FedInvent™ Patents

Patent Details for Tuesday, June 09, 2020

This page was updated on Monday, March 27, 2023 at 06:06 AM GMT

Department of Health and Human Services (HHS)

10674901 — Minimally-invasive measurement of esophageal inflammation

US 10674901	Furuta et al.
FUNDED BY	Department of Health and Human Services (HHS) Food and Drug Administration (FDA) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado); The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Glenn T. Furuta (Aurora, Colorado); Steven J. Ackerman (Naperville, Illinois)
ABSTRACT	The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation.
FILED	Friday, April 27, 2018
APPL NO	15/964839
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/00156 (20130101) A61B 1/2733 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/4375 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/527 (20130101) C12Q 1/6883 (20130101) Enzymes C12Y 406/01002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) G01N 33/6863 (20130101) G01N 33/6866 (20130101) G01N 33/6869 (20130101) G01N 33/6893 (20130101) G01N 2333/521 (20130101) G01N 2333/988 (20130101) G01N 2800/14 (20130101) G01N 2800/7028 (20130101) G01N 2800/7095 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Technologies for Adaptation to Climate Change Y02A 90/26 (20180101)
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10674918 — Near-infrared (NIR) optical scanner

US 10674918	Godavarty et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida)
ASSIGNEE(S)	THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida)
INVENTOR(S)	Anuradha Godavarty (Miami, Florida); Youngjin Jung (Miami, Florida); Jean Gonzalez (Miami, Florida)
ABSTRACT	A method, apparatus, and system acquire data to create a 3D mesh representing a 3D object. The method, apparatus, and system acquire image data of the 3D object using an imaging probe that includes illumination and detection capability. A light source operates to illuminate the 3D object for reflection and/or trans-illumination imaging, and a detection assembly receives image reflection and/or trans-illumination image data. The reflectance and trans-illumination image data collected by the detection assembly are co-registered with a previously acquired 3D mesh using data from a tracking system monitoring the position of the probe, displayed in real-time, and optionally saved.
FILED	Monday, January 07, 2013
APPL NO	14/370600
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Original (OR) Class A61B 5/0073 (20130101) A61B 5/0091 (20130101) A61B 5/4312 (20130101) A61B 2560/0431 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/49 (20130101) G01N 21/359 (20130101) G01N 21/6456 (20130101) G01N 2021/5957 (20130101)
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10674930 — Single-unit leadless EEG sensor

US 10674930	Sun et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Mingui Sun (Pittsburgh, Pennsylvania); Bo Luan (Pittsburgh, Pennsylvania); Parthasarathy Deenadayalan Thirumala (Glenshaw, Pennsylvania); Wenyan Jia (Wexford, Pennsylvania); Di Gao (Sewickley, Pennsylvania); Jeffrey Balzer (Wexford, Pennsylvania)
ABSTRACT	Single-unit EEG sensors contain multiple closely spaced dry electrodes that can hook onto skin and associated electronic circuitry such as amplifiers, A/D convertors, wireless transmitters, and a power source such as a battery. The electrodes can be separated by about 20 mm or less, and the associated circuitry can be situated within a volume defined by the multiple electrodes. The single-unit sensors hook onto the skin using a tooth surface so that a rotation of the sensor secures and electrically connects the sensor to the skin.
FILED	Friday, September 30, 2016
APPL NO	15/282828
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0006 (20130101) A61B 5/0478 (20130101) Original (OR) Class A61B 5/6839 (20130101) A61B 5/7225 (20130101) A61B 2562/125 (20130101)
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10675008 — Steerable biopsy needle

US 10675008	Ryu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Seok Chang Ryu (Stanford, California); Mark Cutkosky (Palo Alto, California); Richard J. Black (Menlo Park, California); Joannes Mario Costa (Rancho La Costa, California); Behzad Moslehi (Los Altos, California); Fereydoun Faridian (Atherton, California); Levy Oblea (Union City, California); Vahid Sotoudeh (Los Altos, California)
ASSIGNEE(S)	Intelligent Fiber Optic Systems, Inc. (San Jose, California)
INVENTOR(S)	Seok Chang Ryu (Stanford, California); Mark Cutkosky (Palo Alto, California); Richard J. Black (Menlo Park, California); Joannes Mario Costa (Rancho La Costa, California); Behzad Moslehi (Los Altos, California); Fereydoun Faridian (Atherton, California); Levy Oblea (Union City, California); Vahid Sotoudeh (Los Altos, California)
ABSTRACT	A biopsy needle has a cylindrical shell outer cannula and a stylet consisting of an inner stylet and outer stylet, both of which are inserted into the cylindrical cannula. The outer stylet has a series of strain relieved slits which provide bending over a deflection region in one direction, and the outer stylet is formed from a material such as a shape memory alloy (SMA) having a superelastic phase. The deflection is generated by an SMA wire spanning a deflection extent and attached to the outer stylet on either side of the deflection extent. The inner stylet, when positioned inside the outer stylet, has one or more actuation fibers which couple optical energy into the SMA wire, causing a deflection of the outer stylet over the deflection extent, with the optical energy provided to the actuation fibers for control of the deflection.
FILED	Tuesday, September 24, 2013
APPL NO	14/034767
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 10/04 (20130101) A61B 10/0275 (20130101) Original (OR) Class A61B 17/3421 (20130101) A61B 2010/045 (20130101) A61B 2017/003 (20130101)
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10675138 — Scaffolds for soft tissue and uses thereof

US 10675138	Schwartz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE) Division of Materials Research (DMR)
APPLICANT(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
INVENTOR(S)	Jeffrey Schwartz (Princeton, New Jersey); Jean E. Schwarzbauer (Princeton, New Jersey); Casey M. Jones (Portland, Oregon); Patrick E. Donnelly (Lawrenceville, New Jersey); Stephen B. Bandini (Newton, Massachusetts); Shivani Singh (El Cerrito, California)
ABSTRACT	The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair and transplantation.
FILED	Monday, October 05, 2015
APPL NO	14/875168
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/0077 (20130101) Original (OR) Class A61F 2/30771 (20130101) A61F 2002/0081 (20130101) A61F 2002/0086 (20130101) A61F 2002/3084 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/02 (20130101) A61L 27/06 (20130101) A61L 27/10 (20130101) A61L 27/16 (20130101) A61L 27/24 (20130101) A61L 27/047 (20130101) A61L 27/227 (20130101) A61L 27/306 (20130101) A61L 27/383 (20130101) A61L 27/3633 (20130101) A61L 27/3834 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 2533/10 (20130101) C12N 2533/12 (20130101) C12N 2533/30 (20130101) C12N 2533/90 (20130101) C12N 2535/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/405 (20130101)
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10675253 — Methods of diagnosis and treatment involving nitrite

US 10675253	Kevil et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana)
ASSIGNEE(S)	BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY (Baton Rouge, Louisiana)
INVENTOR(S)	Christopher Kevil (Shreveport, Louisiana); Sibile Pardue (Shreveport, Louisiana)
ABSTRACT	Methods and therapeutics for treating nitric oxide (NO) mediated condition comprising administering a therapeutically effective amount of a pharmaceutical composition containing a therapeutic, wherein the therapeutic one of increases xanthine oxidase (XO) associated nitrite conversion to nitric oxide and increases nitrite conversion to nitric oxide via DADS. Method and devices for measuring an amount of nitrite in a sample comprising obtaining a sample, adding diallyl disulfide (DADS) to the sample, measuring a post DADS amount of nitric oxide (NO) in the sample, and using the post DADS amount of NO in the sample to determine the amount of nitrite in the sample. Methods and therapeutics for diagnosing and treating critical limb ischemia (CLI) versus non-critical limb ischemic peripheral artery disease (PAD) in a patient comprising determining a patient indicator value, where the patient indicator is value one of a total hydrogen sulfide metabolite plasma level, a total nitric oxide, nitrite, and nitrite (NOx) plasma level, a ratio of free hydrogen sulfide plasma level to total NOx plasma level, and a ratio of total hydrogen sulfide metabolite plasma level and total NOx plasma level, diagnosing the patient with as having CLI based on the patient indicator value, and administering to the patient a therapeutic for CLI.
FILED	Monday, March 26, 2018
APPL NO	15/935581
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/105 (20130101) Original (OR) Class A61K 33/00 (20130101) A61K 38/44 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Enzymes C12Y 117/03002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/84 (20130101) G01N 2800/32 (20130101)
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10675267 — Methods for detection and eradication of myeloid leukemia stem cells

US 10675267	Jamieson et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Regents Of The University Of California (San Francisco, California)
ASSIGNEE(S)	The Regents Of The University Of California (Oakland, California)
INVENTOR(S)	Catriona H.m. Jamieson (La Jolla, California); Leslie C. Robertson (La Jolla, California); Larisa Balaian (San Diego, California); James J. La Clair (San Diego, California); Reymundo Villa (San Mateo, California); Heather Leu (Walnut, California); Nathaniel Delos Santos (San Diego, California); Michael D. Burkart (La Jolla, California)
ABSTRACT	There are provided, inter alia, methods and compositions for diagnosis and treatment of acute myeloid leukemia (AML), secondary acute myeloid leukemia (sAML), and age-related diseases.
FILED	Friday, September 23, 2016
APPL NO	15/761983
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0695 (20130101) C12N 2501/999 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2333/912 (20130101) G01N 2333/70585 (20130101)
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10675273 — Benzothiazole amphiphiles

US 10675273	Yang
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Jerry Yang (La Jolla, California)
ABSTRACT	Disclosed herein, inter alia, are compounds and methods for increasing spine density in a neuron, and for treatment of neuronal diseases and cancer.
FILED	Wednesday, January 04, 2017
APPL NO	16/066285
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) Original (OR) Class A61K 47/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 277/66 (20130101)
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10675285 — Inhibitors of hemeprotein-catalyzed lipid peroxidation

US 10675285	Oates et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	John A. Oates (Nashville, Tennessee); L. Jackson Roberts (Gallatin, Tennessee); Ned A. Porter (Franklin, Tennessee); Olivier Boutaud (Nashville, Tennessee)
ABSTRACT	Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
FILED	Tuesday, September 15, 2015
APPL NO	14/855314
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/44 (20130101) A61K 31/436 (20130101) A61K 31/505 (20130101) A61K 31/519 (20130101) A61K 31/4375 (20130101) A61K 31/5365 (20130101) Original (OR) Class Heterocyclic Compounds C07D 213/74 (20130101) C07D 239/42 (20130101) C07D 471/04 (20130101) C07D 498/04 (20130101)
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10675289 — Methods of treating pancreatic cancer

US 10675289	Njar et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Maryland, Baltimore (Baltimore, Maryland)
ASSIGNEE(S)	University of Maryland, Baltimore (Baltimore, Maryland)
INVENTOR(S)	Vincent C. O. Njar (Glen Burnie, Maryland); Puranik Purushottamachar (Gaithersburg, Maryland); Andrew K. Kwegyir-Afful (Severn, Maryland)
ABSTRACT	Described herein are methods and compositions for the treatment of pancreatic cancer in a subject in need thereof. The pancreatic cancer may be resistant to other therapeutic regimens. The methods may comprise administering ARDA compounds to the subject.
FILED	Friday, October 02, 2015
APPL NO	15/516113
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) Original (OR) Class A61K 31/58 (20130101) A61K 31/7068 (20130101) A61K 31/7068 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Steroids C07J 43/003 (20130101)
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10675293 — Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes

US 10675293	Cohen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California); National Yang-Ming University (Taipei, Taiwan)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California); National Yang-Ming University (Taipei, Taiwan)
INVENTOR(S)	Stanley N. Cohen (Stanford, California); Ning Deng (Palo Alto, California); Yanan Feng (San Jose, California); Tzu-Hao Cheng (Taipei, Taiwan); Yun-Yun Wu (Taipei, Taiwan); Wen-Chieh Hsieh (Taipei, Taiwan)
ABSTRACT	Aspects of the invention include methods of reducing the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by contacting the cell with an effective amount of a nucleoside agent, as well as compositions used in such methods. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced in a variety of different ways, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided.
FILED	Wednesday, May 18, 2016
APPL NO	15/554679
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7064 (20130101) A61K 31/7076 (20130101) Original (OR) Class A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101)
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10675301 — Chitosan oligomer and zinc oxide nanoparticle compositions for treating drug resistant bacteria and biofilm

US 10675301	Mohapatra et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of South Florida (Tampa, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida)
INVENTOR(S)	Shyam S. Mohapatra (Lutz, Florida); Alya Limayem (Tampa, Florida)
ABSTRACT	A broad-based remediation mechanism against MRFs and alternative fecal indicators such as multidrug resistant Pseudomonas aeruginosa, including nanotechnology formulations and methodologies that may be used to develop novel mitigation strategies against certain drug resistant bacterial strains. The current invention relates to mitigation of drug resistant bacteria, for example in hospitals and in food animals, and to the identification. The invention uses hybrid nanomaterials comprising oligo-chitosan and zinc oxide formulated as nanoparticles and micelles. The invention also relates to the treatment of multi-drug resistant biofilms which mimic in vivo conditions. The inventors unexpectedly found unique properties of very small oligomers of chitosan that effectively mitigate MRF and alternative resistant strain-induced illnesses without compromising the balance of the beneficial flora in the physiological and ecological microenvironments. The combination of chitosan with zinc oxide demonstrated synergistic and unexpected effects in treating multi-drug resistant pathogens.
FILED	Monday, January 14, 2019
APPL NO	16/247061
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/51 (20130101) A61K 9/1075 (20130101) A61K 9/5161 (20130101) A61K 31/722 (20130101) A61K 31/722 (20130101) A61K 33/30 (20130101) Original (OR) Class A61K 33/30 (20130101) A61K 47/6907 (20170801) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101)
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10675310 — Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders

US 10675310	Bailey et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Antoinette Bailey (Pasadena, California); Sarkis K. Mazmanian (Porter Ranch, California); Paul H. Patterson (Altadena, California)
ABSTRACT	Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The subject in need thereof can have a gut microbiota signature characteristic of an adult. The bacterial species can include Bacteroides (e.g., B. fragilis, B. thetaiomtaomicron, and/or B. vulgatus), and/or Enterococcus (e.g., E. faecalis, E. faecium, E. hirae, E. avium, E. durans, E. gallinarum, or E. casseliflavus). Upon treatment, one or more ASD-related behaviors can be improved in the subject.
FILED	Monday, September 24, 2018
APPL NO	16/140013
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 35/741 (20130101) Original (OR) Class
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10675315 — Botanical extracts and compounds from schinus plants and methods of use

US 10675315	Quave et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH)
APPLICANT(S)	Emory University (Atlanta, Georgia)
ASSIGNEE(S)	Emory University (Atlanta, Georgia)
INVENTOR(S)	Cassandra L. Quave (Lilburn, Georgia); James Lyles (Decatur, Georgia)
ABSTRACT	This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.
FILED	Friday, July 08, 2016
APPL NO	15/205493
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 8/9789 (20170801) A61K 36/22 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2236/33 (20130101) A61K 2236/39 (20130101) A61K 2236/55 (20130101) A61K 2236/331 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/40 (20130101) A61L 15/44 (20130101) A61L 2300/30 (20130101) A61L 2300/406 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/10 (20180101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/005 (20130101) A61Q 19/10 (20130101) Detergent Compositions; Use of Single Substances as Detergents; Soap or Soap-making; Resin Soaps; Recovery of Glycerol C11D 3/382 (20130101) C11D 9/04 (20130101) C11D 9/38 (20130101)
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10675321 — Botanical extracts and compounds from Castanea plants and methods of use

US 10675321	Quave et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH)
APPLICANT(S)	Emory University (Atlanta, Georgia); University of Iowa Research Foundation (Iowa City, Iowa)
ASSIGNEE(S)	Emory University (Atlanta, Georgia); University of Iowa Research Foundation (Iowa City, Iowa)
INVENTOR(S)	Cassandra L. Quave (Decatur, Georgia); James Lyles (Decatur, Georgia); Alexander R. Horswill (Iowa City, Iowa)
ABSTRACT	This disclosure relates to extracts from chestnut plants and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the leaves of a Castanea plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.
FILED	Wednesday, December 19, 2018
APPL NO	16/225281
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 8/97 (20130101) A61K 8/9789 (20170801) A61K 9/0014 (20130101) A61K 9/0036 (20130101) A61K 36/49 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2236/15 (20130101) A61K 2236/17 (20130101) A61K 2236/39 (20130101) A61K 2236/55 (20130101) A61K 2800/10 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/40 (20130101) A61L 15/44 (20130101) A61L 15/46 (20130101) A61L 15/58 (20130101) A61L 2300/404 (20130101) A61L 2300/406 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/00 (20130101) A61Q 19/10 (20130101) Detergent Compositions; Use of Single Substances as Detergents; Soap or Soap-making; Resin Soaps; Recovery of Glycerol C11D 3/48 (20130101) C11D 3/382 (20130101) C11D 3/2075 (20130101)
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10675329 — Composition comprising connective tissue growth factor (CTGF) for cardiac tissue repair

US 10675329	Spees
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Vermont and State Agriculture College (Burlington, Vermont)
ASSIGNEE(S)	University of Vermont and State Agriculture College (Burlington, Vermont)
INVENTOR(S)	Jeffrey Spees (Burlington, Vermont)
ABSTRACT	The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
FILED	Wednesday, June 14, 2017
APPL NO	15/623025
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) A61K 38/18 (20130101) Original (OR) Class A61K 38/18 (20130101) A61K 38/28 (20130101) A61K 38/28 (20130101) A61K 38/30 (20130101) A61K 38/30 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 14/62 (20130101) C07K 14/65 (20130101) C07K 14/475 (20130101)
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10675331 — Method for achieving desired glial growth factor 2 plasma levels

US 10675331	Kim et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Acorda Therapeutics, Inc. (Ardsley, New York)
ASSIGNEE(S)	Acorda Therapeutics, Inc. (Ardsley, New York)
INVENTOR(S)	Haesun Kim (Teaneck, New Jersey); Anthony O. Caggiano (Larchmont, New York)
ABSTRACT	The present invention relates to administering glial growth factor 2 (GGF2) to a patient in need thereof, to achieve serum levels of GGF2 within a desired therapeutic window determined based on the disease or disorder afflicting the patient. In a particular embodiment, the patient is suffering from a disease or disorder associated with reduced levels of myelination and the GGF2 is administered to promote myelination in the patient.
FILED	Tuesday, July 25, 2017
APPL NO	15/658967
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/18 (20130101) A61K 38/18 (20130101) A61K 38/1883 (20130101) Original (OR) Class A61K 38/1883 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6872 (20130101) G01N 33/6896 (20130101) G01N 2333/4756 (20130101) G01N 2800/285 (20130101)
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10675343 — Vaccines and methods for creating a vaccine for inducing immunity to all dengue virus serotypes

US 10675343	Michael et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Scott F. Michael (Estero, Florida); Sharon Isern (Estero, Florida)
ASSIGNEE(S)
INVENTOR(S)	Scott F. Michael (Estero, Florida); Sharon Isern (Estero, Florida)
ABSTRACT	A method to produce a chimeric protein having a flavivirus backbone and portions dengue virus is provided. The flavivirus envelope protein, such as from yellow fever virus 17D vaccine strain, is modified replacing amino acids surrounding the fusion loop of the flavivirus backbone with corresponding amino acids from the dengue virus envelope protein. The chimeric protein is useful as a vaccine to stimulate an immune response against DENV infection, thereby producing broadly neutralizing (protective) antibodies against dengue virus and reduce the induction of non-neutralizing antibodies that will cause enhancement.
FILED	Monday, October 29, 2018
APPL NO	16/174253
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/55505 (20130101) A61K 2039/55527 (20130101) A61K 2039/55538 (20130101) A61K 2039/55555 (20130101)
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10675345 — Recombinant influenza virus vaccines for influenza

US 10675345	Kang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Georgia State University Research Foundation, Inc. (Atlanta, Georgia)
ASSIGNEE(S)	Georgia State University Research Foundation, Inc. (Atlanta, Georgia)
INVENTOR(S)	Sang-Moo Kang (Lilburn, Georgia); Yu-Na Lee (Atlanta, Georgia); Min-Chul Kim (Decatur, Georgia)
ABSTRACT	Disclosed are recombinant chimeric influenza virus vaccines and live attenuated influenza virus (LAIV) vaccines expressing foreign (RSV) neutralizing epitopes or conserved M2e epitopes that are capable of providing broader cross-protection against influenza virus and/or protecting against respiratory syncytial virus (RSV) without vaccine-enhanced RSV disease (ERD).
FILED	Wednesday, December 30, 2015
APPL NO	15/538133
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 39/295 (20130101) A61K 2039/55505 (20130101) Peptides C07K 14/005 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/16134 (20130101) C12N 2760/16143 (20130101) C12N 2760/18534 (20130101)
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10675346 — Antigenic polypeptides comprising pre-hairpin intermediate conformations of HIV-1 GP41

US 10675346	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Bing Chen (Westwood, Massachusetts); Gary H. Frey (Nashua, New Hampshire); Jia Chen (Brookline, Massachusetts)
ASSIGNEE(S)	Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Bing Chen (Westwood, Massachusetts); Gary H. Frey (Nashua, New Hampshire); Jia Chen (Brookline, Massachusetts)
ABSTRACT	Isolated, antigenic polypeptides including a pre-hairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Exemplary pre-hairpin intermediate conformations of gp41 include an oligomerization domain; a heptad repeat 2 motif; and a membrane-proximal external region, where the polypeptide lacks a heptad repeat 1 motif, and where the isolated, antigenic polypeptides elicit production of a broadly neutralizing antibody against HIV when injected into a subject. Antibodies that bind to a pre-hairpin intermediate conformation of gp41 and methods of making antibodies a that bind to pre-hairpin intermediate conformation of gp41 are also provided. Vaccines against a pre-hairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, pre-hairpin intermediate conformation of gp41 are further provided.
FILED	Wednesday, November 09, 2011
APPL NO	13/884823
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/21 (20130101) Original (OR) Class Peptides C07K 14/005 (20130101) C07K 2319/73 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16033 (20130101) C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56988 (20130101) G01N 2333/162 (20130101)
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10675349 — Humanized CC chemokine receptor 4 (CCR4) antibodies and methods of use thereof

US 10675349	Marasco et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S)	Wayne A. Marasco (Wellesley, Massachusetts); Quan Zhu (Needham, Massachusetts); De-Kuan Chang (Boston, Massachusetts)
ABSTRACT	The present invention provides humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to the chemokine receptor CCR4. This antibody is derived from CCR4-IgG1 and recognizes the same epitope. This antibody contains either an IgG4 or a stabilized IgG4 in order to improve binding efficiency and reduce in vivo Fab arm exchange. Binding of the antibodies disclosed herein to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer.
FILED	Tuesday, October 06, 2015
APPL NO	15/517108
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 39/39558 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/18 (20130101) C07K 16/24 (20130101) C07K 16/246 (20130101) C07K 16/2809 (20130101) C07K 16/2866 (20130101) C07K 2317/31 (20130101) C07K 2317/33 (20130101) C07K 2317/35 (20130101) C07K 2317/52 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101)
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10675364 — Rhodol fluorophores for near-infrared imaging

US 10675364	Hettie et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California); THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California); THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri)
INVENTOR(S)	Kenneth Hettie (Stanford, California); Jessica Klockow (Stanford, California); Timothy Glass (Columbia, Missouri); Frederick T. Chin (Standford, California)
ABSTRACT	The present disclosure encompasses embodiments of a novel near-infrared-emitting molecular fluorophore and probes incorporating said fluorophore advantageous for in vitro and in vivo research studies. The fluorophore is robust, photostable, and possesses functionalities for easy bioorthogonal conjugation (e.g., click chemistry, hydrazone formation, Diels Alder, Staudinger ligation, etc.). It is biocompatible and emits at 711 nm in aqueous conditions. These fluorophores may be used to fluorescently tag biological molecules or structures of interest, or used as optical reporters (i.e., activatable molecular probes, fluorescent dyes) for specific biomarkers/analytes as they can be switched from “off” to “on.” This fluorophore is useful for cellular assays and preclinical small animal imaging as the near-infrared emission is highly penetrating, and the photophysical properties are outstanding. As such, the properties of this class of fluorophores could easily be translated for use in clinical applications.
FILED	Thursday, June 23, 2016
APPL NO	15/738327
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0043 (20130101) Original (OR) Class A61K 49/0058 (20130101) Heterocyclic Compounds C07D 491/052 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 2458/00 (20130101)
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10675380 — Nano-textured biocompatible antibacterial film

US 10675380	Burns
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	N2 Biomedical LLC (Bedford, Massachusetts)
ASSIGNEE(S)	N2 BIOMEDICAL LLC (Bedford, Massachusetts)
INVENTOR(S)	Jason E. Burns (Cambridge, Massachusetts)
ABSTRACT	Techniques and devices including a biocompatible antibacterial film are provided. An example method for depositing a biocompatible antibacterial film using physical vapor deposition (PVD) includes providing a substrate in a PVD processing chamber, forming a deposited film by co-depositing a first material and a second material onto the substrate from a vapor plume, wherein at least the first material is biocompatible and at least the second material is antibacterial, and nano-texturing the deposited film to produce nano-scale surface asperities that provide at least one of inhibition of bacterial growth, promotion of osseointegration, promotion of epithelial attachment, or promotion of endothelial attachment.
FILED	Thursday, December 01, 2016
APPL NO	15/366021
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 6/58 (20200101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/306 (20130101) Original (OR) Class A61L 31/16 (20130101) A61L 31/088 (20130101) A61L 31/148 (20130101) A61L 2300/404 (20130101) A61L 2300/606 (20130101) A61L 2400/12 (20130101) A61L 2400/18 (20130101) A61L 2420/02 (20130101) A61L 2420/06 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/14 (20130101) C23C 14/24 (20130101) C23C 14/5833 (20130101) C23C 16/56 (20130101) C23C 16/405 (20130101)
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10675423 — Systems and methods for multi-frequency oscillatory ventilation

US 10675423	Kaczka et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	David Kaczka (Iowa City, Iowa); Jacob Herrmann (Coralville, Iowa)
ASSIGNEE(S)
INVENTOR(S)	David Kaczka (Iowa City, Iowa); Jacob Herrmann (Coralville, Iowa)
ABSTRACT	Oscillatory ventilator configured for oscillating at a plurality of specifically tuned sinusoidal frequencies simultaneously a ventilation gas for delivery to a lung region of a patient and a ventilator control system, in communication with the oscillatory ventilator, to control a sinusoidal waveform input for the oscillatory ventilator, wherein the sinusoidal waveform input comprises the plurality of specifically tuned sinusoidal frequencies each of which sinusoidal frequencies are below the acoustic range.
FILED	Wednesday, May 04, 2016
APPL NO	15/145880
ART UNIT	3785 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0006 (20140204) A61M 16/0057 (20130101) Original (OR) Class A61M 16/0096 (20130101) A61M 16/203 (20140204) A61M 2016/0027 (20130101) A61M 2016/0036 (20130101) A61M 2016/102 (20130101) A61M 2230/005 (20130101) A61M 2230/005 (20130101) A61M 2230/005 (20130101) A61M 2230/005 (20130101) A61M 2230/005 (20130101) A61M 2230/40 (20130101) A61M 2230/46 (20130101) A61M 2230/46 (20130101) A61M 2230/202 (20130101) A61M 2230/202 (20130101) A61M 2230/205 (20130101) A61M 2230/205 (20130101) A61M 2230/208 (20130101) A61M 2230/208 (20130101)
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10675618 — Integration of ex situ fabricated porous polymer monoliths into fluidic chips

US 10675618	Kendall et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)	University of Maryland, College Park (College Park, Maryland)
INVENTOR(S)	Eric L. Kendall (College Park, Maryland); Erik Wienhold (College Park, Maryland); Omid Rahmanian (College Park, Maryland); Don L. Devoe (College Park, Maryland)
ABSTRACT	Bare porous polymer monoliths, fluidic chips, methods of incorporating bare porous polymer monoliths into fluidic chips, and methods for functionalizing bare porous polymer monoliths are described. Bare porous polymer monoliths may be fabricated ex situ in a mold. The bare porous polymer monoliths may also be functionalized ex situ. Incorporating the bare preformed porous polymer monoliths into the fluidic chips may include inserting the monoliths into channels of channel substrates of the fluidic chips. Incorporating the bare preformed porous polymer monoliths into the fluidic chips may include bonding a capping layer to the channel substrate. The bare porous polymer monoliths may be mechanically anchored to channel walls and to the capping layer. The bare porous polymer monoliths may be functionalized by ex situ immobilization of capture probes on the monoliths. The monoliths may be functionalized by direct attachment of chitosan.
FILED	Friday, March 27, 2015
APPL NO	14/671250
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Separation B01D 2253/342 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/2485 (20130101) B01J 2219/2402 (20130101) B01J 2219/2433 (20130101) B01J 2220/82 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) B01L 3/5023 (20130101) Original (OR) Class B01L 3/502707 (20130101) B01L 3/502723 (20130101) B01L 3/502753 (20130101) B01L 2200/12 (20130101) B01L 2200/0631 (20130101) B01L 2300/16 (20130101) B01L 2300/165 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 222/1006 (20130101) C08F 2220/325 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/246 (20130101) C08J 9/36 (20130101) C08J 9/224 (20130101) C08J 9/286 (20130101) C08J 2201/026 (20130101) C08J 2205/022 (20130101) C08J 2205/024 (20130101) C08J 2207/00 (20130101) C08J 2333/10 (20130101) C08J 2333/14 (20130101) C08J 2335/02 (20130101)
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10676423 — Structure and synthesis of highly fluorinated amino acid derivatives

US 10676423	Weaver et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Board of Regents for Oklahoma State University (Stillwater, Oklahoma)
ASSIGNEE(S)	The Board of Regents for Oklahoma State University (Stillwater, Oklahoma)
INVENTOR(S)	Jimmie Dean Weaver (Stillwater, Oklahoma); Kip Allen Teegardin (Glencoe, Oklahoma); Amandeep Arora (Stillwater, Oklahoma)
ABSTRACT	Methods of synthesizing polyfluorinated amino acid derivatives are disclosed, along with polyfluorinated amino acid derivatives produced from said methods, as well as compositions containing same. The synthesis methods utilize an oxazolone and a perfluoroarene to produce the polyfluorinated amino acid derivatives.
FILED	Tuesday, February 20, 2018
APPL NO	16/483636
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 227/18 (20130101) Original (OR) Class C07C 277/08 (20130101) C07C 319/12 (20130101) Heterocyclic Compounds C07D 207/16 (20130101) C07D 209/20 (20130101) C07D 233/64 (20130101)
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10676449 — Electronically activated strained alkynes

