FedInvent™ Patents

Patent Details for Tuesday, August 06, 2019

This page was updated on Monday, March 27, 2023 at 05:52 AM GMT

Department of Health and Human Services (HHS)

10368669 — System and method for stabilizing unintentional muscle movements

US 10368669	Pathak
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Anupam Pathak (Los Altos Hills, California)
ASSIGNEE(S)	Verily Life Sciences LLC (South San Francisco, California)
INVENTOR(S)	Anupam Pathak (Los Altos Hills, California)
ABSTRACT	A system and method for stabilizing a position of an object are disclosed. The system comprises a housing that includes a subsystem. The system also includes an attachment arm coupled to the housing. At least one first sensor is placed along the attachment arm, wherein the attachment arm is configured to receive the object thereto. In response to an unintentional muscle movement by a user that adversely affects the motion of the object, the subsystem stabilizes the position of the object. The method comprises providing a subsystem within a housing and coupling an attachment arm to the housing. The method also includes placing at least one first sensor along the attachment arm, wherein the attachment arm is configured to receive the object thereto. In response to an unintentional muscle movement by a user that adversely affects the motion of the object, the subsystem stabilizes the position of the object.
FILED	Friday, September 30, 2011
APPL NO	13/250000
ART UNIT	3738 — SELECT * FROM codes_techcenter;
CURRENT CPC	Household or Table Equipment A47G 21/02 (20130101) A47G 21/08 (20130101) Original (OR) Class A47G 2200/046 (20130101) Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/1101 (20130101) A61B 5/6887 (20130101) A61B 2562/0219 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/08 (20130101) A61F 4/00 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101)
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10368735 — Method and system for three-dimensional thickness mapping of corneal micro-layers and corneal diagnoses

US 10368735	Abou Shousha et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	UNIVERSITY OF MIAMI (Miami, Florida)
ASSIGNEE(S)	University of Miami (Miami, Florida)
INVENTOR(S)	Mohamed Abou Shousha (Pembroke Pines, Florida); Amr Saad Mohamed Elsawy (Miami, Florida)
ABSTRACT	Techniques for improved diagnosis, treatment, and monitoring of corneal pathologies use enhanced mapping of the cornea or corneal regions, to develop three-dimensional mapping of corneal thickness, while retaining particular corneal micro-layer thickness data. Anterior and posterior surface identifications, along with surface apex determinations, are used for registration of segmentation of these micro-layers. 3D heat maps and bull's-eye maps are generated from resulting thickness date. The maps provided enhanced evaluation and diagnosis of a corneal pathologies, such as keratoconus, pellucid marginal degeneration, post-refractive surgery ectasia, keratoglobus, corneal transplant rejection and corneal transplant failed grafts, Fuchs dystrophy, corneal limbal stem cell deficiency, dry eye syndrome, and post-corneal collagen crosslinking evaluation.
FILED	Thursday, January 11, 2018
APPL NO	15/868856
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/14 (20130101) A61B 3/0025 (20130101) Original (OR) Class A61B 3/1005 (20130101) Image Data Processing or Generation, in General G06T 3/0068 (20130101) G06T 3/4038 (20130101) G06T 5/50 (20130101) G06T 7/11 (20170101) G06T 7/0014 (20130101) G06T 7/32 (20170101) G06T 7/60 (20130101) G06T 15/04 (20130101) G06T 2207/20216 (20130101) G06T 2207/30041 (20130101)
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10368753 — Method and system for determining strain relaxation of left ventricular diastolic function

US 10368753	Venkatesh et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Bharath Ambale Venkatesh (Baltimore, Maryland); Anderson Armstrong (Baltimore, Maryland); Joao A. C. Lima (Timonium, Maryland); Chia-Ying Liu (Ellicott City, Maryland); Boaz D. Rosen (Baltimore, Maryland)
ABSTRACT	An embodiment in accordance with the present invention provides a system and method for determining cardiac events. The system and method include using an imaging modality to obtain a cardiac image of the subject. The image is then used to determine the subject's systolic, post-systolic, and early diastolic strain peaks. Additionally, a strain rate index (SRI) value is computed for the subject using the systolic, post-systolic, and early diastolic strain peaks. The SRI value can then be used to determine a level of risk of cardiac failure. Further, a likelihood of atrial fibrillation can also be determined. The SRI value and risk of cardiac event can then be used to create a treatment plan for the subject, if necessary.
FILED	Friday, November 01, 2013
APPL NO	14/439290
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/02 (20130101) Original (OR) Class A61B 5/0044 (20130101) A61B 5/046 (20130101) A61B 5/055 (20130101) A61B 5/0452 (20130101) A61B 5/7275 (20130101) A61B 5/7282 (20130101) A61B 8/485 (20130101) A61B 8/0883 (20130101) A61B 2576/023 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101)
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10368788 — System and methods for wireless drug delivery on command

US 10368788	Scherer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
INVENTOR(S)	Axel Scherer (Barnard, Vermont); Meisam Honarvar Nazari (Pasadena, California); Muhammad Mujeeb-U-Rahman (San Gabriel, California); Mehmet Sencan (Pasadena, California); Arti Gaur (Hanover, New Hampshire)
ABSTRACT	A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
FILED	Thursday, July 21, 2016
APPL NO	15/216675
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0031 (20130101) A61B 5/076 (20130101) A61B 5/1451 (20130101) A61B 5/1459 (20130101) A61B 5/1473 (20130101) Original (OR) Class A61B 5/4839 (20130101) A61B 5/14532 (20130101) A61B 5/14546 (20130101) A61B 5/14735 (20130101) A61B 5/14865 (20130101) A61B 17/3468 (20130101) A61B 2560/0219 (20130101) A61B 2562/04 (20130101) A61B 2562/028 (20130101) A61B 2562/125 (20130101) A61B 2562/0209 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/172 (20130101) A61M 5/1723 (20130101) A61M 5/14276 (20130101) A61M 2205/3523 (20130101) A61M 2205/8237 (20130101) A61M 2207/00 (20130101)
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10368831 — Waveform enhanced reflection and margin boundary characterization for ultrasound tomography

US 10368831	Duric et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Delphinus Medical Technologies, Inc. (Novi, Michigan)
ASSIGNEE(S)	Delphinus Medical Technologies, Inc. (Novi, Michigan)
INVENTOR(S)	Nebojsa Duric (Novi, Michigan); Peter J. Littrup (Novi, Michigan); Gursharan Singh Sandhu (Novi, Michigan); Mark Krycia (Novi, Michigan); Mark Sak (Novi, Michigan)
ABSTRACT	The present invention provides improved methods and systems for generating enhanced images of a volume of tissue. In an aspect, the method comprises receiving from a transducer, a plurality of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating from the acoustic signals, a first reflection rendering that characterizes sound reflection, the first reflection rendering comprising a first distribution of reflection values across a region of the volume of tissue; generating from the acoustic signals, a sound speed rendering that characterizes sound speed, the sound speed rendering comprising a distribution of sound speed values across the region; generating from the sound speed rendering, a second reflection rendering that characterizes sound reflection, the second reflection rendering comprising a second distribution of reflection values across the region; and rendering one or more combined images, based on the first reflection rendering and the second reflection rendering.
FILED	Friday, December 01, 2017
APPL NO	15/829748
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/13 (20130101) A61B 8/15 (20130101) A61B 8/085 (20130101) A61B 8/406 (20130101) A61B 8/0825 (20130101) Original (OR) Class A61B 8/5207 (20130101) A61B 8/5253 (20130101) Image Data Processing or Generation, in General G06T 5/008 (20130101) G06T 2207/10136 (20130101)
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10368956 — MR-levelcheck-2: method for localization of structures in projection images

US 10368956	Siewerdsen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Jeffrey H. Siewerdsen (Baltimore, Maryland); Wathudurage Tharindu De Silva (Baltimore, Maryland); Ali Uneri (Baltimore, Maryland); Michael Ketcha (Baltimore, Maryland); Sureerat Reaungamornrat (Baltimore, Maryland); Jean-Paul Wolinsky (Towson, Maryland)
ABSTRACT	An embodiment in accordance with the present invention provides a technique for localizing structures of interest in projection images (e.g., x-ray projection radiographs or fluoroscopy) based on structures defined in a preoperative 3D image (e.g., MR or CT). Applications include, but are not limited to, spinal interventions. The present invention achieves 3D-2D image registration (and particularly allowing use with a preoperative MR image) by segmenting the structures of interest in the preoperative 3D image and generating a simulated projection of the segmented structures to be aligned with the 2D projection image. Other applications include various clinical scenarios involving 3D-2D image registration, such as image-guided cranial neurosurgery, orthopedic surgery, biopsy, and radiation therapy.
FILED	Thursday, February 16, 2017
APPL NO	15/434123
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4566 (20130101) A61B 34/10 (20160201) A61B 90/36 (20160201) Original (OR) Class A61B 2034/105 (20160201) A61B 2034/107 (20160201) A61B 2090/367 (20160201) A61B 2090/374 (20160201) A61B 2576/02 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/10004 (20130101)
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10369045 — Micromanipulation systems and methods

US 10369045	Gonenc et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland); CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland); Carnegie Mellon University (Pittsburgh, Pennsylvania)
INVENTOR(S)	Berk Gonenc (Baltimore, Maryland); Iulian Iordachita (Lutherville-Timonium, Maryland); Russell H. Taylor (Severna Park, Maryland); Cameron Riviere (Pittsburgh, Pennsylvania); Peter Gehlbach (Monkton, Maryland); James Handa (Baltimore, Maryland)
ABSTRACT	A micromanipulation system includes a micromanipulator that includes a handpiece, and a micromanipulation tool that includes a tool shaft and is operatively connected to the handpiece. The micromanipulator further includes an actuator assembly connected to the micromanipulation tool to provide manual control of the micromanipulation tool, and a force sensing system comprising a force sensor attached to the tool shaft. The force sensing system is configured to provide an output signal that indicates a force imposed on the tool shaft. The micromanipulation system also includes a processor that is in communication with the force sensing system, and is configured to receive the output signal and compensate for forces due to actuation of the micromanipulation tool to determine a force due to interaction of the micromanipulation tool with a region of interest. The processor outputs an indication of at least one of a magnitude and a direction of the determined force.
FILED	Monday, July 27, 2015
APPL NO	14/810277
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/065 (20130101) A61B 5/489 (20130101) A61B 5/6848 (20130101) A61B 17/2909 (20130101) A61B 34/70 (20160201) A61B 34/72 (20160201) A61B 34/75 (20160201) A61B 2017/305 (20130101) A61B 2017/2902 (20130101) A61B 2017/2912 (20130101) A61B 2090/064 (20160201) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00736 (20130101) Original (OR) Class Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/246 (20130101) G01L 5/226 (20130101) G01L 25/00 (20130101)
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10369089 — Iron oxide nanoparticles and methods of use thereof

US 10369089	Koo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
INVENTOR(S)	Hyun Koo (Philadelphia, Pennsylvania); Lizeng Gao (Philadelphia, Pennsylvania); David Cormode (Philadelphia, Pennsylvania); Pratap Naha (Philadelphia, Pennsylvania)
ABSTRACT	The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth or apatitic demineralization. In particular, the presently disclosed subject matter provides a composition for the prevention and treatment of an oral disease (e.g., dental caries) that includes one or more iron oxide nanoparticles and hydrogen peroxide.
FILED	Friday, February 12, 2016
APPL NO	15/550267
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/12 (20130101) A01N 25/26 (20130101) A01N 59/00 (20130101) A01N 59/06 (20130101) A01N 59/10 (20130101) A01N 59/16 (20130101) A01N 59/16 (20130101) A01N 59/20 (20130101) A01N 59/26 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 8/19 (20130101) Original (OR) Class A61K 8/20 (20130101) A61K 8/21 (20130101) A61K 8/22 (20130101) A61K 8/24 (20130101) A61K 8/66 (20130101) A61K 8/73 (20130101) A61K 8/0245 (20130101) A61K 9/006 (20130101) A61K 9/14 (20130101) A61K 9/0063 (20130101) A61K 9/5161 (20130101) A61K 33/26 (20130101) A61K 33/26 (20130101) A61K 33/40 (20130101) A61K 33/40 (20130101) A61K 47/6923 (20170801) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2800/92 (20130101) A61K 2800/413 (20130101) A61K 2800/624 (20130101) A61K 2800/882 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 11/00 (20130101) Technologies for Adaptation to Climate Change Y02A 50/471 (20180101) Y02A 50/473 (20180101)
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10369103 — Neuroprotective liposome compositions and methods for treatment of stroke

US 10369103	Huang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Board of Regents of the University of Texas System (Austin, Texas)
ASSIGNEE(S)	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Shao-Ling Huang (Houston, Texas); Melvin E. Klegerman (Houston, Texas); Yong-Jian Geng (Houston, Texas); Hyunggun Kim (Houston, Texas); David D. McPherson (Houston, Texas)
ABSTRACT	Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.
FILED	Friday, August 09, 2013
APPL NO	14/420429
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) Original (OR) Class A61K 33/00 (20130101) A61K 41/0028 (20130101)
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10369106 — Efficient aqueous encapsulation and controlled release of bioactive agents

US 10369106	Schwendeman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The Regents of The University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Steven P. Schwendeman (Superior Township, Michigan); Ronak B. Shah (Ann Arbor, Michigan); Morgan B. Giles (Ann Arbor, Michigan); Rae Sung Chang (Ann Arbor, Michigan); Anna A. Schwendeman (Superior Township, Michigan)
ABSTRACT	A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
FILED	Monday, November 10, 2014
APPL NO	14/537716
ART UNIT	1616 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1611 (20130101) A61K 9/1623 (20130101) A61K 9/1647 (20130101) A61K 9/1652 (20130101) Original (OR) Class A61K 9/1694 (20130101) A61K 38/47 (20130101) A61K 38/1825 (20130101) A61K 38/1866 (20130101) A61K 38/2264 (20130101) Enzymes C12Y 302/01017 (20130101)
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10369125 — Method of treating renal system damage

US 10369125	Yang
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	The University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Tianxin Yang (Salt Lake City, Utah)
ABSTRACT	Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.
FILED	Thursday, April 20, 2017
APPL NO	15/492732
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/201 (20130101) Original (OR) Class A61K 31/201 (20130101) A61K 31/231 (20130101) A61K 31/231 (20130101) A61K 31/704 (20130101) A61K 31/704 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10369133 — Immunosuppressive compounds and therapeutics

US 10369133	Miller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Memphis, Tennessee); RXBIO, INC. (Johnson City, Tennessee)
ASSIGNEE(S)	THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Memphis, Tennessee)
INVENTOR(S)	Duane Douglas Miller (Collierville, Tennessee); Charles Ryan Yates (Collierville, Tennessee); Jayaprakash Pagadala (Parkland, Florida); Ram Mahato (Omaha, Nebraska); Hao Wu (Shanghai, China PRC)
ABSTRACT	Here provided are new immunosuppressive compounds and novel therapeutics for improving tissue transplantation.
FILED	Wednesday, July 23, 2014
APPL NO	14/907015
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/343 (20130101) A61K 31/343 (20130101) A61K 31/365 (20130101) Original (OR) Class A61K 31/661 (20130101) A61K 31/665 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101)
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10369150 — Benzathine analogs

US 10369150	Chen et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Beibei Chen (Sewickley, Pennsylvania); Rama K. Mallampalli (Sewickley, Pennsylvania)
ABSTRACT	A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R¹-R¹⁰are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R³or R⁸is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.
FILED	Wednesday, October 10, 2018
APPL NO	16/156902
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/341 (20130101) A61K 31/381 (20130101) A61K 31/402 (20130101) A61K 31/427 (20130101) A61K 31/435 (20130101) A61K 31/444 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4178 (20130101) A61K 31/4418 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 11/06 (20180101) A61P 19/00 (20180101) A61P 25/00 (20180101) A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 211/01 (20130101) C07C 211/53 (20130101) C07C 229/38 (20130101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 211/14 (20130101) C07D 213/06 (20130101) C07D 213/36 (20130101) C07D 213/38 (20130101) C07D 231/12 (20130101) C07D 233/61 (20130101) C07D 233/64 (20130101) C07D 239/26 (20130101) C07D 265/30 (20130101) C07D 277/28 (20130101) C07D 295/135 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) Technologies for Adaptation to Climate Change Y02A 50/411 (20180101) Y02A 50/473 (20180101)
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10369158 — Pharmaceutical packaging for estriol therapy

US 10369158	Voskuhl
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Rhonda R. Voskuhl (Los Angeles, California)
ABSTRACT	This invention relates to novel packaged pharmaceutical products for the treatment of neurodegenerative diseases, such as multiple sclerosis, and methods of using these products.
FILED	Monday, April 27, 2015
APPL NO	15/307198
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/57 (20130101) A61K 31/57 (20130101) A61K 31/566 (20130101) Original (OR) Class A61K 31/566 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10369167 — Continuously expressed therapeutic RNAs for targeted protein binding and methods for their use

US 10369167	Pang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	CITY OF HOPE (Duarte, California)
ASSIGNEE(S)	CITY OF HOPE (Duarte, California)
INVENTOR(S)	Ka Ming Pang (Arcadia, California); John J. Rossi (Azusa, California)
ABSTRACT	An RNA composition comprising an RNA aptamer and an shRNA molecule and/or an miRNA molecule are provided. The RNA composition may include an aptamer component that binds an enzymatic protein within a target cell and an shRNA and/or an miRNA component that facilitates trafficking of the aptamer within the target cell, such as, trafficking from the nucleus into the cytoplasm. The RNA aptamer and the shRNA and/or the miRNA component of the composition can be a fusion or independent molecules.
FILED	Wednesday, November 01, 2017
APPL NO	15/800836
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/7105 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 15/1132 (20130101) C12N 2310/14 (20130101) C12N 2310/16 (20130101) C12N 2310/141 (20130101) C12N 2310/322 (20130101) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2310/3533 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101)
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10369173 — Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy

US 10369173	Kreke et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Capricor, Inc. (Beverly Hills, California)
ASSIGNEE(S)	Capricor, Inc. (Beverly Hills, California)
INVENTOR(S)	Michelle Kreke (Marina del Rey, California); Rachel Smith (Cary, North Carolina)
ABSTRACT	The present disclosure relates generally to methods for the increased processing of tissue for the generation of cardiac stem cells, wherein the stem cells are suitable for use in cardiac stem cell therapy. In particular, several embodiments relate to the processing of allogeneic donor cardiac tissue for the generation of multiple patient doses of cardiac stem cells.
FILED	Monday, December 11, 2017
APPL NO	15/837549
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) A61K 35/34 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2500/32 (20130101) C12N 2501/91 (20130101) C12N 2509/00 (20130101) C12N 2523/00 (20130101)
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10369187 — Peptide regulators of JNK family kinases

US 10369187	Gurevich et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Vsevolod V. Gurevich (Nashville, Tennessee); Eugenia V. Gurevich (Nashville, Tennessee); Xuanzhi Zhan (Nashville, Tennessee)
ABSTRACT	The present disclosure relates to the fields of proliferative disorders (for example, cancer) and disorders associated with excessive cell death (for example, neurodegenerative disorders).
FILED	Friday, February 09, 2018
APPL NO	15/892853
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) Original (OR) Class A61K 38/1709 (20130101)
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10369189 — Compositions and methods for uncoupling TrkB receptor from PLC gamma 1 for the treatment of epilepsy and anxiety-like disorder

US 10369189	McNamara et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	DUKE UNIVERSITY (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	James O. McNamara (Chapel Hill, North Carolina); Xiao-Ping He (Cary, North Carolina); Yangzhong Huang (Chapel Hill, North Carolina); Bin Gu (Durham, North Carolina)
ABSTRACT	The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides that when administered disrupt the physical interaction of TrkB with its signaling effector, phospholipase Cγ1 (PLCγ1). The invention further provides method of treatment comprising administering phosphopeptides that uncouple TrkB from PLCγ1 in order to prevent and/or ameliorate nervous system disorders such as epilepsy, anxiety, and seizures.
FILED	Monday, May 19, 2014
APPL NO	14/281584
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 31/7105 (20130101) A61K 38/04 (20130101) A61K 38/04 (20130101) A61K 38/16 (20130101) Original (OR) Class A61K 38/16 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 16/2863 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101)
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10369194 — Methods to treat allergic conditions with PIM1 kinase inhibitor

US 10369194	Gelfand et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	National Jewish Health (Denver, Colorado)
ASSIGNEE(S)	National Jewish Health (Denver, Colorado)
INVENTOR(S)	Erwin W. Gelfand (Englewood, Colorado); Meiqin Wang (Glendale, Colorado)
ABSTRACT	Disclosed are methods to treat allergic conditions, including pulmonary and non-pulmonary conditions, in a subject by administering a composition that inhibits Pim kinase. Also disclosed are methods to treat allergic conditions in a subject by administering a composition that induces expression of Runx3.
FILED	Monday, July 31, 2017
APPL NO	15/664550
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/553 (20130101) A61K 31/4045 (20130101) A61K 31/7052 (20130101) A61K 38/1719 (20130101) Original (OR) Class
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10369195 — Methods and compositions for preventing and treating damage to the heart

US 10369195	John et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute on Aging (NIA)
APPLICANT(S)	MandalMed, Inc. (San Francisco, California); The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	MandalMed, Inc. (San Francisco, California); The Regents of the University of California (Oakland, California)
INVENTOR(S)	Constance M. John (San Francisco, California); Meenakshi Gaur (San Francisco, California); Matthew L. Springer (San Francisco, California); Xiaoyin Wang (San Francisco, California)
ABSTRACT	Provided herein are methods and compositions for preventing and treating damage to the heart subsequent to myocardial infarction (MI) resulting from harmful fibrotic remodeling, thereby improving cardiac function and reducing mortality from subsequent heart failure.
FILED	Tuesday, August 01, 2017
APPL NO	15/666456
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0021 (20130101) A61K 38/1732 (20130101) Original (OR) Class
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10369208 — Methods for the induction of immune responses in a subject compromising administering virus-like particles (VLPS) prepared from Chikungunya virus structural proteins

US 10369208	Nabel et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center (VRC)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
INVENTOR(S)	Gary J. Nabel (Chestnut Hill, Massachusetts); Wataru Akahata (Kensington, Maryland); Srinivas Rao (Columbia, Maryland)
ABSTRACT	The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases.
FILED	Tuesday, May 03, 2016
APPL NO	15/145483
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/5258 (20130101) A61K 2039/55566 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 7/045 (20130101) C12N 2740/16043 (20130101) C12N 2770/36123 (20130101) C12N 2770/36134 (20130101) Technologies for Adaptation to Climate Change Y02A 50/51 (20180101) Y02A 50/383 (20180101)
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10369209 — Drug target and construct for Japanese encephalitis virus infection

US 10369209	Lee
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Young-Min Lee (North Logan, Utah)
ASSIGNEE(S)	Utah State University (Cache County, Logan, Utah)
INVENTOR(S)	Young-Min Lee (North Logan, Utah)
ABSTRACT	A group of mosquito-borne flaviviruses that cause fatal encephalitis in humans is among the most important of all emerging human pathogens of global significance. This group includes Japanese encephalitis virus (JEV), West Nile virus, St. Louis encephalitis virus, and Murray Valley encephalitis virus. In the present disclosure, the first reverse genetics system has been developed for SA14-14-2, a live JE vaccine that is most commonly used in most JE-endemic areas, by constructing an infectious bacterial artificial chromosome that contains the full-length SA14-14-2 cDNA. Using this infectious SA 14-14-2 cDNA, combined with a mouse model for JEV infection, a key viral neurovirulence factor has been discovered that is a conserved single amino acid in the ij hairpin adjacent to the fusion loop of the viral E glycoprotein, which regulates viral infectivity into neurons within the central nervous system.
FILED	Friday, April 10, 2015
APPL NO	15/303375
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/525 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24111 (20130101) C12N 2770/24122 (20130101) C12N 2770/24134 (20130101) C12N 2770/24143 (20130101) C12N 2770/24152 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 2333/18 (20130101) G01N 2333/185 (20130101) G01N 2800/26 (20130101)
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10369229 — Methods and compositions for liposomal formulation of antigens and uses thereof

US 10369229	Fujii et al.
FUNDED BY	Department of Homeland Security (DHS) Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); MOLECULAR EXPRESS, INC. (Rancho Dominquez, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); MOLECULAR EXPRESS, INC. (Rancho Dominguez, California)
INVENTOR(S)	Gary Fujii (Rancho Palos Verdes, California); Francis C. Szoka (San Francisco, California); Douglas S. Watson (Harrisonburg, Virginia)
ABSTRACT	The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
FILED	Monday, April 02, 2018
APPL NO	15/943382
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 39/07 (20130101) A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 39/385 (20130101) A61K 47/543 (20170801) A61K 47/554 (20170801) A61K 47/6911 (20170801) A61K 47/6913 (20170801) Original (OR) Class A61K 2039/60 (20130101) A61K 2039/627 (20130101) A61K 2039/6018 (20130101) A61K 2039/55555 (20130101) A61K 2039/55572 (20130101) Steroids C07J 9/00 (20130101) C07J 41/0055 (20130101) C07J 43/003 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16134 (20130101) C12N 2760/16134 (20130101) C12N 2770/00011 (20130101) C12N 2770/00034 (20130101)
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10369249 — In situ solidifying complex coacervates and methods of making and using thereof

US 10369249	Stewart
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S)	University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Russell J. Stewart (Salt Lake City, Utah)
ABSTRACT	Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.
FILED	Friday, January 26, 2018
APPL NO	15/880650
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0043 (20130101) A61K 49/0054 (20130101) A61K 49/0073 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/02 (20130101) A61L 24/10 (20130101) A61L 24/0015 (20130101) A61L 24/0031 (20130101) A61L 24/0042 (20130101) A61L 24/043 (20130101) A61L 24/043 (20130101) A61L 24/046 (20130101) Original (OR) Class A61L 24/104 (20130101) A61L 2300/44 (20130101) A61L 2300/416 (20130101) A61L 2430/02 (20130101) A61L 2430/36 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1668 (20130101)
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10369255 — Scaffolds comprising nanoelectronic components for cells, tissues, and other applications

US 10369255	Lieber et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Charles M. Lieber (Lexington, Massachusetts); Jia Liu (Palo Alto, California); Bozhi Tian (Chicago, Illinois); Tal Dvir (Rishon le Zion, Israel); Robert S. Langer (Newton, Massachusetts); Daniel S. Kohane (Newton, Massachusetts)
ABSTRACT	The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.
FILED	Thursday, July 21, 2016
APPL NO	15/216068
ART UNIT	3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/02 (20130101) A61L 27/04 (20130101) A61L 27/08 (20130101) A61L 27/18 (20130101) A61L 27/025 (20130101) A61L 27/30 (20130101) A61L 27/38 (20130101) A61L 27/50 (20130101) A61L 27/56 (20130101) Original (OR) Class A61L 27/383 (20130101) A61L 27/507 (20130101) A61L 27/3826 (20130101) A61L 2400/12 (20130101) Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) C12M 35/02 (20130101)
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10369260 — Blood pump

US 10369260	Smith et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio); FOSTER-MILLER, INC. (Waltham, Massachusetts)
ASSIGNEE(S)	The Cleveland Clinic Foundation (Cleveland, Ohio)
INVENTOR(S)	William A. Smith (Lyndhurst, Ohio); Markus Lorenz (Karlsruhe, Germany); David Dudzinski (Strongsville, Ohio); Hsiang Ming Chen (Latham, New York); Peter A. Chapman, Jr. (East Schodack, New York); Charles J. Prisco (Saratoga Springs, New York); Nicholas G. Vitale (Albany, New York); Stephan Weber (Lyndhurst, Ohio)
ABSTRACT	A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).
FILED	Friday, March 06, 2015
APPL NO	14/640124
ART UNIT	3762 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/12 (20130101) A61M 1/101 (20130101) A61M 1/122 (20140204) A61M 1/125 (20140204) A61M 1/127 (20130101) A61M 1/1008 (20140204) A61M 1/1012 (20140204) A61M 1/1015 (20140204) A61M 1/1031 (20140204) Original (OR) Class
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10369360 — Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity

US 10369360	Arora et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	Rishi Arora (Chicago, Illinois); Alan Kadish (Evanston, Illinois); Jason Ng (Evanston, Illinois)
ABSTRACT	The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.
FILED	Friday, September 15, 2017
APPL NO	15/706257
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/20 (20130101) A61N 1/327 (20130101) Original (OR) Class A61N 1/0412 (20130101)
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10369381 — System and method for robust intensity-modulated proton therapy planning

US 10369381	Liu
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (Rochester, Minnesota)
ASSIGNEE(S)	Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
INVENTOR(S)	Wei Liu (Scottsdale, Arizona)
ABSTRACT	The present invention provides a system and method for generating intensity modulated proton therapy plans. The method includes receiving a representation of a subject that includes information related to target and non-target volumes of interest, and computing, using the representation and a proton beam configuration that describes a number of beamlets and their respective arrangement, a dose distribution for each one of a plurality of uncertainty scenarios. The method also includes computing a robustness index for respective locations in the target volumes of interest using the dose distributions, and optimizing an objective function to determine a set of intensity weights for each beamlet in the proton beam configuration, wherein the objective function is based at least in part on deviations of the robustness indices from a prescribed robustness index. The method further includes generating a treatment plan using the determined intensity weights.
FILED	Wednesday, September 02, 2015
APPL NO	14/843384
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/748 (20130101) A61B 5/7207 (20130101) A61B 6/032 (20130101) A61B 6/037 (20130101) A61B 6/542 (20130101) A61B 6/5217 (20130101) A61B 34/10 (20160201) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1031 (20130101) A61N 5/1039 (20130101) Original (OR) Class A61N 2005/1087 (20130101)
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10369385 — Quantitative MRI measurements near metal objects

US 10369385	Weber et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
INVENTOR(S)	Hans Weber (Menlo Park, California); Daehyun Yoon (Palo Alto, California); Valentina Taviani (Palo Alto, California); Brian A. Hargreaves (Menlo Park, California)
ABSTRACT	A method for providing at least one measurement by a magnetic resonance imaging (MRI) system of a tissue property or underlying tissue property in a region sufficiently close to a metal object, so that the metal object induces artifacts is provided. At least one magnetic resonance imaging signal from the region is acquired through the MRI system. The acquired at least one MRI signal is processed to correct for artifacts induced by the metal object. At least one tissue property or underlying tissue property measurement is extracted from the processed at least one MRI signal.
FILED	Tuesday, April 14, 2015
APPL NO	14/686455
ART UNIT	2867 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/062 (20130101) A61B 18/12 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/403 (20130101) A61N 7/02 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/4804 (20130101) G01R 33/56527 (20130101)
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10369564 — Minimally-invasive collection system for collecting biological samples for quantifying heavy metals, other toxicants, pathogens, and biomarkers

US 10369564	Funk et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	William E. Funk (Evanston, Illinois); Thomas W. McDade (Evanston, Illinois); Andrew Unger (Bethlehem, Pennsylvania)
ABSTRACT	Disclosed are devices, kits, compositions, and methods for collecting, transporting, and detecting toxicants, pathogens, and biomarkers in a biological sample. The devices, kits, compositions and methods may be utilized to collect and transport dried blood samples from a skin prick and detect toxicants, pathogens, and biomarkers in the dried blood samples.
FILED	Tuesday, May 23, 2017
APPL NO	15/602864
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/151 (20130101) A61B 5/15105 (20130101) A61B 5/15142 (20130101) A61B 5/150022 (20130101) A61B 5/150305 (20130101) A61B 5/150358 (20130101) A61B 5/150412 (20130101) A61B 5/150503 (20130101) A61B 5/150755 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) Original (OR) Class B01L 3/5055 (20130101) B01L 2200/141 (20130101) B01L 2200/185 (20130101) B01L 2200/0689 (20130101) B01L 2300/021 (20130101) B01L 2300/069 (20130101) B01L 2300/126 (20130101) B01L 2300/0681 (20130101) B01L 2300/0816 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/84 (20130101)
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10370245 — Methods and compositions using peptides and proteins with C-terminal elements

US 10370245	Ruoslahti et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Erkki Ruoslahti (Buellton, California); Tambet Teesalu (Goleta, California); Kazuki Sugahara (Goleta, California)
ASSIGNEE(S)	Sanford-Burnham Medical Research Institute (La Jolla, California)
INVENTOR(S)	Erkki Ruoslahti (Buellton, California); Tambet Teesalu (Goleta, California); Kazuki Sugahara (Goleta, California)
ABSTRACT	Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
FILED	Tuesday, June 22, 2010
APPL NO	12/821050
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/66 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Original (OR) Class
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10370333 — Sulfonamide compounds and uses as TNAP inhibitors

US 10370333	Pinkerton et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California)
ASSIGNEE(S)	SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California)
INVENTOR(S)	Anthony B. Pinkerton (La Jolla, California); Russell Dahl (La Jolla, California); Nicholas D. P. Cosford (La Jolla, California); Jose Luis Millan (La Jolla, California)
ABSTRACT	Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.
FILED	Monday, February 05, 2018
APPL NO	15/888736
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/50 (20130101) Heterocyclic Compounds C07D 213/76 (20130101) Original (OR) Class C07D 213/79 (20130101) C07D 213/80 (20130101) C07D 213/81 (20130101) C07D 213/82 (20130101) C07D 215/38 (20130101) C07D 215/48 (20130101) C07D 231/42 (20130101) C07D 237/20 (20130101) C07D 239/69 (20130101) C07D 241/22 (20130101) C07D 261/16 (20130101) C07D 263/50 (20130101) C07D 271/113 (20130101) C07D 277/52 (20130101) C07D 285/135 (20130101) C07D 333/36 (20130101) C07D 401/04 (20130101) C07D 401/12 (20130101) C07D 405/04 (20130101) C07D 405/12 (20130101) C07D 409/04 (20130101) C07D 409/12 (20130101) C07D 417/04 (20130101)
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10370348 — Tocopherol and tocopheryl quinone derivatives as correctors of lysosomal storage disorders

US 10370348	Marugan et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
INVENTOR(S)	Juan Jose Marugan (Gaithersburg, Maryland); Wei Zheng (Potomac, Maryland); Jingbo Xiao (Rockville, Maryland); John McKew (Poolesville, Maryland)
ABSTRACT	The subject invention relates to improved tocopheryl quinine derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorder, restoration of normal mitochondrial ATP production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have terminally halogenated carbon atoms.
FILED	Tuesday, May 30, 2017
APPL NO	15/608753
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/35 (20130101) A61K 31/122 (20130101) A61K 31/335 (20130101) A61K 31/352 (20130101) A61K 31/353 (20130101) A61K 31/355 (20130101) A61K 31/724 (20130101) Acyclic or Carbocyclic Compounds C07C 50/02 (20130101) C07C 50/06 (20130101) C07C 50/24 (20130101) Heterocyclic Compounds C07D 311/58 (20130101) Original (OR) Class C07D 311/72 (20130101)
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10370351 — Photoinduced electron transfer voltage-sensitive compounds

US 10370351	Miller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Evan W. Miller (Berkeley, California); Rishikesh Upendra Kulkarni (Berkeley, California)
ABSTRACT	The disclosure provides methods to synthesize photoinduced electron transfer voltage-sensitive compounds, the compounds made therefrom, and uses of the compounds thereof.
FILED	Tuesday, April 25, 2017
APPL NO	15/496897
ART UNIT	1763 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Heterocyclic Compounds C07D 219/04 (20130101) C07D 311/82 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/502 (20130101) G01N 33/542 (20130101) G01N 33/5008 (20130101) G01N 2500/10 (20130101)
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10370360 — Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof

US 10370360	Brekken et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Board of Regents of the University of Texas System (Austin, Texas); Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (Guangzhou, China PRC)
ASSIGNEE(S)	The Board of Regents of the University of Texas System (Austin, Texas); Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (Guangzhou, China PRC)
INVENTOR(S)	Rolf A. Brekken (Dallas, Texas); Ke Ding (Guangzhou, China PRC); Xiaomei Ren (Guangzhou, China PRC); Zhengchao Tu (Guangzhou, China PRC); Zhen Wang (Guangzhou, China PRC); Kristina Y. Aguilera (Dallas, Texas)
ABSTRACT	Compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in effectively inhibiting the enzymatic activity of discoidin domain receptor 1 and can be used as new therapeutic agents for preventing and treating e.g. inflammation, liver fibrosis, kidney fibrosis, lung fibrosis, skin scar, atherosclerosis, and cancer. The compound of formula I is: wherein the variables are as defined herein.
FILED	Wednesday, October 21, 2015
APPL NO	15/521107
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/337 (20130101) A61K 31/4725 (20130101) A61K 31/7068 (20130101) A61K 31/7068 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 401/04 (20130101) C07D 401/14 (20130101) Original (OR) Class
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10370385 — Tricyclic mosquitocides and methods of making and using thereof

US 10370385	Njardarson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
INVENTOR(S)	Jon Njardarson (Tucson, Arizona); Jun Isoe (Tuscon, Arizona); Roger Miesfeld (Tucson, Arizona)
ABSTRACT	Compounds that inhibit digestion in blood-ingesting pests are described herein. In one embodiment, the compounds described herein block entry of blood into the midgut and thereby inhibit digestion and nutrient processing. In another embodiment, the compounds described herein prevent pathogens contained in the blood meal from entering the midgut where they could cross the epithelial cell layer and infect the mosquito. The compounds can be administered to a population of blood-ingesting pests, such as mosquitos, directly or indirectly in an effective amount to prevent mosquitoes from transmitting diseases such as malaria, dengue fever, West Nile virus and lymphatic filariasis. Preferably, the compounds are lethal to blood-ingesting pests. The compounds can be combined with one or more excipients to prepare compositions.
FILED	Friday, July 10, 2015
APPL NO	15/325320
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/90 (20130101) Heterocyclic Compounds C07D 495/04 (20130101) Original (OR) Class
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10370391 — Hydrogen peroxide-activable, anti-oxidant compounds and methods using same

US 10370391	Kang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Chonbuk National University Industrial Cooperation Foundation (Jeonju, Jeonbuk, South Korea)
ASSIGNEE(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Chonbuk National University Industrial Cooperation Foundation (Jeonju, South Korea)
INVENTOR(S)	Peter M. Kang (Boston, Massachusetts); Dongwon Lee (Jeonbuk, South Korea); Seunggyu Park (Jeonbuk, South Korea); Dahee Jeong (Jeonbuk, South Korea)
ABSTRACT	The present invention includes 4-(hydroxymethyl)phenylboronic esters, which react with hydrogen peroxide to form 4-hydroxybenzyl alcohol, which is an anti-inflammatory and/or anti-oxidant compound, as well as microparticles and compositions thereof. In certain embodiments, the compositions of the invention may be used to treat or prevent oxidative stress and/or inflammation, including ischemic disease.
FILED	Monday, May 01, 2017
APPL NO	15/583517
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/5031 (20130101) A61K 31/69 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class
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10370393 — Stereoretentive cross-coupling of boronic acids

US 10370393	Burke et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Martin D. Burke (Champaign, Illinois); Ian Crouch (Urbana, Illinois); Jonathan Lehmann (Urbana, Illinois); Andrea Palazzolo (Urbana, Illinois); Claire Simons (Urbana, Illinois)
ABSTRACT	The present disclosure provides tri-orthoalkylphenyl phosphine catalysts of formula I wherein A is CH2, C═O, or NR^A; R¹is aryl, heteroaryl, isopropyl, tert-butyl, cycloalkyl, or heterocycloalkyl, wherein aryl, heteroaryl, cycloalkyl and heterocycloalkyl are optionally substituted; R²is H, (C₁-C₈)alkyl, (C₁-C₈)alkoxy, N(R^A)₂, or an electron withdrawing group; and each R^Ais independently H or (C₁-C₈)alkyl; that are tuned electrically and sterically.
FILED	Monday, April 23, 2018
APPL NO	15/959986
ART UNIT	1622 — Organic Chemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2404 (20130101) B01J 2231/4277 (20130101) B01J 2531/824 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 37/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) C07F 9/5022 (20130101) Original (OR) Class C07F 15/006 (20130101) C07F 15/0066 (20130101)
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10370400 — 4-methylumbelliferone derivatives for treatment for immune modulation

US 10370400	Nagy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
INVENTOR(S)	Nadine Nagy (Palo Alto, California); Jayakumar Rajadas (Cupertino, California); Paul Bollyky (Stanford, California)
ABSTRACT	This disclosure presents 4-MUG derivatives (e.g., 4-MUG ester prodrugs) that reduce or prevent HA synthesis. In some embodiments, the 4-MUG derivatives of the present disclosure can be used to suppress HA synthesis and curtail inflammation.
FILED	Friday, January 12, 2018
APPL NO	15/870755
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 11/06 (20180101) A61P 17/06 (20180101) A61P 19/02 (20180101) A61P 29/00 (20180101) A61P 37/02 (20180101) A61P 37/08 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/26 (20130101) C07H 17/075 (20130101) Original (OR) Class
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10370409 — Synthesis of libraries of peptide tertiary amides

US 10370409	Kodadek et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD)
APPLICANT(S)	The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S)	The Scripps Research Institute (La Jolla, California)
INVENTOR(S)	Thomas Kodadek (Jupiter, Florida); Yu Gao (Jupiter, Florida)
ABSTRACT	The present disclosure is directed to a novel class of peptide-like oligomers called peptide tertiary amides (PTAs) and a combinatorial library of PTAs along with synthetic routes for the preparation of large combinatorial libraries of these compounds. The peptide tertiary amides provide an exceptional source of high affinity and selective protein ligands that are useful as tools for biological research and as drug leads, among others.
FILED	Thursday, October 25, 2012
APPL NO	14/354031
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) Acyclic or Carbocyclic Compounds C07C 51/363 (20130101) C07C 51/363 (20130101) C07C 53/19 (20130101) C07C 231/02 (20130101) C07C 231/02 (20130101) C07C 237/22 (20130101) Peptides C07K 1/042 (20130101) C07K 1/047 (20130101) C07K 5/0806 (20130101) C07K 5/06026 (20130101) C07K 7/06 (20130101) Original (OR) Class C07K 14/001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101)
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10370416 — Dual purpose universal influenza vaccine confers protective immunity against anthrax

US 10370416	Zeng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Texas Tech University System (Lubbock, Texas)
ASSIGNEE(S)	Texas Tech University System (Lubbock, Texas)
INVENTOR(S)	Mingtao Zeng (El Paso, Texas); Maria T. Arevalo (Athens, Georgia); Junwei Li (El Paso, Texas)
ABSTRACT	The present invention includes antigenic fusion proteins, nucleic acids encoding the fusion proteins and methods of making and using the same, wherein the fusion protein comprises three or more different influenza A ectodomains of Matrix Protein 2 (M2e); one or more stem regions of an influenza A hemagglutinin 2 (HA2) protein; and optionally an anthrax antigen, wherein the fusion protein is immunogenic across strains.
FILED	Wednesday, March 01, 2017
APPL NO	15/446315
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/07 (20130101) A61K 39/12 (20130101) A61K 2039/70 (20130101) A61K 2039/543 (20130101) A61K 2039/572 (20130101) A61K 2039/575 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/40 (20130101) C07K 2319/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/16122 (20130101) C12N 2760/16134 (20130101) C12N 2760/16143 (20130101) C12N 2760/16162 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) G01N 33/5088 (20130101) G01N 2333/11 (20130101) G01N 2333/32 (20130101)
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10370432 — Heterologous targeting peptide grafted AAVS

US 10370432	Esteves et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Miguel Sena Esteves (Westford, Massachusetts); Sourav Roy Choudhury (Newton, Massachusetts)
ABSTRACT	The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
FILED	Friday, October 02, 2015
APPL NO	15/516582
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/0025 (20130101) A61K 48/0058 (20130101) Peptides C07K 7/00 (20130101) C07K 7/04 (20130101) C07K 14/00 (20130101) C07K 14/005 (20130101) C07K 14/075 (20130101) C07K 14/775 (20130101) Original (OR) Class C07K 19/00 (20130101) C07K 2319/01 (20130101) C07K 2319/30 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/79 (20130101) C12N 15/86 (20130101) C12N 2750/14145 (20130101) C12N 2810/85 (20130101)
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10370438 — Histamine-releasing factor (HRF), HRF-receptor and methods of modulating inflammation

US 10370438	Kawakami et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (La Jolla, California)
ASSIGNEE(S)	LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (La Jolla, California)
INVENTOR(S)	Toshiaki Kawakami (Del Mar, California); Yuko Kawakami (Del Mar, California)
ABSTRACT	Methods of treating a food allergy, allergic reactions, hypersensitivity, inflammatory responses, inflammation are provided. In one method, histamine releasing factor (HRF)/translationally controlled tumor protein (TCTP) is contacted with a compound that inhibits or reduces binding of HRF/TCTP to an immunoglobulin in order to treat the food allergy, allergic reaction, hypersensitivity, inflammatory response, or inflammation. Methods of reducing or decreasing the probability, severity, frequency, duration or preventing a subject from having an acute or chronic food allergy, allergic reaction, hypersensitivity, an inflammatory response or inflammation, are also provided. In one method, histamine releasing factor (HRF)/translationally controlled tumor protein (TCTP) is contacted with a compound that inhibits or reduces binding of HRF/TCTP to an immunoglobulin in order to reduce or decrease the probability, severity, frequency, duration or prevent a subject from having an acute or chronic food allergy, allergic reaction, hypersensitivity, an inflammatory response or inflammation.
FILED	Monday, August 18, 2014
APPL NO	14/462424
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 39/3955 (20130101) A61K 2039/505 (20130101) Peptides C07K 7/08 (20130101) C07K 14/47 (20130101) C07K 14/52 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/76 (20130101) C07K 2319/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2500/02 (20130101) G01N 2800/24 (20130101)
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10370439 — Prevention of tissue ischemia and related methods

US 10370439	Isenberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
INVENTOR(S)	Jeffrey S. Isenberg (Mt. Lebanon, Pennsylvania); David D. Roberts (Bethesda, Maryland)
ABSTRACT	Provided herein are compositions for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing CD47 and/or blocking TSP1 and/or CD47 activity or interaction. Influencing the interaction of CD47-TSP1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function. Under conditions of decreased blood flow, for instance through injury or atherosclerosis, blocking TSP1-CD47 interaction allows blood vessels to dilate and increases blood flow, tissue perfusion and tissue survival.
FILED	Monday, September 29, 2014
APPL NO	14/500861
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 48/00 (20130101) A61K 2039/505 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/12 (20130101) B01J 21/063 (20130101) B01J 23/002 (20130101) B01J 23/30 (20130101) B01J 27/188 (20130101) B01J 37/0205 (20130101) B01J 2523/00 (20130101) B01J 2523/00 (20130101) B01J 2523/00 (20130101) B01J 2523/00 (20130101) B01J 2523/15 (20130101) B01J 2523/41 (20130101) B01J 2523/51 (20130101) B01J 2523/51 (20130101) B01J 2523/69 (20130101) B01J 2523/69 (20130101) B01J 2523/69 (20130101) Acyclic or Carbocyclic Compounds C07C 45/002 (20130101) C07C 45/52 (20130101) C07C 45/52 (20130101) C07C 47/22 (20130101) C07C 51/235 (20130101) C07C 51/252 (20130101) C07C 51/252 (20130101) C07C 57/04 (20130101) C07C 253/26 (20130101) Peptides C07K 14/78 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6887 (20130101) G01N 33/6893 (20130101) G01N 2333/705 (20130101)
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10370440 — Reconstituted polypeptides

US 10370440	Koide
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Research CorporationTechnologies, Inc. (Tucson, Arizona)
ASSIGNEE(S)	Research Corporation Technologies, Inc. (Tuscon, Arizona)
INVENTOR(S)	Shohei Koide (Chicago, Illinois)
ABSTRACT	The present invention provides modified fibronectin type III (Fn3) molecules, and nucleic acid molecules encoding the modified Fn3 molecules. Also provided are methods of preparing these molecules, and kits to perform the methods.
FILED	Thursday, April 30, 2015
APPL NO	14/701331
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/78 (20130101) C07K 16/00 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/565 (20130101) C07K 2318/20 (20130101)
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10370446 — Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (PD-1) pathway

US 10370446	Freeman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Emory University (Atlanta, Georgia); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Brigham and Women's Hospital (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	Emory University (Atlanta, Georgia); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Brigham and Women's Hospital, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Gordon Freeman (Brookline, Massachusetts); Arlene Sharpe (Brookline, Massachusetts); David M. Dorfman (Brookline, Massachusetts); Rafi Ahmed (Atlanta, Georgia); Daniel Barber (Rockville, Maryland); E. John Wherry (Havertown, Pennsylvania)
ABSTRACT	The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.
FILED	Tuesday, August 30, 2016
APPL NO	15/252133
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 38/1709 (20130101) A61K 39/39 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2039/572 (20130101) A61K 2039/55516 (20130101) A61K 2039/55566 (20130101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/70 (20130101) C07K 2317/74 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/5011 (20130101) G01N 33/57484 (20130101) G01N 33/57492 (20130101) G01N 2800/26 (20130101) Technologies for Adaptation to Climate Change Y02A 50/58 (20180101) Y02A 50/412 (20180101) Y02A 50/467 (20180101)
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10370458 — Therapeutic use of mitochondria and combined mitochondrial agent

US 10370458	McCully et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) U.S. Public Health Service (USPHS)
APPLICANT(S)	Children's Medical Center Corporation (Boston, Massachusetts); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Children's Medical Center Corporation and Beth Israel (Boston, Massachusetts); Deaconess Medical Center, Inc. (Boston, Massachusetts)
INVENTOR(S)	James D. McCully (Marblehead, Massachusetts); Sidney Levitsky (Boston, Massachusetts); Douglas B. Cowan (Brighton, Massachusetts); Pedro J. del Nido (Lexington, Massachusetts); Sitaram M. Emani (Newton, Massachusetts)
ABSTRACT	The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
FILED	Friday, November 03, 2017
APPL NO	15/803543
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/42 (20130101) A61B 6/503 (20130101) A61B 8/0883 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/12 (20130101) A61K 35/28 (20130101) A61K 35/34 (20130101) A61K 47/6901 (20170801) A61K 49/0002 (20130101) A61K 49/1821 (20130101) A61K 49/1896 (20130101) A61K 51/0421 (20130101) A61K 51/1203 (20130101) A61K 51/1282 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/468 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101)
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10370488 — Stimulus-responsive poly(lactic-co-glycolic)-based polymers and nanoparticles formed therefrom

US 10370488	Almutairi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Adah Almutairi (La Jolla, California); Jason Olejniczak (San Diego, California); Minnie Chan (San Diego, California)
ABSTRACT	PLGA-based polymers include pendant nucleophiles protected with photocleavable protecting groups. Upon deprotection, the polymers degrade rapidly via intramolecular cyclization into small molecules. The polymer may be formulated as a nanoparticle, with an encapsulated payload, which may be an imaging agent, a bioactive agent or a pharmaceutical agent.
FILED	Friday, April 08, 2016
APPL NO	15/564693
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0002 (20130101) A61K 9/5153 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/685 (20130101) Original (OR) Class
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10370637 — Technology for sustaining pluripotency and improved growth of stem cells in culture

US 10370637	Talbot et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Prudence Talbot (Riverside, California); Sabrina Lin (Silverado, California); Antonio Loza (Indio, California)
ABSTRACT	A method of culturing pluripotent stem cells is provided. The method includes culturing pluripotent stem cells in a pluripotent stem cell culture medium supplemented with an additive, where the additive includes a source of acetate ions, a carboxylic acid, or a physiologically acceptable salt of the carboxylic acid, or a combination of these substances, in an amount effective to maintain the pluripotent stem cells in culture in an undifferentiated pluripotent state. Also included are pluripotent stem cell culture media and methods of making such media.
FILED	Thursday, December 15, 2016
APPL NO	15/380811
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) Original (OR) Class C12N 2501/999 (20130101)
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10370642 — Hematopoietic progenitor cell populations having affinity for E-selectin / L-selectin

US 10370642	Sackstein
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Robert Sackstein (Sudbury, Massachusetts)
ASSIGNEE(S)	Robert Sackstein (Sudbury, Massachusetts)
INVENTOR(S)	Robert Sackstein (Sudbury, Massachusetts)
ABSTRACT	The invention feature methods and compositions for treating hematopoietic disorders, inflammatory conditions, and cancer and providing stem cell therapy in a mammal.
FILED	Friday, January 16, 2015
APPL NO	14/599211
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2035/124 (20130101) Peptides C07K 14/70585 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 2501/59 (20130101) C12N 2501/90 (20130101) C12N 2501/599 (20130101) C12N 2501/724 (20130101)
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10370656 — Nucleic acid functionalized nanoparticles for therapeutic applications

US 10370656	Mirkin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) NIH Office of the Director (NIHOD)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); David A. Giljohann (Chicago, Illinois); Dwight S. Seferos (Toronto, Canada)
ABSTRACT	Materials and methods for modulating cellular uptake of functionalized nanoparticles are provided. Also provided are materials and methods for modulating the effectiveness of a therapeutic agent with a functionalized nanoparticle.
FILED	Tuesday, October 18, 2016
APPL NO	15/296387
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/351 (20130101) C12N 2320/32 (20130101)
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10370661 — Nucleic acid functionalized nanoparticles for therapeutic applications

US 10370661	Mirkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); Nathaniel L. Rosi (Chicago, Illinois); C. Shad Thaxton (Chicago, Illinois); David A. Giljohann (Chicago, Illinois)
ABSTRACT	Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.
FILED	Wednesday, July 19, 2017
APPL NO	15/654401
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/5115 (20130101) A61K 31/7088 (20130101) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/314 (20130101) C12N 2310/315 (20130101) C12N 2310/351 (20130101) C12N 2310/3181 (20130101) C12N 2320/32 (20130101)
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10370664 — Use of IKK epsilon inhibitors to activate NFAT and T cell response

US 10370664	Feng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	University of Southern California (Los Angeles, California)
ASSIGNEE(S)	University of Southern California (Los Angeles, California)
INVENTOR(S)	Pinghui Feng (La Canada, California); Junjie Zhang (Monterey Park, California); Hao Feng (Changsha, China PRC)
ABSTRACT	Disclosed herein are compositions and methods of activating nuclear factor of activated T cells (NFAT) and T cell response by inhibiting IKKε.
FILED	Friday, November 07, 2014
APPL NO	15/034529
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 31/7105 (20130101) Peptides C07K 16/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101)
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10370698 — Highly-multiplexed fluorescent imaging

US 10370698	Nolan et al.
FUNDED BY	Department of Health and Human Services (HHS) Food and Drug Administration (FDA)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Garry P. Nolan (Redwood City, California); Nikolay Samusik (Mountain View, California); Julia Kennedy-Darling (Stanford, California); Yury Goltsev (Stanford, California)
ABSTRACT	Provided herein is a method and system for analyzing a sample. In some embodiments the method makes use of a plurality of capture agents that are each linked to a different oligonucleotide and a corresponding plurality of labeled nucleic acid probes, wherein each of the labeled nucleic acid probes specifically hybridizes with only one of the oligonucleotides. The sample is labeled with the capture agents en masse, and sub-sets of the capture agents are detected using iterative cycles using corresponding subsets of the labeled nucleic acid probes.
FILED	Wednesday, July 26, 2017
APPL NO	15/660846
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class C12Q 1/6804 (20130101) C12Q 1/6813 (20130101) C12Q 1/6813 (20130101) C12Q 2525/205 (20130101) C12Q 2525/205 (20130101) C12Q 2563/131 (20130101) C12Q 2563/131 (20130101) C12Q 2565/531 (20130101) C12Q 2565/531 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 33/554 (20130101) G01N 33/5308 (20130101) G01N 33/54306 (20130101) G01N 2001/302 (20130101) G01N 2458/10 (20130101)
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10370702 — Methods of making oligonucleotide probes

US 10370702	Wu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Chao-ting Wu (Brookline, Massachusetts); Brian Beliveau (Cambridge, Massachusetts)
ABSTRACT	The present invention relates to methods of making linear nucleic acid probes using rolling circle amplification methods.
FILED	Thursday, September 22, 2016
APPL NO	15/273041
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6811 (20130101) Original (OR) Class C12Q 1/6811 (20130101) C12Q 1/6813 (20130101) C12Q 2525/131 (20130101) C12Q 2525/155 (20130101) C12Q 2531/113 (20130101) C12Q 2531/125 (20130101) C12Q 2563/107 (20130101)
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10370705 — Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes

US 10370705	Ismagilov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Chicago (Chicago, Illinois)
ASSIGNEE(S)	University of Chicago (Chicago, Illinois)
INVENTOR(S)	Rustem F. Ismagilov (Altadena, California); Feng Shen (Chicago, Illinois); Jason E. Kreutz (Chicago, Illinois); Bing Sun (Chicago, Illinois); Wenbin Du (Chicago, Illinois)
ABSTRACT	Provided are devices and methods for effecting processing of samples, including essentially isothermal amplification of nucleic acids, at multiple reaction locations in a single device. In some embodiments, the disclosed devices and methods provide for effecting parallel sample processing in several hundred locations on a single device.
FILED	Thursday, August 25, 2016
APPL NO	15/247795
ART UNIT	1799 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 13/0094 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5025 (20130101) B01L 3/502715 (20130101) B01L 3/502738 (20130101) B01L 2200/027 (20130101) B01L 2300/0864 (20130101) B01L 2300/0896 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) Original (OR) Class C12Q 1/6851 (20130101) C12Q 2531/119 (20130101) C12Q 2537/149 (20130101) C12Q 2563/159 (20130101) C12Q 2565/629 (20130101)
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10370712 — Signatures of radiation response

US 10370712	Chute et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	DUKE UNIVERSITY (Durham, North Carolina)
ASSIGNEE(S)	DUKE UNIVERSITY (Durham, North Carolina)
INVENTOR(S)	John P. Chute (Durham, North Carolina); Joseph R. Nevins (Durham, North Carolina); Joseph Lucas (Durham, North Carolina); Holly K. Dressman (Durham, North Carolina)
ABSTRACT	The present invention relates, in general, to gene expression profiles, and in particular, to a gene expression profile of an environmental exposure, ionizing radiation. The invention further relates to methods of screening patients for radiation exposure based on gene expression profiling and to kits suitable for use in such methods.
FILED	Tuesday, September 24, 2013
APPL NO	14/430635
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6813 (20130101) C12Q 1/6876 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/158 (20130101)
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10370713 — Methods of lowering the error rate of massively parallel DNA sequencing using duplex consensus sequencing

US 10370713	Salk et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute on Aging (NIA)
APPLICANT(S)	UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington)
ASSIGNEE(S)	UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington)
INVENTOR(S)	Jesse Salk (Seattle, Washington); Lawrence A. Loeb (Bellevue, Washington); Michael Schmitt (Seattle, Washington)
ABSTRACT	Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands.
FILED	Friday, August 31, 2018
APPL NO	16/120091
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class C12Q 2525/179 (20130101) C12Q 2525/185 (20130101) C12Q 2525/191 (20130101) C12Q 2525/191 (20130101) C12Q 2535/119 (20130101) C12Q 2535/119 (20130101) C12Q 2535/122 (20130101) C12Q 2563/179 (20130101) C12Q 2565/514 (20130101)
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10370715 — Methods for identifying, diagnosing, and predicting survival of lymphomas

US 10370715	Staudt et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, District of Columbia)
INVENTOR(S)	Louis M. Staudt (Bethesda, Maryland); George W. Wright (Rockville, Maryland); Sandeep Dave (Chapel Hill, North Carolina); Bruce K. Tan (Chicago, Illinois)
ABSTRACT	The invention provides methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention provides a microarray for obtaining gene expression data from a lymphoma sample. The invention also provides a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma, which is useful in developing an appropriate therapeutic approach.
FILED	Monday, December 15, 2014
APPL NO	14/570316
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) G01N 2800/60 (20130101)
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10370728 — Antibiotic susceptibility testing using probes for preribosomal RNA

US 10370728	Haake et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
INVENTOR(S)	David A. Haake (Culvert City, California); Colin Halford (Los Angeles, California); Jane T. Babbitt (Culver City, California); Bernard M. Churchill (Pacific Palisades, California)
ABSTRACT	Described are probes and methods for detecting antibiotic susceptibility of a specimen. The method comprises contacting the specimen with an oligonucleotide probe that specifically hybridizes with a target nucleic acid sequence region of ribosomal RNA. The target sequence is at the junction between a pre-ribosomal RNA tail and mature ribosomal RNA of 23S or 16S rRNA. Performing the method in the presence and absence of an antibiotic permits detection of antibiotic susceptibility.
FILED	Friday, May 03, 2013
APPL NO	14/398725
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/106 (20130101)
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10371642 — Raman topography system and methods of imaging

US 10371642	Zavaleta et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)
INVENTOR(S)	Cristina Zavaleta (Los Angeles, California); Michael J. Mandella (Palo Alto, California); Zhen Qiu (Okemos, Michigan)
ABSTRACT	The present disclosure describes a Raman topography system, which includes a container with at least one Raman probe positioned within. Also described are methods of imaging which include the Raman topography system.
FILED	Friday, December 08, 2017
APPL NO	15/835582
ART UNIT	2886 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/043 (20130101) A61B 5/15 (20130101) A61B 5/0071 (20130101) A61B 5/0075 (20130101) A61B 5/0084 (20130101) A61B 5/1072 (20130101) A61B 5/150832 (20130101) A61B 2562/0257 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Original (OR) Class G01N 21/658 (20130101) G01N 21/6456 (20130101) G01N 2021/656 (20130101) G01N 2021/6439 (20130101)
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10371702 — Detection and treatment of autoimmune disorders

US 10371702	Mozaffarian et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Seattle Children's Hospital (Seattle, Washington)
ASSIGNEE(S)	SEATTLE CHILDREN'S HOSPITAL (Seattle, Washington)
INVENTOR(S)	Neelufar Mozaffarian (Mercer Island, Washington); Anne M. Stevens (Seattle, Washington)
ABSTRACT	Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.
FILED	Monday, October 05, 2015
APPL NO	14/874851
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 38/06 (20130101) A61K 38/06 (20130101) A61K 38/07 (20130101) A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 16/2803 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 2333/70503 (20130101) G01N 2800/56 (20130101) G01N 2800/102 (20130101) G01N 2800/104 (20130101)
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10371703 — Antibodies that inhibit long interspersed element-1 retrotransposon endonuclease activity

US 10371703	Belancio et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Victoria Perepelitsa Belancio (New Orleans, Louisiana); Mark Sokolowski (New Orleans, Louisiana)
ASSIGNEE(S)
INVENTOR(S)	Victoria Perepelitsa Belancio (New Orleans, Louisiana); Mark Sokolowski (New Orleans, Louisiana)
ABSTRACT	The present disclosure relates to monoclonal anti-LINE-1 ORF2 protein endonuclease domain antibody, and fragments and derivatives that bind the LINE-1 ORF2 protein endonuclease domain and inhibit its activity.
FILED	Tuesday, November 17, 2015
APPL NO	14/943942
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/40 (20130101) C07K 2317/33 (20130101) C07K 2317/76 (20130101) Enzymes C12Y 301/21 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 33/6863 (20130101) G01N 2333/922 (20130101)
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10371705 — Atomic description of immune complex that causes heparin-induced thrombocytopenia

US 10371705	Greene et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philidelphia, Pennsylvania)
INVENTOR(S)	Mark I. Greene (Penn Valley, Pennsylvania); Douglas B. Cines (Wynnewood, Pennsylvania); Zheng Cai (Wynnewood, Pennsylvania); Zhiqiang Zhu (Philadelphia, Pennsylvania)
ABSTRACT	The present invention provides a humanized antibody or antibody fragment comprising (a) a humanized light chain comprising 1) Complementarity Determining Region (CDR)-L1, the sequence of which is identical to the sequence of SEQ ID NO: 3; 2) CDR-L2, the sequence of which is identical to the sequence of SEQ ID NO: 4; and 3) CDR-L3, the sequence of which is identical to the sequence of SEQ ID NO: 5, and (b) a humanized heavy chain comprising 1) CDR-H1, the sequence of which is identical to the sequence of SEQ ID NO: 6; 2) CDR-H2, the sequence of which is identical to the sequence of SEQ ID NO: 7; and 3) CDR-H3, the sequence of which is identical to the sequence of SEQ ID NO: 8, as well as methods for treating, diagnosing, and monitoring the progression of HIT. The present invention also provides methods for assessing the antigenicity and ability to cause HIT of anionic anticoagulants. The present invention also provides a mutant protein which has the same amino acid sequence of a wild type PF4 monomer except that (i) at least one amino acid of the wild type PF4 monomer has been deleted, (ii) at least one amino acid of the wild type PF4 monomer has been replaced by another amino acid, or (iii) a combination of such changes has been made. The present invention also provides methods of treating or reducing the likelihood of HIT, treating angiogenesis, treating abnormal cell growth, or affecting coagulation pathologies that lead to thrombus formation, by administering such mutant proteins to a patient.
FILED	Thursday, November 05, 2015
APPL NO	15/524511
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/195 (20130101) A61K 39/3955 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/522 (20130101) C07K 16/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) G01N 33/6863 (20130101) Original (OR) Class G01N 2333/522 (20130101) G01N 2400/40 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/222 (20130101)
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10371776 — Optogenetic magnetic resonance imaging

US 10371776	Deisseroth et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Karl Deisseroth (Stanford, California); Jin Hyung Lee (Stanford, California)
ABSTRACT	Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules. Using a light pulse, the light-responsive molecules in the target neural cell population are stimulated. Multiple regions of the brain are scanned via magnetic resonance imaging. The scans allow for observation of a neural reaction in response to the stimulation in at least one of the multiple regions of the brain.
FILED	Friday, May 18, 2018
APPL NO	15/984115
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/4848 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0622 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) Original (OR) Class G01R 33/4808 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 30/40 (20180101)
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10371780 — System and method for post-exposure dosimetry using electron paramagnetic resonance spectroscopy of teeth

US 10371780	Petryakov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
ASSIGNEE(S)	THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
INVENTOR(S)	Sergey V. Petryakov (Lebanon, New Hampshire); Wilson A. Schreiber (Hanover, New Hampshire); Harold M. Swartz (Lyme, New Hampshire); Benjamin B. Williams (Thetford Ctr., Vermont)
ABSTRACT	An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of teeth. When operating in vivo, radiation induced spectra are obtained from intact teeth placed within a magnetic field and with a resonator having a loop and two capacitors formed in metal layers on a printed circuit substrate and located near teeth. The resonator is magnetically coupled to an RF measuring system. The spectra are used to determine radiation dose of a subject. The characteristics of the method and the apparatus make it feasible to utilize the system to measure radiation dose using previously untrained operators working in the field under emergency conditions.
FILED	Monday, June 20, 2016
APPL NO	15/187389
ART UNIT	2868 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4547 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/60 (20130101) Original (OR) Class G01R 33/341 (20130101) G01R 33/3628 (20130101) G01R 33/3642 (20130101) G01R 33/3685 (20130101) G01R 33/3802 (20130101) G01R 33/34007 (20130101)
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10373314 — Systems and methods for diagnosing tumors in a subject by performing a quantitative analysis of texture-based features of a tumor object in a radiological image

US 10373314	Gillies et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida)
ASSIGNEE(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida)
INVENTOR(S)	Robert J. Gillies (Tampa, Florida); Lawrence O. Hall (Tampa, Florida); Dmitry B. Goldgof (Lutz, Florida)
ABSTRACT	An example method for diagnosing tumors in a subject by performing a quantitative analysis of a radiological image can include identifying a region of interest (ROI) in the radiological image, segmenting the ROI from the radiological image, identifying a tumor object in the segmented ROI and segmenting the tumor object from the segmented ROI. The method can also include extracting a plurality of quantitative features describing the segmented tumor object, and classifying the tumor object based on the extracted quantitative features. The quantitative features can include one or more texture-based features.
FILED	Wednesday, February 28, 2018
APPL NO	15/907509
ART UNIT	2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 6/03 (20130101) A61B 6/032 (20130101) A61B 6/037 (20130101) A61B 6/50 (20130101) A61B 6/469 (20130101) A61B 6/5217 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/41 (20170101) G06T 2207/10081 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101)
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10373815 — Methods of resolving artifacts in Hadamard-transformed data

US 10373815	Crowell et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Kevin L. Crowell (Richland, Washington); Spencer A. Prost (Richland, Washington)
ABSTRACT	A method of validating data produced from a multiplexing process on an analytical instrument is disclosed. In one embodiment, the method includes using a pseudorandom sequence to encode a multiplexed segment of data; applying Hadamard transform to generate a demultiplexed segment of the data; aligning the pseudorandom sequence to the multiplexed data; and calculating a score for at least one positive value in the demultiplexed segment to find a valid demultiplexed value.
FILED	Wednesday, March 05, 2014
APPL NO	14/197930
ART UNIT	2864 — Printing/Measuring and Testing
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/0036 (20130101) Original (OR) Class
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10374376 — Divided pulse nonlinear optical sources

US 10374376	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	The Penn State Research Foundation (University Park, Pennsylvania); Atoptix, Inc. (State College, Pennsylvania)
INVENTOR(S)	Zhiwen Liu (State College, Pennsylvania); Victor Bucklew (State College, Pennsylvania); Perry Edwards (State College, Pennsylvania); Chenji Zhang (State College, Pennsylvania)
ABSTRACT	A divided pulse nonlinear optical source may be generated by combining nonlinear wave generation techniques with pulse division that can divide a parent pulse into N divided pulses, each divided pulse separate temporally. The N divided pulses can be passed into a nonlinear optical medium to generate an output. The output can include at least one output pulse for each divided pulse. The center wavelengths of each output pulse can be tuned so that each may have a center wavelength that is the same as, or differs from, each other output pulse. In some embodiments, the output pulses may be combined to generate the output. The output can be power scalable and wavelength tunable.
FILED	Wednesday, May 16, 2018
APPL NO	15/980839
ART UNIT	2637 — Optical Communications
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) G01J 3/42 (20130101) G01J 3/44 (20130101) G01J 3/0205 (20130101) G01J 3/0218 (20130101) G01J 3/0224 (20130101) G01J 3/0237 (20130101) G01J 3/0245 (20130101) G01J 2003/1282 (20130101) Optical Elements, Systems, or Apparatus G02B 27/10 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/39 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/005 (20130101) H01S 3/0057 (20130101) H01S 3/0071 (20130101) Original (OR) Class H01S 3/0092 (20130101) H01S 2301/08 (20130101) Multiplex Communication H04J 14/02 (20130101)
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Department of Defense (DOD)

10368792 — Method for detecting deception and predicting interviewer accuracy in investigative interviewing using interviewer, interviewee and dyadic physiological and behavioral measurements

US 10368792	Keshava et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)	THE CHARLES STARK DRAPER LABORATORY INC. (Cambridge, Massachusetts)
INVENTOR(S)	Nirmal Keshava (Needham, Massachusetts); Andrea K. Webb (Medford, Massachusetts); Laura J. Mariano (Belmont, Massachusetts); Philip D. Parks (Jamaica Plain, Massachusetts); Joshua C. Poore (Cambridge, Massachusetts)
ABSTRACT	Existing approaches for deception detection are primarily based on polygraph systems that measure specific channels of physiology in highly structured interviews and that are interpreted by trained polygraph examiners. Existing approaches for predicting interviewer accuracy involve interviewers' own estimates of their performances which inevitably are biased. The methods and systems described herein provides objective, quantitative and automated metrics to detect deception and predict interviewer accuracy. Physiological information of the interviewer during the interview is recorded by at least a first sensor. The physiological information includes a time series of physiological data. An interview assessment is calculated by a computer. By processing the recorded physiological information, the interview assessment indicates at least one of whether a statement made by the interviewee is likely to be deceitful and whether the interviewer is likely to be accurate in estimating truthfulness of the interviewee. The interview assessment is output by the computer.
FILED	Tuesday, June 02, 2015
APPL NO	14/728527
ART UNIT	3715 — Amusement and Education Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/11 (20130101) A61B 5/0077 (20130101) A61B 5/164 (20130101) Original (OR) Class A61B 5/0205 (20130101) A61B 5/0402 (20130101) A61B 5/0404 (20130101) A61B 5/0533 (20130101) A61B 5/0816 (20130101) A61B 5/1128 (20130101) A61B 5/6823 (20130101) A61B 5/6824 (20130101) A61B 5/6828 (20130101) A61B 5/6829 (20130101) A61B 5/14551 (20130101) A61B 5/14552 (20130101)
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10368847 — Devices for integrated, repeated, prolonged, and/or reliable sweat stimulation and biosensing

