FedInvent™ Patents

Patent Details for Tuesday, June 30, 2020

This page was updated on Monday, March 27, 2023 at 06:07 AM GMT

Department of Health and Human Services (HHS)

10694939 — Whole eye optical coherence tomography(OCT) imaging systems and related methods

US 10694939	Kuo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Anthony Kuo (Durham, North Carolina); Joseph Izatt (Durham, North Carolina); Ryan McNabb (Durham, North Carolina)
ABSTRACT	Whole eye optical coherence tomography (OCT) imaging systems and related methods are disclosed. According to an aspect, an OCT imaging system includes a source having an associated source arm path. Further, the OCT imaging system includes a reference arm coupled to the source arm. Further, the OCT imaging system includes a sample arm having an associated sample arm path and coupled to the source arm. The sample arm includes at least one optical component configured to simultaneously scan both an anterior and posterior portion of an eye of a subject.
FILED	Monday, May 01, 2017
APPL NO	15/583992
ART UNIT	2872 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/102 (20130101) Original (OR) Class A61B 3/117 (20130101) A61B 3/152 (20130101) A61B 3/1233 (20130101)
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10694942 — Internet-based cognitive diagnostics using visual paired comparison task

US 10694942	Agichtein et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	EMORY UNIVERSITY (Atlanta, Georgia)
ASSIGNEE(S)	EMORY UNIVERSITY (Atlanta, Georgia)
INVENTOR(S)	Yevgeny E. Agichtein (Atlanta, Georgia); Elizabeth A. Buffalo (Atlanta, Georgia); Dmitry Lagun (Atlanta, Georgia); Cecelia Manzanares (Atlanta, Georgia); Stuart Zola (Atlanta, Georgia)
ABSTRACT	Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for diagnosing dementia such as mild cognitive impairment and Alzheimer's disease.
FILED	Tuesday, March 07, 2017
APPL NO	15/452521
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/113 (20130101) Original (OR) Class A61B 5/165 (20130101) A61B 5/168 (20130101)
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10694961 — Assessment of iron deposition post myocardial infarction as a marker of myocardial hemorrhage

US 10694961	Dharmakumar et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Rohan Dharmakumar (Moorpark, California); Ivan Cokic (Los Angeles, California)
ASSIGNEE(S)	CEDARIS-SINAI MEDICAL CENTER (Los Angeles, California)
INVENTOR(S)	Rohan Dharmakumar (Moorpark, California); Ivan Cokic (Los Angeles, California)
ABSTRACT	The invention is directed to methods for diagnosing reperfusion/non-reperfusion hemorrhage and predicting cardiac arrhythmias and sudden cardiac death in subjects comprising using imaging techniques to detect regional iron oxide deposition. The invention also provides treatment methods for subject at increased risk of sudden cardiac death.
FILED	Wednesday, June 13, 2012
APPL NO	14/125307
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0044 (20130101) A61B 5/055 (20130101) A61B 5/0263 (20130101) Original (OR) Class A61B 5/0472 (20130101) A61B 5/02042 (20130101) A61B 5/02405 (20130101) A61B 5/14542 (20130101) A61B 2576/023 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 49/06 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/362 (20130101) A61N 1/3956 (20130101)
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10694962 — Assessment of iron deposition post myocardial infarction as a marker of myocardial hemorrhage

US 10694962	Dharmakumar et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Cedars-Sinai Medical Center (Los Angeles, California)
ASSIGNEE(S)	CEDARS-SINAI MEDICAL CENTER (Los Angeles, California)
INVENTOR(S)	Rohan Dharmakumar (Moorpark, California); Ivan Cokic (Los Angeles, California)
ABSTRACT	The invention provides various methods of identifying myocardial infarction (MI) patients who have microvascular obstruction (MO), persistent microvascular obstruction (PMO), reperfusion hemorrhage, iron deposition, chronic iron deposition, and/or fat infiltration/accumulation. The invention provides various methods of identifying myocardial infarction (MI) patients who are at risk of prolonged inflammation burden in heart, adverse cardiac remodeling, electrical abnormality, mechanical abnormality, malignant cardiac arrhythmia, ischemic heart failure, and/or sudden cardiac death. The invention also provides various methods of treating these MI patients with chelation drugs, anti-inflammatory drugs, fat-lowering drugs, cooling therapies, or device therapies, or their combinations.
FILED	Wednesday, March 09, 2016
APPL NO	15/064817
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0044 (20130101) A61B 5/0263 (20130101) Original (OR) Class A61B 5/4848 (20130101) A61B 5/7275 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/06 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 30/40 (20180101) G16H 50/30 (20180101) Technologies for Adaptation to Climate Change Y02A 90/26 (20180101)
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10694974 — Method and system for MRI-based targeting, monitoring, and quantification of thermal and mechanical bioeffects in tissue induced by high intensity focused ultrasound

US 10694974	Partanen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Aeronautics and Space Administration (NASA) National Space Biomedical Research Institute (NSBRI)
APPLICANT(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington); KONINKLIJKE PHILIPS N.V. (Eindhoven, Netherlands)
ASSIGNEE(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington); KONINKLIJKE PHILIPS N.V. (Eindhoven, Netherlands)
INVENTOR(S)	Ari Partanen (Andover, Massachusetts); Vera Khokhlova (Seattle, Washington); Navid Farr (Seattle, Washington); Donghoon Lee (Seattle, Washington); Wayne Kreider (Seattle, Washington); Tatiana Khokhlova (Seattle, Washington); Adam Maxwell (Seattle, Washington); Yak-Nam Wang (Seattle, Washington); George Schade (Seattle, Washington); Michael Bailey (Seattle, Washington)
ABSTRACT	Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as “boiling histotripsy” (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.
FILED	Friday, March 27, 2015
APPL NO	15/120812
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/015 (20130101) A61B 5/0042 (20130101) A61B 5/055 (20130101) Original (OR) Class A61B 5/4836 (20130101) A61B 2090/374 (20160201) A61B 2576/026 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/288 (20130101) G01R 33/4804 (20130101) G01R 33/4814 (20130101) G01R 33/5602 (20130101) G01R 33/56341 (20130101)
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10694992 — Device and method for monitoring and assessment of movement disorder symptoms

US 10694992	Giuffrida et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Minority Health and Health Disparities (NIMHD) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Joseph P. Giuffrida (Hinckley, Ohio); Dustin A. Heldman (Shaker Heights, Ohio); Thomas O. Mera (Columbus, Ohio)
ASSIGNEE(S)	Great Lakes NeuroTechnologies Inc. (Cleveland, Ohio)
INVENTOR(S)	Joseph P. Giuffrida (Hinckley, Ohio); Dustin A. Heldman (Shaker Heights, Ohio); Thomas O. Mera (Columbus, Ohio)
ABSTRACT	The present invention is directed to a device and method for monitoring and assessment of movement disorder symptoms. The device and method disclosed herein are particularly amenable to remote monitoring of a subject's movement disorder symptoms. Briefly stated, in certain preferred embodiments of the present invention the movement disorder monitoring device accompanies a subject to a remote location where the device is used to record data relating to the severity of a subject's movement disorder symptoms over a period of time. This data is then subsequently used by physicians or other clinicians in optimizing and assessing treatment options directed at alleviating a subject's movement disorder symptoms. The method and device of the present invention can be used to monitor symptoms of a number of movement disorders including but not limited to dystonia, essential tremor, Huntington's disease, various ataxias, multiple sclerosis, psychogenic tremor, and Parkinson's disease.
FILED	Wednesday, August 22, 2018
APPL NO	16/108746
ART UNIT	3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/0077 (20130101) A61B 5/742 (20130101) A61B 5/1101 (20130101) A61B 5/4082 (20130101) A61B 5/4848 (20130101) Original (OR) Class A61B 5/6826 (20130101) A61B 5/7405 (20130101) A61B 2562/0219 (20130101)
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10695025 — Wearable ultrasonic device for circulating tumor cell detection

US 10695025	Gambhir et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
INVENTOR(S)	Milan S. Gambhir (Portola Valley, California); Adam De La Zerda (Palo Alto, California); Bryan D. Knysh (Saratoga, California)
ABSTRACT	An apparatus for detecting circulating tumor cells is provided. A support system for mounting on a patient is provided. An imaging system is attached to the support system. The imaging system comprises a transmitter and receiver system for generating and transmitting signals into the patient and receiving signals from the patient and a controller. The controller comprises a processor and computer readable media. The computer readable media comprises computer readable code for transmitting signals into the patient, computer readable code for receiving signals from the patent, and computer readable code for providing in vivo circulating tumor cell imaging agent data from the received signals from the patient.
FILED	Monday, November 03, 2014
APPL NO	14/531718
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/085 (20130101) Original (OR) Class A61B 8/481 (20130101) A61B 8/488 (20130101) A61B 8/4227 (20130101) A61B 8/4427 (20130101) A61B 8/5223 (20130101)
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10695036 — Magnetic apparatus and methods of use

US 10695036	Allen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida)
INVENTOR(S)	Kyle Douglas Allen (Gainesville, Florida); Jon Paul Dobson (Gainesville, Florida); Elena Georgina Yarmola (Gainesville, Florida); Zachary Kaufman (Plantation, Florida); David P. Arnold (Gainesville, Florida)
ABSTRACT	Provided herein is a magnetic apparatus for collecting superparamagnetic particles from a subject. The superparamagnetic particles are previously injected into the subject and have ligands bound thereto that are specific for one or more non-cell biomarkers. In one embodiment, the superparamagnetic particles are injected into and retrieved from a cavity such as a joint cavity. These compositions and methods allow for the sequestration and removal of inflammatory mediators, as both a diagnostic of the local immune response and a therapeutic that can reduce inflammation in the local disease environment.
FILED	Monday, August 15, 2016
APPL NO	15/236552
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Diagnosis; Surgery; Identification A61B 10/00 (20130101) A61B 10/02 (20130101) Original (OR) Class A61B 10/0045 (20130101) A61B 17/52 (20130101) A61B 17/3421 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6887 (20130101) G01N 33/54326 (20130101) G01N 2333/78 (20130101) G01N 2800/102 (20130101) G01N 2800/105 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49 (20150115)
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10695127 — Nanoelectroablation control and vaccination

US 10695127	Nuccitelli et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Pulse Biosciences, Inc. (Hayward, California)
ASSIGNEE(S)	PULSE BIOSCIENCES, INC. (Hayward, California)
INVENTOR(S)	Richard Lee Nuccitelli (Millbrae, California); Jon Casey Berridge (Oakland, California); Zachary Mallon (San Francisco, California); Mark Kreis (San Francisco, California); Brian Athos (San Francisco, California); Pamela Nuccitelli (Millbrae, California)
ABSTRACT	Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.
FILED	Monday, April 15, 2019
APPL NO	16/384676
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/04 (20130101) A61B 1/05 (20130101) A61B 1/06 (20130101) A61B 1/00009 (20130101) A61B 1/043 (20130101) A61B 1/00045 (20130101) A61B 6/03 (20130101) A61B 6/12 (20130101) A61B 18/1477 (20130101) A61B 18/1492 (20130101) Original (OR) Class A61B 34/20 (20160201) A61B 90/37 (20160201) A61B 2018/00273 (20130101) A61B 2018/00529 (20130101) A61B 2018/00577 (20130101) A61B 2018/00613 (20130101) A61B 2018/00642 (20130101) A61B 2018/00892 (20130101) A61B 2018/00904 (20130101) A61B 2018/00982 (20130101) A61B 2034/101 (20160201) A61B 2034/107 (20160201) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2037/0007 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/40 (20130101) A61N 1/326 (20130101)
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10695137 — Methods, systems, and devices for surgical access and procedures

US 10695137	Farritor et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Board of Regents of the University of Nebraska (Lincoln, Nebraska)
ASSIGNEE(S)	Board of Regents of the University of Nebraska (Lincoln, Nebraska)
INVENTOR(S)	Shane Farritor (Lincoln, Nebraska); Mark Rentschler (Boulder, Colorado); Amy Lehman (York, Nebraska); Stephen Platt (Urbana, Illinois); Jeff Hawks (Beatrice, Nebraska)
ABSTRACT	The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various actuation system embodiments, including fluid actuation systems, drive train actuation systems, and motorless actuation systems. Additional embodiments include a reversibly lockable tube that can provide access for a medical device to a patient's cavity and further provides a reversible rigidity or stability during operation of the device. Further embodiments include various operational components for medical devices, including medical device arm mechanisms that have both axial and rotational movement while maintaining a relatively compact structure. medical device winch components, medical device biopsy/stapler/clamp mechanisms, and medical device adjustable focus mechanisms.
FILED	Monday, April 30, 2018
APPL NO	15/966606
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/30 (20160201) Original (OR) Class A61B 34/70 (20160201) A61B 34/71 (20160201) A61B 34/72 (20160201) A61B 34/73 (20160201) A61B 2017/00278 (20130101) A61B 2017/00539 (20130101) A61B 2017/00544 (20130101) A61B 2034/302 (20160201) A61B 2034/306 (20160201)
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10695288 — Reactive oxygen species (ROS)-responsive compositions and methods thereof

US 10695288	Duvall et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE)
APPLICANT(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Craig L. Duvall (Nashville, Tennessee); John R. Martin (Nashville, Tennessee); Kristin P. O'Grady (Nashville, Tennessee); Christopher E. Nelson (Nashville, Tennessee)
ABSTRACT	A reactive oxygen species savaging emulsion; the emulsion comprising an injectable pharmaceutically acceptable composition and a polymeric poly(propylene sulfide) microsphere for targeted delivery to a site with elevated reactive oxygen species. In embodiments of the present invention, the microsphere is loaded with a biologically active agent.
FILED	Thursday, November 19, 2015
APPL NO	14/946732
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Original (OR) Class A61K 9/107 (20130101) A61K 9/1641 (20130101) A61K 31/121 (20130101) A61K 31/4468 (20130101)
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10695307 — Autoimmune disorder treatment using RXR agonists

US 10695307	Chandraratna et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH) National Cancer Institute (NCI)
APPLICANT(S)	Io Therapeutics, Inc. (Santa Ana, California); Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S)	Io Therapeutics, Inc. (Houston, Texas); Trustees of Dartmouth College (Hanover, New Hampshire)
INVENTOR(S)	Roshantha A. Chandraratna (San Juan Capistrano, California); Ethan Dmitrovsky (Hanover, New Hampshire); Elizabeth Nowak (West Lebanon, New Hampshire); Randolph Noelle (Plainfield, New Hampshire)
ABSTRACT	The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
FILED	Thursday, May 24, 2018
APPL NO	15/988965
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 31/47 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/201 (20130101) A61K 31/216 (20130101) A61K 31/343 (20130101) A61K 31/353 (20130101) A61K 31/4704 (20130101) Technologies for Adaptation to Climate Change Y02A 50/414 (20180101)
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10695322 — Inhibitors of bacterial growth

