FedInvent™ Patents

Patent Details for Tuesday, March 19, 2019

This page was updated on Monday, March 27, 2023 at 05:45 AM GMT

Department of Health and Human Services (HHS)

10231619 — Systems and methods to remove shadowgraphic flow projections in OCT angiography

US 10231619	Huang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon)
ASSIGNEE(S)	Oregon Health and Science University (Portland, Oregon)
INVENTOR(S)	David Huang (Portland, Oregon); Yali Jia (Portland, Oregon); Miao Zhong (Portland, Oregon)
ABSTRACT	Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is analyzed at the level of individual A-scans to classify signals as either flow or projection artifact. This classification information is then used to suppress projection artifacts in the three dimensional OCT angiography dataset.
FILED	Friday, December 09, 2016
APPL NO	15/374872
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/102 (20130101) A61B 3/1241 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 2207/10101 (20130101) G06T 2207/20182 (20130101) G06T 2207/30041 (20130101) G06T 2207/30104 (20130101)
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10231626 — Imaging system and method for fluorescence guided surgery

US 10231626	Steinbach et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Paul Steinbach (San Diego, California); Quyen T. Nguyen (La Jolla, California); Roger Y. Tsien (La Jolla, California)
ABSTRACT	Imaging systems for fluorescence guided surgery are provided. An imaging system comprises a light source unit for providing one or more illumination and excitation lights to a target, a detection unit for detecting reflectance and fluorescence from the target, an optical train for directing the one or more illumination and excitation lights from the light source unit to the target and for directing the reflectance and fluorescence from the target to the detection unit, and a control unit for controlling the light source unit and the detection unit. Imaging methods for fluorescence guided surgery are also provided.
FILED	Monday, March 17, 2014
APPL NO	14/216704
ART UNIT	3737 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/0062 (20130101) A61B 5/0071 (20130101) Original (OR) Class A61B 5/0077 (20130101)
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10231636 — Opto-electrical device and method for artifact reduction

US 10231636	Seymour et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Neuronexus Technologies, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)	NeuroNexus Technologies, Inc. (Ann Arbor, Michigan)
INVENTOR(S)	John P. Seymour (Ann Arbor, Michigan); Jongeun Jeon (Ann Arbor, Michigan); Nicholas Hewitt (Chelsea, Michigan); Abeer Khurram (Ypsilanti, Michigan)
ABSTRACT	An optical electrode having a plurality of electrodes, including a recording electrode having a roughened surface and an optical light source configured to emit light, wherein at least a portion of the light impinges on the recording electrode. Also disclosed are methods of producing an optical electrode and an opto-electronic neural interface system.
FILED	Monday, October 09, 2017
APPL NO	15/728251
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/04001 (20130101) Original (OR) Class A61B 5/6847 (20130101) A61B 5/6868 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0534 (20130101) A61N 5/0622 (20130101) A61N 2005/0612 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49826 (20150115) Y10T 29/49886 (20150115)
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10231656 — Systems and methods for measuring oxygenation

US 10231656	Esenaliev et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	NONINVASIX, INC. (Galveston, Texas)
ASSIGNEE(S)	Noninvasix, Inc. (Galveston, Texas); The Board of Regents of The University of Texas (Austin, Texas)
INVENTOR(S)	Rinat Esenaliev (League City, Texas); Donald S. Prough (Galveston, Texas); Yuriy Petrov (Galveston, Texas); Irene Petrov (Galveston, Texas); George Saade (Houston, Texas); Gayle L. Olson (Galveston, Texas); Tommy G. Cooper (Friendswood, Texas)
ABSTRACT	Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.
FILED	Wednesday, July 08, 2015
APPL NO	14/794037
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0095 (20130101) A61B 5/742 (20130101) A61B 5/1459 (20130101) A61B 5/1464 (20130101) A61B 5/6814 (20130101) A61B 5/6875 (20130101) A61B 5/14542 (20130101) Original (OR) Class A61B 5/14553 (20130101) A61B 2562/0271 (20130101)
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10231687 — Method and apparatus for enhanced X-ray computing arrays

US 10231687	Kahn et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Triple Ring Technologies, Inc. (Newark, California)
ASSIGNEE(S)	Triple Ring Technologies, Inc. (San Jose, California)
INVENTOR(S)	Paul Anthony Kahn (Los Gatos, California); Christopher William Ellenor (Millbrae, California); Tobias Funk (Martinez, California); Oleg John Konings (San Francisco, California)
ABSTRACT	An x-ray imaging system utilizes enhanced computing arrays. A plurality of x-ray illumination source positions are utilized to produce x-ray radiation at each of the x-ray illumination source positions and to project x-ray radiation towards an object. A detector detects x-ray radiation from the object and transmits detector images for each of the illumination source positions. A memory buffer stores the detector images from the detector. A graphics processing unit formats the detector images and constructs a complete frame data set with the detector images for each of the illumination source positions. Another graphics processing unit receives the complete frame data set and performs image reconstruction on the complete frame data set.
FILED	Friday, October 16, 2015
APPL NO	14/885166
ART UNIT	2884 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/06 (20130101) A61B 6/461 (20130101) A61B 6/4028 (20130101) A61B 6/4071 (20130101) A61B 6/5211 (20130101) Original (OR) Class
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10231706 — Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

US 10231706	Chen et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Zhongping Chen (Irvine, California); Wenjuan Qi (Irvine, California); Rui Li (Irvine, California)
ABSTRACT	An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PRARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the returned ultrasound signal and the measured frequency dependence of the returned PR-ARF-OCE optical coherence elastographic signal to quantitatively measure the mechanical properties of the identified tissues with both spectral and spatial resolution using enhanced materials response at mechanically resonant frequencies.
FILED	Friday, March 14, 2014
APPL NO	14/213904
ART UNIT	3737 — Audio Signals
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0035 (20130101) A61B 5/0066 (20130101) A61B 5/02007 (20130101) A61B 8/12 (20130101) A61B 8/445 (20130101) A61B 8/485 (20130101) Original (OR) Class A61B 8/4416 (20130101) A61B 8/5261 (20130101)
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10231712 — Dual mode ultrasound transducer (DMUT) system and method for controlling delivery of ultrasound therapy

US 10231712	Ebbini et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Emad S. Ebbini (Edina, Minnesota); Andrew J. Casper (Eau Claire, Wisconsin); Dalong Liu (Saint Paul, Minnesota); John R. Ballard (Saint Bonifacius, Minnesota)
ASSIGNEE(S)	REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
INVENTOR(S)	Emad S. Ebbini (Edina, Minnesota); Andrew J. Casper (Eau Claire, Wisconsin); Dalong Liu (Saint Paul, Minnesota); John R. Ballard (Saint Bonifacius, Minnesota)
ABSTRACT	A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multichannel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multimodal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data.
FILED	Thursday, June 09, 2011
APPL NO	13/702813
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/54 (20130101) Original (OR) Class A61B 8/485 (20130101) A61B 8/0816 (20130101) A61B 8/4488 (20130101) A61B 8/5223 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) A61N 2007/027 (20130101) A61N 2007/0052 (20130101) A61N 2007/0095 (20130101)
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10231820 — Fabrication of vascularized tissue using microfabricated two-dimensional molds

US 10231820	Vacanti et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Joseph P. Vacanti (Boston, Massachusetts); Young-Moon M. Shin (Somerville, Massachusetts); Jennifer Ogilvie (San Francisco, California); Alexander Sevy (Houston, Texas); Tomoyuki Maemura (Boston, Massachusetts); Osamu Ishii (Arlington, Massachusetts); Mohammad R. Kaazempur-Mofrad (Cambridge, Massachusetts); Jeffrey T. Borenstein (Holliston, Massachusetts); Kevin R. King (Western Springs, Illinois); Chiao-Chun Wang (Baltimore, Maryland); Eli Weinberg (Needham, Massachusetts)
ABSTRACT	Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.
FILED	Thursday, November 17, 2016
APPL NO	15/354865
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/062 (20130101) Original (OR) Class A61F 2240/004 (20130101) A61F 2240/005 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/58 (20130101) A61L 27/3604 (20130101) A61L 27/3804 (20130101) A61L 27/3808 (20130101) A61L 27/3891 (20130101) A61L 27/3895 (20130101) A61L 2300/64 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/06 (20130101) C12M 23/30 (20130101) C12M 25/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0697 (20130101) C12N 2533/12 (20130101) C12N 2533/30 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49826 (20150115)
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10231949 — Inhibition of cancer cell motility

US 10231949	Bergan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	Raymond C. Bergan (Chicago, Illinois); Karl A. Scheidt (Evanston, Illinois); Li Xu (Evanston, Illinois)
ABSTRACT	Provided herein are compositions and methods for inhibiting cancer cell motility and/or metastasis. In particular embodiments, KBU2046 (or an analog thereof) and one or more additional therapies (e.g., cancer therapies (e.g., hormone therapies and chemotherapies) are provided to inhibit cancer cell motility, inhibit metastasis, and/or treat cancer (e.g., prostate cancer, lung cancer, breast cancer, colon cancer, etc.).
FILED	Tuesday, December 12, 2017
APPL NO	15/839322
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/167 (20130101) A61K 31/353 (20130101) Original (OR) Class A61K 31/353 (20130101) A61K 31/4188 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10231952 — Use of arginine vasopressin receptor antagonists for the treatment of prostate cancer

US 10231952	Burnstein
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute on Aging (NIA)
APPLICANT(S)	UNIVERSITY OF MIAMI (Miami, Florida)
ASSIGNEE(S)	UNIVERSITY OF MIAMI (Miami, Florida)
INVENTOR(S)	Kerry L. Burnstein (Miami, Florida)
ABSTRACT	Described herein are methods of decreasing the proliferation of prostate cancer cells in a mammalian subject by administering to a subject in need thereof a composition comprising an AVPR antagonist in amount effective to decrease proliferation of the cancer cells. Also provided are methods of inducing prostate cancer cell death (or decreasing invasion migration of the prostate cancer cells) in a mammalian subject by administering to a subject in need thereof a composition comprising an AVPR antagonist.
FILED	Tuesday, July 28, 2015
APPL NO	14/811354
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/58 (20130101) A61K 31/58 (20130101) A61K 31/404 (20130101) Original (OR) Class A61K 31/404 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10231966 — Combination therapy for treating pulmonary hypertension

US 10231966	Zisman
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Pulmokine, Inc. (Rensselaer, New York)
ASSIGNEE(S)	Pulmokine, Inc. (Rensselaer, New York)
INVENTOR(S)	Lawrence S. Zisman (Slingerlands, New York)
ABSTRACT	The present disclosure describes a method of treating pulmonary disorders, such as pulmonary arterial hypertension, using a combination of a PDGF receptor kinase inhibitor, PDEV inhibitor, and an endothelin receptor antagonist. The compounds can inhibit cell growth and proliferation and target the underlying pathology of PAH.
FILED	Friday, October 27, 2017
APPL NO	15/796083
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0075 (20130101) A61K 31/497 (20130101) Original (OR) Class A61K 31/505 (20130101) A61K 31/4985 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101)
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10231991 — Biomaterials comprising hyaluronic acid binding peptides and extracellular matrix binding peptides for hyaluronic acid retention and tissue engineering applications

US 10231991	Singh et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Anirudha Singh (Baltimore, Maryland); Shimon Unterman (Brookline, Massachusetts); Michael Corvelli (Baltimore, Maryland); Jennifer Elisseeff (Baltimore, Maryland)
ABSTRACT	The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (HA). The biomaterial compositions utilize small HA binding peptides and extracellular matrix binding (ECM) peptides that are tethered to synthetic biocompatible polymers. When tethered to the polymers, the peptide region allows the polymers to bind to HA and to tissues such as cartilage. The novel biomaterial compositions can be used to coat or chemically modify cartilage or tissues with a biologically compatible polymer having HA binding peptides, which allow HA to bind to the surface of the cartilage or tissues. Methods of using same are also provided.
FILED	Wednesday, July 16, 2014
APPL NO	14/906111
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 31/728 (20130101) Original (OR) Class A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 47/60 (20170801) A61K 47/6957 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/20 (20130101) A61L 27/227 (20130101) A61L 2400/10 (20130101) A61L 2400/18 (20130101) A61L 2430/06 (20130101) A61L 2430/16 (20130101) Compositions of Macromolecular Compounds C08L 5/08 (20130101)
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10231993 — Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders

US 10231993	Pun et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington)
ASSIGNEE(S)	University of Washington through its Center for Commercialization (Seattle, Washington)
INVENTOR(S)	Suzie H. Pun (Seattle, Washington); Leslie Chan (Seattle, Washington); Nathan J. White (Seattle, Washington)
ABSTRACT	A biocompatible polymer to which a plurality of clot-modulating peptides (CMPs) are bound. The polymer comprises repeating units of hydrophilic monomers and display monomers to which the CMPs are bound. For example, the CMPs can be fibrin binding peptides (FBPs) that enhance clot formation by cross-linking that occurs within and between fibers by the plurality of fibrin-binding peptides during fibrin polymerization. The polymers of the invention can be used to modulate clotting in a variety of ways via multivalent display of fibrin-binding peptides and other clot-binding and clot-modulating moieties on polymer or co-polymer backbones. In addition to clot-modulating moieties, imaging agents and therapeutic agents can be conjugated to the polymers to facilitate imaging of blood flow and thrombosis, and for treatment of clotting-related disorders.
FILED	Friday, June 27, 2014
APPL NO	14/392359
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/787 (20130101) Original (OR) Class A61K 38/36 (20130101) Peptides C07K 14/00 (20130101)
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10231997 — Exosome-based therapeutics against neurodegenerative disorders

US 10231997	Pusic et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) National Institute of Child Health and Human Development (NICHD) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)	The University of Chicago (Chicago, Illinois)
INVENTOR(S)	Kae M. Pusic (Chicago, Illinois); Yelena Y. Grinberg (Chicago, Illinois); Richard P. Kraig (Chicago, Illinois); Aya D. Pusic (Chicago, Illinois)
ABSTRACT	Methods and compositions involving exosomes or lipid nanovesicles are provided. For example, certain aspects relate to compositions comprising exosomes obtained from cells that have been induced to undergo oxidative stress or stimulated. Furthermore, some aspects of the invention provide methods of treating a subject at risk or having a demyelinating disorder using the compositions.
FILED	Thursday, August 15, 2013
APPL NO	14/420680
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/5068 (20130101) A61K 31/7088 (20130101) A61K 35/15 (20130101) Original (OR) Class A61K 35/30 (20130101) A61K 35/35 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) C12N 15/88 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101)
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10231998 — Method for chemoselection

US 10231998	Kasahara et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Noriyuki Kasahara (Miami, Florida); Robert H. Schiestl (Encino, California); Katrin Hacke (Los Angeles, California); Akos Szakmary (Vienna, Austria); Gay M. Crooks (Sherman Oaks, California)
ABSTRACT	A method of radiation-free hematopoietic stem cell (HSC) transplantation comprises administering to a mammalian subject one or two doses of 2 to 10 mg/kg body weight of a purine base analog, such as 6TG as a pre-conditioning step. The method further comprises engrafting into the subject hypoxanthine-guanine phosphoribosyltransferase (HPRT)-deficient donor HSCs within 48 to 72 hours of the pre-conditioning step; and administering to the subject about 1 to 5 mg/kg of the purine base analog every two to four days for two to eight weeks following the engrafting step. The method is performed in the absence of pre-conditioning via radiation. The subject is therefore not treated with myeloablative radiation in preparation for transplantation, and thus the subject is free of myeloablative radiation-induced toxicity.
FILED	Friday, June 16, 2017
APPL NO	15/625819
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/522 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 35/28 (20130101) A61K 2035/124 (20130101) A61K 2300/00 (20130101)
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10232001 — Selection and use of lactic acid bacteria preventing bone loss in mammals

US 10232001	Connolly et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH)
APPLICANT(S)	BIOGAIA AB (Stockholm, Sweden); Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S)	BioGaia AB (Stockholm, Sweden); Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S)	Eamonn Connolly (Lidingö, Sweden); Robert Allen Britton (East Lansing, Michigan); Laura Rae McCabe (Haslett, Michigan)
ABSTRACT	The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been selected according to the presented method. The selection method is based on the strain's capability of reestablishing an altered microbial community to normal and/or harboring at least one of four specific SNPs.
FILED	Monday, March 12, 2018
APPL NO	15/918207
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/135 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2002/00 (20130101) A23V 2200/306 (20130101) Indexing Scheme Relating to Lactic or Propionic Acid Bacteria Used in Foodstuffs or Food Preparation A23Y 2220/00 (20130101) A23Y 2220/71 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/747 (20130101) Original (OR) Class A61K 2035/11 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 2600/16 (20130101) C12Q 2600/156 (20130101)
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10232002 — Oncolytic HSV1 vectors and methods of using the same

US 10232002	Nakashima et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
ASSIGNEE(S)	THE BRIGHAM AND WOMEN'S HOSPITAL (Boston, Massachusetts); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
INVENTOR(S)	Hiroshi Nakashima (Framingham, Massachusetts); Ennio Antonio Chiocca (Powell, Ohio)
ABSTRACT	Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides an oncolytic virus capable of killing target cells, such as tumor cells. In various embodiments presented herein, the oncolytic viruses described herein are suitable for treatment of several types of cancer, including glioblastoma.
FILED	Thursday, November 14, 2013
APPL NO	14/442632
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/768 (20130101) Original (OR) Class A61K 38/1709 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/16043 (20130101)
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10232016 — Methods for treating congestive heart failure

US 10232016	Marchionni et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Aeronautics and Space Administration (NASA)
APPLICANT(S)	Acorda Therapeutics, Inc. (Ardsley, New York); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Acorda Therapeutics, Inc. (Ardsley, New York); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S)	Mark Marchionni (Arlington, Massachusetts); Ralph Kelly (Chestnut Hill, Massachusetts); Beverly Lorell (Brookline, Massachusetts); Douglas B. Sawyer (Portland, Maine)
ABSTRACT	The invention features methods of treating or preventing congestive heart failure by administering a polypeptide containing an epidermal growth factor-like domain encoded by a neuregulin gene.
FILED	Thursday, September 03, 2015
APPL NO	14/844475
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1883 (20130101) Original (OR) Class A61K 39/395 (20130101) A61K 39/395 (20130101) A61K 2300/00 (20130101)
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10232023 — Methods for treatment of and prophylaxis against inflammatory disorders

US 10232023	Yost et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	THE UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
INVENTOR(S)	Christian Con Yost (North Salt Lake, Utah); Guy A. Zimmerman (Salt Lake City, Utah); Andrew S. Weyrich (Salt Lake City, Utah)
ABSTRACT	An isolated and purified peptide, neonatal NET-inhibitory Factor (nNIF), is disclosed. Methods for treatment of and prophylaxis against inflammatory disorders are also disclosed, including methods of treatment of and prophylaxis against inflammatory disorders comprising administering NET-inhibitory peptides (NIPs), which may be a nNIF, a pharmaceutically acceptable salt of a nNIF, a nNIF analog, a pharmaceutically acceptable salt of a nNIF analog, a nNIF-Related Peptide (nNRP), including the nNRP, Cancer-Associated SCM-Recognition, Immune Defense Suppression, and Serine Protease Protection Peptide (CRISPP), a pharmaceutically acceptable salt of a nNRP, a nNRP analog, or a pharmaceutically acceptable salt of a nNRP analog, to an individual.
FILED	Friday, February 24, 2017
APPL NO	15/441982
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/57 (20130101) Original (OR) Class A61K 38/1709 (20130101) Peptides C07K 14/4703 (20130101) Technologies for Adaptation to Climate Change Y02A 50/385 (20180101) Y02A 50/387 (20180101) Y02A 50/473 (20180101)
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10232031 — Influenza virus reassortment

US 10232031	Dormitzer et al.
FUNDED BY	Department of Health and Human Services (HHS) Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA)
APPLICANT(S)	Seqirus UK Limited (Berkshire, United Kingdom); Synthetic Genomics, Inc. (La Jolla, California)
ASSIGNEE(S)	Seqirus UK Limited (Berkshire, United Kingdom); Synthetic Genomics, Inc. (La Jolla, California)
INVENTOR(S)	Philip Dormitzer (Cambridge, Massachusetts); Peter Mason (Cambridge, Massachusetts); Pirada Suphaphiphat (Cambridge, Massachusetts); Raul Gomila (Cambridge, Massachusetts)
ABSTRACT	New influenza donor strains for the production of reassortant influenza B viruses are provided.
FILED	Thursday, March 13, 2014
APPL NO	14/775066
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16134 (20130101) C12N 2760/16234 (20130101) C12N 2760/16251 (20130101) C12N 2760/16252 (20130101)
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10232034 — Compositions comprising CH505 envelopes, and trimers

US 10232034	Haynes et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Duke University (Durham, North Carolina); Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	DUKE UNIVERSITY (Durham, North Carolina); LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Barton F. Haynes (Durham, North Carolina); Hua-Xin Liao (Durham, North Carolina); Bette T. Korber (Los Alamos, New Mexico); Peter T. Hraber (Los Alamos, New Mexico)
ABSTRACT	In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
FILED	Friday, September 25, 2015
APPL NO	15/513539
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4706 (20130101) A61K 39/12 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 47/4833 (20130101) A61K 47/48276 (20130101) A61K 47/48338 (20130101) A61K 47/48815 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) A61K 2039/627 (20130101) A61K 2039/6018 (20130101) Peptides C07K 14/70578 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16134 (20130101)
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10232035 — Conditionally replication deficient herpes virus and use thereof in vaccines

US 10232035	Mahalingam et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado)
ASSIGNEE(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S)	Ravi Mahalingam (Aurora, Colorado); Donald Gilden (Greenwood Village, Colorado)
ABSTRACT	The present invention is directed to a mutated recombinant herpesvirus, e.g., varicella zoster virus (VZV) and simian varicella virus strains or HSV-1 or HSV-2 strains, vaccines containing, and methods for the construction and use thereof to elicit protective immunity in susceptible individuals, wherein the particular herpesvirus is modified to render the virus replication deficient, i.e., the virus substantially or only replicates under defined conditions, by the incorporation of at least one destabilization domain in or fused to a gene essential for herpesvirus replication. The invention particularly relates to the use of the resultant conditionally replication defective herpesviruses, e.g., a mutated VZV strains in vaccine compositions in order to immunize individuals against herpesvirus infection, e.g., in the case of VZV chickenpox and to protect against shingles and zoster, or to prevent the reactivation of VZV or other herpesvirus reactivation and the onset of shingles or another condition relating to the reactivation of another herpesvirus infection, e.g., as a consequence of advanced age, stress, inflammation, drug or other therapy, cancer, or immunodeficiency such as in HIV-AIDS or other diseases resulting in impaired T and/or B cell immunity.
FILED	Wednesday, September 11, 2013
APPL NO	14/427918
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/25 (20130101) Original (OR) Class A61K 39/245 (20130101) A61K 2039/70 (20130101) A61K 2039/544 (20130101) A61K 2039/5254 (20130101) Peptides C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16034 (20130101) C12N 2710/16634 (20130101) C12N 2710/16722 (20130101) C12N 2710/16734 (20130101) C12N 2710/16762 (20130101)
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10232037 — Supramolecular hydrogel of fMLF-based molecules and use thereof

US 10232037	Zhao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	BRANDEIS UNIVERSITY (Waltham, Massachusetts); CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
ASSIGNEE(S)	Brandeis University (Waltham, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Fan Zhao (Waltham, Massachusetts); Jingyu Li (Boston, Massachusetts); Hongbo R. Luo (Boston, Massachusetts); Bing Xu (Waltham, Massachusetts)
ABSTRACT	The invention relates to the application of peptides that can self-assemble to form supramolecular nanofibrils and hydrogels, hydrogel compositions containing the self-assembled supramolecular nanofibrils, and methods of uses and making the hydrogel compositions.
FILED	Thursday, May 29, 2014
APPL NO	15/115385
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) A01N 25/34 (20130101) A01N 37/46 (20130101) A01N 37/46 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 38/00 (20130101) A61K 38/06 (20130101) A61K 38/07 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/16 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/572 (20130101) A61K 2039/575 (20130101) A61K 2039/55516 (20130101) Peptides C07K 5/0802 (20130101) C07K 5/1002 (20130101) C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/00 (20130101) C07K 14/001 (20130101) C07K 2319/00 (20130101)
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10232039 — Compositions and methods for the treatment of tissue fibrosis

US 10232039	Noble et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Paul W. Noble (Chapel Hill, North Carolina); Dianhua Jiang (Chapel Hill, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Paul W. Noble (Chapel Hill, North Carolina); Dianhua Jiang (Chapel Hill, North Carolina)
ABSTRACT	Provided are methods of treating tissue fibrosis comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a hyaluron synthase (HAS) or CD44. Further provided are methods of inhibiting myofibroblast invasion, or of reducing matrix deposition in the lung, the methods comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a HAS or CD44. Further provided are methods of determining the progression of pulmonary fibrosis, the methods comprising determining the level of matrix metalloproteinase expression in a cell, and comparing the level of expression to that of a control cell, wherein an increased level of expression relative to the control cell indicates progression of the disease.
FILED	Thursday, April 12, 2012
APPL NO	14/111338
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 39/3955 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/8146 (20130101)
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10232050 — Multi-functional particles and methods of using the same

US 10232050	Lee
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Clemson University (Anderson, South Carolina)
ASSIGNEE(S)	Clemson University (Clemson, South Carolina)
INVENTOR(S)	Jeoung Soo Lee (Clemson, South Carolina)
ABSTRACT	Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles.
FILED	Friday, December 11, 2015
APPL NO	14/966614
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/4015 (20130101) A61K 47/482 (20130101) A61K 47/488 (20130101) Original (OR) Class A61K 47/48561 (20130101) Peptides C07K 16/286 (20130101)
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10232055 — RNA containing modified nucleosides and methods of use thereof

US 10232055	Kariko et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
INVENTOR(S)	Katalin Kariko (Rydal, Pennsylvania); Drew Weissman (Wynnewood, Pennsylvania)
ABSTRACT	This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules.
FILED	Monday, October 31, 2016
APPL NO	15/339363
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/50 (20130101) A61K 38/177 (20130101) A61K 38/1816 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0041 (20130101) A61K 48/0066 (20130101) Original (OR) Class A61K 48/0075 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Peptides C07K 14/47 (20130101) C07K 14/505 (20130101) C07K 14/4712 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/85 (20130101) C12N 15/117 (20130101) C12N 2310/17 (20130101) C12N 2310/33 (20130101) C12N 2310/3341 (20130101) C12N 2800/95 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Enzymes C12Y 305/04004 (20130101)
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10232057 — Targeting cancer cells and tissue using filamentous plant virus particles

US 10232057	Steinmetz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Nicole F. Steinmetz (Cleveland Heights, Ohio); Sourabh Skukla (Mayfield Heights, Ohio)
ABSTRACT	A filamentous plant virus carrier comprising a filamentous plant virus particle that has been modified to carry an imaging agent or cytotoxic compound is described. The filamentous plant virus carrier can be used in a method of targeting cancer cells and tissue by administering it to a subject. Cancer tissue targeted by the filamentous plant virus carrier can be imaged using an imaging agent, or treated using a cytotoxic compound.
FILED	Friday, May 31, 2013
APPL NO	15/306786
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/6901 (20170801) A61K 49/0002 (20130101) A61K 49/005 (20130101) Original (OR) Class A61K 49/0021 (20130101) A61K 49/0097 (20130101)
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10232080 — Mesenchymal stem cell-mediated function tooth regeneration

