FedInvent™ Patents

Patent Details for Tuesday, June 04, 2019

This page was updated on Monday, March 27, 2023 at 05:49 AM GMT

Department of Health and Human Services (HHS)

10306887 — Composition and methods for modulation of the octopamine receptor and its homologs

US 10306887	Han
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Minority Health and Health Disparities (NIMHD) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Kyung-an Han (El Paso, Texas)
ASSIGNEE(S)	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMS (Austin, Texas)
INVENTOR(S)	Kyung-an Han (El Paso, Texas)
ABSTRACT	Embodiments of the invention are directed of compositions for activation or inhibition of the Octβ2 receptor and uses thereof. The inventors have discovered that the beta adrenergic-like octopamine receptor Octβ2 serves as a key signaling molecule for ovulation and recruits protein kinase A and Ca2+/calmodulin-sensitive kinase II as downstream effectors for this activity. Octβ2R homozygous mutant females are sterile, and display normal courtship, copulation, sperm storage and post-mating rejection behavior but were unable to lay eggs.
FILED	Tuesday, August 04, 2015
APPL NO	15/501504
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 33/04 (20130101) A01N 33/06 (20130101) A01N 43/50 (20130101) A01N 45/02 (20130101) A01N 47/22 (20130101) Original (OR) Class Peptides C07K 14/43563 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5041 (20130101) G01N 2333/43552 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307088 — Systems and methods for measuring oxygenation

US 10307088	Esenaliev et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	The Board of Regents of the University of Texas (Austin, Texas)
INVENTOR(S)	Rinat Esenaliev (League City, Texas); Donald S. Prough (Galveston, Texas); Yuriy Petrov (Galveston, Texas); Irene Petrov (Galveston, Texas); George Saade (Houston, Texas); Gayle L. Olson (Galveston, Texas)
ABSTRACT	Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.
FILED	Wednesday, July 08, 2015
APPL NO	14/794022
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0095 (20130101) A61B 5/742 (20130101) A61B 5/1459 (20130101) A61B 5/1464 (20130101) A61B 5/6814 (20130101) A61B 5/6875 (20130101) A61B 5/14542 (20130101) Original (OR) Class A61B 5/14553 (20130101) A61B 2562/0271 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307106 — Systems and methods for estimating and removing magnetic resonance imaging gradient field-induced voltages from electrophysiology signals

US 10307106	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts); UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia)
ASSIGNEE(S)	BRIGHAM AND WOMEN'S HOSPTIAL, INC. (Boston, Massachusetts); UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia)
INVENTOR(S)	Wei Wang (Auburndale, Massachusetts); HuaLei Zhang (Brookline, Massachusetts); Ehud J. Schmidt (Newton, Massachusetts); Tsz Ho Tse (Lawrenceville, Georgia)
ABSTRACT	Systems and methods for estimating time-dependent voltages that are induced in electrophysiological monitoring systems by magnetic field gradients generated during a magnetic resonance imaging (“MRI”) scan are provided. The gradient-induced voltages are subsequently removed from signals acquired with the electrophysiological monitoring system during an MRI scan. As an example, the electrophysiological monitoring system can include an electrocardiography (“ECG”) system, an electroencephalography (“EEG”) system, an electromyography (“EMG”) system, a voltage device tracking (“VDT”) system, and so on. The gradient-induced voltages are estimated using a two-step procedure in which a learning algorithm is used to determine fitting parameters to be used in a model of the gradient-induced voltages. The fitting parameters are then used together with the model to extract the gradient-induced voltages from signals acquired during an MRI scan. The gradient-induced voltages can then be removed from the acquired signals.
FILED	Friday, July 10, 2015
APPL NO	15/325323
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/0402 (20130101) A61B 5/0476 (20130101) A61B 5/0488 (20130101) A61B 5/725 (20130101) A61B 5/7217 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5673 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307139 — System, method and computer-accessible medium for diffusion imaging acquisition and analysis

US 10307139	Boada et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	New York University (New York, New York)
ASSIGNEE(S)	NEW YORK UNIVERSITY (New York, New York)
INVENTOR(S)	Fernando Boada (Purchase, New York); Steven Baete (Summit, New Jersey); Jingyun Chen (East Rutherford, New Jersey); Ricardo Otazo (New York, New York)
ABSTRACT	Exemplary system, method and computer-accessible medium for determining a difference(s) between two sets of subjects, can be provided. Using such exemplary system, method and computer-accessible medium, it is possible to receive first imaging information related to a first set of subjects of the two sets of the subjects, receive second imaging information related to a second set of subjects of the two sets of subjects, generate third information by performing a decomposition procedure(s) on the first imaging information and the second information, and determine the difference(s) based on the third information.
FILED	Monday, January 30, 2017
APPL NO	15/419508
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/0066 (20130101) A61B 5/4064 (20130101) A61B 6/032 (20130101) A61B 6/501 (20130101) A61B 6/5217 (20130101) A61B 6/5229 (20130101) A61B 8/0808 (20130101) A61B 8/5223 (20130101) A61B 8/5238 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) G01R 33/56341 (20130101) Image Data Processing or Generation, in General G06T 7/0014 (20130101) G06T 2207/10092 (20130101) G06T 2207/30016 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307201 — Methods and devices for use of degassed fluids with fluid enhanced ablation devices

US 10307201	Curley
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Thermedical, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	Thermedical, Inc. (Waltham, Massachusetts)
INVENTOR(S)	Michael G. Curley (Weston, Massachusetts)
ABSTRACT	Devices, systems, and methods for degassing fluid prior to applying fluid to a treatment site during ablation therapy are provided. In one embodiment, an ablation system can include an elongate body, an ablation element, a heating assembly, and a fluid source. Fluid in the fluid source can be at least partially degassed prior to being provided as part of the system, or, in some embodiments, a degassing apparatus can be provided that can be configured to degas fluid within the system prior to applying the fluid to the treatment site. The degassing apparatus can include one or more gas-permeable and fluid-impermeable tubes disposed therein, which can allow gas to be removed from fluid passing through the apparatus. Other exemplary devices, systems, and methods are also provided.
FILED	Friday, August 14, 2015
APPL NO	14/826563
ART UNIT	3739 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/04 (20130101) Original (OR) Class A61B 18/16 (20130101) A61B 18/082 (20130101) A61B 18/1477 (20130101) A61B 2017/00526 (20130101) A61B 2018/00029 (20130101) A61B 2018/00041 (20130101) A61B 2018/046 (20130101) A61B 2018/162 (20130101) A61B 2018/00577 (20130101) A61B 2018/00642 (20130101) A61B 2018/00773 (20130101) A61B 2018/00791 (20130101) A61B 2018/00797 (20130101) A61B 2018/00809 (20130101) A61B 2018/00821 (20130101) A61B 2018/1425 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 17/03 (20130101) F04B 19/22 (20130101) F04B 43/04 (20130101) F04B 49/06 (20130101) Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps F04C 2270/041 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49016 (20150115) Y10T 29/49085 (20150115)
VIEW PATENT	@ USPTO: Full Text PDF

10307207 — Nanoelectroablation control and vaccination

US 10307207	Nuccitelli et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Pulse Biosciences, Inc. (Hayward, California)
ASSIGNEE(S)	PULSE BIOSCIENCES, INC. (Hayward, California)
INVENTOR(S)	Richard Lee Nuccitelli (Millbrae, California); Jon Casey Berridge (Oakland, California); Zachary Mallon (San Francisco, California); Mark Kreis (San Francisco, California); Brian Athos (San Francisco, California); Pamela Nuccitelli (Millbrae, California)
ABSTRACT	Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.
FILED	Thursday, July 19, 2018
APPL NO	16/040434
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/04 (20130101) A61B 6/03 (20130101) A61B 6/12 (20130101) A61B 18/1477 (20130101) A61B 18/1492 (20130101) Original (OR) Class A61B 34/20 (20160201) A61B 90/37 (20160201) A61B 2018/00273 (20130101) A61B 2018/00529 (20130101) A61B 2018/00577 (20130101) A61B 2018/00613 (20130101) A61B 2018/00642 (20130101) A61B 2018/00892 (20130101) A61B 2018/00904 (20130101) A61B 2018/00982 (20130101) A61B 2034/101 (20160201) A61B 2034/107 (20160201) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2037/0007 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/40 (20130101) A61N 1/326 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307214 — Modular sterilizable robotic system for endonasal surgery

US 10307214	Lathrop et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee)
INVENTOR(S)	Ray Lathrop (Indianapolis, Indiana); Trevor L. Bruns (Nashville, Tennessee); Arthur W. Mahoney (Nashville, Tennessee); Hunter B. Gilbert (Nashville, Tennessee); Philip J. Swaney (Nashville, Tennessee); Richard J. Hendrick (Nashville, Tennessee); Kyle Weaver (Nashville, Tennessee); Paul T. Russell (Nashville, Tennessee); Stanley Duke Herrell (Nashville, Tennessee); Robert J. Webster (Nashville, Tennessee)
ABSTRACT	A surgical robot system includes a support structure for positioning relative to a patient. The support structure includes a plurality of mounting structures. One or more robotic tool cassettes that are configured to interchangeably connect with any of the mounting structures. Each tool cassette includes a concentric tube manipulator and a transmission for operating the concentric tube manipulator. The support structure also includes a tube collector including a tube assembly associated with each of the mounting structures. The tube assemblies are configured to receive the concentric tube manipulators and guide the manipulators to extend along predetermined trajectories relative to each other.
FILED	Wednesday, November 23, 2016
APPL NO	15/360087
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Diagnosis; Surgery; Identification A61B 34/20 (20160201) A61B 34/30 (20160201) Original (OR) Class A61B 34/35 (20160201) A61B 34/37 (20160201) A61B 90/37 (20160201) A61B 2034/301 (20160201)
VIEW PATENT	@ USPTO: Full Text PDF

10307340 — Devices for clearing blockages in artificial and natural lumens

US 10307340	Bagwell et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Science Foundation (NSF)
APPLICANT(S)	Actuated Medical, Inc. (Bellefonte, Pennsylvania)
ASSIGNEE(S)	Actuated Medical, Inc. (Bellefonte, Pennsylvania)
INVENTOR(S)	Roger B Bagwell (Bellefonte, Pennsylvania); Ryan S Clement (State College, Pennsylvania); Katherine M Erdley (Boalsburg, Pennsylvania); Maureen L Mulvihill (Bellefonte, Pennsylvania); Casey A Scruggs (Middleburg, Pennsylvania); Douglas R Dillon (Port Matilda, Pennsylvania); Timothy J Higgins (Mingoville, Pennsylvania)
ABSTRACT	An occlusion clearing device for a patient has a housing with a motor(s) that generates repetitive motion, which is reciprocating, rotational or both. A clearing stem including a sheath that has a lumen, wherein aspiration is conducted through the sheath lumen. A wire is located in the sheath lumen and receives repetitive motion from the controller. The sheath terminates in a sheath end having at least one sheath opening. The wire terminates in a wire tip, which may be flat, helical, or tubular. The wire tip is positioned within the sheath end, in proximity to the sheath opening(s), and movement of the wire tip and/or sheath end relative to each other creates shearing forces that break up an adjacent occlusion.
FILED	Friday, July 29, 2016
APPL NO	15/223787
ART UNIT	3781 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/22 (20130101) A61B 17/3207 (20130101) A61B 17/22012 (20130101) A61B 17/320758 (20130101) A61B 17/320783 (20130101) A61B 90/70 (20160201) A61B 2017/00477 (20130101) A61B 2017/00685 (20130101) A61B 2017/00876 (20130101) A61B 2017/22014 (20130101) A61B 2017/22079 (20130101) A61B 2017/320012 (20130101) A61B 2017/320028 (20130101) A61B 2017/320733 (20130101) A61B 2017/320775 (20130101) A61B 2090/034 (20160201) A61B 2090/701 (20160201) A61B 2217/005 (20130101) A61B 2217/007 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 15/0003 (20130101) A61J 15/0026 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/0084 (20130101) A61M 3/0279 (20130101) A61M 25/00 (20130101) A61M 25/0082 (20130101) A61M 39/00 (20130101) A61M 2025/0019 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307398 — Resuscitation composition and methods of making and using

US 10307398	Beilman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Gregory Beilman (Richfield, Minnesota); Andrea Wolf (Minneapolis, Minnesota); Raj Suryanarayanan (Roseville, Minnesota); Seema Thakral (Fridley, Minnesota)
ABSTRACT	A resuscitation composition is described herein, as are methods of making and using such a composition.
FILED	Wednesday, September 20, 2017
APPL NO	15/710389
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0019 (20130101) A61K 9/19 (20130101) A61K 31/19 (20130101) A61K 31/4045 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/32 (20130101) A61K 47/34 (20130101) A61K 47/40 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

10307401 — Compositions and methods for treatment of prostate cancer

US 10307401	Dervan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Peter B. Dervan (San Marino, California); Nickolas G. Nickols (Van Nuys, California); Fei Yang (Pasadena, California); Alexis A. Kurmis (Rochester, New York)
ABSTRACT	The present invention relates to compositions and methods for the treatment of prostate cancer. The present invention relates to polyamides and prostate agents, for example, to inhibit an androgen receptor signaling axis, and the use of these compositions in the treatment of prostate cancer.
FILED	Monday, August 28, 2017
APPL NO	15/688785
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/4166 (20130101) A61K 31/4166 (20130101) A61K 31/4178 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307406 — Methods and compositions for re-activating Epstein-Barr virus and screening compounds therefor

US 10307406	Lieberman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania); Drexel University (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania); Drexel University (Philadelphia, Pennsylvania)
INVENTOR(S)	Paul M. Lieberman (Wynnewood, Pennsylvania); Nadezhda Tikhmyanova-Eckert (Cheltenham, Pennsylvania); Joseph M. Salvino (Chester Springs, Pennsylvania)
ABSTRACT	In an effort to discover therapies for treating diseases caused by EBV, a novel screening assay for identifying compounds that reactivate EBV latent infection and a family of small molecules based on a tetrahydrocarboline backbone were discovered. Specifically, the compounds have the structure of the formula (I), wherein R¹-R¹¹are defined herein and activate/reactivate EBV in a variety of cell types in a patient and are, therefore, useful in preventing or treating EBV-positive cancer, optionally with an anti-viral agent. In screening these compounds, novel compositions, EBV-positive cell lines, and methods are provided. (Formula I)
FILED	Friday, August 29, 2014
APPL NO	14/912949
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/69 (20130101) A61K 31/437 (20130101) Original (OR) Class A61K 31/437 (20130101) A61K 31/522 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307415 — Epimorphic regeneration and related hydrogel delivery systems

US 10307415	Messersmith et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Northwestern University (Evanston, Illinois); The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois); The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania)
INVENTOR(S)	Phillip B. Messersmith (Clarendon Hills, Illinois); Iossif A. Strehin (Lincolnshire, Illinois); Ellen Heber-Katz (Philadelphia, Pennsylvania)
ABSTRACT	Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.
FILED	Friday, June 09, 2017
APPL NO	15/618715
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4745 (20130101) Original (OR) Class A61K 47/60 (20170801) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/332 (20130101) C08G 65/333 (20130101) C08G 65/3342 (20130101) C08G 65/3344 (20130101) C08G 65/3348 (20130101) C08G 65/33331 (20130101) C08G 65/33337 (20130101) C08G 65/33396 (20130101) C08G 2210/00 (20130101) C08G 2650/32 (20130101) C08G 2650/58 (20130101) Compositions of Macromolecular Compounds C08L 2203/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) Enzymes C12Y 114/11002 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307423 — FBXO3 inhibitors

US 10307423	Chen et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Beibei Chen (Wexford, Pennsylvania); Rama K. Mallampalli (Sewickley, Pennsylvania)
ABSTRACT	A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R¹-R¹⁰are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R³or R⁸is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.
FILED	Monday, April 25, 2016
APPL NO	15/138120
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/341 (20130101) A61K 31/381 (20130101) A61K 31/402 (20130101) A61K 31/427 (20130101) A61K 31/435 (20130101) A61K 31/444 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4178 (20130101) A61K 31/4418 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 11/06 (20180101) A61P 19/00 (20180101) A61P 25/00 (20180101) A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 211/01 (20130101) C07C 211/53 (20130101) C07C 229/38 (20130101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 211/14 (20130101) C07D 213/06 (20130101) C07D 213/36 (20130101) C07D 213/38 (20130101) C07D 231/12 (20130101) C07D 233/61 (20130101) C07D 233/64 (20130101) C07D 239/26 (20130101) C07D 265/30 (20130101) C07D 277/28 (20130101) C07D 295/135 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) Technologies for Adaptation to Climate Change Y02A 50/411 (20180101) Y02A 50/473 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

10307425 — Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases

US 10307425	Hol et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington)
ASSIGNEE(S)	University of Washington (Seattle, Washington)
INVENTOR(S)	Wilhelmus G. J. Hol (Seattle, Washington); Eric T. Larson (Seattle, Washington); Dustin James Maly (Seattle, Washington); Wesley C. Van Voorhis (Seattle, Washington); Ethan Merritt (Seattle, Washington); Kayode K. Ojo (Seattle, Washington)
ABSTRACT	The present disclosure is directed to compositions and methods for inhibiting either Toxoplasma gondii (T. gondii) calcium dependent protein kinases (TgCDPKs) or Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-α]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R¹, and R³are defined herein.
FILED	Tuesday, January 26, 2016
APPL NO	15/544606
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/4985 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Technologies for Adaptation to Climate Change Y02A 50/411 (20180101) Y02A 50/488 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

10307437 — Methods for treatment of vascular endothelial dysfunction using nicotinamide mononucleotide

US 10307437	Seals et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	The Regents of the University of Colorado, a Body Corporate (Denver, Colorado)
ASSIGNEE(S)	The Regents of the University of Colorado, a Body Corporate (Denver, Colorado)
INVENTOR(S)	Douglas R. Seals (Boulder, Colorado); Lindsey Gano (Denver, Colorado); Natalie Poliektor (Denver, Colorado)
ABSTRACT	This invention is about the compositions and methods for assessing and treating vascular endothelial dysfunction. Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject. In one embodiment the dose is administered to subjects in response to the indicator. In another embodiment the dose is administered chronically to subjects.
FILED	Tuesday, March 24, 2015
APPL NO	15/126548
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/706 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10307469 — Synthetic methylmalonyl-CoA mutase transgene for the treatment of MUT class methylmalonic acidemia (MMA)

US 10307469	Venditti et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
INVENTOR(S)	Charles P. Venditti (Potomac, Maryland); Randy J. Chandler (Washington, District of Columbia)
ABSTRACT	Synthetic polynucleotides encoding human methylmalonyl-CoA mutase (synMUT) and exhibiting augmented expression in cell culture and/or in a subject are described herein. An adeno-associated viral (AAV) gene therapy vector encoding synMUT under the control of a liver-specific promoter (AAV2/8-HCR-hAAT-synMUT-RBG) successfully rescued the neonatal lethal phenotype displayed by methylmalonyl-CoA mutase-deficient mice, lowered circulating methylmalonic acid levels in the treated animals, and resulted in prolonged hepatic expression of the product of synMUT transgene in vivo, human methylmalonyl-CoA mutase (MUT).
FILED	Tuesday, June 27, 2017
APPL NO	15/633964
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/52 (20130101) Original (OR) Class A61K 48/0066 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) Enzymes C12Y 504/99002 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307473 — Capsular gram-positive bacteria bioconjugate vaccines

US 10307473	Wacker et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	GLAXOSMITHKLINE BIOLOGICALS S.A. (Rixensart, Belgium)
ASSIGNEE(S)	GlaxoSmithKline Biologicals SA (Rixensart, Belgium)
INVENTOR(S)	Michael Wacker (Unterengstringen, Switzerland); Michael Kowarik (Zurich, Switzerland); Michael Wetter (Zurich, Switzerland)
ABSTRACT	The present invention encompasses a novel S. aureus bioconjugate vaccine. More generally, the invention is directed to Gram-positive and other bioconjugate vaccines containing a protein carrier, at least one polysaccharide such as a capsular Gram-positive polysaccharide, and, optionally, an adjuvant or pharmaceutically acceptable carrier. The instant invention also includes methods of producing Gram-positive and other bioconjugate vaccines. An N-glycosylated protein is also provided that contains one or more polysaccharides such as Gram-positive polysaccharides. The invention is additionally directed to engineered prokaryotic organisms comprising nucleotide sequences encoding a glycosyltransferase of a first prokaryotic organism and a glycosyltransferase of a second prokaryotic organism. The invention further includes plasmids and prokaryotic cells transformed with plasmids encoding polysaccharides and enzymes which produce an N-glycosylated protein and/or bioconjugate vaccine. Further, the invention is directed to methods of inducing an immune response in a mammal comprising administering said bioconjugate vaccines.
FILED	Wednesday, January 25, 2017
APPL NO	15/414900
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/085 (20130101) Original (OR) Class A61K 2039/64 (20130101) A61K 2039/70 (20130101) A61K 2039/505 (20130101) A61K 2039/575 (20130101) A61K 2039/6037 (20130101) A61K 2039/6087 (20130101) Peptides C07K 14/21 (20130101) C07K 16/1271 (20130101) C07K 2317/734 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/21 (20130101) C07K 2319/034 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1029 (20130101) C12N 9/1048 (20130101) C12N 15/70 (20130101) C12N 15/74 (20130101) Technologies for Adaptation to Climate Change Y02A 50/47 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

10307476 — Genetically stable live attenuated respiratory syncytial virus vaccine and its production

US 10307476	Collins et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Peter L. Collins (Silver Spring, Maryland); Cindy L. Luongo (Bethesda, Maryland); Ursula J. Buchholz (Silver Spring, Maryland); Brian R. Murphy (Bethesda, Maryland)
ABSTRACT	Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.
FILED	Friday, March 10, 2017
APPL NO	15/455438
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/155 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/18521 (20130101) C12N 2760/18522 (20130101) C12N 2760/18534 (20130101) C12N 2760/18562 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307478 — Biochemically stabilized HIV-1 Env trimer vaccine

US 10307478	Harrison et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Beth Israel Deaconess Medical Center (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Stephen C. Harrison (Brighton, Massachusetts); Bing Chen (Chestnut Hill, Massachusetts); Dan H. Barouch (Boston, Massachusetts); Joseph P. Nkolola (Watertown, Massachusetts); Michael Scott Seaman (West Roxbury, Massachusetts)
ABSTRACT	Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
FILED	Tuesday, March 13, 2018
APPL NO	15/919834
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/54 (20130101) A61K 2039/545 (20130101) A61K 2039/575 (20130101) A61K 2039/55566 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16051 (20130101) C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) C12N 2740/16171 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307487 — Microvessel endothelial cell surface markers and uses thereof

US 10307487	von Andrian et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL INC. (Boston, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); The Brigham and Women's Hospital (Boston, Massachusetts)
INVENTOR(S)	Ulrich H. von Andrian (Brookline, Massachusetts); Aude Thiriot (Brookline, Massachusetts); Omid Farokhzad (Waban, Massachusetts); Jinjun Shi (Boston, Massachusetts)
ABSTRACT	Disclosed herein are microvessel endothelial cell surface markers and methods, compositions, agents, and kits relating to those surface markers.
FILED	Wednesday, July 09, 2014
APPL NO	14/903964
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 47/6849 (20170801) A61K 47/48561 (20130101) Original (OR) Class A61K 49/00 (20130101) A61K 49/0058 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5064 (20130101) G01N 2333/705 (20130101) Technologies for Adaptation to Climate Change Y02A 50/385 (20180101) Y02A 50/406 (20180101) Y02A 50/409 (20180101) Y02A 50/411 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

10307490 — Lipid nanoparticle compositions for antisense oligonucleotides delivery

US 10307490	Lee et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Ohio State University (Columbus, Ohio)
ASSIGNEE(S)	The Ohio State University (Columbus, Ohio)
INVENTOR(S)	Robert J. Lee (Columbus, Ohio); Young Bok Lee (Clarksburg, Maryland); Deog Joong Kim (Rockville, Maryland); Chang Ho Ahn (Potomac, Maryland)
ABSTRACT	Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed.
FILED	Thursday, May 23, 2013
APPL NO	13/900969
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 9/1271 (20130101) A61K 9/1272 (20130101) A61K 31/713 (20130101) A61K 31/7088 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/482 (20130101) A61K 45/06 (20130101) A61K 47/59 (20170801) A61K 47/543 (20170801) A61K 47/643 (20170801) Original (OR) Class A61K 47/6911 (20170801) A61K 48/00 (20130101) Peptides C07K 16/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1135 (20130101) C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) Enzymes C12Y 304/21064 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307491 — Liposomal particles comprising biological molecules and uses thereof

US 10307491	Moon et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	James Jaehyun Moon (Ann Arbor, Michigan); Yuchen Fan (Ann Arbor, Michigan); Preety Sahdev (Aliso Viejo, California); Joseph Bazzill (Ann Arbor, Michigan)
ABSTRACT	Provided herein are liposomal particles. In particular, provided herein are liposomal particles comprising molecules (e.g., antigens or drugs) and uses thereof (e.g., as a vaccine (e.g., intranasal vaccine) or drug delivery system). For example, in some embodiments, the present disclosure provides a composition comprising: a molecule encapsulated in a liposome comprising one or more cationic lipids and hyaluronic acid (HA). In some embodiments, the one or more lipids are DOTAP and/or DOPE. In some embodiments, the HA is thiolated. In some embodiments, the thiolated HA is conjugated to thiolated PEG.
FILED	Thursday, January 28, 2016
APPL NO	15/547389
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/1271 (20130101) A61K 31/722 (20130101) A61K 31/728 (20130101) A61K 47/10 (20130101) A61K 47/60 (20170801) A61K 47/6911 (20170801) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10307492 — Modified MGLUR6 promoter and methods of use

US 10307492	Pan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Wayne State University (Detroit, Michigan)
ASSIGNEE(S)	Wayne State University (Detrot, Michigan)
INVENTOR(S)	Zhuo-Hua Pan (Troy, Michigan); Qi Lu (Detroit, Michigan); Tushar H. Ganjawala (Canton, Michigan); JrGang Cheng (Chapel Hill, North Carolina)
ABSTRACT	The invention provides nucleic acids and nucleic acid expression vectors containing optimized mGluR6 promoters for expression of transgenes in the retina. The compositions and methods of the invention are useful for expression of gene products to preserve, improve, or restore phototransduction or vision.
FILED	Wednesday, March 11, 2015
APPL NO	15/125066
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/1787 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0075 (20130101) Peptides C07K 14/70571 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/85 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2830/008 (20130101) C12N 2830/42 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307493 — Imageable embolic microsphere

