Streeter (Concord, New Hampshire); David E. Altobelli (Hollis, New Hampshire); N. Christopher Perry (Manchester, New Hampshire)
ABSTRACT	A dynamic support system includes a control system for controlling inflation and deflation of at least one actuator having an inlet connectable to the a control unit of the dynamic support system. The control unit may be in communication with a sensor and may control inflation and deflation of the at least one actuator in response to information provided by the sensor.
FILED	Friday, February 13, 2015
APPL NO	14/622102
ART UNIT	3738 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/54 (20130101) A61F 2/68 (20130101) A61F 2/76 (20130101) A61F 2/5044 (20130101) A61F 2/7812 (20130101) A61F 2/7843 (20130101) Original (OR) Class A61F 5/012 (20130101) A61F 5/34 (20130101) A61F 2002/704 (20130101) A61F 2002/741 (20130101) A61F 2002/745 (20130101) A61F 2002/747 (20130101) A61F 2002/748 (20130101) A61F 2002/5083 (20130101) A61F 2002/7635 (20130101) A61F 2002/7655 (20130101) A61F 2007/006 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 39/00 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49826 (20150115)
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10202287 — Ammonia sequestering system

US 10202287	Guy et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The United States of America as Represented by The Secretary of The Army (Washington, District of Columbia)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia)
INVENTOR(S)	Kathryn A. Guy (Champaign, Illinois); Martin Page (Urbana, Illinois)
ABSTRACT	The present invention is an ammonia sequestering system including a system controller connected to a plurality of flow control valves, a feed stream extending through a system inlet, and a system outlet. The feed stream is a liquid contaminated with ammonia. At least one exchange column is located between the system inlet and the system outlet. The ion column includes an ion exchange material, a column inlet connected to one of the flow control valves, and a column outlet connected to another of the flow control valves. The system also includes a regenerant stream of an aqueous solution of sodium cations, as well as an ammonia brine stream made up of the regenerant stream and ammonia.
FILED	Friday, March 25, 2016
APPL NO	15/081321
ART UNIT	1778 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/02 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/02 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/008 (20130101) C02F 1/42 (20130101) C02F 1/281 (20130101) Original (OR) Class C02F 1/46104 (20130101) C02F 2001/422 (20130101) C02F 2101/16 (20130101) C02F 2201/46115 (20130101) C02F 2209/14 (20130101) C02F 2209/40 (20130101) C02F 2303/16 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/251 (20130101) G01N 33/18 (20130101)
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10202478 — Multigraft copolymer superelastomers by emulsion polymerization

US 10202478	Mays et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF)
APPLICANT(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
INVENTOR(S)	Jimmy W. Mays (Knoxville, Tennessee); Nam-Goo Kang (Knoxville, Tennessee); Qiuyu Zhang (Xi'an, China PRC); Wenwen Wang (Xi'an, China PRC)
ABSTRACT	Multigraft copolymers having various structures, e.g., comb and centipede structures, can be prepared from emulsion copolymerization of monomers and macromonomers. The emulsion copolymerization can be initiated by a thermally activated radical initiator or a redox initiation system. The multigraft copolymers can have high molecular weight and/or a large number of branch points. Elastomer or adhesive compositions of the copolymers can be prepared. Also described are poly(n-alkyl acrylate-graft-styrene) multigraft copolymers.
FILED	Friday, June 19, 2015
APPL NO	15/320530
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 12/08 (20130101) C08F 12/22 (20130101) C08F 12/32 (20130101) C08F 220/18 (20130101) C08F 236/08 (20130101) C08F 290/044 (20130101) Original (OR) Class C08F 290/044 (20130101) C08F 290/044 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 155/005 (20130101)
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10202484 — Shape-memory-self-healing polymers (SMSHPS)

US 10202484	Sodano et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
INVENTOR(S)	Henry A. Sodano (Ann Arbor, Michigan); Yunseon Heo (Gainesville, Florida)
ABSTRACT	A shape-memory self-healing polymeric network (SMSHP) is useful as a molded part, a coating, or as a matrix for a composite that can be repaired by heating to a controlled temperature. The SMSHP has thermally reversible repeating units where a thermally reversible adduct is situated between two common linking units formed during a polymerization process between thermally reversible monomers and cross-linking monomers. Optionally, other repeating units can be present from other monomers. Shape-memory results when the SMSHP is warmed to a temperature in excess of its glass transition temperature and self-healing then proceeds when a higher temperature is achieved where thermally reversible adducts dissociates to complementary groups that subsequently reform the adduct without distortion of the memorized shape. The thermally reversible adducts can be Diels-Alder (DA) adducts in a polyurethane, poly urea, or amine epoxy SMSHP network.
FILED	Wednesday, May 18, 2016
APPL NO	15/157839
ART UNIT	1763 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/0895 (20130101) C08G 18/3206 (20130101) C08G 18/3278 (20130101) C08G 18/3819 (20130101) C08G 18/3846 (20130101) Original (OR) Class C08G 18/7893 (20130101) C08G 2280/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 5/042 (20130101) C08J 2375/04 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 175/04 (20130101)
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10202569 — Radial microfluidic devices and methods of use

US 10202569	Novak et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of Health and Human Services (HHS) Food and Drug Administration (FDA)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S)	Richard Novak (Jamaica Plain, Massachusetts); David Conegliano (Cambridge, Massachusetts); Liliana Teixeira (Cambridge, Massachusetts); Donald E. Ingber (Boston, Massachusetts)
ABSTRACT	A microfluidic device for simulating a function or response of a tissue is disclosed. The device includes an inlet for receiving a fluid in the device, and an outlet for removing the fluid from the device. The device further includes a fluid channel in fluid communication with the inlet and the outlet for flowing the fluid through the device. The fluid channel defines a chamber well that receives cells associated with the tissue. The device also includes an interface structure between the fluid channel and the chamber well for permitting migration of at least one of cells, particulates, chemicals, molecules, liquids, or gases between the fluid within the fluid channel and the chamber well.
FILED	Friday, July 22, 2016
APPL NO	15/217714
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/0694 (20130101) B01L 2300/0851 (20130101) B01L 2300/0877 (20130101) B01L 2300/0887 (20130101) B01L 2400/086 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101)
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10202605 — Methods of identifying and treating poor-prognosis cancers

US 10202605	Kang et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Yibin Kang (Princeton, New Jersey); Guohong Hu (Piscataway, New Jersey)
ABSTRACT	The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis by combating metastasis and abrogating chemoresistance in cancer cells. Embodiments of the present invention provide an objective means of prognostication regarding the long-term outcome of an incident of cancer, breast cancer in particular. Therapeutic modalities include immunotherapy and anti-sense therapy. Prognosis is determined by measuring the number of copies of the metadherin gene in the patient's cells.
FILED	Wednesday, February 21, 2018
APPL NO	15/901174
ART UNIT	1674 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/337 (20130101) A61K 31/704 (20130101) A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2320/30 (20130101) C12N 2320/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101)
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10202628 — Assembly of nucleic acid sequences in emulsions

US 10202628	Church et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	George M. Church (Brookline, Massachusetts); Richard C. Terry (Carlisle, Massachusetts); Sriram Kosuri (Cambridge, Massachusetts); Di Zhang (Boston, Massachusetts)
ABSTRACT	Methods and compositions for synthesizing nucleic acid sequences in an emulsion are provided.
FILED	Thursday, February 14, 2013
APPL NO	14/379005
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1031 (20130101) C12N 15/1031 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) C12Q 1/6851 (20130101) C12Q 2521/313 (20130101) C12Q 2521/313 (20130101) C12Q 2525/131 (20130101) C12Q 2525/131 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/159 (20130101) C12Q 2563/159 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101)
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10202631 — Multi-tiered, high through-put screen for compounds effective against bacterial biofilm compounds effective for inhibiting and eradicating bacterial biofilm

US 10202631	Hassett et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	University of Cincinnati (Cincinnati, Ohio); The United States of America, as Represented by the Secretary of the Air Force (Washington, District of Columbia)
ASSIGNEE(S)	University of Cincinnati (Cincinnati, Ohio); The United States of America as Represented by the Secretary of the Air Force (Washington, District of Columbia)
INVENTOR(S)	Daniel J. Hassett (Cincinnati, Ohio); Thomas J. Lamkin (Cincinnati, Ohio); Warunya Panmanee (Cincinnati, Ohio); Deborah E. Taylor (Cincinnati, Ohio); Chloe J. A. Shea (Cincinnati, Ohio)
ABSTRACT	A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each tier includes three specific biological process assays. The tier levels are a primary screen, a confirmation screen, and a dose-response screen, and the biological process assays include as says for total bacterial growth, bacterial metabolic activity, and biofilm formation.
FILED	Friday, March 14, 2014
APPL NO	14/776043
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/10 (20130101) A01N 37/28 (20130101) A01N 41/06 (20130101) A01N 43/12 (20130101) A01N 43/38 (20130101) A01N 43/42 (20130101) A01N 43/44 (20130101) A01N 43/52 (20130101) A01N 43/54 (20130101) A01N 43/56 (20130101) A01N 43/80 (20130101) A01N 43/82 (20130101) A01N 43/90 (20130101) A01N 47/38 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/175 (20130101) A61K 31/216 (20130101) A61K 31/343 (20130101) A61K 31/404 (20130101) A61K 31/425 (20130101) A61K 31/435 (20130101) A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4155 (20130101) A61K 31/4184 (20130101) A61K 31/4245 (20130101) A61K 31/4545 (20130101) A61K 31/4709 (20130101) Acyclic or Carbocyclic Compounds C07C 69/738 (20130101) C07C 243/28 (20130101) C07C 311/21 (20130101) Heterocyclic Compounds C07D 209/08 (20130101) C07D 215/52 (20130101) C07D 215/56 (20130101) C07D 231/20 (20130101) C07D 235/18 (20130101) C07D 271/12 (20130101) C07D 275/03 (20130101) C07D 307/92 (20130101) C07D 401/04 (20130101) C07D 405/04 (20130101) C07D 405/14 (20130101) C07D 413/04 (20130101) C07D 471/04 (20130101) C07D 491/052 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Original (OR) Class
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10202711 — Tunable surface

US 10202711	Tuteja et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	Anish Tuteja (Cambridge, Massachusetts); Wonjae Choi (Cambridge, Massachusetts); Gareth H. McKinley (Acton, Massachusetts); Robert E. Cohen (Jamaica Plain, Massachusetts); Joseph Mark Mabry (Lancaster, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Anish Tuteja (Cambridge, Massachusetts); Wonjae Choi (Cambridge, Massachusetts); Gareth H. McKinley (Acton, Massachusetts); Robert E. Cohen (Jamaica Plain, Massachusetts); Joseph Mark Mabry (Lancaster, Massachusetts)
ABSTRACT	An article can have a surface with selected wetting properties for various liquids.
FILED	Monday, April 14, 2008
APPL NO	12/599465
ART UNIT	1783 — Miscellaneous Articles, Stock Material
CURRENT CPC	Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) Original (OR) Class Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/10 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 15/263 (20130101) D06M 23/08 (20130101) D06M 2200/05 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24355 (20150115) Y10T 428/24372 (20150115) Y10T 428/24612 (20150115) Y10T 428/31504 (20150401) Y10T 428/31663 (20150401) Y10T 428/249921 (20150401)
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10202857 — Vane stages

US 10202857	Simonds et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Systems Command (NAVAIR)
APPLICANT(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
ASSIGNEE(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Mark E. Simonds (Cape Neddick, Maine); Steven J. Feigleson (Falmouth, Maine)
ABSTRACT	A vane stage includes an arcuate platform defining a axial centerline axis having a pair of flanges that extend radially inward from the platform. The flanges are axially spaced from one another and from respective forward and aft ends of the platform. The vane stage includes a vane extending radially outward from the platform and a seal carrier mounted to the flanges of the platform. A method for constructing a vane stage includes sliding a seal carrier between flanges of an arcuate platform. Each flange includes at least a pair of through holes and interfaces with a respective axial side of the seal carrier. The method includes drilling through holes in each axial side of the seal carrier by using the through holes of each flange as guides.
FILED	Friday, February 06, 2015
APPL NO	14/616274
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/041 (20130101) Original (OR) Class F01D 11/001 (20130101) F01D 11/003 (20130101) F01D 25/005 (20130101) F01D 25/243 (20130101) F01D 25/246 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/10 (20130101) F05D 2230/60 (20130101) F05D 2240/12 (20130101) F05D 2240/55 (20130101) F05D 2240/80 (20130101) F05D 2300/133 (20130101) F05D 2300/603 (20130101)
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10203188 — Rotational control actuation system

