FedInvent™ Patents

Patent Details for Tuesday, March 12, 2019

This page was updated on Monday, March 27, 2023 at 05:45 AM GMT

Department of Health and Human Services (HHS)

10226173 — System and method for real-time montaging from live moving retina

US 10226173	Rossi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Ethan A. Rossi (Pittsburgh, Pennsylvania); Qiang Yang (Rochester, New York)
ASSIGNEE(S)	University of Rochester (Rochester, New York)
INVENTOR(S)	Ethan A. Rossi (Pittsburgh, Pennsylvania); Qiang Yang (Rochester, New York)
ABSTRACT	A scanning LASER ophthalmoscope (SLO) system for real-time montaging includes an adaptive optics scanning light ophthalmoscope (AOSLO) and a wide field scanning light ophthalmoscope (WFSLO). At least one stabilization mirror is controlled by a computer to optically stabilize the AOSLO based at least in part on feedback from the WFSLO. The SLO system also includes a steering means. The SLO system continues to acquire and combine a plurality of AOSLO image frames forming a combined AOSLO image at each of a plurality of narrow field of view (FOV) sites until a predetermined number of images or a predetermined image quality metric (IQM) at each of the combined AOSLO images is achieved. A plurality of the combined AOSLO images is combined to form a SLO montaged image of a wide FOV. A method to montage a plurality of scanning LASER ophthalmoscope (SLO) narrow field of view (FOV) images is also described.
FILED	Monday, July 06, 2015
APPL NO	15/324467
ART UNIT	2872 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/13 (20130101) A61B 3/14 (20130101) A61B 3/0025 (20130101) A61B 3/0058 (20130101) A61B 3/1025 (20130101) Original (OR) Class
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10226206 — Systems and methods for measuring neonatal cerebral oxygenation

US 10226206	Esenaliev et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	The Board Of Regents of the University Of Texas System (Austin, Texas)
INVENTOR(S)	Rinat O. Esenaliev (League City, Texas); Donald S. Prough (Galveston, Texas); Yuriy Petrov (Galveston, Texas); Irene Y. Petrov (Galveston, Texas); C. Joan Richardson (Galveston, Texas)
ABSTRACT	Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.
FILED	Friday, March 11, 2016
APPL NO	15/067707
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0095 (20130101) A61B 5/6803 (20130101) A61B 5/14546 (20130101) A61B 5/14552 (20130101) Original (OR) Class A61B 5/14553 (20130101) A61B 2503/045 (20130101)
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10226304 — Shape tracking of a dexterous continuum manipulator

US 10226304	Iordachita et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Iulian Iordachita (Lutherville-Timonium, Maryland); Hao Liu (Baltimore, Maryland); Mehran Armand (Fulton, Maryland); Russell H. Taylor (Severna Park, Maryland); Amirhossein Farvardin (Baltimore, Maryland)
ABSTRACT	A shape sensor system includes a deflection sensor comprising an optical fiber having at least one fiber Bragg grating (FBG) written therein and a substrate, the fiber being attached to the substrate with a selected bias distance from a neutral plane of the deflection sensor. The system further includes an optical source coupled to the fiber to provide input light to be at least partially reflected by the FBG, and an optical detection and processing system arranged to receive at least a portion of the output light and to determine a wavelength shift resulting from a change of an amount of deflection of the deflection sensor. The optical detection and processing system determines a relative amount of deflection of the deflection sensor at the FBG based on the wavelength shift. The selected bias distance is selected based on an expected range of deflection angles to be detected.
FILED	Tuesday, December 15, 2015
APPL NO	14/970177
ART UNIT	3659 — Material and Article Handling
CURRENT CPC	Diagnosis; Surgery; Identification A61B 34/30 (20160201) Original (OR) Class A61B 34/35 (20160201) A61B 34/71 (20160201) A61B 2034/301 (20160201) A61B 2034/306 (20160201) A61B 2034/2061 (20160201) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/24 (20130101) G01B 11/165 (20130101)
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10226381 — Multi-photon absorption for femtosecond micromachining and refractive index modification of tissues

US 10226381	Knox et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	University of Rochester (Rochester, New York)
ASSIGNEE(S)	University of Rochester (Rochester, New York)
INVENTOR(S)	Wayne H. Knox (Pittsford, New York); Krystel R. Huxlin (Rush, New York); Li Ding (Pleasanton, California)
ABSTRACT	By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.
FILED	Friday, January 13, 2017
APPL NO	15/405717
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/008 (20130101) A61F 9/00804 (20130101) A61F 9/00827 (20130101) Original (OR) Class A61F 9/00829 (20130101) A61F 2009/0087 (20130101) A61F 2009/0088 (20130101) A61F 2009/00842 (20130101) A61F 2009/00846 (20130101) A61F 2009/00848 (20130101) A61F 2009/00872 (20130101)
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10226424 — Therapeutic calcium phosphate nanoparticle incorporating siRNA useful in treating disease

US 10226424	Parette et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Mylisa Parette (Bellefonte, Pennsylvania); Danielle Asquino (Philipsburg, Pennsylvania); Kari Eyer (Sinking Spring, Pennsylvania); James Adair (State College, Pennsylvania); Jeff Davidson (Boalsburg, Pennsylvania); Mark Kester (Harrisburg, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S)	Mylisa Parette (Bellefonte, Pennsylvania); Danielle Asquino (Philipsburg, Pennsylvania); Kari Eyer (Sinking Spring, Pennsylvania); James Adair (State College, Pennsylvania); Jeff Davidson (Boalsburg, Pennsylvania); Mark Kester (Harrisburg, Pennsylvania)
ABSTRACT	Stable, non-toxic, calcium phosphate nanoparticles are formed that incorporate one or more oligonucleotides. RNAi nucleotides may be incorporated and, in particular, siRNA nucleotides. Since the siRNA nanoparticles dissociate leaving only naturally occurring residual materials, calcium and phosphate, along with the siRNA, they are particularly useful as carrier vehicles. The ability to incorporate more than one siRNA provides a means to block or knock down the translation of multiple targeted proteins at the same time.
FILED	Saturday, August 10, 2013
APPL NO	13/964062
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) Original (OR) Class A61K 9/0019 (20130101) A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 47/60 (20170801) A61K 47/6923 (20170801) Technical Subjects Covered by Former US Classification Y10T 428/2982 (20150115)
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10226427 — Surface binding of nanoparticle based drug delivery to tissue

US 10226427	Bajpayee et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Ambika Goel Bajpayee (Cambridge, Massachusetts); Alan Grodzinsky (Lexington, Massachusetts); Cliff Richard Wong (Cambridge, Massachusetts); Moungi G. Bawendi (Cambridge, Massachusetts); Rohit N. Karnik (Cambridge, Massachusetts)
ABSTRACT	Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury such as trauma.
FILED	Wednesday, March 16, 2016
APPL NO	15/071709
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/167 (20130101) Original (OR) Class A61K 31/573 (20130101) A61K 38/18 (20130101) A61K 47/60 (20170801) A61K 47/64 (20170801) A61K 47/551 (20170801) A61K 47/645 (20170801)
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10226434 — Design, synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity

US 10226434	Radtke et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland)
ASSIGNEE(S)	University of Maryland, Baltimore County (Baltimore, Maryland); Katholieke Universiteit Leuven/Lieden University Medical Center, RC Leiden (Belgium, Netherlands)
INVENTOR(S)	Katherine L. Radtke (Baltimore, Maryland); Hannah Peters (Baltimore, Maryland); Johan Neyts (Leuven, Belgium); Dirk Jochmans (Leuven, Belgium); Eric J. Snijder (RC Leiden, Netherlands)
ABSTRACT	The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
FILED	Monday, July 02, 2018
APPL NO	16/025284
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/08 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/4178 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 403/04 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/582 (20151101)
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10226438 — Sobetirome in the treatment of myelination diseases

US 10226438	Scanlan et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Thomas S. Scanlan (San Francisco, California); Meredith Hartley (Portland, Oregon); Andrew Placzek (Portland, Oregon); Marco Righi (Rosignano, Italy); Dennis Bourdette (Portland, Oregon); Gail Marracci (Portland, Oregon); Priya Chaudhary (Portland, Oregon)
ASSIGNEE(S)	Oregon Health and Science University (Portland, Oregon); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Thomas S. Scanlan (San Francisco, California); Meredith Hartley (Portland, Oregon); Andrew Placzek (Portland, Oregon); Marco Righi (Rosignano, Italy); Dennis Bourdette (Portland, Oregon); Gail Marracci (Portland, Oregon); Priya Chaudhary (Portland, Oregon)
ABSTRACT	Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.
FILED	Wednesday, February 05, 2014
APPL NO	14/888577
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/0095 (20130101) A61K 31/192 (20130101) Original (OR) Class
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10226439 — Small molecule inhibitors of STAT3 with anti-tumor activity

US 10226439	Turkson et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
ASSIGNEE(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
INVENTOR(S)	James Turkson (Honolulu, Hawaii); Said M. Sebti (Tampa, Florida); Wayne Guida (St. Petersburg Beach, Florida); Man Lun Yip (Monrovia, California); Nicholas Lawrence (Tampa, Florida); Harshani Rithma Lawrence (Tampa, Florida); Benjamin Greedy (Somerset, United Kingdom)
ABSTRACT	The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis. The invention further includes an in-vitro screening test for the presence of malignant cells in a mammalian tissue; a method of identifying inhibitors of constitutive Stat3 activation, Stat3-DNA binding, Stat5-DNA binding, and/or Stat3 dimerization; and a method of identifying anti-cancer agents.
FILED	Friday, March 24, 2017
APPL NO	15/468460
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/18 (20130101) A61K 31/18 (20130101) A61K 31/196 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2300/00 (20130101) Acyclic or Carbocyclic Compounds C07C 235/84 (20130101) C07C 309/73 (20130101) C07C 311/19 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5011 (20130101) G01N 33/5088 (20130101) G01N 33/57407 (20130101) G01N 33/57484 (20130101)
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10226443 — Methods for treating psoriatic arthritis

US 10226443	Scher et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Jose U. Scher (Jersey City, New Jersey); Carles Ubeda (Valencia, Spain); Dan R. Littman (New York, New York); Eric G. Pamer (Guilford, Connecticut); Steven B. Abramson (Rye, New York); Sergei B. Koralov (Millburn, New Jersey)
ASSIGNEE(S)	New York University (New York, New York); Memorial Sloan-Kettering Cancer Center (New York, New York); Fundacion Para El Fomento De La Investigacion Sanitaria Y Biomedica De La Comunitat Valenciana (Fisabio) (Valencia, Spain)
INVENTOR(S)	Jose U. Scher (Jersey City, New Jersey); Carles Ubeda (Valencia, Spain); Dan R. Littman (New York, New York); Eric G. Pamer (Guilford, Connecticut); Steven B. Abramson (Rye, New York); Sergei B. Koralov (Millburn, New Jersey)
ABSTRACT	Methods, agents and compositions thereof for treating psoriatic arthritis (PsA) are encompassed herein.
FILED	Friday, October 16, 2015
APPL NO	14/885084
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/20 (20130101) Original (OR) Class A61K 35/74 (20130101) A61K 45/06 (20130101)
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10226452 — Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments

US 10226452	Piomelli et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Genoa, Italy); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California); Fondazione Istituto Italiano di Tecnologia (Genoa, Italy)
INVENTOR(S)	Daniele Piomelli (Irvine, California); Chiara Pagliuca (Arezzo, Italy); Daniela Pizzirani (Genoa, Italy); Anders Bach (Valby, Denmark); Natalia Realini (Valmorea, Italy); Marco De Vivo (Genoa, Italy)
ABSTRACT	The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
FILED	Tuesday, November 08, 2016
APPL NO	15/346443
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) Original (OR) Class A61K 31/4439 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 263/58 (20130101) C07D 413/12 (20130101)
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10226476 — Method of attenuating reactions to skin irritants

US 10226476	Wilson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S)	S. Brian Wilson (Lexington, Massachusetts); Glenn Dranoff (Lexington, Massachusetts); Silke Gillessen (St. Gallen, Switzerland)
ABSTRACT	The present invention is directed to a method of inhibiting CD1d activation by administering a composition containing a moiety that blocks CD1d activation. Compositions of the invention are useful for the attenuation of CD1d-restricted immune responses, including treatment of skin disorders due to hyperactive immune responses (e.g., contact hypersensitivity), for systemic administration to attenuate ongoing immune responses, and to provide hypoallergenic cosmetic products including pharmaceutical, cosmetic, and skin care compositions. Preferably, these compositions are in a form intended for topical administration.
FILED	Friday, July 17, 2015
APPL NO	14/802893
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 8/68 (20130101) A61K 8/553 (20130101) A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 31/00 (20130101) A61K 31/66 (20130101) A61K 31/133 (20130101) A61K 31/164 (20130101) A61K 31/661 (20130101) A61K 31/685 (20130101) Original (OR) Class A61K 31/739 (20130101) A61K 31/765 (20130101) A61K 31/7028 (20130101) A61K 31/7032 (20130101) A61K 47/60 (20170801) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 7/00 (20130101) A61Q 17/00 (20130101) A61Q 19/00 (20130101) Peptides C07K 16/2803 (20130101) C07K 16/2896 (20130101) C07K 2317/76 (20130101)
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10226481 — Pharmaceutical compositions composed of low molecular weight sulfated hyaluronan

US 10226481	Prestwich et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S)	University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Glenn D. Prestwich (Eastsound, Washington); Siam Oottamasathien (Salt Lake City, Utah); Wanjian Jia (Salt Lake City, Utah); Lindsi M. Roundy (Salt Lake City, Utah); Won Yong Lee (Salt Lake City, Utah)
ABSTRACT	Described herein are pharmaceutical compositions composed of low molecular weight sulfated hyaluronan.
FILED	Friday, December 16, 2016
APPL NO	15/381187
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 2/38 (20130101) A23L 2/52 (20130101) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 31/728 (20130101) A61K 31/737 (20130101) Original (OR) Class A61K 31/737 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0072 (20130101)
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10226483 — Topical compositions and methods of using the same

US 10226483	Doxey et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Novan, Inc. (Morrisville, North Carolina)
ASSIGNEE(S)	Novan, Inc. (Morrisville, North Carolina)
INVENTOR(S)	Ryan Doxey (Raleigh, North Carolina); Jian Bao (Cary, North Carolina)
ABSTRACT	The present invention generally relates to topical compositions and methods of using the same. The topical compositions may comprise a hydrophilic composition and a hydrophobic composition in admixture. The hydrophobic composition may include a nitric oxide-releasing compound such as, for example, a diazeniumdiolate functionalized co-condensed silica particle. In some embodiments, the topical composition may be self-emulsifying. Further described herein are kits comprising a hydrophilic composition and a hydrophobic composition.
FILED	Wednesday, May 02, 2018
APPL NO	15/969628
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 8/25 (20130101) A61K 8/042 (20130101) A61K 8/345 (20130101) A61K 8/898 (20130101) A61K 9/06 (20130101) A61K 9/10 (20130101) A61K 9/0014 (20130101) A61K 9/107 (20130101) A61K 33/00 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 47/10 (20130101) A61K 47/12 (20130101) A61K 47/14 (20130101) A61K 47/32 (20130101) A61K 47/38 (20130101) A61K 47/44 (20130101) A61K 47/52 (20170801) A61K 47/59 (20170801) A61K 2800/22 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/005 (20130101) A61Q 19/00 (20130101)
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10226485 — Multipotent adult stem cells and methods for isolation

US 10226485	Furcht et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Leo T. Furcht (Minneapolis, Minnesota); Catherine M. Verfaillie (St. Paul, Minnesota); Morayma Reyes (Minneapolis, Minnesota)
ASSIGNEE(S)	ABT Holding Company (Cleveland, Ohio); Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Leo T. Furcht (Minneapolis, Minnesota); Catherine M. Verfaillie (St. Paul, Minnesota); Morayma Reyes (Minneapolis, Minnesota)
ABSTRACT	The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
FILED	Monday, March 21, 2005
APPL NO	11/084256
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 48/00 (20130101) A61K 2035/124 (20130101) A61K 2039/5156 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0607 (20130101) C12N 2501/11 (20130101) C12N 2501/105 (20130101) C12N 2501/135 (20130101) C12N 2501/235 (20130101) C12N 2503/00 (20130101) C12N 2510/00 (20130101) Enzymes C12Y 207/07049 (20130101)
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10226506 — Treatment and diagnosis of inflammatory disorders and HIV

US 10226506	Kachlany et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Rutgers, The State University of New Jersey (New Brunswick, New Jersey); Actinobac Biomed, Inc. (Kendall Park, New Jersey)
ASSIGNEE(S)	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey); ACTINOBAC BIOMED, INC. (Kendall Park, New Jersey)
INVENTOR(S)	Scott C. Kachlany (Bridgewater, New Jersey); Benjamin Belinka (Kendall Park, New Jersey)
ABSTRACT	This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
FILED	Wednesday, December 06, 2017
APPL NO	15/833544
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/164 (20130101) Original (OR) Class A61K 38/164 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 47/6849 (20170801) A61K 51/1093 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) Peptides C07K 16/2896 (20130101) C07K 2317/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5052 (20130101) G01N 33/56911 (20130101) G01N 33/56988 (20130101) G01N 2800/26 (20130101) G01N 2800/52 (20130101) G01N 2800/709 (20130101) G01N 2800/7095 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 530/825 (20130101)
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10226509 — Lymphangiogenesis inhibitors for cancer and for graft survival

US 10226509	Panjwani et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	TUFTS UNIVERSITY (Boston, Massachusetts)
ASSIGNEE(S)	Tufts University (Boston, Massachusetts)
INVENTOR(S)	Noorjahan Panjwani (Medford, Massachusetts); Wei-Sheng Chen (Kaohsiung, Taiwan)
ABSTRACT	Compositions and methods are provided for treating and/or preventing lymphangiogenesis in a subject by using an inhibitor of a galectin-8 protein in an amount effective to inhibit or to modulate an activity of the galectin-8 protein or a portion thereof sufficient to inhibit the lymphangiogenesis associated with cancer, corneal injury, dry eye disease, inflammation, lymphedema, organ rejection or graft rejection.
FILED	Friday, December 23, 2016
APPL NO	15/389509
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/702 (20130101) A61K 38/47 (20130101) A61K 38/1732 (20130101) Original (OR) Class Enzymes C12Y 302/02029 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/912 (20130101) G01N 2333/4724 (20130101) G01N 2800/52 (20130101)
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10226514 — Methods and compositions for reducing blood glucose levels

US 10226514	Ozcan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Umut Ozcan (Jamaica Plains, Massachusetts); Jaemin Lee (Brookline, Massachusetts)
ABSTRACT	A method of reducing blood glucose in a subject has been developed. In preferred embodiments, the method involves administering to the subject a specific activator of endogenous mitogen-activated protein kinase kinase 6 (MKK3), mitogen-activated protein kinase kinase 6 (MKK4), mitogen-activated protein kinase kinase 6 (MKK6), p38 mitogen-activated protein kinase (p38MAPK), mitogen-activated kinase-activated protein kinase 2 (MK2), or a combination thereof, in an effective amount to reduce blood glucose in a subject. In other embodiments, the method involves administering to the subject a specific activator to increase X-box binding protein 1 (XBP1) phosphorylation on Thr48 and Ser61 in an effective amount to reduce blood glucose in the subject. Methods of identifying agents for reducing blood glucose in a subject are also provided.
FILED	Tuesday, August 08, 2017
APPL NO	15/671705
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/66 (20130101) A61K 38/45 (20130101) Original (OR) Class Enzymes C12Y 207/12002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/573 (20130101) G01N 2333/4703 (20130101) G01N 2440/14 (20130101) G01N 2800/042 (20130101)
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10226520 — Compositions and methods for enterohemorrhagic Escherichia coli (EHEC) vaccination

US 10226520	Torres
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Alfredo G. Torres (Friendswood, Texas)
ASSIGNEE(S)	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXA SYSTEM (Austin, Texas)
INVENTOR(S)	Alfredo G. Torres (Friendswood, Texas)
ABSTRACT	Certain embodiments are directed to compositions comprising EHEC-specific antigens. In certain aspects EHEC O157:H7-specific antigen(s) are used as components of immunogenic compositions and vaccines.
FILED	Friday, February 17, 2017
APPL NO	15/436044
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/0258 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/543 (20130101) A61K 2039/545 (20130101) A61K 2039/552 (20130101) A61K 2039/575 (20130101) A61K 2039/55594 (20130101)
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10226521 — Genetically modified Yersinia as vaccines against Yersinia species

US 10226521	Curtiss et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Roy Curtiss (Gainesville, Florida); Wei Sun (Gainesville, Florida)
ABSTRACT	Recombinant attenuated Y. pseudotuberculosis mutants have been created that show efficacy as oral vaccines against plague caused by Y. pestis and Yersinosis caused by both Y. enterocolitica and Y. pseudotuberculosis. Thus, live attenuated Y. pseudotuberculosis-based vaccines can be used to prevent Yersinosis in farm animals such as swine, cattle and sheep. The palatable baits containing live attenuated Y. pseudotuberculosis-based vaccines may be acceptable methods to control plague epidemics in wild animals. The methods disclosed can also be used to generate recombinant attenuated Y. entercolitica and Y. pestis vaccine strains.
FILED	Thursday, September 10, 2015
APPL NO	14/850811
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/0291 (20130101) Original (OR) Class A61K 2039/58 (20130101) A61K 2039/522 (20130101) A61K 2039/523 (20130101) A61K 2039/542 (20130101) A61K 2039/572 (20130101)
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10226522 — Compositions and methods for the treatment or prevention of tuberculosis