US 10307493	Dreher et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Biocompatibles UK Limited (Surrey, United Kingdom); Matthew R. Dreher (West Conshohocken, Pennsylvania); Bradford J. Wood (Bethesda, Maryland); Ayele H. Negussie (Bethesda, Maryland); Andrew Leonard Lewis (Surrey, United Kingdom); Yiqing Tang (Surrey, United Kingdom)
ASSIGNEE(S)	Biocompatible UK Limited (Farnham, Surrey, United Kingdom); National Institutes of Health (Bethesda, Maryland)
INVENTOR(S)	Matthew R. Dreher (West Conshohocken, Pennsylvania); Bradford J. Wood (Bethesda, Maryland); Ayele H. Negussie (Bethesda, Maryland); Andrew Leonard Lewis (Surrey, United Kingdom); Yiqing Tang (Surrey, United Kingdom)
ABSTRACT	This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
FILED	Friday, March 14, 2014
APPL NO	14/777168
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0438 (20130101) A61K 49/0442 (20130101) Original (OR) Class A61K 49/0476 (20130101) A61K 49/0485 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 116/06 (20130101) Compositions of Macromolecular Compounds C08L 29/04 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307527 — Protein-based nanobubble x-ray imaging method and agent

US 10307527	Rose-Petruck et al.
FUNDED BY	Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Brown University (Providence, Rhode Island); MONTANA STATE UNIVERSITY (Bozeman, Montana)
ASSIGNEE(S)	Brown University (Providence, Rhode Island); Montana State University (Bozeman, Montana)
INVENTOR(S)	Christoph Rose-Petruck (Barrington, Rhode Island); Trevor Douglas (Bloomington, Indiana); Danielle Rand (Walpole, Massachusetts); Masaki Uchida (Bloomington, Indiana)
ABSTRACT	Systems, compositions, methods and kits employ protein shells, such as ferritin or viral capsid shells, herein called nanobubbles, to enhance X-ray images of cells or body tissue under certain x-ray imaging methods. The nanobubbles have sub-micron size such as about 10 nm, about 40, 60, or 100 nm and may be functionalized for effective delivery to or uptake by a target tissue, in vivo or a cell culture. The nanobubbles are hollow, having a central core which may be empty or contain a fluid, such that the shells effectively form long-lived bubbles in the imaged environment, and are of low electron density and have different scattering properties than the surrounding tissue. X-ray imaging by spatial frequency heterodyne imaging enhances visualization or detection of tissue regions bearing the shells. The protein shells may be further treated to assure biocompatibility and/or to resist undesired interactions with non-targeted tissue, such as scavenging by the liver, or attack by the immune system. For example the nanobubbles may be filled with a hydrophobic gas such as perfluoropropane (octafluoropropane) to maintain their shape and resist hydrophilic interactions and delay the degradation of the protein shells. The nanobubbles may also be coated or treated by a surface-functionalization processes to effectively target specific tissues or tumor types, allow parenteral delivery, and/or deliver drugs or other agents to the imaged sites—so that when visualized by X-ray scatter imaging the presence of the nanobubbles indicates the existence and extent of the tumor or diseased tissue.
FILED	Tuesday, April 21, 2015
APPL NO	14/692075
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/06 (20130101) A61B 6/481 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0461 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/007 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10307585 — Systems and methods to place one or more leads in tissue to electrically stimulate nerves of passage to treat pain

US 10307585	Boggs et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	SPR THERAPEUTICS, INC. (Cleveland, Ohio)
ASSIGNEE(S)	SPR THERAPEUTICS, INC. (Cleveland, Ohio)
INVENTOR(S)	Joseph W. Boggs (Chapel Hill, North Carolina); Rosemary H. Zang (Avon Lake, Ohio)
ABSTRACT	Systems and methods are provided for applying electrical stimulation to a body by an electrode spaced from a target nerve of passage. It has been discovered that pain felt, or perceived to be felt, in a given region of the body can be treated by stimulating muscle close to a “nerve of passage” in a region that is superior (i.e., cranial or upstream toward the spinal column) to the region where pain is felt, such as in a case of post-amputation residual limb pain, or purportedly felt in the case of post-amputation phantom limb pain.
FILED	Monday, February 19, 2018
APPL NO	15/898889
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/061 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/0502 (20130101) A61N 1/0551 (20130101) Original (OR) Class A61N 1/0558 (20130101) A61N 1/36017 (20130101) A61N 1/36021 (20130101) A61N 1/36071 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307609 — Compositions and methods for controlling pain

US 10307609	Iyer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Circuit Therapeutics, Inc. (Menlo Park, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Circuit Therapeutics, Inc. (Menlo Park, California)
INVENTOR(S)	Shrivats Mohan Iyer (Stanford, California); Scott L. Delp (Stanford, California); Kathryn L. Montgomery (Stanford, California); Karl A. Deisseroth (Stanford, California); Christopher Towne (San Francisco, California)
ABSTRACT	The present disclosure provides compositions and methods for controlling pain. The present disclosure provides methods for identifying agents that control pain.
FILED	Wednesday, August 13, 2014
APPL NO	14/911405
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 67/0278 (20130101) A01K 2207/15 (20130101) A01K 2217/07 (20130101) A01K 2217/072 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) A01K 2267/0393 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) A61K 41/00 (20130101) A61K 48/0058 (20130101) A61K 48/0075 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 5/0622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8509 (20130101) C12N 2015/8527 (20130101) C12N 2750/14141 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308591 — Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure

US 10308591	Wainer et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
INVENTOR(S)	Irving William Wainer (Washington, District of Columbia); Weizhong Zhu (Philadelphia, Pennsylvania); Khalid Chakir (Baltimore, Maryland); Rui-Ping Xiao (Baltimore, Maryland); Darrell R. Abernethy (Annapolis, Maryland); Farideh M. Beigi Abhari (Durham, North Carolina)
ABSTRACT	This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogs which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogs are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogs, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
FILED	Thursday, January 18, 2018
APPL NO	15/874747
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 215/60 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10308596 — HDAC8 inhibitors for treating cancer

US 10308596	Kuo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	City of Hope (Duarte, California); Taipei Medical University (Taipei, Taiwan); Academia Sinica (Taipei, Taiwan)
ASSIGNEE(S)	CITY OF HOPE (Duarte, California); TAIPEI MEDICAL UNIVERSITY (Taipei, Taiwan); ACADEMIA SINICA (Taipei, Taiwan)
INVENTOR(S)	Ya-Huei Kuo (Duarte, California); Wei-Jan Huang (Taipei, Taiwan); Chung-I Chang (Taipei, Taiwan)
ABSTRACT	Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.
FILED	Thursday, February 11, 2016
APPL NO	15/042012
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 259/06 (20130101) Original (OR) Class Heterocyclic Compounds C07D 209/08 (20130101) C07D 209/18 (20130101) C07D 213/56 (20130101) C07D 213/74 (20130101) C07D 215/14 (20130101) C07D 217/16 (20130101) C07D 217/20 (20130101) C07D 307/91 (20130101) C07D 317/60 (20130101) C07D 333/24 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308624 — Catalytic enantioselective synthesis of 2-aryl chromenes and related phosphoramidite ligands and catalyst compounds

US 10308624	Scheidt et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	Karl A. Scheidt (Evanston, Illinois); Bi-Shun Zeng (Chicago, Illinois)
ABSTRACT	Methods to access 2-aryl chromene compounds via an asymmetric catalytic process.
FILED	Monday, December 11, 2017
APPL NO	15/837740
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	General Methods of Organic Chemistry; Apparatus Therefor C07B 53/00 (20130101) Heterocyclic Compounds C07D 311/32 (20130101) C07D 311/60 (20130101) Original (OR) Class C07D 311/62 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/59 (20130101) C07F 9/65515 (20130101) C07F 9/657154 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308638 — Selective alpha-7 nicotinic receptor agonists and methods for making and using them

US 10308638	Taylor et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The Regents of the University of California (Oakland, California); The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Palmer Taylor (La Jolla, California); Gisela-Andrea Camacho-Hernandez (La Jolla, California); Karl Barry Sharpless (La Jolla, California); M. G. Finn (La Jolla, California); Valery Fokin (Los Angeles, California)
ABSTRACT	In alternative embodiments, provided are selective agonists having a high affinity for the alpha7 nicotinic acetylcholine receptor (α7 nAChR), assays for selectivity of nicotinic receptor subtype and ligand-gated ion channel subtype based on receptor occupation and response, behavioral assessments for reversing cognitive impairment after scopolamine treatment, enhancing memory retention over time, pharmaceutical compositions and formulations and devices comprising them, and methods for making and using them, including characterizing and efficiently assaying them for receptor subtype selectivity. In alternative embodiments, provided are substituted anti 1,2,3-triazoles compounds with high affinity, and selective binding, for the alpha7 nicotine acetylcholine receptor (α7 nAChR), as exemplified by 5-(1-(2-(Piperidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)-1H-indole (“IND1”), 5-((quinuclid-3-yl)-1H-1,2,3-triazol-4-yl)-1H-indole (“IND8”) and 3-(4-hydroxyphenyl-1,2,3-triazol-1-yl) quinuclidine (“QND8”). In alternative embodiments, provided are products of manufacture such as pumps, devices, syringes and the like comprising a compound, pharmaceutical composition or formulation as provided herein.
FILED	Thursday, March 24, 2016
APPL NO	15/558986
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/46 (20130101) A61K 31/55 (20130101) A61K 31/439 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/4192 (20130101) A61K 31/5377 (20130101) Heterocyclic Compounds C07D 249/06 (20130101) C07D 401/14 (20130101) C07D 403/04 (20130101) Original (OR) Class C07D 405/04 (20130101) C07D 451/04 (20130101) C07D 451/14 (20130101) C07D 453/02 (20130101) C07D 473/34 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308649 — Compounds and methods to suppress autoimmune response

US 10308649	Kerkvliet et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	Oregon State University (Corvallis, Oregon)
ASSIGNEE(S)	Oregon State University (Corvallis, Oregon)
INVENTOR(S)	Nancy I. Kerkvliet (Corvallis, Oregon); Siva Kumar Kolluri (Corvallis, Oregon)
ABSTRACT	A composition and method for treating autoimmune disease includes administering an effective amount of an aryl hydrocarbon receptor (AhR) ligand. The AhR ligand includes 11-Cl-BBQ, 10-Cl-BBQ, an analog of 11-Cl-BBQ, or combination thereof. The AhR ligand is administered topically, orally, transdermally, intravenously, subcutaneously, or with a nanoparticle. The AhR ligand induces regulatory T cells (AhR-Tregs). AhR-Treg cells block the differentiation of cytotoxic T-lymphocytes (CTL). The AhR ligand activates AhR in CD4+ T cells to induce CD4+ AhR-Tregs that suppress the development of effector CTL, thereby suppressing the development of CTL that attack host cells in graft versus host disease (GVHD) or β-cells in the pancreas in diabetes mellitus type 1 (T1DM). The AhR ligand can also suppress development of CTL independently of Foxp3+ regulatory T cell induction. The AhR ligand can therefore be used to treat autoimmune diseases characterized by an absence of functional Foxp3+ regulatory T cell.
FILED	Wednesday, October 28, 2015
APPL NO	15/522241
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/407 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10308653 — Diazepane derivatives and uses thereof

US 10308653	Bradner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S)	James E. Bradner (Weston, Massachusetts); Dennis Buckley (Boston, Massachusetts)
ABSTRACT	The present disclosure provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) have been found to bind bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits of the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, neurological diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.
FILED	Tuesday, February 07, 2017
APPL NO	15/426708
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10308656 — Small molecule inhibitors of Ku70/80 and uses thereof

US 10308656	Weterings et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona)
INVENTOR(S)	Eric Weterings (Tucson, Arizona); Daruka Mahadevan (Tucson, Arizona); Josef Vagner (Tucson, Arizona)
ABSTRACT	Provided herein are methods for identifying and treating subjects having conditions involving aberrant Ku70/80 activity. In particular, the invention relates to small-molecules which function as inhibitors of Ku70/80 protein and the non-homologous end-joining (NHEJ) pathway, and their use as therapeutics for the treatment of cancer and other diseases.
FILED	Tuesday, August 16, 2016
APPL NO	15/753513
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/496 (20130101) A61K 31/519 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 413/12 (20130101) C07D 487/04 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10308663 — Inhibitors of PTP4A3 for the treatment of cancer

US 10308663	Lazo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	John S. Lazo (Charlottesville, Virginia); Elizabeth R. Sharlow (Butler, Pennsylvania); Kelley E. McQueeney (Charlottesville, Virginia); Peter Wipf (Pittsburgh, Pennsylvania); Joseph M. Salamoun (Roanoke, Virginia)
ASSIGNEE(S)	University of Virginia Patent Foundation (Charlottesville, Virginia); University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	John S. Lazo (Charlottesville, Virginia); Elizabeth R. Sharlow (Butler, Pennsylvania); Kelley E. McQueeney (Charlottesville, Virginia); Peter Wipf (Pittsburgh, Pennsylvania); Joseph M. Salamoun (Roanoke, Virginia)
ABSTRACT	The invention provides protein tyrosine phosphatase inhibitor compounds, Their pharmaceutical compositions, uses, and methods of use, such as in the treatment of various cancers, and process for making the compounds. Also disclosed is an improved synthesis of protein tyrosine phosphatase inhibitor and precursor compound thienopyridone (5).
FILED	Thursday, June 16, 2016
APPL NO	15/737062
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4365 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 495/04 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10308682 — Inhibition of tumor growth with aggregates of small molecules

US 10308682	Xu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	BRANDEIS UNIVERSITY (Waltham, Massachusetts)
ASSIGNEE(S)	Brandeis University (Waltham, Massachusetts)
INVENTOR(S)	Bing Xu (Newton, Massachusetts); Yi Kuang (Waltham, Massachusetts)
ABSTRACT	Disclosed herein are fibrillar molecular aggregates, which are morphologically and phenotypically similar to oligomers of aberrant proteins. The molecular aggregates, formed by self-assembly of small hydrophobic molecules, prevent the growth of microtubules. This unprecedented mechanism of “self-assembly to interfere with self-organization” allows inhibition of the growth of cancer cells.
FILED	Thursday, March 06, 2014
APPL NO	14/773690
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/195 (20130101) Peptides C07K 5/06121 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10308685 — Inhibitory peptides of viral infection

US 10308685	Wall et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
ASSIGNEE(S)	UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
INVENTOR(S)	Jonathan S. Wall (Knoxville, Tennessee); Timothy E. Sparer (Knoxville, Tennessee); Stephen J. Kennel (Knoxville, Tennessee)
ABSTRACT	Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed herein are methods for blocking viral binding to a cell. Further disclosed are anti-viral compositions for administration to a subject infected with a virus. Administration of the anti-viral composition inhibits viral infection of the subject.
FILED	Thursday, May 25, 2017
APPL NO	15/605877
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) Peptides C07K 7/08 (20130101) Original (OR) Class C07K 14/001 (20130101) C07K 14/035 (20130101) C07K 14/045 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308689 — Dengue virus (DV) polypeptide sequences, T cell epitopes and methods and uses thereof

US 10308689	Shresta et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (La Jolla, California)
ASSIGNEE(S)	LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (La Jolla, California)
INVENTOR(S)	Sujan Shresta (San Diego, California); Lauren Yauch (La Jolla, California); Alessandro Sette (San Diego, California); Daniela Weiskopf (San Diego, California)
ABSTRACT	Dengue virus (DV) peptides, including T cell epitopes, structural and non-structural (NS) polypeptide sequences, subsequences and modifications thereof, nucleotide sequences encoding such peptides, and compositions including such peptides and encoding nucleotide sequences, and cells expressing such peptides, are provided. Such DV peptides, nucleotide sequences and compositions, can be used to elicit, stimulate, induce, promote, increase, enhance or activate an anti-DV CD8⁺ T cell response or an anti-DV CD4⁺ T cell response. Such peptides, nucleotide sequences and compositions can also be used for and in methods of vaccination/immunization of a subject against Dengue virus (DV) (e.g., to provide protection against DV infection and/or pathology), and for treatment of a subject in need thereof, for example, treatment of the subject for a Dengue virus (DV) infection or pathology.
FILED	Wednesday, July 15, 2015
APPL NO	14/800468
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/55566 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/00 (20130101) C07K 2319/21 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24122 (20130101) C12N 2770/24134 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308695 — Therapeutic compositions and methods for disorders associated with neuronal degeneration

US 10308695	Rex et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Telemedicine and Advanced Technology Research Center (TATRC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Tonia S. Rex (Goodlettsville, Tennessee); Timothy A. Sullivan (Savannah, Georgia)
ABSTRACT	Disclosed are isolated mutant erythropoietin (EPO) polypeptides, functional fragment thereof, nucleic acid encoding such peptides, vectors including such nucleic acids and compositions including such peptides and nucleic acids. The mutant EPO peptides are unique in that they include a substitution at amino acid position number 76, such as a glutamic acid for arginine substation at position 76. This substitution inhibits erythropoietic activity while retaining their neuroprotection. Also disclosed are methods of treating or inhibiting neuronal degeneration, reducing or inhibiting one or more symptoms associated with neuronal degeneration and/or glaucoma in a subject. The methods include administering a therapeutically effective amount of a isolated mutant erythropoietin EPO polypeptide, an expression vector encoding such a mutant erythropoietin EPO polypeptide, a viral particle including an expression vector, or a composition, thereby treating or inhibiting neuronal degeneration in the subject.
FILED	Friday, June 23, 2017
APPL NO	15/632106
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/505 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/00 (20130101) C12N 7/00 (20130101) C12N 15/00 (20130101) C12N 15/10 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308698 — Therapeutic targeting of SET1B/compass pathway for treating cancers

US 10308698	Shilatifard et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	Ali Shilatifard (Chicago, Illinois); Lu Wang (Chicago, Illinois)
ABSTRACT	Disclosed are methods for treating Set1/COMPASS-associated cancers characterized by expression of Set1B/COMPASS. The methods typically include administering a therapeutic amount of an inhibitor of the Set1B/COMPASS pathway and/or an agonist for a target that is negatively regulated by the Set1B/COMPASS pathway.
FILED	Monday, July 10, 2017
APPL NO	15/645282
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/2264 (20130101) Peptides C07K 7/06 (20130101) C07K 14/4702 (20130101) C07K 14/5759 (20130101) Original (OR) Class C07K 16/3015 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308701 — Modified glucagon molecules

US 10308701	Murphy Topp et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Elizabeth M. Murphy Topp (Lafayette, Indiana); Hamed Tabatabaei Ghomi (San Diego, California); Markus Lill (West Lafayette, Indiana); Shenbaga Moorthy Balakrishnan (Virudhunagar District, India)
ABSTRACT	The invention generally relates to modified glucagon molecules. In certain embodiments, the invention provides a glucagon molecule that includes one or more modified amino acids, e.g., phosphorylation and/or sulfation, to result in the glucagon molecule being soluble at a substantially neutral pH and resistant to fibrillation.
FILED	Friday, July 22, 2016
APPL NO	15/745483
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/26 (20130101) A61K 47/52 (20170801) Peptides C07K 14/605 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10308708 — Antibodies that neutralize botulinum neurotoxins

US 10308708	Marks et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	James D. Marks (Kensington, California); Isin N. Geren (San Francisco, California)
ABSTRACT	This disclosure provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
FILED	Tuesday, August 16, 2016
APPL NO	15/238419
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/1282 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/52 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308717 — Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor

US 10308717	Brogdon et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Novartis AG (Basel, Switzerland); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); University of Pittsburgh of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	Novartis AG (Basel, Switzerland); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); University of Pittsburgh of The Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Jennifer Brogdon (Cambridge, Massachusetts); Laura Alexandra Johnson (Ardmore, Pennsylvania); Carl H. June (Merion Station, Pennsylvania); Andreas Loew (Cambridge, Massachusetts); Marcela Maus (Bryn Mawr, Pennsylvania); John Scholler (Narberth, Pennsylvania); Hideho Okada (Pittsburgh, Pennsylvania)
ABSTRACT	The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.
FILED	Wednesday, June 15, 2016
APPL NO	15/182775
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/2863 (20130101) Original (OR) Class C07K 16/3053 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/73 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308718 — Anti-sortilin antibodies and methods of use thereof

US 10308718	Rosenthal et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	ALECTOR LLC (South San Francisco, California)
ASSIGNEE(S)	ALECTOR LLC (South San Francisco, California)
INVENTOR(S)	Arnon Rosenthal (Woodside, California); Tina Schwabe (San Francisco, California); Michael Kurnellas (San Francisco, California); Robert Pejchal (Norwich, Vermont); Anthony B. Cooper (White River Junction, Vermont)
ABSTRACT	The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.
FILED	Wednesday, January 10, 2018
APPL NO	15/867609
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Peptides C07K 16/286 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/21 (20130101) C07K 2317/31 (20130101) C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2319/30 (20130101) C07K 2319/32 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308774 — Polycarbonate containing compounds and methods related thereto

US 10308774	Harth et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Eva M. Harth (Nashville, Tennessee); David M. Stevens (Nashville, Tennessee)
ABSTRACT	Disclosed herein are crosslinked polycarbonates, composition thereof and methods thereof. The crosslinked polycarbonates can be prepared from allyl or epoxy polycarbonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED	Monday, February 27, 2017
APPL NO	15/443456
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/19 (20130101) A61K 9/5146 (20130101) A61K 9/5192 (20130101) A61K 47/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) A61L 31/06 (20130101) A61L 31/16 (20130101) A61L 31/146 (20130101) A61L 2300/412 (20130101) A61L 2300/416 (20130101) A61L 2400/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/34 (20130101) C08G 59/66 (20130101) C08G 59/504 (20130101) C08G 64/42 (20130101) C08G 64/0216 (20130101) C08G 64/0241 (20130101) C08G 64/0291 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 3/246 (20130101) Original (OR) Class C08J 2369/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/37 (20130101) Compositions of Macromolecular Compounds C08L 69/00 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308911 — Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells

US 10308911	Hashino et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S)	Indiana University Research and Technology Corporation (Indianapolis, Indiana)
ASSIGNEE(S)	Indiana University Research and Technology Corporation (Indianapolis, Indiana)
INVENTOR(S)	Eri Hashino (Indianapolis, Indiana); Gerry Oxford (Indianapolis, Indiana); Karl R. Koehler (Indianapolis, Indiana)
ABSTRACT	Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating TGFβ, BMP, and FGF signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal tissues from pluripotent stem cells. Methods for identifying agents that induce or enhance differentiation and generation of hair cells are also disclosed. Methods for identifying cytoprotective agents for hair cells are also described.
FILED	Wednesday, March 01, 2017
APPL NO	15/446552
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/062 (20130101) C12N 5/0627 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/113 (20130101) C12N 2501/115 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101) C12N 2506/03 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) G01N 33/5073 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308926 — Stablized EZH2 peptides

US 10308926	Walensky et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S)	Loren D. Walensky (Newton, Massachusetts); Gregory H. Bird (Pelham, New Hampshire); Woojin Kim (Newton, Massachusetts); Stuart Orkin (Brookline, Massachusetts)
ABSTRACT	Provided herein are polypeptides containing stabilized therapeutic peptides related to enhancer of zeste homolog 2 (EZH2), histone lysine N-methyltransferase. Also provided are compositions containing these polypeptides and methods of using such peptides in the treatment of cancer that include administering to a subject one of the polypeptides.
FILED	Thursday, March 13, 2014
APPL NO	14/772143
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/96 (20130101) Original (OR) Class C12N 9/1007 (20130101) Enzymes C12Y 201/01043 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308933 — Methods for diagnosing and treating learning or mental disorders

US 10308933	Zakharenko et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	St. Jude Children's Research Hospital (Memphis, Tennessee)
ASSIGNEE(S)	ST. JUDE CHILDREN'S RESEARCH HOSPITAL (Memphis, Tennessee)
INVENTOR(S)	Stanislav S. Zakharenko (Collierville, Tennessee); Laurie R. Earls (Memphis, Tennessee)
ABSTRACT	The present invention embraces methods for the diagnosis and treatment of learning or mental disorders such as schizophrenia using miR-25, miR-98, or miR-185.
FILED	Wednesday, December 30, 2015
APPL NO	14/984045
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2320/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308939 — Use of an miRNA to reduce proliferation of a cancer cell

US 10308939	Peruzzi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana)
ASSIGNEE(S)	BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY (Baton Rouge, Louisiana)
INVENTOR(S)	Francesca Peruzzi (New Orleans, Louisiana); Duane Jeansonne (New Orleans, Louisiana)
ABSTRACT	A method is provided for decreasing at least one of the proliferation and the migration of a cancer cell comprising contacting a cancer cell with an effective amount of a pharmaceutically acceptable composition comprising a microRNA (miRNA) having a nucleotide sequence having at least 80% sequence similarity to the nucleotide sequence of miR-3189-3p derived from the miR-3189 mitron of the Growth Differentiation Factor 15 (GDF15) gene. The methods and compositions are advantageous for inhibiting proliferation and migration of, but not limited to, glioblastoma cells, melanoma cells, and breast cancer cells.
FILED	Thursday, January 25, 2018
APPL NO	15/880032
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/7125 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1135 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/141 (20130101) C12N 2330/10 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308942 — Methods and compositions for treating autoimmune disorders by targeting Kv1.3 ion channels with functionalized lipid-derived nanovesicles

US 10308942	Conforti et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	University of Cincinnati (Cincinnati, Ohio); North Carolina Agricultural and Technical State University (Greensboro, North Carolina)
ASSIGNEE(S)	University of Cincinnati (Cincinnati, Ohio); North Carolina Agricultural and Technical State University (Greensboro, North Carolina)
INVENTOR(S)	Laura Conforti (Wyoming, Ohio); Yeoheung Yun (Greensboro, North Carolina)
ABSTRACT	Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased expression and/or hyperactivity of T cells by selectively targeting memory T cells with the nanoparticles, which deliver their siRNA cargo into the cytosol of the T_Mcell thus reducing ion channel expression and decreasing Ca²⁺ influx.
FILED	Tuesday, August 22, 2017
APPL NO	15/683180
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1272 (20130101) A61K 31/713 (20130101) A61K 47/6913 (20170801) Peptides C07K 16/289 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2320/32 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308946 — Expression cassette for transformation comprising a modified viral sequence driven by a suitable promoter