US 10203188	Sowle et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Armament Research, Development and Engineering Center (ARDEC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Zak Sowle (Bellbrook, Ohio); Srikanth Vasudevan (Shelton, Connecticut); Matthew C. Birch (Madison, Alabama)
ASSIGNEE(S)	Orbital Research Inc (Cleveland, Ohio)
INVENTOR(S)	Zak Sowle (Bellbrook, Ohio); Srikanth Vasudevan (Shelton, Connecticut); Matthew C. Birch (Madison, Alabama)
ABSTRACT	A projectile incorporates one or more spoiler-tabbed spinning disks to effect flow around the projectile and thus impart steering forces and/or moments. The spoiler tabs may be deployed only during steering phases of travel thus minimizing the drag penalty associated with steering systems. The disks are driven by motors and informed and controlled by sensors and electronic control systems. The spoiler tabs protrude through the surface of the projectile only for certain angles of spin of the spinning disk. For spin-stabilized projectiles, the disks spin at substantially the same rate as the projectile, but the disks may function in fin-stabilized projectiles as well. Any number of such spinning flow effector disks may be incorporated in a projectile, with the manner of functional coordination differing slightly for even and odd numbers of disks.
FILED	Wednesday, February 28, 2018
APPL NO	15/907541
ART UNIT	3647 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 13/00 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 10/00 (20130101) F42B 10/26 (20130101) Original (OR) Class
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10203285 — Apparatus, methods, and systems for high-power and narrow-linewidth lasers

US 10203285	Redmond
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Shawn Redmond (Concord, Massachusetts)
ABSTRACT	A system includes a build-up cavity to locally increase the power of light beams within the build-up cavity, where the light beams interact with samples to sense a substance of interest. The build-up cavity is disposed within a main cavity that includes a gain material to amplify the light beams. A portion of the light beams oscillating in the build-up cavity propagators through the build-up cavity and functions as a feedback to control the linewidth of the light beams. The two cavities can function as two separate “filters” and light beams at wavelengths that propagate through both of these “filters” can be preferentially amplified. The combination of the build-up cavity and the main cavity can achieve high power and narrow linewidth for the light beams without complex electronics, thereby decreasing the size, weight, and power (SWaP) of the system.
FILED	Monday, December 12, 2016
APPL NO	15/375910
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Original (OR) Class G01N 2201/06113 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/02 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/30 (20130101) H01S 3/1306 (20130101) H01S 3/1628 (20130101) H01S 3/2316 (20130101) H01S 3/06791 (20130101) H01S 3/08013 (20130101)
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10203405 — Multitone radar with range determination and method of use

US 10203405	Mazzaro et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Gregory J. Mazzaro (Charleston, South Carolina); Kenneth I. Ranney (Rockville, Maryland); Kyle A. Gallagher (Derwood, Maryland); Anthony F. Martone (Ellicott City, Maryland)
ABSTRACT	Method for determining distance to target using a multitone nonlinear radar system comprising providing a transmitter that transmits a signal comprising at least two predetermined frequency components; receiving transmitted signal upon reflection from target; determining the phase relationships of the frequency components when signal strikes target; determining distance the signal has travelled to target based upon the phase relationship of the frequency signal components at the time of reflection from target; computing the distance to target. A system comprising a transmitter subsystem that transmits radar signal comprising at least two frequency components; a receiver subsystem configured to receive a return signal comprising intermodulation and harmonic products; at least one processor configured to extract frequency samples from the return signal within a frequency range, apply a window function to the extracted frequency samples and perform an inverse fast Fourier transform on the resulting function to create a range profile.
FILED	Friday, April 08, 2016
APPL NO	15/093788
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/292 (20130101) G01S 7/414 (20130101) G01S 13/103 (20130101) G01S 13/106 (20130101) Original (OR) Class G01S 13/887 (20130101)
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10203456 — Fiber optic cable to emitter/detector alignment apparatus and method

US 10203456	Krause
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Northrop Grumman Systems Corporation (Falls Church, Virginia)
ASSIGNEE(S)	Northrop Grumman Systems Corporation (Falls Church, Virginia)
INVENTOR(S)	Joseph P. Krause (Downers Grove, Illinois)
ABSTRACT	An apparatus for aligning a fiber optic connector with a detector or an emitter in a housing includes a stationary base mountable on the housing, a mobile stage movable relative to the stationary base, and spring-loaded adjustment screws on the stationary base oriented orthogonally relative to one another to adjust a position of the mobile stage in x and y directions. The stationary base and mobile stage include central openings that allow the adjustment mechanism to be positioned around the fiber optic connector. The stationary base and mobile stage also include lateral slots extending inwardly from their respective peripheral edges to their respective central openings to allow passage of a fiber optic cable when positioning or removing the apparatus.
FILED	Thursday, July 12, 2018
APPL NO	16/033250
ART UNIT	2874 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/3869 (20130101) G02B 6/3874 (20130101) Original (OR) Class G02B 6/4226 (20130101) G02B 7/003 (20130101)
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10203528 — Integrated polarization converter and frequency shifter

US 10203528	Yoo et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Sung-Joo Ben Yoo (Davis, California); Chuan Qin (Davis, California); Burcu Ercan (Davis, California); Hongbo Lu (Davis, California)
ABSTRACT	An optical device is described. This optical device includes an electro-optical material having an X-cut, Y-propagate orientation. In particular, a Y crystallographic direction of the electro-optical material is parallel to an optical waveguide defined in the electro-optic material and an X crystallographic direction of the electro-optical material is parallel to a vertical direction of the optical device. By applying drive signals having an angular frequency to the electro-optic material, the optical device may perform modulation, corresponding to a traveling-wave configuration, of an optical signal based at least in part on the drive signals. where the modulation involves a polarization conversion and a frequency shift. The angular frequency of the drive signals may be selected to approximately cancel electro-optic cross terms in X-Z plane of the electro-optical material. Moreover, an amplitude of the drive signals may be selected so that the optical device emulates a half-wave-plate configuration.
FILED	Wednesday, November 22, 2017
APPL NO	15/821600
ART UNIT	2874 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0327 (20130101) G02F 1/0353 (20130101) Original (OR) Class G02F 2201/127 (20130101) G02F 2203/07 (20130101)
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10203598 — Gradient spray coating polymer pen arrays

US 10203598	Mirkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); Keith A. Brown (Newton, Massachusetts); James L. Hedrick, III (Evanston, Illinois)
ABSTRACT	The disclosure provides a method of inking a polymer pen lithography tip array (“PPL tip array”), including applying an ink composition to a PPL tip array using at least two spray applicators to deposit the ink as a non-uniform ink layer. The disclosure further provides a method of depositing at least two ink compositions on PPL tip array, including applying a first ink to a first defined area using a first spray applicator, and applying a second ink to a second defined area using a second spray applicator. The disclosure further provides a method of scaling a linear ink composition gradient provided by at least two spray applicators to a PPL tip array having a length, L, including positioning the spray applicators at a distance of about 5.0 L to about 8.0 L relative to the surface of the PPL tip array, positioning the spray applicators at a distance of about 0.5 L to about 3.0 L relative to each other, and applying an ink composition.
FILED	Monday, October 17, 2016
APPL NO	15/295914
ART UNIT	1715 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 5/061 (20130101) B05D 2490/60 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class
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10203964 — Mobile device external controller module

US 10203964	Johnnie et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Darryn A. Johnnie (Waltham, Massachusetts); Andy D. Ngo (Waltham, Massachusetts); Stephen H. Kim (Waltham, Massachusetts)
ABSTRACT	An external controller module is configured for electrically coupling a mobile device to the one or more peripheral devices. The external controller module includes an interface port for coupling to a communication port of the mobile device and a number of interface ports for coupling the external controller module to respective peripheral devices. The controller module operating system includes device driver program code for facilitating electrical communication between the peripheral device and the mobile device without installing the device driver program code on the mobile device.
FILED	Friday, August 25, 2017
APPL NO	15/686744
ART UNIT	2185 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 8/65 (20130101) G06F 9/4411 (20130101) Original (OR) Class G06F 13/385 (20130101) G06F 13/4282 (20130101) G06F 2213/0042 (20130101) G06F 2213/3812 (20130101) G06F 2213/4004 (20130101)
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10203996 — Filtering system noises in parallel computer system during thread synchronization

US 10203996	Yim et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Keun Soo Yim (Sunnyvale, California); Seetharami R. Seelam (Yorktown Heights, New York); Liana L. Fong (Irvington, New York); Arun Iyengar (Yorktown Heights, New York); John Lewars (Poughkeepsie, New York)
ABSTRACT	Various embodiments monitor system noise in a parallel computing system. In one embodiment, at least one set of system noise data is stored in a shared buffer during a first computation interval. The set of system noise data is detected during the first computation interval and is associated with at least one parallel thread in a plurality of parallel threads. Each thread in the plurality of parallel threads is a thread of a program. The set of system noise data is filtered during a second computation interval based on at least one filtering condition creating a filtered set of system noise data. The filtered set of system noise data is then stored.
FILED	Friday, December 16, 2016
APPL NO	15/381208
ART UNIT	2195 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 9/522 (20130101) Original (OR) Class G06F 9/4881 (20130101) G06F 11/3024 (20130101) G06F 11/3072 (20130101) G06F 11/3404 (20130101) G06F 11/3409 (20130101) G06F 11/3419 (20130101) G06F 11/3476 (20130101) G06F 2201/88 (20130101) G06F 2201/815 (20130101)
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10204118 — Mapping neural dynamics of a neural model on to a coarsely grained look-up table

US 10204118	Alvarez-Icaza Rivera et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Rodrigo Alvarez-Icaza Rivera (San Jose, California); John V. Arthur (Mountain View, California); Andrew S. Cassidy (San Jose, California); Pallab Datta (San Jose, California); Paul A. Merolla (Palo Alto, California); Dharmendra S. Modha (San Jose, California)
ABSTRACT	Embodiments of the invention relate to mapping neural dynamics of a neural model on to a lookup table. One embodiment comprises defining a phase plane for a neural model. The phase plane represents neural dynamics of the neural model. The phase plane is coarsely sampled to obtain state transition information for multiple neuronal states. The state transition information is mapped on to a lookup table.
FILED	Wednesday, June 29, 2016
APPL NO	15/197599
ART UNIT	2129 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 17/10 (20130101) G06F 17/30292 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/049 (20130101) G06N 3/063 (20130101)
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10204291 — System, method, and recording medium for detecting events for interest from mobile

US 10204291	Lin et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Chung-Ching Lin (White Plains, New York); Sharathchandra U. Pankanti (Darien, Connecticut); John R. Smith (New York, New York)
ABSTRACT	A discrepancy detection system for detecting a discrepancy between a plurality of video images of a same scene captured by an imaging device at different times, the system including a correspondence point detection device configured to detect corresponding points matching each other between a first video image sequence of the plurality of video images and a second video image sequence of the plurality of video images and a comparison device configured to compare image content of the first video image sequence and the second video image sequence for the discrepancy in the image content between the first video image sequence and the second video image sequence.
FILED	Monday, August 31, 2015
APPL NO	14/840293
ART UNIT	2486 — Recording and Compression
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/629 (20130101) Original (OR) Class G06K 9/00758 (20130101) G06K 9/6215 (20130101) Pictorial Communication, e.g Television H04N 5/262 (20130101) H04N 5/23238 (20130101)
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10204301 — Implementing a neural network algorithm on a neurosynaptic substrate based on criteria related to the neurosynaptic substrate

US 10204301	Amir et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Arnon Amir (Saratoga, California); Rathinakumar Appuswamy (San Jose, California); Pallab Datta (San Jose, California); Myron D. Flickner (San Jose, California); Paul A. Merolla (Palo Alto, California); Dharmendra S. Modha (San Jose, California); Benjamin G. Shaw (San Francisco, California)
ABSTRACT	One embodiment of the invention provides a system for mapping a neural network onto a neurosynaptic substrate. The system comprises a reordering unit for reordering at least one dimension of an adjacency matrix representation of the neural network. The system further comprises a mapping unit for selecting a mapping method suitable for mapping at least one portion of the matrix representation onto the substrate, and mapping the at least one portion of the matrix representation onto the substrate utilizing the mapping method selected. The system further comprises a refinement unit for receiving user input regarding at least one criterion relating to accuracy or resource utilization of the substrate. The system further comprises an evaluating unit for evaluating each mapped portion against each criterion. Each mapped portion that fails to satisfy a criterion may be remapped to allow trades offs between accuracy and resource utilization of the substrate.
FILED	Wednesday, March 18, 2015
APPL NO	14/662096
ART UNIT	2129 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/063 (20130101) Original (OR) Class
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10204620 — Adjusting a deep neural network acoustic model

US 10204620	Cui et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Xiaodong Cui (Chappaqua, New York); Vaibhava Goel (Chappaqua, New York)
ABSTRACT	A computer-implemented method according to one embodiment includes estimating a speaker dependent acoustic model utilizing test speech data and maximum likelihood linear regression (MLLR), transforming labeled speech data to create transformed speech data, utilizing the speaker dependent acoustic model and a linear transformation, and adjusting a deep neural network (DNN) acoustic model, utilizing the transformed speech data.
FILED	Wednesday, September 07, 2016
APPL NO	15/258799
ART UNIT	2658 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/07 (20130101) G10L 15/16 (20130101) Original (OR) Class G10L 15/063 (20130101) G10L 15/075 (20130101) G10L 17/18 (20130101)
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10204621 — Adjusting a deep neural network acoustic model