US 10695322	Lamichhane et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) NIH Office of the Director (NIHOD)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland); Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
INVENTOR(S)	Gyanu Lamichhane (Towson, Maryland); Craig A. Townsend (Baltimore, Maryland); Evan Lloyd (Bunker Hill, West Virginia); Amit Kaushik (Baltimore, Maryland); Pankaj Kumar (Baltimore, Maryland); Joel Freundlich (Princeton, New Jersey); Shaogang Li (Newark, New Jersey); Sean Ekins (Fuquay Varina, North Carolina); Nicole Parrish (Bunker Hilol, West Virginia)
ABSTRACT	New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among β-lactams as they acylate and inhibit L,D-transpeptidases, which likely results in their superior antimicrobial potency. These new antimicrobial agents can be used alone, or in combination with other classic antimicrobial agents that target D,D transpeptidases, when treating bacterial infections.
FILED	Thursday, January 26, 2017
APPL NO	16/073759
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/43 (20130101) A61K 31/43 (20130101) A61K 31/407 (20130101) Original (OR) Class A61K 31/407 (20130101) A61K 31/427 (20130101) A61K 31/427 (20130101) A61K 31/431 (20130101) A61K 31/431 (20130101) A61K 31/496 (20130101) A61K 31/496 (20130101) A61K 31/546 (20130101) A61K 31/546 (20130101) A61K 31/4196 (20130101) A61K 31/4196 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 477/00 (20130101) C07D 477/20 (20130101) C07D 499/893 (20130101) C07D 499/897 (20130101)
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10695324 — Treatment for wolfram syndrome and other endoplasmic reticulum stress disorders

US 10695324	Urano et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Washington University (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Fumihiko Urano (St. Louis, Missouri); Simin Lu (Shanghai, China PRC)
ABSTRACT	The present invention generally relates to a method of treating or preventing an endoplasmic reticulum stress disorder in subjects, such as a method of treating or preventing Wolfram syndrome.
FILED	Monday, September 30, 2019
APPL NO	16/589130
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/4178 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 38/177 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101)
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10695325 — Compounds and methods for treating an epileptic disorder

US 10695325	Baraban
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Regents Of The University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Scott C. Baraban (Novato, California)
ABSTRACT	Provided, inter alia, are methods for treating an epilepsy disorder using clemizole, a clemizole analog, or pharmaceutical salts thereof.
FILED	Friday, December 07, 2018
APPL NO	16/213896
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/20 (20130101) A61K 31/20 (20130101) A61K 31/27 (20130101) A61K 31/27 (20130101) A61K 31/36 (20130101) A61K 31/55 (20130101) A61K 31/137 (20130101) A61K 31/137 (20130101) A61K 31/195 (20130101) A61K 31/195 (20130101) A61K 31/197 (20130101) A61K 31/197 (20130101) A61K 31/357 (20130101) A61K 31/433 (20130101) A61K 31/433 (20130101) A61K 31/473 (20130101) A61K 31/473 (20130101) A61K 31/551 (20130101) A61K 31/551 (20130101) A61K 31/4015 (20130101) A61K 31/4166 (20130101) A61K 31/4184 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/5513 (20130101) A61K 31/7048 (20130101) A61K 31/7048 (20130101) A61K 33/00 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10695326 — Compositions and methods for treating or preventing dermal disorders

US 10695326	Sell et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	DREXEL UNIVERSITY (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Drexel University (Philadelphia, Pennsylvania)
INVENTOR(S)	Christian Sell (Conshohocken, Pennsylvania); Timothy Nacarelli (Norristown, Pennsylvania); Ashley Azar (North Wales, Pennsylvania)
ABSTRACT	The present invention includes compositions and methods for treating or preventing certain dermal disorders including dermal atrophy, pseudoscars, actinic keratosis, seborrheic or actinic keratoses, lentigines, focal areas of dermal thickening, and coarse wrinkles. In certain embodiments, the compositions useful within the invention comprise a therapeutically effective amount of a mTORC1 inhibitor and a dermatologically acceptable carrier.
FILED	Monday, September 19, 2016
APPL NO	15/762317
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) Original (OR) Class A61K 31/501 (20130101) A61K 31/519 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101)
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10695341 — Compositions and methods for treating endometriosis

US 10695341	Nanjundan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); PONCE HEALTH SCIENCES UNIVERSITY (Ponce, Puerto Rico)
ASSIGNEE(S)	University of South Florida (Tampa, Florida); Ponce Health Sciences University (Ponce, Puerto Rico)
INVENTOR(S)	Meera Nanjundan (Tampa, Florida); Kyle A. Bauckman (St. Louis, Missouri); Idhaliz Flores (Ponce, Puerto Rico)
ABSTRACT	Provided herein are methods of treating and/or preventing endometriosis or symptom thereof, assays for diagnosing/prognosing endometriosis, compositions and formulations for treating and/or preventing endometriosis or symptom thereof, and populations of endometiotic cells, including life-extended populations of cells.
FILED	Wednesday, November 18, 2015
APPL NO	15/527998
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4706 (20130101) Original (OR) Class A61K 31/4709 (20130101) A61K 31/7105 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) C12N 2320/35 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/689 (20130101) G01N 2333/46 (20130101) G01N 2800/364 (20130101)
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10695346 — 4,6-pyrimidinylene derivatives and uses thereof

US 10695346	Gray et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S)	Nathanael S. Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts)
ABSTRACT	The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., lung cancer, breast cancer, leukemia, lymphoma, melanoma, multiple myeloma, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase (e.g. a protein kinase (e.g. a cyclin-dependent kinase (CDK) (e.g. CDK7, CDK12, or CDK13) or a lipid kinase such as a phosphatidylinositol-5-phosphate 4-kinase (PIP4K) (e.g., PI5P4Kα, PI5P4Kβ, or PI5P4Kγ)) in the subject.
FILED	Friday, June 24, 2016
APPL NO	15/737535
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/497 (20130101) A61K 31/497 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Heterocyclic Compounds C07D 401/04 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 407/04 (20130101) C07D 471/04 (20130101)
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10695355 — Methods for pharmacologic treatment of stroke

US 10695355	Liang et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	University of Connecticut (Farmington, Connecticut); The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maine)
ASSIGNEE(S)	UNIVERSITY OF CONNECTICUT (Farmington, Connecticut); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
INVENTOR(S)	Bruce Liang (Avon, Connecticut); Rajkumar Verma (New Haven, Connecticut); Kenneth A. Jacobson (Silver Spring, Maryland)
ABSTRACT	Described herein are methods for the treatment of a human subject who has had a stroke by administering to the subject a pharmaceutical composition including an antagonist of the P2X4 receptor. The antagonist of the P2X4 receptor can be administered in the acute phase of stroke, optionally in combination with a thrombolytic therapeutic or a procedure on the subject involving a clot-removal device.
FILED	Friday, March 23, 2018
APPL NO	15/933536
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/551 (20130101) A61K 31/5513 (20130101) Original (OR) Class A61K 31/5517 (20130101) A61K 47/20 (20130101) A61K 47/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101)
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10695360 — Adiponectin secretion enhancer

US 10695360	Yoshino et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	WASHINGTON UNIVERSITY (Saint Louis, Missouri); Oriental Yeast Co., Ltd. (Tokyo, Japan)
ASSIGNEE(S)	Washington University (Saint Louis, Missouri)
INVENTOR(S)	Jun Yoshino (Creve Coeur, Missouri); Hisataka Yasuda (Shiga, Japan); Hideo Arai (Tokyo, Japan); Tetsuro Enomoto (Tokyo, Japan)
ABSTRACT	The present disclosure provides for the administration of β-NMN, which increases the secretion of adiponectin. The present disclosure also provides an adiponectin secretion enhancer comprising β-nicotinamide mononucleotide, a pharmaceutically acceptable salt thereof or a solvate thereof, and a dietary supplement containing the aforementioned secretion enhancer, which can be ingested in order to increase the secretion of adiponectin. Also disclosed are methods of treating insulin resistance-related diseases such as of metabolic syndrome, diabetes, hyperlipidemia, fatty liver disease, hypertension, obesity, and arteriosclerosis.
FILED	Thursday, February 15, 2018
APPL NO	15/898016
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Fodder A23K 20/153 (20160501) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/13 (20160801) A23L 33/20 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 8/675 (20130101) A61K 9/0056 (20130101) A61K 9/0095 (20130101) A61K 31/122 (20130101) A61K 31/165 (20130101) A61K 31/185 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/205 (20130101) A61K 31/702 (20130101) A61K 31/706 (20130101) Original (OR) Class A61K 31/706 (20130101) A61K 31/7004 (20130101) A61K 31/7012 (20130101) A61K 36/38 (20130101) A61K 36/38 (20130101) A61K 36/77 (20130101) A61K 36/77 (20130101) A61K 36/81 (20130101) A61K 36/81 (20130101) A61K 36/185 (20130101) A61K 36/185 (20130101) A61K 36/9068 (20130101) A61K 38/063 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/10 (20180101)
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10695378 — Direct reprogramming of cells to cardiac myocyte fate

US 10695378	Dzau et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Victor J. Dzau (Durham, North Carolina); Maria Mirotsou (Durham, North Carolina); Tilanthi Jayawardena (Durham, North Carolina)
ABSTRACT	A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
FILED	Monday, June 04, 2018
APPL NO	15/997422
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/33 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 27/3804 (20130101) A61L 27/3839 (20130101) A61L 29/16 (20130101) A61L 31/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2320/31 (20130101) C12N 2501/65 (20130101) C12N 2501/999 (20130101) C12N 2506/1307 (20130101) C12N 2510/00 (20130101)
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10695401 — Use of vimentin in the modulation of acute inflammation and thrombosis

US 10695401	Lam et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Baylor College of Medicine (Houston, Texas)
ASSIGNEE(S)	Baylor College of Medicine (Houston, Texas)
INVENTOR(S)	Fong Wilson Lam (Houston, Texas); Qi Da (Houston, Texas); Miguel A. Cruz (Pearland, Texas)
ABSTRACT	Embodiments of the disclosure include methods and compositions for treating or preventing acute inflammation using soluble vimentin. In specific embodiments, a vimentin derivative comprising the rod domain is utilized for treating or preventing any disease in which a decrease in leukocyte adhesion is therapeutic. In specific embodiments, a fragment of vimentin that comprises part or all of the rod domain is employed.
FILED	Thursday, November 30, 2017
APPL NO	16/465071
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101)
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10695402 — Erythropoietin for gastrointestinal dysfunction

US 10695402	Elfar et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	University of Rochester (Rochester, New York)
ASSIGNEE(S)	UNIVERSITY OF ROCHESTER (Rochester, New York)
INVENTOR(S)	John Elfar (Rochester, New York); Walaa Elfar (Rochester, New York); Mark Noble (Rochester, New York)
ABSTRACT	This invention relates to treating gastrointestinal dysfunction with erythropoietin (EPO) or its analog.
FILED	Friday, March 16, 2018
APPL NO	15/923275
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1816 (20130101) Original (OR) Class A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/14 (20180101)
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10695404 — Treatment of steroid-induced hyperglycemia with fibroblast growth factor (FGF) 1 analogs

US 10695404	Evans et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	Salk Institute for Biological Studies (La Jolla, California)
ASSIGNEE(S)	Salk Institute for Biological Studies (La Jolla, California)
INVENTOR(S)	Ronald M. Evans (La Jolla, California); Michael Downes (San Diego, California); Annette Atkins (San Diego, California); Ruth T. Yu (La Jolla, California)
ABSTRACT	Methods of using FGF1 analogs, such as FGF1 mutant proteins having an N-terminal deletion, point mutation(s), or combinations thereof, to reduce blood glucose levels in subjects with steroid-induced diabetes, hypercortisolemia, or diabetes due to treatment with an antipsychotic agent, are provided. Such mutant FGF1 proteins can be part of a chimeric protein that includes a β-Klotho-binding protein, an FGFR1-binding protein, a β-Klotho-binding protein and a FGFR1-binding protein, a C-terminal region from FGF19 or FGF21.
FILED	Friday, April 13, 2018
APPL NO	15/952516
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) A61K 31/573 (20130101) A61K 31/7088 (20130101) A61K 31/7088 (20130101) A61K 38/1825 (20130101) Original (OR) Class A61K 38/1825 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 14/50 (20130101) C07K 14/501 (20130101) C07K 2319/70 (20130101)
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10695410 — Compositions comprising angiogenic factors and methods of use thereof

US 10695410	Seavey et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Matthew Seavey (Secane, Pennsylvania); Yvonne Paterson (Philadelphia, Pennsylvania); Paulo Maciag (Long Grove, Illinois); Duane Sewell (Cheltenham, Pennsylvania)
ABSTRACT	The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
FILED	Monday, May 28, 2018
APPL NO	15/990790
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/53 (20130101) A61K 2039/57 (20130101) A61K 2039/522 (20130101) A61K 2039/523 (20130101) A61K 2039/585 (20130101) A61K 2039/6037 (20130101) A61K 2039/6068 (20130101) Peptides C07K 14/71 (20130101) C07K 14/195 (20130101) C07K 14/4748 (20130101) C07K 2319/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/74 (20130101)
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10695414 — Modulation of replicative fitness by deoptimization of synonymous codons

US 10695414	Kew et al.
FUNDED BY	Department of Health and Human Services (HHS) Centers for Disease Control and Prevention (CDC) National Center For Infectious Diseases (NCID)
APPLICANT(S)	The Government of the USA as represented by the Secretary of the Dept. of Health and Human Services (Atlanta, Georgia)
ASSIGNEE(S)	The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services, Center for Disease Control and Prevention (Atlanta, Georgia)
INVENTOR(S)	Olen M. Kew (Alpharetta, Georgia); Cara Carthel Burns (Avondale Estates, Georgia); Jing Shaw (Decatur, Georgia); Raymond Campagnoli (Decatur, Georgia); Jacqueline Quay (Chapel Hill, North Carolina)
ABSTRACT	Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
FILED	Thursday, May 31, 2018
APPL NO	15/994074
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/0258 (20130101) Original (OR) Class A61K 2039/522 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/245 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/67 (20130101) C12N 2710/16162 (20130101) C12N 2710/16662 (20130101) C12N 2710/16762 (20130101) C12N 2760/16162 (20130101) C12N 2760/18462 (20130101) C12N 2760/18562 (20130101) C12N 2770/20062 (20130101) C12N 2770/24162 (20130101) C12N 2770/32162 (20130101) C12N 2770/32762 (20130101) C12N 2770/36262 (20130101) Technologies for Adaptation to Climate Change Y02A 50/466 (20180101) Y02A 50/472 (20180101) Y02A 50/476 (20180101)
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10695415 — Live attenuated oral vaccine against shigellosis and typhoid fever

US 10695415	Wu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Protein Potential, LLC (Rockville, Maryland)
ASSIGNEE(S)	Protein Potential, LLC (Rockville, Maryland)
INVENTOR(S)	Yun Wu (Rockville, Maryland); Dennis J. Kopecko (Silver Spring, Maryland); B. Kim Lee Sim (Gaithersburg, Maryland); Stephen L. Hoffman (Gaithersburg, Maryland)
ABSTRACT	Disclosed is the attenuated Salmonella typhi vaccine Ty21a utilized as a vector for Shigella and/or enterotoxogenic E. coli genes stably integrated in the Ty21a chromosome. These genes include a heterologous Shigella sonnei O-antigen biosynthetic gene region that comprises the wzz gene and expresses Shigella sonnei form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system.
FILED	Wednesday, July 06, 2016
APPL NO	15/742459
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/116 (20130101) A61K 39/0275 (20130101) A61K 39/0283 (20130101) Original (OR) Class A61K 2039/70 (20130101) A61K 2039/522 (20130101) A61K 2039/523 (20130101) A61K 2039/543 (20130101) Technologies for Adaptation to Climate Change Y02A 50/476 (20180101) Y02A 50/484 (20180101)
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10695427 — Shape memory particles for biomedical uses