US 10232080	Shi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Songtao Shi (Los Angeles, California); Wataru Sonoyama (Los Angeles, California); Takayoshi Yamaza (Los Angeles, California); Songlin Wang (Los Angeles, California)
ASSIGNEE(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
INVENTOR(S)	Songtao Shi (Los Angeles, California); Wataru Sonoyama (Los Angeles, California); Takayoshi Yamaza (Los Angeles, California); Songlin Wang (Los Angeles, California)
ABSTRACT	A method for reconstructing a functional tooth by using a carrier loaded with a plurality of mesenchymal stem cells including at least one of a stem cell derived from Apical Papilla (SCAP), Periodontal Ligament Stem Cells (PDLSC), and Dental Pulp Stem Cells (DPSC). The mesenchymal stem cell loaded carrier is planted into a site within a subject's oral cavity to form a bio-root upon which a crown may be affixed, The mesenchymal stem cells will develop new periodontal tissues to stabilize the bio-root. Methods disclosed herein are particularly beneficial for subjects lacking good bone structures for conventional crown treatments.
FILED	Thursday, November 29, 2007
APPL NO	12/514051
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 8/0006 (20130101) A61C 8/0043 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/12 (20130101) A61L 27/34 (20130101) Original (OR) Class A61L 27/34 (20130101) A61L 27/3834 (20130101) A61L 27/3865 (20130101) A61L 27/3891 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101)
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10232156 — Drug delivery methods and systems

US 10232156	Netzel et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Chrono Therapeutics Inc. (Hayward, California)
ASSIGNEE(S)	Chrono Therapeutics Inc. (Hayward, California)
INVENTOR(S)	Zita S. Netzel (Los Altos, California); Gary Stacey (Cambridge, United Kingdom); Alexander David Norman (Cambridge, United Kingdom); Congyi Huang (Cambridge, United Kingdom); Timothy Charles Frearson (Hartley Wintney, United Kingdom); Charles Frazer Kilby (Cambridge, United Kingdom); Patrick H. Ruane (Dublin, California); Alan J. Levy (Bellevue, Washington); Kevin W. Gelston (Moraga, California); Jennifer Darmour (Seattle, Washington); Jenny E. Hapgood (Tacoma, Washington); David Evans Roth (Issaquah, Washington); Ronald A. Overbeck (Winthrop, Washington); Ling-Kang Tong (Hayward, California)
ABSTRACT	A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
FILED	Friday, September 08, 2017
APPL NO	15/699382
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/145 (20130101) A61M 5/1456 (20130101) A61M 5/14244 (20130101) A61M 5/14248 (20130101) A61M 5/16877 (20130101) A61M 5/16881 (20130101) A61M 35/00 (20130101) Original (OR) Class A61M 2005/14268 (20130101) A61M 2005/14506 (20130101) A61M 2005/14573 (20130101)
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10232368 — High-speed on demand droplet generation and single cell encapsulation driven by induced cavitation

US 10232368	Chiou et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Aeronautics and Space Administration (NASA) National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Pei-Yu E. Chiou (Los Angeles, California); Ting-Hsiang S. Wu (Culver City, California); Sung-Yong Park (Kent Vale, Singapore); Michael A. Teitell (Tarzana, California)
ABSTRACT	Methods and devices for the formation of droplets of a first fluid in a second fluid and the encapsulation of particles or cells within such droplets are disclosed. Impetus for droplet formation is provided by the creation of a transient bubble, which may be induced using a pulsed laser. Droplet volume and the frequency at which droplets are formed can be controlled by modulation of the pulsed laser. The disclosed methods and devices are particularly suitable for use in microfluidic devices.
FILED	Monday, November 02, 2015
APPL NO	14/930054
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/04 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 2200/0636 (20130101) B01L 2200/0647 (20130101) B01L 2200/0668 (20130101) B01L 2200/0673 (20130101) B01L 2300/0816 (20130101) B01L 2400/0403 (20130101) B01L 2400/0442 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/10 (20130101) G01N 21/64 (20130101) G01N 29/2418 (20130101) G01N 2015/1481 (20130101) G01N 2291/02433 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 11/13 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) Y10T 137/2496 (20150401)
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10232371 — Microfluidic devices and methods for cell processing

US 10232371	Collins
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	John Collins (Irvine, California)
ASSIGNEE(S)	Biopico Systems Inc (Irvine, California)
INVENTOR(S)	John Collins (Irvine, California)
ABSTRACT	Microfluidic devices and methods that use cells such as cancer cells, stem cells, blood cells for preprocessing, sorting for various biodiagnostics or therapeutical applications are described. Microfluidics electrical sensing such as measurement of field potential or current and phenomena such as immiscible fluidics, inertial fluidics are used as the basis for cell and molecular processing (e.g., characterizing, sorting, isolation, processing, amplification.) of different particles, chemical compositions or biospecies (e.g., different cells, cells containing different substances, different particles, different biochemical compositions, proteins, enzymes etc.). Specifically, the present invention discloses a number of sorting schemes for stem cells, whole blood and circulating tumor cells, and extracting serum from whole blood.
FILED	Friday, July 24, 2015
APPL NO	14/808703
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 7/52 (20130101) B01L 2200/0652 (20130101) B01L 2200/0668 (20130101) B01L 2200/0673 (20130101) B01L 2300/0832 (20130101) B01L 2300/0861 (20130101) B01L 2300/0864 (20130101) B01L 2300/0883 (20130101) B01L 2300/1822 (20130101) B01L 2400/086 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 15/1056 (20130101) G01N 33/4833 (20130101)
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10232376 — Pipette travel limiting apparatus

US 10232376	Capaccio et al.
FUNDED BY	Department of Health and Human Services (HHS) Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA)
APPLICANT(S)	Christopher James Capaccio (Baltimore, Maryland); Peter Charles Crisman (Baltimore, Maryland); Richard Joseph Kowalski, Jr. (Leesburg, Virginia); Ryan Christopher Mahnke (Crownsville, Maryland)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Christopher James Capaccio (Baltimore, Maryland); Peter Charles Crisman (Baltimore, Maryland); Richard Joseph Kowalski, Jr. (Leesburg, Virginia); Ryan Christopher Mahnke (Crownsville, Maryland)
ABSTRACT	An apparatus for limiting pipette head travel with respect to a ground surface, and for limiting insertion of a pipette into a tube, has a top surface including at least one aperture. Each aperture selectively and concurrently accepts a corresponding pipette head of a pipette device therethrough. A bottom surface extends substantially parallel to the top surface and selectively contacts the ground surface. A plurality of side surfaces extends transversely between the top and bottom surfaces. The side surfaces each have a predetermined height correlated with a desired minimum approach distance of each pipette head toward the ground surface. The top, bottom, and side surfaces collectively enclose and define a spacer volume, at least partially through which each pipette corresponding to a pipette head extends. Methods of limiting pipette head travel with respect to a ground surface, and of limiting insertion of a pipette into a tube, are also provided.
FILED	Tuesday, July 12, 2016
APPL NO	15/207921
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 9/54 (20130101) Original (OR) Class B01L 2200/14 (20130101) B01L 2200/025 (20130101) B01L 2200/026 (20130101)
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10233162 — Electronically activated strained alkynes

US 10233162	Schomaker et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Jennifer M. Schomaker (Madison, Wisconsin); Eileen G. Burke (Somerville, Massachusetts)
ABSTRACT	Compounds of Formula I: wherein: R¹and R²are hydrogen or C₁to C₁₂linear or branched alkyl; R³is hydrogen, C₁to C₁₂linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R⁴is absent; and when X is nitrogen, R⁴is C₁to C₁₂linear or branched alkyl or nitrogen protecting groups. The compounds are useful as reagents in 1,3-cycloaddition reactions.
FILED	Thursday, January 18, 2018
APPL NO	15/873984
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 285/38 (20130101) C07D 291/02 (20130101) Original (OR) Class
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10233167 — 14-hydroxy-docosahexaenoic acid compounds

US 10233167	Serhan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Brigham And Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S)	Charles N. Serhan (Needham, Massachusetts); Rong Yang (Boston, Massachusetts)
ABSTRACT	The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
FILED	Monday, February 20, 2017
APPL NO	15/437211
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Fodder A23K 20/158 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 8/37 (20130101) A61K 8/365 (20130101) A61K 8/4973 (20130101) A61K 31/202 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 5/006 (20130101) A61Q 19/00 (20130101) A61Q 19/08 (20130101) Acyclic or Carbocyclic Compounds C07C 59/42 (20130101) C07C 59/58 (20130101) C07C 69/732 (20130101) Heterocyclic Compounds C07D 303/12 (20130101) C07D 303/38 (20130101) Original (OR) Class Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/55 (20151101)
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10233168 — 14-hydroxy-docosahexaenoic acid compounds

US 10233168	Serhan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Brigham And Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S)	Charles N. Serhan (Needham, Massachusetts); Rong Yang (Boston, Massachusetts)
ABSTRACT	The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
FILED	Monday, February 20, 2017
APPL NO	15/437217
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Fodder A23K 20/158 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 8/37 (20130101) A61K 8/365 (20130101) A61K 8/4973 (20130101) A61K 31/202 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 5/006 (20130101) A61Q 19/00 (20130101) A61Q 19/08 (20130101) Acyclic or Carbocyclic Compounds C07C 59/42 (20130101) C07C 59/58 (20130101) C07C 69/732 (20130101) Heterocyclic Compounds C07D 303/12 (20130101) C07D 303/38 (20130101) Original (OR) Class Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/55 (20151101)
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10233171 — Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders

US 10233171	Stockwell et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S)
INVENTOR(S)	Brent R. Stockwell (New York, New York); Scott J. Dixon (New York, New York); Rachid Skouta (New York, New York)
ABSTRACT	The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
FILED	Friday, February 24, 2017
APPL NO	15/442475
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/44 (20130101) A61K 31/245 (20130101) A61K 31/325 (20130101) A61K 31/351 (20130101) A61K 31/444 (20130101) A61K 31/495 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/4465 (20130101) A61K 31/4468 (20130101) A61K 31/5375 (20130101) A61K 45/06 (20130101) Acyclic or Carbocyclic Compounds C07C 69/78 (20130101) C07C 205/57 (20130101) C07C 205/58 (20130101) C07C 211/50 (20130101) C07C 225/22 (20130101) C07C 229/60 (20130101) C07C 233/54 (20130101) C07C 237/30 (20130101) C07C 255/58 (20130101) C07C 271/16 (20130101) C07C 271/24 (20130101) C07C 271/28 (20130101) C07C 2601/02 (20170501) C07C 2601/04 (20170501) C07C 2601/08 (20170501) C07C 2601/14 (20170501) C07C 2601/18 (20170501) C07C 2601/20 (20170501) C07C 2603/74 (20170501) Heterocyclic Compounds C07D 211/58 (20130101) C07D 213/36 (20130101) C07D 213/74 (20130101) C07D 213/80 (20130101) C07D 239/26 (20130101) C07D 239/42 (20130101) C07D 295/30 (20130101) C07D 295/088 (20130101) C07D 295/192 (20130101) C07D 309/14 (20130101) C07D 401/12 (20130101) Original (OR) Class
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10233192 — Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents

US 10233192	Nicolaou et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	WILLIAM MARSH RICE UNIVERSITY (Houston, Texas); BRISTOL-MYERS SQUIBB COMPANY (Princeton, New Jersey); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
ASSIGNEE(S)	WILLIAM MARSH RICE UNIVERSITY (Houston, Texas); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); BRISTOL-MYERS SQUIBB COMPANY (Princeton, New Jersey)
INVENTOR(S)	Kyriacos C. Nicolaou (Houston, Texas); Min Lu (Houston, Texas); Debashis Mandal (Houston, Texas); Sanjeev Gangwar (Foster City, California); Naidu S. Chowdari (Dublin, California); Yam B. Poudel (San Mateo, California)
ABSTRACT	In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
FILED	Tuesday, August 15, 2017
APPL NO	15/677959
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) A61K 47/6851 (20170801) Heterocyclic Compounds C07D 491/08 (20130101) Original (OR) Class
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10233194 — Pyrimidine compounds and pyrimido indole compounds and methods of use

US 10233194	Gangjee
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Duquesne University of the Holy Spirit (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	Duquesne Unversity of the Holy Spirit (Pittsburgh, Pennsylvania)
INVENTOR(S)	Aleem Gangjee (Allison Park, Pennsylvania)
ABSTRACT	The present invention discloses a compound comprising the formula: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the S is replaced by CH₂, and optionally comprising a pharmaceutically acceptable salt, hydrate, or solvate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt, hydrate, or solvate thereof.
FILED	Wednesday, April 05, 2017
APPL NO	15/479752
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/343 (20130101) A61K 31/505 (20130101) A61K 31/4709 (20130101) Heterocyclic Compounds C07D 239/48 (20130101) C07D 403/02 (20130101) C07D 405/02 (20130101) C07D 487/04 (20130101) C07D 495/04 (20130101) Original (OR) Class
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10233201 — Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury

US 10233201	Hukriede et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburg Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Neil Hukriede (Allison Park, Pennsylvania); Billy W. Day (Pittsburgh, Pennsylvania); Lee A. McDermott (Pittsburgh, Pennsylvania)
ABSTRACT	Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
FILED	Tuesday, May 30, 2017
APPL NO	15/607826
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 317/22 (20130101) C07C 317/44 (20130101) C07C 321/28 (20130101) C07C 323/16 (20130101) C07C 323/20 (20130101) C07C 323/47 (20130101) C07C 323/52 (20130101) C07C 323/60 (20130101) C07C 323/62 (20130101) Heterocyclic Compounds C07D 213/75 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3229 (20130101) C07F 9/4841 (20130101) Original (OR) Class C07F 9/5325 (20130101)
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10233209 — Inhibitors of the farnesoid x receptor and uses in medicine

US 10233209	Gonzalez et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS) Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	The United States of America, As represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Frank J. Gonzalez (Bethesda, Maryland); Changtao Jiang (Beijing, China PRC); Cen Xie (Rockville, Maryland); Andrew D. Patterson (State College, Pennsylvania); Fei Li (Rockville, Maryland); James B. Mitchell (Damascus, Maryland); Shantu Amin (Union City, New Jersey); Dhimant Desai (Mechanicsburg, Pennsylvania)
ABSTRACT	Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R¹, R², R⁴, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal.
FILED	Tuesday, December 06, 2016
APPL NO	15/371032
ART UNIT	1621 — Organic Chemistry
CURRENT CPC	Steroids C07J 9/005 (20130101) C07J 31/006 (20130101) C07J 41/0055 (20130101) C07J 41/0061 (20130101) Original (OR) Class C07J 41/0066 (20130101)
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10233216 — Compositions and methods for suppression of inhibitor formation against coagulation factors in hemophilia patients

US 10233216	Herzog et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadephia, Pennsylvania); UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); University of Florida Research Foundation, Inc. (Gainesville, Florida)
INVENTOR(S)	Roland W. Herzog (Gainesville, Florida); Henry Daniell (Media, Pennsylvania)
ABSTRACT	Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is often complicated by pathogenic antibody responses, including antibodies that neutralize the therapeutic protein or that predispose to potentially life-threatening anaphylactic reactions by formation of IgE. Using murine and canine hemophilia as a model, we have developed a prophylactic protocol against such responses that is non-invasive and does not include immune suppression or genetic manipulation of the patient's cells. Oral delivery of a coagulation factor expressed in chloroplasts, bioencapsulated in plant cells, effectively blocked formation of inhibitory antibodies in protein replacement therapy. Inhibitor titers were mostly undetectable and up to 100-fold lower in treated subjects when compared to controls. Moreover, this treatment eliminated fatal anaphylactic reactions that occurred after four to six exposures to intravenous coagulation factor protein. Finally, the method can effectively be used to reverse or reduce undesirable pre-existing inhibitor titers.
FILED	Monday, May 16, 2016
APPL NO	15/037045
ART UNIT	1675 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 36/00 (20130101) A61K 38/36 (20130101) A61K 38/37 (20130101) A61K 38/45 (20130101) A61K 38/47 (20130101) Peptides C07K 14/28 (20130101) Original (OR) Class C07K 14/755 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8214 (20130101) C12N 15/8257 (20130101) Enzymes C12Y 204/00 (20130101) C12Y 302/0102 (20130101) C12Y 302/01022 (20130101) Technologies for Adaptation to Climate Change Y02A 50/471 (20180101)
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10233219 — Methods and systems for designing and/or characterizing soluble lipidated ligand agents

US 10233219	Cohen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Tufts Medical Center (Boston, Massachusetts); Trustees of Tufts College (Medford, Massachusetts); On Target Therapeutics LLC (Wellesley, Massachusetts)
ASSIGNEE(S)	Tufts Medical Center (Boston, Massachusetts); Trustees of Tufts College (Medford, Massachusetts); On Target Therapeutics LLC (Wellesley, Massachusetts)
INVENTOR(S)	Charles Cohen (Weston, Massachusetts); Krishna Kumar (Cambridge, Massachusetts); Jamie Raudensky Doyle (Newton, Massachusetts); Alan S. Kopin (Wellesley, Massachusetts)
ABSTRACT	The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.
FILED	Thursday, March 13, 2014
APPL NO	14/783489
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/543 (20170801) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/4703 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 33/5023 (20130101) G01N 2405/00 (20130101) G01N 2440/10 (20130101)
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10233224 — Nucleic acids encoding a fusion protein useful for multi-level specific targeting of cancer cells

US 10233224	Debinski et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Wake Forest University Health Sciences (Winston-Salem, North Carolina)
ASSIGNEE(S)	WAKE FOREST UNIVERSITY HEALTH SCIENCES (Winston-Salem, North Carolina)
INVENTOR(S)	Waldemar Debinski (Winston-Salem, North Carolina); Hetal Pandya (Winston-Salem, North Carolina); Denise Gibo (Winston-Salem, North Carolina)
ABSTRACT	A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.
FILED	Tuesday, September 05, 2017
APPL NO	15/695392
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/642 (20170801) Peptides C07K 14/005 (20130101) C07K 14/21 (20130101) C07K 14/34 (20130101) C07K 14/195 (20130101) C07K 14/5437 (20130101) Original (OR) Class C07K 19/00 (20130101) C07K 2319/01 (20130101) C07K 2319/09 (20130101) C07K 2319/74 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/532 (20130101) G01N 33/5008 (20130101) G01N 33/5091 (20130101) G01N 33/6869 (20130101) G01N 2333/025 (20130101) G01N 2333/195 (20130101) G01N 2333/5437 (20130101)
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10233233 — Lipopolysaccharide-targeted peptide mimic vaccine against Q fever

US 10233233	Zhang
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Guoquan Zhang (Columbia, Missouri)
ASSIGNEE(S)	The Curators of the University of Missouri (Columbia, Missouri)
INVENTOR(S)	Guoquan Zhang (Columbia, Missouri)
ABSTRACT	A vaccine and method of vaccination for conferring immunity to Q fever is described. The vaccine comprises a polypeptide with a sequence of SLTWHKHELHRK (SEQ ID NO: 7) (m1E41920) or SPPWHKHELHRK (SEQ ID NO: 8) (m1E44), or at least 90% identity to m1E41920 or m1E44. Constructs are also provided for use in vaccination and treatment of Q fever. A method to identify and generate new vaccines to prevent diseases caused by intracellular Gram-negative bacteria is also described.
FILED	Tuesday, June 28, 2016
APPL NO	15/195586
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 7/08 (20130101) C07K 16/126 (20130101) C07K 16/1203 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101)
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10233235 — Modulating the alternative complement pathway

US 10233235	Thurman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)	The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
INVENTOR(S)	Joshua M. Thurman (Greenwood Village, Colorado); V. Michael Holers (Denver, Colorado)
ABSTRACT	Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the alternative complement pathway, and methods of identifying factor H-binding proteins.
FILED	Monday, December 15, 2014
APPL NO	14/571102
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/177 (20130101) A61K 38/1709 (20130101) Peptides C07K 14/4721 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Enzymes C12Y 402/01002 (20130101)
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10233240 — Methods for treating cholestatic liver fibrosis

US 10233240	Kisseleva et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Tatiana Kisseleva (La Jolla, California); David Brenner (La Jolla, California)
ABSTRACT	Provided are methods of treating fibrotic conditions in a subject by the identification of specific subsets of fibrogenic myofibroblasts, such as portal fibroblasts expressing mesothelin, and diagnostic methods useful for determining fibrosis, and the prognosis of fibrosis.
FILED	Thursday, May 15, 2014
APPL NO	14/279245
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 47/48 (20130101) Peptides C07K 16/28 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1138 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 2800/085 (20130101)
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10233252 — pH-dependent antibodies targeting the transferrin receptor and methods of use thereof to deliver a therapeutic agent

US 10233252	Shusta et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Eric V. Shusta (Madison, Wisconsin); Benjamin J. Tillotson (Thousand Oaks, California)
ABSTRACT	A pH-dependent antibody that binds an antigen with high affinity at a first pH and rapidly dissociates at a second pH, wherein the antigen is a transferrin receptor (TfR), wherein the association at the second pH/the first pH is less than 20%, and wherein the pH-dependent antibody comprises at least two consecutive histidine residues at a single complementarity determining region (CDR) is disclosed.
FILED	Thursday, December 15, 2016
APPL NO	15/379597
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/2881 (20130101) Original (OR) Class C07K 2317/77 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/01 (20130101)
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10233415 — Microfluidics cell culture device

US 10233415	Mathur et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Anurag Mathur (Berkeley, California); Peter Loskill (Berkeley, California); Luke P. Lee (Orinda, California); Kevin E. Healy (Moraga, California); Soongweon Hong (Berkeley, California)
ABSTRACT	The present disclosure provides a microfluidics device for culturing cells, such as cardiomyocytes or cardiomyocyte progenitors; and methods of culturing cells using the device. The device and culturing methods find use in drug screening methods, for methods of evaluating a drug under development, and for methods of predicting patient response to a given treatment regimen, which methods are also provided.
FILED	Monday, July 21, 2014
APPL NO	14/906492
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 33/12 (20130101) C12M 41/46 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/4836 (20130101)
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10233420 — Methods of recellularizing a tissue or organ for improved transplantability

US 10233420	Taylor et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Doris Taylor (St. Paul, Minnesota); Stefan M. Kren (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Doris Taylor (St. Paul, Minnesota); Stefan M. Kren (Minneapolis, Minnesota)
ABSTRACT	Described herein are methods of recellularizing an organ or tissue matrix.
FILED	Thursday, September 01, 2011
APPL NO	13/820079
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3604 (20130101) A61L 27/3808 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class
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10233425 — CD137 enrichment for efficient tumor infiltrating lymphocyte selection

US 10233425	Powell, Jr.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Daniel J. Powell, Jr. (Bala Cynwyd, Pennsylvania)
ABSTRACT	The invention includes compositions and methods to rapidly isolate and culture cells that are potent for use in adoptive immunotherapy. In one embodiment, the isolated cells of the invention are tumor infiltrating lymphocytes (TIL) that express CD137 (also known as 4-1BB and TNFSFR9).
FILED	Tuesday, September 16, 2014
APPL NO	14/917214
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) Original (OR) Class C12N 5/0646 (20130101)
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10233428 — Restrictive inverted terminal repeats for viral vectors

US 10233428	Hewitt et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S)	Curtis Hewitt (Austin, Texas); Richard Jude Samulski (Chapel Hill, North Carolina)
ABSTRACT	This invention relates to modified parvovirus inverted terminal repeats (ITRs) that do not functionally interact with wild-type large Rep proteins, synthetic Rep proteins that functionally interact with the modified ITRs, and methods of using the same for delivery of nucleic acids to a cell or a subject. The modifications provide a novel Rep-ITR interaction that limits vector mobilization, increasing the safety of viral vectors.
FILED	Monday, October 26, 2015
APPL NO	14/922935
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/8645 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14162 (20130101) C12N 2750/14322 (20130101) C12N 2750/14352 (20130101) C12N 2820/60 (20130101)
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10233438 — Engineered primate L-methioninase for therapeutic purposes

US 10233438	Georgiou et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	George Georgiou (Austin, Texas); Everett Stone (Austin, Texas); Wei-Cheng Lu (Austin, Texas)
ABSTRACT	Methods and compositions relating to the engineering of an improved protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
FILED	Monday, March 06, 2017
APPL NO	15/451349
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 38/51 (20130101) A61K 38/51 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/20 (20130101) C12N 5/0601 (20130101) C12N 9/88 (20130101) Original (OR) Class C12N 15/70 (20130101) C12N 15/74 (20130101) C12N 15/79 (20130101) Enzymes C12Y 404/01001 (20130101)
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10233450 — Methods and compositions for the specific inhibition of gene expression by double-stranded RNA

US 10233450	Rossi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	CITY OF HOPE (Duarte, California); INTEGRATED DNA TECHNOLOGIES, INC. (Coralville, Iowa)
ASSIGNEE(S)	CITY OF HOPE (Duarte, California); INTEGRATED DNA TECHNOLOGIES, INC. (Coralville, Iowa)
INVENTOR(S)	John J. Rossi (Azusa, California); Mark A. Behlke (Coralville, Iowa); Dongho Kim (Beverly Hills, California)
ABSTRACT	The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded RNA (“dsRNA”), and methods for preparing them, that are capable of reducing the expression of target genes in eukaryotic cells. The dsRNA has a first oligonucleotide sequence that is between 25 and about 30 nucleotides in length and a second oligonucleotide sequence that anneals to the first sequence under biological conditions. In addition, a region of one of the sequences of the dsRNA having a sequence length of at least 19 nucleotides is sufficiently complementary to a nucleotide sequence of the RNA produced from the target gene to trigger the destruction of the target RNA by the RNAi machinery.
FILED	Thursday, December 21, 2017
APPL NO	15/849887
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/33 (20130101) C12N 2310/53 (20130101) C12N 2310/533 (20130101) C12N 2320/35 (20130101) C12N 2320/51 (20130101)
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10233452 — Compositions and methods for increasing erythropoietin (EPO) production

US 10233452	Kaelin, Jr. et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	ALNYLAM PHARMACEUTICALS, INC. (Cambridge, Massachusetts); DANA-FARBER CANCER INSTITUTE (Boston, Massachusetts)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Alnylam Pharmaceuticals, Inc. (Cambridge, Massachusetts)
INVENTOR(S)	William G. Kaelin, Jr. (Boston, Massachusetts); Victor Kotelianski (Newton, Massachusetts); William Querbes (Boston, Massachusetts); Brian Bettencourt (Groton, Massachusetts)
ABSTRACT	The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting one or more EGLN genes, EGLN1, EGLN2 and/or EGLN3 and methods of using such dsRNA compositions to inhibit expression of these genes.
FILED	Monday, October 19, 2015
APPL NO	14/886550
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/321 (20130101) C12N 2310/335 (20130101) C12N 2310/344 (20130101) C12N 2310/3521 (20130101) C12N 2320/31 (20130101) Enzymes C12Y 114/11002 (20130101)
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10233463 — Neurotensin-induced tumor formation is regulated by micro RNA 133A-aftiphilin-dependent receptor recycling

US 10233463	Pothoulakis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Charalabos Pothoulakis (Los Angeles, California); Dimitrios Iliopoulos (Los Angeles, California); Ka Man Law (Los Angeles, California)
ABSTRACT	This application discloses methods of treating, preventing, and diagnosing colorectal cancer and IBD in a subject comprising administering an effective dose of antisense miR-133α or AFTPH to the subject or detecting expression levels of miR-133α and AFTPH.
FILED	Friday, September 30, 2016
APPL NO	15/282694
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/1709 (20130101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 15/1135 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/113 (20130101) C12N 2310/141 (20130101) C12N 2310/3231 (20130101) C12N 2320/30 (20130101) C12N 2740/15043 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101)
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10233490 — Methods for assembling and reading nucleic acid sequences from mixed populations