US 10226522	King et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	GlobeImmune, Inc. (Louisville, Colorado); Colorado State University Research Foundation (Fort Collins, Colorado)
ASSIGNEE(S)	GLOBEIMMUNE, INC. (Louisville, Colorado); COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado)
INVENTOR(S)	Thomas H. King (Denver, Colorado); Zhimin Guo (Superior, Colorado); Ian M. Orme (Fort Collins, Colorado)
ABSTRACT	Disclosed are yeast-based immunotherapeutic compositions and fusion proteins for the treatment and/or prevention of TB infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions and fusion proteins for the prophylactic and/or therapeutic treatment of TB and/or symptoms thereof.
FILED	Friday, August 29, 2014
APPL NO	14/914790
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/04 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/521 (20130101) A61K 2039/523 (20130101) Peptides C07K 14/35 (20130101)
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10226527 — Hemagglutinin polypeptides, and reagents and methods relating thereto

US 10226527	Tharakaraman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Kannan Tharakaraman (Arlington, Massachusetts); Karthik Viswanathan (Waltham, Massachusetts); Rahul Raman (Waltham, Massachusetts); Ram Sasisekharan (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Kannan Tharakaraman (Arlington, Massachusetts); Karthik Viswanathan (Waltham, Massachusetts); Rahul Raman (Waltham, Massachusetts); Ram Sasisekharan (Cambridge, Massachusetts)
ABSTRACT	The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
FILED	Tuesday, October 04, 2011
APPL NO	13/253060
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16134 (20130101)
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10226528 — Vaccines with biomolecular adjuvants

US 10226528	Weiner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	David B. Weiner (Merion, Pennsylvania); Karuppiah Muthumani (Cherry Hill, New Jersey)
ASSIGNEE(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
INVENTOR(S)	David B. Weiner (Merion, Pennsylvania); Karuppiah Muthumani (Cherry Hill, New Jersey)
ABSTRACT	Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
FILED	Friday, March 14, 2014
APPL NO	14/774428
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 41/0047 (20130101) A61K 2039/53 (20130101) A61K 2039/55516 (20130101) A61K 2039/55522 (20130101) Peptides C07K 14/52 (20130101) C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16034 (20130101) C12N 2740/16134 (20130101) C12N 2740/16171 (20130101) C12N 2740/16234 (20130101) C12N 2740/16271 (20130101)
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10226534 — Semi-solid delivery systems

US 10226534	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Wenshou Wang (Quincy, Massachusetts); Chun Wang (Minneapolis, Minnesota)
ABSTRACT	The invention provides semi-solid systems for delivering biologically active materials that include a polymer comprising 1) one or more polycaprolactone (PCL) units and 2) at least one or more polyethylene glycol (PEG) units; wherein at least one of said polycaprolactone units is conjugated to a PEG forming an acetal group.
FILED	Friday, September 12, 2014
APPL NO	15/021573
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 9/0024 (20130101) A61K 9/5153 (20130101) A61K 38/385 (20130101) A61K 47/34 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/664 (20130101) C08G 65/3312 (20130101) C08G 81/00 (20130101) C08G 2650/44 (20130101) Compositions of Macromolecular Compounds C08L 71/02 (20130101)
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10226536 — Polysaccharide therapeutic conjugates

US 10226536	Gao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Songqi Gao (Beachwood, Ohio); Krzysztof Palczewski (Bay Village, Ohio); Zheng-Rong Lu (Beachwood, Ohio)
ABSTRACT	A composition includes a polysaccharide at least one retinoid linked to at least one monosaccharide subunit of the polysaccharide with a covalent linkage. The linkage being degradable by hydrolysis during digestion of the composition to provide controlled, delayed, and/or sustained delivery of the at least one retinoid upon enteral administration of the composition to a subject.
FILED	Wednesday, November 28, 2012
APPL NO	14/361163
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/07 (20130101) A61K 31/07 (20130101) A61K 31/11 (20130101) A61K 31/11 (20130101) A61K 31/722 (20130101) A61K 31/722 (20130101) A61K 47/61 (20170801) Original (OR) Class A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10226564 — Vascular access port systems and methods

US 10226564	Young et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Advent Access Pte. Ltd. (Singapore, Singapore)
ASSIGNEE(S)	Advent Access Pte. Ltd. (Singapore, Singapore)
INVENTOR(S)	Nathaniel P. Young (Salt Lake City, Utah); G. Doug Smith (Sandy, Utah); Mark A. Crawford (Sandy, Utah)
ABSTRACT	In certain systems disclosed herein, one or more of a first vascular access port and a second vascular access port can be selected by a customer. Each of the first and second vascular access ports can be implanted subcutaneously within a patient, and each can include a base configured to be attached to a vessel, a body that extends away from the base, and a guidance passageway that extends through the body and the base and includes a funnel region. A maximum height defined by the base and body of the second vascular access port can be greater than a maximum height defined by the base and body of the first vascular access port.
FILED	Monday, May 18, 2015
APPL NO	14/715553
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/0057 (20130101) A61B 17/3423 (20130101) A61B 2017/00641 (20130101) A61B 2017/00654 (20130101) A61B 2017/3425 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/3653 (20130101) Original (OR) Class A61M 1/3659 (20140204) A61M 1/3661 (20140204) A61M 39/0208 (20130101) A61M 2039/0223 (20130101) A61M 2039/0226 (20130101) A61M 2039/0238 (20130101) A61M 2205/0238 (20130101)
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10226591 — Methods and devices for carbon dioxide-based sleep disorder therapy

US 10226591	Tarler
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Cleveland Medical Devices Inc. (Cleveland, Ohio)
ASSIGNEE(S)	Cleveland Medical Devices Inc. (Cleveland, Ohio)
INVENTOR(S)	Matthew D. Tarler (Westlake, Ohio)
ABSTRACT	The present invention pertains to a system, method, and device for treating sleep disorders. The present invention is particularly useful in the delivery of carbon dioxide (CO2) to a subject and in the treatment of sleep apnea. Furthermore, integration of components with various sensors and apparatuses associated therewith and attached thereto preferably complete a rebreathing circuit in the present invention. In various embodiments of the present invention where the above components are integrated as a rebreathing circuit, a subject is both the source and recipient of a controlled concentration of carbon dioxide. In such embodiments, treatment of sleep disorders becomes much more efficient and effective.
FILED	Tuesday, September 25, 2012
APPL NO	13/626011
ART UNIT	3785 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/06 (20130101) A61M 16/10 (20130101) A61M 16/12 (20130101) A61M 16/0045 (20130101) Original (OR) Class A61M 16/122 (20140204) A61M 16/0883 (20140204) A61M 2016/103 (20130101) A61M 2202/0225 (20130101)
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10226768 — Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting

US 10226768	Chiou et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Aeronautics and Space Administration (NASA) National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Pei-Yu E. Chiou (Los Angeles, California); Ting-Hsiang S. Wu (Culver City, California); Michael A. Teitell (Tarzana, California)
ABSTRACT	In certain embodiments this invention provides a pulsed-laser triggered microfluidic switching mechanism that can achieve a switching time of 70 μs. This switching speed is two orders of magnitude shorter than that of the fastest switching mechanism utilized in previous μFACS.
FILED	Friday, April 08, 2016
APPL NO	15/094919
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0636 (20130101) B01L 2200/0652 (20130101) B01L 2300/123 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2400/0442 (20130101) B01L 2400/0454 (20130101) B01L 2400/0622 (20130101) B01L 2400/0655 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0001 (20130101) F16K 99/004 (20130101) F16K 99/0026 (20130101) F16K 99/0028 (20130101) F16K 99/0061 (20130101) F16K 2099/0084 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1459 (20130101) G01N 2015/149 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0391 (20150401) Y10T 137/2224 (20150401)
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10227290 — Glycosphingolipids for use in modulating immune responses

US 10227290	Fischbach et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD)
APPLICANT(S)	The Regents of the University of California (Oakland, California); President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California); President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Michael A. Fischbach (San Francisco, California); Jeffrey A. Bluestone (San Francisco, California); Cristina Penaranda (Boston, Massachusetts); Laura Brown (Bloomington, Indiana); Jon Clardy (Jamaica Plain, Massachusetts)
ABSTRACT	Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.
FILED	Thursday, February 07, 2013
APPL NO	14/376747
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/26 (20130101) A61K 2035/122 (20130101) Acyclic or Carbocyclic Compounds C07C 235/08 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/1411 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/04 (20130101) C07H 15/06 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/02 (20130101) C12P 19/44 (20130101)
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10227291 — Docosahexaenoyl ethanolamides

US 10227291	Serhan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH) National Institute of Dental and Craniofacial Research (NIDCR) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S)	THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
INVENTOR(S)	Charles N. Serhan (Needham, Massachusetts); Rong Yang (Los Angeles, California)
ABSTRACT	The invention describes novel mono or dihydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
FILED	Thursday, July 07, 2016
APPL NO	15/203925
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) Acyclic or Carbocyclic Compounds C07C 235/28 (20130101) Original (OR) Class Heterocyclic Compounds C07D 303/14 (20130101) C07D 303/46 (20130101) Peptides C07K 5/0215 (20130101)
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10227295 — Selective histone deactylase 6 inhibitors

US 10227295	Sotomayor et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida); Board of Trustees of The University of Illinois (Urbana, Illinois)
INVENTOR(S)	Eduardo M. Sotomayor (Tampa, Florida); Joel A. Bergman (Chicago, Illinois); Alan P. Kozikowski (Chicago, Illinois); Alejandro V. Villagra (Tampa, Florida); Karrune V. Woan (Gainesville, Florida)
ABSTRACT	Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula I. Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.
FILED	Tuesday, September 05, 2017
APPL NO	15/695435
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/42 (20130101) A61K 31/44 (20130101) A61K 31/185 (20130101) A61K 31/416 (20130101) A61K 31/437 (20130101) A61K 31/505 (20130101) A61K 31/4045 (20130101) A61K 45/06 (20130101) Acyclic or Carbocyclic Compounds C07C 275/28 (20130101) C07C 275/34 (20130101) Original (OR) Class C07C 275/40 (20130101) Heterocyclic Compounds C07D 209/14 (20130101) C07D 213/75 (20130101) C07D 231/56 (20130101) C07D 233/26 (20130101) C07D 233/74 (20130101) C07D 233/78 (20130101) C07D 239/42 (20130101) C07D 261/14 (20130101) C07D 295/13 (20130101)
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10227304 — Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof

US 10227304	Yang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Wenjin Yang (Foster City, California); Che-Hong Chen (Fremont, California); Daria Mochly-Rosen (Menlo Park, California)
ABSTRACT	The present disclosure provides compounds of formula (I) that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity, and methods of preparing these compounds.
FILED	Monday, April 24, 2017
APPL NO	15/495670
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 233/66 (20130101) C07C 233/73 (20130101) C07C 233/78 (20130101) C07C 233/87 (20130101) C07C 235/48 (20130101) C07C 235/60 (20130101) C07C 237/32 (20130101) C07C 311/16 (20130101) C07C 311/17 (20130101) C07C 311/29 (20130101) C07C 311/40 (20130101) C07C 317/32 (20130101) C07C 2601/02 (20170501) C07C 2601/04 (20170501) C07C 2601/08 (20170501) Heterocyclic Compounds C07D 213/81 (20130101) C07D 213/82 (20130101) Original (OR) Class C07D 213/89 (20130101) C07D 317/58 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101)
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10227369 — Short-chain fatty acid hexosamine analogs and their use in tissue engineering applications

US 10227369	Elisseeff et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Jennifer H. Elisseeff (Baltimore, Maryland); Kevin Yarema (Woodstock, Maryland); Jeannine Coburn (Baltimore, Maryland); Udayanath Aich (Brighton, Massachusetts)
ABSTRACT	A new class of molecules, C₁—OH tributanoylated hexosamines, including, for example, GalNAc, GlcNAc and ManNAc, are demonstrated to increase cartilage-like tissue accumulation by IL-1β-stimulated chondrocytes. Furthermore, all three molecules reduced NFKB1 and IκBα driven gene expression, consistent with NFκB inhibitory properties of these analogs. GalNAc-a exposure produced the greatest ECM accumulation by IL-1β-stimulated chondrocytes. However, GalNAc-a exposure produced an opposite effect on MSC exposure, where a decrease in ECM accumulation was observed. These findings are in support of the function of NFκB signaling during limb development and growth plate chondrogenesis. The present invention shows the capability of this new class of hexosamine analogs as disease-modifying agents for treating cartilage damage.
FILED	Tuesday, March 11, 2014
APPL NO	14/774805
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7008 (20130101) A61K 31/7008 (20130101) A61K 31/7024 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 13/04 (20130101) Original (OR) Class
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10227370 — Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity

US 10227370	Sheng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Gloria J. Sheng (Silver Spring, Maryland); Linda C. Hsieh-Wilson (South Pasadena, California)
ABSTRACT	The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive methods.
FILED	Friday, August 01, 2014
APPL NO	14/450192
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/18 (20130101) Original (OR) Class
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10227384 — Modified proteins and methods of use thereof

US 10227384	Schepartz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	YALE UNIVERSITY (New Haven, Connecticut)
INVENTOR(S)	Alanna S. Schepartz (Wilton, Connecticut); Jacob S. Applebaum (Haven, Connecticut); Jonathan R. LaRochelle (New Haven, Connecticut)
ABSTRACT	This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embodiments of the invention relate to modified protein fusion molecules that reach the cytosol.
FILED	Monday, April 14, 2014
APPL NO	14/783943
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/645 (20170801) A61K 47/6455 (20170801) Peptides C07K 7/08 (20130101) C07K 14/00 (20130101) Original (OR) Class C07K 14/47 (20130101) C07K 14/465 (20130101) C07K 14/575 (20130101) C07K 2319/10 (20130101) C07K 2319/81 (20130101)
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10227387 — Targeted delivery of proteins across the blood-brain barrier

US 10227387	Pan
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Dao Pan (Cincinnati, Ohio)
ASSIGNEE(S)	Children's Hospital Medical Center (Cincinnati, Ohio)
INVENTOR(S)	Dao Pan (Cincinnati, Ohio)
ABSTRACT	Embodiments of the invention are directed to compositions comprising a peptide sequence, or a nucleic acid encoding the same, wherein the peptide sequence includes a receptor-binding region of apolipoprotein E (apoE), or a sequence variant or fragment thereof, for directing delivery of a given protein or therapeutic across the blood brain barrier. Embodiments of the invention are also directed to methods of using the compositions for treating or preventing a neurological disorder, disease, or symptom in a subject in need thereof.
FILED	Friday, May 18, 2012
APPL NO	14/117978
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/47 (20130101) A61K 48/0075 (20130101) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 2319/10 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/15043 (20130101) Enzymes C12Y 302/01076 (20130101)
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10227390 — Stabilized polypeptide insulin receptor modulators

US 10227390	Verdine et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S)	Gregory L. Verdine (Boston, Massachusetts); Gerard Hilinski (Somerville, Massachusetts); Rebecca Yue Liang (Cambridge, Massachusetts); Yvonne Alice Nagel (Somerville, Massachusetts); Minyun Zhou (Malden, Massachusetts)
ABSTRACT	Provided herein are stabilized α-CT polypeptides comprising an alpha-helical segment, and wherein the polypeptide is of Formula (I-1) or Formula (I-2): R^f—[X_AA]_s—X_A1—X_A2—X_A3—X_A4—X_A5—X_A6—X_A7—X_A8—X_A9—X_A10—X_A11—X_A12—X_A13—X_A14—[X_AA]_t—R^e(I-1) R^f—[X_AA]_s—X_C1—X_C2—X_C3—X_C4—X_C5—X_C6—X_C7—X_C8—X_C9—X_C10—X_C11—X_C12—X_C13—X_C14—X_C15—X_C16—X_C17—X_C18—X_C19—X_C20—[X_AA]_t—R^e(I-2) wherein the α-CT polypeptide binds to the insulin receptor, and wherein the α-CT polypeptide includes at least one staple (i.e. two cross-linked amino acids) and/or at least one stitch (i.e. three cross-linked amino acids). Further provided are insulin analogs including the stapled or stitched α-CT polypeptides, pharmaceutical compositions thereof, methods of use, e.g., methods of treating a diabetic condition or complications thereof.
FILED	Friday, June 13, 2014
APPL NO	14/898222
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/62 (20130101) Original (OR) Class C07K 14/72 (20130101)
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10227391 — System and method for controlling G-protein coupled receptor pathways

US 10227391	Herlitze et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Stefan Herlitze (Cleveland, Ohio); Lynn Landmesser (Cleveland, Ohio)
ABSTRACT	A light-sensitive G-protein coupled receptor includes a light sensitive extracellular cone opsin or melanopsin domain and a hetorologous intracellular domain capable of modulating an intracellular signaling pathway.
FILED	Monday, March 14, 2016
APPL NO	15/069364
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/705 (20130101) Original (OR) Class C07K 14/70571 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) C12N 2510/00 (20130101)
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10227394 — Polypeptide compositions with type VII collagen fibronectin type III-like repeats and treatment methods for wound closure and healing

US 10227394	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S)	University of Southern California (Los Angeles, California)
INVENTOR(S)	Mei Chen (Altadena, California); David T. Woodley (Altadena, California)
ABSTRACT	Disclosed are compositions and methods for accelerating wound closure and preventing inhibiting or reducing scarring or fibrosis. The methods of the present invention include administering to a person in need thereof an effective amount of a pharmaceutical composition comprising collagen 7 and/or one or more functional fragments or variants thereof. The functional fragments generally comprise at least one of the nine Fibronectin Type III-like Region of the NC1 region of collagen 7.
FILED	Wednesday, April 08, 2015
APPL NO	15/302453
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 38/00 (20130101) A61K 47/42 (20130101) Peptides C07K 14/78 (20130101) Original (OR) Class
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10227395 — Monoclonal antibodies that neutralize anthrax protective antigen (PA) toxin

US 10227395	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Washington, District of Columbia)
INVENTOR(S)	Zhaochun Chen (Potomac, Maryland); Stephen H. Leppla (Bethesda, Maryland); Mahtab Moayeri (Bethesda, Maryland); Suzanne U. Emerson (Gaithersburg, Maryland); Robert H. Purcell (Gaithersburg, Maryland)
ABSTRACT	The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (PA) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax PA toxin-binding ability, fully human or humanized antibodies retaining anthrax PA toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
FILED	Friday, February 14, 2014
APPL NO	14/181099
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/1278 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/52 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101)
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10227398 — Anti-complement factor C1q antibodies and uses thereof

US 10227398	Rosenthal et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	Annexon, Inc. (South San Francisco, California)
ASSIGNEE(S)	Annexon, Inc. (South San Francisco, California)
INVENTOR(S)	Arnon Rosenthal (Woodside, California); Michael Leviten (Emerald Hills, California)
ABSTRACT	The present invention provides anti-C1q antibodies and methods of using the same.
FILED	Wednesday, April 19, 2017
APPL NO	15/491574
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0004 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/734 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56966 (20130101) G01N 2333/4716 (20130101)
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10227399 — Human Notch1 decoys

US 10227399	Kitajewski et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
INVENTOR(S)	Jan Kitajewski (Ridgewood, New Jersey); Carrie Shawber (Township of Washington, New Jersey); Thaned Kangsamaksin (Lampang, Thailand)
ABSTRACT	Provided herein are Notch1 fusion proteins. These fusion proteins comprise consecutive amino acids the sequence of which, commencing at the N-terminus of the fusion protein, is identical to the sequence of the amino acids in an extracellular domain of a human Notch1 receptor protein and an Fc portion of an antibody. The amino acid sequence of the extracellular domain (ECD) of the human Notch1 receptor protein commences with the amino acid present at the N-terminus of EGF-like repeat 10 and extends at least through the C-terminal amino acid of EGF-like repeat 23. The N-terminal portion of the ECD of the human Notch1 receptor protein may extend up to the C-terminal amino acid of EGF-like repeat 24 or may extend up to the C-terminal amino acid of EGF-like repeat 36. Compositions of these fusion proteins are also provided. Also provided are methods of treating age-related macular degeneration (AMD), diabetic retinopathy and cancer using the fusion proteins described herein.
FILED	Wednesday, July 05, 2017
APPL NO	15/641712
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) A61K 38/179 (20130101) A61K 38/1774 (20130101) A61K 38/1793 (20130101) Peptides C07K 14/71 (20130101) C07K 14/705 (20130101) C07K 14/715 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 16/283 (20130101) C07K 19/00 (20130101) C07K 2319/30 (20130101) C07K 2319/32 (20130101)
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10227419 — Antibodies targeting B-cell receptor complex membrane bound IgM and uses thereof

US 10227419	Welt et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Welt Bio-Molecular Pharmaceutlical, LLC (Armonk, New York)
ASSIGNEE(S)	Welt Bio-Molecular Pharmaceutical, LLC. (Armonk, New York)
INVENTOR(S)	Sydney Welt (Armonk, New York); David Kostyal (Akron, Ohio); Rachel S Welt (Armonk, New York); Virginia Raymond (Armonk, New York); Jonathan A Welt (Armonk, New York)
ABSTRACT	The present invention relates to antibodies targeting the membrane bound IgM (mIgM) of the B-cell receptor complex found in B-cell lymphomas and leukemias and uses thereof. Another aspect of the present invention is the use of anti-B-Cell mIgM antibodies in the treatment of Be-cell malignancies, including B-cell lymphomas and leukemias.
FILED	Tuesday, February 13, 2018
APPL NO	15/895386
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/2803 (20130101) C07K 16/4283 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/34 (20130101) C07K 2317/56 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/77 (20130101) C07K 2317/565 (20130101) C07K 2317/732 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/163 (20130101)
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10227556 — Cell culture devices for biomimetic and pathomimetic cell cultures