US 10676449	Schomaker et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Jennifer M. Schomaker (Madison, Wisconsin); Eileen G. Burke (Somerville, Massachusetts)
ABSTRACT	Compounds of Formula I: wherein: R¹and R^1′ are independently selected from hydrogen, halogen, C₁-to-C₁₂linear or branched hydroxyalkyl, C₁-to-C₁₂linear or branched halo-alkyl, carboxy, carboxyalkyl, amido, N-alkylamido, N,N-dialkylamido, carbamoyloxy, N-alkylcarbamoyloxy, and N,N-dialkylcarbamoyloxy, provided that that R¹and R^1′ are not simultaneously hydrogen; R²and R^2′ hydrogen, halogen, C₁-to-C₁₂linear or branched hydroxyalkyl, C₁-to-C₁₂linear or branched halo-alkyl, carboxy, carboxyalkyl, amido, N-alkylamido, N,N-dialkylamido, carbamoyloxy, N-alkylcarbamoyloxy, and N,N-dialkylcarbamoyloxy, provided that that R²and R^2′ are not simultaneously hydrogen; R³is selected from hydrogen, C₁to C₁₂linear or branched alkyl, and nitrogen protecting groups; X is oxygen or nitrogen; when X is oxygen, R⁴is absent; and when X is nitrogen, R⁴is selected from H, C₁-to-C₁₂linear or branched alkyl, and nitrogen protecting groups.
FILED	Monday, February 25, 2019
APPL NO	16/284258
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 291/02 (20130101) Original (OR) Class
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10676455 — Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia

US 10676455	Tweardy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Baylor College of Medicine (Houston, Texas)
ASSIGNEE(S)	Baylor College of Medicine (Houston, Texas)
INVENTOR(S)	David J. Tweardy (Houston, Texas); Moses M. Kasembeli (Houston, Texas); Marvin X. Xu (Shanghai, China PRC); Thomas Kristian Eckols (Houston, Texas)
ABSTRACT	Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.
FILED	Friday, July 18, 2014
APPL NO	14/335853
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/42 (20130101) A61K 31/45 (20130101) A61K 31/47 (20130101) A61K 31/145 (20130101) A61K 31/357 (20130101) A61K 31/381 (20130101) A61K 31/404 (20130101) A61K 31/415 (20130101) A61K 31/428 (20130101) A61K 31/454 (20130101) A61K 31/513 (20130101) A61K 31/4035 (20130101) A61K 31/4164 (20130101) A61K 31/4196 (20130101) A61K 31/4406 (20130101) A61K 31/4704 (20130101) A61K 31/4709 (20130101) A61K 45/06 (20130101) Acyclic or Carbocyclic Compounds C07C 311/08 (20130101) C07C 311/10 (20130101) C07C 311/13 (20130101) C07C 311/21 (20130101) C07C 311/24 (20130101) C07C 311/29 (20130101) C07C 311/44 (20130101) C07C 323/49 (20130101) C07C 381/06 (20130101) C07C 2101/14 (20130101) C07C 2102/10 (20130101) C07C 2601/14 (20170501) C07C 2602/10 (20170501) Heterocyclic Compounds C07D 213/71 (20130101) C07D 215/36 (20130101) C07D 231/18 (20130101) C07D 319/18 (20130101) C07D 333/34 (20130101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 50/409 (20180101)
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10676464 — 5-hydroxytryptamine receptor 7 activity modulators and their method of use

US 10676464	Canney et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Temple University Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania)
INVENTOR(S)	Daniel J. Canney (Ambler, Pennsylvania); Benjamin E. Blass (Eagleville, Pennsylvania); Rong Gao (Eugene, Oregon); Magid Abou-Gharbia (Exton, Pennsylvania)
ABSTRACT	Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
FILED	Tuesday, May 14, 2019
APPL NO	16/411534
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Heterocyclic Compounds C07D 307/33 (20130101) C07D 307/94 (20130101) C07D 405/06 (20130101) C07D 405/12 (20130101) Original (OR) Class
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10676469 — Kappa opioid receptor antagonists and products and methods related thereto

US 10676469	Roberts et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Scripps Research Institute (La Jolla, California); BlackThorn Therapeutics, Inc. (South San Francisco, California)
ASSIGNEE(S)	BLACKTHORN THERAPEUTICS, INC. (San Francisco, California); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S)	Edward Roberts (Fallbrook, California); Miguel A. Guerrero (San Diego, California); Mariangela Urbano (Del Mar, California); Hugh Rosen (La Jolla, California); Robert M. Jones (South San Francisco, California); Candace Mae Laxamana (South San Francisco, California); Xianrui Zhao (South San Francisco, California); Eric Douglas Turtle (Belmont, California)
ABSTRACT	Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof: wherein X, Y, R¹, R², R⁴, R⁵R⁶, R⁷, R⁸and R¹¹are as defined herein.
FILED	Friday, March 16, 2018
APPL NO	15/924119
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/06 (20180101) Heterocyclic Compounds C07D 413/14 (20130101) Original (OR) Class
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10676475 — Compounds for improving mRNA splicing

US 10676475	Slaugenhaupt et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Susan A. Slaugenhaupt (Hignham, Massachusetts); Graham Johnson (Sanbornton, New Hampshire); William D. Paquette (Amsterdam, New York); Wei Zhang (Schenectady, New York); Juan Marugan (Gaithersburg, Maryland)
ABSTRACT	Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.
FILED	Friday, January 15, 2016
APPL NO	15/543826
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 405/12 (20130101) C07D 417/12 (20130101) C07D 471/04 (20130101) C07D 473/16 (20130101) C07D 473/34 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 495/04 (20130101) C07D 513/04 (20130101)
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10676480 — Anti-cancer compounds targeting Ral GTPases and methods of using the same

US 10676480	Theodorescu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate (Denver, Colorado)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate (Denver, Colorado)
INVENTOR(S)	Dan Theodorescu (Englewood, Colorado); Michael Fitzpatrick Wempe (Aurora, Colorado); David Ross (Niwot, Colorado); Chao Yan (Denver, Colorado); Phillip Reigan (Denver, Colorado)
ABSTRACT	Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
FILED	Monday, January 07, 2019
APPL NO	16/241587
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4162 (20130101) A61K 31/4162 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Heterocyclic Compounds C07D 491/052 (20130101) Original (OR) Class
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10676484 — Compositions and methods for treating leukemia

US 10676484	Bradner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Cold Spring Harbor Laboratory (Cold Spring Harbor, New York)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Cold Spring Harbor Institute (Cold Spring Harbor, New York)
INVENTOR(S)	James Elliott Bradner (Weston, Massachusetts); Johannes Zuber (Cold Spring Harbor, New York); Junwei Shi (Cold Spring Harbor, New York); Christopher R. Vakoc (Cold Spring Harbor, New York); Scott W. Lowe (New York, New York); Constantine S. Mitsiades (Boston, Massachusetts)
ABSTRACT	The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.
FILED	Tuesday, October 17, 2017
APPL NO	15/786249
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/5517 (20130101) Heterocyclic Compounds C07D 495/14 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) C12N 2330/51 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101)
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10676504 — Method for preparing largazole analogs and uses thereof

US 10676504	Williams et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Colorado State University Research Foundation (Fort Collins, Colorado); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); University of Notre Dame du Lac (South Bend, Indiana)
ASSIGNEE(S)	Colorado State University Research Foundation (Fort Collins, Colorado); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); University of Notre Dame du Lac (South Bend, Indiana)
INVENTOR(S)	Robert M. Williams (Fort Collins, Colorado); James E. Bradner (Weston, Massachusetts); Dane Clausen (Rahway, New Jersey); Olaf G. Wiest (South Bend, Indiana); Tenaya L. Newkirk (Denver, Colorado); Albert A. Bowers (Chapel Hill, North Carolina); Jennifer Marie Guerra (Henderson, Nevada)
ABSTRACT	Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
FILED	Thursday, March 03, 2016
APPL NO	15/555755
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/429 (20130101) A61K 31/429 (20130101) A61K 31/437 (20130101) A61K 31/437 (20130101) A61K 38/05 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/008 (20130101) C07B 2200/05 (20130101) Heterocyclic Compounds C07D 513/18 (20130101) Peptides C07K 5/06052 (20130101) Original (OR) Class
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10676509 — Surface-immobilized antimicrobial peptoids

US 10676509	Messersmith et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Phillip B. Messersmith (Clarendon Hills, Illinois); Annelise E. Barron (Palo Alto, California); Andrea Statz (Flagstaff, Arizona); Nathaniel Chongslriwatana (Albuquerque, New Mexico)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois)
INVENTOR(S)	Phillip B. Messersmith (Clarendon Hills, Illinois); Annelise E. Barron (Palo Alto, California); Andrea Statz (Flagstaff, Arizona); Nathaniel Chongslriwatana (Albuquerque, New Mexico)
ABSTRACT	Immobilizable antimicrobial compounds incorporating antimicrobial and/or antifouling components, as can be adhered to various device structures and components.
FILED	Friday, July 31, 2009
APPL NO	12/533876
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Cleaning in General; Prevention of Fouling in General B08B 17/06 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) Original (OR) Class C07K 14/001 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) C09D 5/1637 (20130101)
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10676510 — Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase

US 10676510	Lee et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	ST. JUDE CHILDREN'S RESEARCH HOSPITAL (Memphis, Tennessee)
ASSIGNEE(S)	St. Jude Children's Research Hospital (Memphis, Tennessee)
INVENTOR(S)	Richard E. Lee (Cordova, Tennessee); Ying Zhao (Memphis, Tennessee); Elizabeth Griffith (Germantown, Tennessee); Zhong Zheng (Irvine, California); Aman P. Singh (Memphis, Tennessee)
ABSTRACT	In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the C1pP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED	Friday, January 05, 2018
APPL NO	15/863673
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/15 (20130101) A61K 45/06 (20130101) Peptides C07K 7/06 (20130101) C07K 11/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/50 (20130101) Enzymes C12Y 304/21 (20130101) Technologies for Adaptation to Climate Change Y02A 50/471 (20180101) Y02A 50/475 (20180101) Y02A 50/481 (20180101)
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10676515 — Multimodal trail molecules expressed in T cells

US 10676515	Shah
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
ASSIGNEE(S)	THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
INVENTOR(S)	Khalid Shah (Andover, Massachusetts)
ABSTRACT	Described herein are novel compositions comprising multimodal TRAIL agents and cells engineered to express such multimodal TRAIL agents, including cells encapsulated in a scaffold or matrix, for use in the treatment of disorders such as cancer.
FILED	Thursday, June 21, 2018
APPL NO	16/014841
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2207/12 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/30 (20130101) A61K 38/1761 (20130101) A61K 38/1774 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 47/36 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/44 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/383 (20130101) A61L 27/3834 (20130101) A61L 27/3878 (20130101) A61L 2300/64 (20130101) A61L 2300/416 (20130101) Peptides C07K 14/4747 (20130101) Original (OR) Class C07K 2319/55 (20130101) C07K 2319/61 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) C12N 15/86 (20130101) C12N 2740/15043 (20130101) Enzymes C12Y 207/01145 (20130101)
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10676518 — A4B2 nicotinic acetylcholine receptors with reduced or increased nicotine sensitivity and transgenic mouse model for the same

US 10676518	Lasalde-Dominicci et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Jose A Lasalde-Dominicci (San Juan, Puerto Rico); Nilza M Biaggi-Labiosa (San Juan, Puerto Rico); Emir Aviles-Pagan (San Juan, Puerto Rico); Daniel Caballero-Rivera (San Juan, Puerto Rico)
ASSIGNEE(S)	University of Puerto Rico (San Juan, Puerto Rico)
INVENTOR(S)	Jose A Lasalde-Dominicci (San Juan, Puerto Rico); Nilza M Biaggi-Labiosa (San Juan, Puerto Rico); Emir Aviles-Pagan (San Juan, Puerto Rico); Daniel Caballero-Rivera (San Juan, Puerto Rico)
ABSTRACT	The α4β2 neuronal nicotinic acetylcholine receptor (nAChR) plays a crucial role in nicotine addiction. The invention studied the effect of subunit phosphorylation on α4β2 nAChR function and expression, and eleven residues located in the M3-M4 cytoplasmic loop were mutated to alanine and aspartic acid. When nicotine was used as an agonist, four mutations exhibited a statistically significant hypersensitivity to nicotine (S438D, S469A, Y576A, and S589A). Additionally, two mutations (S516D and T536A) that displayed normal activation with ACh displayed remarkable reductions in sensitivity to nicotine. The invention provides a knock-in mutant construct for the development of a transgenic mouse line with reduced nicotine sensitivity to be used in future studies.
FILED	Thursday, April 28, 2016
APPL NO	15/141689
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2217/054 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Peptides C07K 14/70571 (20130101) Original (OR) Class
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10676519 — Chimeric proteins and their use in identifying anti-deubiquitinase compounds

US 10676519	Tomko, Jr.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S)	The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
INVENTOR(S)	Robert J. Tomko, Jr. (Tallahassee, Florida)
ABSTRACT	A chimeric protein having deubiquitinase activity, methods of identifying anti-deubiquitinase compounds using chimeric proteins, and kits comprising chimeric proteins are described herein. In one aspect, a chimeric protein comprises a mammalian deubiquitinase catalytic domain, a linker domain, and a non-human deubiquitinase proteasome binding domain. In another aspect, a method of identifying a compound having deubiquitinase inhibition activity comprises a) providing an assay for identifying a compound having deubiquitinase inhibition activity, wherein the assay comprises one or more biological cells comprising a chimeric protein comprising a mammalian deubiquitinase catalytic domain, a linker domain, and a non-human deubiquitinase proteasome binding domain; b) screening the assay with at least one compound; and c) identifying a compound having deubiquitinase inhibition activity based on survival of the biological cell. In another aspect, a kit comprises a biological cell comprising a herein disclosed chimeric protein.
FILED	Friday, October 05, 2018
APPL NO	16/152881
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/48 (20130101) Peptides C07K 14/8103 (20130101) Original (OR) Class C07K 2319/03 (20130101) C07K 2319/50 (20130101) C07K 2319/74 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 15/62 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) G01N 2500/02 (20130101) G01N 2500/10 (20130101)
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10676521 — Combination of broadly neutralizing HIV antibodies and viral inducers

US 10676521	Nussenzweig et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Rockefeller University (New York, New York)
ASSIGNEE(S)	The Rockefeller University (New York, New York)
INVENTOR(S)	Michel Nussenzweig (New York, New York); Ariel Halper-Stromberg (New York, New York); Ching-Lan Lu (New York, New York)
ABSTRACT	The present invention relates to methods and agents for preventing the establishment of HIV-1 latent reservoirs or for reducing the size of the reservoirs. Specifically, the disclosure provides methods and agents for preventing the establishment of HIV-1 latent reservoirs or for reducing the size of the reservoirs, the methods comprising administering to the subject a therapeutically effective amount of an isolated anti-HIV antibody, and administering to the subject two or more viral transcription inducers in effective amounts to induce transcription of an HIV provirus in the cells. Further provided are antibodies and viral transcription inducers used in the methods.
FILED	Tuesday, July 21, 2015
APPL NO	15/327725
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/167 (20130101) A61K 31/185 (20130101) A61K 31/513 (20130101) A61K 31/685 (20130101) A61K 39/42 (20130101) A61K 39/395 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 16/1063 (20130101) Original (OR) Class C07K 2317/33 (20130101) C07K 2317/52 (20130101) C07K 2317/71 (20130101) C07K 2317/76 (20130101) C07K 2317/94 (20130101)
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10676527 — Methods and compositions for modulation of blood-neural barrier

US 10676527	Eriksson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Ludwig Institute for Cancer Research Ltd (Zurich, Switzerland); The Regents of the University of Michigan (Ann Arbor, Michigan); University of Maryland, Baltimore (Baltimore, Maryland)
ASSIGNEE(S)	Ludwig Institute for Cancer Research Ltd. (Zurich, Switzerland); The Regents of the University of Michigan (Ann Arbor, Michigan); University of Maryland, Baltimore (Baltimore, Maryland)
INVENTOR(S)	Ulf Eriksson (Stockholm, Sweden); Linda Fredriksson (Hagersten, Sweden); Daniel Lawrence (Ann Arbor, Michigan); Enming Su (Ann Arbor, Michigan); Manuel Yepes (Atlanta, Georgia); Dudley Strickland (Brookville, Maryland)
ABSTRACT	Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.
FILED	Monday, February 12, 2018
APPL NO	15/893925
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/00 (20130101) A61K 38/43 (20130101) A61K 39/3955 (20130101) A61K 39/39533 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/22 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6454 (20130101)
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10676528 — Thymic stromal lymphopoietin receptor-specific chimeric antigen receptors and methods using same

US 10676528	Qin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Haiying Qin (Potomac, Maryland); Terry J. Fry (Bethesda, Maryland)
ABSTRACT	The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain specific for TSLPR, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of a proliferative disorder, e.g., cancer, in a mammal and methods of treating or preventing a proliferative disorder, e.g., cancer, in a mammal are also disclosed.
FILED	Thursday, October 30, 2014
APPL NO	15/101583
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/7051 (20130101) C07K 14/7151 (20130101) C07K 14/70517 (20130101) C07K 16/2803 (20130101) C07K 16/2866 (20130101) Original (OR) Class C07K 16/3061 (20130101) C07K 2317/524 (20130101) C07K 2317/526 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101)
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10676529 — Antibodies against human and canine IL-13RA2

US 10676529	Debinski et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Wake Forest University Health Sciences (Winston-Salem, North Carolina)
ASSIGNEE(S)	Wake Forest University Health Sciences (Winston-Salem, North Carolina)
INVENTOR(S)	Waldemar Debinski (Winston-Salem, North Carolina); Denise Mazess Herpai (Winston-Salem, North Carolina)
ABSTRACT	Provided herein are monoclonal antibodies that specifically bind IL-13RA2 with cross-reactivity in humans and canines. Also provided are methods of use of the antibodies in the treatment and monitoring of cancers.
FILED	Friday, December 08, 2017
APPL NO	15/835566
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 47/6813 (20170801) A61K 47/6829 (20170801) A61K 47/6849 (20170801) A61K 47/6851 (20170801) A61K 47/6911 (20170801) A61K 49/0004 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/2866 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/56 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Enzymes C12Y 603/01004 (20130101)
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10676539 — Tissue plasminogen activator antibodies and methods of use

US 10676539	Reed
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
INVENTOR(S)	Guy Reed (Knoxville, Tennessee)
ABSTRACT	A molecule that binds specifically to a human tissue plasminogen activator (TPA) or a TPA mutant is provided. The molecule having sub-nanomolar affinity to inhibit fibrin-dependent plasminogen activation with an IC50<5 nM, to inhibit degradation of human fibron clots without affecting TPA amidolytic activity or non-fibrin-dependent activation, and the amino acid sequence of the TPA mutant is at least 65% identical to SEQ ID NO: 1 or SEQ ID NO: 2. Further provided is a method for treating systemic bleeding and brain hemorrhage after TPA treatment in a patient in need of such treatment. The method comprises administering to said patient an effective amount of the molecule, wherein the molecule selectively inhibits fibrin-augmented plasminogen activation in the patient.
FILED	Wednesday, November 14, 2018
APPL NO	16/191387
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/507 (20130101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 2317/33 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) G01N 33/573 (20130101) G01N 2333/96433 (20130101)
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10676715 — Assembly of functionally integrated human forebrain spheroids and methods of use thereof

US 10676715	Andersen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Jimena Andersen (Palo Alto, California); Fikri Birey (Palo Alto, California); Sergiu P. Pasca (Palo Alto, California)
ABSTRACT	Human pluripotent stem cells are differentiated in vitro into forebrain subdomain structures, which are then fused to generate an integrated system for use in analysis, screening programs, and the like.
FILED	Wednesday, March 28, 2018
APPL NO	15/938564
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 5/0623 (20130101) C12N 5/0696 (20130101) C12N 2501/01 (20130101) C12N 2501/11 (20130101) C12N 2501/13 (20130101) C12N 2501/15 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2506/45 (20130101)
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10676718 — Maintenance and propagation of mesenchymal stem cells

US 10676718	Chen et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)	The Board of Trustees of the University of Arkansas (Little Rock, Arkansas); The United States of America as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Xiao-Dong Chen (San Antonio, Texas); Robert L. Jilka (Little Rock, Arkansas)
ABSTRACT	Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
FILED	Thursday, January 11, 2018
APPL NO	15/868721
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 2035/124 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 25/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0662 (20130101) Original (OR) Class C12N 5/0663 (20130101) C12N 5/0668 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101)
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10676719 — Devices and methods for separating particles

US 10676719	Mao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	University of Georgia Research Foundation, Inc. (Athens, Georgia); Augusta University Research Institute, Inc. (Augusta, Georgia)
ASSIGNEE(S)	University of Georgia Research Foundation, Inc. (Athens, Georgia)
INVENTOR(S)	Leidong Mao (Athens, Georgia); Carsten Schroeder (Augusta, Georgia); Wujun Zhao (Athens, Georgia)
ABSTRACT	Devices for non-invasive, label-free separation of particles in liquid, including circulating tumors cells in blood, are provided. Embodiments of the disclosure provide for devices employing magnetic fluids and magnets for separation of circulating tumor cells from blood. Methods for separation of particles including circulating tumor cells are also provided.
FILED	Friday, July 29, 2016
APPL NO	15/223515
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 3/502776 (20130101) B01L 2200/0652 (20130101) B01L 2300/0816 (20130101) B01L 2300/0883 (20130101) B01L 2400/043 (20130101) B01L 2400/0487 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) Original (OR) Class C12N 5/0695 (20130101)
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10676721 — Bacteriophages expressing antimicrobial peptides and uses thereof

US 10676721	Collins et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD)
APPLICANT(S)	James J. Collins (Newton, Massachusetts); Michael Koeris (Natick, Massachusetts); Timothy Kuan-Ta Lu (Charlestown, Massachusetts); Gregory Stephanopoulos (Winchester, Massachusetts); Christopher Jongsoo Yoon (Seoul, South Korea)
ASSIGNEE(S)	Trustees of Boston University (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	James J. Collins (Newton, Massachusetts); Michael Koeris (Natick, Massachusetts); Timothy Kuan-Ta Lu (Charlestown, Massachusetts); Tanguy My Chau (Palo Alto, California); Gregory Stephanopoulos (Winchester, Massachusetts); Christopher Jongsoo Yoon (Seoul, South Korea)
ABSTRACT	The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enzymes or fragments thereof for targeting a broad spectrum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some embodiments, bacteriophages express antimicrobial peptides or antimicrobial polypeptides (e.g. phage lytic enzymes) which are secreted from the host bacteria, or alternatively released upon lysis of the bacterial host cell. Aspects of the present invention also relate to the use of the engineered bacteriophages for the reduction of bacterial infections, both in a subject or for bioremediation purposes, in clinical settings and wound healing.
FILED	Friday, September 02, 2011
APPL NO	13/224776
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 38/1767 (20130101) Peptides C07K 14/463 (20130101) C07K 14/43504 (20130101) C07K 14/43563 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 9/503 (20130101) C12N 2795/10221 (20130101) C12N 2795/10231 (20130101) C12N 2795/10232 (20130101) C12N 2795/12032 (20130101) C12N 2795/12043 (20130101) C12N 2795/14132 (20130101) C12N 2795/14143 (20130101)
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10676723 — Chimeric protein toxins for expression by therapeutic bacteria

US 10676723	Bermudes et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	David Gordon Bermudes (Woodland Hills, California); David Quintero (Northridge, California)
ASSIGNEE(S)
INVENTOR(S)	David Gordon Bermudes (Woodland Hills, California); David Quintero (Northridge, California)
ABSTRACT	Bacteria with tumor-targeting capability express, surface displayed, secreted and/or released modified chimeric therapeutic proteins with enhanced therapeutic activity against a neoplastic tissue including solid tumors, lymphomas and leukemias. The bacteria may be attenuated, non-pathogenic, low pathogenic or a probiotic. The chimeric proteins may be protease sensitive and may optionally be further accompanied by co-expression of a secreted protease inhibitor as a separate molecule or as a fusion.
FILED	Tuesday, May 10, 2016
APPL NO	15/151194
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 38/00 (20130101) A61K 2035/11 (20130101) Peptides C07K 14/005 (20130101) C07K 14/245 (20130101) C07K 14/415 (20130101) C07K 2319/00 (20130101) C07K 2319/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1077 (20130101) Original (OR) Class C12N 2750/10022 (20130101) C12N 2750/10033 (20130101) Enzymes C12Y 204/02036 (20130101)
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10676726 — Compositions and methods for epigenome editing

US 10676726	Gersbach et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Charles A. Gersbach (Durham, North Carolina); Isaac Hilton (Durham, North Carolina)
ABSTRACT	Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.
FILED	Tuesday, February 09, 2016
APPL NO	15/549842
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/1029 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 203/01048 (20130101)
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10676731 — Compositions and methods for modulating factor IX function

US 10676731	Camire et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Children's Hospital of Philadelphia (Philadelphia, Pennsylvania)
ASSIGNEE(S)	THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania)
INVENTOR(S)	Rodney M. Camire (Sicklerville, New Jersey); Lacramioara Ivanciu (Philadelphia, Pennsylvania); Valder R. Arruda (Philadelphia, Pennsylvania)
ABSTRACT	Factor IX/IXa variants and methods of use thereof are disclosed.
FILED	Wednesday, August 19, 2015
APPL NO	15/504874
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/745 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/644 (20130101) Original (OR) Class Enzymes C12Y 304/21022 (20130101)
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10676735 — High-throughput screening of regulatory element function with epigenome editing technologies

US 10676735	Gersbach et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA) NIH Office of the Director (NIHOD)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Charles A. Gersbach (Durham, North Carolina); Gregory E. Crawford (Chapel Hill, North Carolina); Timothy E. Reddy (Carrboro, North Carolina); Tyler S. Klann (Durham, North Carolina)
ABSTRACT	Disclosed herein are methods of using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based epigenomic editing systems for high-throughput screening of regulatory element function.
FILED	Friday, July 22, 2016
APPL NO	15/746653
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 14/4703 (20130101) C07K 14/4705 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/1079 (20130101) Original (OR) Class C12N 15/1079 (20130101) C12N 2740/16043 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2525/301 (20130101) C12Q 2563/107 (20130101) Enzymes C12Y 301/00 (20130101)
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10676738 — 5′ modified nucleosides and oligomeric compounds prepared therefrom

US 10676738	Prakash et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Isis Pharmaceuticals, Inc. (Carlsbad, California)
ASSIGNEE(S)	Ionis Pharmaceuticals, Inc. (Carlsbad, California)
INVENTOR(S)	Thazha P. Prakash (Carlsbad, California); Punit P. Seth (Carlsbad, California); Eric E. Swayze (Encinitas, California)
ABSTRACT	The present disclosure provides double stranded nucleic acid comprising first and second oligonucleotides wherein the second oligonucleotide is complementary to the first oligonucleotide. At least one of the first and second oligonucleotides comprises a 5′ modified nucleoside or 5′ modified nucleotide having Formula IIb: wherein Bx is a heterocyclic base moiety, T₂is an internucleoside linking group linked to one of the oligonucleotides, and each of q₁to q₇are selected from a list of substituents. In certain embodiments, T2 is a phosphodiester or phosphorothioate linkage and formula IIb is a 5′-nucleotide. In certain embodiments, T2 is a non-phosphate linkage and formula IIb is a 5′-nucleoside. In certain embodiments, the present double stranded nucleic acid provides oligonucleotides that are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
FILED	Tuesday, July 28, 2015
APPL NO	14/810995
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/10 (20130101) C07H 19/067 (20130101) C07H 21/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/32 (20130101) C12N 2320/30 (20130101)
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10676744 — Modulation of adipose tissue macrophage phenotype by use of MicroRNA-30

US 10676744	Miranda et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Environmental Health Sciences (NIEHS) National Institute of General Medical Sciences (NIGMS) National Institute of Mental Health (NIMH)
APPLICANT(S)	University of South Carolina (Columbia, South Carolina)
ASSIGNEE(S)	University of South Carolina (Aiken, South Carolina)
INVENTOR(S)	Kathryn Miranda (Colubmia, South Carolina); Prakash Nagarkatti (Columbia, South Carolina); Mitzi Nagarkatti (Columbia, South Carolina)
ABSTRACT	MicroRNA-30 is identified as being dysregulated in adipose tissue macrophages during obesity and can be used in treatment of disease in which adipose tissue macrophage polarization dysregulation plays a part. Increased concentration of microRNA-30, e.g., via pharmaceutical delivery, can decrease the polarization of macrophages, and in particular adipose tissue macrophages, to inflammatory M1 phenotype and can decrease expression of pro-inflammatory cytokines. One or more members of the miR-30 family can be utilized in the methods. Methods can be beneficial in treatment of a large number of inflammatory diseases including obesity, diabetes, cancer, autoimmune, etc.
FILED	Monday, April 30, 2018
APPL NO	15/966171
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1136 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/141 (20130101) C12N 2310/3231 (20130101)
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10676746 — Methods for identifying therapeutic targets and treating monitoring cancers

US 10676746	Kemp et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Fred Hutchinson Cancer Research Center (Seattle, Washington)
ASSIGNEE(S)	Fred Hutchinson Cancer Research Center (Seattle, Washington)
INVENTOR(S)	Christopher Kemp (Seattle, Washington); Carla Grandori (Seattle, Washington); Eduardo Mendez (Seattle, Washington); Russell Moser (Seattle, Washington); Chang Xu (Mercer Island, Washington)
ABSTRACT	The present invention provides methods for treating cancers having a mutation in one or more tumor suppressor genes, comprising providing to a subject in need thereof an inhibitor of a kinase, as well as related methods and compositions.
FILED	Friday, November 21, 2014
APPL NO	15/038342
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/407 (20130101) A61K 31/407 (20130101) A61K 31/426 (20130101) A61K 31/426 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/519 (20130101) A61K 31/713 (20130101) A61K 31/4535 (20130101) A61K 31/4535 (20130101) A61K 31/5377 (20130101) A61K 31/5377 (20130101) A61K 33/24 (20130101) A61K 33/24 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 2800/52 (20130101)
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10676749 — Tale transcriptional activators

US 10676749	Joung et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Human Genome Research Institute (NHGRI) NIH Office of the Director (NIHOD) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	J. Keith Joung (Winchester, Massachusetts); Morgan Maeder (Brookline, Massachusetts)
ABSTRACT	Computer programs, algorithms, and methods for identifying TALE-activator binding sites, and methods for generation and use of TALE-activators that bind to these sites.
FILED	Friday, February 07, 2014
APPL NO	14/766713
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 14/435 (20130101) C07K 14/4702 (20130101) C07K 2319/71 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2710/16622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201)
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10676751 — Production and use of plant degrading materials