US 10308946	Rasochova et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Lada Rasochova (Madison, Wisconsin); Thomas German (Hollandale, Wisconsin); Paul Ahlquist (Madison, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	Lada Rasochova (Madison, Wisconsin); Thomas German (Hollandale, Wisconsin); Paul Ahlquist (Madison, Wisconsin)
ABSTRACT	Disclosed herein are novel methods and materials directed to transforming a host cell and expressing exogenous RNA therein. Specifically disclosed are DNA-launching platforms used to introduce a replicating viral segment attached to an exogenous polynucleotide into a cell, whereby the exogenous polynucleotide is expressed in said cell and confers a detectable trait.
FILED	Wednesday, January 10, 2007
APPL NO	11/621850
ART UNIT	1662 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8203 (20130101) Original (OR) Class C12N 15/8205 (20130101) C12N 15/8216 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308957 — rAAV vectors and methods for transduction of photoreceptors and RPE cells

US 10308957	Boye et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
INVENTOR(S)	Shannon E. Boye (Gainesville, Florida); Sanford L. Boye (Gainesville, Florida); Mavis Agbandje-McKenna (Gainesville, Florida); Arun Srivastava (Gainesville, Florida)
ABSTRACT	Disclosed are capsid-modified rAAV particles and expression vectors, as well as compositions and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and using novel capsid-protein-mutated particle or rAAV vector constructs in a variety of diagnostic and therapeutic applications including, inter alia, as delivery agents for diagnosis, treatment, or amelioration of one or more diseases, disorders, or dysfunctions of the mammalian eye. Also disclosed are methods for subretinal delivery of therapeutic gene constructs to mammalian photoreceptors and retinal pigment epithelial cells, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications including the treatment of a variety of inherited retinal diseases.
FILED	Wednesday, March 04, 2015
APPL NO	15/123515
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 9/5184 (20130101) A61K 48/00 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2810/6027 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308959 — Methods, systems, and compositions relating to MiRNA-146a

US 10308959	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Henry Ford Health System (Detroit, Michigan)
ASSIGNEE(S)	Henry Ford Health System (Detroit, Michigan)
INVENTOR(S)	Xianshuang Liu (Troy, Michigan); Zhenggang Zhang (Troy, Michigan); Michael Chopp (Southfield, Michigan); Lei Wang (Troy, Michigan); Benjamin A. L. Buller (Bloomfield Hills, Michigan)
ABSTRACT	Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or neurological outcome or function in a patient in need thereof. Some embodiments also comprise the administration a composition comprising a pharmaceutically effective amount of one or more of a group comprising microRNA-146a, exosomes comprising microRNA-146a, a promoter of microRNA-146a expression, a microRNA-146a thymosin beta 4, and a phosphodiesterase 5 inhibitor to treat neurological conditions, diseases, or injuries in mammals, including in human beings.
FILED	Friday, May 19, 2017
APPL NO	15/600567
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 35/12 (20130101) A61K 35/15 (20130101) A61K 35/30 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) C12N 15/00 (20130101) C12N 15/11 (20130101) C12N 15/87 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308960 — Methods for treating cells containing fusion genes

US 10308960	Luo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Pittsburgh of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh - of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Jianhua Luo (Wexford, Pennsylvania); Yanping Yu (Wexford, Pennsylvania); Zhanghui Chen (Pittsburgh, Pennsylvania); George Konstantine Michalopoulos (Pittsburgh, Pennsylvania); Joel Nelson (Pittsburgh, Pennsylvania)
ABSTRACT	The present invention relates to methods for treating prostate cancer patients. It is based, at least in part, on the discovery that approximately 90% of men carrying at least one of the following fusion genes: TRMT11-GRIK2, SLC45A2-AMACR, MTOR-TP53BP1, LRRC59-FLJ60017, TMEM135-CCDC67 and CCNH-05orf30 experienced prostate cancer recurrence, metastases and/or prostate cancer-specific death after radical prostatectomy (each examples of “progressive prostate cancer”), while these outcomes occurred in only 36% of men not carrying any of these fusion genes. It is also based, at least in part, on the discovery that a genome editing technique that specifically targets a fusion gene can induce cell death in a cancer cell that carries the fusion gene.
FILED	Friday, January 13, 2017
APPL NO	15/406472
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) A61K 38/1761 (20130101) A61K 48/0058 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1211 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/111 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/10 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 207/01021 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308982 — Spatially encoded biological assays

US 10308982	Chee
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Prognosys Biosciences, Inc. (San Diego, California)
ASSIGNEE(S)	Prognosys Biosciences, Inc. (San Diego, California)
INVENTOR(S)	Mark S. Chee (San Diego, California)
ABSTRACT	The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.
FILED	Monday, June 20, 2016
APPL NO	15/187661
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6809 (20130101) C12Q 1/6809 (20130101) C12Q 1/6834 (20130101) C12Q 1/6834 (20130101) C12Q 1/6837 (20130101) Original (OR) Class C12Q 1/6837 (20130101) C12Q 1/6841 (20130101) C12Q 1/6841 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 2535/122 (20130101) C12Q 2535/122 (20130101) C12Q 2535/122 (20130101) C12Q 2535/122 (20130101) C12Q 2543/10 (20130101) C12Q 2543/10 (20130101) C12Q 2543/10 (20130101) C12Q 2543/10 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101) C12Q 2565/515 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) C40B 60/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) G01N 33/6845 (20130101) G01N 2458/10 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308985 — Methods for diagnosing risk of renal allograft fibrosis and rejection

US 10308985	Murphy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Icahn School of Medicine at Mount Sinai (New York, New York)
ASSIGNEE(S)	Icahn School of Medicine at Mount Sinai (New York, New York)
INVENTOR(S)	Barbara Murphy (Pelham Manor, New York); Weijia Zhang (Cresskill, New Jersey)
ABSTRACT	Disclosed herein is a method for diagnosing a renal allograft recipient's risk for developing fibrosis of the allograft and allograft loss. The method includes determining the expression levels of certain microRNAs, which have been determined to be predictive of an allograft recipient's risk. Also disclosed herein is a method of treating a renal allograft recipient to inhibit fibrosis of the allograft and allograft loss, as well as kits for use in the methods disclosed herein.
FILED	Friday, June 26, 2015
APPL NO	15/320208
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/343 (20130101) A61K 31/436 (20130101) A61K 31/573 (20130101) A61K 31/4412 (20130101) A61K 31/5377 (20130101) A61K 38/13 (20130101) A61K 38/18 (20130101) A61K 38/1774 (20130101) A61K 38/1875 (20130101) A61K 38/2221 (20130101) Peptides C07K 14/70521 (20130101) C07K 2319/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/52 (20130101) G01N 2800/245 (20130101) G01N 2800/347 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308986 — Cancer diagnosis, treatment selection and treatment

US 10308986	Szallasi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); THE TECHNICAL UNIVERSITY OF DENMARK (Lyngby, Denmark)
ASSIGNEE(S)	CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); THE TECHNICAL UNIVERSITY OF DENMARK, KGS (Lyngby, Denmark)
INVENTOR(S)	Zoltan I. Szallasi (Boston, Massachusetts); Andrea L. Richardson (Chestnut Hill, Massachusetts); Nicolai J. Birkbak (København Ø, Denmark); Zhigang Wang (Newton, Massachusetts)
ABSTRACT	The present invention provides assays, methods and systems for selecting an effective therapy for a subset of cancer patients having cancer cells with increased expression of BML and FANCI genes and/or having copy number increase in chromosome location 15q26 in the cancer cells and for treatment of such patients with the effective therapy of cancer patients based on the personalized cancer cell expression profile.
FILED	Thursday, March 13, 2014
APPL NO	14/774772
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 33/24 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309879 — Expansion microscopy

US 10309879	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Fei Chen (Cambridge, Massachusetts); Paul Warren Tillberg (Cambridge, Massachusetts); Edward Stuart Boyden (Chestnut Hill, Massachusetts)
ABSTRACT	The present invention relates to an enlarged sample of interest for microscopy and methods for enlarging a sample of interest and the optical imaging of a sample of interest with resolution better than the classical microscopy diffraction limit, by synthesizing a swellable polymer network within a sample, it can be physically expanded, resulting in physical magnification.
FILED	Friday, February 20, 2015
APPL NO	14/627310
ART UNIT	1678 — Semiconductors/Memory
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 1/36 (20130101) Original (OR) Class G01N 2001/364 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0072 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309881 — Methods and apparatus for preparing aqueous specimens for electron microscopy using volatile surfactants

US 10309881	Glaeser et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Robert M. Glaeser (Berkeley, California); Bong-Gyoon Han (Castro Valley, California)
ABSTRACT	This disclosure provides systems, methods, and apparatus related to the preparation of electron microscopy specimens. In one aspect, a method includes providing an electron microscopy grid. An aqueous suspension including an electron microscopy sample is deposited on the electron microscopy grid. A portion of the aqueous suspension is removed from the electron microscopy grid. A volatile surfactant is contacted to the aqueous suspension. A thickness of aqueous suspension is allowed to decrease over a period of time. The aqueous suspension is then frozen.
FILED	Tuesday, June 28, 2016
APPL NO	15/194777
ART UNIT	2881 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 1/42 (20130101) Original (OR) Class G01N 1/405 (20130101) G01N 2001/4061 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309902 — Characterization of trace crystallinity by second harmonic generation microscopy

US 10309902	Simpson et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) Food and Drug Administration (FDA) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
INVENTOR(S)	Garth Jason Simpson (West Lafayette, Indiana); Paul David Schmitt (Zionsville, Indiana)
ABSTRACT	A method for quantifying crystallinity within a sample using second harmonic generation microscopy is described herein. In one aspect, a method for reducing the timeframe for accelerated stability testing of amorphous solid dispersions of active pharmaceutical ingredients though identifying regions of interest to quantify crystallinity and composition is presented herein.
FILED	Monday, September 28, 2015
APPL NO	15/514893
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Original (OR) Class G01N 21/636 (20130101) G01N 23/207 (20130101) G01N 2223/606 (20130101) G01N 2223/612 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309960 — Label-free detection of nanoparticles and biological molecules using microtoroid optical resonatiors

US 10309960	Su
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Research Service Award (NRSA)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S)	Tsu-Te Judith Su (Pasadena, California)
ABSTRACT	Systems and methods are provided for detecting one or more particles such as individual unlabeled molecules or single nanoparticles. In examples described herein, optical energy is introduced into a microtoroid or other microcavity to generate an evanescent field. The microcavity has a functionalized outer surface that has been functionalized with a chemically or biologically active substance such as an antibody, antigen or protein. An indication of a particle bound to the functionalized outer surface of the microcavity is then detected based on a reactive interaction between the particle and the evanescent field while using frequency locking, balanced detection and various filtering techniques. The frequency locking, balanced detection and filtering techniques reduce the signal-to-noise ratio (SNR) of the detection system so that single nanoparticles (e.g. 2.5 nanometers (nm) in radius) and individual molecules (e.g. 15.5 kilo-Dalton (kDa) in size) can be detected in aqueous solution in some examples.
FILED	Saturday, July 08, 2017
APPL NO	15/644772
ART UNIT	2877 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) G01N 21/7746 (20130101) G01N 33/54313 (20130101) G01N 33/54373 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10309974 — Citrullinated proteins: a post-translated modification of myocardial proteins as marker of physiological and pathological disease

US 10309974	Fert-Bober et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Cedars-Sinai Medical Center (Los Angeles, California)
ASSIGNEE(S)	CEDARS-SINAI MEDICAL CENTER (Los Angeles, California)
INVENTOR(S)	Justyna P. Fert-Bober (Sherman Oaks, California); Jennifer E. Van Eyk (Los Angeles, California)
ABSTRACT	Disclosed herein are methods for diagnosing cardiovascular disease. The methods comprise detection of citrullinated proteins and/or citrullinated peptides. Also disclosed herein are methods, compositions, and kits for diagnosing and/or treating cardiovascular disease.
FILED	Wednesday, November 15, 2017
APPL NO	15/814200
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 33/6812 (20130101) G01N 33/6848 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2440/18 (20130101) G01N 2800/32 (20130101) G01N 2800/50 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10310031 — System and method for reducing specific absorption rate in magnetization transfer magnetic resonance imaging

US 10310031	Guerin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Bastien Guerin (Cambridge, Massachusetts); Lawrence L Wald (Cambridge, Massachusetts)
ABSTRACT	Described here are a system and method for designing radio frequency (“RF”) pulses for parallel transmission (“pTx”) applications, and particularly pTx applications in magnetization transfer (“MT”) magnetic resonance imaging (“MRI”). The concept of “SAR hopping” is implemented using a constrained optimization problem that simultaneously designs multiple RF sub-pulses to maximize power deposition in a bound proton pool while also minimizing local SAR across multiple bound proton pool excitation frequencies. This results in the set of RF waveforms that yield the best excitation profiles for all pulses while ensuring that the local SAR of the average of all pulses is below the regulatory limit imposed by the FDA. Pulses are designed simultaneously while constraining local SAR, global SAR, and peak voltage, explicitly.
FILED	Thursday, November 03, 2016
APPL NO	15/342205
ART UNIT	2868 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/288 (20130101) Original (OR) Class G01R 33/5605 (20130101) G01R 33/5612 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10310042 — Hierrarchical mapping framework for coil compression in magnetic resonance image reconstruction

US 10310042	Cauley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Mental Health (NIMH)
APPLICANT(S)	THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Stephen Cauley (Cambridge, Massachusetts); Jonathan Polimeni (Cambridge, Massachusetts); Kawin Setsompop (Cambridge, Massachusetts); Lawrence Wald (Cambridge, Massachusetts)
ABSTRACT	Systems and methods for a hierarchical mapping framework (“HMF”} for coil compression are provided. The HMF-based coil compression can be applied to existing coil compression algorithms to improve their performance. The receive channels associated with a coil array are divided into subgroups based on the strength of their mutual correlation. In each subgroup, one or more virtual channels are produced based on the channels not in the subgroup. The virtual channels are produced using a coil compression algorithm subject to a hierarchically semiseparable channel mixing across the subgroups. Images are reconstructed for the subgroups and then combined to produce the final image of the subject.
FILED	Thursday, April 23, 2015
APPL NO	15/305436
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/7246 (20130101) A61B 5/7285 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/482 (20130101) G01R 33/3664 (20130101) G01R 33/4824 (20130101) G01R 33/5608 (20130101) G01R 33/5611 (20130101) G01R 33/5612 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10310047 — Systems and methods for free-breathing cine DENSE MRI using self-navigation

US 10310047	Cai et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia)
ASSIGNEE(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
INVENTOR(S)	Xiaoying Cai (Charlottesville, Virginia); Frederick H. Epstein (Charlottesville, Virginia); Xiaodong Zhong (Marietta, Georgia)
ABSTRACT	Some aspects of the present disclosure relate to systems and methods for free-breathing cine DENSE MRI using self-navigation. In one embodiment, a method includes acquiring magnetic resonance data for an area of interest of a subject, wherein the acquiring comprises performing sampling with phase-cycled, cine displacement encoding with stimulated echoes (DENSE) during free-breathing of the subject; identifying, from the acquired magnetic resonance data, a plurality of phase-cycling data pairs corresponding to matched respiratory phases of the free-breathing of the subject; reconstructing, from the plurality of phase-cycling data pairs, a plurality of intermediate self-navigation images; performing motion correction by estimating, from the plurality of intermediate self-navigation images, the respiratory position associated with the plurality of phase-cycling data pairs; and reconstructing a plurality of motion-corrected cine DENSE images of the area of interest of the subject.
FILED	Friday, April 21, 2017
APPL NO	15/493825
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/561 (20130101) G01R 33/5676 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10311598 — Fully automated localization of electroencephalography (EEG) electrodes

US 10311598	Rodriguez et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, None)
INVENTOR(S)	Cameron Rodriguez (Santa Monica, California); Mark Cohen (Calabasas, California)
ABSTRACT	A method for fully automated localization and channel identification of electroencephalography (EEG) electrodes. The electrode locations are automatically identified from three dimensional images stored in an electronic format, wherein the images may be derived from magnetic resonance imaging (MRI) that render the electrodes visible and object shapes and properties are used to locate the electrodes in the three dimensional images. The three dimensional images also show the brain in detail, such that the relationship of the electrodes to the brain is available, thereby making it possible to better identify electrical sources within the brain that create the EEG signals.
FILED	Friday, May 16, 2014
APPL NO	14/280537
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/74 (20170101) Original (OR) Class G06T 15/08 (20130101) G06T 2200/04 (20130101) G06T 2207/10088 (20130101) G06T 2207/30016 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

RE047415 — Pyrimidinecarboxamides as CXCR2 modulators

US RE47415	Maeda et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Syntrix Biosystems Inc. (Auburn, Washington)
ASSIGNEE(S)	Syntrix Biosystems, Inc. (Auburn, Washington)
INVENTOR(S)	Dean Y. Maeda (Seattle, Washington); John A. Zebala (Issaquah, Washington)
ABSTRACT	There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.
FILED	Thursday, March 16, 2017
APPL NO	15/461278
ART UNIT	3991 — Central Reexamination Unit (Chemical)
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/69 (20130101) A61K 31/444 (20130101) A61K 31/4439 (20130101) Heterocyclic Compounds C07D 213/82 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 413/12 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Defense (DOD)

10307340 — Devices for clearing blockages in artificial and natural lumens

US 10307340	Bagwell et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Science Foundation (NSF)
APPLICANT(S)	Actuated Medical, Inc. (Bellefonte, Pennsylvania)
ASSIGNEE(S)	Actuated Medical, Inc. (Bellefonte, Pennsylvania)
INVENTOR(S)	Roger B Bagwell (Bellefonte, Pennsylvania); Ryan S Clement (State College, Pennsylvania); Katherine M Erdley (Boalsburg, Pennsylvania); Maureen L Mulvihill (Bellefonte, Pennsylvania); Casey A Scruggs (Middleburg, Pennsylvania); Douglas R Dillon (Port Matilda, Pennsylvania); Timothy J Higgins (Mingoville, Pennsylvania)
ABSTRACT	An occlusion clearing device for a patient has a housing with a motor(s) that generates repetitive motion, which is reciprocating, rotational or both. A clearing stem including a sheath that has a lumen, wherein aspiration is conducted through the sheath lumen. A wire is located in the sheath lumen and receives repetitive motion from the controller. The sheath terminates in a sheath end having at least one sheath opening. The wire terminates in a wire tip, which may be flat, helical, or tubular. The wire tip is positioned within the sheath end, in proximity to the sheath opening(s), and movement of the wire tip and/or sheath end relative to each other creates shearing forces that break up an adjacent occlusion.
FILED	Friday, July 29, 2016
APPL NO	15/223787
ART UNIT	3781 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/22 (20130101) A61B 17/3207 (20130101) A61B 17/22012 (20130101) A61B 17/320758 (20130101) A61B 17/320783 (20130101) A61B 90/70 (20160201) A61B 2017/00477 (20130101) A61B 2017/00685 (20130101) A61B 2017/00876 (20130101) A61B 2017/22014 (20130101) A61B 2017/22079 (20130101) A61B 2017/320012 (20130101) A61B 2017/320028 (20130101) A61B 2017/320733 (20130101) A61B 2017/320775 (20130101) A61B 2090/034 (20160201) A61B 2090/701 (20160201) A61B 2217/005 (20130101) A61B 2217/007 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 15/0003 (20130101) A61J 15/0026 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/0084 (20130101) A61M 3/0279 (20130101) A61M 25/00 (20130101) A61M 25/0082 (20130101) A61M 39/00 (20130101) A61M 2025/0019 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307388 — Compositions and methods for diagnosis and treatment of inflammation

US 10307388	Venn-Watson
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Stephanie Kay Venn-Watson (San Diego, California)
ABSTRACT	Compositions including an fatty acid, such as an odd chain fatty acid or a very long even chain fatty acid, and salts and derivatives thereof, and methods for treatment and prophylaxis of conditions related to inflammation and conditions related to inflammation, including anemia of chronic disease, insulin resistance, metabolic syndrome, autoimmune disease, hypertension, diabetes, nonalcoholic fatty liver disease, cardiovascular disease, cancer, aging, neurodegenerative diseases, including Alzheimer's disease and other forms of dementia, and other related conditions, and other related conditions.
FILED	Thursday, December 29, 2016
APPL NO	15/393799
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/20 (20130101) Original (OR) Class A61K 31/20 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307477 — Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment

US 10307477	Tomaka et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
APPLICANT(S)	Janssen Vaccines and Prevention B.V. (Leiden, Netherlands); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc (Bethesda, Maryland); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY (Fort Datrick, Maryland)
ASSIGNEE(S)	Janssen Vaccines and Prevention B.V. (Leiden, Netherlands); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The United States of America, as represented by The Secretary Of The Army (Washington, District of Columbia)
INVENTOR(S)	Frank Tomaka (Titusville, New Jersey); Maria Grazia Pau (Leiden, Netherlands); Johanna Schuitemaker (Amstelveen, Netherlands); Dan Barouch (Newton, Massachusetts); Jintanat Ananworanich (Rockville, Maryland); Merlin Robb (Silver Spring, Maryland); Nelson L. Michael (Silver Spring, Maryland); Jerome Kim (Silver Spring, Maryland)
ABSTRACT	Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.
FILED	Friday, September 01, 2017
APPL NO	15/693650
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 2039/57 (20130101) A61K 2039/70 (20130101) A61K 2039/545 (20130101) A61K 2039/575 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10043 (20130101) C12N 2710/10343 (20130101) C12N 2710/24043 (20130101) C12N 2710/24143 (20130101) C12N 2740/16021 (20130101) C12N 2740/16034 (20130101) C12N 2740/16134 (20130101) C12N 2740/16171 (20130101) C12N 2740/16234 (20130101) C12N 2740/16271 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307515 — In situ forming hemostatic foam implants

US 10307515	Sharma et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	ARSENAL MEDICAL, INC. (Watertown, Massachusetts)
ASSIGNEE(S)	Arsenal Medical Inc. (Watertown, Massachusetts)
INVENTOR(S)	Upma Sharma (Somerville, Massachusetts); Irina Gitlin (Brookline, Massachusetts); Gregory T. Zugates (Chelmsford, Massachusetts); Adam Rago (Falmouth, Massachusetts); Parisa Zamiri (Brookline, Massachusetts); Rany Busold (Medford, Massachusetts); Robert J. Caulkins (Watertown, Massachusetts); Toby Freyman (Lexington, Massachusetts); Quynh Pham (Methuen, Massachusetts); Changcheng You (Northbridge, Massachusetts); Jeffrey Carbeck (Belmolnt, Massachusetts)
ABSTRACT	Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
FILED	Friday, October 30, 2015
APPL NO	14/928857
ART UNIT	3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/12031 (20130101) A61B 17/12163 (20130101) A61B 17/12186 (20130101) A61B 2017/12004 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/2093 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/18 (20130101) A61L 27/18 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 31/06 (20130101) Original (OR) Class A61L 31/06 (20130101) A61L 31/141 (20130101) A61L 31/146 (20130101) A61L 31/148 (20130101) A61L 2400/04 (20130101) A61L 2400/06 (20130101) A61L 2400/18 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/00 (20130101) Compositions of Macromolecular Compounds C08L 63/00 (20130101) C08L 63/00 (20130101) C08L 67/04 (20130101) C08L 67/04 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307592 — Method and system to accelerate consolidation of specific memories using transcranial stimulation

US 10307592	Pilly et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Praveen K. Pilly (West Hills, California); Michael D. Howard (Westlake Village, California); Jaehoon Choe (Agoura Hills, California); Rajan Bhattacharyya (Sherman Oaks, California)
ABSTRACT	Described is a system for consolidation of specific memories of events. A sleep state detector assesses a subject's sleep state from neural recordings obtained from a high-density electroencephalogram (HD-EEG) device. During a memory encoding phase, a high-definition transcranial current stimulation (HD-tCS) system simultaneously applies a spatiotemporal amplitude-modulated pattern (STAMP) tag and a transcranial direct current stimulation (tDCS) signal to the subject as an event is experienced by the subject. During a memory consolidation phase, the HD-tCS system applies a transcranial alternating current stimulation (tACS) signal to the subject during a sleep or quiet waking state of the subject.
FILED	Monday, October 24, 2016
APPL NO	15/332787
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0476 (20130101) A61B 5/4812 (20130101) A61B 5/4836 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/20 (20130101) A61N 1/36025 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10307746 — Palladium hydride nanomaterials

US 10307746	Duan et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Xiangfeng Duan (Los Angeles, California); Yu Huang (Los Angeles, California); Zipeng Zhao (Los Angeles, California); Xiaoqing Huang (Los Angeles, California)
ABSTRACT	A palladium hydride nanomaterial includes nanostructures having a chemical composition represented by the formula: M_y-Pd_xH_z, where M is at least one metal different from palladium; x has a non-zero value in the range of 0 to 5; y has a value in the range of 0 to 5; and z has a non-zero value in the range of 0 to 5.
FILED	Friday, August 21, 2015
APPL NO	15/505454
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/121 (20130101) Original (OR) Class B01J 35/0013 (20130101) B01J 37/04 (20130101) B01J 37/06 (20130101) B01J 37/009 (20130101) B01J 37/0072 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/0026 (20130101) C01B 3/0031 (20130101) C01B 6/02 (20130101) C01B 6/24 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307803 — Transmission window cleanliness for directed energy devices

US 10307803	Bantell et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	SPAWAR System Center Pacific (San Diego, California)
ASSIGNEE(S)	The United States of America as represented by Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Frank Joseph Bantell (Honolulu, Hawaii); Nackieb M. Kamin (Kapolei, Hawaii)
ABSTRACT	A system and method are disclosed for cleanliness of transmission windows for directed energy devices. A positive pressure gas chamber is fixed to the transmission window of a directed energy device, e.g., a laser or high power microwave. A gas source is connected to the positive pressure chamber in order to provide pressurized gas. The gas flows into the positive pressure chamber, and exits the positive pressure chamber through openings, thus pushing particulates out of the positive pressure chamber. The gas continues to flow during directed energy use, thus preventing undesirable material, e.g., dirt and moisture, from depositing on the transmission window.
FILED	Wednesday, July 20, 2016
APPL NO	15/215416
ART UNIT	1711 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Cleaning in General; Prevention of Fouling in General B08B 5/02 (20130101) B08B 15/04 (20130101) B08B 17/02 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 27/0006 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307851 — Techniques for providing stop-offs for brazing materials or other materials on structures being joined