US 10204621	Cui et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Xiaodong Cui (Chappaqua, New York); Vaibhava Goel (Chappaqua, New York)
ABSTRACT	A computer-implemented method according to one embodiment includes estimating a speaker dependent acoustic model utilizing test speech data and a hybrid estimation technique, transforming labeled speech data to create transformed speech data, utilizing the speaker dependent acoustic model and a nonlinear transformation, and adjusting a deep neural network (DNN) acoustic model, utilizing the transformed speech data.
FILED	Wednesday, September 07, 2016
APPL NO	15/258836
ART UNIT	2658 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/07 (20130101) G10L 15/16 (20130101) Original (OR) Class G10L 15/063 (20130101) G10L 15/075 (20130101) G10L 17/18 (20130101)
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10204864 — Stretchable form of single crystal silicon for high performance electronics on rubber substrates

US 10204864	Rogers et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Macroelectronics Program (AFRL/MACRO) Defense Advanced Research Projects Agency (DARPA) Department of Energy (DOE) Office of Science (DOE-SC) Materials Sciences and Engineering Division (MSE)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	John A. Rogers (Champaign, Illinois); Dahl-Young Khang (Seoul, South Korea); Yugang Sun (Naperville, Illinois); Etienne Menard (Durham, North Carolina)
ABSTRACT	The present invention provides stretchable, and optionally printable, semiconductors and electronic circuits capable of providing good performance when stretched, compressed, flexed or otherwise deformed. Stretchable semiconductors and electronic circuits of the present invention preferred for some applications are flexible, in addition to being stretchable, and thus are capable of significant elongation, flexing, bending or other deformation along one or more axes. Further, stretchable semiconductors and electronic circuits of the present invention may be adapted to a wide range of device configurations to provide fully flexible electronic and optoelectronic devices.
FILED	Monday, October 31, 2016
APPL NO	15/339338
ART UNIT	2895 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/564 (20130101) H01L 23/3157 (20130101) H01L 23/5387 (20130101) Original (OR) Class H01L 29/78603 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0283 (20130101)
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10204875 — Systems and methods for inhibiting backend access to integrated circuits by integrating photon and electron sensing latch-up circuits

US 10204875	Kay et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Surface Warfare Center (NSWC)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Matthew Kay (Jasper, Indiana); Matthew Gadlage (Bloomington, Indiana); Adam Duncan (Bloomington, Indiana); Brett Hamilton (Heltonville, Indiana); Brett Werner (Jasper, Indiana); Austin Roach (Bloomfield, Indiana)
ABSTRACT	Exemplary systems and methods for inhibiting backend access to an integrated circuit are provided including latch-up circuits triggered by photons, electrons, and ions to create catastrophic failures in integrated circuits. Exemplary systems include latch-up circuits with floating gate bit cells which, when triggered, close the latch-up circuits so that the latch-up circuits can amplify current in a positive feedback loop to create a short circuit to inhibit unauthorized individuals from probing or modifying an integrated circuit.
FILED	Thursday, April 12, 2018
APPL NO	15/951576
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/576 (20130101) Original (OR) Class
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10205302 — Quantum dot SOA-silicon external cavity multi-wavelength laser

US 10205302	Zhang et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	Elenion Technologies, LLC (, None)
ASSIGNEE(S)	Elenion Technologies, LLC (New York, New York)
INVENTOR(S)	Yi Zhang (Jersey City, New Jersey); Shuyu Yang (Jersey City, New Jersey); Michael J. Hochberg (New York, New York); Thomas Wetteland Baehr-Jones (Arcadia, California)
ABSTRACT	A hybrid external cavity multi-wavelength laser using a QD RSOA and a silicon photonics chip is demonstrated. Four lasing modes at 2 nm spacing and less than 3 dB power non-uniformity were observed, with over 20 mW of total output power. Each lasing peak can be successfully modulated at 10 Gb/s. At 10⁻⁹BER, the receiver power penalty is less than 2.6 dB compared to a conventional commercial laser. An expected application is the provision of a comb laser source for WDM transmission in optical interconnection systems.
FILED	Friday, November 03, 2017
APPL NO	15/802812
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/005 (20130101) H01S 3/0078 (20130101) H01S 5/14 (20130101) H01S 5/021 (20130101) H01S 5/141 (20130101) Original (OR) Class H01S 5/142 (20130101) H01S 5/146 (20130101) H01S 5/343 (20130101) H01S 5/1032 (20130101) H01S 5/1096 (20130101) H01S 5/3412 (20130101) H01S 5/4062 (20130101) H01S 5/06804 (20130101)
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10205454 — Glitch free asynchronous clock multiplexer

US 10205454	Lapiana
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	GOVERMENT OF THE UNITED STATES AS REPRESENTED BY TE SECRETARY OF THE AIR FORCE (Rome, New York)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia)
INVENTOR(S)	Giuseppe A. Lapiana (Liverpool, New York)
ABSTRACT	Apparatus for glitch-free switching between multiple asynchronous clock sources on an integrated circuit. Clock gaters provide a clock from a single source that can be turned on and off without causing partial pulses to be created. Control circuitry going to the individual clock gaters is synchronized to the destination clock domain and provides the ability to shut all clocks off for a period of time equal to the longest clock period. By combining the clocks with an OR gate and gating all clocks off before switching from one clock to another, a glitch-free train of clock pulses can be created from individual clock inputs. Since clock glitches can cause erratic behavior in integrated circuits, this invention allows one to switch between different, asynchronous clocks without causing erratic behavior.
FILED	Tuesday, November 22, 2016
APPL NO	15/358642
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Pulse Technique H03K 5/135 (20130101) H03K 19/00346 (20130101) Original (OR) Class H03K 2005/00234 (20130101)
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10205473 — Cartesian error-feedback transmitter architecture with a feedforward path

US 10205473	Gu et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Qun Gu (Davis, California); Jinbo Li (Davis, California)
ABSTRACT	An error-feedback transmitter includes an input that receives an input signal, and an output that produces an output signal. It also includes an amplifier, located on a main path that carries a main signal between the input and the output. The transmitter includes a feedback path that carries a feedback signal from the output to the input, and a feedback-signal combiner, located on the main path between the input and the amplifier. The feedback-signal combiner negatively combines the feedback signal with the input signal to improve linearity in the output signal. The transmitter includes a feedforward path that carries a feedforward signal from the input toward the output, and a feedforward-signal combiner, located on the feedback path between the output and the feedback-signal combiner. The feedforward-signal combiner negatively combines the feedforward signal with the feedback signal to suppress components of the main signal in the feedback signal.
FILED	Thursday, November 30, 2017
APPL NO	15/828031
ART UNIT	2632 — Digital Communications
CURRENT CPC	Transmission H04B 1/40 (20130101) H04B 1/0475 (20130101) Original (OR) Class H04B 2001/0433 (20130101) H04B 2001/0441 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/366 (20130101) H04L 27/2615 (20130101) H04L 27/3411 (20130101)
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10205521 — Network of extremely high burst rate optical downlinks

US 10205521	Boroson et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Don M. Boroson (Needham, Massachusetts); Bryan Shawn Robinson (Arlington, Massachusetts); Bryan M. Reid (Chelmsford, Massachusetts)
ABSTRACT	Traditional satellite-to-earth data transmission systems are constrained by inefficient relay schemes and/or short-duration data transfers at low data rates. Communication systems described herein achieve extremely high burst rate (e.g., 10 Gbps or greater) direct-to-Earth (DTE) data transmission over a free-space optical link between a spacecraft and a remote terminal, which may be a ground terminal or another space terminal. The optical link is established, for example, when the remote terminal is at an elevation of 20° with respect to a horizon of the remote terminal. In some embodiments, a data transmission burst contains at least 1 Terabyte of information, and has a duration of 6 minutes or less. The communication system can include forward error correction by detecting a degradation of a received free-space optical signal and re-transmitting at least a portion of the free-space optical signal.
FILED	Friday, January 08, 2016
APPL NO	14/991394
ART UNIT	2636 — Optical Communications
CURRENT CPC	Transmission H04B 7/18513 (20130101) H04B 10/29 (20130101) H04B 10/40 (20130101) H04B 10/61 (20130101) H04B 10/118 (20130101) Original (OR) Class H04B 10/1121 (20130101) Multiplex Communication H04J 14/02 (20130101)
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10205550 — Scalable, low-latency medium-access control technique for optically switched networks

US 10205550	Muller et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Oracle International Corporation (Redwood Shores, California)
ASSIGNEE(S)	Oracle International Corporation (Redwood Shores, California)
INVENTOR(S)	Shimon Muller (Sunnyvale, California); Ashok V. Krishnamoorthy (San Diego, California); Leick D. Robinson (Austin, Texas); Xuezhe Zheng (San Diego, California)
ABSTRACT	An optically switched network system includes an optical switch with N inputs and N outputs that connects N end-nodes and is structured to transmit N wavelengths from each of the N inputs to each of the N outputs. The system includes a virtual data plane and a virtual control plane, which both communicate through the optical switch. The virtual data plane provides any-to-all parallel connectivity for data transmissions among the N end-nodes. The N end-nodes are partitioned into two or more subsets, wherein end-nodes in a given source subset transmit data to a given destination subset using wavelengths, which are not used by end-nodes outside of the given source subset to transmit data to the same given destination subset. The virtual control plane includes two or more rings associated with the two or more subsets of end-nodes. Each ring passes through a subset of end-nodes, and is used to communicate arbitration information among arbitration logic located at each end-node in the ring.
FILED	Tuesday, April 04, 2017
APPL NO	15/478909
ART UNIT	2636 — Optical Communications
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/356 (20130101) G02B 6/1225 (20130101) G02B 6/3546 (20130101) G02B 6/29382 (20130101) Multiplex Communication H04J 14/0212 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 49/15 (20130101) Selecting H04Q 11/0005 (20130101)
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10205740 — Cyber-semantic account management system

US 10205740	Stirtzinger et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Securboration, Inc. (Melbourne, Florida)
ASSIGNEE(S)	Securboration, Inc. (Melbourne, Florida)
INVENTOR(S)	Anthony Stirtzinger (Ponte Vedra Beach, Florida); Keith Shapiro (Saint Louis, Missouri); Brian Warhover (Fairview Heights, Illinois); Bruce McQueary (Indialantic, Florida)
ABSTRACT	Systems, methods, and apparatus for identifying anomalous behavior are provided. For example, a method may include receiving raw data, generating a behavior profile for the entity based on the raw data, receiving comparison data, determining whether the comparison data deviates from a pattern of behavior defined in the behavior profile, and identifying the comparison data as anomalous behavior when the comparison data deviates from the pattern of behavior. In one embodiment, the raw data includes recorded activity for the entity. In one embodiment, the behavior profile defines a pattern of behavior for the entity. In one embodiment, a countermeasure is performed upon identifying anomalous behavior. The countermeasure may include at least one of revoking the entity's credentials, denying the entity access to a resource, shutting down access to a port, and denying access to the entity. The method may further include providing a report of the anomalous behavior.
FILED	Tuesday, May 16, 2017
APPL NO	15/596515
ART UNIT	2498 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1408 (20130101) H04L 63/1441 (20130101) Original (OR) Class Wireless Communication Networks H04W 12/12 (20130101)
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Department of Energy (DOE)

10201803 — Polymer-metal organic framework materials and methods of using the same

US 10201803	Cohen et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Seth M. Cohen (Carlsbad, California); Zhenjie Zhang (San Diego, California)
ABSTRACT	Disclosed herein, inter alia, are polymerized metal organic framework compositions and polymer compositions, and methods of making and using the same.
FILED	Thursday, June 09, 2016
APPL NO	15/178498
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Separation B01D 53/02 (20130101) B01D 53/04 (20130101) B01D 2253/204 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/262 (20130101) Original (OR) Class Non-metallic Elements; Compounds Thereof; C01B 32/50 (20170801) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 83/001 (20130101) Capture, Storage, Sequestration or Disposal of Greenhouse Gases [GHG] Y02C 10/08 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/152 (20151101)
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10201877 — Puddle forming and shaping with primary and secondary lasers

US 10201877	Haake
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Titanova Inc (St. Charles, Missouri)
ASSIGNEE(S)
INVENTOR(S)	John M. Haake (St. Charles, Missouri)
ABSTRACT	A material processing system for a base material is provided. The system includes a feeder having a distal end proximate to a surface location of the base material. The feeder supplies a deposit material to the surface location. The deposit material has a width having a first side and a second side. A first laser is directed to the deposit material at the surface location. The first laser is directed across the width from the first side to the second side. A second laser is directed to a desired location within the width. A control system drives the process of cladding the deposit material. The control system includes a shape controller to control the movement of the secondary laser along the deposit material based on feedback from a sensor.
FILED	Friday, October 26, 2012
APPL NO	13/661113
ART UNIT	3761 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/32 (20130101) Original (OR) Class B23K 26/34 (20130101) B23K 26/144 (20151001) B23K 26/342 (20151001) B23K 35/0244 (20130101) B23K 2103/50 (20180801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201)
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10202292 — System and method of water purification utilizing an ionomer membrane