US 10368847	Heikenfeld et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	University Of Cincinnati (Cincinnati, Ohio)
ASSIGNEE(S)	University of Cincinnati (Cincinnati, Ohio)
INVENTOR(S)	Jason Charles Heikenfeld (Cincinnati, Ohio); Zachary Cole Sonner (Elsmere, Kentucky)
ABSTRACT	A sweat sensing device includes a plurality of sweat collection pads communicating with a sensor. Each of the pads is activated by a timing circuit which allows one or more of the pads to be activated at a selected time and subsequent deactivated after a defined period of time. This allows for selective collection of sweat from a plurality of pads over a prolonged period of time. An impedance measuring circuit can be employed to determine if one or more of the pads becomes disconnected, in order to avoid irritation. Further, the devices can use a common microfluidic device which both transports sweat activating substance, such as pilocarpine, to the surface of the skin and directs sweat away from the skin to a sensing device.
FILED	Thursday, March 29, 2018
APPL NO	15/939429
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0531 (20130101) A61B 5/0537 (20130101) A61B 5/1491 (20130101) A61B 5/04085 (20130101) A61B 5/4266 (20130101) A61B 5/6843 (20130101) A61B 5/14521 (20130101) A61B 10/0064 (20130101) Original (OR) Class A61B 2010/0009 (20130101) A61B 2562/168 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2202/092 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/325 (20130101)
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10368872 — System and method for low profile occlusion balloon catheter

US 10368872	Franklin et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA)
APPLICANT(S)	Prytime Medical Devices, Inc. (Boerne, Texas)
ASSIGNEE(S)	Prytime Medical Devices, Inc. (Boerne, Texas)
INVENTOR(S)	Curtis J. Franklin (Lakewood, Colorado); Todd J. Krummenacher (Lakewood, Colorado); Jeremy Reynolds (Lakewood, Colorado); David Spencer (Boerne, Texas); Luke William Fisher (Lakewood, Colorado)
ABSTRACT	An occlusion catheter system includes an inflation catheter member and an occlusion balloon. The proximal and distal balloon ends are connected to the inflation catheter between the proximal and distal catheter ends. A distal pressure sensor is attached to the inflation catheter member between the proximal balloon end and the atraumatic tip. An inflatable spine is connected to the inflation catheter. The proximal spine end is connected to the inflation catheter near the proximal balloon end and the distal spine end is connected to the inflation catheter near the distal balloon end. The occlusion balloon and the inflatable spine are configured to define blood flow channels with the internal surface and the external balloon surface when the occlusion catheter system is at least partially positioned in the vessel and the occlusion balloon and the inflatable spine are in a partially inflated configuration.
FILED	Friday, June 02, 2017
APPL NO	15/573054
ART UNIT	3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/12036 (20130101) A61B 17/12109 (20130101) A61B 17/12136 (20130101) Original (OR) Class A61B 2017/22051 (20130101) A61B 2017/22055 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/00 (20130101) A61M 25/02 (20130101) A61M 25/10 (20130101) A61M 25/0068 (20130101) A61M 25/104 (20130101) A61M 25/1002 (20130101) A61M 25/1011 (20130101) A61M 25/10184 (20131105) A61M 2025/0002 (20130101) A61M 2025/0003 (20130101) A61M 2025/024 (20130101) A61M 2025/028 (20130101) A61M 2025/0286 (20130101) A61M 2025/1052 (20130101) A61M 2025/1056 (20130101) A61M 2025/1061 (20130101) A61M 2025/1084 (20130101) A61M 2025/1088 (20130101) A61M 2025/1095 (20130101)
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10368993 — Shape-memory-actuated materials for accelerated healing of orthopedic injuries

US 10368993	Henderson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	James Henderson (Syracuse, New York); Patrick T. Mather (Oxford, Pennsylvania)
ASSIGNEE(S)	Syracuse University (Syracuse, New York)
INVENTOR(S)	James Henderson (Syracuse, New York); Patrick T. Mather (Oxford, Pennsylvania)
ABSTRACT	A three component system for repairing critically sized bone defects having a first shape memory polymer (SMP) component formed as a scaffold that fills the defects, a second SMP component formed as a restricting sleeve that stabilizes and supports osseointegration and osteoconduction, and a third SMP component formed as a two-dimensional cell culture substrate for engineering periosteal grafts.
FILED	Thursday, July 13, 2017
APPL NO	15/648721
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/28 (20130101) A61F 2/2846 (20130101) Original (OR) Class A61F 2002/285 (20130101) A61F 2002/2817 (20130101) A61F 2002/2839 (20130101) A61F 2002/30092 (20130101) A61F 2210/0014 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/14 (20130101) A61L 27/16 (20130101) A61L 27/18 (20130101) A61L 27/50 (20130101) A61L 27/56 (20130101) A61L 27/3847 (20130101) A61L 2400/16 (20130101) A61L 2430/02 (20130101)
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10369016 — Modular and lightweight myoelectric prosthesis components and related methods

US 10369016	Lipsey et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	REHABILITATION INSTITUTE OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)	Rehabilitation Institute of Chicago (Chicago, Illinois)
INVENTOR(S)	James Lipsey (Oak Park, Illinois); Jon Sensinger (Fredericton, Canada)
ABSTRACT	Prosthetic devices and, more particularly, modular myoelectric prosthesis components and related methods, are described. In one embodiment, a hand for a prosthetic limb may comprise a rotor-motor; a transmission, comprising a differential roller screw; a linkage coupled to the transmission; and at least one finger coupled to the linkage. In one embodiment, a component part of a wrist of a prosthetic limb may comprise an exterior-rotor motor, a planetary gear transmission, a clutch, and a cycloid transmission. In one embodiment, an elbow for a prosthetic limb may comprise an exterior-rotor motor, and a transmission comprising a planetary gear transmission, a non-backdrivable clutch, and a screw.
FILED	Tuesday, November 07, 2017
APPL NO	15/806209
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/68 (20130101) A61F 2/72 (20130101) A61F 2/582 (20130101) Original (OR) Class A61F 2/583 (20130101) A61F 2/585 (20130101) A61F 2/586 (20130101) A61F 2002/543 (20130101) A61F 2002/587 (20130101) A61F 2002/701 (20130101) A61F 2002/704 (20130101) A61F 2002/5043 (20130101) A61F 2002/5072 (20130101) A61F 2002/6836 (20130101) A61F 2002/6845 (20130101) A61F 2002/6872 (20130101) A61F 2310/00047 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 15/0009 (20130101) B25J 15/086 (20130101) B25J 17/0258 (20130101) Couplings for Transmitting Rotation; Clutches; Brakes F16D 15/00 (20130101) Gearing F16H 25/2252 (20130101) F16H 37/041 (20130101) F16H 2035/005 (20130101) Dynamo-electric Machines H02K 7/14 (20130101) H02K 7/116 (20130101)
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10369022 — System for control of a prosthetic device

US 10369022	van der Merwe et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Research, Development and Engineering Command (RDECOM)
APPLICANT(S)	DEKA Products Limited Partnership (Manchester, New Hampshire)
ASSIGNEE(S)	DEKA PRODUCTS LIMITED PARTNERSHIP (Manchester, New Hampshire)
INVENTOR(S)	Dirk Albertus van der Merwe (Canterbury, New Hampshire); Gregory R. Lanier (Manchester, New Hampshire); John M. Kerwin (Manchester, New Hampshire); Gerald M. Guay (Greenville, New Hampshire); N. Christopher Perry (Manchester, New Hampshire); Susan D. Dastous (Litchfield, New Hampshire)
ABSTRACT	A control system for control of a prosthetic device having a plurality of actuators receives an orientation signal indicative of a desired movement. The control system evaluates whether the prosthetic device may move as desired with a current angle of rotation and commands at least one actuator to move the prosthetic device as desired by maintaining the current angle of rotation or by adjusting the angle of rotation if the prosthetic device cannot move as desired with the current angle. The control system may alternate between commanding a first subset of actuators and a second subset of actuators each time the orientation signal is indicative of a neutral position. The control system may include a position sensor and a compliance sensor and may command at least one actuator based on a combination of positional control using the position sensor and force control using the compliance sensor.
FILED	Monday, August 24, 2015
APPL NO	14/833781
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0488 (20130101) A61B 5/1036 (20130101) A61B 5/4528 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/54 (20130101) A61F 2/68 (20130101) Original (OR) Class A61F 2/72 (20130101) A61F 2/582 (20130101) A61F 2/583 (20130101) A61F 2/585 (20130101) A61F 2/586 (20130101) A61F 2002/543 (20130101) A61F 2002/546 (20130101) A61F 2002/587 (20130101) A61F 2002/701 (20130101) A61F 2002/704 (20130101) A61F 2002/705 (20130101) A61F 2002/707 (20130101) A61F 2002/762 (20130101) A61F 2002/764 (20130101) A61F 2002/5018 (20130101) A61F 2002/5021 (20130101) A61F 2002/6827 (20130101) A61F 2002/7625 (20130101) A61F 2002/7635 (20130101) A61F 2002/7645 (20130101) A61F 2002/7685 (20130101)
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10369023 — Impedance parameter power control for lower limb assistive device

US 10369023	Simon et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	REHABILITATION INSTITUTE OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)	Rehabilitation Institute of Chicago (Chicago, Illinois)
INVENTOR(S)	Ann M. Simon (Chicago, Illinois); Nicholas P. Fey (Chicago, Illinois)
ABSTRACT	Systems and methods are described that relate to the control of a powered lower limb assistive device with one or more joints, where a controller of the assistive device is configured to receive one or more user-generated signals, determine control information using information in the one or more user-generated signals, select one or more joint impedance parameters of the assistive device for adjustment, and, for a mode and state of the assistive device, adjust the selected joint impedance parameters as a function of the control information. Additionally, systems and methods are described that relate to the control of such an assistive device, where a controller of the assistive device is configured to receive one or more user-generated signals containing information about the ankle angle of the assistive device, and adjust the stiffness of the ankle joint of the assistive device as a function of the ankle angle.
FILED	Friday, November 01, 2013
APPL NO	14/070150
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) A61F 2/64 (20130101) A61F 2/68 (20130101) A61F 2/72 (20130101) Original (OR) Class A61F 2/6607 (20130101) A61F 2002/503 (20130101) A61F 2002/607 (20130101) A61F 2002/701 (20130101) A61F 2002/704 (20130101) A61F 2002/5033 (20130101) A61F 2002/7625 (20130101) A61F 2002/7635 (20130101)
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10369248 — Porous polymer composites

US 10369248	Mrozek et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Randy A. Mrozek (Baltimore, Maryland); Joseph L. Lenhart (Port Deposit, Maryland); Michael C. Berg (Baltimore, Maryland); Eric J. Robinette (Wilmington, Delaware)
ABSTRACT	Porous polymer composites and methods of preparing porous polymer composites are provided herein. In some embodiments, a method for preparing porous polymer composites may include mixing a first polymer with a solvent and a particulate filler to form a first polymer composition, wherein the amount of particulate filler in the first polymer composition is below a mechanical percolation threshold; and removing the solvent from the first polymer composition to concentrate the first polymer and particulate filler into a second polymer composition having a porous structure, wherein the particulate filler concentration in the second polymer composition is increased above the mechanical percolation threshold during solvent removal.
FILED	Tuesday, July 29, 2014
APPL NO	14/445089
ART UNIT	1619 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/0015 (20130101) A61L 24/0036 (20130101) Original (OR) Class A61L 2300/418 (20130101) A61L 2400/04 (20130101) A61L 2400/08 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/26 (20130101) C08J 9/28 (20130101) C08J 2201/0543 (20130101) C08J 2207/10 (20130101) C08J 2207/12 (20130101) C08J 2353/02 (20130101)
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10369249 — In situ solidifying complex coacervates and methods of making and using thereof

US 10369249	Stewart
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S)	University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Russell J. Stewart (Salt Lake City, Utah)
ABSTRACT	Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.
FILED	Friday, January 26, 2018
APPL NO	15/880650
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0043 (20130101) A61K 49/0054 (20130101) A61K 49/0073 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/02 (20130101) A61L 24/10 (20130101) A61L 24/0015 (20130101) A61L 24/0031 (20130101) A61L 24/0042 (20130101) A61L 24/043 (20130101) A61L 24/043 (20130101) A61L 24/046 (20130101) Original (OR) Class A61L 24/104 (20130101) A61L 2300/44 (20130101) A61L 2300/416 (20130101) A61L 2430/02 (20130101) A61L 2430/36 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1668 (20130101)
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10369351 — Electrode interfaces and electrode assemblies for performing transcranial direct current stimulation

US 10369351	Weisend et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Michael P. Weisend (Yellow Springs, Ohio); Matthew S. Sherwood (Sidney, Ohio); Megan K. Howes (Venice, Florida)
ASSIGNEE(S)	Wright State University (Dayton, Ohio)
INVENTOR(S)	Michael P. Weisend (Yellow Springs, Ohio); Matthew S. Sherwood (Sidney, Ohio); Megan K. Howes (Venice, Florida)
ABSTRACT	Electrode interfaces and electrode assemblies for performing transcranial direct current stimulation. The electrode interfaces include a body configured to be coupled to an electrode for delivery of electrical current therethrough. The body includes a non-contact surface and a contact surface opposing the non-contact surface. The body defines a plurality of conductivity passages extending therethrough from the non-contact surface to the contact surface. Each conductivity passage is disposed along a central axis and includes at least one branching inlet and at least one branching subpassage extending from the at least one branching inlet to the contact surface. Each branching subpassage defines a plurality of branches, and each branch diverges from the central axis and then extends to the contact surface. The electrode assemblies include a neurostimulation device, at least two electrodes coupled to the neurostimulation device, and an electrode interface including a body coupled to each electrode.
FILED	Monday, October 16, 2017
APPL NO	15/784697
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/20 (20130101) A61N 1/0456 (20130101) Original (OR) Class A61N 1/0476 (20130101) A61N 1/36025 (20130101)
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10370072 — Laser mounting fixture

US 10370072	Grate et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Ryan Grate (Oxnard, California); Javier Esparza (Oxnard, California)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Ryan Grate (Oxnard, California); Javier Esparza (Oxnard, California)
ABSTRACT	A fixture for mounting a laser to an extended edge, such as ship bulkhead, so that precision measurements can be made at close ranges, including over-the side situations. The fixture has a set of attached mounting plates, the first of which includes a ring assembly on which multiple types of lasers can be mounted. The fixture also has a plate with a hook and clamping mechanism to secure the fixture to the extended edge. Gussets connect the plates at an angle that helps creates a wide range of sight for the laser, as well as a secure rotational pivot point to assist with laser mounting after the fixture is attached to an edge. This fixture allows the laser operator to forgo tripods and similar fixtures which, at ground level and close quarters, allow only a limited field of view, as well as elevated, over the side situations, which are awkward and unsafe for set up and adjustment.
FILED	Monday, July 17, 2017
APPL NO	15/651663
ART UNIT	3632 — Static Structures, Supports and Furniture
CURRENT CPC	Ships or Other Waterborne Vessels; Equipment for Shipping B63B 49/00 (20130101) Original (OR) Class Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/022 (20130101) Functional Features or Details of Lighting Devices or Systems Thereof; Structural Combinations of Lighting Devices With Other Articles, Not Otherwise Provided for F21V 17/12 (20130101) F21V 21/088 (20130101)
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10370092 — Vehicle load-limiting suspension apparatus and control methods therefor

US 10370092	Bolukbasi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Akif O. Bolukbasi (Mesa, Arizona); Timothy R. Gleason (Mesa, Arizona)
ABSTRACT	A vehicle load-limiting suspension apparatus comprises at least one shear tab for controlling an amount of impact load applied to a vehicle structure when a vehicle impact event occurs. The vehicle load-limiting suspension apparatus further comprises at least one crush tube for limiting the amount of impact load applied to the vehicle structure after the at least one shear tab shears in response to occurrence of the vehicle impact event.
FILED	Wednesday, August 17, 2016
APPL NO	15/239294
ART UNIT	3669 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 25/58 (20130101) B64C 27/001 (20130101) Original (OR) Class B64C 27/006 (20130101) B64C 2027/002 (20130101) B64C 2027/004 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 11/0619 (20141201) B64D 45/00 (20130101) B64D 2045/0085 (20130101) Springs; Shock-absorbers; Means for Damping Vibration F16F 7/003 (20130101) F16F 7/12 (20130101) F16F 7/125 (20130101) F16F 2230/18 (20130101)
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10370120 — Launcher for an unmanned aircraft and methods of use thereof

US 10370120	McGann et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Shawn Kerry McGann (Ridgecrest, California); Nicholas McGaha (Ridgecrest, California); Alvin L. Quintana (Ridgecrest, California)
ABSTRACT	A launcher for an unmanned aircraft may comprise: a launch rail, a carriage, pair of pulley drivers, and a cable and pulley system. The pulley drivers may produce opposing pulley drive forces, which may be converted into a single launching force via the cable and pulley system for launching the carriage. The cable and pulley system may comprise: launch rail pulleys, pulley block pulleys, cam pulleys, drive cables, and one or more winches. Embodiments of the launcher may apply a constant force to the aircraft uniformly over the launch distance, such that the unmanned aircraft may be propelled within a relatively short distance by applying energy to the aircraft in the smallest period of time and without exceeding the aircraft's acceleration limits.
FILED	Thursday, April 13, 2017
APPL NO	15/486481
ART UNIT	3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/084 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/06 (20130101) Original (OR) Class
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10370121 — Launcher for an unmanned aircraft

US 10370121	McGann et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America as Represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Shawn Kerry McGann (Ridgecrest, California); Nicholas McGaha (Ridgecrest, California); Alvin L. Quintana (Ridgecrest, California)
ABSTRACT	A launcher for an unmanned aircraft may comprise: a launch rail, a carriage, pair of pulley drivers, and a cable and pulley system. The pulley drivers may produce opposing pulley drive forces, which may be converted into a single launching force via the cable and pulley system for launching the carriage. The cable and pulley system may comprise: launch rail pulleys, pulley block pulleys, cam pulleys, drive cables, and one or more winches. Embodiments of the launcher may apply a constant force to the aircraft uniformly over the launch distance, such that the unmanned aircraft may be propelled within a relatively short distance by applying energy to the aircraft in the smallest period of time and without exceeding the aircraft's acceleration limits.
FILED	Thursday, April 13, 2017
APPL NO	15/486988
ART UNIT	3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/084 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/06 (20130101) Original (OR) Class B64F 1/08 (20130101)
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10370245 — Methods and compositions using peptides and proteins with C-terminal elements

US 10370245	Ruoslahti et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Erkki Ruoslahti (Buellton, California); Tambet Teesalu (Goleta, California); Kazuki Sugahara (Goleta, California)
ASSIGNEE(S)	Sanford-Burnham Medical Research Institute (La Jolla, California)
INVENTOR(S)	Erkki Ruoslahti (Buellton, California); Tambet Teesalu (Goleta, California); Kazuki Sugahara (Goleta, California)
ABSTRACT	Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
FILED	Tuesday, June 22, 2010
APPL NO	12/821050
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/66 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Original (OR) Class
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10370280 — Method of making optical fibers with multiple openings

US 10370280	Gibson et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Daniel J. Gibson (Cheverly, Maryland); Rafael R. Gattass (Washington, District of Columbia); Daniel L. Rhonehouse (Chesapeake Beach, Maryland); Shyam S. Bayya (Ashburn, Virginia); L. Brandon Shaw (Woodbridge, Virginia); Jasbinder S. Sanghera (Ashburn, Virginia)
ABSTRACT	A method of making an optical fiber with multiple openings comprising the steps of fabricating an extrusion die using additive manufacturing such that the extrusion die has a plurality of channels that combine inside the die into another set of channels, extruding a glass, forming a fiber optic preform having a plurality of longitudinal openings that run the entire length, attaching a barrier layer for pressure application, and stretching the preform into an optical fiber with multiple openings. An extrusion die comprising an additive manufactured material, having a proximal side having openings and having a distal side having openings, wherein the openings of the proximal side are of feed channels, wherein the openings of the distal side are of forming channels, and wherein in side the body of the die, two of the feed channels combine the forming channels.
FILED	Monday, October 02, 2017
APPL NO	15/722385
ART UNIT	2883 — Optics
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/09 (20190201) B29C 48/11 (20190201) B29C 48/0018 (20190201) B29C 48/30 (20190201) B29C 48/32 (20190201) B29C 48/345 (20190201) B29C 48/3003 (20190201) Manufacture, Shaping, or Supplementary Processes C03B 17/04 (20130101) Original (OR) Class C03B 37/0279 (20130101) C03B 2201/86 (20130101) C03B 2201/88 (20130101) C03B 2203/42 (20130101) Optical Elements, Systems, or Apparatus G02B 6/02042 (20130101)
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10370407 — Affinity-assisted protein modification and recycling

US 10370407	Kwant et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents Of The University Of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Richard L. Kwant (Oakland, California); Matthew B. Francis (Berkeley, California); Christian B. Rosen (Berkeley, California); Meera Rao (San Francisco, California)
ABSTRACT	Methods for preparing a protein conjugate having a defined number of conjugate groups are provided. The method includes: forming a mixture containing a macrocyclic matrix material and a plurality of proteins; eluting the proteins to obtain a first separated protein fraction and a second separated protein fraction, wherein substantially all of the proteins in the first separated protein fraction have the same number of handle moieties; contacting the handle moieties with a conversion reagent under conditions sufficient to convert the handle moieties in the first separated protein fraction to reactive moieties; and contacting the reactive moieties with a conjugation reagent under conditions sufficient to form a plurality of protein conjugates, wherein substantially all of the protein conjugates in the plurality have the same number of conjugate groups. Methods also include recovering enzymes and other proteins from mixtures for isolation and/or reuse of the enzymes and proteins.
FILED	Thursday, January 21, 2016
APPL NO	15/545459
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 1/13 (20130101) C07K 1/1077 (20130101) Original (OR) Class Polysaccharides; Derivatives Thereof C08B 37/0012 (20130101) C08B 37/0015 (20130101) Derivatives of Natural Macromolecular Compounds C08H 1/00 (20130101)
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10370440 — Reconstituted polypeptides

US 10370440	Koide
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Research CorporationTechnologies, Inc. (Tucson, Arizona)
ASSIGNEE(S)	Research Corporation Technologies, Inc. (Tuscon, Arizona)
INVENTOR(S)	Shohei Koide (Chicago, Illinois)
ABSTRACT	The present invention provides modified fibronectin type III (Fn3) molecules, and nucleic acid molecules encoding the modified Fn3 molecules. Also provided are methods of preparing these molecules, and kits to perform the methods.
FILED	Thursday, April 30, 2015
APPL NO	14/701331
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/78 (20130101) C07K 16/00 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/565 (20130101) C07K 2318/20 (20130101)
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10370477 — Broad wavelength range chemically tunable photonic materials

US 10370477	Kang et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Youngjong Kang (Kyounggi-Do, South Korea); Joseph Walish (Cambridge, Massachusetts); Edwin L. Thomas (Houston, Texas)
ABSTRACT	The present invention provides polymeric materials arranged as photonic crystals, or portions of photonic crystals, having properties which can be easily tuned over a large range of wavelengths upon exposure to an external stimulus. In some embodiments, the photonic crystals comprise at least one portion which can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus, resulting in a change in a diffracted wavelength of electromagnetic radiation (e.g, light) by the photonic crystal. Embodiments of the invention may advantageously exhibit large stop band tunability and rapid response times. Photonic crystals of the invention may be useful in a wide variety of applications, such as colorimetric sensors, active components of simple display devices, electrically controlled tunable optically pumped laser, photonic switches, multiband filters, and the like.
FILED	Monday, May 09, 2016
APPL NO	15/150320
ART UNIT	1763 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 293/00 (20130101) Original (OR) Class Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/12 (20130101) Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) G02B 5/20 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/15 (20130101) G02F 1/061 (20130101) G02F 1/0121 (20130101) G02F 1/0147 (20130101) G02F 2001/164 (20190101) G02F 2202/022 (20130101) G02F 2202/32 (20130101) G02F 2202/36 (20130101) G02F 2203/023 (20130101)
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10370543 — High quality antimicrobial paint composition

US 10370543	Gisser et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	THE SHERWIN-WILLIAMS COMPANY (Cleveland, Ohio)
ASSIGNEE(S)	The Sherwin-Williams Company (Cleveland, Ohio)
INVENTOR(S)	Kathleen R Gisser (Solon, Ohio); Morgan S Sibbald (Copley, Ohio); Wanda J Smith (Macedonia, Ohio); Janice K. Dreshar (Westlake, Ohio); Donald A. Prochazka (Strongsville, Ohio)
ABSTRACT	A high quality paint formulation comprises water, latex polymer, pigment, and a quaternary ammonium compound. The high quality paint is capable of killing gram positive bacteria, gram negative bacteria at a rate of greater than 3 logs within 2 hours of application of bacteria to a painted surface. The high quality paint is also capable of inactivating viruses.
FILED	Wednesday, March 16, 2016
APPL NO	15/071385
ART UNIT	1768 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) A01N 25/28 (20130101) A01N 33/12 (20130101) A01N 33/12 (20130101) A01N 59/16 (20130101) A01N 2300/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/17 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) Original (OR) Class C09D 5/1625 (20130101) C09D 7/69 (20180101)
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10370544 — High quality biocidal paint

US 10370544	Gisser et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	THE SHERWIN-WILLIAMS COMPANY (Cleveland, Ohio)
ASSIGNEE(S)	THE SHERWIN-WILLIAMS COMPANY (Cleveland, Ohio)
INVENTOR(S)	Kathleen R Gisser (Solon, Ohio); Morgan S Sibbald (Copley, Ohio); Wanda J Smith (Macedonia, Ohio); Janice K. Dreshar (Westlake, Ohio); Donald A. Prochazka (Strongsville, Ohio); Tony A. Rook (Lakewood, Ohio)
ABSTRACT	A high quality paint comprises water, latex polymer, pigment, and biocidal agent. The coating provided by the high quality paint may be capable of killing gram positive bacteria, gram negative bacteria at a rate of greater than 3 logs within 2 hours of application of bacteria to a painted surface. The coating provided by the high quality of paint may be capable of continuing to kill gram positive bacteria, gram negative bacteria at a rate of greater than 1 log within 2 hours even after repeated contamination of the surface. The coating provided by the high quality paint may be capable of delivering residual killing of gram positive bacteria, gram negative bacteria for up to 48 months. The coating provided by the high quality paint may also be capable of inactivating viruses.
FILED	Tuesday, July 05, 2016
APPL NO	15/201658
ART UNIT	1768 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) A01N 25/04 (20130101) A01N 25/10 (20130101) A01N 25/10 (20130101) A01N 33/12 (20130101) A01N 33/12 (20130101) A01N 43/40 (20130101) A01N 43/40 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/14 (20130101) A61K 31/4425 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/17 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) C09D 5/1625 (20130101) Original (OR) Class C09D 133/08 (20130101) Technologies for Adaptation to Climate Change Y02A 50/473 (20180101)
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10370661 — Nucleic acid functionalized nanoparticles for therapeutic applications

US 10370661	Mirkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); Nathaniel L. Rosi (Chicago, Illinois); C. Shad Thaxton (Chicago, Illinois); David A. Giljohann (Chicago, Illinois)
ABSTRACT	Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.
FILED	Wednesday, July 19, 2017
APPL NO	15/654401
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/5115 (20130101) A61K 31/7088 (20130101) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/314 (20130101) C12N 2310/315 (20130101) C12N 2310/351 (20130101) C12N 2310/3181 (20130101) C12N 2320/32 (20130101)
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10370717 — Methods for the measurement of post-traumatic stress disorder microRNA markers

US 10370717	Maheshwari et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
APPLICANT(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S)	Radha K. Maheshwari (Rockville, Maryland); Nagaraja S. Balakathiresan (Clarksburg, Maryland); Manish Bhomia (Rockville, Maryland); Raghavendar Chandran (Rockville, Maryland)
ABSTRACT	The present invention provides for methods of measuring levels of micro RNAs for the diagnosis, treatment and/or monitoring the progression of post-traumatic stress disorder (PTSD) or traumatic brain injury (TBI) in a subject having or suspected of having PTSD and/or TBI. The methods, in general comprise measuring levels of at least one of miR-142-5p, miR-19b, miR-1928, miR-223-3p, miR-322, miR-324, miR-421-3p, miR-463 and miR-674* is a sample from a subject suffering from or suspected of having PTSD and/or TBI.
FILED	Tuesday, April 21, 2015
APPL NO	15/306178
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) C12Q 2600/178 (20130101)
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10370980 — Lost core structural frame

US 10370980	Taffet et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Department of the Navy (DON) Naval Air Systems Command (NAVAIR)
APPLICANT(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
ASSIGNEE(S)	United Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Steven Taffet (South Windsor, Connecticut); Brandon S. Donnell (Hartford, Connecticut); Daniel C. Nadeau (Wethersfield, Connecticut); Russell Deibel (Glastonbury, Connecticut); San Quach (East Hartford, Connecticut)
ABSTRACT	A lost core mold component comprises a first leg and a second leg with a plurality of crossover members connecting the first and second legs. The plurality of crossover members includes outermost crossover members spaced from each other. Adjacent ends of each of the first and second legs, and second crossover members are spaced closer to each other than are the outermost crossover members. Central crossover members extend between the first and second leg and between the second crossover members. The outermost crossover members extend for a first cross-sectional area. The second crossover members extend for a second cross-sectional area and the central crossover members extend for a third cross-sectional area. The first cross-sectional area is greater than the second cross-sectional area. The second cross-sectional area is greater than the third cross-sectional area. A gas turbine engine and component are also disclosed.
FILED	Thursday, November 20, 2014
APPL NO	15/039918
ART UNIT	1744 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Foundry Moulding B22C 7/02 (20130101) B22C 9/04 (20130101) B22C 9/10 (20130101) B22C 9/24 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/187 (20130101) Original (OR) Class F01D 9/041 (20130101) F01D 25/12 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2230/21 (20130101) F05D 2230/211 (20130101) F05D 2240/121 (20130101) F05D 2240/122 (20130101) F05D 2240/303 (20130101) F05D 2240/304 (20130101) F05D 2260/202 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/676 (20130101)
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10370995 — Gas turbine engine vane end devices

US 10370995	Taketa et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana)
ASSIGNEE(S)	Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana)
INVENTOR(S)	Linnea Taketa (Indianapolis, Indiana); John Munson (Indianapolis, Indiana); Ted J. Freeman (Danville, Indiana)
ABSTRACT	A turbomachinery component of a gas turbine engine is disclosed having a number of techniques of reducing the effects of a gap flow between an airfoil member of the gas turbine engine and a wall of the gas turbine engine. The airfoil member can be variable and in one form is a variable turbine vane. In one embodiment a brush seal is included between the vane and the wall. In another form a wear surface is disposed between the vane and the wall. In yet another form a moveable member capable of being actuated to change position can be disposed between the vane and the wall to alter the size of a gap between the two.
FILED	Tuesday, November 28, 2017
APPL NO	15/824467
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/28 (20130101) F01D 9/041 (20130101) F01D 11/00 (20130101) F01D 11/02 (20130101) F01D 11/005 (20130101) Original (OR) Class F01D 11/025 (20130101) F01D 11/122 (20130101) F01D 17/148 (20130101) F01D 17/162 (20130101) F01D 17/165 (20130101) Non-positive-displacement Pumps F04D 19/02 (20130101) F04D 27/002 (20130101) F04D 27/0246 (20130101) F04D 29/083 (20130101) F04D 29/164 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/571 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/56 (20130101) Pistons; Cylinders; Sealings F16J 15/3288 (20130101)
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10370996 — Floating, non-contact seal with offset build clearance for load imbalance

US 10370996	Wilson et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	United Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Ross Wilson (South Glastonbury, Connecticut); Conway Chuong (Manchester, Connecticut); Dwayne K. Mecklenburg (Stafford Springs, Connecticut)
ABSTRACT	Aspects of the disclosure are directed to an engine comprising: a first structure, a second structure configured to rotate relative to the first structure, and a floating, non-contact seal that interfaces the first structure and the second structure, where the seal includes: a shoe, a first beam coupled to the shoe, and a second beam coupled to the shoe, where during a non-operational state of the engine a reference point of the shoe is substantially centered within a range of radial deflections of the reference point of the shoe over the operating range of the engine.
FILED	Tuesday, August 23, 2016
APPL NO	15/244276
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/02 (20130101) F01D 11/025 (20130101) Original (OR) Class F01D 25/24 (20130101) Non-positive-displacement Pumps F04D 29/083 (20130101) F04D 29/102 (20130101) F04D 29/321 (20130101) F04D 29/522 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/60 (20130101) Pistons; Cylinders; Sealings F16J 15/442 (20130101) F16J 15/445 (20130101)
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10370999 — Gas turbine engine rapid response clearance control system with air seal segment interface

US 10370999	Blaney et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	United Technologies Corporation (Hartford, Connecticut)
ASSIGNEE(S)	United Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Ken F. Blaney (Middleton, New Hampshire); Paul M. Lutjen (Kennebunkport, Maine); Brian R. Pelletier (Berwick, Maine)
ABSTRACT	An active clearance control system of a gas turbine engine includes an air seal segment with a bridge hook having a lugged aperture.
FILED	Thursday, February 06, 2014
APPL NO	14/780838
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/20 (20130101) Original (OR) Class F01D 11/22 (20130101) Non-positive-displacement Pumps F04D 29/164 (20130101) F04D 29/526 (20130101)
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10371053 — Microchannel heat exchangers for gas turbine intercooling and condensing

US 10371053	Loebig et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Rolls-Royce Corporation (Indianapolis, Indiana); Rolls-Royce North American Technologies, Inc. (Indianapolis, Indiana)
ASSIGNEE(S)	Rolls-Royce North American Technologies, Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana)
INVENTOR(S)	James C. Loebig (Greenwood, Indiana); Emil R. Dejulio (Columbus, Indiana)
ABSTRACT	A gas turbine engine heat exchange system includes a first microchannel heat exchanger (MCHX) configured to transfer heat between a first air stream and a working fluid. The first MCHX includes a plurality of air-passage layers. Each of the air-passage layers includes a plurality of etched air-passage microchannels that are configured to allow passage of the first air stream therethrough. The first MCHX also includes a plurality of working fluid layers. Each working fluid layer includes a plurality of etched working fluid microchannels that are configured to allow passage of the working fluid therethrough.
FILED	Tuesday, February 17, 2015
APPL NO	14/623707
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) F02C 7/18 (20130101) Original (OR) Class F02C 7/143 (20130101) Jet-propulsion Plants F02K 3/115 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2210/13 (20130101) F05D 2220/62 (20130101) F05D 2220/72 (20130101) F05D 2230/11 (20130101) F05D 2260/204 (20130101) F05D 2260/205 (20130101) F05D 2260/207 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 9/0012 (20130101) F28D 9/0031 (20130101) F28D 9/0037 (20130101) F28D 2021/0026 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 3/048 (20130101) F28F 9/026 (20130101) F28F 2260/00 (20130101) F28F 2275/00 (20130101) F28F 2275/061 (20130101)
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10371089 — System for actuating an exhaust cowl