US 10227556	Sloane et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Wayne State University (Detroit, Michigan)
ASSIGNEE(S)	Wayne State University (Detroit, Michigan)
INVENTOR(S)	Bonnie F. Sloane (Royal Oak, Michigan); Yong Xu (Troy, Michigan); Kyungmin Ji (Troy, Michigan); Hongen Tu (Warren, Michigan); Kamiar Moin (West Bloomfield, Michigan); Kingsley Osuala (Detroit, Michigan)
ABSTRACT	Cell culture devices and methods of their use are provided according to aspects of the present invention which include a base having a pair of spaced apart wells and at least one fluid port defined from an exterior of the base to each of the wells, each fluid port being spaced above the base sheet by a distance sufficient to introduce a material above a matrix deposited on the base sheet in the wells; and a cover having a pair of spaced apart well covering portions that are each disposed above a respective one of the one spaced apart wells of the base body when the cover is covering the upper surface of the base body and having a gas passage defined between the spaced apart well covering portions and at least one gas port defined from an exterior of the cover to each of the well covering portions.
FILED	Tuesday, September 06, 2016
APPL NO	15/257264
ART UNIT	1799 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 23/22 (20130101) C12M 23/26 (20130101) C12M 23/34 (20130101) C12M 23/38 (20130101) C12M 23/58 (20130101) C12M 25/14 (20130101) C12M 29/26 (20130101) C12M 41/12 (20130101) C12M 41/26 (20130101) C12M 41/34 (20130101) C12M 41/46 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0656 (20130101) C12N 5/0693 (20130101) C12N 2500/02 (20130101) C12N 2500/32 (20130101) C12N 2500/84 (20130101) C12N 2501/999 (20130101) C12N 2502/30 (20130101) C12N 2502/1323 (20130101) C12N 2509/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101)
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10227562 — Process for sorting motile particles from lesser-motile particles and apparatus suitable therefor

US 10227562	Takayama et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Shuichi Takayama (Ann Arbor, Michigan); Gary D. Smith (Ann Arbor, Michigan); Timothy G. Schuster (Ann Arbor, Michigan); Brenda S. Cho (Ann Arbor, Michigan)
ABSTRACT	Motile particles are sorted from non-motile particles in a microfluidic sorting device wherein a stream of sort fluid containing motile and non-motile particles is caused to flow adjacent a media stream in non-turbulent fashion through a sort channel, during which flow motile particles cross the interface between the adjacent flow streams, entering the media stream, and forming a motile particle-depleted sort stream. The sorting devices are easily and inexpensively fabricated and have numerous uses, in particular sorting of motile from non-motile sperm.
FILED	Wednesday, December 14, 2016
APPL NO	15/378980
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 3/502776 (20130101) B01L 2200/0636 (20130101) B01L 2200/0647 (20130101) B01L 2200/0652 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2400/0406 (20130101) B01L 2400/0457 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0612 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101)
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10227566 — Three dimensional matrix for cancer stem cells

US 10227566	Jabbari
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	University of South Carolina (Columbia, South Carolina)
ASSIGNEE(S)	University of South Carolina (Columbia, South Carolina)
INVENTOR(S)	Esmaiel Jabbari (Columbia, South Carolina)
ABSTRACT	Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.
FILED	Wednesday, October 29, 2014
APPL NO	14/527028
ART UNIT	1675 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0695 (20130101) Original (OR) Class C12N 2533/30 (20130101) C12N 2537/10 (20130101)
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10227569 — Respiratory syncytial virus expression vectors

US 10227569	Moore et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR)
APPLICANT(S)	Martin L. Moore (Decatur, Georgia); Anne Hotard (Atlanta, Georgia)
ASSIGNEE(S)	EMORY UNIVERSITY (Atlanta, Georgia); CHILDREN'S HEALTHCARE OF ATLANTA, INC. (Atlanta, Georgia)
INVENTOR(S)	Martin L. Moore (Decatur, Georgia); Anne Hotard (Atlanta, Georgia)
ABSTRACT	In certain embodiments, the disclosure relates to vectors containing bacterial nucleic acid sequences and a paramyxovirus gene. Typically, the expression vector comprises a bacterial artificial chromosome (BAC), and a nucleic acid sequence comprising a respiratory syncytial virus (RSV) gene in operable combination with a regulatory element and optionally a reporter gene.
FILED	Wednesday, April 11, 2012
APPL NO	13/444338
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2760/18543 (20130101) C12N 2760/18552 (20130101) C12N 2800/50 (20130101) C12N 2800/204 (20130101)
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10227581 — Engineered transcription activator-like effector (TALE) domains and uses thereof

US 10227581	Liu et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	David R. Liu (Lexington, Massachusetts); John Paul Guilinger (Ridgway, Colorado); Vikram Pattanayak (Cambridge, Massachusetts)
ABSTRACT	Engineered transcriptional activator-like effectors (TALEs) are versatile tools for genome manipulation with applications in research and clinical contexts. One current drawback of TALEs is their tendency to bind and cleave off-target sequence, which hampers their clinical application and renders applications requiring high-fidelity binding unfeasible. This disclosure provides engineered TALE domains and TALEs comprising such engineered domains, e.g., TALE nucleases (TALENs), TALE transcriptional activators, TALE transcriptional repressors, and TALE epigenetic modification enzymes, with improved specificity and methods for generating and using such TALEs.
FILED	Friday, August 22, 2014
APPL NO	14/913458
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 2319/00 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/01 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Enzymes C12Y 301/00 (20130101)
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10227590 — Antisense oligonucleotides for inducing exon skipping and methods of use thereof

US 10227590	Wilton et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The University of Western Australia (Crawley, Australia)
ASSIGNEE(S)	The University of Western Australia (Crawley, Australia)
INVENTOR(S)	Stephen Donald Wilton (Applecross, Australia); Sue Fletcher (Bayswater, Australia); Graham McClorey (Bayswater, Australia)
ABSTRACT	An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.
FILED	Friday, August 24, 2018
APPL NO	16/112371
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/33 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/3233 (20130101) C12N 2310/3341 (20130101) C12N 2310/3519 (20130101) C12N 2320/30 (20130101) C12N 2320/33 (20130101)
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10227597 — Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway

US 10227597	Ajikumar et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); National University of Singapore (Singapore, Singapore)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); National University of Singapore (Singapore, Singapore)
INVENTOR(S)	Parayil K. Ajikumar (Cambridge, Massachusetts); Gregory Stephanopoulos (Winchester, Massachusetts); Heng Phon Too (Singapore, Singapore)
ABSTRACT	The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
FILED	Thursday, September 28, 2017
APPL NO	15/718748
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 15/00 (20130101) C12P 17/02 (20130101)
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10227629 — Diagnosis and treatment of invasive aspergillosis

US 10227629	Koo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S)	Sophia Koo (Brookline, Massachusetts); Horatio R. Thomas (Cambridge, Massachusetts); Lindsey R. Baden (Brookline, Massachusetts); Francisco M. Marty (Chestnut Hill, Massachusetts)
ABSTRACT	Methods for diagnosing, treating, and monitoring the treatment of invasive aspergillosis (IA) are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having IA.
FILED	Thursday, June 04, 2015
APPL NO	15/316062
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/082 (20130101) A61B 5/4836 (20130101) A61B 5/14546 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/497 (20130101) G01N 2033/4975 (20130101) G01N 2333/38 (20130101) G01N 2800/18 (20130101) G01N 2800/26 (20130101) G01N 2800/52 (20130101)
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10227639 — Compositions and methods for analyte detection

US 10227639	Levner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Daniel Levner (Boston, Massachusetts); Je-Hyuk Lee (Allston, Massachusetts); George M. Church (Brookline, Massachusetts); Michael Super (Lexington, Massachusetts)
ABSTRACT	The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
FILED	Friday, December 21, 2012
APPL NO	14/366486
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6804 (20130101) C12Q 1/6816 (20130101) C12Q 1/6816 (20130101) C12Q 1/6837 (20130101) Original (OR) Class C12Q 2535/122 (20130101) C12Q 2535/122 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2563/107 (20130101) C12Q 2563/107 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101) C12Q 2565/514 (20130101) C12Q 2565/514 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) G01N 2458/10 (20130101)
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10227654 — Agents for reversing epigenetic silencing of genes

US 10227654	Nelson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	William G. Nelson (Towson, Maryland); Srinivasan Yegnasubramanian (Baltimore, Maryland); Xiaohui Lin (Redlands, California); Traci J. Speed (Baltimore, Maryland); Zachery Reichert (Baltimore, Maryland)
ABSTRACT	The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (MBD) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. Additionally, compounds identified by the present invention useful for treatment and prevention of diseases, such as cancer and sickle cell anemia, are provided.
FILED	Friday, May 08, 2015
APPL NO	14/708045
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/136 (20130101) A61K 31/381 (20130101) A61K 31/404 (20130101) A61K 31/433 (20130101) A61K 31/444 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/4184 (20130101) A61K 31/4188 (20130101) A61K 31/4245 (20130101) A61K 31/4439 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/136 (20130101) C12Q 2600/154 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/6875 (20130101) G01N 2500/00 (20130101)
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10227656 — Diagnostic/prognostic marker and therapeutic target for cancer

US 10227656	He et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Baylor College of Medicine (Houston, Texas)
ASSIGNEE(S)	Baylor College of Medicine (Houston, Texas)
INVENTOR(S)	Bin He (Bellaire, Texas); Rainer B. Lanz (Houston, Texas); Nicholas Mitsiades (Boston, Massachusetts); Qin Feng (Bellaire, Texas)
ABSTRACT	Embodiments of the present disclosure concern methods and compositions for prognosis, diagnosis, and/or treatment of prostate cancer or breast cancer, for example. Certain embodiments of the disclosure concern assaying for the expression level of TDRD1. Particular embodiments concern treating an individual with a particular cancer therapy when the expression level of TDRD1 is overexpressed.
FILED	Friday, November 07, 2014
APPL NO	15/034467
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5748 (20130101) G01N 33/57415 (20130101) G01N 33/57434 (20130101) G01N 33/57496 (20130101) G01N 2333/4703 (20130101)
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10227664 — Cedar virus and methods of use

US 10227664	Wang et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA)
APPLICANT(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The State of Queensland, Department of Agriculture, Fisheries and Forestry (Brisbane, Australia); Commonwealth Scientific and Industrial Research Organization (Clayton South, Australia)
INVENTOR(S)	Linfa Wang (Wandana Heights, Australia); Glenn A. Marsh (Leopold, Australia); Hume Field (Ormiston, Australia); Christopher Broder (Silver Springs, Maryland)
ABSTRACT	The present invention is directed towards a novel virus, called Cedar Virus, and its methods of use.
FILED	Monday, June 13, 2016
APPL NO	15/180544
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/12 (20130101) A61K 2039/543 (20130101) Peptides C07K 14/005 (20130101) C07K 16/1027 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/18221 (20130101) C12N 2760/18222 (20130101) C12N 2760/18231 (20130101) C12N 2760/18234 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/701 (20130101) Original (OR) Class C12Q 2600/136 (20130101)
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10228347 — High contrast signal to noise ratio device components

US 10228347	Barrall et al.
FUNDED BY	Department of Homeland Security (DHS) Science and Technology Directorate (DHS-ST) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	Geoffrey A. Barrall (San Diego, California); Eric N. Ervin (Salt Lake City, Utah); Prithwish Pal (San Diego, California)
ASSIGNEE(S)	Electronic BioSciences, Inc. (San Diego, California)
INVENTOR(S)	Geoffrey A. Barrall (San Diego, California); Eric N. Ervin (Salt Lake City, Utah); Prithwish Pal (San Diego, California)
ABSTRACT	Provided are device components, devices and methods characterized by a high contrast signal to noise ratio (CNR).
FILED	Friday, June 22, 2012
APPL NO	14/128587
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/447 (20130101) Original (OR) Class G01N 33/48721 (20130101)
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10228348 — Molecular characterization device

US 10228348	Branton et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Daniel Branton (Lexington, Massachusetts); Jene A Golovchenko (Lexington, Massachusetts)
ABSTRACT	Provided is a solid state support structure including an aperture having a molecular entrance and a molecular exit. A first reservoir is in fluidic communication with the molecular entrance of the aperture and contains a molecule-bearing liquid solution. A second reservoir is in fluidic communication with the molecular exit of the aperture for containing a molecule-bearing liquid solution. A first liquid channel is connected to the first reservoir within less than about 300 microns of the aperture in the support structure and includes molecule-bearing liquid solution for delivery to the first reservoir. A second liquid channel is connected to the second reservoir for accepting molecule-bearing liquid solution from the second reservoir. An electrical connection between the first reservoir and the second reservoir imposes an electrical bias between the first reservoir and the second reservoir for driving the molecule-bearing liquid solution through the aperture in the solid state support structure.
FILED	Friday, January 22, 2016
APPL NO	15/004248
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 2565/631 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44743 (20130101) G01N 27/44791 (20130101) Original (OR) Class G01N 33/48721 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/762 (20130101)
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10228372 — Detection, capture and quantification of biological moieties from unprocessed bodily fluids using nanoplasmonic platform

US 10228372	Demirci et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Utkan Demirci (Cambridge, Massachusetts); Fatih Inci (Cambridge, Massachusetts)
ASSIGNEE(S)	THE BRIGHAM AND WOMEN'S HOSPITAL (Boston, Massachusetts)
INVENTOR(S)	Utkan Demirci (Cambridge, Massachusetts); Fatih Inci (Cambridge, Massachusetts)
ABSTRACT	A nanoplasmonic platform can be used for the detection and quantification of multiple HIV subtypes in whole blood with localized surface plasmon resonance. Among other things, this nanoplasmonic platform provides a viable way to detection and quantification of viral load at a point of care with significantly less cost, time, and laboratory resources than existing methods of detection. Although an example of HIV detection in whole blood is provided, the nanoplasmonic platform is adaptable to detect other pathogens and infectious agents or macromolecules.
FILED	Wednesday, July 03, 2013
APPL NO	14/412767
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Peptides C07K 17/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/554 (20130101) G01N 33/5308 (20130101) G01N 33/6866 (20130101) G01N 33/54346 (20130101) G01N 33/54373 (20130101) G01N 33/56916 (20130101) G01N 33/56988 (20130101) Original (OR) Class G01N 2333/16 (20130101) G01N 2469/10 (20130101)
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10228374 — Antibodies with high affinity for alpha-Klotho

US 10228374	Sidhu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Governing Council of the University of Toronto (Toronto, Canada); Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	The Governng Council of the University of Toronto (, Canada); Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Sachdev S. Sidhu (Toronto, Canada); Sarah L. Barker (Toronto, Canada); Orson W. Moe (Dallas, Texas); Makoto Kuro-o (Dallas, Texas)
ABSTRACT	An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a αKlotho polypeptide, optionally a folded αKiotho or optionally with a dissociation constant (K_D) of about 2 nM or less, as measured by competitive ELISA assay, methods 0 of making and using to diagnose kidney diseases.
FILED	Friday, July 31, 2015
APPL NO	15/500478
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/71 (20130101) C07K 16/28 (20130101) C07K 16/40 (20130101) C07K 2317/51 (20130101) C07K 2317/56 (20130101) C07K 2317/92 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Enzymes C12Y 302/01031 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 33/6872 (20130101) G01N 2333/924 (20130101) G01N 2800/52 (20130101) G01N 2800/347 (20130101)
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10228376 — Diagnostic method for pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorder associated with streptococci infection (PANDAS)

US 10228376	Cunningham et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	Moleculera Labs, Inc. (Oklahoma City, Oklahoma); The Board of Regents of the University of Oklahoma (Norman, Oklahoma); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
ASSIGNEE(S)	Moleculera Labs, Inc. (Oklahoma City, Oklahoma); The Board of Regents of the University of Oklahoma (Oklahoma City, Oklahoma); The United States of America, As Represented by the Secretary, Department of Health and Human Serv (Washington, District of Columbia)
INVENTOR(S)	Phina Madeleine Cunningham (Oklahoma City, Oklahoma); Craig David Shimasaki (Edmond, Oklahoma); Susan E. Swedo (McLean, Virginia); Christine Kirvan (Lincoln, California)
ABSTRACT	The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (PANS) and/or pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) in an individual. These include enzyme linked immunosorbent assays (ELISAs) to measure antibody titers against neuronal antigens present in the brain; the neuronal antigens include lysoganglioside, tubulin, dopamine receptor D1, dopamine receptor D2, serotonin receptor 5HT2A, and serotonin receptor 5HT2C. Antibody titers against at least four of these neuronal antigens are required in the present methods; preferably antibody tiers against all of these neuronal antigens are measured. A final assay is used to quantify calcium/calmodulin-dependent protein kinase activity using a neuronal cell line. The results of these analyses or tests are then combined using an algorithm to determine whether a PANS or PANDAS diagnosis is appropriate for the individual. Depending on the diagnosis, an appropriate treatment can be determined.
FILED	Friday, October 13, 2017
APPL NO	15/783541
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 33/686 (20130101) Original (OR) Class G01N 33/6854 (20130101) G01N 33/6896 (20130101) G01N 33/56944 (20130101) G01N 2333/315 (20130101) G01N 2333/726 (20130101) G01N 2333/912 (20130101) G01N 2405/10 (20130101) G01N 2469/20 (20130101) G01N 2800/26 (20130101) G01N 2800/28 (20130101) G01N 2800/30 (20130101) G01N 2800/38 (20130101)
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10228378 — Diagnostic and therapeutic methods and products related to anxiety disorders

US 10228378	May et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	The University of Vermont and State Agricultural College (Burlington, Vermont); Emory University (Atlanta, Georgia)
ASSIGNEE(S)	The University of Vermont and State Agricultural College (Burlington, Vermont); Emory University (Atlanta, Georgia)
INVENTOR(S)	Victor May (Essex, Vermont); Kerry J. Ressler (Atlanta, Georgia); Sayamwong E. Hammack (Essex Junction, Vermont); Donna Toufexis (So. Burlington, Vermont); Karen M. Braas (Essex, Vermont)
ABSTRACT	The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.
FILED	Monday, June 05, 2017
APPL NO	15/614448
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/112 (20130101) C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2333/5757 (20130101) G01N 2800/301 (20130101)
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10228380 — Methods for targeting membrane steroid transporters

US 10228380	Yamanaka et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Naoki Yamanaka (Riverside, California); Sachiko Yamanaka (Riverside, California); Naoki Okamoto (Riverside, California); Riyan Bittar (South Pasadena, California)
ABSTRACT	Described herein are methods of identifying compounds that can modulate the transport of a steroid hormone across a phospholipid membrane. Also described herein are methods of identifying compounds that can affect the transcriptional activity of a steroid hormone nuclear receptor.
FILED	Thursday, February 22, 2018
APPL NO	15/902948
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/743 (20130101) Original (OR) Class G01N 2500/04 (20130101)
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10228434 — Multi-shot echo planar imaging using reordered segments and RF excitation pulse phase and slice profiles matched across interleaves

US 10228434	Polimeni et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Jonathan R Polimeni (Cambridge, Massachusetts); Thomas Witzel (Boston, Massachusetts)
ABSTRACT	Described here are systems and methods for producing images with a magnetic resonance imaging (“MRI”) system using a high-resolution, motion-robust, artifact-free segmented echo planar imaging (“EPI”) technique. In particular, a fast low angle excitation echo planar imaging technique (“FLEET”) using variable flip angle (“VFA”) radio frequency (“RF”) excitation pulses that are specifically designed to have a flat magnitude and phase profile across a slice for a range of different flip angles.
FILED	Wednesday, May 03, 2017
APPL NO	15/586005
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4833 (20130101) G01R 33/5616 (20130101) Original (OR) Class G01R 33/5659 (20130101)
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10228550 — Laser-based Fourier ptychographic imaging systems and methods

US 10228550	Ou et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) NIH Office of the Director (NIHOD)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Xiaoze Ou (Pasadena, California); Jaebum Chung (Pasadena, California); Changhuei Yang (South Pasadena, California)
ABSTRACT	Certain embodiments pertain to laser-based Fourier ptychographic (LFP) imaging systems, angle direction devices used in the LFP imaging systems, optical switches used in the LFP imaging systems, and LFP imaging methods. The LFP systems include an angle direction device for directing laser light to a sample plane at a plurality of illumination angles at different sample times. The LFP systems also include an optical system and a light detector. The optical system receives light issuing from the sample being imaged and propagates and focuses the light to the light detector acquiring raw intensity images.
FILED	Friday, May 20, 2016
APPL NO	15/160941
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8806 (20130101) G01N 21/8851 (20130101) G01N 2021/8822 (20130101) G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) Original (OR) Class G02B 21/0048 (20130101) G02B 21/086 (20130101) G02B 21/367 (20130101) G02B 26/101 (20130101) G02B 26/105 (20130101) Pictorial Communication, e.g Television H04N 5/2256 (20130101) H04N 7/18 (20130101)
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10229310 — High throughput partial wave spectroscopic microscopy and associated systems and methods

US 10229310	Backman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Vadim Backman (Evanston, Illinois); Hariharan Subramanian (Evanston, Illinois); John E. Chandler (Evanston, Illinois); Craig White (Evanston, Illinois); Jeremy D. Rogers (Evanston, Illinois); Lusik Cherkezyan (Evanston, Illinois)
ABSTRACT	The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (HT/A-PWS) instruments and systems capable of rapid acquisition of PWS Microscopic images and clinical, diagnostic, and research applications thereof.
FILED	Thursday, October 26, 2017
APPL NO	15/794101
ART UNIT	2483 — Recording and Compression
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/44 (20130101) G01J 3/1256 (20130101) G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/47 (20130101) G01N 2021/4709 (20130101) Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/16 (20130101) G02B 21/365 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00127 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/2354 (20130101) H04N 5/23212 (20130101)
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10229494 — Automated analysis of intravascular OCT image volumes

US 10229494	Lu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S)	Hong Lu (Somerville, Massachusetts); David L. Wilson (Cleveland Heights, Ohio); Hiram G. Bezerra (Cleveland, Ohio); Soumya Ray (Cleveland Heights, Ohio)
ABSTRACT	This disclosure provides systems and methods to automatically classify stent struts as covered or uncovered and to measure the thickness of tissue coverage. As one example, the method includes storing three-dimensional image data acquired intravascularly via an optical coherence tomography (OCT) apparatus and detecting struts based on analysis of the image data. Image data corresponding to each of the detected struts is further analyzed automatically to compute an indication of tissue coverage for the stent.
FILED	Thursday, September 22, 2016
APPL NO	15/273405
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/52 (20130101) G06K 9/4604 (20130101) G06K 9/6215 (20130101) G06K 9/6218 (20130101) G06K 9/6269 (20130101) G06K 2009/4666 (20130101) G06K 2209/051 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/62 (20170101) G06T 7/77 (20170101) G06T 7/155 (20170101) G06T 2207/10101 (20130101) G06T 2207/20072 (20130101) G06T 2207/20081 (20130101) G06T 2207/20092 (20130101) G06T 2207/30052 (20130101) G06T 2207/30101 (20130101)
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10230208 — High-energy femtosecond light pulses based on a gain-switched laser diode