US 10202292	Bahar et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Bamdad Bahar (Georgetown, Delaware); Luyu Jin (Harbeson, Delaware); William Parmelee (Seaford, Delaware); Jacob Zerby (Harbeson, Delaware)
ASSIGNEE(S)	Xergy LTD (, United Kingdom)
INVENTOR(S)	Bamdad Bahar (Georgetown, Delaware); Luyu Jin (Harbeson, Delaware); William Parmelee (Seaford, Delaware); Jacob Zerby (Harbeson, Delaware)
ABSTRACT	A water purification system utilizes an ionomer membrane and mild vacuum to draw water from source water through the membrane. A water source may be salt water or a contaminated water source. The water drawn through the membrane passes across the condenser chamber to a condenser surface where it is condensed into purified water. The condenser surface may be metal or any other suitable surface and may be flat or pleated. In addition, the condenser surface may be maintained at a lower temperature than the water on the water source side of the membrane. The ionomer membrane may be configured in a cartridge, a pleated or flat plate configuration. A latent heat loop may be configured to carry the latent heat of vaporization from the condenser back to the water source side of the ionomer membrane. The source water may be heated by a solar water heater.
FILED	Thursday, October 20, 2016
APPL NO	15/299110
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 61/364 (20130101) B01D 61/366 (20130101) B01D 61/368 (20130101) B01D 69/12 (20130101) B01D 71/32 (20130101) B01D 2313/22 (20130101) B01D 2313/24 (20130101) B01D 2325/34 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/14 (20130101) C02F 1/32 (20130101) C02F 1/78 (20130101) C02F 1/283 (20130101) C02F 1/447 (20130101) Original (OR) Class C02F 2103/08 (20130101)
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10202428 — Compositions and methods for the delivery of oxygen

US 10202428	Cary et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Stephen P. L. Cary (San Mateo, California); Elizabeth M. Boon (Stony Brook, New York); Emily Weinert (Berkeley, California); Jonathan A. Winger (Oakland, California); Michael A. Marletta (La Jolla, California)
ABSTRACT	H—NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O₂delivery. The engineered H—NOX proteins comprise mutations that impart altered O₂or NO ligand-binding relative to the corresponding wild-type H—NOX domain, and are operative as physiologically compatible mammalian blood O₂gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H—NOX proteins for the treatment of any condition for which delivery of O₂is beneficial.
FILED	Wednesday, October 12, 2016
APPL NO	15/292012
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/33 (20130101) C07K 14/47 (20130101) Original (OR) Class C07K 14/195 (20130101) C07K 14/435 (20130101) C07K 14/43545 (20130101) C07K 14/43563 (20130101) C07K 14/43581 (20130101) Technologies for Adaptation to Climate Change Y02A 50/469 (20180101) Y02A 50/471 (20180101) Y02A 50/478 (20180101) Technical Subjects Covered by Former US Classification Y10T 436/102499 (20150115)
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10202567 — Bioreactors including enzyme-embedded multicomponent polymers

US 10202567	Stolaroff et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
INVENTOR(S)	Joshuah K. Stolaroff (Oakland, California); Roger Aines (Livermore, California); Sarah Baker (Dublin, California); Craig D. Blanchette (Concord, California); Amitesh Maiti (San Ramon, California); John Vericella (Oakland, California); James S. Oakdale (Castro Valley, California)
ABSTRACT	According to one general embodiment, a membrane, includes a polymeric network configured to separate a first fluid and a second fluid, where the first and second fluids are different; and a plurality of enzymatic reactive components embedded within the polymeric network. According to another embodiment, a bioreactor includes a lattice of three dimensional structures, each structure including a membrane having: a polymeric network configured to separate a first fluid and a second fluid, where the first and second fluids are different; and a plurality of enzymatic reactive components embedded within the polymeric network.
FILED	Thursday, January 21, 2016
APPL NO	15/003257
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/00 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 21/18 (20130101) Original (OR) Class C12M 23/24 (20130101) C12M 45/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) C12N 11/08 (20130101)
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10202592 — Polypeptides having xylanase activity and polynucleotides encoding same

US 10202592	Vlasenko et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Novozymes, Inc. (Davis, California); Novozymes A/S (Bagsvaerd, Denmark)
ASSIGNEE(S)	Novozymes A/S (Bagsvaerd, Denmark); Novozymes, Inc. (Davis, California)
INVENTOR(S)	Elena Vlasenko (Davis, California); Brett McBrayer (Sacramento, California); Dominique Skovlund (Vaerloese, Denmark); Sara Landvik (Vedbaek, Denmark)
ABSTRACT	The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
FILED	Tuesday, December 13, 2016
APPL NO	15/377206
ART UNIT	1662 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2434 (20130101) Original (OR) Class C12N 9/2462 (20130101) Enzymes C12Y 302/01008 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/16 (20130101) Y02E 50/17 (20130101)
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10202614 — Digestibility of plant biomass

US 10202614	Brandizzi et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Ohio University (Athens, Ohio); Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S)	Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S)	Federica Brandizzi (East Lansing, Michigan); Curtis Wilkerson (Swartz Creek, Michigan); Sang Jin Kim (Okemos, Michigan); Michael Held (Athens, Ohio)
ABSTRACT	Plants described herein have increased biomass and are more readily digested into fermentable sugars when the plants express increased levels of one or more types of CGR2 and/or CGR3 enzymes.
FILED	Friday, June 27, 2014
APPL NO	14/901904
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1007 (20130101) C12N 15/8261 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) C12P 19/14 (20130101) Enzymes C12Y 201/01 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101)
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10202628 — Assembly of nucleic acid sequences in emulsions

US 10202628	Church et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	George M. Church (Brookline, Massachusetts); Richard C. Terry (Carlisle, Massachusetts); Sriram Kosuri (Cambridge, Massachusetts); Di Zhang (Boston, Massachusetts)
ABSTRACT	Methods and compositions for synthesizing nucleic acid sequences in an emulsion are provided.
FILED	Thursday, February 14, 2013
APPL NO	14/379005
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1031 (20130101) C12N 15/1031 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) C12Q 1/6851 (20130101) C12Q 2521/313 (20130101) C12Q 2521/313 (20130101) C12Q 2525/131 (20130101) C12Q 2525/131 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/159 (20130101) C12Q 2563/159 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101)
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10202660 — Methods for increasing sugar yield with size-adjusted lignocellulosic biomass particles

US 10202660	Balan et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan)
ASSIGNEE(S)	BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan)
INVENTOR(S)	Venkatesh Balan (East Lansing, Michigan); Bruce E. Dale (Mason, Michigan); Shuhaida Harun (Senawang, Malaysia)
ABSTRACT	A method of increasing sugar yield in a bioproduct production process is provided comprising pretreating one or more size-adjusted lignocellulosic biomass (LCB) particles with a pretreatment, such as an ammonia pretreatment, wherein the one or more size-adjusted LCB particles form a substrate, with the one or more particles having an average particle size in at least one dimension greater than 5 mm.
FILED	Friday, March 01, 2013
APPL NO	14/382370
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Fodder A23K 10/30 (20160501) A23K 10/32 (20160501) A23K 10/37 (20160501) A23K 20/111 (20160501) Acyclic or Carbocyclic Compounds C07C 31/08 (20130101) C07C 31/10 (20130101) Derivatives of Natural Macromolecular Compounds C08H 8/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/18 (20130101) C12M 45/02 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) C12P 7/16 (20130101) C12P 19/02 (20130101) C12P 19/14 (20130101) C12P 2201/00 (20130101) Saccharides Obtained From Natural Sources or by Hydrolysis of Naturally Occurring Disaccharides, Oligosaccharides or Polysaccharides C13K 1/02 (20130101) Original (OR) Class C13K 13/002 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) Y02E 50/16 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 60/877 (20151101)
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10202927 — Fueling strategy for controlled-autoignition engines

US 10202927	Jade et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Robert Bosch GmbH (Stuttgart, Germany)
ASSIGNEE(S)	Robert Bosch GmbH (Stuttgart, Germany); The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Shyam Jade (Ann Arbor, Michigan); Erik Hellstrom (Ann Arbor, Michigan); Anna Stefanopoulou (Ann Arbor, Michigan); Li Jiang (Ann Arbor, Michigan)
ABSTRACT	Methods and systems for controlling combustion performance of an engine during recompression HCCI combustion are provided. The method includes regulating a valve actuation timing and a fuel injection timing to cause a combustion phasing of at least one cylinder of the engine to approach a target combustion phasing, and estimating current combustion state information based on the combustion phasing. The current combustion state information includes at least one of a temperature, a pressure, and a pre-combustion charge composition associated with the at least one cylinder. The method further includes determining a target fuel injection amount, and determining whether the target fuel injection amount would require actuator settings that violate predetermined constraints in order to cause the combustion phasing to approach the target combustion phasing. A fuel injection amount is adjusted when the target fuel injection amount would require actuator settings that violate the predetermined constraints.
FILED	Monday, September 17, 2012
APPL NO	13/621433
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Controlling Combustion Engines F02D 35/023 (20130101) F02D 35/028 (20130101) F02D 41/40 (20130101) F02D 41/2451 (20130101) Original (OR) Class F02D 41/2464 (20130101) F02D 41/3035 (20130101) F02D 2041/141 (20130101) F02D 2041/1412 (20130101) F02D 2041/1416 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/44 (20130101) Y02T 10/128 (20130101)
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10202929 — Additive-mixing fuel-injection system for internal combustion engines

US 10202929	Dec et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	John E. Dec (Livermore, California); Ronald F. Renzi (Tracy, California)
ABSTRACT	A system and method for fast control of the timing of combustion in an internal combustion engine, comprising actuating a fast-acting fuel-additive supply valve to meter a variable amount of fuel additive into a fuel stream, thereby forming an additive-enhanced fuel with an additive concentration that can be dynamically adjusted as fast as each engine cycle; injecting the additive-enhanced fuel directly or indirectly into a combustion chamber or into an intake port; and combusting the additive-enhanced fuel.
FILED	Wednesday, September 16, 2015
APPL NO	14/855809
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Controlling Combustion Engines F02D 19/12 (20130101) F02D 41/26 (20130101) F02D 41/401 (20130101) Original (OR) Class Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 35/10216 (20130101) F02M 51/0603 (20130101)
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10203164 — Solar thermoelectricity via advanced latent heat storage

US 10203164	Olsen et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado); Colorado School of Mines (Golden, Colorado); Nathan P. Siegel (Lewisburg, Pennsylvania)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S)	Michele L. Olsen (Arvada, Colorado); Eric S. Toberer (Golden, Colorado); David Samuel Ginley (Evergreen, Colorado); Philip A. Parilla (Lakewood, Colorado); Emily L. Warren (Golden, Colorado); Aaron Daniel Martinez (Arvada, Colorado); Jonathan E. Rea (Lakewood, Colorado); Corey Lee Hardin (Cupertino, California); Christopher J. Oshman (Golden, Colorado); Nathan P. Siegel (Lewisburg, Pennsylvania)
ABSTRACT	An aspect of the present disclosure is a system that includes a thermal valve having a first position and a second position, a heat transfer fluid, and an energy converter where, when in the first position, the thermal valve prevents the transfer of heat from the heat transfer fluid to the energy converter, and when in the second position, the thermal valve allows the transfer of heat from the heat transfer fluid to the energy converter, such that at least a portion of the heat transferred is converted to electricity by the energy converter.
FILED	Tuesday, October 11, 2016
APPL NO	15/290051
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Producing or Use of Heat Not Otherwise Provided For F24J 2/07 (20130101) F24J 2/34 (20130101) F24J 2/4649 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 20/20 (20180501) F24S 60/00 (20180501) F24S 80/20 (20180501) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/06 (20130101) F28D 20/021 (20130101) Original (OR) Class F28D 20/028 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2013/005 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/30 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/41 (20130101) Y02E 60/145 (20130101) Y02E 70/30 (20130101)
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10203307 — Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging

US 10203307	Wang et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Daojing Wang (Moraga, California); Pan Mao (Fremont, California); Rafael Gomez-Sjoberg (Menlo Park, California); Hung-Ta Wang (Tuscaloosa, Alabama); Peidong Yang (Kensington, California)
ABSTRACT	Systems, methods, and apparatus provide integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end of the first channel is proximate the emitter.
FILED	Wednesday, June 03, 2015
APPL NO	14/729999
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 2300/069 (20130101) B01L 2300/0803 (20130101) B01L 2300/0816 (20130101) B01L 2300/0861 (20130101) B01L 2300/0867 (20130101) B01L 2300/0887 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/06 (20130101) Original (OR) Class G01N 30/6095 (20130101) G01N 30/7233 (20130101) G01N 30/7266 (20130101) G01N 2030/8813 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0431 (20130101)
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10204168 — Systems and methods for automatically identifying and linking names in digital resources