US 10676751	Daniell
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) Department of Agriculture (USDA) Agricultural Research Service (ARS) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Henry Daniell (Winter Park, Florida)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Henry Daniell (Winter Park, Florida)
ABSTRACT	Disclosed herein are materials useful for degrading plant biomass material. In exemplary embodiments, the plant material comprises one or more enzymes that are expressed in plants and/or bacteria. Specifically exemplified herein are plant degrading enzymes expressed in chloroplasts. The chloroplast expressed enzymes may be provided as cocktails for use in conjunction with conventional methods of converting biomass into biofuels, such as cellulosic ethanol.
FILED	Monday, March 02, 2009
APPL NO	12/396382
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2437 (20130101) C12N 9/2445 (20130101) C12N 9/2482 (20130101) C12N 15/8214 (20130101) Original (OR) Class C12N 15/8242 (20130101) C12N 15/8257 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/12 (20130101) Enzymes C12Y 302/01004 (20130101) C12Y 302/01008 (20130101) C12Y 302/01021 (20130101) C12Y 302/01091 (20130101)
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10676759 — Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

US 10676759	Doudna et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California); University of Vienna (Vienna, Austria); Emmanuelle Charpentier (Braunschweig, Germany)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California); University of Vienna (Vienna, Austria); Emmanuelle Charpentier (Braunschweig, Germany)
INVENTOR(S)	Jennifer A. Doudna (Berkeley, California); Martin Jinek (Berkeley, California); Krzysztof Chylinski (Vienna, Austria); Emmanuelle Charpentier (Braunschweig, Germany)
ABSTRACT	The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
FILED	Friday, April 12, 2019
APPL NO	16/383433
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/4684 (20180501) Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/746 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/13 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/31 (20130101) C12N 2310/32 (20130101) C12N 2310/33 (20130101) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Enzymes C12Y 301/04 (20130101)
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10676792 — Prognostic and diagnostic methods for colorectal cancer

US 10676792	Roose et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Jeroen Roose (Mill Valley, California); Philippe Depeille (San Francisco, California); Robert Warren (San Francisco, California)
ABSTRACT	Provided herein are methods for selecting a drug therapy for a patient with cancer, such as colorectal cancer, pancreatic cancer, lung cancer or breast cancer. The method includes determining or measuring the level of RasGRP1 polynucleotide or polypeptide in a sample from the patient. Also provided herein are methods for determining the likelihood of a good prognosis for a patient with cancer. Additionally, provided herein are methods for predicting the likelihood of a negative clinical response to an anti-EGFR therapy in a subject with cancer.
FILED	Thursday, March 31, 2016
APPL NO	15/563493
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57419 (20130101) G01N 33/57484 (20130101) G01N 2800/52 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) Technologies for Adaptation to Climate Change Y02A 90/26 (20180101)
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10677799 — Cathepsin K as a marker for cartilage production, repair and regeneration

US 10677799	Yang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR)
APPLICANT(S)	Rhode Island Hospital (Providence, Rhode Island)
ASSIGNEE(S)	Rhode Island Hospital (Providence, Rhode Island)
INVENTOR(S)	Wentian Yang (Pawtucket, Rhode Island); Nikhil Thakur (Atlanta, Georgia)
ABSTRACT	Ctsk is used as a marker to identify, track, and manipulate Ctsk positive cartilaginous stem cells for cartilage repair and regeneration in vitro and in vivo.
FILED	Friday, March 15, 2013
APPL NO	13/833403
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0655 (20130101) C12N 5/0662 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 33/5005 (20130101) G01N 33/5073 (20130101) G01N 2333/96466 (20130101)
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10677800 — Biomarkers for diagnosis and prognosis of lung cancer

US 10677800	Jiang
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Feng Jiang (Ellicott City, Maryland)
ASSIGNEE(S)	University of Maryland, Baltimore (Baltimore, Maryland); The United States of America as Represented by the Department of Veterans Affairs (Washington, None)
INVENTOR(S)	Feng Jiang (Ellicott City, Maryland)
ABSTRACT	Provided herein are methods for non-invasively diagnosing and/or prognosing a lung cancer and for determining the efficacy of a therapeutic treatment regimen for the lung cancer. Expression levels of at least two small non-coding RNAs, for example, microRNAs and small nucleolar RNAs, are measured and used to calculate an area under the curve (AUC) that provides a probability of lung cancer in the subject. The smoking history of the subject and, if present, the size of pulmonary nodules may be incorporated into the calculation.
FILED	Thursday, September 14, 2017
APPL NO	15/704828
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) Original (OR) Class G01N 2800/7028 (20130101)
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10677869 — pH-weighted MRI using fast amine chemical exchange saturation transfer (CEST) imaging

US 10677869	Ellingson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Benjamin Ellingson (Los Angeles, California); Robert Harris (Los Angeles, California)
ABSTRACT	A pH-weighted chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) method and system are provided that works by indirectly measuring the NMR signal from amine protons found on the backbones of amino acids and other metabolites, which resonate at a frequency of +2.8-3.2 ppm with respect to bulk water protons. The technique uses a modified magnetization transfer radiofrequency saturation pulse for the generation of image contrast. A train of three 100 ms Gaussian pulses at high amplitude (6 uT) or Sinc3 pulses are played at a particular frequency off-resonance from bulk water prior to a fast echo planar imaging (EPI) readout, with one full image acquired at each offset frequency. This non-invasive pH-weighted MRI technique does not require exogenous contrast agents and can be used in preclinical investigations and clinical monitoring in patients with malignant glioma, stroke, and other ailments.
FILED	Friday, May 27, 2016
APPL NO	15/577664
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/08 (20130101) G01N 33/48 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4616 (20130101) G01R 33/4804 (20130101) G01R 33/4838 (20130101) G01R 33/5605 (20130101) Original (OR) Class G01R 33/5616 (20130101) G01R 33/56509 (20130101) G01R 33/56563 (20130101)
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10677874 — System and method for control of hyperpolarized gas-phase contamination in spectroscopic magnetic resonance imaging

US 10677874	Fain et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Sean Fain (Madison, Wisconsin); Andrew Hahn (Madison, Wisconsin); Jeffrey Kammerman (Madison, Wisconsin)
ABSTRACT	A system and method is provided to acquire images of a subject having received a tissue soluble hyperpolarized gas into the airways. The method includes performing a pulse sequence including (i) for each effective repetition time (TReff), acquiring at least one gas-phase dataset and at least one dissolved-phase dataset, wherein a gas-phase echo time (TEGas) of the at least one gas-phase dataset and a dissolved-phase echo time (TEDissolved) of the at least one dissolved-phase dataset are selected to isolate gas-phase contamination of the dissolved-phase dataset from dissolved-phase components in the dissolved-phase dataset. The method also includes (ii) estimating gas-phase contamination of the dissolved-phase dataset using the gas-phase dataset and a scaling factor (σ), (iii) producing a corrected dissolved-phase dataset by reducing the gas-phase contamination of the dissolved-phase dataset using the gas-phase contamination estimated in step (ii), and reconstructing an image from the corrected dissolved-phase dataset and the gas-phase dataset.
FILED	Tuesday, February 20, 2018
APPL NO	15/900256
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/282 (20130101) G01R 33/385 (20130101) G01R 33/543 (20130101) G01R 33/4824 (20130101) G01R 33/4828 (20130101) G01R 33/5601 (20130101) G01R 33/5608 (20130101) G01R 33/56527 (20130101) Original (OR) Class
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10678037 — Reverberation microscopy systems and methods

US 10678037	Mertz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)	Trustees of Boston University (Boston, Massachusetts)
INVENTOR(S)	Jerome Charles Mertz (Newton, Massachusetts); Devin Robert Beaulieu (Brookline, Massachusetts); Thomas Gary Bifano (Mansfield, Massachusetts)
ABSTRACT	A method for obtaining one or more images of a sample using a microscope includes dividing, using a reverberation cavity, a first one of a plurality of laser pulses into a plurality of sequential sub-pulses, each of the plurality of sequential sub-pulses having a power that is less than a previous one of the plurality of sequential sub-pulses, directing, using the one or more lenses of the microscope, the plurality of sequential sub-pulses onto a portion of the sample to generate a plurality of signals, each of the plurality of signals being associated with a different depth within the sample, and detecting the plurality of signals from the sample to generate one or more images of at least a portion of the sample.
FILED	Friday, July 12, 2019
APPL NO	16/510407
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6402 (20130101) G01N 21/6458 (20130101) G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) Original (OR) Class G02B 21/0048 (20130101) G02B 21/0076 (20130101)
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10678039 — Cooling systems and methods for cryo super-resolution fluorescence light microscopy and other applications

US 10678039	Ingersoll et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD)
APPLICANT(S)	Brandeis University (Waltham, Massachusetts)
ASSIGNEE(S)	Brandeis University (Waltham, Massachusetts)
INVENTOR(S)	Charles G. Ingersoll (Winthrop, Massachusetts); David J. Derosier (Newton, Massachusetts); Gina Turrigiano (Weston, Massachusetts); Marc Nahmani (Arlington, Massachusetts)
ABSTRACT	New systems and methods are described for maintaining a desired steady state temperature differential between two objects that may otherwise undergo heat transfer to restore thermal steady state. In one application, a cooling microscope assembly and its use with conventional optical microscopes are described for achieving super-resolution imaging. The assembly allows for the high resolution imaging of samples at cryogenic temperatures while maintaining the temperature of the objective lens above freezing by employing circulation systems and a coupling fluid between the sample and objective lens.
FILED	Wednesday, May 17, 2017
APPL NO	15/597506
ART UNIT	2872 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/28 (20130101) Original (OR) Class G02B 21/32 (20130101) G02B 21/33 (20130101)
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10679347 — Systems and methods for ultrasound imaging

US 10679347	Mauldin, Jr. et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	Rivanna Medical LLC (Charlottesville, Virginia)
ASSIGNEE(S)	Rivanna Medical LLC (Charlottesville, Virginia)
INVENTOR(S)	Frank William Mauldin, Jr. (Charlottesville, Virginia); Kevin Owen (Crozet, Virginia)
ABSTRACT	In some embodiments, a method comprises: obtaining a 2D ultrasound image of an imaged region of a subject, the imaged region comprising bone; identifying model template cross-sections of a 3D model of the bone corresponding to the 2D image at least in part by registering the 2D ultrasound image to the 3D model, wherein the model template cross-sections are defined prior to obtaining such 2D image, the model template cross-sections having size and shape representative of a population of potential subjects; identifying at least one location of at least one landmark feature of the bone in the 2D image based on results of the registration; and generating a visualization that includes: a visualization of the 2D image and a visualization of one of the identified cross-sections of the 3D model, wherein the visualization indicates the at least one location of the at least one landmark feature.
FILED	Thursday, June 14, 2018
APPL NO	16/008743
ART UNIT	2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/461 (20130101) A61B 8/0858 (20130101) A61B 8/0875 (20130101) A61B 8/5223 (20130101) A61B 8/5246 (20130101) A61B 8/5269 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/52 (20130101) G06K 9/4661 (20130101) G06K 2009/4666 (20130101) Image Data Processing or Generation, in General G06T 5/009 (20130101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/30 (20170101) G06T 11/60 (20130101) G06T 15/08 (20130101) G06T 2200/04 (20130101) G06T 2207/10132 (20130101) G06T 2207/30008 (20130101)
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10679488 — System and method for improving compliance with one or more protocols including hand hygiene and personal protective equipment protocols

US 10679488	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Nursing Research (NINR) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Microsensor Labs, LLC (Chicago, Illinois)
ASSIGNEE(S)	Microsensor Labs, LLC (Chicago, Illinois)
INVENTOR(S)	Peng Liu (Chicago, Illinois); Yang Liu (Beijing, China PRC); Jiapeng Huang (Louisville, Kentucky)
ABSTRACT	A system and method for detecting personal protective equipment (PPE) compliance is disclosed. Personal protective equipment, such as gloves, gowns, masks, protective eyewear, may be used to limit transmission of illness either from the patient to the care giver or vice-versa. Compliance with PPE is important in various contexts, including hospital settings, home settings, work settings, and school settings. For example, a healthcare provider may wear a wristband, which may interact with a stationary controller that is associated with an entrance and/or an exit to an area for the patient (such as the stationary controller integrated with or proximate to a hand cleaning agent dispenser) proximate to the entrance and/or exit. The interaction may be used to determine whether the healthcare provider has complied with PPE protocols. Further, the system may be used to train healthcare providers or others in PPE hygiene. In addition, the wristband may be used to check for compliance of a plurality of protocols, such as PPE protocols and hand hygiene (HH) protocols. In this way, the system may be used for safely interacting with patients in order to reduce cross-contamination.
FILED	Monday, October 01, 2018
APPL NO	16/148683
ART UNIT	2686 — Audio Signals
CURRENT CPC	Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/245 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/20 (20180101) G16H 50/30 (20180101)
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10679728 — Method of characterizing sequences from genetic material samples

US 10679728	Craig et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (Phoenix, Arizona); The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Translational Genomics Research Institute (Phoenix, Arizona); The Regents of the University of California (Oakland, California)
INVENTOR(S)	David Craig (Chandler, Arizona); Nils Homer (Los Angeles, California)
ABSTRACT	Among other aspects provided herein is a method describing the use of Single Nucleotide Polymorphism (SNP) genotyping microarrays to resolve whether genetic material (such as genomic DNA) derived from a particular individual is present in a genetic material mixture (such as a complex genomic DNA mixture) is disclosed. Furthermore, it is demonstrated that the identification of the presence of genetic material (such as genomic DNA) of specific individuals within a series of complex genomic mixtures is possible.
FILED	Monday, April 03, 2017
APPL NO	15/477808
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) Original (OR) Class G16B 25/00 (20190201) G16B 40/00 (20190201)
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10679730 — Prognostic and predictive breast cancer signature

US 10679730	Rosner et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD)
APPLICANT(S)	The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)	The University of Chicago (Chicago, Illinois)
INVENTOR(S)	Marsha Rosner (Chicago, Illinois); Miao Sun (Chicago, Illinois); Unjin Lee (Chicago, Illinois)
ABSTRACT	Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating a specified set of genes. Specifically, methods may comprise calculating a prognosis score based on a particular algorithm. Also disclosed are compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more upstream activators and/or downstream effectors of TET1.
FILED	Wednesday, November 25, 2015
APPL NO	14/952265
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/167 (20130101) A61K 31/405 (20130101) A61K 31/506 (20130101) A61K 31/706 (20130101) A61K 31/7068 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) G01N 2800/52 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) Original (OR) Class
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10679763 — Fourier ptychographic imaging systems, devices, and methods

US 10679763	Zheng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Guoan Zheng (Vernon, Connecticut); Changhuei Yang (Alhambra, California); Roarke Horstmeyer (San Marino, California)
ABSTRACT	Systems, devices, and methods of Fourier ptychographic imaging configured for illuminating a specimen being imaged from a plurality of incidence angles, for acquiring variably-illuminated, low-resolution intensity images of the specimen, and for reconstructing a high-resolution image of the specimen by iteratively determining the high resolution image that is self-consistent with the variably-illuminated, low-resolution intensity images, for example, by updating overlapping regions of variably-illuminated, low-resolution intensity images in Fourier space.
FILED	Monday, October 28, 2013
APPL NO	14/065280
ART UNIT	2485 — Recording and Compression
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 21/002 (20130101) G02B 21/365 (20130101) G02B 21/367 (20130101) G02B 27/58 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00134 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 7/00 (20130101) Original (OR) Class
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10679765 — Thermoplastic carbon composite electrodes

US 10679765	Henry et al.
FUNDED BY	Department of Health and Human Services (HHS) Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) National Science Foundation (NSF)
APPLICANT(S)	Colorado State University Research Foundation (Fort Collins, Colorado)
ASSIGNEE(S)	Colorado State University Research Foundation (Fort Collins, Colorado)
INVENTOR(S)	Charles S. Henry (Fort Collins, Colorado); Kevin Klunder (Fort Collins, Colorado)
ABSTRACT	A new solvent-based method is presented for making low-cost composite graphite electrodes containing a thermoplastic binder. The electrodes, termed thermoplastic electrodes (TPEs), are easy to fabricate and pattern, give excellent electrochemical performance, and have high conductivity (1500 S m⁻¹). The thermoplastic binder enables the electrodes to be hot embossed, molded, templated, and/or cut with a CO₂laser into a variety of intricate patterns. These electrodes show a marked improvement in peak current, peak separation, and resistance to charge transfer over traditional carbon electrodes. The impact of electrode composition, surface treatment (sanding, polishing, plasma treatment), and graphite source were found to impact fabrication, patterning, conductivity, and electrochemical performance. Under optimized conditions, electrodes generated responses similar to more expensive and difficult to fabricate graphene and highly oriented pyrolytic graphite electrodes. These TPE electrodes provide an approach for fabricating high-performance carbon electrodes with applications ranging from sensing to batteries.
FILED	Tuesday, August 06, 2019
APPL NO	16/533259
ART UNIT	1781 — Miscellaneous Articles, Stock Material
CURRENT CPC	Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/24 (20130101) Original (OR) Class H01B 13/0036 (20130101)
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10680231 — Mesoporous nickel-iron-manganese-alloy based metal/metal oxide composite thick film catalysts

US 10680231	Tolbert et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Sarah Tolbert (Los Angeles, California); Eric Detsi (Philadelphia, Pennsylvania); Benjamin Lesel (Los Angeles, California)
ABSTRACT	Selective alloy corrosion is used to synthesize a robust and ultrafine mesoporous NiFeMn-based metal/metal oxide oxygen evolving catalyst with ligament and pore sizes in the range of 10 nm and a BET surface area of 43 m²/g. As an oxygen evolving catalyst, the mesoporous catalyst exhibits high stability (>264 hours) at a high current density (500 mA/cm²) with a low overpotential (360 mV) using a moderate electrolyte concentration (1 M KOH). The catalyst is made from non-precious metals and its fabrication is straight forward and directly applicable to large-scale synthesis.
FILED	Sunday, May 27, 2018
APPL NO	15/990650
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/78 (20130101) B01J 23/80 (20130101) B01J 23/8476 (20130101) B01J 23/8892 (20130101) B01J 35/0033 (20130101) B01J 35/1014 (20130101) B01J 35/1061 (20130101) B01J 37/06 (20130101) B01J 2523/00 (20130101) B01J 2523/00 (20130101) B01J 2523/72 (20130101) B01J 2523/842 (20130101) B01J 2523/847 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Alloys C22C 38/04 (20130101) C22C 38/08 (20130101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/00 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/10 (20130101) C25B 9/08 (20130101) C25B 11/035 (20130101) C25B 11/0447 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/02 (20130101) Original (OR) Class H01M 8/0232 (20130101) H01M 2004/021 (20130101) H01M 2004/027 (20130101) H01M 2004/028 (20130101) H01M 2300/0005 (20130101) H01M 2300/0014 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/366 (20130101)
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10680401 — Sources of optical radiation and methods for providing low-speckle optical radiation, and systems and methods using them

US 10680401	Redding et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Brandon Redding (New Haven, Connecticut); Peyman Ahmadi (Manchester, Connecticut); Martin Seifert (West Simsbury, Connecticut); Hui Cao (New Haven, Connecticut)
ASSIGNEE(S)	Nufern (East Granby, Connecticut); Yale University (New Haven, Connecticut)
INVENTOR(S)	Brandon Redding (New Haven, Connecticut); Peyman Ahmadi (Manchester, Connecticut); Martin Seifert (West Simsbury, Connecticut); Hui Cao (New Haven, Connecticut)
ABSTRACT	The present disclosure relates more particularly to active optical fibers, amplified spontaneous emission (ASE) sources using such active optical fibers, and imaging and detection systems and methods using such ASE sources. In one aspect, the disclosure provides an active optical fiber that includes a rare earth-doped gain core configured to emit radiation at at least a peak wavelength emitted wavelength when pumped with pump radiation having a pump wavelength; a pump core surrounding the gain core; and a cladding surrounding the pump core, wherein the value M=16R²(NA)²/λ²in which R is the gain core radius, NA is the active optical fiber numerical aperture, and λ is the peak emitted wavelength, is at least 50, or at least 100. The present disclosure also provides an optical source that includes the optical fiber coupled to a pump source.
FILED	Tuesday, May 31, 2016
APPL NO	15/168981
ART UNIT	2874 — Optics
CURRENT CPC	Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/14 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) G01J 3/108 (20130101) G01J 3/0218 (20130101) G01J 3/1895 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4818 (20130101) G01S 7/4911 (20130101) G01S 17/00 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0078 (20130101) H01S 3/1603 (20130101) H01S 3/1618 (20130101) H01S 3/06729 (20130101) H01S 3/094007 (20130101) Original (OR) Class H01S 2301/02 (20130101)
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Department of Defense (DOD)

10674914 — Wireless neural interface system

US 10674914	Halpern et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Modular Bionics Inc. (Santa Ana, California)
ASSIGNEE(S)	Modular Bionics Inc. (Berkeley, California)
INVENTOR(S)	Ian Loren Halpern (San Francisco, California); Mark William Merlo (Santa Ana, California)
ABSTRACT	A device system and method for wirelessly communicating through tissue is provided. The device system comprises an implanted device with an array of antennas aligned with a tandem device with an array of antennas outside of the body. The two devices wirelessly communicate in a bi-directional manner. The implanted device can act as a physiological sensor and stimulator, and the external device can act as a controller and relay. Such configurations allow for a range of uses within research and clinical settings.
FILED	Friday, June 24, 2016
APPL NO	15/192905
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0031 (20130101) Original (OR) Class A61B 5/686 (20130101) A61B 5/04001 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36139 (20130101) A61N 1/37229 (20130101) Transmission H04B 1/7163 (20130101)
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10674943 — Method and system of rapid screening for mild traumatic brain injury (MTBI) and other cognitive impairment by analysis of intra-individual variability of motor performance

US 10674943	Dromerick et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC) Telemedicine and Advanced Technology Research Center (TATRC)
APPLICANT(S)	Medstar Health Research Institute, Inc. (Washington, District of Columbia); Georgetown University (Washington, District of Columbia)
ASSIGNEE(S)	MEDSTAR HEALTH RESEARCH INSTITUTE, INC. (Washington, District of Columbia); GEORGETOWN UNIVERSITY (Washington, District of Columbia)
INVENTOR(S)	Alexander Dromerick (Washington, District of Columbia); Peter S. Lum (Clarksville, Maryland); Rochelle E. Tractenberg (Silver Spring, Maryland)
ABSTRACT	A non-invasive system, and method for simple, quantitative screening for mTBI and other forms of mid cognitive impairment using a visuo-motor performance test (for example, a submaximal grip test) in response to visual feedback to quantitatively measure the intra-individual variability of performance metric for initial screening of patients with mild traumatic brain injury (mTBI), and other neurological disorders. The system and method can be administered in minutes, by any level of caregiver, in any environment including military in-the-field or sports on-field deployments, and is useful in screening those truly injured from those disguising or mimicking injury. In addition to screening, the system and method can be used to monitor and/or detect changes to intra-individual variability over time by comparison to a baseline, which in turn is helpful in determining estimated recovery trajectory or other related information.
FILED	Friday, September 06, 2013
APPL NO	14/426901
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/18 (20130101) A61B 5/162 (20130101) A61B 5/225 (20130101) A61B 5/1124 (20130101) Original (OR) Class A61B 5/4064 (20130101) A61B 5/4088 (20130101) A61B 2503/10 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101)
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10674955 — System and method for monitoring the health of joints

US 10674955	Song et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	Gangbing Song (Pearland, Texas); Yue Yu (New York, New York); Philip C. Noble (Houston, Texas)
ASSIGNEE(S)	University of Houston (Houston, Texas)
INVENTOR(S)	Gangbing Song (Pearland, Texas); Yue Yu (New York, New York); Philip C. Noble (Houston, Texas)
ABSTRACT	A system and method for detecting lubrication conditions, lubrication regimes, impingement, stick-slip, and/or surface damage allows the health of a joint to be monitored. The system and method provides in situ or in vivo real-time monitoring of dynamic and static conditions of the joint. The monitoring system may use both passive and active sensing approaches that employ strategically placed piezoelectric transducers on/in the articulating components of the joint. In some embodiments, the transducers may be Lead Zirconate Titanate (PZT) transducers. Active sensing may be used to detect lubrication regimes under static and dynamic conditions. Passive sensing may be used to characterize the joint motion and abnormities, such as impingements and surface damages.
FILED	Thursday, August 15, 2013
APPL NO	13/968018
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/4528 (20130101) Original (OR) Class A61B 8/0858 (20130101) A61B 8/0875 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/32 (20130101) A61F 2/468 (20130101) A61F 2002/481 (20130101) A61F 2002/488 (20130101) A61F 2002/30087 (20130101) A61F 2002/30673 (20130101)
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10675267 — Methods for detection and eradication of myeloid leukemia stem cells

US 10675267	Jamieson et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Regents Of The University Of California (San Francisco, California)
ASSIGNEE(S)	The Regents Of The University Of California (Oakland, California)
INVENTOR(S)	Catriona H.m. Jamieson (La Jolla, California); Leslie C. Robertson (La Jolla, California); Larisa Balaian (San Diego, California); James J. La Clair (San Diego, California); Reymundo Villa (San Mateo, California); Heather Leu (Walnut, California); Nathaniel Delos Santos (San Diego, California); Michael D. Burkart (La Jolla, California)
ABSTRACT	There are provided, inter alia, methods and compositions for diagnosis and treatment of acute myeloid leukemia (AML), secondary acute myeloid leukemia (sAML), and age-related diseases.
FILED	Friday, September 23, 2016
APPL NO	15/761983
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0695 (20130101) C12N 2501/999 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2333/912 (20130101) G01N 2333/70585 (20130101)
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10675618 — Integration of ex situ fabricated porous polymer monoliths into fluidic chips

US 10675618	Kendall et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)	University of Maryland, College Park (College Park, Maryland)
INVENTOR(S)	Eric L. Kendall (College Park, Maryland); Erik Wienhold (College Park, Maryland); Omid Rahmanian (College Park, Maryland); Don L. Devoe (College Park, Maryland)
ABSTRACT	Bare porous polymer monoliths, fluidic chips, methods of incorporating bare porous polymer monoliths into fluidic chips, and methods for functionalizing bare porous polymer monoliths are described. Bare porous polymer monoliths may be fabricated ex situ in a mold. The bare porous polymer monoliths may also be functionalized ex situ. Incorporating the bare preformed porous polymer monoliths into the fluidic chips may include inserting the monoliths into channels of channel substrates of the fluidic chips. Incorporating the bare preformed porous polymer monoliths into the fluidic chips may include bonding a capping layer to the channel substrate. The bare porous polymer monoliths may be mechanically anchored to channel walls and to the capping layer. The bare porous polymer monoliths may be functionalized by ex situ immobilization of capture probes on the monoliths. The monoliths may be functionalized by direct attachment of chitosan.
FILED	Friday, March 27, 2015
APPL NO	14/671250
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Separation B01D 2253/342 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/2485 (20130101) B01J 2219/2402 (20130101) B01J 2219/2433 (20130101) B01J 2220/82 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) B01L 3/5023 (20130101) Original (OR) Class B01L 3/502707 (20130101) B01L 3/502723 (20130101) B01L 3/502753 (20130101) B01L 2200/12 (20130101) B01L 2200/0631 (20130101) B01L 2300/16 (20130101) B01L 2300/165 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 222/1006 (20130101) C08F 2220/325 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/246 (20130101) C08J 9/36 (20130101) C08J 9/224 (20130101) C08J 9/286 (20130101) C08J 2201/026 (20130101) C08J 2205/022 (20130101) C08J 2205/024 (20130101) C08J 2207/00 (20130101) C08J 2333/10 (20130101) C08J 2333/14 (20130101) C08J 2335/02 (20130101)
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10675622 — Sample collection and transfer device

US 10675622	Lenigk et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Ralf Lenigk (Niskayuna, New York); Erin Jean Finehout (Clifton Park, New York); Xuefeng Wang (Niskayuna, New York)
ABSTRACT	An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.
FILED	Monday, February 26, 2018
APPL NO	15/905226
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/0258 (20130101) B01L 3/0262 (20130101) B01L 3/561 (20130101) B01L 3/5023 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 2200/10 (20130101) B01L 2200/027 (20130101) B01L 2300/12 (20130101) B01L 2300/069 (20130101) B01L 2300/161 (20130101) B01L 2300/165 (20130101) B01L 2300/0838 (20130101) B01L 2300/0887 (20130101) B01L 2400/0406 (20130101)
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10675841 — Thin diamond film bonding providing low vapor pressure at high temperature

US 10675841	Shaw et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary by the Navy (Washington, District of Columbia)
INVENTOR(S)	Jonathan L. Shaw (Springfield, Virginia); Jeremy Hanna (Fairfax, Virginia)
ABSTRACT	A thin diamond film bonded to a diamond substrate made by the process of heating a diamond substrate inside a vacuum chamber to about 500° C., cooling the diamond substrate, coating a first surface of the diamond substrate with chromium, depositing an initial layer of palladium, heating the diamond substrate, allowing the chromium and the diamond substrate to form a chemical bond, inter-diffusing the adhesion layer of chromium and the initial layer of palladium, cooling, depositing palladium, placing a shadow mask, degassing the vacuum, depositing a tin layer, assembling the tin layer, heating the tin layer, melting the tin layer, and bonding the thin diamond film to the diamond substrate. A thin diamond film bonded to a diamond substrate comprising a thin diamond film, a layer of chromium, palladium, tin, and a diamond substrate.
FILED	Wednesday, January 31, 2018
APPL NO	15/884783
ART UNIT	1784 — Miscellaneous Articles, Stock Material
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0016 (20130101) B23K 1/19 (20130101) B23K 2103/50 (20180801) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 9/04 (20130101) B32B 9/007 (20130101) Original (OR) Class B32B 9/041 (20130101) B32B 15/043 (20130101) B32B 37/04 (20130101) B32B 37/12 (20130101) B32B 37/24 (20130101) B32B 38/0036 (20130101) B32B 38/1858 (20130101) B32B 2037/243 (20130101) B32B 2037/246 (20130101) B32B 2038/0052 (20130101) B32B 2250/05 (20130101) B32B 2255/28 (20130101) B32B 2255/205 (20130101) B32B 2309/02 (20130101) B32B 2309/68 (20130101) B32B 2311/00 (20130101) B32B 2311/09 (20130101) B32B 2311/16 (20130101) B32B 2313/04 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 28/023 (20130101) C23C 30/00 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 1/34 (20130101) H01J 37/073 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/12542 (20150115)
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10676162 — Autonomous anchor device and methods using deployable blades

US 10676162	Roth et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)	United States Government as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Leif Roth (San Diego, California); Josh Bianchi (San Diego, California); Adam White (San Diego, California); Brian Daniel Shook (San Diego, California)
ABSTRACT	An autonomous anchor device, involving a streamlined body configured to freefall through a water column and to drive itself into sediment of an aquatic environment and a plurality of blades operably coupled with the streamlined body and configured to deploy itself into the sediment as well as retract itself from the sediment.
FILED	Tuesday, October 02, 2018
APPL NO	16/149230
ART UNIT	3617 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/26 (20130101) Original (OR) Class B63B 21/38 (20130101) B63B 2021/265 (20130101)
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10676168 — Breathing-air tank pressure tracking system