US 10230208	Fu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF)
APPLICANT(S)	Cornell University (Ithaca, New York)
ASSIGNEE(S)	Cornell University (Ithaca, New York)
INVENTOR(S)	Walter Fu (Ithaca, New York); Frank W. Wise (Ithaca, New York); Logan Wright (Ithaca, New York)
ABSTRACT	This disclosed subject matter allows short pulses with high peak powers to be obtained from seed pulses generated by a gain-switched diode. The gain-switched diode provides a highly stable source for optical systems such as nonlinear microscopy. The disclosed system preserves the ability to generate pulses at arbitrary repetition rates, or even pulses on demand, which can help reduce sample damage in microscopy experiments or control deliberate damage in material processing.
FILED	Wednesday, March 28, 2018
APPL NO	15/939250
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3526 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/06725 (20130101) H01S 3/06741 (20130101) H01S 3/06754 (20130101) H01S 3/08013 (20130101) Original (OR) Class H01S 5/0057 (20130101) H01S 5/0078 (20130101) H01S 5/0428 (20130101) H01S 5/0656 (20130101) H01S 2301/08 (20130101)
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10230943 — Goggle imaging systems and methods

US 10230943	Achilefu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Washington University (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Samuel Achilefu (St. Louis, Missouri); Yang Liu (Akron, Ohio); Viktor Gruev (St. Louis, Missouri); Joseph P. Culver (Webster Groves, Missouri); Walter Akers (Columbia, Illinois); Adam Bauer (Webster Groves, Missouri)
ABSTRACT	A goggle system is provided. The goggle system includes a computing device, a goggle device configured to be worn by a user and including a detector configured to simultaneously acquire image data of a subject in a first image mode and a second image mode, at least one eye assembly configured to display at least one of an image in the first image mode, an image in the second image mode, and a hybrid image including pixels of image data from the first image mode and pixels of image data from the second image mode, and a communications module configured to transmit acquired image data from the goggle device to the computing device.
FILED	Wednesday, January 23, 2013
APPL NO	14/374002
ART UNIT	2628 — Selective Visual Display Systems
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/0005 (20130101) A61B 1/0692 (20130101) A61B 34/25 (20160201) A61B 90/30 (20160201) A61B 90/36 (20160201) A61B 90/361 (20160201) A61B 2090/364 (20160201) Optical Elements, Systems, or Apparatus G02B 27/017 (20130101) Pictorial Communication, e.g Television H04N 5/374 (20130101) H04N 13/344 (20180501) Original (OR) Class
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Department of Defense (DOD)

10226194 — Statistical, noninvasive measurement of a patient's physiological state

US 10226194	Grudic et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)	Flashback Technologies, Inc. (Louisville, Colorado)
INVENTOR(S)	Gregory Zlatko Grudic (Niwot, Colorado); Steven Lee Moulton (Littleton, Colorado); Isobel Jane Mulligan (Niwot, Colorado)
ABSTRACT	Tools and techniques for the rapid, continuous, invasive and/or noninvasive measurement, estimation, and/or prediction of a patient's physiological state. In an aspect, some tools and techniques can estimate predict the onset of conditions intracranial pressure, an amount of blood volume loss, cardiovascular collapse, and/or dehydration. Some tools can recommend (and, in some cases, administer) a therapeutic treatment for the patient's condition. In another aspect, some techniques employ high speed software technology that enables active, long term learning from extremely large, continually changing datasets. In some cases, this technology utilizes feature extraction, state-of-the-art machine learning and/or statistical methods to autonomously build and apply relevant models in real-time.
FILED	Monday, September 28, 2015
APPL NO	14/867938
ART UNIT	3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/021 (20130101) A61B 5/031 (20130101) Original (OR) Class A61B 5/0205 (20130101) A61B 5/0402 (20130101) A61B 5/742 (20130101) A61B 5/0836 (20130101) A61B 5/02108 (20130101) A61B 5/02405 (20130101) A61B 5/02416 (20130101) A61B 5/4261 (20130101) A61B 5/4839 (20130101) A61B 5/14542 (20130101) A61B 5/14551 (20130101) A61B 8/488 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) G06F 19/3481 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101) G16H 50/50 (20180101)
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10226361 — Quasi passive assistive device

US 10226361	Mooney et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	REHABILITATION INSTITUTE OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)	Rehabilitation Institute of Chicago (Chicago, Illinois)
INVENTOR(S)	Luke M. Mooney (Westford, Massachusetts); Elliott J. Rouse (Chicago, Illinois)
ABSTRACT	Implementations of a quasi-passive assistive device are disclosed. Such a device may comprise a spring mechanism that increases stiffness similar to a biological ankle. In one implementation, the spring mechanism may comprise a piston, valve, springs, or other elements to match a biological stiffness profile similar to that of a biological ankle. In one implementation, an apparatus for an artificial ankle is disclosed, comprising a piston coupled to a spring and the piston connected to a valve. The spring and the piston may store energy during dorsiflexion of the ankle and the spring and the piston release energy during plantarflexion of the ankle. The piston may store and release energy through the use of the valve.
FILED	Thursday, August 25, 2016
APPL NO	15/247531
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/68 (20130101) A61F 2/6607 (20130101) Original (OR) Class A61F 2002/747 (20130101) A61F 2002/748 (20130101) A61F 2002/5006 (20130101) A61F 2002/5079 (20130101) A61F 2002/6657 (20130101)
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10226439 — Small molecule inhibitors of STAT3 with anti-tumor activity

US 10226439	Turkson et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
ASSIGNEE(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
INVENTOR(S)	James Turkson (Honolulu, Hawaii); Said M. Sebti (Tampa, Florida); Wayne Guida (St. Petersburg Beach, Florida); Man Lun Yip (Monrovia, California); Nicholas Lawrence (Tampa, Florida); Harshani Rithma Lawrence (Tampa, Florida); Benjamin Greedy (Somerset, United Kingdom)
ABSTRACT	The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis. The invention further includes an in-vitro screening test for the presence of malignant cells in a mammalian tissue; a method of identifying inhibitors of constitutive Stat3 activation, Stat3-DNA binding, Stat5-DNA binding, and/or Stat3 dimerization; and a method of identifying anti-cancer agents.
FILED	Friday, March 24, 2017
APPL NO	15/468460
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/18 (20130101) A61K 31/18 (20130101) A61K 31/196 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2300/00 (20130101) Acyclic or Carbocyclic Compounds C07C 235/84 (20130101) C07C 309/73 (20130101) C07C 311/19 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5011 (20130101) G01N 33/5088 (20130101) G01N 33/57407 (20130101) G01N 33/57484 (20130101)
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10226483 — Topical compositions and methods of using the same

US 10226483	Doxey et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Novan, Inc. (Morrisville, North Carolina)
ASSIGNEE(S)	Novan, Inc. (Morrisville, North Carolina)
INVENTOR(S)	Ryan Doxey (Raleigh, North Carolina); Jian Bao (Cary, North Carolina)
ABSTRACT	The present invention generally relates to topical compositions and methods of using the same. The topical compositions may comprise a hydrophilic composition and a hydrophobic composition in admixture. The hydrophobic composition may include a nitric oxide-releasing compound such as, for example, a diazeniumdiolate functionalized co-condensed silica particle. In some embodiments, the topical composition may be self-emulsifying. Further described herein are kits comprising a hydrophilic composition and a hydrophobic composition.
FILED	Wednesday, May 02, 2018
APPL NO	15/969628
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 8/25 (20130101) A61K 8/042 (20130101) A61K 8/345 (20130101) A61K 8/898 (20130101) A61K 9/06 (20130101) A61K 9/10 (20130101) A61K 9/0014 (20130101) A61K 9/107 (20130101) A61K 33/00 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 47/10 (20130101) A61K 47/12 (20130101) A61K 47/14 (20130101) A61K 47/32 (20130101) A61K 47/38 (20130101) A61K 47/44 (20130101) A61K 47/52 (20170801) A61K 47/59 (20170801) A61K 2800/22 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/005 (20130101) A61Q 19/00 (20130101)
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10226759 — Overpotential and selectivity in the electrochemical conversion of CO₂into fuels

US 10226759	Peterson et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	BROWN UNIVERSITY (Providence, Rhode Island)
ASSIGNEE(S)	Brown University (Providence, Rhode Island)
INVENTOR(S)	Andrew Peterson (Providence, Rhode Island); Yin-Jia Zhang (Providence, Rhode Island); Seok Ki Kim (Providence, Rhode Island)
ABSTRACT	The invention provides a catalyst and method for producing hydrocarbons from a carbon dioxide source comprising carbides, in particular one or more metal carbides. The one or more metal carbides are formed with one or more elements selected from the group consisting of molybdenum, titanium, tungsten, iron, and tantalum. In one embodiment, the one or more metal carbides are nanostructures. In another embodiment, the one or more metal carbide nanostructures are supported by a carbon substrate. In a further embodiment, the one or more metal carbides nanostructures is dimolybdenum carbide. In still another embodiment, the carbon substrate is graphene or graphene oxide. In another embodiment, the dimolybdenum carbide nanostructures are supported by the graphene or graphene oxide substrate.
FILED	Thursday, September 10, 2015
APPL NO	14/850752
ART UNIT	1622 — Organic Chemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) B01J 27/22 (20130101) Original (OR) Class B01J 35/0013 (20130101) B01J 35/0033 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/914 (20170801) C01B 32/921 (20170801) C01B 32/949 (20170801) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 2/50 (20130101) C10G 2/332 (20130101)
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10226769 — Method and device for high-throughput solution exchange for cell and particle suspensions

US 10226769	Di Carlo et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Dino Di Carlo (Los Angeles, California); Daniel R. Gossett (Los Angeles, California); Henry T. K. Tse (San Francisco, California)
ABSTRACT	A method of exchanging fluids with suspended particles includes providing a microfluidic device with a first inlet channel operatively coupled to a source of particles and a second inlet channel operatively coupled to an exchange fluid. A transfer channel is connected at a proximal end to the first inlet channel and the second inlet channel. First and second outlet channels are connected to a distal end of the transfer channel. The source of particles is flowed at a first flow rate into the first inlet channel while the exchange fluid is flowed at a second flow rate into the second inlet channel wherein the ratio of the second flow rate to the first flow rate is at least 1.5. Particles are collected in one of the first and second outlet channels while fluid substantially free of particles is collected in the other of the first and second outlet channels.
FILED	Monday, October 16, 2017
APPL NO	15/785191
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 12/00 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) B01L 3/502761 (20130101) B01L 3/502776 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2400/084 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2015/149 (20130101)
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10226869 — Haptic virtual fixture tools

US 10226869	Chizeck et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington)
ASSIGNEE(S)	University of Washington (Seattle, Washington)
INVENTOR(S)	Howard Jay Chizeck (Seattle, Washington); Andrew Stewart (Seattle, Washington); Fredrik Ryden (Seattle, Washington)
ABSTRACT	Apparatus and methods for defining and utilizing virtual fixtures for haptic navigation within real-world environments, including underwater environments, are provided. A computing device can determine a real-world object within a real-world environment. The computing device can receive an indication of the real-world object. The computing device can determine a virtual fixture that corresponds to the real-world object based on the indication, where aspects of the virtual fixture are configured to align with aspects of the real-world object. The computing device can provide a virtual environment for manipulating the robotic tool to operate on the real-world object utilizing the virtual fixture. The virtual fixture is configured to provide haptic feedback based on a position of a virtual robotic tool in the virtual environment that corresponds to the robotic tool in the real-world environment.
FILED	Monday, March 02, 2015
APPL NO	15/123394
ART UNIT	3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Manipulators; Chambers Provided With Manipulation Devices B25J 9/1689 (20130101) Original (OR) Class Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/427 (20130101) G05B 2219/40122 (20130101)
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10226870 — Yaw slip handling in a robotic device

US 10226870	Silva et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA)
APPLICANT(S)	Boston Dynamics, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	Boston Dynamics, Inc. (Waltham, Massachusetts)
INVENTOR(S)	Marco Da Silva (Arlington, Massachusetts); Kevin Blankespoor (Arlington, Massachusetts); Michael Scott Rose (Arlington, Massachusetts)
ABSTRACT	An example method may include determining a requested yaw for a body of a robot, where the biped robot comprises a foot coupled to the body via a leg. The robot may then detect, via one or more sensors, a yaw rotation of the body with respect to a ground surface, where the foot is in contact with the ground surface. Based on the detected yaw rotation of the body, the robot may determine a measured yaw for the body. The robot may also determine a target yaw for the body, where the target yaw for the body is between the measured yaw for the body and the requested yaw for the body. The robot may then cause the foot to rotate the body to the target yaw for the body.
FILED	Monday, March 06, 2017
APPL NO	15/450977
ART UNIT	3663 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Manipulators; Chambers Provided With Manipulation Devices B25J 9/0003 (20130101) B25J 13/085 (20130101) B25J 13/088 (20130101) Original (OR) Class Motor Vehicles; Trailers B62D 57/032 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/5705 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0891 (20130101) G05D 2201/0217 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/01 (20130101)
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10226891 — Methods, system and apparatuses for in situ removal of window distortion

US 10226891	Sterling et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	THE BOEING COMPANY (Chicago, Illinois)
ASSIGNEE(S)	THE BOEING COMPANY (Chicago, Illinois)
INVENTOR(S)	Tyler R. Sterling (Bellevue, Washington); Garrett Murdock Myhre (Seattle, Washington); Thanh Dac Tran (Seattle, Washington); John Robert Lesh, Jr. (Woodinville, Washington)
ABSTRACT	Methods systems and apparatuses for reducing or substantially eliminating distortion in a transparent substrate in situ are disclosed.
FILED	Monday, August 01, 2016
APPL NO	15/225013
ART UNIT	1715 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 35/0288 (20130101) B29C 51/46 (20130101) B29C 51/421 (20130101) Original (OR) Class B29C 71/02 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2101/10 (20130101) B29K 2105/256 (20130101) B29K 2995/0026 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/778 (20130101) B29L 2031/3052 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 17/10963 (20130101) B32B 2369/00 (20130101) Aeroplanes; Helicopters B64C 1/1476 (20130101) B64C 1/1484 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/40 (20170101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/00 (20130101) G01C 23/005 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0607 (20130101)
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10226905 — Material tensioning system

US 10226905	Matlack et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	the boeing company (chicago, Illinois)
INVENTOR(S)	Mike P. Matlack (St. Charles, Missouri); Stephen J. Morgan (Cypress, California); Thomas K. Tsotsis (Santa Ana, California); James R. Fox (University City, Missouri); Randall D. Wilkerson (O'Fallon, Missouri)
ABSTRACT	A system and method for forming an item from a material, which may include elongated fibers and/or stretched broken fibers. The material is placed on a first clamping portion, which is placed on a fixture. A second clamping portion is placed against the material and the first clamping portion and secured together, forming a clamping assembly. The clamping assembly is removed from the fixture and placed on a first die portion, having a first profile. A second die portion is also provided, having a second profile. In forming the item, at least one of the first die portion and the second die portion are moved toward each other such that a second surface of the first die portion and a first surface of the second die portion contact and form the material into the item generally replicating the first profile and the second profile.
FILED	Tuesday, September 22, 2015
APPL NO	14/861158
ART UNIT	1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 51/004 (20130101) B29C 51/082 (20130101) B29C 51/262 (20130101) B29C 51/264 (20130101) B29C 70/46 (20130101) B29C 70/56 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2101/12 (20130101) B29K 2105/14 (20130101)
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10227581 — Engineered transcription activator-like effector (TALE) domains and uses thereof

US 10227581	Liu et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	David R. Liu (Lexington, Massachusetts); John Paul Guilinger (Ridgway, Colorado); Vikram Pattanayak (Cambridge, Massachusetts)
ABSTRACT	Engineered transcriptional activator-like effectors (TALEs) are versatile tools for genome manipulation with applications in research and clinical contexts. One current drawback of TALEs is their tendency to bind and cleave off-target sequence, which hampers their clinical application and renders applications requiring high-fidelity binding unfeasible. This disclosure provides engineered TALE domains and TALEs comprising such engineered domains, e.g., TALE nucleases (TALENs), TALE transcriptional activators, TALE transcriptional repressors, and TALE epigenetic modification enzymes, with improved specificity and methods for generating and using such TALEs.
FILED	Friday, August 22, 2014
APPL NO	14/913458
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 2319/00 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/01 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Enzymes C12Y 301/00 (20130101)
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10227664 — Cedar virus and methods of use

US 10227664	Wang et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA)
APPLICANT(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The State of Queensland, Department of Agriculture, Fisheries and Forestry (Brisbane, Australia); Commonwealth Scientific and Industrial Research Organization (Clayton South, Australia)
INVENTOR(S)	Linfa Wang (Wandana Heights, Australia); Glenn A. Marsh (Leopold, Australia); Hume Field (Ormiston, Australia); Christopher Broder (Silver Springs, Maryland)
ABSTRACT	The present invention is directed towards a novel virus, called Cedar Virus, and its methods of use.
FILED	Monday, June 13, 2016
APPL NO	15/180544
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/12 (20130101) A61K 2039/543 (20130101) Peptides C07K 14/005 (20130101) C07K 16/1027 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/18221 (20130101) C12N 2760/18222 (20130101) C12N 2760/18231 (20130101) C12N 2760/18234 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/701 (20130101) Original (OR) Class C12Q 2600/136 (20130101)
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10227804 — Deployable joint

US 10227804	Howell et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Engineering (ENG) Office of Emerging Frontiers in Research and Innovation (EFRI)
APPLICANT(S)	BRIGHAM YOUNG UNIVERSITY (Provo, Utah)
ASSIGNEE(S)	Brigham Young University (Provo, Utah)
INVENTOR(S)	Larry L. Howell (Orem, Utah); Todd Nelson (Provo, Utah)
ABSTRACT	According to an aspect, a device may include a deployable rolling joint having a first deployable joint member, a second deployable joint member, and a plurality of flexures coupled to the first deployable joint member and the second deployable joint member. The deployable rolling joint may move from an undeployed state to a deployed state in which the first deployable joint member forms a convex surface portion and the second deployable joint member forms a convex surface portion. When the deployable rolling joint is in the deployed state, the convex surface portion of the first deployable joint member may roll with respect the convex surface portion of the second deployable joint member, and the plurality of flexures may hold the first deployable joint member and the second deployable joint member together as the first deployable joint member and the second deployable joint member roll across each other.
FILED	Tuesday, December 15, 2015
APPL NO	14/969979
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/30 (20130101) A61F 2002/30092 (20130101) Hinges or Suspension Devices for Doors, Windows or Wings E05D 1/00 (20130101) E05D 1/04 (20130101) Original (OR) Class Indexing Scheme Relating to Hinges or Other Suspension Devices for Doors, Windows or Wings and Devices for Moving Wings into Open or Closed Position, Checks for Wings and Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing E05Y 2800/00 (20130101) E05Y 2900/60 (20130101) E05Y 2900/502 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 11/04 (20130101)
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10227952 — Gas path liner for a gas turbine engine

US 10227952	Kramer
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Department of the Navy (DON) Naval Air Systems Command (NAVAIR)
APPLICANT(S)	George J. Kramer (Tolland, Connecticut)
ASSIGNEE(S)	United Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	George J. Kramer (Tolland, Connecticut)
ABSTRACT	An exhaust nozzle for a gas turbine engine includes a gas path liner connected to an interior surface of an exhaust nozzle flap. The gas path liner includes a liner backbone that extends along a liner axis, and a plurality of liner panels sequentially connected to the liner backbone along the axis. Each liner panel includes a panel length that extends axially from a first panel end to a second panel end, where the panel length thermally expands independent of the liner backbone
FILED	Friday, September 30, 2011
APPL NO	13/250358
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Jet-propulsion Plants F02K 1/12 (20130101) F02K 1/80 (20130101) F02K 1/82 (20130101) F02K 1/805 (20130101) Original (OR) Class
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10228023 — Bearing outer race oil supply for thin film fluidic damping

US 10228023	Clark et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Hartford, Connecticut)
ASSIGNEE(S)	United Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Thomas E. Clark (Sanford, Maine); Eric Charles Mundell (South Berwick, Maine); Gary L. Grogg (South Berwick, Maine)
ABSTRACT	An improved film damper oil delivery pathway from an oil reservoir to a thin film fluidic damper is provided. An oil supply tube may be configured to mate to a bearing outer race. The bearing outer race may comprise internal oil flow circuit(s) configured to supply oil from the oil tube to the thin film damper for improved bearing compartment designs.
FILED	Tuesday, March 22, 2016
APPL NO	15/076783
ART UNIT	3656 — Material and Article Handling
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/164 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 19/26 (20130101) F16C 27/045 (20130101) F16C 33/581 (20130101) F16C 33/6677 (20130101) Original (OR) Class F16C 2360/23 (20130101) Springs; Shock-absorbers; Means for Damping Vibration F16F 15/0237 (20130101)
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10228136 — Combustor assembly

US 10228136	Hannwacker et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	David Andrew Hannwacker (Torrance, California); Stephen John Howell (West Newbury, Massachusetts)
ABSTRACT	A combustor assembly for a gas turbine engine is includes a liner and a combustor dome formed of a ceramic matrix composite material. The combustor dome and liner together define at least in part a combustion chamber. The combustor dome extends along a circumferential direction and defines one or more openings, the combustor dome is configured to receive one or more fuel-air injector hardware assemblies in or through the one or more openings.
FILED	Thursday, February 25, 2016
APPL NO	15/053398
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/18 (20130101) Casings, Linings, Walls or Doors Specially Adapted for Combustion Chambers, e.g Firebridges; Devices for Deflecting Air, Flames or Combustion Products in Combustion Chambers; Safety Arrangements Specially Adapted for Combustion Apparatus; Details of Combustion Chambers, Not Otherwise Provided for F23M 2900/05004 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/04 (20130101) F23R 3/007 (20130101) Original (OR) Class F23R 3/10 (20130101) F23R 3/50 (20130101) F23R 3/286 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/675 (20130101)
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10228223 — Cook-off mitigation systems

