FedInvent™ Patents

Patent Details for Tuesday, December 03, 2019

This page was updated on Monday, March 27, 2023 at 05:57 AM GMT

Department of Defense (DOD)

10492555 — Helmet mounting system

US 10492555	Lebel et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Stéphane Lebel (St. Redempteur, Canada); Dominic Giroux Bernier (Montreal, Canada); Michael James McGinn (Montreal, Canada)
ASSIGNEE(S)	RM Soldier Systems, Ltd. (Wilmington, Delaware)
INVENTOR(S)	Stéphane Lebel (St. Redempteur, Canada); Dominic Giroux Bernier (Montreal, Canada); Michael James McGinn (Montreal, Canada)
ABSTRACT	Systems and methods for selectively attaching an accessory mount to a helmet are disclosed. A carrier may be used to position the accessory mount on the helmet. The accessory mount may be positioned on the helmet without engaging the rim of the helmet. The carrier may be compatible with various accessory mounts to permit mounting of different accessories. The accessory mount may be a powered mount for attachment to a Night Vision Device (NVD) such as Enhanced Night Vision Goggles (ENVG), or the accessory mount may be a non-powered accessory mount.
FILED	Tuesday, July 31, 2012
APPL NO	13/563596
ART UNIT	3732 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Hats; Head Coverings A42B 3/04 (20130101) A42B 3/042 (20130101) Original (OR) Class
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10492723 — Predicting immunotherapy response in non-small cell lung cancer patients with quantitative vessel tortuosity

US 10492723	Madabhushi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Center for Research Resources (NCRR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Anant Madabhushi (Shaker Heights, Ohio); Mehdi Alilou (Cleveland, Ohio); Vamsidhar Velcheti (Pepper Pike, Ohio)
ABSTRACT	Embodiments classify a region of tissue demonstrating non-small cell lung cancer using quantified vessel tortuosity (QVT). One example apparatus includes annotation circuitry configured to segment a lung region from surrounding anatomy in the region of tissue represented in a radiological image and segment a nodule from the lung region by defining a nodule boundary; vascular segmentation circuitry configured to generate a three dimensional (3D) segmented vasculature by segmenting a vessel associated with the nodule, and to identify a center line of the 3D segmented vasculature; QVT feature extraction circuitry configured to extract a set of QVT features from the radiological image; and classification circuitry configured to compute a probability that the region of tissue will respond to immunotherapy and generate a classification that the region of tissue is a responder or a non-responder based, at least in part, on the probability.
FILED	Tuesday, January 30, 2018
APPL NO	15/883649
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/02007 (20130101) A61B 5/4839 (20130101) Original (OR) Class A61B 5/4842 (20130101) A61B 5/4848 (20130101) A61B 5/7264 (20130101) A61B 6/032 (20130101) A61B 6/504 (20130101) A61B 6/5217 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6262 (20130101) G06K 9/6268 (20130101) G06K 2009/00932 (20130101) G06K 2009/6213 (20130101) G06K 2209/051 (20130101) G06K 2209/053 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 7/0016 (20130101) G06T 2207/10081 (20130101) G06T 2207/20081 (20130101) G06T 2207/30064 (20130101) G06T 2207/30101 (20130101) G06T 2207/30172 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/50 (20180101)
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10492744 — System and method for motion-free computed tomography

US 10492744	Gupta et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Rajiv Gupta (Wayland, Massachusetts); Yongjin Sung (Boston, Massachusetts)
ABSTRACT	A system and method for computed tomography (CT) imaging is provided. The system includes a gantry having a first and second circumference defining locations fixed in relation to a subject arranged therein, the first and second circumference being axially separated, and spaced from a central axial plane of the gantry. The system also includes a plurality of source modules arranged at locations along the first circumference, and configured for directing X-ray beams toward the subject using a selected illumination pattern, and a plurality of detector modules arranged at locations along the second circumference, wherein the source and detector modules are angled toward the central axial plane such that each source module is diametrically opposed to one or more detector modules. The system further includes an acquisition system configured for controlling the plurality of source modules in accordance with the selected illumination pattern, and acquiring CT image data from the plurality of detector modules.
FILED	Wednesday, July 08, 2015
APPL NO	15/320616
ART UNIT	2884 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/0407 (20130101) A61B 6/482 (20130101) A61B 6/4007 (20130101) A61B 6/4014 (20130101) Original (OR) Class A61B 6/4241 (20130101) A61B 6/4291 (20130101) A61B 6/4429 (20130101) A61B 6/5205 (20130101) A61B 6/5264 (20130101) A61B 6/5282 (20130101)
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10493142 — Gene optimized Hantaan virus M segment DNA vaccine for hemorrhagic fever with renal syndrome

US 10493142	Schmaljohn
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland)
ASSIGNEE(S)
INVENTOR(S)	Connie Schmaljohn (Middletown, Maryland)
ABSTRACT	A synthetic, codon-optimized Hantaan virus (HTNV) full-length M gene open reading frame that consists of a unique nucleotide sequence encoding HTNV proteins. This synthetic gene was cloned into a plasmid to form the first optimized HTNV full-length M gene that elicits neutralizing antibodies in animals when delivered in combination with a similarly optimized Puumala virus (PUUV) DNA vaccine. The invention obviates the need for an extraneous gene sequence that was previously required for expression of the non-optimized HTNV gene. The synthetic gene is engineered into a molecular vaccine system to prevent hemorrhagic fever with renal syndrome (HFRS) caused by infection with HTNV, SEOV, or DOBV. Alternatively, it can be combined with the optimized PUUV DNA vaccine to protect against HFRS caused by any hantavirus.
FILED	Thursday, April 05, 2018
APPL NO	15/945768
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 9/12 (20130101) A61K 9/0019 (20130101) A61K 9/0021 (20130101) A61K 9/51 (20130101) A61K 9/0073 (20130101) A61K 9/5115 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 39/385 (20130101) A61K 2039/53 (20130101) A61K 2039/70 (20130101) A61K 2039/575 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/12122 (20130101) C12N 2760/12134 (20130101) C12N 2760/12171 (20130101) C12N 2800/22 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 999/99 (20130101)
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10493172 — Gas-filled structures and related compositions, methods and systems to image a target site

US 10493172	Lakshmanan et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Anupama Lakshmanan (Pasadena, California); Arash Farhadi (Pasadena, California); Suchita P. Nety (Sunnyvale, California); Raymond W. Bourdeau (Watertown, Massachusetts); Mikhail Shapiro (Los Angeles, California)
ABSTRACT	Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.
FILED	Friday, June 02, 2017
APPL NO	15/613104
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/481 (20130101) A61B 8/5238 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 49/0045 (20130101) A61K 49/0093 (20130101) A61K 49/221 (20130101) A61K 49/223 (20130101) Original (OR) Class Peptides C07K 14/195 (20130101) C07K 2319/00 (20130101)
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10493179 — Modified silk films containing glycerol

US 10493179	Lu et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Trustees of Tufts College (Medford, Massachusetts)
ASSIGNEE(S)	Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S)	Shenzhou Lu (Suzhou, China PRC); Xiaoqin Wang (Winchester, Massachusetts); Fiorenzo Omenetto (Lexington, Massachusetts); David L. Kaplan (Concord, Massachusetts)
ABSTRACT	The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50% (w/w) glycerol, and are prepared by entirely aqueous processes. The ductile silk film may be further treated by extracting the glycerol from and re-drying the silk film. Active agents may be embedded in or deposited on the glycerol modified silk film for a variety of medical applications. The films may be shaped into 3-dimensional structures, or placed on support surfaces as labels or coatings. The glycerol modified silk films of the present invention are useful in variety of applications such as tissue engineering, medical devices or implants, drug delivery, and edible pharmaceutical or food labels.
FILED	Tuesday, June 30, 2015
APPL NO	14/755215
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/3604 (20130101) Original (OR) Class A61L 27/3804 (20130101) A61L 2420/06 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/30 (20130101) B05D 3/107 (20130101) B05D 3/0254 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/18 (20130101) C08J 5/18 (20130101) C08J 2389/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/053 (20130101) C08K 5/053 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/02 (20130101)
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10493404 — Heat and humidity removal unit for a self-contained breathing apparatus

US 10493404	Pasadilla et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Paragon Space Development Corporation (Tucson, Arizona)
ASSIGNEE(S)	Paragon Space Development Corporation (Tucson, Arizona)
INVENTOR(S)	Patrick Dee Pasadilla (Tucson, Arizona); Chad E. Bower (Littleton, Colorado); Laura Katrina Kelsey (Tucson, Arizona)
ABSTRACT	This disclosure relates to a regenerable, heat-abating, humidity-neutralizing, carbon dioxide removal system for a self-contained breathing apparatus. The self-contained breathing apparatus can include a carbon dioxide removal unit that scrubs carbon dioxide out of exhaled air from a user to provide humidified, scrubbed exhaled air. The self-contained breathing apparatus can further include a heat and humidity removal unit that is configured to receive the humidified, scrubbed exhaled air, and is configured to remove water vapor and heat associated with the water vapor from the humidified, scrubbed exhaled air in order to provide cooled, dehumidified inhalation air. The cooled, dehumidified air can be supplemented with oxygen and returned to the user at a comfortable temperature. In some implementations, the heat and humidity removal unit can replace conventional heat exchange and energy storage units, including heat exchange and energy storage units that use phase change materials.
FILED	Wednesday, November 23, 2016
APPL NO	15/360750
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Devices, Apparatus or Methods for Life-saving A62B 7/10 (20130101) A62B 9/003 (20130101) Separation B01D 53/62 (20130101) Original (OR) Class Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 11/00 (20130101)
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10493455 — Device and method for isolation of corneal endothelial cells

US 10493455	Haggins, Jr. et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Fort Detrick, Maryland)
ASSIGNEE(S)	The Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland)
INVENTOR(S)	Robert Haggins, Jr. (Belcamp, Maryland); Erik Eaton, Jr. (Havre de Grace, Maryland); Zachary Murray (Jarrettsville, Maryland); Timothy Varney (Baltimore, Maryland)
ABSTRACT	An apparatus for isolating corneal endothelial cells (CECs) includes a housing with an interior wall that defines a hollow interior of the housing. At least four fluid channels are formed in the housing with two of the channels terminating in respective openings in an upper portion of the interior wall and two of the channels terminating in respective jets in the upper portion of the interior wall. A convex projection is centrally located on the circular base of the hollow interior and is configured to receive an inverted cornea. A circular insert for the housing has an opening therein in which the convex projection projects when the insert is mated with the lower portion of the interior wall. CECs are harvested from the inverted cornea.
FILED	Friday, October 26, 2018
APPL NO	16/171797
ART UNIT	1799 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 3/502769 (20130101) B01L 2200/0652 (20130101) B01L 2300/14 (20130101) B01L 2300/0877 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101)
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10493524 — Powder metal with attached ceramic nanoparticles

US 10493524	She et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Ying She (East Hartford, Connecticut); John A. Sharon (Manchester, Connecticut); James T. Beals (West Harford, Connecticut); Aaron T. Nardi (East Granby, Connecticut)
ABSTRACT	A method for processing a powder material includes feeding a powder material through an additive processing machine to deposit multiple layers of the powder material onto one another and using an energy beam to thermally fuse selected portions of the layers to one another with reference to data relating to a particular cross-section of an article being formed. The powder material has spherical metal particles and a spaced-apart distribution of ceramic nanoparticles attached to the surfaces of the particles. The ceramic nanoparticles form a dispersion of reinforcement through the formed article.
FILED	Wednesday, August 16, 2017
APPL NO	15/678260
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/02 (20130101) Original (OR) Class B22F 1/02 (20130101) B22F 1/0062 (20130101) B22F 1/0085 (20130101) B22F 1/0085 (20130101) B22F 1/0088 (20130101) B22F 3/1055 (20130101) B22F 2998/10 (20130101) B22F 2998/10 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 15/0086 (20130101) B23K 15/0093 (20130101) B23K 26/0006 (20130101) B23K 26/342 (20151001) B23K 2103/02 (20180801) B23K 2103/08 (20180801) B23K 2103/10 (20180801) B23K 2103/14 (20180801) B23K 2103/52 (20180801) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Alloys C22C 32/0015 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/295 (20151101)
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10494089 — Drive shaft system hanger bearing

US 10494089	Gmirya et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Sikorsky Aircraft Corporation (Stratford, Connecticut)
ASSIGNEE(S)	SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut)
INVENTOR(S)	Yuriy Gmirya (Woodbridge, Connecticut); Rodger W. Bowman (Derby, Connecticut)
ABSTRACT	A hanger bearing assembly for a shaft assembly includes a plurality of bearing elements arranged around a circumference of a shaft assembly, each bearing element having a bearing element diameter. A bearing inner race is positioned between the plurality of bearing elements and the shaft assembly and extends circumferentially about the shaft assembly. The bearing inner race includes an outer wall interactive with the plurality of bearing elements. The outer wall has a linear profile extending in an axial direction. A bearing outer race is positioned radially outboard of the plurality of bearing elements and extends circumferentially about the shaft assembly. The bearing outer race includes an inner surface interactive with the plurality of bearing elements and having a curvilinear inner surface profile extending in the axial direction.
FILED	Monday, March 23, 2015
APPL NO	15/312769
ART UNIT	3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 27/06 (20130101) B64C 27/12 (20130101) Original (OR) Class B64C 27/14 (20130101) B64C 27/82 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 19/06 (20130101) F16C 23/08 (20130101) F16C 23/086 (20130101) F16C 27/066 (20130101)
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10494116 — Heat shield for signature suppression system

US 10494116	Petty, Sr. et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	ROLLS-ROYCE NORTH AMERICAN TECHNOLOGIES INC. (Indianapolis, Indiana)
ASSIGNEE(S)	Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
INVENTOR(S)	Jack D. Petty, Sr. (Indianapolis, Indiana); Colin Faucett (Brownsburg, Indiana); Kenneth M. Pesyna (Carmel, Indiana); James C. Loebig (Greenwood, Indiana)
ABSTRACT	Devices, systems, and methods of a casing for a heat suppression system of a gas turbine engine exhaust include a floating heat shield.
FILED	Thursday, July 27, 2017
APPL NO	15/661611
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/12 (20130101) B64D 33/04 (20130101) Original (OR) Class B64D 2033/045 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/02 (20130101) F01D 25/30 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) F02C 7/24 (20130101) Jet-propulsion Plants F02K 1/822 (20130101) F02K 1/825 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2230/60 (20130101) F05D 2260/31 (20130101) F05D 2260/96 (20130101) F05D 2260/231 (20130101)
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10494272 — Self-regenerating biofilter

US 10494272	Page et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	United States of America as Represented by The Secretary of the Army (Alexandria, Virginia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Alexandria, Virginia)
INVENTOR(S)	Martin Page (Urbana, Illinois); Andrew J. Nelson (Champaign, Illinois); Benjamin C. Masters (Urbana, Illinois)
ABSTRACT	The present invention is a self-regenerating biofilter. The biofilter tank receives untreated water through an intake inlet, filters it through a filtration mass and expels purified water through an output outlet. The filtration mass includes gravel and activated carbon layers separated by a mesh screen. A compressed air line is located below the mesh screen. Periodically, the biofilter self-cleans by opening a flush valve that expels a flush water stream carrying debris. The biofilter self-regenerates by periodically stopping filtration for a time, allowing biological matter left on the activated carbon to degrade into biomass. Periodically, the biofilter removes and flushes out biomass by application of water or a combination of air and water.
FILED	Saturday, March 31, 2018
APPL NO	15/942438
ART UNIT	1778 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 2101/02 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/42 (20130101) C02F 1/283 (20130101) Original (OR) Class C02F 3/006 (20130101) C02F 3/06 (20130101) C02F 3/104 (20130101) C02F 3/106 (20130101) C02F 2003/001 (20130101) C02F 2209/02 (20130101) C02F 2209/006 (20130101) C02F 2209/44 (20130101) C02F 2303/16 (20130101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 10/15 (20150501)
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10494315 — Method for making a novel nanocomposite for combustion applications

US 10494315	Buckner et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Steven Wayne Buckner (St. Louis, Missouri); Paul Jelliss (St. Louis, Missouri); Stephen Chung (Florissant, Missouri); Jacob M Laktas (St. Louis, Missouri); Gregory J Place (St. Louis, Missouri)
ASSIGNEE(S)	SAINT LOUIS UNIVERSITY (Saint Louis, Missouri)
INVENTOR(S)	Steven Wayne Buckner (St. Louis, Missouri); Paul Jelliss (St. Louis, Missouri); Stephen Chung (Florissant, Missouri); Jacob M Laktas (St. Louis, Missouri); Gregory J Place (St. Louis, Missouri)
ABSTRACT	The present invention generally concerns a method for isolating nanoparticles via the decomposition of a ternary metal hydride. More specifically, the present invention harnesses increased energy densities from two distinct nanoparticles isolated by a precise decomposition of LiAlH₄. The singular material is air stable and is a nanocomposite of Li₃AlH₆nanoparticles, elemental Al nanoparticles, an amount of Ti metal, and a nanoscale organic layer, which we call nMx. The nanocomposite protects and preserves the high energy densities of the core metals isolated from the controlled reaction and makes the nanoparticles safe to handle in air. The final composite is devoid of byproducts or phase transitions that will decrease the energy output of the nanocomposite. The method of the present invention creates a narrow distribution of nanoparticles that have unique burning characteristics useful for many applications.
FILED	Monday, August 14, 2017
APPL NO	15/675815
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/08 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 45/32 (20130101) Original (OR) Class Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/81 (20130101) Y10S 977/773 (20130101) Y10S 977/896 (20130101)
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10494479 — Polymeric nanogels with degradable backbones and from GRAS components, and compositions and methods thereof

US 10494479	Thayumanavan et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Sankaran Thayumanavan (Amherst, Massachusetts); Rajasekhar R. Ramireddy (Amherst, Massachusetts)
ABSTRACT	The invention generally relates to novel polymers and polymeric nanogels having biodegradable polymeric backbones, and compositions and methods of preparation and use thereof, for example, as guest-host polymer nano-assemblies and nano-delivery vehicles, which offer utilities in diverse fields including drug delivery, diagnostics and specialty materials.
FILED	Saturday, November 03, 2018
APPL NO	16/179932
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/10 (20130101) C08G 69/26 (20130101) C08G 69/48 (20130101) Original (OR) Class
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10494485 — Branched additives for polymer toughening

US 10494485	Mrozek et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Randy A. Mrozek (Port Deposit, Maryland); Joseph L. Lenhart (Port Deposit, Maryland); Robert H. Lambeth (Elkton, Maryland); Jan W. Andzelm (North East, Maryland)
ABSTRACT	Toughened polymeric materials and methods of forming toughened polymeric materials are provided herein. In some embodiments, a method of forming toughened polymeric materials may include preparing a branched polymeric additive; mixing the branched polymeric additive with a polymer to form a polymeric mixture, wherein the branched polymeric molecule either mixes and/or bonds with the polymer to reduce mobility in the polymer; and curing the polymeric mixture. In some embodiments, a toughened polymeric material comprises a polymer network; and a branched polymeric molecule bonded to the polymer network.
FILED	Monday, November 09, 2015
APPL NO	14/936190
ART UNIT	1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 287/00 (20130101) C08F 299/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/44 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 83/04 (20130101)
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10494738 — Growth of crystalline materials on two-dimensional inert materials

US 10494738	Nepal et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Neeraj Nepal (Woodbridge, Virginia); Virginia Wheeler (Alexandria, Virginia); Charles R. Eddy, Jr. (Columbia, Maryland); Francis J. Kub (Arnold, Maryland); Travis J. Anderson (Alexandria, Virginia); Michael A. Mastro (Fairfax, Virginia); Rachael L. Myers-Ward (Springfield, Virginia); Sandra C. Hangarter (Gaithersburg, Maryland)
ABSTRACT	A method of growing crystalline materials on two-dimensional inert materials comprising functionalizing a surface of a two-dimensional inert material, growing a nucleation layer on the functionalized surface, and growing a crystalline material. A crystalline material grown on a two-dimensional inert material made from the process comprising functionalizing a surface of a two-dimensional inert material, growing a nucleation layer on the functionalized surface, and growing a crystalline material.
FILED	Monday, January 28, 2019
APPL NO	16/258801
ART UNIT	1783 — Miscellaneous Articles, Stock Material
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/183 (20130101) C30B 25/186 (20130101) Original (OR) Class C30B 29/40 (20130101) C30B 29/48 (20130101) C30B 29/406 (20130101)
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10494936 — Fastener retention mechanism

US 10494936	Biolsi et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Department of the Navy (DON) Naval Air Systems Command (NAVAIR)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	David Biolsi (Portland, Maine); Kevin C. Eckland (Kennebunk, Maine); Steven J. Feigleson (Falmouth, Maine); Thomas Freeman (Kennebunk, Maine)
ABSTRACT	A stator assembly having: an inner air seal carrier having a mounting body; a plurality of guide vanes secured to the mounting body via a plurality of fasteners; and a fastener retention mechanism secured to the mounting body via the plurality of fasteners. The fastener retention mechanism having: a housing defining an inner chamber; and a filler located within the inner chamber. The portions of the plurality of fasteners are encapsulated within the filler.
FILED	Monday, May 23, 2016
APPL NO	15/162032
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/041 (20130101) F01D 9/042 (20130101) Original (OR) Class F01D 11/001 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/30 (20130101) F05D 2240/12 (20130101) F05D 2240/80 (20130101) F05D 2260/30 (20130101) F05D 2300/501 (20130101) F05D 2300/615 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101) Y02T 50/673 (20130101)
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10494938 — Gas turbine engine with dove-tailed TOBI vane

US 10494938	Harris
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Meggan Harris (Colchester, Connecticut)
ABSTRACT	A combustor assembly for a gas turbine engine includes a TOBI module which includes a TOBI housing. The TOBI housing has a slot. A vane including a dovetail is removably received within the slot.
FILED	Wednesday, May 28, 2014
APPL NO	14/892138
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/081 (20130101) F01D 5/3007 (20130101) F01D 9/04 (20130101) F01D 9/042 (20130101) F01D 9/065 (20130101) Original (OR) Class F01D 25/12 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/3212 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/676 (20130101)
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10495156 — Lift fan clutch plate for preventing blade tilt

US 10495156	Bouton et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Systems Command (NAVAIR)
APPLICANT(S)	Rolls-Royce Corporation (Indianapolis, Indiana)
ASSIGNEE(S)	ROLLS-ROYCE CORPORATION (Indianapolis, Indiana)
INVENTOR(S)	Matthew Tyler Bouton (Indianapolis, Indiana); Kevin Beckner (Indianapolis, Indiana); Andy Copeland (Greenwood, Indiana); Matt Starr (Indianapolis, Indiana); Doug Schwerin (Zionsville, Indiana); Kyle Hassler (Pittsboro, Indiana)
ABSTRACT	A clutch for a lift fan is configured such that in an engaged position, two output clutch plates are in frictional communication with input clutch plates and a load is transferred from an input shaft to an output shaft via the two output clutch plates, the input clutch plates and an output shaft lug key, and in a disengaged position each of the two output clutch plates are axially displaced from input clutch plate. A metallic clip is coupled to the outer periphery of the output clutch plate. The metallic clip defines a key way in the output clutch plate.
FILED	Monday, March 06, 2017
APPL NO	15/450630
ART UNIT	3659 — Material and Article Handling
CURRENT CPC	Aeroplanes; Helicopters B64C 29/0025 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/10 (20130101) B64D 35/00 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/36 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/90 (20130101) F05D 2260/4023 (20130101) Couplings for Transmitting Rotation; Clutches; Brakes F16D 1/0864 (20130101) F16D 1/0876 (20130101) F16D 13/38 (20130101) Original (OR) Class F16D 13/52 (20130101) F16D 13/69 (20130101) F16D 13/646 (20130101) F16D 13/683 (20130101) F16D 2200/0039 (20130101) F16D 2250/0046 (20130101)
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10495401 — Orthotropic beam truss

US 10495401	Helton
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Justin R. Helton (Fredericksburg, Virginia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Justin R. Helton (Fredericksburg, Virginia)
ABSTRACT	A truss is provided for stiffening a gun barrel on a mount. The truss includes a collet, a plurality of retainers and complementary sets of first and second beams. The collet has corresponding pluralities of corners and faces and an annulus for receiving the gun barrel. The sets of beams correspond to the plurality of retainers. Each beam has proximal and distal ends in relation to the mount. The distal ends of the first beams connect to a corner. The distal ends of the second beams connect to a face. The proximal ends of the first and second beams connect to a respective retainer.
FILED	Wednesday, October 24, 2018
APPL NO	16/169239
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 21/36 (20130101) F41A 23/02 (20130101) Original (OR) Class
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10495425 — Thermoformed projectile cartridge