US 10371089	Peters et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	United Technologies Corporation (Hartford, Connecticut)
ASSIGNEE(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Donald W. Peters (Colchester, Connecticut); James P. Bangerter (Manchester, Connecticut)
ABSTRACT	In various embodiments, a cowl actuation system may comprise a cowl, an actuator, a bell crank, and a guide arm. The cowl may be configured to modulate at least a portion of the exhaust flow of a gas turbine engine. The bell crank may have a first end and a second end. The first end may be operatively coupled to the actuator. The second end may be operatively coupled to the cowl. The bell crank may be configured to pivot about a first point located between the first end and the second end. The first point may also be located along a diameter. The guide arm may have a third end and a fourth end. The third end may be mounted to a second point. The fourth end may be operatively coupled to the cowl. The second point may be located along the diameter.
FILED	Tuesday, January 20, 2015
APPL NO	14/600824
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/24 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/10 (20130101) Jet-propulsion Plants F02K 1/06 (20130101) Original (OR) Class F02K 1/09 (20130101) F02K 1/10 (20130101) F02K 1/15 (20130101) F02K 1/1261 (20130101) Gearing F16H 21/04 (20130101) F16H 21/54 (20130101)
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10371093 — Aircraft nozzle with a variable nozzle area of a second flow path

US 10371093	Baker et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Rolls-Royce North American Technologies, Inc. (Indianapolis, Indiana)
ASSIGNEE(S)	Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
INVENTOR(S)	Von D. Baker (Indianapolis, Indiana); Kenneth M. Pesyna (Indianapolis, Indiana)
ABSTRACT	A nozzle for an aircraft powerplant is disclosed which provides two separate flow paths. A flow path is provided in the nozzle for a core flow of the powerplant and another flow path is provided for a bypass flow of the powerplant. The nozzle can have a variety of configurations including, but not limited to, 2D and axisymmetric. Either or both the flow paths can be convergent, divergent, or convergent-divergent, and the flow paths need not be similar between the two. Actuators are provided to manipulate the configuration of the flow paths and the areas of the flow paths. For example, throat and/or exit areas can be manipulated.
FILED	Friday, March 07, 2014
APPL NO	14/200132
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Jet-propulsion Plants F02K 1/06 (20130101) F02K 1/15 (20130101) F02K 1/1215 (20130101) F02K 1/1246 (20130101) F02K 3/02 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2250/10 (20130101)
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10371237 — Belt wave drives

US 10371237	Koenig et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)	SRI International (Menlo Park, California)
INVENTOR(S)	Karen Shakespear Koenig (San Francisco, California); Pablo Eduardo Garcia Kilroy (Menlo Park, California)
ABSTRACT	A belt wave drive transmission system and method are shown involving a first rotor (10) having a first drum configured to rotate about its axis of rotation and a second rotor (20) having a second drum configured to rotate about its axis of rotation, where the first rotor (10) is constrained to orbit concentrically about the axis of rotation of the second drum. A belt (30) encircles the first and second drums to couple the first (10) and second (20) rotors such that the first rotor (10) moves concentrically around the second rotor (20) as the belt (30) advances about a circumference of the second drum. In further refinements, the system and method involve electrically controllably coupling at least one of the first and second rotors to the belt.
FILED	Friday, May 05, 2017
APPL NO	15/588293
ART UNIT	3654 — Material and Article Handling
CURRENT CPC	Gearing F16H 7/02 (20130101) F16H 9/26 (20130101) Original (OR) Class F16H 55/38 (20130101) F16H 55/54 (20130101) F16H 57/08 (20130101)
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10371263 — Hydraulic seal for non-mainshaft, rotating to static

US 10371263	Szymanski et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Life Cycle Management Center (AFLCMC)
APPLICANT(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
ASSIGNEE(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Grace E. Szymanski (Burlington, Connecticut); Justin Luong (Manchester, Connecticut)
ABSTRACT	A seal for reducing leakage about a rotating shaft having an axis includes a rotating component configured to be positioned radially outward from and surround the rotating shaft, and including a rotating cylinder defining an annular oil chamber for receiving oil. The seal also includes a static component including a sealing plate configured to extend into the annular oil chamber such that the oil fills a gap between the sealing plate and the rotating cylinder to reduce air leakage between the rotating component and the static component in response to rotation of the rotating component.
FILED	Friday, June 23, 2017
APPL NO	15/631714
ART UNIT	3675 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/003 (20130101) F01D 11/04 (20130101) F01D 25/183 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/60 (20130101) Pistons; Cylinders; Sealings F16J 15/42 (20130101) Original (OR) Class
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10371461 — Multi-layered counterflow expanding microchannel cooling architecture and system thereof

US 10371461	Chainer et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Timothy Joseph Chainer (Putnam Valley, New York); Pritish Ranjan Parida (Fishkill, New York); Fanghao Yang (Somerset, New Jersey)
ABSTRACT	Devices that have integrated cooling structures for counterflow, two-phase cooling and systems thereof are provided. In one example, a first structure can comprise a first cooling channel. The first cooling channel can have a first value of width that increases as the first cooling channel extends from a first side of a heat transfer area towards a second side of the heat transfer area. Also, a second structure can comprise a second cooing channel. The second cooling channel can have a second value of width that increases as the second cooling channel extends from the second side of the heat transfer area towards the first side of the heat transfer area.
FILED	Tuesday, October 11, 2016
APPL NO	15/290748
ART UNIT	3649 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 1/0341 (20130101) F28D 15/00 (20130101) F28D 15/025 (20130101) F28D 15/0233 (20130101) F28D 15/0258 (20130101) F28D 15/0266 (20130101) F28D 2021/0028 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 3/12 (20130101) F28F 3/086 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101) H01L 23/3736 (20130101) H01L 23/3737 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20309 (20130101)
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10371521 — Systems and methods for a four-mass vibrating MEMS structure

US 10371521	Johnson
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	Honeywell International Inc. (Morris Plains, New Jersey)
INVENTOR(S)	Burgess R. Johnson (Bloomington, Minnesota)
ABSTRACT	Systems and methods for a four-mass vibrating mems structure are provided. In certain implementations, a MEMS sensor includes four proof masses, wherein each proof mass is driven such that the proof masses oscillate along radial lines extending from the center of the MEMS sensor through the center of the respective proof mass, each proof mass comprising a plurality of drive combs; and a plurality of sense combs. In further embodiments, the MEMS sensor includes at least one substrate having one or more drive electrodes for driving the four proof masses along the radial lines at a drive frequency, wherein a resonant frequency of a sense mode is different from the drive frequency.
FILED	Wednesday, March 22, 2017
APPL NO	15/466784
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/574 (20130101) G01C 19/5656 (20130101) G01C 19/5712 (20130101) G01C 19/5747 (20130101) Original (OR) Class
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10371523 — Rotation and acceleration sensor based on superluminal ring lasers

US 10371523	Shahriar et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Missile Defense Agency (MDA) National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Digital Optics Technologies, Incorporated (Rolling Meadows, Illinois)
ASSIGNEE(S)	Digital Optics Technologies, Inc. (Rolling Meadows, Illinois)
INVENTOR(S)	Selim M. Shahriar (Kildeer, Illinois); Nicholas J. Condon (Evanston, Illinois); Devin J. Hileman (Des Plaines, Illinois); Shih C. Tseng (Arlington Heights, Illinois)
ABSTRACT	Ring laser gyroscopes, in which rotation is detected by the Sagnac effect between counterpropagating lasers, are in common use in navigation applications. The invention disclosed here uses an induced strong anomalous dispersion inside the ring laser cavities to create a group velocity of as much as 10⁶times greater than the vacuum speed of light, with a corresponding increase in gyroscope sensitivity; the resulting device is referred to as a Superluminal Ring Laser Gyroscope (SRLG). The invention disclosed here also incorporates an acceleration-sensing element that modifies the path length of the ring lasers in the gyroscope, the effects of which on the output of the gyroscope can be separated from those of rotation. The resulting composite device is a Superluminal Ring Laser Gyroscope/Accelerometer (SRLGA).
FILED	Wednesday, January 18, 2017
APPL NO	15/530464
ART UNIT	2886 — Optics
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/68 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/305 (20130101) H01S 3/0835 (20130101) H01S 3/2366 (20130101)
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10371618 — Maximum filter flow predictor

US 10371618	Steinert
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Systems Command (NAVAIR)
APPLICANT(S)	Bell Helicopter Textron Inc. (Fort Worth, Texas)
ASSIGNEE(S)	Bell Helicopter Textron Inc. (Forth Worth, Texas)
INVENTOR(S)	Alan H. Steinert (Fort Worth, Texas)
ABSTRACT	In one example embodiment, a filter condition measurement device features an engine data repository, one or more sensor units, and a measurement unit. The measurement system is configured to identify a first flow value corresponding to a sensed engine power value from the engine data repository, determine a filter coefficient for the filter as a function of the first flow value and the sensed delta-pressure value; identify a second engine power value from the plurality of stored engine power values and a second flow value corresponding to the second engine power value; and determine a second delta-pressure value for the air filter as a function of the filter coefficient and the second flow value.
FILED	Thursday, September 03, 2015
APPL NO	14/844865
ART UNIT	2817 — Semiconductors/Memory
CURRENT CPC	Separation B01D 46/0086 (20130101) B01D 2279/60 (20130101) Aeroplanes; Helicopters B64C 27/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0826 (20130101) Original (OR) Class G01N 2015/084 (20130101)
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10371668 — Apparatus and methods for probing a material as a function of depth using depth-dependent second harmonic generation

US 10371668	Garnett et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Energy (DOE)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee)
INVENTOR(S)	Joy Garnett (Nashville, Tennessee); Halina Krzyzanowska (Nashville, Tennessee); Norman H. Tolk (Brentwood, Tennessee)
ABSTRACT	A method for non-invasively probing at least one physics property of a solid material. In one embodiment, the method has the steps of splitting a photon beam into a first photon beam and a second photon beam, exposing the solid material to the first photon beam to generate a coherent acoustic phonon wave in the solid material at time t, and exposing the solid material to the second photon beam at a time t+Δt, where t+Δt≥t, to generate corresponding second harmonic generation signals, where from the corresponding second harmonic generation signals, the at least one physics property of the solid material is determinable.
FILED	Monday, July 13, 2015
APPL NO	15/324100
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/636 (20130101) G01N 21/8422 (20130101) G01N 21/9505 (20130101) G01N 29/043 (20130101) G01N 29/2418 (20130101) Original (OR) Class G01N 29/4454 (20130101) G01N 2021/8438 (20130101) G01N 2021/8477 (20130101)
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10371725 — Out-of-range voltage detection and protection

US 10371725	Morgado et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Xilinx, Inc. (San Jose, California)
ASSIGNEE(S)	XILINX, INC. (San Jose, California)
INVENTOR(S)	Alonso Morgado (Dublin, Ireland); Bruno Miguel Vaz (Sao Domingos de Rana, Portugal); Edward Cullen (Naas, Ireland); Christophe Erdmann (Dublin, Ireland)
ABSTRACT	Examples of the present disclosure provide out-of-range voltage detection and protection in integrated circuits (ICs). In some examples, an IC includes an envelope detector, a comparator, and a switch. The envelope detector is configured to generate an envelope signal of a signal and output the envelope signal on an output node of the envelope detector. A first input node of the comparator is coupled to the output node of the envelope detector. The comparator is configured to compare respective signals provided on the first and second input nodes of the comparator and generate a comparison signal in response to the comparison. The comparator is further configured to output the comparison signal on the output node of the comparator. The switch is connected between a protected node and a protection node and is configured to be selectively opened or closed based, at least in part, on the comparison signal.
FILED	Thursday, May 31, 2018
APPL NO	15/994060
ART UNIT	2685 — Selective Communication
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 19/16528 (20130101) G01R 19/16595 (20130101) Original (OR) Class Emergency Protective Circuit Arrangements H02H 9/046 (20130101) Pulse Technique H03K 19/00315 (20130101) H03K 19/00384 (20130101)
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10371873 — High fidelity optical beam dump

US 10371873	Staver et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Philip R Staver (Wilton, New Hampshire); Adam J Marcinuk (Lyndeborough, New Hampshire)
ABSTRACT	A high efficiency optical beam dump having at least two glass plates configured to define an optical path configured to reflect a beam incident the optical path from plate to plate, wherein the plates include anti-reflective coatings and high reflective coatings and wherein the high-efficiency optical beam dump is capable of very high levels of attenuation through repetitive absorption and reflection of an optical beam.
FILED	Wednesday, December 07, 2016
APPL NO	15/371972
ART UNIT	2872 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 5/003 (20130101) Original (OR) Class
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10371898 — Enhanced coupling strength grating having a cover layer

US 10371898	Evans et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Southern Methodist University (Dallas, Texas); Oracle International Corporation (Redwood Shores, California)
ASSIGNEE(S)	Southern Methodist University (Dallas, Texas)
INVENTOR(S)	Gary A. Evans (Plano, Texas); Jerome K. Butler (Richardson, Texas); Jay B. Kirk (Plano, Texas); Ruo-Hua He (Dallas, Texas); Jin Yao (San Diego, California); Guoliang Li (San Diego, California); Xuezhe Zheng (San Diego, California); Ashok V. Krishnamoorthy (San Diego, California)
ABSTRACT	The present invention includes an optical waveguide with a grating and a method of making the same for increasing the effectiveness of the grating. In one example, the grating is at least partially covered by a liner layer disposed on at least a portion of a grating; and a cover layer disposed on the liner layer, wherein a first material selected for the core and ridges and a second material selected for the liner layer are selected to provide a difference in the index of refraction between the first and second material that is sufficient to provide a contrast therebetween.
FILED	Friday, September 05, 2014
APPL NO	14/479039
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/34 (20130101) Original (OR) Class G02B 6/036 (20130101) G02B 6/132 (20130101) G02B 6/136 (20130101) G02B 6/1223 (20130101) G02B 2006/12107 (20130101) G02B 2006/12176 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0635 (20130101) H01S 5/12 (20130101) H01S 5/125 (20130101) H01S 5/187 (20130101) H01S 5/1231 (20130101)
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10371906 — Method and apparatus for delivering the fiber laser radiation into dynamical waveguide

US 10371906	Beresnev et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Leonid A. Beresnev (Columbia, Maryland); Anthony R. Valenzuela (Baltimore, Maryland); Chatt C. Williamson (Mt. Airy, Maryland)
ABSTRACT	A technique for delivery of a divergent laser beam emitted with a free-space laser fiber facet, the beam having an optical power, into an optical waveguide. An optical axis of the laser beam is aligned approximately along a propagation Z direction into the optical waveguide. The fiber facet is located in a first plane perpendicular to the Z direction. The waveguide includes an input, direction, and X-Y position of the input in a second plane. The waveguide includes fluctuations in a X-Y-Z position of the input and fluctuations in direction. The laser beam is transformed into a collimated beam by re-directing a propagation of the laser beam, shifting the laser beam parallel to the Z direction, and focusing the laser beam into the input. The speed of transformation of the laser beam is greater than an instant speed of the fluctuations. A maximum optical power is delivered into the waveguide.
FILED	Wednesday, January 17, 2018
APPL NO	15/873143
ART UNIT	2874 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/32 (20130101) G02B 6/262 (20130101) G02B 6/4225 (20130101) Original (OR) Class G02B 6/4227 (20130101) G02B 6/4296 (20130101) G02B 7/02 (20130101) G02B 27/40 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/005 (20130101) H01S 3/11 (20130101) H01S 3/06708 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/46 (20130101)
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10372115 — Modular and reconfigurable manufacturing systems

US 10372115	Das et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Aditya Narayan Das (Irving, Texas); Stephen Savoie (Arlington, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Aditya Narayan Das (Irving, Texas); Stephen Savoie (Arlington, Texas)
ABSTRACT	In one embodiment, a manufacturing system includes multiple manipulation modules each including means for mechanically and electrically connecting the module to another component in the system and an end effector including means for mechanically and electrically connecting the end effector to another component in the system, wherein the modules and end effector can be mechanically and electrically connected in multiple ways to alter the configuration of the system and the manufacturing tasks that the system can perform.
FILED	Wednesday, October 23, 2013
APPL NO	14/061063
ART UNIT	2118 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Details, Components, or Accessories for Machine Tools, e.g Arrangements for Copying or Controlling; Machine Tools in General Characterised by the Construction of Particular Details or Components; Combinations or Associations of Metal-working Machines, Not Directed to a Particular Result B23Q 37/005 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/41845 (20130101) Original (OR) Class G05B 2219/31044 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 90/04 (20151101) Y02P 90/16 (20151101) Y02P 90/185 (20151101)
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10372428 — Dynamic computational acceleration using a heterogeneous hardware infrastructure

US 10372428	Powers et al.
FUNDED BY	Department of Defense (DOD) Missile Defense Agency (MDA)
APPLICANT(S)	Architecture Technology Corporation (Minneapolis, Minnesota)
ASSIGNEE(S)	Architecture Technology Corporation (Minneapolis, Minnesota)
INVENTOR(S)	Judson Powers (Ithaca, New York); Noel E. Schmidt (Bloomington, Minnesota)
ABSTRACT	An example method includes, during execution of a software application in a computing system comprising a plurality of processing units, identifying platform-independent instructions that are configured to perform at least one computational task, wherein the plurality of processing units comprises a heterogeneous group, and wherein the platform-independent instructions have a format that is not specific to any particular processing unit in the plurality of processing units, determining one or more scheduling criteria that are associated with the platform-independent instructions, and selecting, from the heterogeneous group of processing units and based on the scheduling criteria, a processing unit to perform the at least one computational task. The example method further includes converting the platform-independent instructions into platform-dependent instructions, wherein the platform-dependent instructions have a format that is specific to the selected processing unit, and executing, by the selected processing unit, the platform-dependent instructions to perform the at least one computational task.
FILED	Thursday, May 24, 2018
APPL NO	15/989064
ART UNIT	2192 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 8/41 (20130101) Original (OR) Class G06F 8/447 (20130101) G06F 8/451 (20130101) G06F 9/46 (20130101) G06F 9/455 (20130101) G06F 9/4843 (20130101) G06F 9/4881 (20130101) G06F 9/45504 (20130101) G06F 9/45516 (20130101)
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10372587 — Electronic device monitoring using induced electromagnetic emissions from software stress techniques

US 10372587	Sternberg et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as represented by Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Oren Sternberg (San Diego, California); John D. Rockway (San Diego, California); Mitchell Lerner (San Diego, California); Israel Perez (Newport, Rhode Island)
ABSTRACT	A method involves using one or more software programs to stress a powered electronic device in a test environment to induce controlled electromagnetic emissions from the powered electronic device, using the controlled electromagnetic emissions to generate an emission profile of the powered electronic device operating under stress, monitoring spurious electromagnetic emissions of the powered electronic device in an operational environment, and comparing the spurious electromagnetic emissions of the powered electronic device in the operational environment with the emission profile of the powered electronic device to determine that the powered electronic device is operating under stress in the operational environment.
FILED	Wednesday, November 09, 2016
APPL NO	15/347393
ART UNIT	2864 — Printing/Measuring and Testing
CURRENT CPC	Electric Digital Data Processing G06F 11/3612 (20130101) G06F 11/3616 (20130101) Original (OR) Class
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10372714 — Automated determination of document utility for a document corpus

US 10372714	Beller et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Charles Evan Beller (Baltimore, Maryland); William G Dubyak (Severna Park, Maryland); Palani Sakthi (Palatine, Illinois); Kristen Maria Summers (Takoma Park, Maryland)
ABSTRACT	A candidate document is received, for example, by a document filter. A determination is made based on the content of the candidate document, whether the candidate document is relevant to a document corpus. A determination is made based on the content of the candidate document, whether the candidate document is novel with respect to the document corpus. In response to determining that the candidate document is relevant to the document corpus and novel with respect to the document corpus, the candidate document is added to the document corpus to make at least a portion of the content of the candidate document available for a response to a search query.
FILED	Friday, February 05, 2016
APPL NO	15/017089
ART UNIT	2152 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/93 (20190101) G06F 16/248 (20190101) G06F 16/332 (20190101) G06F 16/3334 (20190101) G06F 16/9535 (20190101) G06F 16/24575 (20190101) Original (OR) Class G06F 17/2765 (20130101)
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10372816 — Preprocessing of string inputs in natural language processing

US 10372816	Beller et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Charles E. Beller (Baltimore, Maryland); Chengmin Ding (Chantilly, Virginia); Allen Ginsberg (St. Petersburg, Florida); Elinna Shek (Herndon, Virginia)
ABSTRACT	Natural language processing of raw text data for optimal sentence boundary placement. Raw text is extracted from a document and subject to cleaning. The extracted raw text is examined to identify preliminary sentence boundaries, which are used to identify potential sentences in the raw text. One or more potential sentences are assigned a well-formedness score. A value of the score correlates to whether the potential sentence is a truncated/ill-formed sentence or a well-formed sentence. One or more preliminary sentence boundaries are optimized depending on the value of the score of the potential sentence(s). Accordingly, the processing herein is an optimization that creates a sentence boundary optimized output.
FILED	Tuesday, December 13, 2016
APPL NO	15/376923
ART UNIT	2659 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 17/274 (20130101) Original (OR) Class G06F 17/2705 (20130101) G06F 17/2775 (20130101) G06F 17/2785 (20130101)
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10372823 — Nonlinear semantic space based on lexical graph

US 10372823	Moon et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Hankyu Moon (Oak Park, California); Rajan Bhattacharyya (Sherman Oaks, California); James Benvenuto (Beverly Hills, California)
ABSTRACT	Described is a system for generating a semantic space based on the lexical relations between words. The system determines synonym and antonym relations between a set of words. A lexical graph is generated based on the synonym and antonym relations. Manifold embedding of the lexical graph is determined, and Laplacian coordinates of the manifold embedding are assigned as semantic features of the set of words. A quantitative representation of the set of words is generated using the semantic features.
FILED	Friday, October 21, 2016
APPL NO	15/331424
ART UNIT	2658 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 17/277 (20130101) G06F 17/2785 (20130101) Original (OR) Class G06F 17/2795 (20130101)
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10373335 — System and method for location recognition and learning utilizing convolutional neural networks for robotic exploration

US 10373335	Chen et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Yang Chen (Westlake Village, California); Jiejun Xu (Chino, California); Deepak Khosla (Camarillo, California)
ABSTRACT	Described is a system for location recognition for mobile platforms, such as autonomous robotic exploration. In operation, an image in front of the platform is converted into a high-dimensional feature vector. The image reflects a scene proximate the mobile platform. A candidate location identification of the scene is then determined. The candidate location identification is then stored in a history buffer. Upon receiving a cue, the system then determines if the candidate location identification is a known location or a new location.
FILED	Thursday, January 05, 2017
APPL NO	15/399429
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00664 (20130101) G06K 9/00791 (20130101) G06K 9/6276 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 5/046 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 7/75 (20170101) Original (OR) Class
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10373339 — Hyperspectral scene analysis via structure from motion

US 10373339	Miller et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Corey A. Miller (Alexandria, Virginia); Thomas J. Walls (Springfield, Virginia)
ABSTRACT	A method for determining structure from motion in hyperspectral imaging includes acquiring hyperspectral data cubes containing intensity data, the intensity data being stored in dimensions of the hyperspectral data cube including a first spatial dimension, a second spatial dimension, and a spectrum dimension; establishing a set of baseline spectral features from a data cube for tracking between data cubes; establishing a set of standard features from a data cube for tacking between data cubes; matching, between data cubes, respective baseline features and standard features; and extracting imaging device motion information based on relative positions of matched baseline and standard features.
FILED	Wednesday, December 14, 2016
APPL NO	15/379166
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00637 (20130101) Image Data Processing or Generation, in General G06T 7/74 (20170101) G06T 7/90 (20170101) Original (OR) Class G06T 7/248 (20170101)
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10373702 — Water-soluble trans-membrane proteins and methods for the preparation and use thereof

US 10373702	Zhang et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Shuguang Zhang (Lexington, Massachusetts); Fei Tao (Cambridge, Massachusetts)
ABSTRACT	The present invention is directed to a computer implemented method for executing a procedure to select a water-soluble variant of a G Protein-Coupled Receptor (GPCR).
FILED	Wednesday, May 27, 2015
APPL NO	14/723399
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 14/705 (20130101) C07K 14/723 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Original (OR) Class G16B 35/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/60 (20190201)
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10373928 — Method for electrically interconnecting at least two substrates and multichip module

US 10373928	Dotsenko
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Communications-Electronics Research, Development and Engineering Center (CERDEC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Hypres, Inc. (Elmsford, New York)
ASSIGNEE(S)	Hypres, inc. (Elmsford, New York)
INVENTOR(S)	Vladimir V. Dotsenko (Mahopac, New York)
ABSTRACT	A method for electrically interconnecting two substrates, each having a corresponding set of preformed electrical contacts, the substrates comprising an electronic circuit, and the resulting module, is provided. A liquid curable adhesive is provided over the set of contacts of a first substrate, and the set of electrical contacts of the second substrate is aligned with the set of electrical contacts of the first substrate. The sets of electrical contacts of the first and second substrate are compressed to displace the liquid curable adhesive from the inter-contact region, and provide electrical communication between the respective sets of electrical contacts. The liquid curable adhesive is then cured to form a solid matrix which maintains a relative compression between the respective sets of electrical contacts. One embodiment of the module comprises a high-speed superconducting circuit which operates at cryogenic temperatures.
FILED	Monday, May 01, 2017
APPL NO	15/583414
ART UNIT	2848 — Electrical Circuits and Systems
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 24/13 (20130101) H01L 24/29 (20130101) H01L 24/73 (20130101) H01L 24/83 (20130101) Original (OR) Class H01L 25/04 (20130101) H01L 25/50 (20130101) H01L 39/045 (20130101) H01L 39/2493 (20130101) H01L 2224/2919 (20130101) H01L 2224/13109 (20130101) H01L 2224/13111 (20130101) H01L 2224/73204 (20130101) H01L 2224/83862 (20130101) H01L 2924/0132 (20130101) H01L 2924/0665 (20130101)
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10373998 — Compact annular field imager optical interconnect

US 10373998	Vincentsen et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	David M. Vincentsen (Bethlehem, Pennsylvania); Jonas D. Corl (Bethlehem, Pennsylvania); Thomas A. Mitchell (Nazareth, Pennsylvania); Michelle M. Stone (Hellertown, Pennsylvania); Thomas W. Stone (Hellertown, Pennsylvania); Randall C. Veitch (Walnutport, Pennsylvania)
ASSIGNEE(S)	Wavefront Research, Inc. (Bethlehem, Pennsylvania)
INVENTOR(S)	David M. Vincentsen (Bethlehem, Pennsylvania); Jonas D. Corl (Bethlehem, Pennsylvania); Thomas A. Mitchell (Nazareth, Pennsylvania); Michelle M. Stone (Hellertown, Pennsylvania); Thomas W. Stone (Hellertown, Pennsylvania); Randall C. Veitch (Walnutport, Pennsylvania)
ABSTRACT	The present disclosure provides an optoelectronic module. In one aspect, the optoelectronic module includes an insertion member including a housing insert and an imager disposed in the housing insert, and a receiving member including an interposer, a housing disposed on the interposer, and an optoelectronic device electrically connected to said interposer. The housing of the receiving member is configured to engage and receive the housing insert of the insertion member, The optoelectronic device of the receiving member is configured to align with the imager of the insertion member.
FILED	Friday, March 14, 2014
APPL NO	14/213014
ART UNIT	2878 — Optics
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14636 (20130101) Original (OR) Class
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10374072 — Methods and devices for fabricating and assembling printable semiconductor elements

US 10374072	Nuzzo et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of Energy (DOE) Office of Science (DOE-SC) Materials Sciences and Engineering Division (MSE)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Ralph G. Nuzzo (Champaign, Illinois); John A. Rogers (Champaign, Illinois); Etienne Menard (Voglans, France); Keon Jae Lee (Daejeon, South Korea); Dahl-Young Khang (Seoul, South Korea); Yugang Sun (Gladwyne, Pennsylvania); Matthew Meitl (Durham, North Carolina); Zhengtao Zhu (Rapid City, South Dakota)
ABSTRACT	The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.
FILED	Friday, June 30, 2017
APPL NO	15/640206
ART UNIT	2829 — Semiconductors/Memory
CURRENT CPC	Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 2201/0185 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/308 (20130101) H01L 21/322 (20130101) H01L 21/02521 (20130101) H01L 21/02603 (20130101) H01L 21/02628 (20130101) H01L 21/6835 (20130101) H01L 23/02 (20130101) H01L 24/03 (20130101) H01L 24/05 (20130101) H01L 24/08 (20130101) H01L 24/29 (20130101) H01L 24/32 (20130101) H01L 24/80 (20130101) H01L 24/83 (20130101) H01L 24/94 (20130101) H01L 24/97 (20130101) H01L 25/0753 (20130101) H01L 27/1285 (20130101) H01L 27/1292 (20130101) H01L 29/04 (20130101) H01L 29/06 (20130101) H01L 29/12 (20130101) H01L 29/068 (20130101) H01L 29/76 (20130101) Original (OR) Class H01L 29/0665 (20130101) H01L 29/0673 (20130101) H01L 29/0676 (20130101) H01L 29/78603 (20130101) H01L 29/78681 (20130101) H01L 29/78696 (20130101) H01L 31/0392 (20130101) H01L 31/1804 (20130101) H01L 31/1864 (20130101) H01L 31/1896 (20130101) H01L 31/03926 (20130101) H01L 33/007 (20130101) H01L 33/32 (20130101) H01L 33/0079 (20130101) H01L 2221/68368 (20130101) H01L 2221/68381 (20130101) H01L 2224/03 (20130101) H01L 2224/03 (20130101) H01L 2224/03 (20130101) H01L 2224/80 (20130101) H01L 2224/80 (20130101) H01L 2224/83 (20130101) H01L 2224/83 (20130101) H01L 2224/94 (20130101) H01L 2224/94 (20130101) H01L 2224/95 (20130101) H01L 2224/97 (20130101) H01L 2224/97 (20130101) H01L 2224/97 (20130101) H01L 2224/0332 (20130101) H01L 2224/0332 (20130101) H01L 2224/0345 (20130101) H01L 2224/0362 (20130101) H01L 2224/2919 (20130101) H01L 2224/2919 (20130101) H01L 2224/03614 (20130101) H01L 2224/05073 (20130101) H01L 2224/05073 (20130101) H01L 2224/05082 (20130101) H01L 2224/05082 (20130101) H01L 2224/05124 (20130101) H01L 2224/05124 (20130101) H01L 2224/05144 (20130101) H01L 2224/05144 (20130101) H01L 2224/05144 (20130101) H01L 2224/05155 (20130101) H01L 2224/05155 (20130101) H01L 2224/05155 (20130101) H01L 2224/05166 (20130101) H01L 2224/05166 (20130101) H01L 2224/05166 (20130101) H01L 2224/05552 (20130101) H01L 2224/05552 (20130101) H01L 2224/05553 (20130101) H01L 2224/05553 (20130101) H01L 2224/05554 (20130101) H01L 2224/05554 (20130101) H01L 2224/05555 (20130101) H01L 2224/05555 (20130101) H01L 2224/05644 (20130101) H01L 2224/05644 (20130101) H01L 2224/05644 (20130101) H01L 2224/05644 (20130101) H01L 2224/05666 (20130101) H01L 2224/05666 (20130101) H01L 2224/08225 (20130101) H01L 2224/8385 (20130101) H01L 2224/9202 (20130101) H01L 2224/9202 (20130101) H01L 2224/32225 (20130101) H01L 2224/32225 (20130101) H01L 2224/80006 (20130101) H01L 2224/80121 (20130101) H01L 2224/80121 (20130101) H01L 2224/80862 (20130101) H01L 2224/80895 (20130101) H01L 2224/83005 (20130101) H01L 2224/83121 (20130101) H01L 2224/83121 (20130101) H01L 2224/83192 (20130101) H01L 2224/83192 (20130101) H01L 2224/83193 (20130101) H01L 2224/83862 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00012 (20130101) H01L 2924/00012 (20130101) H01L 2924/00012 (20130101) H01L 2924/00012 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/14 (20130101) H01L 2924/14 (20130101) H01L 2924/0665 (20130101) H01L 2924/0665 (20130101) H01L 2924/01032 (20130101) H01L 2924/01032 (20130101) H01L 2924/01032 (20130101) H01L 2924/1305 (20130101) H01L 2924/1305 (20130101) H01L 2924/1306 (20130101) H01L 2924/1306 (20130101) H01L 2924/1461 (20130101) H01L 2924/1461 (20130101) H01L 2924/1579 (20130101) H01L 2924/10253 (20130101) H01L 2924/10329 (20130101) H01L 2924/12032 (20130101) H01L 2924/12032 (20130101) H01L 2924/12036 (20130101) H01L 2924/12036 (20130101) H01L 2924/12041 (20130101) H01L 2924/12042 (20130101) H01L 2924/12042 (20130101) H01L 2924/12043 (20130101) H01L 2924/12043 (20130101) H01L 2924/12044 (20130101) H01L 2924/12044 (20130101) H01L 2924/13063 (20130101) H01L 2924/13063 (20130101) H01L 2924/13091 (20130101) H01L 2924/13091 (20130101) H01L 2924/15159 (20130101) H01L 2924/15162 (20130101) H01L 2924/15788 (20130101) H01L 2924/15788 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/547 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/521 (20151101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/707 (20130101) Y10S 977/724 (20130101)
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10374112 — Inverted metamorphic multijunction solar cell including a metamorphic layer

US 10374112	Cornfeld et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	SolAero Technologies Corp. (Albuquerque, New Mexico)
ASSIGNEE(S)	SolAero Technologies Corp. (Albuquerque, New Mexico)
INVENTOR(S)	Arthur Cornfeld (Sandy Springs, Georgia); Pravin Patel (Albuquerque, New Mexico); Mark A. Stan (Albuquerque, New Mexico); Benjamin Cho (Albuquerque, New Mexico); Paul R. Sharps (Albuquerque, New Mexico); Daniel J. Aiken (Cedar Crest, New Mexico); John Spann (Albuquerque, New Mexico)
ABSTRACT	A multijunction solar cell includes an upper first solar subcell, a second solar subcell adjacent to the first solar subcell, a third solar subcell adjacent to the second solar subcell, and a graded interlayer adjacent to the third solar subcell. The graded interlayer has a band gap that is greater than the band gap of the third solar subcell and is composed of a compositionally step-graded series of (In_xGa_1-x)_yAl_1-yAs layers with monotonically changing lattice constant, with x and y having respective values such that the band gap of the graded interlayer remains constant throughout its thickness, and wherein 0<x<1 and 0<y<1. A fourth solar subcell is adjacent to the graded interlayer and is lattice mismatched with respect to the third solar subcell. The graded interlayer provides a transition in lattice constant from the third solar subcell to the fourth solar subcell. A lower fifth solar subcell is adjacent to the fourth solar subcell.
FILED	Wednesday, February 17, 2016
APPL NO	15/045641
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/078 (20130101) H01L 31/1844 (20130101) H01L 31/1892 (20130101) H01L 31/06875 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/544 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/521 (20151101)
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10374118 — Silicon germanium photodetector apparatus and other semiconductor devices including curved-shape silicon germanium structures

US 10374118	Alloatti et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Luca Alloatti (Staefa, Switzerland); Rajeev Jagga Ram (Arlington, Massachusetts); Dinis Cheian (Brooklyn, New York)
ABSTRACT	Semiconductor devices, such as photonics devices, employ substantially curved-shaped Silicon-Germanium (SiGe) structures and are fabricated using zero-change CMOS fabrication process technologies. In one example, a closed-loop resonator waveguide-coupled photodetector includes a silicon resonator structure formed in a silicon substrate, interdigitated n-doped well-implant regions and p-doped well-implant regions forming multiple silicon p-n junctions around the silicon resonator structure, and a closed-loop SiGe photocarrier generation region formed in a pocket within the interdigitated n-doped and p-doped well implant regions. The closed-loop SiGe region is located so as to substantially overlap with an optical mode of radiation when present in the silicon resonator structure, and traverses the multiple silicon p-n junctions around the silicon resonator structure. Electric fields arising from the respective p-n silicon junctions significantly facilitate a flow of the generated photocarriers between electric contact regions of the photodetector.
FILED	Monday, October 24, 2016
APPL NO	15/332877
ART UNIT	2894 — Semiconductors/Memory
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/12004 (20130101) G02B 6/29338 (20130101) G02B 2006/12123 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/103 (20130101) H01L 31/0232 (20130101) H01L 31/0312 (20130101) H01L 31/1037 (20130101) H01L 31/1105 (20130101) H01L 31/1812 (20130101) Original (OR) Class H01L 31/02327 (20130101) H01L 31/03529 (20130101) H01L 31/022408 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101)
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10374155 — Electrically actuated switch