US 10228223	Hardt et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Lee R. Hardt (Ridgecrest, California); Donald L. Burnett (Spearfish, South Dakota); Josiah S. Garfield (Ridgecrest, California); Robert A. Koontz (Anchorage, Alaska)
ABSTRACT	Embodiments of the invention are directed to enhancing insensitive munitions performance. Some embodiments of the invention employ an outgassing pad having unique geometrical configurations and positioning. Other embodiments rely on using thermally-releasable components to foster billet expulsion. Additional embodiments combine both aspects into an entire cook-off mitigation system.
FILED	Wednesday, March 28, 2018
APPL NO	15/938518
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/20 (20130101) F42B 12/22 (20130101) F42B 12/207 (20130101) Original (OR) Class F42B 39/14 (20130101) F42B 39/20 (20130101) Ammunition Fuzes; Arming or Safety Means Therefor F42C 19/02 (20130101)
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10228277 — System and method to detect signatures from an underwater object

US 10228277	Land et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Phillip P. Land (Ridgecrest, California); Arun K. Majumdar (Oxnard, California)
ABSTRACT	Embodiments of the invention are directed to detecting an underwater object from an air-based system. The air-based system is associated with at least one controller. A broadband acousto-optic signal detection device is associated with the air-based platform. The broadband acousto-optic signal detection device is configured to emit a laser beam at an underwater object. The laser beam terminates at the underwater object and reflects back as a return laser beam. The broadband acousto-optic signal detection device is configured to detect and receive the return laser beam.
FILED	Friday, December 09, 2016
APPL NO	15/374298
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/00 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/04 (20130101) G01S 15/025 (20130101) G01S 17/023 (20130101) G01S 17/026 (20130101)
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10228284 — Devices and methods for sensing targets using photothermal speckle detection

US 10228284	Jeys et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Thomas H. Jeys (Lexington, Massachusetts); William D. Herzog (Bedford, Massachusetts); Brian G. Saar (Cambridge, Massachusetts); Alexander M. Stolyarov (Belmont, Massachusetts); Ryan Sullenberger (Lexington, Massachusetts); David Crompton (Lowell, Massachusetts); Shawn Michael Redmond (Lexington, Massachusetts)
ABSTRACT	A device, and corresponding method, can include a pump light source configured to be modulated at a pump modulation and to irradiate a target specimen. The device can also include a probe light source arranged to generate a speckle pattern from the target specimen, as well as a sensor configured to detect changes in at least one of position and intensity of one or more speckle lobes of the speckle pattern having correlation with the pump modulation. The device and method can be used for non-contact monitoring and remote sensing of surfaces, gases, liquids, particles, and other target materials by analyzing speckle pattern changes as a function of pump light irradiation. Advantages can include much higher sensitivity than existing methods; the ability to use visible probe wavelengths for uncooled, low-cost visible detectors with high spatial resolution; and the ability to obtain target material properties without detecting infrared light.
FILED	Monday, June 20, 2016
APPL NO	15/186682
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/108 (20130101) G01J 3/433 (20130101) Original (OR) Class G01J 3/447 (20130101) G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/636 (20130101) G01N 21/1717 (20130101) G01N 2021/1725 (20130101)
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10228313 — System and method for multiplexed affinity purification of proteins and cells

US 10228313	Sarkar et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); The Massachusetts General Hospital (Boston, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); The Massachusetts General Hospital (Boston, Massachusetts)
INVENTOR(S)	Aniruddh Sarkar (Cambridge, Massachusetts); Han Wei Hou (Singapore, Singapore); Jongyoon Han (Bedford, Massachusetts); Galit Alter (Winchester, Massachusetts)
ABSTRACT	In accordance with an embodiment of the invention, there is provided a method for: a) high-throughput, multiplexed, affinity-based separation of proteins—especially low abundance proteins—from complex biological mixtures such as serum; and b) high-throughput, multiplexed, affinity-based separation of cells—especially rare cells—from complex biological mixtures such as blood or blood fractions. The separation of proteins or cells is achieved based on differential binding to affinity-capture beads of different sizes and then sorting the protein-bound or cell-bound beads using the concept of centrifugal-induced Dean migration in a spiral microfluidic device. This method enables continuous-flow, high throughput affinity-separation of milligram-scale protein samples or millions of cells in minutes after binding. This is particularly applicable to the isolation of antigen-specific antibodies from polyclonal sera and antigen-specific immune cells or circulating tumor cells from blood, both of which are otherwise highly labor-intensive and expensive to perform.
FILED	Friday, October 23, 2015
APPL NO	15/520176
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502761 (20130101) B01L 3/502776 (20130101) B01L 2200/0652 (20130101) B01L 2300/088 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2400/0409 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) Original (OR) Class
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10228372 — Detection, capture and quantification of biological moieties from unprocessed bodily fluids using nanoplasmonic platform

US 10228372	Demirci et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Utkan Demirci (Cambridge, Massachusetts); Fatih Inci (Cambridge, Massachusetts)
ASSIGNEE(S)	THE BRIGHAM AND WOMEN'S HOSPITAL (Boston, Massachusetts)
INVENTOR(S)	Utkan Demirci (Cambridge, Massachusetts); Fatih Inci (Cambridge, Massachusetts)
ABSTRACT	A nanoplasmonic platform can be used for the detection and quantification of multiple HIV subtypes in whole blood with localized surface plasmon resonance. Among other things, this nanoplasmonic platform provides a viable way to detection and quantification of viral load at a point of care with significantly less cost, time, and laboratory resources than existing methods of detection. Although an example of HIV detection in whole blood is provided, the nanoplasmonic platform is adaptable to detect other pathogens and infectious agents or macromolecules.
FILED	Wednesday, July 03, 2013
APPL NO	14/412767
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Peptides C07K 17/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/554 (20130101) G01N 33/5308 (20130101) G01N 33/6866 (20130101) G01N 33/54346 (20130101) G01N 33/54373 (20130101) G01N 33/56916 (20130101) G01N 33/56988 (20130101) Original (OR) Class G01N 2333/16 (20130101) G01N 2469/10 (20130101)
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10228448 — Variable resource allocation for localization

US 10228448	Win et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Moe Z. Win (Framingham, Massachusetts); Wenhan Dai (Cambridge, Massachusetts); Yuan Shen (Allston, Massachusetts)
ASSIGNEE(S)	Massachusettts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Moe Z. Win (Framingham, Massachusetts); Wenhan Dai (Cambridge, Massachusetts); Yuan Shen (Allston, Massachusetts)
ABSTRACT	A method for localizing one or more devices in an environment make use of repeated allocation of resources for one or more sensor measurements. Each sensor measurement is characterized by the amount of resources allocated to the measurement, by a quality factor, and by direction-dependent characteristics of information that is obtainable from that sensor measurement. Knowledge of a current location of each of the one or more devices determined from past sensor measurements is characterized by a distribution, with each of the distribution containing information about the current location of the device, including the direction-dependent information and the uncertainty of the location. The allocation of resources makes use of the quality factors and direction-dependent characteristics of the sensor measurements, in combination with the distributions characterizing the current location of each of the one or more devices to allocate a variable amount of a resource to each of the one or more sensor measurements.
FILED	Monday, March 07, 2016
APPL NO	15/062586
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/14 (20130101) Original (OR) Class G01S 5/0278 (20130101)
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10228449 — Method and system for jointly separating noise from signals

US 10228449	Nguyen et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Lam H. Nguyen (Laurel, Maryland); Trac D. Tran (Ellicott City, Maryland)
ABSTRACT	A system for reception of electromagnetic waves in a spectrum in which interference with radio frequencies of other electronics devices occurs comprising a transmitter; at least one receiver configured to receive the received signal; each received signal organized into a digital vector; at least one memory portion configured to store a plurality of received signals in a vector form; the vectors being combined into a matrix, each vector of the matrix being a digital data record representing a received signal; at least one processor operatively connected to the at least one memory portion; the at least one processor configured to estimate that portion of the received signal attributable to noise; the at least one processor operating to jointly estimate a minimal number of distinctive noise patterns and minimize the simplicity of the data of interest; the at least processor operating to process the noise and data of interest separately.
FILED	Tuesday, June 07, 2016
APPL NO	15/175886
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/023 (20130101) Original (OR) Class G01S 13/90 (20130101) G01S 13/0209 (20130101) Transmission H04B 1/71632 (20130101) H04B 17/345 (20150115) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/0004 (20130101)
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10228527 — Gimbal transmission cable management

US 10228527	Chin et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Patricia D. Chin (Redondo Beach, California); John D. Isker (Sun City, California)
ABSTRACT	A gimbal transmission cable management system is disclosed. The system can include a first gimbal portion and a second gimbal portion rotatable relative to one another to provide rotation about a gimbal axis. The system can also include a cable retainer fixed relative to one of the first and second gimbal portions and defining a cable volume between the cable retainer and at least one of the first and second gimbal portions. In addition, the system can include a transmission cable coiled about the gimbal axis within the cable volume. Bi-directional relative rotation of the first and second gimbal portions can alternately coil and uncoil a portion of the transmission cable about the gimbal axis within the cable volume.
FILED	Friday, September 25, 2015
APPL NO	14/866530
ART UNIT	3632 — Static Structures, Supports and Furniture
CURRENT CPC	Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 3/16 (20130101) Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/022 (20130101) Weapon Sights; Aiming F41G 7/2213 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/003 (20130101) G01S 7/4818 (20130101) Optical Elements, Systems, or Apparatus G02B 6/4457 (20130101) G02B 6/4478 (20130101) Original (OR) Class Installation of Electric Cables or Lines, or of Combined Optical and Electric Cables or Lines H02G 3/04 (20130101)
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10228568 — Photostructured optical devices and methods for making same

US 10228568	Helvajian
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	THE AEROSPACE CORPORATION (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Henry Helvajian (Pasadena, California)
ABSTRACT	A photostructurable ceramic is processed using photostructuring process steps for embedding devices within a photostructurable ceramic volume, the devices including chemical, mechanical, electronic, electromagnetic, optical, and acoustic devices, all made in part by creating device material within the ceramic or by disposing a device material through surface ports of the ceramic volume, with the devices being interconnected using internal connections and surface interfaces.
FILED	Monday, August 31, 2015
APPL NO	14/841031
ART UNIT	1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 5/0236 (20130101) G02B 5/0268 (20130101) G02B 5/1852 (20130101) G02B 6/105 (20130101) G02B 7/00 (20130101) G02B 27/142 (20130101) Original (OR) Class G02B 27/1073 (20130101) G02B 2006/12035 (20130101) G02B 2006/12171 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/011 (20130101)
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10228666 — Material modification assembly and method for use in the modification of material substrates

US 10228666	Livingston et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	The Aerospace Corporation (El Segundo, California); Amendia Inc. (Marietta, Georgia)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Frank Edward Livingston (Redondo Beach, California); Timothy Ganey (Tampa, Florida)
ABSTRACT	A material modification assembly comprises an energy source for generating light beams to modify a substrate. A computing device generates pattern script(s) based on at least one parameter of the modification. The computing device also generates process script(s) including a type of pulse scripts to be used with the light beams and are based on at least one parameter of the interaction between the energy source and the substrate. The computing device combines the pattern script(s) with the process script(s) and generates command signals based on the combination. The computing device transmits the command signals to one or more additional devices of the material modification assembly to facilitate modifying the light beams for the modification to the substrate such that the modification includes a pattern on at least a surface of the substrate having dimensions and includes two or more discrete material alterations or changes spatially overlapped within the pattern.
FILED	Friday, January 24, 2014
APPL NO	14/163712
ART UNIT	2118 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/30771 (20130101) A61F 2002/3097 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Original (OR) Class
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10229068 — Tunable oblivious RAM

US 10229068	Wagh et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Sameer Wagh (Princeton, New Jersey); Paul Cuff (Lawrenceville, New Jersey); Prateek Mittal (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Sameer Wagh (Princeton, New Jersey); Paul Cuff (Lawrenceville, New Jersey); Prateek Mittal (Princeton, New Jersey)
ABSTRACT	An approach to implementing or configuring an Oblivious RAM (ORAM), which in addition to behaving as a RAM, provides a way to meet a specified degree of privacy in a manner that avoids applying unnecessary computation resources (computation time and/or storages space and/or data transfer) to achieve the specified degree of privacy. In this way, a tradeoff between privacy and computation resources may be tuned to address requirements of a particular application. This ability to tune this tradeoff is not found in other ORAM implementations, which in general aim to achieve complete privacy. In some implementations, the ORAM provides a constant bandwidth overhead compared to conventional RAMs, while achieving a statistical privacy as desired by the user.
FILED	Thursday, December 29, 2016
APPL NO	15/393822
ART UNIT	2136 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 12/1408 (20130101) Original (OR) Class G06F 21/00 (20130101) G06F 21/6245 (20130101) G06F 2212/402 (20130101)
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10229366 — Optimizing physical parameters in fault-tolerant quantum computing to reduce frequency crowding

US 10229366	Gambetta et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Jay M. Gambetta (Yorktown Heights, New York); Easwar Magesan (Yorktown Heights, New York)
ABSTRACT	A technique relates to quantum error correction. Code qubits are configured as target qubits, and the code qubits have a first dephasing time and a first anharmonicity. Syndrome qubits are configured as control qubits, and the syndrome qubits have a second dephasing time and a second anharmonicity. The target qubits and the control qubits are configured to form one or more controlled not (CNOT) gates. The first dephasing time is greater than the second dephasing time and the second anharmonicity is greater than the first anharmonicity.
FILED	Wednesday, February 14, 2018
APPL NO	15/896651
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 99/00 (20130101) G06N 99/002 (20130101) Original (OR) Class Pulse Technique H03K 19/00346 (20130101) Coding; Decoding; Code Conversion in General H03M 13/01 (20130101) H03M 13/005 (20130101) H03M 13/154 (20130101) H03M 13/1575 (20130101)
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10229839 — Transition metal-bearing capping film for group III-nitride devices

US 10229839	Anderson et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as Represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Travis J. Anderson (Alexandria, Virginia); Boris N. Feygelson (Springfield, Virginia); Andrew D. Koehler (Alexandria, Virginia); Karl D. Hobart (Alexandria, Virginia); Francis J. Kub (Arnold, Maryland); Jordan Greenlee (Vienna, Virginia)
ABSTRACT	An method of annealing by: providing a substrate having a III-nitride, sapphire, silicon, diamond, gallium arsenide, or silicon carbide surface; depositing a layer of a transition metal nitride directly on the surface; and annealing the substrate at at least 900° C. in an oxygen-free environment. An article having: a substrate having a III-nitride, sapphire, silicon, diamond, gallium arsenide, or silicon carbide surface; and a layer of a transition metal nitride directly on the surface.
FILED	Monday, May 01, 2017
APPL NO	15/582785
ART UNIT	2822 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0254 (20130101) H01L 21/2654 (20130101) H01L 21/3245 (20130101) Original (OR) Class H01L 29/2003 (20130101)
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10229897 — Multi-layer semiconductor structure and methods for fabricating multi-layer semiconductor structures

US 10229897	Das
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Rabindra N. Das (Lexington, Massachusetts)
ABSTRACT	A multi-layer semiconductor device (or structure) includes at least two semiconductor structures, each of the at least two semiconductor structures having first and second opposing surfaces. Additionally, each of the at least two semiconductor structures includes a first section having first and second opposing surfaces and a plurality of electrical connections extending between select portions of the first and second surfaces. Each of the at least two semiconductor structures also includes a second section having first and second opposing surfaces, with the first surface of the second section disposed over and coupled to the second surface of the first section. Methods for fabricating a multi-layer semiconductor structure from a plurality of semiconductor structures are also provided.
FILED	Wednesday, September 21, 2016
APPL NO	15/271755
ART UNIT	2897 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/187 (20130101) H01L 21/4846 (20130101) H01L 21/30625 (20130101) H01L 21/76898 (20130101) H01L 23/481 (20130101) H01L 23/528 (20130101) H01L 23/5226 (20130101) H01L 23/5329 (20130101) H01L 23/5383 (20130101) H01L 23/5385 (20130101) H01L 23/5386 (20130101) H01L 23/49822 (20130101) H01L 23/49827 (20130101) H01L 23/49838 (20130101) H01L 23/53209 (20130101) H01L 24/16 (20130101) H01L 25/00 (20130101) H01L 25/50 (20130101) H01L 25/105 (20130101) Original (OR) Class H01L 25/0657 (20130101) H01L 2224/16225 (20130101) H01L 2224/16227 (20130101) H01L 2224/73253 (20130101) H01L 2224/92144 (20130101) H01L 2225/1023 (20130101) H01L 2225/1058 (20130101) H01L 2225/1082 (20130101) H01L 2225/1094 (20130101) H01L 2225/06513 (20130101) H01L 2225/06541 (20130101) H01L 2924/15192 (20130101) H01L 2924/15311 (20130101)
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10230137 — Estimating core temperatures of battery cells in a battery pack

US 10230137	Lin et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Tank-Automotive and Armaments Command (TACOM)
APPLICANT(S)	The Regents of the University of Michigan (Ann Arbor, Michigan); The United States of America, as represented by the Secretary of the Army, Washington, D.C. (Washington, District of Columbia)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan); The United States of America, by Sec. of the Army (Washington, District of Columbia)
INVENTOR(S)	Xinfan Lin (Ypsilanti, Michigan); Yi Ding (Canton, Michigan); Matthew P. Castanier (Ann Arbor, Michigan); Anna G. Stefanopoulou (Ann Arbor, Michigan)
ABSTRACT	A method and a system of estimating core temperatures of battery cells in a battery pack can include several steps. In one step, a surface temperature of one or more battery cell(s) is received, a current of the one or more battery cell(s) is received, an inlet temperature of coolant provided to the battery pack is received, and a flow rate or velocity of the coolant is received. In another step, estimations are made including those of a cell-lumped internal electrical resistance of the battery cell(s), a cell-lumped conduction resistance between a core and a surface of the battery cell(s), and a cell-lumped convection resistance between the surface and the coolant. In yet another step, an estimation is made of a core temperature of the battery cell(s) based upon the received and estimated values of previous steps.
FILED	Thursday, May 23, 2013
APPL NO	14/403057
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/42 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 31/3648 (20130101) G01R 31/3662 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/482 (20130101) H01M 10/486 (20130101) Original (OR) Class H01M 10/633 (20150401) H01M 10/6557 (20150401) Climate Change Mitigation Technologies Related to Transportation Y02T 10/7011 (20130101)
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10230170 — Broadband metal lens antenna

US 10230170	Boulais et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Kevin A. Boulais (La Plata, Maryland); Walter D. Sessions (Marietta, Georgia); Reniery Cevallos (La Plata, Maryland); Sarah C. Weston (King George, Virginia); Lucas R. Hale (King George, Virginia)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy. (Washington, District of Columbia)
INVENTOR(S)	Kevin A. Boulais (La Plata, Maryland); Walter D. Sessions (Marietta, Georgia); Reniery Cevallos (La Plata, Maryland); Sarah C. Weston (King George, Virginia); Lucas R. Hale (King George, Virginia)
ABSTRACT	A metal lens is provided for length compacting a horn antenna across a frequency bandwidth. The metal lens includes a feed guide segment having an input cross-section, an intermediate segment, and an exit segment. The feed guide segment receives a signal from the horn antenna along a carry direction; an intermediate segment that expands from the input cross-section laterally to the carry direction. The intermediate segment incorporates an intermediate split vane perpendicular to the carry direction to divide the signal along the carry direction. The exit segment incorporates a plurality of terminating split vanes lateral to the carry direction for transmitting the output signals.
FILED	Monday, July 10, 2017
APPL NO	15/644856
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 13/02 (20130101) H01Q 19/08 (20130101) Original (OR) Class
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10230241 — Self-optimizing hybrid power system

US 10230241	Rule et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Evan T. Rule (Burtonsville, Maryland); Eric B. Shields (Germantown, Maryland); Crystal P. Lutkenhouse (Garrett Park, Maryland); John A. Trehubenko (Arlington, Virginia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Evan T. Rule (Burtonsville, Maryland); Eric B. Shields (Germantown, Maryland); Crystal P. Lutkenhouse (Garrett Park, Maryland); John A. Trehubenko (Arlington, Virginia)
ABSTRACT	An exemplary embodiment of the present invention's self-optimizing hybrid power system includes a generator, a solar array, batteries, a GPS, a thermometer, a pyranometer, a power manager, and a computer. The computer: (i) establishes maximum and minimum state-of-charge set points; (ii) receives measurement data from the generator (load), the GPS (location), the thermometer (temperature), and the solar irradiance sensor (solar irradiance); (iii) accesses a historic database that relates to generator load, location, temperature, and solar irradiance; (iv) based on the historic database, predicts a solar profile and a generator load profile; (v) calculates an optimized maximum state-of-charge set point and an optimized minimum state-of-charge set point, based on the predicted solar profile, the predicted generator load profile, the measured location, the measured temperature, and the measured solar irradiance; (vi) transmits control signals to the power manager to vary the maximum and/or minimum state-of-charge set point.
FILED	Friday, September 30, 2016
APPL NO	15/282517
ART UNIT	2116 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/0205 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/383 (20130101) Original (OR) Class H02J 13/00 (20130101)
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10230389 — Superconductor analog to digital converter