US 10233490	Stapleton et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	METABIOTECH CORPORATION (Sunnyvale, California)
ASSIGNEE(S)	Metabiotech Corporation (Sunnyvale, California)
INVENTOR(S)	James A. Stapleton (Eugene, Oregon); Timothy Whitehead (East Grand Rapids, Michigan)
ABSTRACT	The disclosure relates to methods for obtaining nucleic acid sequence information by constructing a nucleic acid library and reconstructing longer nucleic acid sequences by assembling a series of shorter nucleic acid sequences.
FILED	Friday, November 20, 2015
APPL NO	14/947988
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 2521/501 (20130101) C12Q 2521/501 (20130101) C12Q 2525/155 (20130101) C12Q 2525/155 (20130101) C12Q 2525/191 (20130101) C12Q 2525/191 (20130101) C12Q 2531/125 (20130101) C12Q 2531/125 (20130101) C12Q 2535/122 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101)
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10233498 — Therapeutic agent for emphysema and COPD

US 10233498	Spira et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts); THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver, Canada)
ASSIGNEE(S)	TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts); THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver, Canada)
INVENTOR(S)	Avrum Elliott Spira (Newton, Massachusetts); Marc Lenburg (Brookline, Massachusetts); Joshua Campbell (Quincy, Massachusetts); Julie Erin Zeskind Gil (Brookline, Massachusetts); Dimitri Petchkovski (Vancouver, Canada); James Cameron Hogg (Vancouver, Canada)
ABSTRACT	The invention described herein relates to methods of treating emphysema and COPD with a GHK tripeptide. The invention further relates to methods of determining the state of the lungs using biomarkers described herein.
FILED	Thursday, January 19, 2017
APPL NO	15/410165
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 38/06 (20130101) A61K 45/06 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 15/009 (20130101) A61M 16/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6884 (20130101) G01N 33/54306 (20130101) G01N 33/56966 (20130101) G01N 2500/04 (20130101) G01N 2800/60 (20130101) G01N 2800/122 (20130101)
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10233504 — Methods and compositions for isothermal amplification and detection of mycoplasma pneumoniae

US 10233504	Winchell et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Washington, District of Columbia); P3S Corporation (San Antonio, Texas)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); P3S Corporation (San Antonio, Texas)
INVENTOR(S)	Jonas M. Winchell (Lilburn, Georgia); Brianna Petrone (Durham, North Carolina); Maureen H. Diaz (Atlanta, Georgia); Bernard J. Wolff (Roswell, Georgia)
ABSTRACT	Disclosed herein are methods and compositions (e.g., oligonucleotide primers) for isothermal amplification and detection of M. pneumoniae nucleic acids in a sample. In some embodiments, the methods include contacting a sample with a set of LAMP primers specific for a M. pneumoniae CARDS toxin-encoding nucleic acid under conditions sufficient to produce an M. pneumoniae nucleic acid amplification product and detecting the resulting M. pneumoniae amplification product. Kits including sets of LAMP primers for detection of M. pneumoniae CARDS toxin nucleic acids are also provided herein.
FILED	Friday, February 12, 2016
APPL NO	15/043194
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6844 (20130101) C12Q 2525/301 (20130101) C12Q 2531/119 (20130101)
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10234423 — Hybrid ion mobility spectrometer

US 10234423	Clemmer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Indiana University Research and Technology Corporation (Indianapolis, Indiana)
ASSIGNEE(S)	Indiana University Research and Technology Corporation (Indianapolis, Indiana)
INVENTOR(S)	David E. Clemmer (Bloomington, Indiana); Michael A. Ewing (Bloomington, Indiana)
ABSTRACT	A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and at least one ion steering channel controllable to selectively pass ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to selectively pass ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube. The single-pass drift tube separates in time ions traveling therethrough according to a first function of ion mobility, and the multiple-pass drift tube separates in time ions traveling one or more times therethrough according to the first or a second function of ion mobility.
FILED	Friday, May 26, 2017
APPL NO	15/606478
ART UNIT	2881 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/622 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) H01J 49/26 (20130101) H01J 49/46 (20130101) H01J 49/443 (20130101)
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10234459 — Sensors and assays for ubiquitin or ubiquitin-like proteins

US 10234459	Cohen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Colorado State University Research Foundation (Fort Collins, Colorado)
ASSIGNEE(S)	COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado)
INVENTOR(S)	Robert E. Cohen (Fort Collins, Colorado); Yun-Seok Choi (Fort Collins, Colorado)
ABSTRACT	The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
FILED	Friday, May 11, 2018
APPL NO	15/977727
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/47 (20130101) C07K 14/435 (20130101) C07K 2319/00 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) Enzymes C12Y 304/19012 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) Original (OR) Class G01N 33/6872 (20130101)
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10234465 — BCL6 expression in eutopic endometrium as a marker for endometriosis and subfertility

US 10234465	Young et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); Greenville Health System (Greenville, South Carolina)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); Greenville Health Systems (Greenville, South Carolina)
INVENTOR(S)	Steven Young (Durham, North Carolina); Bruce Lessey (Greenville, South Carolina)
ABSTRACT	Methods for identifying subjects as candidates for embryo implantation are provided. In some embodiments, the methods include providing a sample of endometrium isolated from a subject during the second half of the subject's menstrual cycle and determining whether the subject is a candidate based on the expression of BCL6 in the sample. Also provided are methods for identifying an increased risk for implantation failure subsequent to in vitro fertilization (IVF) and/or frozen embryo transfer (FET), methods for detecting endometrial receptivity, methods for facilitating diagnoses of infertility, methods for increasing the likelihood of embryo implantation, methods for detecting the presence of endometriosis, and methods for managing treatment of subjects with potential endometriosis, subfertility, or both.
FILED	Thursday, March 19, 2015
APPL NO	15/126857
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/689 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/364 (20130101) G01N 2800/367 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) G06F 19/24 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) Technologies for Adaptation to Climate Change Y02A 90/26 (20180101)
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10234466 — Kits and methods for determining physiologic level(s) and/or range(s) of hemoglobin and/or disease state

US 10234466	Lam et al.
FUNDED BY	Department of Health and Human Services (HHS) Centers for Disease Control and Prevention (CDC)
APPLICANT(S)	EMORY UNIVERSITY (Atlanta, Georgia); THE UNITED STATES OF AMERICA REPRESENTED BY THE SECT OF THE DEPT OF HEALTH AND HUMAN SCVS/CENTERS FOR DISEASE CONTROL (Washington, District of Columbia); CHILDREN'S HEALTHCARE OF ATLANTA, INC. (Atlanta, Georgia); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S)	Wilbur A. Lam (Decatur, Georgia); Morgan Byrd (Memphis, Tennessee); Erika Tyburski (Decatur, Georgia); Michael L. McKinnon (Decatur, Georgia); Siobhan O'Connor (Decatur, Georgia); Nathan A. Hotaling (Ocala, Florida)
ABSTRACT	Diagnostic kits and methods configured to rapidly and non-invasively determine physiologic levels of hemoglobin. A diagnostic kit may include a chamber pre-filled with an indicator, the indicator solution including a tetramethylbenzidine (TMB) solution, the indicator being configured to change color; a collection device configured to collect a test sample from a subject. The kit may also include a hemoglobin physiologic level identifier legend, the legend indicating 1) at least one color of the indicator and 2) a physiologic level and/or range of the hemoglobin and/or disease state associated with the color.
FILED	Friday, March 15, 2013
APPL NO	14/411420
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/157 (20130101) A61B 5/15105 (20130101) A61B 5/150022 (20130101) A61B 5/150305 (20130101) A61B 5/150343 (20130101) A61B 5/150351 (20130101) A61B 5/150358 (20130101) A61B 5/150412 (20130101) A61B 5/150503 (20130101) A61B 5/150755 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/721 (20130101) Original (OR) Class G01N 2800/22 (20130101)
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10234573 — Digital probe

US 10234573	Nagarkar et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Radiation Monitoring Devices, Inc. (Watertown, Massachusetts)
ASSIGNEE(S)	RADIATION MONITORING DEVICES, INC. (Watertown, Massachusetts)
INVENTOR(S)	Vivek V. Nagarkar (Weston, Massachusetts); Bipin Singh (Chelmsford, Massachusetts); Hamid Sabet (Watertown, Massachusetts); Haris Kudrolli (Watertown, Massachusetts)
ABSTRACT	A dual-mode, hand-held, digital probe, designed to rapidly localize tissues of interest through gamma detection, and provide high-resolution, real-time images of the suspect area by sensing beta radiation is presented. A position-sensitive solid-state photomultiplier is optically bonded with a hybrid scintillator including a thin Crystalline Microcolumnar Structure (CMS) CsI:T1 scintillator, vapor-deposited directly onto a monolithic (polycrystalline) LYSO scintillator.
FILED	Tuesday, August 15, 2017
APPL NO	15/677629
ART UNIT	2884 — Optics
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/02 (20130101) C23C 14/18 (20130101) Measurement of Nuclear or X-radiation G01T 1/2018 (20130101) Original (OR) Class G01T 1/2023 (20130101)
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10235600 — System and method for structured low-rank matrix factorization: optimality, algorithm, and applications to image processing

US 10235600	Vidal et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Deafness and Other Communication Disorders (NIDCD) National Science Foundation (NSF)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Rene Vidal (Fulton, Maryland); Benjamin Haeffele (Oakland, California); Eric D. Young (Baltimore, Maryland)
ABSTRACT	The present invention provides a system and method for structured low-rank matrix factorization of data. The system and method involve solving an optimization problem that is not convex, but theoretical results should that a rank-deficient local minimum gives a global minimum. The system and method also involve an optimization strategy that is highly parallelizable and can be performed using a highly reduced set of variables. The present invention can be used for many large scale problems, with examples in biomedical video segmentation and hyperspectral compressed recovery.
FILED	Wednesday, June 22, 2016
APPL NO	15/189270
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6247 (20130101) Original (OR) Class G06K 2009/4695 (20130101)
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10235755 — High-throughput adaptive sampling for whole-slide histopathology image analysis

US 10235755	Madabhushi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Anant Madabhushi (Shaker Heights, Ohio); Angel Alfonso Cruz Roa (Villavicencio, Colombia); Fabio Gonzalez (Bogota, Colombia)
ABSTRACT	Methods, apparatus, and other embodiments associated with classifying a region of tissue represented in a digitized whole slide image (WSI) using iterative gradient-based quasi-Monte Carlo (QMC) sampling. One example apparatus includes an image acquisition circuit that acquires a WSI of a region of tissue demonstrating cancerous pathology, an adaptive sampling circuit that selects a subset of tiles from the WSI using an iterative QMC Sobol sequence sampling approach, an invasiveness circuit that determines a probability of a presence of invasive pathology in a member of the subset of tiles, a probability map circuit that generates an invasiveness probability map based on the probability, a probability gradient circuit that generates a gradient image based on the invasiveness probability map, and a classification circuit that classifies the region of tissue based on the probability map. A prognosis or treatment plan may be provided based on the classification of the WSI.
FILED	Friday, June 29, 2018
APPL NO	16/023361
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 10/0041 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/627 (20130101) G06K 9/4604 (20130101) G06K 9/4628 (20130101) G06K 9/4642 (20130101) G06K 9/6269 (20130101) G06K 9/6277 (20130101) G06K 2209/051 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10024 (20130101) G06T 2207/10056 (20130101) G06T 2207/20021 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 50/20 (20180101)
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10236170 — Methods and devices for generating double emulsions

US 10236170	Chiu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	University of Washington through its Center for Commercialization (Seattle, Washington)
ASSIGNEE(S)	University of Washington through its Center for Commercialization (Seattle, Washington)
INVENTOR(S)	Daniel T. Chiu (Seattle, Washington); Dingsheng Liu (Seattle, Washington)
ABSTRACT	The present disclosure describes devices and methods capable of generating multi¬phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.
FILED	Thursday, March 09, 2017
APPL NO	15/454558
ART UNIT	2881 — Optics
CURRENT CPC	Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/03 (20130101) B05B 5/025 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/165 (20130101) Original (OR) Class H01J 49/0445 (20130101)
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10237663 — Devices and methods for hearing

US 10237663	Puria et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S)	EarLens Corporation (Menlo Park, California)
ASSIGNEE(S)	EarLens Corporation (Menlo Park, California)
INVENTOR(S)	Sunil Puria (Boston, Massachusetts); Micha Rosen (Tzur Hadassah, Israel); Jonathan P. Fay (Dexter, Michigan); Paul Rucker (San Francisco, California); James Stone (Saratoga, California)
ABSTRACT	A device to transmit an audio signal to a user comprises a transducer and a support. The support is configured for placement on the eardrum to drive the eardrum. The transducer is coupled to the support at a first location to decrease occlusion and a second location to drive the eardrum. The transducer may comprise one or more of an electromagnetic balanced armature transducer, a piezoelectric transducer, a magnetostrictive transducer, a photostrictive transducer, or a coil and magnet. The device may find use with open canal hearing aids.
FILED	Friday, September 15, 2017
APPL NO	15/706236
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 11/02 (20130101) Original (OR) Class H04R 17/00 (20130101) H04R 23/008 (20130101) H04R 25/02 (20130101) H04R 25/65 (20130101) H04R 25/554 (20130101) H04R 25/606 (20130101) H04R 25/652 (20130101) H04R 2225/025 (20130101) H04R 2460/09 (20130101) H04R 2460/13 (20130101)
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Department of Defense (DOD)

10231626 — Imaging system and method for fluorescence guided surgery

US 10231626	Steinbach et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Paul Steinbach (San Diego, California); Quyen T. Nguyen (La Jolla, California); Roger Y. Tsien (La Jolla, California)
ABSTRACT	Imaging systems for fluorescence guided surgery are provided. An imaging system comprises a light source unit for providing one or more illumination and excitation lights to a target, a detection unit for detecting reflectance and fluorescence from the target, an optical train for directing the one or more illumination and excitation lights from the light source unit to the target and for directing the reflectance and fluorescence from the target to the detection unit, and a control unit for controlling the light source unit and the detection unit. Imaging methods for fluorescence guided surgery are also provided.
FILED	Monday, March 17, 2014
APPL NO	14/216704
ART UNIT	3737 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/0062 (20130101) A61B 5/0071 (20130101) Original (OR) Class A61B 5/0077 (20130101)
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10231651 — Gait authentication system and method thereof

US 10231651	Deng et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	BAE Systems Information And Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Yunbin Deng (Westford, Massachusetts); Yu Zhong (Winchester, Massachusetts)
ABSTRACT	A gait authentication system and method is provided. The system includes a mobile computing device configured to be carried by a person while moving with a unique gait. A first sensor (e.g. an accelerometer) is carried by the mobile computing device and generates a first signal. A second sensor (e.g. a gyroscope) is carried by the mobile computing device and generates a second signal. A gait dynamics logic implements an identity vector (i-vector) approach to learn feature representations from a sequence of arbitrary feature vectors carried by the first and second signals. In the method for real time gait authentication, the computing of invariant gait representations are robust to sensor placement while preserving highly discriminative temporal and spatial gait dynamics and context.
FILED	Tuesday, August 25, 2015
APPL NO	14/835258
ART UNIT	2685 — Selective Communication
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/112 (20130101) A61B 5/117 (20130101) Original (OR) Class A61B 5/6898 (20130101) A61B 2562/0219 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00348 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/083 (20130101) H04L 63/0861 (20130101) Wireless Communication Networks H04W 12/06 (20130101)
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10231706 — Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

US 10231706	Chen et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Zhongping Chen (Irvine, California); Wenjuan Qi (Irvine, California); Rui Li (Irvine, California)
ABSTRACT	An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PRARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the returned ultrasound signal and the measured frequency dependence of the returned PR-ARF-OCE optical coherence elastographic signal to quantitatively measure the mechanical properties of the identified tissues with both spectral and spatial resolution using enhanced materials response at mechanically resonant frequencies.
FILED	Friday, March 14, 2014
APPL NO	14/213904
ART UNIT	3737 — Audio Signals
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0035 (20130101) A61B 5/0066 (20130101) A61B 5/02007 (20130101) A61B 8/12 (20130101) A61B 8/445 (20130101) A61B 8/485 (20130101) Original (OR) Class A61B 8/4416 (20130101) A61B 8/5261 (20130101)
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10231707 — Ultrasound waveform tomography with wave-energy-based preconditioning

US 10231707	Huang et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Congressionally Directed Medical Research Programs (CDMRP) Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Lianjie Huang (Los Alamos, New Mexico); Zhigang Zhang (Los Alamos, New Mexico)
ABSTRACT	Synthetic-aperture ultrasound tomography systems and methods using scanning arrays and algorithms configured to simultaneously acquire ultrasound transmission and reflection data, and process the data using ultrasound waveform tomography with a wave-energy-based preconditioning method for improved ultrasound tomography imaging.
FILED	Thursday, July 24, 2014
APPL NO	14/339759
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0073 (20130101) A61B 5/7275 (20130101) A61B 8/13 (20130101) A61B 8/14 (20130101) A61B 8/15 (20130101) A61B 8/085 (20130101) A61B 8/145 (20130101) A61B 8/406 (20130101) A61B 8/483 (20130101) A61B 8/0825 (20130101) A61B 8/4477 (20130101) A61B 8/4488 (20130101) A61B 8/4494 (20130101) A61B 8/5207 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/8915 (20130101) G01S 15/8929 (20130101) G01S 15/8997 (20130101) Image Data Processing or Generation, in General G06T 5/001 (20130101) G06T 11/005 (20130101)
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10231820 — Fabrication of vascularized tissue using microfabricated two-dimensional molds

US 10231820	Vacanti et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Joseph P. Vacanti (Boston, Massachusetts); Young-Moon M. Shin (Somerville, Massachusetts); Jennifer Ogilvie (San Francisco, California); Alexander Sevy (Houston, Texas); Tomoyuki Maemura (Boston, Massachusetts); Osamu Ishii (Arlington, Massachusetts); Mohammad R. Kaazempur-Mofrad (Cambridge, Massachusetts); Jeffrey T. Borenstein (Holliston, Massachusetts); Kevin R. King (Western Springs, Illinois); Chiao-Chun Wang (Baltimore, Maryland); Eli Weinberg (Needham, Massachusetts)
ABSTRACT	Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.
FILED	Thursday, November 17, 2016
APPL NO	15/354865
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/062 (20130101) Original (OR) Class A61F 2240/004 (20130101) A61F 2240/005 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/58 (20130101) A61L 27/3604 (20130101) A61L 27/3804 (20130101) A61L 27/3808 (20130101) A61L 27/3891 (20130101) A61L 27/3895 (20130101) A61L 2300/64 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/06 (20130101) C12M 23/30 (20130101) C12M 25/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0697 (20130101) C12N 2533/12 (20130101) C12N 2533/30 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49826 (20150115)
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10231859 — Brace system

US 10231859	Thorne et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Boston Dynamics, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	Boston Dynamics, Inc. (Waltham, Massachusetts)
INVENTOR(S)	Christopher Everett Thorne (Mountain View, California); Steven D. Potter (Mountain View, California); Michael Patrick Murphy (Mountain View, California)
ABSTRACT	The present disclosure provides a brace system including an upper portion and a lower portion. The brace system may also include a first pulley rotatably coupling the upper portion to a first intermediate link positioned between the upper portion and the lower portion. The brace system may also include a second pulley rotatably coupling the first intermediate link to a second intermediate link positioned between the upper portion and the lower portion. The brace system may also include a third pulley rotatably coupling the second intermediate link to the lower portion. Further, the brace system may include at least one tension-bearing element substantially encircling each of the first pulley, the second pulley, and the third pulley.
FILED	Thursday, May 01, 2014
APPL NO	14/266989
ART UNIT	3785 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/0102 (20130101) Original (OR) Class Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 3/00 (20130101)
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10232090 — Electrophoretically deposited strontium fluoride nanoparticle/polymer coatings for medical implants

US 10232090	Furman et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	Southwest Research Institute (San Antonio, Texas)
ASSIGNEE(S)	SOUTHWEST RESEARCH INSTITUTE (San Antonio, Texas)
INVENTOR(S)	Benjamin R. Furman (San Antonio, Texas); Stephen T. Wellinghoff (San Antonio, Texas)
ABSTRACT	The present disclosure provides for co-electrophoretic deposition (co-EPD) of organo-functionalized strontium fluoride nanoparticles (SrF₂) with a hydrophobic polymer in the presence of non-aqueous aprotic solvents. The co-EPD procedure can be employed to form a coating or self-supporting film for application to a metal implant.
FILED	Friday, August 23, 2013
APPL NO	13/974814
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 33/16 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/10 (20130101) A61L 31/022 (20130101) A61L 31/088 (20130101) Original (OR) Class A61L 31/128 (20130101) A61L 2300/102 (20130101) A61L 2300/606 (20130101) A61L 2420/02 (20130101) A61L 2420/04 (20130101) A61L 2420/06 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/00 (20130101) C25D 13/02 (20130101) C25D 13/04 (20130101) C25D 13/06 (20130101)
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10232142 — Conduit guiding tip

US 10232142	Franklin
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	Prytime Medical Devices, Inc. (Boerne, Texas)
ASSIGNEE(S)	Prytime Medical Devices, Inc. (Boerne, Texas)
INVENTOR(S)	Curtis J. Franklin (Lakewood, Colorado)
ABSTRACT	A catheter tip for guiding the catheter through a patient's blood vessels and keeping the catheter in large vessels and preventing entry into smaller branch vessels.
FILED	Wednesday, June 10, 2015
APPL NO	15/306540
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/01 (20130101) A61M 25/0068 (20130101) Original (OR) Class A61M 25/0074 (20130101) A61M 2025/0081 (20130101) A61M 2025/0096 (20130101)
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10232371 — Microfluidic devices and methods for cell processing

US 10232371	Collins
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	John Collins (Irvine, California)
ASSIGNEE(S)	Biopico Systems Inc (Irvine, California)
INVENTOR(S)	John Collins (Irvine, California)
ABSTRACT	Microfluidic devices and methods that use cells such as cancer cells, stem cells, blood cells for preprocessing, sorting for various biodiagnostics or therapeutical applications are described. Microfluidics electrical sensing such as measurement of field potential or current and phenomena such as immiscible fluidics, inertial fluidics are used as the basis for cell and molecular processing (e.g., characterizing, sorting, isolation, processing, amplification.) of different particles, chemical compositions or biospecies (e.g., different cells, cells containing different substances, different particles, different biochemical compositions, proteins, enzymes etc.). Specifically, the present invention discloses a number of sorting schemes for stem cells, whole blood and circulating tumor cells, and extracting serum from whole blood.
FILED	Friday, July 24, 2015
APPL NO	14/808703
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 7/52 (20130101) B01L 2200/0652 (20130101) B01L 2200/0668 (20130101) B01L 2200/0673 (20130101) B01L 2300/0832 (20130101) B01L 2300/0861 (20130101) B01L 2300/0864 (20130101) B01L 2300/0883 (20130101) B01L 2300/1822 (20130101) B01L 2400/086 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 15/1056 (20130101) G01N 33/4833 (20130101)
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10232571 — Material tensioning system

US 10232571	Matlack et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	the boeing company (Chicago, Illinois)
INVENTOR(S)	Mike P. Matlack (St. Charles, Missouri); Stephen J. Morgan (Cypress, California); Thomas K. Tsotsis (Santa Ana, California); James R. Fox (University City, Missouri); Randall D. Wilkerson (O'Fallon, Missouri)
ABSTRACT	A system and method for forming an item from a material, which may include elongated fibers and/or stretched broken fibers. The material is placed on a first clamping portion, which is placed on a fixture. A second clamping portion is placed against the material and the first clamping portion and secured together, forming a clamping assembly. The clamping assembly is removed from the fixture and placed on a first die portion, having a first profile. A second die portion is also provided, having a second profile. In forming the item, at least one of the first die portion and the second die portion are moved toward each other such that a second surface of the first die portion and a first surface of the second die portion contact and form the material into the item generally replicating the first profile and the second profile.
FILED	Tuesday, September 22, 2015
APPL NO	14/861197
ART UNIT	1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/22 (20130101) B29C 70/46 (20130101) B29C 70/56 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2101/12 (20130101) B29K 2105/12 (20130101)
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10232761 — Unmanned underwater vehicle transport cart

US 10232761	Hooper et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	The United States of America (San Diego, California)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Ralph David Hooper (Lemon Grove, California); William A. Chambers (Jamul, California); Jeffery Towns Gilchrist (Cardiff, California)
ABSTRACT	An unmanned underwater vehicle (UUV) transport cart comprising: a wheeled frame including vertical posts, a front end, and a rear end; a UUV cradle adjustably clamped to the vertical posts such that the UUV cradle is vertically adjustable with respect to the frame; a U-shaped handle pivotally attached to the front end of the frame such that the U-shaped handle pivots up and down around a first axis, wherein the U-shaped handle includes a handle spring that acts between the U-shaped handle and the frame so as to bias the U-shaped handle toward an upward orientation; side handles pivotally attached to the UUV cradle such that the side handles pivot up and down around side axes that are perpendicular to the first axis; and a hand brake affixed to the U-shaped handle and configured to provide active brake control of the wheeled frame.
FILED	Wednesday, January 03, 2018
APPL NO	15/861480
ART UNIT	3618 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Buttons, Pins, Buckles, Slide Fasteners, or the Like A44B 13/02 (20130101) Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 3/10 (20130101) B60P 3/1075 (20130101) Original (OR) Class Hand-propelled Vehicles, e.g Hand Carts or Perambulators; Sledges B62B 3/02 (20130101) B62B 3/04 (20130101) B62B 5/067 (20130101) B62B 5/0438 (20130101) B62B 2005/0471 (20130101) B62B 2202/90 (20130101) B62B 2301/04 (20130101) Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/54 (20130101) B63B 21/60 (20130101) B63B 2027/165 (20130101) Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 2008/002 (20130101) Cranes; Load-engaging Elements or Devices for Cranes, Capstans, Winches, or Tackles B66C 1/36 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 45/02 (20130101) F16B 45/025 (20130101)
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10232914 — Pressure activated time-delayed release

US 10232914	Roth et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	SPAWAR Systems Center Pacific (San Diego, California)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Leif E. Roth (San Diego, California); Ryan J. Halonen (Durango, Colorado)
ABSTRACT	A pressure activated time-delayed release device and method. The device includes a body having a drive chamber and a compression chamber disposed therein, a drive piston disposed within the drive chamber of the body, and a compression piston disposed within the compression chamber of the body. A throttle mechanism is disposed between the drive piston and the compression piston. The throttle mechanism controls a release of viscous fluid from the drive chamber into the compression chamber. The drive piston and compression piston are connected so as to cause the compression piston to move substantially simultaneously with the drive piston to compress a compressible element disposed within the compression chamber. The device moves from an un-actuated state to an actuated state when the device is exposed to a predetermined water pressure for a predetermined period of time.
FILED	Wednesday, March 07, 2018
APPL NO	15/914140
ART UNIT	3652 — Material and Article Handling
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 69/08 (20130101) Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/08 (20130101) B63B 22/08 (20130101) Original (OR) Class B63B 35/26 (20130101)
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10232929 — Plate member for reducing drag on a fairing of an aircraft

US 10232929	Bowles et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Sikorsky Aircraft Corporation (Stratford, Connecticut)
ASSIGNEE(S)	SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut)
INVENTOR(S)	Patrick Bowles (Glastonbury, Connecticut); ByungYoung Min (Glastonbury, Connecticut); Barbara Brenda Botros (Vernon, Connecticut); Brian E. Wake (South Glastonbury, Connecticut); Claude G. Matalanis (Longmeadow, Massachusetts)
ABSTRACT	A rotary wing aircraft includes a fuselage having a plurality of surfaces, at least one engine mounted in the fuselage, and a rotor assembly including a rotor shaft and plurality of rotor blades operatively connected to the rotor shaft. The rotor assembly includes a plurality of surface portions. A rotor shaft fairing extends between the fuselage and the rotor assembly and about at least a portion of the rotor shaft. The rotor shaft fairing includes an outer surface. A plate member is mounted to and projects proudly of the at least a portion of the rotor shaft fairing. The plate member is configured and disposed to increase an aspect ratio of and reduce induced drag on the rotor shaft fairing as well as reduce rotor hub wake size.
FILED	Thursday, September 15, 2016
APPL NO	15/266692
ART UNIT	3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 7/00 (20130101) Original (OR) Class B64C 21/04 (20130101) B64C 27/10 (20130101) B64C 27/32 (20130101) B64C 27/82 (20130101) B64C 2027/8236 (20130101) B64C 2027/8272 (20130101) B64C 2027/8281 (20130101)
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10233261 — Natural polymer nanoparticles from ionic liquid emulsions