US 10676168	Wentworth et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	United States of America as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Brian C. Wentworth (Panama City, Florida); Dennis Gallagher (Panama City, Florida); Richard Manley (Panama City, Florida); William Hughes, III (Panama City, Florida); Bryan Le (Panama City Beach, Florida)
ABSTRACT	A breathing-air tank pressure tracking system includes a housing having lights mounted therein. The lights are spaced-apart from one another and disposed along a line. A pressure sensor is coupled to a tank containing pressurized breathing air. The pressure sensor detects a pressure of the pressurized breathing air and produces a signal indicative thereof. The housing is configured to be coupled to an exterior portion of a dive helmet wherein the lights are positioned in a field-of-view of a user wearing the dive helmet. A controller, mounted in the housing, is coupled to the pressure sensor and the lights. The controller activates selected ones of the lights based on the signal received from the pressure sensor.
FILED	Tuesday, April 30, 2019
APPL NO	16/399311
ART UNIT	2684 — Telemetry and Code Generation Vehicles and System Alarms
CURRENT CPC	Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 11/12 (20130101) Original (OR) Class B63C 2011/121 (20130101) Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 13/025 (20130101) F17C 2270/0781 (20130101)
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10676177 — Robotic landing gear for rotorcraft

US 10676177	Costello et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Earthly Dynamics, LLC (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S)	Mark F. Costello (Atlanta, Georgia); Michael Brian Ward (Atlanta, Georgia); R Matthew Tallent (McLean, Virginia); Ryan Hofmeister (Arlington, Virginia); Ashish Bagai (Vienna, Virginia)
ABSTRACT	The present invention relates to robotic landing gear for a rotorcraft that is designed to allow for landing on sloped and irregular surfaces. The robotic landing gear consists of articulated legs with contact sensors. Once the contact sensor touches a landing surface, the articulated leg in which contact is detected retracts to maintain a certain amount of contact pressure with the surface. Each articulated leg does this independently until contact is detected on the sensors of all of the robotic legs, at which point the legs lock in position and the rotorcraft can safely land.
FILED	Friday, May 27, 2016
APPL NO	15/166463
ART UNIT	3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 25/001 (20130101) Original (OR) Class B64C 25/32 (20130101) B64C 2025/008 (20130101) B64C 2025/325 (20130101)
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10676189 — Aircraft capture system and method

US 10676189	Lytle
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	LOCKHEED MARTIN CORPORATION (Bethesda, Maryland)
ASSIGNEE(S)	LOCKHEED MARTIN CORPORATION (Bethesda, Maryland)
INVENTOR(S)	William Benton Lytle (Littleton, Colorado)
ABSTRACT	An aircraft-to-aircraft retrieval system can be used to capture a remote aircraft for retrieval into and service by a transport aircraft during a flight mission. An aircraft capture device can be towed from the transport aircraft and brought into proximity with the remote aircraft during flight. A probe of the remote aircraft can be received within a receptacle of the aircraft capture device, and locking cables or locking arms of the aircraft capture device can be secured onto a portion of the probe. The aircraft capture device can be provided with an activation switch for detecting contact with the probe located in the receptacle and for transmitting an indication of the contact to initiate engagement of the probe. The aircraft capture device can be locked to the probe while it is reeled to the transport aircraft for retrieval of the remote aircraft.
FILED	Wednesday, February 01, 2017
APPL NO	15/422385
ART UNIT	3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 39/022 (20130101) B64C 39/024 (20130101) Original (OR) Class B64C 2201/182 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 3/00 (20130101) B64D 5/00 (20130101)
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10676409 — Energetic composites from metallized fluoropolymer melt-processed blends

US 10676409	Iacono et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S)	Scott Iacono (Colorado Springs, Colorado); Jena McCollum (Colorado Springs, Colorado)
ABSTRACT	An energetic composite comprises a metal powder; poly(vinylidene fluoride) (PVDF); and poly(lactic acid) (PLA). The metal powder comprises micrometer- or nanometer-sized particles, and the ratio of PVDF to PLA is between about 1:3 to 3:1. The metal powder comprises between about 4-32% wt of the energetic composite, and the metal powder consists of aluminum (Al), magnesium (Mg), or boron (B). A method of making an energetic composite material, comprises melt-blending a metal powder with poly(vinylidene fluoride) (PVDF) and poly(lactic acid) (PLA).
FILED	Friday, March 31, 2017
APPL NO	15/475183
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 67/0055 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2027/16 (20130101) B29K 2067/046 (20130101) B29K 2105/16 (20130101) B29K 2505/02 (20130101) B29K 2507/02 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0025 (20130101) Original (OR) Class C06B 23/00 (20130101)
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10676445 — Synthesis of aminopyrimidine-based energetic materials

US 10676445	Wilhelm et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as Represented by the Secretary of the Navy (Indian Head, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Christopher Wilhelm (Port Tobacco, Maryland); Farhad Forohar (LaPlata, Maryland); Denisse Soto (Alexandria, Virginia)
ABSTRACT	A new azido compound, 5-amino-6-chloro-2,4-diazido-pyrimidine, and a process for synthesizing. The synthesis may include reacting 5-amino-2,4,6-trichloropyrimidine and sodium azide. There is an excess molar amount of sodium azide for each chloro fractional molar amount on the 5-amino-2,4,6-trichloropyrimidine. The synthesis is a two phase reaction that is a dispersion. The 5-amino-2,4,6-trichloropyrimidine dissolved in acetone is a liquid phase, and the sodium azide is insoluble in acetone and is a solid phase, that is present in excess of chemical equivalents. The reaction product is soluble in acetone, and the reaction by-product, sodium chloride is also insoluble in acetone, and the crude yield is about 92%. Unreacted sodium azide and formed sodium chloride are removed by filtration.
FILED	Thursday, June 06, 2019
APPL NO	16/501761
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 239/48 (20130101) Original (OR) Class C07D 239/50 (20130101)
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10676629 — Methods for preparation of concentrated graphene ink compositions and related composite materials

US 10676629	Hersam et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Mark C. Hersam (Wilmette, Illinois); Yu Teng Liang (Chicago, Illinois); Ethan B. Secor (Evanston, Illinois); Pradyumna L. Prabhumirashi (Chicago, Illinois); Kanan P. Puntambekar (Chicago, Illinois); Michael L. Geier (Chicago, Illinois)
ABSTRACT	A rapid, scalable methodology for graphene dispersion and concentration with a polymer-organic solvent medium, as can be utilized without centrifugation, to enhance graphene concentration.
FILED	Monday, December 04, 2017
APPL NO	15/830508
ART UNIT	1764 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/14 (20130101) C09D 11/38 (20130101) Original (OR) Class C09D 11/52 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/24 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/31721 (20150401) Y10T 428/31786 (20150401)
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10676721 — Bacteriophages expressing antimicrobial peptides and uses thereof

US 10676721	Collins et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD)
APPLICANT(S)	James J. Collins (Newton, Massachusetts); Michael Koeris (Natick, Massachusetts); Timothy Kuan-Ta Lu (Charlestown, Massachusetts); Gregory Stephanopoulos (Winchester, Massachusetts); Christopher Jongsoo Yoon (Seoul, South Korea)
ASSIGNEE(S)	Trustees of Boston University (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	James J. Collins (Newton, Massachusetts); Michael Koeris (Natick, Massachusetts); Timothy Kuan-Ta Lu (Charlestown, Massachusetts); Tanguy My Chau (Palo Alto, California); Gregory Stephanopoulos (Winchester, Massachusetts); Christopher Jongsoo Yoon (Seoul, South Korea)
ABSTRACT	The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enzymes or fragments thereof for targeting a broad spectrum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some embodiments, bacteriophages express antimicrobial peptides or antimicrobial polypeptides (e.g. phage lytic enzymes) which are secreted from the host bacteria, or alternatively released upon lysis of the bacterial host cell. Aspects of the present invention also relate to the use of the engineered bacteriophages for the reduction of bacterial infections, both in a subject or for bioremediation purposes, in clinical settings and wound healing.
FILED	Friday, September 02, 2011
APPL NO	13/224776
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 38/1767 (20130101) Peptides C07K 14/463 (20130101) C07K 14/43504 (20130101) C07K 14/43563 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 9/503 (20130101) C12N 2795/10221 (20130101) C12N 2795/10231 (20130101) C12N 2795/10232 (20130101) C12N 2795/12032 (20130101) C12N 2795/12043 (20130101) C12N 2795/14132 (20130101) C12N 2795/14143 (20130101)
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10676814 — System and method for controlling the elemental composition of films produced by pulsed laser deposition

US 10676814	McGinnis et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)
INVENTOR(S)	Wayne C. McGinnis (San Diego, California); Alexandru Hening (San Diego, California); Teresa Emery-Adleman (San Diego, California)
ABSTRACT	A pulsed laser deposition system comprising a split ablation target having a first half and a second half, wherein the target contains a film material for deposition on a substrate, and wherein the film material is comprised of a plurality of component elements, the elements varying in volatility, and wherein one half of the split ablation target contains more of the most volatile elements being deposited than the other half, and wherein the split ablation target is rotated about its center. A laser beam is rastered back and forth across the target such that the laser spends more time on one half of the split target than the other half depending on the elemental volatility. The target rotation and laser beam rastering are coordinated simultaneously to vary the elemental composition of the resulting film deposition.
FILED	Thursday, September 28, 2017
APPL NO	15/718202
ART UNIT	1718 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/08 (20130101) C23C 14/28 (20130101) C23C 14/505 (20130101) Original (OR) Class
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10677069 — Component core with shaped edges

US 10677069	Devore et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmngton, Connecticut)
INVENTOR(S)	Matthew A. Devore (Cromwell, Connecticut); Matthew S. Gleiner (Norwalk, Connecticut); Douglas C. Jenne (Ashford, Connecticut)
ABSTRACT	A gas turbine engine according to an example of the present disclosure includes, among other things, a plurality of blade outer air seals and a plurality of airfoils, at least one of seals and airfoils including at least one cooling passage. The cooling passage includes a first wall and an opposed second wall bounding the cooling passage, a surface contour of the first wall having a plurality of first surface features and a surface contour of the second wall having a plurality of second surface features. The first surface features and the second surface features are arranged such that a width of the cooling passage varies along a length of the cooling passage defined by the first surface features and the second surface features. The first surface features have a first profile, and the second surface features have a second, different profile. A casting core for forming cooling passages in an aircraft component is also disclosed.
FILED	Monday, November 26, 2018
APPL NO	16/199825
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Foundry Moulding B22C 9/10 (20130101) B22C 9/106 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/186 (20130101) Original (OR) Class F01D 5/187 (20130101) F01D 9/041 (20130101) F01D 11/08 (20130101) F01D 25/12 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/211 (20130101) F05D 2240/12 (20130101) F05D 2240/30 (20130101) F05D 2240/55 (20130101) F05D 2240/81 (20130101) F05D 2240/126 (20130101) F05D 2260/202 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/676 (20130101)
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10677084 — Turbine tip shroud assembly with plural shroud segments having inter-segment seal arrangement

US 10677084	Smoke et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
ASSIGNEE(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
INVENTOR(S)	Jason Smoke (Phoenix, Arizona); Kent L. Kime (Phoenix, Arizona); Blake Petersen (Scottsdale, Arizona); Luke Zurmehly (Phoenix, Arizona)
ABSTRACT	A shroud assembly for a gas turbine engine includes a plurality of shroud segments that are attached to a shroud support with an inter-segment joint defined between shroud segments. The shroud assembly also includes a cooling flow path cooperatively defined by the shroud support and the first shroud segment. The cooling flow path includes an internal cooling passage within the shroud segments. The cooling flow path includes an outlet chamber configured to receive flow from the internal cooling passage. The shroud assembly additionally includes a seal arrangement that extends across the inter-segment joint. The seal arrangement, the first shroud segment, and the second shroud segment cooperatively define a seal chamber that is enclosed.
FILED	Tuesday, February 20, 2018
APPL NO	15/899756
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/04 (20130101) F01D 11/005 (20130101) F01D 11/08 (20130101) Original (OR) Class F01D 11/122 (20130101) F01D 25/12 (20130101) F01D 25/246 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/11 (20130101) F05D 2240/55 (20130101) F05D 2240/56 (20130101) F05D 2260/201 (20130101) F05D 2260/204 (20130101)
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10677161 — Gas turbine engine diffuser cooling and mixing arrangement

US 10677161	Lyons et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Christopher B. Lyons (West Hartford, Connecticut); Albert K. Cheung (East Hampton, Connecticut)
ABSTRACT	A diffuser for a gas turbine engine includes a diffuser housing that has a circumferential array of hollow struts that provide a cavity. The diffuser housing includes inlet and outlet apertures that are in fluid communication with the cavity. An opening on a trailing end of the struts is in fluid communication with the cavity. The diffuser housing is configured to introduce a fluid through the inlet aperture and receive a core flow through the opening. The fluid and core flow exit through the outlet aperture.
FILED	Friday, July 18, 2014
APPL NO	14/913922
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/081 (20130101) F01D 5/082 (20130101) F01D 9/065 (20130101) F01D 25/125 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 6/06 (20130101) F02C 6/08 (20130101) Original (OR) Class F02C 7/185 (20130101) Non-positive-displacement Pumps F04D 29/542 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/3219 (20130101) F05D 2240/122 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/676 (20130101)
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10677567 — Shockwave controlled ballistic protection

US 10677567	Villalobos et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Guillermo R. Villalobos (Springfield, Virginia); Shyam S. Bayya (Ashburn, Virginia); Woohong Kim (Washington, District of Columbia); Bryan Sadowski (Falls Church, Virginia); Michael Hunt (Alexandria, Virginia); Robert E. Miklos (La Plata, Maryland); Colin C. Baker (Alexandria, Virginia); Jasbinder S. Sanghera (Ashburn, Virginia); Alex E. Moser (Washington, District of Columbia)
ABSTRACT	A transparent composite armor is made of tens to hundreds or even thousands of thin layers of material each with a thickness of 10-500 μm. An appropriate amount of impedance mismatch between the layers causes some reflection at each interface but limit the amplitude of the resulting tensile wave below the tensile strength of the constituent materials. The result is an improvement in ballistic performance and that will result is a significant impact in reducing size, weight, and volume of the armor.
FILED	Wednesday, April 26, 2017
APPL NO	15/497948
ART UNIT	1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/02 (20130101) B32B 7/04 (20130101) B32B 15/04 (20130101) B32B 15/20 (20130101) B32B 27/08 (20130101) B32B 27/32 (20130101) B32B 27/34 (20130101) B32B 27/36 (20130101) B32B 27/38 (20130101) B32B 27/40 (20130101) B32B 27/281 (20130101) B32B 27/285 (20130101) B32B 27/286 (20130101) B32B 27/288 (20130101) B32B 27/302 (20130101) B32B 27/304 (20130101) B32B 27/308 (20130101) B32B 27/365 (20130101) B32B 37/14 (20130101) B32B 2250/03 (20130101) B32B 2250/24 (20130101) B32B 2250/42 (20130101) B32B 2307/54 (20130101) B32B 2307/412 (20130101) B32B 2307/558 (20130101) B32B 2307/732 (20130101) B32B 2309/105 (20130101) B32B 2311/18 (20130101) B32B 2311/24 (20130101) B32B 2333/12 (20130101) B32B 2375/00 (20130101) B32B 2457/00 (20130101) B32B 2571/02 (20130101) B32B 2605/006 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/0407 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 428/24331 (20150115) Y10T 428/24545 (20150115) Y10T 428/24802 (20150115) Y10T 428/24917 (20150115) Y10T 428/24967 (20150115)
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10677576 — Multistage thermal trigger

US 10677576	Hansen et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Systima Technologies, Inc. (Kirkland, Washington)
ASSIGNEE(S)	Systima Technologies, Inc. (Kirkland, Washington)
INVENTOR(S)	Stephanie J Hansen (Woodinville, Washington); Keith Krasnowski (Lynnwood, Washington); Peter J Golden (Seattle, Washington)
ABSTRACT	Multistage thermal trigger devices disclosed herein may include a first stage and a second stage, wherein the first stage activates at a first temperature, and wherein the second stage activates at a second temperature. The first stage activates an arming assembly so that the second stage is armed. The second stage may then activate the output of the multistage thermal trigger device, via the arming assembly, when the second temperature is reached. An autoignition material (AIM) capsule is also disclosed herein. The AIM capsule may be deployed in connection with the disclosed multistage thermal trigger devices.
FILED	Tuesday, December 27, 2016
APPL NO	15/391418
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 39/20 (20130101) Ammunition Fuzes; Arming or Safety Means Therefor F42C 15/36 (20130101) Original (OR) Class F42C 15/188 (20130101)
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10677722 — Photothermal imaging device and system

US 10677722	Li et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Notre Dame du Lac (South Bend, Indiana)
ASSIGNEE(S)	University of Notre Dame du Lac (South Bend, Indiana)
INVENTOR(S)	Zhongming Li (Notre Dame, Indiana); Gregory Hartland (Granger, Indiana); Masaru Ken Kuno (Notre Dame, Indiana)
ABSTRACT	Mid-infrared photothermal heterodyne imaging (MIR-PHI) techniques described herein overcome the diffraction limit of traditional MIR imaging and uses visible photodiodes as detectors. MIR-PHI experiments are shown that achieve high sensitivity, sub-diffraction limit spatial resolution, and high acquisition speed. Sensitive, affordable, and widely applicable, photothermal imaging techniques described herein can serve as a useful imaging tool for biological systems and other submicron-scale applications.
FILED	Wednesday, April 05, 2017
APPL NO	15/480218
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/35 (20130101) G01N 21/171 (20130101) G01N 21/3563 (20130101) Original (OR) Class G01N 2021/1712 (20130101) G01N 2021/1714 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/02 (20130101) G01Q 60/34 (20130101)
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10677756 — Integrated sensor cartridge system and method of use

US 10677756	Goldfine et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	JENTEK Sensors, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	JENTEK SENSORS, INC. (Waltham, Massachusetts)
INVENTOR(S)	Neil J Goldfine (Indian Harbour Beach, Florida); Yanko K Sheiretov (Waltham, Massachusetts); Scott A Denenberg (Boston, Massachusetts); Karen Walrath (Waltham, Massachusetts); Todd M Dunford (Amherst, Massachusetts); Kevin P Dixon (Boston, Massachusetts); Christopher T Martin (Concord, Massachusetts)
ABSTRACT	A sensor system has an integrated sensor cartridge, and instrument, and an instrument side connector. The integrated sensor cartridge has a mechanical support, a flexible sensor array, and a rigid connector. The mechanical support is shaped to facilitate sensor measurements on a test object. The rigid connector has a mechanical connection and an electrical connection for simultaneous electrical and mechanical mating of the sensor cartridge to the instrument side connector. The flexible array has a connecting portion, a lead portion, and a sensing portion. The sensing portion is attached to the mechanical support, and the connecting portion interfaces with the rigid connector. The connecting portion may form the electrical connection of the rigid connector or may simply mate internally with the electrical connection. The instrument side connector is connected to the instrument which measures the response of the flexible sensor array. Test objects may include bolt holes, fillets, disk slots, and other types of parts or components.
FILED	Tuesday, May 31, 2016
APPL NO	15/169361
ART UNIT	2867 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/904 (20130101) Original (OR) Class G01N 27/9006 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 27/2635 (20130101) G01R 33/0047 (20130101) G01R 33/0094 (20130101)
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10677891 — Systems and methods for wave sensing and ship motion forecasting using multiple radars

US 10677891	Rudzinsky et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Applied Physical Sciences Corp. (Groton, Connecticut)
ASSIGNEE(S)	Applied Physical Sciences Corp. (Groton, Connecticut)
INVENTOR(S)	Jason P. Rudzinsky (Groton, Connecticut); John G. Kusters, Jr. (Groton, Connecticut); Benjamin S. H. Connell (Groton, Connecticut); Christopher S. Brundick (Groton, Connecticut); Kevin Cockrell (Groton, Connecticut); William M. Milewski (Groton, Connecticut)
ABSTRACT	Ship motion forecasting systems and methods are described herein that can enable accurate real-time forecasting of ocean waves and resultant ship motions. Such systems and methods can be used to improve the efficiency and safety of a variety of ship operations, including the moving of cargo between ships at sea. In general, the systems and methods transmit radar signals from multiple radars, and those radar signals from the multiple radars are reflected off the surface of a body of water. The reflected radar signals are received, and radar data is generated from the received radar signals. The radar data is used to generate ocean wave components, which represent the amplitude and phase of a multitude of individual waves that together can describe the surface of the ocean. These ocean wave components are then used generate ship motion forecasts, which can then be presented to one or more users.
FILED	Thursday, September 14, 2017
APPL NO	15/704906
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Ships or Other Waterborne Vessels; Equipment for Shipping B63B 39/14 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/04 (20130101) G01S 7/24 (20130101) Original (OR) Class G01S 13/50 (20130101) G01S 13/62 (20130101) G01S 13/86 (20130101) G01S 13/91 (20130101) G01S 13/605 (20130101) G01S 13/874 (20130101) G01S 13/937 (20200101)
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10678206 — Remote feature measurement

US 10678206	Quitter et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	UNITED TECHNOLOGIES CORPORATION (Hartford, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	John Quitter (Farmington, Connecticut); Joseph D. Drescher (Middletown, Connecticut)
ABSTRACT	A system includes a laser-line imaging subsystem to measure a feature. The laser-line imaging subsystem includes a laser to project a laser-line, and a digital video camera mounted at an angle with respect to an axis of said laser to obtain an optical image of the laser-line. A control subsystem is operable to compute three-dimensional coordinate points via triangulation of an intersection between the laser-line and the optical image of the laser-line, the three-dimensional coordinate points data used by the control subsystem to calculate predictive airflow through the workpiece with respect to the volume of the machined holes.
FILED	Friday, November 08, 2013
APPL NO	14/759497
ART UNIT	2119 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/032 (20130101) B23K 26/382 (20151001) B23K 26/389 (20151001) B23K 2101/001 (20180801) Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 2700/06 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/182 (20130101) Original (OR) Class G05B 2219/37281 (20130101) G05B 2219/45139 (20130101)
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10678505 — Subset encoding method: increasing pattern density for finite automata

US 10678505	Guo
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia)
ASSIGNEE(S)	UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia)
INVENTOR(S)	Deyuan Guo (Charlottesville, Virginia)
ABSTRACT	The subset encoding method and related automata designs for improving the space efficiency for many applications on the Automata Processor (AP) are presented. The method is a general method that can take advantage of the character-or ability of STEs (State Transition Elements) on the AP, and can relieve the problems of limited hardware capacity and inefficient routing. Experimental results show that after applying the subset encoding method on Hamming distance automata, up to 3.2× more patterns can be placed on the AP if a sliding window is required. If a sliding window is not required, up to 192× more patterns can be placed on the AP. For a Levenshtein distance, the subset encoding can split the Levenshtein automata into small chunks and make them routable on the AP. The impact of the subset encoding method depends on the character size of the AP.
FILED	Thursday, December 31, 2015
APPL NO	14/986131
ART UNIT	2122 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 5/01 (20130101) Original (OR) Class G06F 7/00 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 99/00 (20190201)
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10678666 — Method and system for implementing automated test and retest procedures in a virtual test environment

US 10678666	Gauf et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Innovative Defense Technologies, LLC (Arlington, Virginia)
ASSIGNEE(S)	INNOVATIVE DEFENSE TECHNOLOGIES, LLC (Arlington, Virginia)
INVENTOR(S)	Bernard Gauf (Vienna, Virginia); Elfriede Dustin (Springfield, Virginia); David Zwacki (New Bedford, Massachusetts)
ABSTRACT	According to an embodiment of the present invention, a computer implemented method and system for automated test and retesting in a virtual test environment, comprises: an input interface, comprising at least one processor, configured to receive one or more commands from a user, wherein the one or more commands comprise at least one test procedure and at least one system version parameter; a test and retest engine, comprising at least one processor, configured to execute the one or more commands on at least one system under test on a virtual environment based at least in part on the at least one system version parameter; and an output interface, comprising at least one processor, configured to receive results data responsive to execution of the one or more commands and further configured to display the results to the user.
FILED	Tuesday, December 18, 2012
APPL NO	13/718295
ART UNIT	2865 — Printing/Measuring and Testing
CURRENT CPC	Electric Digital Data Processing G06F 11/2635 (20130101) Original (OR) Class G06F 11/3688 (20130101)
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10678724 — Apparatuses, methods, and systems for in-network storage in a configurable spatial accelerator

US 10678724	ChoFleming et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)	Intel Corporation (Santa Clara, California)
INVENTOR(S)	Kermin ChoFleming (Hudson, Massachusetts); Simon Steely, Jr. (Hudson, New Hampshire); Kent Glossop (Nashua, New Hampshire)
ABSTRACT	Systems, methods, and apparatuses relating to in-network storage for a configurable spatial accelerator are described. In one embodiment, a configurable spatial accelerator includes a plurality of processing elements; a circuit switched interconnect network between the plurality of processing elements to receive an input of a dataflow graph comprising a plurality of nodes, wherein the dataflow graph is to be overlaid into the circuit switched interconnect network and the plurality of processing elements with each node represented as a dataflow operator in the plurality of processing elements, and the plurality of processing elements are to perform an operation by a respective, incoming operand set arriving at each of the dataflow operators of the plurality of processing elements; and an in-network storage element of the circuit switched interconnect network comprising a queue coupled to an output queue of a first processing element, and a controller that switches the in-network storage element into a first mode that provides a value stored in the queue of the in-network storage element by the output queue of the first processing element to an input queue of a second processing element when a configuration value is a first value, and into a second mode that bypasses the queue of the in-network storage element and provides a value from the output queue of the first processing element to the input queue of the second processing element when the configuration value is a second value.
FILED	Saturday, December 29, 2018
APPL NO	16/236423
ART UNIT	2184 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 13/24 (20130101) Original (OR) Class G06F 2213/24 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 49/15 (20130101) H04L 67/1097 (20130101)
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10678741 — Coupling parallel event-driven computation with serial computation

US 10678741	Jackson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Bryan L. Jackson (Fremont, California); Dharmendra S. Modha (San Jose, California); Norman J. Pass (Sunnyvale, California)
ABSTRACT	The present invention provides a system comprising a neurosynaptic processing device including multiple neurosynaptic core circuits for parallel processing, and a serial processing device including at least one processor core for serial processing. Each neurosynaptic core circuit comprises multiple electronic neurons interconnected with multiple electronic axons via a plurality of synapse devices. The system further comprises an interconnect circuit for coupling the neurosynaptic processing device with the serial processing device. The interconnect circuit enables the exchange of data packets between the neurosynaptic processing device and the serial processing device.
FILED	Tuesday, May 24, 2016
APPL NO	15/163563
ART UNIT	2121 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 13/4221 (20130101) Original (OR) Class G06F 13/4282 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/063 (20130101)
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10679007 — Method and system for pattern discovery and real-time anomaly detection based on knowledge graph

US 10679007	Jia et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Intelligent Fusion Technology, Inc (Germantown, Maryland)
ASSIGNEE(S)	INTELLIGENT FUSION TECHNOLOGY, INC. (Germantown, Maryland)
INVENTOR(S)	Bin Jia (Germantown, Maryland); Cailing Dong (Germantown, Maryland); Zhijiang Chen (Germantown, Maryland); Kuo-Chu Chang (Fairfax, Virginia); Nichole Sullivan (Germantown, Maryland); Genshe Chen (Germantown, Maryland)
ABSTRACT	A method for pattern discovery and real-time anomaly detection based on knowledge graph, comprising: based on a dataset including messages collected within a certain period, constructing a local knowledge graph (KG); applying a statistical relational learning (SRL) model to predict hidden relations between entities to obtain an updated local KG; from all SPO triples of the updated local KG, discovering a normalcy pattern that includes frequent entities, frequent relations, and frequent SPO triples; and in response to receiving streaming data from a message bus, extracting a plurality of entities, a plurality of relations, and a plurality of SPO triples, from the streaming data for comparison with the normalcy pattern using semantic distance, thereby determining whether there is an abnormal entity, relation, or SPO triple in the streaming data.
FILED	Thursday, August 30, 2018
APPL NO	16/117964
ART UNIT	2672 — Facsimile; Printer; Color; halftone; Scanner; Computer Graphic Processing; 3-D Animation; Display Color; Attributes; Object Processing; Hardware and Memory
CURRENT CPC	Electric Digital Data Processing G06F 16/288 (20190101) G06F 40/30 (20200101) G06F 40/253 (20200101) G06F 40/268 (20200101) G06F 40/295 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/047 (20130101)
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10679063 — Recognizing salient video events through learning-based multimodal analysis of visual features and audio-based analytics

US 10679063	Cheng et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of the Interior (DOI)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)	SRI International (Menlo Park, California)
INVENTOR(S)	Hui Cheng (Bridgewater, New Jersey); Ajay Divakaran (Monmouth Junction, New Jersey); Elizabeth Shriberg (Menlo Park, California); Harpreet Singh Sawhney (Princeton, New Jersey); Jingen Liu (Plainsboro, New Jersey); Ishani Chakraborty (Franklin Park, New Jersey); Omar Javed (Franklin Park, New Jersey); David Chisolm (Menlo Park, California); Behjat Siddiquie (Plainsboro, New Jersey); Steven S. Weiner (Merion Station, Pennsylvania)
ABSTRACT	A computing system for recognizing salient events depicted in a video utilizes learning algorithms to detect audio and visual features of the video. The computing system identifies one or more salient events depicted in the video based on the audio and visual features.
FILED	Friday, September 04, 2015
APPL NO	14/846318
ART UNIT	2424 — Cable and Television
CURRENT CPC	Electric Digital Data Processing G06F 16/43 (20190101) G06F 16/78 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00718 (20130101) Original (OR) Class Information Storage Based on Relative Movement Between Record Carrier and Transducer G11B 27/10 (20130101) G11B 27/031 (20130101) Pictorial Communication, e.g Television H04N 21/233 (20130101) H04N 21/4394 (20130101) H04N 21/8549 (20130101) H04N 21/23418 (20130101) H04N 21/44008 (20130101) H04N 21/44029 (20130101)
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10679120 — Power driven synaptic network synthesis

US 10679120	Alpert et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Charles J. Alpert (Austin, Texas); Pallab Datta (San Jose, California); Myron D. Flickner (San Jose, California); Zhuo Li (Cedar Park, Texas); Dharmendra S. Modha (San Jose, California); Gi-Joon Nam (Austin, Texas)
ABSTRACT	Embodiments of the present invention relate to providing power minimization in a multi-core neurosynaptic network. In one embodiment of the present invention, a method of and computer program product for power-driven synaptic network synthesis is provided. Power consumption of a neurosynaptic network is modeled as wire length. The neurosynaptic network comprises a plurality of neurosynaptic cores. An arrangement of the synaptic cores is determined by minimizing the wire length.
FILED	Monday, November 10, 2014
APPL NO	14/537826
ART UNIT	2123 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 30/327 (20200101) G06F 2119/06 (20200101) Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) G06N 3/063 (20130101) Original (OR) Class
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10679407 — Methods, systems, and computer readable media for modeling interactive diffuse reflections and higher-order diffraction in virtual environment scenes