US 10695427	Guo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Qiongyu Guo (College Park, Maryland); Jordan J. Green (Nottingham, Maryland); Randall A. Meyer (Baltimore, Maryland); Corey J. Bishop (Arlington, Massachusetts); Anand Kumar (Baltimore, Maryland); Gregg L. Semenza (Reisterstown, Maryland)
ABSTRACT	The presently disclosed subject matter provides compositions, methods, and kits comprising shape memory particles that can be used for delivering a drug and/or treating a disease or disorder in a patient. Specifically, shape changes in the presently disclosed shape memory particles can be used to control drug delivery spatially and/or temporally in a patient. Also provided are compositions, methods, and kits comprising nanoparticles and hypoxia-inducible factor (HIF) inhibitors with or without chemotherapeutic agents for inhibiting HIF activity in a patient and/or treating a hypoxia-associated disease or disorder.
FILED	Wednesday, April 06, 2016
APPL NO	15/564461
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1647 (20130101) A61K 31/473 (20130101) A61K 31/7048 (20130101) A61K 41/0028 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/6925 (20170801) A61K 47/6937 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 16/00 (20130101)
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10695441 — Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor

US 10695441	Wilson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	James M. Wilson (Philadelphia, Pennsylvania); Guangping Gao (Westborough, Massachusetts); Mauricio R. Alvira (Philadelphia, Pennsylvania); Luc H. Vandenberghe (Weston, Massachusetts)
ABSTRACT	Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
FILED	Tuesday, October 02, 2018
APPL NO	16/149218
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Original (OR) Class Peptides C07K 14/005 (20130101) C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/644 (20130101) C12N 15/86 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) C12N 2750/14143 (20130101) C12N 2750/14151 (20130101) C12N 2830/008 (20130101) C12N 2830/48 (20130101) C12N 2830/85 (20130101) Enzymes C12Y 304/21022 (20130101)
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10695442 — Engineering synthetic brain penetrating gene vectors

US 10695442	Hanes et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Justin Hanes (Baltimore, Maryland); Jung Soo Suk (Baltimore, Maryland); Panagiotis Mastorakos (Charlottesville, Virginia); Graeme Woodworth (Baltimore, Maryland); Clark Zhang (Sunnyvale, California)
ABSTRACT	A synthetic gene delivery platform with a dense surface coating of hydrophilic and neutrally charged PEG, capable of rapid diffusion and widespread distribution in brain tissue, and highly effective gene delivery to target cells therein has been developed. Nanoparticles including nucleic acids, are formed of a blend of biocompatible hydrophilic cationic polymers and they hydrophilic cationic polymer conjugated to hydrophilic neutrally charged polymers such as polyethylene glycol. The nanoparticles are coated with polyethylene glycol at a density that imparts a near neutral charge and optimizes rapid diffusion through the brain parenchyma. Methods of treating a disease or disorder of the brain including administering a therapeutically effective amount of nanoparticles densely coated with polyethylene glycol are also provided.
FILED	Wednesday, March 07, 2018
APPL NO	15/914796
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 9/0085 (20130101) A61K 9/5146 (20130101) A61K 9/5169 (20130101) A61K 9/5192 (20130101) A61K 47/60 (20170801) A61K 47/6935 (20170801) A61K 48/0008 (20130101) Original (OR) Class A61K 48/0075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101)
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10695444 — Alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof

US 10695444	Anderson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Daniel Griffith Anderson (Framingham, Massachusetts); Joseph R. Dorkin (Somerville, Massachusetts); Owen Shea Fenton (Somerville, Massachusetts); Kevin John Kauffman (Somerville, Massachusetts); Rebecca L. McClellan (Westwood, Massachusetts)
ABSTRACT	Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of R^Lis independently optionally substituted C₆-C₄₀alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
FILED	Wednesday, February 06, 2019
APPL NO	16/268902
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1816 (20130101) A61K 47/545 (20170801) A61K 48/0033 (20130101) Original (OR) Class Heterocyclic Compounds C07D 241/08 (20130101)
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10695446 — Composition and method for detecting hypoxia

US 10695446	Uddin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Imam Uddin (Nashville, Tennessee); Ashwath Jayagopal (Nashville, Tennessee); Jashim Uddin (Nashville, Tennessee); John S. Penn (Brentwood, Tennessee); Lawrence J. Marnett (Nashville, Tennessee)
ABSTRACT	A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.
FILED	Monday, May 02, 2016
APPL NO	15/567355
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/05 (20130101) A61K 31/19 (20130101) A61K 31/19 (20130101) A61K 31/045 (20130101) A61K 31/045 (20130101) A61K 31/58 (20130101) A61K 31/454 (20130101) A61K 31/517 (20130101) A61K 31/4178 (20130101) A61K 31/4375 (20130101) A61K 31/4545 (20130101) A61K 45/06 (20130101) A61K 49/0017 (20130101) A61K 49/0021 (20130101) A61K 49/0023 (20130101) A61K 49/0032 (20130101) A61K 49/0041 (20130101) A61K 49/0052 (20130101) Original (OR) Class A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 43/00 (20180101) Heterocyclic Compounds C07D 403/14 (20130101) C07D 405/14 (20130101) C07D 487/22 (20130101) C07D 493/16 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 62/78 (20130101) C09B 62/3435 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1018 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101) G01N 33/52 (20130101) G01N 2800/7038 (20130101)
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10695480 — Gas exchange composite membranes and methods of use thereof

US 10695480	Roy et al.
FUNDED BY	Department of Health and Human Services (HHS) Food and Drug Administration (FDA) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Shuvo Roy (San Ramon, California); Torin Yeager (San Francisco, California); Emily Abada (San Francisco, California); Ajay S. Dharia (San Bruno, California)
ABSTRACT	Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.
FILED	Wednesday, November 18, 2015
APPL NO	15/527590
ART UNIT	3781 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/267 (20140204) A61M 1/1698 (20130101) Original (OR) Class A61M 2202/0478 (20130101) A61M 2209/088 (20130101) Separation B01D 53/228 (20130101) B01D 69/02 (20130101) B01D 69/12 (20130101) B01D 71/70 (20130101) B01D 2257/104 (20130101) B01D 2325/02 (20130101) B01D 2325/04 (20130101) B01D 2325/20 (20130101)
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10695483 — Self-sealing cannula

US 10695483	Wu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland)
ASSIGNEE(S)	University of Maryland, Baltimore (Baltimore, Maryland)
INVENTOR(S)	Zhongjun Wu (Marriottsville, Maryland); Bartley P. Griffith (Gibson Island, Maryland); Keshava Rajagopal (Sugar Land, Texas)
ABSTRACT	The present invention discloses a self-sealing cannula that through a self-sealing mechanism fixed on the ventricular wall or atrial wall, the cannula body is attached to the self-sealing fixture and blood is drawn into the lumen via an external pump and returned to the circulation system through a separate cannula; in the case of the double lumen cannula embodiment, the blood will be drawn into the drainage lumen of the double lumen cannula and returned through an infusion lumen at the desired location.
FILED	Wednesday, November 11, 2015
APPL NO	15/526107
ART UNIT	3781 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/3417 (20130101) A61B 17/3421 (20130101) A61B 17/3439 (20130101) A61B 2017/00247 (20130101) A61B 2017/3419 (20130101) A61B 2017/3425 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/101 (20130101) A61M 1/122 (20140204) A61M 1/1008 (20140204) A61M 1/3659 (20140204) Original (OR) Class
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10695523 — Systems and methods for generating nitric oxide

US 10695523	Zapol et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Third Pole, Inc. (Arlington, Massachusetts)
ASSIGNEE(S)	Third Pole, Inc. (Waltham, Massachusetts)
INVENTOR(S)	David G. Zapol (San Francisco, California); Gregory W. Hall (Belmont, Massachusetts); Wolfgang Scholz (Beverly, Massachusetts); Ian J. Gillerman (Somerville, Massachusetts)
ABSTRACT	Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO₂gas analysis sensors without the use of a calibration gas.
FILED	Wednesday, November 27, 2019
APPL NO	16/697498
ART UNIT	3785 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 33/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/04 (20130101) A61M 16/12 (20130101) Original (OR) Class A61M 16/022 (20170801) A61M 16/024 (20170801) A61M 16/0057 (20130101) A61M 16/0093 (20140204) A61M 16/101 (20140204) A61M 16/107 (20140204) A61M 16/202 (20140204) A61M 16/0666 (20130101) A61M 2202/0007 (20130101) A61M 2202/0057 (20130101) A61M 2202/0275 (20130101) A61M 2202/0275 (20130101) A61M 2202/0283 (20130101) A61M 2202/0283 (20130101) A61M 2205/05 (20130101) A61M 2205/054 (20130101) A61M 2205/80 (20130101) A61M 2205/125 (20130101) A61M 2205/502 (20130101) A61M 2205/3584 (20130101) A61M 2205/8206 (20130101) A61M 2209/088 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/32 (20130101)
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10695540 — Segmented metallic guidewires

US 10695540	Kocaturk et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Ozgur Kocaturk (Rockville, Maryland); Burcu Basar (Washington, District of Columbia); Robert J. Lederman (Chevy Chase, Maryland)
ABSTRACT	Disclosed herein are embodiments of segmented metallic guidewires that are suitable for MRI catheterization. Disclosed guidewires comprise a plurality of short conductive metallic segments that individually are short enough such that they do not resonate during MRI. The conductive segments are electrically insulated from each other and mechanically coupled together end-to-end via connectors, such as stiffness matched connectors, to provide a sufficiently long, strong, and flexible guidewire for catheterization that is non-resonant during MRI.
FILED	Monday, October 19, 2015
APPL NO	15/514744
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/09 (20130101) Original (OR) Class A61M 2025/09075 (20130101) A61M 2025/09108 (20130101) A61M 2025/09133 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/286 (20130101) G01R 33/288 (20130101) G01R 33/3685 (20130101)
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10695586 — System for emission-guided high-energy photon delivery

US 10695586	Harper et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	RefleXion Medical, Inc. (Hayward, California)
ASSIGNEE(S)	RefleXion Medical, Inc. (Hayward, California)
INVENTOR(S)	Brent Harper (Pescadero, California); Robert Wiggers (Belmont, California); David Larkin (Menlo Park, California); David Meer (Novelty, Ohio); David Nett (Danville, California); Rostem Bassalow (Hayward, California); Peter Olcott (Los Gatos, California); Chris Julian (Los Gatos, California); Brent Dolan (Hayward, California); William Jorge Pearce (Orinda, California)
ABSTRACT	Disclosed herein are radiation therapy systems and methods. These radiation therapy systems and methods are used for emission-guided radiation therapy, where gamma rays from markers or tracers that are localized to patient tumor regions are detected and used to direct radiation to the tumor. The radiation therapy systems described herein comprise a gantry comprising a rotatable ring coupled to a stationary frame via a rotating mechanism such that the rotatable ring rotates up to about 70 RPM, a radiation source (e.g., MV X-ray source) mounted on the rotatable ring, and one or more PET detectors mounted on the rotatable ring.
FILED	Wednesday, November 15, 2017
APPL NO	15/814222
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1045 (20130101) A61N 5/1049 (20130101) A61N 5/1081 (20130101) Original (OR) Class A61N 2005/005 (20130101) A61N 2005/1052 (20130101) A61N 2005/1091 (20130101) A61N 2005/1094 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/046 (20130101)
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10696624 — Cannabinoid receptor CB2 ligand 4-(aminomethyl)-N,N-dialkylanilines

US 10696624	Xie et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Xiang-Qun Xie (Sewickley, Pennsylvania); Abdulrahman Almehizia (Pittsburgh, Pennsylvania); Peng Yang (Pittsburgh, Pennsylvania)
ABSTRACT	Disclosed herein are novel cannabionid receptor-2 (CB2) agonists and inverse agonists represented by Formula (I), and method of modulating the activity of CB2 by contacting the CB-2 receptor with a compound of Formula (I). Also, disclosed are methods for treating multiple myeloma or osteoporosis in a mammal in need thereof by modulating the activity of a cannabinoid receptor-2 (CB2).
FILED	Friday, June 17, 2016
APPL NO	15/580539
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/10 (20180101) A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 311/13 (20130101) C07C 311/18 (20130101) C07C 311/29 (20130101) Original (OR) Class Heterocyclic Compounds C07D 213/42 (20130101) C07D 241/44 (20130101) C07D 317/58 (20130101) C07D 333/34 (20130101) C07D 333/38 (20130101) C07D 401/12 (20130101) C07D 405/12 (20130101) C07D 409/12 (20130101)
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10696631 — Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents

US 10696631	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
INVENTOR(S)	Xiaoyuan Chen (Potomac, Maryland); Orit Jacobson Weiss (Silver Spring, Maryland)
ABSTRACT	The present invention is directed to a compound of Formula I or Formula III or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt: wherein the definitions R₁-R₁₃and L₁-L₄are provided in the disclosure, and wherein R14 is a peptide. The compounds of Formula I may be covalently bonded to a peptide via a linker to provide a compound of Formula III and thereby extend the half-life of the therapeutic compound. The invention is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use in the diagnosis or treatment of diseases.
FILED	Tuesday, May 09, 2017
APPL NO	16/099488
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 51/082 (20130101) A61K 51/088 (20130101) A61K 51/0497 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) C07B 2200/05 (20130101) Heterocyclic Compounds C07D 207/444 (20130101) C07D 207/452 (20130101) Original (OR) Class
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10696635 — Versatile ligand for palladium-catalyzed meta-C—H functionalizations of aromatic substrates

US 10696635	Yu
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S)	Jin-Quan Yu (San Diego, California)
ABSTRACT	A class of mono-protected 3-amino-2-hydroxypyridine (MPAHP) ligands that enable the meta-C—H arylation of anilines, phenols, phenylacetic acids, and biologically relevant heterocyclic compounds using norbornene as a transient mediator is disclosed, such as in the formation of a reaction product of Formula IA: The applicability of this meta-arylation methodology in the pharmaceutical industry is illustrated for heteroaryl substrates and heteroaryl iodide coupling partners, a feat made possible by using the MPAHP ligand. The enabling nature of MPAHP ligands to achieve other meta-C—H functionalization processes is also illustrated by the development of a meta-C—H amination reaction and a meta-C—H alkynylation reaction.
FILED	Tuesday, April 18, 2017
APPL NO	16/094707
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/44 (20130101) Heterocyclic Compounds C07D 213/26 (20130101) C07D 213/30 (20130101) C07D 213/36 (20130101) C07D 213/40 (20130101) C07D 213/55 (20130101) C07D 213/68 (20130101) Original (OR) Class C07D 213/72 (20130101) C07D 215/38 (20130101) C07D 217/12 (20130101) C07D 217/18 (20130101) C07D 217/24 (20130101) C07D 231/12 (20130101) C07D 231/56 (20130101) C07D 239/26 (20130101) C07D 239/42 (20130101) C07D 241/12 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 409/12 (20130101) C07D 409/14 (20130101) C07D 413/12 (20130101)
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10696642 — TEAD transcription factor autopalmitoylation inhibitors

US 10696642	Wu
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Xu Wu (Lexington, Massachusetts)
ABSTRACT	The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcription factor including, e.g., cancer and other diseases.
FILED	Friday, September 23, 2016
APPL NO	15/762993
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 213/82 (20130101) C07D 249/12 (20130101) Original (OR) Class C07D 249/14 (20130101) C07D 271/113 (20130101) C07D 277/74 (20130101) C07D 285/125 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/25 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/5091 (20130101)
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10696673 — Bicyclic inhibitors of histone deacetylase

US 10696673	Fuller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Rodin Therapeutics, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	Rodin Therapeutics, Inc. (Waltham, Massachusetts)
INVENTOR(S)	Nathan Oliver Fuller (Arlington, Massachusetts); John A. Lowe, III (Stonington, Connecticut)
ABSTRACT	Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
FILED	Tuesday, November 12, 2019
APPL NO	16/681213
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101)
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10696682 — CDK inhibitors