US 10374155	Williams
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	R. Stanley Williams (Portola Valley, California)
ABSTRACT	An electrically actuated switch comprises a first electrode, a second electrode, and an active region disposed therebetween. The active region comprises at least one primary active region comprising at least one material that can be doped or undoped to change its electrical conductivity, and a secondary active region comprising at least one material for providing a source/sink of ionic species that act as dopants for the primary active region(s). Methods of operating the switch are also provided.
FILED	Tuesday, July 18, 2017
APPL NO	15/653210
ART UNIT	2893 — Semiconductors/Memory
CURRENT CPC	Static Stores G11C 13/0007 (20130101) G11C 13/0009 (20130101) G11C 2213/52 (20130101) G11C 2213/53 (20130101) G11C 2213/56 (20130101) G11C 2213/77 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/2463 (20130101) H01L 45/08 (20130101) Original (OR) Class H01L 45/14 (20130101) H01L 45/145 (20130101) H01L 45/146 (20130101) H01L 45/147 (20130101) H01L 45/1206 (20130101) H01L 45/1233 (20130101) Pulse Technique H03K 17/00 (20130101)
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10374235 — System and method for improving power production in linear array benthic microbial fuel cells

US 10374235	Chadwick et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	David B. Chadwick (San Diego, California); Yolanda Meriah Arias-Thode (San Diego, California); Andrew Higier (San Diego, California); Lewis Hsu (San Diego, California); Kenneth E. Richter (San Diego, California); Alex G. Phipps (San Diego, California); Gregory W. Anderson (San Diego, California)
ABSTRACT	A method for improving power production comprising the steps of providing an existing linear array benthic microbial fuel cell system having an anode and a plurality of cathodes, wherein the anode is an insulated underwater cable buried beneath seafloor sediment, and wherein the plurality of cathodes are configured to be buoyant and to rise above the sea floor, wrapping the insulated underwater cable with carbon fiber bundles and a current collector, wherein the carbon fiber is coated with a binder, securing the carbon fiber bundles and current collector with a web of synthetic fiber, fraying the carbon fiber bundles, creating exposed carbon ends on the cable and removing the binder.
FILED	Tuesday, September 26, 2017
APPL NO	15/716433
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/88 (20130101) H01M 4/96 (20130101) H01M 4/8657 (20130101) Original (OR) Class H01M 8/004 (20130101) H01M 8/08 (20130101) H01M 8/16 (20130101) H01M 8/0206 (20130101) H01M 2250/10 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 90/14 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/527 (20130101)
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10374379 — Systems, apparatus, and methods for laser amplification in fiber amplifiers

US 10374379	Augst
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Steven J. Augst (Acton, Massachusetts)
ABSTRACT	A fiber amplifier includes an isolator, a gain fiber to amplify an input laser signal, and an optical filter disposed between the isolator and the gain fiber. The optical filter transmits the laser signal and reflects amplified spontaneous emission (ASE) propagating from the gain fiber toward the isolator. The reflected ASE reenters the gain fiber and is absorbed by the gain fiber for amplifying the input laser signal. The optical filter in the amplifier can protect the usually expensive isolator and reduce potential damage to the gain fiber induced by fluctuation of the input laser signal power, as well as reduce potential photodarkening at the input of the gain fiber.
FILED	Friday, September 09, 2016
APPL NO	15/261541
ART UNIT	3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0014 (20130101) H01S 3/0064 (20130101) H01S 3/0078 (20130101) H01S 3/161 (20130101) H01S 3/0675 (20130101) H01S 3/1608 (20130101) H01S 3/1616 (20130101) H01S 3/1618 (20130101) H01S 3/06754 (20130101) Original (OR) Class H01S 3/06758 (20130101) H01S 3/08009 (20130101) H01S 3/09408 (20130101) H01S 3/09415 (20130101) H01S 3/10015 (20130101) H01S 3/10023 (20130101) H01S 3/094023 (20130101) H01S 2301/02 (20130101)
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10374389 — Plasmonic mode III-V laser as on-chip light source

US 10374389	Li et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York); The George Washington University (Washington, District of Columbia)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York); The George Washington University (Washington, District of Columbia)
INVENTOR(S)	Ning Li (White Plains, New York); Ke Liu (Arlington, Virginia); Devendra K. Sadana (Pleasantville, New York); Volker J. Sorger (Alexandria, Virginia)
ABSTRACT	A plasmonic light source includes a substrate and a square nano-cavity formed on the substrate. The nano-cavity includes a quantum well structure. The quantum well structure includes III-V materials. A plasmonic metal is formed as an electrode on the square nano-cavity and is configured to excite surface plasmons with the quantum well structure to generate light. Complementary metal oxide semiconductor (CMOS) devices are formed on the substrate.
FILED	Thursday, March 30, 2017
APPL NO	15/474534
ART UNIT	2874 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/43 (20130101) G02B 6/136 (20130101) G02B 6/12002 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/021 (20130101) H01S 5/026 (20130101) H01S 5/0425 (20130101) Original (OR) Class H01S 5/1042 (20130101) H01S 5/1046 (20130101) H01S 5/3401 (20130101) H01S 5/34346 (20130101)
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10374552 — Mixer driver circuit with improved slew rate

US 10374552	Jansen
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Douglas S. Jansen (Pelham, New Hampshire)
ABSTRACT	A mixer device is disclosed, which is fabricated as a bipolar-complementary metal oxide semiconductor (BiCMOS) integrated circuit device, to provide improved linearity and dynamic range, at higher operating frequencies. A mixer device configured according to an embodiment includes a driver circuit comprising bipolar junction transistors (BJTs) to convert a local oscillator signal to a high slew-rate gate drive signal. The driver circuit is configured as a quasi-complementary driver employing NPN BJTs. The mixer device further includes a mixer circuit comprising CMOS field-effect transistors (FETs) configured to mix an input signal with the gate drive signal to generate an output signal through the application of the gate drive signal to the gate port of the CMOS FETs. The mixer device further includes a voltage biasing circuit to provide a biased body voltage to the FETs to allow overdriving to a negative voltage relative to the body voltage.
FILED	Friday, April 13, 2018
APPL NO	15/952868
ART UNIT	2632 — Digital Communications
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/8249 (20130101) H01L 27/0623 (20130101) H01L 29/737 (20130101) Demodulation or Transference of Modulation From One Carrier to Another H03D 7/145 (20130101) Original (OR) Class H03D 7/1458 (20130101) Transmission H04B 1/16 (20130101)
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10374723 — Apparatus and methods for power efficient multi-format optical transmission

US 10374723	Caplan
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	David O. Caplan (Westford, Massachusetts)
ABSTRACT	An apparatus for generating a processed optical signal includes a first laser configured to emit a first optical signal in response to a first drive signal. The first optical signal has a first phase shift depending on a first integrated amplitude of the first drive signal. The apparatus also includes a spectral-temporal filter, in optical communication with the first laser, to change a first spectral profile and a first temporal profile of the first optical pulse so as to generate the processed optical signal. Replacing a conventional continuous-wave (CW) laser and external modulation with filter-based modulation can achieve the same or better performance without high-fidelity low-noise input signals.
FILED	Friday, January 26, 2018
APPL NO	15/881388
ART UNIT	2636 — Optical Communications
CURRENT CPC	Transmission H04B 10/11 (20130101) H04B 10/556 (20130101) H04B 10/677 (20130101) H04B 10/5055 (20130101) H04B 10/5561 (20130101) Original (OR) Class H04B 10/50577 (20130101) Multiplex Communication H04J 14/02 (20130101)
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10375169 — System and method for automatically triggering the live migration of cloud services and automatically performing the triggered migration

US 10375169	Diallo et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Mamadou H. Diallo (Santee, California); Michael A. August (San Diego, California); Megan E. Kline (Chula Vista, California); Scott M. Slayback (San Diego, California); Roger A. Hallman (San Diego, California)
ABSTRACT	A system and method maximize the availability of cloud services in the event of a disruption to one or more cloud servers by automatically triggering the live migration of selected cloud services and automatically performing the triggered migration of such services. The operational state of virtual machines operating on a cloud server and the services that are associated with the virtual machines is monitored. Different techniques are used for deciding when to migrate cloud services based on the automatic detection of anomalies, for deciding what cloud services to migrate so as to maximize the availability of high priority services during migration under time and network bandwidth constraints, and for deciding where to migrate the selected cloud services based on a determination of the best location for migration.
FILED	Wednesday, May 24, 2017
APPL NO	15/604552
ART UNIT	2457 — Computer Networks
CURRENT CPC	Electric Digital Data Processing G06F 11/1484 (20130101) G06F 11/3409 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1425 (20130101) H04L 67/42 (20130101) H04L 67/1097 (20130101) Original (OR) Class
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10375264 — Multispectral lighting reproduction

US 10375264	Debevec et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	University of Southern California (Los Angeles, California)
ASSIGNEE(S)	University of Southern California (Los Angeles, California)
INVENTOR(S)	Paul E. Debevec (Marina del Ray, California); Chloe Legendre (Los Angeles, California); Sumanta Pattanaik (Orlando, Florida)
ABSTRACT	Systems and techniques for multispectral lighting reproduction, in one aspect, include: one or more light sources having different lighting spectra; and one or more computers comprising at least one processor and at least one memory device, the one or more computers programmed to drive the one or more light sources directly using intensity coefficients that have been determined by comparing first data for a multi-color reference object photographed by a camera in a scene with second data for the multi-color reference object photographed when lit by respective ones of the different lighting spectra of the one or more light sources.
FILED	Friday, April 28, 2017
APPL NO	15/582522
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/505 (20130101) Image Data Processing or Generation, in General G06T 15/50 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 13/19634 (20130101) Pictorial Communication, e.g Television H04N 1/64 (20130101) H04N 1/0284 (20130101) Original (OR) Class H04N 1/6086 (20130101)
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10375385 — Video timing test equipment for measuring light integration time of a camera

US 10375385	Witzel et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the the Navy (Washington, District of Columbia)
INVENTOR(S)	Jason Witzel (Ridgecrest, California); James Alexander Rogers (Ridgecrest, California)
ABSTRACT	A video timing test equipment for measuring light integration time of a camera. The video timing test equipment may comprise: a control unit and shutter timing test unit. The control unit may generate input timing signals adjustable by a user. The shutter timing test unit may comprise a single timing light emitting diode (LED), a single timing infrared (IR) LED, and an output controller. The output controller may regulate the illumination of the timing LED and timing IR LED based on the input timing signals. The shutter timing test unit may also comprise a UTC time display, edge time display, and pulse width display. The UTC time display may depict a UTC time as to when light integration begins or ends. The edge time display may depict an offset time associated with the start or end of light integration. The pulse width display may depict the duration of light integration.
FILED	Wednesday, August 29, 2018
APPL NO	16/116442
ART UNIT	2422 — Cable and Television
CURRENT CPC	Pictorial Communication, e.g Television H04N 17/002 (20130101) Original (OR) Class
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10375467 — Systems, apparatus, and methods for hearing protection

US 10375467	Xu et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Jun Xu (Medford, Massachusetts); Nicholas Fang (Lexington, Massachusetts)
ABSTRACT	Systems, apparatus, and methods for filtering acoustic energy include a first conduit substantially aligned with a longitudinal axis and defining a first opening for receiving incident acoustic energy from the environment. A cavity in fluid communication with the first conduit selectively amplifies and/or dampens the acoustic energy based on an associated resonance frequency. A moving element disposed in the cavity may be displaced relative to the cavity in a direction substantially aligned with the longitudinal axis and in an amount related to a sound pressure level of acoustic energy in the cavity. A second conduit substantially aligned with the longitudinal axis and in fluid communication with the cavity selectively attenuates acoustic energy from the cavity based on the sound pressure level by receiving at least some of the acoustic energy from the cavity and/or the moving element when it is displaced from the cavity.
FILED	Friday, January 12, 2018
APPL NO	15/870372
ART UNIT	2654 — Audio Signals
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 11/08 (20130101) A61F 2011/085 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/162 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/1016 (20130101) H04R 1/1083 (20130101) Original (OR) Class H04R 3/04 (20130101)
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10375659 — Wireless body-area network time synchronization using R peak reference broadcasts

US 10375659	Ramlall
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	SPAWAR Systems Center Pacific (San Diego, California)
ASSIGNEE(S)	The United States of America as represented by Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Rohan Y. Ramlall (Brentwood, California)
ABSTRACT	A WBAN system for real-time telemonitoring health of a subject, involving a wearable biosignal sensors, each sensor of the sensors configured to measure a plurality of biosignals, ultra-low-power radios correspondingly coupled with the sensors; and a processor operable with at least one of the sensors and the radios, each radio of the radios configured to receive the biosignals from each corresponding sensor and to transmit the biosignals to a processor via a WBAN, and the processor configured to: receive the biosignals from the radios, process the biosignals via a set of executable instructions storable in relation to a nontransitory memory device, the set of executable instructions comprising an instruction for synchronizing time of the biosignals by using the broadcasted R peak reference, whereby real-time health data is providable, and transmit the real-time health data to a healthcare provider.
FILED	Thursday, March 30, 2017
APPL NO	15/473828
ART UNIT	2467 — Multiplex and VoIP
CURRENT CPC	Transmission H04B 13/005 (20130101) Wireless Communication Networks H04W 4/70 (20180201) H04W 56/0005 (20130101) Original (OR) Class
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10375838 — Sleeved coaxial printed circuit board vias

US 10375838	Brigham et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Glenn A. Brigham (Chelmsford, Massachusetts); Richard J. Stanley (Moultonborough, New Hampshire); Bradley Thomas Perry (Nashua, New Hampshire); Patrick J. Bell (Arlington, Massachusetts)
ABSTRACT	A printed circuit board, and a method of fabricating the printed circuit board is disclosed. The printed circuit board includes at least one coaxial via. A hollow via is disposed in the printed circuit board. A metal sleeve is formed around the circumference of said hollow via. An inner conductive path is disposed in the hollow via. Additionally, an insulating material is disposed in the hollow via, between the conducting path and the metal sleeve. The conductive path is used to connect signal traces disposed on two different layers of the printed circuit board. In some embodiments, these signal traces carry signals having a frequency above 1 GHz, although the disclosure is not limited to this embodiment.
FILED	Wednesday, March 15, 2017
APPL NO	15/459383
ART UNIT	3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/115 (20130101) H05K 1/116 (20130101) H05K 1/0222 (20130101) H05K 3/42 (20130101) Original (OR) Class H05K 3/0094 (20130101) H05K 3/4685 (20130101) H05K 2201/0959 (20130101) H05K 2201/09745 (20130101) H05K 2201/10242 (20130101) H05K 2203/03 (20130101) H05K 2203/30 (20130101) H05K 2203/0703 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49123 (20150115)
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10375855 — Systems and methods for zero power automatic thermal regulation

US 10375855	Fertig et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	Honeywell International Inc. (Morris Plains, New Jersey)
INVENTOR(S)	Chad Fertig (Bloomington, Minnesota); Karl D. Nelson (Plymouth, Minnesota); Joshua Dorr (Golden Valley, Minnesota); Steven Tin (Plymouth, Minnesota); Neil A Krueger (Saint Paul, Minnesota)
ABSTRACT	Systems and methods for zero power automatic thermal regulation are provided. In one embodiment, a method for passive thermal management comprises: establishing thermal conductivity between a self-heating electronic device and a cooling fluid held within a fluid reservoir via a thermal interface; using thermally controlled expansion of the cooling fluid, controlling a length of a column of the cooling fluid extending into at least one channel extending from the fluid reservoir, wherein the channel provides a non-recirculating path for the cooling fluid to expand into, and wherein the length of a column of the cooling fluid is thermally controlled using heat absorbed by the cooling fluid from the self-heating electronic device; and selectively establishing a primary heat path between the electronic device and a heat sink interface thermally coupled to an external environment as a function of the length of the column of the cooling fluid within the channel.
FILED	Tuesday, January 23, 2018
APPL NO	15/877786
ART UNIT	2835 — Electrical Circuits and Systems
CURRENT CPC	Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2013/008 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/373 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20218 (20130101) H05K 7/20263 (20130101) H05K 7/20272 (20130101) H05K 7/20281 (20130101) Original (OR) Class
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Department of Energy (DOE)

10369229 — Methods and compositions for liposomal formulation of antigens and uses thereof

US 10369229	Fujii et al.
FUNDED BY	Department of Homeland Security (DHS) Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); MOLECULAR EXPRESS, INC. (Rancho Dominquez, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); MOLECULAR EXPRESS, INC. (Rancho Dominguez, California)
INVENTOR(S)	Gary Fujii (Rancho Palos Verdes, California); Francis C. Szoka (San Francisco, California); Douglas S. Watson (Harrisonburg, Virginia)
ABSTRACT	The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
FILED	Monday, April 02, 2018
APPL NO	15/943382
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 39/07 (20130101) A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 39/385 (20130101) A61K 47/543 (20170801) A61K 47/554 (20170801) A61K 47/6911 (20170801) A61K 47/6913 (20170801) Original (OR) Class A61K 2039/60 (20130101) A61K 2039/627 (20130101) A61K 2039/6018 (20130101) A61K 2039/55555 (20130101) A61K 2039/55572 (20130101) Steroids C07J 9/00 (20130101) C07J 41/0055 (20130101) C07J 43/003 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16134 (20130101) C12N 2760/16134 (20130101) C12N 2770/00011 (20130101) C12N 2770/00034 (20130101)
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10369748 — Friction stirring interlocking of dissimilar materials

US 10369748	Whalen et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
INVENTOR(S)	Scott A. Whalen (Richland, Washington); Md. Reza-E-Rabby (Richland, Washington); Kenneth A. Ross (West Richland, Washington); Aashish Rohatgi (Richland, Washington)
ABSTRACT	A method for solid state joining of dissimilar materials using a friction stir welding device wherein a pin is inserted through an aperture defined in a first material and a second material to hold the materials together and then held in place by friction stir welding a portion of the pin to a material adjacent said pin, or by friction stir welding a cap or plug that holds the pin in place to the adjacent material. The result is a connection or join wherein the central portion of the pin is not friction stir welded but the portions holding the pin in place (the ends or caps) generally are.
FILED	Thursday, October 26, 2017
APPL NO	15/794687
ART UNIT	1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Forging; Hammering; Pressing Metal; Riveting; Forge Furnaces B21J 15/027 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 20/127 (20130101) B23K 20/129 (20130101) B23K 2103/15 (20180801) B23K 2103/16 (20180801) B23K 2103/20 (20180801) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 65/0681 (20130101) Original (OR) Class
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10370407 — Affinity-assisted protein modification and recycling

US 10370407	Kwant et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents Of The University Of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Richard L. Kwant (Oakland, California); Matthew B. Francis (Berkeley, California); Christian B. Rosen (Berkeley, California); Meera Rao (San Francisco, California)
ABSTRACT	Methods for preparing a protein conjugate having a defined number of conjugate groups are provided. The method includes: forming a mixture containing a macrocyclic matrix material and a plurality of proteins; eluting the proteins to obtain a first separated protein fraction and a second separated protein fraction, wherein substantially all of the proteins in the first separated protein fraction have the same number of handle moieties; contacting the handle moieties with a conversion reagent under conditions sufficient to convert the handle moieties in the first separated protein fraction to reactive moieties; and contacting the reactive moieties with a conjugation reagent under conditions sufficient to form a plurality of protein conjugates, wherein substantially all of the protein conjugates in the plurality have the same number of conjugate groups. Methods also include recovering enzymes and other proteins from mixtures for isolation and/or reuse of the enzymes and proteins.
FILED	Thursday, January 21, 2016
APPL NO	15/545459
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 1/13 (20130101) C07K 1/1077 (20130101) Original (OR) Class Polysaccharides; Derivatives Thereof C08B 37/0012 (20130101) C08B 37/0015 (20130101) Derivatives of Natural Macromolecular Compounds C08H 1/00 (20130101)
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10370418 — Engineered microorganisms having resistance to ionic liquids

US 10370418	Thelen et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Michael P. Thelen (Danville, California); Douglas A. Higgins (Point Pleasant, New Jersey); Thomas L. Ruegg (Berkeley, California)
ABSTRACT	The present invention provides for a method of genetically modifying microorganisms to enhance resistance to ionic liquids using a yeast Major Facilitator Superfamily (MFS), or a Salmonella MFS SmvA Pump or SmvR Regulator, a Small Multidrug Resistance Family (SMR), or Saccharomyces cerevisiae YDR090C, polypeptide, host cells genetically modified in accordance with the methods, and methods of using the host cells in a reaction comprising biomass that has been pretreated with ionic liquids.
FILED	Wednesday, May 20, 2015
APPL NO	14/717962
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/255 (20130101) Original (OR) Class C07K 14/395 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/16 (20130101) C12N 1/20 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) C12P 2203/00 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/16 (20130101)
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10370483 — Poly(phenylene)-based anion exchange polymers and methods thereof

US 10370483	Kim et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Yu Seung Kim (Los Alamos, New Mexico); Kwan-Soo Lee (Los Alamos, New Mexico); Cy Fujimoto (Albuquerque, New Mexico)
ABSTRACT	The present invention relates to anionic exchange polymers including a poly(phenylene) structure. The structure can include any useful cationic moiety. Methods and uses of such structures and polymers are also described herein. In one instance, such polymers are employed to form a solid membrane.
FILED	Wednesday, July 18, 2018
APPL NO	16/039158
ART UNIT	1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/10 (20130101) Original (OR) Class C08G 2261/11 (20130101) C08G 2261/46 (20130101) C08G 2261/312 (20130101) C08G 2261/516 (20130101) C08G 2261/722 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2256 (20130101) C08J 2365/02 (20130101) Compositions of Macromolecular Compounds C08L 65/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1023 (20130101) H01M 8/1039 (20130101)
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10370577 — Self-repairing cement polymer composites and processes of making and using same

US 10370577	Fernandez et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
INVENTOR(S)	Carlos A. Fernandez (Kennewick, Washington); Phillip K. Koech (Richland, Washington); Wooyong Um (Richland, Washington); Vassiliki-Alexandra Glezakou (Richland, Washington); Jaehun Chun (Richland, Washington); M. Ian Childers (Richland, Washington); Manh Thuong Nguyen (Richland, Washington); Kenton A. Rod (Richland, Washington)
ABSTRACT	New cement-polymer composites and processes of making and using are detailed. One exemplary cement-polymer composite include a Portland cement, an epoxide polymer, a thiol-containing crosslinking agent, and an optional phase separation inhibitor. These composites are dynamically self-healing, mechanically robust, and thermally stable in high temperature environments and can be expected to increase service lifetimes in various applications including energy producing wellbores.
FILED	Tuesday, August 15, 2017
APPL NO	15/677993
ART UNIT	3674 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 24/16 (20130101) C04B 24/16 (20130101) C04B 24/32 (20130101) C04B 24/32 (20130101) C04B 24/281 (20130101) C04B 24/281 (20130101) C04B 28/04 (20130101) C04B 28/04 (20130101) C04B 2103/0062 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/428 (20130101) C09K 8/467 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 33/14 (20130101)
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10370675 — Transgenic plants exhibiting enhanced phytochelatin-based heavy metal tolerance and methods of use thereof

US 10370675	Rea et al.
FUNDED BY	Department of Energy (DOE) Environmental Protection Agency (EPA) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB) Department of Agriculture (USDA)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Washington University in St. Louis (St. Louis, Missouri); Donald Danforth Plant Science Center (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S)	Philip A. Rea (Ardmore, Pennsylvania); Joseph Jez (Kirkwood, Missouri); Rebecca Cahoon (Lincoln, Nebraska)
ABSTRACT	Transgenic plants exhibiting phytochelatin-based heavy metal tolerance and methods of use thereof for bioremediation are disclosed.
FILED	Tuesday, May 23, 2017
APPL NO	15/602757
ART UNIT	1663 — Plants
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/32 (20130101) C02F 2101/20 (20130101) C02F 2103/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/104 (20130101) C12N 15/8271 (20130101) Original (OR) Class Enzymes C12Y 203/02015 (20130101)
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10370686 — Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds

US 10370686	Runguphan et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Weerawat Runguphan (Mueang, Thailand); Jay D. Keasling (Berkeley, California)
ABSTRACT	The present invention provides for a genetically modified yeast host cell capable of producing one or more fatty acids, or fatty acid-derived compounds, or a mixture thereof, comprising: (a) increased expression of acetyl-CoA carboxylase (such as ACC1), (b) increased expression of one or more fatty acid synthases (such as FAS1 and FAS2), and (c) optionally reduced expression of one or more enzymes involved in or in the β-oxidation pathway (such as peroxisomal transporters PXA1 and PXA2, and β-oxidation enzymes POX1, POX2, and POX3).
FILED	Monday, January 25, 2016
APPL NO	15/005719
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) C12N 9/1029 (20130101) C12N 15/81 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) C12P 7/649 (20130101) C12P 7/6409 (20130101) Original (OR) Class C12P 7/6463 (20130101) Enzymes C12Y 203/01085 (20130101) C12Y 604/01002 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/13 (20130101)
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10370752 — Imprinting bulk amorphous alloys at room temperature

US 10370752	Lee et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Ames Laboratory (AL) Federally Funded Research and Development Center (FFRDC) Operated by Iowa State University (IASTATE) at Ames, IA Basic Energy Sciences (BES)
APPLICANT(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
INVENTOR(S)	Min Ha Lee (Incheon, South Korea); Eun Soo Park (Jeonju-si, South Korea); Ryan Timothy Ott (Ames, Iowa); Jürgen Eckert (Dresden, Germany)
ABSTRACT	A technique is disclosed for straining an amorphous alloy at ambient temperature to plastically and homogeneously deform the amorphous alloy, such that at least an exterior surface of the deformed amorphous alloy is substantially free of shear bands. An amorphous alloy may be strained at a rate of less than about 9×10⁻⁵s⁻¹or by multiple passes of cold rolling. A pattern from a die may be imprinted into the amorphous alloy when strained, and the amorphous alloy may be used as a die to plastically strain other materials.
FILED	Thursday, April 07, 2016
APPL NO	15/093536
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Alloys C22C 45/10 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/08 (20130101) C22F 1/186 (20130101) Original (OR) Class
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10370766 — Hybrid photo-electrochemical and photo-voltaic cells

US 10370766	Segev et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Joint Center for Artificial Photosynthesis (JCAP) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California); Technion Israel Institute of Technology (Haifa, Israel)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Gideon Segev (Berkeley, California); Ian D. Sharp (Garching, Germany); Hen Dotan (Richan, Israel); Avner Rothschild (Richan, Israel)
ABSTRACT	This disclosure provides systems, methods, and apparatus related to a hybrid photo-electrochemical and photo-voltaic cell. In one aspect, device includes a substrate comprising a semiconductor, a transparent conductor disposed on the second surface of the substrate, a photoanode disposed on the transparent conductor, an electrolyte in electrical communication with the photoanode, and an electrode in contact with the electrolyte. The substrate is doped with a first n-type dopant. A first area of a first surface of the substrate is heavily doped with a first p-type dopant. A second area of the first surface of the substrate is heavily doped with a second n-type dopant. The second surface of the substrate is heavily doped with a second p-type dopant. The electrode is in electrical contact with the second area. The first area is in electrical contact with the second area through an electrical load.
FILED	Thursday, October 26, 2017
APPL NO	15/794312
ART UNIT	1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/003 (20130101) Original (OR) Class C25B 1/04 (20130101) C25B 9/00 (20130101) C25B 11/0415 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/20 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/04 (20130101) H01L 31/0288 (20130101) H01L 31/0682 (20130101) H01L 31/0687 (20130101) H01L 31/02963 (20130101) H01L 31/03042 (20130101) H01L 31/03046 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/385 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/10 (20141201) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/366 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/135 (20151101)
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10371377 — Pulverized fuel-oxygen burner

US 10371377	Taylor et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	Honeywell International Inc. (Morris Plains, New Jersey)
INVENTOR(S)	Curtis Taylor (Gaston, Indiana); Brad Patterson (Dunkirk, Indiana); Jayson Perdue (New Castle, Indiana)
ABSTRACT	A burner assembly combines oxygen and fuel to produce a flame. The burner assembly includes an oxygen supply tube adapted to receive a stream of oxygen and a solid fuel conduit arranged to extend through the oxygen tube to convey a stream of fluidized, pulverized, solid fuel into a flame chamber. Oxygen flowing through the oxygen supply tube passes generally tangentially through a first set of oxygen-injection holes formed in the solid fuel conduit and off-tangentially from a second set of oxygen-injection holes formed in the solid fuel conduit and then mixes with fluidized, pulverized, solid fuel passing through the solid fuel conduit to create an oxygen-fuel mixture in a downstream portion of the solid fuel conduit. This mixture is discharged into a flame chamber and ignited in the flame chamber to produce a flame.
FILED	Thursday, August 17, 2017
APPL NO	15/679944
ART UNIT	3762 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Methods or apparatus for combustion using fluid fuel or Solid Fuel Suspended In Air F23C 6/045 (20130101) F23C 2201/20 (20130101) Burners F23D 1/00 (20130101) F23D 2201/00 (20130101) F23D 2201/20 (20130101) F23D 2900/00006 (20130101) Supplying Air or Non-combustible Liquids or Gases to Combustion Apparatus in General; Valves or Dampers Specially Adapted for Controlling Air Supply or Draught in Combustion Apparatus; Inducing Draught in Combustion Apparatus; Tops for Chimneys or Ventilating Shafts; Terminals for Flues F23L 7/007 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 20/344 (20130101)
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10371416 — Spectrally selective coatings for optical surfaces

US 10371416	Jin et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Sungho Jin (San Diego, California); Renkun Chen (San Diego, California); Zhaowei Liu (San Diego, California); Tae Kyoung Kim (La Jolla, California)
ABSTRACT	Techniques, systems, devices and materials are disclosed for spectrally selective coatings for optical surfaces having high solar absorptivity, low infrared emissivity, and strong durability at elevated temperatures. In one aspect, a spectrally selective coating includes a substrate formed of a light absorbing material, and a composite material formed over the substrate and including nanoparticles dispersed in a dielectric material, in which the composite material forms a coating capable of absorbing solar energy in a selected spectrum and reflecting the solar energy in another selected spectrum.
FILED	Monday, May 06, 2013
APPL NO	14/398722
ART UNIT	2872 — Optics
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 5/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 10/70 (20180501) F24S 20/20 (20180501) F24S 70/20 (20180501) F24S 70/25 (20180501) F24S 70/30 (20180501) F24S 70/60 (20180501) F24S 70/225 (20180501) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) G02B 1/14 (20150115) G02B 1/118 (20130101) G02B 5/003 (20130101) G02B 5/22 (20130101) G02B 5/206 (20130101) G02B 5/207 (20130101) G02B 5/208 (20130101) G02B 2207/101 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/44 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2438 (20150115) Y10T 428/24372 (20150115) Y10T 428/24388 (20150115) Y10T 428/24413 (20150115) Y10T 428/24421 (20150115) Y10T 428/24893 (20150115) Y10T 428/24909 (20150115)
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10371445 — Passive thermal control of microwave furnace components

US 10371445	Ripley
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) National Security Complex and PANTEX Plant (Y-12) NNSA Critical Mission Site Operated by Consolidated Nuclear Security, LLC at Oak Ridge, TN (CNS)
APPLICANT(S)	Consolidated Nuclear Security, LLC (Reston, Virginia)
ASSIGNEE(S)	Consolidated Nuclear Security, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Edward B. Ripley (Knoxville, Tennessee)
ABSTRACT	A microwave furnace includes a microwave casket having an inner surface forming an internal cavity. A heatable body, formed at least in part of a microwave susceptor material, is located in the internal cavity of the casket and heats in response to a microwave field. A thermal control system is provided, which includes a fluid flow path extending through the casket and has an inlet and an outlet formed in the microwave casket. A portion of the fluid flow path is adjacent the heatable body. The thermal control system flows a thermal transfer fluid through the fluid flow path via the inlet to absorb heat from the heatable body and to transfer the absorbed heat along the fluid flow path until the thermal transfer fluid exits the fluid flow path via the outlet.
FILED	Tuesday, November 15, 2016
APPL NO	15/351710
ART UNIT	3761 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Furnaces, Kilns, Ovens, or Retorts in General; Open Sintering or Like Apparatus F27B 14/06 (20130101) Original (OR) Class F27B 14/10 (20130101) F27B 14/20 (20130101) Details or Accessories of Furnaces, Kilns, Ovens, or Retorts, in so Far as They Are of Kinds Occurring in More Than One Kind of Furnace F27D 2099/0028 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/80 (20130101)
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10371580 — Method and apparatus for wavefront sensing

US 10371580	Bahk
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	RAM Photonics, LLC (San Diego, California)
ASSIGNEE(S)	RAM PHOTONICS, LLC (San Diego, California)
INVENTOR(S)	Seung-Whan Bahk (Rochester, New York)
ABSTRACT	A method for performing optical wavefront sensing includes providing an amplitude transmission mask having a light input side, a light output side, and an optical transmission axis passing from the light input side to the light output side. The amplitude transmission mask is characterized by a checkerboard pattern having a square unit cell of size Λ. The method also includes directing an incident light field having a wavelength λ to be incident on the light input side and propagating the incident light field through the amplitude transmission mask. The method further includes producing a plurality of diffracted light fields on the light output side and detecting, at a detector disposed a distance L from the amplitude transmission mask, an interferogram associated with the plurality of diffracted light fields. The relation $0 < L < \frac{1}{8} \frac{Λ^{2}}{λ} or \frac{1}{4} \frac{Λ^{2}}{λ} (2 n - 1) < L < \frac{1}{4} \frac{Λ^{2}}{λ} (2 n + 1)$ is satisfied, where n is an integer greater than zero.
FILED	Friday, February 23, 2018
APPL NO	15/903489
ART UNIT	2886 — Optics
CURRENT CPC	Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 9/02 (20130101) G01J 9/0215 (20130101) Original (OR) Class G01J 2009/002 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/706 (20130101)
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10371598 — High sensitivity bearing tester and systems thereof

US 10371598	Nation et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandis, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Brendan L. Nation (Albuquerque, New Mexico); Michael T. Dugger (Tijeras, New Mexico); Rand Garfield (Corrales, New Mexico)
ABSTRACT	The present invention relates to an apparatus for testing a bearing, as well as systems including such an apparatus. In one instance, the apparatus allows for torsional losses of a bearing to be determined in a highly sensitive manner. Results can be determined in a controlled environment, as the system can include an environmental enclosure to encapsulate the testing apparatus.
FILED	Tuesday, July 25, 2017
APPL NO	15/659479
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 5/0009 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 13/04 (20130101) Original (OR) Class
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10371668 — Apparatus and methods for probing a material as a function of depth using depth-dependent second harmonic generation

US 10371668	Garnett et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Energy (DOE)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee)
INVENTOR(S)	Joy Garnett (Nashville, Tennessee); Halina Krzyzanowska (Nashville, Tennessee); Norman H. Tolk (Brentwood, Tennessee)
ABSTRACT	A method for non-invasively probing at least one physics property of a solid material. In one embodiment, the method has the steps of splitting a photon beam into a first photon beam and a second photon beam, exposing the solid material to the first photon beam to generate a coherent acoustic phonon wave in the solid material at time t, and exposing the solid material to the second photon beam at a time t+Δt, where t+Δt≥t, to generate corresponding second harmonic generation signals, where from the corresponding second harmonic generation signals, the at least one physics property of the solid material is determinable.
FILED	Monday, July 13, 2015
APPL NO	15/324100
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/636 (20130101) G01N 21/8422 (20130101) G01N 21/9505 (20130101) G01N 29/043 (20130101) G01N 29/2418 (20130101) Original (OR) Class G01N 29/4454 (20130101) G01N 2021/8438 (20130101) G01N 2021/8477 (20130101)
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10371681 — Systems and methods for generation of hydrogen peroxide vapor