US 10204168	Parker et al.
FUNDED BY	Department of Energy (DOE) Small Business Administration (SBA) Small Business Technology Transfer (STTR)
APPLICANT(S)	NAMESFORLIFE, LLC (East Lansing, Michigan)
ASSIGNEE(S)	NAMESFORLIFE, LLC (East Lansing, Michigan)
INVENTOR(S)	Charles T. Parker (East Lansing, Michigan); Catherine M. Lyons (Edinburgh, United Kingdom); Gerald P. Roston (Saline, Michigan); George M. Garrity (Okemos, Michigan)
ABSTRACT	The present invention provides systems and methods for automatically identifying name-like-strings in digital resources, matching these name-like-string against a set of names held in an expertly curated database, and for those name-like-strings found in said database, enhancing the content by associating additional matter with the name, wherein said matter includes information about the names that is held within said database and pointers to other digital resources which include the same name and it synonyms.
FILED	Tuesday, June 06, 2017
APPL NO	15/615171
ART UNIT	2162 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 17/30864 (20130101) G06F 17/30887 (20130101) Original (OR) Class
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10204864 — Stretchable form of single crystal silicon for high performance electronics on rubber substrates

US 10204864	Rogers et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Macroelectronics Program (AFRL/MACRO) Defense Advanced Research Projects Agency (DARPA) Department of Energy (DOE) Office of Science (DOE-SC) Materials Sciences and Engineering Division (MSE)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	John A. Rogers (Champaign, Illinois); Dahl-Young Khang (Seoul, South Korea); Yugang Sun (Naperville, Illinois); Etienne Menard (Durham, North Carolina)
ABSTRACT	The present invention provides stretchable, and optionally printable, semiconductors and electronic circuits capable of providing good performance when stretched, compressed, flexed or otherwise deformed. Stretchable semiconductors and electronic circuits of the present invention preferred for some applications are flexible, in addition to being stretchable, and thus are capable of significant elongation, flexing, bending or other deformation along one or more axes. Further, stretchable semiconductors and electronic circuits of the present invention may be adapted to a wide range of device configurations to provide fully flexible electronic and optoelectronic devices.
FILED	Monday, October 31, 2016
APPL NO	15/339338
ART UNIT	2895 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/564 (20130101) H01L 23/3157 (20130101) H01L 23/5387 (20130101) Original (OR) Class H01L 29/78603 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0283 (20130101)
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10205195 — Alkali metal ion battery with bimetallic electrode

US 10205195	Boysen et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Dane A. Boysen (Pasadena, California); David J. Bradwell (Arlington, Massachusetts); Kai Jiang (Malden, Massachusetts); Hojong Kim (State College, Pennsylvania); Luis A. Ortiz (Natick, Massachusetts); Donald R. Sadoway (Cambridge, Massachusetts); Alina A. Tomaszowska (Bienkowice, Poland); Weifeng Wei (Hunan, China PRC); Kangli Wang (Malden, Massachusetts)
ABSTRACT	Electrochemical cells having molten electrodes having an alkali metal provide receipt and delivery of power by transporting atoms of the alkali metal between electrode environments of disparate chemical potentials through an electrochemical pathway comprising a salt of the alkali metal. The chemical potential of the alkali metal is decreased when combined with one or more non-alkali metals, thus producing a voltage between an electrode comprising the molten alkali metal and the electrode comprising the combined alkali/non-alkali metals.
FILED	Friday, April 03, 2015
APPL NO	14/678602
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/40 (20130101) H01M 4/364 (20130101) H01M 4/381 (20130101) H01M 10/39 (20130101) Original (OR) Class H01M 10/399 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0042 (20130101) H02J 7/0052 (20130101)
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10205322 — Economically efficient operation of a power generator

US 10205322	Keene et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Cummins Power Generation IP, Inc. (Minneapolis, Minnesota)
ASSIGNEE(S)	Cummins Power Generation IP, Inc. (Minneapolis, Minnesota)
INVENTOR(S)	Kevin Keene (Coon Rapids, Minnesota); Benjamin S. Fuchs (Andover, Minnesota); Michelle Hunt (Minneapolis, Minnesota)
ABSTRACT	A method of operating a power generator comprises receiving, a fault code corresponding to an operating condition of the power generator being outside of an acceptable range. A generator controller determines a cost of increased maintenance or repairing damage associated with overriding the fault code and maintaining existing power output from the power generator through the operating condition. A cost of a utility fine or contractual penalty associated with shutting down the power generator is determined in response to the fault code. The generator controller compares the cost of the utility fine or contractual penalty associated with shutting down the power generator with the cost of increased maintenance or damage repair to the power generator associated with overriding the fault code and maintaining existing power output through the operating condition. In response to the comparing, the fault code is overridden continuing operation of the power generator.
FILED	Tuesday, March 08, 2016
APPL NO	15/064197
ART UNIT	2827 — Semiconductors/Memory
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/381 (20130101) Original (OR) Class
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10205399 — Switching strategy for increased efficiency of power converters

US 10205399	Dong et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	GENERAL ELECTRIC COMPANY (Schenectady, Vanuatu)
INVENTOR(S)	Dong Dong (Schenectady, New York); Robert Gregory Wagoner (Roanoke, Virginia); Govardhan Ganireddy (Bangalore, India); Ravisekhar Nadimpalli Raju (Clifton Park, New York)
ABSTRACT	Systems and methods for operating a power converter are provided. A DC to AC converter can include an inner converter and an outer converter. The inner converter can include an isolation transformer a first plurality of switching devices. The outer converter can include a second plurality of switching devices. A control method can include determining an output voltage of the outer converter. The control method can further include controlling operation of the inner converter based at least in part on the output voltage of the outer converter.
FILED	Friday, January 13, 2017
APPL NO	15/405712
ART UNIT	2838 — Electrical Circuits and Systems
CURRENT CPC	Wind Motors F03D 7/042 (20130101) F03D 7/0272 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/386 (20130101) Dynamo-electric Machines H02K 7/183 (20130101) H02K 11/33 (20160101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/33584 (20130101) H02M 5/458 (20130101) H02M 5/4585 (20130101) Original (OR) Class H02M 7/797 (20130101) H02M 7/4807 (20130101) H02M 7/5387 (20130101) H02M 2001/007 (20130101) H02M 2001/0032 (20130101) Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 9/007 (20130101)
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10205417 — Automated commissioning and inspection for PV systems

US 10205417	Chapman et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	SunPower Corporation (San Jose, California)
ASSIGNEE(S)	Enphase Energy, Inc. (Petaluma, California)
INVENTOR(S)	Patrick L. Chapman (Austin, Texas); Anant Kumar Singh (Richardson, Texas)
ABSTRACT	An electric system includes a local power controller and solar panel system that includes a plurality of solar modules on one or more branch circuits. A method for commissioning the electric system includes an installer using a commissioning device to send and receive information from a remote system and the local power controller performing an automatic self-test of the electric system. The results of the self-test may be packaged with photographs and measurements of the electric system and sent to a remote system where an inspector can inspect the electric system remotely. After receiving approval by the inspector, the local power controller may automatically activate each branch circuit of the electric system and thus enabling the electric system to generate electricity.
FILED	Thursday, March 31, 2016
APPL NO	15/087594
ART UNIT	2115 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/018 (20130101) G06Q 50/06 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/32 (20130101) H02J 3/383 (20130101) H02J 13/002 (20130101) H02J 13/0062 (20130101) H02J 13/0086 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/00 (20130101) Original (OR) Class H02S 50/00 (20130101)
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National Science Foundation (NSF)

10201841 — Sheet transitioning in spiral formed structures

US 10201841	Takata et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Keystone Tower Systems, Inc. (Westminster, Colorado)
ASSIGNEE(S)	Keystone Tower Systems, Inc. (Westminster, Colorado)
INVENTOR(S)	Rosalind K. Takata (Denver, Colorado); Loren Daniel Bridgers (Golden, Colorado); Eric D. Smith (Denver, Colorado)
ABSTRACT	Spiral forming devices, systems, and methods can be used to join edges of a of a stock material, in a curved configuration, along one or more joints to form tubular structures, such as conical and/or cylindrical structures (e.g., frusto-conical structures). A planar form of the stock material can be formed from a plurality planar sheets coupled to one another in an abutting relationship. By controlling relative orientation and shapes of the plurality of planar sheets forming the stock material and/or by controlling a position of a roll bender used to curve the planar form of the stock material into the curved configuration, the curved configuration of the stock material can be controlled through transitions between sheets to facilitate rolling the sheets to a desired diameter with a reduced likelihood of dimples or other errors and to facilitate fit up between adjacent sheets in the curved configuration.
FILED	Thursday, August 31, 2017
APPL NO	15/692461
ART UNIT	3633 — Static Structures, Supports and Furniture
CURRENT CPC	Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/185 (20130101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 31/027 (20130101) Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General E04H 12/08 (20130101)
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10201964 — Treatment for reducing the toxicity of 3D-printed parts

US 10201964	Grover et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	William H. Grover (Riverside, California); Shirin Mesbah Oskui (Los Angeles, California)
ABSTRACT	A method of reducing the toxicity of a 3D-printed part is provided. The method includes exposing the part to ultraviolet light sufficient to reduce the toxicity of the part. The toxicity of the ultraviolet light-treated part can be based on a comparison with the toxicity of a similarly prepared part not exposed to ultraviolet light.
FILED	Wednesday, November 02, 2016
APPL NO	15/342015
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/20 (20170801) B29C 64/35 (20170801) B29C 64/106 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2055/02 (20130101) B29K 2105/0058 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/00 (20141201) B33Y 70/00 (20141201) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/44 (20130101) C08F 236/12 (20130101)
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10202293 — Detection and removal of selenate from aqueous solution

US 10202293	Scherson et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S)	Daniel A. Scherson (Beachwood, Ohio); Jonathan Strobl (Cleveland, Ohio)
ABSTRACT	Systems and methods for detecting and/or removing selenate from an aqueous selenate-containing solution are described. The method includes adding sufficient acid to the aqueous selenate-containing solution to acidify the aqueous selenate-containing solution; contacting the acidic aqueous selenate-containing solution with an underpotantial deposited copper-coated electrode; and removing selenate from the aqueous selenate-containing solution by forming copper-selenide on the underpotential copper-coated electrode.
FILED	Tuesday, August 29, 2017
APPL NO	15/689049
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 19/008 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/58 (20130101) C02F 1/46109 (20130101) Original (OR) Class C02F 2001/46138 (20130101) C02F 2101/106 (20130101) C02F 2201/46135 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 11/0415 (20130101) C25B 11/0447 (20130101)
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10202327 — Highly robust efficient catalyst for selective dehydrogenation of neat glycerol to lactic acid

US 10202327	Williams et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
INVENTOR(S)	Travis J. Williams (Los Angeles, California); Zhiyao Lu (Duarte, California); Ivan Demianets (Los Angeles, California)
ABSTRACT	A catalyst system includes a complex having formula I which advantageously has a sterically protecting N-heterocyclic carbene (NHC) carbene-pyridine ligand to handle harsh reactions conditions than many prior art catalysts: wherein M is a transition metal; o is 0, 1, 2, 3, or 4; R₁is a C_1-6alkyl, a C_6-18aryl, or an optionally substituted C_5-18heteroaryl. In a refinement, R₁is methyl, ethyl, butyl, n-propyl, isopropyl, n-butyl, sec-butyl, or t-butyl; R₂, R₃, R₃′ are independently an optionally substituted C_1-6alkyl, halo (e.g., Cl, F, Br, etc), NO₂, an optionally substituted C_6-18aryl, or an optionally substituted C_5-18heteroaryl; R₄, R₄′ are independently an optionally substituted C_1-6alkyl, halo, NO₂, an optionally substituted C_6-18aryl, or an optionally substituted C_5-18heteroaryl; and X⁻ is a negatively charge counter ion and L₁, L₂are each independently a neutral ligand.
FILED	Thursday, February 02, 2017
APPL NO	15/422728
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2295 (20130101) B01J 2231/763 (20130101) B01J 2531/827 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/326 (20130101) C01B 2203/0227 (20130101) C01B 2203/1064 (20130101) C01B 2203/1223 (20130101) Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 7/14 (20130101) Acyclic or Carbocyclic Compounds C07C 51/16 (20130101) C07C 51/16 (20130101) C07C 51/295 (20130101) Original (OR) Class C07C 51/295 (20130101) C07C 59/08 (20130101) C07C 59/08 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0033 (20130101)
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10202478 — Multigraft copolymer superelastomers by emulsion polymerization