US 10696682	Tavares et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	G1 Therapeutics, Inc. (Research Triangle Park, North Carolina)
ASSIGNEE(S)	G1 Therapeutics, Inc. (Research Triangle Park, North Carolina)
INVENTOR(S)	Francis X. Tavares (Durham, North Carolina); Jay Copeland Strum (Hillsborough, Connecticut)
ABSTRACT	Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
FILED	Wednesday, December 19, 2018
APPL NO	16/226430
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/499 (20130101) Heterocyclic Compounds C07D 487/14 (20130101) Original (OR) Class C07D 487/20 (20130101) C07D 498/14 (20130101) C07D 519/00 (20130101)
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10696689 — Somatostatin modulators and uses thereof

US 10696689	Han et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	CRINETICS PHARMACEUTICALS, INC. (San Diego, California)
ASSIGNEE(S)	CRINETICS PHARMACEUTICALS, INC. (San Diego, California)
INVENTOR(S)	Sangdon Han (San Diego, California); Sun Hee Kim (San Diego, California); Yunfei Zhu (San Diego, California)
ABSTRACT	Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.
FILED	Tuesday, September 17, 2019
APPL NO	16/572921
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/08 (20130101) A61K 9/2013 (20130101) A61K 9/2054 (20130101) A61K 9/4825 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 498/04 (20130101) Original (OR) Class
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10696695 — BODIPY dyes for biological imaging

US 10696695	Mazitschek et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Ralph Mazitschek (Belmont, Massachusetts); Alexandra M. Courtis (Davis, California); James Adam Hendricks (Watertown, Massachusetts)
ABSTRACT	This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: is a BODIPY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent.
FILED	Monday, June 25, 2018
APPL NO	16/017638
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 51/0446 (20130101) Heterocyclic Compounds C07D 257/08 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101) Original (OR) Class C07F 5/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/534 (20130101)
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10696710 — Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway

US 10696710	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Zhijian Chen (Dallas, Texas); Lijun Sun (Dallas, Texas); Jiaxi Wu (Dallas, Texas); Heping Shi (Dallas, Texas); Chuo Chen (Dallas, Texas)
ABSTRACT	Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
FILED	Friday, December 13, 2019
APPL NO	16/714595
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7084 (20130101) A61K 39/39 (20130101) A61K 2039/55511 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/25 (20130101) C12Q 1/6876 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 33/573 (20130101) G01N 2333/9015 (20130101) G01N 2333/9125 (20130101) G01N 2400/00 (20130101) G01N 2500/02 (20130101)
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10696719 — Nucleoside triphosphate transporter and uses thereof

US 10696719	Romesberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
ASSIGNEE(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S)	Floyd E. Romesberg (La Jolla, California); Yorke Zhang (San Diego, California)
ABSTRACT	Disclosed herein are proteins, methods, cells, engineered microorganisms, and kits for generating a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum. Also disclosed herein proteins, methods, cells, engineered microorganisms, and kits for production of a nucleic acid molecule that comprises an unnatural nucleotide utilizing a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum.
FILED	Tuesday, August 20, 2019
APPL NO	16/546097
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/405 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/10 (20130101) C12N 15/11 (20130101) C12N 15/90 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101)
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10696720 — Nucleoside triphosphate transporter and uses thereof

US 10696720	Romesberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
ASSIGNEE(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S)	Floyd E. Romesberg (La Jolla, California); Yorke Zhang (San Diego, California)
ABSTRACT	Disclosed herein are proteins, methods, cells, engineered microorganisms, and kits for generating a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum. Also disclosed herein proteins, methods, cells, engineered microorganisms, and kits for production of a nucleic acid molecule that comprises an unnatural nucleotide utilizing a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum.
FILED	Tuesday, August 20, 2019
APPL NO	16/546100
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/405 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/10 (20130101) C12N 15/11 (20130101) C12N 15/90 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101)
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10696727 — Targeted delivery of glycine receptors to excitable cells

US 10696727	Cascio et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Michael Cascio (Pittsburgh, Pennsylvania); Joseph C. Glorioso, III (Blawnox, Pennsylvania); James R. Goss (Bethel Park, Pennsylvania); David Krisky (Sewickley, Pennsylvania)
ABSTRACT	The invention provides a method of modulating electrophysiological activity of an excitable cell. The method involves causing exogenous expression of a glycine receptor (GlyR) protein in an excitable cell of a subject. Thereafter, the excitable cell is exposed to an allosteric modulator of the GlyR protein. Modulation of the exogenous GlyR protein (an ion channel) in response to the allosteric modulator modulates the electrophy-stological activity of the excitable cell. The method can be used to control pain in a subject. The invention further provides a replication-defective HSV vector comprising an expression cassette encoding a GlyR protein, stocks and pharmaceutical compositions containing such vectors, and a transgenic animal.
FILED	Monday, December 29, 2014
APPL NO	14/584895
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2217/20 (20130101) A01K 2217/206 (20130101) A01K 2227/105 (20130101) A01K 2267/0356 (20130101) A01K 2267/0393 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 48/005 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2710/16643 (20130101) C12N 2800/30 (20130101)
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10696769 — pH-sensitive polymeric compositions, kits, and methods

US 10696769	Ekchian et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Gregory James Ekchian (Belmont, Massachusetts); Michael John Cima (Winchester, Massachusetts)
ABSTRACT	Provided herein are polymeric compositions having a relaxation time that is a function of pH. The polymeric compositions can include an anionic monomer, a cationic monomer, and a crosslinker. The crosslinker may comprise at least one of a diacrylate crosslinker and a dimethacrylate crosslinker. Also provided herein are methods of pH sensing, and methods of forming a polymeric composition. Kits of parts also are provided that include a polymeric composition. The polymeric compositions may be used to determine the pH of one or more biological tissues and/or liquids.
FILED	Thursday, December 01, 2016
APPL NO	15/366740
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/1468 (20130101) A61B 5/4848 (20130101) A61B 5/14507 (20130101) A61B 5/14539 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/06 (20130101) C08F 220/06 (20130101) C08F 220/06 (20130101) C08F 220/34 (20130101) Original (OR) Class C08F 220/34 (20130101) C08F 220/34 (20130101) C08F 222/102 (20200201) C08F 222/102 (20200201) C08F 2800/20 (20130101) Compositions of Macromolecular Compounds C08L 33/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/84 (20130101)
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10696944 — Intracellular delivery

US 10696944	Sharei et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Armon R. Sharei (Watertown, Massachusetts); Andrea Adamo (Cambridge, Massachusetts); Robert S. Langer (Newton, Massachusetts); Klavs F. Jensen (Lexington, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Armon R. Sharei (Watertown, Massachusetts); Andrea Adamo (Cambridge, Massachusetts); Robert S. Langer (Newton, Massachusetts); Klavs F. Jensen (Lexington, Massachusetts)
ABSTRACT	A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
FILED	Wednesday, October 17, 2012
APPL NO	14/352354
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) C12M 35/02 (20130101) C12M 35/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101) Original (OR) Class C12N 15/87 (20130101)
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10696946 — T-REG cell expansion

US 10696946	Prabhakar
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Bellur Prabhakar (Oak Brook, Illinois)
ABSTRACT	This invention relates to methods of expanding T regulatory cells through OX40L and Jagged-1 induced signaling. The methods can be used for treating autoimmune diseases.
FILED	Friday, November 03, 2017
APPL NO	15/803232
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/17 (20130101) A61K 35/28 (20130101) A61K 35/28 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) Original (OR) Class C12N 2501/22 (20130101) C12N 2501/415 (20130101) C12N 2501/998 (20130101) C12N 2501/999 (20130101) C12N 2502/08 (20130101) C12N 2502/1121 (20130101)
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10696962 — Nanopipette device and method for subcellular analysis

US 10696962	Actis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Paolo Actis (London, United Kingdom); Michelle M. Maalouf (Concord, California); Nader Pourmand (Santa Cruz, California)
ABSTRACT	Described herein are devices and methods for extracting cellular material from living cells and then depositing them into to a receptacle in a nanoliter scale. Using a nanopipette integrated into a scanning ion conductance microscope (SICM), extraction of mitochondrial DNA from human BJ fibroblasts and Green Fluorescent Protein (GFP) transcripts from HeLa/GFP cells was achieved with minimal disruption to the cellular milieu and without chemical treatment prior to obtaining the isolated sample. Success of the extraction was confirmed by fluorescence microscopy and PCR analysis of the extracted material. The method and apparatus may be applied to many different cell types and intracellular targets, allowing not only single cell analysis, but single subcellular compartment analysis of materials extracted in their native state.
FILED	Thursday, March 13, 2014
APPL NO	14/775168
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 47/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) C12Q 1/6876 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 2035/1034 (20130101) G01N 2333/91 (20130101) G01N 2440/14 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/44 (20130101)
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10696969 — Targeted augmentation of nuclear gene output

US 10696969	Krainer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Cold Spring Harbor Laboratory (Cold Spring Harbor, New York)
ASSIGNEE(S)	Cold Spring Harbor Laboratory (Cold Spring Harbor, New York)
INVENTOR(S)	Adrian Krainer (Huntington Station, New York); Isabel Aznarez (Queens, New York)
ABSTRACT	Provided herein are methods and compositions for increasing production of a target protein or functional RNA by a cell.
FILED	Tuesday, April 10, 2018
APPL NO	15/949902
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 14/47 (20130101) C07K 14/805 (20130101) C07K 14/4702 (20130101) C07K 14/4736 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/3341 (20130101) C12N 2310/3521 (20130101) C12N 2320/11 (20130101) C12N 2320/33 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) Enzymes C12Y 101/01205 (20130101) C12Y 304/24087 (20130101)
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10696972 — Method for improving learning

US 10696972	Zakharenko et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S)	St. Jude Children's Research Hospital, Inc. (Memphis, Tennessee)
ASSIGNEE(S)	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (Memphis, Tennessee)
INVENTOR(S)	Stanislav S. Zakharenko (Collierville, Tennessee); Jay A. Blundon (Memphis, Tennessee)
ABSTRACT	The invention is directed to a method for improving learning and/or memory (e.g., auditory, visual, somatosensory or motor) in adults and children of an age which is beyond the early critical period for learning, said method comprising inhibiting (i) ecto-5′-nucleotidase (Nt5e, aka CD73) or (ii) A1 adenosine receptor (A1R, aka Adora1) expression or function in the brain. The invention is also directed to a method for treating learning and memory defects and neurological diseases associated with an abnormal auditory, visual, or somatosensory perception by inhibiting Nt5e or A1R expression or function in the brain.
FILED	Thursday, February 18, 2016
APPL NO	15/551659
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/416 (20130101) A61K 31/713 (20130101) A61K 31/4545 (20130101) A61K 31/7072 (20130101) A61K 31/7105 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/00 (20130101) G09B 19/00 (20130101)
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10696984 — Packaging cell for making a pseudotyped lentivirus

US 10696984	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Pin Wang (Arcadia, California); Lili Yang (Arcadia, California); David Baltimore (Pasadena, California)
ABSTRACT	Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
FILED	Tuesday, March 05, 2019
APPL NO	16/293151
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/70 (20130101) A61K 35/76 (20130101) A61K 38/20 (20130101) A61K 38/20 (20130101) A61K 38/177 (20130101) A61K 38/177 (20130101) A61K 38/178 (20130101) A61K 38/178 (20130101) A61K 38/191 (20130101) A61K 38/191 (20130101) A61K 38/193 (20130101) A61K 38/193 (20130101) A61K 38/204 (20130101) A61K 38/1774 (20130101) A61K 38/1793 (20130101) A61K 38/2013 (20130101) A61K 38/2026 (20130101) A61K 38/2046 (20130101) A61K 38/2086 (20130101) A61K 39/21 (20130101) A61K 2039/5256 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2740/13043 (20130101) C12N 2740/13045 (20130101) C12N 2740/15041 (20130101) C12N 2740/15043 (20130101) C12N 2740/15045 (20130101) C12N 2770/36122 (20130101) C12N 2770/36134 (20130101) C12N 2810/609 (20130101) C12N 2810/855 (20130101) Technologies for Adaptation to Climate Change Y02A 50/41 (20180101) Y02A 50/48 (20180101) Y02A 50/386 (20180101) Y02A 50/396 (20180101) Y02A 50/401 (20180101) Y02A 50/403 (20180101) Y02A 50/407 (20180101) Y02A 50/412 (20180101) Y02A 50/423 (20180101) Y02A 50/466 (20180101) Y02A 50/475 (20180101) Y02A 50/481 (20180101) Y02A 50/489 (20180101) Y02A 50/492 (20180101)
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10696986 — Protected guide RNAS (PGRNAS)

US 10696986	Zhang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	THE BOARD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S)	Feng Zhang (Cambridge, Massachusetts); Omar O. Abudayyeh (Boston, Massachusetts); James E. Dahlman (Cambridge, Massachusetts); Patrick Hsu (San Diego, California); David A. Scott (Cambridge, Massachusetts)
ABSTRACT	The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems, wherein the guide sequence is modified by secondary structure to increase the specificity of the CRISPR-Cas system and whereby the secondary structure can protect against exonuclease activity and allow for 5′ additions to the guide sequence.
FILED	Monday, June 12, 2017
APPL NO	15/620098
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2217/07 (20130101) A01K 2227/105 (20130101) Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) Enzymes C12Y 301/21004 (20130101)
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10697007 — PCR-activated sorting (PAS)

US 10697007	Abate et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Adam R. Abate (San Francisco, California); Dennis Jay Eastburn (Burlingame, California); Adam R. Sciambi (San Francisco, California); Shaun Lim (Berkeley, California)
ABSTRACT	The methods described herein, referred to as PCR-Activated Sorting (PAS), allow nucleic acids contained in biological systems to be sorted based on their sequence as detected with nucleic acid amplification techniques, e.g., PCR. The nucleic acids can be free floating or contained within living or nonliving structures, including particles, viruses, and cells. The nucleic acids can include, e.g., DNA or RNA. Systems and devices for use in practicing methods of the invention are also provided.
FILED	Thursday, June 25, 2015
APPL NO	15/317393
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/686 (20130101) Original (OR) Class C12Q 1/686 (20130101) C12Q 1/689 (20130101) C12Q 1/6886 (20130101) C12Q 2563/107 (20130101) C12Q 2563/159 (20130101) C12Q 2565/629 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101)
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10697019 — Method of diagnosis and prognosis

US 10697019	Franzoso et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Guido Franzoso (London, United Kingdom); Laura Tornatore (London, United Kingdom); Menotti Ruvo (San Nicola la Strada, Italy); Alberto Rocci (Turin, Italy); Antonio Palumbo (Turin, Italy)
ASSIGNEE(S)	IMPERIAL COLLEGE INNOVATIONS LIMITED (London, United Kingdom)
INVENTOR(S)	Guido Franzoso (London, United Kingdom); Laura Tornatore (London, United Kingdom); Menotti Ruvo (San Nicola la Strada, Italy); Alberto Rocci (Turin, Italy); Antonio Palumbo (Turin, Italy)
ABSTRACT	A method of measuring Gadd45β expression comprising the step of measuring Gadd45β expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45β and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects.
FILED	Friday, April 27, 2012
APPL NO	14/113518
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101)
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10697020 — MicroRNA-129 as a biomarker for colorectal cancer