US 10371681	Love et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Adam H. Love (Berkeley, California); Joel Del Eckels (Livermore, California); Alex K. Vu (Dublin, California); Armando Alcaraz (Livermore, California); John G. Reynolds (San Ramon, California)
ABSTRACT	A method according one embodiment includes at least one of bubbling dried air through a hydrogen peroxide solution in a container for producing a first hydrogen peroxide vapor, and passing dried air from the moisture trap into a headspace above the hydrogen peroxide solution in a container for producing a second hydrogen peroxide vapor. Additional systems and methods are also presented.
FILED	Monday, December 01, 2014
APPL NO	14/557350
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 15/01 (20130101) C01B 15/013 (20130101) Pipe-line Systems; Pipe-lines F17D 1/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/007 (20130101) Original (OR) Class G01N 2033/0072 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401)
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10371689 — Ultra-compact system for characterization of physical, chemical and ignition properties of fuels

US 10371689	Mcnenly et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Matthew J. Mcnenly (Oakland, California); Geoffrey M. Oxberry (Pleasanton, California); Ahmed E. Ismail (Aachen, Germany); Nicholas Killingsworth (Pleasanton, California); Daniel L. Flowers (San Leandro, California)
ABSTRACT	The present disclosure relates to a miniaturized fuel laboratory system having exterior dimensions enabling the system to be at least one of hand-holdable or contained on a component. The system makes use of a processor, a fuel inlet port for receiving a quantity of fuel to be used as a fuel test sample, and at least one fuel sensor in communication with the fuel inlet port for receiving the fuel test sample. The processor uses the information obtained by the fuel sensor to determine at least one characteristic of the fuel test sample.
FILED	Friday, September 09, 2016
APPL NO	15/261304
ART UNIT	2862 — Printing/Measuring and Testing
CURRENT CPC	Controlling Combustion Engines F02D 19/0626 (20130101) F02D 19/0649 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 17/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/2817 (20130101) Original (OR) Class Electric Digital Data Processing G06F 17/14 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/36 (20130101)
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10371729 — Real-time estimation of solar irradiation

US 10371729	Dang et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Hien P. Dang (Nanuet, New York); Sri M. Sri-Jayantha (Ossining, New York)
ABSTRACT	Aspects relate to methods, systems, and computer program products for estimating future levels of solar power received at a sensor including receiving, by a processor, a first measured power value at a first time from the sensor, calculating a first value of a dynamic correction factor based on the first measured power value associated with the first time, applying the first value of the calculated dynamic correction factor to a power estimation model, generating a first power estimation value for a second time using the power estimation model, wherein the second time is later than the first time, receiving a second measured power value at the second time, and calculating a second value of a dynamic correction factor based on the second measured power value associated with the second time and the first value of the dynamic correction factor.
FILED	Thursday, January 21, 2016
APPL NO	15/003202
ART UNIT	2825 — Semiconductors/Memory
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) G01J 2001/4266 (20130101) G01J 2001/4276 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 21/133 (20130101) Original (OR) Class
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10371740 — Power system disturbance localization using recurrence quantification analysis and minimum-volume-enclosing ellipsoid

US 10371740	Cui et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
INVENTOR(S)	Yi Cui (Knoxville, Tennessee); Feifei Bai (Macgregor, Australia); Wenxuan Yao (Knoxville, Tennessee); Yong Liu (Knoxville, Tennessee); Ling Wu (Knoxville, Tennessee); Yilu Liu (Knoxville, Tennessee)
ABSTRACT	A method for determining a location of a disturbance in a power system is provided. The method includes receiving data from a plurality of sensors distributed across the power system; performing a recurrence quantification analysis on the received data to identify a predetermined number of sensors, from the plurality of sensors, that are closest to the disturbance; constructing a plurality of minimum-volume-enclosing ellipsoids based on and enclosing the data received from the identified sensors; extracting one or more parameters from the plurality of minimum-volume-enclosing ellipsoids; inputting the one or more parameters into a multivariate-random-forest regression algorithm to determine the location of the disturbance and a power mismatch corresponding to the disturbance; and presenting, on one or more display units, the determined location of the disturbance and the determined power mismatch.
FILED	Wednesday, May 31, 2017
APPL NO	15/609861
ART UNIT	2862 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 31/086 (20130101) Original (OR) Class G01R 31/088 (20130101) Systems for Regulating Electric or Magnetic Variables G05F 1/66 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101) Emergency Protective Circuit Arrangements H02H 1/0092 (20130101)
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10372148 — Power system disturbance location determination based on rate of change of frequency

US 10372148	You et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
INVENTOR(S)	Shutang You (Knoxville, Texas); Dao Zhou (Knoxville, Tennessee); Ling Wu (Knoxville, Tennessee); Yilu Liu (Knoxville, Tennessee)
ABSTRACT	A method for determining a location of a disturbance in a power system is provided. The method includes receiving data from a plurality of sensors distributed across the power system; determining, with one or more processors, for each sensor, an extremum of the data corresponding to the sensor; interpolating, with the one or more processors, the extrema; and presenting, on one or more display units, a location corresponding to a global maximum of the interpolated extrema as the location of the disturbance. The method may further include, if a difference between the largest extremum and each of remaining extremum is greater than a predetermined threshold, skipping the interpolating step and the presenting step, and presenting a location of the sensor corresponding to the largest extremum as the location of the disturbance.
FILED	Wednesday, November 16, 2016
APPL NO	15/353341
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/048 (20130101) G05B 2219/31356 (20130101) Systems for Regulating Electric or Magnetic Variables G05F 1/66 (20130101) Original (OR) Class
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10373703 — Scar-less multi-part DNA assembly design automation

US 10373703	Hillson
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Nathan J. Hillson (San Francisco, California)
ABSTRACT	The present invention provides a method of a method of designing an implementation of a DNA assembly. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding flanking homology sequences to each of the DNA oligos. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding optimized overhang sequences to each of the DNA oligos.
FILED	Thursday, May 05, 2016
APPL NO	15/147764
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Original (OR) Class G16B 20/00 (20190201) G16B 25/00 (20190201) G16B 30/00 (20190201)
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10373755 — High voltage transformer

US 10373755	Prager et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	EAGLE HARBOR TECHNOLOGIES, INC. (Seattle, Washington)
ASSIGNEE(S)	EAGLE HARBOR TECHNOLOGIES, INC. (Seattle, Washington)
INVENTOR(S)	James R. Prager (Seattle, Washington); Timothy M. Ziemba (Bainbridge Island, Washington); Kenneth E. Miller (Seattle, Washington); John G. Carscadden (Seattle, Washington); Ilia Slobodov (Seattle, Washington)
ABSTRACT	A high-voltage transformer is disclosed. The high-voltage transformer includes a transformer core; at least one primary winding wound once or less than once around the transformer core; a secondary winding wound around the transformer core a plurality of times; an input electrically coupled with the primary windings; and an output electrically coupled with the secondary windings that provides a voltage greater than 1,1200 volts. In some embodiments, the high-voltage transformer has a stray inductance of less than 30 nH as measured on the primary side and the transformer has a stray capacitance of less than 100 pF as measured on the secondary side.
FILED	Wednesday, November 30, 2016
APPL NO	15/365094
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/24 (20130101) H01F 27/2804 (20130101) H01F 27/2866 (20130101) H01F 27/2895 (20130101) H01F 30/16 (20130101) Original (OR) Class H01F 2027/2814 (20130101)
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10373815 — Methods of resolving artifacts in Hadamard-transformed data

US 10373815	Crowell et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Kevin L. Crowell (Richland, Washington); Spencer A. Prost (Richland, Washington)
ABSTRACT	A method of validating data produced from a multiplexing process on an analytical instrument is disclosed. In one embodiment, the method includes using a pseudorandom sequence to encode a multiplexed segment of data; applying Hadamard transform to generate a demultiplexed segment of the data; aligning the pseudorandom sequence to the multiplexed data; and calculating a score for at least one positive value in the demultiplexed segment to find a valid demultiplexed value.
FILED	Wednesday, March 05, 2014
APPL NO	14/197930
ART UNIT	2864 — Printing/Measuring and Testing
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/0036 (20130101) Original (OR) Class
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10374072 — Methods and devices for fabricating and assembling printable semiconductor elements

US 10374072	Nuzzo et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of Energy (DOE) Office of Science (DOE-SC) Materials Sciences and Engineering Division (MSE)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Ralph G. Nuzzo (Champaign, Illinois); John A. Rogers (Champaign, Illinois); Etienne Menard (Voglans, France); Keon Jae Lee (Daejeon, South Korea); Dahl-Young Khang (Seoul, South Korea); Yugang Sun (Gladwyne, Pennsylvania); Matthew Meitl (Durham, North Carolina); Zhengtao Zhu (Rapid City, South Dakota)
ABSTRACT	The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.
FILED	Friday, June 30, 2017
APPL NO	15/640206
ART UNIT	2829 — Semiconductors/Memory
CURRENT CPC	Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 2201/0185 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/308 (20130101) H01L 21/322 (20130101) H01L 21/02521 (20130101) H01L 21/02603 (20130101) H01L 21/02628 (20130101) H01L 21/6835 (20130101) H01L 23/02 (20130101) H01L 24/03 (20130101) H01L 24/05 (20130101) H01L 24/08 (20130101) H01L 24/29 (20130101) H01L 24/32 (20130101) H01L 24/80 (20130101) H01L 24/83 (20130101) H01L 24/94 (20130101) H01L 24/97 (20130101) H01L 25/0753 (20130101) H01L 27/1285 (20130101) H01L 27/1292 (20130101) H01L 29/04 (20130101) H01L 29/06 (20130101) H01L 29/12 (20130101) H01L 29/068 (20130101) H01L 29/76 (20130101) Original (OR) Class H01L 29/0665 (20130101) H01L 29/0673 (20130101) H01L 29/0676 (20130101) H01L 29/78603 (20130101) H01L 29/78681 (20130101) H01L 29/78696 (20130101) H01L 31/0392 (20130101) H01L 31/1804 (20130101) H01L 31/1864 (20130101) H01L 31/1896 (20130101) H01L 31/03926 (20130101) H01L 33/007 (20130101) H01L 33/32 (20130101) H01L 33/0079 (20130101) H01L 2221/68368 (20130101) H01L 2221/68381 (20130101) H01L 2224/03 (20130101) H01L 2224/03 (20130101) H01L 2224/03 (20130101) H01L 2224/80 (20130101) H01L 2224/80 (20130101) H01L 2224/83 (20130101) H01L 2224/83 (20130101) H01L 2224/94 (20130101) H01L 2224/94 (20130101) H01L 2224/95 (20130101) H01L 2224/97 (20130101) H01L 2224/97 (20130101) H01L 2224/97 (20130101) H01L 2224/0332 (20130101) H01L 2224/0332 (20130101) H01L 2224/0345 (20130101) H01L 2224/0362 (20130101) H01L 2224/2919 (20130101) H01L 2224/2919 (20130101) H01L 2224/03614 (20130101) H01L 2224/05073 (20130101) H01L 2224/05073 (20130101) H01L 2224/05082 (20130101) H01L 2224/05082 (20130101) H01L 2224/05124 (20130101) H01L 2224/05124 (20130101) H01L 2224/05144 (20130101) H01L 2224/05144 (20130101) H01L 2224/05144 (20130101) H01L 2224/05155 (20130101) H01L 2224/05155 (20130101) H01L 2224/05155 (20130101) H01L 2224/05166 (20130101) H01L 2224/05166 (20130101) H01L 2224/05166 (20130101) H01L 2224/05552 (20130101) H01L 2224/05552 (20130101) H01L 2224/05553 (20130101) H01L 2224/05553 (20130101) H01L 2224/05554 (20130101) H01L 2224/05554 (20130101) H01L 2224/05555 (20130101) H01L 2224/05555 (20130101) H01L 2224/05644 (20130101) H01L 2224/05644 (20130101) H01L 2224/05644 (20130101) H01L 2224/05644 (20130101) H01L 2224/05666 (20130101) H01L 2224/05666 (20130101) H01L 2224/08225 (20130101) H01L 2224/8385 (20130101) H01L 2224/9202 (20130101) H01L 2224/9202 (20130101) H01L 2224/32225 (20130101) H01L 2224/32225 (20130101) H01L 2224/80006 (20130101) H01L 2224/80121 (20130101) H01L 2224/80121 (20130101) H01L 2224/80862 (20130101) H01L 2224/80895 (20130101) H01L 2224/83005 (20130101) H01L 2224/83121 (20130101) H01L 2224/83121 (20130101) H01L 2224/83192 (20130101) H01L 2224/83192 (20130101) H01L 2224/83193 (20130101) H01L 2224/83862 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00012 (20130101) H01L 2924/00012 (20130101) H01L 2924/00012 (20130101) H01L 2924/00012 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/00014 (20130101) H01L 2924/14 (20130101) H01L 2924/14 (20130101) H01L 2924/0665 (20130101) H01L 2924/0665 (20130101) H01L 2924/01032 (20130101) H01L 2924/01032 (20130101) H01L 2924/01032 (20130101) H01L 2924/1305 (20130101) H01L 2924/1305 (20130101) H01L 2924/1306 (20130101) H01L 2924/1306 (20130101) H01L 2924/1461 (20130101) H01L 2924/1461 (20130101) H01L 2924/1579 (20130101) H01L 2924/10253 (20130101) H01L 2924/10329 (20130101) H01L 2924/12032 (20130101) H01L 2924/12032 (20130101) H01L 2924/12036 (20130101) H01L 2924/12036 (20130101) H01L 2924/12041 (20130101) H01L 2924/12042 (20130101) H01L 2924/12042 (20130101) H01L 2924/12043 (20130101) H01L 2924/12043 (20130101) H01L 2924/12044 (20130101) H01L 2924/12044 (20130101) H01L 2924/13063 (20130101) H01L 2924/13063 (20130101) H01L 2924/13091 (20130101) H01L 2924/13091 (20130101) H01L 2924/15159 (20130101) H01L 2924/15162 (20130101) H01L 2924/15788 (20130101) H01L 2924/15788 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/547 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/521 (20151101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/707 (20130101) Y10S 977/724 (20130101)
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10374109 — Silicon-based visible and near-infrared optoelectric devices

US 10374109	Mazur et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	President And Fellows Of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Eric Mazur (Concord, Massachusetts); James Edward Carey (Ann Arbor, Michigan)
ABSTRACT	In one aspect, the present invention provides a silicon photodetector having a surface layer that is doped with sulfur inclusions with an average concentration in a range of about 0.5 atom percent to about 1.5 atom percent. The surface layer forms a diode junction with an underlying portion of the substrate. A plurality of electrical contacts allow application of a reverse bias voltage to the junction in order to facilitate generation of an electrical signal, e.g., a photocurrent, in response to irradiation of the surface layer. The photodetector exhibits a responsivity greater than about 1 A/W for incident wavelengths in a range of about 250 nm to about 1050 nm, and a responsivity greater than about 0.1 A/W for longer wavelengths, e.g., up to about 3.5 microns.
FILED	Monday, October 16, 2017
APPL NO	15/784756
ART UNIT	2893 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/268 (20130101) H01L 21/02532 (20130101) H01L 21/02686 (20130101) H01L 31/028 (20130101) H01L 31/036 (20130101) H01L 31/068 (20130101) H01L 31/0236 (20130101) H01L 31/0288 (20130101) H01L 31/1804 (20130101) H01L 31/1864 (20130101) H01L 31/1872 (20130101) H01L 31/02363 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/52 (20130101) Y02E 10/547 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/521 (20151101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 438/94 (20130101)
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10374234 — Current collectors for improved safety

US 10374234	Abdelmalak et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-BATTELLE LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Michael Naguib Abdelmalak (Knoxville, Tennessee); Srikanth Allu (Oak Ridge, Tennessee); Nancy J. Dudney (Knoxville, Tennessee); Jianlin Li (Knoxville, Tennessee); Srdjan Simunovic (Knoxville, Tennessee); Hsin Wang (Knoxville, Tennessee)
ABSTRACT	A battery electrode assembly includes a current collector with conduction barrier regions having a conductive state in which electrical conductivity through the conduction barrier region is permitted, and a safety state in which electrical conductivity through the conduction barrier regions is reduced. The conduction barrier regions change from the conductive state to the safety state when the current collector receives a short-threatening event. An electrode material can be connected to the current collector. The conduction barrier regions can define electrical isolation subregions. A battery is also disclosed, and methods for making the electrode assembly, methods for making a battery, and methods for operating a battery.
FILED	Friday, November 10, 2017
APPL NO	15/809650
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/70 (20130101) Original (OR) Class H01M 4/661 (20130101) H01M 4/667 (20130101) H01M 10/0525 (20130101) H01M 10/4235 (20130101) H01M 2004/027 (20130101) H01M 2004/028 (20130101)
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10374236 — Metal-air cell with performance enhancing additive

US 10374236	Friesen et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Arizona Board of Regents Acting For And on Behalf of Arizona State University (Tempe, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (Tempe, Arizona)
INVENTOR(S)	Cody A. Friesen (Fort McDowell, Arizona); Daniel Buttry (Tempe, Arizona)
ABSTRACT	Systems and methods drawn to an electrochemical cell comprising a low temperature ionic liquid comprising positive ions and negative ions and a performance enhancing additive added to the low temperature ionic liquid. The additive dissolves in the ionic liquid to form cations, which are coordinated with one or more negative ions forming ion complexes. The electrochemical cell also includes an air electrode configured to absorb and reduce oxygen. The ion complexes improve oxygen reduction thermodynamics and/or kinetics relative to the ionic liquid without the additive.
FILED	Wednesday, September 23, 2015
APPL NO	14/862376
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/86 (20130101) H01M 4/90 (20130101) H01M 8/02 (20130101) Original (OR) Class H01M 12/06 (20130101) H01M 12/08 (20130101) H01M 2300/0022 (20130101) H01M 2300/0025 (20130101) H01M 2300/0045 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/128 (20130101)
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10374239 — Aqueous pyridinium cation-based redox flow batteries

US 10374239	Zhang et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S)	Zhengcheng Zhang (Naperville, Illinois); Jinhua Huang (Willowbrook, Illinois); Kevin Gallagher (Downers Grove, Illinois)
ABSTRACT	The present invention provides an aqueous redox flow battery comprising a negative electrode immersed in an aqueous liquid negative electrolyte, a positive electrode immersed in an aqueous liquid positive electrolyte, and a cation-permeable separator (e.g., a porous membrane, film, sheet, or panel) between the negative electrolyte from the positive electrolyte. During charging and discharging, the electrolytes are circulated over their respective electrodes. The electrolytes each comprise an electrolyte salt (e.g., a lithium or sodium salt), a redox reactant. The negative redox reactant comprises a pyridinium compound of Formula (I) as described in the specification.
FILED	Thursday, December 29, 2016
APPL NO	15/394031
ART UNIT	1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/90 (20130101) H01M 8/188 (20130101) H01M 8/04186 (20130101) H01M 8/04201 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/528 (20130101)
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10374261 — High efficiency iron electrode and additives for use in rechargeable iron-based batteries

US 10374261	Narayan et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S)	University of Southern California (Los Angeles, California)
INVENTOR(S)	Sri R. Narayan (Arcadia, California); G. K. Surya Prakash (Hacienda Heights, California); Robert Aniszfeld (Los Angeles, California); Aswin Manohar (Los Angeles, California); Souradip Malkhandi (Los Angeles, California); Bo Yang (Los Angeles, California)
ABSTRACT	An iron electrode and a method of manufacturing an iron electrode for use in an iron-based rechargeable battery are disclosed. In one embodiment, the iron electrode includes carbonyl iron powder and one of a metal sulfide additive or metal oxide additive selected from the group of metals consisting of bismuth, lead, mercury, indium, gallium, and tin for suppressing hydrogen evolution at the iron electrode during charging of the iron-based rechargeable battery. An iron-air rechargeable battery including an iron electrode comprising carbonyl iron is also disclosed, as is an iron-air battery wherein at least one of the iron electrode and the electrolyte includes an organosulfur additive.
FILED	Tuesday, November 22, 2016
APPL NO	15/358291
ART UNIT	1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/12 (20130101) H01M 4/38 (20130101) H01M 4/62 (20130101) H01M 4/364 (20130101) H01M 4/366 (20130101) H01M 4/622 (20130101) H01M 10/26 (20130101) H01M 10/30 (20130101) Original (OR) Class H01M 10/4235 (20130101) H01M 12/08 (20130101) H01M 12/065 (20130101) H01M 2004/021 (20130101) H01M 2220/10 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/128 (20130101)
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10374262 — Protective cathode coatings for lithium-ion batteries

US 10374262	Aykol et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	Muratahan Aykol (Moraga, California); Soo Kim (Skokie, Illinois); Shiqiang Hao (Glenview, Illinois); Zhi Lu (Evanston, Illinois); Vinay Ishwar Hegde (Chicago, Illinois); David H. Snydacker (Evanston, Illinois); Scott J. Kirklin (Evanston, Illinois); Dane Morgan (Middleton, Wisconsin); Christopher M. Wolverton (Evanston, Illinois)
ABSTRACT	Cathode coatings for lithium ion batteries, cathodes coated with the coatings, and lithium ion batteries incorporating the coated cathodes are provided. The coatings, which are composed of binary, ternary, and higher order metal oxides and/or metalloid oxides, can reduce the hydrofluoric acid (HF)-induced degradation of the electrolyte and/or cathodes, thereby improving the performance of lithium ion batteries, relative to lithium ion batteries that employ bare cathodes.
FILED	Wednesday, February 08, 2017
APPL NO	15/427295
ART UNIT	1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 10/4235 (20130101) Original (OR) Class
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10374385 — Hybrid silicon lasers and amplifiers with 2D phosphorene film

US 10374385	Husko et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois); NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois); NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad Husko (Wauconda, Illinois); Jeff Guest (Lemont, Illinois); Mark Hersam (Evanston, Illinois); Joohoon Kang (Evanston, Illinois); Joshua Wood (Evanston, Illinois); Xavier Checoury (Rue Andre Ampere, France)
ABSTRACT	Hybrid silicon lasers and amplifiers having resonator cavities within a silicon substrate and a two-dimensional material film on the substrate as an optical gain medium are described. The two-dimensional material film may be formed of one or more atomic layers of phosphorene (BP). The number of phosphorene layers may be adjusted to tune the emission wavelength of the hybrid devices.
FILED	Friday, September 15, 2017
APPL NO	15/706109
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/12 (20130101) H01S 5/021 (20130101) Original (OR) Class H01S 5/041 (20130101) H01S 5/50 (20130101) H01S 5/105 (20130101) H01S 5/125 (20130101) H01S 5/0425 (20130101) H01S 5/1042 (20130101) H01S 5/2054 (20130101)
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10374430 — Controller for a customized electric power storage device in a collective microgrid

US 10374430	Wilson et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	David G. Wilson (Tijeras, New Mexico); Rush D. Robinett, III (Tijeras, New Mexico); Steven Y. Goldsmith (Rochester, Minnesota)
ABSTRACT	A controller for an electric power storage device is described herein, wherein the electric power storage device is included in a microgrid. The electric power storage device has at least one of a charge rate, a discharge rate, or a power retention capacity that has been customized for a collective microgrid. The at least one of the charge rate, the discharge rate, or the power retention capacity of the electric power storage device is computed based at least in part upon specified power source parameters in the at least two connected microgrids and specified load parameters in the at least two connected microgrids.
FILED	Friday, January 08, 2016
APPL NO	14/991277
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/382 (20130101) Original (OR) Class H02J 7/34 (20130101) H02J 2003/007 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/76 (20130101)
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10374551 — Subcritical-voltage magnetron RF power source

US 10374551	Kazakevich et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Small Business Administration (SBA) Small Business Technology Transfer (STTR)
APPLICANT(S)	Muons, Inc. (Batavia, Illinois)
ASSIGNEE(S)	Muons, Inc. (Batavia, Illinois)
INVENTOR(S)	Grigory M. Kazakevich (North Aurora, Illinois); Michael L. Neubauer (San Francisco, California); Valeri A. Lebedev (Wheaton, Illinois); Vyacheslav P. Yakovlev (Batavia, Illinois)
ABSTRACT	A system and method of operating a magnetron power source can achieve a broad range of output power control by operating a magnetron with its cathode voltage lower than that needed for free running oscillations (e.g., below the Kapitsa critical voltage or equivalently below the Hartree voltage) A sufficiently strong injection-locking signal enables the output power to be coherently generated and to be controlled over a broad power range by small changes in the cathode voltage. In one embodiment, the present system and method is used for a practical, single, frequency-locked 2-magnetron system design.
FILED	Sunday, February 12, 2017
APPL NO	15/430497
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 9/10 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/02 (20130101) H05H 2007/025 (20130101)
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10375095 — Modeling behavior in a network using event logs

US 10375095	Turcotte et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Triad National Security, LLC (Los Alamos, New Mexico); IP2IPO Innovations Limited (London, United Kingdom)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico); IP2IPO Innovations Limited (London, United Kingdom)
INVENTOR(S)	Melissa J. M. Turcotte (Los Alamos, New Mexico); Nicholas A. Heard (Kent, United Kingdom); Alexander D. Kent (Los Alamos, New Mexico)
ABSTRACT	A framework is provided for modeling the activity surrounding user credentials and/or machine level activity on a computer network using computer event logs by viewing the logs attributed to each user as a multivariate data stream. The methodology performs well in detecting compromised user credentials at a very low false positive rate. Such a methodology may detect both users of compromised credentials by external actors and otherwise authorized users who have begun engaging in malicious activity.
FILED	Friday, November 18, 2016
APPL NO	15/355142
ART UNIT	2431 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1425 (20130101) Original (OR) Class H04L 67/42 (20130101)
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10375106 — Backplane filtering and firewalls

US 10375106	Roesler et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Alexander Roesler (Sandia Park, New Mexico); Abraham Anthony Clements (Lafayette, Indiana); Jason Hamlet (Albuquerque, New Mexico); John Mulder (Albuquerque, New Mexico)
ABSTRACT	Described herein are various technologies for providing active mitigation of cyber-attacks against industrial and other control systems. A filtering device is connected to a backplane of a control system and receives communications from various modules of the control system. The filter device analyzes the received communications and determines whether they are genuine and permissible communications for the control system. Validated signals are output to a communications bus of the control system by the filter device, while impermissible communications are blocked. The filter device can be interposed between the modules of the control system and the backplane, or the filter device can be included as a component of a control system backplane.
FILED	Tuesday, November 29, 2016
APPL NO	15/364011
ART UNIT	2494 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/57 (20130101) G06F 21/70 (20130101) G06F 21/71 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/0245 (20130101) H04L 63/1433 (20130101) H04L 63/1441 (20130101) Original (OR) Class
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10375164 — Parallel storage system with burst buffer appliance for storage of partitioned key-value store across a plurality of storage tiers

US 10375164	Bent et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	EMC Corporation (Hopkinton, Massachusetts)
ASSIGNEE(S)	EMC Corporation (Hopkinton, Massachusetts); Triad National Security, LLC (Los Alamos, New Mexico); UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	John M. Bent (Los Alamos, New Mexico); Sorin Faibish (Newton, Massachusetts); Gary Grider (Los Alamos, New Mexico); Aaron Torres (Los Alamos, New Mexico); Stephen W. Poole (Knoxville, Tennessee)
ABSTRACT	Parallel storage systems are provided with a burst buffer appliance for storage of a partitioned key-value store across a plurality of storage tiers. The burst buffer appliance is configured to store key-value data on first and second storage tiers comprising respective disjoint subsets of storage. One or more servers in the partitioned key-value store provide (i) an interface between one or more local key-value stores and one or more additional storage architectures, and/or (ii) a key value interface that provides access to at least one hardware key-value store. The local key-values are optionally sorted both locally by the local store and globally by the overall MDHIM framework. The local and global sorting can be leveraged to provide batch input/output (IO) operations that aggregate multiple requests into batch operations on one or more sorted ranges.
FILED	Monday, December 30, 2013
APPL NO	14/143749
ART UNIT	2459 — Computer Networks
CURRENT CPC	Electric Digital Data Processing G06F 9/5077 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/1097 (20130101) Original (OR) Class
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10375327 — Mobile gas and chemical imaging camera

US 10375327	Kester
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	REBELLION PHOTONICS, INC. (Houston, Texas)
ASSIGNEE(S)	Rebellion Photonics, Inc. (Houston, Texas)
INVENTOR(S)	Robert Timothy Kester (Friendswood, Texas)
ABSTRACT	In one embodiment, an infrared (IR) imaging system for determining a concentration of a target species in an object is disclosed. The imaging system can include an optical system including an optical focal plane array (FPA) unit. The optical system can have components defining at least two optical channels thereof, said at least two optical channels being spatially and spectrally different from one another. Each of the at least two optical channels can be positioned to transfer IR radiation incident on the optical system towards the optical FPA. The system can include a processing unit containing a processor that can be configured to acquire multispectral optical data representing said target species from the IR radiation received at the optical FPA. Said optical system and said processing unit can be contained together in a data acquisition and processing module configured to be worn or carried by a person.
FILED	Friday, October 20, 2017
APPL NO	15/789811
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/02 (20130101) G01J 3/28 (20130101) G01J 3/0232 (20130101) G01J 3/0256 (20130101) G01J 3/2803 (20130101) G01J 5/02 (20130101) G01J 5/0014 (20130101) G01J 5/0834 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3504 (20130101) Optical Elements, Systems, or Apparatus G02B 5/201 (20130101) G02B 5/208 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/209 (20130101) G06K 9/00624 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) Original (OR) Class H04N 5/2258 (20130101)
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National Science Foundation (NSF)

10369017 — Position/weight-activated knee locking mechanism

US 10369017	Ramakrishnan et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Tyagi Ramakrishnan (Tampa, Florida); Kyle B. Reed (Tampa, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida)
INVENTOR(S)	Tyagi Ramakrishnan (Tampa, Florida); Kyle B. Reed (Tampa, Florida)
ABSTRACT	A passive knee locking mechanism using the position of the shank and the weight of the user to lock. The mechanism has translational motion, which allows the shank to move linearly along the sagittal/vertical plane, which locks and unlocks the knee, and rotational motion for the shank to swing when unlocked. The knee block, which is disposed at the top of the shank, has a spur gear that locks with a matching gear rack on the top plate of the knee housing. The side plates for the knee housing have a linear path that makes for the translational motion. During heel strike, the stopper in the front plate of the knee housing positions the shank in a straight position. When the user applies their weight for initiating stance phase, the knee block traverses up the path and the spur gear meshes with the matching rack, locking the knee.
FILED	Monday, April 18, 2016
APPL NO	15/131571
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/64 (20130101) Original (OR) Class A61F 2/68 (20130101) A61F 2002/607 (20130101) A61F 2002/6836 (20130101) A61F 2002/6854 (20130101)
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10369021 — Powered orthotic system for cooperative overground rehabilitation

US 10369021	Zoss et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Ekso Bionics, Inc. (Richmond, California)
ASSIGNEE(S)	Ekso Bionics, Inc. (Richmond, California)
INVENTOR(S)	Adam Zoss (Berkeley, California); Tim Swift (Clovis, California); Alec Berg (San Mateo, California); Katherine Strausser (Berkeley, California); Erick Brendan St. John (Pleasanton, California)
ABSTRACT	A powered orthotic system, such as an exoskeleton, is employed for overground rehabilitation purposes by adapting and adjusting to real-time needs in a rehabilitation situation whereby the system can be initially controlled to perform gait functions for a wearer based on a predetermined level of assistance but the predetermined level of assistance can be varied, based on one or more rehabilitation parameters or specific needs of the wearer undergoing therapy, through the application and adjustment of appropriate variables associated with operation of the system.
FILED	Thursday, March 13, 2014
APPL NO	14/776485
ART UNIT	3785 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/112 (20130101) A61B 5/1122 (20130101) A61B 5/4836 (20130101) A61B 5/4851 (20130101) A61B 5/6811 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/68 (20130101) Original (OR) Class A61F 5/01 (20130101) A61F 5/0102 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/024 (20130101) A61H 3/00 (20130101) A61H 3/008 (20130101) A61H 2003/007 (20130101) A61H 2201/165 (20130101) A61H 2201/5007 (20130101) A61H 2201/5061 (20130101) A61H 2201/5069 (20130101)
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10369104 — Targeted polymerized nanoparticles for cancer treatment

US 10369104	Nagy et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Children's Hospital Los Angeles (Los Angeles, California); Nanovalent Pharmaceuticals, Inc. (Bozeman, Montana)
ASSIGNEE(S)	Children's Hospital Los Angeles (Los Angeles, California); Nanovalent Pharmaceuticals, Inc. (Bozeman, Montana)
INVENTOR(S)	Jon O. Nagy (Bozeman, Montana); Tim Triche (Los Angeles, California); Hyung-Gyoo Kang (Buena Park, California)
ABSTRACT	The invention relates to a novel drug delivery vehicle. Various embodiments of the invention provide a hybrid polymerized liposomal nanoparticle comprising both polymerizable lipids and non-polymerizable lipids. Therapeutic agents can be loaded into the polymerized liposomal nanoparticle and targeting agents can be conjugated to the surface of the polymerized liposomal nanoparticle. Also described in the invention are methods, compositions and kits that utilize the hybrid polymerized liposomal nanoparticle to treat disease conditions such as various cancers.
FILED	Wednesday, April 01, 2015
APPL NO	15/301020
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1273 (20130101) Original (OR) Class A61K 31/136 (20130101) A61K 31/136 (20130101) A61K 31/337 (20130101) A61K 31/337 (20130101) A61K 31/407 (20130101) A61K 31/407 (20130101) A61K 31/475 (20130101) A61K 31/475 (20130101) A61K 31/573 (20130101) A61K 31/573 (20130101) A61K 31/704 (20130101) A61K 31/704 (20130101) A61K 31/713 (20130101) A61K 31/713 (20130101) A61K 31/4745 (20130101) A61K 31/4745 (20130101) A61K 31/7068 (20130101) A61K 31/7068 (20130101) A61K 33/24 (20130101) A61K 33/24 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) Y10S 977/907 (20130101)
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10369253 — Method for modifying surfaces for better osseointegration

US 10369253	Bhaduri et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The University of Toledo (Toledo, Ohio)
ASSIGNEE(S)	The University of Toledo (Toledo, Ohio)
INVENTOR(S)	Sarit B. Bhaduri (Holland, Ohio); Vijay K. Goel (Holland, Ohio); Huan Zhou (Toledo, Ohio)
ABSTRACT	In one aspect, there is provided a method for preparing a biocompatible coated substrate. The method generally includes: depositing nucleation amorphous calcium phosphate sites on at least a portion of an outer surface of a substrate by: exposing at least the portion of the outer surface to a mixture having a favorable Ca/P molar ratio, and irradiating with microwave energy; and, stabilizing the deposited nucleation amorphous calcium phosphate sites on the portion of the outer surface. In another aspect, there is provided herein a method for preparing a biocompatible coated substrate.
FILED	Wednesday, October 31, 2012
APPL NO	14/355051
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/00 (20130101) A61L 27/12 (20130101) A61L 27/32 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 29/106 (20130101) A61L 31/086 (20130101) A61L 2400/18 (20130101) A61L 2430/02 (20130101)
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10369459 — Tactile, interactive neuromorphic robots

US 10369459	Bucci et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Liam David Bucci (Irvine, California); Ting-Shuo Chou (Irvine, California); Jeffrey Lawrence Krichmar (Cardiff By The Sea, California)
ABSTRACT	In one embodiment, a neuromorphic robot includes a curved outer housing that forms a continuous curved outer surface, a plurality of trackball touch sensors provided on and extending across the continuous curved outer surface in an array, each trackball sensor being configured to detect a direction and velocity a sweeping stroke of a user, and a plurality of lights, one light being collocated with each trackball touch sensor and being configured to illuminate when its collocated trackball touch sensor is stroked by the user, wherein the robot is configured to interpret the sweeping stroke of the user sensed with the plurality of trackball touch sensors and to provide immediate visual feedback to the user at the locations of the touched trackball touch sensors.
FILED	Monday, May 21, 2018
APPL NO	15/984880
ART UNIT	3717 — Printing/Measuring and Testing
CURRENT CPC	Card, Board, or Roulette Games; Indoor Games Using Small Moving Playing Bodies; Video Games; Games Not Otherwise Provided for A63F 9/24 (20130101) Original (OR) Class A63F 9/0604 (20130101) A63F 2009/2408 (20130101) A63F 2009/2447 (20130101) Toys, e.g Tops, Dolls, Hoops or Building Blocks A63H 11/00 (20130101) A63H 33/005 (20130101) A63H 2200/00 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 2219/40625 (20130101) G05B 2219/40627 (20130101) Electric Digital Data Processing G06F 2203/04103 (20130101) Computer Systems Based on Specific Computational Models G06N 3/008 (20130101) G06N 3/049 (20130101)
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10369529 — Mixed matrix membranes with embedded polymeric particles and networks and related compositions, methods, and systems