US 10233261	Alston et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia)
INVENTOR(S)	Jeffrey Alston (Valencia, California); Joseph Mabry (Lancaster, California); Andrew Guenthner (Lancaster, California)
ABSTRACT	A method of making natural polymer (nano)particles, comprises two immiscible phases and a surface active agent, wherein one phase includes a natural polymer source and ionic liquid; stirring the combined phases with surfactant to form a microemulsion; adjusting the ratios of ionic liquid, surfactant, and immiscible phase to determine a particular size of natural polymer nanoparticles; stirring antisolvent into the emulsion; diluting the emulsion; and washing and drying precipitated polymer (nano)particles from the emulsion. The immiscible phase comprises at least one of immiscible solvent, oil, or immiscible ionic liquid. The ionic liquid phase includes natural polymer dissolved in ionic solvent. The antisolvent is water, other protic solvent or additive. The emulsion is diluted with, more immiscible phase, 1-butanol, or a mutually miscible solvent, or oil. The emulsion is diluted with an excess of the volume of the emulsion. The precipitated polymer (nano)particles are washed (sequentially) with 1-butanol and water.
FILED	Wednesday, August 09, 2017
APPL NO	15/672365
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Polysaccharides; Derivatives Thereof C08B 16/00 (20130101) Original (OR) Class
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10233416 — Pressure manifold and culture module

US 10233416	Hinojosa et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	EMULATE, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	EMULATE, INC. (Boston, Massachusetts)
INVENTOR(S)	Christopher David Hinojosa (Cambridge, Massachusetts); Guy Robert Thompson, II (Watertown, Massachusetts); Joshua Gomes (Somerville, Massachusetts); Jacob Freake (Somerville, Massachusetts); Doug Sabin (Woburn, Massachusetts)
ABSTRACT	A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.
FILED	Friday, August 26, 2016
APPL NO	15/248690
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) A01N 1/0247 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502738 (20130101) B01L 2200/12 (20130101) B01L 2200/025 (20130101) B01L 2200/027 (20130101) B01L 2300/14 (20130101) B01L 2300/123 (20130101) B01L 2300/161 (20130101) B01L 2300/165 (20130101) B01L 2300/0681 (20130101) B01L 2300/0887 (20130101) B01L 2400/06 (20130101) B01L 2400/0481 (20130101) B01L 2400/0487 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/38 (20130101) C12M 23/40 (20130101) C12M 23/42 (20130101) C12M 29/10 (20130101) C12M 35/04 (20130101) C12M 41/40 (20130101) C12M 41/48 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101) C12N 2521/00 (20130101)
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10233441 — Capillary barriers for staged loading of microfluidic devices

US 10233441	Santiago et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Juan G. Santiago (Stanford, California); Lewis A. Marshall (Pleasanton, California); Anita Rogacs (Los Altos, California)
ABSTRACT	Various aspects of the present disclosure are directed toward methods and apparatuses for interacting a first liquid and a second liquid in one or more fluidic channels of a capillary structure. The methods and apparatuses can include providing at least one capillary barrier that positions a meniscus of the first liquid at a fluid-interface region using capillary forces within the capillary structure. Additionally, a path is provided along one of the channels for the second liquid to flow toward the fluid-interface region. Additionally, gas pressure is released, via a gas-outflow port, from the fluid-interface region while flow of the first liquid is arrested. Further, the first liquid and the second liquid contact in the fluid-interface region with the capillary barrier holding the first liquid at the fluid-interface region.
FILED	Friday, December 22, 2017
APPL NO	15/853370
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Separation B01D 57/02 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502723 (20130101) B01L 3/502738 (20130101) B01L 2200/10 (20130101) B01L 2200/027 (20130101) B01L 2200/0621 (20130101) B01L 2200/0631 (20130101) B01L 2200/0684 (20130101) B01L 2300/12 (20130101) B01L 2300/165 (20130101) B01L 2300/0838 (20130101) B01L 2300/0858 (20130101) B01L 2300/0867 (20130101) B01L 2400/086 (20130101) B01L 2400/088 (20130101) B01L 2400/0406 (20130101) B01L 2400/0421 (20130101) B01L 2400/0688 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/101 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101)
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10233764 — Fabric seal and assembly for gas turbine engine

US 10233764	Thomas et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Rolls-Royce North American Technologies, Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana)
ASSIGNEE(S)	Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana)
INVENTOR(S)	David J. Thomas (Brownsburg, Indiana); Richard C. Uskert (Timonium, Maryland); Thomas D. Nixon (Brownsburg, Indiana)
ABSTRACT	A vane assembly for a gas turbine engine is disclosed in this paper. The vane assembly includes an inner platform, an outer platform, and a ceramic-containing airfoil. The ceramic-containing airfoil extends from the inner platform to the outer platform. A clamp mechanism couples the inner platform and the outer platform to the ceramic-containing airfoil.
FILED	Monday, October 12, 2015
APPL NO	14/880660
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/042 (20130101) F01D 11/005 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/55 (20130101) F05D 2300/6012 (20130101) F05D 2300/6033 (20130101) F05D 2300/6034 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101)
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10233768 — Apparatus and process for optimizing turbine engine performance via load control through a power control module

US 10233768	Watts, III et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Florida Turbine Technologies, Inc. (Jupiter, Florida)
ASSIGNEE(S)	Florida Turbine Technologies, Inc. (Jupiter, Florida)
INVENTOR(S)	Oran A. Watts, III (Indianapolis, Indiana); John W Polywoda, III (Jupiter, Florida)
ABSTRACT	A power plant for an aircraft such as an unmanned aero vehicle in which a gas turbine engine drives an electric generator to produce electrical power for a system load of the aircraft. An engine control unit monitors engine performance and regulates engine power output through fuel flow control to a combustor. A power control module regulates power output of the generator to the system load and to a battery through a bus. A pulse width modulation is used between the power control module and the bus to optimize performance of the gas turbine engine instead of adjusting fuel flow to the combustor.
FILED	Thursday, March 22, 2018
APPL NO	15/928543
ART UNIT	2831 — Electrical Circuits and Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/042 (20130101) B64C 2201/048 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/10 (20130101) B64D 27/24 (20130101) B64D 2027/026 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 15/10 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 9/28 (20130101) F02C 9/263 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/76 (20130101) F05D 2220/323 (20130101) F05D 2270/303 (20130101)
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10233838 — Recuperated gas turbine engine

US 10233838	Vick
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Michael J. Vick (Vienna, Virginia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Michael J. Vick (Vienna, Virginia)
ABSTRACT	A gas turbine engine that includes a compressor, a turbine, a heat exchanger, and a combustor. The compressor is mounted on a rotating shaft with at least one rotor with an inlet and an outlet, and at least one diffuser downstream from each rotor. The turbine includes at least one stator, and at least one rotor with an inlet and outlet located downstream of each stator, and mounted on the rotating shaft as the at least one of the compressor rotors. The inlet of the compressor rotor faces toward the outlet of the turbine rotor. The heat exchanger is configured to preheat the compressed air leaving the compressor by transferring heat from the turbine exhaust. The combustor can be configured for mixing fuel with the compressed air, either upstream or downstream from the heat exchanger, and further configured for igniting the preheated fuel/air mixture located downstream from the heat exchanger.
FILED	Wednesday, September 09, 2015
APPL NO	14/849556
ART UNIT	3748 — Electrical Circuits and Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/284 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 1/10 (20130101) F02C 3/14 (20130101) F02C 7/08 (20130101) F02C 7/10 (20130101) Original (OR) Class F02C 7/22 (20130101) F02C 7/052 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2220/764 (20130101) F05D 2220/766 (20130101) F05D 2250/80 (20130101) F05D 2260/14 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 20/14 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101) Y02T 50/673 (20130101)
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10233842 — Tangential on-board injectors for gas turbine engines

US 10233842	Clum et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Carey Clum (East Hartford, Connecticut); Thomas N. Slavens (Moodus, Connecticut)
ABSTRACT	A tangential on-board injector (TOBI) for a gas turbine engine and methods of making the same are provided. The TOBI includes at least one adjustable strut configured to control an airflow through the TOBI, the at least one adjustable strut moveable to change an airflow characteristic within the TOBI.
FILED	Friday, January 08, 2016
APPL NO	14/991064
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/081 (20130101) F01D 5/082 (20130101) F01D 25/12 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/18 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/00 (20130101) F05D 2230/60 (20130101) F05D 2260/20 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/676 (20130101)
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10233844 — System for thermally shielding a portion of a gas turbine shroud assembly

US 10233844	Bogard et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Justin H. Bogard (Atlanta, Georgia); Jason David Shapiro (Methuen, Massachusetts)
ABSTRACT	In one aspect the present subject matter is directed to a system for thermally shielding a portion of a shroud assembly for a gas turbine. The system includes a shroud support having a forward wall that includes a front side that is axially spaced from a back side and a radially inner surface that extends axially between the front and back sides. A shroud is mounted to the shroud support. The shroud includes a leading edge portion that extends towards the forward wall of the shroud support and a trailing edge portion that extends towards the aft wall of the shroud support. A radial gap is defined between a top surface of the leading edge portion and the radially inner surface of the forward wall. A thermal shield is disposed along a bottom portion of the forward wall and is oriented to face towards a flow of combustion gases.
FILED	Monday, May 11, 2015
APPL NO	14/708385
ART UNIT	3748 — Printing/Measuring and Testing
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/08 (20130101) F01D 11/005 (20130101) F01D 11/08 (20130101) F01D 25/08 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) F02C 7/24 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/11 (20130101) F05D 2240/15 (20130101) F05D 2260/231 (20130101) F05D 2300/6033 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101) Y02T 50/676 (20130101)
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10233910 — Flexible thin robotic actuators

US 10233910	Mazzeo et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Aaron D. Mazzeo (Duenellen, New Jersey); Stephen A. Morin (Lincoln, Nebraska); Robert F. Shepherd (Brooktondale, New York); George M. Whitesides (Newton, Massachusetts); William B. Kalb (Cambridge, Massachusetts)
ABSTRACT	Some embodiments of the disclosed subject matter includes a laminated robotic actuator. The laminated robotic actuator includes a strain-limiting layer comprising a flexible, non-extensible material in the form of a sheet or thin film, a flexible inflatable layer in the form of a thin film or sheet in facing relationship with the strain-limiting layer, wherein the inflatable layer is selectively adhered to the strain-limiting layer, and wherein a portion of an un-adhered region between the strain-limiting layer and the inflatable layer defines a pressurizable channel, and at least one fluid inlet in fluid communication with the pressurizable channel. The first flexible non-extensible material has a stiffness that is greater than the stiffness of the second flexible elastomeric material and the flexible elastomer is non-extensible under actuation conditions.
FILED	Monday, November 28, 2016
APPL NO	15/362334
ART UNIT	3748 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Manipulators; Chambers Provided With Manipulation Devices B25J 9/142 (20130101) B25J 9/1075 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) Original (OR) Class Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/103 (20130101)
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10233953 — Connector for non-cylindrical composite tubing and methods for making the same

US 10233953	McGann et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Shawn Kerry McGann (Ridgecrest, California); Nicholas McGaha (Ridgecrest, California)
ABSTRACT	A connector for non-cylindrical composite tubing and methods for making the same. The method may involve assembling a connector for a non-cylindrical composite tubing by loosely fastening a pair of bonding plates to an end plate; arranging the bonding plates in an inward configuration; applying an epoxy adhesive onto the outer faces of the bonding plates, inserting the bonding plates into the open end of the composite tubing, inserting the bonding plate fasteners through the through-holes of the composite tubing and tightly fastening the bonding plate fasteners into the bonding plates until the bonding plates engage against the inner surface of the composite tubing until the epoxy adhesive is uniformly distributed. The method may also include steps of removing the bonding plate screw fasteners and adding shims between each bonding plate and the inner surface of the composite tubing in order to maintain a predetermined thickness of the epoxy adhesive.
FILED	Tuesday, November 21, 2017
APPL NO	15/819938
ART UNIT	1713 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 65/48 (20130101) B29C 65/561 (20130101) B29C 66/022 (20130101) B29C 66/026 (20130101) B29C 66/5221 (20130101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/20 (20130101) Cleaning or Degreasing of Metallic Material by Chemical Methods Other Than Electrolysis C23G 1/00 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 5/02 (20130101) Original (OR) Class F16B 11/006 (20130101) Technical Subjects Covered by Former US Classification Y10T 403/472 (20150115)
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10234172 — Localized solar collectors

US 10234172	Ni et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	George Ni (Ann Arbor, Michigan); Gang Chen (Carlisle, Massachusetts); Svetlana V. Boriskina (Winchester, Massachusetts); Thomas Alan Cooper (Boston, Massachusetts)
ABSTRACT	A localized heating structure includes a spectrally-selective solar absorber, that absorbs incident solar radiation and reflects at wavelengths longer than 2 μm, with an underlying heat-spreading layer having a thermal conductivity equal to or greater than 50 W/(mK), a thermally insulating layer, adjacent to the spectrally-selective solar absorber, having a thermal conductivity of less than 0.1 W/(mK), one or more evaporation openings through the spectrally-selective solar absorber and the thermally insulating layer, and an evaporation wick, disposed in one or more of the evaporation openings in the thermally insulating layer, that contacts liquid and allows the liquid to be transported from a location beneath the thermally insulating layer through to the spectrally-selective solar absorber in order to generate vapor from the liquid. The thermally insulating layer is configured to have a density less than the liquid so that the localized heating structure is able to float on the liquid.
FILED	Monday, October 03, 2016
APPL NO	15/283914
ART UNIT	1788 — Miscellaneous Articles, Stock Material
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/18 (20130101) B32B 5/32 (20130101) B32B 2266/06 (20130101) Compositions of Macromolecular Compounds C08L 83/02 (20130101) Methods of Steam Generation; Steam Boilers F22B 1/006 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 10/17 (20180501) F24S 10/80 (20180501) F24S 20/25 (20180501) F24S 20/50 (20180501) Original (OR) Class F24S 70/10 (20180501) F24S 80/56 (20180501) F24S 80/65 (20180501) F24S 90/00 (20180501) F24S 2080/014 (20180501) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/44 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49826 (20150115) Y10T 428/249967 (20150401) Y10T 428/249969 (20150401)
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10234248 — Micro-electric-pyrotechnic energy-harvesting apparatus for munitions

US 10234248	Hoang et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Department of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Thinh Hoang (Beltsville, Maryland); Khoa Nguyen (Waldorf, Maryland); Daniel Corey Pines (Alexandria, Virginia); Troy Caruso (Sterling Heights, Michigan)
ABSTRACT	A micro-electro-pyrotechnic energy-harvesting apparatus to harvest an incidental portion of a propellant energy utilized when a munition is fired freeing a magnet to strike an impact pin that strains a piezoelectric element. The piezoelectric element generates a collected voltage, which triggers a pyrotechnic initiator that, on activation, produces a straining force on a plurality of stacks of piezoelectric elements. The strained piezoelectric elements, in turn, generate a high voltage output sufficient to ignite the munition's explosive material. The apparatus may be quite small, for example, the cross-sectional size of a pen, which is about one centimeter, yet suitable for generating an electrical ignition of the explosive material.
FILED	Monday, June 12, 2017
APPL NO	15/731440
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 3/124 (20130101) Original (OR) Class Ammunition Fuzes; Arming or Safety Means Therefor F42C 11/02 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/083 (20130101) Electric Machines Not Otherwise Provided for H02N 2/183 (20130101)
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10234285 — Device and method for multifunction relative alignment and sensing

US 10234285	Goldstein
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	David J. Goldstein (Alexandria, Virginia)
ABSTRACT	A tiltmeter-integrated two element optical relative alignment monitor provides relative alignment and contact sensing and can provide precise information regarding the nature of physical contact experienced by objects being monitored. A computer monitor can display the information in real time, in an intuitive manner. This system can provide all the information with good resolution in a low-cost, easily installable package for a wide variety of research, high energy physics applications, and industrial uses. A projector unit is mounted on one component containing a diffuse light source, a coded mask, and a lens. The projector is aligned with a camera to receive the focused image. Shifts in the image of the mask indicate relative motion between the camera and the projector unit. A tiltmeter is affixed to either the camera or projector, to distinguish between image shifts due to translational movement and image shifts due to rotation or tilting.
FILED	Monday, September 12, 2016
APPL NO	15/262351
ART UNIT	2482 — Recording and Compression
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 9/02 (20130101) Original (OR) Class G01C 11/06 (20130101) G01C 2009/066 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) Pictorial Communication, e.g Television H04N 5/2256 (20130101)
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10234358 — Optical time domain reflectometer with high resolution and high sensitivity

US 10234358	Ahadian et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Ultra Communications, Inc. (Vista, California)
ASSIGNEE(S)	Ultra Communications, Inc. (Vista, California)
INVENTOR(S)	Joseph F. Ahadian (San Marcos, California); Kris Kusumoto (Lemon Grove, California); Charles B. Kuznia (Encinitas, California)
ABSTRACT	An optical time domain reflectometer (OTDR) system with an integrated high speed optical modulator is capable of operating at a speed similar to the OTDR pulse width to improve the measurement resolution and reduce the time required to acquire a high dynamic range OTDR measurement over existing approaches. ASICs can be used to control the modulator and generation of pulses. The high-speed optical modulator enables high resolution single-photon OTDR measurement by blocking out all return light except from the region of fiber under examination.
FILED	Wednesday, April 11, 2018
APPL NO	15/951074
ART UNIT	2886 — Optics
CURRENT CPC	Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/3109 (20130101) Original (OR) Class G01M 11/3145 (20130101)
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10234394 — Method for highly sensitive detection of biomarkers for diagnostics

US 10234394	Chou et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Stephen Y. Chou (Princeton, New Jersey); Liang-Cheng Zhou (Princeton, New Jersey)
ABSTRACT	This disclosure provides, among other things, a nanosensor comprising a substrate and one or a plurality of pillars extending from a surface of the substrate, where the pillars comprise a metallic dot structure, a metal disc, and a metallic back plane. The nanosensor comprises a molecular adhesion layer that covers at least a part of the metallic dot structure, the metal disc, and/or the metallic back plane and a capture agent bound to the molecular adhesion layer. The nanosensor amplifies a light signal from an analyte, when the analyte is specifically bound to the capture agent.
FILED	Wednesday, March 25, 2015
APPL NO	14/668750
ART UNIT	2877 — Optics
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/648 (20130101) G01N 21/658 (20130101) G01N 21/6428 (20130101) G01N 21/6486 (20130101) Original (OR) Class G01N 2021/6439 (20130101) G01N 2201/06113 (20130101)
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10234410 — Stable binary nanocrystalline alloys and methods of identifying same

US 10234410	Murdoch et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Heather A. Murdoch (Baltimore, Maryland); Christopher A. Schuh (Wayland, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Heather A. Murdoch (Baltimore, Maryland); Christopher A. Schuh (Wayland, Massachusetts)
ABSTRACT	Identifying a stable phase of a binary alloy comprising a solute element and a solvent element. In one example, at least two thermodynamic parameters associated with grain growth and phase separation of the binary alloy are determined, and the stable phase of the binary alloy is identified based on the first thermodynamic parameter and the second thermodynamic parameter, wherein the stable phase is one of a stable nanocrystalline phase, a metastable nanocrystalline phase, and a non-nanocrystalline phase.
FILED	Monday, March 12, 2012
APPL NO	14/384518
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Alloys C22C 1/00 (20130101) C22C 5/02 (20130101) C22C 5/04 (20130101) C22C 5/06 (20130101) C22C 7/00 (20130101) C22C 11/00 (20130101) C22C 12/00 (20130101) C22C 13/00 (20130101) C22C 16/00 (20130101) C22C 20/00 (20130101) C22C 22/00 (20130101) C22C 24/00 (20130101) C22C 27/00 (20130101) C22C 27/02 (20130101) C22C 27/04 (20130101) C22C 27/06 (20130101) C22C 27/025 (20130101) C22C 28/00 (20130101) C22C 38/002 (20130101) C22C 43/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/02 (20130101) G01N 25/12 (20130101) Original (OR) Class G01N 33/20 (20130101)
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10234514 — System and method for broadband far and near field radio frequency radiation detection using superconducting quantum detector arrays

US 10234514	Leese de Escobar et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	Anna M. Leese de Escobar (Encinitas, California); Marcio Calixto de Andrade (San Diego, California); Susan Anne Elizabeth Berggren (San Diego, California); Robert Lewis Fagaly (Carlsbad, California); Benjamin Jeremy Taylor (Escondido, California)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Anna M. Leese de Escobar (Encinitas, California); Marcio Calixto de Andrade (San Diego, California); Susan Anne Elizabeth Berggren (San Diego, California); Robert Lewis Fagaly (Carlsbad, California); Benjamin Jeremy Taylor (Escondido, California)
ABSTRACT	An antenna includes a plurality of superconducting quantum interference device (SQUID) arrays on a chip, and a printed circuit board (PCB) formed with a cutout for receiving the chip. The PCB is formed with a set of coplanar transmission lines, and the chip is inserted into the cutout so that each said transmission line connects to a respective SQUID array. A cryogenic system can cool the chip to a temperature that causes a transition to superconductivity for the SQUID arrays. A thermal radome can be placed around the chip, the PCB and the cryogenic system to maintain the temperature. A DC bias can be applied to the SQUID arrays to facilitate RF detection. The SQUID array, chip and CPW transmission lines can cooperate to allow for both detection of said RF energy and conversion of said RF energy to a signal without requiring the use of a conductive antenna dish.
FILED	Wednesday, November 23, 2016
APPL NO	15/360323
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0023 (20130101) G01R 33/0076 (20130101) G01R 33/0354 (20130101) Original (OR) Class
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10234533 — Position determination by observing a celestial object transit the sun or moon

US 10234533	Lane et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)	The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts)
INVENTOR(S)	Benjamin F. Lane (Sherborn, Massachusetts); William W. Whitacre (Boston, Massachusetts)
ABSTRACT	A navigation system determines a position by referring to artificial or natural satellites or other space objects during daylight or when the objects are in a planet's shadow. A telescope and image sensor observe and image shadows of the objects as the objects transit the sun or a sunlit surface of a planet or moon, thereby solving problems related to the two key times during which traditional SkyMark navigation is difficult or impossible.
FILED	Friday, September 09, 2016
APPL NO	15/261316
ART UNIT	3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/02 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 3/785 (20130101) Original (OR) Class G01S 3/7867 (20130101) G01S 5/0263 (20130101) G01S 19/48 (20130101)
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10234534 — Kalman filtered correlation interferometry geolocation

US 10234534	Kabel
FUNDED BY	Department of Defense (DOD) Defense MicroElectronics Activity (DMEA)
APPLICANT(S)	BAE SYSTEMS INFORMATION AND ELECTRONIC SYSTEMS INTEGRATION INC. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Allan M. Kabel (Hollis, New Hampshire)
ABSTRACT	A method and system for Kalman-Filtering in geolocation is provided. One aspect of the disclosure provides using an extreme geo program/method to converge on the location of an emitter, using a correlation function inherent in a Correlation Interferometry Geolocation (CIGL) program, and using Kalman filtering to find a peak correlation surface for an array.
FILED	Thursday, September 22, 2016
APPL NO	15/273258
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0205 (20130101) Original (OR) Class G01S 5/0252 (20130101)
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10234543 — Methods and systems for locating targets using non linear radar with a matched filter which uses exponential value of the transmit signal

US 10234543	Mazzaro et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Gregory J. Mazzaro (Charleston, South Carolina); Kyle A. Gallagher (Derwood, Maryland); Kenneth I. Ranney (Rockville, Maryland); Anthony F. Martone (Ellicott City, Maryland)
ABSTRACT	Embodiments of the present invention concern locating targets using non-linear radar with a matched filter which uses exponential value of the transmit signal. According to embodiments, a method of non-linear radar target location includes: transmitting a signal of a transmit waveform towards a target; receiving a signal from the target; creating a matched filter by generating an exponential function of the transmit waveform corresponding to a particular harmonic of the interest; and applying the matched filter to the received signal to generate and output a signature waveform for the target of the particular harmonic of interest. In other embodiments, the matched filtering may be combined with sidelobe reduction.
FILED	Wednesday, April 20, 2016
APPL NO	15/133276
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/354 (20130101) G01S 7/414 (20130101) Original (OR) Class G01S 13/32 (20130101) G01S 13/0209 (20130101)
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10234701 — Waveguide array modulator for high performance systems

US 10234701	Morton et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Morton Photonics (West Friendship, Maryland)
ASSIGNEE(S)	Morton Photonics (West Friendship, Maryland)
INVENTOR(S)	Paul A. Morton (West Friendship, Maryland); Jacob Khurgin (Pikesville, Maryland)
ABSTRACT	In the Waveguide Array Modulator (WAM) a single electrical signal drives an array of waveguide optical modulators, creating multiple modulated output signals that can be combined to provide a higher output power than from a single waveguide based modulator, enabling a higher dynamic range system. Alternatively, using a WAM in which different waveguide optical modulators are designed for different dynamic ranges, e.g. one highly efficient modulator for low level signals and one low efficiency but linear modulator for high level signals, the WAM based system can provide a higher dynamic range than from a single waveguide based modulator. Various WAM based systems for different applications are included.
FILED	Wednesday, October 18, 2017
APPL NO	15/787008
ART UNIT	2883 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0121 (20130101) Original (OR) Class G02F 1/2257 (20130101) G02F 2001/212 (20130101) G02F 2201/02 (20130101) G02F 2201/18 (20130101) G02F 2203/58 (20130101) G02F 2203/70 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/38 (20130101) H03H 7/48 (20130101)
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10234702 — In-situ ring-resonator-modulator calibration

US 10234702	Amberg et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Oracle International Corporation (Redwood Shores, California)
ASSIGNEE(S)	Oracle International Corporation (Redwood Shores, California)
INVENTOR(S)	Philip Amberg (El Cajon, California); Eric Y. Chang (San Mateo, California); Frankie Y. Liu (Palo Alto, California)
ABSTRACT	In an optical device, a ring-resonator modulator, having an adjustable resonance (center) wavelength, receives an optical signal that includes a carrier wavelength from an input-output optical waveguide. Then, a monitoring mechanism monitors a performance metric (such as an average power or a signal swing) of a monitor optical signal from the ring-resonator modulator. Moreover, control logic in the optical device adjusts the resonance wavelength based on the monitored performance metric so that the resonance wavelength is locked to the carrier wavelength. In particular, the control logic may apply a change to an adjustment signal that is provided to the ring-resonator modulator. If the change increases the performance metric, the control logic may continue to modify the resonance wavelength. Otherwise, the control logic may modify the resonance wavelength by applying one or more changes, having an opposite sign to the change, to the adjustment signal.
FILED	Tuesday, May 08, 2018
APPL NO	15/974313
ART UNIT	2874 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/025 (20130101) G02F 1/0121 (20130101) Original (OR) Class G02F 1/3132 (20130101) G02F 2201/58 (20130101) G02F 2203/15 (20130101)
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10234944 — Force feedback system including multi-tasking graphical host environment