US 10679407	Schissler et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S)	Carl Henry Schissler (Carrboro, North Carolina); Ravish Mehra (Chapel Hill, North Carolina); Dinesh Manocha (Chapel Hill, North Carolina)
ABSTRACT	Methods, systems, and computer readable media for simulating sound propagation are disclosed. According to one method, the method includes decomposing a virtual environment scene including at least one object into a plurality of surface regions, wherein each of the surface regions includes a plurality of surface patches. The method further includes organizing sound rays generated by a sound source in the virtual environment scene into a plurality of path tracing groups, wherein each of the path tracing groups comprises a group of the rays that traverses a sequence of surface patches. The method also includes determining, for each of the path tracing groups, a sound intensity by combining a sound intensity computed for a current time with one or more previously computed sound intensities respectively associated with previous times and generating a simulated output sound at a listener position using the determined sound intensities.
FILED	Monday, June 29, 2015
APPL NO	14/754155
ART UNIT	2654 — Audio Signals
CURRENT CPC	Image Data Processing or Generation, in General G06T 15/06 (20130101) G06T 17/20 (20130101) Original (OR) Class Stereophonic Systems H04S 7/30 (20130101)
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10679730 — Prognostic and predictive breast cancer signature

US 10679730	Rosner et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD)
APPLICANT(S)	The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)	The University of Chicago (Chicago, Illinois)
INVENTOR(S)	Marsha Rosner (Chicago, Illinois); Miao Sun (Chicago, Illinois); Unjin Lee (Chicago, Illinois)
ABSTRACT	Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating a specified set of genes. Specifically, methods may comprise calculating a prognosis score based on a particular algorithm. Also disclosed are compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more upstream activators and/or downstream effectors of TET1.
FILED	Wednesday, November 25, 2015
APPL NO	14/952265
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/167 (20130101) A61K 31/405 (20130101) A61K 31/506 (20130101) A61K 31/706 (20130101) A61K 31/7068 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) G01N 2800/52 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) Original (OR) Class
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10680088 — Tunnel field effect transistor having anisotropic effective mass channel

US 10680088	Ilatikhameneh et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Hesameddin Ilatikhameneh (Waukegan, Illinois); Tarek Ameen Beshari (West Lafayette, Indiana); Bozidar Novakovic (West Lafayette, Indiana); Gerhard Klimeck (West Lafayette, Indiana); Rajib Rahman (West Lafayette, Indiana)
ABSTRACT	A tunnel field effect transistor (TFET) device includes a substrate, heavily doped source and drain regions disposed at opposite ends of a channel region forming a PiN or NiP structure, the channel region including a first substantially parallelogram portion having a first length defined along a longitudinal axis extending from the source region to the drain region and a second substantially parallelogram portion having a second length defined along the longitudinal axis larger than the first length, the TFET device having an effective channel length that is an average of the first and second lengths. The channel region includes a channel material with a first effective mass along a longitudinal axis extending from the source region to the drain region and a second effective mass along a lateral axis perpendicular to the longitudinal axis, the first effective mass being greater than the second effective mass.
FILED	Tuesday, November 27, 2018
APPL NO	16/201960
ART UNIT	2897 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/267 (20130101) H01L 29/0834 (20130101) H01L 29/0847 (20130101) H01L 29/1025 (20130101) H01L 29/1033 (20130101) H01L 29/7391 (20130101) Original (OR) Class H01L 29/42312 (20130101)
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10680132 — Non-destructive wafer recycling for epitaxial lift-off thin-film device using a superlattice epitaxial layer

US 10680132	Forrest et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Stephen R. Forrest (Ann Arbor, Michigan); Kyusang Lee (Ann Arbor, Michigan); Dejiu Fan (Ann Arbor, Michigan)
ABSTRACT	The present disclosure relates to methods and growth structures for making thin-film electronic and optoelectronic devices, such as flexible photovoltaic devices, using epitaxial lift-off (ELO). In particular, disclosed herein are wafer protection schemes that preserve the integrity of the wafer surface during ELO and increase the number of times that the wafer may be used for regrowth. The wafer protection schemes use growth structures that include at least one superlattice layer.
FILED	Thursday, January 15, 2015
APPL NO	15/111218
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0687 (20130101) H01L 31/0693 (20130101) H01L 31/0735 (20130101) H01L 31/1844 (20130101) H01L 31/1892 (20130101) H01L 31/1896 (20130101) Original (OR) Class H01L 31/03046 (20130101) H01L 31/035236 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/544 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/521 (20151101)
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10680152 — Passive thermal oscillators

US 10680152	Taylor et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Patrick J. Taylor (Vienna, Virginia); Jay Maddux (Greenbelt, Maryland); Adam A. Wilson (Columbia, Maryland)
ABSTRACT	A passive thermal oscillator combines a thermoelectric device and a passive analog electrical circuit to produce a time-oscillating temperature difference. The oscillator makes use of a temperature difference imposed across a thermoelectric device to produce a Seebeck voltage to periodically trigger electrical current to pass through a switch. The periodic electrical current causes periodic Peltier cooling producing a time-oscillating temperature difference across the thermoelectric device. There is no requirement for additional external energy input because the thermal energy generates a voltage that is used as the driving force. The operation is purely passive. So long as there is a temperature difference across the thermoelectric device, then the passive thermal oscillator oscillates. The passive thermal oscillator can integrate multiple energy conversion device technologies to operate cooperatively. The cooperation of multiple energy conversion technologies yields a much higher overall system efficiency than just the conversion of thermal energy into electrical energy.
FILED	Monday, December 17, 2018
APPL NO	16/222773
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/28 (20130101) Original (OR) Class H01L 37/02 (20130101) H01L 37/04 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 1/02 (20130101)
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10680193 — Photoelectric cells incorporating wrinkles and folds to enhance efficiency and bendability and method of making

US 10680193	Loo et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Yueh-Lin Loo (Princeton, New Jersey); Jongbok Kim (Princeton, New Jersey); Pilnam Kim (Daejeon, South Korea); Howard Stone (Princeton, New Jersey); Nicolas Pegard (Princeton, New Jersey); Jason Fleischer (Princeton, New Jersey)
ASSIGNEE(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
INVENTOR(S)	Yueh-Lin Loo (Princeton, New Jersey); Jongbok Kim (Princeton, New Jersey); Pilnam Kim (Daejeon, South Korea); Howard Stone (Princeton, New Jersey); Nicolas Pegard (Princeton, New Jersey); Jason Fleischer (Princeton, New Jersey)
ABSTRACT	A photovoltaic cell and method of making are disclosed. The photovoltaic cell includes a substrate having a surface at least partially covered in wrinkles and folds, the folds dividing the surface into a plurality of domains. A photoactive layer is formed on the substrate. At least one transparent electrode is coupled to the photoactive layer and configured to allow transmission of light into the photoactive layer. The domains may have a wrinkle periodicity of less than 2 μm. The folds may have a fold density of less than 0.25. The transport layer may comprise PEDOT:PSS. The photoactive layer may comprise P3HT:PCBM. The photoactive layer may comprise a bulk heterojunction.
FILED	Friday, March 14, 2014
APPL NO	14/214564
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0037 (20130101) H01L 51/0097 (20130101) H01L 51/447 (20130101) Original (OR) Class H01L 51/4253 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101)
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10680340 — Cone-based multi-layer wide band antenna

US 10680340	Lin et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA)
APPLICANT(S)	Intelligent Fusion Technology, Inc (Germantown, Maryland)
ASSIGNEE(S)	INTELLIGENT FUSION TECHNOLOGY, INC. (Germantown, None)
INVENTOR(S)	Xingping Lin (Germantown, Maryland); Zhonghai Wang (Germantown, Maryland); Genshe Chen (Germantown, Maryland); Erik Blasch (Arlington, Virginia); Khanh Pham (Kirtland AFB, New Mexico)
ABSTRACT	A cone-based multi-layer wide band antenna is provided, including a cone-based member having a multi-layer structure. The multi-layer structure includes a first layer conical structure, and the first layer conical structure has a height and a base radius configured to provide a desired impedance of the antenna.
FILED	Friday, May 18, 2018
APPL NO	15/983266
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/36 (20130101) H01Q 1/38 (20130101) H01Q 5/357 (20150115) H01Q 5/378 (20150115) H01Q 9/28 (20130101) Original (OR) Class H01Q 9/40 (20130101) H01Q 9/46 (20130101)
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10680413 — Method for high-concentration doping of germanium with phosphorous

US 10680413	Bessette et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Navy (DON) Naval Air Systems Command (NAVAIR) Naval Air Warfare Center Aircraft Division (NAWCAD) Naval Air Warfare Center (NAWC)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Jonathan T. Bessette (Essex Junction, Vermont); Yan Cai (Cambridge, Massachusetts); Rodolfo E. Camacho-Aguilera (Cambridge, Massachusetts); Jifeng Liu (Hanover, New Hampshire); Lionel Kimerling (Concord, Massachusetts); Jurgen Michel (Arlington, Massachusetts)
ABSTRACT	In a method for electrically doping a semiconducting material, a layer of germanium is formed having a germanium layer thickness, while in situ incorporating phosphorus dopant atoms at a concentration of at least about 5×10¹⁸cm⁻³through the thickness of the germanium layer during formation of the germanium layer. Additional phosphorus dopant atoms are ex situ incorporated through the thickness of the germanium layer, after formation of the germanium layer, to produce through the germanium layer thickness a total phosphorus dopant concentration of at least about 2×10¹⁹cm⁻³.
FILED	Monday, May 01, 2017
APPL NO	15/582938
ART UNIT	2826 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0237 (20130101) H01L 21/0245 (20130101) H01L 21/0262 (20130101) H01L 21/2254 (20130101) H01L 21/02532 (20130101) H01L 21/02576 (20130101) H01L 21/02661 (20130101) H01L 21/02664 (20130101) H01L 21/26513 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/227 (20130101) H01S 5/0421 (20130101) H01S 5/0422 (20130101) H01S 5/2214 (20130101) H01S 5/3027 (20130101) Original (OR) Class H01S 5/3054 (20130101) H01S 5/3086 (20130101) H01S 5/3223 (20130101)
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10680581 — RF signal switching, phase shifting and polarization control

US 10680581	Valdes Garcia et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Alberto Valdes Garcia (Chappaqua, New York); Wayne H. Woods, Jr. (Burlington, Massachusetts); Bodhisatwa Sadhu (Fishkill, New York)
ABSTRACT	An apparatus includes first and second electronically tunable transmission lines configured to transmit or receive a signal pair and provide a selected phase delay difference to the signal pair corresponding to a selected polarization, a first attenuation element connected to the first electronically tunable transmission line and a second attenuation element connected to the second electronically tunable transmission line. The first and second attenuation elements may each be configured to selectively attenuate signals carried on the electronically tunable transmission line to which they are connected according to a selected attenuation setting of a plurality of selectable attenuation settings provided by one or more attenuation control signals and thereby provide a selected attenuation to the signal pair that corresponds to the selected polarization. A corresponding method is also disclosed herein.
FILED	Wednesday, November 22, 2017
APPL NO	15/820480
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/127 (20130101) H01P 1/184 (20130101) H01P 1/227 (20130101) Antennas, i.e Radio Aerials H01Q 3/36 (20130101) H01Q 15/24 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 11/20 (20130101) H03H 11/245 (20130101) Original (OR) Class
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10680617 — Direct current powered clockless superconducting logic family using dynamic internal state

US 10680617	Rylov
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Sergey Rylov (White Plains, New York)
ABSTRACT	Techniques regarding a DSFQ logic family are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a dynamic single flux quantum logic circuit that has a self-resetting internal state and can be powered by direct current. Further, the self-resetting internal state can be characterized by two time constants.
FILED	Tuesday, October 30, 2018
APPL NO	16/174982
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Electric Digital Data Processing G06F 1/10 (20130101) Pulse Technique H03K 3/38 (20130101) H03K 19/1952 (20130101) Original (OR) Class
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10680676 — Underwater signal conversion

US 10680676	Govoni et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Mark Govoni (Abingdon, Maryland); John Suarez (Brooklyn, New York)
ABSTRACT	Various embodiments associated with signal conversion while underwater are described. A source can transmit an alternating current signal with a relatively high frequency over a relatively long distance. The alternating current signal with the relatively high frequency can be converted to an alternating current signal with a relatively low frequency. An example of this conversion can be done by converting the alternating current signal with the relatively high frequency into a direct current signal. The direct current signal can then be converted into the alternating current signal with the relatively low frequency. The alternating current signal with the relatively low frequency can be transmitted from a transmission coil to a pick-up coil. After reception by the pick-up coil the alternating current signal with the relatively low frequency can be processed, such as processed to determine a direction of the source of the alternating current signal with the relatively high frequency.
FILED	Wednesday, October 11, 2017
APPL NO	15/729830
ART UNIT	2867 — Printing/Measuring and Testing
CURRENT CPC	Transmission H04B 5/0031 (20130101) Original (OR) Class
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10680712 — Network of extremely high burst rate optical downlinks

US 10680712	Boroson et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Don M. Boroson (Needham, Massachusetts); Bryan Shawn Robinson (Arlington, Massachusetts); Bryan M. Reid (Chelmsford, Massachusetts)
ABSTRACT	Traditional satellite-to-earth data transmission systems are constrained by inefficient relay schemes and/or short-duration data transfers at low data rates. Communication systems described herein achieve extremely high burst rate (e.g., 10 Gbps or greater) direct-to-Earth (DTE) data transmission over a free-space optical link between a spacecraft and a remote terminal, which may be a ground terminal or another space terminal. The optical link is established, for example, when the remote terminal is at an elevation of 20° with respect to a horizon of the remote terminal. In some embodiments, a data transmission burst contains at least 1 Terabyte of information and has a duration of 6 minutes or less. The communication system can include forward error correction by detecting a degradation of a received free-space optical signal and re-transmitting at least a portion of the free-space optical signal.
FILED	Wednesday, December 19, 2018
APPL NO	16/225073
ART UNIT	2636 — Optical Communications
CURRENT CPC	Transmission H04B 7/18513 (20130101) H04B 10/29 (20130101) H04B 10/40 (20130101) H04B 10/61 (20130101) H04B 10/118 (20130101) Original (OR) Class H04B 10/1121 (20130101) Multiplex Communication H04J 14/02 (20130101)
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10681475 — System and method for evaluating speech perception in complex listening environments

US 10681475	Brungart et al.
FUNDED BY	Department of Defense (DOD) Defense Medical Research and Development Program (DMRDP) Department of the Army (DOA)
APPLICANT(S)	The Unites States of America Represented by the Secretary of Defense (Silver Spring, Maryland); The United States of America as Represented by the Secretary of the Army (Silver Spring, Maryland)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Defense (Bethesda, Maryland)
INVENTOR(S)	Douglas S. Brungart (Rockville, Maryland); Benjamin M Sheffield (San Luis Obispo, California)
ABSTRACT	The present application describes a plurality of test simulation environment mimic complex listening environment of everyday life, comprising a speech component, and a noise component. The application also describes an auditory testing system and method for evaluating a listener's speech perception and method to test hearing prosthesis or hearing protection device's effect on a person's speech perception in a complex listening environment.
FILED	Tuesday, February 19, 2019
APPL NO	16/279675
ART UNIT	2654 — Audio Signals
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/12 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 21/0208 (20130101) G10L 25/48 (20130101) G10L 2021/02082 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 3/04 (20130101) H04R 25/30 (20130101) Original (OR) Class H04R 2225/31 (20130101) Stereophonic Systems H04S 7/303 (20130101) H04S 2420/01 (20130101)
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Department of Energy (DOE)

10674973 — Radiation therapy system and methods of use thereof

US 10674973	Chu et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	RUSH UNIVERSITY MEDICAL CENTER (Chicago, Illinois); UCHICAGO ARGONNE, LLC, OPERATOR OF ARGONNE NATIONAL LABORATORY (Chicago, Illinois)
ASSIGNEE(S)	Rush University Medical Center (Chicago, Illinois); UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	James Chu (Oak Brook, Illinois); William F. Sensakovic (Orlando, Florida); Damian Bernard (Naperville, Illinois); Gage Redler (Chicago, Illinois); Steve Wang (Chicago, Illinois)
ABSTRACT	One aspect of the invention provides a system for radiation treatment of a tumor allowing for imaging of the tumor and a surrounding region during radiation therapy and to methods of using such a system. In one embodiment, the system includes a number of radiation detectors positioned in an array to detect radiation scattered from the tumor and the surrounding region. A 3-dimensional image of the tumor is reconstructed from the 2-dimensional scattered radiation projections.
FILED	Thursday, April 21, 2016
APPL NO	15/568103
ART UNIT	2884 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/06 (20130101) A61B 6/483 (20130101) A61B 6/583 (20130101) A61B 6/4266 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1049 (20130101) A61N 2005/1054 (20130101)
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10675364 — Rhodol fluorophores for near-infrared imaging

US 10675364	Hettie et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California); THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California); THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri)
INVENTOR(S)	Kenneth Hettie (Stanford, California); Jessica Klockow (Stanford, California); Timothy Glass (Columbia, Missouri); Frederick T. Chin (Standford, California)
ABSTRACT	The present disclosure encompasses embodiments of a novel near-infrared-emitting molecular fluorophore and probes incorporating said fluorophore advantageous for in vitro and in vivo research studies. The fluorophore is robust, photostable, and possesses functionalities for easy bioorthogonal conjugation (e.g., click chemistry, hydrazone formation, Diels Alder, Staudinger ligation, etc.). It is biocompatible and emits at 711 nm in aqueous conditions. These fluorophores may be used to fluorescently tag biological molecules or structures of interest, or used as optical reporters (i.e., activatable molecular probes, fluorescent dyes) for specific biomarkers/analytes as they can be switched from “off” to “on.” This fluorophore is useful for cellular assays and preclinical small animal imaging as the near-infrared emission is highly penetrating, and the photophysical properties are outstanding. As such, the properties of this class of fluorophores could easily be translated for use in clinical applications.
FILED	Thursday, June 23, 2016
APPL NO	15/738327
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0043 (20130101) Original (OR) Class A61K 49/0058 (20130101) Heterocyclic Compounds C07D 491/052 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 2458/00 (20130101)
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10675819 — Magnetic field alignment of emulsions to produce porous articles

US 10675819	Li et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Northeastern University (Boston, Massachusetts)
INVENTOR(S)	Linsen Li (Malden, Massachusetts); Jonathan Samuel Sander (Zurich, Switzerland); Yet-Ming Chiang (Weston, Massachusetts); Randall Morgan Erb (Newton, Massachusetts)
ABSTRACT	The use of magnetic fields in the production of porous articles is generally described. Certain embodiments are related to methods of producing porous articles in which magnetic fields are applied to an emulsion to align emulsion droplets. In some embodiments, after the emulsion droplets have been aligned, the emulsion droplets and/or the medium surrounding the emulsion droplets can be removed to leave behind a porous article. According to certain embodiments, polyvinyl alcohol can be used, for example, to stabilize the emulsion droplets and/or bind together components of the porous article. In some embodiments, water-soluble liquid alcohol can be used, for example, to stabilize the suspension of electronically conductive material within a phase of the emulsion.
FILED	Friday, December 23, 2016
APPL NO	15/390295
ART UNIT	1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/32 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 67/202 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2029/04 (20130101) B29K 2105/0064 (20130101) B29K 2995/0005 (20130101) B29K 2995/0008 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/3468 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/447 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/04 (20130101) H01M 4/131 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/587 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 4/1391 (20130101) H01M 2004/021 (20130101)
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10676088 — Powertrain control system and method of operating the same

US 10676088	Hu et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
ASSIGNEE(S)	GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
INVENTOR(S)	Yiran Hu (Shelby Township, Michigan); Junfeng Zhao (Shelby Township, Michigan); Steven E. Muldoon (Pontiac, Michigan); Chen-Fang Chang (Pontiac, Michigan)
ABSTRACT	A system and method are provided for operating a powertrain control system. The method includes receiving data measured from a plurality of sensors, the measured data relating to distance dependent speed values, and receiving information from one or more vehicle modules, the vehicle module information relating to distance independent speed values. The method further includes building a speed trajectory profile for a horizon window that includes a plurality of speed change regions represented by at least some distance dependent speed values or at least some distance independent speed values, and creating a synthesized speed profile for the horizon window by processing the speed trajectory profile. The synthesized speed profile optimizes efficiency of the powertrain control system at each of the plurality of speed change regions.
FILED	Friday, June 08, 2018
APPL NO	16/003223
ART UNIT	3667 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/143 (20130101) Original (OR) Class B60W 2554/801 (20200201) B60W 2554/804 (20200201)
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10676467 — Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof

US 10676467	Tu et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Zhude Tu (Frontenac, Missouri); Adam Rosenberg (Nashville, Missouri); Hui Liu (Creve Coeur, Missouri); Junbin Han (Shanghai, China PRC)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Zhude Tu (Frontenac, Missouri); Adam Rosenberg (Nashville, Missouri); Hui Liu (Creve Coeur, Missouri); Junbin Han (Shanghai, China PRC)
ABSTRACT	Among the various aspects of the present disclosure is the provision of a compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof. Provided are imaging agents for imaging S1P1 and S1P1 associated diseases, disorders, and conditions. Also provided are therapeutic compositions and methods for the treatment of S1P1 associated diseases, disorders, and conditions.
FILED	Monday, July 02, 2018
APPL NO	16/025324
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) C07B 2200/05 (20130101) Heterocyclic Compounds C07D 271/06 (20130101) C07D 413/04 (20130101) Original (OR) Class C07D 413/10 (20130101) C07D 413/12 (20130101)
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10676586 — Nanocomposite additives based on graphene sheets and silica nanofibers

US 10676586	Polyzos et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-Battelle LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Georgios Polyzos (Knoxville, Tennessee); Jaswinder K. Sharma (Oak Ridge, Tennessee); Ivan V. Vlassiouk (Oak Ridge, Tennessee); Daniel A. Schaffer (Knoxville, Tennessee); Panagiotis G. Datskos (Knoxville, Tennessee); Timothy J. LaClair (Oak Ridge, Tennessee); Jaehyeung Park (Busan, South Korea)
ABSTRACT	A method for producing a composite polymeric article, an additive for a polymeric article, and a composite polymeric article are provided. The method generally includes providing a plurality of graphene nanoplatelets, providing a plurality of silica nanofibers, providing a polymeric material, and distributing the plurality of silica nanofibers and the plurality of graphene nanoplatelets within the polymeric material to achieve a composite article. The additive for a polymeric article includes a plurality of graphene nanoplatelets and a plurality of silica nanofibers. The composite polymeric article includes a plurality of graphene nanoplatelets, a plurality of silica nanofibers, and a polymeric matrix. The plurality of graphene nanoplatelets and the plurality of silica nanofibers are distributed within the polymeric matrix. The silica nanofibers have a mean cross sectional diameter of not more than 100 nm.
FILED	Wednesday, June 06, 2018
APPL NO	16/000975
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) C08K 3/042 (20170501) Original (OR) Class C08K 3/042 (20170501) C08K 7/10 (20130101) C08K 9/06 (20130101) C08K 9/06 (20130101) C08K 2201/003 (20130101) C08K 2201/006 (20130101) Compositions of Macromolecular Compounds C08L 9/06 (20130101) C08L 9/06 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/08 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/06 (20130101)
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10676629 — Methods for preparation of concentrated graphene ink compositions and related composite materials

US 10676629	Hersam et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Mark C. Hersam (Wilmette, Illinois); Yu Teng Liang (Chicago, Illinois); Ethan B. Secor (Evanston, Illinois); Pradyumna L. Prabhumirashi (Chicago, Illinois); Kanan P. Puntambekar (Chicago, Illinois); Michael L. Geier (Chicago, Illinois)
ABSTRACT	A rapid, scalable methodology for graphene dispersion and concentration with a polymer-organic solvent medium, as can be utilized without centrifugation, to enhance graphene concentration.
FILED	Monday, December 04, 2017
APPL NO	15/830508
ART UNIT	1764 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/14 (20130101) C09D 11/38 (20130101) Original (OR) Class C09D 11/52 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/24 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/31721 (20150401) Y10T 428/31786 (20150401)
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10676975 — Door assembly with collapsible carrier

US 10676975	Fortin et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Magna Closures Inc. (Newmarket, Canada)
ASSIGNEE(S)	MAGNA CLOSURES INC. (New Market, Ontario, Canada)
INVENTOR(S)	Raymond Edward Fortin (Newmarket, Canada); Eric V. Kalliomaki (Uxbridge, Canada); Amandeep Kalra (Markham, Canada)
ABSTRACT	A door assembly for a motor vehicle comprised of an outer door panel and an inner door panel interconnected to define a door panel structure having an internal door cavity. A collapsible carrier module is configured to be oriented in a collapsed arrangement to facilitate installation into the door cavity through an opening in the inner door panel. The collapsible carrier module can be moved from its collapsed arrangement into an expanded arrangement upon installation within the door cavity to facilitate subsequent mounting to the door panel structure. The collapsible carrier module includes a two-piece carrier plate formed to integrally include a pair of laterally-spaced glass run channels and a pair of laterally-spaced slider rails.
FILED	Wednesday, April 26, 2017
APPL NO	15/497437
ART UNIT	3634 — Static Structures, Supports and Furniture
CURRENT CPC	Windows, Windscreens, Non-fixed Roofs, Doors, or Similar Devices for Vehicles; Removable External Protective Coverings Specially Adapted for Vehicles B60J 1/17 (20130101) B60J 5/0416 (20130101) B60J 5/0429 (20130101) B60J 5/0431 (20130101) B60J 5/0433 (20130101) B60J 5/0448 (20130101) Hinges or Suspension Devices for Doors, Windows or Wings E05D 15/165 (20130101) Original (OR) Class Indexing Scheme Relating to Hinges or Other Suspension Devices for Doors, Windows or Wings and Devices for Moving Wings into Open or Closed Position, Checks for Wings and Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing E05Y 2900/531 (20130101)
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10677046 — Leakage detection using smart field technology

US 10677046	Mohaghegh et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	West Virginia University (Morgantown, West Virginia)
ASSIGNEE(S)	West Virginia University (Morgantown, West Virginia)
INVENTOR(S)	Shahab D. Mohaghegh (Morgantown, West Virginia); Seyed Alireza Haghighat (State College, Pennsylvania)
ABSTRACT	Various examples are provided for gas leakage detection from geologic storage sites. In one example, a system for detection of gas leakage from a geologic storage site includes permanent down-hole gauges (PDGs) disposed at different depths within a well and an evaluation system that can determine a three-dimensional (3D) location of the gas leakage from the geologic storage site and a leakage indicator. The 3D location and leakage indicator can be determined using pressure data provided by the PDGs. The geologic storage site can store, e.g., CO₂, natural gas or other type of gas. In another example, a method for detecting gas leakage from a geologic storage site includes receiving pressure data provided by PDGs disposed within one or more wells associated with the geologic storage site, determining key performance indicators using the pressure data and determining a 3D location and a leakage indicator using the key performance indicators.
FILED	Tuesday, April 05, 2016
APPL NO	15/091176
ART UNIT	2894 — Semiconductors/Memory
CURRENT CPC	Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 41/0064 (20130101) E21B 47/10 (20130101) Original (OR) Class Capture, Storage, Sequestration or Disposal of Greenhouse Gases [GHG] Y02C 10/14 (20130101)
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10677458 — Combustor assembly for low-emissions and alternate liquid fuels

US 10677458	Agrawal
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama)
ASSIGNEE(S)	The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama)
INVENTOR(S)	Ajay K. Agrawal (Tuscaloosa, Alabama)
ABSTRACT	Implementations of a combustor assembly yield low emissions, require low power, are suitable for alternate liquid fuels, including highly viscous fuels, and are scalable for various heat release rates. The combustor assembly includes a fuel injector and a swirler. The fuel injector may include a choke portion and a spacer. The choke portion is disposed just upstream of an outlet of a liquid fuel conduit and prevents atomizing gas from interrupting continuous flow of the liquid fuel through the liquid fuel conduit. The spacer is disposed downstream of the outlet to precisely control the gap and thus, bifurcation of atomizing gas flow, between the outlet of liquid fuel conduit and an inlet of an orifice plate. The swirler is disposed radially outwardly and adjacent the fuel injector and includes a plurality of angled vanes.
FILED	Tuesday, April 11, 2017
APPL NO	15/484197
ART UNIT	3762 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Methods or apparatus for combustion using fluid fuel or Solid Fuel Suspended In Air F23C 7/004 (20130101) Burners F23D 11/14 (20130101) F23D 11/38 (20130101) F23D 11/101 (20130101) F23D 11/107 (20130101) Original (OR) Class F23D 11/383 (20130101) F23D 17/002 (20130101)
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10677466 — Combustor inlet flow conditioner

US 10677466	Berry et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Jonathan Dwight Berry (Simpsonville, South Carolina); Brandon Lamar Bush (Simpsonville, South Carolina); Timothy James Purcell (Greenville, South Carolina); Lucas John Stoia (Taylors, South Carolina)
ABSTRACT	A combustor includes an inlet flow conditioner. The inlet flow conditioner includes a sleeve that circumferentially surrounds a portion of a fuel nozzle assembly and that extends from a forward end of a combustion liner to an inner surface of an end cover. The sleeve defines a plurality of apertures circumferentially spaced about the sleeve. A portion of the inner surface of the end cover and the sleeve define a head end volume of the combustor. An inlet to a premix passage of at least one fuel nozzle of the fuel nozzle assembly is disposed within and is in fluid communication with the head end volume.
FILED	Thursday, October 13, 2016
APPL NO	15/292485
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/04 (20130101) F23R 3/286 (20130101) Original (OR) Class F23R 2900/00012 (20130101)
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10677501 — Component and efficient plate and frame absorber

US 10677501	Moghaddam et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Saeed Moghaddam (Gainesville, Florida); Mehdi Mortazavi (Gainesville, Florida); Sajjad Bigham (Gainesville, Florida)
ABSTRACT	An absorber for an absorption refrigeration system for a vertically mounted plate absorber has fins positioned over the plate to promote distribution of a fluid under flow as a nearly continuous thin film. The absorber has rows of fins that are evenly spaced with the fins occupying a portion of the active width of the plate with adjacent rows offset by the width of the plate. A combined evaporator-absorber module is constructed with the absorbing face of the absorber parallel with an evaporating surface of an evaporator where absorber solution and refrigerant fall as parallel falling sheets of liquid. The absorber is covered with a porous hydrophobic membrane to isolate the falling absorber solution from the falling liquid refrigerant.
FILED	Monday, September 26, 2016
APPL NO	15/762333
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 15/06 (20130101) F25B 37/00 (20130101) Original (OR) Class Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 2021/0064 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 3/027 (20130101) F28F 13/182 (20130101) F28F 2245/02 (20130101) Technologies for Adaptation to Climate Change Y02A 30/277 (20180101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 30/62 (20130101)
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10677726 — Tunable diode laser absorption spectroscopy with corrected laser ramping nonlinearities