US 10495425	Shebalin
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	John-Paul Shebalin (Chapel Hill, North Carolina)
ASSIGNEE(S)	United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	John-Paul Shebalin (Chapel Hill, North Carolina)
ABSTRACT	An axisymmetric disk-shaped cartridge is provided for firing from a gun having a fluted bore. The cartridge is initiated by a firing pin and includes a primer core, a propellant charge, a booster charge, a projectile mass, an ablative cap and a ductile metal coating. The projectile mass is disposed over the booster charge while the ablative cap is disposed over the projectile mass. The coating and mass elongate and radially narrow to maintain axial symmetry while being accelerated along the bore.
FILED	Thursday, October 04, 2018
APPL NO	16/151638
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 21/16 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 5/182 (20130101) Original (OR) Class F42B 5/196 (20130101)
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10495464 — Systems and methods for GNSS SNR probabilistic localization and 3-D mapping

US 10495464	Irish et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Andrew T. Irish (San Diego, California); Jason T. Isaacs (Santa Barbara, California); Francois Quitin (Brussels, Belgium); Joao P. Hespanha (Santa Barbara, California); Upamanyu Madhow (Santa Barbara, California)
ABSTRACT	Various embodiments each include at least one of systems, methods, devices, and software for GNSS simultaneous localization and mapping (SLAM). The disclosed techniques demonstrate that simultaneous localization and mapping (SLAM) can be performed using only GNSS SNR and geo-location data, collectively termed GNSS data henceforth. A principled Bayesian approach for doing so is disclosed. A 3-D environment map is decomposed into a grid of binary-state cells (occupancy grid) and the receiver locations are approximated by sets of particles. Using a large number of sparsely sampled GNSS SNR measurements and receiver/satellite coordinates (all available from off-the-shelf GNSS receivers), likelihoods of blockage are associated with every receiver-to-satellite beam. Loopy Belief Propagation is used to estimate the probabilities of each cell being occupied or empty, along with the probability of the particles for each receiver location.
FILED	Tuesday, December 02, 2014
APPL NO	15/038702
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/005 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/22 (20130101)
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10495592 — Use of metal-organic frameworks and metal oxides for sensing chemicals using electrical impedance spectroscopy

US 10495592	Peterson et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Aberdeen Proving Ground (APG) Combat Capabilities Development Command (CCDC) Chemical Biological Center (CCDC CBC) Research, Development and Engineering Command (RDECOM) Edgewood Chemical Biological Center (ECBC)
APPLICANT(S)	U.S. Army Edgewood Chemical Biological Center (APG, Maryland)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Gregory W Peterson (Belcamp, Maryland); Augustus W Fountain, III (Bel Air, Maryland); Jennifer R Soliz (Ellicott City, Maryland); Adam J Hauser (Tuscaloosa, Alabama)
ABSTRACT	Provided are processes for the sensitive detection of the presence of, absence of, and optionally the identity of, one or more chemical agents. The processes use the binding of chemical agents to a metal organic framework or metal oxide/hydroxide electrically connected to a pair of electrodes to detect low levels of chemical in a sample. By exposing the surface of the metal organic framework or the surface of the metal oxide/hydroxide to the chemicals and then measuring changes in impedance magnitude and/or phase shift through electrical impedance spectroscopy, the presence of a chemical agent is readily detected.
FILED	Tuesday, August 29, 2017
APPL NO	15/689664
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/026 (20130101) Original (OR) Class G01N 33/20 (20130101) G01N 33/0037 (20130101) G01N 33/0042 (20130101) G01N 33/0052 (20130101) G01N 33/0054 (20130101) G01N 33/0057 (20130101) G01N 33/227 (20130101)
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10495609 — Ultrasonic inspection technique to assess bond quality in composite structures

US 10495609	Kim et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC)
APPLICANT(S)	The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Yong Min Kim (Torrance, California); Joseph T Case (Hawthorne, California); Shant Kenderian (Pasadena, California)
ABSTRACT	An ultrasonic inspection technique may be used to inspect quality of a bond between thermal protection system (TPS) material and a composite. The technique may include a highly damped transducer emitting an incident wave, which may traverse through thermal protection system (TPS) material and to a back wall of a composite. The incident wave may be of a low frequency signal, and may return a bondline echo and a backwall echo. The bondline echo is returned when the incident wave reaches a bondline and the backwall echo is returned when the incident wave reaches the backwall of the composite. The bondline echo and the backwall echo may be used to generate a waveform to assess the bond quality, revealing possible unbonds or kissing unbonds.
FILED	Tuesday, October 18, 2016
APPL NO	15/296958
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/07 (20130101) G01N 29/11 (20130101) G01N 29/043 (20130101) G01N 29/48 (20130101) G01N 29/069 (20130101) Original (OR) Class G01N 29/4454 (20130101) G01N 2291/012 (20130101) G01N 2291/015 (20130101) G01N 2291/044 (20130101) G01N 2291/0231 (20130101) G01N 2291/267 (20130101) G01N 2291/0289 (20130101)
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10495610 — Fiber optic acoustic emission sensor and apparatus

US 10495610	Cranch
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia)
ASSIGNEE(S)	Geoffrey A. Cranch (Washington, District of Columbia)
INVENTOR(S)	Geoffrey A. Cranch (Fairfax Station, Virginia)
ABSTRACT	A method of monitoring a structure for stresses or cracks. A single mode optical fiber is adhered to a structure. The single mode optical fiber includes a first optical cavity. The first optical cavity includes two fiber Bragg gratings with a distance therebetween. The first optical cavity includes a resonance. A frequency shift of the resonance of the first optical cavity is measured with a frequency discriminator. An acoustic emission from the structure is detected based on the frequency shift.
FILED	Monday, August 14, 2017
APPL NO	15/676098
ART UNIT	2861 — Printing/Measuring and Testing
CURRENT CPC	Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/004 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/14 (20130101) Original (OR) Class G01N 29/262 (20130101) G01N 29/2418 (20130101) G01N 29/2425 (20130101) G01N 2291/014 (20130101) G01N 2291/0258 (20130101)
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10495663 — High aspect-ratio low noise multi-axis accelerometers

US 10495663	Najafi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Khalil Najafi (Ann Arbor, Michigan); Yemin Tang (Ann Arbor, Michigan)
ABSTRACT	The design and fabrication of a multi-axis capacitive accelerometer is presented with sub-μg resolution based on CMOS-compatible fabrication technology that can provide large proof-mass, high-aspect ratio and a large sense electrode area within a smaller footprint that previous accelerometers. In some instances, the device footprint can be reduced by placing the sense electrodes near the top or bottom of the transducer structure such that motion of the transducer causes size of the sense gap to vary in a direction that is parallel with longitudinal axis of the support beam for the transducer structure. An extra mass can also be added to the top of the transducer structure to increase sensitivity.
FILED	Saturday, February 18, 2017
APPL NO	15/436774
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/125 (20130101) G01P 15/135 (20130101) Original (OR) Class G01P 15/0894 (20130101)
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10495664 — Dynamic self-calibration of an accelerometer system

US 10495664	Stewart et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Robert E. Stewart (Woodland Hills, California); Michael D. Bulatowicz (Sun Prairie, Wisconsin)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Robert E. Stewart (Woodland Hills, California); Michael D. Bulatowicz (Sun Prairie, Wisconsin)
ABSTRACT	One embodiment includes a method for dynamic self-calibration of an accelerometer system. The method includes forcing a proof-mass associated with a sensor of the accelerometer system in a first direction to a first predetermined position and obtaining a first measurement associated with the sensor in the first predetermined position via at least one force/detection element of the sensor. The method also includes forcing the proof-mass to a second predetermined position and obtaining a second measurement associated with the sensor in the second predetermined position via the at least one force/detection element of the sensor. The method further includes calibrating the accelerometer system based on the first and second measurements.
FILED	Tuesday, October 09, 2018
APPL NO	16/155529
ART UNIT	2861 — Printing/Measuring and Testing
CURRENT CPC	Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/125 (20130101) G01P 15/131 (20130101) G01P 21/00 (20130101) Original (OR) Class G01P 2015/084 (20130101) G01P 2015/0828 (20130101) G01P 2015/0831 (20130101)
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10495665 — Methods, devices and systems for scanning tunneling microscopy control system design

US 10495665	Moheimani et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Seyed Omid Reza Moheimani (Allen, Texas); Farid Tajaddodianfar (Dallas, Texas); Ehud Fuchs (Plano, Texas); John Randall (Richardson, Texas); Joshua Ballard (Richardson, Texas); James Owen (Garland, Texas)
ASSIGNEE(S)	Zyvex Labs, LLC (Richardson, Texas); Texas and Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Seyed Omid Reza Moheimani (Allen, Texas); Farid Tajaddodianfar (Dallas, Texas); Ehud Fuchs (Plano, Texas); John Randall (Richardson, Texas); Joshua Ballard (Richardson, Texas); James Owen (Garland, Texas)
ABSTRACT	Methods, devices, and systems for controlling a scanning tunneling microscope system are provided. In some embodiments, the methods, devices, and systems of the present disclosure utilize a control system included in or added to a scanning tunneling microscope (STM) to receive data characterizing a tunneling current between a tip of the scanning tunneling microscope system and a sample, to estimate, in real-time, a work function associated with the scanning tunneling microscope system, and to adjust, by a control system, a position of the tip based on an estimated work function. Associated systems are described herein.
FILED	Monday, September 18, 2017
APPL NO	15/707738
ART UNIT	2881 — Optics
CURRENT CPC	Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 10/065 (20130101) Original (OR) Class G01Q 60/10 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/042 (20130101) G05B 2219/45182 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 3/1409 (20130101) G05D 3/1454 (20130101) G05D 3/1463 (20130101)
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10495703 — Systems, apparatus, and methods of nonlinear terahertz (THz) magnetic resonance measurement

US 10495703	Hwang et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Harold Young Hwang (Cambridge, Massachusetts); Jian Lu (Medford, Massachusetts); Yaqing Zhang (Cambridge, Massachusetts); Benjamin K. Ofori-Okai (Cambridge, Massachusetts); Keith A. Nelson (Newton, Massachusetts); Xian Li (Cambridge, Massachusetts)
ABSTRACT	A nonlinear terahertz (THz) spectroscopy technique uses a sample illuminated by two THz pulses separately. The illumination generates two signals B_Aand B_B, corresponding to the first and second THz pulse, respectively, after interaction with the sample. The interaction includes excitation of at least one ESR transition in the sample. The sample is also illuminated by the two THz pulses together, with an inter-pulse delay τ, generating a third signal B_AB. A nonlinear signal BNL is then derived via B_NL=B_AB−B_A−B_B. This nonlinear signal B_NLcan be then processed (e.g., Fourier transform) to study the properties of the sample.
FILED	Friday, March 09, 2018
APPL NO	15/917198
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/10 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) Original (OR) Class G01R 33/60 (20130101) G01R 33/323 (20130101)
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10495727 — Phase difference estimator and method for estimating a phase difference between signals

US 10495727	Gunn et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Life Cycle Management Center (AFLCMC)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Brian A. Gunn (Goleta, California); Bruce A. Jensen (Goleta, California)
ABSTRACT	Embodiments of a phase difference estimator and method are generally described herein. The phase difference estimator includes a delay element to delay a reference clock signal that includes an alternating symbol waveform by one of a plurality of delay values. The phase difference estimator further includes a sampler to sample a monitored clock signal provided by a second device responsive to edges of the delayed reference clock signal to generate a sampled signal output. The phase difference estimator further includes a correlation element to correlate the sampled signal output of the sampler with a step function to generate a correlation value for each delay value, and a controller to instruct the delay element to delay the reference clock signal by one of the delay values and provide a phase difference estimate output indicative of a phase difference between the reference and monitored clock signals based on the correlation value.
FILED	Tuesday, February 07, 2017
APPL NO	15/426193
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/06 (20130101) G01S 5/0221 (20130101) G01S 7/021 (20130101) Original (OR) Class G01S 7/2813 (20130101) G01S 11/02 (20130101) Demodulation or Transference of Modulation From One Carrier to Another H03D 13/00 (20130101)
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10495759 — GPS spoofing detection techniques

US 10495759	Leibner et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) National Security Engineering Center (NSEC) Federally Funded Research and Development Center (FFRDC) Operated by MITRE Corporation (MITRE) at Bedford, MA
APPLICANT(S)	The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S)	The Mitre Corporation (McLean, Virginia)
INVENTOR(S)	Darrow Paine Leibner (Arlington, Virginia); Erik T. Lundberg (McLean, Virginia)
ABSTRACT	Disclosed herein are system, method, and computer program product embodiments for detecting spoofing of a navigation device. A plurality of anti-spoofing techniques are provided. The plurality of anti-spoofing techniques detect interference with data provided by one or more navigation devices for a plurality of threat situations. Positioning, timing and frequency characteristics associated with the one or more navigation devices are analyzed in order to identify a threat situation among the plurality of threat situations. Based on the identified threat situation one or more of the anti-spoofing techniques are executed. The one or more anti-spoofing techniques can be executed in parallel in order to provide various anti-spoofing detection techniques at the same time.
FILED	Thursday, February 13, 2014
APPL NO	14/179607
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/215 (20130101) Original (OR) Class Secret Communication; Jamming of Communication H04K 3/65 (20130101) H04K 3/90 (20130101) H04K 3/224 (20130101) H04K 3/255 (20130101)
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10495766 — Optoelectronic neutron detector

US 10495766	Clarke
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Defense Threat Reduction Agency (DTRA)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Roy Clarke (Ann Arbor, Michigan)
ABSTRACT	An optoelectronic neutron detector and method for detecting nuclear material having a neutron capture and scatter medium receiving neutrons and producing secondary charged particles, a photodetector detecting emitted light from the secondary charged particles and outputting a detector signal, and a controller receiving the detector signal and providing an alert or quantitative indication of detected nuclear material in response to the detector signal.
FILED	Friday, August 21, 2015
APPL NO	15/504834
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Nuclear or X-radiation G01T 1/22 (20130101) G01T 3/00 (20130101) G01T 3/06 (20130101) Original (OR) Class G01T 3/08 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/0091 (20130101)
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10495829 — Positioning of an optical beam to mitigate hysteresis

US 10495829	Squires
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Air Force (Kirtland AFB, New Mexico)
ASSIGNEE(S)	THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (Washington, District of Columbia)
INVENTOR(S)	Matthew Squires (Sandia Park, New Mexico)
ABSTRACT	A device for the positioning of an optical beam includes a housing and at least four prisms aligned for passing the optical beam therethrough, where each of the at least four prisms is movable relative to the housing. The device may also include one or more positioners engaged with the at least four prisms, the one or more positioners controllable to move the at least four prisms, where movement of the at least four prisms adjusts a position and an angle of the optical beam passed therethrough relative to an x-y plane.
FILED	Monday, February 26, 2018
APPL NO	15/904695
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/4206 (20130101) G02B 6/4225 (20130101) Original (OR) Class
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10496094 — Systems and methods for ground plane estimation

US 10496094	Blankespoor et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Boston Dynamics, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	Boston Dynamics, Inc. (Waltham, Massachusetts)
INVENTOR(S)	Kevin Blankespoor (Arlington, Massachusetts); Gabriel Nelson (Waltham, Massachusetts); Neil Neville (Waltham, Massachusetts)
ABSTRACT	A method for estimating a ground plane includes receiving a pose of a robotic device with respect to a gravity aligned reference frame, receiving one or more locations of one or more corresponding contact points between the robotic device and a ground surface, and determining a ground plane estimation of the ground surface based on the orientation of the robotic device with respect to the gravity aligned reference frame and the one or more locations of one or more corresponding contact points between the robotic device and the ground surface. The ground plane estimation includes a ground surface contour approximation. The method further includes determining a distance between a body of the robotic device and the determined ground plane estimation and causing adjustment of the pose of the robotic device with respect to the ground surface based on the determined distance and the determined ground plane estimation.
FILED	Tuesday, October 03, 2017
APPL NO	15/723881
ART UNIT	3667 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Manipulators; Chambers Provided With Manipulation Devices B25J 9/1615 (20130101) B25J 9/1694 (20130101) B25J 9/1697 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) Original (OR) Class Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/01 (20130101)
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10496095 — Autonomous agent scheduling

US 10496095	Bays et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	United States of America as Represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Matthew J. Bays (Panama City, Florida); Thomas A. Wettergren (Panama City, Florida)
ABSTRACT	Methods are provided to obtain task allocation, planning, and scheduling necessary to ensure service agents can accomplish their tasks efficiently, while transport agents perform the necessary transport and refueling operations. The methods take a scheduling-centric approach, formally incorporate fuel constraints, and are generalized for an arbitrary number of service agents and transport agents. The methods provide for the formal definition of the novel simple agent transport problem, the unique modeling and constraint-based logic required for the docking, transport, and deployment of service agents and the resulting analysis. Tasks to be completed consist of a set of locations, and the agents must service each location set. The methods and systems incorporate Bayes risk to schedule slips and to the application of service agent-transport agent scheduling.
FILED	Tuesday, November 07, 2017
APPL NO	15/806131
ART UNIT	3661 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/001 (20130101) B63G 2008/004 (20130101) B63G 2008/005 (20130101) Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/126 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) Original (OR) Class G05D 1/104 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06316 (20130101) G06Q 50/30 (20130101)
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10496376 — Random number generator

US 10496376	Clark et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute Of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Harry R. Clark (Townsend, Massachusetts); Theodore M. Lyszczarz (Concord, New Hampshire)
ABSTRACT	A novel system for generating random numbers is disclosed. The radioactive source emits photons, which causes the release of electrons on the surface of the detector. The detector is configured as a two dimensional array having a plurality of pixels. This release of electrons creates a splatter pattern on the detector, which is then read by the processor. Subsequent photon emissions create a second splatter pattern, which is then read by the processor. The processor compares these two splatter patterns, and generates random numbers based on these two splatter patterns. In certain embodiments, the processor creates a difference matrix which represents a comparison of the two splatter patterns. The processor then classifies each pixel in the difference matrix in accordance with certain rules. In certain embodiments, these classification rules may vary as a function of time or as a function of where on the detector the pixel is disposed.
FILED	Friday, April 21, 2017
APPL NO	15/493832
ART UNIT	2884 — Optics
CURRENT CPC	Electric Digital Data Processing G06F 7/588 (20130101) Original (OR) Class
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10496439 — Finite resource allocator with intrinsically subordinate operating system

US 10496439	Dickson et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Space Sciences Corporation (Lemitar, New Mexico)
ASSIGNEE(S)	Space Sciences Corporation (Lemitar, New Mexico)
INVENTOR(S)	Lawrence J. Dickson (National City, California); Robert M. Fryer (Solana Beach, California); Lindsay O. Quarrie (Socorro, New Mexico)
ABSTRACT	A method and apparatus for “ring fencing” an operating system, with any apps or programs running on that operating system, in such a way that all operations of the apps, programs, and operating system use real resources only with the permission or through the intermediation of a resource allocator programmed to allow only secure access to a known finite set of resources. The list of kinds of resources is short, and the list of resources is under the explicit control of the resource allocator, which is programmed with Communicating Sequential Processes techniques so as to give formally verifiable assurance of predefined security requirements. At the same time, the full features of the operating system are supported with minimal changes in its kernel and no changes in app or program binary code that accesses real resources via calls or bytecode that drives dynamic system libraries or a runtime environment.
FILED	Thursday, October 26, 2017
APPL NO	15/795137
ART UNIT	2196 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 9/50 (20130101) Original (OR) Class G06F 9/455 (20130101) G06F 9/505 (20130101) G06F 9/4881 (20130101) G06F 9/5027 (20130101) G06F 9/5061 (20130101) G06F 9/5066 (20130101) G06F 9/5077 (20130101) G06F 9/45533 (20130101) G06F 9/45541 (20130101) G06F 9/45558 (20130101) G06F 21/629 (20130101) G06F 2009/45579 (20130101) G06F 2009/45583 (20130101) G06F 2009/45595 (20130101)
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10496552 — Trusted computing system with enhanced memory

US 10496552	Narayanasamy et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Massachusetts)
INVENTOR(S)	Satish Narayanasamy (Ann Arbor, Michigan); Shaizeen Aga (Ann Arbor, Michigan)
ABSTRACT	A system that executes private enclave functions in a secure high-performance host processor connected to an enhanced memory unit through a conventional memory bus using a packetized interface is disclosed. The logic layer of the enhanced memory unit is included in a trusted computing base (TCB) and is used to implement cryptographic functions. Storage layers of the enhanced memory unit remain outside the TCB and are used to store encrypted data and associated meta-data.
FILED	Wednesday, April 12, 2017
APPL NO	15/485860
ART UNIT	2491 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 12/1408 (20130101) Original (OR) Class G06F 13/16 (20130101) G06F 13/4068 (20130101) G06F 13/4282 (20130101) G06F 21/602 (20130101) G06F 2212/402 (20130101) G06F 2212/1052 (20130101)
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10496574 — Processors, methods, and systems for a memory fence in a configurable spatial accelerator

US 10496574	Fleming et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)	Intel Corporation (Santa Clara, California)
INVENTOR(S)	Kermin Fleming (Hudson, Massachusetts); Kent D. Glossop (Merrimack, New Hampshire); Simon C. Steely, Jr. (Hudson, New Hampshire)
ABSTRACT	Systems, methods, and apparatuses relating to a memory fence mechanism in a configurable spatial accelerator are described. In one embodiment, a processor includes a plurality of processing elements and an interconnect network between the plurality of processing elements to receive an input of a dataflow graph comprising a plurality of nodes, wherein the dataflow graph is to be overlaid into the interconnect network and the plurality of processing elements with each node represented as a dataflow operator in the plurality of processing elements, and the plurality of processing elements are to perform a plurality of operations, each by a respective, incoming operand set arriving at each of the dataflow operators of the plurality of processing elements. The processor also includes a fence manager to manage a memory fence between a first operation and a second operation of the plurality of operations.
FILED	Thursday, September 28, 2017
APPL NO	15/719285
ART UNIT	2184 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 12/0811 (20130101) G06F 12/0813 (20130101) G06F 13/28 (20130101) Original (OR) Class G06F 2212/283 (20130101) G06F 2212/621 (20130101)
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10496701 — Systems and methods for video archive and data extraction

US 10496701	Abeloe et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Warfare Center (NAWC)
APPLICANT(S)	INTEGRITY APPLICATIONS INCORPORATED (Carlsbad, California)
ASSIGNEE(S)	Centauri, LLC (Chantilly, Virginia)
INVENTOR(S)	Kenneth A. Abeloe (Carlsbad, California); Dennis Hsu (San Diego, California)
ABSTRACT	Systems and methods for full motion video search are provided. In one aspect, a method includes receiving one or more search terms. The search terms include one or more of a characterization of the amount of man-made features in a video image and a characterization of the amount of natural features in the video image. The method further includes searching a full motion video database based on the one or more search terms.
FILED	Friday, July 21, 2017
APPL NO	15/656496
ART UNIT	2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Electric Digital Data Processing G06F 16/113 (20190101) G06F 16/783 (20190101) G06F 16/7837 (20190101) G06F 16/7847 (20190101) G06F 16/7867 (20190101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00637 (20130101) G06K 9/00718 (20130101)
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10496710 — Online data management system

US 10496710	Wei
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Jerome H. Wei (La Habra, California)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Jerome H. Wei (La Habra, California)
ABSTRACT	An online data management (ODM) system can be configured to parse tool data for a particular project provided from a plurality of disparate software tools employed for project management. The ODM system can also be configured to generate a data structure based on the tool data, wherein the data structure comprises a hierarchy of interconnected objects. The ODM system can further be configured to identify relationships between objects of the data structure.
FILED	Wednesday, April 29, 2015
APPL NO	14/699701
ART UNIT	2152 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 8/37 (20130101) G06F 8/315 (20130101) G06F 16/245 (20190101) G06F 16/284 (20190101) G06F 16/289 (20190101) G06F 16/951 (20190101) Original (OR) Class G06F 16/9024 (20190101)
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10496932 — Compact RF driver for Paul traps used in quantum computers and methods of making and using same

US 10496932	Kim et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Jungsang Kim (Chapel Hill, North Carolina); Geert Vrijsen (Durham, North Carolina); Robert Spivey (Durham, North Carolina)
ABSTRACT	Aspects of the present disclosure describe a compact RF driver circuit for Paul traps in trapped ion quantum computers and methods, and structures including same.
FILED	Wednesday, July 18, 2018
APPL NO	16/039186
ART UNIT	2881 — Optics
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/4225 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/38 (20130101) Pulse Technique H03K 3/38 (20130101)
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10497117 — Automated percentage of breast density measurements for full field digital mammography