US 10234944	Braun et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC)
APPLICANT(S)	Immersion Corporation (San Jose, California)
ASSIGNEE(S)	IMMERSION CORPORATION (San Jose, California)
INVENTOR(S)	Adam C. Braun (Portland, Oregon); Jonathan L. Beamer (Lyndhurst, Ohio); Dean C. Chang (Gaithersburg, Maryland)
ABSTRACT	A force feedback system provides components for use in a force feedback system including a host computer and a force feedback interface device. An architecture for a host computer allows multi-tasking application programs to interface with the force feedback device without conflicts. One embodiment of a force feedback device provides both relative position reporting and absolute position reporting to allow great flexibility. A different device embodiment provides relative position reporting device allowing maximum compatibility with existing software. Information such as ballistic parameters and screen size sent from the host to the force feedback device allow accurate mouse positions and graphical object positions to be determined in the force feedback environment. Force feedback effects and structures are further described, such as events and enclosures.
FILED	Friday, April 15, 2016
APPL NO	15/130190
ART UNIT	3649 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Electric Digital Data Processing G06F 3/016 (20130101) Original (OR) Class G06F 3/0481 (20130101) G06F 3/03543 (20130101) G06F 3/04812 (20130101) G06F 2203/014 (20130101)
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10235215 — Memory lock mechanism for a multiprocessor system

US 10235215	Arimilli et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Lakshminarayana B. Arimilli (Austin, Texas); Ravi K. Arimilli (Austin, Texas); Guy L. Guthrie (Austin, Texas); William J. Starke (Round Rock, Texas)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Lakshminarayana B. Arimilli (Austin, Texas); Ravi K. Arimilli (Austin, Texas); Guy L. Guthrie (Austin, Texas); William J. Starke (Round Rock, Texas)
ABSTRACT	A memory lock mechanism within a multi-processor system is disclosed. A lock control section is initially assigned to a data block within a system memory of the multiprocessor system. In response to a request for accessing the data block by a processing unit within the multiprocessor system, a determination is made by a memory controller whether or not the lock control section of the data block has been set. If the lock control section of the data block has been set, the request for accessing the data block is denied. Otherwise, if the lock control section of the data block has not been set, the lock control section of the data block is set, and the request for accessing the data block is allowed.
FILED	Friday, February 01, 2008
APPL NO	12/024169
ART UNIT	2167 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 9/526 (20130101) Original (OR) Class G06F 9/3004 (20130101) G06F 9/30087 (20130101) G06F 17/30171 (20130101) G06F 17/30362 (20130101)
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10235577 — Maneuverless passive range estimation using monocular image sequences

US 10235577	Avadhanam et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA)
APPLICANT(S)	UtopiaCompression Corporation (Los Angeles, California)
ASSIGNEE(S)	UtopiaCompression Corporation (Los Angeles, California)
INVENTOR(S)	Sharath Avadhanam (Los Angeles, California); Sameer Sheorey (Los Angeles, California); He Bai (Los Angeles, California); Joseph Yadegar (Los Angeles, California)
ABSTRACT	A method to estimate range to a moving rigid body from a moving platform using a monocular camera. The method does not require the camera platform to maneuver in order to estimate range. The method relies on identification and tracking of certain principal features of the object. The method extracts a silhouette of an object from an obtained image and identifies two principal linear components of the silhouette. A normalized distance between the point of intersection of the two linear components and a centroid of the silhouette is computed, compared to a data set and used to determine a direction of movement of the object.
FILED	Monday, April 25, 2016
APPL NO	15/138146
ART UNIT	2487 — Recording and Compression
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00805 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/2033 (20130101) G06T 2207/10028 (20130101) G06T 2207/30261 (20130101) Pictorial Communication, e.g Television H04N 7/18 (20130101)
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10235734 — Translation of artificial intelligence representations

US 10235734	Riabov et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Anton V. Riabov (Ann Arbor, Michigan); Shirin Sohrabi Araghi (Port Chester, New York); Octavian Udrea (Ossining, New York)
ABSTRACT	Techniques for translating graphical representations of domain knowledge are provided. In one example, a computer-implemented method comprises receiving, by a device operatively coupled to a processor, a graphical representation of domain knowledge. The graphical representation comprises information indicative of a central concept and at least one chain of events associated with the central concept. The computer-implemented method further comprises translating, by the device, the graphical representation into an artificial intelligence planning problem. The artificial intelligence planning problem is expressed in an artificial intelligence description language. The translating comprises parsing the graphical representation into groupings of terms. A first grouping of terms of the grouping of terms comprises an event from the at least one chain of events and a second grouping of terms of the grouping of terms comprises the information indicative of the central concept. The computer-implemented method also comprises validating, by the device, the artificial intelligence planning problem.
FILED	Friday, January 27, 2017
APPL NO	15/418418
ART UNIT	2616 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC	Electric Digital Data Processing G06F 15/18 (20130101) G06F 17/30277 (20130101) Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) Image Data Processing or Generation, in General G06T 1/20 (20130101) Original (OR) Class
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10235755 — High-throughput adaptive sampling for whole-slide histopathology image analysis

US 10235755	Madabhushi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Anant Madabhushi (Shaker Heights, Ohio); Angel Alfonso Cruz Roa (Villavicencio, Colombia); Fabio Gonzalez (Bogota, Colombia)
ABSTRACT	Methods, apparatus, and other embodiments associated with classifying a region of tissue represented in a digitized whole slide image (WSI) using iterative gradient-based quasi-Monte Carlo (QMC) sampling. One example apparatus includes an image acquisition circuit that acquires a WSI of a region of tissue demonstrating cancerous pathology, an adaptive sampling circuit that selects a subset of tiles from the WSI using an iterative QMC Sobol sequence sampling approach, an invasiveness circuit that determines a probability of a presence of invasive pathology in a member of the subset of tiles, a probability map circuit that generates an invasiveness probability map based on the probability, a probability gradient circuit that generates a gradient image based on the invasiveness probability map, and a classification circuit that classifies the region of tissue based on the probability map. A prognosis or treatment plan may be provided based on the classification of the WSI.
FILED	Friday, June 29, 2018
APPL NO	16/023361
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 10/0041 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/627 (20130101) G06K 9/4604 (20130101) G06K 9/4628 (20130101) G06K 9/4642 (20130101) G06K 9/6269 (20130101) G06K 9/6277 (20130101) G06K 2209/051 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10024 (20130101) G06T 2207/10056 (20130101) G06T 2207/20021 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 50/20 (20180101)
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10236118 — Wireless energy coil arrangement

US 10236118	Bana et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Viktor Bana (San Diego, California); John D. Rockway (San Diego, California); Gregory W. Anderson (San Diego, California); Alex Phipps (San Diego, California); Wayne P. Liu (San Diego, California)
ABSTRACT	A system and method are provided for wirelessly transmitting energy from a transmitter platform to a receiver platform. The system reduces the number of coils on the receiver platform to one, while the remaining coils are located on the transmitter platform. The spacing of the coils on the transmitting platform can be adjusted to optimize the magnetic flux transfer to the single coil on the receiving platform based on the unique distance between the transmitter and receiver platforms.
FILED	Thursday, August 25, 2016
APPL NO	15/246996
ART UNIT	2836 — Electrical Circuits and Systems
CURRENT CPC	Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 11/182 (20130101) B60L 2200/10 (20130101) B60L 2200/32 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 38/14 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/025 (20130101) H02J 50/12 (20160201)
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10236135 — Ni(OH)2 nanoporous films as electrodes

US 10236135	Tour et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	James M. Tour (Bellaire, Texas); Yang Yang (Beijing, China PRC)
ASSIGNEE(S)	WILLIAM MARSH RICE UNIVERSITY (Houston, Texas)
INVENTOR(S)	James M. Tour (Bellaire, Texas); Yang Yang (Beijing, China PRC)
ABSTRACT	The present disclosure pertains to electrodes that include a nickel-based material and at least one porous region with a plurality of nickel hydroxide moieties on a surface of the nickel-based material. The nickel-based material may be a nickel foil in the form of a film. The porous region of the electrode may be directly associated with the surface of the nickel-based material. The nickel hydroxide moieties may be in crystalline form and embedded with the porous region. The electrodes of the present disclosure may be a component of an energy storage device, such as a capacitor. Additional embodiments of the present disclosure pertain to methods of fabricating the electrodes by anodizing a nickel-based material to form at least one porous region on a surface of the nickel-based material; and hydrothermally treating the porous region to form nickel hydroxide moieties associated with the porous region.
FILED	Monday, June 27, 2016
APPL NO	15/193529
ART UNIT	1761 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 9/06 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/26 (20130101) H01G 11/30 (20130101) Original (OR) Class H01G 11/68 (20130101) H01G 11/86 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/52 (20130101) H01M 4/0442 (20130101) H01M 4/0471 (20130101) H01M 4/661 (20130101) H01M 4/8817 (20130101) H01M 4/8853 (20130101) H01M 4/9016 (20130101) H01M 8/0206 (20130101) H01M 8/0232 (20130101) H01M 2004/021 (20130101)
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10236154 — Method and apparatus for a porous electrospray emitter

US 10236154	Lozano et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA Air Force Office of Scientific Research (AFOSR) Asian Office of Aerospace Research and Development (AOARD)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Paulo C. Lozano (Arlington, Massachusetts); Steven Mark Arestie (Redondo Beach, California)
ABSTRACT	An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. The body can have a pore size gradient that decreases from the base of the body to the tip of the body, such that the at least one of an ionic liquid or room-temperature molten salt is capable of being transported through capillarity from the base to the tip.
FILED	Monday, November 06, 2017
APPL NO	15/805050
ART UNIT	2881 — Optics
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/14 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 1/05 (20130101) H01J 9/02 (20130101) H01J 37/08 (20130101) Original (OR) Class H01J 49/0445 (20130101) H01J 2237/317 (20130101) H01J 2237/0802 (20130101)
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10236165 — Metamaterial photocathode for detection and imaging of infrared radiation

US 10236165	Conley
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Surface Warfare Center (NSWC)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Benjamin R Conley (Bloomington, Indiana)
ABSTRACT	Exemplary metamaterial photocathodes enable detection of light from visible through long wave infrared wavelengths. Metamaterial stacks, comprising gold, silicon, and cesium-oxide, coupled to a semiconductor allow hot electrons to efficiently enter a vacuum. The hot electrons are multiplied in a multichannel plate and directly through another vacuum towards a phosphorus screen.
FILED	Saturday, August 04, 2018
APPL NO	16/055080
ART UNIT	2884 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 40/06 (20130101) Original (OR) Class H01J 40/16 (20130101) H01J 43/246 (20130101) H01J 47/00 (20130101) H01J 49/08 (20130101) Pictorial Communication, e.g Television H04N 5/332 (20130101)
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10236365 — Homoepitaxial tunnel barriers with hydrogenated graphene-on-graphene for room temperature electronic device applications

US 10236365	Friedman et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Adam L. Friedman (Silver Spring, Maryland); Olaf M. J. van 't Erve (Falls Church, Virginia); Jeremy T. Robinson (Washington, District of Columbia); Berend T. Jonker (Waldorf, Maryland); Keith E. Whitener (Alexandria, Virginia)
ABSTRACT	A homoepitaxial, ultrathin tunnel barrier-based electronic device in which the tunnel barrier and transport channel are made of the same material—graphene.
FILED	Tuesday, January 30, 2018
APPL NO	15/883935
ART UNIT	2896 — Optics
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/041 (20130101) H01L 21/042 (20130101) H01L 21/0259 (20130101) H01L 21/0262 (20130101) H01L 21/0435 (20130101) H01L 21/02104 (20130101) H01L 21/02527 (20130101) H01L 21/02634 (20130101) H01L 29/88 (20130101) H01L 29/0895 (20130101) H01L 29/1606 (20130101) H01L 29/66015 (20130101) H01L 29/66984 (20130101) Original (OR) Class H01L 43/02 (20130101) H01L 43/10 (20130101) H01L 43/12 (20130101)
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10236460 — Photovoltaic cell enhancement through UVO treatment

US 10236460	So et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC) Basic Energy Sciences (BES)
APPLICANT(S)	Franky So (Gainesville, Florida); John R. Reynolds (Dunwoody, Georgia); Song Chen (Gainesville, Florida); Cephas Small (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainsville, Florida)
INVENTOR(S)	Franky So (Gainesville, Florida); John R. Reynolds (Dunwoody, Georgia); Song Chen (Gainesville, Florida); Cephas Small (Gainesville, Florida)
ABSTRACT	Photovoltaic cells, methods of fabricating photovoltaic cells, and methods of using photovoltaic cells to capture light energy are provided. A photovoltaic cell can include an electron transporting layer, a photoactive layer, and a hole transporting layer. The electron transporting layer can be ultraviolet ozone treated. The photovoltaic cell can have an inverted configuration.
FILED	Monday, July 23, 2012
APPL NO	13/555794
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/442 (20130101) Original (OR) Class H01L 51/4253 (20130101) H01L 2251/308 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101)
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10236590 — Foldable segmented structure and deployable reflector antenna comprised thereof

US 10236590	Footdale et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Joseph N. Footdale (Albuquerque, New Mexico); Jeremy Banik (Albuquerque, New Mexico); Jeremiah Sanders (Cedar Hill, Texas)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary of the Air Force (Washington, District of Columbia)
INVENTOR(S)	Joseph N. Footdale (Albuquerque, New Mexico); Jeremy Banik (Albuquerque, New Mexico); Jeremiah Sanders (Cedar Hill, Texas)
ABSTRACT	A foldable segmented structure includes a substantially center portion and a plurality of strut assemblies radially disposed around the center portion. Each strut assembly includes an inner and outer strut. The inner strut includes a first end portion rotatably coupled at the center portion and a second end portion rotatably coupled to the outer strut at an intermediate portion of the strut assembly. The intermediate portion is spaced apart from the center portion. At least one shell segment is disposed on at least one of the inner and outer strut. Each inner strut is configured to rotatably articulate about the first end portion in a first angular direction. Each outer strut is configured to rotatably articulate about the second end portion in a second angular direction opposite to the first angular direction to form an axially extending structure from the center portion to the intermediate portion in a stowed configuration.
FILED	Wednesday, December 21, 2016
APPL NO	15/387555
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 15/161 (20130101) H01Q 15/162 (20130101) Original (OR) Class
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10236593 — Stacked patch antenna array with castellated substrate

US 10236593	Dufilie et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Pierre A. Dufilie (Boston, Massachusetts); Jeffrey S. Herd (Rowley, Massachusetts)
ABSTRACT	Described is a printed circuit antenna array including at least one castellated substrate. Also described is a stacked patch antenna array having at least one castellated substrate.
FILED	Tuesday, September 27, 2016
APPL NO	15/277346
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/38 (20130101) H01Q 1/48 (20130101) H01Q 1/288 (20130101) H01Q 9/0414 (20130101) H01Q 21/065 (20130101) Original (OR) Class H01Q 21/0093 (20130101)
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10236825 — Bipolar junction transistor based switched capacitors

US 10236825	Valdes Garcia et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Alberto Valdes Garcia (Hartsdale, New York); Bodhisatwa Sadhu (White Plains, New York); Jahnavi Sharma (New York, New York)
ABSTRACT	A switched capacitor is provided. The switched capacitor includes a pair of parallel component stacks. Each stack is connected to a common top node and a common bottom node. Each stack includes a BJT. Each stack further includes a first resistor in series with the BJT and having a first side connected to a collector of the BJT at an intermediate node in a same one of the stacks and a second side connected to the common top node. Each stack also includes a capacitor having a first side connected to the intermediate node and a second side for providing an impedance. Each stack additionally includes a second resistor having a first side connected to a base of the BJT to prevent base-current surge in the BJT and a second side connected to a switch base control signal that selectively turns the BJT on or off.
FILED	Tuesday, October 03, 2017
APPL NO	15/723841
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 5/1206 (20130101) H03B 5/1215 (20130101) H03B 5/1231 (20130101) H03B 5/1265 (20130101) Original (OR) Class H03B 2200/009 (20130101) H03B 2200/0062 (20130101)
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10237059 — Diversified instruction set processing to enhance security

US 10237059	Sethumadhavan et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Lakshminarasimhan Sethumadhavan (New York, New York); Kanad Sinha (New York, New York); Angelos Keromytis (New York, New York); Vasileios Pappas (New York, New York); Vasileios Kemerlis (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Lakshminarasimhan Sethumadhavan (New York, New York); Kanad Sinha (New York, New York); Angelos Keromytis (New York, New York); Vasileios Pappas (New York, New York); Vasileios Kemerlis (New York, New York)
ABSTRACT	Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method that includes receiving a block of information from non-processor memory at an interface between the non-processor memory and processor memory comprising two or more processor memory levels, determining whether the block of information received from the non-processor memory at the interface corresponds to encrypted instruction code, and decrypting the block of information at the interface between the non-processor memory and the processor memory for storage in one of the two or more levels of the processor memory in response to a determination that the received block of information corresponds to the encrypted instruction code. The block of information is stored at the one of the two or more levels of the processor memory without being decrypted when the received block of information is determined to correspond to data.
FILED	Friday, November 20, 2015
APPL NO	14/946961
ART UNIT	2492 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 9/30178 (20130101) G06F 12/0897 (20130101) G06F 12/1408 (20130101) G06F 21/72 (20130101) G06F 21/123 (20130101) G06F 21/575 (20130101) G06F 2212/1052 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/007 (20130101) H04L 9/0825 (20130101) Original (OR) Class
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10237766 — Estimation of available user data rate in a communications channel

US 10237766	Hughes et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	RAYTHEON COMPANY (Waltham, Massachusetts)
ASSIGNEE(S)	RAYTHEON COMPANY (Waltham, Massachusetts)
INVENTOR(S)	Timothy J. Hughes (San Diego, California); Deanna K. Harden (Fontana, California)
ABSTRACT	According to an aspect, a method for estimating available user data rate in a communications channel is provided. Node weight selection parameters are monitored by a resource manager executing on a node in communication with neighbor nodes. Neighbor node weight selection parameters are analyzed by the node. The node determines whether a change to a node weight or a neighbor node weight is needed to balance the available user data rate. The available user data rate is estimated for the node and the node weight is predictively adjusted as needed. The available user data rate is estimated for one or more of the neighbor nodes and an estimate of the neighbor node weight is generated as needed. A scheduler for the communications channel is updated based on the node weight and the estimate of the neighbor node weight.
FILED	Thursday, September 11, 2014
APPL NO	14/483215
ART UNIT	2415 — Multiplex and VoIP
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 41/147 (20130101) H04L 43/0894 (20130101) Wireless Communication Networks H04W 24/08 (20130101) Original (OR) Class H04W 28/22 (20130101)
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Department of Energy (DOE)

10231460 — Insecticidal proteins and methods for their use

US 10231460	Gruver et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	PIONEER HI-BRED INTERNATIONAL, INC. (Johnston, Iowa)
ASSIGNEE(S)	PIONEER HI-BRED INTERNATIONAL, INC. (, Iowa)
INVENTOR(S)	Steven Gruver (Pacifica, California); Heather Kozy (Walnut Creek, California); Jessica O'Rear (Redwood City, California); Barbara Rosen (Mountain View, California); Ute Schellenberger (Palo Alto, California); Jun-Zhi Wei (Palo Alto, California); Weiping Xie (East Palo Alto, California); Xiaohong Zhong (San Leandro, California); Genhai Zhu (San Jose, California)
ABSTRACT	Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
FILED	Thursday, January 07, 2016
APPL NO	15/543689
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/46 (20130101) A01N 63/02 (20130101) Original (OR) Class Peptides C07K 14/21 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8286 (20130101) Technologies for Adaptation to Climate Change Y02A 40/162 (20180101)
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10231707 — Ultrasound waveform tomography with wave-energy-based preconditioning

US 10231707	Huang et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Congressionally Directed Medical Research Programs (CDMRP) Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Lianjie Huang (Los Alamos, New Mexico); Zhigang Zhang (Los Alamos, New Mexico)
ABSTRACT	Synthetic-aperture ultrasound tomography systems and methods using scanning arrays and algorithms configured to simultaneously acquire ultrasound transmission and reflection data, and process the data using ultrasound waveform tomography with a wave-energy-based preconditioning method for improved ultrasound tomography imaging.
FILED	Thursday, July 24, 2014
APPL NO	14/339759
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0073 (20130101) A61B 5/7275 (20130101) A61B 8/13 (20130101) A61B 8/14 (20130101) A61B 8/15 (20130101) A61B 8/085 (20130101) A61B 8/145 (20130101) A61B 8/406 (20130101) A61B 8/483 (20130101) A61B 8/0825 (20130101) A61B 8/4477 (20130101) A61B 8/4488 (20130101) A61B 8/4494 (20130101) A61B 8/5207 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/8915 (20130101) G01S 15/8929 (20130101) G01S 15/8997 (20130101) Image Data Processing or Generation, in General G06T 5/001 (20130101) G06T 11/005 (20130101)
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10232007 — High molecular weight polysaccharide that binds and inhibits virus

US 10232007	Konowalchuk et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	World Force Technologies, LLC (Newport, Oregon)
ASSIGNEE(S)	WORLD FORCE TECHNOLOGIES, LLC (Newport, Oregon)
INVENTOR(S)	Thomas W. Konowalchuk (Newport, Oregon); Jack Konowalchuk (Newport, Oregon)
ABSTRACT	This invention provides a high molecular weight polysaccharide capable of binding to and inhibiting virus and related pharmaceutical formulations and methods of inhibiting viral infectivity and/or pathogenicity, as well as immunogenic compositions. The invention further includes methods of inhibiting the growth of cancer cells and of ameliorating a symptom of aging. Additionally, the invention provides methods of detecting and/or quantifying and/or isolating viruses.
FILED	Wednesday, June 14, 2017
APPL NO	15/623331
ART UNIT	1621 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0095 (20130101) A61K 31/353 (20130101) A61K 31/353 (20130101) A61K 31/715 (20130101) A61K 31/715 (20130101) A61K 36/87 (20130101) Original (OR) Class A61K 2300/00 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101)
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10232034 — Compositions comprising CH505 envelopes, and trimers

US 10232034	Haynes et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Duke University (Durham, North Carolina); Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	DUKE UNIVERSITY (Durham, North Carolina); LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Barton F. Haynes (Durham, North Carolina); Hua-Xin Liao (Durham, North Carolina); Bette T. Korber (Los Alamos, New Mexico); Peter T. Hraber (Los Alamos, New Mexico)
ABSTRACT	In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
FILED	Friday, September 25, 2015
APPL NO	15/513539
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4706 (20130101) A61K 39/12 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 47/4833 (20130101) A61K 47/48276 (20130101) A61K 47/48338 (20130101) A61K 47/48815 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) A61K 2039/627 (20130101) A61K 2039/6018 (20130101) Peptides C07K 14/70578 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16134 (20130101)
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10232344 — Solid sorbent materials for acid-gas separation

US 10232344	Soukri et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	Research Triangle Institute (Research Triangle Park, North Carolina)
ASSIGNEE(S)	Research Triangle Institute (Research Triangle Park, North Carolina)
INVENTOR(S)	Mustapha Soukri (Cary, North Carolina); Luke Coleman (Durham, North Carolina); Marty Lail (Raleigh, North Carolina)
ABSTRACT	Solid sorbent materials have been prepared by combining polyethyleneimine (PEI) with silica precursors. The solid sorbent materials can be used, for example, for acid gas separation, gas purification, and water purification applications. Advantageously, such materials can be water stable and the capacity of such solid sorbent materials does not diminish substantially after repeated use and regeneration.
FILED	Tuesday, July 14, 2015
APPL NO	15/326214
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Separation B01D 53/02 (20130101) B01D 2253/25 (20130101) B01D 2253/106 (20130101) B01D 2253/202 (20130101) B01D 2256/22 (20130101) B01D 2257/504 (20130101) B01D 2258/0283 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) B01J 20/262 (20130101) Original (OR) Class B01J 20/3085 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0206 (20130101) C08G 73/0213 (20130101) Capture, Storage, Sequestration or Disposal of Greenhouse Gases [GHG] Y02C 10/08 (20130101)
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10233087 — Highly crystalline 3D graphene

US 10233087	Worsley et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California); The Regents of the University of California (Oakland, California)
INVENTOR(S)	Marcus A. Worsley (Hayward, California); Leta Woo (Atlanta, Georgia); William Mickelson (Albany, California); Alex Zettl (Kensington, California)
ABSTRACT	Disclosed here is a composition comprising at least one graphene aerogel comprising a three-dimensional structure of graphene sheets, wherein the graphene sheets are covalently interconnected, and wherein the graphene aerogel is highly crystalline. Also described is a method for making a graphene aerogel, comprising preparing a mixture comprising a graphene oxide suspension and at least one catalyst; curing the reaction mixture to produce a wet gel; drying the wet gel to produce a dry gel; and pyrolyzing the dry gel at a temperature of 1500-3500° C. to produce the graphene aerogel.
FILED	Thursday, August 06, 2015
APPL NO	14/820411
ART UNIT	1783 — Miscellaneous Articles, Stock Material
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 32/182 (20170801) C01B 32/184 (20170801) Original (OR) Class C01B 2204/22 (20130101) C01B 2204/32 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2006/10 (20130101) C01P 2006/12 (20130101) C01P 2006/14 (20130101) C01P 2006/40 (20130101)
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10233098 — Nanoporous graphene membrane for desalination of salt water

US 10233098	Mahurin et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee); New Mexico State University (Las Cruces, New Mexico)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee); New Mexico State University (Las Cruces, New Mexico)
INVENTOR(S)	Shannon Mark Mahurin (Lenoir City, Tennessee); Ivan Vlassiouk (Oak Ridge, Tennessee); Sheng Dai (Knoxville, Tennessee); Sumedh Pradeep Surwade (Greenville, Delaware); Raymond R. Unocic (Knoxville, Tennessee); Sergei Smirnov (Las Cruces, New Mexico)
ABSTRACT	A method for the desalination of water, the method comprising flowing salt water through a free-standing single-layer membrane of nanoporous graphene having a first planar side that makes contact with the salt water and an opposing second planar side from which desalinated water exits, wherein said membrane contains nanopores having a size of up to 1 nm, along with a substantial absence of pores above 1 nm in size, wherein said nanopores up to 1 nm in size have pore edges passivated with silicon, wherein salt ions in said salt water are blocked from passing through said membrane while water in said salt water passes through said membrane to result in desalinated water exiting said membrane.
FILED	Thursday, January 14, 2016
APPL NO	14/995528
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 61/362 (20130101) B01D 63/087 (20130101) B01D 69/10 (20130101) B01D 71/021 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/442 (20130101) Original (OR) Class C02F 1/448 (20130101) C02F 2101/10 (20130101) C02F 2103/08 (20130101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 10/37 (20150501)
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10233292 — Renewable aromatics from lignocellulosic lignin

US 10233292	Singh et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	Sandia Corporation (Livermore, California)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Seema Singh (Fremont, California); Patanjali Varanasi (Fremont, California); Blake Simmons (San Francisco, California)
ABSTRACT	The present invention provides novel and improved processes for treating a lignocellulosic biomass or technical lignin using ionic liquids to obtain lignin breakdown products.
FILED	Monday, December 09, 2013
APPL NO	14/650506
ART UNIT	1767 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Compounds of Unknown Constitution C07G 1/00 (20130101) Derivatives of Natural Macromolecular Compounds C08H 6/00 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 97/005 (20130101) Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor D21C 3/20 (20130101) D21C 11/0007 (20130101)
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10233431 — Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases

US 10233431	Yuzawa et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Satoshi Yuzawa (El Cerrito, California); Leonard Katz (Oakland, California); Jay D. Keasling (Berkeley, California)
ABSTRACT	The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.
FILED	Thursday, February 26, 2015
APPL NO	14/633076
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/36 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/16 (20130101) C12N 9/1029 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) C12P 7/42 (20130101) Enzymes C12Y 101/01001 (20130101) C12Y 203/01 (20130101) C12Y 203/01041 (20130101) C12Y 301/02001 (20130101)
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10233457 — Inhibition of a xylosyltransferase to improve saccharification efficiency