US 10202478	Mays et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF)
APPLICANT(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
INVENTOR(S)	Jimmy W. Mays (Knoxville, Tennessee); Nam-Goo Kang (Knoxville, Tennessee); Qiuyu Zhang (Xi'an, China PRC); Wenwen Wang (Xi'an, China PRC)
ABSTRACT	Multigraft copolymers having various structures, e.g., comb and centipede structures, can be prepared from emulsion copolymerization of monomers and macromonomers. The emulsion copolymerization can be initiated by a thermally activated radical initiator or a redox initiation system. The multigraft copolymers can have high molecular weight and/or a large number of branch points. Elastomer or adhesive compositions of the copolymers can be prepared. Also described are poly(n-alkyl acrylate-graft-styrene) multigraft copolymers.
FILED	Friday, June 19, 2015
APPL NO	15/320530
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 12/08 (20130101) C08F 12/22 (20130101) C08F 12/32 (20130101) C08F 220/18 (20130101) C08F 236/08 (20130101) C08F 290/044 (20130101) Original (OR) Class C08F 290/044 (20130101) C08F 290/044 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 155/005 (20130101)
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10202620 — Synthesis of olefinic alcohols via enzymatic terminal hydroxylation

US 10202620	Coelho et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	PROVIVI, INC. (Santa Monica, California)
ASSIGNEE(S)	PROVIVI, INC. (Santa Monica, California)
INVENTOR(S)	Pedro Coelho (Santa Monica, California); Mike M. Y. Chen (Santa Monica, California); Peter Meinhold (Santa Monica, California); Catherine Mee-Hie Cho (Santa Monica, California); Vu Bui (Santa Monica, California); Thomas Heel (Santa Monica, California)
ABSTRACT	In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes P450 (e.g., cytochromes P450 of the CYP52 and CYP153 family), as well as long chain alkane hydroxylases. In some embodiments, the terminally hydroxylated alkene or alkyne is further converted to a terminal alkenal. In certain embodiments, terminally hydroxylated alkenes and alkynes are useful as insect pheromones which modify insect behavior. In other embodiments, terminally hydroxylated alkenes and alkynes are useful intermediates for producing pheromones via acetylation or oxidation of the alcohol moiety.
FILED	Thursday, September 03, 2015
APPL NO	14/845212
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 1/34 (20130101) C07C 1/34 (20130101) C07C 2/861 (20130101) C07C 2/861 (20130101) C07C 5/09 (20130101) C07C 5/09 (20130101) C07C 6/04 (20130101) C07C 6/04 (20130101) C07C 11/02 (20130101) C07C 11/02 (20130101) C07C 11/02 (20130101) C07C 11/22 (20130101) C07C 29/32 (20130101) C07C 29/32 (20130101) C07C 33/025 (20130101) C07C 45/29 (20130101) C07C 51/235 (20130101) C07C 67/14 (20130101) C07C 67/14 (20130101) C07C 69/145 (20130101) C07C 2523/44 (20130101) C07C 2531/22 (20130101) C07C 2531/24 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/026 (20130101) C12P 7/04 (20130101) Original (OR) Class C12P 7/6418 (20130101)
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10202625 — Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same

US 10202625	Siddiqui et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Michael Shareef Siddiqui (San Mateo, California); Christina D. Smolke (Menlo Park, California)
ABSTRACT	Host cells that are engineered to produce benzylisoquinoline alkaloid (BIAs) precursors, such as norcoclaurine (NC) and norlaudanosoline (NL), are provided. The host cells may have one or more engineered modifications selected from: a feedback inhibition alleviating mutation in a enzyme gene; a transcriptional modulation modification of a biosynthetic enzyme gene; an inactivating mutation in an enzyme; and a heterologous coding sequence. Also provided are methods of producing a BIA of interest or a precursor thereof using the host cells and compositions, e.g., kits, systems etc., that find use in methods of the invention.
FILED	Monday, November 03, 2014
APPL NO	15/031618
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/0071 (20130101) C12N 9/90 (20130101) C12N 9/1085 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/24 (20130101) C12P 13/001 (20130101) C12P 13/225 (20130101) C12P 17/12 (20130101) Original (OR) Class
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10202897 — Systems and methods for transient control of a free-piston engine

US 10202897	Sun et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Zongxuan Sun (Plymouth, Minnesota); Ke Li (Minneapolis, Minnesota)
ABSTRACT	A free-piston (“FP”) engine is a type of internal combustion engine with no crankshaft, so that its piston trajectory is no longer constrained by the mechanical linkage. FP engines have a high potential in terms of energy saving given their simple structure, high modularity and high efficiency, among other attributes. One of the technical barriers that affect FP engine technology is a lack of precise piston trajectory control. For example, the presence of a transient period after a single combustion event can prevent the engine from continuous firing. The present subject matter provides a control scheme that can utilize a reference and control signal shifting technique to modify the tracking error and the control signal to reduce the transient period.
FILED	Tuesday, April 15, 2014
APPL NO	14/784243
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Machines or Engines, in General or of Positive-displacement Type, e.g Steam Engines F01B 11/00 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 71/00 (20130101) Original (OR) Class Controlling Combustion Engines F02D 35/023 (20130101) F02D 41/009 (20130101) F02D 41/1448 (20130101) F02D 45/00 (20130101) F02D 2200/0406 (20130101) F02D 2200/1012 (20130101)
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10203272 — MEMS aerosol impactor

US 10203272	Wilson et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Colorado Seminary, which owns and operates the University of Denver (Denver, Colorado)
ASSIGNEE(S)	Colorado Seminary, University of Denver (Denver, Colorado)
INVENTOR(S)	James C. Wilson (Golden, Colorado); Siavash Pourkamali Anaraki (Dallas, Texas)
ABSTRACT	Embodiments of the invention include aerosol impactors comprising one or more micromechanical resonators. Impactors according to embodiments of the invention can provide size classification and/or concentration of aerosol particulate. Aerosol impactors can use an air flow device, such as a pump, to create a constant flow of air. Nozzles of varying diameters are used to separate particulate of varying sizes and the particles that pass through strike a measuring device. MEMS resonators can be integrated into arrays to provide mass sensitivity in a small, lightweight and cost effective package, which will effectively allow for the measurement of the mass of every micro/nanoscale particle landing on the surface.
FILED	Friday, March 14, 2014
APPL NO	14/777374
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 11/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/22 (20130101) G01N 15/06 (20130101) G01N 15/0255 (20130101) Original (OR) Class G01N 2015/0046 (20130101) G01N 2015/0261 (20130101)
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10204028 — Rule spaces and architecture root detection

US 10204028	Cai et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Drexel University (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Drexel University (Philadelphia, Pennsylvania)
INVENTOR(S)	Yuanfang Cai (Paoli, Pennsylvania); Lu Xiao (Philadelphia, Pennsylvania)
ABSTRACT	Errors in software may be detected via the use of design rule spaces and architecture root detection. Design rule spaces may reveal multiple overlapping modular structures of a software system, and reveal structural relations among error-prone files and structural problems contributing to error-proneness. Root detection may extract a few groups of architecturally connected files, which may be connected through problematic architecture relations that propagate errors among these files, and thus influence system error-proneness. The root detector may locate the core architecturally connected file groups that contribute to the error-proneness of a system. The root detection process may, beginning with a set of error-prone files, search and link other files that are architecturally related. The output of the root detection process may be a set of design rule spaces ordered by the number of error-prone contained therein.
FILED	Friday, September 19, 2014
APPL NO	14/916691
ART UNIT	2192 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 8/36 (20130101) G06F 8/71 (20130101) G06F 8/433 (20130101) G06F 11/3604 (20130101) G06F 11/3608 (20130101) G06F 11/3616 (20130101) Original (OR) Class G06F 11/3692 (20130101) G06F 17/5068 (20130101)
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10204286 — Self-organizing discrete recurrent network digital image codec

US 10204286	Hillar et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	Christopher J. Hillar (San Francisco, California); Kilian Koepsell (San Francisco, California); Ram Mehta (Brooklyn, New York); Jascha Sohl-Dickstein (San Francisco, California)
ASSIGNEE(S)	EMERSYS, INC. (San Francisco, California)
INVENTOR(S)	Christopher J. Hillar (San Francisco, California); Kilian Koepsell (San Francisco, California); Ram Mehta (Brooklyn, New York); Jascha Sohl-Dickstein (San Francisco, California)
ABSTRACT	An invention based on learning a discrete recurrent neural network for a given signal domain is described. In one implementation to the domain of visual images, the method can be used to efficiently compress digital photographs and to devise a new perceptual distortion measure between images that well-matches data collected from a human psychophysics experiment. Other applications of the invention include unsupervised detection of recurrent patterns in high-dimensional data and Shannon-optimal error-correcting coding from few training examples.
FILED	Monday, February 29, 2016
APPL NO	15/056528
ART UNIT	2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6247 (20130101) Original (OR) Class
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10205208 — Method of storing electron hole pairs

US 10205208	Jiang et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Hongrui Jiang (Madison, Wisconsin); Chensha Li (Madison, Wisconsin); Chi-Wei Lo (Madison, Wisconsin)
ABSTRACT	A method and device for harvesting and storing solar energy is provided. The device converts solar energy to electrical energy via the photovoltaic effect. The device includes a pair of electrodes, at least one of which is transparent to allow solar energy to pass through. A medium is disposed between the electrodes which exhibits a combination of photovoltaic and ferroelectric properties. When solar energy passes through the transparent electrode and is received by the medium, electron-hole pairs establish a voltage potential between electrodes in the device via the photovoltaic effect. The voltage potential may be retained and the mobile charge may be stored in the absence of solar energy via the ferroelectric effect.
FILED	Tuesday, June 09, 2015
APPL NO	14/734403
ART UNIT	1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2045 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/022425 (20130101) H01L 31/022466 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/44 (20130101) H01M 10/052 (20130101) H01M 10/425 (20130101) H01M 10/465 (20130101) H01M 10/0565 (20130101) H01M 14/005 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/324 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/542 (20130101)
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10206035 — Simultaneous solution for sparsity and filter responses for a microphone network

US 10206035	Lai et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Mathematical Sciences (DMS)
APPLICANT(S)	University of Maryland (College Park, Maryland)
ASSIGNEE(S)	University of Maryland (College Park, Maryland)
INVENTOR(S)	Yenming Mark Lai (College Park, Maryland); Radu Victor Balan (Rockville, Maryland)
ABSTRACT	Placement of microphones and design of filters in a microphone network are solved simultaneously. Using filterbanks with multiple sub-channels for each microphone, the design of the filter response is solved simultaneously with placement. By using an objective function that penalizes the number of sub-channels in any solution, only some of many possible sub-channels and corresponding microphones and filters are selected while also solving for the filter responses for the selected sub-channels. For a given target location, the location of the microphones and the filter responses to beamform are optimized.
FILED	Wednesday, August 31, 2016
APPL NO	15/252373
ART UNIT	2654 — Audio Signals
CURRENT CPC	Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/406 (20130101) H04R 3/005 (20130101) Original (OR) Class H04R 5/027 (20130101)
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Department of Agriculture (USDA)

10201162 — Pseudomonas species having weed suppressive activity and benign soil survival traits for annual grass weed management

US 10201162	Kennedy
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S)	Ann C. Kennedy (Pullman, Washington)
ABSTRACT	In exemplary embodiments, the disclosure provides weed-suppressive Pseudomonas fluorescens strains effective for controlling one or more invasive grass weeds that are members selected from the group consisting of downy brome (cheatgrass, Bromus tectorum L.), medusahead (Taeniatherum caput medusae (L.) Nevski) and jointed goatgrass (Aegilops cylindrica L.). In exemplary embodiments, the weed-suppressive Pseudomonas fluorescens bacterial strain is a member selected from the group consisting of: Pseudomonas fluorescens strain ACK55, Pseudomonas fluorescens strain NKK78 and Pseudomonas fluorescens strain SMK69. In still other exemplary embodiments the disclosure provides methods for selecting weed-suppressive Pseudomonas fluorescens strains.
FILED	Thursday, January 12, 2017
APPL NO	15/404965
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/00 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 1/39 (20130101)
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10201165 — Formulations and methods for antifungal activity from Prunus maackii periderm

US 10201165	Hammerschmidt et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S)	Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S)	Raymond Hammerschmidt (East Lansing, Michigan); Linzi Kaniszewski (Midland, Michigan); Cory Outwater (Grawn, Michigan)
ABSTRACT	The present invention describes methods and formulations for protecting plants against various pathogens, involving the use of Prunus maackii materials. In some embodiments the biopesticide formulation comprises of at least one flavonoid such as 3,5,7-trihydroxy-6-methoxyflavone, 3,5,7-trihydroxy-6-methoxyflavanone or 5,7-dihydroxy-8-methoxyflavanone. The invention further provides a method of making the biopesticide by extracting a Prunus species with a solvent and formulating the composition using adjuvants, and kits for application of the biopesticide.
FILED	Friday, August 07, 2015
APPL NO	15/502553
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/16 (20130101) A01N 65/00 (20130101) A01N 65/34 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 36/736 (20130101) Technologies for Adaptation to Climate Change Y02A 50/351 (20180101) Y02A 50/354 (20180101)
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10201604 — Live attenuated infectious laryngotracheitis virus (ILTV) vaccines and preparation thereof