US 10497117	Heine et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (Rochester, Minnesota)
ASSIGNEE(S)	H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida); Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
INVENTOR(S)	John J. Heine (New Port Richey, Florida); Thomas A. Sellers (Tampa, Florida); Celine M. Vachon (Rochester, Minnesota); Erin E. Fowler (Tampa, Florida)
ABSTRACT	An automated percentage of breast density measure (PDa) that analyzes signal dependent noise (SDN) based on a wavelet expansion using full field digital mammography (FFDM). A matched case-control dataset is used with images acquired from a specific direct x-ray capture FFDM system. PDa is applied to the raw and clinical display representation images. Transforming (pixel mapping) of the raw image to another representation (raw-transformed) is performed using differential evolution optimization and investigated the influence of lowering the native spatial resolution of the image by a one-half. When controlling for body mass index, the quartile specific ORs for the associations of PDa with breast cancer varied with representation and resolution. PDa is a valid automated breast density measurement for a specific FFDM technology and compares well against PD (operator-assisted or the standard) when applied to either the raw-transformed or clinical display images from this FFDM technology.
FILED	Thursday, May 24, 2018
APPL NO	15/988143
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/502 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0051 (20130101) G06K 9/527 (20130101) G06K 9/623 (20130101) G06K 2209/05 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/41 (20170101) G06T 2207/10116 (20130101) G06T 2207/20076 (20130101) G06T 2207/30068 (20130101)
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10497530 — Thermionic tungsten/scandate cathodes and methods of making the same

US 10497530	Feigelson et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Boris N. Feigelson (Springfield, Virginia); James A. Wollmershauser (Alexandria, Virginia); Kedar Manandhar (Alexandria, Virginia)
ABSTRACT	A thermionic dispenser cathode having a refractory metal matrix with scandium and barium compounds in contact with the metal matrix and methods for forming the same. The invention utilizes atomic layer deposition (ALD) to form a nanoscale, uniform, conformal distribution of a scandium compound on tungsten surfaces and further utilizes in situ high pressure consolidation/impregnation to enhance impregnation of a BaO—CaO—Al₂O₃based emissive mixture into the scandate-coated tungsten matrix or to sinter a tungsten/scandate/barium composite structure. The result is a tungsten-scandate thermionic cathode having improved emission.
FILED	Friday, April 08, 2016
APPL NO	15/093853
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/02 (20130101) B22F 2998/10 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 1/144 (20130101) H01J 1/146 (20130101) H01J 9/042 (20130101) Original (OR) Class
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10497817 — P-n diodes and p-n-p heterojunction bipolar transistors with diamond collectors and current tunneling layers

US 10497817	Ma
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	Zhenqiang Ma (Middleton, Wisconsin)
ABSTRACT	P-N diodes that include p-type doped diamond and devices, such as p-n-p heterojunction bipolar transistors, that incorporate the p-n diodes are provided. In the p-n diodes, the diamond at the p-n junction has a positive electron affinity and is passivated by a thin layer of inorganic material that provides a tunneling layer that passivates the bonding interface states, without hindering carrier transport across the interface.
FILED	Monday, July 09, 2018
APPL NO	16/029811
ART UNIT	2897 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0259 (20130101) H01L 21/0262 (20130101) H01L 21/02488 (20130101) H01L 21/02527 (20130101) H01L 21/02546 (20130101) H01L 29/45 (20130101) H01L 29/88 (20130101) Original (OR) Class H01L 29/205 (20130101) H01L 29/267 (20130101) H01L 29/0665 (20130101) H01L 29/0821 (20130101) H01L 29/1004 (20130101) H01L 29/1602 (20130101) H01L 29/6603 (20130101) H01L 29/7378 (20130101) H01L 29/8613 (20130101) H01L 29/66037 (20130101)
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10497829 — Semiconductor material doping

US 10497829	Shatalov et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Sensor Electronic Technology, Inc. (Columbia, South Carolina)
ASSIGNEE(S)	Sensor Electronic Technology, Inc. (Columbia, South Carolina)
INVENTOR(S)	Maxim S. Shatalov (Columbia, South Carolina); Remigijua Gaska (Columbia, South Carolina); Jinwei Yang (Columbia, South Carolina); Michael Shur (Vienna, Virginia); Alexander Dobrinsky (Silver Spring, Maryland)
ABSTRACT	A solution for designing and/or fabricating a structure including a quantum well and an adjacent barrier is provided. A target band discontinuity between the quantum well and the adjacent barrier is selected to coincide with an activation energy of a dopant for the quantum well and/or barrier. For example, a target valence band discontinuity can be selected such that a dopant energy level of a dopant in the adjacent barrier coincides with a valence energy band edge for the quantum well and/or a ground state energy for free carriers in a valence energy band for the quantum well. Additionally, a target doping level for the quantum well and/or adjacent barrier can be selected to facilitate a real space transfer of holes across the barrier. The quantum well and the adjacent barrier can be formed such that the actual band discontinuity and/or actual doping level(s) correspond to the relevant target(s).
FILED	Thursday, December 28, 2017
APPL NO	15/856596
ART UNIT	2814 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 20/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/15 (20130101) H01L 29/155 (20130101) H01L 29/201 (20130101) H01L 29/207 (20130101) H01L 29/2003 (20130101) H01L 33/04 (20130101) H01L 33/06 (20130101) Original (OR) Class H01L 33/32 (20130101) H01L 33/0075 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/2009 (20130101) H01S 5/3211 (20130101) H01S 5/3216 (20130101) H01S 5/3407 (20130101) H01S 5/34333 (20130101)
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10497939 — Cation-conductive conformal ultrathin polymer electrolytes

US 10497939	Sassin et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Megan B. Sassin (Alexandria, Virginia); Jeffrey W. Long (Alexandria, Virginia); Debra R. Rolison (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Megan B. Sassin (Alexandria, Virginia); Jeffrey W. Long (Alexandria, Virginia); Debra R. Rolison (Arlington, Virginia)
ABSTRACT	A composite having an electrically conductive substrate and a polymer derived from a vinyl-containing siloxane monomer coating on the substrate. A method of electropolymerizing a vinyl-containing siloxane monomer to form a coating on an electrically conductive substrate.
FILED	Wednesday, October 29, 2014
APPL NO	14/527058
ART UNIT	1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/66 (20130101) H01M 4/366 (20130101) H01M 4/0466 (20130101) H01M 4/622 (20130101) H01M 4/624 (20130101) Original (OR) Class
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10497970 — Alkali ion conducting plastic crystals

US 10497970	Angell et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	Charles Austen Angell (Mesa, Arizona); Iolanda Santana Klein (Tempe, Arizona); Telpriore Greg Tucker (Phoenix, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Charles Austen Angell (Mesa, Arizona); Iolanda Santana Klein (Tempe, Arizona); Telpriore Greg Tucker (Phoenix, Arizona)
ABSTRACT	A solid electrolyte represented by general formula Li_ySiR_x(MO₄), where x is an integer from 1 to 3 inclusive, y=4−x, each R present is independently C1-C3 alkyl or C1-C3 alkoxy, and M is sulfur, selenium, or tellurium. Methods of making the solid electrolyte include combining a phenylsilane and a first acid to yield mixture including benzene and a second acid, and combining at least one of an alkali halide, and alkali amide, and an alkali alkoxide with the second acid to yield a product d represented by general formula Li_ySiR_x(MO₄)_y. The second acid may be in the form of a liquid or a solid. The phenylsilane includes at least one C1-C3 alkyl substituent or at least one C1-C3 alkoxy substituent, and the first acid includes at least one of sulfuric acid, selenic acid, and telluric acid.
FILED	Friday, June 29, 2018
APPL NO	16/023959
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/025 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/056 (20130101) H01M 10/0525 (20130101) H01M 10/0561 (20130101) H01M 10/0562 (20130101) H01M 10/0564 (20130101) Original (OR) Class H01M 2300/006 (20130101) H01M 2300/0065 (20130101) H01M 2300/0068 (20130101) H01M 2300/0091 (20130101)
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10498015 — Method of making arbitrarily-shaped multifunctional structure

US 10498015	Handy et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC)
APPLICANT(S)	SI2 Technologies, Inc. (North Billerica, Massachusetts)
ASSIGNEE(S)	SI2 Technologies, Inc. (North Billerica, Massachusetts)
INVENTOR(S)	Erik S. Handy (Malden, Massachusetts); Joseph Michael Kunze (Chelmsford, Massachusetts)
ABSTRACT	Multifunctional structures and methods of manufacturing multifunctional structures which function as both electronic devices and load-bearing elements are disclosed. The load-bearing elements are designed to have electronic functionality using electronics designed to be load-bearing. The method of manufacturing the multifunctional structure comprises forming an electronic element directly on at least one ply of arbitrarily shaped load-bearing material using conventional lithographic techniques and/or direct write fabrication techniques, and assembling at least two plies of arbitrarily shaped load-bearing material into a multifunctional structure. The multifunctional structure may be part of an aerospace structure, part of a land vehicle, pan of a watercraft or part of a spacecraft.
FILED	Wednesday, April 12, 2017
APPL NO	15/486152
ART UNIT	3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/27 (20130101) H01Q 1/28 (20130101) Original (OR) Class H01Q 21/065 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49016 (20150115)
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10498017 — Miniature ultra-wideband multifunctional antennas and related techniques

US 10498017	Ouedraogo et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Raoul Ouatagom Ouedraogo (Lexington, Massachusetts); Eric Phelps (Bedford, Massachusetts); Jeremy Muldavin (Lawrence, Massachusetts); Todd Addison Thorsen (Carlisle, Massachusetts); Carl O. Bozler (Waltham, Massachusetts); Christopher Cherry (Westford, Massachusetts)
ABSTRACT	Miniature multifunctional antennas and related techniques are disclosed that are capable of wide bandwidth operation. In some embodiments, the antennas are capable of being reconfigured in the field for optimal performance in different frequency band configurations (e.g., a single wide instantaneous bandwidth, multiple smaller bands, etc.) and/or for purposes of self healing. In some embodiments, the antennas can be reconfigured in the field to achieve different polarizations (e.g., vertical, horizontal, circular). The antennas can be implemented in a very compact manner making them ideal for use in devices and platforms where size and weight are a concern.
FILED	Tuesday, September 15, 2015
APPL NO	15/302053
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0837 (20130101) Antennas, i.e Radio Aerials H01Q 1/36 (20130101) Original (OR) Class H01Q 3/01 (20130101) H01Q 9/28 (20130101) H01Q 9/0457 (20130101) H01Q 21/26 (20130101) H01Q 21/065 (20130101) H01Q 25/002 (20130101)
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10498208 — Lightweight return flux alternator

US 10498208	Kebabian et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Aerodyne Research, Inc. (Billerica, Massachusetts)
ASSIGNEE(S)	Aerodyne Research, Inc. (Billerica, Massachusetts)
INVENTOR(S)	Paul L. Kebabian (Acton, Massachusetts); Kurt D. Annen (Rowley, Massachusetts); Richard N. Jorgenson (Amherst, New Hampshire)
ABSTRACT	In one embodiment, a return flux linear alternator employs a magnet assembly that includes a pair of permanent ring magnets with opposing polarity and a pair of air gaps. The additional permanent ring and air gap complete a magnetic flux loop of the alternator rather than the magnet pole, as in traditional designs. An alternator coil assembly includes a pair of oppositely wound coil sections that each linearly move through a respective one of the pair of air gaps. In addition, the return flux linear alternator may employ a variety of structures to increase mechanical strength, including a reinforcement fabric, and a variety of structures to increase electrical efficiency, including a thermally conductive but electrically nonconductive spacer between the coil sections and multiple pairs of electrical leads.
FILED	Tuesday, December 20, 2016
APPL NO	15/384965
ART UNIT	2838 — Electrical Circuits and Systems
CURRENT CPC	Internal-combustion Piston Engines; Combustion Engines in General F02B 63/041 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/021 (20130101) Dynamo-electric Machines H02K 1/02 (20130101) H02K 5/02 (20130101) H02K 7/1884 (20130101) H02K 35/04 (20130101) Original (OR) Class
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10498341 — Sparse coding with memristor networks

US 10498341	Lu et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Regents of The University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Wei Lu (Ann Arbor, Michigan); Fuxi Cai (Ann Arbor, Michigan); Patrick Sheridan (Ann Arbor, Michigan); Chao Du (Ann Arbor, Michigan)
ABSTRACT	Sparse representation of information performs powerful feature extraction on high-dimensional data and is of interest for applications in signal processing, machine vision, object recognition, and neurobiology. Sparse coding is a mechanism by which biological neural systems can efficiently process complex sensory data while consuming very little power. Sparse coding algorithms in a bio-inspired approach can be implemented in a crossbar array of memristors (resistive memory devices). This network enables efficient implementation of pattern matching and lateral neuron inhibition, allowing input data to be sparsely encoded using neuron activities and stored dictionary elements. The reconstructed input can be obtained by performing a backward pass through the same crossbar matrix using the neuron activity vector as input. Different dictionary sets can be trained and stored in the same system, depending on the nature of the input signals. Using the sparse coding algorithm, natural image processing is performed based on a learned dictionary.
FILED	Friday, December 28, 2018
APPL NO	16/235115
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Static Stores G11C 13/0007 (20130101) G11C 13/0069 (20130101) G11C 2213/77 (20130101) Pulse Technique H03K 19/17748 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 49/101 (20130101) Selecting H04Q 3/0004 (20130101) H04Q 11/00 (20130101)
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10498342 — Discretely assembled logic blocks

US 10498342	Langford et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	William Kai Langford (Cambridge, Massachusetts); Amanda Ghassaei (Cambridge, Massachusetts); Neil Gershenfeld (Cambride, Massachusetts)
ABSTRACT	A system and method for producing discretely assembled logic blocks where the logic block assemblies are a 3-dimensional representation of the normal digital design hierarchy. The blocks contain embedded logical functions that are built up from only a few basic 2-dimensional parts that are assembled into a 3-dimensional structure that realizes a particular logic or computing element. These structures can be combined to produce more complex digital structures and even processors. The two basic structural parts are a node and a strut with the strut typically including an embedded logic function. These are combined to produce spatially distributed structures.
FILED	Monday, October 15, 2018
APPL NO	16/159835
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Pulse Technique H03K 3/037 (20130101) H03K 19/20 (20130101) H03K 19/21 (20130101) Original (OR) Class
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10498470 — Relativistic wireless channel emulator

US 10498470	Coleman et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Sea Systems Command (NAVSEA) Johns Hopkins University Applied Physics Laboratory (JH APL)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	David M. Coleman (Baltimore, Maryland); Daniel W. Chew (Charleston, West Virginia); William D. Kight, Jr. (Columbia, Maryland); Daniel R. Barcklow (Odenton, Maryland); Stephan D. Frisbie (Baltimore, Maryland)
ABSTRACT	A channel propagation emulator includes a radio peripheral configured to receive input radio frequency (RF) data and modify the input RF data according to channel effects including signal delay, propagation loss and Doppler shift effect to generate an RF output, and a host device operably coupled to the radio peripheral. The RF output represents a modification of the input RF data based on a propagation model. The host device operably coupled to an external controller and is configured to define emulation parameters based on the propagation model. The propagation model is selected at the external controller. The external controller is configured to provide instructions for implementing the Doppler shift effect to include spreading that is multiplicative in frequency.
FILED	Thursday, June 01, 2017
APPL NO	15/610652
ART UNIT	2648 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Transmission H04B 7/086 (20130101) H04B 7/0617 (20130101) H04B 17/12 (20150115) H04B 17/30 (20150115) Original (OR) Class Selecting H04Q 3/38 (20130101) Wireless Communication Networks H04W 24/00 (20130101)
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10499541 — Cold plate device for a two-phase cooling system

US 10499541	Chainer et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Timothy Joseph Chainer (Putnam Valley, New York); Pritish Ranjan Parida (Stamford, Connecticut); Fanghao Yang (Somerset, New Jersey)
ABSTRACT	Techniques that facilitate two-phase liquid cooling of an electronic device are provided. In one example, an apparatus, such as a cold plate device, comprises a first stackable layer and a second stackable layer. The first stackable layer comprises a first channel formed within the first stackable layer. The first channel comprises a first channel width and the first channel receives a coolant fluid via an inlet port of the apparatus. The second stackable layer comprises a second channel that provides a path for the coolant fluid to flow between the first channel and an outlet port of the apparatus. A width of the second channel increases along a flow direction of the coolant fluid that flows between the inlet port and the outlet port.
FILED	Thursday, March 29, 2018
APPL NO	15/940088
ART UNIT	2835 — Electrical Circuits and Systems
CURRENT CPC	Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 3/12 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/4882 (20130101) H01L 23/473 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20254 (20130101) Original (OR) Class H05K 7/20272 (20130101)
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10499543 — Two-phase liquid cooled electronics

US 10499543	Chainer et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSTNESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Timothy Joseph Chainer (Putnam Valley, New York); Pritish Ranjan Parida (Fishkill, New York); Mark Delorman Schultz (Ossining, New York)
ABSTRACT	Techniques that facilitate two-phase liquid cooling electronics are provided. In one example, a server system comprises a two-phase cooling system and an air moving system. The two-phase cooling system reduces a first temperature of a first electronic component in the server system using a pump that circulates a coolant refrigerant through a two-phase refrigerant loop associated with the first electronic component, where first electronic component satisfies a first defined criterion. The air moving system reduces a second temperature of a second electronic component in the server system using one or more fans associated with the second electronic component, where the second electronic component satisfies a second defined criterion.
FILED	Thursday, December 14, 2017
APPL NO	15/841752
ART UNIT	2835 — Electrical Circuits and Systems
CURRENT CPC	Electric Digital Data Processing G06F 1/20 (20130101) G06F 1/206 (20130101) G06F 1/3206 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101) H01L 23/467 (20130101) H01L 23/473 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/208 (20130101) H05K 7/20136 (20130101) H05K 7/20145 (20130101) H05K 7/20209 (20130101) H05K 7/20309 (20130101) H05K 7/20318 (20130101) H05K 7/20327 (20130101) H05K 7/20381 (20130101) Original (OR) Class H05K 7/20509 (20130101) H05K 7/20727 (20130101) H05K 7/20809 (20130101) H05K 7/20836 (20130101)
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D0868819 — Display screen or portion thereof with graphical user interface

US D868819	Burnett et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Gregory M Burnett (Dayton, Ohio); Isaiah L Bragg (Xenia, Ohio); Noah W Bragg (Beavercreek, Ohio); Matthew R. Weber (Beavercreek, Ohio); Jared S Dewey (Tucson, Arizona)
ABSTRACT
FILED	Friday, February 08, 2019
APPL NO	29/679661
ART UNIT	2916 — Design
CURRENT CPC	Recording, communication, or information retrieval equipment D14/486
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Department of Health and Human Services (HHS)

10492674 — Grading corneal fluorescein staining

US 10492674	Dana et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Massachusetts Eye and Ear Infirmary (Boston, Massachusetts)
ASSIGNEE(S)	Massachusetts Eye and Ear Infirmary (Boston, Massachusetts)
INVENTOR(S)	Reza Dana (Newton, Massachusetts); Francisco L. Amparo Pulido (Cambridge, Massachusetts); Haobing Wang (Newton, Massachusetts)
ABSTRACT	The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
FILED	Monday, June 25, 2018
APPL NO	16/016898
ART UNIT	2872 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/14 (20130101) A61B 3/0025 (20130101) Original (OR) Class A61B 3/1025 (20130101) A61B 5/0071 (20130101) A61B 5/1032 (20130101) A61B 5/4848 (20130101)
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10492702 — Real-time cortical mapping

US 10492702	Chang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Edward Chang (San Francisco, California); Connie Cheung (San Jose, California)
ABSTRACT	Methods of cortical mapping in real-time are provided. Aspects of the methods include performing real-time processing of signals indicative of a subject's brain activity by applying one filter or more to the signals, wherein the processing is in the absence of averaging based on time. Systems for cortical mapping in real-time are also provided. The methods and systems are useful in research, diagnostic, and therapeutic applications.
FILED	Wednesday, January 30, 2013
APPL NO	14/375099
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/048 (20130101) A61B 5/0484 (20130101) A61B 5/742 (20130101) A61B 5/743 (20130101) A61B 5/04001 (20130101) A61B 5/04012 (20130101) Original (OR) Class A61B 5/4094 (20130101) A61B 5/4848 (20130101) A61B 2562/046 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101)
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10492710 — System and method for spectroscopic magnetic resonance fingerprinting

US 10492710	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Charlie Y. Wang (Cleveland, Ohio); Mark A. Griswold (Shaker Heights, Ohio); Xin Yu (Cleveland, Ohio)
ABSTRACT	The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (MRF). The method comprises performing a pulse sequence using a series of varied sequence blocks to a volume in a subject where the volume contains phosphate metabolites. A series of signal evolutions are acquired from the volume in the subject to form MRF data. The MRF data is then compared to simulated MRF signal to determine parameters associated with phosphate metabolites and the chemical exchange rates between these metabolites. These parameters and exchange rates can be used in diagnosing a metabolic disorder in a subject.
FILED	Monday, May 08, 2017
APPL NO	15/589295
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class A61B 5/4866 (20130101) A61B 5/14546 (20130101) A61B 2576/00 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/448 (20130101) G01R 33/465 (20130101) G01R 33/4625 (20130101)
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10492719 — Clinical assessment of fragile bone strength

US 10492719	Kopperdahl et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	O.N.Diagnostics, LLC (Berkeley, California)
ASSIGNEE(S)	O.N.Diagnostics, LLC (Berkeley, California)
INVENTOR(S)	David L. Kopperdahl (Berkeley, California); Paul Frederick Hoffmann (Oakland, California); David Choen Lee (Arcadia, California); Garry Thomas Hayeck (Lower Gwynedd, Pennsylvania); Tony M. Keaveny (Berkeley, California)
ABSTRACT	A system and method for the use of the results from a structural analysis of a patient's bone from a clinical scan, to be used clinically to manage patients in a widespread and consistent fashion.
FILED	Monday, December 18, 2017
APPL NO	15/845526
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4509 (20130101) Original (OR) Class A61B 5/7246 (20130101) A61B 6/032 (20130101) A61B 6/463 (20130101) A61B 6/482 (20130101) A61B 6/505 (20130101) A61B 6/5217 (20130101) A61B 8/0875 (20130101) A61B 8/5223 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 50/30 (20180101)
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10492723 — Predicting immunotherapy response in non-small cell lung cancer patients with quantitative vessel tortuosity

US 10492723	Madabhushi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Center for Research Resources (NCRR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Anant Madabhushi (Shaker Heights, Ohio); Mehdi Alilou (Cleveland, Ohio); Vamsidhar Velcheti (Pepper Pike, Ohio)
ABSTRACT	Embodiments classify a region of tissue demonstrating non-small cell lung cancer using quantified vessel tortuosity (QVT). One example apparatus includes annotation circuitry configured to segment a lung region from surrounding anatomy in the region of tissue represented in a radiological image and segment a nodule from the lung region by defining a nodule boundary; vascular segmentation circuitry configured to generate a three dimensional (3D) segmented vasculature by segmenting a vessel associated with the nodule, and to identify a center line of the 3D segmented vasculature; QVT feature extraction circuitry configured to extract a set of QVT features from the radiological image; and classification circuitry configured to compute a probability that the region of tissue will respond to immunotherapy and generate a classification that the region of tissue is a responder or a non-responder based, at least in part, on the probability.
FILED	Tuesday, January 30, 2018
APPL NO	15/883649
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/02007 (20130101) A61B 5/4839 (20130101) Original (OR) Class A61B 5/4842 (20130101) A61B 5/4848 (20130101) A61B 5/7264 (20130101) A61B 6/032 (20130101) A61B 6/504 (20130101) A61B 6/5217 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6262 (20130101) G06K 9/6268 (20130101) G06K 2009/00932 (20130101) G06K 2009/6213 (20130101) G06K 2209/051 (20130101) G06K 2209/053 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 7/0016 (20130101) G06T 2207/10081 (20130101) G06T 2207/20081 (20130101) G06T 2207/30064 (20130101) G06T 2207/30101 (20130101) G06T 2207/30172 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/50 (20180101)
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10492749 — Biopsy systems for breast computed tomography

US 10492749	Boone et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	John M. Boone (Folsom, California); Thomas R. Nelson (Del Mar, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	John M. Boone (Folsom, California); Thomas R. Nelson (Del Mar, California)
ABSTRACT	A device and methods for performing a simulated CT biopsy on a region of interest on a patient. The device comprises a gantry configured to mount an x-ray emitter and CT detector on opposing sides of the gantry, a motor rotatably coupled to the gantry such that the gantry rotates horizontally about the region of interest, and a high resolution x-ray detector positioned adjacent the CT detector in between the CT detector and the x-ray emitter.
FILED	Wednesday, May 03, 2006
APPL NO	11/913494
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/03 (20130101) A61B 6/12 (20130101) A61B 6/037 (20130101) A61B 6/405 (20130101) A61B 6/0435 (20130101) A61B 6/482 (20130101) Original (OR) Class A61B 6/502 (20130101) A61B 6/584 (20130101) A61B 6/4028 (20130101) A61B 6/4417 (20130101) A61B 6/4423 (20130101) A61B 6/5235 (20130101) A61B 8/0825 (20130101) A61B 8/4416 (20130101)
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10492822 — Concentric cutting devices for use in minimally invasive medical procedures