US 10233457	Chiniquy et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Dawn Chiniquy (Berkeley, California); Pamela Ronald (Davis, California); Henrik Vibe Scheller (Millbrae, California)
ABSTRACT	The invention provides compositions and methods for inhibiting the expression of the gene XAX1 in grass plants. Plants with inhibited expression of XAX1 have use, e.g., in biofuel production by increasing the amount of soluble sugar that can be extracted from the plant.
FILED	Monday, July 29, 2013
APPL NO	13/953642
ART UNIT	1663 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8246 (20130101) Original (OR) Class
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10233458 — Carbon fixation systems in plants and algae

US 10233458	Sayre et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E) Office of Science (DOE-SC) Basic Energy Sciences (BES) Energy Frontier Research Centers (EFRC) Center for Advanced Biofuel Systems (CABS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Emerging Frontiers (EF)
APPLICANT(S)	NMC, INC. (Los Alamos, New Mexico)
ASSIGNEE(S)	NMC, INC. (Los Alamos, New Mexico)
INVENTOR(S)	Richard Thomas Sayre (Los Alamos, New Mexico); Somya S. Subramanian (Los Alamos, New Mexico); Natalia Friedland (Los Alamos, New Mexico)
ABSTRACT	Provided are methods for elevating cyclic electron transfer activity, improving carbon concentration, and enhancing carbon fixation in C3 and C4 plants, and algae, and producing biomass or other products from C3 or C4 plants, and algae, selected from among, for example, starches, oils, fatty acids, lipids, cellulose or other carbohydrates, alcohols, sugars, nutraceuticals, pharmaceuticals, fragrance and flavoring compounds, and organic acids, as well as transgenic plants produced thereby. These methods and transgenic plants and algae encompass the expression, or overexpression, of various combinations of genes that improve carbon concentrating systems in plants and algae, such as bicarbonate transport proteins, carbonic anhydrase, light driven proton pump, cyclic electron flow regulators, etc.
FILED	Friday, January 20, 2017
APPL NO	15/411854
ART UNIT	1663 — Plants
CURRENT CPC	Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) C12N 15/8243 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) Original (OR) Class C12N 2800/22 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 1/00 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101)
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10233473 — Cellulolytic enzyme compositions and uses thereof

US 10233473	Shasky et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Novozymes, Inc. (Davis, California)
ASSIGNEE(S)	Novozymes, Inc. (Davis, California)
INVENTOR(S)	Jeffrey Shasky (Davis, California); Suchindra Maiyuran (Gold River, California); Amanda Fischer (Davis, California)
ABSTRACT	The present invention relates to recombinant filamentous fungal host cells producing cellulolytic enzyme compositions and methods of producing and using the compositions.
FILED	Wednesday, September 05, 2018
APPL NO	16/122173
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/38 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2437 (20130101) C12N 9/2445 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) C12P 19/14 (20130101) Original (OR) Class Enzymes C12Y 302/01004 (20130101) C12Y 302/01008 (20130101) C12Y 302/01021 (20130101) C12Y 302/01037 (20130101) C12Y 302/01091 (20130101) C12Y 302/01176 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/16 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/52 (20151101)
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10233566 — Continuous single crystal growth of graphene

US 10233566	List, III et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Frederick Alyious List, III (Andersonville, Tennessee); Yijing Y. Stehle (Oak Ridge, Tennessee); Ivan V. Vlassiouk (Oak Ridge, Tennessee); Sergei N. Smirnov (Las Cruces, New Mexico)
ABSTRACT	Systems and methods for synthesizing continuous single crystal graphene are provided. A catalytic substrate is drawn through a chemical vapor deposition chamber in a first lengthwise direction while flowing a hydrogen gas through the chemical vapor deposition chamber in the same lengthwise direction. A hydrocarbon precursor gas is supplied directly above a surface of the catalytic substrate. A high concentration gradient of the hydrocarbon precursor at the crystal growth front is generated to promote the growth of a continuous single crystal graphene film while suppressing the growth of seed domains ahead of the crystal growth front.
FILED	Thursday, December 29, 2016
APPL NO	15/393464
ART UNIT	1713 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) C23C 16/545 (20130101) C23C 16/45563 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/14 (20130101) C30B 25/025 (20130101) Original (OR) Class C30B 29/02 (20130101)
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10233843 — Compositions and methods for generating cavitation resistance

US 10233843	Taleyarkhan
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Rusi Taleyarkhan (Lafayette, Indiana)
ABSTRACT	A method for generating cavitation resistance in a liquid, a portion of which can be in contact with a surface is disclosed. The disclosed method can be carried out by pressure-treating the liquid, the liquid portion in contact with the surface, and/or the surface for a sufficient time to develop resistance to cavitation. The disclosed method can be carried out when the surface is made of a material having a surface roughness that is greater than the rc of the liquid. Suitable surfaces include borosilicate glass, drawn glass, copper, lead, steel, cast iron, metal alloys and concrete. The surfaces can be ship and boat propeller surfaces, the interior of fuel lines and fuel storage containers or any other surface where cavitation can occur.
FILED	Wednesday, March 12, 2014
APPL NO	14/776317
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Marine Propulsion or Steering B63H 1/18 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/222 (20130101) Original (OR) Class Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 2200/04 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 21/047 (20130101)
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10233850 — Supervisory control of a compression ignition engine

US 10233850	Roth et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	DELPHI TECHNOLOGIES IP LIMITED (St. Michael, Barbados)
ASSIGNEE(S)	DELPHI TECHNOLOGIES IP LIMITED (, Barbados)
INVENTOR(S)	Gregory T. Roth (Davison, Michigan); Gary C. Fulks (Fort Myers, Florida); Andrew Fedewa (Clarkston, Michigan); Xiaojian Yang (Lake Orion, Michigan); Donald V. Johnson (White Lake, Michigan)
ABSTRACT	A system for controlling the combustion behavior of an engine is provided. The engine is equipped with a plurality of control subsystems that influence combustion in the engine. The system includes a controller configured to receive a plurality of inputs, to determine a desired subsystem states to operate the engine, and to determine a target value for each of a plurality of control parameters, wherein the target values for one or more control parameters depends on the values of the plurality of inputs. The controller is further configured to communicate the target values of control parameters to the control subsystems.
FILED	Wednesday, October 14, 2015
APPL NO	14/882821
ART UNIT	3748 — Printing/Measuring and Testing
CURRENT CPC	Internal-combustion Piston Engines; Combustion Engines in General F02B 3/10 (20130101) F02B 17/005 (20130101) Controlling Combustion Engines F02D 11/105 (20130101) F02D 35/02 (20130101) Original (OR) Class F02D 35/023 (20130101) F02D 41/0002 (20130101) F02D 41/0007 (20130101) F02D 41/008 (20130101) F02D 41/30 (20130101) F02D 2041/3052 (20130101)
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10234172 — Localized solar collectors

US 10234172	Ni et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	George Ni (Ann Arbor, Michigan); Gang Chen (Carlisle, Massachusetts); Svetlana V. Boriskina (Winchester, Massachusetts); Thomas Alan Cooper (Boston, Massachusetts)
ABSTRACT	A localized heating structure includes a spectrally-selective solar absorber, that absorbs incident solar radiation and reflects at wavelengths longer than 2 μm, with an underlying heat-spreading layer having a thermal conductivity equal to or greater than 50 W/(mK), a thermally insulating layer, adjacent to the spectrally-selective solar absorber, having a thermal conductivity of less than 0.1 W/(mK), one or more evaporation openings through the spectrally-selective solar absorber and the thermally insulating layer, and an evaporation wick, disposed in one or more of the evaporation openings in the thermally insulating layer, that contacts liquid and allows the liquid to be transported from a location beneath the thermally insulating layer through to the spectrally-selective solar absorber in order to generate vapor from the liquid. The thermally insulating layer is configured to have a density less than the liquid so that the localized heating structure is able to float on the liquid.
FILED	Monday, October 03, 2016
APPL NO	15/283914
ART UNIT	1788 — Miscellaneous Articles, Stock Material
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/18 (20130101) B32B 5/32 (20130101) B32B 2266/06 (20130101) Compositions of Macromolecular Compounds C08L 83/02 (20130101) Methods of Steam Generation; Steam Boilers F22B 1/006 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 10/17 (20180501) F24S 10/80 (20180501) F24S 20/25 (20180501) F24S 20/50 (20180501) Original (OR) Class F24S 70/10 (20180501) F24S 80/56 (20180501) F24S 80/65 (20180501) F24S 90/00 (20180501) F24S 2080/014 (20180501) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/44 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49826 (20150115) Y10T 428/249967 (20150401) Y10T 428/249969 (20150401)
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10234376 — Non-contact monitoring of biofilms and corrosion on submerged surfaces with electrochemical impedance spectroscopy

US 10234376	Turick et al.
FUNDED BY	Department of Energy (DOE) Office of Environmental Management (DOE-EM) Savannah River National Laboratory (SRNL) Federally Funded Research and Development Center (FFRDC) Operated by Savannah River Nuclear Solutions, LLC (SRNS) at Aiken, SC
APPLICANT(S)	Savannah River Nuclear Solutions, LLC (Aiken, South Carolina)
ASSIGNEE(S)	SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC (Aiken, South Carolina)
INVENTOR(S)	Charles E. Turick (Aiken, South Carolina); Charles E. Milliken (Evans, Georgia); Hector Colon-Mercado (Aiken, South Carolina); Scott D. Greenway (Aiken, South Carolina)
ABSTRACT	Systems and methods for monitoring microorganisms on a surface are provided. In particular, a flat, patterned sensing electrode can be positioned proximate a surface in non-contact relationship with the surface. The sensing electrode can include a working electrode and a counter electrode. The surface and the sensing electrode can be submerged in an aqueous medium. An alternating current signal can be applied at the working electrode. The signal can propagate through the aqueous medium and can be measured at the counter electrode. The presence of microorganisms on the surface can cause changes in the signal as the signal propagates through the aqueous medium. Such changes in the signal can be used to determine impedance parameters, which can correspond to microbial characteristics associated with the surface. For instance, the microbial characteristics can be associated with a biofilm, corrosion and/or bio-corrosion on the surface.
FILED	Tuesday, May 12, 2015
APPL NO	14/710175
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 17/02 (20130101) G01N 17/04 (20130101) Original (OR) Class
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10234411 — System and method for the direct calorimetric measurement of laser absorptivity of materials

US 10234411	Rubenchik et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Alexander Rubenchik (Livermore, California); Ilya V. Golosker (Livermore, California); Mary M. LeBlanc (Livermore, California); Scott C. Mitchell (Tracy, California); Sheldon S. Wu (Pleasanton, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Alexander Rubenchik (Livermore, California); Ilya V. Golosker (Livermore, California); Mary M. LeBlanc (Livermore, California); Scott C. Mitchell (Tracy, California); Sheldon S. Wu (Pleasanton, California)
ABSTRACT	A method and system for calorimetrically measuring the temperature-dependent absorptivity of a homogeneous material dimensioned to be thin and flat with a predetermined uniform thickness and a predetermined porosity. The system includes a material holder adapted to support and thermally isolate the material to be measured, an irradiation source adapted to uniformly irradiate the material with a beam of electromagnetic radiation, and an irradiation source controller adapted to control the irradiation source to uniformly heat the material during a heating period, followed by a cooling period when the material is not irradiated. A thermal sensor measures temperature of the material during the heating and cooling periods, and a computing system first calculates temperature-dependent convective and radiative thermal losses of the material based on the measured temperature of the material during the cooling period when beam intensity is zero, followed by calculation of the temperature-dependent absorptivity of the material based on the temperature-dependent convective and radiative thermal losses determined from the cooling period.
FILED	Monday, July 18, 2016
APPL NO	15/213210
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 17/00 (20130101) G01K 17/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/20 (20130101) Original (OR) Class G01N 25/48 (20130101) G01N 25/486 (20130101) G01N 25/4846 (20130101) G01N 25/4853 (20130101)
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10234508 — Dynamic parameter estimation of generators

US 10234508	Miao et al.
FUNDED BY	Department of Energy (DOE) Office of Electricity (DOE-OE)
APPLICANT(S)	Zhixin Miao (Tampa, Florida); Lingling Fan (Tampa, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida)
INVENTOR(S)	Zhixin Miao (Tampa, Florida); Lingling Fan (Tampa, Florida)
ABSTRACT	Various examples are provided for parameter estimation of generators. In one example, among others, a method includes collecting data corresponding to a generator using a phasor management unit (PMU) and estimating dynamic parameters of the generator using extended Kalman filtering (EKF) and the collected PMU data. In another example, a system includes at least one application executable in a processing device that obtains operational data corresponding to a generator and estimates a dynamic parameter of the generator using EKF and the operational data. In another example, an EKF estimator includes a dynamics estimator configured to estimate a state variable of a generator, a geometry estimator configured to estimate phasor values associated with the generator, and a Kalman filter gain configured to determine a correction to the state variable.
FILED	Friday, August 16, 2013
APPL NO	13/968693
ART UNIT	2857 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 31/343 (20130101) Original (OR) Class
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10234571 — Radiation detector

US 10234571	Tornga et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Shawn Robert Tornga (Los Alamos, New Mexico); Markus Peter Hehlen (Los Alamos, North Carolina); Edward McKigney (Los Alamos, New Mexico); Nickolaus Smith (Los Alamos, New Mexico); Christopher Hamilton (Los Alamos, New Mexico); Daniel Tyler Wakeford (Los Alamos, New Mexico); Jillian Cathleen Adams (Los Alamos, New Mexico); Olivia Carol Trautschold (Los Alamos, New Mexico)
ABSTRACT	A radiation detector including a scintillator; a wavelength shifting portion to cause a wavelength shift in photons emitted by the scintillator; and a photodetector optically coupled to the scintillator to receive the wavelength shifted photons.
FILED	Tuesday, October 31, 2017
APPL NO	15/799929
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Nuclear or X-radiation G01T 1/2002 (20130101) Original (OR) Class G01T 1/2018 (20130101) G01T 1/2023 (20130101)
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10234575 — Apparatus for use in a directional-neutron detector, directional-neutron detectors and methods of use thereof

US 10234575	Febbraro et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Michael T. Febbraro (Knoxville, Tennessee); Kelly A. Chipps (Oak Ridge, Tennessee); Steven D. Pain (Oak Ridge, Tennessee); William A. Peters (Oak Ridge, Tennessee)
ABSTRACT	An apparatus for used in a directional-neutron detector is disclosed. The apparatus comprises a structure having a plurality of parallel active channels separated by inactive regions. The plurality of active channels is filled with scintillating material. The scintillating material is configured to emit light in response to neutron scattering. The scintillating material may be neutron-gamma discriminating. The scintillating material may be sealed in the plurality of active channels. The seal is disposed on respective ends of the plurality of active channels. Directional-neutron detectors are also disclosed having the structure.
FILED	Tuesday, July 25, 2017
APPL NO	15/659145
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Nuclear or X-radiation G01T 1/2907 (20130101) G01T 3/06 (20130101) Original (OR) Class
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10234576 — Method and system for calibrating gamma radiation flux levels in a solid state gamma radiation detection system

US 10234576	Marriott et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	VPI Engineering, Inc. (Draper, Utah)
ASSIGNEE(S)	VPI Engineering, Inc. (Draper, Utah)
INVENTOR(S)	Kevin Marriott (Herriman, Utah); Paul Hepworth (South Jordan, Utah); Jeremy Williams (South Jordan, Utah)
ABSTRACT	One aspect of the present disclosure comprises a method for calibrating a drive level of a non-radioactive calibration source. Another aspect of the present disclosure comprises a method for using a non-radioactive calibration source to verify correct operation of a radiation detector. Another aspect of the present disclosure comprises a radiation detection system that comprises a radiation detector and a non-radioactive calibration source that is used to verify correct operation of the radiation detector.
FILED	Friday, April 29, 2016
APPL NO	15/143205
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Nuclear or X-radiation G01T 1/40 (20130101) G01T 7/005 (20130101) Original (OR) Class
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10234632 — Connectors for multicore optical fibers and methods thereof

US 10234632	Keeler et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Gordon Arthur Keeler (Albuquerque, New Mexico); Darwin K. Serkland (Albuquerque, New Mexico); Kent M. Geib (Tijeras, New Mexico)
ABSTRACT	The present invention relates to optical coupling systems that employ a multicore optical fiber. The system can be employed with two multicore optical fibers or with a single multicore optical fiber for use with an optical device. In particular, the system includes connectors having a lens assembly configured to relay optical signals and a ferrule to position the lens assembly. Additional details for making and using such systems are described herein.
FILED	Tuesday, August 16, 2016
APPL NO	15/238518
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/32 (20130101) Original (OR) Class G02B 6/02042 (20130101) G02B 6/3834 (20130101) G02B 6/3853 (20130101) G02B 6/4204 (20130101) Transmission H04B 10/2581 (20130101)
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10235290 — Hot page selection in multi-level memory hierarchies

US 10235290	Blagodurov et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Advanced Micro Devices, Inc. (Sunnyvale, California)
ASSIGNEE(S)	Advanced Micro Devices, Inc. (Santa Clara, California)
INVENTOR(S)	Sergey Blagodurov (Bellevue, Washington); Gabriel H. Loh (Bellevue, Washington); Mitesh R. Meswani (Austin, Texas)
ABSTRACT	Systems, apparatuses, and methods for sorting memory pages in a multi-level heterogeneous memory architecture. The system may classify pages into a first “hot” category or a second “cold” category. The system may attempt to place the “hot” pages into the memory level(s) closest to the systems' processor cores. The system may track parameters associated with each page, with the parameters including number of accesses, types of accesses, power consumed per access, temperature, wearability, and/or other parameters. Based on these parameters, the system may generate a score for each page. Then, the system may compare the score of each page to a threshold. If the score of a given page is greater than the threshold, the given page may be designated as “hot”. If the score of the given page is less than the threshold, the given page may be designated as “cold”.
FILED	Friday, June 26, 2015
APPL NO	14/752408
ART UNIT	2136 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 12/0811 (20130101) Original (OR) Class G06F 12/0897 (20130101) G06F 12/1027 (20130101) Climate Change Mitigation Technologies in Information and Communication Technologies [ICT] i.e Information and Communication Technologies Aiming at the Reduction of Their Own Energy Use Y02D 10/13 (20180101)
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10235614 — Communication device and method of making the same

US 10235614	Brocato
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Robert W. Brocato (Sandia Park, New Mexico)
ABSTRACT	A communication device for receiving an interrogation signal at a first carrier frequency and for transmitting a response signal at a second carrier frequency is disclosed. The interrogation signal comprises the first carrier frequency modulated at the second carrier frequency. The communication device includes a sensor coupled to a demodulator. The sensor receives a low frequency input used to further modulate the interrogation signal. The demodulator demodulates the low frequency input from the first carrier frequency to thereby generate the response signal comprising the second carrier frequency and the low frequency input. The demodulator preferably includes a pyroelectric demodulator, a piezoelectric demodulator, or a detector diode. The demodulator preferably has a frequency response less than the first carrier frequency but greater than the second carrier frequency.
FILED	Tuesday, November 01, 2016
APPL NO	15/340674
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10138 (20130101) G06K 19/0717 (20130101) Original (OR) Class G06K 19/0723 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/39 (20130101) H01L 41/187 (20130101) H01L 41/1871 (20130101) H01L 41/1873 (20130101) H01L 41/1876 (20130101) Demodulation or Transference of Modulation From One Carrier to Another H03D 1/00 (20130101) H03D 3/34 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 1/0007 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/06 (20130101)
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10236090 — Synthesizing radioisotopes using an energy recovery linac

US 10236090	Areti et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Thomas Jefferson National Accelerator Facility (TJNAF) Federally Funded Research and Development Center (FFRDC) Operated by Jefferson Science Associates, LLC (JSA) at Newport News, VA
APPLICANT(S)	Jefferson Science Associates, LLC (Newport News, Virginia)
ASSIGNEE(S)	JEFFERSON SCIENCE ASSOCIATES, LLC (Newport News, Virginia)
INVENTOR(S)	Hari Areti (Suffolk, Virginia); Andrew Kimber (Poquoson, Virginia); Andrew Hutton (Newport News, Virginia); David Douglas (Yorktown, Virginia); Rui Li (Yorktown, Virginia); Geoff Krafft (Newport News, Virginia)
ABSTRACT	An apparatus and method for the production of radioisotopes utilizing an energy recovery linac. The ERL system is composed of an electron beam source, multiple superconducting radio frequency cavities operating at 4.5 K, a thin radiator, a target material, and a beam dump. The accompanying method discloses the use of the ERL system to generate desired radioisotopes via target interaction with bremsstrahlung photons while allowing recovery of a substantial portion of the electron beam energy before the beam is extracted to the beam dump.
FILED	Thursday, July 04, 2013
APPL NO	13/935538
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Conversion of Chemical Elements; Radioactive Sources G21G 1/10 (20130101) G21G 1/12 (20130101) Original (OR) Class G21G 4/00 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/001 (20130101)
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10236460 — Photovoltaic cell enhancement through UVO treatment

US 10236460	So et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC) Basic Energy Sciences (BES)
APPLICANT(S)	Franky So (Gainesville, Florida); John R. Reynolds (Dunwoody, Georgia); Song Chen (Gainesville, Florida); Cephas Small (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainsville, Florida)
INVENTOR(S)	Franky So (Gainesville, Florida); John R. Reynolds (Dunwoody, Georgia); Song Chen (Gainesville, Florida); Cephas Small (Gainesville, Florida)
ABSTRACT	Photovoltaic cells, methods of fabricating photovoltaic cells, and methods of using photovoltaic cells to capture light energy are provided. A photovoltaic cell can include an electron transporting layer, a photoactive layer, and a hole transporting layer. The electron transporting layer can be ultraviolet ozone treated. The photovoltaic cell can have an inverted configuration.
FILED	Monday, July 23, 2012
APPL NO	13/555794
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/442 (20130101) Original (OR) Class H01L 51/4253 (20130101) H01L 2251/308 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101)
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10236500 — Lithium-ion cell having a high-capacity cathode

US 10236500	Zhamu et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Nanotek Instruments, Inc. (Dayton, Ohio)
ASSIGNEE(S)	Nanotek Instruments, Inc. (Dayton, Ohio)
INVENTOR(S)	Aruna Zhamu (Springboro, Ohio); Bor Z. Jang (Centerville, Ohio)
ABSTRACT	A method of operating a lithium-ion cell comprising (a) a cathode comprising a carbon or graphitic material having a surface area to capture and store lithium thereon; (b) an anode comprising an anode active material; (c) a porous separator disposed between the two electrodes; (d) an electrolyte in ionic contact with the two electrodes; and (e) a lithium source disposed in at least one of the two electrodes to obtain an open circuit voltage (OCV) from 0.5 volts to 2.8 volts when the cell is made; wherein the method comprises: (A) electrochemically forming the cell from the OCV to either a first lower voltage limit (LVL) or a first upper voltage limit (UVL), wherein the first LVL is no lower than 0.1 volts and the first UVL is no higher than 4.6 volts; and (B) cycling the cell between a second LVL and a second UVL.
FILED	Wednesday, April 19, 2017
APPL NO	15/491710
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/50 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/133 (20130101) H01M 4/386 (20130101) H01M 4/387 (20130101) H01M 4/0445 (20130101) H01M 4/483 (20130101) H01M 4/587 (20130101) H01M 4/1393 (20130101) Original (OR) Class H01M 10/44 (20130101) H01M 10/0525 (20130101) H01M 2004/028 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/7011 (20130101) Y02T 10/7022 (20130101)
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10236513 — Alkali-metal batteries with a dendrite-free anode interfacing an organic liquid electrolyte

US 10236513	Goodenough et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E) Office of Science (DOE-SC)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	John B. Goodenough (Austin, Texas); Leigang Xue (Austin, Texas); Byoungchul You (Austin, Texas)
ABSTRACT	A rechargeable battery cell has an organic-liquid electrolyte contacting a dendrite free alkali-metal anode. The alkali-metal anode may be a liquid at the operating temperature that is immobilized by absorption into a porous membrane. The alkali-metal anode may be a solid that wets a porous-membrane separator, where the contact between the solid alkali-metal anode and the liquid electrolyte is at micropores or nanopores in the porous-membrane separator. The use of a dendrite-free solid lithium cell was demonstrated in a symmetric cell with a porous cellulose-based separator membrane. A K⁺-ion rechargeable cell was demonstrated with a liquid K—Na alloy anode immobilized in a porous carbon membrane using an organic-liquid electrolyte with a Celgard® or glass-fiber separator.
FILED	Tuesday, March 07, 2017
APPL NO	15/452337
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Alloys C22C 24/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/1626 (20130101) H01M 4/40 (20130101) H01M 4/58 (20130101) H01M 4/76 (20130101) Original (OR) Class H01M 4/134 (20130101) H01M 4/381 (20130101) H01M 4/663 (20130101) H01M 10/052 (20130101) H01M 10/054 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2220/20 (20130101) H01M 2300/0037 (20130101)
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10236518 — High energy density redox flow device

US 10236518	Chiang et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	24M Technologies, Inc. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)	24M Technologies, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Yet-Ming Chiang (Weston, Massachusetts); William Craig Carter (Jamaica Plain, Massachusetts); Mihai Duduta (Somerville, Massachusetts); Pimpa Limthongkul (Boston, Massachusetts)
ABSTRACT	Redox flow devices are described including a positive electrode current collector, a negative electrode current collector, and an ion-permeable membrane separating said positive and negative current collectors, positioned and arranged to define a positive electroactive zone and a negative electroactive zone; wherein at least one of said positive and negative electroactive zone comprises a flowable semi-solid composition comprising ion storage compound particles capable of taking up or releasing said ions during operation of the cell, and wherein the ion storage compound particles have a polydisperse size distribution in which the finest particles present in at least 5 vol % of the total volume, is at least a factor of 5 smaller than the largest particles present in at least 5 vol % of the total volume.
FILED	Monday, August 31, 2015
APPL NO	14/840810
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 11/1879 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/20 (20130101) H01M 8/188 (20130101) H01M 8/0206 (20130101) H01M 8/0215 (20130101) H01M 8/0221 (20130101) H01M 8/0228 (20130101) H01M 8/0234 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/528 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/705 (20130101) Y02T 10/7005 (20130101) Y02T 10/7011 (20130101)
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10236526 — On-line monitoring of process/system

US 10236526	Gilliam et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	Calera Corporation (Moss Landing, California)
ASSIGNEE(S)	Calera Corporation (Moss Landing, California)
INVENTOR(S)	Ryan J. Gilliam (San Jose, California); Thomas A. Albrecht (Sunnyvale, California); Hong Zhao (Marina, California); Diego Martinez (Monterey, California); Rebecca L. King (Capitola, California)
ABSTRACT	Disclosed herein are methods and systems that relate to an on-line monitoring of a process/system by controlling rate of oxidation of metal ions at an anode in an anode electrolyte of an electrochemical process and controlling rate of reduction of the metal ions in a catalysis process to achieve steady state.
FILED	Friday, February 24, 2017
APPL NO	15/441704
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/04313 (20130101) H01M 8/04798 (20130101) H01M 8/04992 (20130101) Original (OR) Class
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10236920 — Signal transmitter and methods for transmitting signals from animals