US 10697020	Ju et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York)
ASSIGNEE(S)	The Research Foundation for The State University of New York (Albany, New York)
INVENTOR(S)	Jingfang Ju (East Setauket, New York); Mihriban Karaayvaz (Stony Brook, New York); Haiyan Zhai (Holtsville, New York)
ABSTRACT	The current disclosure describes methods for identifying subjects that would benefit from treatment with a chemotherapeutic agent. The disclosure is based in part on the observation that miR-129 expression levels are reduced in colorectal cancer. Accordingly, the current disclosure provides therapeutic compositions and methods for altering the expression of a miR-129 effector. Described herein are methods for characterizing the stage of colorectal cancer in a subject, based on the levels of miR-129 expression. The disclosure also identifies miR-129 as a predictive biomarker for cancer diagnosis and the subsequent treatment with directed therapeutic agents including but not limited to miR-129 nucleic acid molecules and/or a chemotherapeutic agent. The current disclosure also identifies novel therapeutic agents that modulate the level of BCL2, TS and/or E2F3 expression, as well as sensitize a subject to treatment with a chemotherapeutic agent.
FILED	Wednesday, May 14, 2014
APPL NO	14/889212
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/513 (20130101) A61K 31/513 (20130101) A61K 31/7088 (20130101) A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 31/7105 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/487 (20130101)
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10697023 — Systems and methods for providing personalized radiation therapy

US 10697023	Scott et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida)
ASSIGNEE(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida)
INVENTOR(S)	Jacob Scott (Tampa, Florida); Javier F. Torres-Roca (St. Petersburg, Florida)
ABSTRACT	An example method of treating a subject having a tumor is described herein. The method can include determining a radiosensitivity index of the tumor, deriving a subject-specific variable based on the radiosensitivity index, and obtaining a genomic adjusted radiation dose effect value for the tumor. The radiosensitivity index can be assigned from expression levels of signature genes of a cell of the tumor. Additionally, the genomic adjusted radiation dose effect value can be predictive of tumor recurrence in the subject after treatment. The method can also include determining a radiation dose based on the subject-specific variable and the genomic adjusted radiation dose effect value.
FILED	Thursday, May 05, 2016
APPL NO	15/571617
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1031 (20130101) A61N 2005/1032 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101)
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10697026 — Compositions and methods for characterizing a DNA repair variant polypeptide

US 10697026	Scully et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (Boston, Massachusetts)
ASSIGNEE(S)	BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (Boston, Massachusetts)
INVENTOR(S)	Ralph Scully (Boston, Massachusetts); Nicholas A. Willis (Boston, Massachusetts)
ABSTRACT	As described below, the present invention provides quantitative homologous recombination assays developed to characterize the pathogenicity DNA repair polypeptides (e.g., BRCA1, BRCA2, Rad51) and provide urgently needed functional information on the significance of DNA repair variants of uncertain significance (VUS) alleles. The invention also provides a method of generating site-specific recombination at a genomic locus or site-specific genome editing by inhibiting replication at the genomic locus, e.g., involving contacting the genomic locus with polypeptides that specifically bind target sequences at the genomic locus.
FILED	Friday, July 06, 2018
APPL NO	16/028600
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/907 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101)
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10697028 — Detection of HIV-1 nucleic acids by reverse-transcription loop-mediated isothermal amplification

US 10697028	Curtis et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Kelly A. Curtis (Atlanta, Georgia); Sherry M. Owen (Atlanta, Georgia); Philip Niedzwiedz (Atlanta, Georgia); Donna L. Rudolph (Atlanta, Georgia)
ABSTRACT	Disclosed herein are methods of detecting HIV-1 nucleic acids in a sample (such as from a sample containing or suspected to contain HIV-1 nucleic acid). In some examples, the methods include loop-mediated isothermal amplification (LAMP) or reverse transcription-LAMP (RT-LAMP). In some examples, the methods include contacting a sample with one or more sets of LAMP primers specific for HIV-1 (such as LAMP primers specific for an HIV-1 integrase nucleic acid or LAMP primers specific for an HIV-1 reverse transcriptase nucleic acid) under conditions sufficient to produce an amplification product and detecting the amplification product. Sets of LAMP primers for detection of HIV-1 integrase nucleic acids (such as SEQ ID NOs: 8-14 or 8-27) and HIV-1 reverse transcriptase nucleic acids (such as SEQ ID NOs: 1-7) are provided herein.
FILED	Wednesday, October 28, 2015
APPL NO	15/524209
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/703 (20130101) Original (OR) Class C12Q 1/6853 (20130101) C12Q 1/6876 (20130101) C12Q 2600/16 (20130101)
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10697866 — Compositions and methods for laser capture microdissection

US 10697866	Liotta et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	GEORGE MASON RESEARCH FOUNDATION, INC. (Fairfax, Virginia)
ASSIGNEE(S)	GEORGE MASON RESEARCH FOUNDATION, INC. (Fairfax, Virginia)
INVENTOR(S)	Lance Liotta (Bethesda, Maryland); Virginia Espina (Rockville, Maryland); Nitin Agrawal (Fairfax, Virginia); Alessandra Luchini (Burke, Virginia)
ABSTRACT	Compositions and methods for the simulataneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.
FILED	Friday, April 26, 2019
APPL NO	16/396191
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2813 (20130101) Original (OR) Class G01N 2001/284 (20130101)
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10697869 — Systems, devices, and methods for improved tissue treatment

US 10697869	Fiorelli et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	DIGNITY HEALTH (Phoenix, Arizona)
ASSIGNEE(S)	Dignity Health (Phoenix, Arizona)
INVENTOR(S)	Roberto Fiorelli (Scottsdale, Arizona); Gurpaul Singh Sidhu (Chandler, Arizona)
ABSTRACT	Provided herein are systems, devices, and methods for improved treatment of tissue, such as brain tissue. The improved treatment described herein can result in improved tissue penetration of various compounds and chemicals, such as stains and immunohistochemistry reagents. For example, provided herein is a pressurizing device that may include a chamber body having an opening in one of a top and a sidewall of the body, and may also include a chamber lid covering the opening and releasably coupled to the chamber body proximate the opening. The chamber lid and chamber body form an air-tight cavity. The pressurizing device may also have an inlet passing through one of the chamber body and the chamber lid and into the air-tight cavity. The device may also include a retainer coupled inside the air-tight cavity and configured to releasably couple to at least one tissue sample receptacles.
FILED	Monday, April 29, 2019
APPL NO	16/397480
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 1/31 (20130101) Original (OR) Class
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10697871 — Particle isolation/enrichment using continuous closed-loop micro-fluidics

US 10697871	Ryu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Hyunryul Ryu (Boston, Massachusetts); Kyungyong Choi (Cambridge, Massachusetts); Jongyoon Han (Bedford, Massachusetts)
ABSTRACT	The present invention encompasses a micro-fluidic system having a closed-loop configuration in which inertial micro-fluidic separation of particles and/or cells is continuously repeated by feeding part of the output back to the input so that the purity and/or concentration of the particles and/or cell is maximized. The invention also includes methods of using the micro-fluidic system.
FILED	Friday, October 06, 2017
APPL NO	15/726746
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 3/502776 (20130101) B01L 2200/0631 (20130101) B01L 2200/0652 (20130101) B01L 2300/088 (20130101) B01L 2300/0864 (20130101) B01L 2300/0883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4077 (20130101) Original (OR) Class G01N 15/1056 (20130101) G01N 2001/4088 (20130101) G01N 2015/1006 (20130101) G01N 2015/1081 (20130101) G01N 2015/1087 (20130101)
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10697956 — Method for assessment of hepatic function and portal blood flow

US 10697956	Everson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Regents of the University of Colorado (Denver, Colorado)
ASSIGNEE(S)	The Regents of the University of Colorado (Denver, Colorado)
INVENTOR(S)	Gregory Thomas Everson (Englewood, Colorado); Steve Mark Helmke (Denver, Colorado)
ABSTRACT	A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.
FILED	Friday, January 11, 2019
APPL NO	16/246174
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/05 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/49 (20130101) Original (OR) Class G01N 33/92 (20130101) G01N 2800/085 (20130101) Technologies for Adaptation to Climate Change Y02A 90/26 (20180101)
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10697963 — Nucleic acids encoding antibodies with high affinity for Alpha-Klotho

US 10697963	Sidhu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Governing Council of the University of Toronto (Toronto, Canada); Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	The Governing Council of the University of Toronto (Toronto, Canada); Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Sachdev S. Sidhu (Toronto, Canada); Sarah L. Barker (Toronto, Canada); Orson W. Moe (Dallas, Texas); Makoto Kuro-o (Dallas, Texas)
ABSTRACT	An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a αKlotho polypeptide, optionally a folded αKlotho or optionally with a dissociation constant (K_D) of about 2 nM or less, as measured by competitive ELISA assay, methods of making and using to diagnose kidney diseases.
FILED	Tuesday, January 29, 2019
APPL NO	16/261141
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/71 (20130101) C07K 16/28 (20130101) C07K 16/40 (20130101) C07K 2317/51 (20130101) C07K 2317/56 (20130101) C07K 2317/92 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Enzymes C12Y 302/01031 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 33/6872 (20130101) G01N 2333/924 (20130101) G01N 2800/52 (20130101) G01N 2800/347 (20130101)
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10697974 — Methods and compositions for protein identification

US 10697974	Woo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Sungwook Woo (Chestnut Hill, Massachusetts); Peng Yin (Brookline, Massachusetts)
ABSTRACT	Provided herein, in some embodiments, are methods and compositions for protein identification.
FILED	Friday, July 21, 2017
APPL NO	16/319681
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6818 (20130101) Original (OR) Class G01N 2458/10 (20130101)
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10697975 — Methods for identifying, diagnosing, and predicting survival of lymphomas

US 10697975	Staudt et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); Board of Regents of the University of Nebraska (Lincoln, Nebraska); University of Rochester (Rochester, New York); Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona); Universitat de Barcelona (Barcelona, Spain); Fundacio Clinic (Barcelona, Spain); Hospital Clinic de Barcelona (Barcelona, Spain); Julius-Maximilians-University of Wurzburg (Wurzburg, Germany); British Columbia Cancer Agency Branch (Vancouver, Canada); Oslo University Hospital HF (Oslo, Norway); Queen Mary and Westfield College, University of London (London, United Kingdom)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); Board of Regents of the University of Nebraska (Lincoln, Nebraska); University of Rochester (Rochester, New York); Arizona Board of Regents on behalf of the University of Arizona (Tuscon, Arizona); Universitat de Barcelona (Barcelona, Spain); Fundacio Clinic (Barcelona, Spain); Hospital Clinic de Barcelona (Barcelona, Spain); Julius-Maximilians-University of Würzburg (Würzburg, Germany); British Columbia Cancer Agency Branch (Vancouver, Canada); Oslo University Hospital HF (Oslo, Norway); Queen Mary and Westfield College, University of London (London, United Kingdom)
INVENTOR(S)	Louis M. Staudt (Bethesda, Maryland); George Wright (Rockville, Maryland); Sandeep Dave (Chapel Hill, North Carolina); Bruce Tan (Chicago, Illinois); John I. Powell (Ijamsville, Maryland); Wyndham Wilson (Washington, District of Columbia); Elaine S. Jaffe (Great Falls, Virginia); Wing C. Chan (Pasadena, California); Timothy C. Greiner (Council Bluffs, Iowa); Dennis Weisenburger (Glendora, California); James Armitage (Omaha, Nebraska); Kai Fu (Omaha, Nebraska); Richard I. Fisher (Pittsford, New York); Lisa M. Rimsza (Scottsdale, Arizona); Thomas Miller (Tucson, Arizona); Thomas Grogan (Tucson, Arizona); Elias Campo Guerri (Barcelona, Spain); Silvia M. Bea (Sabadell, Spain); Itziar Salaverria (Barcelona, Spain); Armando Lopez-Guillermo (Barcelona, Spain); Emilio Montserrat (Barcelona, Spain); Victor Moreno (Barcelona, Spain); Andreas Zettl (Wurzburg, Germany); German Ott (Bietigheim-Bissingen, Germany); Hans-Konrad Muller-Hermelink (Wurzburg, Germany); Andreas Rosenwald (Wurzburg, Germany); Julie Vose (Omaha, Nebraska); Randy Gascoyne (North Vancouver, Canada); Joseph Connors (Vancouver, Canada); Erlend B. Smeland (Oslo, Norway); Stein Kvaloy (Oslo, Norway); Harald Holte (Oslo, Norway); Jan Delabie (Toronto, Canada); T. Andrew Lister (London, United Kingdom)
ABSTRACT	Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
FILED	Thursday, June 22, 2017
APPL NO	15/630751
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) Original (OR) Class G01N 2333/51 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 40/00 (20190201) Technologies for Adaptation to Climate Change Y02A 90/26 (20180101)
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10697977 — Mass spectrometry-cleavable cross-linker

US 10697977	Huang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of The University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Lan Huang (Irvine, California); Scott D. Rychnovsky (Irvine, California); Clinton Yu (Laguna Hills, California); Eric James Novitsky (Irvine, California); Craig Bryant Gutierrez (Irvine, California)
ABSTRACT	Provided herein is synthesis of a novel acidic acid residue targeting sulfoxide-containing MS-cleavable homobifunctional cross-linker. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also disclosed herein are data based on the novel MS-cleavable homobifunctional cross-linker that are complimentary to amine-reactive sulfoxide-containing MS-cleavable reagents.
FILED	Friday, June 02, 2017
APPL NO	15/613065
ART UNIT	1622 — Organic Chemistry
CURRENT CPC	Separation B01D 15/34 (20130101) Acyclic or Carbocyclic Compounds C07C 315/04 (20130101) C07C 315/04 (20130101) C07C 317/44 (20130101) C07C 317/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) G01N 33/6848 (20130101) Original (OR) Class G01N 2030/8831 (20130101) G01N 2560/00 (20130101)
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10698046 — Magnetic-resonance transceiver-phased array that compensates for reactive and resistive components of mutual impedance between array elements and circuit and method thereof

US 10698046	Avdievich et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Transarray LLC (Lexington, Massachusetts)
ASSIGNEE(S)	Transarray LLC (Lexington, Massachusetts)
INVENTOR(S)	Nikolai I. Avdievich (Bronx, New York); Hoby P. Hetherington (Woodbridge, Connecticut); Jullie W. Pan (Woodbridge, Connecticut)
ABSTRACT	There is provided a novel method and circuit of compensating for cross-talk between pairs of adjacent array elements of a transceiver phased array and double-tuned transceiver arrays for a magnetic resonance system using a resonant inductive decoupling circuit. The geometry and size of the resonant inductive decoupling circuit allows for the decoupling circuit to compensate for the cross-talk between array elements, including the reactive and resistive components of the mutual impedance while being sufficiently small to not distort a RF magnetic field of the array elements produced within a sample.
FILED	Monday, March 25, 2019
APPL NO	16/363530
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/365 (20130101) G01R 33/3415 (20130101) G01R 33/3635 (20130101) G01R 33/3642 (20130101) Original (OR) Class
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10698053 — System and method for gradient-modulated sweep imaging with fourier transformation magnetic resonance imaging

US 10698053	Zhang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR)
APPLICANT(S)	Jinjin Zhang (Minneapolis, Minnesota); Michael Garwood (Minneapolis, Minnesota); Djaudat Idiyatullin (Minneapolis, Minnesota); Curt Corum (Minneapolis, Minnesota); Naoharu Kobayashi (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Jinjin Zhang (Minneapolis, Minnesota); Michael Garwood (Minneapolis, Minnesota); Djaudat Idiyatullin (Minneapolis, Minnesota); Curt Corum (Minneapolis, Minnesota); Naoharu Kobayashi (Minneapolis, Minnesota)
ABSTRACT	Described here are systems and methods for magnetic resonance imaging (“MRI”) using a sweeping frequency excitation applied during a time-varying magnetic field gradient. As an example, a gradient-modulated offset independent adiabaticity (“GOIA”) approach can be used to modify the pattern of the sweeping frequency excitation. Data are acquired as time domain signals and processed to generate images. As an example, the time domain signals are processed using a correlation between a Fourier transform of the gradient-modulated sweeping frequency excitation and a Fourier transform of the time domain signals.
FILED	Monday, February 09, 2015
APPL NO	14/617616
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4816 (20130101) Original (OR) Class
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10698056 — Magnetic resonance magnification imaging