US 10492822	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Microfabrica Inc. (Van Nuys, California)
ASSIGNEE(S)	Microfabrica Inc. (Van Nuys, California)
INVENTOR(S)	Richard T. Chen (Woodland Hills, California); Ming-Ting Wu (Northridge, California); Arun Veeramani (Woodland Hills, California); Vacit Arat (La Canada Flintridge, California); Gregory P. Schmitz (Los Gatos, California)
ABSTRACT	Various embodiments of a tissue cutting device are described, such as a device with an elongate tube having a proximal end and a distal end and a central axis extending from the proximal end to the distal end; a first annular element at the distal end of the elongate tube, the first annular element having a flat portion at its distal end perpendicular to the central axis; and a second annular element at the distal end of the elongate tube and concentric with the first annular element, the second annular element having a flat portion at its distal end perpendicular to the central axis, at least one of the first or second annular elements rotatable about the central axis, the rotation causing the first annular element and the second annular element to pass each other to shear tissue.
FILED	Friday, February 14, 2014
APPL NO	14/181247
ART UNIT	3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 10/0266 (20130101) A61B 10/0283 (20130101) A61B 17/3203 (20130101) A61B 17/3205 (20130101) A61B 17/32002 (20130101) A61B 17/320758 (20130101) Original (OR) Class A61B 2017/00345 (20130101) A61B 2017/00526 (20130101) A61B 2017/320064 (20130101) A61B 2017/320775 (20130101)
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10492945 — Small molecule transport device with anti-condensation filler for drug delivery or waste removal

US 10492945	Tai et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Yu-Chong Tai (Pasadena, California); Nicholas Scianmarello (Pasadena, California); Colin A. Cook (Pasadena, California)
ABSTRACT	An implantable medical device is described. The implantable medical device includes an anti-condensation filler that is highly permeable to a predetermined class of small molecules, such as oxygen. The implantable medical device includes a small molecule discharge bag that is permeable to the small molecule, and a cannula that connects an interior of the small discharge bag to the anti-condensation filler. In operation, small molecules are collected and transported through the anti-condensation filler to the cannula for diffusion through the small molecule discharge bag. Even when this device is implanted in a high humidity and temperature gradient environment, the anti-condensation filler prevents condensation, such as water condensation.
FILED	Monday, May 21, 2018
APPL NO	15/985468
ART UNIT	3781 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0017 (20130101) Original (OR) Class A61F 2240/001 (20130101) A61F 2250/0068 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 39/10 (20130101) B29C 41/36 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2083/005 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7548 (20130101)
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10493038 — Formulation of acoustically activatable particles having low vaporization energy and methods for using same

US 10493038	Dayton et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The Arizona Board of Regents on behalf of The University of Arizona (Tucson, Arizona); The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona); The Regents of the University of Colorado (Denver, Colorado)
INVENTOR(S)	Paul Alexander Dayton (Carrboro, North Carolina); Paul Steven Sheeran (Durham, North Carolina); Terry Onichi Matsunaga (Tucson, Arizona); Mark A. Borden (Boulder, Colorado)
ABSTRACT	An acoustically activatable particle of material includes a first substance that includes a component that is a gas 25° C. and atmospheric pressure. A second substance, different from the first substance, encapsulates the first substance to create a droplet or emulsion that is stable at room temperature and atmospheric pressure. At least some of the first substance exists in a gaseous phase at the time of encapsulation of the first substance within the second substance to form a bubble. After formation of the bubble, the bubble is condensed into a liquid phase, which causes the bubble to transform into the droplet or emulsion having a core consisting of a liquid. The droplet or emulsion is an activatable phase change agent having a core consisting of a liquid at 25° C. and atmospheric pressure. The first substance has a boiling point below 25° C. at atmospheric pressure.
FILED	Thursday, January 25, 2018
APPL NO	15/880481
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) Original (OR) Class A61K 9/5123 (20130101) A61K 9/5192 (20130101) A61K 41/0028 (20130101) A61K 47/06 (20130101) A61K 48/00 (20130101) A61K 49/0002 (20130101) A61K 49/221 (20130101) A61K 49/223 (20130101) A61K 49/226 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/02 (20130101)
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10493061 — Compositions and methods comprising 2-(acylamino)imidazoles

US 10493061	Looper et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Curza Global, LLC (Provo, Utah); University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	Curza Global, LLC (Provo, Utah); University of Utag Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Ryan E. Looper (Salt Lake City, Utah); Rachel M. Vaden (Salt Lake City, Utah); Joseph B. Gibbons (Salt Lake City, Utah); Justin M. Salvant (Salt Lake City, Utah); Anne V. Edwards (Salt Lake City, Utah); Matthew S. Sigman (Salt Lake City, Utah); Bryan E. Welm (Edmond, Oklahoma)
ABSTRACT	The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.
FILED	Friday, September 16, 2016
APPL NO	15/268410
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) A61K 31/4168 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 31/5377 (20130101)
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10493072 — Lanthionine synthetase C-like 2-based therapeutics

US 10493072	Bassaganya-Riera et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Small Business Administration (SBA) Small Business Innovation Research (SBIR) Small Business Technology Transfer (STTR)
APPLICANT(S)	Landos Biopharma, Inc. (Blacksburg, Virginia)
ASSIGNEE(S)	LANDOS BIOPHARMA, INC. (Blacksburg, Virginia)
INVENTOR(S)	Josep Bassaganya-Riera (Blacksburg, Virginia); Adria Carbo Barrios (Blacksburg, Virginia); Richard Gandour (Blacksburg, Virginia); Julian D. Cooper (Blacksburg, Virginia); Raquel Hontecillas (Blacksburg, Virginia)
ABSTRACT	Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease.
FILED	Thursday, December 20, 2018
APPL NO	16/227940
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4439 (20130101) Acyclic or Carbocyclic Compounds C07C 65/40 (20130101) Heterocyclic Compounds C07D 213/69 (20130101) C07D 213/79 (20130101) C07D 307/60 (20130101) C07D 307/68 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101)
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10493087 — Sialylation-increasing therapies for diseases associated with oxidative stress

US 10493087	Huizing et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by National Institute of Health (Bethesda, Maryland)
INVENTOR(S)	Marjan Huizing (Santa Cruz, California); May C. Malicdan (Rockville, Maryland); Nuria Carrillo (Bethesda, Maryland)
ABSTRACT	Methods are disclosed for treating a subject with a vascular or cardiac disorder associated with oxidative stress. Methods are disclosed for treating a subject with GNE myopathy that has impaired cardiac function. These methods include administering to the subject a therapeutically effective amount of a acid, or one or more sialylated compounds, mannosamine, N-acetyl mannosamine or a derivative thereof. In other embodiments, methods are disclosed for detecting a disorder associated with oxidative stress.
FILED	Tuesday, February 23, 2016
APPL NO	15/553561
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/50 (20130101) A61K 9/0053 (20130101) A61K 9/127 (20130101) A61K 31/702 (20130101) A61K 31/7008 (20130101) Original (OR) Class A61K 31/7012 (20130101) A61K 31/7088 (20130101) A61K 45/06 (20130101) A61K 47/20 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101)
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10493131 — Materials and methods for modulating activity of bone marrow derived cells

US 10493131	Conrad et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	Kirk P. Conrad (Gainesville, Florida); Mark S. Segal (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Kirk P. Conrad (Gainesville, Florida); Mark S. Segal (Gainesville, Florida)
ABSTRACT	The subject invention provides methods for recruitment of bone marrow-derived cells, including bone marrow-derived endothelial cells (BMDEC), and increasing their function by administration of relaxin. The methods of the invention can be used in, for example, treating conditions amenable to treatment by recruitment of bone marrow-derived cells, such as BMDEC and bone marrow-derived angio-osteogcnic progenitor cell.
FILED	Thursday, August 30, 2012
APPL NO	14/240842
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/2221 (20130101) Original (OR) Class Peptides C07K 16/26 (20130101) C07K 16/2869 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1136 (20130101) C12N 15/1138 (20130101)
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10493141 — Viral RNA segments as immunomodulatory agents and vaccine components

US 10493141	Stapleton et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
ASSIGNEE(S)	THE UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
INVENTOR(S)	Jack T. Stapleton (Iowa City, Iowa); Nirjal Bhattarai (Coralville, Iowa); James McLinden (Coralville, Iowa); Jinhau Xiang (Iowa City, Iowa); Bev Davidson (Philadelphia, Pennsylvania)
ABSTRACT	The disclosure provides compositions and methods involving viral RNA segments for use in modulating immune responses, including inhibition inflammation related to pathogenic T-cell activation. In addition, modification of the viral sequences responsible for modulating immune response provides for improved vaccine formulations.
FILED	Wednesday, September 09, 2015
APPL NO	15/510315
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Peptides C07K 14/08 (20130101) C07K 14/473 (20130101) C07K 14/1833 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/04 (20130101) C12N 15/117 (20130101) C12N 2310/17 (20130101) C12N 2330/50 (20130101) C12N 2760/18711 (20130101) C12N 2770/24111 (20130101) C12N 2770/24211 (20130101)
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10493168 — Phosphorescent meso-unsubstituted metallo-porphyrin probe molecules for measuring oxygen and imaging methods

US 10493168	Vinogradov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Oxygen Enterprises, Ltd (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Oxygen Enterprises, Ltd (Philadelphia, Pennsylvania)
INVENTOR(S)	Sergei A. Vinogradov (Wynnewood, Pennsylvania); David F. Wilson (Philadelphia, Pennsylvania); Tatiana V. Esipova (Philadelphia, Pennsylvania)
ABSTRACT	Oxygen levels in biological tissue or systems can be measured by the phosphorescence quenching method using phosphorescent porphyrin probes, also referred to as a dendritic oxygen probes, with controllable quenching parameters and defined biodistributions. Provided are a “next generation” of oxygen sensors with substantially improved phosphorescence emission for better imaging capabilities, ease of use, increasing the quantum efficiency (phosphorescence intensity) and extending their range of applicability including constructing a class of oxygen sensors for making measurements in organic media. In addition, provided are methods for synthesizing new porphyrin constructs in which the porphyrin is made less flexible and more planar, changing with decrease internal quenching, and thereby increasing the phosphorescence emission used for oxygen sensing. Additional methods are provided for structurally modifying the dendrimer used to encapsulate the porphyrin phosphor to provide internal quenching of singlet oxygen molecules formed during oxygen measurements.
FILED	Monday, January 30, 2017
APPL NO	15/419614
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0015 (20130101) Original (OR) Class Heterocyclic Compounds C07D 487/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/84 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/207497 (20150115)
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10493169 — Use of charge-balanced imaging agents for determining renal function

US 10493169	Frangioni
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Beth Israel Deaconess Medical Center (Boston, Massachusetts); Georgia State University Research Foundation Inc. (Atlanta, Georgia)
ASSIGNEE(S)	Beth Israel Deaconess Medical Center (Boston, Massachusetts); Georgia State University Research Foundation Inc. (Atlanta, Georgia)
INVENTOR(S)	John V. Frangioni (Wayland, Massachusetts)
ABSTRACT	The present invention relates to a method for detecting renal disease and for assessing the efficacy of dialysis treatment using imaging agents having desirable in vivo properties.
FILED	Monday, June 26, 2017
APPL NO	15/633349
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 6/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) Original (OR) Class Heterocyclic Compounds C07D 209/02 (20130101) C07D 209/42 (20130101) C07D 255/02 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 23/0066 (20130101) C09B 23/086 (20130101) C09B 67/0025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 2800/347 (20130101)
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10493172 — Gas-filled structures and related compositions, methods and systems to image a target site

US 10493172	Lakshmanan et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Anupama Lakshmanan (Pasadena, California); Arash Farhadi (Pasadena, California); Suchita P. Nety (Sunnyvale, California); Raymond W. Bourdeau (Watertown, Massachusetts); Mikhail Shapiro (Los Angeles, California)
ABSTRACT	Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.
FILED	Friday, June 02, 2017
APPL NO	15/613104
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/481 (20130101) A61B 8/5238 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 49/0045 (20130101) A61K 49/0093 (20130101) A61K 49/221 (20130101) A61K 49/223 (20130101) Original (OR) Class Peptides C07K 14/195 (20130101) C07K 2319/00 (20130101)
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10493179 — Modified silk films containing glycerol

US 10493179	Lu et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Trustees of Tufts College (Medford, Massachusetts)
ASSIGNEE(S)	Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S)	Shenzhou Lu (Suzhou, China PRC); Xiaoqin Wang (Winchester, Massachusetts); Fiorenzo Omenetto (Lexington, Massachusetts); David L. Kaplan (Concord, Massachusetts)
ABSTRACT	The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50% (w/w) glycerol, and are prepared by entirely aqueous processes. The ductile silk film may be further treated by extracting the glycerol from and re-drying the silk film. Active agents may be embedded in or deposited on the glycerol modified silk film for a variety of medical applications. The films may be shaped into 3-dimensional structures, or placed on support surfaces as labels or coatings. The glycerol modified silk films of the present invention are useful in variety of applications such as tissue engineering, medical devices or implants, drug delivery, and edible pharmaceutical or food labels.
FILED	Tuesday, June 30, 2015
APPL NO	14/755215
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/3604 (20130101) Original (OR) Class A61L 27/3804 (20130101) A61L 2420/06 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/30 (20130101) B05D 3/107 (20130101) B05D 3/0254 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/18 (20130101) C08J 5/18 (20130101) C08J 2389/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/053 (20130101) C08K 5/053 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/02 (20130101)
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10493263 — Onychomycosis treatment system and method

US 10493263	Roe et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF)
APPLICANT(S)	DEVICEFARM, INC. (Newark, California)
ASSIGNEE(S)
INVENTOR(S)	Jeffrey N Roe (Pleasanton, California); Timothy C Grammer (Pleasant Hill, California); Eric Tridas (St. Petersburg, Florida); Raul Ignacio Barrera-Barraza (Fremont, California); Joel Sterling Douglas (Bonita Springs, Florida)
ABSTRACT	A system and method includes delivery of a redox gas solution to treat onychomycosis, wherein the redox gas solution comprises a reactive species dissolved in a perfluorocarbon liquid, and wherein the perfluorocarbon liquid is dispensed onto a gas-permeable membrane and the perfluorocarbon liquid comprises of an anti-inflammatory in a perfluorocarbon liquid and wherein the reactive species may include, alone or in combination, one or more of reactive oxygen, reactive nitrogen, reactive chlorine, or reactive bromine species, and the perfluorocarbon liquid may include perfluorodecalin.
FILED	Thursday, August 10, 2017
APPL NO	15/674120
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/18 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/068 (20130101) A61F 13/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/02 (20130101) A61K 33/04 (20130101) A61K 33/20 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/44 (20130101) A61N 1/0428 (20130101) Original (OR) Class
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10493379 — Caged bags of porous materials

US 10493379	Giese et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	Roger W. Giese (Hanover, Massachusetts); Zhenwei Shi (West Roxbury, Massachusetts); Michael R. MacNeil (Quincy, Massachusetts); Poguang Wang (Westborough, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	Roger W. Giese (Hanover, Massachusetts); Gang Shao (West Roxbury, Massachusetts); Michael R. MacNeil (Quincy, Massachusetts); Poguang Wang (Westborough, Massachusetts)
ABSTRACT	Systems and methods employing beds of bagged and caged absorbent and adsorbent materials are disclosed. These inventions are useful in the area of solid phase extraction.
FILED	Wednesday, July 31, 2013
APPL NO	13/955512
ART UNIT	1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 15/12 (20130101) B01D 15/20 (20130101) B01D 15/1892 (20130101) Original (OR) Class Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/02 (20130101) B01J 8/008 (20130101) B01J 19/2485 (20130101) B01J 20/00 (20130101) B01J 20/20 (20130101) B01J 20/103 (20130101) B01J 20/261 (20130101) B01J 20/2805 (20130101) B01J 2208/028 (20130101) B01J 2208/00876 (20130101) B01J 2208/00884 (20130101) B01J 2219/2449 (20130101) B01J 2219/2498 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) G01N 30/14 (20130101) G01N 2030/009 (20130101)
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10494328 — Amination and hydroxylation of arylmetal compounds

US 10494328	Gao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) Non-Profit Organization (NPO) Robert A. Welch Foundation National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	WILLIAM MARSH RICE UNIVERSITY (Houston, Texas)
ASSIGNEE(S)	William Marsh Rice University (Houston, Texas)
INVENTOR(S)	Hongyin Gao (Houston, Texas); Zhe Zhou (Houston, Texas); Laszlo Kurti (Bellaire, Texas)
ABSTRACT	In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.
FILED	Tuesday, July 25, 2017
APPL NO	15/659320
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	General Methods of Organic Chemistry; Apparatus Therefor C07B 41/02 (20130101) C07B 43/04 (20130101) Acyclic or Carbocyclic Compounds C07C 37/01 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/64 (20130101) C07C 37/64 (20130101) C07C 39/12 (20130101) C07C 39/14 (20130101) C07C 39/15 (20130101) C07C 39/20 (20130101) C07C 39/205 (20130101) C07C 39/235 (20130101) C07C 41/26 (20130101) C07C 41/26 (20130101) C07C 43/23 (20130101) C07C 209/66 (20130101) Original (OR) Class C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 211/44 (20130101) C07C 211/47 (20130101) C07C 211/51 (20130101) C07C 211/58 (20130101) C07C 211/59 (20130101) C07C 211/61 (20130101) C07C 213/02 (20130101) C07C 213/02 (20130101) C07C 213/02 (20130101) C07C 213/02 (20130101) C07C 217/80 (20130101) C07C 217/94 (20130101) C07C 219/34 (20130101) C07C 227/06 (20130101) C07C 227/06 (20130101) C07C 227/06 (20130101) C07C 229/56 (20130101) C07C 229/60 (20130101) C07C 303/30 (20130101) C07C 303/30 (20130101) C07C 309/30 (20130101) C07C 319/20 (20130101) C07C 319/20 (20130101) C07C 323/36 (20130101) C07C 2601/02 (20170501) C07C 2601/04 (20170501) C07C 2601/14 (20170501) C07C 2603/18 (20170501) C07C 2603/26 (20170501) Heterocyclic Compounds C07D 209/04 (20130101) C07D 209/88 (20130101) C07D 213/04 (20130101) C07D 213/73 (20130101) C07D 215/38 (20130101) C07D 277/82 (20130101) C07D 295/096 (20130101) C07D 295/135 (20130101) C07D 307/79 (20130101) C07D 307/91 (20130101) C07D 309/12 (20130101) C07D 311/58 (20130101) C07D 317/20 (20130101) C07D 317/28 (20130101) C07D 317/46 (20130101) C07D 317/64 (20130101) C07D 317/66 (20130101) C07D 333/16 (20130101) C07D 333/20 (20130101) C07D 333/36 (20130101) Steroids C07J 41/0011 (20130101)
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10494332 — Protein tyrosine phosphatases or SHP2 inhibitors and uses thereof

US 10494332	Zhang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Indiana University Research and Technology Corporation (Indianapolis, Indiana)
ASSIGNEE(S)	Indiana University Research and Technology Corporation (Indianapolis, Indiana)
INVENTOR(S)	Zhong-Yin Zhang (West Lafayette, Indiana); Rongjun He (Indianapolis, Indiana)
ABSTRACT	Small molecule compounds derived from α-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (PTPs), such as mPTPA, mPTPB, LMWPTP, and Laforin. Use of these compounds as pharmaceutical agents for treating diseases associated with abnormal protein tyrosine phosphatase activity is also provided.
FILED	Wednesday, June 01, 2016
APPL NO	15/577417
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 25/28 (20180101) A61P 31/06 (20180101) A61P 35/00 (20180101) A61P 35/02 (20180101) Acyclic or Carbocyclic Compounds C07C 309/17 (20130101) C07C 309/18 (20130101) C07C 309/24 (20130101) Original (OR) Class Heterocyclic Compounds C07D 211/16 (20130101) C07D 211/18 (20130101) C07D 215/08 (20130101) C07D 215/38 (20130101) C07D 231/40 (20130101) C07D 233/61 (20130101) C07D 233/64 (20130101) C07D 235/10 (20130101) C07D 235/14 (20130101) C07D 277/46 (20130101) C07D 277/82 (20130101) C07D 285/135 (20130101) C07D 295/135 (20130101) C07D 307/68 (20130101) C07D 333/20 (20130101)
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10494337 — (20S)-1-α,25-dihydroxy-24,24-difluoro-19-nor-vitamin D₃analogs and their pharmaceutical uses

US 10494337	DeLuca et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	Hector F. DeLuca (Deerfield, Wisconsin); Agnieszka Flores (Sun Prairie, Wisconsin); Lori A. Plum (Arena, Wisconsin); Hazel Holden (Fitchburg, Wisconsin); James Thoden (Madison, Wisconsin)
ABSTRACT	Disclosed are 1α,25-dihydroxy-24,24-difluoro-2-methylene-19-nor-vitamin D analogs and their pharmaceutical uses. These new vitamin D analogs are 19-nor-vitamin D analogs having two fluorine atom substitutions at the 24 position (C-24) in the side chain and optionally having a 2-methylene substituent.
FILED	Thursday, May 26, 2016
APPL NO	15/165884
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 401/00 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/1804 (20130101)
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10494365 — Small molecule inhibitor of 3-phosphoglycerate dehydrogenase and uses thereof

US 10494365	Cantley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Scripps Research Institute (La Jolla, California); Cornell University (Ithaca, New York)
ASSIGNEE(S)	Cornell University (Ithica, New York); The Scripps Research Institute (La Jolla, California)
INVENTOR(S)	Lewis C. Cantley (Cambridge, Massachusetts); Edouard Mullarky (New York, New York); Costas Lyssiotis (Ann Arbor, Michigan); Luke L. Lairson (San Diego, California); Natasha Lucki (San Diego, California)
ABSTRACT	Embodiments of the present invention are directed to small molecule inhibitors of PHGDH. Other embodiments of the present invention relate to methods of treating cancers using the small molecule inhibitors of PHGDH disclosed herein. Still other embodiments of the present invention relate to methods for using the small molecule inhibitors of PHGDH to study serine metabolism.
FILED	Friday, December 30, 2016
APPL NO	16/067141
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 409/12 (20130101) Original (OR) Class
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10494385 — Near-IR glucose sensors

US 10494385	Gamsey et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Profusa, Inc. (South San Francisco, California)
ASSIGNEE(S)	Profusa, Inc. (South San Francisco, California)
INVENTOR(S)	Soya Gamsey (San Francisco, California); Viachaslau Bernat (Burlingame, California); Alex Kutyavin (Lake Stevens, Washington); Jacob William Clary (Moss Beach, California); Sulolit Pradhan (Foster City, California)
ABSTRACT	The present disclosure provides polymerizable luminescent dyes useful for incorporation into polymers. The dyes and the polymers can be used in sensing and imaging applications, for example, to provide accurate and optionally long term measurements of glucose in vivo. The present disclosure also provides sensors including the polymers described herein. The sensors can be implanted into a tissue of a subject and used for long-term or short-term continuous and semi-continuous collection of data of various biochemical analytes, optionally without the use of implantable hardware of any type and/or enzymatic and electrochemical detection methods.
FILED	Wednesday, July 18, 2018
APPL NO	16/038657
ART UNIT	1622 — Organic Chemistry
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/1459 (20130101) A61B 5/14532 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 1/002 (20130101) C09B 11/24 (20130101) C09B 11/28 (20130101) C09B 23/04 (20130101) C09B 23/0008 (20130101) C09B 23/0016 (20130101) C09B 23/0025 (20130101) C09B 23/0066 (20130101) C09B 23/083 (20130101) C09B 23/086 (20130101) C09B 57/00 (20130101) C09B 57/02 (20130101) C09B 69/008 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/104 (20130101) C09K 2211/1055 (20130101) C09K 2211/1096 (20130101)
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10494389 — STAT3 dimerization inhibitors

US 10494389	Sebti et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida)
ASSIGNEE(S)	H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida)
INVENTOR(S)	Said M. Sebti (Tampa, Florida); Nicholas James Lawrence (Tampa, Florida); Harshani Rithma Lawrence (Tampa, Florida)
ABSTRACT	The subject matter disclosed herein relates to compositions and methods of making and using the compositions. In a further aspect, the subject matter disclosed herein relates to inhibitors of STAT3 dimerization. Methods of making these compositions as well as compositions comprising these compositions are also disclosed. Also disclosed are methods of treating or preventing certain cancers by administering to an individual in need thereof and effective amount of the compounds disclosed herein. Still further, disclosed herein are methods of inhibiting STAT3 by contacting a cell with a compound or composition as disclosed herein.
FILED	Monday, November 20, 2017
APPL NO	15/818071
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) Acyclic or Carbocyclic Compounds C07C 233/76 (20130101) C07C 311/18 (20130101) Heterocyclic Compounds C07D 211/10 (20130101) C07D 213/16 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3834 (20130101) Original (OR) Class C07F 9/3882 (20130101) C07F 9/4021 (20130101) C07F 9/4056 (20130101)
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10494401 — LLP2A-bisphosphonate conjugates for osteoporosis treatment