US 10201604	Gelb, Jr. et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	UNIVERSITY OF DELAWARE (Newark, Delaware); Jack Gelb, Jr. (Landenberg, Pennsylvania); Brian S. Ladman (Landenberg, Pennsylvania); Miguel Ruano (Newark, Delaware)
ASSIGNEE(S)	UNIVERSITY OF DELAWARE (Newark, Delaware)
INVENTOR(S)	Jack Gelb, Jr. (Landenberg, Pennsylvania); Brian S. Ladman (Landenberg, Pennsylvania); Miguel Ruano (Newark, Delaware)
ABSTRACT	This disclosure describes a modified live infectious laryngotracheitis virus (ILTV) developed from a strain of ILTV grown at a reduced incubation temperature, vaccines that include the modified live ILTV, methods for producing the live modified ILTV, and methods that include administering the modified ILTV to a subject.
FILED	Wednesday, October 29, 2014
APPL NO	15/032338
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/245 (20130101) Original (OR) Class A61K 2039/552 (20130101) A61K 2039/5254 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16034 (20130101) C12N 2710/16064 (20130101) C12N 2710/16334 (20130101) C12N 2710/16362 (20130101) C12N 2710/16364 (20130101)
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10202517 — Polymer compositions and coatings

US 10202517	Catchmark et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania)
ASSIGNEE(S)	The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Jeffrey M. Catchmark (Bellefonte, Pennsylvania); Adam Ross Plucinski (State College, Pennsylvania)
ABSTRACT	This document provides polymer compositions (e.g., biopolymer compositions) and coatings. For example, methods and materials related to polymer compositions (e.g., biopolymer compositions) and coatings as well as methods and materials for making and using such compositions (e.g., biopolymer compositions) and coatings are provided.
FILED	Tuesday, July 15, 2014
APPL NO	14/894914
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/26 (20130101) C08K 3/346 (20130101) C08K 3/346 (20130101) Compositions of Macromolecular Compounds C08L 1/02 (20130101) C08L 1/02 (20130101) C08L 1/02 (20130101) C08L 1/02 (20130101) C08L 1/286 (20130101) C08L 1/286 (20130101) C08L 1/286 (20130101) C08L 5/08 (20130101) C08L 5/08 (20130101) C08L 5/08 (20130101) C08L 89/005 (20130101) C08L 89/005 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 101/286 (20130101) Original (OR) Class C09D 101/286 (20130101) C09D 101/286 (20130101) C09D 101/286 (20130101) C09D 105/00 (20130101) C09D 105/08 (20130101) C09D 105/08 (20130101) C09D 105/08 (20130101) C09D 105/08 (20130101) Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for D21H 11/18 (20130101) D21H 17/22 (20130101) D21H 17/25 (20130101) D21H 17/68 (20130101) D21H 19/40 (20130101) D21H 19/50 (20130101)
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10202557 — Methods of producing calcined coke from bio-oil and calcined coke produced thereby

US 10202557	Elkasabi et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S)	Yaseen M. Elkasabi (Wyncote, Pennsylvania); Akwasi A. Boateng (Royersford, Pennsylvania); Charles A. Mullen (Lansdale, Pennsylvania)
ABSTRACT	Disclosed are methods of producing calcined coke from bio-oil from a biomass feedstock. Also disclosed are calcined cokes produced by such methods.
FILED	Thursday, December 17, 2015
APPL NO	14/972881
ART UNIT	1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 5/361 (20130101) C10L 5/447 (20130101) C10L 9/08 (20130101) Original (OR) Class C10L 2200/0469 (20130101) C10L 2250/06 (20130101) C10L 2290/02 (20130101) C10L 2290/06 (20130101) C10L 2290/10 (20130101) C10L 2290/28 (20130101) C10L 2290/543 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) Y02E 50/30 (20130101)
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Small Business Administration (SBA)

10201538 — Lanthionine synthetase C-like 2-based therapeutics

US 10201538	Bassaganya-Riera et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Small Business Administration (SBA) Small Business Innovation Research (SBIR) Small Business Technology Transfer (STTR)
APPLICANT(S)	Landos Biopharma, Inc. (Blacksburg, Virginia)
ASSIGNEE(S)	LANDOS BIOPHARMA, INC. (Blacksburg, Virginia)
INVENTOR(S)	Josep Bassaganya-Riera (Blacksburg, Virginia); Adria Carbo Barrios (Blacksburg, Virginia); Richard Gandour (Blacksburg, Virginia); Julian D. Cooper (Blacksburg, Virginia); Raquel Hontecillas (Blacksburg, Virginia)
ABSTRACT	Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease.
FILED	Wednesday, June 13, 2018
APPL NO	16/007151
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4439 (20130101) Acyclic or Carbocyclic Compounds C07C 65/40 (20130101) Heterocyclic Compounds C07D 213/69 (20130101) C07D 213/79 (20130101) C07D 307/60 (20130101) C07D 307/68 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101)
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10201841 — Sheet transitioning in spiral formed structures

US 10201841	Takata et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Keystone Tower Systems, Inc. (Westminster, Colorado)
ASSIGNEE(S)	Keystone Tower Systems, Inc. (Westminster, Colorado)
INVENTOR(S)	Rosalind K. Takata (Denver, Colorado); Loren Daniel Bridgers (Golden, Colorado); Eric D. Smith (Denver, Colorado)
ABSTRACT	Spiral forming devices, systems, and methods can be used to join edges of a of a stock material, in a curved configuration, along one or more joints to form tubular structures, such as conical and/or cylindrical structures (e.g., frusto-conical structures). A planar form of the stock material can be formed from a plurality planar sheets coupled to one another in an abutting relationship. By controlling relative orientation and shapes of the plurality of planar sheets forming the stock material and/or by controlling a position of a roll bender used to curve the planar form of the stock material into the curved configuration, the curved configuration of the stock material can be controlled through transitions between sheets to facilitate rolling the sheets to a desired diameter with a reduced likelihood of dimples or other errors and to facilitate fit up between adjacent sheets in the curved configuration.
FILED	Thursday, August 31, 2017
APPL NO	15/692461
ART UNIT	3633 — Static Structures, Supports and Furniture
CURRENT CPC	Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/185 (20130101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 31/027 (20130101) Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General E04H 12/08 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10203188 — Rotational control actuation system

US 10203188	Sowle et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Armament Research, Development and Engineering Center (ARDEC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Zak Sowle (Bellbrook, Ohio); Srikanth Vasudevan (Shelton, Connecticut); Matthew C. Birch (Madison, Alabama)
ASSIGNEE(S)	Orbital Research Inc (Cleveland, Ohio)
INVENTOR(S)	Zak Sowle (Bellbrook, Ohio); Srikanth Vasudevan (Shelton, Connecticut); Matthew C. Birch (Madison, Alabama)
ABSTRACT	A projectile incorporates one or more spoiler-tabbed spinning disks to effect flow around the projectile and thus impart steering forces and/or moments. The spoiler tabs may be deployed only during steering phases of travel thus minimizing the drag penalty associated with steering systems. The disks are driven by motors and informed and controlled by sensors and electronic control systems. The spoiler tabs protrude through the surface of the projectile only for certain angles of spin of the spinning disk. For spin-stabilized projectiles, the disks spin at substantially the same rate as the projectile, but the disks may function in fin-stabilized projectiles as well. Any number of such spinning flow effector disks may be incorporated in a projectile, with the manner of functional coordination differing slightly for even and odd numbers of disks.
FILED	Wednesday, February 28, 2018
APPL NO	15/907541
ART UNIT	3647 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 13/00 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 10/00 (20130101) F42B 10/26 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10204168 — Systems and methods for automatically identifying and linking names in digital resources

US 10204168	Parker et al.
FUNDED BY	Department of Energy (DOE) Small Business Administration (SBA) Small Business Technology Transfer (STTR)
APPLICANT(S)	NAMESFORLIFE, LLC (East Lansing, Michigan)
ASSIGNEE(S)	NAMESFORLIFE, LLC (East Lansing, Michigan)
INVENTOR(S)	Charles T. Parker (East Lansing, Michigan); Catherine M. Lyons (Edinburgh, United Kingdom); Gerald P. Roston (Saline, Michigan); George M. Garrity (Okemos, Michigan)
ABSTRACT	The present invention provides systems and methods for automatically identifying name-like-strings in digital resources, matching these name-like-string against a set of names held in an expertly curated database, and for those name-like-strings found in said database, enhancing the content by associating additional matter with the name, wherein said matter includes information about the names that is held within said database and pointers to other digital resources which include the same name and it synonyms.
FILED	Tuesday, June 06, 2017
APPL NO	15/615171
ART UNIT	2162 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 17/30864 (20130101) G06F 17/30887 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Department of Homeland Security (DHS)

10203286 — Continuous interleaved process for conducting an assay in a multi-well plate

US 10203286	Clinton et al.
FUNDED BY	Department of Homeland Security (DHS) Science and Technology Directorate (DHS-ST)
APPLICANT(S)	Charles M. Clinton (Clarksburg, Maryland); Eli N. Glezer (Chevy Chase, Maryland); Sharon West (Rockville, Maryland); George Sigal (Rockville, Maryland); Carl Stevens (Silver Spring, Maryland); Michael L. Vock (Loveland, Ohio)
ASSIGNEE(S)	Meso Scale Diagnostics, LLC (Gaithersburg, Maryland)
INVENTOR(S)	Charles M. Clinton (Clarksburg, Maryland); Eli N. Glezer (Chevy Chase, Maryland); Sharon West (Rockville, Maryland); George Sigal (Rockville, Maryland); Carl Stevens (Silver Spring, Maryland); Michael L. Vock (Loveland, Ohio)
ABSTRACT	We describe a method for conducting an assay in a multi-well assay plate using an apparatus comprising a light detection subsystem, a liquid handling subsystem, and a plate handling subsystem. This is particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, it may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
FILED	Friday, April 10, 2009
APPL NO	12/422081
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/69 (20130101) G01N 21/76 (20130101) Original (OR) Class G01N 35/028 (20130101) G01N 35/0092 (20130101) G01N 35/1079 (20130101) G01N 2035/0425 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/114165 (20150115)
VIEW PATENT	@ USPTO: Full Text PDF

10203325 — Metallic nanoparticle synthesis with carbohydrate capping agent

US 10203325	Alocilja et al.
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan)
ASSIGNEE(S)	BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan)
INVENTOR(S)	Evangelyn C. Alocilja (East Lansing, Michigan); Hanna Miller (Midland, Michigan)
ABSTRACT	The disclosure relates to metal nanoparticle compositions and their methods of formation and use, in particular gold nanoparticles (AuNP) and gold-coated magnetic nanoparticles. Compositions according to the disclosure include aqueous suspensions of metal nanoparticles that are stabilized with one or more carbohydrate capping agents and/or that are functionalized with one or more binding pair members for capture/detection of a target analyte. The nanoparticle suspensions are stable for extended periods and can be functionalized as desired at a later point in time, typically prior to use in an assay for the detection of a target biological analyte. The stable nanoparticle suspension can be formed by the aqueous reduction of oxidized metal precursors at non-acidic pH values in the presence of a carbohydrate-based capping agent such as dextrin or other oligosaccharides.
FILED	Wednesday, November 07, 2012
APPL NO	14/356406
ART UNIT	1677 — Organic Chemistry
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/16 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5434 (20130101) G01N 33/54326 (20130101) Original (OR) Class G01N 33/54346 (20130101) G01N 33/56911 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Veterans Affairs (DVA)

10201588 — Materials and methods of treating dyslipidemia

US 10201588	Romero-Lucas et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	UNIVERSITY OF MIAMI (Miami, Florida); AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia)
ASSIGNEE(S)	UNIVERSITY OF MIAMI (Miami, Florida); AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia)
INVENTOR(S)	Maritza Romero-Lucas (Martinez, Georgia); Andrew Schally (Miami Beach, Florida); Rudolf Lucas (Martinez, Georgia); Neal Weintraub (Augusta, Georgia)
ABSTRACT	Described herein are materials and methods for treating dyslipidemia in a mammalian subject in need thereof comprising administering a growth hormone-releasing hormone (GHRH) antagonist or variant thereof to the subject.
FILED	Thursday, January 19, 2017
APPL NO	15/409789
ART UNIT	1675 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10201703 — Integrated surface stimulation device for wound therapy and infection control

US 10201703	Bogie et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	The United States of America, as represented by the Department of Veterans Affairs (Washington, District of Columbia); Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	The United States of America, as represented by the Department of Veterans Affairs (Washington, District of Columbia); Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Kath M. Bogie (Shaker Heights, Ohio); Steven L. Garverick (Cleveland Heights, Ohio); Christian A. Zorman (Euclid, Ohio); Daniel S. Howe (San Diego, California)
ABSTRACT	The present invention provides a thin and flexible device and method of use thereof for wound treatment and infection control. The integrated surface stimulation device may comprise a complete wireless stimulation system in a disposable and/or reusable flexible device for widespread use in multiple therapeutic applications. The invention would be situated on the skin surface of a patient and would be activated so as to reduce the overall occurrence of infections and/or increase wound healing rates. As provided, the device will comprise an integrated power supply and pre-programmable stimulator/control system on a flexible polymeric substrate layer with areas of stimulating electrodes, applied using techniques such as those found in additive manufacturing processes. The device is especially valuable in treating biofilm-based infections.
FILED	Tuesday, March 31, 2015
APPL NO	14/675270
ART UNIT	3762 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0468 (20130101) A61N 1/0472 (20130101) A61N 1/36014 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/135 (20170801) B29C 64/386 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2079/08 (20130101) B29K 2105/16 (20130101) B29K 2505/14 (20130101) B29K 2995/0005 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/753 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) B33Y 80/00 (20141201)
VIEW PATENT	@ USPTO: Full Text PDF