US 10307851	Pentland et al.
FUNDED BY	Department of Defense (DOD) Missile Defense Agency (MDA)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Christopher E. Pentland (Vail, Arizona); Ryan J. Reeser (Oro Valley, Arizona); Desirée L. Schaub (Tucson, Arizona)
ABSTRACT	A method includes obtaining multiple components to be coupled together, such as during a brazing operation. At least one of the multiple components includes a stop-off. The stop-off includes one or more markings formed on at least one surface of the at least one component. The one or more markings include (i) one or more etches in the at least one surface and/or (ii) one or more oxides formed by localized heating of the at least one surface. The method also includes coupling the multiple components together using a melted or liquid material, such as a filler metal used in the brazing operation. The stop-off controls or interrupts a flow of the melted or liquid material in a joint between the multiple components during the coupling. The one or more markings could interfere with a capillary action that pulls the melted or liquid material into the joint.
FILED	Wednesday, December 14, 2016
APPL NO	15/379252
ART UNIT	1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0012 (20130101) B23K 1/20 (20130101) Original (OR) Class B23K 26/355 (20180801) B23K 26/364 (20151001) B23K 37/06 (20130101) B23K 2101/06 (20180801)
VIEW PATENT	@ USPTO: Full Text PDF

10307959 — Concrete delivery system

US 10307959	Northrup et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia)
INVENTOR(S)	Gerald R. Northrup (Champaign, Illinois); William Jacob Wagner (Champaign, Illinois); Megan A. Kreiger (Champaign, Illinois); Bruce A. MacAllister (Mahomet, Illinois); Michael Patrick Case (Mahomet, Illinois); Ghassan Al-Chaar (Champaign, Illinois)
ABSTRACT	The present invention is a three-dimensional printing system which is capable of printing with multiple different printing materials, including homogenous materials, such as cement paste, or heterogeneous materials, such as concrete. Functionality is accomplished by novel, critical structures including but not limited to a movable gate capable of controlling the flow of printing materials without clogging or becoming otherwise damaged. The system has a print head that discharges printing material through a discharge aperture. The movable gate is rotatably connected to the print head, allowing it to cover the discharge aperture and cut off the flow of printing material when actuated and rotated into position. Certain embodiments also include hose positioning systems to prevent hoses delivering printing material from disconnecting or damaging the printed structure.
FILED	Thursday, September 29, 2016
APPL NO	15/280967
ART UNIT	1744 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/321 (20170801) B29C 64/343 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) Scaffolding; Forms; Shuttering; Building Implements or Aids, or Their Use; Handling Building Materials on the Site; Repairing, Breaking-up or Other Work on Existing Buildings E04G 21/00 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308002 — Bondline control adhesive spacer

US 10308002	Nguyen et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Thompson Nguyen (Tukwila, Washington); Michael W. Evens (Burren, Washington); Michael S. Goodrich (Long Beach, California); Lindsay R. Calhoun (Norman, Oklahoma); Richard A. Binder (Hermosa Beach, California)
ABSTRACT	Disclosed herein is a method of bonding a first part to a second part to form an assembly. The method includes positioning a plurality of adhesive spacers between the first part and the second part. Each adhesive spacer is made of a first curable adhesive in a cured state. The method further includes positioning at least one adhesive layer between the plurality of adhesive spacers and the first part and between the plurality of adhesive spacers and the second part. Each adhesive layer is made of the same first curable adhesive as the plurality of adhesive spacers, but in a non-cured state. The method further includes with the plurality of adhesive spacers between the first part, the second part, and the adhesive layers, curing the first part, the second part, and the adhesive layers.
FILED	Tuesday, May 23, 2017
APPL NO	15/603200
ART UNIT	1781 — Miscellaneous Articles, Stock Material
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/12 (20130101) B32B 37/12 (20130101) Original (OR) Class B32B 37/1018 (20130101) B32B 38/0004 (20130101) B32B 2305/72 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308504 — Hierarchical micro assembler system

US 10308504	Lu et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
INVENTOR(S)	Jeng Ping Lu (Fremont, California); Eugene M. Chow (Palo Alto, California); David K. Biegelsen (Portola Valley, California); Sourobh Raychaudhuri (Mountain View, California)
ABSTRACT	A method of manufacturing and using micro assembler systems are described. A method of manufacturing includes disposing a first plurality of electrodes above a first zone of the substrate, wherein the first plurality of electrodes has a first range of spacing. The method further includes disposing a second plurality of electrodes above a second zone of the substrate, wherein the second plurality of electrodes has a second range of spacing that is less than the first range of spacing. A method of using micro assembler systems includes disposing a mobile particle at least partially submersed in an assembly medium above a substrate, a first plurality of electrodes and a second plurality of electrodes. The method further includes conducting a field through individual electrodes of the first plurality of electrodes and the second plurality of electrodes to generate electrophoretic forces or dielectrophoretic forces on the mobile particle.
FILED	Friday, March 31, 2017
APPL NO	15/476843
ART UNIT	2898 — Semiconductors/Memory
CURRENT CPC	Microstructural Devices or Systems, e.g Micromechanical Devices B81B 2207/05 (20130101) B81B 2207/056 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00015 (20130101) B81C 1/00031 (20130101) Original (OR) Class B81C 2201/0149 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/06 (20130101) H01L 21/027 (20130101) H01L 29/0665 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308695 — Therapeutic compositions and methods for disorders associated with neuronal degeneration

US 10308695	Rex et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Telemedicine and Advanced Technology Research Center (TATRC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Tonia S. Rex (Goodlettsville, Tennessee); Timothy A. Sullivan (Savannah, Georgia)
ABSTRACT	Disclosed are isolated mutant erythropoietin (EPO) polypeptides, functional fragment thereof, nucleic acid encoding such peptides, vectors including such nucleic acids and compositions including such peptides and nucleic acids. The mutant EPO peptides are unique in that they include a substitution at amino acid position number 76, such as a glutamic acid for arginine substation at position 76. This substitution inhibits erythropoietic activity while retaining their neuroprotection. Also disclosed are methods of treating or inhibiting neuronal degeneration, reducing or inhibiting one or more symptoms associated with neuronal degeneration and/or glaucoma in a subject. The methods include administering a therapeutically effective amount of a isolated mutant erythropoietin EPO polypeptide, an expression vector encoding such a mutant erythropoietin EPO polypeptide, a viral particle including an expression vector, or a composition, thereby treating or inhibiting neuronal degeneration in the subject.
FILED	Friday, June 23, 2017
APPL NO	15/632106
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/505 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/00 (20130101) C12N 7/00 (20130101) C12N 15/00 (20130101) C12N 15/10 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308708 — Antibodies that neutralize botulinum neurotoxins

US 10308708	Marks et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	James D. Marks (Kensington, California); Isin N. Geren (San Francisco, California)
ABSTRACT	This disclosure provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
FILED	Tuesday, August 16, 2016
APPL NO	15/238419
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/1282 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/52 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309177 — Cryogenic core collection

US 10309177	Sale et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Colorado State University Research Foundation (Fort Collins, Colorado); Richard L. Johnson (Portland, Oregon); Richard C. Rogers (Fort Collins, Colorado)
ASSIGNEE(S)	Colorado State University Research Foundation (Fort Collins, Colorado); Richard L. Johnson (Portland, Oregon); Richard C. Rogers (Fort Collins, Colorado)
INVENTOR(S)	Thomas C. Sale (Bellvue, Colorado); Richard L. Johnson (Portland, Oregon); Richard C. Rogers (Fort Collins, Colorado); Saeed Kiaalhosseini (Kitchener, Canada)
ABSTRACT	A system and method for collecting a core sample. The system includes an outer cylindrical tube, a drive head, a drive shoe, a cooling chamber housed inside the outer cylindrical tube, insulation, a core sample liner, an inlet tube, and outlet tube. The drive shoe further comprises a first, second, and third step, the first step configured to receive the insulation, the second step configured to receive the cooling chamber, the third step configured to receive the core sample liner, wherein the first step has a diameter larger than the second step and the second step has a diameter larger than the third step. The method includes drilling a hole in the ground with a drilling tool, enclosing a core sample by a core sample liner, freezing the core sample via a cooling liquid, retrieving the drilling tool at a surface of the ground, and removing the core sample encased in the core sample liner from the cooling chamber.
FILED	Thursday, June 15, 2017
APPL NO	15/624183
ART UNIT	3672 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 7/006 (20130101) E21B 25/06 (20130101) E21B 25/08 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10309254 — Nozzle segment for a gas turbine engine with ribs defining radially spaced internal cooling channels

US 10309254	Ugarte
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Johnnattan Tennessee Ugarte (Mason, Ohio)
ABSTRACT	A nozzle segment for a gas turbine engine may generally include an airfoil having an exterior surface defining a pressure side and a suction side extending between leading and trailing edges. The airfoil may define an open internal volume within its interior for receiving a cooling medium. The open internal volume may include a primary internal cavity and a plurality of internal cooling channels in flow communication with the primary internal cavity. The primary internal cavity may extend within the interior of the airfoil from a location adjacent to the leading edge to a forward end of each of the internal cooling channels. The internal cooling channels may extend within the interior of the airfoil from the primary internal cavity towards the trailing edge. In addition, the internal cooling channels may be spaced apart radially by a plurality of ribs extending within the interior of the airfoil.
FILED	Friday, February 26, 2016
APPL NO	15/054434
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/02 (20130101) F01D 5/186 (20130101) F01D 5/187 (20130101) F01D 5/188 (20130101) F01D 5/284 (20130101) F01D 9/02 (20130101) F01D 9/041 (20130101) F01D 25/12 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/35 (20130101) F05D 2260/22141 (20130101) F05D 2300/6033 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101) Y02T 50/676 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309255 — Blade outer air seal cooling passage

US 10309255	Romanov
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
ASSIGNEE(S)	United Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Dmitriy A. Romanov (Wells, Maine)
ABSTRACT	A gas turbine engine component includes a structure including a first wall and a second wall that provide a cooling passage. The cooling passage extends a length from a first end to a second end. A cluster of impingement inlet holes is provided in the second wall at the first end. An outlet is provided at the second end.
FILED	Wednesday, December 10, 2014
APPL NO	15/104092
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/08 (20130101) F01D 11/24 (20130101) F01D 25/12 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/11 (20130101) F05D 2240/127 (20130101) F05D 2260/201 (20130101) F05D 2260/2212 (20130101) F05D 2260/22141 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309304 — Electrical augmentation of a gas turbine engine

US 10309304	Bourne et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Sikorsky Aircraft Corporation (Stratford, Connecticut)
ASSIGNEE(S)	SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut)
INVENTOR(S)	Frederick L. Bourne (Litchfield, Connecticut); Mark Denton Bystry, Jr. (Stratford, Connecticut); Joseph Lawrence Simonetti (Southbury, Connecticut)
ABSTRACT	One aspect is an electrical augmentation system for a gas turbine engine. The electrical augmentation system includes an electric motor operably coupled to a shaft of the gas turbine engine, and an energy storage device operable to provide a temporary increased current source to the electric motor. The electrical augmentation system includes a control system having a torque demand anticipation circuit operable to determine an anticipated torque increase condition for the gas turbine engine. Based on the anticipated torque increase condition, the torque demand anticipation circuit commands a temporary torque increase by the electric motor using the energy storage device.
FILED	Tuesday, March 04, 2014
APPL NO	15/122825
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 15/10 (20130101) F01D 21/003 (20130101) F01D 21/14 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) F02C 6/14 (20130101) Original (OR) Class Starting of Combustion Engines; Starting Aids for Such Engines, Not Otherwise Provided for F02N 11/08 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/35 (20130101) F05D 2240/60 (20130101) F05D 2270/04 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309386 — Solid state pump using electro-rheological fluid

US 10309386	Liang et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Utah State University (Logan, Utah)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Utah State University (Logan, Utah)
INVENTOR(S)	Youzhi Liang (Cambridge, Massachusetts); Anette E. Hosoi (Cambridge, Massachusetts); Matthew F. Demers (Cambridge, Massachusetts); Karl D. Iagnemma (Belmont, Massachusetts); Jose R. Alvarado (Cambridge, Massachusetts); Regan A. Zane (Hyde Park, Utah); Michael Evzelman (Logan, Utah)
ABSTRACT	The systems and methods described herein are directed towards a solid state pumping system that utilizes an electric field applied across a channel formed within the solid state pump to move electro-rheological (ER) fluid from an inlet fluidly coupled to a first end of the channel to an outlet fluidly coupled to a second end of the channel. The solid state pumping system may include first, second and third plate with the second plate disposed between the first and third plate. The second plate may include a channel having first and second circuits coupled to opposing sides of the channel. In an embodiment, in response to a voltage applied thereto, the first and second circuits can provide an electric field voltage across the channel such that in response to the electric field voltage the ER fluid moves from the first end to the second end of the channel.
FILED	Tuesday, October 18, 2016
APPL NO	15/296694
ART UNIT	3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Positive-displacement Machines for Liquids; Pumps F04B 17/00 (20130101) F04B 19/006 (20130101) F04B 43/043 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10309398 — Passage arrangement for cooling, lubricating and reducing the size of rotary machines

US 10309398	Wagner
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Contracting Command (ACC) Redstone Arsenal (REDSTONE)
APPLICANT(S)	Jerald G. Wagner (Myakka City, Florida)
ASSIGNEE(S)	Mainstream Engineering Corporation (Rockledge, Florida)
INVENTOR(S)	Jerald G. Wagner (Myakka City, Florida)
ABSTRACT	A fluid-moving rotary device that has a drive mechanism whose rotational axis is aligned with a rotational axis of a driven component and another component that rotates about an axis offset from rotational axis of the driven component. The drive mechanism is located on a fluid inlet side of the components and is cooled by the fluid entering the device.
FILED	Friday, September 02, 2016
APPL NO	15/255657
ART UNIT	3748 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps F04C 2/16 (20130101) F04C 18/16 (20130101) Original (OR) Class F04C 2240/60 (20130101) F04C 2270/17 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 33/664 (20130101) F16C 33/6659 (20130101) F16C 37/007 (20130101) Pistons; Cylinders; Sealings F16J 15/4472 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309728 — Titanium-based thermal ground plane

US 10309728	MacDonald et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Space and Missile Defense Command (USASMDC)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Noel C. MacDonald (Santa Barbara, California); Carl D. Meinhart (Santa Barbara, California); Changsong Ding (Goleta, California); Payam Bozorgi (Santa Barbara, California); Gaurav Soni (Pasadena, California); Brian D. Piorek (Santa Barbara, California)
ABSTRACT	Titanium-based thermal ground planes are described. A thermal ground plane in accordance with the present invention comprises a titanium substrate comprising a plurality of pillars, wherein the plurality of Ti pillars can be optionally oxidized to form nanostructured titania coated pillars, and a vapor cavity, in communication with the plurality of titanium pillars, for transporting thermal energy from one region of the thermal ground plane to another region of the thermal ground plane.
FILED	Tuesday, July 22, 2014
APPL NO	14/338033
ART UNIT	3744 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/04 (20130101) Original (OR) Class F28D 15/046 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101) H01L 2924/00 (20130101) H01L 2924/0002 (20130101) H01L 2924/0002 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/4935 (20150115)
VIEW PATENT	@ USPTO: Full Text PDF

10309786 — Navigational and location determination system

US 10309786	Hamilton et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Surface Warfare Center (NSWC)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	John Hamilton (Solsberry, Indiana); Steven Gunderson (Crane, Indiana)
ABSTRACT	A navigation and location system is provided that can include an inertial measurement unit (IMU) comprising an in a strap down configuration and a global positioning system (GPS), and a control section that determines orientation of a range sensor aligned with one axis of the IMU with respect to the Earth based on a sequence of system orientation and location measurements from said IMU/GPS along a displaced path from a starting point (SP) to an activation point (AP). Remote geo-location of the object can be determined based on determined range and bearing to the object determined by rotating axis of at least one reference frame from the strap down IMU axis with gravity and aligning another axis with a line of longitude through the displacement path to determine true north then determining a azimuth or bearing angle between true north and the range sensor output axis oriented on the object.
FILED	Tuesday, February 21, 2017
APPL NO	15/438246
ART UNIT	3661 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/165 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/14 (20130101) G01S 19/19 (20130101) G01S 19/47 (20130101) G01S 19/53 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309835 — Body core temperature measurement

US 10309835	Larsen et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
INVENTOR(S)	Christopher Scott Larsen (Plymouth, Minnesota); Brian Keith Olmsted (Richfield, Minnesota)
ABSTRACT	An apparatus for measuring body core temperature includes a light guide with an internally reflective tube. The light guide is coupled to an earpiece, and has a lens or an aperture positioned at one of its ends. A sensor is positioned at the other end of the light guide, and a processor is coupled to the sensor. The sensor senses infrared radiation from an infrared source at the end of the light guide, and the processor determines a temperature of the infrared source at the end of the light guide via a transfer function that correlates a measure of the infrared radiation observed by the sensor and an effect of radiation of the light guide.
FILED	Thursday, January 21, 2016
APPL NO	15/003175
ART UNIT	2825 — Semiconductors/Memory
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/06 (20130101) G01J 5/0011 (20130101) G01J 5/0818 (20130101) G01J 5/0868 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10310027 — Systems and methods for detecting current using a kinetic inductance magnetic current imager

US 10310027	Nelson
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Robert H. Nelson (San Gabriel, California)
ABSTRACT	Under one aspect, a method for characterizing current of an operating device under test (DUT) includes injecting a signal into a superconducting sensor; determining a property of the superconducting sensor based on the injected signal; disposing the superconducting sensor in spaced relationship to the operating DUT; inducing a magnetic field in the superconducting sensor based on the spaced relationship, the current of the operating DUT, and the injected signal; determining a change in the property of the superconducting sensor resulting from the induced magnetic field; and estimating current of the operating DUT based on the change in the property of the superconducting sensor.
FILED	Friday, June 16, 2017
APPL NO	15/625652
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 15/20 (20130101) G01R 31/2601 (20130101) G01R 33/0354 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/04 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10310071 — Standoff geophysical anomaly detection system and method

US 10310071	Hull et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	David Mark Hull (Adelphi, Maryland); Gregory Alton Holifield (Eustis, Texas)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	David Mark Hull (Adelphi, Maryland); Gregory Alton Holifield (Eustis, Texas)
ABSTRACT	A system and method for measuring the complex resistivity of a ground section. One embodiment utilizes stand-off capacity-coupled resistivity (CCR) sensing to inject current into the ground at a frequency within the range of 1 Khz to 1 MHz. A sensor detects the voltage which is used to determine the complex resistively of the ground and, thus, ground content. The system and method permits surveys to be conducted at speeds of 10-20 mph or more. Alternatively, current is injected into the ground along a plasma channel that is enabled with a high energy laser. Alternatively, an alpha particle generator may be used to inject the current. Multiple frequencies may be used within the range of 1 KHz to 1 MHz to produce an impedivity spectroscopy to thereby determine and/or display a map of ground content.
FILED	Tuesday, September 16, 2008
APPL NO	11/999033
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/885 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10310491 — Radiating element and engineered magnetic material

US 10310491	Minko et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Glenn Minko (Staten Island, New York); Johnny Lee Daniel (Aberdeen, Maryland); Katherine Duncan (Newark, Delaware); James Breakall (Port Matilda, Pennsylvania); Mahmoud Khalil (Lincroft, New Jersey); Mohamed Khalil (Lincroft, New Jersey)
ABSTRACT	Various embodiments are described that relate to a radiating element and an engineered magnetic material. In a communication environment a radiating element can be used to communicate information, such as to send signals. Various factors, including electromagnetic factors, can influence the performance of the radiating element. In one example, if the radiating element becomes too close to a ground plane, then performance of the radiating element can suffer. To counter negative effects of being too close to the ground plane an engineered magnetic material can be employed that causes the radiating element to perform better when relatively close to the ground plane.
FILED	Wednesday, January 08, 2014
APPL NO	14/150165
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/41865 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 15/004 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10310517 — Autonomous cargo delivery system

US 10310517	Paduano et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Aurora Flight Sciences Corporation (Manassas, Virginia)
ASSIGNEE(S)	Aurora Flight Sciences Corporation (Manassas, Virginia)
INVENTOR(S)	James D. Paduano (Boston, Massachusetts); John B. Wissler (Waltham, Massachusetts); Michael D. Piedmonte (Stow, Massachusetts); David A. Mindell (Cambridge, Massachusetts)
ABSTRACT	An autonomous aerial system for delivering a payload to a waypoint. The autonomous aerial system may comprise an aerial vehicle to transport the payload to the waypoint and an onboard supervisory control system operatively coupled with the aerial vehicle. The aerial vehicle may be configured to navigate to the waypoint and to land at a designated touchdown zone within a landing zone at the waypoint. The onboard supervisory control system having a processor operatively coupled with a non-volatile memory device and a sensor package. The processor may be configured to generate flight control signal data based at least in part on data received via the sensor package, the sensor package configured to (1) dynamically sense and avoid obstacles along a flight route to the waypoint, and (2) perceive physical characteristics of the landing zone. The processor may be configured to autonomously navigate the aerial vehicle to the waypoint and to determine whether to touchdown at the designated touchdown zone based at least in part on physical characteristics of the designated touchdown zone perceived via said sensor package.
FILED	Wednesday, April 04, 2018
APPL NO	15/945351
ART UNIT	3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Systems for Controlling or Regulating Non-electric Variables G05D 1/042 (20130101) G05D 1/102 (20130101) Original (OR) Class G05D 1/0202 (20130101) G05D 1/0676 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/00 (20130101) G06Q 10/08 (20130101) G06Q 50/28 (20130101) G06Q 50/265 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10310991 — Timely address space randomization

US 10310991	Okhravi et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Hamed Okhravi (Billerica, Massachusetts); Thomas R. Hobson (Belmont, Massachusetts); David O. Bigelow (Maynard, Massachusetts); Robert Rudd (Cambridge, Massachusetts); William W. Streilein (Sudbury, Massachusetts)
ABSTRACT	A method for timely address space randomize includes loading a code region from a program binary to a first location within the address space, detecting, during execution of the program, an output-input call pair from the program and, in response to detecting the output-input call pair from the program: selecting a second location within the address space to move the code region to, determining memory locations of one or more references to the code region, updating the values of the references in memory based on the second location and using annotation information within the program binary, and moving the code region to the second location within the address space.
FILED	Thursday, August 11, 2016
APPL NO	15/234028
ART UNIT	2192 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 12/023 (20130101) G06F 12/1408 (20130101) Original (OR) Class G06F 16/245 (20190101) G06F 21/52 (20130101) G06F 21/54 (20130101) G06F 21/125 (20130101) G06F 21/577 (20130101) G06F 2212/1052 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10311050 — Crowdsourced discovery of paths in a knowledge graph

US 10311050	Beller et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Charles E. Beller (Baltimore, Maryland); Donna K. Byron (Petersham, Massachusetts); Benjamin L. Johnson (Baltimore, Maryland)
ABSTRACT	The disclosed embodiments include a system, computer program product, and computer-implemented method configured to modify a knowledge graph. The disclosed embodiments seek to improve the process of expanding a knowledge graph by identifying information that is useful and relevant to the needs of the users based on questions being asked by users. In one embodiment, the information is collected using a gaming platform. The disclosed embodiments augment the knowledge graph, by adding new entities and/or relationships, based on the gathered information.
FILED	Monday, January 23, 2017
APPL NO	15/413103
ART UNIT	2163 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/243 (20190101) Original (OR) Class G06F 16/9024 (20190101)
VIEW PATENT	@ USPTO: Full Text PDF

10311243 — Method and apparatus for secure communication

US 10311243	Calmon et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); National University of Ireland Maynooth (Maynooth, Ireland)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); National University of Ireland Maynooth (Maynooth, Ireland)
INVENTOR(S)	Flavio du Pin Calmon (White Plains, New York); Muriel Medard (Belmont, Massachusetts); Linda M. Zeger (Lexington, Massachusetts); Mark M. Christiansen (Dublin, Ireland); Kenneth R. Duffy (Dublin, Ireland)
ABSTRACT	Secrecy scheme systems and associated methods using list source codes for enabling secure communications in communications networks are provided herein. Additionally, improved information-theoretic metrics for characterizing and optimizing said secrecy scheme systems and associated methods are provided herein. One method of secure communication comprises receiving a data file at a first location, encoding the data file using a list source code to generate an encoded file, encrypting a select portion of the data file using a key to generate an encrypted file, and transmitting the encoded file and the encrypted file to an end user at a destination location, wherein the encoded file cannot be decoded at the destination location until the encrypted file has been received and decrypted by the end user, wherein the end user possesses the key.
FILED	Thursday, March 13, 2014
APPL NO	14/208683
ART UNIT	2491 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/6209 (20130101) Original (OR) Class Coding; Decoding; Code Conversion in General H03M 13/1102 (20130101) H03M 13/1515 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/065 (20130101) H04L 63/0435 (20130101) H04L 2209/30 (20130101) H04L 2209/34 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10311285 — Polarization imaging for facial recognition enhancement system and method

US 10311285	Pezzaniti et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Polaris Sensor Technologies, Inc. (Huntsville, Alabama)
ASSIGNEE(S)	POLARIS SENSOR TECHNOLOGIES, INC. (Huntsville, Alabama)
INVENTOR(S)	J. Larry Pezzaniti (Huntsville, Alabama); David B. Chenault (Huntsville, Alabama)
ABSTRACT	A method for enhancing an image for facial recognition comprises capturing an image of the face with a polarizer and correcting the polarized image for non-uniformity. Stokes Parameters S₀, S₁, S₂are obtained by weighted subtraction of the polarized image to form Stokes images. DoLP is computed from the Stokes images, and facial recognition algorithms are applied to the DoLP image. A system for enhancing images for facial recognition comprises a polarimeter configured to record polarized image data of a subject's face, a signal processing unit and logic configured to receive and store in memory the image data from the polarimeter, calculate Stokes parameters from the image data, and compute a DoLP image from the Stokes parameters.
FILED	Thursday, January 22, 2015
APPL NO	14/602823
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 27/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/209 (20130101) G06K 9/00255 (20130101) G06K 9/00275 (20130101) G06K 9/00288 (20130101) Original (OR) Class G06K 9/4661 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10311341 — System and method for online deep learning in an ultra-low power consumption state