US 10494401	Lam et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Kit S. Lam (Davis, California); Ruiwu Liu (Sacramento, California); Wei Yao (El Dorado Hills, California); Nancy Lane (Hillsborough, California)
ABSTRACT	The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the α₄β₁integrin on mesenchymal stem cells and for the surface of bone.
FILED	Wednesday, December 21, 2016
APPL NO	15/387380
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/66 (20130101) A61K 31/661 (20130101) A61K 31/663 (20130101) A61K 35/28 (20130101) A61K 38/00 (20130101) A61K 38/06 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 47/64 (20170801) A61K 47/548 (20170801) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/02 (20130101) Peptides C07K 5/101 (20130101) C07K 5/0817 (20130101) C07K 5/0821 (20130101) Original (OR) Class C07K 5/1016 (20130101) C07K 5/1019 (20130101) C07K 7/06 (20130101)
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10494405 — Methods and compositions for the treatment of arthritis

US 10494405	Holoshitz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Joseph Holoshitz (Ann Arbor, Michigan); Katarzyna Sobczyk-Kojiro (Ann Arbor, Michigan); Song Ling (Ypsilanti, Michigan); Henry I. Mosberg (Ann Arbor, Michigan)
ABSTRACT	The present disclosure relates to methods and compositions for treating disease related to disorders of bone remodeling. In particular, the present disclosure relates to cyclic peptide compositions and methods for treating rheumatoid arthritis.
FILED	Friday, May 13, 2016
APPL NO	15/573962
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 38/12 (20130101) A61K 38/14 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Peptides C07K 7/06 (20130101) C07K 7/56 (20130101) C07K 9/001 (20130101) Original (OR) Class
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10494417 — Peptide inhibitors of BCR-ABL oligomerization

US 10494417	Lim et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
INVENTOR(S)	Carol Lim (Salt Lake City, Utah); Benjamin J. Bruno (Salt Lake City, Utah); Geoffrey D. Miller (Salt Lake City, Utah); Andrew S. Dixon (Salt Lake City, Utah)
ABSTRACT	In one aspect, the invention relates to peptides comprising the Bcr-Abl coiled-coil oligomerization domain and an alpha helix stabilizing moiety, mutant forms thereof, truncated forms thereof, derivatives thereof, and related peptides, which are useful as inhibitors of the Bcr-Abl chimeric protein; pharmaceutical compositions comprising the compounds; and methods of treating hyperproliferative disorders associated with Bcr-Abl using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED	Wednesday, March 25, 2015
APPL NO	15/128642
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/5025 (20130101) A61K 38/00 (20130101) A61K 38/17 (20130101) Peptides C07K 14/82 (20130101) Original (OR) Class
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10494434 — Tagged chimeric effector molecules and receptors thereof

US 10494434	Riddell et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Fred Hutchinson Cancer Research Center (Seattle, Washington)
ASSIGNEE(S)	FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington)
INVENTOR(S)	Stanley R. Riddell (Sammamish, Washington); Lingfeng Liu (Seattle, Washington)
ABSTRACT	The present disclosure relates to tagged chimeric effector molecules and receptor molecules thereof for genetically engineering a host cell, wherein the recombinant host cell can be identified, isolated, sorted, induced to proliferate, tracked or eliminated using the tag. An exemplary receptor molecule is a chimeric antigen receptor (CAR) having an extracellular domain comprising a binding domain for a target, a hinge region, and a tag cassette, a hydrophobic portion as a transmembrane domain and an intracellular part with an effector domain. An exemplary target is CD19. An exemplary tag is a Strep Tag®. T cells recombinantly modified for expression of such molecules may be used in adoptive immunotherapy.
FILED	Monday, December 22, 2014
APPL NO	15/106657
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/545 (20130101) A61K 38/1774 (20130101) A61K 38/2013 (20130101) A61K 38/2013 (20130101) A61K 38/2086 (20130101) A61K 38/2086 (20130101) A61K 2035/124 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2878 (20130101) C07K 2317/64 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/20 (20130101) C07K 2319/22 (20130101) C07K 2319/33 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 5/0638 (20130101) C12N 2501/2302 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101)
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10494435 — Human monoclonal antibodies specific for CD22

US 10494435	Dimitrov et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The Government of the U.S.A. as represented by the Secretary of the Dept. of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The Government of the United States America as represented by the Secretary of the Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Dimiter S. Dimitrov (Frederick, Maryland); Xiaodong Xiao (Frederick, Maryland); Ira H. Pastan (Potomac, Maryland)
ABSTRACT	Disclosed herein are isolated human monoclonal antibodies that specifically bind human CD22 with a dissociation constant (K_d) of 25 nM or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. The antibodies can be used to detect human CD22 in a sample. In some cases, CD22 is soluble CD22. Methods of diagnosing a B-cell malignancy, or confirming a B-cell malignancy diagnosis, are disclosed herein that utilize these antibodies. Methods of treating a subject with a B-cell malignancy are also disclosed.
FILED	Friday, February 03, 2017
APPL NO	15/424238
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) A61K 38/164 (20130101) A61K 39/00 (20130101) A61K 39/39558 (20130101) A61K 47/6829 (20170801) A61K 47/6849 (20170801) A61K 47/6867 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/28 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2896 (20130101) C07K 2317/21 (20130101) C07K 2317/51 (20130101) C07K 2317/55 (20130101) C07K 2317/92 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) Enzymes C12Y 204/02036 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) G01N 2333/70503 (20130101)
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10494470 — Post polymerization cure shape memory polymers

US 10494470	Wilson et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Thomas S. Wilson (San Leandro, California); Michael Keith Hearon (Boston, Massachusetts); Jane P. Bearinger (Berwyn, Pennsylvania)
ABSTRACT	This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape.
FILED	Wednesday, December 21, 2016
APPL NO	15/387256
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 48/00 (20190201) B29C 48/03 (20190201) B29C 51/00 (20130101) B29C 51/002 (20130101) B29C 61/06 (20130101) B29C 67/20 (20130101) B29C 71/02 (20130101) B29C 71/04 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/00 (20130101) B29K 2105/04 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/83 (20130101) C08G 18/673 (20130101) C08G 18/675 (20130101) C08G 18/722 (20130101) C08G 18/758 (20130101) C08G 18/3206 (20130101) Original (OR) Class C08G 63/52 (20130101) C08G 2101/00 (20130101) C08G 2280/00 (20130101)
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10494479 — Polymeric nanogels with degradable backbones and from GRAS components, and compositions and methods thereof

US 10494479	Thayumanavan et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Sankaran Thayumanavan (Amherst, Massachusetts); Rajasekhar R. Ramireddy (Amherst, Massachusetts)
ABSTRACT	The invention generally relates to novel polymers and polymeric nanogels having biodegradable polymeric backbones, and compositions and methods of preparation and use thereof, for example, as guest-host polymer nano-assemblies and nano-delivery vehicles, which offer utilities in diverse fields including drug delivery, diagnostics and specialty materials.
FILED	Saturday, November 03, 2018
APPL NO	16/179932
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/10 (20130101) C08G 69/26 (20130101) C08G 69/48 (20130101) Original (OR) Class
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10494602 — Functional astrocytes and cortical neurons from induced pluripotent stem cells and methods of use thereof

US 10494602	Sloan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Steven Sloan (Palo Alto, California); Anca M. Pasca (Palo Alto, California); Ben A. Barres (Palo Alto, California); Sergiu P. Pasca (Palo Alto, California)
ABSTRACT	Human pluripotent stem cells are differentiated in vitro into human cortical spheroids (hCS), which contain astrocytes, as well as cortical progenitors and neurons for use in analysis, screening programs, and the like.
FILED	Wednesday, May 18, 2016
APPL NO	15/158408
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) Original (OR) Class C12N 2501/11 (20130101) C12N 2501/13 (20130101) C12N 2501/115 (20130101) C12N 2506/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101)
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10494610 — Three dimensional matrix for cancer stem cells

US 10494610	Jabbari
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina)
ASSIGNEE(S)	University of South Carolina (Columbia, South Carolina)
INVENTOR(S)	Esmaiel Jabbari (Columbia, South Carolina)
ABSTRACT	Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.
FILED	Friday, November 30, 2018
APPL NO	16/205489
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0695 (20130101) Original (OR) Class C12N 2533/30 (20130101) C12N 2537/10 (20130101)
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10494612 — Adeno-associated virus virions with variant capsid and methods of use thereof

US 10494612	Schaffer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	David V. Schaffer (Danville, California); Ryan R. Klimczak (San Francisco, California); James T. Koerber (San Francisco, California); John G. Flannery (Berkeley, California)
ABSTRACT	The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
FILED	Tuesday, August 23, 2016
APPL NO	15/244897
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2217/05 (20130101) A01K 2227/105 (20130101) A01K 2267/0356 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 35/76 (20130101) A61K 38/00 (20130101) A61K 38/179 (20130101) A61K 38/185 (20130101) A61K 38/1808 (20130101) A61K 38/1825 (20130101) A61K 48/0008 (20130101) A61K 48/0075 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) C12N 2750/14145 (20130101) C12N 2810/855 (20130101)
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10494613 — Generation of infectious influenza viruses from virus-like particles

US 10494613	Kawaoka et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS)
APPLICANT(S)	Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin)
INVENTOR(S)	Yoshihiro Kawaoka (Middleton, Wisconsin); Gabriele Neumann (Madison, Wisconsin)
ABSTRACT	Compositions and methods to prepare influenza virus-like particles (VLPs) are provided.
FILED	Thursday, August 25, 2016
APPL NO	15/247006
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2760/16123 (20130101) C12N 2760/16151 (20130101) C12N 2760/16223 (20130101) C12N 2760/16251 (20130101)
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10494619 — High isomerohydrolase activity mutants of human RPE65

US 10494619	Ma et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S)	The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
INVENTOR(S)	Jian-Xing Ma (Edmond, Oklahoma); Yusuke Takahashi (Oklahoma City, Oklahoma); Gennadiy Moiseyev (Edmond, Oklahoma)
ABSTRACT	Mutant mammalian RPE65 proteins and portions thereof, and nucleic acids encoding the mutants, for use in treating a condition related to retinal degeneration in a subject, the mutant mammalian RPE65 proteins or portions thereof having isomerohydrolase activity. A gene therapy method of treating a condition related to retinal degeneration in a mammalian subject in need of such treatment, comprising administering to the subject a therapeutically-effective amount of a vector comprising a nucleic acid encoding a mutant mammalian RPE65 protein or a portion thereof. A method of treating a condition related to retinal degeneration in a subject in need of such treatment, comprising administering to the subject a therapeutically-effective amount of at least one of a mutant mammalian RPE65 protein or a portion thereof.
FILED	Monday, July 27, 2015
APPL NO	15/500837
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/18 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2710/10343 (20130101) Enzymes C12Y 301/01064 (20130101)
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10494621 — Crispr enzyme mutations reducing off-target effects

US 10494621	Zhang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Feng Zhang (Cambridge, Massachusetts); Linyi Gao (Cambridge, Massachusetts); Bernd Zetsche (Gloucester, Massachusetts); Ian Slaymaker (Cambridge, Massachusetts)
ABSTRACT	Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.
FILED	Thursday, October 11, 2018
APPL NO	16/158295
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/902 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 301/00 (20130101)
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10494645 — Effective delivery of large genes by dual AAV vectors

US 10494645	Auricchio et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Fondazione Telethon (Rome, Italy)
ASSIGNEE(S)	FONDAZIONE TELETHON (Rome, Italy)
INVENTOR(S)	Alberto Auricchio (Naples, Italy); Pasqualina Colella (Naples, Italy); Ivana Trapani (Naples, Italy)
ABSTRACT	The present invention relates to constructs, vectors, relative host cells and pharmaceutical compositions which allow an effective gene therapy, in particular of genes larger than 5 Kb.
FILED	Friday, April 18, 2014
APPL NO	14/785229
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2800/40 (20130101) C12N 2840/20 (20130101) C12N 2840/44 (20130101) C12N 2840/445 (20130101)
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10494662 — Method for generating a three-dimensional nucleic acid containing matrix

US 10494662	Church et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	George M. Church (Brookline, Massachusetts); Je-Hyuk Lee (Allston, Massachusetts); Richard C. Terry (Carlisle, Massachusetts); Evan R. Daugharthy (Cambridge, Massachusetts)
ABSTRACT	Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
FILED	Wednesday, October 18, 2017
APPL NO	15/786921
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 2565/501 (20130101)
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10494664 — Methods and compositions for detecting a target RNA

US 10494664	Doudna et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Jennifer A. Doudna (Berkeley, California); Mitchell Ray O'Connell (Oakland, California); Alexandra East-Seletsky (San Francisco, California); Spencer Charles Knight (Berkeley, California); James Harrison Doudna Cate (Berkeley, California)
ABSTRACT	The present disclosure provides methods for detecting a single-stranded target RNA. The present disclosure provides methods of cleaving a precursor C2c2 guide RNA array into two or more C2c2 guide RNAs. The present disclosure provides a kit for detecting a target RNA in a sample.
FILED	Tuesday, March 13, 2018
APPL NO	15/920222
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) Original (OR) Class C12Q 1/6823 (20130101) C12Q 2521/327 (20130101) Technologies for Adaptation to Climate Change Y02A 50/53 (20180101) Y02A 50/54 (20180101) Y02A 50/57 (20180101) Y02A 50/58 (20180101) Y02A 50/60 (20180101)
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10494669 — Non-invasive diagnosis of graft rejection in organ transplant patients

US 10494669	Quake et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) NIH Office of the Director (NIHOD)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Stephen R. Quake (Stanford, California); Thomas M. Snyder (Palo Alto, California); Hannah Valantine (Stanford, California)
ABSTRACT	The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
FILED	Thursday, August 23, 2018
APPL NO	16/110646
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6837 (20130101) C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201)
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10494672 — Systems and methods for genetic and biological analysis

US 10494672	Esfandyarpour et al.
FUNDED BY	Department of Health and Human Services (HHS) Department of the Treasury (TREASURY) Internal Revenue Service (IRS)
APPLICANT(S)	GenapSys, Inc. (Redwood City, California)
ASSIGNEE(S)	GENAPSYS, INC. (Redwood City, California)
INVENTOR(S)	Hesaam Esfandyarpour (Redwood City, California); Kosar Baghbani Parizi (Redwood City, California); Mark F. Oldham (Emerald Hills, California); Eric S. Nordman (Palo Alto, California); Richard T. Reel (Hayward, California); Susanne Baumhueter (Redwood City, California); Cheryl Heiner (La Honda, California); Frank Lee (Irvine, California)
ABSTRACT	The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.
FILED	Friday, February 22, 2019
APPL NO	16/283544
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 1/6874 (20130101) C12Q 2527/119 (20130101) C12Q 2527/119 (20130101) C12Q 2549/126 (20130101) C12Q 2563/116 (20130101) C12Q 2563/116 (20130101) C12Q 2565/607 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) G01N 33/5438 (20130101) G01N 33/54313 (20130101)
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10495631 — In vitro model of macrosteatotic (fatty) liver

US 10495631	Yarmush et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S)	Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
INVENTOR(S)	Martin L. Yarmush (Newton, Massachusetts); Nir I. Nativ (West Orange, New Jersey); Francois Berthiaume (Metuchen, New Jersey); Gabriel A. Yarmush (Linden, New Jersey); Tim Maguire (Piscataway, New Jersey); Rene S. Schloss (East Brunswick, New Jersey)
ABSTRACT	The present invention relates to a system and methods for identifying a compound for de-fatting and functional recovery of macrosteatotic hepatocytes.
FILED	Monday, July 17, 2017
APPL NO	15/651348
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) C12N 2533/54 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5067 (20130101) Original (OR) Class
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10495639 — OmpA in vaccine compositions and as diagnostic targets

US 10495639	Carlyon
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Virginia Commonwealth University (Richmond, Virginia)
ASSIGNEE(S)	VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia)
INVENTOR(S)	Jason A. Carlyon (Richmond, Virginia)
ABSTRACT	Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. OmpA proteins or peptide fragments may be used in combination with other Anaplasmatacaea surface proteins to elicit an immune response. Furthermore, antibodies to OmpA proteins can be used in diagnostic methods to determine whether an individual has contracted an Anaplasmatacaea infection.
FILED	Wednesday, March 07, 2018
APPL NO	15/914515
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/40 (20130101) A61K 39/0233 (20130101) A61K 2039/70 (20130101) A61K 2039/552 (20130101) A61K 2039/6031 (20130101) A61K 2039/6081 (20130101) A61K 2039/55566 (20130101) Peptides C07K 16/1203 (20130101) C07K 16/1246 (20130101) C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2319/23 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) Original (OR) Class G01N 33/56983 (20130101) G01N 2333/29 (20130101) G01N 2333/195 (20130101) G01N 2469/10 (20130101) G01N 2469/20 (20130101) G01N 2800/42 (20130101)
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10495640 — Exosome-mediated diagnosis of hepatitis virus infections and diseases

US 10495640	Newman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	MOREHOUSE SCHOOL OF MEDICINE (Atlanta, Georgia)
ASSIGNEE(S)	MOREHOUSE SCHOOL OF MEDICINE (Atlanta, Georgia)
INVENTOR(S)	Gale W. Newman (Duluth, Georgia); Sam Anyanwu (Atlanta, Georgia)
ABSTRACT	A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for-monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject.
FILED	Tuesday, December 13, 2016
APPL NO	15/377054
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/703 (20130101) C12Q 1/706 (20130101) C12Q 1/707 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 33/493 (20130101) G01N 33/576 (20130101) G01N 33/6893 (20130101) G01N 33/56983 (20130101) G01N 33/56988 (20130101) Original (OR) Class G01N 2333/02 (20130101) G01N 2333/10 (20130101) G01N 2333/161 (20130101) G01N 2333/162 (20130101) G01N 2333/163 (20130101) G01N 2333/186 (20130101) G01N 2800/52 (20130101) G01N 2800/56 (20130101) G01N 2800/347 (20130101) Technologies for Adaptation to Climate Change Y02A 50/54 (20180101)
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10495651 — Methods and kits for measuring von Willebrand factor

US 10495651	Montgomery
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Versiti Blood Research Institute Foundation, Inc. (Milwaukee, Wisconsin); The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin)
ASSIGNEE(S)	Versiti Blood Research Institute Foundation, Inc. (Milwaukee, Wisconsin); The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin)
INVENTOR(S)	Robert Montgomery (Cedarburg, Wisconsin)
ABSTRACT	Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having a combination of G233V, D235Y and M239V mutations and an agent to detect a complex between the recombinant glycoprotein Ibα and von Willebrand factor.
FILED	Monday, May 15, 2017
APPL NO	15/595130
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/745 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) Original (OR) Class G01N 33/554 (20130101) G01N 33/5008 (20130101) G01N 2333/47 (20130101) G01N 2333/705 (20130101) G01N 2333/755 (20130101) G01N 2800/224 (20130101)
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10495717 — System and method for dual-kernel image reconstruction

US 10495717	Hoge et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	William S. Hoge (Watertown, Massachusetts); Jonathan R. Polimeni (Cambridge, Massachusetts)
ABSTRACT	A method and imaging system is provided that can control a magnetic gradient system and an RF system of an MRI system according to a calibration pulse sequence to acquire positive readout gradient (RO+) data and negative readout gradient (RO−) data. The RO+ data and the RQ− data are assembled to form complete image data sets for the RO+ data and the RQ™ data and the RO+ data and the RO− data are combined to generate the calibration data that is ghost-corrected, substantially free of ghost artifacts, or having reduced ghost artifacts compared to traditionally-acquired calibration data. Reconstruction coefficients are derived from the calibration data. The magnetic gradient system and the RF system are controlled according to an imaging pulse sequence to acquire image data and the image data is reconstructed into an image of the subject using the reconstruction coefficients.
FILED	Wednesday, August 19, 2015
APPL NO	15/505389
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/58 (20130101) G01R 33/5611 (20130101) G01R 33/5616 (20130101) G01R 33/56554 (20130101) Original (OR) Class Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/14 (20130101)
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10497117 — Automated percentage of breast density measurements for full field digital mammography

US 10497117	Heine et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (Rochester, Minnesota)
ASSIGNEE(S)	H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida); Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
INVENTOR(S)	John J. Heine (New Port Richey, Florida); Thomas A. Sellers (Tampa, Florida); Celine M. Vachon (Rochester, Minnesota); Erin E. Fowler (Tampa, Florida)
ABSTRACT	An automated percentage of breast density measure (PDa) that analyzes signal dependent noise (SDN) based on a wavelet expansion using full field digital mammography (FFDM). A matched case-control dataset is used with images acquired from a specific direct x-ray capture FFDM system. PDa is applied to the raw and clinical display representation images. Transforming (pixel mapping) of the raw image to another representation (raw-transformed) is performed using differential evolution optimization and investigated the influence of lowering the native spatial resolution of the image by a one-half. When controlling for body mass index, the quartile specific ORs for the associations of PDa with breast cancer varied with representation and resolution. PDa is a valid automated breast density measurement for a specific FFDM technology and compares well against PD (operator-assisted or the standard) when applied to either the raw-transformed or clinical display images from this FFDM technology.
FILED	Thursday, May 24, 2018
APPL NO	15/988143
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/502 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0051 (20130101) G06K 9/527 (20130101) G06K 9/623 (20130101) G06K 2209/05 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/41 (20170101) G06T 2207/10116 (20130101) G06T 2207/20076 (20130101) G06T 2207/30068 (20130101)
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10497741 — Apparatus and methods for optical emission detection

US 10497741	Wong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Wai-hoi Wong (Houston, Texas); Hongdi Li (Pearland, Texas); Rocio Alicia Ramirez-Jaramillo (Aguada, Puerto Rico); Yuxuan Zhang (Pearland, Texas); Hossain Baghaei (Sugar Land, Texas)
ABSTRACT	Apparatus and methods for optical emission detection comprising scintillating proximal sensors.
FILED	Wednesday, January 04, 2017
APPL NO	16/068168
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Nuclear or X-radiation G01T 1/20 (20130101) G01T 1/29 (20130101) G01T 1/164 (20130101) G01T 1/202 (20130101) G01T 1/1642 (20130101) G01T 1/2002 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14663 (20130101) Original (OR) Class H01L 31/09 (20130101)
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10498569 — Systems and methods for backscatter communication

US 10498569	Ganesan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Deepak Ganesan (Amherst, Massachusetts); Pengyu Zhang (Palo Alto, California)
ABSTRACT	Systems and methods for wireless communication are provided. The systems and methods employ a backscatter tag that is configured to shift an incident carrier signal received by the tag to a different frequency band and then transmitting the frequency-shifted carrier signal to a receiver. The frequency band to which the carrier signal is shifted is a band in which interference is minimal or non-existent. Further, the backscatter tag is able to operate in an ultra-low power manner, thereby allowing the tag to be incorporated into components like on-body sensors so that the tag can embed additional information into the carrier signal for transmission and processing by the receiver. Exemplary electronic circuits and systems that utilize a frequency-shifted Backscatter, as well as methods for implementing a frequency-shifted Backscatter, are also provided.
FILED	Friday, June 23, 2017
APPL NO	15/631142
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 1/0475 (20130101) H04B 17/318 (20150115) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/04 (20130101) Original (OR) Class
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RE047751 — Antisense oligonucleotides for inducing exon skipping and methods of use thereof

US RE47751	Wilton et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The University of Western Australia (Crawley, Australia)
ASSIGNEE(S)	The University of Western Australia (Crawley, Australia)
INVENTOR(S)	Stephen Donald Wilton (Applecross, Australia); Sue Fletcher (Bayswater, Australia); Graham McClorey (Bayswater, Australia)
ABSTRACT	An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
FILED	Thursday, July 20, 2017
APPL NO	15/655646
ART UNIT	3991 — Central Reexamination Unit (Chemical)
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/33 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/3233 (20130101) C12N 2310/3341 (20130101) C12N 2310/3519 (20130101) C12N 2320/30 (20130101) C12N 2320/33 (20130101)
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Department of Energy (DOE)

10493153 — Alkylated photoremovable protecting groups and uses thereof

US 10493153	Winter
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
INVENTOR(S)	Arthur Henry Winter (Ames, Iowa)
ABSTRACT	The invention relates to a method for photoreleasing a moiety G from a compound of the formula A-G. The methods of the present invention comprise irradiating a composition comprising the compound of the formula A-G at a wavelength of >500 nm, so as to photorelease the moiety G from the moiety A; wherein the moiety A comprises a chromophore and the moiety G comprises an organic compound.
FILED	Monday, September 24, 2018
APPL NO	16/140218
ART UNIT	1622 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 41/0042 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/22 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101)
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10493525 — Lifting and removal device for additive manufacturing system