Central Intelligence Agency (CIA)

10204775 — High pressure mass spectrometry systems and methods

US 10204775	Brown et al.
FUNDED BY	Central Intelligence Agency (CIA)
APPLICANT(S)	908 Devices Inc. (Boston, Massachusetts)
ASSIGNEE(S)	908 Devices Inc. (Boston, Massachusetts)
INVENTOR(S)	Christopher D. Brown (Los Gatos, California); Glenn A. Harris (Boston, Massachusetts); Evgeny Krylov (Franklin, Massachusetts); Scott Miller (Malden, Massachusetts)
ABSTRACT	Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.
FILED	Friday, April 15, 2016
APPL NO	15/130426
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/24 (20130101) H01J 49/26 (20130101) H01J 49/0031 (20130101) H01J 49/0095 (20130101) H01J 49/107 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Department of Commerce (DOC)

10201916 — Gas dispersion manufacture of nanoparticulates, and nanoparticulate-containing products and processing thereof

US 10201916	Kodas et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	SICPA HOLDING SA (Prilly, Switzerland)
ASSIGNEE(S)	SICPA HOLDING SA (Prilly, Switzerland)
INVENTOR(S)	Toivo T. Kodas (Carlisle, Massachusetts); Mark J. Hampden-Smith (Albuquerque, New Mexico); Klaus Kunze (Carlsbad, California); David E. Dericotte (Albuquerque, New Mexico); Karel Vanheusden (Los Altos, California); Aaron Stump (Albuquerque, New Mexico)
ABSTRACT	In one aspect, the present invention relates to a method of making multi-phase particles that include nanoparticulates and matrix, which maintains the nanoparticulates in a dispersed state. A flowing gas dispersion is generated that includes droplets of a precursor medium dispersed in a gas phase. The precursor medium contains liquid vehicle and at least a first precursor to a first material and a second precursor to a second material. The multi-phase particles are formed from the gas dispersion by removing at least a portion of the liquid vehicle from the droplets of precursor medium. The nanoparticulates in the multi-phase particles include the first material and the matrix in the multi-phase particles includes the second material.
FILED	Thursday, October 17, 2013
APPL NO	14/056134
ART UNIT	1619 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0043 (20130101) B01J 13/0047 (20130101) B01J 13/0095 (20130101) Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 9/12 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Department of Transportation (USDOT)

10202135 — Operations monitoring in an area

US 10202135	Mian et al.
FUNDED BY	Department of Transportation (USDOT)
APPLICANT(S)	International Electronic Machines Corporation (Troy, New York)
ASSIGNEE(S)	International Electronic Machines Corp. (Troy, New York)
INVENTOR(S)	Zahid F. Mian (Loudonville, New York); Ronald W. Gamache (East Greenbush, New York); Ryk E. Spoor (Troy, New York)
ABSTRACT	An assembly for monitoring an area is provided. The assembly can include two or more cameras sensitive to radiation of distinct wavelength ranges. The fields of view of the cameras can be substantially co-registered at the area to be monitored. The assembly can include a computer system which can process the image data to monitor the area. The computer system can be configured to identify relevant objects present in the area, update tracking information for the relevant objects, and evaluate whether an alert condition is present using the tracking information.
FILED	Friday, May 16, 2014
APPL NO	14/279385
ART UNIT	2487 — Recording and Compression
CURRENT CPC	Guiding Railway Traffic; Ensuring the Safety of Railway Traffic B61L 23/041 (20130101) B61L 29/30 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00771 (20130101) G06K 9/6293 (20130101) Image Data Processing or Generation, in General G06T 7/194 (20170101) G06T 7/254 (20170101) G06T 2207/10016 (20130101) G06T 2207/10048 (20130101) G06T 2207/20221 (20130101) G06T 2207/30236 (20130101) Traffic Control Systems G08G 1/04 (20130101) G08G 1/005 (20130101) G08G 1/017 (20130101) G08G 1/166 (20130101) G08G 1/0175 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of the Interior (DOI)

10201570 — Halogen treatment of heart attack and ischemic injury

US 10201570	Roth et al.
FUNDED BY	Department of the Interior (DOI)
APPLICANT(S)	Fred Hutchinson Cancer Research Center (Seattle, Washington)
ASSIGNEE(S)	Fred Hutchinson Cancer Research Center (Seattle, Washington)
INVENTOR(S)	Mark B. Roth (Seattle, Washington); Michael L. Morrison (Seattle, Washington); Akiko Iwata (Seattle, Washington)
ABSTRACT	The present invention relates to the use of halogen compounds, including iodide, and chalcogenide compounds, including iodide, sulfide and selenide, to treat and prevent diseases and injuries. The present invention further relates to compositions comprising a halogen compound and/or a chalcogenide compound, including pharmaceutical compositions, as well as methods of manufacturing such compounds and administering such compositions to subjects in need thereof.
FILED	Tuesday, February 10, 2015
APPL NO	15/117602
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 33/00 (20130101) A61K 33/04 (20130101) A61K 33/04 (20130101) A61K 33/16 (20130101) A61K 33/16 (20130101) A61K 33/18 (20130101) Original (OR) Class A61K 33/18 (20130101) A61K 38/063 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Technologies for Adaptation to Climate Change Y02A 50/481 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

National Aeronautics and Space Administration (NASA)

10201278 — Life detecting radars

US 10201278	Lux et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	James Paul Lux (Thousand Oaks, California); Vaughn P. Cable (Woodland Hills, California); Salman-ul Mohammed Haque (Los Angeles, California); Michael Ray McKee (Lancaster, California); Hirad Ghaemi (Pasadena, California); Richard Kalantar Ohanian (Glendale, California)
ABSTRACT	Systems and methods for detecting biometrics using a life detecting radar are disclosed. Life detecting radars can include transmit antennas configured to transmit continuous microwave (“CW”) radio signals that reflect back upon making contact with various objects. The signal can be systematically varied in frequency to provide a signal that is essentially continuous with short gaps between transmissions at different frequencies. The reflected return signals are received by one or more receive antennas and processed to detect one or more targets. The received signal can include a static (i.e. constant phase) signal corresponding to reflections from objects that do not move. The received signal can also include a phase varying signal that corresponds to reflections from a living target having measurable biometrics including (but not limited to) breathing patterns and heartbeats. Clutter can be removed and the remaining portions of the received signal are analyzed for target detection.
FILED	Friday, April 18, 2014
APPL NO	14/256748
ART UNIT	3737 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0022 (20130101) Original (OR) Class A61B 5/024 (20130101) A61B 5/117 (20130101) A61B 5/0507 (20130101) A61B 5/0816 (20130101) A61B 5/1126 (20130101) A61B 5/7257 (20130101) Devices, Apparatus or Methods for Life-saving A62B 33/00 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/003 (20130101) G01S 13/56 (20130101) G01S 13/88 (20130101) G01S 13/347 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

Non-Profit Organization (NPO)

10202507 — Antithrombotic compounds, methods and uses thereof

US 10202507	Kizhakkedathu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) Non-Profit Organization (NPO) American Heart Association (AHA)
APPLICANT(S)	The University of British Columbia (Vancouver, Canada); The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The University of British Columbia (Vancouver, Canada); The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Jayachandran Kizhakkedathu (New Westminster, Canada); James H. Morrissey (Champaign, Illinois); Richard J. Travers (Champaign, Illinois); Rajesh Shenoi (Richmond, Canada); Manu Thomas Kalathottukaren (Vancouver, Canada)
ABSTRACT	Provided herein are polymers and methods for their use in binding a phosphate containing biological macromolecules. Specifically, the methods and uses provided herein may be used to inhibit thrombin binding to polyphosphate or as an antithrombotic agent for the treatment of stroke, acute coronary syndrome, pulmonary embolism, atrial fibrillation, venous and arterial thromboembolism, disseminated intravascular coagulation (DIC), deep-vein thrombosis (DVT), peripheral artery disease, trauma-induced coagulopathy, extracorporeal circulation, cancer-associated thrombosis, sepsis, septic shock, Systemic Inflammatory Response Syndrome (SIRS), or inflammation.
FILED	Friday, May 29, 2015
APPL NO	15/313774
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/785 (20130101) Compositions of Macromolecular Compounds C08L 79/02 (20130101) Original (OR) Class C08L 101/005 (20130101) C08L 2203/02 (20130101) C08L 2207/53 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

U.S. State Government

10201279 — Sweat sensing device communication security and compliance

US 10201279	Heikenfeld et al.
FUNDED BY	U.S. State Government State of Ohio
APPLICANT(S)	Eccrine Systems, Inc. (Cincinnati, Ohio)
ASSIGNEE(S)	University of Cincinnati, A University of the State of Ohio (Cincinnati, Ohio)
INVENTOR(S)	Jason Heikenfeld (Cincinnati, Ohio); Daniel P. Rose (Cincinnati, Ohio); Ian Papautsky (Willowbrook, Illinois); Wenjing Kang (Malden, Massachusetts); Xiao Wang (Malden, Massachusetts); Michael Ratterman (South Lebanon, Ohio)
ABSTRACT	The invention addresses confounding difficulties involving continuous sweat analyte measurement. Specifically, the present invention provides: at least one component capable of monitoring whether a sweat sensing device is in sufficient contact with a wearer's skin to allow proper device operation; at least one component capable of monitoring whether the device is operating on a wearer's skin; at least one means of determining whether the device wearer is a target individual within a probability range; at least one component capable of generating and communicating alert messages to the device user(s) related to: wearer safety, wearer physiological condition, compliance with a requirement to wear a device, device operation; compliance with a behavior requirement, or other purposes that may be derived from sweat sensor data; and the ability to utilize aggregated sweat sensor data that may be correlated with information external to the device to enhance the predictive capabilities of the device.
FILED	Monday, November 28, 2016
APPL NO	15/362299
ART UNIT	3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0002 (20130101) A61B 5/0022 (20130101) Original (OR) Class A61B 5/024 (20130101) A61B 5/112 (20130101) A61B 5/117 (20130101) A61B 5/0205 (20130101) A61B 5/0531 (20130101) A61B 5/0533 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/1477 (20130101) A61B 5/4266 (20130101) A61B 5/4833 (20130101) A61B 5/4845 (20130101) A61B 5/6802 (20130101) A61B 5/6833 (20130101) A61B 5/6843 (20130101) A61B 5/7275 (20130101) A61B 5/7475 (20130101) A61B 5/14517 (20130101) A61B 5/14521 (20130101) A61B 5/14546 (20130101) A61B 5/14551 (20130101) A61B 2560/0252 (20130101) A61B 2562/08 (20130101) A61B 2562/125 (20130101) A61B 2562/164 (20130101) A61B 2562/0214 (20130101) A61B 2562/0219 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/30 (20130101) B05D 3/007 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 37/12 (20130101) B32B 2535/00 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00892 (20130101) G06K 2009/00939 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/18 (20130101) Selecting H04Q 9/00 (20130101) H04Q 2209/40 (20130101) Technologies for Adaptation to Climate Change Y02A 90/26 (20180101) Technical Subjects Covered by Former US Classification Y10T 29/49155 (20150115)
VIEW PATENT	@ USPTO: Full Text PDF

United States Postal Service (USPS)

10202248 — Transformable tray and tray system for receiving, transporting and unloading items

US 10202248	Stratton et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	Christopher M. Stratton (Springfield, Virginia); Gregory J. Smith (Arlington, Virginia); Thomas C. Potter (Oak Hill, Virginia); Wayne R. Perry-Eaton (Leesburg, Virginia)
ABSTRACT	Features for loading, transporting and unloading of items are disclosed. Systems, devices and methods for such operations using a tray are described. In some embodiments, a tray having a moveable bottom allows for switching between a configuration for loading and unloading items in and out of the tray and a configuration for transportation of items inside the tray. The trays may also be stacked, for transportation of multiple trays at once, and nested, for saving space when storing the trays. In some embodiments, the trays may be used in conjunction with loading and unloading systems.
FILED	Tuesday, September 29, 2015
APPL NO	14/869843
ART UNIT	3652 — Material and Article Handling
CURRENT CPC	Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/008 (20130101) Machines, Apparatus or Devices For, or Methods Of, Packaging Articles or Materials; Unpacking B65B 5/10 (20130101) Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 65/32 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20190212.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

info@wayfinder.digital