US 10236920	Deng et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Z. Daniel Deng (Richland, Washington); Jun Lu (Richland, Washington); Huidong Li (Richland, Washington); Chuan Tian (Richland, Washington); Mitchell J. Myjak (Richland, Washington); Brian J. Bellgraph (Richland, Washington); Sam Cartmell (Richland, Washington); Jie Xiao (Richland, Washington)
ABSTRACT	Injectable transmitters are provided that can include a body with the body housing a power source and an oscillator, the injectable transmitter also including an antenna extending from the body, the body and antenna being of sufficient size to be injected through a 9 gauge needle. Radio frequency transmitters are provided that can include a body extending from a nose to a tail with the body housing a power source and RF signal generator components. The power source of the transmitter can define at least a portion of the nose of the body. The transmitters can have an antenna extending from the tail. Methods for attaching a radio frequency (RF) transmitter to an animal are provided. The methods can include providing an RF transmitter and providing an injection device having a needle of gauge of 9 or smaller; providing the RF transmitter into the injection device; and providing the RF transmitter through the 9 gauge or smaller needle and into the animal.
FILED	Thursday, March 31, 2016
APPL NO	15/087936
ART UNIT	2647 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 11/006 (20130101) A01K 11/008 (20130101) A01K 61/90 (20170101) A01K 99/00 (20130101) Diagnosis; Surgery; Identification A61B 5/1112 (20130101) A61B 5/6861 (20130101) A61B 2503/40 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 1/02 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/0723 (20130101) G06K 19/07762 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/5835 (20130101) H01M 2220/30 (20130101) Transmission H04B 1/034 (20130101) Original (OR) Class H04B 2001/3894 (20130101)
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10237335 — Managing cluster-level performance variability without a centralized controller

US 10237335	Piga
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	Advanced Micro Devices, Inc. (Sunnyvale, California)
ASSIGNEE(S)	Advanced Micro Devices, Inc. (Santa Clara, California)
INVENTOR(S)	Leonardo Piga (Austin, Texas)
ABSTRACT	Systems, apparatuses, and methods for managing cluster-level performance variability without a centralized controller are described. Each node of a multi-node cluster tracks a maximum and minimum progress across the plurality of nodes for a workload executed by the cluster. Each node also tracks its local progress on its current task. Each node also utilizes a comparison of the local progress to reported maximum and minimum progress across the cluster to identify a critical, or slow, node and whether to increase or reduce an amount of power allocated to the node. The nodes append information about the maximum and minimum progress to messages sent to other nodes to report their knowledge of maximum and minimum progress with other nodes. A node updates its local information if the node receives a message from another node with more up-to-date information about the state of progress across the cluster.
FILED	Wednesday, June 15, 2016
APPL NO	15/183625
ART UNIT	2457 — Computer Networks
CURRENT CPC	Electric Digital Data Processing G06F 9/00 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/10 (20130101) Original (OR) Class H04L 67/28 (20130101) H04L 67/1008 (20130101) H04L 67/1029 (20130101)
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10238009 — Coolant and ambient temperature control for chillerless liquid cooled data centers

US 10238009	Chainer et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Timothy J. Chainer (Putnam Valley, New York); Milnes P. David (Poughkeepsie, New York); Madhusudan K. Iyengar (Santa Clara, California); Pritish R. Parida (Stamford, Connecticut); Robert E. Simons (Poughkeepsie, New York)
ABSTRACT	Cooling control methods include measuring a temperature of at least one component of each of multiple nodes and finding a maximum component temperature across all such nodes, comparing the maximum component temperature to a first and second component threshold and comparing the air temperature to a first and second air threshold, and controlling a proportion of coolant flow and a coolant flow rate to the air-to-liquid heat exchanger and the nodes based on the comparisons.
FILED	Friday, January 22, 2016
APPL NO	15/004303
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 27/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 23/1932 (20130101) Electric Digital Data Processing G06F 1/206 (20130101) G06F 2200/201 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20836 (20130101) Original (OR) Class Climate Change Mitigation Technologies in Information and Communication Technologies [ICT] i.e Information and Communication Technologies Aiming at the Reduction of Their Own Energy Use Y02D 10/16 (20180101)
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National Science Foundation (NSF)

10232043 — Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and methods of using the same

US 10232043	Yen et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California); University of Southern California (Los Angeles, California)
INVENTOR(S)	Melanie A. Yen (Pasadena, California); Dennis A. Dougherty (Pasadena, California); Robert H. Grubbs (South Pasadena, California); Harry B. Gray (Pasadena, California); Robert H. Chow (Pasadena, California); Mark S. Humayun (Glendale, California); Mark E. Thompson (Anaheim, California); Lionel E. Cheruzel (San Jose, California)
ABSTRACT	Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.
FILED	Thursday, August 18, 2016
APPL NO	15/240997
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0079 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 41/00 (20130101) A61K 41/0057 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 5/0622 (20130101) A61N 2005/0626 (20130101) A61N 2005/0648 (20130101)
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10232345 — Aminoglycoside hydrogel microbeads and macroporous gels with chemical crosslink, method of preparation and use thereof

US 10232345	Rege et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S)	Kaushal Rege (Chandler, Arizona); Taraka Sai Pavan Grandhi (Tempe, Arizona); Thrimoorthy Potta (Phoenix, Arizona)
ABSTRACT	Methods and materials for the generation of amikacin antibiotic-derived microbeads, (FIG. 3). These beads may function as anion-exchange resins for use in pDNA purification as well as in situ capture of DNA from mammalian cells. New microresin and macroporous monolith based materials also are disclosed and may function for plasmid DNA binding and purification, mammalian whole cell genomic DNA extraction, and in-vitro cell culture.
FILED	Friday, February 12, 2016
APPL NO	15/547173
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Separation B01D 15/20 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) B01J 20/285 (20130101) Original (OR) Class B01J 20/28052 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/101 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2030/528 (20130101)
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10232368 — High-speed on demand droplet generation and single cell encapsulation driven by induced cavitation

US 10232368	Chiou et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Aeronautics and Space Administration (NASA) National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Pei-Yu E. Chiou (Los Angeles, California); Ting-Hsiang S. Wu (Culver City, California); Sung-Yong Park (Kent Vale, Singapore); Michael A. Teitell (Tarzana, California)
ABSTRACT	Methods and devices for the formation of droplets of a first fluid in a second fluid and the encapsulation of particles or cells within such droplets are disclosed. Impetus for droplet formation is provided by the creation of a transient bubble, which may be induced using a pulsed laser. Droplet volume and the frequency at which droplets are formed can be controlled by modulation of the pulsed laser. The disclosed methods and devices are particularly suitable for use in microfluidic devices.
FILED	Monday, November 02, 2015
APPL NO	14/930054
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/04 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 2200/0636 (20130101) B01L 2200/0647 (20130101) B01L 2200/0668 (20130101) B01L 2200/0673 (20130101) B01L 2300/0816 (20130101) B01L 2400/0403 (20130101) B01L 2400/0442 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/10 (20130101) G01N 21/64 (20130101) G01N 29/2418 (20130101) G01N 2015/1481 (20130101) G01N 2291/02433 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 11/13 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) Y10T 137/2496 (20150401)
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10232382 — Wireless SWNT sensor integrated with microfluidic system for various liquid sensing applications

US 10232382	Wang et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)	Northeastern University (Boston, Massachusetts)
INVENTOR(S)	Ming Wang (Stoneham, Massachusetts); Yu Liu (Boston, Massachusetts); Mehmet Remzi Dokmeci (Brookline, Massachusetts)
ABSTRACT	Sensors based on single-walled carbon nanotubes (SWNT) are integrated into a microfluidic system outfitted with data processing and wireless transmission capability. The sensors combine the sensitivity, specificity, and miniature size of SWNT-based nanosensors with the flexible fluid handling power of microfluidic “lab on a chip” analytical systems. Methods of integrating the SWNT-based sensor into a microfluidic system are compatible with the delicate nature of the SWNT sensor elements. The sensor devices are capable of continuously and autonomously monitoring and analyzing liquid samples in remote locations, and are applicable to real time water quality monitoring and monitoring of fluids in living systems and environments. The sensor devices and fabrication methods of the invention constitute a platform technology, because the devices can be designed to specifically detect a large number of distinct chemical agents based on the functionalization of the SWNT. The sensors can be combined into a multiplex format that detects desired combinations of chemical agents simultaneously.
FILED	Friday, December 18, 2015
APPL NO	14/974517
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/1473 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 2200/10 (20130101) B01L 2300/023 (20130101) B01L 2300/0645 (20130101) B01L 2300/0816 (20130101) B01L 2300/0896 (20130101) B01L 2400/049 (20130101) B01L 2400/0406 (20130101) B01L 2400/0439 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 5/005 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/02 (20130101) G01N 27/07 (20130101) G01N 27/4146 (20130101) G01N 33/18 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02104 (20130101)
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10233087 — Highly crystalline 3D graphene

US 10233087	Worsley et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California); The Regents of the University of California (Oakland, California)
INVENTOR(S)	Marcus A. Worsley (Hayward, California); Leta Woo (Atlanta, Georgia); William Mickelson (Albany, California); Alex Zettl (Kensington, California)
ABSTRACT	Disclosed here is a composition comprising at least one graphene aerogel comprising a three-dimensional structure of graphene sheets, wherein the graphene sheets are covalently interconnected, and wherein the graphene aerogel is highly crystalline. Also described is a method for making a graphene aerogel, comprising preparing a mixture comprising a graphene oxide suspension and at least one catalyst; curing the reaction mixture to produce a wet gel; drying the wet gel to produce a dry gel; and pyrolyzing the dry gel at a temperature of 1500-3500° C. to produce the graphene aerogel.
FILED	Thursday, August 06, 2015
APPL NO	14/820411
ART UNIT	1783 — Miscellaneous Articles, Stock Material
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 32/182 (20170801) C01B 32/184 (20170801) Original (OR) Class C01B 2204/22 (20130101) C01B 2204/32 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2006/10 (20130101) C01P 2006/12 (20130101) C01P 2006/14 (20130101) C01P 2006/40 (20130101)
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10233338 — Fired multilayer stacks for use in integrated circuits and solar cells

US 10233338	Hardin et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	PLANT PV, Inc. (Alameda, California)
ASSIGNEE(S)	PLANT PV, Inc. (Alameda, California)
INVENTOR(S)	Brian E. Hardin (San Carlos, California); Erik Sauar (Oslo, Norway); Dhea Suseno (Oakland, California); Jesse J. Hinricher (Pipestone, Minnesota); Jennifer Huang (Saratoga, California); Tom Yu-Tang Lin (Berkeley, California); Stephen T. Connor (San Francisco, California); Daniel J. Hellebusch (Oakland, California); Craig H. Peters (Belmont, California)
ABSTRACT	Intercalation pastes for use with semiconductor devices are disclosed. The pastes contain precious metal particles, intercalating particles, and an organic vehicle and can be used to improve the material properties of metal particle layers. Specific formulations have been developed to be screen-printed directly onto a dried metal particle layer and fired to make a fired multilayer stack. The fired multilayer stack can be tailored to create a solderable surface, high mechanical strength, and low contact resistance. In some embodiments, the fired multilayer stack can etch through a dielectric layer to improve adhesion to a substrate. Such pastes can be used to increase the efficiency of silicon solar cells, specifically multi- and mono-crystalline silicon back-surface field (BSF), and passivated emitter and rear contact (PERC) photovoltaic cells. Other applications include integrated circuits and more broadly, electronic devices.
FILED	Wednesday, November 23, 2016
APPL NO	15/360944
ART UNIT	1784 — Miscellaneous Articles, Stock Material
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 1/02 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0016 (20130101) B23K 35/025 (20130101) B23K 35/286 (20130101) B23K 35/3006 (20130101) B23K 35/3612 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 8/16 (20130101) C03C 8/18 (20130101) C03C 2205/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/24 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/049 (20141201) H01L 31/0201 (20130101) H01L 31/0203 (20130101) H01L 31/1804 (20130101) H01L 31/022425 (20130101) H01L 31/022433 (20130101) H01L 31/022441 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/34 (20141201)
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10233432 — Materials and methods for characterizing and using a 3-ketoacyl-acyl carrier protein (ACP) synthase III (KASIII) for production of bi-functional fatty acids

US 10233432	Garg et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa)
ASSIGNEE(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
INVENTOR(S)	Shivani Garg (Houston, Texas); Huanan Jin (Wuhan, China PRC); Marna Yandeau-Nelson (Ames, Iowa); Basil J. Nikolau (Ames, Iowa)
ABSTRACT	A mutant Bacillus subtilis, which does not express a functional KASIIIA and/or KASIIIB, and method of making; a mutant Rhodospirillum rubrum, which does not express a functional PhaC1, PhaC2, and/or PhaC3, and method of making; method of characterizing substrate specificity of KASIII; method of making mutant KASIII with altered substrate specificity and/or altered level of activity and nucleic acid, vector, host cell/organism, and mutant KASIII; an in vitro, high-throughput spectrophotometric method of assaying KASIII activity; and materials and methods for using KASIII for production of bi-functional fatty acids and the materials so produced.
FILED	Friday, September 29, 2017
APPL NO	15/721514
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1029 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6409 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/48 (20130101) Enzymes C12Y 203/0118 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/91057 (20130101)
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10233437 — Hypochlorite resistant cyanuric acid hydrolases and methods of use thereof

US 10233437	Wackett et al.
FUNDED BY	Department of Homeland Security (DHS) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); Lawrence P. Wackett (Minneapolis, Minnesota); Jennifer L. Seffernick (Minneapolis, Minnesota); Kelly Aukema (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Lawrence P. Wackett (Minneapolis, Minnesota); Jennifer L. Seffernick (Minneapolis, Minnesota); Kelly Aukema (Minneapolis, Minnesota)
ABSTRACT	The present invention relates to engineered cyanuric acid hydrolase enzymes that are resistant to hypochlorite and compositions and devices comprising such enzymes. The present invention also relates to methods of using these enzymes, compositions and devices for the treatment of a liquid, such as water.
FILED	Wednesday, March 02, 2016
APPL NO	15/554392
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/342 (20130101) C02F 2103/42 (20130101) C02F 2303/185 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/20 (20130101) C12N 9/86 (20130101) Original (OR) Class C12N 15/52 (20130101) Enzymes C12Y 305/02015 (20130101)
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10233458 — Carbon fixation systems in plants and algae

US 10233458	Sayre et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E) Office of Science (DOE-SC) Basic Energy Sciences (BES) Energy Frontier Research Centers (EFRC) Center for Advanced Biofuel Systems (CABS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Emerging Frontiers (EF)
APPLICANT(S)	NMC, INC. (Los Alamos, New Mexico)
ASSIGNEE(S)	NMC, INC. (Los Alamos, New Mexico)
INVENTOR(S)	Richard Thomas Sayre (Los Alamos, New Mexico); Somya S. Subramanian (Los Alamos, New Mexico); Natalia Friedland (Los Alamos, New Mexico)
ABSTRACT	Provided are methods for elevating cyclic electron transfer activity, improving carbon concentration, and enhancing carbon fixation in C3 and C4 plants, and algae, and producing biomass or other products from C3 or C4 plants, and algae, selected from among, for example, starches, oils, fatty acids, lipids, cellulose or other carbohydrates, alcohols, sugars, nutraceuticals, pharmaceuticals, fragrance and flavoring compounds, and organic acids, as well as transgenic plants produced thereby. These methods and transgenic plants and algae encompass the expression, or overexpression, of various combinations of genes that improve carbon concentrating systems in plants and algae, such as bicarbonate transport proteins, carbonic anhydrase, light driven proton pump, cyclic electron flow regulators, etc.
FILED	Friday, January 20, 2017
APPL NO	15/411854
ART UNIT	1663 — Plants
CURRENT CPC	Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) C12N 15/8243 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) Original (OR) Class C12N 2800/22 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 1/00 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101)
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10233544 — Growth of nitride films

US 10233544	Lu et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Board of Regents of the University of Nebraska (Lincoln, Nebraska)
ASSIGNEE(S)	NUtech Ventures (Lincoln, Nebraska)
INVENTOR(S)	Yongfeng Lu (Lincoln, Nebraska); Hossein Rabiee Golgir (Lincoln, Nebraska); Yunshen Zhou (Lincoln, Nebraska)
ABSTRACT	A gallium nitride thin film can be formed on a substrate at a low temperature (e.g., not higher than 600° C.) by applying a laser to resonantly excite molecules of a first precursor that contains nitrogen, in which the laser has a wavelength that is selected to match a vibration mode and/or a vibrational-rotational mode of the molecules of the first precursor. A second precursor is provided in which the excited first precursor and the second precursor react to form a nitride that is deposited on the substrate. For example, the second precursor may include gallium, and the nitride may be gallium nitride. Other nitride films can be produced in a similar manner.
FILED	Wednesday, May 18, 2016
APPL NO	15/158305
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Alloys C22C 11/06 (20130101) C22C 13/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/34 (20130101) C23C 16/303 (20130101) C23C 16/483 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02378 (20130101) H01L 21/02381 (20130101) H01L 21/02422 (20130101) H01L 21/02425 (20130101) H01L 29/2003 (20130101)
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10233559 — High rate electric field driven nanoelement assembly on an insulated surface

US 10233559	Sirman et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR) Nanoscale Science and Engineering Centers (NSF-NSEC)
APPLICANT(S)	Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)	Northeastern University (Boston, Massachusetts)
INVENTOR(S)	Asli Sirman (Boston, Massachusetts); Ahmed Busnaina (Needham, Massachusetts); Cihan Yilmaz (Boston, Massachusetts); Jun Huang (Malden, Massachusetts); Sivasubramanian Somu (Natick, Massachusetts)
ABSTRACT	A method for high rate assembly of nanoelements into two-dimensional void patterns on a non-conductive substrate surface utilizes an applied electric field to stabilize against forces resulting from pulling the substrate through the surface of a nanoelement suspension. The electric field contours emanating from a conductive layer in the substrate, covered by an insulating layer, are modified by a patterned photoresist layer, resulting in an increased driving force for nanoelements to migrate from a liquid suspension to voids on a patterned substrate having a non-conductive surface. The method can be used for the production of microscale and nanoscale circuits, sensors, and other electronic devices.
FILED	Monday, November 14, 2016
APPL NO	15/350636
ART UNIT	2847 — Electrical Circuits and Systems
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/4407 (20130101) C09D 5/4488 (20130101) C09D 125/06 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/04 (20130101) C25D 13/12 (20130101) C25D 13/20 (20130101) C25D 13/22 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0243 (20130101) H01L 21/0259 (20130101) H01L 21/02628 (20130101) H01L 29/0665 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/092 (20130101) H05K 1/0213 (20130101) H05K 1/0306 (20130101) H05K 3/1258 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/882 (20130101) Y10S 977/892 (20130101)
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10234347 — Rapid and wireless screening and health monitoring of materials and structures

US 10234347	Khizroev et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Sakhrat Khizroev (Miami, Florida); Rakesh Guduru (Miami, Florida); Dwayne McDaniel (Miramar, Florida)
ASSIGNEE(S)	The Florida International University Board of Trustees (Miami, Florida)
INVENTOR(S)	Sakhrat Khizroev (Miami, Florida); Rakesh Guduru (Miami, Florida); Dwayne McDaniel (Miramar, Florida)
ABSTRACT	Systems for screening and health monitoring of materials are provided. The system can include a material embedded with magneto-electric nanoparticles (MENs), a laser configured to direct incident laser light waves at a target area of the material, an optical filter disposed between the laser and the material, and an analyzer configured to detect the laser light reflected from the material.
FILED	Friday, December 22, 2017
APPL NO	15/852254
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/12 (20130101) G01L 1/247 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 27/288 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/0045 (20130101) H01F 1/344 (20130101) H01F 27/255 (20130101) H01F 27/2804 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/1871 (20130101)
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10234444 — System and method for nano-opto-mechanical-fluidic sensing of particles

US 10234444	Bahl et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Gaurav Bahl (Champaign, Illinois); Kewen Han (Champaign, Illinois)
ABSTRACT	A system and method includes nano opto-mechanical-fluidic resonators (nano-resonators), e.g., for identification of particles, e.g., single viruses and/or cells.
FILED	Wednesday, September 28, 2016
APPL NO	15/278633
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/10 (20130101) G01N 15/1056 (20130101) G01N 15/1436 (20130101) G01N 15/1459 (20130101) G01N 15/1484 (20130101) G01N 29/022 (20130101) G01N 33/487 (20130101) Original (OR) Class G01N 2015/0038 (20130101) G01N 2015/1043 (20130101) G01N 2015/1087 (20130101) G01N 2015/1454 (20130101)
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10235515 — Method and apparatus for on-demand isolated I/O channels for secure applications

US 10235515	Gligor et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
INVENTOR(S)	Virgil D Gligor (Pittsburgh, Pennsylvania); Zongwei Zhou (Mountain View, California); Miao Yu (Pittsburgh, Pennsylvania)
ABSTRACT	A computing platform for on-demand I/O channels, which enable secure application to dynamically connect to diverse peripheral devices of untrusted commodity OSes.
FILED	Friday, May 15, 2015
APPL NO	15/129548
ART UNIT	2438 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 9/45558 (20130101) G06F 21/44 (20130101) Original (OR) Class G06F 21/53 (20130101) G06F 21/57 (20130101) G06F 21/572 (20130101) G06F 2009/45579 (20130101) G06F 2009/45587 (20130101) G06F 2221/034 (20130101) G06F 2221/2141 (20130101) G06F 2221/2145 (20130101)
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10235517 — Robust device authentication

US 10235517	Lao et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Yingjie Lao (Minneapolis, Minnesota); Keshab K. Parhi (Minneapolis, Minnesota); Hyung-il Kim (Minneapolis, Minnesota)
ABSTRACT	An apparatus includes a finite state machine and a physical structure capable of providing a response to a challenge, the physical structure such that before the physical structure is ever provided with the challenge, the response to the challenge is unpredictable. The finite state machine moves from an initial state to an intermediate state due to receiving the response from the physical structure, and moves from the intermediate state to a final state due to receiving a key. The final state indicates whether the physical structure is a counterfeit physical structure.
FILED	Friday, May 13, 2016
APPL NO	15/154050
ART UNIT	2494 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/44 (20130101) Original (OR) Class G06F 21/73 (20130101) G06F 2221/2103 (20130101)
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10235600 — System and method for structured low-rank matrix factorization: optimality, algorithm, and applications to image processing

US 10235600	Vidal et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Deafness and Other Communication Disorders (NIDCD) National Science Foundation (NSF)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Rene Vidal (Fulton, Maryland); Benjamin Haeffele (Oakland, California); Eric D. Young (Baltimore, Maryland)
ABSTRACT	The present invention provides a system and method for structured low-rank matrix factorization of data. The system and method involve solving an optimization problem that is not convex, but theoretical results should that a rank-deficient local minimum gives a global minimum. The system and method also involve an optimization strategy that is highly parallelizable and can be performed using a highly reduced set of variables. The present invention can be used for many large scale problems, with examples in biomedical video segmentation and hyperspectral compressed recovery.
FILED	Wednesday, June 22, 2016
APPL NO	15/189270
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6247 (20130101) Original (OR) Class G06K 2009/4695 (20130101)
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10236122 — Boron nitride and method of producing boron nitride

US 10236122	Hosmane et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Narayan S. Hosmane (DeKalb, Illinois); Amartya Chakrabarti (Hoffman Estates, Illinois); Shena M. Peter (Rock Island, Illinois)
ASSIGNEE(S)	The Board of Trustees of Northern Illinois University (DeKalb, Illinois)
INVENTOR(S)	Narayan S. Hosmane (DeKalb, Illinois); Amartya Chakrabarti (Hoffman Estates, Illinois); Shena M. Peter (Rock Island, Illinois)
ABSTRACT	BN nanosheets are prepared by a method comprising heating to a temperature of at least 500° C., a mixture comprising: (1) an alkali borohydride, and (2) an ammonium salt. NaN₃may be included to increase the yield. No catalyst is required, and the product produced contains less than 0.1 atomic percent metal impurities.
FILED	Tuesday, November 18, 2014
APPL NO	15/100217
ART UNIT	2848 — Electrical Circuits and Systems
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/0646 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2004/24 (20130101) C01P 2006/40 (20130101) C01P 2006/80 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/10 (20130101) C30B 7/105 (20130101) C30B 29/60 (20130101) C30B 29/64 (20130101) C30B 29/403 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/08 (20130101) Original (OR) Class Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/734 (20130101) Y10S 977/842 (20130101)
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10236422 — Phosphors with narrow green emission

US 10236422	Nordsell et al.
FUNDED BY	Non-Profit Organization (NPO) Kentucky Science and Technology Corporation (KSTC) National Science Foundation (NSF) U.S. State Government Commonwealth of Kentucky Kentucky Cabinet for Economic Development (KY-CED)
APPLICANT(S)	EIE MATERIALS, INC. (Lexington, Kentucky)
ASSIGNEE(S)	EIE MATERIALS, INC. (Lexington, Kentucky)
INVENTOR(S)	Robert Nordsell (Lexington, Kentucky); Evan Thomas (Lexington, Kentucky); Yong Bok Go (Lexington, Kentucky); Kristen Baroudi (Lexington, Kentucky); Jonathan Melman (Lexington, Kentucky); Yuming Xie (Sugar Land, Texas)
ABSTRACT	Green emitting phosphors have the empirical composition RE_1−wA_wM_xE_y, where RE may be one or more Rare Earth elements (for example, Eu or Gd), A may be one or more elements selected from the group Mg, Ca, Sr, or Ba, M may be one or more elements selected from the group Al, Ga, B, In, Sc, Lu or Y, E may be one or more elements selected from the group S, Se, O, or Te, w is greater than or equal to zero, or greater than or equal to 0.01, or greater than or equal to 0.05, and less than or equal to about 0.8, 2≤x≤4, and 4≤y≤7.
FILED	Friday, May 25, 2018
APPL NO	15/990378
ART UNIT	2895 — Semiconductors/Memory
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7734 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/56 (20130101) H01L 33/502 (20130101) Original (OR) Class H01L 33/507 (20130101) H01L 2933/005 (20130101) H01L 2933/0041 (20130101)
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10236659 — Mode-locked lasers on silicon by palladium bonding and methods therefor

US 10236659	Preble et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	Stefan F. Preble (Pittsford, New York); Zihao Wang (Rochester, New York); Michael L. Fanto (Rome, New York)
ASSIGNEE(S)	Rochester Institute of Technology (Rochester, New York)
INVENTOR(S)	Stefan F. Preble (Pittsford, New York); Zihao Wang (Rochester, New York); Michael L. Fanto (Rome, New York)
ABSTRACT	A mode-locked laser on a silicon substrate and method for the production thereof by low temperature palladium bonding is disclosed.
FILED	Wednesday, April 04, 2018
APPL NO	15/944915
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/13 (20130101) G02B 2006/12061 (20130101) G02B 2006/12121 (20130101) G02B 2006/12123 (20130101) G02B 2006/12164 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/021 (20130101) H01S 5/0216 (20130101) Original (OR) Class H01S 5/0217 (20130101) H01S 5/0425 (20130101) H01S 5/0428 (20130101) H01S 5/0657 (20130101) H01S 5/3412 (20130101) H01S 5/34313 (20130101) H01S 2301/176 (20130101)
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National Aeronautics and Space Administration (NASA)

10231553 — Convertible bed

US 10231553	Gregory et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	Gregory Furniture Designs (High Point, North Carolina)
ASSIGNEE(S)	Scott Gregory and Associates, LLC (High Point, North Carolina); NASA Industrial Imp.E. Ex. De Manufacturados LTDA (Santa Catarina, Brazil)
INVENTOR(S)	Scott Gregory (High Point, North Carolina); Roberto Farinhaque (Sao Bento do Sul. SC, Brazil); Claudio Farinhaque (Sao Bento do Sul. SC, Brazil)
ABSTRACT	A bed convertible between a sofa configuration and a bed configuration. The bed includes a stationary bed support assembly having a stationary bed frame, a back rail, a front rail, and a plurality of slats adapted to support a mattress and a movable bed support assembly having a movable bed frame, a back rail, a front rail and a plurality of slats adapted to support a mattress. In one embodiment, a storage compartment is located underneath the stationary bed support assembly and the movable bed support assembly. Also, a backrest may be attached to the back rail of the stationary bed support assembly, whereby the backrest is adapted to support a user's back when the bed is in the sofa configuration.
FILED	Thursday, September 14, 2017
APPL NO	15/704862
ART UNIT	3673 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Chairs; Sofas; Beds A47C 17/22 (20130101) Original (OR) Class A47C 17/32 (20130101) A47C 19/025 (20130101) A47C 19/205 (20130101)
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10232016 — Methods for treating congestive heart failure