US 10698056	Shen
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, Maryland)
INVENTOR(S)	Jun Shen (Bethesda, Maryland)
ABSTRACT	One aspect of the present disclosure provides an imaging method including: specifying an imaging focus region on a subject to be imaged, applying radiofrequency pulses to the subject to interact with a magnetic field gradient, wherein the radiofrequency pulses successively bend magnetization phases of respective electromagnetic signals from the specified imaging focus region, resulting in magnified pixel data, and generating a magnified image of the imaging focus region based on the magnified pixel data.
FILED	Friday, October 02, 2015
APPL NO	15/516339
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/54 (20130101) G01R 33/58 (20130101) G01R 33/483 (20130101) G01R 33/543 (20130101) G01R 33/546 (20130101) G01R 33/4833 (20130101) Original (OR) Class G01R 33/5604 (20130101)
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10701662 — Methods and apparatus for wideband localization

US 10701662	Luo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Zhihong Luo (Berkeley, California); Qiping Zhang (Austin, Texas); Nicholas Selby (Cambridge, Massachusetts); Yunfei Ma (Santa Clara, California); Manish Singh (Delhi, India); Fadel Adib (Cambridge, Massachusetts)
ABSTRACT	A wideband, radio-frequency localization system may estimate the one-dimensional, two-dimensional or three-dimensional position and trajectory of a static or moving object. These estimates may have a high spatial accuracy and low latency. The localization may be determined based on phase or amplitude of a wideband signal in each frequency band in a set of multiple frequency bands. The localization may be based on a single shot of measurements across a wide band of radio frequencies, without frequency hopping. The measurements of the wideband signal may be taken over time and over space at multiple receivers. The localization may be based on measurements taken while a backscatter node remains in a first reflective state or in a second reflective state, rather than when the backscatter node is transitioning between reflective states. In some cases, the localization achieves sub-centimeter spatial resolution in each of three spatial dimensions.
FILED	Thursday, December 26, 2019
APPL NO	16/727727
ART UNIT	2643 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0221 (20130101) G01S 5/0278 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0007 (20130101) H04L 27/265 (20130101) Wireless Communication Networks H04W 64/006 (20130101) Original (OR) Class
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Department of Defense (DOD)

10694739 — Compositions and methods for reducing ice crystal formation

US 10694739	Wei
FUNDED BY	Department of Defense (DOD) Defense Health Agency (DHA)
APPLICANT(S)	X-Therma, Inc. (Richmond, California)
ASSIGNEE(S)	X-THERMA, INC. (Richmond, California)
INVENTOR(S)	Xiaoxi Wei (El Cerrito, California)
ABSTRACT	The present invention provides peptoid polymers capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids comprising the peptoid polymers provided herein. The peptoid polymers and peptoid-peptide hybrids provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.
FILED	Wednesday, May 02, 2018
APPL NO	15/969256
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class Preserving, e.g by Canning, Meat, Fish, Eggs, Fruit, Vegetables, Edible Seeds; Chemical Ripening of Fruit or Vegetables; the Preserved, Ripened, or Canned Products A23B 4/20 (20130101) Cocoa; Cocoa Products, e.g Chocolate; Substitutes for Cocoa or Cocoa Products; Confectionery; Chewing Gum; Ice-cream; Preparation Thereof A23G 9/32 (20130101) A23G 9/38 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 3/37 (20130101) A23L 3/3526 (20130101) A23L 13/42 (20160801) A23L 17/00 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 8/64 (20130101) A61K 8/88 (20130101) A61K 2800/54 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 90/00 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/001 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/10 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 3/18 (20130101)
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10695402 — Erythropoietin for gastrointestinal dysfunction

US 10695402	Elfar et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	University of Rochester (Rochester, New York)
ASSIGNEE(S)	UNIVERSITY OF ROCHESTER (Rochester, New York)
INVENTOR(S)	John Elfar (Rochester, New York); Walaa Elfar (Rochester, New York); Mark Noble (Rochester, New York)
ABSTRACT	This invention relates to treating gastrointestinal dysfunction with erythropoietin (EPO) or its analog.
FILED	Friday, March 16, 2018
APPL NO	15/923275
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1816 (20130101) Original (OR) Class A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/14 (20180101)
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10695482 — Cartridge and method for increasing myocardial function

US 10695482	Humes et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	SeaStar Medical, Inc. (Cardiff-By-The-Sea, California)
ASSIGNEE(S)	SeaStar Medical, Inc. (Cardiff-by-the-Sea, California)
INVENTOR(S)	H. David Humes (Ann Arbor, Michigan); Deborah A. Buffington (Ann Arbor, Michigan); Christopher J. Pino (Saline, Michigan)
ABSTRACT	The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions that affect myocardial function and to related methods. The cartridge can be used in treating a subject with myocardial dysfunction, such as a subject with chronic heart failure and/or acute decompensated heart failure.
FILED	Tuesday, June 20, 2017
APPL NO	15/628071
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/194 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/16 (20130101) A61M 1/34 (20130101) A61M 1/1625 (20140204) A61M 1/3472 (20130101) A61M 1/3486 (20140204) Original (OR) Class A61M 1/3666 (20130101) A61M 1/3679 (20130101) A61M 1/3687 (20130101) A61M 2202/0427 (20130101) A61M 2202/0439 (20130101) A61M 2205/126 (20130101) A61M 2210/125 (20130101)
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10695742 — Reforming with oxygen-enriched matter

US 10695742	DuBois
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Terry DuBois (Forest Hill, Maryland)
ABSTRACT	Various embodiments that pertain to oxygen enrichment are described. Oxygen enrichment is shown to allow for independent control of both reformer residence time and the oxygen-to-carbon ratio during reforming. This allows for much better control over the reformer and for significant gains in reformer through-put without negative impacts to reformer performance. Additionally, the use of oxygen enriched reforming is shown to result in enhanced reformer performance, reduced degradation from catalyst poisons (carbon formation and sulfur) and enhanced fuel cell stack performance due to greatly increased hydrogen concentration in the reformate.
FILED	Thursday, April 12, 2018
APPL NO	15/951212
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 12/007 (20130101) B01J 19/0013 (20130101) B01J 19/24 (20130101) Original (OR) Class B01J 2219/24 (20130101) B01J 2219/00063 (20130101) B01J 2219/00065 (20130101) B01J 2219/00069 (20130101) B01J 2219/00087 (20130101) B01J 2219/00117 (20130101) B01J 2219/00159 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/38 (20130101) C01B 13/0251 (20130101) C01B 2203/0227 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101)
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10696386 — Rigid rotor head with tension torsion (TT) strap retention

US 10696386	Miner et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Aviation and Missile Center (CCDC AVMC)
APPLICANT(S)	Sikorsky Aircraft Corporation (Stratford, Connecticut)
ASSIGNEE(S)	SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut)
INVENTOR(S)	Frederick J. Miner (Barkhamsted, Connecticut); David A. Darrow (Mesa, Arizona); Stephen V. Poulin (Milford, Connecticut); Richard Thomas Hood (Fairfield, Connecticut); Frank P. D'Anna (Seymour, Connecticut)
ABSTRACT	A box frame hub arm structure is provided and includes a body having an outboard surface, which is disposable to abut with an inboard surface of an outboard arm of an aircraft rotor head, and lead/lag sides. The body is formed to define a first cavity, an aperture communicative with the first cavity through the outboard surface and second and third cavities. The second and third cavities extend outwardly in opposite lead/lag directions from the first cavity to the lead/lag sides.
FILED	Friday, August 12, 2016
APPL NO	15/765119
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 11/06 (20130101) B64C 27/33 (20130101) B64C 27/48 (20130101) B64C 27/327 (20130101) Original (OR) Class
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10696425 — System for imparting linear momentum transfer for higher orbital insertion

US 10696425	Hickman
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Robert Alan Hickman (Chapel Hill, North Carolina)
ABSTRACT	A system for imparting linear momentum transfer may include a catching mechanism of a target space vehicle and a tether that is configured to impart a linear momentum transfer from the tether to the target space vehicle. The tether may be fixedly or detachably connected to a Kinetic Energy Storage and Transfer (KEST) vehicle that maneuvers and potentially retrieves the tether. Alternatively, the tether may be separate from the KEST vehicle and may be retrieved by a suitable retrieving mechanism, such as a robotic arm.
FILED	Wednesday, May 10, 2017
APPL NO	15/591726
ART UNIT	3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/002 (20130101) B64G 1/005 (20130101) B64G 1/007 (20130101) B64G 1/36 (20130101) B64G 1/40 (20130101) B64G 1/242 (20130101) Original (OR) Class B64G 1/402 (20130101) B64G 1/405 (20130101) B64G 1/646 (20130101) B64G 1/648 (20130101)
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10696541 — Systems and methods for bias suppression in a non-degenerate MEMS sensor

US 10696541	Endean et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	Honeywell International Inc. (Morris Plains, New Jersey)
INVENTOR(S)	Daniel Endean (Plymouth, Minnesota); John Reinke (Plymouth, Minnesota)
ABSTRACT	Systems and methods for suppressing bias in a non-degenerate vibratory structure are provided. In certain embodiments, a vibratory structure includes a first proof mass; a second proof mass, wherein the first proof mass and the second proof mass are driven into motion along a first axis, wherein the first proof mass and the second proof mass move in anti-phase along a second axis, wherein the motion of the first proof mass and the second proof mass along the second axis is such that the centers of mass of the first proof mass and the second proof mass move collinearly along a same axis.
FILED	Wednesday, March 22, 2017
APPL NO	15/466778
ART UNIT	2861 — Printing/Measuring and Testing
CURRENT CPC	Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0021 (20130101) Original (OR) Class B81B 3/0072 (20130101) B81B 7/0058 (20130101) B81B 2201/0242 (20130101) B81B 2203/0118 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/574 (20130101) G01C 19/5719 (20130101) G01C 19/5747 (20130101)
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10696733 — Microbe-binding molecules and uses thereof

US 10696733	Watters et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON)
APPLICANT(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S)	Alexander Watters (North Andover, Massachusetts); Brendon Dusel (West Roxbury, Massachusetts); Michael Super (Lexington, Massachusetts); Mark Cartwright (West Newton, Massachusetts); Donald E. Ingber (Boston, Massachusetts)
ABSTRACT	Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
FILED	Wednesday, August 28, 2019
APPL NO	16/553635
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/00 (20130101) C07K 14/78 (20130101) Original (OR) Class C07K 14/4726 (20130101) C07K 19/00 (20130101) C07K 2319/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/569 (20130101) G01N 2333/78 (20130101) G01N 2400/00 (20130101)
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10696786 — Methods of producing energetic polymers, energetic binders, and energetic compositions

US 10696786	Straessler et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Northrop Grumman Innovation Systems, Inc. (Plymouth, Minnesota)
ASSIGNEE(S)	Northrop Grumman Innovation Systems, Inc. (Plymouth, Minnesota)
INVENTOR(S)	Nicholas A. Straessler (North Salt Lake, Utah); Michael O. Killpack (Brigham City, Utah); Daniel W. Doll (Culpeper, Virginia)
ABSTRACT	A method of producing an energetic polymer comprises reacting at least one energetic diol with at least one of a diacid halide and a diacid halide derivative to produce a geminal dinitro polyester. A method of producing an energetic binder, and a method of producing an energetic composition are also described.
FILED	Thursday, December 11, 2014
APPL NO	14/567334
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 25/00 (20130101) C06B 25/04 (20130101) C06B 25/34 (20130101) C06B 45/105 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/463 (20130101) C08G 63/16 (20130101) Original (OR) Class C08G 63/685 (20130101) C08G 63/916 (20130101)
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10697023 — Systems and methods for providing personalized radiation therapy

US 10697023	Scott et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida)
ASSIGNEE(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida)
INVENTOR(S)	Jacob Scott (Tampa, Florida); Javier F. Torres-Roca (St. Petersburg, Florida)
ABSTRACT	An example method of treating a subject having a tumor is described herein. The method can include determining a radiosensitivity index of the tumor, deriving a subject-specific variable based on the radiosensitivity index, and obtaining a genomic adjusted radiation dose effect value for the tumor. The radiosensitivity index can be assigned from expression levels of signature genes of a cell of the tumor. Additionally, the genomic adjusted radiation dose effect value can be predictive of tumor recurrence in the subject after treatment. The method can also include determining a radiation dose based on the subject-specific variable and the genomic adjusted radiation dose effect value.
FILED	Thursday, May 05, 2016
APPL NO	15/571617
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1031 (20130101) A61N 2005/1032 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101)
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10697309 — Platform cover plates for gas turbine engine components

US 10697309	Anderson et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Corey D. Anderson (East Hartford, Connecticut); Brandon W. Spangler (Vernon, Connecticut)
ABSTRACT	Components for gas turbine engines are provided. The components include a platform, a first airfoil extending from the platform, a first cavity located within the first airfoil, the first cavity includes a forward portion and an aft portion separated by a divider, a cover plate attached to the platform on a side opposite the airfoil, wherein a platform cavity is defined between the cover plate and the platform and wherein the first cavity is fluidly connected to the platform cavity through a first cavity inlet, and a first cavity separating rail dividing the platform cavity into a first platform forward cavity and a first platform aft cavity, wherein the first platform forward cavity is fluidly connected to the aft portion of the first cavity and the first platform aft cavity is fluidly connected to the forward portion of the first cavity.
FILED	Wednesday, April 25, 2018
APPL NO	15/961930
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/188 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/12 (20130101) F05D 2250/70 (20130101) F05D 2260/201 (20130101)
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10697321 — Vented tangential on-board injector for a gas turbine engine

US 10697321	McCaffrey
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Michael G. McCaffrey (Windsor, Connecticut)
ABSTRACT	An on-board injector that delivers discharge air toward a turbine rotor of a gas turbine engine includes a second wall spaced form a first wall to define an annular inlet about an engine longitudinal axis and a multiple of airfoil shapes between the first wall and the second wall to segregate discharge air from the annular inlet, and a multiple of bypass apertures each along a radial axis transverse to the engine longitudinal axis through each of the multiple of airfoil shapes and the respective first wall, the second wall.
FILED	Tuesday, March 06, 2018
APPL NO	15/913269
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 1/02 (20130101) F01D 5/081 (20130101) F01D 5/087 (20130101) F01D 11/001 (20130101) F01D 11/02 (20130101) F01D 11/025 (20130101) F01D 25/12 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/18 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/14 (20130101) F05D 2260/601 (20130101) F05D 2260/6022 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/673 (20130101) Y02T 50/676 (20130101)
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10697742 — Multiple payload expendable device

US 10697742	Dube et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	QUAD-M, INC. (McDade, Texas)
ASSIGNEE(S)	QUAD-M, INC. (McDade, Texas)
INVENTOR(S)	Victor James Dube (McDade, Texas); Tyler Holden (Bastrop, Texas); Beryl W. Cotton (Lexington, Texas)
ABSTRACT	This disclosure relates generally to a Multiple Payload Expendable Device consisting of a set of cylindrical multiple payload casings, each payload casing exhibiting circular symmetry fluid passages in relation to firing squibs and voltage coded squib actuating circuit that converts existing single payload expendable device systems to multiple payload expendable device systems.
FILED	Wednesday, January 30, 2019
APPL NO	16/262799
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 5/15 (20130101) Original (OR) Class
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10697915 — Sensor for determining a physicochemical property of a liquid fuel