US 10230389	Inamdar et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Hypres, Inc. (Elmsford, New York)
ASSIGNEE(S)	Hypres, Inc. (Elmsford, New York)
INVENTOR(S)	Amol Inamdar (Elmsford, New York); Deepnarayan Gupta (Briarcliff Manor, New York)
ABSTRACT	Superconductor analog-to-digital converters (ADC) offer high sensitivity and large dynamic range. One approach to increasing the dynamic range further is with a subranging architecture, whereby the output of a coarse ADC is converted back to analog and subtracted from the input signal, and the residue signal fed to a fine ADC for generation of additional significant bits. This also requires a high-gain broadband linear amplifier, which is not generally available within superconductor technology. In a preferred embodiment, a distributed digital fluxon amplifier is presented, which also integrates the functions of integration, filtering, and flux subtraction. A subranging ADC design provides two ADCs connected with the fluxon amplifier and subtractor circuitry that would provide a dynamic range extension by about 30-35 dB.
FILED	Thursday, August 17, 2017
APPL NO	15/679829
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Coding; Decoding; Code Conversion in General H03M 1/0854 (20130101) H03M 1/1245 (20130101) H03M 3/458 (20130101) Original (OR) Class
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10231359 — Active control for two-phase cooling

US 10231359	Chainer et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Timothy J. Chainer (Putnam Valley, New York); Pritish R. Parida (Stamford, Connecticut); Joel A. Silberman (Somers, New York)
ABSTRACT	Methods and devices for active control for two-phase cooling include a cooling volume that has cavities and active coolant flow controls in the cavities configured to adjust coolant flow through the cavities. A reservoir in fluid communication with the cavities and there is a two-phase coolant in the reservoir and cavities. The two-phase coolant has a phase transition temperature between an ambient temperature and an expected device temperature. A coolant sensor is configured to determine a coolant phase condition in the cavities. A control module is configured to adjust the active coolant flow controls in response to the determined coolant phase condition.
FILED	Tuesday, June 23, 2015
APPL NO	14/748074
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/06 (20130101) F28D 15/025 (20130101) F28D 15/0266 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20327 (20130101) H05K 7/20336 (20130101) H05K 7/20381 (20130101) Original (OR) Class H05K 7/20809 (20130101) H05K 7/20827 (20130101) H05K 7/20836 (20130101)
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Department of Energy (DOE)

10226731 — Xenon collection method and system

US 10226731	Hayes et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	James C. Hayes (Richland, Washington); Paul H. Humble (Richland, Washington); Mark E. Panisko (Richland, Washington); Warren W. Harper (Richland, Washington); Timothy L. Stewart (Pendleton, Oregon)
ABSTRACT	A method and system for collecting xenon (Xe) is described. A microchannel heat exchanger is used in combination with a mechanical cooler and an absorbent. A combination of components makes up a Xe Collection Subsystem that is adapted for use in an efficient process for collecting, purifying, and measuring Xe isotopes collected from air as part of the International Monitoring System.
FILED	Tuesday, June 19, 2018
APPL NO	16/012754
ART UNIT	1776 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 46/0036 (20130101) B01D 53/00 (20130101) B01D 53/047 (20130101) B01D 53/261 (20130101) B01D 53/0438 (20130101) Original (OR) Class B01D 2253/102 (20130101) B01D 2253/104 (20130101) B01D 2256/18 (20130101) B01D 2257/11 (20130101) B01D 2257/80 (20130101) B01D 2257/102 (20130101) B01D 2257/104 (20130101) B01D 2259/416 (20130101) B01D 2259/4145 (20130101) Non-metallic Elements; Compounds Thereof; C01B 23/0052 (20130101) C01B 23/0057 (20130101) C01B 23/0063 (20130101) C01B 2210/0015 (20130101) C01B 2210/0017 (20130101) C01B 2210/0037 (20130101) C01B 2210/0048 (20130101) C01B 2210/0051 (20130101) C01B 2210/0062 (20130101)
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10227287 — Method for detecting and determining levels of monolignol ester conjugates incorporated into lignin and compounds relating thereto

US 10227287	Ralph et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	John Ralph (Madison, Wisconsin); Steven D Karlen (Verona, Wisconsin); Fachuang Lu (Madison, Wisconsin); Dharshana Padmakshan (Madison, Wisconsin)
ABSTRACT	Described is a method of detecting and/or determining levels of incorporation of monolignol ferulate conjugate esters into lignin by derivatizing the lignin, reductively cleaving the lignin, labeling the cleavage products, and then detecting cleavage products derived from monolignol ester conjugates via differential attachment of the label.
FILED	Thursday, December 31, 2015
APPL NO	14/985720
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 69/007 (20130101) C07C 69/16 (20130101) C07C 69/73 (20130101) Original (OR) Class C07C 69/84 (20130101) C07C 69/86 (20130101) C07C 69/92 (20130101) C07C 69/732 (20130101) C07C 69/734 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101) G01N 2400/26 (20130101) G01N 2458/15 (20130101) G01N 2560/00 (20130101)
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10227573 — Dominant negative mutations of Arabidopsis RWA

US 10227573	Scheller et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Henrik Vibe Scheller (Millbrae, California); Dominique Loque (Albany, California); Soe Myat Htwe (Daly City, California)
ABSTRACT	The present invention provides for dominant negative mutations of Arabidopsis REDUCING WALL ACETYLATION (RWA).
FILED	Friday, March 14, 2014
APPL NO	14/213761
ART UNIT	1662 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1029 (20130101) Original (OR) Class C12N 15/8261 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101)
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10227601 — PtDUF266 gene regulating cell wall biosynthesis and recalcitrance in populus

US 10227601	Chen et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Jin-Gui Chen (Oak Ridge, Tennessee); Sara Jawdy (Oak Ridge, Tennessee); Xiaohan Yang (Knoxville, Tennessee); Gerald A. Tuskan (Oak Ridge, Tennessee); Yongil Yang (Oak Ridge, Tennessee); Lee E. Gunter (Oak Ridge, Tennessee)
ABSTRACT	This disclosure provides genetically modified plants having desirable levels of sugar release, cellulose content and reduction of recalcitrance; methods of genetically modifying plants to modulate sugar release, cellulose and lignin contents; and uses of such plants. The inventors have determined that genetic modification of PdDUF266A from Populus, encoded by locus Potri.011G009500 resulted in transgenic Populus trees with changes in lignin and cellulose content as well as altered sugar release phenotypes. Plants with altered sugar release, cellulose and lignin content, based on modulation of the expression or activity of the PdDUF266A gene, have diverse uses including pulp and paper production, and biofuel and bioproducts production.
FILED	Monday, August 28, 2017
APPL NO	15/687818
ART UNIT	1663 — Plants
CURRENT CPC	Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8213 (20130101) C12N 15/8217 (20130101) C12N 15/8218 (20130101) C12N 15/8245 (20130101) Original (OR) Class C12N 15/8246 (20130101) C12N 15/8255 (20130101) C12N 15/8261 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/06 (20130101) C12P 7/10 (20130101) C12P 2203/00 (20130101)
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10227614 — Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same

US 10227614	Morant
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	NOVOZYMES A/S (Bagsvaerd, Denmark); NOVOZYMES, INC. (Davis, California)
ASSIGNEE(S)	NOVOZYMES A/S (Bagsvaerd, Denmark); NOVOZYMES, INC. (Davis, California)
INVENTOR(S)	Marc Morant (Copenhagen, Denmark)
ABSTRACT	The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
FILED	Friday, January 06, 2017
APPL NO	15/400361
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2437 (20130101) C12N 9/2445 (20130101) C12N 9/2482 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) C12P 7/14 (20130101) Original (OR) Class C12P 7/16 (20130101) C12P 7/20 (20130101) C12P 19/02 (20130101) C12P 19/14 (20130101) C12P 2203/00 (20130101) Enzymes C12Y 302/01008 (20130101) C12Y 302/01021 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/16 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/52 (20151101)
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10227617 — Sequestration of carbon dioxide with hydrogen to useful products

US 10227617	Adams et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia); NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
ASSIGNEE(S)	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia); NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
INVENTOR(S)	Michael W. W. Adams (Athens, Georgia); Robert M. Kelly (Cary, North Carolina); Aaron B. Hawkins (Raleigh, North Carolina); Angeli Lal Menon (Athens, Georgia); Gina Lynette Pries Lipscomb (Athens, Georgia); Gerrit Jan Schut (Athens, Georgia)
ABSTRACT	Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.
FILED	Thursday, January 19, 2017
APPL NO	15/410205
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/0067 (20130101) C12N 9/88 (20130101) C12N 9/90 (20130101) C12N 9/93 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class Enzymes C12Y 101/01 (20130101) C12Y 103/01095 (20150701) C12Y 402/01116 (20130101) C12Y 501/99001 (20130101) C12Y 504/99002 (20130101) C12Y 602/01036 (20130101)
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10227622 — Host cell modified to produce 2-pyrrolidone

US 10227622	Zhang et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Jingwei Zhang (Fullerton, California); Jay D. Keasling (Berkeley, California)
ABSTRACT	The present invention provides for a genetically modified host cell comprising a 2-pyrrolidone synthase, or an enzymatically active fragment thereof, heterologous to the host cell.
FILED	Thursday, April 14, 2016
APPL NO	15/099488
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 9/93 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/10 (20130101) Original (OR) Class Enzymes C12Y 401/01015 (20130101)
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10227630 — Antimicrobial agents from microbial genomes

US 10227630	Sorek et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Rotem Sorek (Rehovot, Israel); Edward M. Rubin (Berkeley, California)
ABSTRACT	We describe a method for mining microbial genomes to discover antimicrobial genes and proteins having broad spectrum of activity. Also described are antimicrobial genes and their expression products from various microbial genomes that were found using this method. The products of such genes can be used as antimicrobial agents or as tools for molecular biology.
FILED	Thursday, August 01, 2013
APPL NO	13/957249
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/02 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/164 (20130101) Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8281 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Original (OR) Class C12Q 1/6895 (20130101) C12Q 2600/142 (20130101) C12Q 2600/158 (20130101)
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10228140 — Gas-only cartridge for a premix fuel nozzle

US 10228140	Cihlar et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	David William Cihlar (Greenville, South Carolina); Patrick Benedict Melton (Horse Shoe, North Carolina); William David York (Greer, South Carolina)
ABSTRACT	A gas-only cartridge for a fuel nozzle includes a flange that defines a plurality of apertures for receiving a gaseous fuel, an outer tube that is coupled to the flange and an inner tube that extends axially within the outer tube. The inner tube and the outer tube define a fuel passage therebetween and the fuel passage is in fluid communication with the plurality of apertures of the flange. A fuel distribution tip is disposed at a downstream end of the gas-only cartridge and defines a plurality of fuel ports circumferentially spaced along and annularly arranged about an outer surface of the fuel distribution tip. The fuel ports are in fluid communication with the fuel passage.
FILED	Thursday, February 18, 2016
APPL NO	15/046482
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Burners F23D 14/02 (20130101) F23D 14/58 (20130101) F23D 17/002 (20130101) F23D 2204/10 (20130101) F23D 2900/00016 (20130101) F23D 2900/14021 (20130101) F23D 2900/14701 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/14 (20130101) F23R 3/28 (20130101) Original (OR) Class F23R 3/30 (20130101) F23R 3/32 (20130101) F23R 3/36 (20130101) F23R 3/46 (20130101) F23R 3/286 (20130101)
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10228290 — Systems and methods for wireless temperature sensing

US 10228290	Lin et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Yirong Lin (El Paso, Texas); Norman D. Love (El Paso, Texas)
ABSTRACT	Wireless temperature sensing systems and methods include an active sensor for determining temperature parameters in harsh environments, such as in very high temperature conditions, and wireless conveyance of the detected parameters. In an example embodiment, a pyroelectric element can generate a voltage when subjected to a temperature change. A coil is electrically coupled to the pyroelectric element and configured to generate a magnetic field in response to a current induced by the voltage generated by the pyroelectric element. A pickup is electromagnetically coupled with and detects the magnetic field generated by the coil, and the pickup is configured to provide an output corresponding to the detected magnetic field.
FILED	Wednesday, April 12, 2017
APPL NO	15/485494
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/025 (20130101) G01J 5/34 (20130101) Original (OR) Class
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10228343 — Electrochemical detection of carbon dioxide using a carbohydrate based coordination polymer

US 10228343	Stoddart et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois); KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (KACST) (Riyadh, Saudi Arabia)
ASSIGNEE(S)	Northwestern University (Evanston, Iowa); King Abdulaziz City for Science and Technology (KACST) (Riyadh, Saudi Arabia)
INVENTOR(S)	James Fraser Stoddart (Evanston, Illinois); Jeremiah J. Gassensmith (Allen, Texas); Nak Cheon Jeong (Daegu, South Korea); Omar K. Farha (Glenview, Illinois)
ABSTRACT	An electrochemical sensor for an analyte is provided. The electrochemical sensor includes CDMOF-2. The CDMOF-2 is capable of binding reversibly to CO₂as an analyte, thereby quantitatively detecting the analyte in a mixture. The CDMOF-2 is formed from reaction of γ-cyclodextrin with RbOH in the presence of methanol.
FILED	Thursday, September 03, 2015
APPL NO	14/844949
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4073 (20130101) G01N 27/4074 (20130101) Original (OR) Class
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10228345 — High temperature sensor for reducing gas

US 10228345	Lei et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S)	University of Connecticut (Farmington, Connecticut)
INVENTOR(S)	Yu Lei (Mansfield Center, Connecticut); Yixin Liu (Willimantic, Connecticut)
ABSTRACT	The present disclosure provides improved sensor assemblies for gases. More particularly, the present disclosure provides for gas sensor assemblies operating at high temperature. Improved high temperature sensor assemblies for reducing gas are provided. In some embodiments, the present disclosure provides advantageous impedancemetric high temperature gas sensor assemblies based on electrospun nanofibers and having selectivity towards reducing gas, and related methods of use. In exemplary embodiments, the present disclosure provides for impedancemetric high temperature gas sensor assemblies having selectivity towards reducing gas. In certain embodiments, the sensor assembly includes electrospun nanofibers. Impedancemetric techniques have been employed at high operating frequency (e.g., 10⁵Hz) for the first time to provide real-time assemblies, methods and devices to sensitively and/or selectively detect reducing gas (e.g., CO, C₃H₈(propane), etc.) at high temperatures (e.g., at about 800° C.).
FILED	Friday, July 11, 2014
APPL NO	14/903497
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/026 (20130101) G01N 27/304 (20130101) G01N 27/4166 (20130101) Original (OR) Class G01N 33/004 (20130101) G01N 33/0037 (20130101) G01N 33/0042 (20130101) Technologies for Adaptation to Climate Change Y02A 50/245 (20180101)
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10228490 — Hub and spoke system for detecting and locating gas leaks

US 10228490	Rieker et al.
FUNDED BY	Department of Commerce (DOC) Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado); The United States of America as represented by the Secretary of Commerce (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, As Represented by the Secretary of Commerce (Washington, District of Columbia); The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
INVENTOR(S)	Gregory B Rieker (Boulder, Colorado); Ian Coddington (Boulder, Colorado); Nathan R Newbury (Boulder, Colorado); Kuldeep Prasad (Vienna, Virginia); Anna Karion (Bethesda, Maryland)
ABSTRACT	A system for detecting gas leaks and determining their location and size. A data gathering portion of the system utilizes a hub and spoke configuration to collect path-integrated spectroscopic data over multiple open paths around an area. A processing portion of the system applies a high resolution transport model together with meteorological data of the area to generate an influence function of possible leak locations on gas detector measurement paths, and applies an inversion model to the influence function and the spectroscopic data to generate gas source size and location.
FILED	Wednesday, May 11, 2016
APPL NO	15/152543
ART UNIT	2857 — Printing/Measuring and Testing
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/42 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/202 (20130101) Meteorology G01W 1/00 (20130101) Original (OR) Class
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10228665 — Emulator for rotary energy sources

US 10228665	Neely et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Jason C. Neely (Albuquerque, New Mexico); Steven F. Glover (Albuquerque, New Mexico); Forest Eugene White (Albuquerque, New Mexico); Jason Ryan Finn (Albuquerque, New Mexico)
ABSTRACT	An emulator is described herein, wherein the emulator is configured to emulate a rotary energy generator. The rotary energy generator can be one of a wind turbine, a diesel engine, or a hydrokinetic generator. The emulator includes an electromechanical motor that is mechanically linked to a generator. A motor drive is electrically coupled to the electromechanical motor, and controls torque at a rotor of the electromechanical motor. Electromagnetic torque produced by the generator is estimated, and the motor drive is controlled based upon the estimated generator torque.
FILED	Friday, February 07, 2014
APPL NO	14/175395
ART UNIT	2194 — Interprocess Communication and Software Development
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/04 (20130101) Original (OR) Class
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10229756 — In space startup method for nuclear fusion rocket engines

US 10229756	Paluszek et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Princeton Plasma Physics Laboratory (PPPL) Federally Funded Research and Development Center (FFRDC) Operated by Princeton University (PRINCETON) at Princeton, NJ
APPLICANT(S)	Princeton Satellite Systems, Inc. (Plainsboro, New Jersey); The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S)	PRINCETON SATELLITE SYSTEMS, INC. (Plainsboro, New Jersey); THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
INVENTOR(S)	Michael A. Paluszek (Princeton, New Jersey); Eric M. Ham (Princeton, New Jersey); Yosef Razin (Princeton, New Jersey); Samuel A. Cohen (Princeton, New Jersey)
ABSTRACT	The invention is for a startup system for nuclear fusion engines in space. The combustion of hydrogen and oxygen produces heat that is used by a heat engine to produce electricity. This can be supplemented by electricity from other operating engines. The exhaust from the combustion is condensed and electrolyzed to produce hydrogen and oxygen once the engine is in operation. This provides a constant source of energy for future startups. The engine is started up at partial power in electricity generation mode and this power replaces the power from the combustion as it grows. The combustor uses the same heat engine as the nuclear engine uses for power generation.
FILED	Friday, August 22, 2014
APPL NO	14/466425
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Internal-combustion Piston Engines; Combustion Engines in General F02B 2043/106 (20130101) Fusion Reactors G21B 1/00 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/10 (20130101)
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10229760 — CRDM with separate scram latch engagement and locking

US 10229760	Dodd et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE)
APPLICANT(S)	BWXT mPower, Inc. (Charlotte, North Carolina); BWXT Nuclear Operations Group, Inc. (Lynchburg, Virginia)
ASSIGNEE(S)	BWXT mPower, Inc. (Charlotte, North Carolina)
INVENTOR(S)	Christopher D. Dodd (Lakewood, Ohio); Paul K. DeSantis (Bentleyville, Ohio); Kevin J. Stambaugh (Willowick, Ohio); Allan R. Mackovjak (Willoughby, Ohio); John P. McLaughlin (North Royalton, Ohio); Brett T. Goodyear (Twinsburg, Ohio); Michael J. Edwards (Forest, Virginia); Matthew W. Ales (Forest, Virginia)
ABSTRACT	A control rod drive mechanism (CRDM) configured to latch onto the lifting rod of a control rod assembly and including separate latch engagement and latch holding mechanisms. A CRDM configured to latch onto the lifting rod of a control rod assembly and including a four-bar linkage closing the latch, wherein the four-bar linkage biases the latch closed under force of gravity.
FILED	Thursday, February 06, 2014
APPL NO	14/174638
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Nuclear Reactors G21C 7/14 (20130101) Original (OR) Class G21C 9/02 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/39 (20130101)
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10229776 — Multi-phase magnetic component and method of forming

US 10229776	Johnson et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Francis Johnson (Clifton Park, New York); Min Zou (Niskayuna, New York); Patel Bhageerath Reddy (Niskayuna, New York); James Pellegrino Alexander (Ballston Lake, New York); Ayman Mohamed Fawzi EL-Refaie (Niskayuna, New York)
ABSTRACT	A magnetic component including first and second regions, and a method of varying the magnetization values in different regions of the magnetic component are disclosed. The first and the second regions are characterized by a nitrogen content that is different from each other. At least one of the first region and the second region is partially-magnetic and has a nitrogen content in a range from about 0.1 weight % to about 0.4 weight % of that region. A concentration of carbon, if present, of both the first and second regions is less than about 0.05 weight % of the respective regions.
FILED	Wednesday, March 23, 2016
APPL NO	15/078439
ART UNIT	2834 — Electrical Circuits and Systems
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 7/14 (20130101) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 1/26 (20130101) C21D 8/1255 (20130101) C21D 8/1277 (20130101) C21D 2221/00 (20130101) Alloys C22C 38/04 (20130101) C22C 38/30 (20130101) C22C 38/38 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 8/04 (20130101) C23C 8/26 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/147 (20130101) H01F 7/021 (20130101) Original (OR) Class H01F 41/0253 (20130101) Dynamo-electric Machines H02K 1/02 (20130101) H02K 1/246 (20130101) H02K 19/02 (20130101)
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10229777 — Graded magnetic component and method of forming

US 10229777	Zou et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Min Zou (Niskayuna, New York); Francis Johnson (Clifton Park, New York); Patel Bhageerath Reddy (Niskayuna, New York); James Pellegrino Alexander (Ballston Lake, New York); Ayman Mohamed Fawzi EL-Refaie (Niskayuna, New York); Wanming Zhang (Niskayuna, New York)
ABSTRACT	A magnetic component including at least one region is disclosed. The at least one region includes nitrogen and a concentration of the nitrogen in the at least one region is graded across a dimension of the at least one region. Further, a saturation magnetization in the at least one region is graded across the dimension of the at least one region. Further, a method of varying the magnetization values in at least one region of the magnetic component is disclosed.
FILED	Wednesday, March 23, 2016
APPL NO	15/078516
ART UNIT	2834 — Electrical Circuits and Systems
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 7/14 (20130101) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 1/26 (20130101) C21D 2221/00 (20130101) Alloys C22C 38/04 (20130101) C22C 38/30 (20130101) C22C 38/38 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 8/04 (20130101) C23C 8/26 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/147 (20130101) H01F 7/021 (20130101) Original (OR) Class H01F 41/0253 (20130101) Dynamo-electric Machines H02K 1/02 (20130101) H02K 1/246 (20130101) H02K 19/02 (20130101)
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10229958 — Devices combining thin film inorganic LEDs with organic LEDs and fabrication thereof