US 10677726	Green et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	William Green (Yorktown Heights, New York); Chu Cheyenne Teng (Yorktown Heights, New York); Gerard Wysocki (Yorktown Heights, New York); Chi Xiong (Yorktown Heights, New York); Eric Zhang (Yorktown Heights, New York)
ABSTRACT	A tunable diode laser absorption spectroscopy device includes a tunable diode laser. A laser driver is configured to drive the diode laser and ramp it within a particular frequency range. An analyte gas container, a reference gas container, and a fringe generating device are configured to receive the laser therethrough. An optical detector is configured to detect the laser after it has passed through the analyte gas container and/or the reference gas container, and the in-line fringe generating device. An acquisition card is configured to sample an output of the optical detector. A spectral analyzer is configured to receive output data from the acquisition card, determine a spectrum of the output data, decouple the fringe spectrum from the measured spectrum, calibrate the spectrum based on an expected ideal spectrum of both the fringe and reference gas, and determine a composition of the analyte based on the calibrated spectrum.
FILED	Tuesday, December 19, 2017
APPL NO	15/846912
ART UNIT	2886 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/39 (20130101) G01N 21/45 (20130101) Original (OR) Class G01N 21/274 (20130101) G01N 2021/399 (20130101)
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10677744 — Multi-cone x-ray imaging Bragg crystal spectrometer

US 10677744	Bitter et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Princeton Plasma Physics Laboratory (PPPL) Federally Funded Research and Development Center (FFRDC) Operated by Princeton University (PRINCETON) at Princeton, NJ
APPLICANT(S)	Energy, United States Department of (Washington, District of Columbia)
ASSIGNEE(S)	U.S. Department of Energy (Washington, District of Columbia)
INVENTOR(S)	Manfred Bitter (Princeton, New Jersey); Kenneth W. Hill (Plainsboro, New Jersey); Philip Efthimion (Bedminster, New Jersey); Luis Delgado-Apariccio (Princeton, New Jersey); Novimir Pablant (Princeton, New Jersey); Lan Gao (Princeton, New Jersey); Brian Kraus (Princeton, New Jersey)
ABSTRACT	Embodiments provide a multi-cone X-ray imaging Bragg crystal spectrometer for spectroscopy of small x-ray sources with a well-defined spectral resolution. The spectrometer includes a glass substrate machined to a multi-cone form; and a thin crystal slab attached to the glass substrate, whereby the multi-cone X-ray imaging Bragg crystal spectrometer provides rotational symmetry of a ray pattern, providing for accurate imaging, for each wavelength in the spectral range of interest. One or more embodiments include a streak camera and/or a gated strip detector.
FILED	Monday, June 05, 2017
APPL NO	15/614545
ART UNIT	2884 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/20 (20130101) G01N 23/207 (20130101) G01N 23/20008 (20130101) Original (OR) Class G01N 23/20091 (20130101) G01N 2223/05 (20130101) G01N 2223/056 (20130101) G01N 2223/0568 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/06 (20130101) G21K 1/062 (20130101)
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10677771 — Detecting gas leaks using unmanned aerial vehicles

US 10677771	Dittberner et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Matthias Dittberner (Neustrelitz, Germany); Levente Klein (Tuckahoe, New York); Jason D. Renwick (Santa Cruz, Trinidad/Tobago)
ABSTRACT	Methods, systems and computer program products for detecting gas leaks using a drone are provided. Aspects include capturing a first set of data regarding a presence of a gas in the geographic area while flying along the initial flight path. Aspects also include creating secondary flight paths through regions in the geographic area in which the presence of the gas exceeds a threshold amount and capturing a second set of data regarding a concentration of the gas in the one or more regions while flying along the secondary flight paths. Aspects further include capturing wind data while flying along the initial and second flight paths and creating a three-dimensional gas plume model for gas leaks identified in the geographic area based on the first set of data, the second set of data and the wind data, wherein the three-dimensional gas plume model identifies a source of the gas leaks.
FILED	Wednesday, November 01, 2017
APPL NO	15/800116
ART UNIT	3669 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/024 (20130101) B64C 2201/123 (20130101) B64C 2201/127 (20130101) B64C 2201/141 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/00 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3504 (20130101) G01N 33/0047 (20130101) Original (OR) Class G01N 2021/0143 (20130101) G01N 2021/1795 (20130101) G01N 2201/0214 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) G05D 1/0094 (20130101) G05D 1/101 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0063 (20130101) G06K 9/00201 (20130101) G06K 9/2018 (20130101) Image Data Processing or Generation, in General G06T 7/73 (20170101) G06T 17/05 (20130101) G06T 2207/10032 (20130101) G06T 2207/10048 (20130101) G06T 2207/30181 (20130101) Traffic Control Systems G08G 5/0013 (20130101) G08G 5/0021 (20130101) G08G 5/0034 (20130101) G08G 5/0039 (20130101) G08G 5/0069 (20130101) G08G 5/0086 (20130101)
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10678293 — Systems for mechanical logic based on additively manufacturable micro-mechanical logic gates

US 10678293	Pascall et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Andrew Pascall (Livermore, California); Julie Mancini (Livermore, California); Robert Matthew Panas (Dublin, California); Yuanping Song (Los Angeles, California); Jonathan Hopkins (Los Angeles, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California); The Regents of the University of California (Oakland, California)
INVENTOR(S)	Andrew Pascall (Livermore, California); Julie Mancini (Livermore, California); Robert Matthew Panas (Dublin, California); Yuanping Song (Los Angeles, California); Jonathan Hopkins (Los Angeles, California)
ABSTRACT	The present disclosure is directed to various mechanical logic gates. In one example a mechanical logic NOT gate system is formed which has a first pair of bi-stable buckling structures each being operatively connected at a first connection point thereof to one another, and also to a first rigid structure at second connection points, the first rigid structure being held stationary. A second pair of bi-stable buckling flexures is each operatively connected at first connection points thereof to each other and at second connection points thereof to a second rigid structure being held stationary. An output element is coupled a first one of each of the first and second pairs of bi-stable buckling structures. An input element is coupled to a second one of each of the first and second pairs of bi-stable buckling structures. The output element moves from a logic 1 position to a logic 0 position in response to movement of the input element from a logic 0 position to a logic 1 positions, respectively.
FILED	Friday, November 02, 2018
APPL NO	16/178690
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Digital Computers in Which All the Computation Is Effected Mechanically G06C 21/04 (20130101) Original (OR) Class Pulse Technique H03K 19/02 (20130101) H03K 19/20 (20130101)
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10678937 — Resolution system that provides access to remote data locally

US 10678937	Smith et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Jeff W. Smith (Oak Ridge, Tennessee); Shaun S. Gleason (Oak Ridge, Tennessee); Michael L. Baker (Oak Ridge, Tennessee); David L. Bond (Oak Ridge, Tennessee); Gregory L. Capps (Oak Ridge, Tennessee); Robert A. Franklin (Oak Ridge, Tennessee); Kimberly B. Jeskie (Oak Ridge, Tennessee)
ABSTRACT	A system and method that provides access to remote data locally by identifying and downloading linked content from a plurality of remote sources through a communication network; decomposing the downloaded content into local content elements by intercepting links between the content elements and mapping the intercepted links to redirected links that locate the same download content in a local cache or a local server proxy; identifying remote devices requesting access to the local cache or the local server proxy and the device's functionality through a tracking code stored on the remote devices and a probabilistic tracking; and providing access to the local cache or the local server proxy in response to authorizations associated with the identified devices and a user.
FILED	Thursday, December 14, 2017
APPL NO	15/842507
ART UNIT	2495 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 3/067 (20130101) G06F 3/0623 (20130101) G06F 3/0637 (20130101) G06F 3/0659 (20130101) G06F 12/0875 (20130101) G06F 21/44 (20130101) G06F 21/6218 (20130101) Original (OR) Class G06F 2212/60 (20130101) G06F 2212/154 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/06 (20130101) H04L 67/2814 (20130101) H04L 67/2823 (20130101) H04L 67/2842 (20130101)
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10679523 — Tamper indicating seal

US 10679523	Weeks et al.
FUNDED BY	Department of Energy (DOE) Office of Environmental Management (DOE-EM) Savannah River National Laboratory (SRNL) Federally Funded Research and Development Center (FFRDC) Operated by Savannah River Nuclear Solutions, LLC (SRNS) at Aiken, SC
APPLICANT(S)	Savannah River Nuclear Solutions, LLC (Aiken, South Carolina)
ASSIGNEE(S)	Savannah River Nuclear Solutions, LLC (Aiken, South Carolina)
INVENTOR(S)	George E. Weeks (Aiken, South Carolina); Keith Tolk (Aiken, South Carolina); Jennifer E. Tanner (Aiken, South Carolina); Jacob Benz (Aiken, South Carolina); Keir C. Allen (Aiken, South Carolina); Helen M. White (Aiken, South Carolina); Daniel Krementz (Aiken, South Carolina); Lawrence J. Harpring (Aiken, South Carolina); Raymond R. Lawson (Aiken, South Carolina)
ABSTRACT	A system and method for detecting tampering with a seal is provided. A loop seal tamper indicating device includes a seal wire that may be passed through a secured item or container to form a loop with the free ends of the seal wire passing through a seal housing. A plunger body including an adhesive-filled cavity is inserted into the seal housing, such that a piston expresses the adhesive into the space between the seal housing and the plunger body. The adhesive may contain reflective particles and is cured to fix the particles and the adhesive in place. A reference image may be taken to record the unique identifier and reflective signature of the adhesive. Future validation images may be compared to the reference image to determine whether the reflective signature has changed, thus indicating that the seal has been tampered with.
FILED	Tuesday, July 26, 2016
APPL NO	15/219388
ART UNIT	3675 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1447 (20130101) Displaying; Advertising; Signs; Labels or Name-plates; Seals G09F 3/0317 (20130101) G09F 3/0352 (20130101) Original (OR) Class G09F 3/0376 (20130101) G09F 3/0382 (20130101) G09F 2003/0239 (20130101)
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10679761 — Containers and refractory metal coating therefore for containing radioactive materials

US 10679761	Farmer et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawerence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Joseph C. Farmer (Tracy, California); Jor-Shan Choi (El Cerrito, California); Alexander M. Rubenchik (Livermore, California)
ABSTRACT	Fabricating structural components for a spent nuclear fuel container using the steps of forming cylindrical or rectangular channels to produce a structural component for a spent nuclear fuel container and applying a coating that includes tantalum-based material to the cylindrical or rectangular channels.
FILED	Friday, March 14, 2014
APPL NO	14/213120
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Apparatus for Applying Fluent Materials to Surfaces, in General B05C 9/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/00 (20130101) C23C 24/00 (20130101) Nuclear Reactors G21C 3/00 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 1/00 (20130101) Original (OR) Class G21F 5/00 (20130101)
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10679816 — Thermionic cathode with a graphene sealing layer and method of making the same

US 10679816	Moody et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Nathan Moody (Los Alamos, New Mexico); Gautam Gupta (Los Alamos, New Mexico); Aditya Mohite (Los Alamos, New Mexico)
ABSTRACT	According to an embodiment of the present disclosure, a thermionic cathode includes: a cathode body having an outer surface, and a sealing layer including one or more graphene sheets on the outer surface of the cathode body. According to another embodiment of the present disclosure, a method for manufacturing a thermionic cathode includes: depositing a sealing layer including one or more graphene sheets on an outer surface of a cathode body.
FILED	Friday, July 07, 2017
APPL NO	15/644704
ART UNIT	2879 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 1/142 (20130101) Original (OR) Class H01J 9/042 (20130101) H01J 2201/02 (20130101)
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10680123 — Article with transparent conductive oxide coating

US 10680123	McCamy et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Vitro Flat Glass LLC (Cheswick, Pennsylvania)
ASSIGNEE(S)	Vitro Flat Glass LLC (Cheswick, Pennsylvania)
INVENTOR(S)	James W. McCamy (Export, Pennsylvania); Zhixun Ma (Cheswick, Pennsylvania); Benjamin Kabagambe (Pittsburgh, Pennsylvania); Kwaku K. Koram (Wexford, Pennsylvania); Cheng-Hung Hung (Wexford, Pennsylvania); Gary J. Nelis (Pittsburgh, Pennsylvania)
ABSTRACT	A solar cell includes a first substrate having a first surface and a second surface. An underlayer is located over the second surface. A first conductive layer is located over the underlayer. An overlayer is located over the first conductive layer. A semiconductor layer is located over the conductive oxide layer. A second conductive layer is located over the semiconductor layer. The first conductive layer includes a conductive oxide and at least one dopant selected from the group consisting of tungsten, molybdenum, niobium, and/or fluorine.
FILED	Wednesday, December 09, 2015
APPL NO	14/963778
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Manufacture, Shaping, or Supplementary Processes C03B 17/06 (20130101) C03B 18/14 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/36 (20130101) C03C 17/3411 (20130101) C03C 17/3417 (20130101) C03C 17/3631 (20130101) C03C 17/3668 (20130101) C03C 17/3678 (20130101) C03C 2217/94 (20130101) C03C 2217/948 (20130101) C03C 2218/1525 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/40 (20130101) C23C 16/54 (20130101) C23C 16/407 (20130101) C23C 16/4412 (20130101) C23C 16/45561 (20130101) C23C 16/45595 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/0749 (20130101) H01L 31/02167 (20130101) H01L 31/02168 (20130101) Original (OR) Class H01L 31/02327 (20130101) H01L 31/03923 (20130101) H01L 31/022425 (20130101) H01L 31/022466 (20130101) H01L 51/0096 (20130101) H01L 51/442 (20130101) H01L 51/5215 (20130101) H01L 51/5268 (20130101) H01L 51/5281 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/541 (20130101) Y02E 10/549 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/521 (20151101)
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10680231 — Mesoporous nickel-iron-manganese-alloy based metal/metal oxide composite thick film catalysts

US 10680231	Tolbert et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Sarah Tolbert (Los Angeles, California); Eric Detsi (Philadelphia, Pennsylvania); Benjamin Lesel (Los Angeles, California)
ABSTRACT	Selective alloy corrosion is used to synthesize a robust and ultrafine mesoporous NiFeMn-based metal/metal oxide oxygen evolving catalyst with ligament and pore sizes in the range of 10 nm and a BET surface area of 43 m²/g. As an oxygen evolving catalyst, the mesoporous catalyst exhibits high stability (>264 hours) at a high current density (500 mA/cm²) with a low overpotential (360 mV) using a moderate electrolyte concentration (1 M KOH). The catalyst is made from non-precious metals and its fabrication is straight forward and directly applicable to large-scale synthesis.
FILED	Sunday, May 27, 2018
APPL NO	15/990650
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/78 (20130101) B01J 23/80 (20130101) B01J 23/8476 (20130101) B01J 23/8892 (20130101) B01J 35/0033 (20130101) B01J 35/1014 (20130101) B01J 35/1061 (20130101) B01J 37/06 (20130101) B01J 2523/00 (20130101) B01J 2523/00 (20130101) B01J 2523/72 (20130101) B01J 2523/842 (20130101) B01J 2523/847 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Alloys C22C 38/04 (20130101) C22C 38/08 (20130101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/00 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/10 (20130101) C25B 9/08 (20130101) C25B 11/035 (20130101) C25B 11/0447 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/02 (20130101) Original (OR) Class H01M 8/0232 (20130101) H01M 2004/021 (20130101) H01M 2004/027 (20130101) H01M 2004/028 (20130101) H01M 2300/0005 (20130101) H01M 2300/0014 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/366 (20130101)
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10680234 — Lithium-sulfur battery with polyanthraquinone binder

US 10680234	Liao et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S)	Chen Liao (Westmont, Illinois); Ka-Cheong Lau (Chicago, Illinois)
ABSTRACT	A cathode for a lithium-sulfur (Li—S) battery is described herein, which comprises elemental sulfur (e.g., S₈) and an electroactive polyanthraquinone-containing binder. In some embodiments, the cathode also includes a conductive carbon material in addition to the sulfur and binder. Also described herein is a Li—S battery comprising the cathode, in combination with a metallic lithium-containing anode, a lithium conductive separator membrane between the anode and the cathode, and a liquid electrolyte comprising a lithium salt dissolved in a non-aqueous organic solvent.
FILED	Wednesday, March 28, 2018
APPL NO	15/938026
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/136 (20130101) Original (OR) Class H01M 4/583 (20130101) H01M 4/623 (20130101) H01M 4/661 (20130101)
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10680236 — High capacity monolithic composite Si/carbon fiber electrode architectures synthesized from low cost materials and process technologies

US 10680236	Rios et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Orlando Rios (Knoxville, Tennessee); Claus Daniel (Knoxville, Tennessee); Wyatt Evan Tenhaeff (Rochester, New York); Surendra K. Martha (Knoxville, Tennessee)
ABSTRACT	A composite Si-carbon fiber comprising a carbon matrix material with 1-90 wt % silicon embedded therein. The composite carbon fibers are incorporated into electrodes for batteries. The battery can be a lithium ion battery. A method of making an electrode incorporating composite Si-carbon fibers is also disclosed.
FILED	Thursday, February 08, 2018
APPL NO	15/892086
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/362 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/587 (20130101) H01M 4/1393 (20130101) H01M 4/1395 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2918 (20150115)
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10680249 — Nitride stabilized core/shell nanoparticles

US 10680249	Kuttiyiel et al.
FUNDED BY	Department of Energy (DOE) Brookhaven Science Associates, LLC (BSA) Office of Science (DOE-SC) Brookhaven National Laboratory (BNL) Federally Funded Research and Development Center (FFRDC) Operated by Brookhaven Science Associates, LLC (BSA) at Upton, NY
APPLICANT(S)	Brookhaven Science Associates, LLC (Upton, New York)
ASSIGNEE(S)	Brookhaven Science Associates, LLC (Upton, New York)
INVENTOR(S)	Kurian Abraham Kuttiyiel (New Hyde Park, New York); Kotaro Sasaki (Hauppauge, New York); Radoslav R. Adzic (East Setauket, New York)
ABSTRACT	Nitride stabilized metal (M or Pt(M)) nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling. Introduction of nitrogen into the core by annealing produces metal nitride(s) that are less susceptible to dissolution during potential cycling under high oxidizing conditions.
FILED	Friday, February 08, 2019
APPL NO	16/271496
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/925 (20130101) H01M 4/8657 (20130101) Original (OR) Class H01M 2008/1095 (20130101)
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10680263 — Methods and systems for operating a redox flow battery system

US 10680263	Song et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	ESS TECH, INC. (Wilsonville, Oregon)
ASSIGNEE(S)	ESS TECH, INC. (Wilsonville, Oregon)
INVENTOR(S)	Yang Song (West Linn, Oregon); Evan Doremus (Portland, Oregon); Thiago Groberg (Tigard, Oregon)
ABSTRACT	A method of operating a redox flow battery, may include maintaining a positive electrode compartment pressure greater than a negative electrode compartment pressure, and maintaining a cross-over pressure less than a membrane break-through pressure, wherein the cross-over pressure equals the negative electrode compartment pressure subtracted from the positive electrode compartment pressure. In this way, ionic resistance across the separator can be maintained at a lower level by reducing gas bubbles trapped therein while reducing separator break-through, thereby increasing performance of the redox flow battery system.
FILED	Friday, April 27, 2018
APPL NO	15/965709
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) H01M 8/04186 (20130101) H01M 8/04201 (20130101) H01M 8/04641 (20130101) H01M 8/04753 (20130101) H01M 8/04783 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/528 (20130101)
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10680265 — Energy storage using an REP with an engine

US 10680265	Jahnke et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	FuelCell Energy, Inc. (Danbury, Connecticut)
ASSIGNEE(S)	FUELCELL ENERGY, INC. (Danbury, Connecticut)
INVENTOR(S)	Fred C. Jahnke (Rye, New York); Matthew Lambrech (Sherman, Connecticut)
ABSTRACT	An energy storage system includes a power plant configured to generate an exhaust gas comprising carbon dioxide. The energy storage system further includes a first fuel cell configured to operate in reverse as an electrolyzer. The first fuel cell is configured to receive at least a portion of the exhaust gas from the power plant. An anode is configured to receive carbon dioxide via the exhaust gas and methane from a separate feed, and the anode is configured to output a hydrogen-containing gas mixture. The energy storage system further includes a reformer configured to methanate the hydrogen-containing gas mixture to convert substantially all of the carbon monoxide in the hydrogen-containing gas mixture to methane. The energy storage system further includes a second fuel cell operating in reverse as a hydrogen pump, the second fuel cell configured to separate hydrogen from a gas mixture output by the reformer.
FILED	Tuesday, May 15, 2018
APPL NO	15/980305
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 3/38 (20130101) C01B 2203/067 (20130101) C01B 2203/0233 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/00 (20130101) C25B 1/02 (20130101) C25B 15/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/184 (20130101) H01M 8/0612 (20130101) Original (OR) Class H01M 16/003 (20130101) H01M 2250/407 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/366 (20130101) Y02E 60/528 (20130101) Y02E 60/566 (20130101)
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10680268 — Method and system to maintain electrolyte stability for all-iron redox flow batteries

US 10680268	Evans et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	ESS TECH, INC. (Wilsonville, Oregon)
ASSIGNEE(S)	ESS TECH, INC. (Wilsonville, Oregon)
INVENTOR(S)	Craig E. Evans (West Linn, Oregon); Yang Song (West Linn, Oregon)
ABSTRACT	Methods and systems are provided which maintain the positive and negative electrolyte pH and stability of a redox flow battery through the use of electrochemical rebalancing cells. The electrochemical cells may be activated by applying an electrical load to affect changes to the pH of the electrolytes. The use of the electrochemical cells improves long term performance stability redox flow batteries by decreasing and/or eliminating Fe(OH)₃precipitation formation.
FILED	Tuesday, November 20, 2018
APPL NO	16/196332
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/184 (20130101) H01M 8/188 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/528 (20130101)
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10680285 — Salts for multivalent ion batteries

US 10680285	Liao et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S)	Chen Liao (Willowbrook, Illinois); Trevor L. Dzwiniel (Carol Stream, Illinois); Baofei Pan (Woodridge, Illinois); Sang-Don Han (Woodridge, Illinois); Anthony Burrell (Naperville, Illinois)
ABSTRACT	Methods for preparing electrolyte salts for alkaline earth metal-ion batteries (e.g., calcium and magnesium ion batteries) are described. The electrolyte salts comprise alkaline earth metal (e.g., Mg or Ca) salts of 3,4-dicyano-2-trifluoromethylimidazole (TDI). The methods comprise contacting TDI with an alkaline earth metal bis(trifluoroacetate) salt in trifluoroacetic acid.
FILED	Monday, July 02, 2018
APPL NO	16/025676
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 21/084 (20130101) C01B 21/086 (20130101) Heterocyclic Compounds C07D 233/90 (20130101) C07D 233/93 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/054 (20130101) H01M 10/0563 (20130101) H01M 10/0568 (20130101) Original (OR) Class H01M 10/0569 (20130101)
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10680403 — Bulk direct gap MoS2 by plasma induced layer decoupling

US 10680403	Cronin et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF)
APPLICANT(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California); REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	University of Southern California (Los Angeles, California); The Regents of the University of California (Oakland, California)
INVENTOR(S)	Stephen B. Cronin (South Pasadena, California); Rohan Dhall (Los Angeles, California); Roger Lake (Riverside, California); Zhen Li (Los Angeles, California); Mahesh Neupane (Riverside, California); Darshana Wickramaratne (Riverside, California)
ABSTRACT	Bulk direct transition metal dichalcogenide (TMDC) may have an increased interlayer separation of at least 0.5, 1, or 3 angstroms more than its bulk value. The TMDC may be a bulk direct band gap molybdenum disulfide (MoS2) or a bulk direct band gap tungsten diselenide (WSe₂). Oxygen may be between the interlayers. A device may include the TMDC, such as an optoelectronic device, such as an LED, solid state laser, a photodetector, a solar cell, a FET, a thermoelectric generator, or a thermoelectric cooler. A method of making bulk direct transition metal dichalcogenide (TMDC) with increased interlayer separation may include exposing bulk direct TMDC to a remote (aka downstream) oxygen plasma. The plasma exposure may cause an increase in the photoluminescence efficiency of the TMDC, more charge neutral doping, or longer photo-excited carrier lifetimes, as compared to the TMDC without the plasma exposure.
FILED	Wednesday, December 16, 2015
APPL NO	15/536628
ART UNIT	1761 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 2204/28 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/06 (20130101) C01G 41/00 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/06 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/032 (20130101) H01L 33/26 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/0612 (20130101) H01S 5/02415 (20130101) Original (OR) Class H01S 5/02453 (20130101)
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10680807 — Quantum self-authenticating timing system

US 10680807	Grice
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-Battelle LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Warren P. Grice (Oak Ridge, Tennessee)
ABSTRACT	An improved method of distributing timing information is provided. The method includes transmitting encrypted timing signals from two or more beacons at different locations. The encrypted timing signals are transmitted at regular intervals and are received by a receiver. The receiver then performs a logic operation on the encrypted timing signals and validates, based on the logic operation, the authenticity of the timing signals. The logic operation also results in a decrypted message from the beacons, which can contain additional information, for example, data to be sent back to the beacons to verify receipt.
FILED	Friday, May 25, 2018
APPL NO	15/989322
ART UNIT	2437 — Cryptography and Security
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/30 (20130101) G01S 19/243 (20130101) G01S 19/256 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0838 (20130101) H04L 9/0852 (20130101) Original (OR) Class H04L 9/0858 (20130101) H04L 63/08 (20130101) H04L 63/0435 (20130101) H04L 2463/062 (20130101) Wireless Communication Networks H04W 12/001 (20190101) H04W 12/06 (20130101) H04W 12/00502 (20190101) H04W 12/04033 (20190101)
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National Science Foundation (NSF)

10675008 — Steerable biopsy needle

US 10675008	Ryu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Seok Chang Ryu (Stanford, California); Mark Cutkosky (Palo Alto, California); Richard J. Black (Menlo Park, California); Joannes Mario Costa (Rancho La Costa, California); Behzad Moslehi (Los Altos, California); Fereydoun Faridian (Atherton, California); Levy Oblea (Union City, California); Vahid Sotoudeh (Los Altos, California)
ASSIGNEE(S)	Intelligent Fiber Optic Systems, Inc. (San Jose, California)
INVENTOR(S)	Seok Chang Ryu (Stanford, California); Mark Cutkosky (Palo Alto, California); Richard J. Black (Menlo Park, California); Joannes Mario Costa (Rancho La Costa, California); Behzad Moslehi (Los Altos, California); Fereydoun Faridian (Atherton, California); Levy Oblea (Union City, California); Vahid Sotoudeh (Los Altos, California)
ABSTRACT	A biopsy needle has a cylindrical shell outer cannula and a stylet consisting of an inner stylet and outer stylet, both of which are inserted into the cylindrical cannula. The outer stylet has a series of strain relieved slits which provide bending over a deflection region in one direction, and the outer stylet is formed from a material such as a shape memory alloy (SMA) having a superelastic phase. The deflection is generated by an SMA wire spanning a deflection extent and attached to the outer stylet on either side of the deflection extent. The inner stylet, when positioned inside the outer stylet, has one or more actuation fibers which couple optical energy into the SMA wire, causing a deflection of the outer stylet over the deflection extent, with the optical energy provided to the actuation fibers for control of the deflection.
FILED	Tuesday, September 24, 2013
APPL NO	14/034767
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 10/04 (20130101) A61B 10/0275 (20130101) Original (OR) Class A61B 17/3421 (20130101) A61B 2010/045 (20130101) A61B 2017/003 (20130101)
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10675138 — Scaffolds for soft tissue and uses thereof

US 10675138	Schwartz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE) Division of Materials Research (DMR)
APPLICANT(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
INVENTOR(S)	Jeffrey Schwartz (Princeton, New Jersey); Jean E. Schwarzbauer (Princeton, New Jersey); Casey M. Jones (Portland, Oregon); Patrick E. Donnelly (Lawrenceville, New Jersey); Stephen B. Bandini (Newton, Massachusetts); Shivani Singh (El Cerrito, California)
ABSTRACT	The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair and transplantation.
FILED	Monday, October 05, 2015
APPL NO	14/875168
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/0077 (20130101) Original (OR) Class A61F 2/30771 (20130101) A61F 2002/0081 (20130101) A61F 2002/0086 (20130101) A61F 2002/3084 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/02 (20130101) A61L 27/06 (20130101) A61L 27/10 (20130101) A61L 27/16 (20130101) A61L 27/24 (20130101) A61L 27/047 (20130101) A61L 27/227 (20130101) A61L 27/306 (20130101) A61L 27/383 (20130101) A61L 27/3633 (20130101) A61L 27/3834 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 2533/10 (20130101) C12N 2533/12 (20130101) C12N 2533/30 (20130101) C12N 2533/90 (20130101) C12N 2535/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/405 (20130101)
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10675362 — Photoluminescent nanoparticles and their uses in detection or quantification of singlet oxygen

US 10675362	Thomas, III et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Trustees of Tufts College (Medford, Massachusetts)
ASSIGNEE(S)	Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S)	Samuel W. Thomas, III (Middleton, Massachusetts); Fanny Frausto (Somerville, Massachusetts); Jingjing Zhang (Willowbrook, Illinois)
ABSTRACT	A composition, as well as methods using the composition, for detection or quantification of a molecule at a singlet state (e.g., singlet oxygen). The composition includes one or more nanoparticles, and the nanoparticle has an energy donor, an energy acceptor associated with the energy donor, and an energy transfer mechanism between the energy donor and the energy acceptor.
FILED	Tuesday, August 01, 2017
APPL NO	15/665902
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 41/0057 (20130101) A61K 47/64 (20170801) A61K 49/0021 (20130101) Original (OR) Class A61K 49/0093 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/84 (20130101) G01N 33/542 (20130101) G01N 33/582 (20130101) G01N 33/587 (20130101)
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10675364 — Rhodol fluorophores for near-infrared imaging