US 10369529	Diallo et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (Daejeon, South Korea)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (Daejeon, South Korea)
INVENTOR(S)	Mamadou S. Diallo (Pasadena, California); Madhusudhana Rao Kotte (Daejeon, South Korea)
ABSTRACT	Described herein are mixed matrix filtration membranes and related, compositions, methods and systems and in particular mixed matrix filtration membranes with an embedded polymer network and/or embedded polymeric micro/nanoparticles functionalized with a functionalization polymer covalently and/or non covalently linked to the micro/nanoparticles and related compositions, methods, and systems.
FILED	Wednesday, July 30, 2014
APPL NO	14/447574
ART UNIT	1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 67/0079 (20130101) B01D 69/10 (20130101) B01D 69/12 (20130101) B01D 69/141 (20130101) Original (OR) Class B01D 71/022 (20130101) B01D 71/34 (20130101) B01D 71/40 (20130101) B01D 71/60 (20130101) B01D 2323/30 (20130101) B01D 2323/39 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) C02F 1/441 (20130101) C02F 1/444 (20130101) C02F 2103/08 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/10 (20130101)
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10369544 — Method of synthesizing novel adsorbent titanosilicate material (UPRM-5) using NR4+ type cations

US 10369544	Hernandez-Maldonado et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Human Resource Development (HRD)
APPLICANT(S)	Arturo J. Hernandez-Maldonado (Mayaguez, Puerto Rico); Marietta E. Marcano-Gonzalez (Mayaguez, Puerto Rico); Jose N. Primera-Pedrozo (Mayaguez, Puerto Rico)
ASSIGNEE(S)	University of Puerto Rico (San Juan, Puerto Rico)
INVENTOR(S)	Arturo J. Hernandez-Maldonado (Mayaguez, Puerto Rico); Marietta E. Marcano-Gonzalez (Mayaguez, Puerto Rico); Jose N. Primera-Pedrozo (Mayaguez, Puerto Rico)
ABSTRACT	The invention employs tetrapropylammonium (TPA⁺) and tetrabutylammonium (TBA⁺) as structure directing agents (SDAs), respectively for the preparation of the flexible titanium silicate UPRM-5. Both UPRM-5 variants are detemplated and modified to include extraframework Sr²⁺ and produce materials for carbon dioxide adsorption.
FILED	Monday, May 13, 2013
APPL NO	13/893284
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/10 (20130101) B01J 20/3057 (20130101) Original (OR) Class B01J 20/3085 (20130101) Non-metallic Elements; Compounds Thereof; C01B 39/02 (20130101) C01B 39/04 (20130101) C01B 39/085 (20130101)
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10370246 — Portable and low-error DNA-based data storage

US 10370246	Milenkovic et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Olgica Milenkovic (Urbana, Illinois); Ryan Gabrys (San Diego, California); S. M. Hossein Tabatabaei Yazdi (Urbana, Illinois)
ABSTRACT	The present disclosure provides DNA-based storage system demonstrated through experimental and theoretical verification that such a platform can easily be implemented in practice using portable, nanopore-based sequencers. The gist of the approach is to design an integrated pipeline that encodes data to avoid synthesis and sequencing errors, enables random access through addressing, and leverages efficient portable nanopore sequencing via new anchored iterative alignment and insertion/deletion error-correcting codes. The embodiments herein represent the only known random access DNA-based data storage system that uses error-prone portable, nanopore-based sequencers and produces low-error readouts with the highest reported information rate and density.
FILED	Friday, October 20, 2017
APPL NO	15/789519
ART UNIT	2824 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6806 (20130101) Computer Systems Based on Specific Computational Models G06N 3/12 (20130101) G06N 3/123 (20130101) Static Stores G11C 13/025 (20130101)
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10370270 — Electrodes for cost-effective bio-electrochemical systems

US 10370270	Silver et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Cambrian Innovation, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	Matthew Silver (Cambridge, Massachusetts); Justin Buck (Cambridge, Massachusetts); Casey Chartier (Cambridge, Massachusetts); Mark Barosky (Boston, Massachusetts); James Ryan Hawkins (Boston, Massachusetts); Zhen Huang (Newton, Massachusetts); Quynh Anh Le Tran (Springfield, Massachusetts); Tzipora Wagner (Somerville, Massachusetts)
ABSTRACT	An electrode for use in bio-electrochemical systems is described, including: a substantially planar electrode material; a frame comprising a non-conductive substance; and one or more first conductive substances linked or secured to the frame. Bio-electrochemical systems, racks for inserting the electrode, and methods of using the racks are also described.
FILED	Monday, November 24, 2014
APPL NO	14/551462
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/46109 (20130101) Original (OR) Class C02F 3/005 (20130101) C02F 11/006 (20130101) C02F 2001/46133 (20130101) C02F 2001/46142 (20130101) C02F 2001/46152 (20130101) C02F 2001/46161 (20130101) C02F 2201/4611 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/20 (20130101) C25D 13/22 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9075 (20130101) H01M 8/16 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/343 (20130101) Y02E 60/527 (20130101)
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10370306 — Polymer composite having dispersed transition metal oxide particles

US 10370306	Reid et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Central Florida Research Foundation, Inc. (Orlando, Florida)
ASSIGNEE(S)	University of Central Florida Research Foundation, Inc. (Orlando, Florida); Texas A and M University System (College Station, Texas)
INVENTOR(S)	David L. Reid (Orlando, Florida); Sudipta Seal (Orlando, Florida); Eric Petersen (College Station, Texas); Robert Draper (Orlando, Florida)
ABSTRACT	A method of forming polymer composites having transition metal oxide nanoparticles dispersed therein includes mixing a transition metal oxide precursor including at least one transition metal, a polymer as a binder, a solvent for the polymer, and water to form a first solution including polymer-transition metal complexes. The polymer-transition metal complexes are hydrolyzed to produce a plurality of transition metal oxide nanoparticles, wherein water is added in the mixing in a stoichiometric excess for the hydrolyzing. The solvent and residual of the water remaining after the hydrolyzing are removed. A polymer composite including a plurality of transition metal oxide nanoparticles dispersed in the polymer results after the removing, where some of the polymer is chemically conjugated to a surface of the transition metal oxide nanoparticles.
FILED	Tuesday, March 12, 2013
APPL NO	13/797448
ART UNIT	1768 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 23/007 (20130101) C06B 45/10 (20130101) C06B 45/105 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 136/06 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/205 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) Compositions of Macromolecular Compounds C08L 13/00 (20130101)
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10370415 — Divalent nucleobase compounds and uses therefor

US 10370415	Ly et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	Carnegie Mellon University (Pittsburgh, Pennsylvania)
INVENTOR(S)	Danith H. Ly (Pittsburgh, Pennsylvania); Suresh Kumar Gopalsamy (Tamilnadu, India); Arunava Manna (Pittsburgh, Pennsylvania)
ABSTRACT	Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
FILED	Friday, April 11, 2014
APPL NO	14/782471
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 239/47 (20130101) C07D 239/54 (20130101) C07D 251/16 (20130101) C07D 471/04 (20130101) C07D 475/08 (20130101) C07D 487/04 (20130101) C07D 487/16 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/06 (20130101) C07H 21/04 (20130101) Peptides C07K 14/003 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101)
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10370418 — Engineered microorganisms having resistance to ionic liquids

US 10370418	Thelen et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Michael P. Thelen (Danville, California); Douglas A. Higgins (Point Pleasant, New Jersey); Thomas L. Ruegg (Berkeley, California)
ABSTRACT	The present invention provides for a method of genetically modifying microorganisms to enhance resistance to ionic liquids using a yeast Major Facilitator Superfamily (MFS), or a Salmonella MFS SmvA Pump or SmvR Regulator, a Small Multidrug Resistance Family (SMR), or Saccharomyces cerevisiae YDR090C, polypeptide, host cells genetically modified in accordance with the methods, and methods of using the host cells in a reaction comprising biomass that has been pretreated with ionic liquids.
FILED	Wednesday, May 20, 2015
APPL NO	14/717962
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/255 (20130101) Original (OR) Class C07K 14/395 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/16 (20130101) C12N 1/20 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) C12P 2203/00 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/16 (20130101)
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10370477 — Broad wavelength range chemically tunable photonic materials

US 10370477	Kang et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Youngjong Kang (Kyounggi-Do, South Korea); Joseph Walish (Cambridge, Massachusetts); Edwin L. Thomas (Houston, Texas)
ABSTRACT	The present invention provides polymeric materials arranged as photonic crystals, or portions of photonic crystals, having properties which can be easily tuned over a large range of wavelengths upon exposure to an external stimulus. In some embodiments, the photonic crystals comprise at least one portion which can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus, resulting in a change in a diffracted wavelength of electromagnetic radiation (e.g, light) by the photonic crystal. Embodiments of the invention may advantageously exhibit large stop band tunability and rapid response times. Photonic crystals of the invention may be useful in a wide variety of applications, such as colorimetric sensors, active components of simple display devices, electrically controlled tunable optically pumped laser, photonic switches, multiband filters, and the like.
FILED	Monday, May 09, 2016
APPL NO	15/150320
ART UNIT	1763 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 293/00 (20130101) Original (OR) Class Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/12 (20130101) Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) G02B 5/20 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/15 (20130101) G02F 1/061 (20130101) G02F 1/0121 (20130101) G02F 1/0147 (20130101) G02F 2001/164 (20190101) G02F 2202/022 (20130101) G02F 2202/32 (20130101) G02F 2202/36 (20130101) G02F 2203/023 (20130101)
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10370661 — Nucleic acid functionalized nanoparticles for therapeutic applications

US 10370661	Mirkin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad A. Mirkin (Wilmette, Illinois); Nathaniel L. Rosi (Chicago, Illinois); C. Shad Thaxton (Chicago, Illinois); David A. Giljohann (Chicago, Illinois)
ABSTRACT	Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.
FILED	Wednesday, July 19, 2017
APPL NO	15/654401
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/5115 (20130101) A61K 31/7088 (20130101) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/314 (20130101) C12N 2310/315 (20130101) C12N 2310/351 (20130101) C12N 2310/3181 (20130101) C12N 2320/32 (20130101)
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10370675 — Transgenic plants exhibiting enhanced phytochelatin-based heavy metal tolerance and methods of use thereof

US 10370675	Rea et al.
FUNDED BY	Department of Energy (DOE) Environmental Protection Agency (EPA) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB) Department of Agriculture (USDA)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Washington University in St. Louis (St. Louis, Missouri); Donald Danforth Plant Science Center (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S)	Philip A. Rea (Ardmore, Pennsylvania); Joseph Jez (Kirkwood, Missouri); Rebecca Cahoon (Lincoln, Nebraska)
ABSTRACT	Transgenic plants exhibiting phytochelatin-based heavy metal tolerance and methods of use thereof for bioremediation are disclosed.
FILED	Tuesday, May 23, 2017
APPL NO	15/602757
ART UNIT	1663 — Plants
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/32 (20130101) C02F 2101/20 (20130101) C02F 2103/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/104 (20130101) C12N 15/8271 (20130101) Original (OR) Class Enzymes C12Y 203/02015 (20130101)
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10370690 — Microorganisms for producing glycogen and methods of using same

US 10370690	Pfleger et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Office of Emerging Frontiers in Research and Innovation (EFRI)
APPLICANT(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	Brian F. Pfleger (Madison, Wisconsin); Andrew L. Markley (Madison, Wisconsin)
ABSTRACT	Recombinant microorganisms configured for increased glycogen production. The recombinant microorganisms comprise a recombinant nucleic acid configured to express or overexpress a glucose-1-phosphate adenylyltransferase. The recombinant microorganisms produce an increased amount of glycogen compared to a corresponding microorganism not comprising the recombinant nucleic acid.
FILED	Friday, December 07, 2018
APPL NO	16/213319
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/1241 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) Original (OR) Class Enzymes C12Y 207/07027 (20130101)
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10370705 — Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes

US 10370705	Ismagilov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Chicago (Chicago, Illinois)
ASSIGNEE(S)	University of Chicago (Chicago, Illinois)
INVENTOR(S)	Rustem F. Ismagilov (Altadena, California); Feng Shen (Chicago, Illinois); Jason E. Kreutz (Chicago, Illinois); Bing Sun (Chicago, Illinois); Wenbin Du (Chicago, Illinois)
ABSTRACT	Provided are devices and methods for effecting processing of samples, including essentially isothermal amplification of nucleic acids, at multiple reaction locations in a single device. In some embodiments, the disclosed devices and methods provide for effecting parallel sample processing in several hundred locations on a single device.
FILED	Thursday, August 25, 2016
APPL NO	15/247795
ART UNIT	1799 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 13/0094 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5025 (20130101) B01L 3/502715 (20130101) B01L 3/502738 (20130101) B01L 2200/027 (20130101) B01L 2300/0864 (20130101) B01L 2300/0896 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) Original (OR) Class C12Q 1/6851 (20130101) C12Q 2531/119 (20130101) C12Q 2537/149 (20130101) C12Q 2563/159 (20130101) C12Q 2565/629 (20130101)
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10370805 — Adjustable bolted steel plate connection

US 10370805	Thrall et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	University of Notre Dame du Lac (South Bend, Indiana); HNTB Corporation (New York, New York)
ASSIGNEE(S)	University of Notre Dame du Lac (Notre Dame, Indiana); HNTB Corporation (New York, New York)
INVENTOR(S)	Ashley P. Thrall (Notre Dame, Indiana); Evan J. Gerbo (Notre Dame, Indiana); Theodore P. Zoli, III (New York, New York)
ABSTRACT	An adjustable structural connection can be used to join steel structural elements at a range of angles and is capable of adjusting in situ to accommodate additional angles or tolerances through cold bending. Pre-bent plate or plates may be loosely fitted around steel structural elements, such that holes in the plates align with holes of the steel structural elements. Placing bolts through the aligned holes and tightening those bolts can be used to cold bend the plate or plates and conform the angle of the pre-bent plates to a different angle defined by an apex joint of two steel structural elements. Specific tightening procedures may be employed.
FILED	Wednesday, May 31, 2017
APPL NO	15/610451
ART UNIT	3671 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Construction of Bridges, or Viaducts; Assembly of Bridges E01D 4/00 (20130101) E01D 6/00 (20130101) Original (OR) Class E01D 15/133 (20130101) Structural Elements; Building Materials E04C 3/08 (20130101) E04C 3/40 (20130101) E04C 2003/0491 (20130101)
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10371740 — Power system disturbance localization using recurrence quantification analysis and minimum-volume-enclosing ellipsoid

US 10371740	Cui et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
INVENTOR(S)	Yi Cui (Knoxville, Tennessee); Feifei Bai (Macgregor, Australia); Wenxuan Yao (Knoxville, Tennessee); Yong Liu (Knoxville, Tennessee); Ling Wu (Knoxville, Tennessee); Yilu Liu (Knoxville, Tennessee)
ABSTRACT	A method for determining a location of a disturbance in a power system is provided. The method includes receiving data from a plurality of sensors distributed across the power system; performing a recurrence quantification analysis on the received data to identify a predetermined number of sensors, from the plurality of sensors, that are closest to the disturbance; constructing a plurality of minimum-volume-enclosing ellipsoids based on and enclosing the data received from the identified sensors; extracting one or more parameters from the plurality of minimum-volume-enclosing ellipsoids; inputting the one or more parameters into a multivariate-random-forest regression algorithm to determine the location of the disturbance and a power mismatch corresponding to the disturbance; and presenting, on one or more display units, the determined location of the disturbance and the determined power mismatch.
FILED	Wednesday, May 31, 2017
APPL NO	15/609861
ART UNIT	2862 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 31/086 (20130101) Original (OR) Class G01R 31/088 (20130101) Systems for Regulating Electric or Magnetic Variables G05F 1/66 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101) Emergency Protective Circuit Arrangements H02H 1/0092 (20130101)
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10372148 — Power system disturbance location determination based on rate of change of frequency

US 10372148	You et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
INVENTOR(S)	Shutang You (Knoxville, Texas); Dao Zhou (Knoxville, Tennessee); Ling Wu (Knoxville, Tennessee); Yilu Liu (Knoxville, Tennessee)
ABSTRACT	A method for determining a location of a disturbance in a power system is provided. The method includes receiving data from a plurality of sensors distributed across the power system; determining, with one or more processors, for each sensor, an extremum of the data corresponding to the sensor; interpolating, with the one or more processors, the extrema; and presenting, on one or more display units, a location corresponding to a global maximum of the interpolated extrema as the location of the disturbance. The method may further include, if a difference between the largest extremum and each of remaining extremum is greater than a predetermined threshold, skipping the interpolating step and the presenting step, and presenting a location of the sensor corresponding to the largest extremum as the location of the disturbance.
FILED	Wednesday, November 16, 2016
APPL NO	15/353341
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/048 (20130101) G05B 2219/31356 (20130101) Systems for Regulating Electric or Magnetic Variables G05F 1/66 (20130101) Original (OR) Class
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10372736 — Generating and implementing local search engines over large databases

US 10372736	Li et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S)	University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Feifei Li (Salt Lake City, Utah); Cody Hansen (Salt Lake City, Utah)
ABSTRACT	A computing system receives as inputs data records stored in a database. The computing parses the data records into file pairs that each include a keyword file and record ID file and merge file pairs into a keyword file and record ID file, where the keyword file includes keywords in sorted order, and where the record ID file includes a list of record IDs for keywords in the keyword file. The computing system further creates an offset file which stores offset values for starting addresses of record ID lists in the record ID file, and generates an index of keywords by assigning unique identifiers to keywords in the keyword file. The computing system also provides a query interface that allows the database's data records to be searched using the generated index of keywords.
FILED	Friday, May 16, 2014
APPL NO	14/891318
ART UNIT	2169 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/313 (20190101) G06F 16/319 (20190101) Original (OR) Class G06F 16/334 (20190101) G06F 16/3331 (20190101) G06F 17/2705 (20130101)
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10373512 — Mathematical language processing: automatic grading and feedback for open response mathematical questions

US 10373512	Lan et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	WILLIAM MARSH RICE UNIVERSITY (Houston, Texas)
ASSIGNEE(S)	William Marsh Rice University (Houston, Texas)
INVENTOR(S)	Shiting Lan (Houston, Texas); Divyanshu Vats (Houston, Texas); Andrew E. Waters (Sugar Land, Texas); Richard G. Baraniuk (Houston, Texas)
ABSTRACT	Mechanisms for automatically grading a large number of solutions provided by learners in response to an open response mathematical question. Each solution is mapped to a corresponding feature vector based on the mathematical expressions occurring in the solution. The feature vectors are clustered using a conventional clustering method, or alternatively, using a presently-disclosed Bayesian nonparametric clustering method. A representative solution is selected from each solution cluster. An instructor supplies a grade for each of the representative solutions. Grades for the remaining solutions are automatically generated based on their cluster membership and the instructor supplied grades. The Bayesian method may also automatically identify the location of an error in a given solution. The error location may be supplied to the learner as feedback. The error location may also be used to extract information from correct solutions. The extracted information may be supplied to a learner as a solution hint.
FILED	Friday, December 11, 2015
APPL NO	14/967131
ART UNIT	3715 — Amusement and Education Devices
CURRENT CPC	Electric Digital Data Processing G06F 17/10 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 7/04 (20130101) Original (OR) Class
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10373812 — Enhanced thermonic energy converter and method of use

US 10373812	Paxton, IV et al.
FUNDED BY	National Science Foundation (NSF) Office of The Director (OD) Office of Experimental Program to Stimulate Competitive Research (EPSCOR)
APPLICANT(S)	William F. Paxton, IV (Nashville, Tennessee); Jim L. Davidson (Brentwood, Tennessee); Weng P. Kang (Brentwood, Tennessee); Mick E. Howell (Murfreesboro, Tennessee)
ASSIGNEE(S)
INVENTOR(S)	William F. Paxton, IV (Nashville, Tennessee); Jim L. Davidson (Brentwood, Tennessee); Weng P. Kang (Brentwood, Tennessee); Mick E. Howell (Murfreesboro, Tennessee)
ABSTRACT	A thermionic energy converter includes an anode, a cathode spaced from the anode to define a gap therebetween and an operating environment of hydrogen wherein the anode and the cathode are disposed in the hydrogen operating environment so that molecular hydrogen is incorporated into the gap and the anode and the cathode are substantially exposed to the molecular hydrogen. Exposure of diamond samples to a hydrogen plasma reduces the resistance of the bulk diamond film. Hydrogen enhances electron transport through the bulk of the diamond and improves the thermionic emission current. Impregnation of a diamond electrode with hydrogen enhances bulk electron transport of the diamond due to hydrogen lying in the interstitial space between the carbon atoms. Hydrogen increases the bulk conductivity of diamonds films by interact with the diamond surface to form polarized C—H bonds reducing the electron affinity and in turn, reducing the work function. Exposure of diamond cathodes to a low energy hydrogen plasma drastically enhances thermionic emission current relative to as-grown diamond films by up to four orders of magnitude due to surface termination of diamond with hydrogen (i.e. hydrogenation of the diamond surface). Difficulty arises when attempting to utilize hydrogenated diamond electrodes for thermionic generators due to the hydrogen desorbing from the diamond surface following a predictable time-dependent Arrhenius behavior. When hydrogenated diamond cathodes are heated to temperatures above 600° C., the desorption of the performance-enhancing hydrogen begin to decrease with increasing temperature. The present invention provides means for preventing desorption of hydrogen from hydrogenated diamond films at elevated temperatures to overcome the performance-limiting effect of the desorbtion of the hydrogen from the diamond surface by filling the gap between the cathode and anode with molecular hydrogen at a selected specific pressure in equilibrium. The thermionic generator is sealed and pressure remains constant or steady-state so that molecular hydrogen is introduced into the gap at a selected flow rate to replace any molecular hydrogen exiting the gap at the same flow rate whereby a selected pressure and volume of hydrogen is maintained in the gap throughout the process.
FILED	Monday, November 06, 2017
APPL NO	15/804118
ART UNIT	2834 — Electrical Circuits and Systems
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/274 (20130101) C23C 16/278 (20130101) C23C 16/511 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) Original (OR) Class
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10374105 — Optoelectronic device including a buried metal grating for extraordinary optical transmission (EOT)

US 10374105	Li et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Xiuling Li (Champaign, Illinois); Daniel M. Wasserman (West Lake Hills, Texas); Xiang Zhao (San Jose, California)
ABSTRACT	An optoelectronic device includes an etched body comprising a buried metal contact layer on a top surface of a semiconductor structure, which comprises one or more semiconductor layers. The buried metal contact layer includes an arrangement of holes therein. A plurality of nanopillar structures protrude from the top surface of the semiconductor structure and pass through the arrangement of holes. Each nanopillar structure is surrounded at a base thereof by a portion of the buried metal contact layer. When the etched body is exposed to incident radiation having a wavelength in the range from about 300 nm to about 10 microns, at least about 50% of the incident radiation is transmitted through the etched body at a peak transmission wavelength λ_max.
FILED	Friday, July 01, 2016
APPL NO	15/200345
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/133509 (20130101) G02F 2202/36 (20130101) G02F 2203/055 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0725 (20130101) H01L 31/0735 (20130101) H01L 31/02005 (20130101) H01L 31/02008 (20130101) H01L 31/02327 (20130101) Original (OR) Class H01L 31/035218 (20130101) H01L 33/06 (20130101) H01L 33/58 (20130101) H01L 33/62 (20130101) H01L 2933/0058 (20130101) H01L 2933/0066 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/544 (20130101)
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10374262 — Protective cathode coatings for lithium-ion batteries

US 10374262	Aykol et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	Muratahan Aykol (Moraga, California); Soo Kim (Skokie, Illinois); Shiqiang Hao (Glenview, Illinois); Zhi Lu (Evanston, Illinois); Vinay Ishwar Hegde (Chicago, Illinois); David H. Snydacker (Evanston, Illinois); Scott J. Kirklin (Evanston, Illinois); Dane Morgan (Middleton, Wisconsin); Christopher M. Wolverton (Evanston, Illinois)
ABSTRACT	Cathode coatings for lithium ion batteries, cathodes coated with the coatings, and lithium ion batteries incorporating the coated cathodes are provided. The coatings, which are composed of binary, ternary, and higher order metal oxides and/or metalloid oxides, can reduce the hydrofluoric acid (HF)-induced degradation of the electrolyte and/or cathodes, thereby improving the performance of lithium ion batteries, relative to lithium ion batteries that employ bare cathodes.
FILED	Wednesday, February 08, 2017
APPL NO	15/427295
ART UNIT	1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 10/4235 (20130101) Original (OR) Class
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10374385 — Hybrid silicon lasers and amplifiers with 2D phosphorene film

US 10374385	Husko et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois); NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois); NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Chad Husko (Wauconda, Illinois); Jeff Guest (Lemont, Illinois); Mark Hersam (Evanston, Illinois); Joohoon Kang (Evanston, Illinois); Joshua Wood (Evanston, Illinois); Xavier Checoury (Rue Andre Ampere, France)
ABSTRACT	Hybrid silicon lasers and amplifiers having resonator cavities within a silicon substrate and a two-dimensional material film on the substrate as an optical gain medium are described. The two-dimensional material film may be formed of one or more atomic layers of phosphorene (BP). The number of phosphorene layers may be adjusted to tune the emission wavelength of the hybrid devices.
FILED	Friday, September 15, 2017
APPL NO	15/706109
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/12 (20130101) H01S 5/021 (20130101) Original (OR) Class H01S 5/041 (20130101) H01S 5/50 (20130101) H01S 5/105 (20130101) H01S 5/125 (20130101) H01S 5/0425 (20130101) H01S 5/1042 (20130101) H01S 5/2054 (20130101)
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10374441 — Balanced control strategies for interconnected heterogeneous battery systems in smart grid applications

US 10374441	Wang et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Wayne State University (Detroit, Michigan)
ASSIGNEE(S)	Wayne State University (Detroit, Michigan)
INVENTOR(S)	Le Y. Wang (Novi, Michigan); Caisheng Wang (Troy, Michigan); George Yin (Northville, Michigan); Feng Lin (Troy, Michigan); Michael P. Polis (Grosse Pointe Park, Michigan)
ABSTRACT	A battery network includes a plurality of heterogeneous batteries coupled to at least one energy source and one energy load, a plurality of switches coupled to the heterogeneous batteries, and the switches controllable having a duty cycle between 0 and 1. A controller is configured to characterize each of the plurality of heterogeneous batteries characteristics, determine duty cycles for each of the plurality of switches based on the characterization such that a charge applied from the at least one energy source or a discharge to the at least one energy load converges to a balanced state for the plurality of heterogeneous batteries, and apply the determined duty cycles to the plurality of switches.
FILED	Thursday, July 16, 2015
APPL NO	15/326600
ART UNIT	2836 — Electrical Circuits and Systems
CURRENT CPC	Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/32 (20130101) H02J 7/0018 (20130101) Original (OR) Class H02J 2007/005 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 80/11 (20151101)
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10374577 — Optimal response reflectionless filters

US 10374577	Morgan
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Astronomical Sciences (AST) National Radio Astronomy Observatory (NRAO) Federally Funded Research and Development Center (FFRDC) Operated by Associated Universities, Inc. (AUI)at Charlottesville, VA
APPLICANT(S)	Associated Universities, Inc. (Washington, District of Columbia)
ASSIGNEE(S)	Associated Universities, Inc. (Washington, District of Columbia)
INVENTOR(S)	Matthew Alexander Morgan (Earlysville, Virginia)
ABSTRACT	Reflectionless low-pass, high-pass, band-pass, band-stop, all-pass, all-stop, and multi-band filters, as well as a method for designing such filters is disclosed, along with a method of enhancing the performance of such filters through the use of unmatched sub-networks to realize an optimal frequency response, such as the Chebyshev equal-ripple response. These filters preferably function by absorbing the stop-band portion of the spectrum rather than reflecting it back to the source, which has significant advantages in many different applications. The unmatched sub-networks preferably offer additional degrees of freedom by which element values can be assigned to realize improved cutoff sharpness, stop-band rejection, or other measures of performance. The elements of the filter may be physical passive elements, or synthesized with active circuits, potentially realizing even negative element-values for improved performance.
FILED	Tuesday, November 14, 2017
APPL NO	15/811850
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/06 (20130101) H03H 7/38 (20130101) H03H 11/10 (20130101) Original (OR) Class
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10374676 — Channel tracking and transmit beamforming with frugal feedback

US 10374676	Sidiropoulos et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS) Directorate for Mathematical and Physical Sciences (MPS) Division of Astronomical Sciences (AST)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Nikolaos D. Sidiropoulos (Edina, Minnesota); Omar A. Mehanna (San Jose, California)
ABSTRACT	In general, this disclosure describes techniques for beamforming using limited feedback that exploit the spatio-temporal channel correlation and avoid the limitations of codebook-based feedback and Markov chain modeling. In one example, a receiving device includes a plurality of receive antennas for receiving communication information, a memory for storing the communication information, and one or more processors for processing the communication information. The one or more processors are configured to receive, through a wireless communication channel, a pilot signal transmitted by a transmitting device, determine, based on the received pilot signal, channel state feedback comprising a quantized representation of the pilot signal as received at the receiving device, and send, through the wireless communication.
FILED	Thursday, April 20, 2017
APPL NO	15/492916
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 7/08 (20130101) H04B 7/0417 (20130101) H04B 7/0421 (20130101) H04B 7/0619 (20130101) H04B 7/0621 (20130101) H04B 7/0626 (20130101) Original (OR) Class H04B 7/0636 (20130101) H04B 7/0639 (20130101) H04B 7/0695 (20130101) H04B 17/24 (20150115)
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10374759 — High throughput communication system

US 10374759	Wesel et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Richard Wesel (Los Angeles, California); Kasra Vakilinia (Los Angeles, California); Sudarsan V S Ranganathan (Los Angeles, California); Dariush Divsalar (Pacific Palisades, California); Haobo Wang (Los Angeles, California)
ABSTRACT	A high throughput communication apparatus which provides low frame error rates (FER). Error checking encoder and decoders which each comprise a plurality of short blocklength error checking encoders or decoders, respectively, in parallel, coupled through common incremental redundancy. Short-blocklength codes are utilized to achieve communication capacity with incremental redundancy. The system can transmit and decode a large number of short-blocklength codewords in parallel, while it delivers incremental redundancy, without feedback, only to the decoders that need incremental redundancy.
FILED	Sunday, May 13, 2018
APPL NO	15/978165
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 1/22 (20130101) Original (OR) Class H04L 1/0057 (20130101) H04L 1/0059 (20130101) H04L 1/0061 (20130101) H04L 1/0068 (20130101) H04L 1/165 (20130101)
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National Aeronautics and Space Administration (NASA)

10369544 — Method of synthesizing novel adsorbent titanosilicate material (UPRM-5) using NR4+ type cations

US 10369544	Hernandez-Maldonado et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Human Resource Development (HRD)
APPLICANT(S)	Arturo J. Hernandez-Maldonado (Mayaguez, Puerto Rico); Marietta E. Marcano-Gonzalez (Mayaguez, Puerto Rico); Jose N. Primera-Pedrozo (Mayaguez, Puerto Rico)
ASSIGNEE(S)	University of Puerto Rico (San Juan, Puerto Rico)
INVENTOR(S)	Arturo J. Hernandez-Maldonado (Mayaguez, Puerto Rico); Marietta E. Marcano-Gonzalez (Mayaguez, Puerto Rico); Jose N. Primera-Pedrozo (Mayaguez, Puerto Rico)
ABSTRACT	The invention employs tetrapropylammonium (TPA⁺) and tetrabutylammonium (TBA⁺) as structure directing agents (SDAs), respectively for the preparation of the flexible titanium silicate UPRM-5. Both UPRM-5 variants are detemplated and modified to include extraframework Sr²⁺ and produce materials for carbon dioxide adsorption.
FILED	Monday, May 13, 2013
APPL NO	13/893284
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/10 (20130101) B01J 20/3057 (20130101) Original (OR) Class B01J 20/3085 (20130101) Non-metallic Elements; Compounds Thereof; C01B 39/02 (20130101) C01B 39/04 (20130101) C01B 39/085 (20130101)
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10369767 — Blocking/deblocking resin systems for use as a “co-cure-ply” in the fabrication of large-scale composite structure

US 10369767	Palmieri et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	U.S.A. as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Frank L. Palmieri (Hampton, Virginia); John W. Connell (Yorktown, Virginia); Christopher J. Wohl, Jr. (Portsmouth, Virginia)
ABSTRACT	A method for bonding composite structures which includes providing a first and second composite substrate and coupling a co-cure prepreg tape having chemically protected polymerizable functional groups onto a surface of both the first and second composite substrates. The first and second composite substrates are then cured to the co-cure prepreg tape at a first temperature to form a co-cure prepreg tape portion where the first and second composite substrates are fully cured and the co-cure prepreg tape is partially cured. The co-cure prepreg tape portion of the first composite substrate is then coupled to the co-cure prepreg tape portion of the second composite substrate and a deprotection initiator is applied to facilitate deprotection of the chemically protected polymerizable functional groups and cure the co-cure prepreg tape portion of the first and second composite substrates to form a single covalently bonded composite structure.
FILED	Friday, September 23, 2016
APPL NO	15/274147
ART UNIT	1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 65/02 (20130101) B29C 65/14 (20130101) B29C 65/4835 (20130101) B29C 65/5014 (20130101) B29C 65/5057 (20130101) B29C 66/43 (20130101) B29C 66/71 (20130101) B29C 66/71 (20130101) B29C 66/0242 (20130101) B29C 66/721 (20130101) B29C 66/919 (20130101) B29C 66/1122 (20130101) B29C 66/73752 (20130101) B29C 66/73754 (20130101) B29C 66/73941 (20130101) B29C 66/81455 (20130101) B29C 66/91445 (20130101) B29C 66/91921 (20130101) B29C 70/30 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2063/00 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/12 (20130101) Original (OR) Class B32B 27/34 (20130101) B32B 2305/74 (20130101) B32B 2305/77 (20130101) B32B 2309/02 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 5/06 (20130101)
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10370080 — Removable window system for space vehicles

US 10370080	Grady
FUNDED BY	National Aeronautics and Space Administration (NASA) John F. Kennedy Space Center (KSC)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	James P. Grady (Irvine, California)
ABSTRACT	A method for manipulating a window system in a platform is provided. A biasing system may be removed that biases a retention frame toward a support frame while the support frame and the retention frame hold a window pane. The retention frame may be removed after removing the biasing system. The window pane may be removed.
FILED	Monday, December 14, 2015
APPL NO	14/968886
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Windows, Windscreens, Non-fixed Roofs, Doors, or Similar Devices for Vehicles; Removable External Protective Coverings Specially Adapted for Vehicles B60J 1/00 (20130101) Ships or Other Waterborne Vessels; Equipment for Shipping B63B 19/00 (20130101) Aeroplanes; Helicopters B64C 1/1484 (20130101) Original (OR) Class B64C 1/1492 (20130101) Cosmonautics; Vehicles or Equipment Therefor B64G 1/10 (20130101) B64G 1/60 (20130101)
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10370100 — Aerodynamically actuated thrust vectoring devices