US 10311341	Cao et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Yongqiang Cao (Newton, Massachusetts); Praveen K. Pilly (West Hills, California); Narayan Srinivasa (Hillsboro, Oregon)
ABSTRACT	Described is a system and method for ultra-low power consumption state deep online learning. The system operates by filtering an input image to generate one or more feature maps. The one or more feature maps are divided into non-overlapping small regions with feature values in each small region pooled to generate decreased size feature maps. The decreased size feature maps are divided into overlapping patches which are joined together to form a collection of cell maps having connections to the decreased sized feature maps. The collection of cell maps are then divided into non-overlapping small regions, with feature values in each small region pooled to generate a decreased sized collection of cell maps. The decreased sized collection of cell maps are then mapped to a single cell, which results in a class label being generated as related to the input image based on the single cell.
FILED	Monday, August 29, 2016
APPL NO	15/249849
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/66 (20130101) Original (OR) Class G06K 9/4628 (20130101) G06K 9/6259 (20130101) G06K 9/6265 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0409 (20130101) Image Data Processing or Generation, in General G06T 5/20 (20130101) G06T 7/0085 (20130101) G06T 15/20 (20130101) G06T 2207/20021 (20130101) G06T 2207/20024 (20130101) G06T 2207/20081 (20130101) Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/20 (20130101) G09G 5/001 (20130101) Pulse Technique H03K 3/0315 (20130101) H03K 4/50 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/001 (20130101) H04L 9/12 (20130101) Pictorial Communication, e.g Television H04N 19/156 (20141101)
VIEW PATENT	@ USPTO: Full Text PDF

10311356 — Unsupervised behavior learning system and method for predicting performance anomalies in distributed computing infrastructures

US 10311356	Gu et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF)
APPLICANT(S)	North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)	North Carolina State University (Raleigh, North Carolina)
INVENTOR(S)	Xiaohui Gu (Raleigh, North Carolina); Daniel Dean (Raleigh, North Carolina)
ABSTRACT	An unsupervised behavior learning system and method for predicting anomalies in a distributed computing infrastructure. The distributed computing infrastructure includes a plurality of computer machines. The system includes a first computer machine and a second computer machine. The second computer machine is configured to generate a model of normal and anomalous behavior of the first computer machine, where the model is based on unlabeled training data. The second computer machine is also configured to acquire real-time data of system level metrics of the first machine; determine whether the real-time data is normal or anomalous based on a comparison of the real-time data to the model; and predict a future failure of the first computer machine based on multiple consecutive comparisons of the real-time data to the model. Upon predicting a future failure of the first computer machine, generate a ranked set of system-level metrics which are contributors to the predicted failure of the first computer machine, and generate an alarm that includes the ranked set of system-level metrics. The model of normal and anomalous behavior may include a self-organizing map.
FILED	Monday, September 08, 2014
APPL NO	14/480270
ART UNIT	2124 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10311357 — Thermodynamic-RAM technology stack

US 10311357	Nugent et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	KnowmTech, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	KnowmTech, LLC (Santa Fe, New Mexico)
INVENTOR(S)	Alex Nugent (Santa Fe, New Mexico); Timothy Molter (Oberstdorf, Germany)
ABSTRACT	A thermodynamic RAM technology stack, two or more memristors or pairs of memristors comprising AHaH (Anti-Hebbian and Hebbian) computing components, and one or more AHaH nodes composed of such memristor pairs that form at least a portion of the thermodynamic RAM technology stack. The levels of the thermodynamic-RAM technology stack include the memristor, a Knowm synapse, an AHaH node, a kT-RAM, kT-RAM instruction set, a sparse spike encoding, a kT-RAM emulator, and a SENSE Server.
FILED	Wednesday, May 27, 2015
APPL NO	14/722626
ART UNIT	2827 — Semiconductors/Memory
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Original (OR) Class G06N 3/049 (20130101) G06N 3/063 (20130101) G06N 20/00 (20190101) Static Stores G11C 11/54 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10311358 — Systems and methods for multi-objective evolutionary algorithms with category discovery

US 10311358	Thompson
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	THE AEROSPACE CORPORATION (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Timothy Guy Thompson (Purcellville, Virginia)
ABSTRACT	Systems and methods are provided to engage in multi-tiered optimization where there may be a first multi-objective optimization and a second constraint optimization. The multi-objective optimization may be used to drive to one or more goals of the optimization problem. The constraint optimization or minimization may be used to drive towards a reduced and/or no constraint situation where the solution to the overall problem is feasible or near-feasible.
FILED	Friday, July 10, 2015
APPL NO	14/796299
ART UNIT	2123 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/126 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10311752 — Compressed edge map representation for image aided navigation

US 10311752	Elgersma et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	Honeywell International Inc. (Morris Plains, New Jersey)
INVENTOR(S)	Michael Ray Elgersma (Plymouth, Minnesota); Benjamin Mohr (St. Louis Park, Minnesota)
ABSTRACT	A method of generating a map for image aided navigation comprises detecting one or more edges in one or more terrain images, and obtaining a compressed edge representation of the one or more edges. The compressed edge representation is obtained by a method comprising fitting a geometric form or other mathematical model to the one or more edges, calculating one or more coefficients based on the fitted geometric form or other mathematical model, and storing the one or more coefficients in a database for use in generating the map for image aided navigation.
FILED	Friday, February 03, 2017
APPL NO	15/424188
ART UNIT	2669 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/00 (20130101) Electric Digital Data Processing G06F 16/29 (20190101) G06F 16/50 (20190101) G06F 17/30241 (20130101) G06F 17/30244 (20130101) Image Data Processing or Generation, in General G06T 7/13 (20170101) G06T 9/20 (20130101) G06T 17/00 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/04 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10311992 — Transparent conducting films including complex oxides

US 10311992	Engel-Herbert et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania)
INVENTOR(S)	Roman Engel-Herbert (University Park, Pennsylvania); Lei Zhang (University Park, Pennsylvania)
ABSTRACT	Transparent conducting films including an alkaline earth, transition metal oxide and their optimization of electrical conductivity and optical transparency by aliovalent substitution, which are useful as electrodes for semiconductors and other electronic devices are disclosed. Such materials include thin films of an aliovalent substituted transition metal oxides of Formula (I): A_1-xA′_xB_1-yB′_yO_3-d(I) or a transition metal oxide of Formula (II): (ABO_3-d)m(A′B′O_3-d′)n.
FILED	Friday, July 31, 2015
APPL NO	14/815546
ART UNIT	1784 — Miscellaneous Articles, Stock Material
CURRENT CPC	Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 31/02 (20130101) C01G 31/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/40 (20130101) C01P 2006/60 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/08 (20130101) C23C 14/22 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/08 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10312082 — Metal based nanowire tunnel junctions

US 10312082	Mi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Zetian Mi (Verdun, Canada); Sharif Sadaf (Hamilton, Canada); Yong-Ho Ra (Montreal, Canada); Thomas Szkopek (Outremont, Canada)
ABSTRACT	Semiconductor light emitting diodes (LEDs) formed as (Al)GaN-based nanowire structures have a first semiconductor layer, a second semiconductor layer, and a thin metallic layer fabricated therebetween. The structures, operating in the deep ultraviolet (UV) spectral range, exhibit high photoluminescence efficiency at room temperature. The structures may be formed of an epitaxial metal tunnel junction operating as a reflector that enhances carrier transport to and from the semiconductor alloy layers, capable of producing external quantum efficiencies at least one order of magnitude higher than convention devices.
FILED	Tuesday, May 09, 2017
APPL NO	15/590768
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02603 (20130101) Original (OR) Class H01L 27/153 (20130101) H01L 31/109 (20130101) H01L 33/002 (20130101) H01L 33/06 (20130101) H01L 33/32 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/762 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312091 — Secure permanent integrated circuit personalization

US 10312091	Smayling et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Multibeam Corporation (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S)	Michael C. Smayling (Fremont, California); David K. Lam (Saratoga, California)
ABSTRACT	Methods, systems and devices for using charged particle beams (CPBs) to write different die-specific, non-volatile, electronically readable data to different dies on a substrate. CPBs can fully write die-specific data within the chip interconnect structure during the device fabrication process, at high resolution and within a small area, allowing one or multiple usefully-sized values to be securely written to service device functions. CPBs can write die-specific data in areas readable or unreadable through a (or any) communications bus. Die-specific data can be used for, e.g.: encryption keys; communications addresses; manufacturing information (including die identification numbers); random number generator improvements; or single, nested, or compartmentalized security codes. Die-specific data and locations for writing die-specific data can be kept in encrypted form when not being written to the substrate to conditionally or permanently prevent any knowledge of said data and locations.
FILED	Friday, September 09, 2016
APPL NO	15/260987
ART UNIT	2851 — Printing/Measuring and Testing
CURRENT CPC	Electric Digital Data Processing G06F 21/602 (20130101) G06F 2221/2143 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/263 (20130101) Original (OR) Class H01L 21/3065 (20130101) H01L 23/544 (20130101) H01L 23/573 (20130101) H01L 2223/54413 (20130101) H01L 2223/54433 (20130101) H01L 2223/54473 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312175 — Diamond air bridge for thermal management of high power devices

US 10312175	Hobart et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Karl D. Hobart (Alexandria, Virginia); Andrew D. Koehler (Alexandria, Virginia); Francis J. Kub (Arnold, Maryland); Travis J. Anderson (Alexandria, Virginia); Tatyana I. Feygelson (Springfield, Virginia); Marko J. Tadjer (Springfield, Virginia); Lunet E. Luna (Wheaton, Maryland)
ABSTRACT	A device structure and method for improving thermal management in highly scaled, high power electronic and optoelectronic devices such as GaN FET and AlGaN/GaN HEMT devices by implementing diamond air bridges into such devices to remove waste heat. The diamond air bridge can be formed from a polycrystalline diamond material layer which can be grown on the surface of a dielectric material layer, on the surface of a III-nitride material, or on the surface of a diamond polycrystalline nucleation layer, and may be optimized to have a high thermal conductivity at the growth interface with the underlying material.
FILED	Thursday, April 05, 2018
APPL NO	15/945803
ART UNIT	2829 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/4803 (20130101) H01L 23/3732 (20130101) Original (OR) Class H01L 29/205 (20130101) H01L 29/452 (20130101) H01L 29/475 (20130101) H01L 29/2003 (20130101) H01L 29/7787 (20130101) H01L 29/66462 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312358 — High electron mobility transistors with improved heat dissipation

US 10312358	Ren et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA)
APPLICANT(S)	UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida)
ASSIGNEE(S)	UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida)
INVENTOR(S)	Fan Ren (Gainesville, Florida); Stephen John Pearton (Gainesville, Florida); Mark E. Law (Gainesville, Florida); Ya-Hsi Hwang (Gainesville, Florida)
ABSTRACT	III-nitride based high electron mobility transistors (HEMTs), such as AlGaN/GaN HEMTs on Silicon substrates, with improved heat dissipation are described herein. A semiconductor device having improved heat dissipation may include a substrate having a top surface and a bottom surface, a nucleation layer on the top surface of the substrate, a transition layer on the nucleation layer, a buffer layer on the transition layer, a barrier layer on the buffer layer, and a metal layer filling a via hole that extends from the bottom surface of the substrate to a bottom surface of the transition layer.
FILED	Friday, October 02, 2015
APPL NO	15/516536
ART UNIT	2826 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/36 (20130101) H01L 29/205 (20130101) H01L 29/0657 (20130101) H01L 29/778 (20130101) Original (OR) Class H01L 29/2003 (20130101) H01L 29/4175 (20130101) H01L 29/7786 (20130101) H01L 29/41758 (20130101) H01L 29/66462 (20130101) H01L 2924/00 (20130101) H01L 2924/0002 (20130101) H01L 2924/0002 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312388 — Method and optoelectronic structure providing polysilicon photonic devices with different optical properties in different regions

US 10312388	Meade et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Micron Technology, Inc. (Boise, Idaho); Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Micron Technology, Inc. (Boise, Idaho); Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Roy Meade (Boise, Idaho); Karan Mehta (Cambridge, Massachusetts); Efraim Megged (Mata, Israel); Jason Orcutt (Katonah, New York); Milos Popovic (Boulder, Colorado); Rajeev Ram (Arlington, Massachusetts); Jeffrey Shainline (Boulder, Colorado); Zvi Sternberg (Metar, Israel); Vladimir Stojanovic (Berkeley, California); Ofer Tehar-Zahav (Hadera, Israel)
ABSTRACT	Method and structural embodiments are described which provide an integrated structure using polysilicon material having different optical properties in different regions of the structure.
FILED	Wednesday, August 16, 2017
APPL NO	15/679028
ART UNIT	2898 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1443 (20130101) H01L 31/182 (20130101) H01L 31/1804 (20130101) H01L 31/02327 (20130101) Original (OR) Class H01L 31/03682 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/546 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/521 (20151101)
VIEW PATENT	@ USPTO: Full Text PDF

10312389 — Optical detector device with patterned graphene layer and related methods

US 10312389	Chanda et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
ASSIGNEE(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
INVENTOR(S)	Debashis Chanda (Oviedo, Florida); Alireza Safaei (Orlando, Florida); Michael Leuenberger (Orlando, Florida)
ABSTRACT	An optical detector device may include a substrate, a reflector layer carried by the substrate, and a first dielectric layer over the reflector layer. The optical detector device may include a graphene layer over the first dielectric layer and having a perforated pattern.
FILED	Friday, October 13, 2017
APPL NO	15/782948
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/553 (20130101) G01N 21/554 (20130101) G01N 2021/7773 (20130101) Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) G02B 5/12 (20130101) G02B 5/0866 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/307 (20130101) H01L 31/09 (20130101) H01L 31/101 (20130101) H01L 31/0232 (20130101) H01L 31/0328 (20130101) H01L 31/035209 (20130101) Original (OR) Class H01L 51/42 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312397 — Avalanche photodiode with low breakdown voltage

US 10312397	Kang et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)	Intel Corporation (Santa Clara, California)
INVENTOR(S)	Yimin Kang (San Jose, California); Han-Din Liu (San Jose, California)
ABSTRACT	An Si/Ge SACM avalanche photodiodes (APD) having low breakdown voltage characteristics includes an absorption region and a multiplication region having various layers of particular thicknesses and doping concentrations. An optical waveguide can guide infrared and/or optical signals or energy into the absorption region. The resulting photo-generated carriers are swept into the i-Si layer and/or multiplication region for avalanche multiplication. The APD has a breakdown bias voltage of well less than 12 V and an operating bandwidth of greater than 10 GHz, and is therefore suitable for use in consumer electronic devices, high speed communication networks, and the like.
FILED	Friday, February 24, 2017
APPL NO	15/442512
ART UNIT	2891 — Semiconductors/Memory
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/42 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1075 (20130101) Original (OR) Class H01L 31/02027 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312426 — Giant cross-plane seebeck effect in oxide metal semiconductor superlattices for spin-magnetic thermoelectric devices

US 10312426	Jha et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Pankaj Jha (Hillsboro, Oregon); Timothy D. Sands (West Lafayette, Indiana)
ABSTRACT	Lanthanum strontium manganate (La_0.67Sr_0.33MnO₃, i.e., LSMO)/lanthanum manganate (LaMnO₃, i.e., LMO) perovskite oxide metal/semiconductor superlattices were investigated for potential p-type thermoelectric applications. Growth optimizations were performed using pulsed laser deposition to achieve epitaxial superlattices of LSMO (metal)/LMO (p-type semiconductor) on strontium titanate (STO) substrates. The cross-plane Seebeck coefficient of the thermoelectric superlattice measured between the substrate and the capping layer has a value of at least 1600 μV/K measured at about 300K.
FILED	Friday, March 15, 2013
APPL NO	13/840378
ART UNIT	1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/22 (20130101) Original (OR) Class H01L 35/26 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312590 — Small UWB antennas and method of designing the same

US 10312590	Jones, III
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	SPAWAR Systems Center Pacific (San Diego, California)
ASSIGNEE(S)	The United States of America as represented by Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Thomas O Jones, III (San Diego, California)
ABSTRACT	A method is provided for designing an ultra-wide band conical antenna having a bulb shape with a conical feed point having a predetermined input feed resistance. The method includes: choosing a charge distribution cone angle, ψ, for the predetermined input feed resistance; choosing the length of the charge distribution, κ; determining a desired resistance, capacitance and a Q-factor via a quasistatic antenna design algorithm based on ψ and κ; and selecting an ultra-wide band conical antenna design having a bulb shape with a conical feed point, from among the set of ultra-wide band conical antenna designs having a bulb shape with a conical feed point, that produces the desired resistance, capacitance and Q-factor.
FILED	Monday, July 31, 2017
APPL NO	15/664377
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/36 (20130101) H01Q 5/25 (20150115) Original (OR) Class H01Q 9/32 (20130101) H01Q 11/08 (20130101) H01Q 13/02 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312595 — Contrawound helical antenna apparatus and method

US 10312595	Jablon et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Sea Systems Command (NAVSEA)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Allan R. Jablon (Ellicott City, Maryland); Gerald F. Ricciardi (Mt. Airy, Maryland)
ABSTRACT	Example apparatuses and methods relating to antennas are provided. An example apparatus in the form of an antenna assembly includes a first conductor formed into a first helical structure wound around a central axis and a second conductor formed into a second helical structure wound around the central axis. The first helical structure may have a first coil sense and the second helical structure may have second coil sense that is opposite the first coil sense. The first conductor may have a first conductor proximal end and a first conductor distal end and the second conductor may have a second conductor proximal end and a second conductor distal end. The first conductor distal end may be adjacent the second conductor proximal end. The antenna assembly may further include first, second, and third ground planes with one disposed at each end of the conductors and one disposed between the conductors.
FILED	Friday, November 18, 2016
APPL NO	15/355557
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/48 (20130101) H01Q 3/247 (20130101) H01Q 11/083 (20130101) Original (OR) Class H01Q 21/245 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312657 — Coherent combining pulse bursts in time domain

US 10312657	Galvanauskas
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Almantas Galvanauskas (Ann Arbor, Michigan)
ABSTRACT	A beam combining and pulse stacking technique is provided that enhances laser pulse energy by coherent stacking pulse bursts (i.e. non-periodic pulsed signals) in time domain. This energy enhancement is achieved by using various configurations of Fabry-Perot, Gires-Tournois and other types of resonant cavities, so that a multiple-pulse burst incident at either a single input or multiple inputs of the system produces an output with a solitary pulse, which contains the summed energy of the incident multiple pulses from all beams. This disclosure provides a substantial improvement over conventional coherent-combining methods in that it achieves very high pulse energies using a relatively small number of combined laser systems, thus providing with orders of magnitude reduction in system size, complexity, and cost compared to current combining approaches.
FILED	Wednesday, October 04, 2017
APPL NO	15/724723
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 27/1006 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/005 (20130101) H01S 3/23 (20130101) H01S 3/1062 (20130101) Original (OR) Class H01S 3/1307 (20130101) H01S 3/2308 (20130101) H01S 3/2383 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312658 — Brillouin gain spectral position control of claddings for tuning acousto-optic waveguides

US 10312658	Puckett
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	Honeywell International Inc. (Morris Plains, New Jersey)
INVENTOR(S)	Matthew Wade Puckett (Scottsdale, Arizona)
ABSTRACT	A method of fabricating an acousto-optic waveguide that includes a waveguide cladding surrounding an optical core is disclosed. The method comprises providing a wafer substrate; depositing an initial amount of a first material over an upper surface of the wafer substrate to form a partial cladding layer; depositing a second material over the partial cladding layer to form an optical layer; removing portions of the second material of the optical layer to expose portions of the partial cladding layer and form an optical core comprising the remaining second material; and depositing an additional amount of the first material over the optical core and the exposed portions of the partial cladding layer to form a full cladding layer that surrounds the optical core. A relative concentration of components of the first material is adjusted to provide Brillouin gain spectral position control of the waveguide cladding to tune the acousto-optic waveguide.
FILED	Thursday, June 22, 2017
APPL NO	15/630261
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/661 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/125 (20130101) G02F 1/365 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/30 (20130101) H01S 3/083 (20130101) H01S 3/302 (20130101) H01S 3/0637 (20130101) H01S 3/1068 (20130101) Original (OR) Class H01S 3/094042 (20130101) H01S 3/094053 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312710 — Energy recovery pulse forming network

US 10312710	Martino
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Christopher Adrian Martino (Arnold, Maryland)
ABSTRACT	An energy recovery pulse forming network and method that recovers at least a portion of the energy in a railgun by transferring energy dissipated from the railgun inductance back to an initial source of the energy, such as an input capacitor, for use by the network. This reduces the amount of energy required from an external power source to charge the input capacitor during subsequent railgun firings.
FILED	Monday, March 20, 2017
APPL NO	15/463135
ART UNIT	2836 — Electrical Circuits and Systems
CURRENT CPC	Weapons for Projecting Missiles Without Use of Explosive or Combustible Propellant Charge; Weapons Not Otherwise Provided for F41B 6/006 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/007 (20130101) Original (OR) Class H02J 7/0068 (20130101) H02J 7/345 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312797 — Zero power startup circuit for vibrational energy harvesting

US 10312797	Phipps et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	SPAWAR Systems Center Pacific (San Diego, California)
ASSIGNEE(S)	The United States of America as represented by Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Alex G. Phipps (San Diego, California); Eric G. Bozeman (La Mesa, California)
ABSTRACT	An energy harvesting system includes a transducer, a capacitor, a power converter, a power converter control line, a control switch and a control switch control line. The transducer harvests energy and outputs electrical current based on the harvested energy. The capacitor stores a rectified voltage based on the electrical current. The control switch can be open or closed. The control switch control line is arranged to provide a control voltage based on the rectified voltage to the control switch. When the control voltage is equal to or greater than a threshold voltage the control switch is closed such that the power converter control line electrically connects the power converter to a battery in order to provide harvested energy to the battery.
FILED	Monday, August 29, 2016
APPL NO	15/250299
ART UNIT	2836 — Electrical Circuits and Systems
CURRENT CPC	Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0052 (20130101) H02J 2007/0059 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/36 (20130101) Original (OR) Class H02M 3/158 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312820 — System and method for power conversion

US 10312820	Fogel
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	Accion Systems, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Accion Systems, Inc. (Boston, Massachusetts)
INVENTOR(S)	Paul E. Fogel (Boston, Massachusetts)
ABSTRACT	A polarity-selectable high voltage direct current power supply including a first drive assembly that transforms a first low voltage DC input into a first medium voltage alternating current output; a first HV output assembly that transforms the first LV AC output into a first HV DC output, wherein the first HV output assembly defines a first input stage; a polarity selector coupled between the second output junction of the first drive assembly and the first and second input stages of the first HV output assembly, the polarity selector operable between a first configuration and a second configuration; wherein in the first configuration the first HV DC output has a positive polarity; and wherein in the second configuration the first HV DC output has a negative polarity.
FILED	Wednesday, October 10, 2018
APPL NO	16/156834
ART UNIT	2838 — Electrical Circuits and Systems
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 27/022 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) H02M 3/3376 (20130101) H02M 3/33561 (20130101) H02M 3/33569 (20130101) Original (OR) Class H02M 7/103 (20130101) H02M 2001/008 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312963 — Systems and methods for use in communicating data

US 10312963	Sayano et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Masahiro Sayano (Torrance, California); Michael S. Cheung (Fullerton, California); Oliver D. Ambrosia (Los Angeles, California); David M. Schwartz (Northridge, California)
ABSTRACT	A system comprises a transmitter configured to receive at least one message that corresponds to at least one set of data received from at least one user. The transmitter includes a modulating device that is configured to generate at least one signal that corresponds to the received message, wherein the signal includes at least one sequence of a plurality of hopping patterns. A receiver is coupled to the transmitter, wherein the receiver is configured to receive the signal. The receiver includes a demodulating device that is configured to identify the sequence of the hopping patterns and to determine at least one variable that corresponds to the sequence of the hopping patterns. The demodulating device is further configured to generate at least one output that is based on the determined variable, wherein the output is displayed such that at least one other user is enabled to view the output.
FILED	Wednesday, August 24, 2016
APPL NO	15/246295
ART UNIT	2631 — Digital Communications
CURRENT CPC	Transmission H04B 1/715 (20130101) H04B 1/7156 (20130101) Original (OR) Class H04B 7/18523 (20130101) Wireless Communication Networks H04W 4/12 (20130101) H04W 84/06 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312984 — Distributed airborne beamforming system

US 10312984	Yazdani et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Navid Yazdani (Sudbury, Massachusetts); David W. Browne (Somerville, Massachusetts); Keith William Forsythe (Lexington, Massachusetts)
ABSTRACT	A distributed beamforming communication system including independent aerial nodes forming an antenna array is described. Described herein is a distributed beamforming array which utilizes independent aerial relay nodes or platforms (i.e. no strict control of relay node position, no communication between the relay nodes, and no coordinated transmission among the relay nodes) to form a distributed beamforming antenna.
FILED	Thursday, April 16, 2015
APPL NO	15/126109
ART UNIT	2466 — Multiplex and VoIP
CURRENT CPC	Transmission H04B 7/0617 (20130101) Original (OR) Class H04B 7/18502 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10313164 — Techniques for implementing a portable spectrum analyzer

US 10313164	Mody et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Apurva N. Mody (Nashua, New Hampshire); Jack Chuang (Nashua, New Hampshire); Ronald Lawrence (Nashua, New Hampshire); Chad M. Spooner (Carmel, California)
ABSTRACT	Techniques are provided for implementing a portable spectrum analyzer. An example system, according to an embodiment, includes a signal analyzer including an RF receiver to receive RF signals from an antenna, an analog-to-digital converter to generate a sampled signal based on the received RF signals, and a signal analysis co-processor to perform cognitive scanning analysis of the sampled signal. The cognitive scanning analysis includes detection, identification, and characterization of digital/analog signal(s) embedded in the sampled signal. The system may further include a communications interface circuit to provide communication between the signal analyzer and an associated mobile host platform (e.g., smartphone). The communication includes transmitting results of the cognitive scanning analysis to the mobile host and receiving parameters from the mobile host to control the operation of the cognitive scanning analysis. The signal analyzer and mobile host are coupled through a shared enclosure such as a hinged case, sleeve, or wallet.
FILED	Friday, May 05, 2017
APPL NO	15/588256
ART UNIT	2637 — Optical Communications
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 23/16 (20130101) Transmission H04B 17/391 (20150115) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/0006 (20130101) Original (OR) Class Telephonic Communication H04M 1/185 (20130101) H04M 1/72522 (20130101) H04M 1/72527 (20130101) Wireless Communication Networks H04W 52/50 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10314112 — Self-regulating packed-powder resistive heater