US 10493525	Barr
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Kansas City National Security Campus (KCNSC) NNSA Critical Mission Site Operated by Honeywell Federal Manufacturing and Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S)	HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
ASSIGNEE(S)	Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S)	Christian Barr (Kansas City, Missouri)
ABSTRACT	An attachment device for lifting and removing build plates and additive manufactured parts built on the build plates from an additive manufacturing machine. The attachment device may fit onto a lift trolley to cooperatively engage with and lift the build plate upward off of a surface of the additive manufacturing machine. The attachment device may include a support bar, two lifting arms, and a mounting bracket. The support bar may have a slider track formed therethrough, so that the lifting arms can be adjusted to correspond with a width of the build plate. The lifting arms may each having a channel formed along a length thereof and an interfacing portion slidably located within the slider track. The channels may be sized and shaped to engage with a bottom surface and/or opposing edges of the build plates. The mounting bracket may attach to a lifting device of the lift trolley.
FILED	Tuesday, May 10, 2016
APPL NO	15/151266
ART UNIT	3652 — Material and Article Handling
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/005 (20130101) Original (OR) Class B22F 3/008 (20130101) B22F 3/1055 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/379 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/00 (20141201) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/295 (20151101)
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10493693 — 3D-printed apparatus for efficient fluid-solid contact

US 10493693	Robinson
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	David Robinson (Hayward, California)
ABSTRACT	Additively manufactured monolithic structures for containing and directing flows of fluids are described herein, which can achieve high contact area between fluids and solids while maintaining uniform flow conditions and requiring low applied pressures to yield desired flow rates, for use in heat exchangers, chromatography columns, catalytic converters, etc. An exemplary monolithic structure comprises a plurality of tiled unit cells having a same shape, where the tiled unit cells are integrally formed as a single component. The tiled unit cells are arranged to define one or more interior regions of fluid flow, one or more inlets to each interior region of fluid flow, and one or more outlets to each interior region of fluid flow. The structures and methods of tiling herein are suited to additive manufacturing technologies such as projection stereolithography, multiphoton lithography, etc.
FILED	Thursday, October 26, 2017
APPL NO	15/794413
ART UNIT	3649 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/153 (20170801) Original (OR) Class B29C 64/268 (20170801) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/046 (20130101)
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10494402 — Peptides that stimulate subcutaneous adipogenesis

US 10494402	Turley et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Eva A. Turley (London, Canada); Seyed Bahram Bahrami (Emeryville, California); Mina J. Bissell (Berkeley, California)
ABSTRACT	Peptides of 5 to 14 amino acids in length that stimulate subcutaneous adipogenesis in mammals and uses thereof are provided.
FILED	Monday, November 25, 2013
APPL NO	14/646298
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 8/64 (20130101) A61K 31/167 (20130101) A61K 38/00 (20130101) A61K 38/03 (20130101) A61K 38/08 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/001 (20130101) A61Q 19/08 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) Original (OR) Class C07K 14/70596 (20130101)
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10494470 — Post polymerization cure shape memory polymers

US 10494470	Wilson et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Thomas S. Wilson (San Leandro, California); Michael Keith Hearon (Boston, Massachusetts); Jane P. Bearinger (Berwyn, Pennsylvania)
ABSTRACT	This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape.
FILED	Wednesday, December 21, 2016
APPL NO	15/387256
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 48/00 (20190201) B29C 48/03 (20190201) B29C 51/00 (20130101) B29C 51/002 (20130101) B29C 61/06 (20130101) B29C 67/20 (20130101) B29C 71/02 (20130101) B29C 71/04 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/00 (20130101) B29K 2105/04 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/83 (20130101) C08G 18/673 (20130101) C08G 18/675 (20130101) C08G 18/722 (20130101) C08G 18/758 (20130101) C08G 18/3206 (20130101) Original (OR) Class C08G 63/52 (20130101) C08G 2101/00 (20130101) C08G 2280/00 (20130101)
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10494536 — Methods for preparation of concentrated graphene compositions and related composite materials

US 10494536	Hersam et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	Mark C. Hersam (Wilmette, Illinois); Yu Teng Liang (Chicago, Illinois)
ABSTRACT	A rapid, scalable methodology for graphene dispersion with a polymer-organic solvent solution and subsequent solvent exchange, as can be utilized without centrifugation, to enhance graphene concentration.
FILED	Monday, July 23, 2018
APPL NO	16/042251
ART UNIT	1764 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 32/174 (20170801) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/042 (20170501) C08K 3/042 (20170501) C08K 5/05 (20130101) C08K 5/10 (20130101) C08K 5/20 (20130101) C08K 5/3415 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/52 (20130101) C09D 101/28 (20130101) Original (OR) Class C09D 101/28 (20130101)
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10494555 — Encapsulation of thermal energy storage media

US 10494555	Goswami et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Dharendra Yogi Goswami (Tampa, Florida); Elias K. Stefanakos (Tampa, Florida); Chand K. Jotshi (Gainesville, Florida); Jaspreet Dhau (Tampa, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida)
INVENTOR(S)	Dharendra Yogi Goswami (Tampa, Florida); Elias K. Stefanakos (Tampa, Florida); Chand K. Jotshi (Gainesville, Florida); Jaspreet Dhau (Tampa, Florida)
ABSTRACT	In one embodiment, a method for fabricating a ceramic phase change material capsule includes forming a solid phase change material pellet, coating the pellet with a green ceramic material, and sintering the green ceramic material while on the pellet to form a ceramic outer shell of the capsule.
FILED	Friday, January 05, 2018
APPL NO	15/862983
ART UNIT	1767 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/04 (20130101) C09K 5/06 (20130101) C09K 5/063 (20130101) Original (OR) Class Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/00 (20130101)
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10494624 — Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods

US 10494624	Thompson et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE) Idaho National Laboratory (INL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
INVENTOR(S)	Vicki S. Thompson (Idaho Falls, Idaho); William A. Apel (Jackson, Wyoming); Jeffrey A. Lacey (Idaho Falls, Idaho); Brady D. Lee (West Richland, Washington); David W. Reed (Idaho Falls, Idaho); Francisco F. Roberto (Highlands Ranch, Colorado); David N. Thompson (Idaho Falls, Idaho)
ABSTRACT	Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering metabolism in a cell using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.
FILED	Friday, January 04, 2019
APPL NO	16/240411
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/00 (20130101) C12N 9/88 (20130101) Original (OR) Class C12N 9/1029 (20130101) C12N 15/74 (20130101) C12N 15/75 (20130101) Enzymes C12Y 203/01009 (20130101) C12Y 402/01055 (20130101)
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10494625 — Hybrid polyketide synthases

US 10494625	Fortman et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Jeffrey L. Fortman (San Francisco, California); Andrew Hagen (Berkeley, California); Leonard Katz (Oakland, California); Jay D. Keasling (Berkeley, California); Sean Poust (Berkeley, California); Jingwei Zhang (San Francisco, California); Sergey Zotchev (Tondheim, Norway)
ABSTRACT	The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
FILED	Monday, May 02, 2016
APPL NO	15/144727
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/44 (20130101) C12P 7/46 (20130101) C12P 13/001 (20130101) C12P 13/04 (20130101) C12P 13/005 (20130101) C12P 17/10 (20130101) C12P 17/186 (20130101) Enzymes C12Y 604/00 (20130101)
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10494721 — Electroless deposition of metal on 3D-printed polymeric structures

US 10494721	Robinson et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	David Robinson (Hayward, California); Christopher G. Jones (San Jose, California)
ABSTRACT	A process for metallizing a three-dimensional-printed polymeric structure includes soaking the three-dimensional-printed polymeric structure in a metal salt solution; transferring the three-dimensional polymeric structure to a solution comprising a first reducing agent; soaking the three-dimensional polymeric structure in a metal plating bath, the metal plating bath comprising a coordinating agent, a palladium or platinum salt, a pH buffer component, and a second reducing agent, to form a metal plated polymeric structure. A metal plated porous structure and an apparatus for improving metallization are also disclosed.
FILED	Tuesday, August 08, 2017
APPL NO	15/671345
ART UNIT	1717 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/31 (20130101) Original (OR) Class C23C 18/1641 (20130101) C23C 18/1648 (20130101)
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10494756 — Dryer appliances including an air circulation duct

US 10494756	Beers et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	Haier US Appliance Solutions, Inc. (Wilmington, Delaware); UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	Haier US Appliance Solutions, Inc. (Wilmington, Delaware); UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	David G. Beers (Elizabeth, Indiana); David Scott Dunn (Smithfield, Kentucky); Kyle R. Gluesenkamp (Knoxville, Tennessee); Philip R. Boudreaux (Knoxville, Tennessee); Bo Shen (Oakridge, Tennessee)
ABSTRACT	A dryer appliance including an air circulation duct is provided herein. The dryer appliance may also include a cabinet, a drum, an air handler, and a heat exchange section. The air circulation duct may define a recirculation loop with the drum. The air circulation duct may define a drum air inlet upstream from the drum and a drum air outlet downstream from the drum. The air circulation duct may further define a predetermined leakage port in fluid communication between the recirculation loop and the interior volume of the cabinet. The air handler may be disposed along the air circulation duct in fluid communication between the drum air outlet and the drum air inlet. The heat exchange section may be disposed along the air circulation duct in thermal communication with air within the recirculation loop.
FILED	Thursday, November 16, 2017
APPL NO	15/814474
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Laundering, Drying, Ironing, Pressing or Folding Textile Articles D06F 58/02 (20130101) D06F 58/10 (20130101) D06F 58/206 (20130101) Original (OR) Class D06F 2058/287 (20130101)
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10495388 — Thermal energy storage system with tunable phase change composition

US 10495388	Zheng et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	ADVANCED COOLING TECHNOLOGIES, INC. (Lancaster, Pennsylvania)
ASSIGNEE(S)	ADVANCED COOLING TECHNOLOGIES, INC. (Lancaster, Pennsylvania)
INVENTOR(S)	Ying Zheng (Lancaster, Pennsylvania); Chien-Hua Chen (Lititz, Pennsylvania); Howard Pearlman (Haddon Township, New Jersey); Richard Bonner, III (Lancaster, Pennsylvania); Fangyu Cao (Alexandria, Virginia)
ABSTRACT	A thermal energy storage system includes a phase change composition including a phase change material. The phase change composition has a first melting temperature at a first hydration level and a second melting temperature at a second hydration level. The phase change composition stores thermal energy by converting from a solid to a liquid. The thermal energy storage system also includes at least one compartment containing the phase change composition and at least one tuning medium receiving water to adjust the phase change composition from the first hydration level to the second hydration level and supplying water to adjust the phase change composition from the second hydration level to the first hydration level. A method of storing and releasing thermal energy is also disclosed.
FILED	Tuesday, August 29, 2017
APPL NO	15/689245
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/063 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/02 (20130101) Original (OR) Class
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10495573 — Instrument for measuring airborne particulate matter

US 10495573	Caubel et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	Julien J. Caubel (Emeryville, California); Troy E. Cados (Orinda, California); Thomas W. Kirchstetter (Berkeley, California)
ASSIGNEE(S)
INVENTOR(S)	Julien J. Caubel (Emeryville, California); Troy E. Cados (Orinda, California); Thomas W. Kirchstetter (Berkeley, California)
ABSTRACT	An apparatus for measuring the optical absorption of airborne matter or other light absorbing species in a sample airflow. The apparatus comprises a flow path through a fibrous filter to collect light absorbing species in the sampled air. The filtered airflow may subsequently pass through a second filter, used for reference measurements. At least one light source impinges in the filter generating one or two optical signals to determine the light absorption of particulate matter or other species in the sampled airflow. The apparatus includes at least one auxiliary sensor in the sample flow path to monitor an environmental factor, such as temperature. During a training period, a mathematical model of the apparatus' environmental sensitivity is derived. Using the mathematical model and measurements from the auxiliary sensor, optical signals are compensated in real time to increase the precision and accuracy of light absorption measurements recorded under fluctuating environmental conditions.
FILED	Wednesday, June 13, 2018
APPL NO	16/007513
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/61 (20130101) Original (OR) Class
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10495693 — Wind turbine fault detection using acoustic, vibration, and electrical signals

US 10495693	Unnikrishnan et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Jayakrishnan Unnikrishnan (Schenectady, New York); Lijun He (Schenectady, New York); Brett Alexander Matthews (Albany, New York); Liwei Hao (Niskayuna, New York)
ABSTRACT	Systems and methods for detecting faults are provided. A method for determining a fault condition for a component of a drivetrain in a wind turbine can include receiving an acoustic signal from an acoustic signal measuring device. The method can further include receiving a vibration signal from a vibration signal measuring device. The method can further include analyzing the acoustic signal to determine an analyzed acoustic signal. The method can further include analyzing the vibration signal to determine an analyzed vibration signal. The method can further include determining a fault condition for the component based at least in part on the analyzed acoustic signal and analyzed vibration signal. The fault condition can further be determined based at least in part on an analyzed electrical signal.
FILED	Thursday, June 01, 2017
APPL NO	15/610992
ART UNIT	2862 — Printing/Measuring and Testing
CURRENT CPC	Wind Motors F03D 7/0296 (20130101) F03D 17/00 (20160501) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2270/333 (20130101) F05B 2270/334 (20130101) Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 1/003 (20130101) G01H 3/12 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 31/34 (20130101) G01R 31/343 (20130101) Original (OR) Class
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10495750 — Spectral replacement to mitigate interference for multi-pass synthetic aperture radar

US 10495750	Musgrove et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Cameron Musgrove (Albuquerque, New Mexico); Richard M. Naething (Albuquerque, New Mexico); Douglas L. Bickel (Albuquerque, New Mexico)
ABSTRACT	Various technologies for mitigating interference artifacts in multi-pass synthetic aperture radar (SAR) imagery are described herein. First and second phase histories corresponding to first and second SAR passes over a scene are processed in image and phase-history domains to correct for spatially-variant and constant phase offsets between the phase histories that can be caused by known and unknown variations in motion of a SAR platform between passes. Data samples from one phase history can then be replaced with data samples from the other phase history to remove artifacts and distortions caused by sources of interference in the scene.
FILED	Tuesday, November 15, 2016
APPL NO	15/351949
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/904 (20190501) Original (OR) Class
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10496066 — System and apparatus for and methods of control of localized energy use in a building using price set points

US 10496066	Garg et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California); The International Institute of Information Technology (Telangana, India)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Vishal Garg (Telangana, India); Niranjan Reddy (Telangana, India); Sam Babu Godithi (Telangana, India); Richard E. Brown (Albany, California); Christian Kohler (Oakland, California); Reshma Singh (Palo Alto, California)
ABSTRACT	This disclosure provides systems, methods, and apparatus related to energy management in a building. In one aspect, a method includes providing a plurality of apparatus. Each apparatus of the plurality of apparatus includes a controller, a light, and a heating/cooling device. The controller is in communication with a control system, and the control system controls the electrical system of a building. A power price is received from the control system at a first apparatus of the plurality of apparatus. The power price is compared to a set point power price. Power supplied to at least one of the light of the first apparatus, the heating/cooling device of the first apparatus, a lighting device in a region proximate the first apparatus, and a heating/cooling device in the region proximate the first apparatus is adjusted based on comparing the power price to the set point power price.
FILED	Friday, August 18, 2017
APPL NO	15/681086
ART UNIT	2117 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/30 (20180101) F24F 11/46 (20180101) F24F 11/47 (20180101) F24F 11/62 (20180101) F24F 11/64 (20180101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/042 (20130101) G05B 19/048 (20130101) Original (OR) Class G05B 2219/2642 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/14 (20130101) H02J 13/00 (20130101) H02J 2003/146 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 70/3225 (20130101) Y02B 70/3241 (20130101) Y02B 70/3275 (20130101) Systems Integrating Technologies Related to Power Network Operation, Communication or Information Technologies for Improving the Electrical Power Generation, Transmission, Distribution, Management or Usage, i.e Smart Grids Y04S 20/222 (20130101) Y04S 20/224 (20130101) Y04S 20/227 (20130101) Y04S 20/244 (20130101)
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10497071 — Multi-domain situational awareness for infrastructure monitoring

US 10497071	Gosink et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Luke J. Gosink (Richland, Washington); Edwin R. Burtner (Richland, Washington); Jodi H. Obradovich (Tigard, Oregon); Scott T. Dowson (West Richland, Washington)
ABSTRACT	Apparatus and methods are disclosed for a monitoring system that integrates multi-domain data from weather, power, cyber, and/or social media sources to greatly increase situation awareness and drive more accurate assessments of reliability, sustainability, and efficiency in infrastructure environments, such as power grids. In one example of the disclosed technology, a method includes receiving real-time data from two or more different domains relevant to an infrastructure system, aggregating the real-time data into a unified representation relevant to the infrastructure system, and providing the unified representation to one or more customizable graphical user interfaces.
FILED	Wednesday, January 29, 2014
APPL NO	14/167807
ART UNIT	2448 — Computer Networks
CURRENT CPC	Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06 (20130101) G06Q 50/06 (20130101) Original (OR) Class
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10497259 — Traffic signal control using vehicle trajectory data

US 10497259	Liu et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Xianghong Liu (Ann Arbor, Michigan); Jianfeng Zheng (Ann Arbor, Michigan)
ABSTRACT	A system and method for use in controlling traffic signaling devices located along public roadways. The method carried out by the system includes: receiving, at one or more computers, time-location (TL) data from a plurality of wirelessly connected devices traveling through an intersection of a public roadway; determining, by the one or more computers using the received TL data, a traffic volume estimation value representative of a volume of traffic at the intersection; and sending the traffic volume estimation value to a traffic signaling control system configured to control a traffic signaling device at the intersection based on the traffic volume estimation value.
FILED	Friday, April 06, 2018
APPL NO	15/947454
ART UNIT	2687 — Dynamic Storage Systems; Mechanical parts of Disk Drives
CURRENT CPC	Traffic Control Systems G08G 1/08 (20130101) Original (OR) Class G08G 1/012 (20130101) G08G 1/0112 (20130101) G08G 1/0129 (20130101) G08G 1/0145 (20130101)
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10497482 — In-core instrumentation

US 10497482	Keller et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE)
APPLICANT(S)	NuScale Power, LLC (Corvallis, Oregon)
ASSIGNEE(S)	NUSCALE POWER, LLC (Portland, Oregon)
INVENTOR(S)	Michael Keller (Corvallis, Oregon); Ross T. Snuggerud (Corvallis, Oregon)
ABSTRACT	An in-core instrumentation system for a reactor module includes a plurality of in-core instruments connected to a containment vessel and a reactor pressure vessel at least partially located within the containment vessel. A reactor core is housed within a lower head that is removably attached to the reactor pressure vessel, and lower ends of the in-core instruments are located within the reactor core. The in-core instruments are configured such that the lower ends are concurrently removed from the reactor core as a result of removing the lower head from the reactor pressure vessel.
FILED	Friday, January 22, 2016
APPL NO	15/004128
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Nuclear Reactors G21C 1/08 (20130101) G21C 1/32 (20130101) G21C 13/02 (20130101) G21C 17/10 (20130101) G21C 19/02 (20130101) G21C 19/07 (20130101) G21C 19/18 (20130101) Original (OR) Class G21C 19/20 (20130101) G21C 19/32 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/40 (20130101)
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10497552 — Methods and systems for ion manipulation

US 10497552	Ibrahim et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Yehia M. Ibrahim (Richland, Washington); Aneesh Prabhakaran (Richland, Washington); Sandilya V. B. Garimella (Richland, Washington); Richard D. Smith (Richland, Washington); Ailin Li (Richland, Washington)
ABSTRACT	An ion manipulation device comprises a plurality of electrode rings arranged longitudinally adjacent to each other and defining a central axis therethrough. At least one electrode ring comprises a plurality of electrodes arranged in a first planar pattern. Electrodes are configured to periodically receive a voltage to generate a circular traveling wave that rotates around the electrodes of each electrode ring to confine ions within an interior of the apparatus.
FILED	Tuesday, August 14, 2018
APPL NO	16/103729
ART UNIT	2881 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/622 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/062 (20130101) H01J 49/063 (20130101) Original (OR) Class
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10497593 — Bi-metal foil for a beam intensity/position monitor, method for determining mass absorption coefficients

US 10497593	Alkire
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S)	Randy Alkire (Romeoville, Illinois)
ABSTRACT	The invention provides a beam intensity/positioning monitor substrate comprising a first metal foil in physical contact with a second metal foil. Also provided is a method for determining mass absorption coefficients, the method comprising measuring the absorption of an incident radiation beam by a first metal and a second metal comprising a bi-metal foil as a function of a first energy and a second energy; calculating the relative first metal thickness; using the relative thickness as a target value for the first metal fitting procedure; repeat the above steps on a free standing first metal foil; using the free standing first metal absorption measurements, bulk first metal density and first (bimetal) fit coefficients to determine first metal foil thickness; using free standing first metal to conduct a high resolution scan from just below its absorption edge to 1 keV or higher in energy; and using the free standing first metal absorption measurements below the absorption edge and experimentally determined thickness to compute mass absorption coefficients below its absorption edge.
FILED	Friday, August 18, 2017
APPL NO	15/680954
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/0204 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/2008 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/3005 (20130101) H01J 37/3174 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/67253 (20130101) Original (OR) Class H01L 31/02 (20130101) H01L 31/16 (20130101) H01L 31/03365 (20130101)
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10497633 — Stretchable electronic systems with fluid containment

US 10497633	Rogers et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Materials Sciences and Engineering Division (MSE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS) Office of The Director (OD) Office of International Science and Engineering (OISE)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	John A. Rogers (Champaign, Illinois); Sheng Xu (Urbana, Illinois); Jonathan A. Fan (Columbus, Ohio); Lin Jia (Boston, Massachusetts)
ABSTRACT	The present invention provides electronic systems, including device arrays, comprising functional device(s) and/or device component(s) at least partially enclosed via one or more fluid containment chambers, such that the device(s) and/or device component(s) are at least partially, and optionally entirely, immersed in a containment fluid. Useful containment fluids for use in fluid containment chambers of electronic devices of the invention include lubricants, electrolytes and/or electronically resistive fluids. In some embodiments, for example, electronic systems of the invention comprise one or more electronic devices and/or device components provided in free-standing and/or tethered configurations that decouple forces originating upon deformation, stretching or compression of a supporting substrate from the free standing or tethered device or device component.
FILED	Friday, March 15, 2013
APPL NO	13/835284
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/08 (20130101) H01L 23/18 (20130101) Original (OR) Class H01L 23/22 (20130101) H01L 2224/16225 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/12032 (20130101) H01L 2924/12032 (20130101) H01L 2924/12041 (20130101) H01L 2924/12041 (20130101) H01L 2924/12042 (20130101) H01L 2924/12042 (20130101) H01L 2924/12043 (20130101) H01L 2924/12043 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 6/40 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0283 (20130101)
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10497866 — Ionic floating-gate memory device

US 10497866	Fuller et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Elliot James Fuller (Dublin, California); Sapan Agarwal (Dublin, California); Albert Alec Talin (Dublin, California)
ABSTRACT	A non-volatile memory device is described herein. The non-volatile memory device includes a diffusive memristor electrically coupled to a redox transistor. The redox transistor includes a gate, a source, and a drain, wherein the gate comprises a first storage element that acts as an ion reservoir, and a channel between the source and the drain comprises a second storage element, wherein a state of the memory device is represented by conductance of the second storage element.
FILED	Tuesday, June 19, 2018
APPL NO	16/012430
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Static Stores G11C 13/0007 (20130101) G11C 13/0009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/2427 (20130101) H01L 45/1206 (20130101) Original (OR) Class
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10497927 — Methods of applying self-forming artificial solid electrolyte interface (SEI) layer to stabilize cycle stability of electrodes in lithium batteries

US 10497927	Xiao
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	GM Global Technology Operations LLC (Detroit, Michigan)
ASSIGNEE(S)	GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
INVENTOR(S)	Xingcheng Xiao (Troy, Michigan)
ABSTRACT	A method of making a negative electrode for an electrochemical cell includes applying a fluoropolymer via a deposition process to one or more surface regions of an electroactive material. The electroactive material may be selected from the group consisting of: lithium metal, silicon metal, silicon-containing alloys, and combinations thereof. The fluoropolymer reacts with lithium to form a composite surface layer on the one or more surface regions that comprises an organic matrix material having lithium fluoride particles distributed therein. Electrochemical cells including such negative electrode are also provided.
FILED	Thursday, August 31, 2017
APPL NO	15/692107
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/386 (20130101) H01M 4/0421 (20130101) Original (OR) Class H01M 4/602 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101)
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10497971 — Metal-organic framework electrodes for sodium ion batteries