US 10675364	Hettie et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California); THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California); THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri)
INVENTOR(S)	Kenneth Hettie (Stanford, California); Jessica Klockow (Stanford, California); Timothy Glass (Columbia, Missouri); Frederick T. Chin (Standford, California)
ABSTRACT	The present disclosure encompasses embodiments of a novel near-infrared-emitting molecular fluorophore and probes incorporating said fluorophore advantageous for in vitro and in vivo research studies. The fluorophore is robust, photostable, and possesses functionalities for easy bioorthogonal conjugation (e.g., click chemistry, hydrazone formation, Diels Alder, Staudinger ligation, etc.). It is biocompatible and emits at 711 nm in aqueous conditions. These fluorophores may be used to fluorescently tag biological molecules or structures of interest, or used as optical reporters (i.e., activatable molecular probes, fluorescent dyes) for specific biomarkers/analytes as they can be switched from “off” to “on.” This fluorophore is useful for cellular assays and preclinical small animal imaging as the near-infrared emission is highly penetrating, and the photophysical properties are outstanding. As such, the properties of this class of fluorophores could easily be translated for use in clinical applications.
FILED	Thursday, June 23, 2016
APPL NO	15/738327
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0043 (20130101) Original (OR) Class A61K 49/0058 (20130101) Heterocyclic Compounds C07D 491/052 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 2458/00 (20130101)
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10676406 — Hopanoids producing bacteria and related biofertilizers, compositions, methods and systems

US 10676406	Newman et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Dianne K. Newman (Pasadena, California); Gargi Kulkarni (Pasadena, California); Brittany Jo Belin (Pasadena, California); Eric Giraud (Marseilles, France); Antonio Molinaro (Naples, Italy); Alba Silipo (Naples, Italy)
ABSTRACT	Hopanoids, hopanoids-producing nitrogen-fixing bacteria, and related formulations, systems and methods are described herein. In particular, hopanoids alone or in combination with hopanoid-producing nitrogen-fixing bacteria can be used as biofertilizer to stimulate plant growth and yield with enhanced tolerance to diverse stresses found in plant-microbe symbiotic microenvironments.
FILED	Tuesday, October 09, 2018
APPL NO	16/155719
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/00 (20130101) Organic Fertilisers Not Covered by Subclasses C05B, C05C, e.g Fertilisers From Waste or Refuse C05F 11/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/20 (20130101) C12N 15/52 (20130101) C12N 15/82 (20130101) Enzymes C12Y 402/01084 (20130101)
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10676598 — Activated isobutylene-isoprene rubber and thermoset rubber therefrom

US 10676598	Jia et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Li Jia (Hudson, Ohio); Yu Sun (Cuyahoga Falls, Ohio); Mara Kuenen (Middlesex, New York)
ASSIGNEE(S)	THE UNIVERSITY OF AKRON (Akron, Ohio)
INVENTOR(S)	Li Jia (Hudson, Ohio); Yu Sun (Cuyahoga Falls, Ohio); Mara Kuenen (Middlesex, New York)
ABSTRACT	In one or more embodiments, the present invention provides an way to modify the isoprene unit using an alder-ene reaction to form thermoset compounds comprising the resultant electron-deficient, readily crosslinkable polyisobutylene-based rubber that avoids the use of corrosive bromine or chlorine to make the activated butyl rubber, is easier to crosslink than the halobutyls, allows crosslinking with a simple organic base or a peroxide, and has mechanical properties as good as or better than sulfur crosslinked butyl rubbers.
FILED	Thursday, August 02, 2018
APPL NO	16/053048
ART UNIT	1764 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Treatment or Chemical Modification of Rubbers C08C 19/28 (20130101) Compositions of Macromolecular Compounds C08L 9/00 (20130101) Original (OR) Class
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10677722 — Photothermal imaging device and system

US 10677722	Li et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Notre Dame du Lac (South Bend, Indiana)
ASSIGNEE(S)	University of Notre Dame du Lac (South Bend, Indiana)
INVENTOR(S)	Zhongming Li (Notre Dame, Indiana); Gregory Hartland (Granger, Indiana); Masaru Ken Kuno (Notre Dame, Indiana)
ABSTRACT	Mid-infrared photothermal heterodyne imaging (MIR-PHI) techniques described herein overcome the diffraction limit of traditional MIR imaging and uses visible photodiodes as detectors. MIR-PHI experiments are shown that achieve high sensitivity, sub-diffraction limit spatial resolution, and high acquisition speed. Sensitive, affordable, and widely applicable, photothermal imaging techniques described herein can serve as a useful imaging tool for biological systems and other submicron-scale applications.
FILED	Wednesday, April 05, 2017
APPL NO	15/480218
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/35 (20130101) G01N 21/171 (20130101) G01N 21/3563 (20130101) Original (OR) Class G01N 2021/1712 (20130101) G01N 2021/1714 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/02 (20130101) G01Q 60/34 (20130101)
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10677848 — Apparatus, circuit model, and method for battery modelling

US 10677848	Chow et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	TOTAL S.A. (Courbevoie, France); NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
ASSIGNEE(S)	TOTAL S.A. (Courbevoie, France); NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
INVENTOR(S)	Mo-Yuen Chow (Cary, North Carolina); Cong Sheng Huang (Raleigh, North Carolina); Carlos Carrejo (Paris, France)
ABSTRACT	A method and an apparatus for battery modelling. The method includes acquiring battery information from a sensor attached to a battery, the battery information including at least a terminal voltage and a load current; classifying, the battery information as effective data or ineffective data based on a phase of a battery cycle during which the battery information is acquired; identifying one or more parameters of the circuit model associated with the battery based on the effective data; and generating an estimation of a state of the battery using the circuit model having the one or more parameters identified using the effective data. Further, a circuit model is identified using effective data.
FILED	Friday, June 02, 2017
APPL NO	15/612548
ART UNIT	2857 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 31/367 (20190101) Original (OR) Class G01R 31/3842 (20190101) Electric Digital Data Processing G06F 30/367 (20200101) G06F 2119/06 (20200101)
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10678037 — Reverberation microscopy systems and methods

US 10678037	Mertz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)	Trustees of Boston University (Boston, Massachusetts)
INVENTOR(S)	Jerome Charles Mertz (Newton, Massachusetts); Devin Robert Beaulieu (Brookline, Massachusetts); Thomas Gary Bifano (Mansfield, Massachusetts)
ABSTRACT	A method for obtaining one or more images of a sample using a microscope includes dividing, using a reverberation cavity, a first one of a plurality of laser pulses into a plurality of sequential sub-pulses, each of the plurality of sequential sub-pulses having a power that is less than a previous one of the plurality of sequential sub-pulses, directing, using the one or more lenses of the microscope, the plurality of sequential sub-pulses onto a portion of the sample to generate a plurality of signals, each of the plurality of signals being associated with a different depth within the sample, and detecting the plurality of signals from the sample to generate one or more images of at least a portion of the sample.
FILED	Friday, July 12, 2019
APPL NO	16/510407
ART UNIT	2886 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6402 (20130101) G01N 21/6458 (20130101) G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) Original (OR) Class G02B 21/0048 (20130101) G02B 21/0076 (20130101)
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10678244 — Data synthesis for autonomous control systems

US 10678244	Iandola et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Tesla, Inc. (Palo Alto, California)
ASSIGNEE(S)	Tesla, Inc. (Palo Alto, California)
INVENTOR(S)	Forrest Nelson Iandola (San Jose, California); Donald Benton MacMillen (Hillsborough, California); Anting Shen (Berkeley, California); Harsimran Singh Sidhu (Fremont, California); Paras Jagdish Jain (Cupertino, California)
ABSTRACT	An autonomous control system generates synthetic data that reflect simulated environments. Specifically, the synthetic data is a representation of sensor data of the simulated environment from the perspective of one or more sensors. The system generates synthetic data by introducing one or more simulated modifications to sensor data captured by the sensors or by simulating the sensor data for a virtual environment. The autonomous control system uses the synthetic data to train computer models for various detection and control algorithms. In general, this allows autonomous control systems to augment training data to improve performance of computer models, simulate scenarios that are not included in existing training data, and/or train computer models that remove unwanted effects or occlusions from sensor data of the environment.
FILED	Friday, March 23, 2018
APPL NO	15/934899
ART UNIT	3668 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 11/04 (20130101) B60R 2300/301 (20130101) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 40/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) Original (OR) Class G05D 2201/0213 (20130101) Electric Digital Data Processing G06F 30/15 (20200101) G06F 30/20 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00805 (20130101) G06K 9/6257 (20130101) G06K 9/6268 (20130101)
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10679100 — Systems and methods for intelligently curating machine learning training data and improving machine learning model performance

US 10679100	Kang et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Clinc, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)	Clinc, Inc. (Ann Arbor, Michigan)
INVENTOR(S)	Yiping Kang (Ann Arbor, Michigan); Yunqi Zhang (Ann Arbor, Michigan); Jonathan K. Kummerfeld (Ann Arbor, Michigan); Parker Hill (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Jason Mars (Ann Arbor, Michigan)
ABSTRACT	Systems and methods of intelligent formation and acquisition of machine learning training data for implementing an artificially intelligent dialogue system includes constructing a corpora of machine learning test corpus that comprise a plurality of historical queries and commands sampled from production logs of a deployed dialogue system; configuring training data sourcing parameters to source a corpora of raw machine learning training data from remote sources of machine learning training data; calculating efficacy metrics of the corpora of raw machine learning training data, wherein calculating the efficacy metrics includes calculating one or more of a coverage metric value and a diversity metric value of the corpora of raw machine learning training data; using the corpora of raw machine learning training data to train the at least one machine learning classifier if the calculated coverage metric value of the corpora of machine learning training data satisfies a minimum coverage metric threshold.
FILED	Wednesday, April 10, 2019
APPL NO	16/379978
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 16/3329 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101)
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10679150 — Systems and methods for automatically configuring training data for training machine learning models of a machine learning-based dialogue system including seeding training samples or curating a corpus of training data based on instances of training data identified as anomalous

US 10679150	Larson et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Clinc, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)	Clinc, Inc. (Ann Arbor, Michigan)
INVENTOR(S)	Stefan Larson (Ann Arbor, Michigan); Anish Mahendran (Ann Arbor, Michigan); Andrew Lee (Ann Arbor, Michigan); Jonathan K. Kummerfeld (Ann Arbor, Michigan); Parker Hill (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Jason Mars (Ann Arbor, Michigan)
ABSTRACT	A system and method for improving a machine learning-based dialogue system includes: sourcing a corpus of raw machine learning training data from sources of training data based on a plurality of seed training samples, wherein the corpus of raw machine learning training data comprises a plurality of distinct instances of training data; generating a vector representation for each distinct instance of training data; identifying statistical characteristics of the corpus of raw machine learning training data based on a mapping of the vector representation for each distinct instance of training data; identifying anomalous instances of the plurality of distinct instances of training data of the corpus of raw machine learning training data based on the identified statistical characteristics of the corpus; and curating the corpus of raw machine learning training data based on each of the instances of training data identified as anomalous instances.
FILED	Wednesday, November 20, 2019
APPL NO	16/689287
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 17/18 (20130101) G06F 40/279 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) G06K 9/6262 (20130101) G06K 9/6272 (20130101) Computer Systems Based on Specific Computational Models G06N 20/10 (20190101) Original (OR) Class
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10679347 — Systems and methods for ultrasound imaging

US 10679347	Mauldin, Jr. et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	Rivanna Medical LLC (Charlottesville, Virginia)
ASSIGNEE(S)	Rivanna Medical LLC (Charlottesville, Virginia)
INVENTOR(S)	Frank William Mauldin, Jr. (Charlottesville, Virginia); Kevin Owen (Crozet, Virginia)
ABSTRACT	In some embodiments, a method comprises: obtaining a 2D ultrasound image of an imaged region of a subject, the imaged region comprising bone; identifying model template cross-sections of a 3D model of the bone corresponding to the 2D image at least in part by registering the 2D ultrasound image to the 3D model, wherein the model template cross-sections are defined prior to obtaining such 2D image, the model template cross-sections having size and shape representative of a population of potential subjects; identifying at least one location of at least one landmark feature of the bone in the 2D image based on results of the registration; and generating a visualization that includes: a visualization of the 2D image and a visualization of one of the identified cross-sections of the 3D model, wherein the visualization indicates the at least one location of the at least one landmark feature.
FILED	Thursday, June 14, 2018
APPL NO	16/008743
ART UNIT	2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/461 (20130101) A61B 8/0858 (20130101) A61B 8/0875 (20130101) A61B 8/5223 (20130101) A61B 8/5246 (20130101) A61B 8/5269 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/52 (20130101) G06K 9/4661 (20130101) G06K 2009/4666 (20130101) Image Data Processing or Generation, in General G06T 5/009 (20130101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/30 (20170101) G06T 11/60 (20130101) G06T 15/08 (20130101) G06T 2200/04 (20130101) G06T 2207/10132 (20130101) G06T 2207/30008 (20130101)
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10679755 — Methods, systems, and computer readable media for data analysis and inference of particle diffusion in target materials and target material simulants

US 10679755	Forest et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Mathematical Sciences (DMS)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)	THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina)
INVENTOR(S)	Mark Gregory Forest (Chapel Hill, North Carolina); John William Mellnik (Carrboro, North Carolina); Paula Andrea Vasquez (Chapel Hill, North Carolina); David Brooks Hill (Burlington, North Carolina); Scott Alister McKinley (Gainesville, Florida)
ABSTRACT	Methods, systems, and computer readable media for data analysis and inference of particle diffusion in mucus barriers and generic permeable biomaterials are disclosed. According to one aspect, the subject matter described herein includes a method for data analysis and inference of particle diffusion in target materials, such as mucus barriers, or their simulants. The method includes collecting experimental data of observed particle movement through samples of a target material or simulant (“the target”), analyzing the collected data to determine the stochastic diffusive process that is being observed for particular particles in the particular sample, using one or more of the observed stochastic diffusive processes to simulate the diffusion of particles through layers of the target of various thicknesses, using the simulation results to determine how passage time scales according to thickness of the target, and verifying the simulation results.
FILED	Thursday, January 23, 2014
APPL NO	14/762657
ART UNIT	2128 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 17/16 (20130101) G06F 19/00 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/28 (20130101) G09B 23/30 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101) Original (OR) Class
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10679765 — Thermoplastic carbon composite electrodes

US 10679765	Henry et al.
FUNDED BY	Department of Health and Human Services (HHS) Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) National Science Foundation (NSF)
APPLICANT(S)	Colorado State University Research Foundation (Fort Collins, Colorado)
ASSIGNEE(S)	Colorado State University Research Foundation (Fort Collins, Colorado)
INVENTOR(S)	Charles S. Henry (Fort Collins, Colorado); Kevin Klunder (Fort Collins, Colorado)
ABSTRACT	A new solvent-based method is presented for making low-cost composite graphite electrodes containing a thermoplastic binder. The electrodes, termed thermoplastic electrodes (TPEs), are easy to fabricate and pattern, give excellent electrochemical performance, and have high conductivity (1500 S m⁻¹). The thermoplastic binder enables the electrodes to be hot embossed, molded, templated, and/or cut with a CO₂laser into a variety of intricate patterns. These electrodes show a marked improvement in peak current, peak separation, and resistance to charge transfer over traditional carbon electrodes. The impact of electrode composition, surface treatment (sanding, polishing, plasma treatment), and graphite source were found to impact fabrication, patterning, conductivity, and electrochemical performance. Under optimized conditions, electrodes generated responses similar to more expensive and difficult to fabricate graphene and highly oriented pyrolytic graphite electrodes. These TPE electrodes provide an approach for fabricating high-performance carbon electrodes with applications ranging from sensing to batteries.
FILED	Tuesday, August 06, 2019
APPL NO	16/533259
ART UNIT	1781 — Miscellaneous Articles, Stock Material
CURRENT CPC	Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/24 (20130101) Original (OR) Class H01B 13/0036 (20130101)
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10680193 — Photoelectric cells incorporating wrinkles and folds to enhance efficiency and bendability and method of making

US 10680193	Loo et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Yueh-Lin Loo (Princeton, New Jersey); Jongbok Kim (Princeton, New Jersey); Pilnam Kim (Daejeon, South Korea); Howard Stone (Princeton, New Jersey); Nicolas Pegard (Princeton, New Jersey); Jason Fleischer (Princeton, New Jersey)
ASSIGNEE(S)	THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
INVENTOR(S)	Yueh-Lin Loo (Princeton, New Jersey); Jongbok Kim (Princeton, New Jersey); Pilnam Kim (Daejeon, South Korea); Howard Stone (Princeton, New Jersey); Nicolas Pegard (Princeton, New Jersey); Jason Fleischer (Princeton, New Jersey)
ABSTRACT	A photovoltaic cell and method of making are disclosed. The photovoltaic cell includes a substrate having a surface at least partially covered in wrinkles and folds, the folds dividing the surface into a plurality of domains. A photoactive layer is formed on the substrate. At least one transparent electrode is coupled to the photoactive layer and configured to allow transmission of light into the photoactive layer. The domains may have a wrinkle periodicity of less than 2 μm. The folds may have a fold density of less than 0.25. The transport layer may comprise PEDOT:PSS. The photoactive layer may comprise P3HT:PCBM. The photoactive layer may comprise a bulk heterojunction.
FILED	Friday, March 14, 2014
APPL NO	14/214564
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0037 (20130101) H01L 51/0097 (20130101) H01L 51/447 (20130101) Original (OR) Class H01L 51/4253 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101)
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10680403 — Bulk direct gap MoS2 by plasma induced layer decoupling

US 10680403	Cronin et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF)
APPLICANT(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California); REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	University of Southern California (Los Angeles, California); The Regents of the University of California (Oakland, California)
INVENTOR(S)	Stephen B. Cronin (South Pasadena, California); Rohan Dhall (Los Angeles, California); Roger Lake (Riverside, California); Zhen Li (Los Angeles, California); Mahesh Neupane (Riverside, California); Darshana Wickramaratne (Riverside, California)
ABSTRACT	Bulk direct transition metal dichalcogenide (TMDC) may have an increased interlayer separation of at least 0.5, 1, or 3 angstroms more than its bulk value. The TMDC may be a bulk direct band gap molybdenum disulfide (MoS2) or a bulk direct band gap tungsten diselenide (WSe₂). Oxygen may be between the interlayers. A device may include the TMDC, such as an optoelectronic device, such as an LED, solid state laser, a photodetector, a solar cell, a FET, a thermoelectric generator, or a thermoelectric cooler. A method of making bulk direct transition metal dichalcogenide (TMDC) with increased interlayer separation may include exposing bulk direct TMDC to a remote (aka downstream) oxygen plasma. The plasma exposure may cause an increase in the photoluminescence efficiency of the TMDC, more charge neutral doping, or longer photo-excited carrier lifetimes, as compared to the TMDC without the plasma exposure.
FILED	Wednesday, December 16, 2015
APPL NO	15/536628
ART UNIT	1761 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 2204/28 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/06 (20130101) C01G 41/00 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/06 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/032 (20130101) H01L 33/26 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/0612 (20130101) H01S 5/02415 (20130101) Original (OR) Class H01S 5/02453 (20130101)
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10680508 — Control to output dynamic response and extend modulation index range with hybrid selective harmonic current mitigation-PWM and phase-shift PWM for four-quadrant cascaded H-bridge converters

US 10680508	Wang et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Shuo Wang (Gainesville, Florida); Hui Zhao (Cambridge, United Kingdom); Amirhossein Moeini (Rolla, Missouri)
ABSTRACT	A hybrid Cascaded H-Bridge (CHB) converter includes a selective harmonic current mitigation pulse width modulation (SHCM-PWM) unit coupled to an input current and providing an output signal SW_SHCM, a phase shift pulse width modulation (PSPWM) unit coupled to the input current and providing an output signal SW_PS, a modulation selector coupled to the output signal SW_SHCMof the SHCM-PWM unit and the output signal SW_PSof the PSPWM unit and providing an output signal SW, and a CHB converter coupled to the output signal SW of the modulation selector. The modulation selector can select one of the output signals (SW_SHCMand SW_PS) as the output signal SW based on the input current. The hybrid technique is for cascaded multilevel converters which utilizes asymmetric SHCM to mitigate the harmonics generated from PS-PWM to meet harmonic limits with a smaller number of switching transitions and smaller inductance than the conventional PS-PWM technique.
FILED	Thursday, February 07, 2019
APPL NO	16/270180
ART UNIT	2838 — Electrical Circuits and Systems
CURRENT CPC	Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/12 (20130101) Original (OR) Class H02M 3/1584 (20130101) H02M 3/1588 (20130101) H02M 2003/1586 (20130101)
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10680553 — Scalable terahertz phased array and method

US 10680553	Tousi et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	Cornell University (Ithaca, New York)
ASSIGNEE(S)	Cornell University (Ithaca, New York)
INVENTOR(S)	Yahya Tousi (San Jose, California); Ehsan Afshari (Ithaca, New York)
ABSTRACT	A device and method for terahertz signal generation are disclosed. Oscillators are arranged in a two-dimensional array, each oscillator connected to a corresponding antenna. Each oscillator is unidirectional connected to its adjacent oscillators by a phase shifter. A method for generating a steerable terahertz signal utilizes an array of oscillators connected by corresponding phase shifters. A terahertz signal having a fundamental frequency is generated using the array. The phase shift of one or more of the phase shifters is varied in order to vary the fundamental frequency and/or steer the signal generated by the array.
FILED	Monday, February 09, 2015
APPL NO	15/117060
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 3/36 (20130101) H01Q 9/0407 (20130101) H01Q 21/0025 (20130101) H01Q 21/245 (20130101) Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 5/24 (20130101) Original (OR) Class H03B 5/1212 (20130101) H03B 2200/0084 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/20 (20130101) H04L 49/101 (20130101)
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10680797 — Security-adaptive voltage conversion as a lightweight counter measure against LPA attacks

US 10680797	Kose et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Selcuk Kose (Tampa, Florida); Weize Yu (Tampa, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida)
INVENTOR(S)	Selcuk Kose (Tampa, Florida); Weize Yu (Tampa, Florida)
ABSTRACT	Methods and systems are provided for a security adaptive (SA) voltage converter that receives input power from a power source and provides power to a cryptographic system. The SA voltage converter triggers countermeasures against leakage power analysis (LPA) attacks that slow down an operating frequency of the cryptographic circuit. When an LPA attack is detected, a discharging resistor sinks redundant current to alter the signature of load power dissipation of at the input to the SA voltage converter system. The SA voltage converter includes a converter reshuffling converter. The power dissipation induced by the discharging resistor, as measured at the input received from the power source, is scrambled by the SA voltage converter to increase noise inserted into the input power and to alter the power profile that is measured for the cryptographic circuit.
FILED	Monday, April 30, 2018
APPL NO	15/967254
ART UNIT	2494 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/602 (20130101) G06F 21/755 (20170801) Pulse Technique H03K 19/0019 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/003 (20130101) Original (OR) Class H04L 9/0618 (20130101)
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National Aeronautics and Space Administration (NASA)

10675781 — Shape memory alloy rock splitters (SMARS)

US 10675781	Benafan et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	U.S.A. as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as Represented by the Administrator of National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Othmane Benafan (Fairview Park, Ohio); Ronald D. Noebe (Medina, Ohio)
ABSTRACT	Shape memory alloys (SMAs) may be used for static rock splitting. The SMAs may be used as high-energy multifunctional materials, which have a unique ability to recover large deformations and generate high stresses in response to thermal loads.
FILED	Tuesday, April 04, 2017
APPL NO	15/478918
ART UNIT	3723 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Working Stone or Stone-like Materials B28D 1/322 (20130101) B28D 1/327 (20130101) Original (OR) Class
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10676374 — Ammonia capture and recovery system and method for removing ammonia from a wastewater stream

US 10676374	Lunn et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as Represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as Represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Griffin M. Lunn (Cocoa Beach, Florida); Andrew F. Gleich (Jacksonville, Florida); Oscar A. Monje (Merritt Island, Florida); Julia M. Worrell (New Franklin, Ohio)
ABSTRACT	A wastewater stream including ammonia and water is fed to at least one packed column including packing material having a surface of solid magnesium phosphate or solid magnesium ammonium phosphate or both. Each of the packed columns is capable of cycling between an ammonia absorption operation and an ammonia regeneration operation. The magnesium phosphate compound reacts with the water and ammonia to form a magnesium ammonium phosphate compound. In one embodiment, this system provides for the regeneration of the magnesium ammonium phosphate compound for further use as an ammonia sorber. In another embodiment, the magnesium ammonium phosphate compound is used as fertilizer. Additionally, the ammonia capture and recovery system may be used in conjunction with other unit operations in an overall wastewater treatment system.
FILED	Tuesday, June 27, 2017
APPL NO	15/635011
ART UNIT	1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/281 (20130101) Original (OR) Class C02F 2101/16 (20130101) C02F 2209/03 (20130101) C02F 2209/06 (20130101) C02F 2209/40 (20130101) C02F 2209/44 (20130101) C02F 2303/16 (20130101)
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10676406 — Hopanoids producing bacteria and related biofertilizers, compositions, methods and systems

US 10676406	Newman et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Dianne K. Newman (Pasadena, California); Gargi Kulkarni (Pasadena, California); Brittany Jo Belin (Pasadena, California); Eric Giraud (Marseilles, France); Antonio Molinaro (Naples, Italy); Alba Silipo (Naples, Italy)
ABSTRACT	Hopanoids, hopanoids-producing nitrogen-fixing bacteria, and related formulations, systems and methods are described herein. In particular, hopanoids alone or in combination with hopanoid-producing nitrogen-fixing bacteria can be used as biofertilizer to stimulate plant growth and yield with enhanced tolerance to diverse stresses found in plant-microbe symbiotic microenvironments.
FILED	Tuesday, October 09, 2018
APPL NO	16/155719
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/00 (20130101) Organic Fertilisers Not Covered by Subclasses C05B, C05C, e.g Fertilisers From Waste or Refuse C05F 11/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/20 (20130101) C12N 15/52 (20130101) C12N 15/82 (20130101) Enzymes C12Y 402/01084 (20130101)
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10677741 — Laser surface treatment and spectroscopic analysis system

US 10677741	Connell et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as Represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	John W. Connell (Yorktown, Virginia); Frank L. Palmieri (Hampton, Virginia); William T. Yost (Newport News, Virginia); John W. Hopkins (Suffolk, Virginia); Rodolfo I Ledesma (Hampton, Virginia)
ABSTRACT	Systems, methods, and devices of the various embodiments may enable simultaneous preparation of a substrate for adhesive bonding and detection of minute contaminants on the substrate. Various embodiments may enable detection of contaminants on a surface of a substrate while the surface of the substrate is being prepared for adhesive bonding by laser ablation. Various embodiments may provide an integrated laser treatment and measurement system.
FILED	Tuesday, July 31, 2018
APPL NO	16/050319
ART UNIT	2877 — Optics
CURRENT CPC	Cleaning in General; Prevention of Fouling in General B08B 7/0042 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/50 (20151001) B23K 26/127 (20130101) B23K 26/0622 (20151001) B23K 26/0884 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/443 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/94 (20130101) Original (OR) Class G01N 21/718 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/0037 (20130101)
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10680345 — High-efficiency dual-band circularly-polarized antenna for harsh environment for telecommunication

US 10680345	Chahat et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Nacer E. Chahat (Pasadena, California); Polly Estabrook (Pasadena, California); Brant T. Cook (Pasadena, California)
ABSTRACT	An antenna for dual-band or wide-band communication link. The antenna includes a patch array, arranged above a top ground plane, that includes one or more panels, each panel included one or more patch subarrays, and each patch subarray includes single patch elements made from metal. Each patch element includes: a flat rectangular radiation surface element into which a rectangular cutout is formed; an RF power feed point having a cylindrical shape that makes contact to the bottom side of the radiation surface element and feeds through a hole formed in the top ground plane for connection to the RF power; and a structural post having a cylindrical shape that contacts, at one end, the bottom side of the radiation surface element at a region of the radiation surface element where electric surface current is substantially smaller than any other region, and contacts the top ground plane at a second end.
FILED	Monday, December 17, 2018
APPL NO	16/223070
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/002 (20130101) H01Q 9/045 (20130101) H01Q 9/0421 (20130101) H01Q 9/0428 (20130101) H01Q 21/0025 (20130101) H01Q 21/065 (20130101) Original (OR) Class
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10681837 — Spacecube V2.0 flight card mechanical system

US 10681837	Davis et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Milton C. Davis (Upper Marlboro, Maryland); David J. Petrick (Severna Park, Maryland)
ABSTRACT	An electronic assembly support system includes a frame having a plurality of side rails side rails to be positioned along a longitudinal axis of an electronic assembly, a plurality of cross rails connected between the side rails, positioned to surround predetermined components of the electronic assembly, and a first fastener interface for attaching the plurality of side rails and cross rails to the electronic assembly.
FILED	Friday, September 28, 2018
APPL NO	16/145802
ART UNIT	2835 — Electrical Circuits and Systems
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/66 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 5/0204 (20130101) H05K 7/18 (20130101) Original (OR) Class
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National Security Agency (NSA)

10677881 — Map assisted inertial navigation

US 10677881	Magid
FUNDED BY	National Security Agency (NSA)
APPLICANT(S)	The Government of the United States as represented by the Director, National Security Agency (Fort George G. Meade, Maryland)
ASSIGNEE(S)	Government of the United States as represented by Director National Security Agency (, None)
INVENTOR(S)	Aaron D. Magid (Elkridge, Maryland)
ABSTRACT	The present invention provides an improved method of pedestrian dead reckoning (PDR) and device for performing PDR. An image of the environment to be traversed by the pedestrian is used to define states associated with the PDR environment. The image is utilized to constrain error in the estimated location of the pedestrian. Pairs of states are identified and the characteristics of the defined states are utilized to define the probabilities of transitioning between states of the pair. Possible pedestrian events which may be observed are also defined and for each pair of states, the possibility of detecting an event given the state transition is determined. After detecting a series of events, the transition probabilities and the event probabilities are utilized to determine a state probability that the pedestrian is in a particular state at each particular time. Utilizing these state probabilities an estimated location is provided at each time.
FILED	Tuesday, March 29, 2016
APPL NO	15/083602
ART UNIT	2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/00 (20130101) G01C 21/206 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0257 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/029 (20180201) H04W 4/33 (20180201)
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10678724 — Apparatuses, methods, and systems for in-network storage in a configurable spatial accelerator

US 10678724	ChoFleming et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)	Intel Corporation (Santa Clara, California)
INVENTOR(S)	Kermin ChoFleming (Hudson, Massachusetts); Simon Steely, Jr. (Hudson, New Hampshire); Kent Glossop (Nashua, New Hampshire)
ABSTRACT	Systems, methods, and apparatuses relating to in-network storage for a configurable spatial accelerator are described. In one embodiment, a configurable spatial accelerator includes a plurality of processing elements; a circuit switched interconnect network between the plurality of processing elements to receive an input of a dataflow graph comprising a plurality of nodes, wherein the dataflow graph is to be overlaid into the circuit switched interconnect network and the plurality of processing elements with each node represented as a dataflow operator in the plurality of processing elements, and the plurality of processing elements are to perform an operation by a respective, incoming operand set arriving at each of the dataflow operators of the plurality of processing elements; and an in-network storage element of the circuit switched interconnect network comprising a queue coupled to an output queue of a first processing element, and a controller that switches the in-network storage element into a first mode that provides a value stored in the queue of the in-network storage element by the output queue of the first processing element to an input queue of a second processing element when a configuration value is a first value, and into a second mode that bypasses the queue of the in-network storage element and provides a value from the output queue of the first processing element to the input queue of the second processing element when the configuration value is a second value.
FILED	Saturday, December 29, 2018
APPL NO	16/236423
ART UNIT	2184 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 13/24 (20130101) Original (OR) Class G06F 2213/24 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 49/15 (20130101) H04L 67/1097 (20130101)
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10680131 — Doped absorption devices