US 10314112	Swanson
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	SPAWAR Systems Center Pacific (San Diego, California)
ASSIGNEE(S)	The United States of America as represented by Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Paul David Swanson (Santee, California)
ABSTRACT	A heater comprising: an outer tube having a first thermal expansion coefficient; an inner tube having a second thermal expansion coefficient that is less than the first thermal expansion coefficient, wherein the inner tube is disposed concentrically with the outer tube such that there is a space between the inner and outer tubes; a conductive powder disposed within the space between the inner and outer tubes; and two electrodes in electrical contact with the conductive powder such that when a potential is introduced between the electrodes, the conductive powder functions as a resistive heater whose resistance changes with temperature based on different degrees of thermal expansion of the inner and outer tubes.
FILED	Friday, November 04, 2016
APPL NO	15/343961
ART UNIT	3761 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Electric Heating; Electric Lighting Not Otherwise Provided for H05B 3/0004 (20130101) H05B 3/0023 (20130101) H05B 3/60 (20130101) H05B 3/145 (20130101) Original (OR) Class H05B 2203/009 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10314151 — Charged particle accelerators, radiation sources, systems, and methods

US 10314151	Whittum et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	Varex Imaging Corporation (Salt Lake City, Utah)
ASSIGNEE(S)	Varex Imaging Corporation (Salt Lake City, Utah)
INVENTOR(S)	David Whittum (Sunnyvale, California); James E. Clayton (San Jose, California); George Merdinian (Los Altos, California)
ABSTRACT	Man-portable radiation generation sources and systems that may be carried by hand to a site of interest by one or two people, are disclosed. Methods of use of such sources and systems are also disclosed. Battery operated radiation generation sources, air cooled radiation generation sources, and charged particle accelerators, are also disclosed. A radiation generation source, a radiation scanning system, and a target assembly comprising target material having a thickness of less than 0.20 mm are also disclosed.
FILED	Tuesday, May 12, 2015
APPL NO	14/710202
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/0016 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 35/02 (20130101) H01J 2235/08 (20130101) X-ray Technique H05G 1/04 (20130101) Original (OR) Class H05G 1/10 (20130101) H05G 1/025 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 9/04 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Energy (DOE)

10307527 — Protein-based nanobubble x-ray imaging method and agent

US 10307527	Rose-Petruck et al.
FUNDED BY	Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Brown University (Providence, Rhode Island); MONTANA STATE UNIVERSITY (Bozeman, Montana)
ASSIGNEE(S)	Brown University (Providence, Rhode Island); Montana State University (Bozeman, Montana)
INVENTOR(S)	Christoph Rose-Petruck (Barrington, Rhode Island); Trevor Douglas (Bloomington, Indiana); Danielle Rand (Walpole, Massachusetts); Masaki Uchida (Bloomington, Indiana)
ABSTRACT	Systems, compositions, methods and kits employ protein shells, such as ferritin or viral capsid shells, herein called nanobubbles, to enhance X-ray images of cells or body tissue under certain x-ray imaging methods. The nanobubbles have sub-micron size such as about 10 nm, about 40, 60, or 100 nm and may be functionalized for effective delivery to or uptake by a target tissue, in vivo or a cell culture. The nanobubbles are hollow, having a central core which may be empty or contain a fluid, such that the shells effectively form long-lived bubbles in the imaged environment, and are of low electron density and have different scattering properties than the surrounding tissue. X-ray imaging by spatial frequency heterodyne imaging enhances visualization or detection of tissue regions bearing the shells. The protein shells may be further treated to assure biocompatibility and/or to resist undesired interactions with non-targeted tissue, such as scavenging by the liver, or attack by the immune system. For example the nanobubbles may be filled with a hydrophobic gas such as perfluoropropane (octafluoropropane) to maintain their shape and resist hydrophilic interactions and delay the degradation of the protein shells. The nanobubbles may also be coated or treated by a surface-functionalization processes to effectively target specific tissues or tumor types, allow parenteral delivery, and/or deliver drugs or other agents to the imaged sites—so that when visualized by X-ray scatter imaging the presence of the nanobubbles indicates the existence and extent of the tumor or diseased tissue.
FILED	Tuesday, April 21, 2015
APPL NO	14/692075
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/06 (20130101) A61B 6/481 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0461 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/007 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10307709 — Method and apparatus for continuous removal of water vapors from gases

US 10307709	Baxter et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	Larry Baxter (Orem, Utah); Aaron Sayre (Spanish Fork, Utah); Stephanie Burt (Provo, Utah); Nathan Davis (Bountiful, Utah)
ASSIGNEE(S)	Sustainable Energy Solutions, LLC (Orem, Utah)
INVENTOR(S)	Larry Baxter (Orem, Utah); Aaron Sayre (Spanish Fork, Utah); Stephanie Burt (Provo, Utah); Nathan Davis (Bountiful, Utah)
ABSTRACT	A method for continuously removing water vapor from a carrier gas is disclosed. This method includes, first, causing direct contact of the carrier gas with a liquid mixture in a separation chamber, the carrier gas condensing at a lower temperature than the water vapor. A combination of chemical effects cause the water vapor to condense, complex, or both condense and complex with the liquid mixture. The liquid mixture is chosen from the group consisting of: first, a combination of components that can be maintained in a liquid phase at a temperature below the water vapor's condensation point, whereby the water vapor condenses into the liquid mixture; second, a combination of components where at least one component forms a chemical complex with the water vapor and thereby extracts at least a portion of the water vapor from the carrier gas; and third, a combination of components that can both be maintained in a liquid phase at a temperature below the water vapor's condensation point, and wherein at least one component forms a chemical complex with the water vapor and thereby extracts at least a portion of the water vapor from the carrier gas. The liquid mixture is then reconstituted after passing through the separation chamber by a chemical separation process chosen to remove an equivalent amount of the water vapor from the liquid mixture as was removed from the carrier gas. The reconstituted liquid mixture is restored to temperature and pressure through heat exchange, compression, and expansion, as necessary, in preparation for recycling back to the separation chamber. The liquid mixture is then returned to the separation chamber. In this manner, the carrier gas leaving the exchanger has between 1% and 100% of the water vapor removed.
FILED	Thursday, January 19, 2017
APPL NO	15/410106
ART UNIT	1776 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 5/003 (20130101) B01D 5/0027 (20130101) B01D 5/0054 (20130101) B01D 5/0087 (20130101) B01D 53/263 (20130101) Original (OR) Class B01D 53/265 (20130101) B01D 2252/30 (20130101) B01D 2252/103 (20130101) B01D 2252/504 (20130101) B01D 2258/0283 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 3/106 (20130101) C10L 2290/12 (20130101) C10L 2290/541 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308761 — Methods for polymer synthesis

US 10308761	Allen et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	Saudi Aramco Technologies Company (Dhahran, Saudi Arabia)
ASSIGNEE(S)	Saudi Aramco Technologies Company (Dhahran, Saudi Arabia)
INVENTOR(S)	Scott D. Allen (Ithaca, New York); Christopher A. Simoneau (Ithaca, New York); William D. Keefe (Ithaca, New York); Jeff R. Conuel (Ithaca, New York)
ABSTRACT	The present invention provides methods for reducing induction periods in epoxide-CO₂copolymerizations. In certain embodiments, the methods include the step of contacting an epoxide with CO₂in the presence of two catalysts: an epoxide hydrolysis catalyst and an epoxide CO₂copolymerization catalyst. In another aspect, the invention provides catalyst compositions comprising a mixture of an epoxide hydrolysis catalyst and an epoxide CO₂copolymerization catalyst.
FILED	Friday, December 02, 2016
APPL NO	15/368144
ART UNIT	1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 64/34 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10308921 — Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same

US 10308921	Tang et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Novozymes, Inc. (Davis, California); Novozymes A/S (Bagsvaerd, Denmark)
ASSIGNEE(S)	Novozymes, Inc. (Davis, California)
INVENTOR(S)	Lan Tang (Beijing, China PRC); Ye Liu (Beijing, China PRC); Yu Zhang (Beijing, China PRC); Junxin Duan (Beijing, China PRC); Tarana Shaghasi (Dixon, California)
ABSTRACT	The present invention provides isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides, catalytic domains, cellulose binding domains and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains.
FILED	Wednesday, October 31, 2012
APPL NO	14/352875
ART UNIT	1663 — Plants
CURRENT CPC	Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Peptides C07K 14/37 (20130101) C07K 2319/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/244 (20130101) C12N 9/2405 (20130101) Original (OR) Class C12N 9/2434 (20130101) C12N 9/2437 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) C12P 19/14 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/17 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308948 — Method of increasing expression of nucleic acid molecules in plants using multiple transcription units

US 10308948	Howard et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Applied Biotechnology Institute, Inc. (San Luis Obsipo, California)
ASSIGNEE(S)	Applied Biotechnology Institute, Inc. (San Luis Obispo, California)
INVENTOR(S)	John Howard (Cayucos, California); Erin Egelkrout (San Luis Obispo, California); Celine Hayden (San Luis Obispo, California)
ABSTRACT	A method of increasing expression of a product encoded by a nucleic acid molecule is provided where in one embodiment multiple plant transcription units comprising a promoter and the nucleic acid molecule are provided. In another embodiment multiple plant transcription units are provided where each promoter is different from the other. In an embodiment the multiple plant transcription units may comprise two, three, four or more plant transcription units. In another embodiment the promoter may be selected from an embryo promoter. Another embodiment provides the promoter may be a globulin promoter. A further embodiment provides the product encoded may be selected from hepatitis b, aprotinin, or a cellulase. Still further embodiments provide the product may be selected from the cellulases E1 and CBH1.
FILED	Thursday, October 18, 2012
APPL NO	13/654673
ART UNIT	1661 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/8216 (20130101) Original (OR) Class C12N 15/8234 (20130101) C12N 15/8257 (20130101) C12N 15/8258 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309655 — Cooling system for fuel nozzles within combustor in a turbine engine

US 10309655	Laster et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Siemens Energy, Inc. (Orlando, Florida)
ASSIGNEE(S)	SIEMENS ENERGY, INC. (Orlando, Florida)
INVENTOR(S)	Walter Ray Laster (Oviedo, Florida); Scott M. Martin (Daytona Beach, Florida); Juan Enrique Portillo Bilbao (Oviedo, Florida); Jacob William Hardes (Charlotte, North Carolina); Timothy A. Fox (Hamilton, Canada)
ABSTRACT	A cooling system for a fuel system in a turbine engine that is usable to cool a fuel nozzle is disclosed. The cooling system may include one or more cooling system housings positioned around the fuel nozzle, such that the cooling system housing forms a cooling chamber defined at least partially by an inner surface of the cooling system housing and an outer surface of the fuel nozzle. The fuel nozzle may extend into a combustor chamber formed at least in part by a combustor housing. The fuel nozzle may include one or more fuel exhaust orifices with an opening in an outer surface of the fuel nozzle and configured to exhaust fluids unrestricted by the housing forming the cooling system cooling chamber. The cooling system may provide cooling fluids to cool the fuel nozzle within the cooling system cooling chamber regardless of whether the fuel nozzle is in use.
FILED	Tuesday, August 26, 2014
APPL NO	15/500954
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/30 (20130101) F02C 7/22 (20130101) F02C 7/222 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/02 (20130101) F23R 3/06 (20130101) F23R 3/16 (20130101) F23R 3/34 (20130101) F23R 3/045 (20130101) F23R 3/283 (20130101) Original (OR) Class F23R 3/286 (20130101) F23R 3/346 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309727 — Multi-stage circulating fluidized bed syngas cooling

US 10309727	Liu et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Southern Company (Birmingham, Alabama)
ASSIGNEE(S)	Southern Company (Birmingham, Alabama)
INVENTOR(S)	Guohai Liu (Birmingham, Alabama); Pannalal Vimalchand (Birmingham, Alabama); Xiaofeng Guan (Birmingham, Alabama); WanWang Peng (Birmingham, Alabama)
ABSTRACT	A method and apparatus for cooling hot gas streams in the temperature range 800° C. to 1600° C. using multi-stage circulating fluid bed (CFB) coolers is disclosed. The invention relates to cooling the hot syngas from coal gasifiers in which the hot syngas entrains substances that foul, erode and corrode heat transfer surfaces upon contact in conventional coolers. The hot syngas is cooled by extracting and indirectly transferring heat to heat transfer surfaces with circulating inert solid particles in CFB syngas coolers. The CFB syngas coolers are staged to facilitate generation of steam at multiple conditions and hot boiler feed water that are necessary for power generation in an IGCC process. The multi-stage syngas cooler can include internally circulating fluid bed coolers, externally circulating fluid bed coolers and hybrid coolers that incorporate features of both internally and externally circulating fluid bed coolers.
FILED	Thursday, September 22, 2016
APPL NO	15/272667
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/86 (20130101) C10J 2300/093 (20130101) C10J 2300/1884 (20130101) C10J 2300/1892 (20130101) Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide C10K 3/005 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 13/00 (20130101) Original (OR) Class F28D 15/00 (20130101) F28D 21/0001 (20130101) F28D 2021/0075 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 20/16 (20130101) Y02E 20/18 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309833 — Room-temperature quantum noise limited spectrometry and methods of the same

US 10309833	Stevens et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Charles G. Stevens (Danville, California); Joseph W. Tringe (Walnut Creek, California); Christopher T. Cunningham (Livermore, California)
ABSTRACT	According to one embodiment, a method of forming a plasmonic condensing lens for room temperature quantum noise limited (QNL) infrared (IR) spectrometry includes: forming a silicon cone on a substrate; coating the silicon cone with a highly reflective material; and modifying the silicon cone using focused ion beam (FIB) modification to permit transmittance of light through the silicon cone.
FILED	Monday, April 23, 2018
APPL NO	15/960350
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) G01J 3/453 (20130101) Original (OR) Class G01J 3/4338 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/35 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309881 — Methods and apparatus for preparing aqueous specimens for electron microscopy using volatile surfactants

US 10309881	Glaeser et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Robert M. Glaeser (Berkeley, California); Bong-Gyoon Han (Castro Valley, California)
ABSTRACT	This disclosure provides systems, methods, and apparatus related to the preparation of electron microscopy specimens. In one aspect, a method includes providing an electron microscopy grid. An aqueous suspension including an electron microscopy sample is deposited on the electron microscopy grid. A portion of the aqueous suspension is removed from the electron microscopy grid. A volatile surfactant is contacted to the aqueous suspension. A thickness of aqueous suspension is allowed to decrease over a period of time. The aqueous suspension is then frozen.
FILED	Tuesday, June 28, 2016
APPL NO	15/194777
ART UNIT	2881 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 1/42 (20130101) Original (OR) Class G01N 1/405 (20130101) G01N 2001/4061 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309902 — Characterization of trace crystallinity by second harmonic generation microscopy

US 10309902	Simpson et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) Food and Drug Administration (FDA) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
INVENTOR(S)	Garth Jason Simpson (West Lafayette, Indiana); Paul David Schmitt (Zionsville, Indiana)
ABSTRACT	A method for quantifying crystallinity within a sample using second harmonic generation microscopy is described herein. In one aspect, a method for reducing the timeframe for accelerated stability testing of amorphous solid dispersions of active pharmaceutical ingredients though identifying regions of interest to quantify crystallinity and composition is presented herein.
FILED	Monday, September 28, 2015
APPL NO	15/514893
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Original (OR) Class G01N 21/636 (20130101) G01N 23/207 (20130101) G01N 2223/606 (20130101) G01N 2223/612 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309932 — Apparatus and method for acoustic monitoring of steam quality and flow

US 10309932	Sinha et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Los Alamos National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Dipen N. Sinha (Los Alamos, New Mexico); Cristian Pantea (Los Alamos, New Mexico)
ABSTRACT	An apparatus and method for noninvasively monitoring steam quality and flow and in pipes or conduits bearing flowing steam, are described. By measuring the acoustic vibrations generated in steam-carrying conduits by the flowing steam either by direct contact with the pipe or remotely thereto, converting the measured acoustic vibrations into a frequency spectrum characteristic of the natural resonance vibrations of the pipe, and monitoring the amplitude and/or the frequency of one or more chosen resonance frequencies, changes in the steam quality in the pipe are determined. The steam flow rate and the steam quality are inversely related, and changes in the steam flow rate are calculated from changes in the steam quality once suitable calibration curves are obtained.
FILED	Monday, August 15, 2016
APPL NO	15/237522
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/666 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/036 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10310100 — Radiation detector

US 10310100	Taleyarkhan
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Rusi P. Taleyarkhan (Lafayette, Indiana)
ABSTRACT	Alpha particle detecting devices are disclosed that have a chamber that can hold a fluid in a tensioned metastable state. The chamber is tuned with a suitable fluid and tension such that alpha emitting materials such as radon and one or more of its decay products can be detected. The devices can be portable and can be placed in areas, such as rooms in dwellings or laboratories and used to measure radon in these areas, in situ and in real time. The disclosed detectors can detect radon at and below 4 pCi/L in air; also, at and below 4,000 pCi/L or 300 pCi/L in water. When the fluid is tensioned the presence of radon can be determined by the formation of bubbles which give off detectable signals including a shock wave, light-beam cutoff, or a light burst, any of which can be measured to derive information on radon and progeny radioactivity levels in air or water.
FILED	Monday, June 26, 2017
APPL NO	15/633185
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Nuclear or X-radiation G01T 1/18 (20130101) Original (OR) Class G01T 1/178 (20130101) G01T 5/06 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 47/001 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10310981 — Method and apparatus for performing memory prefetching

US 10310981	Eckert et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Advanced Micro Devices, Inc. (Sunnyvale, California)
ASSIGNEE(S)	ADVANCED MICRO DEVICES, INC. (Sunnyvale, California)
INVENTOR(S)	Yasuko Eckert (Bellevue, Washington); Nuwan Jayasena (Sunnyvale, California); Reena Panda (Austin, Texas); Onur Kayiran (Sunnyvale, California); Michael W. Boyer (Bellevue, Washington)
ABSTRACT	A method and apparatus for performing memory prefetching includes determining whether to initiate prefetching. Upon a determination to initiate prefetching, a first memory row is determined as a suitable prefetch candidate, and it is determined whether a particular set of one or more cachelines of the first memory row is to be prefetched.
FILED	Monday, September 19, 2016
APPL NO	15/268953
ART UNIT	2135 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 12/0862 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10310997 — System and method for dynamically allocating memory to hold pending write requests

US 10310997	Farahani et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Advanced Micro Devices, Inc. (Sunnyvale, California)
ASSIGNEE(S)	Advanced Micro Devices, Inc. (Santa Clara, California)
INVENTOR(S)	Amin Farmahini Farahani (Sunnyvale, California); David A. Roberts (Sunnyvale, California); Nuwan Jayasena (Sunnyvale, California)
ABSTRACT	A processing system employs a memory module as a temporary write buffer to store write requests when a write buffer at a memory controller reaches a threshold capacity, and de-allocates the temporary write buffer when the write buffer capacity falls below the threshold. Upon receiving a write request, the memory controller stores the write request in a write buffer until the write request can be written to main memory. The memory controller can temporarily extend the memory controller's write buffer to the memory module, thereby accommodating temporary periods of high memory activity without requiring a large permanent write buffer at the memory controller.
FILED	Thursday, September 22, 2016
APPL NO	15/273013
ART UNIT	2135 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 12/0802 (20130101) G06F 13/1673 (20130101) Original (OR) Class G06F 2212/60 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312527 — Energy storage device comprising a polyurethane separator

US 10312527	Madabusi et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Chemtura Corporation (Middlebury, Connecticut)
ASSIGNEE(S)	LANXESS SOLUTIONS US INC. (Middlebury, Connecticut)
INVENTOR(S)	Venkatramanan K. Madabusi (Naugatuck, Connecticut); Kevin Jackson (Norwood, Massachusetts); George Brereton (Mahopac, New York)
ABSTRACT	Energy storage devices are improved by incorporating polyurethane separators, which separators comprise polyurethane polymers prepared by curing a polycarbonate based polyurethane prepolymer, which polyurethane polymers often further comprise metal or ammonium salts and are often swelled by an organic solvent.
FILED	Monday, October 12, 2015
APPL NO	14/880300
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/20 (20130101) H01M 2/145 (20130101) H01M 2/1653 (20130101) H01M 8/18 (20130101) H01M 8/20 (20130101) H01M 8/188 (20130101) H01M 8/0239 (20130101) Original (OR) Class H01M 2250/20 (20130101) H01M 2250/30 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 90/18 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 90/32 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312541 — Polyol-based compositions comprising cationic group-functionalized polyphenylene polymers

US 10312541	Kim
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Yu Seung Kim (Los Alamos, New Mexico)
ABSTRACT	Disclosed herein are embodiments of compositions comprising polyols and cationic group-functionalized polyphenylene polymers suitable for use in electrochemical systems. The disclosed composition exhibit improved dispersion properties and further provide anion exchange polymer membranes exhibited improved chemical and mechanical properties. Also disclosed herein are methods of making and using the disclosed compositions.
FILED	Thursday, July 07, 2016
APPL NO	15/204523
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/13 (20170101) B01J 47/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/10 (20130101) C08G 2261/51 (20130101) C08G 2261/143 (20130101) C08G 2261/148 (20130101) C08G 2261/312 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2256 (20130101) C08J 2365/02 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/881 (20130101) H01M 8/1023 (20130101) Original (OR) Class H01M 8/1081 (20130101) H01M 2008/1095 (20130101) H01M 2300/0082 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/56 (20151101)
VIEW PATENT	@ USPTO: Full Text PDF

10312657 — Coherent combining pulse bursts in time domain

US 10312657	Galvanauskas
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Almantas Galvanauskas (Ann Arbor, Michigan)
ABSTRACT	A beam combining and pulse stacking technique is provided that enhances laser pulse energy by coherent stacking pulse bursts (i.e. non-periodic pulsed signals) in time domain. This energy enhancement is achieved by using various configurations of Fabry-Perot, Gires-Tournois and other types of resonant cavities, so that a multiple-pulse burst incident at either a single input or multiple inputs of the system produces an output with a solitary pulse, which contains the summed energy of the incident multiple pulses from all beams. This disclosure provides a substantial improvement over conventional coherent-combining methods in that it achieves very high pulse energies using a relatively small number of combined laser systems, thus providing with orders of magnitude reduction in system size, complexity, and cost compared to current combining approaches.
FILED	Wednesday, October 04, 2017
APPL NO	15/724723
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 27/1006 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/005 (20130101) H01S 3/23 (20130101) H01S 3/1062 (20130101) Original (OR) Class H01S 3/1307 (20130101) H01S 3/2308 (20130101) H01S 3/2383 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312830 — Electrostatic generator/motor rotor electrode system suitable for installation on the outer surface of an EMB rotor

US 10312830	Post et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Richard F Post (Walnut Creek, California); Lisle B. Hagler (Livermore, California)
ABSTRACT	Electrostatic generator electrodes mounted on the outer surface of a fiber-composite rotor. The conducting strips are mounted with a slight tilt in angle such that the electrodes will experience no tension or compression effects as the rotor spins up or slows down. The compression would come about from effects associated with the Poisson Ratio. This change can eliminate any metal fatigue or loss of bonding that might have arisen if the electrodes were to be aligned with the axis.
FILED	Monday, May 16, 2016
APPL NO	15/156280
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Electric Machines Not Otherwise Provided for H02N 1/08 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10313438 — Partitioned key-value store with one-sided communications for secondary global key lookup by range-knowledgeable clients

US 10313438	Bent et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	EMC Corporation (Hopkinton, Massachusetts)
ASSIGNEE(S)	EMC Corporation (Hopkinton, Massachusetts); Triad National Security, LLC (Los Alamos, New Mexico); UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	John M. Bent (Los Alamos, New Mexico); Sorin Faibish (Newton, Massachusetts); Gary Grider (Los Alamos, New Mexico); Aaron Torres (Los Alamos, New Mexico); Stephen W. Poole (Knoxville, Tennessee)
ABSTRACT	Partitioned key-value stores with one-sided communications are provided for secondary global key lookup by range-knowledgeable clients. A secondary global lookups is performed in a partitioned key-value store by receiving a request from an application for a secondary global key; accessing metadata to identify a first server storing the secondary global key; instructing the identified first server to store a first value corresponding to the requested secondary global key into a memory address of the client; and returning program control to the application, wherein the first server identifies a primary key corresponding to the requested secondary global key and instructs a second server storing the corresponding primary key to store a second value corresponding to the primary key into the memory address of the client. The second server stores the second value corresponding to the primary key into the first memory address of the client.
FILED	Monday, December 30, 2013
APPL NO	14/143758
ART UNIT	2459 — Computer Networks
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 67/1097 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10314157 — Resonant Klynac (combined klystron and linac in a bi-resonant structure)

US 10314157	Carlsten et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Bruce Carlsten (Los Alamos, New Mexico); Kimberley Nichols (Los Alamos, New Mexico)
ABSTRACT	Provided is a klynac including: a klystron input cell configured to form a first resonant circuit; a klystron output cell; and a plurality of linac cells configured to form a second resonant circuit with the klystron output cell.
FILED	Wednesday, August 30, 2017
APPL NO	15/691499
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 25/10 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/08 (20130101) Original (OR) Class H05H 7/18 (20130101) H05H 7/22 (20130101) H05H 2007/084 (20130101) H05H 2007/225 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10314176 — Contact assembly

US 10314176	Hatch
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Kansas City National Security Campus (KCNSC) NNSA Critical Mission Site Operated by Honeywell Federal Manufacturing and Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S)	Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S)	Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S)	Stephen McGarry Hatch (Blue Springs, Missouri)
ABSTRACT	An electrical contact assembly includes an electrically nonconductive base, a first electrical contact supported by the base and a second electrical contact supported by the base such that the first contact and the second contact are separated by a space. The first electrical contact is configured to engage a first external conductive circuit element and the a second electrical contact is configured to engage a second external conductive circuit element. The first contact and the second contact are configured such that a portion of the first contact and a portion of the second contact converge as the base moves in a first direction relative to the first and second external conductive circuit elements and diverge as the base moves in a second direction relative to the first and second external conductive circuit elements.
FILED	Tuesday, January 08, 2013
APPL NO	13/736696
ART UNIT	2868 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 1/0416 (20130101) G01R 27/02 (20130101) Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 12/714 (20130101) H01R 12/7082 (20130101) H01R 13/24 (20130101) H01R 13/41 (20130101) H01R 13/193 (20130101) H01R 2201/20 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/184 (20130101) H05K 3/22 (20130101) Original (OR) Class H05K 3/325 (20130101) H05K 2201/1059 (20130101) H05K 2201/10189 (20130101) H05K 2201/10962 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49124 (20150115)
VIEW PATENT	@ USPTO: Full Text PDF