US 10229958	Forrest et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Basic Energy Sciences (BES) Energy Frontier Research Centers (EFRC)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Stephen R. Forrest (Ann Arbor, Michigan); Kyusang Lee (Ann Arbor, Michigan)
ABSTRACT	Devices including organic and inorganic LEDs are provided. Techniques for fabricating the devices include fabricating an inorganic LED on a parent substrate and transferring the LED to a host substrate via a non-destructive ELO process. Scaling techniques are also provided, in which an elastomeric substrate is deformed to achieve a desired display size.
FILED	Monday, August 27, 2018
APPL NO	16/112960
ART UNIT	2892 — Semiconductors/Memory
CURRENT CPC	Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/32 (20130101) G09G 3/3208 (20130101) G09G 2300/0452 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/322 (20130101) H01L 27/3209 (20130101) H01L 27/3211 (20130101) H01L 27/3216 (20130101) H01L 27/3225 (20130101) Original (OR) Class H01L 33/0079 (20130101) H01L 51/0001 (20130101) H01L 51/56 (20130101) H01L 51/0097 (20130101) H01L 2227/326 (20130101)
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10230014 — Hybrid vapor phase-solution phase growth techniques for improved CZT(S,Se) photovoltaic device performance

US 10230014	Chang et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Liang-Yi Chang (White Plains, New York); Talia S. Gershon (White Plains, New York); Richard A. Haight (Mahopac, New York); Yun Seog Lee (White Plains, New York)
ABSTRACT	A hybrid vapor phase-solution phase CZT(S,Se) growth technique is provided. In one aspect, a method of forming a kesterite absorber material on a substrate includes the steps of: depositing a layer of a first kesterite material on the substrate using a vapor phase deposition process, wherein the first kesterite material includes Cu, Zn, Sn, and at least one of S and Se; annealing the first kesterite material to crystallize the first kesterite material; and depositing a layer of a second kesterite material on a side of the first kesterite material opposite the substrate using a solution phase deposition process, wherein the second kesterite material includes Cu, Zn, Sn, and at least one of S and Se, wherein the first kesterite material and the second kesterite material form a multi-layer stack of the absorber material on the substrate. A photovoltaic device and method of formation thereof are also provided.
FILED	Thursday, November 03, 2016
APPL NO	15/342618
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0256 (20130101) H01L 21/02422 (20130101) H01L 21/02474 (20130101) H01L 21/02477 (20130101) H01L 21/02485 (20130101) H01L 21/02505 (20130101) H01L 21/02557 (20130101) H01L 21/02568 (20130101) H01L 21/02628 (20130101) H01L 21/02631 (20130101) H01L 31/065 (20130101) Original (OR) Class H01L 31/072 (20130101) H01L 31/0326 (20130101) H01L 31/0392 (20130101) H01L 31/0749 (20130101) H01L 31/1864 (20130101) H01L 31/1884 (20130101) H01L 31/02168 (20130101) H01L 31/022466 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101)
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10230124 — Gravity induced flow cell

US 10230124	Hopkins et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Brandon James Hopkins (Cambridge, Massachusetts); Alexander H. Slocum (Bow, New Hampshire); Xinwei Chen (Cambridge, Massachusetts); Yet-Ming Chiang (Weston, Massachusetts); Frank Yongzhen Fan (Cambridge, Massachusetts); Ahmed Helal (Cambridge, Massachusetts); Zheng Li (Arlington, Massachusetts); Kyle C. Smith (Champaign, Illinois); W. Craig Carter (Jamaica Plain, Massachusetts)
ABSTRACT	The flow cell includes first and second reservoirs having a selected volume containing a flowable redox electrode. A membrane separates charged and discharged material. An energy-extraction region includes electronically conductive porous current collectors through or adjacent to which the flowable redox electrodes flow and to which charge transfer occurs. Structure is provided for altering orientation of the flow cell whereby gravity induces flow of the flowable redox electrode between the first and second reservoirs to deliver power. By varying the angle of the cell, flow rate and power delivered on discharge or the charge rate on charge may be varied.
FILED	Tuesday, December 02, 2014
APPL NO	14/557924
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/20 (20130101) H01M 8/188 (20130101) Original (OR) Class H01M 8/04276 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/528 (20130101)
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10230125 — Method and system to maintain electrolyte stability for all-iron redox flow batteries

US 10230125	Evans et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	ESS TECH, INC. (Portland, Oregon)
ASSIGNEE(S)	ESS Tech, Inc. (Wilsonville, Oregon)
INVENTOR(S)	Craig E. Evans (West Linn, Oregon); Yang Song (West Linn, Oregon)
ABSTRACT	Methods and systems are provided which maintain the positive and negative electrolyte pH and stability of a redox flow battery through the use of electrochemical rebalancing cells. The electrochemical cells may be activated by applying an electrical load to affect changes to the pH of the electrolytes. The use of the electrochemical cells improves long term performance stability redox flow batteries by decreasing and/or eliminating Fe(OH)₃precipitation formation.
FILED	Wednesday, December 31, 2014
APPL NO	14/588225
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/184 (20130101) H01M 8/188 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/528 (20130101)
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10230169 — Meta-antenna

US 10230169	Daniel
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E) System of Printed Hybrid Intelligent Nano-Chemical Sensors (SPHINCS)
APPLICANT(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S)	PALO ALTO RESEARCH CENTER INCORPORATED (Palo Alto, California)
INVENTOR(S)	George W. Daniel (Mountain View, California)
ABSTRACT	A small, inexpensive, printable meta-antenna system is described. In addition to being smaller than existing antennas, the meta-antenna improves over them by being omni-directional, and having a broader gain function and better efficiency. Some embodiments include a main element with a shape of a loop and two parasitic elements enclosed by the main element. Each parasitic element may be shaped as a loop with an opening. The openings of the two parasitic elements may be positioned adjacent to opposing sides of the main element, respectively.
FILED	Friday, August 04, 2017
APPL NO	15/669725
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 7/00 (20130101) H01Q 9/0407 (20130101) H01Q 19/005 (20130101) Original (OR) Class
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10230325 — Remote array mapping

US 10230325	Chapman et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Enphase Energy, Inc. (Petaluma, California)
ASSIGNEE(S)	Enphase Energy, Inc. (Petaluma, California)
INVENTOR(S)	Patrick L Chapman (Austin, Texas); Fernando Rodriguez (Austin, Texas); Philip Rothblum (Austin, Texas); Anant K Singh (Richardson, Texas)
ABSTRACT	Electrical component location is provided. Employed location techniques may include providing a cycling signal, having components to be located sense the cycling signal at the same time, report back the sensed signal, and determining relative locations for one or more of the components using the sensed signals reported by the components.
FILED	Friday, October 14, 2016
APPL NO	15/294098
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 50/00 (20130101) Original (OR) Class
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10230643 — Full flow retrieval optimized packet capture

US 10230643	Ferrell
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Paul Ferrell (Los Alamos, New Mexico)
ABSTRACT	A packet capture system may copy packets from an interface to a bucket. When the bucket is full of packets, a new bucket for incoming packets may be started, and the full bucket may be indexed. During the indexing, each packet may be sorted in the bucket by flow, and each flow may be indexed. Once indexing is complete, the packets are written to a flow ordered FCAP file and the indexes are written to disk. The flow ordered nature of the FCAP file combined with the indices and their associated search algorithms allow for rapid retrieval of captured flows.
FILED	Wednesday, April 27, 2016
APPL NO	15/139484
ART UNIT	2464 — Multiplex and VoIP
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 47/21 (20130101) Original (OR) Class H04L 49/9084 (20130101)
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10231356 — Cold plate

US 10231356	Marroquin et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Christopher M. Marroquin (Rochester, Minnesota); Kevin M. O'Connell (Rochester, Minnesota); Mark D. Schultz (Ossining, New York); Shurong Tian (Mount Kisco, New York)
ABSTRACT	A cold plate, an electronic assembly including a cold plate, and a method for forming a cold plate are provided. The cold plate includes an interface plate and an opposing plate that form a plenum. The cold plate includes a plurality of active areas arranged for alignment over respective heat generating portions of an electronic assembly, and non-active areas between the active areas. A cooling fluid flows through the plenum. The plenum, at the non-active areas, has a reduced width and/or reduced height relative to the plenum at the active areas. The reduced width and/or height of the plenum, and exterior dimensions of cold plate, at the non-active areas allow the non-active areas to flex to accommodate surface variations of the electronics assembly. The reduced width and/or height non-active areas can be specifically shaped to fit between physical features of the electronics assembly.
FILED	Monday, November 06, 2017
APPL NO	15/803945
ART UNIT	2835 — Electrical Circuits and Systems
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101) H01L 23/473 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/2049 (20130101) H05K 7/20254 (20130101) Original (OR) Class H05K 7/20509 (20130101)
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National Science Foundation (NSF)

10226194 — Statistical, noninvasive measurement of a patient's physiological state

US 10226194	Grudic et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)	Flashback Technologies, Inc. (Louisville, Colorado)
INVENTOR(S)	Gregory Zlatko Grudic (Niwot, Colorado); Steven Lee Moulton (Littleton, Colorado); Isobel Jane Mulligan (Niwot, Colorado)
ABSTRACT	Tools and techniques for the rapid, continuous, invasive and/or noninvasive measurement, estimation, and/or prediction of a patient's physiological state. In an aspect, some tools and techniques can estimate predict the onset of conditions intracranial pressure, an amount of blood volume loss, cardiovascular collapse, and/or dehydration. Some tools can recommend (and, in some cases, administer) a therapeutic treatment for the patient's condition. In another aspect, some techniques employ high speed software technology that enables active, long term learning from extremely large, continually changing datasets. In some cases, this technology utilizes feature extraction, state-of-the-art machine learning and/or statistical methods to autonomously build and apply relevant models in real-time.
FILED	Monday, September 28, 2015
APPL NO	14/867938
ART UNIT	3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/021 (20130101) A61B 5/031 (20130101) Original (OR) Class A61B 5/0205 (20130101) A61B 5/0402 (20130101) A61B 5/742 (20130101) A61B 5/0836 (20130101) A61B 5/02108 (20130101) A61B 5/02405 (20130101) A61B 5/02416 (20130101) A61B 5/4261 (20130101) A61B 5/4839 (20130101) A61B 5/14542 (20130101) A61B 5/14551 (20130101) A61B 8/488 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) G06F 19/3481 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101) G16H 50/50 (20180101)
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10226768 — Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting

US 10226768	Chiou et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Aeronautics and Space Administration (NASA) National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Pei-Yu E. Chiou (Los Angeles, California); Ting-Hsiang S. Wu (Culver City, California); Michael A. Teitell (Tarzana, California)
ABSTRACT	In certain embodiments this invention provides a pulsed-laser triggered microfluidic switching mechanism that can achieve a switching time of 70 μs. This switching speed is two orders of magnitude shorter than that of the fastest switching mechanism utilized in previous μFACS.
FILED	Friday, April 08, 2016
APPL NO	15/094919
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0636 (20130101) B01L 2200/0652 (20130101) B01L 2300/123 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2400/0442 (20130101) B01L 2400/0454 (20130101) B01L 2400/0622 (20130101) B01L 2400/0655 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0001 (20130101) F16K 99/004 (20130101) F16K 99/0026 (20130101) F16K 99/0028 (20130101) F16K 99/0061 (20130101) F16K 2099/0084 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1459 (20130101) G01N 2015/149 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0391 (20150401) Y10T 137/2224 (20150401)
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10227566 — Three dimensional matrix for cancer stem cells

US 10227566	Jabbari
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	University of South Carolina (Columbia, South Carolina)
ASSIGNEE(S)	University of South Carolina (Columbia, South Carolina)
INVENTOR(S)	Esmaiel Jabbari (Columbia, South Carolina)
ABSTRACT	Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.
FILED	Wednesday, October 29, 2014
APPL NO	14/527028
ART UNIT	1675 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0695 (20130101) Original (OR) Class C12N 2533/30 (20130101) C12N 2537/10 (20130101)
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10227804 — Deployable joint

US 10227804	Howell et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Engineering (ENG) Office of Emerging Frontiers in Research and Innovation (EFRI)
APPLICANT(S)	BRIGHAM YOUNG UNIVERSITY (Provo, Utah)
ASSIGNEE(S)	Brigham Young University (Provo, Utah)
INVENTOR(S)	Larry L. Howell (Orem, Utah); Todd Nelson (Provo, Utah)
ABSTRACT	According to an aspect, a device may include a deployable rolling joint having a first deployable joint member, a second deployable joint member, and a plurality of flexures coupled to the first deployable joint member and the second deployable joint member. The deployable rolling joint may move from an undeployed state to a deployed state in which the first deployable joint member forms a convex surface portion and the second deployable joint member forms a convex surface portion. When the deployable rolling joint is in the deployed state, the convex surface portion of the first deployable joint member may roll with respect the convex surface portion of the second deployable joint member, and the plurality of flexures may hold the first deployable joint member and the second deployable joint member together as the first deployable joint member and the second deployable joint member roll across each other.
FILED	Tuesday, December 15, 2015
APPL NO	14/969979
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/30 (20130101) A61F 2002/30092 (20130101) Hinges or Suspension Devices for Doors, Windows or Wings E05D 1/00 (20130101) E05D 1/04 (20130101) Original (OR) Class Indexing Scheme Relating to Hinges or Other Suspension Devices for Doors, Windows or Wings and Devices for Moving Wings into Open or Closed Position, Checks for Wings and Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing E05Y 2800/00 (20130101) E05Y 2900/60 (20130101) E05Y 2900/502 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 11/04 (20130101)
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10228355 — Volatile eluent preparation

US 10228355	Dasgupta et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Purnendu K. Dasgupta (Arlington, Texas); Charles Phillip Shelor (Arlington, Texas)
ABSTRACT	There is provided a system for performing a chromatographic separation of an analyte, methods of using the system to separate at least one component of an analyte and an eluent generator of use in the system. An exemplary system comprises: (a) an eluent generator comprising: (i) a housing configured to be pressurizable by gas, comprising an annular void defined by the housing, and a gas inlet for the gas and a gas outlet for the gas in fluid communication with the annular void; (ii) a membrane permeable to the gas defining an eluent flow channel disposed within the annular void, the eluent flow channel having an eluent precursor fluid inlet and an eluent outlet; (iii) a source of gas in fluidic communication with the gas inlet; (iv) a source of the eluent precursor fluid; and (b) a chromatography column disposed downstream of and in fluidic communication with the eluent outlet.
FILED	Friday, May 06, 2016
APPL NO	15/148988
ART UNIT	2854 — Printing/Measuring and Testing
CURRENT CPC	Separation B01D 15/166 (20130101) B01D 15/426 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4005 (20130101) G01N 30/34 (20130101) Original (OR) Class G01N 30/96 (20130101) G01N 2030/027 (20130101)
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10229068 — Tunable oblivious RAM

US 10229068	Wagh et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Sameer Wagh (Princeton, New Jersey); Paul Cuff (Lawrenceville, New Jersey); Prateek Mittal (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Sameer Wagh (Princeton, New Jersey); Paul Cuff (Lawrenceville, New Jersey); Prateek Mittal (Princeton, New Jersey)
ABSTRACT	An approach to implementing or configuring an Oblivious RAM (ORAM), which in addition to behaving as a RAM, provides a way to meet a specified degree of privacy in a manner that avoids applying unnecessary computation resources (computation time and/or storages space and/or data transfer) to achieve the specified degree of privacy. In this way, a tradeoff between privacy and computation resources may be tuned to address requirements of a particular application. This ability to tune this tradeoff is not found in other ORAM implementations, which in general aim to achieve complete privacy. In some implementations, the ORAM provides a constant bandwidth overhead compared to conventional RAMs, while achieving a statistical privacy as desired by the user.
FILED	Thursday, December 29, 2016
APPL NO	15/393822
ART UNIT	2136 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 12/1408 (20130101) Original (OR) Class G06F 21/00 (20130101) G06F 21/6245 (20130101) G06F 2212/402 (20130101)
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10229310 — High throughput partial wave spectroscopic microscopy and associated systems and methods

US 10229310	Backman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Vadim Backman (Evanston, Illinois); Hariharan Subramanian (Evanston, Illinois); John E. Chandler (Evanston, Illinois); Craig White (Evanston, Illinois); Jeremy D. Rogers (Evanston, Illinois); Lusik Cherkezyan (Evanston, Illinois)
ABSTRACT	The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (HT/A-PWS) instruments and systems capable of rapid acquisition of PWS Microscopic images and clinical, diagnostic, and research applications thereof.
FILED	Thursday, October 26, 2017
APPL NO	15/794101
ART UNIT	2483 — Recording and Compression
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/44 (20130101) G01J 3/1256 (20130101) G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/47 (20130101) G01N 2021/4709 (20130101) Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/16 (20130101) G02B 21/365 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00127 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/2354 (20130101) H04N 5/23212 (20130101)
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10229709 — Optical information storage medium

US 10229709	Singer et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S)	Kenneth D. Singer (Pepper Pike, Ohio); Chris Ryan (Ravenna, Ohio); Jie Shan (Cleveland Heights, Ohio); Joseph Lott (Edina, Minnesota); Christoph Weder (Duedingen, Switzerland); Brent Valle (Cleveland Heights, Ohio); Eric Baer (Cleveland Heights, Ohio)
ABSTRACT	An optical information storage medium includes a multilayer film that includes a plurality of extruded alternating active data storage layers and buffer layers, which separate the active data storage layers. The active data storage layers and buffer layers have thicknesses that allow the active data storage layers to be writable by non-linear or threshold writing processes to define data voxels within the active data storage layers that are readable by an optical reading device.
FILED	Thursday, February 11, 2016
APPL NO	15/041928
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Information Storage Based on Relative Movement Between Record Carrier and Transducer G11B 7/26 (20130101) G11B 7/0052 (20130101) G11B 7/0079 (20130101) G11B 7/242 (20130101) G11B 7/24027 (20130101) G11B 7/24038 (20130101) Original (OR) Class G11B 7/24056 (20130101) G11B 7/24065 (20130101) G11B 2007/0013 (20130101) G11B 2007/24624 (20130101) G11B 2007/240025 (20130101)
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10230208 — High-energy femtosecond light pulses based on a gain-switched laser diode

US 10230208	Fu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF)
APPLICANT(S)	Cornell University (Ithaca, New York)
ASSIGNEE(S)	Cornell University (Ithaca, New York)
INVENTOR(S)	Walter Fu (Ithaca, New York); Frank W. Wise (Ithaca, New York); Logan Wright (Ithaca, New York)
ABSTRACT	This disclosed subject matter allows short pulses with high peak powers to be obtained from seed pulses generated by a gain-switched diode. The gain-switched diode provides a highly stable source for optical systems such as nonlinear microscopy. The disclosed system preserves the ability to generate pulses at arbitrary repetition rates, or even pulses on demand, which can help reduce sample damage in microscopy experiments or control deliberate damage in material processing.
FILED	Wednesday, March 28, 2018
APPL NO	15/939250
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3526 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/06725 (20130101) H01S 3/06741 (20130101) H01S 3/06754 (20130101) H01S 3/08013 (20130101) Original (OR) Class H01S 5/0057 (20130101) H01S 5/0078 (20130101) H01S 5/0428 (20130101) H01S 5/0656 (20130101) H01S 2301/08 (20130101)
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10230240 — Low-frequency ancillary power grid services

US 10230240	Barooah et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Prabir Barooah (Gainesville, Florida); Sean Meyn (Gainesville, Florida)
ABSTRACT	Techniques for providing ancillary services to a power grid using customer premises such as commercial buildings. The techniques may involve receiving a regulation signal from a grid operator that is specific to a commercial building and modifying power consumption by at least one power consumption component in the building based on the regulation signal. The power consumption component may be a fan and/or a chiller of a Heating, Ventilation, and Air Conditioning (HVAC) system. The regulation signal may be tracked in a at least a portion of a frequency band from about 4 seconds to about 60 minutes, and the control architecture may depend on the portion of the frequency band.
FILED	Tuesday, October 21, 2014
APPL NO	15/031509
ART UNIT	2818 — Semiconductors/Memory
CURRENT CPC	Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/30 (20180101) F24F 11/46 (20180101) F24F 11/62 (20180101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/28 (20130101) Original (OR) Class H02J 2003/143 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 70/3266 (20130101) Y02B 70/3275 (20130101) Systems Integrating Technologies Related to Power Network Operation, Communication or Information Technologies for Improving the Electrical Power Generation, Transmission, Distribution, Management or Usage, i.e Smart Grids Y04S 20/242 (20130101) Y04S 20/244 (20130101)
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10230348 — Sub-network enhanced reflectionless filter topology

US 10230348	Morgan
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Astronomical Sciences (AST) National Radio Astronomy Observatory (NRAO) Federally Funded Research and Development Center (FFRDC) Operated by Associated Universities, Inc. (AUI)at Charlottesville, VA
APPLICANT(S)	Associated Universities, Inc. (Washington, District of Columbia)
ASSIGNEE(S)	Associated Universities, Inc. (Washington, District of Columbia)
INVENTOR(S)	Matthew Alexander Morgan (Earlysville, Virginia)
ABSTRACT	Reflectionless low-pass, high-pass, band-pass, band-stop, all-pass, and all-stop filters, as well as a method for designing such filters is disclosed, along with a method of enhancing the performance of such filters through the use of sub-networks to further modify and improve the frequency response. These filters preferably function by absorbing the stop-band portion of the spectrum rather than reflecting it back to the source, which has significant advantages in many different applications. The sub-networks preferably offer additional degrees of freedom by which the leakage through the parent filter may be cancelled or reinforced to alter cutoff sharpness, stop-rejection, or other measures of performance.
FILED	Thursday, July 06, 2017
APPL NO	15/643039
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/06 (20130101) H03H 7/09 (20130101) H03H 7/12 (20130101) H03H 7/38 (20130101) Original (OR) Class H03H 7/48 (20130101) H03H 7/0138 (20130101) H03H 7/1708 (20130101) H03H 7/1725 (20130101)
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10230419 — Adaptive techniques for full duplex communications