US 10497971	Sava Gallis et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Dorina F. Sava Gallis (Albuquerque, New Mexico); Harry Pratt (Albuquerque, New Mexico); Travis Mark Anderson (Albuquerque, New Mexico); Nicholas Hudak (Washington, District of Columbia)
ABSTRACT	A sodium ion battery comprises a cathode having a porous redox active metal-organic framework material. The battery can be an organic electrolyte sodium ion battery wherein the electrolyte comprises a sodium salt dissolved in an organic solvent or mixture of organic solvents. Alternatively, the battery can comprise an aqueous sodium ion battery wherein the electrolyte comprises a sodium salt dissolved in an aqueous solvent. Battery performance is especially related to electrolyte and binder selection.
FILED	Thursday, April 18, 2019
APPL NO	16/388217
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 13/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) Polysaccharides; Derivatives Thereof C08B 11/12 (20130101) Compositions of Macromolecular Compounds C08L 1/286 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/022 (20130101) H01M 2/0222 (20130101) H01M 4/381 (20130101) H01M 4/382 (20130101) H01M 4/623 (20130101) H01M 10/0564 (20130101) Original (OR) Class H01M 10/0565 (20130101)
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10498141 — Distributed hierarchical control architecture for integrating smart grid assets during normal and disrupted operations

US 10498141	Kalsi et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Karanjit Kalsi (Richland, Washington); Jason C. Fuller (Richland, Washington); Abhishek Somani (Richland, Washington); Robert G. Pratt (Kennewick, Washington); David P. Chassin (Pasco, Washington); Donald J. Hammerstrom (West Richland, Washington)
ABSTRACT	Disclosed herein are representative embodiments of methods, apparatus, and systems for facilitating operation and control of a resource distribution system (such as a power grid). Among the disclosed embodiments is a distributed hierarchical control architecture (DHCA) that enables smart grid assets to effectively contribute to grid operations in a controllable manner, while helping to ensure system stability and equitably rewarding their contribution. Embodiments of the disclosed architecture can help unify the dispatch of these resources to provide both market-based and balancing services.
FILED	Thursday, August 31, 2017
APPL NO	15/693413
ART UNIT	2117 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Systems for Regulating Electric or Magnetic Variables G05F 5/00 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/00 (20130101) H02J 3/06 (20130101) H02J 3/008 (20130101) H02J 3/16 (20130101) Original (OR) Class H02J 3/381 (20130101) H02J 3/382 (20130101) H02J 13/0006 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 40/72 (20130101) Systems Integrating Technologies Related to Power Network Operation, Communication or Information Technologies for Improving the Electrical Power Generation, Transmission, Distribution, Management or Usage, i.e Smart Grids Y04S 10/12 (20130101) Y04S 10/123 (20130101) Y04S 50/10 (20130101)
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National Science Foundation (NSF)

10492703 — Epidermal sensor system and process

US 10492703	Lu et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Nanshu Lu (Austin, Texas); Shixuan Yang (Austin, Texas); Pulin Wang (Austin, Texas)
ABSTRACT	Epidermal electronics are sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate. Also, a stretchable planar coil made of serpentine ribbons can be used as a wireless strain gauge and/or a near field communication (NFC) antenna. Other embodiments are described herein.
FILED	Friday, March 27, 2015
APPL NO	14/671554
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/085 (20130101) A61B 5/0408 (20130101) Original (OR) Class A61B 5/0492 (20130101) A61B 5/0537 (20130101) A61B 5/6833 (20130101) A61B 2562/125 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 35/02 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2067/003 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/753 (20130101)
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10492860 — Microwave ablation antenna system with tapered slot balun

US 10492860	Hagness et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Susan C. Hagness (Madison, Wisconsin); Nader Behdad (Oregon, Wisconsin); Hung Thanh Luyen (Madison, Wisconsin)
ABSTRACT	A balun includes a center conductor, a dielectric material, a tapered wall, a ring, and a prong. The center conductor extends a length of the balun. The dielectric material surrounds the center conductor along the length of the balun. The tapered wall forms a portion of a tube between a first wall and a second wall. The first wall is opposite the second wall. The tapered wall is formed of a conductive material. The portion of the tube forms a slot exposing the dielectric material. The ring connects to the second wall of the tapered wall and is formed of the conductive material. The ring forms a tube surrounding the center conductor and the dielectric material. The prong connects to the ring to extend toward the first wall and is formed of the conductive material. The prong extends over a portion of the dielectric material exposed by the slot.
FILED	Thursday, March 09, 2017
APPL NO	15/454218
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/1815 (20130101) Original (OR) Class A61B 2018/00577 (20130101) A61B 2018/1838 (20130101) A61B 2018/1861 (20130101) A61B 2018/1892 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/72 (20130101)
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10493153 — Alkylated photoremovable protecting groups and uses thereof

US 10493153	Winter
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
INVENTOR(S)	Arthur Henry Winter (Ames, Iowa)
ABSTRACT	The invention relates to a method for photoreleasing a moiety G from a compound of the formula A-G. The methods of the present invention comprise irradiating a composition comprising the compound of the formula A-G at a wavelength of >500 nm, so as to photorelease the moiety G from the moiety A; wherein the moiety A comprises a chromophore and the moiety G comprises an organic compound.
FILED	Monday, September 24, 2018
APPL NO	16/140218
ART UNIT	1622 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 41/0042 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/22 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101)
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10493263 — Onychomycosis treatment system and method

US 10493263	Roe et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF)
APPLICANT(S)	DEVICEFARM, INC. (Newark, California)
ASSIGNEE(S)
INVENTOR(S)	Jeffrey N Roe (Pleasanton, California); Timothy C Grammer (Pleasant Hill, California); Eric Tridas (St. Petersburg, Florida); Raul Ignacio Barrera-Barraza (Fremont, California); Joel Sterling Douglas (Bonita Springs, Florida)
ABSTRACT	A system and method includes delivery of a redox gas solution to treat onychomycosis, wherein the redox gas solution comprises a reactive species dissolved in a perfluorocarbon liquid, and wherein the perfluorocarbon liquid is dispensed onto a gas-permeable membrane and the perfluorocarbon liquid comprises of an anti-inflammatory in a perfluorocarbon liquid and wherein the reactive species may include, alone or in combination, one or more of reactive oxygen, reactive nitrogen, reactive chlorine, or reactive bromine species, and the perfluorocarbon liquid may include perfluorodecalin.
FILED	Thursday, August 10, 2017
APPL NO	15/674120
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/18 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/068 (20130101) A61F 13/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/02 (20130101) A61K 33/04 (20130101) A61K 33/20 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/44 (20130101) A61N 1/0428 (20130101) Original (OR) Class
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10493431 — Nanodiamond supported catalytic nanoparticles and associated methods

US 10493431	Shumaker-Parry et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Jennifer S. Shumaker-Parry (Salt Lake City, Utah); Arthur D. Quast (Salt Lake City, Utah)
ABSTRACT	A catalytic nanoparticle can include a nanodiamond core, a thin-layer polymeric film applied to an outer surface of the nanodiamond core, and a catalyst immobilized at an outer surface of the thin-layer polymeric film. The nanoparticles can also be used in connection with a transducer to form a sensor. A method of catalysis can include contacting the catalytic nanoparticle with a reactant in a reaction area. The reactant can be capable of forming a reaction product via a reaction catalyzed by the catalyst. The method of catalysis can also include facilitating a catalytic interaction between the catalytic nanoparticle and the reactant.
FILED	Wednesday, August 30, 2017
APPL NO	15/691505
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) Original (OR) Class B01J 23/42 (20130101) B01J 23/44 (20130101) B01J 23/52 (20130101) B01J 31/003 (20130101) B01J 31/06 (20130101) B01J 35/002 (20130101) B01J 35/0006 (20130101) B01J 35/006 (20130101) B01J 35/0013 (20130101) B01J 37/04 (20130101) B01J 37/0219 (20130101) B01J 37/0221 (20130101) B01J 37/0244 (20130101) B01J 37/345 (20130101) B01J 2231/005 (20130101) B01J 2231/641 (20130101) B01J 2531/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/127 (20130101) G01N 31/10 (20130101)
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10493432 — Photocatalyst / carbon nanotube aerogel composites

US 10493432	Islam et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	Carnegie Mellon University (Pittsburgh, Pennsylvania)
INVENTOR(S)	Mohammad F. Islam (Pittsburgh, Pennsylvania); Paul A. Salvador (Pittsburgh, Pennsylvania); Gregory S. Rohrer (Pittsburgh, Pennsylvania)
ABSTRACT	Forming a photocatalyst/aerogel composite includes contacting an aerogel including a porous carbon nanotube network with a solution including a photocatalyst precursor to yield a wet gel. The porous carbon nanotube network includes carbon nanotubes, nodes, and struts. Each node is defined by a region in which two of the carbon nanotubes are in direct contact with each other, and each strut is defined by one of the carbon nanotubes extending between a first node and a second node. Forming the photocatalyst/aerogel composite further includes initiating a chemical reaction in the wet gel to form, on the nodes and struts, photocatalyst nanoparticles from the photocatalyst precursor, and removing liquid from the wet gel to yield an aerogel composite defining pores and including the photocatalyst nanoparticles. The photocatalyst nanoparticles are covalently bonded to the nodes and the struts throughout the porous carbon nanotube network.
FILED	Friday, February 16, 2018
APPL NO	15/932257
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/063 (20130101) B01J 21/185 (20130101) B01J 23/42 (20130101) Original (OR) Class B01J 35/02 (20130101) B01J 35/004 (20130101) B01J 35/0006 (20130101) B01J 35/006 (20130101) B01J 35/0013 (20130101) B01J 37/035 (20130101) B01J 37/036 (20130101)
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10493488 — Methods and formulations for durable superhydrophic, self-cleaning, and superhydrophobic polymer coatings and objects having coatings thereon

US 10493488	Constantinou et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Geosciences (GEO) Division of Earth Sciences (EAR) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR) Nanoscale Science and Engineering Centers (NSF-NSEC)
APPLICANT(S)	UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
ASSIGNEE(S)	The University of Masachusetts (Boston, Massachusetts)
INVENTOR(S)	Jason Constantinou (Beaverton, Oregon); Hanna Dodiuk-Kenig (Haifa, Israel); Carol M. F. Barry (Tyngsborough, Massachusetts); Samuel Kenig (Haifa, Israel); Joey L. Mead (Carlisle, Massachusetts); Artee Panwar (Wilmington, Massachusetts); Tehila Nahum (Holon, Israel); Sagar Mitra (Lowell, Massachusetts)
ABSTRACT	An object has a durable superhydrophic, self-cleaning, and icephobic coating includes a substrate and a layer disposed on the substrate, the layer resulting from coating with a formulation having an effective amount of hierarchical structuring micro/nanoparticles, liquid silane having one or more groups configured to graft to a hierarchical structuring micro/nanoparticle and at least another group that results in hydrophobicity. The hierarchical structuring micro/nanoparticles are dispersed in the liquid silane. Another effective amount of synthetic adhesive, selected from thermosetting binders, moisture curing adhesives or polymers that form a strong interaction with a surface, is in solution with a solvent. Upon curing, the layer has a contact angle greater than 90° and a sliding angle of less than 10° and, less than 5% of an area of the layer is removed in a Tape test.
FILED	Friday, April 17, 2015
APPL NO	15/304242
ART UNIT	1715 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 3/067 (20130101) B05D 3/0254 (20130101) B05D 5/00 (20130101) B05D 5/08 (20130101) Original (OR) Class B05D 5/083 (20130101) B05D 2601/22 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 59/022 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2827/18 (20130101) B29K 2863/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/00 (20130101) C09D 7/69 (20180101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/10 (20130101) C25D 1/20 (20130101)
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10493509 — Spiral forming

US 10493509	Smith et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Keystone Tower Systems, Inc. (Westminster, Colorado)
ASSIGNEE(S)	Keystone Tower Systems, Inc. (Westminster, Colorado)
INVENTOR(S)	Eric D. Smith (Denver, Colorado); Rosalind K. Takata (Denver, Colorado); Daniel Ainge (Boulder, Colorado); Loren Daniel Bridgers (Golden, Colorado)
ABSTRACT	Spiral forming methods can be used to join edges of a rolled material along a spiral joint to form conical and/or cylindrical structures. Alignment of the edges of the rolled material can be controlled in a wrapping direction as the material is being joined along the spiral joint to form the structure. By controlling alignment of the edges of the material as the edges of the material are being joined, small corrections can be made over the course of forming the structure facilitating control over geometric tolerances of the resulting spiral formed structure.
FILED	Friday, June 24, 2016
APPL NO	15/191841
ART UNIT	3725 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/12 (20130101) B21C 37/122 (20130101) B21C 37/124 (20130101) B21C 37/128 (20130101) Original (OR) Class B21C 37/185 (20130101) Wind Motors F03D 13/20 (20160501) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/912 (20130101)
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10493634 — Robotic end effectors for use with robotic manipulators

US 10493634	Alqasemi et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	University of South Florida (Tampa, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida)
INVENTOR(S)	Redwan Alqasemi (Wesley Chapel, Florida); Paul Mitzlaff (Palm Harbor, Florida); Andoni Aguirrezabal (Tampa, Florida); Lei Wu (Tampa, Florida); Karl Rothe (Rockledge, Florida); Rajiv Dubey (Tampa, Florida)
ABSTRACT	In one embodiment, a robotic end effector configured to mount to a robotic manipulator includes gripping elements configured to grasp objects, a drive mechanism configured to open and close the gripping elements, and a central controller configured to control operation of the drive mechanism and the gripper elements, the central controller hosting a control program that enables control of the end effector independent of the robotic manipulator.
FILED	Tuesday, October 02, 2018
APPL NO	16/149652
ART UNIT	3652 — Material and Article Handling
CURRENT CPC	Manipulators; Chambers Provided With Manipulation Devices B25J 15/022 (20130101) B25J 15/0038 (20130101) Original (OR) Class
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10494315 — Method for making a novel nanocomposite for combustion applications

US 10494315	Buckner et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Steven Wayne Buckner (St. Louis, Missouri); Paul Jelliss (St. Louis, Missouri); Stephen Chung (Florissant, Missouri); Jacob M Laktas (St. Louis, Missouri); Gregory J Place (St. Louis, Missouri)
ASSIGNEE(S)	SAINT LOUIS UNIVERSITY (Saint Louis, Missouri)
INVENTOR(S)	Steven Wayne Buckner (St. Louis, Missouri); Paul Jelliss (St. Louis, Missouri); Stephen Chung (Florissant, Missouri); Jacob M Laktas (St. Louis, Missouri); Gregory J Place (St. Louis, Missouri)
ABSTRACT	The present invention generally concerns a method for isolating nanoparticles via the decomposition of a ternary metal hydride. More specifically, the present invention harnesses increased energy densities from two distinct nanoparticles isolated by a precise decomposition of LiAlH₄. The singular material is air stable and is a nanocomposite of Li₃AlH₆nanoparticles, elemental Al nanoparticles, an amount of Ti metal, and a nanoscale organic layer, which we call nMx. The nanocomposite protects and preserves the high energy densities of the core metals isolated from the controlled reaction and makes the nanoparticles safe to handle in air. The final composite is devoid of byproducts or phase transitions that will decrease the energy output of the nanocomposite. The method of the present invention creates a narrow distribution of nanoparticles that have unique burning characteristics useful for many applications.
FILED	Monday, August 14, 2017
APPL NO	15/675815
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/08 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 45/32 (20130101) Original (OR) Class Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/81 (20130101) Y10S 977/773 (20130101) Y10S 977/896 (20130101)
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10494328 — Amination and hydroxylation of arylmetal compounds

US 10494328	Gao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) Non-Profit Organization (NPO) Robert A. Welch Foundation National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	WILLIAM MARSH RICE UNIVERSITY (Houston, Texas)
ASSIGNEE(S)	William Marsh Rice University (Houston, Texas)
INVENTOR(S)	Hongyin Gao (Houston, Texas); Zhe Zhou (Houston, Texas); Laszlo Kurti (Bellaire, Texas)
ABSTRACT	In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.
FILED	Tuesday, July 25, 2017
APPL NO	15/659320
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	General Methods of Organic Chemistry; Apparatus Therefor C07B 41/02 (20130101) C07B 43/04 (20130101) Acyclic or Carbocyclic Compounds C07C 37/01 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/64 (20130101) C07C 37/64 (20130101) C07C 39/12 (20130101) C07C 39/14 (20130101) C07C 39/15 (20130101) C07C 39/20 (20130101) C07C 39/205 (20130101) C07C 39/235 (20130101) C07C 41/26 (20130101) C07C 41/26 (20130101) C07C 43/23 (20130101) C07C 209/66 (20130101) Original (OR) Class C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 211/44 (20130101) C07C 211/47 (20130101) C07C 211/51 (20130101) C07C 211/58 (20130101) C07C 211/59 (20130101) C07C 211/61 (20130101) C07C 213/02 (20130101) C07C 213/02 (20130101) C07C 213/02 (20130101) C07C 213/02 (20130101) C07C 217/80 (20130101) C07C 217/94 (20130101) C07C 219/34 (20130101) C07C 227/06 (20130101) C07C 227/06 (20130101) C07C 227/06 (20130101) C07C 229/56 (20130101) C07C 229/60 (20130101) C07C 303/30 (20130101) C07C 303/30 (20130101) C07C 309/30 (20130101) C07C 319/20 (20130101) C07C 319/20 (20130101) C07C 323/36 (20130101) C07C 2601/02 (20170501) C07C 2601/04 (20170501) C07C 2601/14 (20170501) C07C 2603/18 (20170501) C07C 2603/26 (20170501) Heterocyclic Compounds C07D 209/04 (20130101) C07D 209/88 (20130101) C07D 213/04 (20130101) C07D 213/73 (20130101) C07D 215/38 (20130101) C07D 277/82 (20130101) C07D 295/096 (20130101) C07D 295/135 (20130101) C07D 307/79 (20130101) C07D 307/91 (20130101) C07D 309/12 (20130101) C07D 311/58 (20130101) C07D 317/20 (20130101) C07D 317/28 (20130101) C07D 317/46 (20130101) C07D 317/64 (20130101) C07D 317/66 (20130101) C07D 333/16 (20130101) C07D 333/20 (20130101) C07D 333/36 (20130101) Steroids C07J 41/0011 (20130101)
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10494395 — Base metal catalyzed borylation of arenes and aromatic heterocycles

US 10494395	Chirik et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Paul J. Chirik (Princeton, New Jersey); Scott Semproni (Portland, Oregon); Jennifer Obligacion (Edison, New Jersey); Margaret Scheuermann (Plainsboro, New Jersey)
ABSTRACT	In one aspect, cobalt complexes are described herein. In some embodiments, such cobalt complexes employ bis(phosphine) or bis(imine) ligand and are operable as catalysts for borylation of arenes and aromatic heterocycles.
FILED	Tuesday, December 09, 2014
APPL NO	15/103200
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/065 (20130101) Original (OR) Class
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10494538 — Switchable antimicrobial and antifouling carboxybetaine-based hydrogels and elastomers with enhanced mechanical properties

US 10494538	Cheng et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	Gang Cheng (Fairlawn, Ohio); Bin Cao (Akron, Ohio)
ASSIGNEE(S)	THE UNIVERSITY OF AKRON (Akron, Ohio)
INVENTOR(S)	Gang Cheng (Fairlawn, Ohio); Bin Cao (Akron, Ohio)
ABSTRACT	Various embodiments of the present invention are directed to switchable carboxybetaine-based polymers, hydrogels, and/or elastomers, along with novel related monomers, crosslinkers, and methods. Under acidic conditions, the materials undergo self-cyclization and can catch and kill bacteria. Under neutral/basic conditions, these materials undergo ring-opening and can release killed bacterial cells and resist protein adsorption and bacterial attachment. These smart polymers, hydrogels and elastomers also show excellent mechanical properties making them highly desirable for many biomedical applications.
FILED	Friday, May 30, 2014
APPL NO	14/893561
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/12 (20130101) Acyclic or Carbocyclic Compounds C07C 227/02 (20130101) C07C 227/16 (20130101) C07C 227/18 (20130101) C07C 229/12 (20130101) C07C 233/38 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 20/34 (20130101) C08F 20/36 (20130101) C08F 22/385 (20130101) C08F 120/36 (20130101) C08F 220/36 (20130101) C08F 222/385 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) C09D 133/14 (20130101) Original (OR) Class C09D 133/26 (20130101) C09D 139/00 (20130101)
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10494610 — Three dimensional matrix for cancer stem cells

US 10494610	Jabbari
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina)
ASSIGNEE(S)	University of South Carolina (Columbia, South Carolina)
INVENTOR(S)	Esmaiel Jabbari (Columbia, South Carolina)
ABSTRACT	Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.
FILED	Friday, November 30, 2018
APPL NO	16/205489
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0695 (20130101) Original (OR) Class C12N 2533/30 (20130101) C12N 2537/10 (20130101)
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10494625 — Hybrid polyketide synthases

US 10494625	Fortman et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Jeffrey L. Fortman (San Francisco, California); Andrew Hagen (Berkeley, California); Leonard Katz (Oakland, California); Jay D. Keasling (Berkeley, California); Sean Poust (Berkeley, California); Jingwei Zhang (San Francisco, California); Sergey Zotchev (Tondheim, Norway)
ABSTRACT	The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
FILED	Monday, May 02, 2016
APPL NO	15/144727
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/44 (20130101) C12P 7/46 (20130101) C12P 13/001 (20130101) C12P 13/04 (20130101) C12P 13/005 (20130101) C12P 17/10 (20130101) C12P 17/186 (20130101) Enzymes C12Y 604/00 (20130101)
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10494664 — Methods and compositions for detecting a target RNA

US 10494664	Doudna et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Jennifer A. Doudna (Berkeley, California); Mitchell Ray O'Connell (Oakland, California); Alexandra East-Seletsky (San Francisco, California); Spencer Charles Knight (Berkeley, California); James Harrison Doudna Cate (Berkeley, California)
ABSTRACT	The present disclosure provides methods for detecting a single-stranded target RNA. The present disclosure provides methods of cleaving a precursor C2c2 guide RNA array into two or more C2c2 guide RNAs. The present disclosure provides a kit for detecting a target RNA in a sample.
FILED	Tuesday, March 13, 2018
APPL NO	15/920222
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) Original (OR) Class C12Q 1/6823 (20130101) C12Q 2521/327 (20130101) Technologies for Adaptation to Climate Change Y02A 50/53 (20180101) Y02A 50/54 (20180101) Y02A 50/57 (20180101) Y02A 50/58 (20180101) Y02A 50/60 (20180101)
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10495703 — Systems, apparatus, and methods of nonlinear terahertz (THz) magnetic resonance measurement

US 10495703	Hwang et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Harold Young Hwang (Cambridge, Massachusetts); Jian Lu (Medford, Massachusetts); Yaqing Zhang (Cambridge, Massachusetts); Benjamin K. Ofori-Okai (Cambridge, Massachusetts); Keith A. Nelson (Newton, Massachusetts); Xian Li (Cambridge, Massachusetts)
ABSTRACT	A nonlinear terahertz (THz) spectroscopy technique uses a sample illuminated by two THz pulses separately. The illumination generates two signals B_Aand B_B, corresponding to the first and second THz pulse, respectively, after interaction with the sample. The interaction includes excitation of at least one ESR transition in the sample. The sample is also illuminated by the two THz pulses together, with an inter-pulse delay τ, generating a third signal B_AB. A nonlinear signal BNL is then derived via B_NL=B_AB−B_A−B_B. This nonlinear signal B_NLcan be then processed (e.g., Fourier transform) to study the properties of the sample.
FILED	Friday, March 09, 2018
APPL NO	15/917198
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/10 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) Original (OR) Class G01R 33/60 (20130101) G01R 33/323 (20130101)
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10495859 — Head-mounted projection display using reflective microdisplays

US 10495859	Hua et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona)
ASSIGNEE(S)	THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona)
INVENTOR(S)	Hong Hua (Tucson, Arizona); Rui Zhang (Kirkland, Washington)
ABSTRACT	The present invention relates generally to a head-mounted projection display, and more particularly, but not exclusively to a polarized head-mounted projection display including a light engine and a compact, high-performance projection lens for use with reflective microdisplays.
FILED	Thursday, October 25, 2018
APPL NO	16/170860
ART UNIT	2878 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 5/30 (20130101) G02B 5/3083 (20130101) G02B 9/34 (20130101) G02B 13/004 (20130101) G02B 13/04 (20130101) G02B 13/16 (20130101) G02B 13/22 (20130101) Original (OR) Class G02B 13/0065 (20130101) G02B 27/0172 (20130101) G02B 27/286 (20130101) G02B 2027/0118 (20130101) G02B 2027/0123 (20130101)
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10496052 — Systems, methods and devices for vector control of induction machines using artificial neural networks