US 10680131	Huang et al.
FUNDED BY	National Security Agency (NSA) Maryland Procurement Office (MPO)
APPLICANT(S)	HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	Zhihong Huang (Palo Alto, California); Raymond G Beausoleil (Seattle, Washington)
ABSTRACT	An example device includes a doped absorption region to receive optical energy and generate free electrons from the received optical energy. The example device also includes a doped charge region to increase an electric field. The example device also includes an intrinsic multiplication region to generate additional free electrons from impact ionization of the generated free electrons. The example device includes a doped contact region to conduct the free electrons and the additional free electrons.
FILED	Monday, July 27, 2015
APPL NO	15/747760
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/12 (20130101) G02B 6/12004 (20130101) G02B 2006/12061 (20130101) G02B 2006/12123 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/028 (20130101) H01L 31/105 (20130101) H01L 31/109 (20130101) Original (OR) Class H01L 31/1075 (20130101) H01L 31/1804 (20130101) H01L 31/02327 (20130101)
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10680407 — Multi-wavelength semiconductor comb lasers

US 10680407	Kurczveil et al.
FUNDED BY	National Security Agency (NSA) Maryland Procurement Office (MPO)
APPLICANT(S)	HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	Geza Kurczveil (Palo Alto, California); Di Liang (Palo Alto, California); Raymond G. Beausoleil (Palo Alto, California)
ABSTRACT	Examples disclosed herein relate to multi-wavelength semiconductor comb lasers. In some examples disclosed herein, a multi-wavelength semiconductor comb laser may include a waveguide included in an upper silicon layer of a silicon-on-insulator (SOI) substrate. The comb laser may include a quantum dot (QD) active gain region above the SOI substrate defining an active section in a laser cavity of the comb laser and a dispersion tuning section included in the laser cavity to tune total cavity dispersion of the comb laser.
FILED	Monday, April 10, 2017
APPL NO	15/483678
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/106 (20130101) H01S 5/14 (20130101) H01S 5/021 (20130101) H01S 5/026 (20130101) H01S 5/068 (20130101) H01S 5/142 (20130101) H01S 5/0651 (20130101) H01S 5/1014 (20130101) H01S 5/1032 (20130101) Original (OR) Class H01S 5/1039 (20130101) H01S 5/1071 (20130101) H01S 5/1096 (20130101) H01S 5/3412 (20130101)
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10680408 — Quantum dot comb lasers with external cavity

US 10680408	Kurczveil et al.
FUNDED BY	National Security Agency (NSA)
APPLICANT(S)	HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	Geza Kurczveil (Santa Barbara, California); Chong Zhang (Santa Barbara, California); Di Liang (Santa Barbara, California); Raymond G. Beausoleil (Palo Alto, California)
ABSTRACT	A quantum dot comb laser includes a body defining a lasing cavity and an extension defining an external cavity, the FSR of the lasing cavity being an inverse of an integer multiple of the FSR of the external cavity.
FILED	Wednesday, August 22, 2018
APPL NO	16/108399
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/50 (20130101) H01S 5/146 (20130101) H01S 5/0228 (20130101) H01S 5/0651 (20130101) H01S 5/1003 (20130101) H01S 5/1071 (20130101) H01S 5/1096 (20130101) Original (OR) Class H01S 5/3412 (20130101) H01S 5/34313 (20130101)
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10680591 — Programmable resistive delay

US 10680591	Schiller et al.
FUNDED BY	National Security Agency (NSA)
APPLICANT(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	Chris Schiller (Ft. Collins, Colorado); Adam Johnson (Ft. Collins, Colorado)
ABSTRACT	An example delay circuit is described that includes an input node to receive a first signal, a first circuit path, a second circuit path, an output buffer, and an output node. The first circuit path includes at least one first buffer and a first array of switches. The second circuit path includes at least one second buffer and a second array of switches. The output buffer receives a mixed output of the first circuit path and the second circuit path. The output node transmits a second signal equivalent to the first signal with a programmed delay.
FILED	Monday, April 02, 2018
APPL NO	15/942797
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Pulse Technique H03K 5/134 (20140701) Original (OR) Class H03K 2005/00019 (20130101) H03K 2005/00195 (20130101)
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Small Business Administration (SBA)

10675008 — Steerable biopsy needle

US 10675008	Ryu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Seok Chang Ryu (Stanford, California); Mark Cutkosky (Palo Alto, California); Richard J. Black (Menlo Park, California); Joannes Mario Costa (Rancho La Costa, California); Behzad Moslehi (Los Altos, California); Fereydoun Faridian (Atherton, California); Levy Oblea (Union City, California); Vahid Sotoudeh (Los Altos, California)
ASSIGNEE(S)	Intelligent Fiber Optic Systems, Inc. (San Jose, California)
INVENTOR(S)	Seok Chang Ryu (Stanford, California); Mark Cutkosky (Palo Alto, California); Richard J. Black (Menlo Park, California); Joannes Mario Costa (Rancho La Costa, California); Behzad Moslehi (Los Altos, California); Fereydoun Faridian (Atherton, California); Levy Oblea (Union City, California); Vahid Sotoudeh (Los Altos, California)
ABSTRACT	A biopsy needle has a cylindrical shell outer cannula and a stylet consisting of an inner stylet and outer stylet, both of which are inserted into the cylindrical cannula. The outer stylet has a series of strain relieved slits which provide bending over a deflection region in one direction, and the outer stylet is formed from a material such as a shape memory alloy (SMA) having a superelastic phase. The deflection is generated by an SMA wire spanning a deflection extent and attached to the outer stylet on either side of the deflection extent. The inner stylet, when positioned inside the outer stylet, has one or more actuation fibers which couple optical energy into the SMA wire, causing a deflection of the outer stylet over the deflection extent, with the optical energy provided to the actuation fibers for control of the deflection.
FILED	Tuesday, September 24, 2013
APPL NO	14/034767
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 10/04 (20130101) A61B 10/0275 (20130101) Original (OR) Class A61B 17/3421 (20130101) A61B 2010/045 (20130101) A61B 2017/003 (20130101)
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10678244 — Data synthesis for autonomous control systems

US 10678244	Iandola et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Tesla, Inc. (Palo Alto, California)
ASSIGNEE(S)	Tesla, Inc. (Palo Alto, California)
INVENTOR(S)	Forrest Nelson Iandola (San Jose, California); Donald Benton MacMillen (Hillsborough, California); Anting Shen (Berkeley, California); Harsimran Singh Sidhu (Fremont, California); Paras Jagdish Jain (Cupertino, California)
ABSTRACT	An autonomous control system generates synthetic data that reflect simulated environments. Specifically, the synthetic data is a representation of sensor data of the simulated environment from the perspective of one or more sensors. The system generates synthetic data by introducing one or more simulated modifications to sensor data captured by the sensors or by simulating the sensor data for a virtual environment. The autonomous control system uses the synthetic data to train computer models for various detection and control algorithms. In general, this allows autonomous control systems to augment training data to improve performance of computer models, simulate scenarios that are not included in existing training data, and/or train computer models that remove unwanted effects or occlusions from sensor data of the environment.
FILED	Friday, March 23, 2018
APPL NO	15/934899
ART UNIT	3668 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 11/04 (20130101) B60R 2300/301 (20130101) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 40/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) Original (OR) Class G05D 2201/0213 (20130101) Electric Digital Data Processing G06F 30/15 (20200101) G06F 30/20 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00805 (20130101) G06K 9/6257 (20130101) G06K 9/6268 (20130101)
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10679100 — Systems and methods for intelligently curating machine learning training data and improving machine learning model performance

US 10679100	Kang et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Clinc, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)	Clinc, Inc. (Ann Arbor, Michigan)
INVENTOR(S)	Yiping Kang (Ann Arbor, Michigan); Yunqi Zhang (Ann Arbor, Michigan); Jonathan K. Kummerfeld (Ann Arbor, Michigan); Parker Hill (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Jason Mars (Ann Arbor, Michigan)
ABSTRACT	Systems and methods of intelligent formation and acquisition of machine learning training data for implementing an artificially intelligent dialogue system includes constructing a corpora of machine learning test corpus that comprise a plurality of historical queries and commands sampled from production logs of a deployed dialogue system; configuring training data sourcing parameters to source a corpora of raw machine learning training data from remote sources of machine learning training data; calculating efficacy metrics of the corpora of raw machine learning training data, wherein calculating the efficacy metrics includes calculating one or more of a coverage metric value and a diversity metric value of the corpora of raw machine learning training data; using the corpora of raw machine learning training data to train the at least one machine learning classifier if the calculated coverage metric value of the corpora of machine learning training data satisfies a minimum coverage metric threshold.
FILED	Wednesday, April 10, 2019
APPL NO	16/379978
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 16/3329 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101)
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10679150 — Systems and methods for automatically configuring training data for training machine learning models of a machine learning-based dialogue system including seeding training samples or curating a corpus of training data based on instances of training data identified as anomalous

US 10679150	Larson et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Clinc, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)	Clinc, Inc. (Ann Arbor, Michigan)
INVENTOR(S)	Stefan Larson (Ann Arbor, Michigan); Anish Mahendran (Ann Arbor, Michigan); Andrew Lee (Ann Arbor, Michigan); Jonathan K. Kummerfeld (Ann Arbor, Michigan); Parker Hill (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Jason Mars (Ann Arbor, Michigan)
ABSTRACT	A system and method for improving a machine learning-based dialogue system includes: sourcing a corpus of raw machine learning training data from sources of training data based on a plurality of seed training samples, wherein the corpus of raw machine learning training data comprises a plurality of distinct instances of training data; generating a vector representation for each distinct instance of training data; identifying statistical characteristics of the corpus of raw machine learning training data based on a mapping of the vector representation for each distinct instance of training data; identifying anomalous instances of the plurality of distinct instances of training data of the corpus of raw machine learning training data based on the identified statistical characteristics of the corpus; and curating the corpus of raw machine learning training data based on each of the instances of training data identified as anomalous instances.
FILED	Wednesday, November 20, 2019
APPL NO	16/689287
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 17/18 (20130101) G06F 40/279 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) G06K 9/6262 (20130101) G06K 9/6272 (20130101) Computer Systems Based on Specific Computational Models G06N 20/10 (20190101) Original (OR) Class
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10679488 — System and method for improving compliance with one or more protocols including hand hygiene and personal protective equipment protocols

US 10679488	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Nursing Research (NINR) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Microsensor Labs, LLC (Chicago, Illinois)
ASSIGNEE(S)	Microsensor Labs, LLC (Chicago, Illinois)
INVENTOR(S)	Peng Liu (Chicago, Illinois); Yang Liu (Beijing, China PRC); Jiapeng Huang (Louisville, Kentucky)
ABSTRACT	A system and method for detecting personal protective equipment (PPE) compliance is disclosed. Personal protective equipment, such as gloves, gowns, masks, protective eyewear, may be used to limit transmission of illness either from the patient to the care giver or vice-versa. Compliance with PPE is important in various contexts, including hospital settings, home settings, work settings, and school settings. For example, a healthcare provider may wear a wristband, which may interact with a stationary controller that is associated with an entrance and/or an exit to an area for the patient (such as the stationary controller integrated with or proximate to a hand cleaning agent dispenser) proximate to the entrance and/or exit. The interaction may be used to determine whether the healthcare provider has complied with PPE protocols. Further, the system may be used to train healthcare providers or others in PPE hygiene. In addition, the wristband may be used to check for compliance of a plurality of protocols, such as PPE protocols and hand hygiene (HH) protocols. In this way, the system may be used for safely interacting with patients in order to reduce cross-contamination.
FILED	Monday, October 01, 2018
APPL NO	16/148683
ART UNIT	2686 — Audio Signals
CURRENT CPC	Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/245 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/20 (20180101) G16H 50/30 (20180101)
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Department of Agriculture (USDA)

10675241 — Compositions containing preen oil and methods of use thereof

US 10675241	Cook et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	Mark E. Cook (Madison, Wisconsin); Jordan Sand (Madison, Wisconsin); Jake M. Olson (Madison, Wisconsin); Terence P. Barry (Middleton, Wisconsin)
ABSTRACT	Described herein are methods of use of purified preen oil, food and feed compositions containing purified preen oil, food and feed additives containing purified preen oil, and pharmaceutical compositions containing purified preen oil. Methods include treatment of chronic joint inflammation in humans and animals by orally administering purified preen oil. Also included are methods of feeding a growing fish by feeding the feeding the growing fish purified preen oil in amounts effective to improve survival and/or stimulate growth in the growing fish. Further included are methods of feeding live prey organisms purified preen oil, and feeding the live prey organisms to growing fish.
FILED	Tuesday, February 27, 2018
APPL NO	15/906272
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Fodder A23K 10/20 (20160501) A23K 20/158 (20160501) A23K 50/80 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0056 (20130101) Original (OR) Class A61K 31/232 (20130101) A61K 35/57 (20130101) A61K 45/06 (20130101) Technologies for Adaptation to Climate Change Y02A 40/818 (20180101)
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10676392 — Transparent conducting films containing single-walled carbon nanotubes dispersed in an azo dye

US 10676392	Gunasekaran et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Sundaram Gunasekaran (Madison, Wisconsin); Ashok Kumar Sundramoorthy (Madison, Wisconsin)
ABSTRACT	Described are carbon nanotube dispersions containing single-walled carbon nanotubes dispersed in a dispersant solution comprising a solvent (water, organic polar protic solvents, and/or organic polar aprotic solvents), and an azo compound. The single-walled carbon nanotubes are not cross-linked with covalent bonds. The dispersions are useful for fabricating transparent conductive thin films on flexible and inflexible substrates. Methods for making the transparent conductive thin films are also described.
FILED	Friday, January 20, 2017
APPL NO	15/411464
ART UNIT	1764 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/007 (20130101) C03C 17/009 (20130101) Original (OR) Class C03C 2217/70 (20130101) C03C 2217/465 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 5/24 (20130101) C09D 7/40 (20180101) C09D 7/61 (20180101) C09D 7/63 (20180101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) H01B 5/14 (20130101) H01B 13/00 (20130101) H01B 13/0036 (20130101)
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10676751 — Production and use of plant degrading materials

US 10676751	Daniell
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) Department of Agriculture (USDA) Agricultural Research Service (ARS) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Henry Daniell (Winter Park, Florida)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Henry Daniell (Winter Park, Florida)
ABSTRACT	Disclosed herein are materials useful for degrading plant biomass material. In exemplary embodiments, the plant material comprises one or more enzymes that are expressed in plants and/or bacteria. Specifically exemplified herein are plant degrading enzymes expressed in chloroplasts. The chloroplast expressed enzymes may be provided as cocktails for use in conjunction with conventional methods of converting biomass into biofuels, such as cellulosic ethanol.
FILED	Monday, March 02, 2009
APPL NO	12/396382
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2437 (20130101) C12N 9/2445 (20130101) C12N 9/2482 (20130101) C12N 15/8214 (20130101) Original (OR) Class C12N 15/8242 (20130101) C12N 15/8257 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/12 (20130101) Enzymes C12Y 302/01004 (20130101) C12Y 302/01008 (20130101) C12Y 302/01021 (20130101) C12Y 302/01091 (20130101)
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10676793 — Dairy cattle breeding for improved milk production traits in cattle

US 10676793	Khatib
FUNDED BY	Department of Agriculture (USDA) Agricultural Research Service (ARS) Cooperative State Research, Education, and Extension Service (CSREES)
APPLICANT(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Hasan Khatib (Madison, Wisconsin)
ABSTRACT	Nucleic acid molecules comprising a SNP site at position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), which SNP indicates a desirable productive life in a dairy cattle. Also disclosed are an array or a kit comprising the same, a method for detecting the SNPs, a method for progeny testing of cattle, and a method for selectively breeding of cattle.
FILED	Thursday, November 07, 2013
APPL NO	14/074685
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/435 (20130101) Peptides C07K 14/47 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 1/6888 (20130101) Original (OR) Class C12Q 2600/124 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/172 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/143333 (20150115)
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Department of Veterans Affairs (DVA)

10674931 — Dielectric sensing for sample characterization

US 10674931	Suster et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS (Washington, District of Columbia)
INVENTOR(S)	Michael Suster (Cleveland, Ohio); Pedram Mohseni (Cleveland, Ohio); Debnath Maji (Cleveland, Ohio); Evi Stavrou (Cleveland, Ohio); Umut Gurkan (Cleveland, Ohio)
ABSTRACT	As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine at least one permittivity parameter based on the computed dielectric permittivity values over at least a portion of the time interval.
FILED	Tuesday, January 17, 2017
APPL NO	16/070126
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/05 (20130101) Original (OR) Class A61B 5/145 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/08 (20130101) G01N 27/026 (20130101) G01N 27/221 (20130101) G01N 33/4905 (20130101)
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10675283 — Compositions and methods for white to beige adipogenesis

US 10675283	Cooper et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	Denise Ratzlaff Cooper (St. Petersburg, Florida); Ryan Adam Kirchoffer (Ocala, Florida); Robert Pleasants Sparks (Urbana, Illinois); Wayne Charles Guida (Saint Pete Beach, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida); The United States Government as Represented by the Department Of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Denise Ratzlaff Cooper (St. Petersburg, Florida); Ryan Adam Kirchoffer (Ocala, Florida); Robert Pleasants Sparks (Urbana, Illinois); Wayne Charles Guida (Saint Pete Beach, Florida)
ABSTRACT	Disclosed herein are compositions and methods for transitioning or converting a white adipocyte to a beige adipocyte. The compositions and methods may be used in the treatment of obesity. In some embodiments, the compositions include a compound selected from DC677 and DC761.
FILED	Monday, March 26, 2018
APPL NO	15/936326
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/473 (20130101) A61K 31/517 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101)
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10676718 — Maintenance and propagation of mesenchymal stem cells

US 10676718	Chen et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)	The Board of Trustees of the University of Arkansas (Little Rock, Arkansas); The United States of America as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Xiao-Dong Chen (San Antonio, Texas); Robert L. Jilka (Little Rock, Arkansas)
ABSTRACT	Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
FILED	Thursday, January 11, 2018
APPL NO	15/868721
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 2035/124 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 25/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0662 (20130101) Original (OR) Class C12N 5/0663 (20130101) C12N 5/0668 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101)
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10677800 — Biomarkers for diagnosis and prognosis of lung cancer

US 10677800	Jiang
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Feng Jiang (Ellicott City, Maryland)
ASSIGNEE(S)	University of Maryland, Baltimore (Baltimore, Maryland); The United States of America as Represented by the Department of Veterans Affairs (Washington, None)
INVENTOR(S)	Feng Jiang (Ellicott City, Maryland)
ABSTRACT	Provided herein are methods for non-invasively diagnosing and/or prognosing a lung cancer and for determining the efficacy of a therapeutic treatment regimen for the lung cancer. Expression levels of at least two small non-coding RNAs, for example, microRNAs and small nucleolar RNAs, are measured and used to calculate an area under the curve (AUC) that provides a probability of lung cancer in the subject. The smoking history of the subject and, if present, the size of pulmonary nodules may be incorporated into the calculation.
FILED	Thursday, September 14, 2017
APPL NO	15/704828
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) Original (OR) Class G01N 2800/7028 (20130101)
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U.S. State Government

10677591 — System and method for measuring three-dimensional surface features

US 10677591	Huang
FUNDED BY	Department of Transportation (USDOT) U.S. State Government State of Texas Texas Department of Transportation (TX-DOT)
APPLICANT(S)	Texas Department of Transportation (Austin, Texas)
ASSIGNEE(S)	Texas Department of Transportation (Austin, Texas)
INVENTOR(S)	Yaxiong Huang (Austin, Texas)
ABSTRACT	In some embodiments, a system for measuring surface features may include a pattern projector, at least one digital imaging device, and an image processing device. The pattern projector may project, during use, a pattern of light on a surface of an object. In some embodiments, the pattern projector moves, during use, the pattern of light along the surface of the object. In some embodiments, the pattern projector moves the pattern of light in response to electronic control signals. At least one of the digital imaging devices may record, during use, at least one image of the projected pattern of light. The image processing device which, during use, converts projected patterns of light recorded on at least one of the images to three-dimensional data points representing a surface geometry of the object using relative positions and relative angles between the at least one imaging device and the pattern projector.
FILED	Thursday, April 19, 2018
APPL NO	15/957374
ART UNIT	2877 — Optics
CURRENT CPC	Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/303 (20130101) Original (OR) Class G01B 11/2527 (20130101) G01B 11/2545 (20130101)
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10680160 — Piezoelectric thin film stack

US 10680160	Abbott, Jr. et al.
FUNDED BY	U.S. State Government State of Oregon
APPLICANT(S)	Hewlett-Packard Development Company, L.P. (Houston, Texas); State of Oregon on behalf of Oregon State Univ. (Corvallis, Oregon)
ASSIGNEE(S)	Oregon State University (Corvallis, Oregon); Hewlett-Packard Development Company, L.P. (Spring, Texas)
INVENTOR(S)	James Elmer Abbott, Jr. (Corvallis, Oregon); Peter Mardilovich (Corvallis, Oregon); Brady Gibbons (Corvallis, Oregon); Bryan Alexander Maack (Corvallis, Oregon)
ABSTRACT	The present disclosure is drawn to a piezoelectric thin film stack and method of preparing the same. The piezoelectric thin film stack can comprise a substrate with an oxide application surface, a metal oxide adhesive blend layer applied to the oxide application surface, and a piezoelectric film applied directly to the metal oxide adhesive blend layer.
FILED	Wednesday, October 30, 2013
APPL NO	15/026311
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Typewriters; Selective Printing Mechanisms,, i.e Mechanisms Printing Otherwise Than From a Forme; Correction of Typographical Errors B41J 2/161 (20130101) B41J 2/1623 (20130101) B41J 2/1626 (20130101) B41J 2/1631 (20130101) B41J 2/1642 (20130101) B41J 2/1645 (20130101) B41J 2/14233 (20130101) B41J 2/14274 (20130101) B41J 2002/14491 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/09 (20130101) H01L 41/27 (20130101) H01L 41/332 (20130101) H01L 41/0477 (20130101) H01L 41/0805 (20130101) Original (OR) Class H01L 41/1876 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Homeland Security (DHS)

10679310 — Intermediate communication service

US 10679310	Maher
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	David Maher (Washington, District of Columbia)
ABSTRACT	Mobile collection and vetting of user supplied information is described. The systems, techniques, devices, methods, and approaches described herein can be used to obtain, validate, and vet information, such as customs information, in a mobile environment. In embodiments, methods comprise receiving information input via a mobile device. The information is encapsulated by an intermediate to escort the information through a firewall to the database. In response to vetting the information to determine if it meets one or more criteria, the method involves creating a record associated with a unique identifier, information that bio-identifies a user, or an indication of a determination that results from the vetting. In this embodiment, the method includes generating an electronic receipt for communication to the mobile device, the electronic receipt including the unique identifier.
FILED	Tuesday, February 26, 2019
APPL NO	16/285636
ART UNIT	3629 — Business Methods - Incentive Programs, Coupons; Operations Research; Electronic Shopping; Health Care; Point of Sale, Inventory, Accounting; Cost/ Price, Reservations, Shipping and Transportation; Business Processing
CURRENT CPC	Electric Digital Data Processing G06F 16/83 (20190101) G06F 16/2228 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Department of Transportation (USDOT)

10677591 — System and method for measuring three-dimensional surface features

US 10677591	Huang
FUNDED BY	Department of Transportation (USDOT) U.S. State Government State of Texas Texas Department of Transportation (TX-DOT)
APPLICANT(S)	Texas Department of Transportation (Austin, Texas)
ASSIGNEE(S)	Texas Department of Transportation (Austin, Texas)
INVENTOR(S)	Yaxiong Huang (Austin, Texas)
ABSTRACT	In some embodiments, a system for measuring surface features may include a pattern projector, at least one digital imaging device, and an image processing device. The pattern projector may project, during use, a pattern of light on a surface of an object. In some embodiments, the pattern projector moves, during use, the pattern of light along the surface of the object. In some embodiments, the pattern projector moves the pattern of light in response to electronic control signals. At least one of the digital imaging devices may record, during use, at least one image of the projected pattern of light. The image processing device which, during use, converts projected patterns of light recorded on at least one of the images to three-dimensional data points representing a surface geometry of the object using relative positions and relative angles between the at least one imaging device and the pattern projector.
FILED	Thursday, April 19, 2018
APPL NO	15/957374
ART UNIT	2877 — Optics
CURRENT CPC	Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/303 (20130101) Original (OR) Class G01B 11/2527 (20130101) G01B 11/2545 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of the Interior (DOI)

10679063 — Recognizing salient video events through learning-based multimodal analysis of visual features and audio-based analytics

US 10679063	Cheng et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of the Interior (DOI)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)	SRI International (Menlo Park, California)
INVENTOR(S)	Hui Cheng (Bridgewater, New Jersey); Ajay Divakaran (Monmouth Junction, New Jersey); Elizabeth Shriberg (Menlo Park, California); Harpreet Singh Sawhney (Princeton, New Jersey); Jingen Liu (Plainsboro, New Jersey); Ishani Chakraborty (Franklin Park, New Jersey); Omar Javed (Franklin Park, New Jersey); David Chisolm (Menlo Park, California); Behjat Siddiquie (Plainsboro, New Jersey); Steven S. Weiner (Merion Station, Pennsylvania)
ABSTRACT	A computing system for recognizing salient events depicted in a video utilizes learning algorithms to detect audio and visual features of the video. The computing system identifies one or more salient events depicted in the video based on the audio and visual features.
FILED	Friday, September 04, 2015
APPL NO	14/846318
ART UNIT	2424 — Cable and Television
CURRENT CPC	Electric Digital Data Processing G06F 16/43 (20190101) G06F 16/78 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00718 (20130101) Original (OR) Class Information Storage Based on Relative Movement Between Record Carrier and Transducer G11B 27/10 (20130101) G11B 27/031 (20130101) Pictorial Communication, e.g Television H04N 21/233 (20130101) H04N 21/4394 (20130101) H04N 21/8549 (20130101) H04N 21/23418 (20130101) H04N 21/44008 (20130101) H04N 21/44029 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

European Union (EU)

10677928 — Method of processing offset carrier modulated ranging signals

US 10677928	Curran et al.
FUNDED BY	European Union (EU)
APPLICANT(S)	THE EUROPEAN UNION, represented by THE EUROPEAN COMMISSION (Brussels, Belgium)
ASSIGNEE(S)	THE EUROPEAN UNION, REPRESENTED BY THE EUROPEAN COMMISSION (Brussels, Belgium)
INVENTOR(S)	James T. Curran (Ballinhassig, Ireland); Matteo Paonni (Gavirate, Italy); Michele Bavaro (Pisa, Italy); Joaquim Fortuny-Guasch (Taino, Italy)
ABSTRACT	A method of processing offset carrier modulated, OCM, ranging signals in a radionavigation system including a plurality of satellite-borne transmitters and at least one ground-based receiver includes receiving a first radionavigation signal from at least one of the plurality of satellite-borne transmitters and down-converting and digitizing the first radionavigation signal to derive therefrom a first OCM signal SA, receiving a second signal SB synchronously broadcast with the first OCM signal SA, the second signal SB having the same or substantially the same center frequency as the first OCM signal SA, coherently combining the first OCM signal SA with the second signal SB at the receiver to generate a combined signal SC, generating a combined correlation value YC corresponding to a correlation of the combined signal SC with a local replica of the first OCM signal SC, and deriving ranging information based on the combined correlation value YC.
FILED	Monday, June 13, 2016
APPL NO	15/737153
ART UNIT	2645 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/02 (20130101) G01S 19/22 (20130101) G01S 19/25 (20130101) G01S 19/30 (20130101) G01S 19/246 (20130101) Original (OR) Class Transmission H04B 1/7085 (20130101) H04B 14/08 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Geospatial Intelligence Agency (NGA)

10677932 — Systems, methods, and devices for geo-localization

US 10677932	Yilmaz et al.
FUNDED BY	National Geospatial Intelligence Agency (NGA)
APPLICANT(S)	Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)	Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S)	Alper Yilmaz (Lewis Center, Ohio); Ashish Gupta (Columbus, Ohio)
ABSTRACT	According to the embodiments provided herein, a trajectory determination device for geo-localization can include one or more relative position sensors, one or more processors, and memory. The one or more processors can execute machine readable instructions to receive the relative position signals from the one or more relative position sensors. The relative position signals can be transformed into a sequence of relative trajectories. Each of the relative trajectories can include a distance and directional information indicative of a change in orientation of the trajectory determination device. A progressive topology can be created based upon the sequence of relative trajectories; this progressive topology can be compared to map data. A geolocation of the trajectory determination device can be determined.
FILED	Tuesday, September 25, 2018
APPL NO	16/141015
ART UNIT	3661 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/30 (20130101) G01C 21/206 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/16 (20130101) G01S 19/26 (20130101) G01S 19/39 (20130101) G01S 19/45 (20130101) G01S 19/51 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10681812 — Method of providing a flexible connector

US 10681812	Hartman
FUNDED BY
APPLICANT(S)	Jeffrey David Hartman (Severn, Maryland)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Jeffrey David Hartman (Severn, Maryland)
ABSTRACT	A flexible connector includes a unitary connector block having first and second board-facing areas. The first and second board-facing areas are longitudinally spaced from each other on a chosen surface of the connector block. The connector block includes a block body transversely separating the chosen surface from an opposing surface oppositely facing from the chosen surface. The connector block includes a flexible connector bridge longitudinally interposed between the first and second board-facing areas. A first connector port is located within the first board-facing area. A second connector port is located within the second board-facing area. A connector trace extends through at least a portion of the block body between the first and second board-facing areas. The connector trace electrically connects the first and second connector ports. Methods of making and using the flexible connector are also included.
FILED	Wednesday, June 12, 2019
APPL NO	16/439415
ART UNIT	2848 — Electrical Circuits and Systems
CURRENT CPC	Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 12/716 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/11 (20130101) H05K 1/148 (20130101) Original (OR) Class H05K 1/0278 (20130101) H05K 3/10 (20130101) H05K 3/366 (20130101) H05K 3/4007 (20130101) H05K 3/4691 (20130101) H05K 2201/04 (20130101) H05K 2201/058 (20130101) H05K 2201/10189 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

What You'll Find On This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, June 09, 2020.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2020/fedinvent-patents-20200609.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

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