US 10697915	Junaedi et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Aerospace Systems Directorate (AFRL/RQ) Turbine Engine Division (AFRL/RQT)
APPLICANT(S)	PRECISION COMBUSTION, INC. (North Haven, Connecticut)
ASSIGNEE(S)	PRECISION COMBUSTION, INC. (North Haven, Connecticut)
INVENTOR(S)	Christian Junaedi (Cheshire, Connecticut); Subir Roychoudhury (Madison, Connecticut)
ABSTRACT	A portable, compact, real-time and accurate sensor and method for deriving a physicochemical property of a liquid fuel, such as cetane number, carbon content, carbon/hydrogen (C/H) atomic ratio, or heating value (net heat of combustion). The sensor comprises a constant-volume ignition chamber equipped for measuring ignition delay and magnitude of a peak rise in pressure or temperature following dispensation of a liquid fuel into the chamber. The sensor utilizes air at atmospheric pressure and microliter quantities of fuel. The sensor can be implemented in real-time refinery operations for blending diesel fuels that meet government mandated cetane number standards as well as in applications for standardizing jet, biodiesel, and synthetic fuels, which presently are not classified by any physicochemical property.
FILED	Friday, May 26, 2017
APPL NO	15/606077
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/28 (20130101) Original (OR) Class G01N 33/22 (20130101)
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10697918 — Polymer / single-walled carbon nanotube composite for gas detection

US 10697918	Swager et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Timothy Manning Swager (Newton, Massachusetts); Sophie Liu (Annandale, New Jersey); Bora Yoon (Cambridge, Massachusetts)
ABSTRACT	A sensor can include a conductive region in electrical communication with at least two electrodes, the conductive region can include a composite of a polymer and SWCNTs immobilized onto a substrate. In certain embodiment, a linker can be grafted on the substrate. The linker can connect the substrate and the composite of the polymer and SWCNTs. In certain embodiments, the linker can covalently bond the polymer to the substrate. In certain embodiments, metal nanoparticles or ions can be incorporated as a metal sensitizer to confer further selectivity or sensitivity to the device. In certain embodiments, the polymer can act as a ligand for a variety of metal ions. By incorporating a specific metal ion, the sensor can selectively detect a specific analyte. In certain embodiments, the composite of the polymer and SWCNTs can be functionalized. In certain embodiments, the composite can further include a sensing element.
FILED	Thursday, May 04, 2017
APPL NO	15/586466
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/168 (20170801) C01B 2202/02 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/44 (20130101) C08F 8/44 (20130101) C08F 38/02 (20130101) C08F 126/06 (20130101) C08F 126/06 (20130101) Compositions of Macromolecular Compounds C08L 39/04 (20130101) C08L 39/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/126 (20130101) Original (OR) Class G01N 27/127 (20130101) G01N 27/4162 (20130101)
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10698039 — Electrical current connector

US 10698039	Podlesak et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Thomas Podlesak (Elkton, Maryland); Michael Gonzalez (Bel Air, Maryland)
ABSTRACT	Various embodiments are described that relate an electrical current connector. The electrical current connector can be configured to provide electrical current when pressure is applied to a prong set. This pressure can cause a contact to engage with a connector. This can complete a circuit that allows the electrical current to flow. The connector can be coupled to a cable that can be configured to transfer data along with the electrical current. The cable can have an inner portion that transfers the data while an outer portion that surrounds the inner portion transfers the current.
FILED	Thursday, October 12, 2017
APPL NO	15/730859
ART UNIT	2868 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 31/50 (20200101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/193 (20130101) H01R 13/641 (20130101) H01R 13/6683 (20130101) H01R 13/7038 (20130101)
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10698077 — Angle-based multiple-source geolocation method and geolocation geometry evaluation based on covariance matrix

US 10698077	Oden
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC)
APPLICANT(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Mark W. Oden (Nashua, New Hampshire)
ABSTRACT	A computer-implemented method of geolocating a target includes: receiving, from a plurality of sources, a corresponding plurality of angle estimates of the target relative to the respective sources; generating a corresponding plurality of planar renditions of the received angle estimates; selecting a combination of two or more planar renditions whose intersection defines a polygon; in response to multiple such combinations, selecting one having a largest number of planar renditions; and determining a center of the polygon of the selected combination. A computer-implemented method of evaluating geolocation geometry with respect to a target includes: geolocating the target from received sensor data of the target from multiple sources and location data of the sources; generating entries of a covariance matrix from the location data and the geolocation; deriving eigenvalues of the covariance matrix from the generated entries; and comparing the derived eigenvalues to evaluate the geolocation geometry with respect to the target.
FILED	Wednesday, June 26, 2019
APPL NO	16/453281
ART UNIT	2645 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/04 (20130101) Original (OR) Class G01S 5/0221 (20130101)
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10698121 — 10B enriched plastic scintillators for application in thermal neutron detection, methods of making and using the same

US 10698121	Sellinger et al.
FUNDED BY	Department of Homeland Security (DHS) Department of Defense (DOD) Defense Threat Reduction Agency (DTRA)
APPLICANT(S)	Alan Sellinger (Golden, Colorado); Uwe Greife (Golden, Colorado); Henok A. Yemam (Golden, Colorado); Adam Mahl (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S)	Alan Sellinger (Golden, Colorado); Uwe Greife (Golden, Colorado); Henok A. Yemam (Golden, Colorado); Adam Mahl (Denver, Colorado)
ABSTRACT	The present invention relates to a ¹⁰B enriched plastic scintillators, methods of making the same and methods of using the same. Neither carboranes nor ³He are required to be included in the plastic scintillators, which can be used in neutron detection.
FILED	Tuesday, August 07, 2018
APPL NO	16/057793
ART UNIT	2884 — Optics
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Measurement of Nuclear or X-radiation G01T 1/2033 (20130101) Original (OR) Class G01T 3/06 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 4/00 (20130101)
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10698156 — Wafer scale bonded active photonics interposer

US 10698156	Coolbaugh et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	The Research Foundation for The State University of New York (Albany, New York)
ASSIGNEE(S)	The Research Foundation for the State University of New York (Albany, New York)
INVENTOR(S)	Douglas Coolbaugh (Albany, New York); Douglas La Tulipe (Albany, New York); Gerald Leake (Albany, New York)
ABSTRACT	There is set forth herein a method including building an interposer base structure on a first wafer having a first substrate, wherein the building an interposer base structure includes fabricating a plurality of through vias that extend through the first substrate and fabricating within an interposer base dielectric stack formed on the first substrate one or more metallization layer; building a photonics structure on a second wafer having a second substrate, wherein the building a photonics structure includes fabricating within a photonics device dielectric stack formed on the second substrate one or more photonics device; and bonding the photonics structure to the interposer base structure to define an interposer having the interposer base structure and one or more photonics device fabricated within the photonics device dielectric stack. There is set forth herein an optoelectrical system including a substrate; an interposer dielectric stack formed on the substrate, the interposer dielectric stack including a base interposer dielectric stack, and a photonics device dielectric stack, and a bond layer dielectric stack that integrally bonds the photonics device dielectric stack to the base interposer dielectric stack.
FILED	Thursday, February 08, 2018
APPL NO	15/891847
ART UNIT	2893 — Semiconductors/Memory
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/131 (20130101) G02B 6/12002 (20130101) Original (OR) Class G02B 2006/12061 (20130101) G02B 2006/12138 (20130101) G02B 2006/12147 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/486 (20130101) H01L 23/49816 (20130101) H01L 23/49827 (20130101) H01L 23/49838 (20130101) H01L 31/02002 (20130101) H01L 31/02016 (20130101) H01L 31/02327 (20130101)
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10698441 — High-frequency clock distribution and alignment system

US 10698441	Cali et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Joseph D. Cali (Nashua, New Hampshire); Steven E. Turner (Nashua, New Hampshire)
ABSTRACT	A clock distribution and alignment system includes at least three clock generators, each including a clock receiver circuit to receive a first clock signal having a first frequency, and a clock divider circuit to divide the received first clock signal into a second clock signal having a second frequency lower than the first frequency, each of two or more of the clock generators further including a phase detector circuit to compare the phase of the second clock signal with the phase of the second clock signal for a next one of the clock generators, and a clock adjuster circuit to adjust the phase of the received first clock signal based on the compared phases of the second clock signals. In some cases, the clock adjuster circuit is further to align the phases of the second clock signals to within a predefined tolerance of each other.
FILED	Monday, May 21, 2018
APPL NO	15/984841
ART UNIT	2186 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 1/08 (20130101) G06F 1/10 (20130101) G06F 1/12 (20130101) Original (OR) Class
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10698669 — Methods and apparatus for data transfer optimization

US 10698669	Lethin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Reservoir Labs, Inc. (New York, New York)
ASSIGNEE(S)	Reservoir Labs, Inc. (New York, New York)
INVENTOR(S)	Richard A. Lethin (New York, New York); Allen K. Leung (New York, New York); Benoit J. Meister (New York, New York); David E. Wohlford (Portland, Oregon)
ABSTRACT	Methods, apparatus and computer software product for optimization of data transfer between two memories includes determining access to master data stored in one memory and/or to local data stored in another memory such that either or both of the size of total data transferred and the number of data transfers required to transfer the total data can be minimized. The master and/or local accesses are based on, at least in part, respective structures of the master and local data.
FILED	Monday, December 11, 2017
APPL NO	15/837551
ART UNIT	2184 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 8/443 (20130101) Original (OR) Class G06F 12/023 (20130101)
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10698727 — Reducing service downtime during service migration

US 10698727	Abali et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Bulent Abali (Tenafly, New Jersey); Hubertus Franke (Cortlandt Manor, New York); Thai Franck Le (White Plains, New York); Erich M. Nahum (New York, New York)
ABSTRACT	A computer-implemented method is provided for supporting virtual machine and/or container live migration. The method may include hosting a virtual machine (VM) at a first location to be migrated to a second location by sending VM data packets from the first location to the second location and detecting a predetermined event associated with the VM at the first location. The method may further include prompting, in response to detection of the predetermined event, the redirection of the VM data packets from the first location to a buffer associated with the second location and storing the VM data packets in the buffer. The method may further include detecting an end of the predetermined event associated with the first location, and redirecting, in response to the end of the predetermined event, the VM data packets stored in the buffer to the VM migrated to the second location.
FILED	Friday, July 19, 2019
APPL NO	16/516525
ART UNIT	2445 — Computer Networks
CURRENT CPC	Electric Digital Data Processing G06F 9/544 (20130101) G06F 9/4856 (20130101) Original (OR) Class G06F 9/45558 (20130101) G06F 2009/4557 (20130101) G06F 2009/45595 (20130101)
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10698859 — Data multicasting with router replication and target instruction identification in a distributed multi-core processing architecture

US 10698859	Burger et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Doug Burger (Austin, Texas); Stephen W. Keckler (Austin, Texas); Dong Li (Austin, Texas)
ASSIGNEE(S)	The Board of Regents of the University of Texas System (Austin, Texas)
INVENTOR(S)	Doug Burger (Austin, Texas); Stephen W. Keckler (Austin, Texas); Dong Li (Austin, Texas)
ABSTRACT	Methods, procedures, apparatuses, computer programs, computer-accessible mediums, processing arrangements and systems generally related to data multi-casting in a distributed processor architecture are described. Various implementations may include identifying a plurality of target instructions that are configured to receive a first message from a source; providing target routing instructions to the first message for each of the target instructions including selected information commonly shared by the target instructions; and, when two of the identified target instructions are located in different directions from one another relative to a router, replicating the first message and routing the replicated messages to each of the identified target instructions in the different directions. The providing target routing instructions may further comprise the selected information utilizing a subset of bits that is commonly shared by the target instructions and being identified as a left operand, right operand or predicate operand, and may include the selection of one of a plurality of multiple-instruction subsets of the target instructions.
FILED	Friday, September 18, 2009
APPL NO	12/562940
ART UNIT	2183 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 9/3824 (20130101) G06F 9/3885 (20130101) G06F 13/14 (20130101) G06F 15/17312 (20130101) Original (OR) Class G06F 15/17318 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 45/00 (20130101)
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10698964 — System and method for automatically detecting and interactively displaying information about entities, activities, and events from multiple-modality natural language sources

US 10698964	Castelli et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Vittorio Castelli (Yorktown Heights, New York); Radu Florian (Yorktown Heights, New York); Xiaoqiang Luo (Yorktown Heights, New York); Hema Raghavan (Yorktown Heights, New York)
ABSTRACT	A method for automatically extracting and organizing information by a processing device from a plurality of data sources is provided. A natural language processing information extraction pipeline that includes an automatic detection of entities is applied to the data sources. Information about detected entities is identified by analyzing products of the natural language processing pipeline. Identified information is grouped into equivalence classes containing equivalent information. At least one displayable representation of the equivalence classes is created. An order in which the at least one displayable representation is displayed is computed. A combined representation of the equivalence classes that respects the order in which the displayable representation is displayed is produced.
FILED	Monday, January 30, 2017
APPL NO	15/419615
ART UNIT	2657 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 16/35 (20190101) G06F 16/36 (20190101) G06F 16/338 (20190101) G06F 16/3344 (20190101) G06F 16/9535 (20190101) Original (OR) Class G06F 40/295 (20200101)
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10699040 — System and method for remaining useful life determination

US 10699040	Martin et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Autonomous Sustainment Technologies for Rotorcraft Operations Electrical (ASTRO-E)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Charles E. Martin (Thousand Oaks, California); Tsai-Ching Lu (Thousand Oaks, California); Samuel D. Johnson (Santa Monica, California); Steve Slaughter (Scottsdale, Arizona); Alice A. Murphy (Mesa, Arizona); Christopher R. Wezdenko (Mesa, Arizona)
ABSTRACT	A vehicle system prognosis apparatus including sensor(s) for detecting a characteristic of a vehicle system and generating at least one time series of condition indicator values, and a processor that receives the at least one time series and generates an analysis model, for the characteristic, that is trained with one or more of the at least one time series, that are obtained from the one or more sensors with the vehicle system operating under normal conditions, extracts from the at least one time series one or more features embodying an indication of a health of the vehicle system, generates a quantified health assessment of the vehicle system by quantifying the one or more features based on a normal distribution of the one or more features from the analysis model, and communicates the quantified health assessment of the vehicle system to an operator or crew member of the vehicle.
FILED	Monday, August 07, 2017
APPL NO	15/670289
ART UNIT	2127 — AI & Simulation/Modeling
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 23/0229 (20130101) G05B 23/0283 (20130101) Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/0808 (20130101) G07C 5/0825 (20130101)
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10699139 — System for real-time object detection and recognition using both image and size features

US 10699139	Chen et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Yang Chen (Westlake Village, California); Deepak Khosla (Camarillo, California); Ryan M. Uhlenbrock (Camarillo, California)
ABSTRACT	Described is an object recognition system. Using an integral channel features (ICF) detector, the system extracts a candidate target region (having an associated original confidence score representing a candidate object) from an input image of a scene surrounding a platform. A modified confidence score is generated based on a location and height of detection of the candidate object. The candidate target regions are classified based on the modified confidence score using a trained convolutional neural network (CNN) classifier, resulting in classified objects. The classified objects are tracked using a multi-target tracker for final classification of each classified object as a target or non-target. If the classified object is a target, a device can be controlled based on the target.
FILED	Thursday, February 14, 2019
APPL NO	16/276513
ART UNIT	2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/469 (20130101) G06K 9/00744 (20130101) G06K 9/00805 (20130101) Original (OR) Class G06K 9/3233 (20130101) G06K 9/3241 (20130101) G06K 9/6274 (20130101) G06K 9/6292 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101)
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10699886 — System and method for thermionic energy conversion