US 10232016	Marchionni et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Aeronautics and Space Administration (NASA)
APPLICANT(S)	Acorda Therapeutics, Inc. (Ardsley, New York); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Acorda Therapeutics, Inc. (Ardsley, New York); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S)	Mark Marchionni (Arlington, Massachusetts); Ralph Kelly (Chestnut Hill, Massachusetts); Beverly Lorell (Brookline, Massachusetts); Douglas B. Sawyer (Portland, Maine)
ABSTRACT	The invention features methods of treating or preventing congestive heart failure by administering a polypeptide containing an epidermal growth factor-like domain encoded by a neuregulin gene.
FILED	Thursday, September 03, 2015
APPL NO	14/844475
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1883 (20130101) Original (OR) Class A61K 39/395 (20130101) A61K 39/395 (20130101) A61K 2300/00 (20130101)
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10232368 — High-speed on demand droplet generation and single cell encapsulation driven by induced cavitation

US 10232368	Chiou et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Aeronautics and Space Administration (NASA) National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Pei-Yu E. Chiou (Los Angeles, California); Ting-Hsiang S. Wu (Culver City, California); Sung-Yong Park (Kent Vale, Singapore); Michael A. Teitell (Tarzana, California)
ABSTRACT	Methods and devices for the formation of droplets of a first fluid in a second fluid and the encapsulation of particles or cells within such droplets are disclosed. Impetus for droplet formation is provided by the creation of a transient bubble, which may be induced using a pulsed laser. Droplet volume and the frequency at which droplets are formed can be controlled by modulation of the pulsed laser. The disclosed methods and devices are particularly suitable for use in microfluidic devices.
FILED	Monday, November 02, 2015
APPL NO	14/930054
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/04 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 2200/0636 (20130101) B01L 2200/0647 (20130101) B01L 2200/0668 (20130101) B01L 2200/0673 (20130101) B01L 2300/0816 (20130101) B01L 2400/0403 (20130101) B01L 2400/0442 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/10 (20130101) G01N 21/64 (20130101) G01N 29/2418 (20130101) G01N 2015/1481 (20130101) G01N 2291/02433 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 11/13 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) Y10T 137/2496 (20150401)
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10233868 — Efficient, low pressure ratio propulsor for gas turbine engines

US 10233868	Gallagher et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Edward J. Gallagher (West Hartford, Connecticut); Byron R. Monzon (Cromwell, Connecticut)
ABSTRACT	A gas turbine engine includes a gear assembly, a bypass flow passage, and a core flow passage. The bypass flow passage includes an inlet. A fan is arranged at the inlet of the bypass flow passage. A first shaft and a second shaft are mounted for rotation about an engine central longitudinal axis. A first turbine is coupled with the first shaft such that rotation of the first turbine is configured to drive the fan, through the first shaft and gear assembly, at a lower speed than the first shaft. The fan includes a hub and a row of fan blades that extend from the hub. The row includes 12 (N) of the fan blades, a solidity value (R) that is from 1.0 to 1.2, and a ratio of N/R that is from 10.0 to 12.0.
FILED	Wednesday, August 31, 2016
APPL NO	15/252811
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 17/14 (20130101) Jet-propulsion Plants F02K 1/06 (20130101) F02K 3/06 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/327 (20130101) F05D 2260/4031 (20130101)
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10236166 — Lenslet array based integral field spectrograph and data processing

US 10236166	Gong et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America, as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Qian Gong (Columbia, Maryland); David A. Content (Bowie, Maryland); Michael W. McElwain (Bethesda, Maryland); Avram Max Mandell (Silver Spring, Maryland); Tyler D. Groff (Silver Spring, Maryland); Maxime J. Rizzo (Edgewater, Maryland)
ABSTRACT	A lenslet based integral field spectrograph (IFS) may have a design that makes better use of the detector pixels by placing adjacent spectra next to each other rather than staggering the spectra. Such a design maintains the main compactness and simplicity of prior lenslet array based IFSs, but improves the detector efficiency, which is rather low in conventional lenslet array based IFSs.
FILED	Friday, June 09, 2017
APPL NO	15/618359
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/009 (20130101) H01J 49/0018 (20130101) Original (OR) Class H01J 49/0022 (20130101)
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10236693 — Modular battery controller

US 10236693	Button et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	Robert Button (Westlake, Ohio); Marcelo C. Gonzalez (Macedonia, Ohio)
ASSIGNEE(S)	The United States of America as Represented by the Administrator of National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Robert Button (Westlake, Ohio); Marcelo C. Gonzalez (Macedonia, Ohio)
ABSTRACT	Some embodiments of the present invention describe a battery including a plurality of master-less controllers. Each controller is operatively connected to a corresponding cell in a string of cells, and each controller is configured to bypass a fraction of current around the corresponding cell when the corresponding cell has a greater charge than one or more other cells in the string of cells.
FILED	Monday, December 19, 2016
APPL NO	15/383093
ART UNIT	2859 — Printing/Measuring and Testing
CURRENT CPC	Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/007 (20130101) H02J 7/0016 (20130101) Original (OR) Class H02J 7/0021 (20130101)
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Department of Agriculture (USDA)

10231383 — Nematode resistant crops

US 10231383	Mitchum et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Melissa G. Mitchum (Columbia, Missouri); Amy Replogle (Columbia, Missouri); Jianying Wang (Columbia, Missouri); Xiaohong Wang (Washington, District of Columbia); Shiyan Chen (Ithaca, New York); Ping Lang (Ithaca, New York); Eric L. Davis (Raleigh, North Carolina); Thomas J. Baum (Ames, Iowa); Richard S. Hussey (Athens, Georgia)
ASSIGNEE(S)	The Curators of the University of Missouri (Columbia, Missouri); Cornell University (Ithaca, New York); North Carolina State University (Raleigh, North Carolina); Iowa State University Research Foundation, Inc. (Ames, Iowa); University of Georgia Research Foundation, Inc. (Athens, Georgia); The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S)	Melissa G. Mitchum (Columbia, Missouri); Amy Replogle (Columbia, Missouri); Jianying Wang (Columbia, Missouri); Xiaohong Wang (Washington, District of Columbia); Shiyan Chen (Ithaca, New York); Ping Lang (Ithaca, New York); Eric L. Davis (Raleigh, North Carolina); Thomas J. Baum (Ames, Iowa); Richard S. Hussey (Athens, Georgia)
ABSTRACT	Methods of inhibiting plant parasitic nematodes, methods of obtaining transgenic plants useful for inhibiting such nematodes, and transgenic plants that are resistant to plant parasitic nematodes through inhibition of plant nematode CLAVATA3/ESR (CLE) peptide receptor genes are provided. Methods for expressing genes at plant parasitic nematode feeding sites with plant nematode CLE peptide receptor gene promoters are also provided, along with nematode CLE peptide receptor gene promoters that are useful for expressing genes in nematode feeding sites as well as transgenic plants and nematode resistant transgenic plants comprising the promoters.
FILED	Wednesday, July 13, 2011
APPL NO	13/814591
ART UNIT	1662 — Plants
CURRENT CPC	Harvesting; Mowing A01D 91/00 (20130101) Original (OR) Class Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8285 (20130101) Technologies for Adaptation to Climate Change Y02A 40/164 (20180101)
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10232027 — Live attenuated Edwardsiella ictaluri vaccine and method of using the same

US 10232027	Karsi et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Attila Karsi (Starkville, Mississippi); Mark L. Lawrence (Starkville, Mississippi); Hossam Abdelhamed (Starkville, Mississippi)
ASSIGNEE(S)	MISSISSIPPI STATE UNIVERSITY (Mississippi State, Mississippi)
INVENTOR(S)	Attila Karsi (Starkville, Mississippi); Mark L. Lawrence (Starkville, Mississippi); Hossam Abdelhamed (Starkville, Mississippi)
ABSTRACT	A live attenuated Edwardsiella ictaluri bacterium lacking a viable gene encoding a functional evpB protein and a method of using the same to protect fish against infection from virulent Edwardsiella ictaluri. The methods and compositions for protecting fish against infection from virulent Edwardsiella ictaluri comprising administering to a fish a therapeutically effective amount of an attenuated Edwardsiella ictaluri bacterium lacking a viable gene encoding a functional EvpB protein. The bacterium may include an insertion and/or deletion mutation in the evpB gene. The fish include catfish, preferably catfish fingerling or a catfish fry. The composition may be delivered via immersion delivery, an injection delivery, an oral delivery, or combinations thereof.
FILED	Tuesday, September 06, 2016
APPL NO	15/257607
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/025 (20130101) Original (OR) Class A61K 2039/54 (20130101) A61K 2039/57 (20130101) A61K 2039/522 (20130101) A61K 2039/552 (20130101) Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/36 (20130101)
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10233209 — Inhibitors of the farnesoid x receptor and uses in medicine

US 10233209	Gonzalez et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS) Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	The United States of America, As represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia); The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Frank J. Gonzalez (Bethesda, Maryland); Changtao Jiang (Beijing, China PRC); Cen Xie (Rockville, Maryland); Andrew D. Patterson (State College, Pennsylvania); Fei Li (Rockville, Maryland); James B. Mitchell (Damascus, Maryland); Shantu Amin (Union City, New Jersey); Dhimant Desai (Mechanicsburg, Pennsylvania)
ABSTRACT	Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R¹, R², R⁴, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal.
FILED	Tuesday, December 06, 2016
APPL NO	15/371032
ART UNIT	1621 — Organic Chemistry
CURRENT CPC	Steroids C07J 9/005 (20130101) C07J 31/006 (20130101) C07J 41/0055 (20130101) C07J 41/0061 (20130101) Original (OR) Class C07J 41/0066 (20130101)
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10233482 — Micro-fluidic mixer and method of determining pathogen inactivation via antimicrobial solutions

US 10233482	Luo et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); University of Maryland (College Park, Maryland)
ASSIGNEE(S)	The United States of America, as represented by The Secretary of Agriculture (Washington, District of Columbia); University of Maryland (College Park, Maryland)
INVENTOR(S)	Yaguang Luo (Bethesda, Maryland); Boce Zhang (Olney, Maryland); Patricia D. Millner (Burtonsville, Maryland)
ABSTRACT	A sample of produce wash water containing an antimicrobial sanitizer fluid, and a reference pathogen fluid are both injected into a pathogen inactivation region of a micro-fluidic mixer. The produce wash water (i.e. sanitizer fluid/pathogen fluid mix) is directed through mixer elements in the pathogen inactivation region of the micro-fluidic mixer. In the sanitizer deactivation region, a sanitizer deactivation solution is added to the sanitizer fluid/pathogen fluid mix to produce a deactivated solution. The deactivated solution is evaluated for the presence of the pathogen and the characteristics of the sanitizer. In the preferred embodiment, the sanitizer comprises chlorine and the pathogen comprises E. coli bacteria.
FILED	Wednesday, September 09, 2015
APPL NO	14/849034
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 5/0619 (20130101) B01F 5/0647 (20130101) B01F 13/0059 (20130101) B01F 2005/0636 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/18 (20130101)
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Department of Commerce (DOC)

10232434 — Refining and casting apparatus and method

US 10232434	Forbes Jones et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Advanced Technology Program (NIST-ATP)
APPLICANT(S)	ATI Properties LLC (Albany, Oregon)
ASSIGNEE(S)	ATI PROPERTIES LLC (Albany, Oregon)
INVENTOR(S)	Robin M. Forbes Jones (Charlotte, North Carolina); Sterry A. Shaffer (Charlotte, North Carolina)
ABSTRACT	An apparatus for casting metals by a nucleated casting technique to create a preform, the apparatus including a mold having a base and a side wall where the base can be moved relative to the side wall to withdraw the preform as it is being created. In various circumstances, portions of a droplet spray created by an atomizing nozzle, i.e., overspray, may accumulate on a top surface of the side wall and prevent or inhibit the preform from being moved relative to the side wall. The atomizing nozzle can be oriented such that the droplet spray passes over the top of the side wall to remelt and remove at least a portion of the overspray that has accumulated thereon. The mold can be rotated such that the overspray formed on a region of or on the entire perimeter of the top surface can pass through the droplet spray and can be removed from the side wall.
FILED	Monday, October 27, 2014
APPL NO	14/524052
ART UNIT	3761 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 23/003 (20130101) Original (OR) Class
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10234309 — Photon momentum sensor

US 10234309	Artusio-Glimpse et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	The United States of America, as Represented by the Secretary of Commerce (Washington, District of Columbia)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Washington, District of Columbia)
INVENTOR(S)	Alexandra Artusio-Glimpse (Boulder, Colorado); John Lehman (Boulder, Colorado); Michelle Stephens (Boulder, Colorado); Nathan Tomlin (Boulder, Colorado); Paul Williams (Erie, Colorado); Ivan Ryger (Boulder, Colorado)
ABSTRACT	A photon momentum sensor includes: a reflector plate that includes: a central disk including a mirror; an annular member; a plurality of spring legs interposed between the central disk and the annular member, such that: the spring legs are interleaved; neighboring spring legs are spaced apart; and the spring legs individually are arranged in an Archimedean spiral that provides orthogonal motion of the central disk relative to the plane of the annular member; and a bias plate disposed opposing the reflector plate such that: the central disk of the reflector plate moves orthogonally to a plane of the bias plate in response to reflection of laser light, and the central disk and the bias plate are arranged spaced apart as a capacitive structure.
FILED	Monday, June 12, 2017
APPL NO	15/620746
ART UNIT	2878 — Optics
CURRENT CPC	Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/285 (20130101) Original (OR) Class
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10236433 — Thermal impedance amplifier

US 10236433	McCaughan et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	The United States of America, as Represented by the Secretary of Commerce (Washington, District of Columbia)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Washington, District of Columbia)
INVENTOR(S)	Adam McCaughan (Denver, Colorado); Varun Verma (Lafayette, Colorado); Sonia Buckley (Boulder, Colorado); Sae Woo Nam (Boulder, Colorado)
ABSTRACT	A thermal impedance amplifier includes: a resistive layer including: a resistance member; a first electrode in electrical communication with the resistance member; and a second electrode in electrical communication with the resistance member; a switch layer opposing the resistive layer and including: a switch member; a first switch electrode in electrical communication with the switch member; and a second switch electrode in electrical communication with the switch member, the switch member: switching from a first resistance to a second resistance in response to receiving phonons from the resistance member, being superconductive at the first resistance, and producing an amplified voltage in response to being at the second resistance; and a thermal conductor interposed between the resistance member and the switch member.
FILED	Tuesday, January 23, 2018
APPL NO	15/878010
ART UNIT	2826 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/437 (20130101) H01L 39/10 (20130101) Original (OR) Class H01L 39/16 (20130101) H01L 39/025 (20130101) H01L 39/045 (20130101) H01L 39/145 (20130101) H01L 39/2493 (20130101)
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Department of Homeland Security (DHS)

10233437 — Hypochlorite resistant cyanuric acid hydrolases and methods of use thereof

US 10233437	Wackett et al.
FUNDED BY	Department of Homeland Security (DHS) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); Lawrence P. Wackett (Minneapolis, Minnesota); Jennifer L. Seffernick (Minneapolis, Minnesota); Kelly Aukema (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Lawrence P. Wackett (Minneapolis, Minnesota); Jennifer L. Seffernick (Minneapolis, Minnesota); Kelly Aukema (Minneapolis, Minnesota)
ABSTRACT	The present invention relates to engineered cyanuric acid hydrolase enzymes that are resistant to hypochlorite and compositions and devices comprising such enzymes. The present invention also relates to methods of using these enzymes, compositions and devices for the treatment of a liquid, such as water.
FILED	Wednesday, March 02, 2016
APPL NO	15/554392
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/342 (20130101) C02F 2103/42 (20130101) C02F 2303/185 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/20 (20130101) C12N 9/86 (20130101) Original (OR) Class C12N 15/52 (20130101) Enzymes C12Y 305/02015 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10235908 — Tamper-proof electronic bolt-seal

US 10235908	Yazdi et al.
FUNDED BY	Department of Homeland Security (DHS) Science and Technology Directorate (DHS-ST)
APPLICANT(S)	Evigia Systems, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S)	Navid Yazdi (Ann Arbor, Michigan); William Kwolek (Manchester, Michigan)
ABSTRACT	A tamper-proof bolt-seal incorporating a unique identification tamper detection sensor that cannot be restored or duplicated after the bolt. The sensor employs a resistive sensor wire embedded in the bolt. The resistive sensor wire has a randomized length to enable a unique resistive value for that sensor. The resistive value of the sensor is combined with an electronic identification code to create the unique seal identification for the tamper detection sensor, therefore giving the bolt a seal identification that is unique and that cannot be restored or duplicated.
FILED	Monday, September 10, 2018
APPL NO	16/125843
ART UNIT	2689 — Signal Processing and Control Processing in Disk Drives
CURRENT CPC	Locks; Accessories Therefor; Handcuffs E05B 39/005 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 13/06 (20130101) Displaying; Advertising; Signs; Labels or Name-plates; Seals G09F 3/0317 (20130101) G09F 3/0329 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Department of Veterans Affairs (DVA)

10231692 — Abdominal statistics physiological monitoring system and methods

US 10231692	Spiegel et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
INVENTOR(S)	Brennan Spiegel (Los Angeles, California); William Kaiser (Los Angeles, California); Vincent Zegarski (Los Angeles, California); Digvijay Singh (Los Angeles, California)
ABSTRACT	An abdominal statistics system including a low profile rapidly deployable sensor element having an acoustic sensor and vibration actuator that can be conveniently attached to the abdomen of a patient. The system acquires acoustic signals as gastrointestinal (GI) sounds, processes these signals, and provides actionable data to patients and their providers.
FILED	Monday, July 03, 2017
APPL NO	15/641126
ART UNIT	2654 — Audio Signals
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/002 (20130101) A61B 5/0022 (20130101) A61B 5/4255 (20130101) A61B 5/6823 (20130101) A61B 7/04 (20130101) Original (OR) Class A61B 7/008 (20130101) Electric Digital Data Processing G06F 17/18 (20130101) G06F 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

10231736 — System and method for soft tissue gripping

US 10231736	Shah et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES OF AMERICA (Washington, District of Columbia)
INVENTOR(S)	Sameer B. Shah (San Diego, California); Johnathan L. Le (Fontana, California); Daniel Moskowitz (Los Osos, California); Fabian Ramirez (Modesto, California); Aileen Tran (West Covina, California); Nathan Delson (San Diego, California)
ABSTRACT	Systems and methods disclosed stimulate nerve growth by applying a tensile (axial pulling) load on a proximal stump of the nerve. This load may be imposed once, at the time of repair. This implementation may be advantageously employed to remove tension away from the repair site, for any number of soft tissues, e.g., nerves, ligaments, tendons, and so on. Alternately, for a larger gap, by progressively elongating a nerve through tensile stimulation, the nerve may regenerate and be fully functional, particularly if elongated at a proper rate. After sufficient regrowth, nerve ends may be reattached, resulting in more complete functional recovery. Two implementations, which have been embodied in prototype devices, also include particularly useful features, one of which uses a screw and clamp with slotted insert design, and the other of which enables the use of sutures or straps to secure the tissue to the clamp.
FILED	Monday, June 13, 2016
APPL NO	15/181287
ART UNIT	3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/11 (20130101) A61B 17/1128 (20130101) Original (OR) Class A61B 17/1146 (20130101) A61B 90/02 (20160201) A61B 2017/1103 (20130101) A61B 2017/1132 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/05 (20130101) A61N 1/0556 (20130101) A61N 1/0558 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Security Agency (NSA)

10235734 — Translation of artificial intelligence representations

US 10235734	Riabov et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Anton V. Riabov (Ann Arbor, Michigan); Shirin Sohrabi Araghi (Port Chester, New York); Octavian Udrea (Ossining, New York)
ABSTRACT	Techniques for translating graphical representations of domain knowledge are provided. In one example, a computer-implemented method comprises receiving, by a device operatively coupled to a processor, a graphical representation of domain knowledge. The graphical representation comprises information indicative of a central concept and at least one chain of events associated with the central concept. The computer-implemented method further comprises translating, by the device, the graphical representation into an artificial intelligence planning problem. The artificial intelligence planning problem is expressed in an artificial intelligence description language. The translating comprises parsing the graphical representation into groupings of terms. A first grouping of terms of the grouping of terms comprises an event from the at least one chain of events and a second grouping of terms of the grouping of terms comprises the information indicative of the central concept. The computer-implemented method also comprises validating, by the device, the artificial intelligence planning problem.
FILED	Friday, January 27, 2017
APPL NO	15/418418
ART UNIT	2616 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC	Electric Digital Data Processing G06F 15/18 (20130101) G06F 17/30277 (20130101) Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) Image Data Processing or Generation, in General G06T 1/20 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10235765 — Method of comparing a camera fingerprint and a query fingerprint

US 10235765	Charlton et al.
FUNDED BY	National Security Agency (NSA)
APPLICANT(S)	The United States of America as represented by the Director, National Security Agency (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by Director National Security Agency (Washington, District of Columbia)
INVENTOR(S)	Sarah T. Charlton (Frederick, Maryland); Katelyn J. Meixner (Columbia, Maryland)
ABSTRACT	The present invention discloses a method for comparing a camera fingerprint to a query fingerprint. An estimate of a camera fingerprint is obtained from a set of one or more images, and the query fingerprint is obtained from one or more images. Using these values, normalized cross-correlations values are determined for each possible alignment of the two fingerprints. Prior to calculating the noise floor, a set including the highest normalized cross-correlation values is identified. A universal noise floor is then calculated excluding this set from the noise floor calculation. The universal noise floor is utilized in calculating a correlation energy for each possible shift. The correlation energy values are then examined to determine whether the camera fingerprint and the query fingerprint match. A visualization tool may also be used to compare the camera fingerprint and the query fingerprint and determine whether the camera fingerprint and the query fingerprint match. The visualization tool may provide a plot utilizing surfaces or heat maps. The plots allow for a quick and easy analysis and determination as to whether the camera fingerprint and the query fingerprint match.
FILED	Thursday, September 29, 2016
APPL NO	15/279928
ART UNIT	2669 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/32 (20170101) Original (OR) Class G06T 7/37 (20170101)
VIEW PATENT	@ USPTO: Full Text PDF

Non-Profit Organization (NPO)

10236422 — Phosphors with narrow green emission

US 10236422	Nordsell et al.
FUNDED BY	Non-Profit Organization (NPO) Kentucky Science and Technology Corporation (KSTC) National Science Foundation (NSF) U.S. State Government Commonwealth of Kentucky Kentucky Cabinet for Economic Development (KY-CED)
APPLICANT(S)	EIE MATERIALS, INC. (Lexington, Kentucky)
ASSIGNEE(S)	EIE MATERIALS, INC. (Lexington, Kentucky)
INVENTOR(S)	Robert Nordsell (Lexington, Kentucky); Evan Thomas (Lexington, Kentucky); Yong Bok Go (Lexington, Kentucky); Kristen Baroudi (Lexington, Kentucky); Jonathan Melman (Lexington, Kentucky); Yuming Xie (Sugar Land, Texas)
ABSTRACT	Green emitting phosphors have the empirical composition RE_1−wA_wM_xE_y, where RE may be one or more Rare Earth elements (for example, Eu or Gd), A may be one or more elements selected from the group Mg, Ca, Sr, or Ba, M may be one or more elements selected from the group Al, Ga, B, In, Sc, Lu or Y, E may be one or more elements selected from the group S, Se, O, or Te, w is greater than or equal to zero, or greater than or equal to 0.01, or greater than or equal to 0.05, and less than or equal to about 0.8, 2≤x≤4, and 4≤y≤7.
FILED	Friday, May 25, 2018
APPL NO	15/990378
ART UNIT	2895 — Semiconductors/Memory
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7734 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/56 (20130101) H01L 33/502 (20130101) Original (OR) Class H01L 33/507 (20130101) H01L 2933/005 (20130101) H01L 2933/0041 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Small Business Administration (SBA)

10234701 — Waveguide array modulator for high performance systems

US 10234701	Morton et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Morton Photonics (West Friendship, Maryland)
ASSIGNEE(S)	Morton Photonics (West Friendship, Maryland)
INVENTOR(S)	Paul A. Morton (West Friendship, Maryland); Jacob Khurgin (Pikesville, Maryland)
ABSTRACT	In the Waveguide Array Modulator (WAM) a single electrical signal drives an array of waveguide optical modulators, creating multiple modulated output signals that can be combined to provide a higher output power than from a single waveguide based modulator, enabling a higher dynamic range system. Alternatively, using a WAM in which different waveguide optical modulators are designed for different dynamic ranges, e.g. one highly efficient modulator for low level signals and one low efficiency but linear modulator for high level signals, the WAM based system can provide a higher dynamic range than from a single waveguide based modulator. Various WAM based systems for different applications are included.
FILED	Wednesday, October 18, 2017
APPL NO	15/787008
ART UNIT	2883 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0121 (20130101) Original (OR) Class G02F 1/2257 (20130101) G02F 2001/212 (20130101) G02F 2201/02 (20130101) G02F 2201/18 (20130101) G02F 2203/58 (20130101) G02F 2203/70 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/38 (20130101) H03H 7/48 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

U.S. State Government

10236422 — Phosphors with narrow green emission

US 10236422	Nordsell et al.
FUNDED BY	Non-Profit Organization (NPO) Kentucky Science and Technology Corporation (KSTC) National Science Foundation (NSF) U.S. State Government Commonwealth of Kentucky Kentucky Cabinet for Economic Development (KY-CED)
APPLICANT(S)	EIE MATERIALS, INC. (Lexington, Kentucky)
ASSIGNEE(S)	EIE MATERIALS, INC. (Lexington, Kentucky)
INVENTOR(S)	Robert Nordsell (Lexington, Kentucky); Evan Thomas (Lexington, Kentucky); Yong Bok Go (Lexington, Kentucky); Kristen Baroudi (Lexington, Kentucky); Jonathan Melman (Lexington, Kentucky); Yuming Xie (Sugar Land, Texas)
ABSTRACT	Green emitting phosphors have the empirical composition RE_1−wA_wM_xE_y, where RE may be one or more Rare Earth elements (for example, Eu or Gd), A may be one or more elements selected from the group Mg, Ca, Sr, or Ba, M may be one or more elements selected from the group Al, Ga, B, In, Sc, Lu or Y, E may be one or more elements selected from the group S, Se, O, or Te, w is greater than or equal to zero, or greater than or equal to 0.01, or greater than or equal to 0.05, and less than or equal to about 0.8, 2≤x≤4, and 4≤y≤7.
FILED	Friday, May 25, 2018
APPL NO	15/990378
ART UNIT	2895 — Semiconductors/Memory
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7734 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/56 (20130101) H01L 33/502 (20130101) Original (OR) Class H01L 33/507 (20130101) H01L 2933/005 (20130101) H01L 2933/0041 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10235589 — Small maritime target detector

US 10235589	Hawes et al.
FUNDED BY
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Chad M. Hawes (Finksburg, Maryland); David N. Barsic (Laurel, Maryland); Howard C. Schoeberlein (Ellicott City, Maryland); Eric D. Jansing (Cathedral City, California); Michael E. Nord (Columbia, Maryland); Eric C. Larsen (Hanover, Maryland)
ABSTRACT	A detection system may include processing circuitry configured to receive synthetic aperture radar image data that has been or will be divided into a plurality of image tiles and perform initial screening to reject image tiles not having a threshold level of energy. The processing circuitry may be further configured to perform advanced screening to eliminate image tiles based on background noise to generate screened image tiles and generate a feature vector for an energy return of the screened image tiles. The processing circuitry may also be configured to determine a classification of a target associated with the feature vector.
FILED	Wednesday, September 07, 2016
APPL NO	15/258269
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/3233 (20130101) Original (OR) Class G06K 2209/21 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, March 19, 2019.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20190319.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

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