National Science Foundation (NSF)

10307340 — Devices for clearing blockages in artificial and natural lumens

US 10307340	Bagwell et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Science Foundation (NSF)
APPLICANT(S)	Actuated Medical, Inc. (Bellefonte, Pennsylvania)
ASSIGNEE(S)	Actuated Medical, Inc. (Bellefonte, Pennsylvania)
INVENTOR(S)	Roger B Bagwell (Bellefonte, Pennsylvania); Ryan S Clement (State College, Pennsylvania); Katherine M Erdley (Boalsburg, Pennsylvania); Maureen L Mulvihill (Bellefonte, Pennsylvania); Casey A Scruggs (Middleburg, Pennsylvania); Douglas R Dillon (Port Matilda, Pennsylvania); Timothy J Higgins (Mingoville, Pennsylvania)
ABSTRACT	An occlusion clearing device for a patient has a housing with a motor(s) that generates repetitive motion, which is reciprocating, rotational or both. A clearing stem including a sheath that has a lumen, wherein aspiration is conducted through the sheath lumen. A wire is located in the sheath lumen and receives repetitive motion from the controller. The sheath terminates in a sheath end having at least one sheath opening. The wire terminates in a wire tip, which may be flat, helical, or tubular. The wire tip is positioned within the sheath end, in proximity to the sheath opening(s), and movement of the wire tip and/or sheath end relative to each other creates shearing forces that break up an adjacent occlusion.
FILED	Friday, July 29, 2016
APPL NO	15/223787
ART UNIT	3781 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/22 (20130101) A61B 17/3207 (20130101) A61B 17/22012 (20130101) A61B 17/320758 (20130101) A61B 17/320783 (20130101) A61B 90/70 (20160201) A61B 2017/00477 (20130101) A61B 2017/00685 (20130101) A61B 2017/00876 (20130101) A61B 2017/22014 (20130101) A61B 2017/22079 (20130101) A61B 2017/320012 (20130101) A61B 2017/320028 (20130101) A61B 2017/320733 (20130101) A61B 2017/320775 (20130101) A61B 2090/034 (20160201) A61B 2090/701 (20160201) A61B 2217/005 (20130101) A61B 2217/007 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 15/0003 (20130101) A61J 15/0026 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/0084 (20130101) A61M 3/0279 (20130101) A61M 25/00 (20130101) A61M 25/0082 (20130101) A61M 39/00 (20130101) A61M 2025/0019 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307594 — Analog front-end circuitry for biphasic stimulus signal delivery finding use in neural stimulation

US 10307594	Pepin et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Washington (Seattle, Washington)
ASSIGNEE(S)	University of Washington (Seattle, Washington)
INVENTOR(S)	Eric Pepin (Seattle, Washington); Jacques Christophe Rudell (Seattle, Washington)
ABSTRACT	Front-end analog circuitry is described based on a sink-regulated H-bridge topology for delivery of biphasic stimulus signals that may be useful in neurostimulation. Stimulus current may be supplied using fully-integrated dynamic voltage supplies (DVSs), which may be controlled in closed-loop to have an output voltage approximately equal to the voltage of the electrode each supplies stimulus to. The stimulus waveform may be regulated by a single, low-voltage current-digital-to-analog converter (current-DAC), which can safely interface with the electrodes (which may be at high voltages) via high-voltage adapter (HVA) circuits. Example analog front-end circuitry may utilize the balancing stimulus current to discharge the electrode-tissue interface impedance (Z_E). In some examples, only after full (or sufficient) Z_Edischarge has been detected is a DVS used to supply the remaining balancing stimulus.
FILED	Friday, June 17, 2016
APPL NO	15/186170
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0529 (20130101) A61N 1/0551 (20130101) A61N 1/36125 (20130101) Original (OR) Class A61N 1/36139 (20130101) A61N 1/36157 (20130101) A61N 1/37205 (20130101) A61N 1/37211 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307750 — Production of oil by pyrolysis of coal

US 10307750	Boldor et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Dorin Boldor (Baton Rouge, Louisiana); Daniel Hayes (State College, Pennsylvania)
ASSIGNEE(S)	Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana)
INVENTOR(S)	Dorin Boldor (Baton Rouge, Louisiana); Daniel Hayes (State College, Pennsylvania)
ABSTRACT	Catalysts useful in transforming biomass to bio-oil are disclosed, as are methods for making such catalysts, and methods of transforming biomass to bio-oil. The catalysts are especially useful for, but are not limited to, microwave- and induction-heating based pyrolysis of biomass, solid waste, and other carbon containing materials into bio-oil. The catalysts can also be used for upgrading the bio-oil to enhance fuel quality.
FILED	Thursday, June 21, 2018
APPL NO	16/014137
ART UNIT	1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/40 (20130101) B01J 23/42 (20130101) B01J 23/48 (20130101) B01J 23/52 (20130101) B01J 23/70 (20130101) B01J 29/40 (20130101) B01J 29/44 (20130101) B01J 31/00 (20130101) B01J 35/023 (20130101) B01J 35/0033 (20130101) B01J 37/06 (20130101) B01J 37/12 (20130101) B01J 37/16 (20130101) B01J 37/0209 (20130101) B01J 37/0217 (20130101) B01J 37/0219 (20130101) B01J 37/0221 (20130101) B01J 37/0225 (20130101) Original (OR) Class B01J 37/0226 (20130101) B01J 37/0228 (20130101) B01J 37/0246 (20130101) B01J 37/349 (20130101) B01J 2229/32 (20130101) Destructive Distillation of Carbonageous Materials for Production of Gas, Coke, Tar, or Similar Materials C10B 19/00 (20130101) C10B 53/02 (20130101) C10B 57/06 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 1/06 (20130101) C10G 1/086 (20130101) C10G 3/44 (20130101) C10G 3/47 (20130101) C10G 15/08 (20130101) C10G 2300/1011 (20130101) C10G 2400/04 (20130101) Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide C10K 3/02 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/14 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 30/20 (20151101)
VIEW PATENT	@ USPTO: Full Text PDF

10307941 — Methods of forming dry adhesive structures

US 10307941	Sitti et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	CARNEGIE MELLON UNIVERSITY, a Pennsylvania Non-Profit Corporation (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
INVENTOR(S)	Metin Sitti (Pittsburgh, Pennsylvania); Michael Murphy (Arlington, Massachusetts); Burak Aksak (Lubbock, Texas)
ABSTRACT	Methods of forming dry adhesives including a method of making a dry adhesive including applying a liquid polymer to the second end of the stem, molding the liquid polymer on the stem in a mold, wherein the mold includes a recess having a cross-sectional area that is less than a cross-sectional area of the second end of the stem, curing the liquid polymer in the mold to form a tip at the second end of the stem, wherein the tip includes a second layer stem; corresponding to the recess in the mold, and removing the tip from the mold after the liquid polymer cures.
FILED	Thursday, May 12, 2016
APPL NO	15/153165
ART UNIT	1744 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 1/005 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 39/10 (20130101) B29C 39/24 (20130101) B29C 39/42 (20130101) B29C 39/123 (20130101) B29C 41/20 (20130101) Original (OR) Class B29C 43/18 (20130101) B29C 43/021 (20130101) B29C 2043/185 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/00 (20130101) B29K 2105/20 (20130101) B29K 2105/0058 (20130101) B29K 2105/0097 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/20 (20180101) C09J 175/04 (20130101) C09J 2201/626 (20130101) C09J 2475/00 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/23929 (20150401) Y10T 428/23957 (20150401) Y10T 428/24479 (20150115)
VIEW PATENT	@ USPTO: Full Text PDF

10308774 — Polycarbonate containing compounds and methods related thereto

US 10308774	Harth et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Eva M. Harth (Nashville, Tennessee); David M. Stevens (Nashville, Tennessee)
ABSTRACT	Disclosed herein are crosslinked polycarbonates, composition thereof and methods thereof. The crosslinked polycarbonates can be prepared from allyl or epoxy polycarbonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED	Monday, February 27, 2017
APPL NO	15/443456
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/19 (20130101) A61K 9/5146 (20130101) A61K 9/5192 (20130101) A61K 47/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) A61L 31/06 (20130101) A61L 31/16 (20130101) A61L 31/146 (20130101) A61L 2300/412 (20130101) A61L 2300/416 (20130101) A61L 2400/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/34 (20130101) C08G 59/66 (20130101) C08G 59/504 (20130101) C08G 64/42 (20130101) C08G 64/0216 (20130101) C08G 64/0241 (20130101) C08G 64/0291 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 3/246 (20130101) Original (OR) Class C08J 2369/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/37 (20130101) Compositions of Macromolecular Compounds C08L 69/00 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308947 — Methods and compositions for multiplex RNA guided genome editing and other RNA technologies

US 10308947	Yang et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania)
ASSIGNEE(S)	The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Yinong Yang (State College, Pennsylvania); Kabin Xie (State College, Pennsylvania)
ABSTRACT	The invention includes materials and methods to generate numerous small RNAs from one polynucleotide construct (synthetic gene) to facilitate RNA-guided multiplex genome editing, modification, inhibition of expression and other RNA-based technologies. The synthetic gene/polynucleotide construct encodes polycistronic RNA components separated by tRNAs, and preferably also includes regulatory components such as a promoter or terminator to form an expression cassette. Once transcribed in a cell, the transcript is processed by the cell to multiple RNA molecules by the endogenous tRNA processing system. The system can be used for any RNA based gene manipulation method including RNA-mediated genome editing, artificial microRNA mediated gene silencing, small RNA mediated genetic manipulation, double-stranded RNA mediated gene silencing, antisense mechanisms and the like.
FILED	Friday, October 16, 2015
APPL NO	14/885140
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/8213 (20130101) Original (OR) Class C12N 15/8216 (20130101) C12N 15/8218 (20130101) C12N 2310/10 (20130101) C12N 2310/20 (20170501) C12N 2310/51 (20130101) C12N 2330/31 (20130101) C12N 2330/51 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309921 — Label-free electrochemical biosensor

US 10309921	Bhansali et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Shekhar Bhansali (Weston, Florida); Abhay Vasudev Mallari (Hillsboro, Oregon)
ASSIGNEE(S)	THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida)
INVENTOR(S)	Shekhar Bhansali (Weston, Florida); Abhay Vasudev Mallari (Hillsboro, Oregon)
ABSTRACT	The current invention pertains to electrochemical biosensors. The electrochemical biosensor of the current invention comprises: a) a sensing electrode having attached to its surface a binding agent capable of specifically binding to the analyte to form a binding agent-analyte complex and wherein the binding of the analyte to the binding agent alters the electron transfer properties at the sensing electrode surface thereby providing a change in the electrochemical response at the sensing electrode surface proportional to the number of binding agent-analyte complexes, and b) a test equipment capable of measuring the electrochemical response at the sensing electrode surface. The binding agent can be a binding protein, an antibody, or an aptamer, and the analyte can be a biomolecule. Accordingly, the current invention provides a method of detecting the presence or assessing the likelihood of development of a disease associated with an abnormal level of a biomolecule in a subject.
FILED	Tuesday, March 03, 2015
APPL NO	14/636758
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3271 (20130101) G01N 27/3272 (20130101) G01N 27/3275 (20130101) Original (OR) Class G01N 33/5438 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309924 — Floating gate based sensor apparatus and related floating gate based sensor applications

US 10309924	Jayant et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)	Cornell University (Ithaca, New York)
INVENTOR(S)	Krishna Jayant (Ithaca, New York); Edwin C. Kan (Ithaca, New York)
ABSTRACT	A floating gate based sensor apparatus includes at least two separate electrical bias components with respect to a floating gate based sensor surface within the floating gate based sensor apparatus. By including the at least two electrical bias components, the floating gate based sensor apparatus provides enhanced capabilities for biomaterial and non-biomaterial detection and manipulation while using the floating gate based sensor apparatus.
FILED	Monday, June 09, 2014
APPL NO	14/896010
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/703 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 2527/119 (20130101) C12Q 2565/607 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4145 (20130101) Original (OR) Class G01N 27/4146 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/42328 (20130101) H01L 29/42364 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10310181 — χ⁽²⁾modulators and related devices with barium titanate photonic crystal waveguides

US 10310181	Wessels et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS) Division of Industrial Innovation and Partnerships (IIP) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Bruce W. Wessels (Wilmette, Illinois); Zhifu Liu (Wilmette, Illinois); Peter D. Girouard (Wrentham, Massachusetts)
ABSTRACT	Barium titanate thin film waveguides and related modulator and devices with photonic crystal structures to promote wide bandwidths, low operating voltages and small footprint.
FILED	Monday, April 17, 2017
APPL NO	15/731097
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/1225 (20130101) Original (OR) Class G02B 6/12007 (20130101) G02B 6/29352 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/035 (20130101) G02F 1/065 (20130101) G02F 1/2257 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10310883 — Integrated configuration engine for interference mitigation in cloud computing

US 10310883	Maji et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Amiya Kumar Maji (West Lafayette, Indiana); Subrata Mitra (West Lafayette, Indiana); Saurabh Bagchi (West Lafayette, Indiana)
ABSTRACT	A cloud computing system which is configured to monitor operating status of a plurality of virtual computing machines running on a physical computing machine, wherein said monitoring includes monitoring a cycles per instruction (CPI) parameter and a cache miss rate (CMR) parameter of at least one of the plurality of virtual computing machines. The system detects interference in the operation of the at least one virtual machine, with the detection including determining when at least one of the CPI and CMR values exceed a predetermined threshold. When interference is detected, the system reconfigures a load balancing module associated with the virtual machine in question to send fewer requests to the virtual machine.
FILED	Wednesday, July 06, 2016
APPL NO	15/203733
ART UNIT	2196 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 9/5083 (20130101) G06F 9/45558 (20130101) Original (OR) Class G06F 2009/4557 (20130101) G06F 2009/45591 (20130101) G06F 2009/45595 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10311356 — Unsupervised behavior learning system and method for predicting performance anomalies in distributed computing infrastructures

US 10311356	Gu et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF)
APPLICANT(S)	North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)	North Carolina State University (Raleigh, North Carolina)
INVENTOR(S)	Xiaohui Gu (Raleigh, North Carolina); Daniel Dean (Raleigh, North Carolina)
ABSTRACT	An unsupervised behavior learning system and method for predicting anomalies in a distributed computing infrastructure. The distributed computing infrastructure includes a plurality of computer machines. The system includes a first computer machine and a second computer machine. The second computer machine is configured to generate a model of normal and anomalous behavior of the first computer machine, where the model is based on unlabeled training data. The second computer machine is also configured to acquire real-time data of system level metrics of the first machine; determine whether the real-time data is normal or anomalous based on a comparison of the real-time data to the model; and predict a future failure of the first computer machine based on multiple consecutive comparisons of the real-time data to the model. Upon predicting a future failure of the first computer machine, generate a ranked set of system-level metrics which are contributors to the predicted failure of the first computer machine, and generate an alarm that includes the ranked set of system-level metrics. The model of normal and anomalous behavior may include a self-organizing map.
FILED	Monday, September 08, 2014
APPL NO	14/480270
ART UNIT	2124 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10311865 — System and method for automated speech recognition

US 10311865	Jin et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania)
INVENTOR(S)	Dezhe Jin (State College, Pennsylvania); Phillip Baker Schafer (State College, Pennsylvania)
ABSTRACT	A method of recognizing speech. The method includes the steps of obtaining an auditory signal; processing the auditory signal into a plurality of frequency components; processing the plurality of frequency components using a plurality of feature detectors, each feature detector producing a feature detector response; generating a spike for each instance in which a feature detector response identifies a characteristic auditory feature to produce a test spike pattern for the auditory signal; and comparing the test spike pattern to a plurality of predetermined spike patterns corresponding to a plurality of speech elements to determine whether the auditory signal includes one of the plurality of speech elements.
FILED	Tuesday, October 14, 2014
APPL NO	15/029510
ART UNIT	2658 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/02 (20130101) G10L 15/08 (20130101) G10L 15/20 (20130101) Original (OR) Class G10L 15/063 (20130101) G10L 15/142 (20130101) G10L 25/21 (20130101) G10L 25/51 (20130101) G10L 25/87 (20130101) G10L 2015/027 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312066 — Generation of digital waveforms with high resolution duty cycle

US 10312066	Reilly et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI)
APPLICANT(S)	Washington State University (Pullman, Washington)
ASSIGNEE(S)	Washington State University (Pullman, Washington)
INVENTOR(S)	Peter T. A. Reilly (Pullman, Washington); Brian Herbert Clowers (Pullman, Washington); Zachary Philip Gotlib (Pullman, Washington); Nathan Michael Hoffman (Pullman, Washington)
ABSTRACT	Systems and methods for generating digital waveforms with high-resolution duty cycles are disclosed. A smoothed sinusoidal waveform set to a voltage other than ground may be generated and/or received. A rectangular waveform may be generated based on the sinusoidal waveform using a comparator. The rectangular waveform may be utilized to adjust the duty cycle of a current applied to a mass analyzer to improve duty-cycle resolution of a mass analyzer of a mass spectrometer.
FILED	Thursday, April 19, 2018
APPL NO	15/957812
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) H01J 49/0031 (20130101) Original (OR) Class H01J 49/34 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312081 — Synthesis of metal oxide surfaces and interfaces with crystallographic control using solid-liquid-vapor etching and vapor-liquid-solid growth

US 10312081	Guiton et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (Lexington, Kentucky)
INVENTOR(S)	Beth S. Guiton (Lexington, Kentucky); Lei Yu (Lexington, Kentucky)
ABSTRACT	The present invention provides integrated nanostructures comprising a single-crystalline matrix of a material A containing aligned, single-crystalline nanowires of a material B, with well-defined crystallographic interfaces are disclosed. The nanocomposite is fabricated by utilizing metal nanodroplets in two subsequent catalytic steps: solid-liquid-vapor etching, followed by vapor-liquid-solid growth. The first etching step produces pores, or “negative nanowires” within a single-crystalline matrix, which share a unique crystallographic direction, and are therefore aligned with respect to one another. Further, since they are contained within a single, crystalline, matrix, their size and spacing can be controlled by their interacting strain fields, and the array is easily manipulated as a single entity—addressing a great challenge to the integration of freestanding nanowires into functional materials. In the second, growth, step, the same metal nanoparticles are used to fill the pores with single-crystalline nanowires, which similarly to the negative nanowires have unique growth directions, and well-defined sizes and spacings. The two parts of this composite behave synergistically, since this nanowire-filled matrix contains a dense array of well-defined crystallographic interfaces, in which both the matrix and nanowire materials convey functionality to the material. The material of either one of these components may be chosen from a vast library of any material able to form a eutectic alloy with the metal in question, including but not limited to every material thus far grown in nanowire form using the ubiquitous vapor-liquid-solid approach. This has profound implications for the fabrication of any material intended to contain a functional interface, since high interfacial areas and high quality interfacial structure should be expected. Technologies to which this simple approach could be applied include but are not limited to p-n junctions of solar cells, battery electrode arrays, multiferroic materials, and plasmonic materials.
FILED	Tuesday, December 06, 2016
APPL NO	15/370041
ART UNIT	1713 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 1/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/0243 (20130101) H01L 21/02381 (20130101) H01L 21/02414 (20130101) H01L 21/02433 (20130101) H01L 21/02521 (20130101) H01L 21/02554 (20130101) H01L 21/02603 (20130101) Original (OR) Class H01L 21/02639 (20130101) H01L 21/02645 (20130101) H01L 21/02653 (20130101) H01L 31/18 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312436 — Ground state artificial skyrmion lattices at room temperature

US 10312436	Gilbert et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, None)
INVENTOR(S)	Dustin Gilbert (Davis, California); Kai Liu (Davis, California)
ABSTRACT	A method for fabricating artificial skyrmions and skyrmion lattices with a stable ground state at room temperature and in the absence of magnetic fields is provided. The lattices are formed by patterning vortex-state nanodots over macroscopic areas on top of an underlayer with perpendicular magnetic anisotropy (PMA); and preparing artificial skyrmion lattices using ion irradiation to suppress PMA in the underlayer and allow imprinting of the vortex structure from the nanodots to form the skyrmion lattices. Alternatively the skyrmions can be formed by ion-irradiating select asymmetric nanodot regions of the PMA underlayer, leading to planar skyrmions without nanodot protrusions. These artificial skyrmions can be used for low dissipation information storage, such as magnetic memory, logic devices and sensors.
FILED	Friday, January 26, 2018
APPL NO	15/880916
ART UNIT	2812 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 25/00 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3286 (20130101) H01F 41/14 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 43/08 (20130101) H01L 43/10 (20130101) H01L 43/12 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10312993 — Cooperative clustering for enhancing MU-massive-MISO-based UAV communication

US 10312993	Rupasinghe et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Nadisanka Rupasinghe (Raleigh, North Carolina); Ismail Guvenc (Miramar, Florida); Ahmed Salah Ibrahim Mohamed (Miami, Florida)
ASSIGNEE(S)	The Florida International University Board of Trustees (Miami, Florida)
INVENTOR(S)	Nadisanka Rupasinghe (Raleigh, North Carolina); Ismail Guvenc (Miramar, Florida); Ahmed Salah Ibrahim Mohamed (Miami, Florida)
ABSTRACT	Methods, apparatuses, and systems for organizing data delivering unmanned aerial vehicles (UAVs) are provided. Inter-cluster coordinators can organize data delivering unmanned aerial vehicle base stations (UAV-BSs). Various beamforming techniques (e.g., LZFBF and ZFBF) can be incorporated, and the inter-cluster coordinator can operate on a base station that serves as a controlling network node.
FILED	Friday, October 28, 2016
APPL NO	15/337346
ART UNIT	2647 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/122 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/104 (20130101) Transmission H04B 7/0452 (20130101) H04B 7/18506 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

National Aeronautics and Space Administration (NASA)

10306984 — Toroidal support structures

US 10306984	Jones et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Marshall Space Flight Center (MSFC)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Rodney H. Jones (Huntsville, Alabama); Zachary S. Hopkins (Madison, Alabama); Murray S. Edmondson (Madison, Alabama); James B. Weathers (Madison, Alabama); Shawn E. Mills (Owens Cross Roads, Alabama)
ABSTRACT	Provided are toroidal support structures and assemblies comprising these structures. A toroidal support structure comprises one or more side panels forming a tubular ring and one or more floor panels forming a planar ring. These rings define the toroidal shape of the structure. The structure also comprises multiple isolating linear support components connected to a top edge of the tubular ring. During installation of the structure, the isolating linear support components are attached to a mounting base for supporting the structure relative to the base, while providing thermal isolation to the rings and preventing their mechanical distortion. As such, a toroidal support structure can be attached to various types of mounting bases, such as a cryogenic tank of a spacecraft. Both rings provide supporting and mounting surfaces for equipment, cables, and pipes, while the toroidal opening allows external components to protrude through the support structure.
FILED	Tuesday, December 20, 2016
APPL NO	15/384660
ART UNIT	3632 — Static Structures, Supports and Furniture
CURRENT CPC	Tables; Desks; Office Furniture; Cabinets; Drawers; General Details of Furniture A47B 95/00 (20130101) Original (OR) Class Cosmonautics; Vehicles or Equipment Therefor B64G 1/22 (20130101) B64G 1/64 (20130101) B64G 1/402 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308365 — Fully integrated hybrid electric jet engine

US 10308365	Cantemir
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Codrin-Gruie Cantemir (Columbus, Ohio)
ASSIGNEE(S)	Codrin-Gruie (CG) Cantemir (Columbus, Ohio)
INVENTOR(S)	Codrin-Gruie Cantemir (Columbus, Ohio)
ABSTRACT	Disclosed is a high-power electric motor and its fabrication technology. The motor and its distributed power electronics are all being fully integrated in a conventional turbofan engine. The rotor drives directly (with no gears) the LP shaft of the jet engine while requiring minimal modification to a basic jet engine and without distortion to the nacelle geometry. In principle such a configuration should be suitable for a power level of 10 to 50 MW, which makes it fully capable of providing a standard flight envelope by only using electric energy.
FILED	Wednesday, October 12, 2016
APPL NO	15/291271
ART UNIT	3649 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/16 (20130101) Original (OR) Class B64D 27/24 (20130101) B64D 2027/026 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 15/10 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 6/00 (20130101) F02C 7/32 (20130101) Jet-propulsion Plants F02K 3/00 (20130101) F02K 3/06 (20130101) F02K 5/00 (20130101) Non-positive-displacement Pumps F04D 19/02 (20130101) F04D 27/009 (20130101) F04D 29/053 (20130101) Pumping of Fluid by Direct Contact of Another Fluid or by Using Inertia of Fluid to be Pumped; Siphons F04F 5/20 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/76 (20130101) Dynamo-electric Machines H02K 1/146 (20130101) H02K 3/12 (20130101) H02K 3/18 (20130101) H02K 3/28 (20130101) H02K 3/50 (20130101) H02K 3/524 (20130101) H02K 7/14 (20130101) H02K 9/06 (20130101) H02K 11/33 (20160101) H02K 21/225 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308377 — Propellant tank and loading for electrospray thruster

US 10308377	Lozano et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Paulo C. Lozano (Arlington, Massachusetts); Corey Patrick Fucetola (Somerville, Massachusetts)
ABSTRACT	Methods and apparatus of adding propellant to a thruster assembly are described. A first end of a beaker is disposed in an opening of the tank, where the beaker contains propellant and the first end of the beaker includes a breakaway bottom. The thruster assembly and beaker are placed in a first environment, where the first environment is substantially a vacuum and/or an environment composed substantially of gases that can be absorbed by the propellant. A plunger in the beaker is depressed to cause the breakaway bottom of the beaker to break and the propellant to flow into the tank of the thruster assembly. The thruster assembly is removed from the first environment and the beaker is removed from the opening. A cap is added to complete the assembly. The assembly contains a vent to allow gases to escape the interior of the tank.
FILED	Wednesday, April 08, 2015
APPL NO	14/681264
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/405 (20130101) Original (OR) Class Producing a Reactive Propulsive Thrust, Not Otherwise Provided for F03H 1/0012 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10309376 — Alpha-stream convertor