US 10230419	Bharadia et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Dinesh Bharadia (Stanford, California); Jung-Il Choi (Santa Clara, California); Mayank Jain (Sunnyvale, California); Sachin Katti (Stanford, California); Tae Min Kim (Stanford, California); Philip Levis (San Francisco, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
INVENTOR(S)	Dinesh Bharadia (Stanford, California); Jung-Il Choi (Santa Clara, California); Mayank Jain (Sunnyvale, California); Sachin Katti (Stanford, California); Tae Min Kim (Stanford, California); Philip Levis (San Francisco, California)
ABSTRACT	In one aspect there is provided a method. The method may include receiving a first analog radio frequency signal including a signal of interest and an interference signal caused by a second analog radio frequency signal transmitted in full duplex over a channel from which the first analog transmission is received; adjusting at least one of the first analog radio frequency signal and a portion of the second analog radio frequency signal to enable at least one of a reduction or an elimination of the interference signal in an output analog radio frequency signal; combining the first analog radio frequency signal and the portion of the second analog radio frequency signal to generate the output analog radio frequency signal characterized by at least the reduction or the elimination of the interference signal included in the output analog radio frequency signal; and providing the output analog radio frequency signal. Related apparatus, systems, methods, and articles are also described.
FILED	Wednesday, November 09, 2011
APPL NO	13/293072
ART UNIT	2465 — Multiplex and VoIP
CURRENT CPC	Transmission H04B 1/18 (20130101) H04B 1/56 (20130101) H04B 1/525 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 27/2626 (20130101) H04L 27/2647 (20130101)
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National Aeronautics and Space Administration (NASA)

10226768 — Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting

US 10226768	Chiou et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Aeronautics and Space Administration (NASA) National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Pei-Yu E. Chiou (Los Angeles, California); Ting-Hsiang S. Wu (Culver City, California); Michael A. Teitell (Tarzana, California)
ABSTRACT	In certain embodiments this invention provides a pulsed-laser triggered microfluidic switching mechanism that can achieve a switching time of 70 μs. This switching speed is two orders of magnitude shorter than that of the fastest switching mechanism utilized in previous μFACS.
FILED	Friday, April 08, 2016
APPL NO	15/094919
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0636 (20130101) B01L 2200/0652 (20130101) B01L 2300/123 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2400/0442 (20130101) B01L 2400/0454 (20130101) B01L 2400/0622 (20130101) B01L 2400/0655 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0001 (20130101) F16K 99/004 (20130101) F16K 99/0026 (20130101) F16K 99/0028 (20130101) F16K 99/0061 (20130101) F16K 2099/0084 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1459 (20130101) G01N 2015/149 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0391 (20150401) Y10T 137/2224 (20150401)
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10227469 — Polyamide aerogels

US 10227469	Williams et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America, as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Administrator of National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Jarrod C. Williams (Lakewood, Ohio); Mary Ann B. Meador (Strongsville, Ohio)
ABSTRACT	A polyamide aerogel and method of making the same is disclosed. The aerogel includes para-substituted monomers without a cross-linking agent.
FILED	Wednesday, August 17, 2016
APPL NO	15/238856
ART UNIT	1768 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 2101/0091 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/28 (20130101) C08J 9/0066 (20130101) C08J 9/286 (20130101) Original (OR) Class C08J 2201/0502 (20130101) C08J 2205/026 (20130101) C08J 2377/00 (20130101) C08J 2377/10 (20130101)
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10227950 — Thermoacoustic convertor

US 10227950	Dyson, Jr.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America, as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Administrator of National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Rodger W. Dyson, Jr. (Elyria, Ohio)
ABSTRACT	A thermoacoustic engine is provided that uses acoustic energy to operate a piston in a double-acting action. The acoustic energy is amplified as a sound wave travels through the thermoacoustic engine. The amplified acoustic energy is extracted and converted into usable electrical energy.
FILED	Monday, January 30, 2017
APPL NO	15/419571
ART UNIT	3748 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Hot Gas or Combustion-product Positive-displacement Engine Plants; Use of Waste Heat of Combustion Engines; Not Otherwise Provided for F02G 1/044 (20130101) Original (OR) Class F02G 1/055 (20130101) F02G 1/057 (20130101)
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10228197 — Variable heat rejection device

US 10228197	Cognata et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC)
APPLICANT(S)	Thomas Jaspero Cognata (Houston, Texas); Darren Hartl (College Station, Texas); Rubik Sheth (Houston, Texas); Craig Dinsmore (Houston, Texas)
ASSIGNEE(S)
INVENTOR(S)	Thomas Jaspero Cognata (Houston, Texas); Darren Hartl (College Station, Texas); Rubik Sheth (Houston, Texas); Craig Dinsmore (Houston, Texas)
ABSTRACT	A heat rejection system that employs temperature sensitive shape memory materials to control the heat rejection capacity of a vehicle to maintain a safe vehicle temperature. The technology provides for a wide range of heat rejection rates by varying the shape and thus effective properties of the heat rejection system in response to temperature. When employed as a radiator for crewed spacecraft thermal control this permits the use of higher freezing point, non-toxic thermal working fluids in single-loop thermal control systems for crewed vehicles in space and other extraterrestrial environments.
FILED	Friday, December 04, 2015
APPL NO	14/960301
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/50 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/00 (20130101) F28D 2021/0021 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 1/14 (20130101) F28F 5/00 (20130101) Original (OR) Class F28F 13/00 (20130101) F28F 2245/06 (20130101) F28F 2255/02 (20130101) F28F 2255/04 (20130101)
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10228465 — Steering mirror assist for laser pointing

US 10228465	Yang et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America, as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Guangning Yang (Clarksville, Maryland); Jeffrey R. Chen (Clarksville, Maryland)
ABSTRACT	An apparatus for improving a pointing capability of an optical pointing system includes a star tracker attitude control system for maintaining an alignment between the optical pointing system and a target, a beam steering mirror controlled by the star tracker attitude control system to direct an optical signal to impinge on the target, a fixed optical assembly configured to direct a portion of the optical signal from the bean steering mirror into a field of view of a star tracker telescope of the star tracker attitude control system, and a detector array for detecting the portion of the optical signal superimposed over a location in a current star scene in the star tracker telescope field of view, where the star tracker attitude control system is configured to operate the beam steering mirror to maintain the optical signal on the target by maintaining the superimposed signal on the location in the star scene.
FILED	Wednesday, June 14, 2017
APPL NO	15/622861
ART UNIT	2878 — Optics
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/66 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 23/02 (20130101) G02B 27/1006 (20130101) Transmission H04B 10/112 (20130101)
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10229604 — Flight awareness collaboration tool (FACT)

US 10229604	Mogford et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America as Represented by the National Aeronautics and Space Administration (NASA) (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Administrator of the NASA (Washington, District of Columbia)
INVENTOR(S)	Richard Hugh Mogford (Redwood City, California); Cody Allan Evans (San Jose, California)
ABSTRACT	A software tool assists airline dispatchers and other professionals in management of winter weather events at airports. The flight awareness collaboration tool (FACT) may gather pertinent weather information, air traffic information, airport information, and any other suitable information onto one display screen. FACT can be used by airline dispatchers to manage the airline fleet prior to during the day of a winter weather event, and may have built-in automation tools that can predict the impact of winter weather on airport capacity. FACT may be designed to support collaboration between the airline dispatcher, the air traffic control tower, the airport authority, and de-icing operators on the ground.
FILED	Friday, June 30, 2017
APPL NO	15/639807
ART UNIT	2144 — Graphical User Interface and Document Processing
CURRENT CPC	Electric Digital Data Processing G06F 3/0482 (20130101) G06F 3/04817 (20130101) Traffic Control Systems G08G 5/0026 (20130101) Original (OR) Class Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 5/14 (20130101) G09G 2354/00 (20130101) G09G 2380/12 (20130101)
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10230163 — Monopulse autotracking system for high gain antenna pointing

US 10230163	Adams et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Norman H. Adams (Fulton, Maryland); Hermann B. Sequeira (Severna Park, Maryland); Matthew G. Bray (Ellicott City, Maryland); Dipak K. Srinivasan (Highland, Maryland); Ron C. Schulze (Ellicott City, Maryland)
ABSTRACT	A method including receiving a monopulse transmission by a monopulse antenna determining an angle of arrival of the monopulse transmission, using processing circuitry operably coupled to the monopulse antenna, determining, using the processing circuitry, an angle error for a high gain antenna based on the angle of arrival of the monopulse transmission, and causing the positioning of the high gain antenna based on the angle error.
FILED	Friday, October 16, 2015
APPL NO	14/884996
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/288 (20130101) H01Q 3/02 (20130101) Original (OR) Class H01Q 25/02 (20130101)
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10230216 — Tunable multi-frequency terahertz quantum cascade laser source

US 10230216	Nguyen et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Admin of the National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Hung D. Nguyen (Lakewood, Ohio); Rainee N. Simons (North Olmsted, Ohio); Edwin G. Wintucky (Eastlake, Ohio)
ABSTRACT	A tunable QCL source that utilizes a full bandwidth of a broadband THz QCL, and produces a significantly large number of frequency channels, is provided. The tunable QCL source includes a grating router configured to receive a terahertz frequency from a tunable quantum cascade laser and generate a plurality of terahertz frequencies. The tunable QCL source also includes a waveguide controller configured to receive the plurality of terahertz frequencies from the grating router, and select a desired terahertz frequency from the plurality of terahertz frequencies to be outputted by a waveguide multiplexer.
FILED	Tuesday, April 28, 2015
APPL NO	14/698050
ART UNIT	2874 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3581 (20130101) Optical Elements, Systems, or Apparatus G02B 6/12011 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 2203/13 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/3401 (20130101) Original (OR) Class H01S 2302/02 (20130101) Multiplex Communication H04J 14/0267 (20130101) Selecting H04Q 2011/0016 (20130101)
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Department of Commerce (DOC)

10228490 — Hub and spoke system for detecting and locating gas leaks

US 10228490	Rieker et al.
FUNDED BY	Department of Commerce (DOC) Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado); The United States of America as represented by the Secretary of Commerce (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, As Represented by the Secretary of Commerce (Washington, District of Columbia); The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
INVENTOR(S)	Gregory B Rieker (Boulder, Colorado); Ian Coddington (Boulder, Colorado); Nathan R Newbury (Boulder, Colorado); Kuldeep Prasad (Vienna, Virginia); Anna Karion (Bethesda, Maryland)
ABSTRACT	A system for detecting gas leaks and determining their location and size. A data gathering portion of the system utilizes a hub and spoke configuration to collect path-integrated spectroscopic data over multiple open paths around an area. A processing portion of the system applies a high resolution transport model together with meteorological data of the area to generate an influence function of possible leak locations on gas detector measurement paths, and applies an inversion model to the influence function and the spectroscopic data to generate gas source size and location.
FILED	Wednesday, May 11, 2016
APPL NO	15/152543
ART UNIT	2857 — Printing/Measuring and Testing
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/42 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/202 (20130101) Meteorology G01W 1/00 (20130101) Original (OR) Class
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10228655 — Incoherent fluorescence digital holographic microscopy using transmission liquid crystal lens

US 10228655	Brooker et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	CellOptic, Inc. (Rockville, Maryland)
ASSIGNEE(S)	Cell Optic, Inc. (Rockville, Maryland)
INVENTOR(S)	Gary Brooker (Rockville, Maryland); Nisan Siegel (Silver Spring, Maryland); Joseph Rosen (Omer, Israel)
ABSTRACT	A new optical arrangement that creates high efficiency, high quality Fresnel Incoherent Correlation Holography (FINCH) holograms using transmission liquid crystal GRIN (TLCGRIN) diffractive lenses has been invented. This is in contrast to the universal practice in the field of using a reflective spatial light modulator (SLM) to separate sample and reference beams. Polarization sensitive TLCGRIN lenses enable a straight optical path, have 95% transmission efficiency, are analog devices without pixels and are free of many limitations of reflective SLM devices. An additional advantage is that they create an incoherent holographic system that is achromatic over a wide bandwidth. Two spherical beams created by the combination of a glass and a polarization sensitive TLCGRIN lenses interfere and a hologram is recorded by a digital camera. FINCH configurations which increase signal to noise ratios and imaging speed are also described.
FILED	Wednesday, January 03, 2018
APPL NO	15/861115
ART UNIT	2881 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/0068 (20130101) Holographic Processes or Apparatus G03H 1/06 (20130101) G03H 1/041 (20130101) G03H 1/0443 (20130101) Original (OR) Class G03H 5/00 (20130101) G03H 2001/005 (20130101) G03H 2001/0447 (20130101) G03H 2001/0452 (20130101) G03H 2222/24 (20130101) G03H 2222/31 (20130101) G03H 2223/22 (20130101) G03H 2225/22 (20130101)
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10230101 — Template electrode structures for depositing active materials

US 10230101	Loveness et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	Amprius, Inc. (Sunnyvale, California)
ASSIGNEE(S)	Amprius, Inc. (Sunnyvale, California)
INVENTOR(S)	Ghyrn E. Loveness (Mountain View, California); William S. Delhagen (San Francisco, California); Rainer Fasching (Mill Valley, California); Song Han (Foster City, California); Zuqin Liu (Sunnyvale, California)
ABSTRACT	Provided are examples of electrochemically active electrode materials, electrodes using such materials, and methods of manufacturing such electrodes. Electrochemically active electrode materials may include a high surface area template containing a metal silicide and a layer of high capacity active material deposited over the template. The template may serve as a mechanical support for the active material and/or an electrical conductor between the active material and, for example, a substrate. Due to the high surface area of the template, even a thin layer of the active material can provide sufficient active material loading and corresponding battery capacity. As such, a thickness of the layer may be maintained below the fracture threshold of the active material used and preserve its structural integrity during battery cycling.
FILED	Friday, September 18, 2015
APPL NO	14/859125
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/58 (20130101) H01M 4/66 (20130101) H01M 4/75 (20130101) H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/0428 (20130101) H01M 4/587 (20130101) H01M 4/661 (20130101) H01M 4/667 (20130101) H01M 4/1395 (20130101) H01M 10/0525 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/122 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49108 (20150115) Y10T 29/49115 (20150115)
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Department of Agriculture (USDA)

10226063 — Methods of decreasing the viscosity of a dietary fiber

US 10226063	Yadav et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia); AgriFiber Solutions, LLC (Mundelein, Illinois)
ASSIGNEE(S)	The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia); AgriFiber Solutions, LLC (Mundelein, Illinois)
INVENTOR(S)	Madhav P. Yadav (North Wales, Pennsylvania); Kyle A. Hanah (Mundelein, Illinois); Madhuvanti S. Kale (Mundelein, Pennsylvania)
ABSTRACT	Disclosed are methods of decreasing the viscosity of an aqueous suspension of a water insoluble or sparingly soluble dietary fiber (compared to the viscosity of the dietary fiber alone), involving mixing the dietary fiber with water and a soluble compound (e.g., polysaccharide having a molecular weight of about 500 Da to about 1,000 kDa and 1% solution viscosity of up to 10 mPa·s; or protein having a molecular weight of about 10 to about 500 kDa and a 1% solution viscosity of up to 10 mPa·s).
FILED	Thursday, October 01, 2015
APPL NO	14/872533
ART UNIT	1793 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/00 (20160801) Original (OR) Class A23L 29/25 (20160801) A23L 29/219 (20160801) A23L 29/238 (20160801) A23L 33/22 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101)
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10227664 — Cedar virus and methods of use

US 10227664	Wang et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA)
APPLICANT(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The State of Queensland, Department of Agriculture, Fisheries and Forestry (Brisbane, Australia); Commonwealth Scientific and Industrial Research Organization (Clayton South, Australia)
INVENTOR(S)	Linfa Wang (Wandana Heights, Australia); Glenn A. Marsh (Leopold, Australia); Hume Field (Ormiston, Australia); Christopher Broder (Silver Springs, Maryland)
ABSTRACT	The present invention is directed towards a novel virus, called Cedar Virus, and its methods of use.
FILED	Monday, June 13, 2016
APPL NO	15/180544
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/12 (20130101) A61K 2039/543 (20130101) Peptides C07K 14/005 (20130101) C07K 16/1027 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/18221 (20130101) C12N 2760/18222 (20130101) C12N 2760/18231 (20130101) C12N 2760/18234 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/701 (20130101) Original (OR) Class C12Q 2600/136 (20130101)
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Small Business Administration (SBA)

10226564 — Vascular access port systems and methods

US 10226564	Young et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Advent Access Pte. Ltd. (Singapore, Singapore)
ASSIGNEE(S)	Advent Access Pte. Ltd. (Singapore, Singapore)
INVENTOR(S)	Nathaniel P. Young (Salt Lake City, Utah); G. Doug Smith (Sandy, Utah); Mark A. Crawford (Sandy, Utah)
ABSTRACT	In certain systems disclosed herein, one or more of a first vascular access port and a second vascular access port can be selected by a customer. Each of the first and second vascular access ports can be implanted subcutaneously within a patient, and each can include a base configured to be attached to a vessel, a body that extends away from the base, and a guidance passageway that extends through the body and the base and includes a funnel region. A maximum height defined by the base and body of the second vascular access port can be greater than a maximum height defined by the base and body of the first vascular access port.
FILED	Monday, May 18, 2015
APPL NO	14/715553
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/0057 (20130101) A61B 17/3423 (20130101) A61B 2017/00641 (20130101) A61B 2017/00654 (20130101) A61B 2017/3425 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/3653 (20130101) Original (OR) Class A61M 1/3659 (20140204) A61M 1/3661 (20140204) A61M 39/0208 (20130101) A61M 2039/0223 (20130101) A61M 2039/0226 (20130101) A61M 2039/0238 (20130101) A61M 2205/0238 (20130101)
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10227419 — Antibodies targeting B-cell receptor complex membrane bound IgM and uses thereof

US 10227419	Welt et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Welt Bio-Molecular Pharmaceutlical, LLC (Armonk, New York)
ASSIGNEE(S)	Welt Bio-Molecular Pharmaceutical, LLC. (Armonk, New York)
INVENTOR(S)	Sydney Welt (Armonk, New York); David Kostyal (Akron, Ohio); Rachel S Welt (Armonk, New York); Virginia Raymond (Armonk, New York); Jonathan A Welt (Armonk, New York)
ABSTRACT	The present invention relates to antibodies targeting the membrane bound IgM (mIgM) of the B-cell receptor complex found in B-cell lymphomas and leukemias and uses thereof. Another aspect of the present invention is the use of anti-B-Cell mIgM antibodies in the treatment of Be-cell malignancies, including B-cell lymphomas and leukemias.
FILED	Tuesday, February 13, 2018
APPL NO	15/895386
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/2803 (20130101) C07K 16/4283 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/34 (20130101) C07K 2317/56 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/77 (20130101) C07K 2317/565 (20130101) C07K 2317/732 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/163 (20130101)
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Department of Homeland Security (DHS)

10228347 — High contrast signal to noise ratio device components

US 10228347	Barrall et al.
FUNDED BY	Department of Homeland Security (DHS) Science and Technology Directorate (DHS-ST) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	Geoffrey A. Barrall (San Diego, California); Eric N. Ervin (Salt Lake City, Utah); Prithwish Pal (San Diego, California)
ASSIGNEE(S)	Electronic BioSciences, Inc. (San Diego, California)
INVENTOR(S)	Geoffrey A. Barrall (San Diego, California); Eric N. Ervin (Salt Lake City, Utah); Prithwish Pal (San Diego, California)
ABSTRACT	Provided are device components, devices and methods characterized by a high contrast signal to noise ratio (CNR).
FILED	Friday, June 22, 2012
APPL NO	14/128587
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/447 (20130101) Original (OR) Class G01N 33/48721 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Veterans Affairs (DVA)

10226438 — Sobetirome in the treatment of myelination diseases

US 10226438	Scanlan et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Thomas S. Scanlan (San Francisco, California); Meredith Hartley (Portland, Oregon); Andrew Placzek (Portland, Oregon); Marco Righi (Rosignano, Italy); Dennis Bourdette (Portland, Oregon); Gail Marracci (Portland, Oregon); Priya Chaudhary (Portland, Oregon)
ASSIGNEE(S)	Oregon Health and Science University (Portland, Oregon); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Thomas S. Scanlan (San Francisco, California); Meredith Hartley (Portland, Oregon); Andrew Placzek (Portland, Oregon); Marco Righi (Rosignano, Italy); Dennis Bourdette (Portland, Oregon); Gail Marracci (Portland, Oregon); Priya Chaudhary (Portland, Oregon)
ABSTRACT	Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.
FILED	Wednesday, February 05, 2014
APPL NO	14/888577
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/0095 (20130101) A61K 31/192 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10229864 — Cryogenic integrated circuit having a heat sink coupled to separate ground planes through differently sized thermal vias

US 10229864	Loney et al.
FUNDED BY
APPLICANT(S)	Patrick Loney (Fairview Park, Ohio); Robert Miles Young (Ellicott City, Maryland); Daniel Robert Queen (Kensington, Maryland); Aaron Ashley Hathaway (Baltimore, Maryland); John X. Przybysz (Severna Park, Maryland)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Patrick Loney (Fairview Park, Ohio); Robert Miles Young (Ellicott City, Maryland); Daniel Robert Queen (Kensington, Maryland); Aaron Ashley Hathaway (Baltimore, Maryland); John X. Przybysz (Severna Park, Maryland)
ABSTRACT	An integrated circuit is provided that comprises a thermal sink layer, a first ground plane associated with a first set of circuits that have a first operational temperature requirement, and a first thermally conductive via that couples the first ground plane to the thermal sink layer. The circuit further comprises a second ground plane associated with a second set of circuits that have a second operational temperature requirement that is higher than the first operational temperature requirement, and a second thermally conductive via that couples the second ground plane to the thermal sink layer, wherein the first thermally conductive via has a greater volume of thermal conductive material than the second thermally conductive via to remove heat from the first set of circuits with less gradient than the second set of circuits.
FILED	Thursday, September 14, 2017
APPL NO	15/704919
ART UNIT	2814 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/3677 (20130101) H01L 23/3736 (20130101) H01L 23/4334 (20130101) Original (OR) Class H01L 27/18 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0204 (20130101) H05K 1/0207 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, March 12, 2019.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20190312.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

info@wayfinder.digital