US 10496052	Fu et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Board of Trustees of the University of Alabama (Tuscaloosa, Alabama)
ASSIGNEE(S)	The Board of Trustees of the University of Alabama (Tuscaloosa, Alabama)
INVENTOR(S)	Xingang Fu (Tuscaloosa, Alabama); Shuhui Li (Northport, Alabama)
ABSTRACT	Described herein is a neural network-based vector control method for the induction motor. The disclosure includes an approach to implement optimal vector control for an induction motor by using an NN; a NN controller to substitute two decoupled proportional-integral (PI) controllers in current loop; and, a mechanism to train the NN controller by using a Levenberg-Marquardt (LM)+forward accumulation through time (FATT) algorithm.
FILED	Monday, April 11, 2016
APPL NO	15/095333
ART UNIT	2115 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) Original (OR) Class Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 6/34 (20160201) H02P 21/14 (20130101) H02P 2207/01 (20130101)
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10496552 — Trusted computing system with enhanced memory

US 10496552	Narayanasamy et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Massachusetts)
INVENTOR(S)	Satish Narayanasamy (Ann Arbor, Michigan); Shaizeen Aga (Ann Arbor, Michigan)
ABSTRACT	A system that executes private enclave functions in a secure high-performance host processor connected to an enhanced memory unit through a conventional memory bus using a packetized interface is disclosed. The logic layer of the enhanced memory unit is included in a trusted computing base (TCB) and is used to implement cryptographic functions. Storage layers of the enhanced memory unit remain outside the TCB and are used to store encrypted data and associated meta-data.
FILED	Wednesday, April 12, 2017
APPL NO	15/485860
ART UNIT	2491 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 12/1408 (20130101) Original (OR) Class G06F 13/16 (20130101) G06F 13/4068 (20130101) G06F 13/4282 (20130101) G06F 21/602 (20130101) G06F 2212/402 (20130101) G06F 2212/1052 (20130101)
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10497275 — Systems and methods for inquiry-based learning including collaborative question generation

US 10497275	Kim
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Hong Suk Kim (Palo Alto, California)
ABSTRACT	Systems and methods in accordance with embodiments of the invention utilize technology to facilitate student question creation. Interactive platforms such as mobile phones or tablets can allow questions to be written, saved, and communicated electronically. In one embodiment, a method for collaboratively generating a question includes generating question data in response to input of a question and answer choices on a first device, sending the question data to a repository, sending the question data from the repository to a second device, displaying the question and answer choices on the second device, generating revised question data in response to input that changes the question, sending the revised question data to the repository, sending the revised question data to a third device, displaying the question and answer choices on the third device, receiving input of the selection of answer choices on the third device, and providing feedback whether the selection is correct.
FILED	Tuesday, October 02, 2018
APPL NO	16/150057
ART UNIT	2455 — Computer Networks
CURRENT CPC	Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/101 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 7/07 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 12/1827 (20130101)
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10497633 — Stretchable electronic systems with fluid containment

US 10497633	Rogers et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Materials Sciences and Engineering Division (MSE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS) Office of The Director (OD) Office of International Science and Engineering (OISE)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	John A. Rogers (Champaign, Illinois); Sheng Xu (Urbana, Illinois); Jonathan A. Fan (Columbus, Ohio); Lin Jia (Boston, Massachusetts)
ABSTRACT	The present invention provides electronic systems, including device arrays, comprising functional device(s) and/or device component(s) at least partially enclosed via one or more fluid containment chambers, such that the device(s) and/or device component(s) are at least partially, and optionally entirely, immersed in a containment fluid. Useful containment fluids for use in fluid containment chambers of electronic devices of the invention include lubricants, electrolytes and/or electronically resistive fluids. In some embodiments, for example, electronic systems of the invention comprise one or more electronic devices and/or device components provided in free-standing and/or tethered configurations that decouple forces originating upon deformation, stretching or compression of a supporting substrate from the free standing or tethered device or device component.
FILED	Friday, March 15, 2013
APPL NO	13/835284
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/08 (20130101) H01L 23/18 (20130101) Original (OR) Class H01L 23/22 (20130101) H01L 2224/16225 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/12032 (20130101) H01L 2924/12032 (20130101) H01L 2924/12041 (20130101) H01L 2924/12041 (20130101) H01L 2924/12042 (20130101) H01L 2924/12042 (20130101) H01L 2924/12043 (20130101) H01L 2924/12043 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 6/40 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0283 (20130101)
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10498342 — Discretely assembled logic blocks

US 10498342	Langford et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	William Kai Langford (Cambridge, Massachusetts); Amanda Ghassaei (Cambridge, Massachusetts); Neil Gershenfeld (Cambride, Massachusetts)
ABSTRACT	A system and method for producing discretely assembled logic blocks where the logic block assemblies are a 3-dimensional representation of the normal digital design hierarchy. The blocks contain embedded logical functions that are built up from only a few basic 2-dimensional parts that are assembled into a 3-dimensional structure that realizes a particular logic or computing element. These structures can be combined to produce more complex digital structures and even processors. The two basic structural parts are a node and a strut with the strut typically including an embedded logic function. These are combined to produce spatially distributed structures.
FILED	Monday, October 15, 2018
APPL NO	16/159835
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Pulse Technique H03K 3/037 (20130101) H03K 19/20 (20130101) H03K 19/21 (20130101) Original (OR) Class
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10498569 — Systems and methods for backscatter communication

US 10498569	Ganesan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Deepak Ganesan (Amherst, Massachusetts); Pengyu Zhang (Palo Alto, California)
ABSTRACT	Systems and methods for wireless communication are provided. The systems and methods employ a backscatter tag that is configured to shift an incident carrier signal received by the tag to a different frequency band and then transmitting the frequency-shifted carrier signal to a receiver. The frequency band to which the carrier signal is shifted is a band in which interference is minimal or non-existent. Further, the backscatter tag is able to operate in an ultra-low power manner, thereby allowing the tag to be incorporated into components like on-body sensors so that the tag can embed additional information into the carrier signal for transmission and processing by the receiver. Exemplary electronic circuits and systems that utilize a frequency-shifted Backscatter, as well as methods for implementing a frequency-shifted Backscatter, are also provided.
FILED	Friday, June 23, 2017
APPL NO	15/631142
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 1/0475 (20130101) H04B 17/318 (20150115) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/04 (20130101) Original (OR) Class
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Department of Agriculture (USDA)

10494489 — Low temperature and efficient fractionation of lignocellulosic biomass using recyclable organic solid acids

US 10494489	Zhu et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S)	Junyong Zhu (Madison, Wisconsin); Liheng Chen (Madison, Wisconsin); Roland Gleisner (Jefferson, Wisconsin)
ABSTRACT	Methods of fractionating lignocellulosic biomass using hydrotropic solid organic acids are provided. Also provided are methods of forming lignin particles, furans, sugars, and/or lignocellulosic micro- and nanofibrils from the liquid and solid fractions produced by fractionation process. The fractionation can be carried out at low temperatures with short reaction times.
FILED	Monday, March 18, 2019
APPL NO	16/356327
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Heterocyclic Compounds C07D 307/36 (20130101) Derivatives of Natural Macromolecular Compounds C08H 8/00 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/00 (20130101) Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor D21C 3/003 (20130101)
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10494683 — Nitrate- and nitrite-reducing probiotic feed additive

US 10494683	Anderson et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); The Texas A and M University System (College Station, Texas)
ASSIGNEE(S)	The Secretary of Agriculture (Washington, District of Columbia); The Texas A and M University System (Bryan, Texas)
INVENTOR(S)	Robin C. Anderson (College Station, Texas); Elizabeth A. Latham (Bryan, Texas); William E. Pinchak (Vernon, Texas)
ABSTRACT	The present invention concerns novel probiotic compositions that increase nitrate- and nitrite-reduction in animals such as ruminants. The present invention thus provides compositions and methods for reducing nitrate/nitrite toxicity in such animals, or prophylactically protecting such animals from the effects of toxicity, such as methemoglobinemia. A novel strain of an unspeciated bacterial strain related to Paenibacillus species with nitrate- and nitrite-reducing capabilities is described. In conjunction with nitrate-supplemented diets, the probiotics of the present invention can also be utilized to reduce methanogenesis in livestock. Furthermore, the probiotic compositions of the present invention can be used to reduce the number and kind of food-borne pathogens, such as Escherichia coli and Campylobacter jejuni.
FILED	Thursday, August 11, 2016
APPL NO	15/234560
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Fodder A23K 10/18 (20160501) A23K 10/40 (20160501) A23K 50/10 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 35/742 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 1/01 (20130101) Original (OR) Class
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Non-Profit Organization (NPO)

10494328 — Amination and hydroxylation of arylmetal compounds

US 10494328	Gao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) Non-Profit Organization (NPO) Robert A. Welch Foundation National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	WILLIAM MARSH RICE UNIVERSITY (Houston, Texas)
ASSIGNEE(S)	William Marsh Rice University (Houston, Texas)
INVENTOR(S)	Hongyin Gao (Houston, Texas); Zhe Zhou (Houston, Texas); Laszlo Kurti (Bellaire, Texas)
ABSTRACT	In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.
FILED	Tuesday, July 25, 2017
APPL NO	15/659320
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	General Methods of Organic Chemistry; Apparatus Therefor C07B 41/02 (20130101) C07B 43/04 (20130101) Acyclic or Carbocyclic Compounds C07C 37/01 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/055 (20130101) C07C 37/64 (20130101) C07C 37/64 (20130101) C07C 39/12 (20130101) C07C 39/14 (20130101) C07C 39/15 (20130101) C07C 39/20 (20130101) C07C 39/205 (20130101) C07C 39/235 (20130101) C07C 41/26 (20130101) C07C 41/26 (20130101) C07C 43/23 (20130101) C07C 209/66 (20130101) Original (OR) Class C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 209/66 (20130101) C07C 211/44 (20130101) C07C 211/47 (20130101) C07C 211/51 (20130101) C07C 211/58 (20130101) C07C 211/59 (20130101) C07C 211/61 (20130101) C07C 213/02 (20130101) C07C 213/02 (20130101) C07C 213/02 (20130101) C07C 213/02 (20130101) C07C 217/80 (20130101) C07C 217/94 (20130101) C07C 219/34 (20130101) C07C 227/06 (20130101) C07C 227/06 (20130101) C07C 227/06 (20130101) C07C 229/56 (20130101) C07C 229/60 (20130101) C07C 303/30 (20130101) C07C 303/30 (20130101) C07C 309/30 (20130101) C07C 319/20 (20130101) C07C 319/20 (20130101) C07C 323/36 (20130101) C07C 2601/02 (20170501) C07C 2601/04 (20170501) C07C 2601/14 (20170501) C07C 2603/18 (20170501) C07C 2603/26 (20170501) Heterocyclic Compounds C07D 209/04 (20130101) C07D 209/88 (20130101) C07D 213/04 (20130101) C07D 213/73 (20130101) C07D 215/38 (20130101) C07D 277/82 (20130101) C07D 295/096 (20130101) C07D 295/135 (20130101) C07D 307/79 (20130101) C07D 307/91 (20130101) C07D 309/12 (20130101) C07D 311/58 (20130101) C07D 317/20 (20130101) C07D 317/28 (20130101) C07D 317/46 (20130101) C07D 317/64 (20130101) C07D 317/66 (20130101) C07D 333/16 (20130101) C07D 333/20 (20130101) C07D 333/36 (20130101) Steroids C07J 41/0011 (20130101)
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10494422 — CCR5 disruption of cells expressing anti-HIV chimeric antigen receptor (CAR) derived from broadly neutralizing antibodies

US 10494422	Wagner et al.
FUNDED BY	Non-Profit Organization (NPO) Bill and Melinda Gates Foundation (BMGF)
APPLICANT(S)	Seattle Children's Hospital (Seattle, Washington)
ASSIGNEE(S)	Seattle Children's Hospital (Seattle, Washington)
INVENTOR(S)	Thor Wagner (Seattle, Washington); Andrew M. Scharenberg (Seattle, Washington); David J. Rawlings (Seattle, Washington); Blythe Sather (Normandy Park, Washington); Jaya Sahni (Seattle, Washington)
ABSTRACT	The present application generally relates to methods of genetically modifying a T-cell comprising a chimeric antigen receptor wherein the T-cell lacks a co-receptor for HIV. The application further relates to methods of making a nucleic acid encoding a chimeric antigen receptor, nucleic acids encoding a chimeric antigen receptor, and genetically modified T-cells comprising a chimeric antigen receptor disclosed herein. The application further relates to methods of treating, inhibiting, or ameliorating HIV in a subject including administering to the subject a cell disclosed herein.
FILED	Wednesday, April 08, 2015
APPL NO	15/306643
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 14/7051 (20130101) C07K 14/7158 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/1054 (20130101) Original (OR) Class C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) C07K 2319/81 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 2510/00 (20130101)
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Small Business Administration (SBA)

10493072 — Lanthionine synthetase C-like 2-based therapeutics

US 10493072	Bassaganya-Riera et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Small Business Administration (SBA) Small Business Innovation Research (SBIR) Small Business Technology Transfer (STTR)
APPLICANT(S)	Landos Biopharma, Inc. (Blacksburg, Virginia)
ASSIGNEE(S)	LANDOS BIOPHARMA, INC. (Blacksburg, Virginia)
INVENTOR(S)	Josep Bassaganya-Riera (Blacksburg, Virginia); Adria Carbo Barrios (Blacksburg, Virginia); Richard Gandour (Blacksburg, Virginia); Julian D. Cooper (Blacksburg, Virginia); Raquel Hontecillas (Blacksburg, Virginia)
ABSTRACT	Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease.
FILED	Thursday, December 20, 2018
APPL NO	16/227940
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/423 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4439 (20130101) Acyclic or Carbocyclic Compounds C07C 65/40 (20130101) Heterocyclic Compounds C07D 213/69 (20130101) C07D 213/79 (20130101) C07D 307/60 (20130101) C07D 307/68 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101)
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10493509 — Spiral forming

US 10493509	Smith et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Keystone Tower Systems, Inc. (Westminster, Colorado)
ASSIGNEE(S)	Keystone Tower Systems, Inc. (Westminster, Colorado)
INVENTOR(S)	Eric D. Smith (Denver, Colorado); Rosalind K. Takata (Denver, Colorado); Daniel Ainge (Boulder, Colorado); Loren Daniel Bridgers (Golden, Colorado)
ABSTRACT	Spiral forming methods can be used to join edges of a rolled material along a spiral joint to form conical and/or cylindrical structures. Alignment of the edges of the rolled material can be controlled in a wrapping direction as the material is being joined along the spiral joint to form the structure. By controlling alignment of the edges of the material as the edges of the material are being joined, small corrections can be made over the course of forming the structure facilitating control over geometric tolerances of the resulting spiral formed structure.
FILED	Friday, June 24, 2016
APPL NO	15/191841
ART UNIT	3725 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/12 (20130101) B21C 37/122 (20130101) B21C 37/124 (20130101) B21C 37/128 (20130101) Original (OR) Class B21C 37/185 (20130101) Wind Motors F03D 13/20 (20160501) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/912 (20130101)
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Department of Commerce (DOC)

10494531 — Flame retardant coatings

US 10494531	Zammarano et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	Mauro Zammarano (Gaithersburg, Maryland); Douglas Fox (Reston, Virginia); Philipp Grützmacher (Rathsberg, Germany); Rick Davis (Ijamsville, Maryland)
ASSIGNEE(S)	AMERICAN UNIVERSITY (Washington, District of Columbia)
INVENTOR(S)	Mauro Zammarano (Gaithersburg, Maryland); Douglas Fox (Reston, Virginia); Philipp Grützmacher (Rathsberg, Germany); Rick Davis (Ijamsville, Maryland)
ABSTRACT	A flame retardant coating composition comprising poly(dopamine) and either tris(hydroxymethyl)aminomethane) or gaseous ammonia, as well as an article comprising a substrate and the flame retardant coating composition, is provided. In various embodiments, the poly(dopamine) is substantially water insoluble. The coating composition can further comprise at least one additional component selected from the group consisting of melamine, an anionic clay, a phosphorus-containing compound, an amine-containing compound, aluminosilicates, silicon oxides, and combinations thereof. Also provided are methods for forming the flame retardant coating composition and methods for increasing flame retardant properties of a substrate.
FILED	Tuesday, May 23, 2017
APPL NO	15/602340
ART UNIT	1768 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 2261/334 (20130101) C08G 2261/344 (20130101) C08G 2261/592 (20130101) C08G 2261/3241 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/28 (20130101) C08K 3/28 (20130101) C08K 5/17 (20130101) C08K 5/17 (20130101) C08K 5/52 (20130101) Compositions of Macromolecular Compounds C08L 65/00 (20130101) C08L 65/00 (20130101) C08L 65/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/18 (20130101) Original (OR) Class C09D 165/00 (20130101)
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Department of Veterans Affairs (DVA)

10493141 — Viral RNA segments as immunomodulatory agents and vaccine components

US 10493141	Stapleton et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
ASSIGNEE(S)	THE UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
INVENTOR(S)	Jack T. Stapleton (Iowa City, Iowa); Nirjal Bhattarai (Coralville, Iowa); James McLinden (Coralville, Iowa); Jinhau Xiang (Iowa City, Iowa); Bev Davidson (Philadelphia, Pennsylvania)
ABSTRACT	The disclosure provides compositions and methods involving viral RNA segments for use in modulating immune responses, including inhibition inflammation related to pathogenic T-cell activation. In addition, modification of the viral sequences responsible for modulating immune response provides for improved vaccine formulations.
FILED	Wednesday, September 09, 2015
APPL NO	15/510315
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Peptides C07K 14/08 (20130101) C07K 14/473 (20130101) C07K 14/1833 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/04 (20130101) C12N 15/117 (20130101) C12N 2310/17 (20130101) C12N 2330/50 (20130101) C12N 2760/18711 (20130101) C12N 2770/24111 (20130101) C12N 2770/24211 (20130101)
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Department of the Treasury (TREASURY)

10494672 — Systems and methods for genetic and biological analysis

US 10494672	Esfandyarpour et al.
FUNDED BY	Department of Health and Human Services (HHS) Department of the Treasury (TREASURY) Internal Revenue Service (IRS)
APPLICANT(S)	GenapSys, Inc. (Redwood City, California)
ASSIGNEE(S)	GENAPSYS, INC. (Redwood City, California)
INVENTOR(S)	Hesaam Esfandyarpour (Redwood City, California); Kosar Baghbani Parizi (Redwood City, California); Mark F. Oldham (Emerald Hills, California); Eric S. Nordman (Palo Alto, California); Richard T. Reel (Hayward, California); Susanne Baumhueter (Redwood City, California); Cheryl Heiner (La Honda, California); Frank Lee (Irvine, California)
ABSTRACT	The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.
FILED	Friday, February 22, 2019
APPL NO	16/283544
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 1/6874 (20130101) C12Q 2527/119 (20130101) C12Q 2527/119 (20130101) C12Q 2549/126 (20130101) C12Q 2563/116 (20130101) C12Q 2563/116 (20130101) C12Q 2565/607 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) G01N 33/5438 (20130101) G01N 33/54313 (20130101)
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National Aeronautics and Space Administration (NASA)

10495609 — Ultrasonic inspection technique to assess bond quality in composite structures

US 10495609	Kim et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC)
APPLICANT(S)	The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Yong Min Kim (Torrance, California); Joseph T Case (Hawthorne, California); Shant Kenderian (Pasadena, California)
ABSTRACT	An ultrasonic inspection technique may be used to inspect quality of a bond between thermal protection system (TPS) material and a composite. The technique may include a highly damped transducer emitting an incident wave, which may traverse through thermal protection system (TPS) material and to a back wall of a composite. The incident wave may be of a low frequency signal, and may return a bondline echo and a backwall echo. The bondline echo is returned when the incident wave reaches a bondline and the backwall echo is returned when the incident wave reaches the backwall of the composite. The bondline echo and the backwall echo may be used to generate a waveform to assess the bond quality, revealing possible unbonds or kissing unbonds.
FILED	Tuesday, October 18, 2016
APPL NO	15/296958
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/07 (20130101) G01N 29/11 (20130101) G01N 29/043 (20130101) G01N 29/48 (20130101) G01N 29/069 (20130101) Original (OR) Class G01N 29/4454 (20130101) G01N 2291/012 (20130101) G01N 2291/015 (20130101) G01N 2291/044 (20130101) G01N 2291/0231 (20130101) G01N 2291/267 (20130101) G01N 2291/0289 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Security Agency (NSA)

10496574 — Processors, methods, and systems for a memory fence in a configurable spatial accelerator

US 10496574	Fleming et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)	Intel Corporation (Santa Clara, California)
INVENTOR(S)	Kermin Fleming (Hudson, Massachusetts); Kent D. Glossop (Merrimack, New Hampshire); Simon C. Steely, Jr. (Hudson, New Hampshire)
ABSTRACT	Systems, methods, and apparatuses relating to a memory fence mechanism in a configurable spatial accelerator are described. In one embodiment, a processor includes a plurality of processing elements and an interconnect network between the plurality of processing elements to receive an input of a dataflow graph comprising a plurality of nodes, wherein the dataflow graph is to be overlaid into the interconnect network and the plurality of processing elements with each node represented as a dataflow operator in the plurality of processing elements, and the plurality of processing elements are to perform a plurality of operations, each by a respective, incoming operand set arriving at each of the dataflow operators of the plurality of processing elements. The processor also includes a fence manager to manage a memory fence between a first operation and a second operation of the plurality of operations.
FILED	Thursday, September 28, 2017
APPL NO	15/719285
ART UNIT	2184 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 12/0811 (20130101) G06F 12/0813 (20130101) G06F 13/28 (20130101) Original (OR) Class G06F 2212/283 (20130101) G06F 2212/621 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

United States Postal Service (USPS)

10498720 — System and method of providing identity verification services

US 10498720	Moran et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	Timothy M. Moran (National Harbor, Maryland); Jane E. Quenk (Washington, District of Columbia); Douglas Paul Glair (Baltimore, Maryland); Charles P. McLellan (Washington, District of Columbia)
ABSTRACT	A system and method of validating an upgrade of authentication credentials includes authenticating a first user being associated with a first entity, receiving input identifying a customer name for the online account, receiving input indicating a type of identification to be presented at the validation event, receiving input indicating a transaction code associated with the validation event, and receiving input indicating a location of the validation event, and further includes authenticating a second user being associated with a second entity, providing to the second user a list of validation events for a location, receiving input selecting a validation event in the list of validation events, presenting one or more of the customer name, transaction code, and type of identification associated with the selected validation event, and receiving input indicating a result of the validation event, where a credential or token is created and assigned based on the validation event.
FILED	Monday, April 29, 2019
APPL NO	16/397901
ART UNIT	2497 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/31 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) G06Q 20/20 (20130101) G06Q 20/34 (20130101) G06Q 20/40 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/08 (20130101) Original (OR) Class H04L 63/083 (20130101) H04L 63/126 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10493144 — Recombinant adenovirus vectored FMDV vaccines and uses thereof

US 10493144	Widener et al.
FUNDED BY
APPLICANT(S)	Boehringer Ingelheim Animal Health USA Inc. (Duluth, Georgia); GENVEC INC. (Gaithersburg, Maryland); THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary (Greenport, New York)
ASSIGNEE(S)	BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC. (Duluth, Georgia)
INVENTOR(S)	Justin Widener (Athens, Georgia); Leszlie Woodyard (Hull, Georgia); Leonardo Siger (Watkinsville, Georgia); Douglas Brough (Gaithersburg, Maryland); Damodar Ettyreddy (Clarksburg, Maryland); Jason Gall (Germantown, Maryland); Duncan McVey (Derwood, Maryland); Tom Burrage (Guilford, Connecticut); Lauri Motes-Kreimeyer (Athens, Georgia); Marc Fiorucci (Suwanee, Georgia)
ABSTRACT	The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
FILED	Thursday, January 17, 2019
APPL NO	16/250654
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/552 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2710/10034 (20130101) C12N 2770/32134 (20130101) C12N 2800/107 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10497440 — Crossbar arrays for calculating matrix multiplication

US 10497440	Hu et al.
FUNDED BY
APPLICANT(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
ASSIGNEE(S)	HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas)
INVENTOR(S)	Miao Hu (Palo Alto, California); John Paul Strachan (San Carlos, California); Zhiyong Li (Foster City, California); R. Stanley Williams (Portola Valley, California)
ABSTRACT	A crossbar array, comprises a plurality of row lines, a plurality of column lines intersecting the plurality of row lines at a plurality of intersections, and a plurality of junctions coupled between the plurality of row lines and the plurality of column lines at a portion of the plurality of intersections. Each junction comprises a resistive memory element, and the junctions are positioned to calculate a matrix multiplication of a first matrix and a second matrix.
FILED	Friday, August 07, 2015
APPL NO	15/570932
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Electric Digital Data Processing G06F 17/16 (20130101) Analogue Computers G06G 7/16 (20130101) Image Data Processing or Generation, in General G06T 1/20 (20130101) Static Stores G11C 13/0002 (20130101) G11C 13/004 (20130101) G11C 13/0007 (20130101) G11C 13/0069 (20130101) Original (OR) Class G11C 2213/32 (20130101) G11C 2213/34 (20130101) G11C 2213/72 (20130101) G11C 2213/77 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/2463 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, December 03, 2019.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20191203.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

info@wayfinder.digital