US 10370100	Rothhaar et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
INVENTOR(S)	Paul M. Rothhaar (Yorktown, Virginia); William J. Fredericks (Williamsburg, Virginia); David D. North (Williamsburg, Virginia)
ABSTRACT	A vehicle includes a wing and a control surface pivotably coupled to the wing and configured to pivot about a range of motion. A propulsor is coupled to the control surface and configured to rotate between a first position associated with a hover flight mode and a second position associated with a forward flight mode. The propulsor is aerodynamically actuated between the first position and the second position due to aerodynamics about the wing. The propulsor may rotate from an initial flight mode, such as a takeoff mode, to a second flight mode, such as a forward flight mode.
FILED	Tuesday, March 22, 2016
APPL NO	15/077268
ART UNIT	3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 9/04 (20130101) B64C 29/0033 (20130101) Original (OR) Class Climate Change Mitigation Technologies Related to Transportation Y02T 50/32 (20130101) Y02T 50/44 (20130101)
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10370127 — Apparatus for aligning and connecting signal connectors on two different bodies

US 10370127	Michael et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Richard Michael (Lanham, Maryland); Thomas J. Hanyok (Lanham, Maryland); Beth A. Keer (Greenbelt, Maryland)
ABSTRACT	An apparatus to align and connect complementary signal connectors on two different bodies comprises a housing having a housing support structure, a front side and a rear side. A first drive system on one body is used to operate a threaded shaft to join the two bodies. A second drive system that includes a rotatable shaft that is used to drive a cam to advance a signal connector panel on the one body to connect to a signal connector on the other body.
FILED	Thursday, September 27, 2018
APPL NO	16/143833
ART UNIT	2831 — Electrical Circuits and Systems
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/641 (20130101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/502 (20130101) H01R 13/631 (20130101) H01R 25/006 (20130101)
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10370706 — Molecular recognition systems with pyrimidine analog pairing

US 10370706	Hoshika et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Shuichi Hoshika (Gainesville, Florida); Nicole A Leal (Gainesville, Florida); Steven A Benner (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S)	Shuichi Hoshika (Gainesville, Florida); Nicole A Leal (Gainesville, Florida); Steven A Benner (Gainesville, Florida)
ABSTRACT	This invention covers a new molecular recognition system, where duplexes of DNA-like molecules comprise segments built from nucleotides that carry only a small pyrimidine-like analog, and where the segments pair by pyrimidine analog:pyrimidine analog “skinny” pairing. This pairing retains hydrogen bonding complementarity. Further, this invention relates to processes for preparing those duplexes, and processes that use such duplexes as primer:template complexes for reactions catalyzed by DNA polymerases.
FILED	Friday, August 24, 2018
APPL NO	16/111590
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6853 (20130101) Original (OR) Class C12Q 2533/101 (20130101) Enzymes C12Y 207/07007 (20130101)
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10371523 — Rotation and acceleration sensor based on superluminal ring lasers

US 10371523	Shahriar et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Missile Defense Agency (MDA) National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Digital Optics Technologies, Incorporated (Rolling Meadows, Illinois)
ASSIGNEE(S)	Digital Optics Technologies, Inc. (Rolling Meadows, Illinois)
INVENTOR(S)	Selim M. Shahriar (Kildeer, Illinois); Nicholas J. Condon (Evanston, Illinois); Devin J. Hileman (Des Plaines, Illinois); Shih C. Tseng (Arlington Heights, Illinois)
ABSTRACT	Ring laser gyroscopes, in which rotation is detected by the Sagnac effect between counterpropagating lasers, are in common use in navigation applications. The invention disclosed here uses an induced strong anomalous dispersion inside the ring laser cavities to create a group velocity of as much as 10⁶times greater than the vacuum speed of light, with a corresponding increase in gyroscope sensitivity; the resulting device is referred to as a Superluminal Ring Laser Gyroscope (SRLG). The invention disclosed here also incorporates an acceleration-sensing element that modifies the path length of the ring lasers in the gyroscope, the effects of which on the output of the gyroscope can be separated from those of rotation. The resulting composite device is a Superluminal Ring Laser Gyroscope/Accelerometer (SRLGA).
FILED	Wednesday, January 18, 2017
APPL NO	15/530464
ART UNIT	2886 — Optics
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/68 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/305 (20130101) H01S 3/0835 (20130101) H01S 3/2366 (20130101)
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10371579 — Black silicon blackbody calibration target

US 10371579	Johnson et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America as Represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	William R. Johnson (Brea, California); Karl Y. Yee (Pasadena, California); Simon J. Hook (Pasadena, California)
ABSTRACT	The disclosure is directed to a blackbody calibration target having a textured silicon substrate comprising a base comprising a plurality of needle like structures extending away from the base and having a total emissivity of greater than 99.5% from an electromagnetic radiation source having a wavelength greater than or equal to about 400 nanometers and less than or equal to about 1 mm. The disclosure is further directed to a blackbody calibration target system, and instrument which includes the blackbody calibration target, and a method of calibrating an instrument.
FILED	Wednesday, December 21, 2016
APPL NO	15/386821
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/522 (20130101) Original (OR) Class
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10371640 — Compositions and methods for leukocyte differential counting

US 10371640	Tai et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) National Space Biomedical Research Institute (NSBRI)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Yu-Chong Tai (Pasadena, California); Wendian Shi (Sierra Madre, California); Harvey Kasdan (Jerusalem, Israel)
ABSTRACT	The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from each of the one or more leukocyte types to classify the leukocyte population.
FILED	Tuesday, July 11, 2017
APPL NO	15/647039
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/05 (20130101) G01N 21/6428 (20130101) G01N 21/6486 (20130101) Original (OR) Class G01N 2021/0346 (20130101) G01N 2021/6441 (20130101) G01N 2021/6482 (20130101)
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10374000 — Thermal-contraction matched hybrid device package

US 10374000	Cooper et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	TELEDYNE SCIENTIFIC and IMAGING, LLC (Thousand Oaks, California)
ASSIGNEE(S)	TELEDYNE SCIENTIFIC and IMAGING, LLC (Thousand Oaks, California)
INVENTOR(S)	Donald E. Cooper (Moorpark, California); Lisa L. Fischer (Ventura, California)
ABSTRACT	A hybrid device package comprising a baseplate, a balanced composite structure (BCS) on the baseplate, a first IC on the BCS, and at least one additional IC physically coupled to the first IC. The coefficient of thermal expansion (CTE) for the stack formed from the BCS and the first IC is arranged to be approximately equal to that of the baseplate, thereby reducing the thermal stress to which the at least one additional IC is subjected when cooled to its operating temperature which might otherwise result in physical damage to the IC. The baseplate is preferably an alumina ceramic baseplate. In one embodiment, the first IC is a readout IC (ROIC), the at least one additional IC is a detector array IC which is on the ROIC, and the hybrid device package is a focal plane array (FPA).
FILED	Monday, September 23, 2013
APPL NO	14/034306
ART UNIT	2878 — Optics
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1465 (20130101) Original (OR) Class H01L 27/14618 (20130101) H01L 2224/48091 (20130101) H01L 2224/48091 (20130101) H01L 2224/73265 (20130101) H01L 2924/00014 (20130101)
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10374852 — Ka-band modulator and transmitter

US 10374852	Huang et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Wei-Chung Huang (College Park, Maryland); Jeffrey M. Jaso (Olney, Maryland)
ABSTRACT	The present invention relates to a high data rate Ka-band modulator and transmitter for space applications that functions on the entire NASA Space Network Return Link band of 25.25-27.75 GHz. The modulator is capable of quadrature phase-shift keying (QPSK) modulation and 8-PSK modulation. The transmitter can be designed to provide an adjustable drive to a traveling-wave tube amplifier (TWTA) or transmit power.
FILED	Monday, September 10, 2018
APPL NO	16/125938
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 7/18582 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0041 (20130101) H04L 1/0058 (20130101) H04L 7/048 (20130101) H04L 7/0091 (20130101) H04L 25/03834 (20130101) H04L 27/2053 (20130101) Original (OR) Class
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10374975 — Dynamic priority calculator for priority based scheduling

US 10374975	Teter et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Marcus A. Teter (Belgrade, Montana); John J. Doubrava (Bennett, Colorado); Brenda S. Dougherty (Denver, Colorado); Jeanette Marie Booher (Denver, Colorado); Noah M. Anderson (Omaha, Nebraska)
ABSTRACT	Discussed herein are methods, devices, and systems for providing a priority-based schedule. A method or providing a priority-based schedule can include receiving, at priority processing circuitry, for each of a plurality of nodes to be scheduled, a plurality of priority type values and a corresponding weighting factor value for each priority type value of the plurality type values, determining, at the priority processing circuitry, for each of the plurality of nodes to be scheduled, a priority total based on the received plurality of priority type values and the corresponding weighting factor values, and scheduling, using scheduler circuitry communicatively coupled to the priority processing circuitry, the plurality of nodes, such that a node of the plurality of nodes with a corresponding higher priority is allocated access to the medium before another node of the plurality of nodes with a corresponding relatively lower priority.
FILED	Saturday, November 12, 2016
APPL NO	15/350031
ART UNIT	2472 — Multiplex and VoIP
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 47/805 (20130101) Original (OR) Class H04L 47/826 (20130101)
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Department of Agriculture (USDA)

10369212 — H3 influenza A virus

US 10369212	Olsen et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin)
INVENTOR(S)	Christopher W. Olsen (Madison, Wisconsin); Gabriele A. Landolt (Fort Collins, Colorado); Alexander I. Karasin (Madison, Wisconsin)
ABSTRACT	The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof.
FILED	Friday, June 22, 2018
APPL NO	16/015504
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0043 (20130101) A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/54 (20130101) A61K 2039/70 (20130101) A61K 2039/525 (20130101) A61K 2039/543 (20130101) A61K 2039/552 (20130101) A61K 2039/5252 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16121 (20130101) C12N 2760/16122 (20130101) C12N 2760/16134 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 1/91 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/11 (20130101)
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10370675 — Transgenic plants exhibiting enhanced phytochelatin-based heavy metal tolerance and methods of use thereof

US 10370675	Rea et al.
FUNDED BY	Department of Energy (DOE) Environmental Protection Agency (EPA) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB) Department of Agriculture (USDA)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Washington University in St. Louis (St. Louis, Missouri); Donald Danforth Plant Science Center (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S)	Philip A. Rea (Ardmore, Pennsylvania); Joseph Jez (Kirkwood, Missouri); Rebecca Cahoon (Lincoln, Nebraska)
ABSTRACT	Transgenic plants exhibiting phytochelatin-based heavy metal tolerance and methods of use thereof for bioremediation are disclosed.
FILED	Tuesday, May 23, 2017
APPL NO	15/602757
ART UNIT	1663 — Plants
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/32 (20130101) C02F 2101/20 (20130101) C02F 2103/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/104 (20130101) C12N 15/8271 (20130101) Original (OR) Class Enzymes C12Y 203/02015 (20130101)
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10370689 — Production of lysergic acid by genetic modification of a fungus

US 10370689	Panaccione et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	West Virigina University (Morgantown, West Virginia)
ASSIGNEE(S)	West Virginia University (Morgantown, West Virginia)
INVENTOR(S)	Daniel G. Panaccione (Morgantown, West Virginia); Sarah L. Robinson (Independence, West Virginia)
ABSTRACT	The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) or any fungus having a pathway similar to Aspergillus fumigatus and expressing one or more genes of the ergot alkaloid biosynthesis pathway from one or more fungus selected from the group consisting of Epichloë festucae var. lolii×Epichloë typhina isolate Lp1 (E. sp. Lp1); Claviceps species; Claviceps africana (C. africana); Claviceps gigantea (C. gigantea); Epichloë coenophiala and Periglandula species, wherein gene easA or gene easM is inactivated in said A. fumigatus or said fungus having a pathway similar to Aspergillus fumigatus, is provided.
FILED	Monday, September 11, 2017
APPL NO	15/700598
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/182 (20130101) Original (OR) Class
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10371277 — Methods for controlling operation of a valve

US 10371277	Needham et al.
FUNDED BY	Small Business Administration (SBA) Small Business Innovation Research (SBIR) Department of Agriculture (USDA) Agricultural Research Service (ARS) Cooperative State Research, Education, and Extension Service (CSREES)
APPLICANT(S)	Capstan Ag Systems, Inc. (Topeka, Kansas)
ASSIGNEE(S)	Capstan Ag Systems, Inc. (Topeka, Kansas)
INVENTOR(S)	Duane Needham (San Francisco, California); Andrew J. Holtz (Atascadero, California)
ABSTRACT	An electric solenoid valve, methods for operating and/or actuating the solenoid valve, valve system diagnostics, and applications for use are described. The valve may be designed to actuate in a manner so as to control liquid flow into and/or through a device, such as a spray nozzle. By altering the characteristics of the electrical signal transmitted to the solenoid valve, the instantaneous pressure across the valve and duration of fluid flow through the valve can be controlled with a single actuator. Controlled cyclic durations of flow may be implemented to regulate the exact timing of flow through the valve. Alternatively, cyclic durations may occur with a pulse-width modulation technique in which the duty cycle regulates average flow rate through the valve.
FILED	Friday, September 02, 2016
APPL NO	15/255548
ART UNIT	3649 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 25/16 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 12/008 (20130101) B05B 12/085 (20130101) B05B 12/087 (20130101) B05B 15/50 (20180201) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 31/0606 (20130101) Original (OR) Class F16K 31/0627 (20130101) F16K 31/0658 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 16/2013 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) Y10T 137/86413 (20150401)
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Department of Veterans Affairs (DVA)

10369150 — Benzathine analogs

US 10369150	Chen et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Beibei Chen (Sewickley, Pennsylvania); Rama K. Mallampalli (Sewickley, Pennsylvania)
ABSTRACT	A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R¹-R¹⁰are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R³or R⁸is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.
FILED	Wednesday, October 10, 2018
APPL NO	16/156902
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/341 (20130101) A61K 31/381 (20130101) A61K 31/402 (20130101) A61K 31/427 (20130101) A61K 31/435 (20130101) A61K 31/444 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4178 (20130101) A61K 31/4418 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 11/06 (20180101) A61P 19/00 (20180101) A61P 25/00 (20180101) A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 211/01 (20130101) C07C 211/53 (20130101) C07C 229/38 (20130101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 211/14 (20130101) C07D 213/06 (20130101) C07D 213/36 (20130101) C07D 213/38 (20130101) C07D 231/12 (20130101) C07D 233/61 (20130101) C07D 233/64 (20130101) C07D 239/26 (20130101) C07D 265/30 (20130101) C07D 277/28 (20130101) C07D 295/135 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) Technologies for Adaptation to Climate Change Y02A 50/411 (20180101) Y02A 50/473 (20180101)
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10369254 — Method and apparatus for in vitro kidney organogenesis

US 10369254	Yanagawa et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); U.S. Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); U.S. DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
INVENTOR(S)	Norimoto Yanagawa (Pacific Palisades, California); Masaki Nishikawa (Van Nuys, California); Morgan Hamon (Northridge, California); Peter Viktor Hauser (Los Angeles, California)
ABSTRACT	The invention provides for a device, system, and methods for using the same with kidney progenitor cells, specifically ureteric bud (UB) cells, metanephric mesenchymal (MM) cells, and the stromal cell (SC) subpopulation of the metanephric mesenchyme, to generate an embryonic kidney organoid that can be implanted into a mammalian subject to create a living, functional kidney.
FILED	Friday, February 06, 2015
APPL NO	15/121551
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3604 (20130101) Original (OR) Class A61L 27/3683 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) C12M 23/58 (20130101) C12M 25/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) C12N 2502/256 (20130101)
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10370328 — Oxindole compounds and pharmaceutical compositions thereof

US 10370328	Beeson et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina); U.S. DEPARTMENT OF VETERANS AFFAIRS (NW Washington, District of Columbia)
ASSIGNEE(S)	MUSC Foundation for Research Development (Charleston, South Carolina)
INVENTOR(S)	Craig C. Beeson (Charleston, South Carolina); Christopher C. Lindsey (Wadmalaw Island, South Carolina); Baerbel Rohrer (Charleston, South Carolina); Yuri Karl Peterson (Charleston, South Carolina)
ABSTRACT	Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
FILED	Thursday, April 28, 2016
APPL NO	15/565820
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Heterocyclic Compounds C07D 209/34 (20130101) C07D 209/36 (20130101) C07D 209/38 (20130101) Original (OR) Class C07D 401/06 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/06 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 405/06 (20130101) C07D 405/12 (20130101) C07D 413/06 (20130101) C07D 498/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/5728 (20130101)
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10370728 — Antibiotic susceptibility testing using probes for preribosomal RNA

US 10370728	Haake et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
INVENTOR(S)	David A. Haake (Culvert City, California); Colin Halford (Los Angeles, California); Jane T. Babbitt (Culver City, California); Bernard M. Churchill (Pacific Palisades, California)
ABSTRACT	Described are probes and methods for detecting antibiotic susceptibility of a specimen. The method comprises contacting the specimen with an oligonucleotide probe that specifically hybridizes with a target nucleic acid sequence region of ribosomal RNA. The target sequence is at the junction between a pre-ribosomal RNA tail and mature ribosomal RNA of 23S or 16S rRNA. Performing the method in the presence and absence of an antibiotic permits detection of antibiotic susceptibility.
FILED	Friday, May 03, 2013
APPL NO	14/398725
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/106 (20130101)
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Small Business Administration (SBA)

10369173 — Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy

US 10369173	Kreke et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Capricor, Inc. (Beverly Hills, California)
ASSIGNEE(S)	Capricor, Inc. (Beverly Hills, California)
INVENTOR(S)	Michelle Kreke (Marina del Rey, California); Rachel Smith (Cary, North Carolina)
ABSTRACT	The present disclosure relates generally to methods for the increased processing of tissue for the generation of cardiac stem cells, wherein the stem cells are suitable for use in cardiac stem cell therapy. In particular, several embodiments relate to the processing of allogeneic donor cardiac tissue for the generation of multiple patient doses of cardiac stem cells.
FILED	Monday, December 11, 2017
APPL NO	15/837549
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) A61K 35/34 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2500/32 (20130101) C12N 2501/91 (20130101) C12N 2509/00 (20130101) C12N 2523/00 (20130101)
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10371277 — Methods for controlling operation of a valve

US 10371277	Needham et al.
FUNDED BY	Small Business Administration (SBA) Small Business Innovation Research (SBIR) Department of Agriculture (USDA) Agricultural Research Service (ARS) Cooperative State Research, Education, and Extension Service (CSREES)
APPLICANT(S)	Capstan Ag Systems, Inc. (Topeka, Kansas)
ASSIGNEE(S)	Capstan Ag Systems, Inc. (Topeka, Kansas)
INVENTOR(S)	Duane Needham (San Francisco, California); Andrew J. Holtz (Atascadero, California)
ABSTRACT	An electric solenoid valve, methods for operating and/or actuating the solenoid valve, valve system diagnostics, and applications for use are described. The valve may be designed to actuate in a manner so as to control liquid flow into and/or through a device, such as a spray nozzle. By altering the characteristics of the electrical signal transmitted to the solenoid valve, the instantaneous pressure across the valve and duration of fluid flow through the valve can be controlled with a single actuator. Controlled cyclic durations of flow may be implemented to regulate the exact timing of flow through the valve. Alternatively, cyclic durations may occur with a pulse-width modulation technique in which the duty cycle regulates average flow rate through the valve.
FILED	Friday, September 02, 2016
APPL NO	15/255548
ART UNIT	3649 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 25/16 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 12/008 (20130101) B05B 12/085 (20130101) B05B 12/087 (20130101) B05B 15/50 (20180201) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 31/0606 (20130101) Original (OR) Class F16K 31/0627 (20130101) F16K 31/0658 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 16/2013 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) Y10T 137/86413 (20150401)
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10373928 — Method for electrically interconnecting at least two substrates and multichip module

US 10373928	Dotsenko
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Communications-Electronics Research, Development and Engineering Center (CERDEC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Hypres, Inc. (Elmsford, New York)
ASSIGNEE(S)	Hypres, inc. (Elmsford, New York)
INVENTOR(S)	Vladimir V. Dotsenko (Mahopac, New York)
ABSTRACT	A method for electrically interconnecting two substrates, each having a corresponding set of preformed electrical contacts, the substrates comprising an electronic circuit, and the resulting module, is provided. A liquid curable adhesive is provided over the set of contacts of a first substrate, and the set of electrical contacts of the second substrate is aligned with the set of electrical contacts of the first substrate. The sets of electrical contacts of the first and second substrate are compressed to displace the liquid curable adhesive from the inter-contact region, and provide electrical communication between the respective sets of electrical contacts. The liquid curable adhesive is then cured to form a solid matrix which maintains a relative compression between the respective sets of electrical contacts. One embodiment of the module comprises a high-speed superconducting circuit which operates at cryogenic temperatures.
FILED	Monday, May 01, 2017
APPL NO	15/583414
ART UNIT	2848 — Electrical Circuits and Systems
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 24/13 (20130101) H01L 24/29 (20130101) H01L 24/73 (20130101) H01L 24/83 (20130101) Original (OR) Class H01L 25/04 (20130101) H01L 25/50 (20130101) H01L 39/045 (20130101) H01L 39/2493 (20130101) H01L 2224/2919 (20130101) H01L 2224/13109 (20130101) H01L 2224/13111 (20130101) H01L 2224/73204 (20130101) H01L 2224/83862 (20130101) H01L 2924/0132 (20130101) H01L 2924/0665 (20130101)
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10374551 — Subcritical-voltage magnetron RF power source

US 10374551	Kazakevich et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Small Business Administration (SBA) Small Business Technology Transfer (STTR)
APPLICANT(S)	Muons, Inc. (Batavia, Illinois)
ASSIGNEE(S)	Muons, Inc. (Batavia, Illinois)
INVENTOR(S)	Grigory M. Kazakevich (North Aurora, Illinois); Michael L. Neubauer (San Francisco, California); Valeri A. Lebedev (Wheaton, Illinois); Vyacheslav P. Yakovlev (Batavia, Illinois)
ABSTRACT	A system and method of operating a magnetron power source can achieve a broad range of output power control by operating a magnetron with its cathode voltage lower than that needed for free running oscillations (e.g., below the Kapitsa critical voltage or equivalently below the Hartree voltage) A sufficiently strong injection-locking signal enables the output power to be coherently generated and to be controlled over a broad power range by small changes in the cathode voltage. In one embodiment, the present system and method is used for a practical, single, frequency-locked 2-magnetron system design.
FILED	Sunday, February 12, 2017
APPL NO	15/430497
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 9/10 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/02 (20130101) H05H 2007/025 (20130101)
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Department of Homeland Security (DHS)

10369229 — Methods and compositions for liposomal formulation of antigens and uses thereof

US 10369229	Fujii et al.
FUNDED BY	Department of Homeland Security (DHS) Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); MOLECULAR EXPRESS, INC. (Rancho Dominquez, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); MOLECULAR EXPRESS, INC. (Rancho Dominguez, California)
INVENTOR(S)	Gary Fujii (Rancho Palos Verdes, California); Francis C. Szoka (San Francisco, California); Douglas S. Watson (Harrisonburg, Virginia)
ABSTRACT	The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
FILED	Monday, April 02, 2018
APPL NO	15/943382
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 39/07 (20130101) A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 39/385 (20130101) A61K 47/543 (20170801) A61K 47/554 (20170801) A61K 47/6911 (20170801) A61K 47/6913 (20170801) Original (OR) Class A61K 2039/60 (20130101) A61K 2039/627 (20130101) A61K 2039/6018 (20130101) A61K 2039/55555 (20130101) A61K 2039/55572 (20130101) Steroids C07J 9/00 (20130101) C07J 41/0055 (20130101) C07J 43/003 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16134 (20130101) C12N 2760/16134 (20130101) C12N 2770/00011 (20130101) C12N 2770/00034 (20130101)
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10371688 — Sensing system based on a fluorophore array

US 10371688	Euler
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	Rhode Island Board of Education, State of Rhode Island and Providence Plantations (Providence, Rhode Island)
ASSIGNEE(S)
INVENTOR(S)	William B. Euler (Narragansett, Rhode Island)
ABSTRACT	A sensing system for explosives is provided. The sensor is based on a layered structure of approximately a monolayer of a fluorophore deposited onto a few nm of a transparent polymer, supported by a substrate. The fluorophores can be xanthene laser dyes, which have high quantum yields, and the polymers can be commodity materials polymethylmethacrylate and polyvinylidene difluoride. The different fluorophore/polymer combinations give different emission responses to analytes, including both signal quenching and enhancement. The pattern of responses can be used to identify the analyte. The common explosives TNT, PETN, RDX, HMX, and TATP as gas phase species can all be uniquely identified at room temperature using only the natural vapor pressure of the explosive to deliver sample to the sensor.
FILED	Friday, February 10, 2017
APPL NO	15/430320
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/643 (20130101) G01N 33/0057 (20130101) G01N 33/227 (20130101) Original (OR) Class G01N 2021/6432 (20130101)
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10371813 — Systems and methods for using time of flight measurements for imaging target objects

US 10371813	Furxhi et al.
FUNDED BY	Department of Homeland Security (DHS) Science and Technology Directorate (DHS-ST)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Orges Furxhi (Sanford, Florida); Ruoyu Zhu (Durham, North Carolina); David J. Brady (Durham, North Carolina); Daniel Marks (Durham, North Carolina)
ABSTRACT	An imaging system as disclosed can include multiple bistatic radar sensors configured to transmit electromagnetic waves towards a surface of a target object and configured to measure the electromagnetic waves reflected from the surface of the target object. The imaging system includes a computing device that determines time of flight estimates based on the measured waves. The computing device can draw, within an image model for the target object, multiple candidate surface portions of the surface of the target object based on the TOF estimates and predetermined positions of the bistatic radar sensors. Further, the computing device can assign weights to the candidate surface portions. The computing device can determine points where the candidate surface portions meet with a predetermined probability based on the weights. The computing device is configured to define an estimated surface of the target object in the image model based on the determined points.
FILED	Wednesday, August 13, 2014
APPL NO	14/896375
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/352 (20130101) G01S 13/003 (20130101) G01S 13/34 (20130101) G01S 13/87 (20130101) G01S 13/89 (20130101) Original (OR) Class
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United States Postal Service (USPS)

10373098 — Flexible mail delivery system and method

US 10373098	Kuebert et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
INVENTOR(S)	Edward J. Kuebert (Warrenton, Virginia); Scott R. Bombaugh (Burke, Virginia); William J. Dowling (Venice, Florida)
ABSTRACT	The principles of the present invention provide the ability to flexibly change the delivery point and time for a mail item, while the item is en route. The recipient, sender, or mailer may flexibly change the delivery point of the item alone or in combination with each other. While an item is en route between the sending point and the delivery point, a notification is sent to indicate that the item is in transit. In response, the delivery of the item may be changed. For example, the destination specified by the sender (e.g., the delivery address written on the item) may be changed or a delivery time may be specified. The item is then delivered to the new delivery point and/or at the specified delivery time.
FILED	Monday, July 07, 2014
APPL NO	14/325031
ART UNIT	3628 — Business Methods - Incentive Programs, Coupons; Operations Research; Electronic Shopping; Health Care; Point of Sale, Inventory, Accounting; Cost/ Price, Reservations, Shipping and Transportation; Business Processing
CURRENT CPC	Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/08 (20130101) G06Q 10/083 (20130101) G06Q 10/0832 (20130101) G06Q 10/0833 (20130101) Original (OR) Class G06Q 10/08355 (20130101) G06Q 30/0283 (20130101) G06Q 30/0637 (20130101)
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D0855929 — Cluster box mail delivery unit

US D855929	Mikolajczyk et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
INVENTOR(S)	Ryszard K. Mikolajczyk (Chicago, Illinois); Taurris D. Baskerville (Schaumburg, Illinois)
ABSTRACT
FILED	Thursday, June 21, 2018
APPL NO	29/654220
ART UNIT	2912 — Design
CURRENT CPC	Miscellaneous D99/32
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Classified Government Agency

10370125 — Satellite control system

US 10370125	Smith et al.
FUNDED BY	Classified Government Agency
APPLICANT(S)	HONEYWELL INTERNATIONAL INC. (Morristown, New Jersey)
ASSIGNEE(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
INVENTOR(S)	Douglas Edward Smith (Phoenix, Arizona); Don Crippen (Glendale, Arizona); Joshua Matthew Stiles (Surprise, Arizona); Mostafa Sayed (Scottsdale, Arizona)
ABSTRACT	A vehicle, a satellite control system, and a method for controlling the same are provided. The satellite control system, for example, may include, but is not limited to, a control moment gyroscope having a gimbal, at least one gimbal angle sensor configured to determine an angle of the gimbal, each gimbal angle sensor having an output circuit configured to output the determined angle, a signal conditioner circuit having substantially identical circuit topology as the output circuit, and a common mode error compensation circuit electrically coupled to the signal conditioner, the common mode error compensation circuit configured to determine common mode error in the gimbal angle sensor based upon a voltage output from the signal conditioner circuit and to output a signal to compensate for the common mode error.
FILED	Tuesday, January 13, 2015
APPL NO	14/595580
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/10 (20130101) B64G 1/36 (20130101) Original (OR) Class B64G 1/286 (20130101) B64G 1/428 (20130101)
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Department of Commerce (DOC)

10370751 — Thermomechanical processing of alpha-beta titanium alloys

US 10370751	Thomas et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	ATI PROPERTIES LLC (Albany, Oregon)
ASSIGNEE(S)	ATI PROPERTIES LLC (Albany, Oregon)
INVENTOR(S)	Jean-Phillippe A. Thomas (Charlotte, North Carolina); Ramesh S. Minisandram (Charlotte, North Carolina); Robin M. Forbes Jones (Charlotte, North Carolina); John V. Mantione (Indian Trail, North Carolina); David J. Bryan (Indian Trail, North Carolina)
ABSTRACT	One embodiment of a method of refining alpha-phase grain size in an alpha-beta titanium alloy comprises working an alpha-beta titanium alloy at a first working temperature within a first temperature range in the alpha-beta phase field of the alpha-beta titanium alloy. The alloy is slow cooled from the first working temperature. On completion of working at and slow cooling from the first working temperature, the alloy comprises a primary globularized alpha-phase particle microstructure. The alloy is worked at a second working temperature within a second temperature range in the alpha-beta phase field. The second working temperature is lower than the first working temperature. The is worked at a third working temperature in a third temperature range in the alpha-beta phase field. The third working temperature is lower than the second working temperature. After working at the third working temperature, the titanium alloy comprises a desired refined alpha-phase grain size.
FILED	Wednesday, July 26, 2017
APPL NO	15/659661
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Alloys C22C 14/00 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/183 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Environmental Protection Agency (EPA)

10370675 — Transgenic plants exhibiting enhanced phytochelatin-based heavy metal tolerance and methods of use thereof

US 10370675	Rea et al.
FUNDED BY	Department of Energy (DOE) Environmental Protection Agency (EPA) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB) Department of Agriculture (USDA)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Washington University in St. Louis (St. Louis, Missouri); Donald Danforth Plant Science Center (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S)	Philip A. Rea (Ardmore, Pennsylvania); Joseph Jez (Kirkwood, Missouri); Rebecca Cahoon (Lincoln, Nebraska)
ABSTRACT	Transgenic plants exhibiting phytochelatin-based heavy metal tolerance and methods of use thereof for bioremediation are disclosed.
FILED	Tuesday, May 23, 2017
APPL NO	15/602757
ART UNIT	1663 — Plants
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/32 (20130101) C02F 2101/20 (20130101) C02F 2103/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/104 (20130101) C12N 15/8271 (20130101) Original (OR) Class Enzymes C12Y 203/02015 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Security Agency (NSA)

10373071 — Automated intelligent data navigation and prediction tool

US 10373071	Klinger et al.
FUNDED BY	National Security Agency (NSA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Tamir Klinger (Brooklyn, New York); Chandrasekhara K. Reddy (Kinnelon, New Jersey); Ashish Sabharwal (White Plains, New York); Horst C. Samulowitz (Port Chester, New York); Gerald J. Tesauro (Croton-On-Hudson, New York); Deepak S. Turaga (Elmsford, New York)
ABSTRACT	A system, method, and computer program product for automatically selecting from a plurality of analytic algorithms a best performing analytic algorithm to apply to a dataset is provided. The automatically selecting from the plurality of analytic algorithms the best performing analytic algorithm to apply to the dataset enables a training a plurality of analytic algorithms on a plurality of subsets of the dataset. Then, a corresponding prediction accuracy trend is estimated across the subsets for each of the plurality of analytic algorithms to produce a plurality of accuracy trends. Next, the best performing analytic algorithm is selected and outputted from the plurality of analytic algorithms based on the corresponding prediction accuracy trend with a highest value from the plurality of accuracy trends.
FILED	Tuesday, November 24, 2015
APPL NO	14/951040
ART UNIT	2122 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

U.S. State Government

10370679 — Modified immunization vectors

US 10370679	Pantaleo et al.
FUNDED BY	U.S. State Government State of Arizona
APPLICANT(S)	Arizona Board of Regents, a body corporate of the State of Arizona acting for and on behalf of Arizona State University (Phoenix, Arizona); Consejo Superior De Investigaciones Cientificas (Madrid, Spain); IPPOX Foundation (Lausanne, Switzerland)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS, a body corporate of the State of Arizona acting for and on behalf of Ariz (Phoenix, Arizona); CONSEJO SUPERIOR DE INVESTGACIONES CIENTRIFICAS (Madrid, Spain); IPPOX FOUNDATION (Lausanne, Switzerland)
INVENTOR(S)	Giuseppe Pantaleo (Lausanne, Switzerland); Thierry Calandra (Lausanne, Switzerland); Alexandre Harari (Lausanne, Switzerland); Thierry Roger (Lausanne, Switzerland); Mariano Esteban (Madrid, Spain); Bertram Jacobs (Phoenix, Arizona); Karen Kibler (Phoenix, Arizona); Cornelius Melief (Leiden, Netherlands); Rafick-Pierre Sekaly (Montreal, Canada); Elias El Haddad (Montreal, Canada); James Tartaglia (Toronto, Canada)
ABSTRACT	The disclosure relates to recombinant vectors and methods for using the same. In certain embodiments, the recombinant vectors are immunogenic.
FILED	Monday, October 10, 2016
APPL NO	15/289297
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/275 (20130101) A61K 39/295 (20130101) A61K 49/00 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2710/24143 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10371856 — Zero dead-time gravimeter

US 10371856	Kasevich et al.
FUNDED BY
APPLICANT(S)	AOSense, Inc. (Sunnyvale, California)
ASSIGNEE(S)	AOSense, Inc. (Sunnyvale, California)
INVENTOR(S)	Mark A. Kasevich (Palo Alto, California); Miroslav Y. Shverdin (Mountain View, California)
ABSTRACT	An atomic gravimeter device includes one or more lasers and three or more atomic sources. The three or more atomic sources are disposed to launch or drop atoms vertically. The one or more lasers are disposed to generate laser beams that interact with sets of atoms from an atomic source of the three or more atomic sources to measure accelerations of the sets of atoms. A measured value is determined for gravity using interwoven acceleration measurements of the sets of atoms from the three or more atomic sources.
FILED	Monday, February 13, 2017
APPL NO	15/430982
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 7/02 (20130101) G01V 7/04 (20130101) Original (OR) Class G01V 7/005 (20130101) G01V 7/06 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10374491 — Electric motor

US 10374491	Flaxman
FUNDED BY
APPLICANT(S)	QINETIQ LIMITED (Farnborough, United Kingdom)
ASSIGNEE(S)	QINETIQ LIMITED (Hampshire, United Kingdom)
INVENTOR(S)	Robert John Bonner Flaxman (Guildford, United Kingdom)
ABSTRACT	Some embodiments are directed to an electric motor that includes a stator including a plurality of circumferentially distributed drive elements for causing an electromagnetic driving force to be applied to a rotor of the electric motor in use. Each drive element includes a wire extending around a metal core to define a plurality of coils for magnetizing the metal core when current flows in the coils. At least one space exists between the metal core of each respective drive element and the coils around it. A cooling device is provided for transferring heat away from the drive elements. Each drive element further includes a heat conductor including a plurality of mutually electrically isolated metallic elements located in the or each respective space between the metal core thereof and the coils around it, for transferring heat from the coils to the cooling device.
FILED	Friday, May 22, 2015
APPL NO	15/310712
ART UNIT	2834 — Electrical Circuits and Systems
CURRENT CPC	Dynamo-electric Machines H02K 3/18 (20130101) H02K 9/19 (20130101) H02K 9/22 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, August 06, 2019.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20190806.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

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