US 10309376	Dyson et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Administrator of National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Rodger W. Dyson (Elyria, Ohio); Geoffrey A. Bruder (Parma Heights, Ohio)
ABSTRACT	A thermo-acoustic engine and/or cooler is provided and includes an elongated tubular body, multiple regenerators disposed within the body, multiple heat exchangers disposed within the body, where at least one heat exchanger is disposed adjacent to each of the multiple regenerators, multiple transducers axially disposed at each end of the body, and an acoustic wave source generating acoustic waves. At least one of the acoustic waves is amplified by one of the regenerators and at least another acoustic wave is amplified by a second one of regenerators.
FILED	Friday, September 18, 2015
APPL NO	14/858424
ART UNIT	3748 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/00 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10309651 — Injectors for multipoint injection

US 10309651	Prociw et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Glenn Research Center (GLENN)
APPLICANT(S)	Delavan Inc (West Des Moines, Iowa)
ASSIGNEE(S)	DELAVAN INC (West Des Moines, Iowa)
INVENTOR(S)	Lev Alexander Prociw (Johnston, Iowa); Jason Ryon (Carlisle, Iowa)
ABSTRACT	An injector for a multipoint combustor system includes an inner air swirler which defines an interior flow passage and a plurality of swirler inlet ports in an upstream portion thereof. The inlet ports are configured and adapted to impart swirl on flow in the interior flow passage. An outer air cap is mounted outboard of the inner swirler. A fuel passage is defined between the inner air swirler and the outer air cap, and includes a discharge outlet between downstream portions of the inner air swirler and the outer air cap for issuing fuel for combustion. The outer air cap defines an outer air circuit configured for substantially unswirled injection of compressor discharge air outboard of the interior flow passage.
FILED	Tuesday, August 25, 2015
APPL NO	14/835654
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/22 (20130101) Burners F23D 11/107 (20130101) F23D 2900/11101 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/10 (20130101) F23R 3/12 (20130101) F23R 3/14 (20130101) Original (OR) Class F23R 3/28 (20130101) F23R 3/30 (20130101) F23R 3/286 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10310186 — Method of engineering the dispersion of whispering gallery mode resonators and the resonators with dispersion engineered by the method

US 10310186	Grudinin et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Ivan S. Grudinin (Pasadena, California); Nan Yu (Arcadia, California); Lukas M. Baumgartel (Portland, Oregon)
ABSTRACT	A method for fabricating a resonator structure, comprising engineering dispersion of electromagnetic radiation guided along a boundary of an axially symmetric substrate, the engineering comprising micro-structuring a geometry of the boundary, wherein the structure defines a waveguide for electromagnetic radiation.
FILED	Monday, March 14, 2016
APPL NO	15/069725
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/138 (20130101) G02B 6/29341 (20130101) Original (OR) Class G02B 27/0012 (20130101) Electric Digital Data Processing G06F 17/50 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Agriculture (USDA)

10306887 — Composition and methods for modulation of the octopamine receptor and its homologs

US 10306887	Han
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Minority Health and Health Disparities (NIMHD) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Kyung-an Han (El Paso, Texas)
ASSIGNEE(S)	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMS (Austin, Texas)
INVENTOR(S)	Kyung-an Han (El Paso, Texas)
ABSTRACT	Embodiments of the invention are directed of compositions for activation or inhibition of the Octβ2 receptor and uses thereof. The inventors have discovered that the beta adrenergic-like octopamine receptor Octβ2 serves as a key signaling molecule for ovulation and recruits protein kinase A and Ca2+/calmodulin-sensitive kinase II as downstream effectors for this activity. Octβ2R homozygous mutant females are sterile, and display normal courtship, copulation, sperm storage and post-mating rejection behavior but were unable to lay eggs.
FILED	Tuesday, August 04, 2015
APPL NO	15/501504
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 33/04 (20130101) A01N 33/06 (20130101) A01N 43/50 (20130101) A01N 45/02 (20130101) A01N 47/22 (20130101) Original (OR) Class Peptides C07K 14/43563 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5041 (20130101) G01N 2333/43552 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308947 — Methods and compositions for multiplex RNA guided genome editing and other RNA technologies

US 10308947	Yang et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania)
ASSIGNEE(S)	The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Yinong Yang (State College, Pennsylvania); Kabin Xie (State College, Pennsylvania)
ABSTRACT	The invention includes materials and methods to generate numerous small RNAs from one polynucleotide construct (synthetic gene) to facilitate RNA-guided multiplex genome editing, modification, inhibition of expression and other RNA-based technologies. The synthetic gene/polynucleotide construct encodes polycistronic RNA components separated by tRNAs, and preferably also includes regulatory components such as a promoter or terminator to form an expression cassette. Once transcribed in a cell, the transcript is processed by the cell to multiple RNA molecules by the endogenous tRNA processing system. The system can be used for any RNA based gene manipulation method including RNA-mediated genome editing, artificial microRNA mediated gene silencing, small RNA mediated genetic manipulation, double-stranded RNA mediated gene silencing, antisense mechanisms and the like.
FILED	Friday, October 16, 2015
APPL NO	14/885140
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/8213 (20130101) Original (OR) Class C12N 15/8216 (20130101) C12N 15/8218 (20130101) C12N 2310/10 (20130101) C12N 2310/20 (20170501) C12N 2310/51 (20130101) C12N 2330/31 (20130101) C12N 2330/51 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10308950 — Methods for increasing oil content in plant tissues by suppressing hydrophobic lipid droplet protein

US 10308950	Chapman et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	University of North Texas (Denton, Texas); The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia); Robert Mullen (Denton, Texas); Michal Pyc (Denton, Texas)
ASSIGNEE(S)	University of North Texas (Denton, Texas); The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S)	Kent Chapman (Denton, Texas); Robert Mullen (Denton, Texas); Michal Pyc (Denton, Texas); John M. Dyer (Denton, Texas)
ABSTRACT	The present disclosure relates to increasing oil content in plants through manipulating expression of proteins, namely At5g16550 proteins. At5g16550 proteins are lipid droplet proteins. Plants having reduced expression of At5g16550 proteins demonstrate cytoplasmic lipid droplets (LDs) that are increased in size, resulting in greater overall oil content in the plant cells.
FILED	Thursday, June 15, 2017
APPL NO	15/624495
ART UNIT	1663 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/10 (20130101) Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8247 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10308989 — Aptamers with binding affinity to norovirus

US 10308989	Jaykus et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI)
APPLICANT(S)	North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)	NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
INVENTOR(S)	Lee-Ann Jaykus (Durham, North Carolina); Blanca Irene Escudero-Abarca (Raleigh, North Carolina); Matthew D. Moore (Morrisville, North Carolina); Helen Rawsthorne (Nottinghamshire, United Kingdom)
ABSTRACT	The instant disclosure provides norovirus binding aptamers, compositions comprising such aptamers, and methods of using and producing such aptamers. The aptamers are useful, for example, for detecting the presence of norovirus in test samples, for capturing and/or concentrating norovirus from test samples, for evaluating the efficacy of therapeutic agents in patients diagnosed with a norovirus infection, and for evaluating the efficacy of norovirus vaccines.
FILED	Friday, June 12, 2015
APPL NO	15/317002
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 2310/16 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Original (OR) Class C12Q 1/6834 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) G01N 33/56983 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Veterans Affairs (DVA)

10307272 — Method for using a model-based controller for a robotic leg

US 10307272	Herr et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Hugh M. Herr (Somerville, Massachusetts); Hartmut Geyer (Pittsburgh, Pennsylvania); Michael Frederick Eilenberg (Cambridge, Massachusetts)
ABSTRACT	A model-based neuromechanical controller for a robotic limb having at least one joint includes a finite state machine configured to receive feedback data relating to the state of the robotic limb and to determine the state of the robotic limb, a muscle model processor configured to receive state information from the finite state machine and, using muscle geometry and reflex architecture information and a neuromuscular model, to determine at least one desired joint torque or stiffness command to be sent to the robotic limb, and a joint command processor configured to command the biomimetic torques and stiffnesses determined by the muscle model processor at the robotic limb joint. The feedback data is preferably provided by at least one sensor mounted at each joint of the robotic limb. In a preferred embodiment, the robotic limb is a leg and the finite state machine is synchronized to the leg gait cycle.
FILED	Thursday, November 03, 2016
APPL NO	15/342661
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/64 (20130101) A61F 2/66 (20130101) A61F 2/68 (20130101) Original (OR) Class A61F 2/605 (20130101) A61F 5/0123 (20130101) A61F 5/0127 (20130101) A61F 2002/701 (20130101) A61F 2002/704 (20130101) A61F 2002/705 (20130101) A61F 2002/741 (20130101) A61F 2002/745 (20130101) A61F 2002/747 (20130101) A61F 2002/764 (20130101) A61F 2002/7625 (20130101) A61F 2002/7635 (20130101) A61F 2002/7645 (20130101) A61F 2005/0155 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) B25J 9/1075 (20130101) B25J 9/1633 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

10307411 — Use of cotinine in treating or preventing neurogenesis deficits and enhancing neurogenesis

US 10307411	Moran et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	Department of Veterans Affairs (Washington, District of Columbia); University of South Florida (Tampa, Florida)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida)
INVENTOR(S)	Valentina Echeverria Moran (Largo, Florida); Doreen Appunn (Tampa, Florida)
ABSTRACT	A method of inhibiting or treating chemotherapy-induced cognitive dysfunction comprising administering a therapeutically effective amount of cotinine to a cancer patient experiencing chemotherapy-induced cognitive dysfunction.
FILED	Monday, May 01, 2017
APPL NO	15/583937
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/444 (20130101) A61K 31/454 (20130101) Original (OR) Class A61K 31/4545 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10307423 — FBXO3 inhibitors

US 10307423	Chen et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Beibei Chen (Wexford, Pennsylvania); Rama K. Mallampalli (Sewickley, Pennsylvania)
ABSTRACT	A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R¹-R¹⁰are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R³or R⁸is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.
FILED	Monday, April 25, 2016
APPL NO	15/138120
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/341 (20130101) A61K 31/381 (20130101) A61K 31/402 (20130101) A61K 31/427 (20130101) A61K 31/435 (20130101) A61K 31/444 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4178 (20130101) A61K 31/4418 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 11/06 (20180101) A61P 19/00 (20180101) A61P 25/00 (20180101) A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 211/01 (20130101) C07C 211/53 (20130101) C07C 229/38 (20130101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 211/14 (20130101) C07D 213/06 (20130101) C07D 213/36 (20130101) C07D 213/38 (20130101) C07D 231/12 (20130101) C07D 233/61 (20130101) C07D 233/64 (20130101) C07D 239/26 (20130101) C07D 265/30 (20130101) C07D 277/28 (20130101) C07D 295/135 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) Technologies for Adaptation to Climate Change Y02A 50/411 (20180101) Y02A 50/473 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

U.S. State Government

10309994 — Estimating photovoltaic energy through averaged irradiance observations with the aid of a digital computer

US 10309994	Hoff
FUNDED BY	U.S. State Government State of California California Public Utilities Commission (PUC)
APPLICANT(S)	Clean Power Research, L.L.C. (Napa, California)
ASSIGNEE(S)	Clean Power Research, L.L.C. (Napa, California)
INVENTOR(S)	Thomas E. Hoff (Napa, California)
ABSTRACT	The accuracy of photovoltaic simulation modeling is predicated upon the selection of a type of solar resource data appropriate to the form of simulation desired. Photovoltaic power simulation requires irradiance data. Photovoltaic energy simulation requires normalized irradiation data. Normalized irradiation is not always available, such as in photovoltaic plant installations where only point measurements of irradiance are sporadically collected or even entirely absent. Normalized irradiation can be estimated through several methodologies, including assuming that normalized irradiation simply equals irradiance, directly estimating normalized irradiation, applying linear interpolation to irradiance, applying linear interpolation to clearness index values, and empirically deriving irradiance weights. The normalized irradiation can then be used to forecast photovoltaic fleet energy production.
FILED	Monday, April 24, 2017
APPL NO	15/495892
ART UNIT	2863 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 21/1331 (20130101) Original (OR) Class Meteorology G01W 1/02 (20130101) G01W 1/12 (20130101) Electric Digital Data Processing G06F 17/11 (20130101) G06F 17/16 (20130101) G06F 17/5009 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) G06Q 50/04 (20130101) G06Q 50/06 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/383 (20130101) H02J 2003/007 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 50/00 (20130101) H02S 50/15 (20141201) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/563 (20130101) Y02E 60/76 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 90/30 (20151101) Systems Integrating Technologies Related to Power Network Operation, Communication or Information Technologies for Improving the Electrical Power Generation, Transmission, Distribution, Management or Usage, i.e Smart Grids Y04S 40/22 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312355 — Tunnel field-effect transistor (TFET) with lateral oxidation

US 10312355	Lee et al.
FUNDED BY	U.S. State Government State of Texas
APPLICANT(S)	The Board of Regents of The University of Texas System (Austin, Texas)
ASSIGNEE(S)	The Board of Regents of the University of Texas System (Austin, Texas)
INVENTOR(S)	Jack C. Lee (Austin, Texas); Han Zhao (Austin, Texas)
ABSTRACT	A vertical-mode tunnel field-effect transistor (TFET) is provided with an oxide region that may be laterally positioned relative to a source region. The oxide region operates to reduce a tunneling effect in a tunnel region underlying a drain region, during an OFF-state of the TFET. The reduction in tunneling effect results in a reduction or elimination of a flow of OFF-state leakage current between the source region and the drain region. The TFET may have components made from group III-V compound materials.
FILED	Wednesday, December 06, 2017
APPL NO	15/833579
ART UNIT	2815 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/0653 (20130101) H01L 29/0895 (20130101) H01L 29/66742 (20130101) H01L 29/66977 (20130101) Original (OR) Class H01L 29/78609 (20130101) H01L 29/78618 (20130101) H01L 29/78642 (20130101) H01L 29/78681 (20130101) H01L 29/78696 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Commerce (DOC)

10312568 — Process for making a self-aligned waveguide

US 10312568	Pappas
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Commerce (Washington, District of Columbia)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Washington, District of Columbia)
INVENTOR(S)	David P. Pappas (Boulder, Colorado)
ABSTRACT	A process for making a self-aligned waveguide includes: disposing a central conductor layer on a substrate; disposing a mask layer on the central conductor layer; forming a mask from the mask layer; removing a portion of the central conductor layer; forming an undercut interposed between substrate and the mask; forming a central conductor; disposing a ground conductor layer on the mask and the substrate; removing a portion of the ground conductor layer disposed on the mask; forming a ground plane conductor from the ground conductor layer in response to removing the portion of the ground conductor layer; and removing the mask to make the self-aligned waveguide in which the undercut provides self-alignment of each of the inner walls of the ground plane conductor to each of the sidewalls of the central conductor, and the ground plane conductor is electrically isolated from the central conductor.
FILED	Thursday, December 14, 2017
APPL NO	15/841920
ART UNIT	1713 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/00 (20130101) H01P 11/001 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Department of Homeland Security (DHS)

10308927 — Processing of a modified foot-and-mouth disease virus P1 polypeptide by an alternative protease

US 10308927	Puckette et al.
FUNDED BY	Department of Homeland Security (DHS) Science and Technology Directorate (DHS-ST)
APPLICANT(S)	The United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	Michael Puckette (Waterford, Connecticut); Max Rasmussen (Guilford, Connecticut)
ABSTRACT	Polynucleotide constructs that express an engineered foot-and-mouth disease (FMDV) P1 precursor protein and a non-FMDV TEV protease and methods for safe and efficient recombinant production of FMDV antigens and immunogens. Recombinant production of FMDV antigens avoids the need to culture highly-infectious FMDV, while conventional culture methods for producing FMDV antigens rely on the native FMDV 3C protease which exerts toxic effects on host cells. The inventors have developed a new system that efficiently and safely processes FMDV P1 precursor without the FMDV 3C protease, thus avoiding the toxic effects associated with use of the 3C protease. The invention is also directed to the FMDV antigens and virus-like particles produced by this system as well as to FMDV vaccines, diagnostics and other biologics.
FILED	Tuesday, January 17, 2017
APPL NO	15/407982
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/523 (20130101) A61K 2039/5254 (20130101) A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/96 (20130101) Original (OR) Class C12N 9/506 (20130101) C12N 2770/32122 (20130101) C12N 2770/32123 (20130101) C12N 2770/32134 (20130101) C12N 2770/32151 (20130101) Enzymes C12Y 304/22044 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Transportation (USDOT)

10309431 — Methods and apparatus to control movement of a component

US 10309431	Murphy et al.
FUNDED BY	Department of Transportation (USDOT) Federal Aviation Administration (FAA)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	THE BOEING COMPANY (Chicago, Illinois)
INVENTOR(S)	Robert M. Murphy (Everett, Washington); Kelly T. Jones (Snohomish, Washington); Robert E. Fisher (Everett, Washington); Mark J. Gardner (Snohomish, Washington)
ABSTRACT	Methods and apparatus to control movement of a component are disclosed herein. An example apparatus includes a housing defining a bore and a piston disposed inside the bore. The piston is to be coupled to a movable component disposed outside of the bore. The example apparatus further includes a fluid flowline in fluid communication with a first chamber of the bore and a second chamber of the bore. The first chamber is on a first side of the piston, and the second chamber on a second side of the piston. The example apparatus also includes a valve to control fluid flow through the fluid flowline. The valve is to be in a first state to enable the piston to dampen movement of the component, and the valve is to be in a second state to enable the piston to hold the component substantially stationary.
FILED	Tuesday, April 12, 2016
APPL NO	15/096924
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 13/40 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 45/00 (20130101) B64D 2045/0085 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/00 (20130101) F15B 15/22 (20130101) Original (OR) Class F15B 15/28 (20130101) F15B 15/149 (20130101) Springs; Shock-absorbers; Means for Damping Vibration F16F 9/20 (20130101) F16F 9/46 (20130101) F16F 9/56 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Office of the Director of National Intelligence (ODNI)

10312568 — Process for making a self-aligned waveguide

US 10312568	Pappas
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Commerce (Washington, District of Columbia)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Washington, District of Columbia)
INVENTOR(S)	David P. Pappas (Boulder, Colorado)
ABSTRACT	A process for making a self-aligned waveguide includes: disposing a central conductor layer on a substrate; disposing a mask layer on the central conductor layer; forming a mask from the mask layer; removing a portion of the central conductor layer; forming an undercut interposed between substrate and the mask; forming a central conductor; disposing a ground conductor layer on the mask and the substrate; removing a portion of the ground conductor layer disposed on the mask; forming a ground plane conductor from the ground conductor layer in response to removing the portion of the ground conductor layer; and removing the mask to make the self-aligned waveguide in which the undercut provides self-alignment of each of the inner walls of the ground plane conductor to each of the sidewalls of the central conductor, and the ground plane conductor is electrically isolated from the central conductor.
FILED	Thursday, December 14, 2017
APPL NO	15/841920
ART UNIT	1713 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/00 (20130101) H01P 11/001 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10310075 — Synthetic aperture radar data compression and transmission

US 10310075	Bevier et al.
FUNDED BY
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Terence C. Bevier (Kent, Washington); Brian H. Smith (Woodinville, Washington); Ryan C. Sanchez (Seattle, Washington)
ABSTRACT	The present disclosure generally relates to techniques for processing complex-valued array data representing an image. The techniques may include obtaining an electronic representation of an array of complex numbers representing an image, converting the array of complex numbers to an array of scaled coordinate pair values in a magnitude-phase plane, replacing each coordinate pair value with data representing a respective nearest node in a quantized magnitude-phase plane, such that an array of scaled quantized coordinate value pairs is produced, arranging into a sequence of bit values ordered according to decreasing bit significance, from most-significant bit values to least-significant bit values, the scaled quantized coordinate value pairs, and transmitting the sequence of bit values to a receiver, such that the receiver rearranges and rescales the sequence of bit values and obtains the image represented by the array of complex numbers.
FILED	Monday, April 18, 2016
APPL NO	15/131545
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/90 (20130101) Original (OR) Class G01S 13/9035 (20130101) G01S 13/9094 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10310187 — Integrated optoelectronic chip and lens array

US 10310187	Numata et al.
FUNDED BY
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Hidetoshi Numata (Kawasaki, Japan); Masao Tokunari (Kawasaki, Japan)
ABSTRACT	An optoelectronic coupling system and methods of forming the same include an optoelectronic chip mounted on a substrate. The optoelectronic chip includes one or more optoelectronic components. A lower lens array is positioned over the optoelectronic chip and has a lower surface, with a first cut-away portion to accommodate the optoelectronic chip, and an upper surface that has one or more lower lenses positioned over respective optoelectronic components. An upper lens array is positioned over the lower lens array and has comprising one or more upper lenses positioned over respective lower lenses.
FILED	Tuesday, January 09, 2018
APPL NO	15/865667
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/32 (20130101) Original (OR) Class G02B 6/425 (20130101) G02B 6/428 (20130101) G02B 6/4206 (20130101) G02B 6/4214 (20130101) G02B 6/4244 (20130101) G02B 6/4246 (20130101) G02B 6/4249 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10311307 — Methods and apparatus for video wall with feed indicators

US 10311307	Gottschlich et al.
FUNDED BY
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	RAYTHEON COMPANY (Waltham, Massachusetts)
INVENTOR(S)	Susan N. Gottschlich (Marlborough, Massachusetts); Brian Stone (Woodridge, Virginia); Raimund Merkert (Ayer, Massachusetts); William Lawrence Gerecke, III (Stow, Massachusetts)
ABSTRACT	Methods and apparatus for processing video feed metadata for respective video feeds and controlling an indicator for at least one the video feeds on a video wall. The video stream indicator can allow a viewer of the video wall to reduce the likelihood of missing an event of interest in the video feeds.
FILED	Tuesday, June 23, 2015
APPL NO	14/746888
ART UNIT	2485 — Recording and Compression
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00771 (20130101) Original (OR) Class Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 13/19693 (20130101) Pictorial Communication, e.g Television H04N 5/232 (20130101) H04N 5/247 (20130101) H04N 5/2624 (20130101) H04N 5/23229 (20130101) H04N 5/23293 (20130101) H04N 7/185 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10311369 — Quantum gates via multi-step adiabatic drag

US 10311369	Epstein
FUNDED BY
APPLICANT(S)	Ryan J. Epstein (Denver, Colorado)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Ryan J. Epstein (Denver, Colorado)
ABSTRACT	Systems and methods are provided for performing a quantum gate operation. The system includes a first physical qubit, and a second physical qubit operatively coupled to the first physical qubit via a coupling mechanism. The first physical qubit, the second physical qubit, and the coupling mechanism form a logical qubit. At least one control mechanism is configured to provide a control signal to one of the first physical qubit, the second physical qubit, and the coupling mechanism as to adjust a Hamiltonian of the logical qubit.
FILED	Monday, August 01, 2016
APPL NO	15/225162
ART UNIT	2899 — Semiconductors/Memory
CURRENT CPC	Electric Digital Data Processing G06F 15/82 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10312141 — Preclean methodology for superconductor interconnect fabrication

US 10312141	Kirby et al.
FUNDED BY
APPLICANT(S)	Christopher F. Kirby (Gambrills, Maryland); Sandro J. Di Giacomo (Ellicott City, Maryland); Michael Rennie (Mechanicsville, Virginia)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Christopher F. Kirby (Gambrills, Maryland); Sandro J. Di Giacomo (Ellicott City, Maryland); Michael Rennie (Mechanicsville, Virginia)
ABSTRACT	A method is provided of forming a superconductor device interconnect structure. The method includes forming a first dielectric layer overlying a substrate, and forming a superconducting interconnect element in a first dielectric layer, such that the superconducting interconnect element has a top surface aligned with a top surface of the first dielectric layer to form a first interconnect layer. The method also includes performing a plasma clean on a top surface of the first interconnect layer, and depositing a second dielectric layer over the first dielectric layer.
FILED	Tuesday, August 16, 2016
APPL NO	15/238394
ART UNIT	2894 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02074 (20130101) H01L 21/76883 (20130101) H01L 21/76891 (20130101) Original (OR) Class H01L 23/53285 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10312142 — Method of forming superconductor structures

US 10312142	Kirby et al.
FUNDED BY
APPLICANT(S)	Christopher F. Kirby (Gambrills, Maryland); Michael Rennie (Ashland, Virginia); Daniel J. O'Donnell (Manassas, Virginia); Sandro J. Di Giacomo (Ellicott City, Maryland)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Christopher F. Kirby (Gambrills, Maryland); Michael Rennie (Ashland, Virginia); Daniel J. O'Donnell (Manassas, Virginia); Sandro J. Di Giacomo (Ellicott City, Maryland)
ABSTRACT	A method of forming a superconductor structure is provided. The method comprises forming a superconducting element in a first dielectric layer that has a top surface aligned with the top surface of the first dielectric layer, forming a second dielectric layer over the first dielectric layer and the superconducting element, and forming an opening in the second dielectric layer to a top surface of the superconducting element. The method also comprises performing a cleaning process on the top surface of the superconducting element to remove oxides formed on the top surface of the superconducting element at a first processing stage, forming a protective barrier over the top surface of the superconducting element, and moving the superconductor structure to a second processing stage for further processing.
FILED	Monday, November 28, 2016
APPL NO	15/362400
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0273 (20130101) H01L 21/02063 (20130101) H01L 21/02074 (20130101) H01L 21/3212 (20130101) H01L 21/7684 (20130101) H01L 21/7685 (20130101) H01L 21/31116 (20130101) H01L 21/76802 (20130101) H01L 21/76814 (20130101) H01L 21/76849 (20130101) H01L 21/76877 (20130101) H01L 21/76883 (20130101) H01L 21/76891 (20130101) Original (OR) Class H01L 23/66 (20130101) H01L 23/528 (20130101) H01L 23/5226 (20130101) H01L 23/53285 (20130101) H01L 39/12 (20130101) H01L 39/2406 (20130101) H01L 2223/6627 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/081 (20130101) H01P 11/003 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, June 04, 2019.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20190604.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

info@wayfinder.digital