US 10699886	Schmitt et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	Spark Thermionics, Inc. (Berkeley, California)
ASSIGNEE(S)	Spark Thermionics, Inc. (Berkeley, California)
INVENTOR(S)	Felix Schmitt (Berkeley, California); Jared William Schwede (Berkeley, California); Adam Lorimer (Berkeley, California)
ABSTRACT	A system for thermionic energy generation, preferably including one or more thermionic energy converters, and optionally including one or more power inputs, airflow modules, and/or electrical loads. A thermionic energy converter, preferably including an emitter module, a collector module, and/or a seal, and optionally including a spacer. The thermionic energy converter preferably defines a chamber and/or a heating cavity. A method for thermionic energy generation, preferably including receiving power, emitting electrons, and/or receiving the emitted electrons, and optionally including convectively transferring heat.
FILED	Wednesday, November 06, 2019
APPL NO	16/676131
ART UNIT	2834 — Electrical Circuits and Systems
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) Original (OR) Class
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10700226 — Optically activated transistor, switch, and photodiode

US 10700226	Campbell
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	BOISE STATE UNIVERSITY (Boise, Idaho)
ASSIGNEE(S)	BOISE STATE UNIVERSITY (Boise, Idaho)
INVENTOR(S)	Kristy A. Campbell (Boise, Idaho)
ABSTRACT	An optically activated device that includes an active material on a substrate with two electrodes electrically connected to the active material, the active material conducts current in the presence of light and does not conduct appreciable current in the absence of light. The optically activated device functions as a photodiode, a switch, and an optically gated transistor. The optically activated device conducts current in the presences of light. The active material may be layers of germanium selenide and germanium selenide and an element. Germanium selenide may be sputtered onto a substrate to create layers of material separated by layers of co-sputtered germanium selenide with the element. The active material may be deposited onto a flexible substrate.
FILED	Friday, May 25, 2018
APPL NO	15/990067
ART UNIT	2872 — Optics
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/34 (20130101) C23C 14/0623 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/032 (20130101) H01L 31/109 (20130101) H01L 31/0324 (20130101) Original (OR) Class H01L 31/022408 (20130101)
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10700232 — Inverted metamorphic multijunction solar cells with doped alpha layer

US 10700232	Cho et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	SolAero Technologies Corp. (Albuquerque, New Mexico)
ASSIGNEE(S)	SolAero Technologies Corp. (Albuquerque, New Mexico)
INVENTOR(S)	Benjamin Cho (Albuquerque, New Mexico); Yong Lin (Albuquerque, New Mexico); Pravin Patel (Albuquerque, New Mexico); Mark Stan (Albuquerque, New Mexico); Arthur Cornfeld (Sandy Springs, Georgia); Daniel McGlynn (Albuquerque, New Mexico); Fred Newman (Seattle, Washington)
ABSTRACT	A multijunction solar cell comprising at least a first subcell and a second subcell, a first alpha layer disposed over said first solar subcell grown using a surfactant and dopant including selenium or tellurium, the first alpha layer configured to prevent threading dislocations from propagating; a metamorphic grading interlayer disposed over and directly adjacent to said first alpha layer; a second alpha layer grown using a surfactant and dopant including selenium or tellurium over and disposed directly adjacent to said grading interlayer to prevent threading dislocations from propagating; wherein the second solar subcell is disposed over said grading interlayer such that the second solar subcell is lattice mismatched with respect to the first solar subcell.
FILED	Friday, March 24, 2017
APPL NO	15/468562
ART UNIT	2894 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/078 (20130101) Original (OR) Class H01L 31/0336 (20130101)
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10700255 — High-temperature superconductor teraherz emitting diode

US 10700255	Taylor et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California)
ASSIGNEE(S)
INVENTOR(S)	Benjamin J. Taylor (Escondido, California); Teresa H. Emery (San Diego, California); Susan Berggren (San Diego, California); Anna M. Leese De Escobar (Encinitas, California)
ABSTRACT	A system includes a substrate having a high-temperature superconductor compound film disposed thereon. A first superconducting region is formed within the film and has a first stabilized oxygen content. A second superconducting region is also formed within the film and is located adjacent to the first superconducting region. The second superconducting region has a second stabilized oxygen content. A boundary region is formed within the film and separates the first superconducting region from the second superconducting region. A voltage source is connected to the first superconducting region and the second superconducting region. The boundary region emits electromagnetic radiation responsive to an applied voltage from the voltage source to one of the first superconducting region and the second superconducting region. A current flows from the first superconducting region to the second superconducting region, or vice versa, responsive to the applied voltage.
FILED	Tuesday, February 27, 2018
APPL NO	15/906302
ART UNIT	1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/125 (20130101) H01L 39/225 (20130101) Original (OR) Class
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10700270 — PCM switch and method of making the same

US 10700270	Borodulin et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Pavel Borodulin (Baltimore, Maryland); Nabil Abdel-Meguid El-Hinnawy (Columbia, Maryland); Robert Miles Young (Ellicott City, Maryland)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Pavel Borodulin (Baltimore, Maryland); Nabil Abdel-Meguid El-Hinnawy (Columbia, Maryland); Robert Miles Young (Ellicott City, Maryland)
ABSTRACT	One example includes a method for making a switch. The method includes forming an insulating layer over a substrate. The method also includes forming a resistive heating material over the insulating layer. The method also includes depositing a thermally conductive electrically insulating barrier layer over the heating material. The method also includes forming a phase-change material (PCM) component over the barrier layer spaced apart and proximal to the resistive heating material. The method also includes forming a quench layer proximal to at least one of the resistive heating material and the PCM component. The method further includes forming conductive lines from ends of the PCM component and control lines from ends of the resistive heating material.
FILED	Tuesday, June 21, 2016
APPL NO	15/188754
ART UNIT	3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Static Stores G11C 13/0004 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/06 (20130101) Original (OR) Class H01L 45/144 (20130101) H01L 45/1206 (20130101) H01L 45/1226 (20130101) H01L 45/1286 (20130101) H01L 45/1666 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49105 (20150115)
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10700375 — Biohybrid fuel cell and method

US 10700375	Ganguli et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	Teledyne Scientific and Imaging, LLC (Thousand Oaks, California)
ASSIGNEE(S)	Teledyne Scientific and Imaging, LLC (Thousand Oaks, California)
INVENTOR(S)	Rahul Ganguli (Oak Park, California); Payam Minoofar (Ventura, California); Pavan Narain Mehrotra (Simi Valley, California); Peter Malati (Hawthorne, California)
ABSTRACT	A biohybrid dual chamber fuel cell and method for producing sustainable electrical power from unprocessed biomass include a microbial fuel cell (MFC) for processing the biomass into a clean fuel, a direct alcohol fuel cell (DAFC) operatively connected to the microbial fuel cell for oxidizing the clean fuel to generate electrical power and a separation barrier in the form of a reverse osmosis membrane disposed intermediate the MFC and the DAFC which prevents the diffusion of impurities from the MFC into the DAFC and the return flow of oxidation by-products from the DAFC into the MFC.
FILED	Friday, August 05, 2016
APPL NO	15/229852
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/16 (20130101) Original (OR) Class H01M 8/0631 (20130101) H01M 8/1011 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/522 (20130101) Y02E 60/523 (20130101) Y02E 60/527 (20130101)
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10700378 — Slurry formulation for the formation of layers for solid state batteries

US 10700378	Sakamoto et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	Jeffrey Sakamoto (Ann Arbor, Michigan); Travis Thompson (Ann Arbor, Michigan); Isabel N. Boona (Worthington, Ohio)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan); Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S)	Jeffrey Sakamoto (Ann Arbor, Michigan); Travis Thompson (Ann Arbor, Michigan); Isabel N. Boona (Worthington, Ohio)
ABSTRACT	Disclosed are electrochemical devices, such as lithium ion battery electrodes, lithium ion conducting solid-state electrolytes, and solid-state lithium ion batteries including these electrodes and solid-state electrolytes. Also disclosed are methods for making such electrochemical devices.
FILED	Monday, December 19, 2016
APPL NO	15/383286
ART UNIT	1715 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 1/26 (20130101) B05D 1/30 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/139 (20130101) H01M 4/0402 (20130101) H01M 4/0404 (20130101) H01M 4/0471 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 10/0585 (20130101) H01M 2004/028 (20130101) H01M 2300/0068 (20130101) H01M 2300/0071 (20130101) H01M 2300/0091 (20130101)
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10700382 — Chelating ionic liquids for magnesium battery electrolytes and systems

US 10700382	Buttry et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Daniel A. Buttry (Tempe, Arizona); Tylan S. Watkins (Tempe, Arizona); Joseph Rheinhardt (Phoenix, Arizona)
ABSTRACT	Ionic liquids suitable for use in magnesium batteries are disclosed. In an exemplary embodiment, a rechargeable magnesium battery comprises an anode electrode, a cathode electrode, and a chelating ionic liquid solution in contact therewith. The chelating ionic liquid may comprise at least one cation, at least one anion, and at least one soluble, magnesium salt. The magnesium salt may comprise MgX₂, wherein X comprises at least one of Cl—, Br—, I—, TFSI—, FSI—, ClO₄—, BF₄—, PF₆—, RSO₃— (wherein R consists of at least one of an alkyl or aryl group), RCO₂— (wherein R consists of at least one of an alkyl or aryl group), alkyl borides, alkyl borates, AlCl₄—, AlX_aR_b— (wherein the sum of subscripts a and b is 4, X consists of a halide, and R consists of at least one of an alkyl or aryl group), carboranes, or hexamethyldisilazide.
FILED	Tuesday, November 06, 2018
APPL NO	16/181937
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/054 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2300/0022 (20130101) H01M 2300/0045 (20130101)
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10700386 — Electrically restorable rechargeable battery, and methods of manufacture and methods of operating the battery

US 10700386	Ofer et al.
FUNDED BY	Department of Defense (DOD) Defense Logistics Agency (DLA) Department of the Army (DOA) U.S. Army Tank-Automotive and Armaments Command (TACOM) Missile Defense Agency (MDA)
APPLICANT(S)	CAMX Power LLC (Lexington, Massachusetts)
ASSIGNEE(S)	CAMX POWER LLC (Lexington, Massachusetts)
INVENTOR(S)	David Ofer (Needham, Massachusetts); Suresh Sriramulu (Arlington, Massachusetts)
ABSTRACT	A battery system including: a lithium-ion cell including a positive electrode including a first metal oxide, an electrolyte, and a negative electrode including a second metal oxide having an electrochemical redox potential of 0.5 volt to 3 volts versus lithium; and an electrical circuit including a switchable component connecting the positive electrode and the negative electrode, wherein the switchable component provides a shunt between the positive electrode and the negative electrode in a first switch position, and wherein the electrical circuit is configured to provide a voltage of 0.1 volt or less between the positive electrode and the negative electrode when the switchable component is in the first switch position.
FILED	Wednesday, October 25, 2017
APPL NO	15/793675
ART UNIT	1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/18 (20130101) H01M 2/1673 (20130101) H01M 4/26 (20130101) H01M 4/32 (20130101) H01M 4/0435 (20130101) H01M 4/485 (20130101) H01M 4/525 (20130101) H01M 4/661 (20130101) H01M 10/42 (20130101) H01M 10/44 (20130101) H01M 10/286 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/021 (20130101) H01M 2004/027 (20130101) H01M 2220/20 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/122 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/7011 (20130101)
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10700492 — Integrated pound-drever-hall laser stabilization system

US 10700492	Idjadi et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Direct On-Chip Digital Optical Synthesizer Program (DODOS)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Mohamad Hossein Idjadi (Philadelphia, Pennsylvania); Firooz Aflatouni (Penn Valley, Pennsylvania)
ABSTRACT	A laser frequency control apparatus comprising: (a) a laser; (b) an oscillator configured to receive an output of the laser and to output a modulated signal; (c) a frequency reference configured to receive the modulated signal and to provide an output signal; and (d) a mixer configured to mix at least a portion of the output signal with an output of the oscillator to generate a mixer output, wherein the mixer output is injected to a section of the laser.
FILED	Friday, January 04, 2019
APPL NO	16/239653
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/00 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/021 (20130101) H01S 5/0085 (20130101) H01S 5/0262 (20130101) H01S 5/0265 (20130101) H01S 5/0617 (20130101) H01S 5/0683 (20130101) H01S 5/0687 (20130101) Original (OR) Class H01S 5/02248 (20130101) H01S 5/06817 (20130101)
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10700640 — Harmonic-based nonlinearity factorization scheme to facilitate up-conversion mixer linearity

US 10700640	Li et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Jinbo Li (Davis, California); Qun Gu (Davis, California)
ABSTRACT	The disclosed embodiments relate to the design of a system that implements an up-conversion mixer. This system includes a regulator-based linearized transconductance (g_m) stage, which converts a differential intermediate frequency (IF) voltage signal into a corresponding pair of IF currents. It also includes a pair of current mirrors, which duplicates the pair of IF currents into sources of a set of switching transistors. The set of switching transistors uses a differential local oscillator (LO) signal to gate the duplicated pair of IF currents to produce a differential radio frequency (RF) output signal. Finally, a combination of capacitors and/or inductors is coupled to common source nodes of the set of switching transistors to suppress higher order harmonics in an associated common source node voltage signal.
FILED	Wednesday, June 05, 2019
APPL NO	16/432668
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Electric Digital Data Processing G06F 30/30 (20200101) Demodulation or Transference of Modulation From One Carrier to Another H03D 7/125 (20130101) Original (OR) Class H03D 2200/0033 (20130101) H03D 2200/0088 (20130101) Amplifiers H03F 3/45192 (20130101) H03F 2200/129 (20130101) H03F 2200/451 (20130101) H03F 2203/45116 (20130101) Transmission H04B 1/0475 (20130101) H04B 2001/0433 (20130101) H04B 2001/0491 (20130101)
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10700800 — Estimating frequency-offsets and multi-antenna channels in MIMO OFDM systems

US 10700800	Giannakis et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Georgios B. Giannakis (Minnetonka, Minnesota); Xiaoli Ma (Auburn, Alabama)
ABSTRACT	Techniques are described for carrier frequency offset (CFO) and channel estimation of orthogonal frequency division multiplexing (OFDM) transmissions over multiple-input multiple-output (MIMO) frequency-selective fading channels. A wireless transmitter forms blocks of symbols by inserting training symbols within two or more blocks of information-bearing symbols. The transmitter applies a hopping code to each of the blocks of symbols to insert a null subcarrier at a different position within each of the blocks of symbols, and a modulator outputs a wireless signal in accordance with the blocks of symbols. A receiver receives the wireless signal and estimates the CFO, and outputs a stream of estimated symbols based on the estimated CFO.
FILED	Tuesday, May 24, 2016
APPL NO	15/162978
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 7/046 (20130101) H04B 7/063 (20130101) H04B 7/066 (20130101) H04B 7/0413 (20130101) Multiplex Communication H04J 11/0063 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0016 (20130101) H04L 25/0202 (20130101) H04L 25/0206 (20130101) H04L 25/0228 (20130101) H04L 25/0242 (20130101) H04L 27/2607 (20130101) H04L 27/2613 (20130101) H04L 27/2626 (20130101) H04L 27/2657 (20130101) H04L 27/2671 (20130101) H04L 27/2672 (20130101) H04L 27/2675 (20130101) H04L 27/2692 (20130101) H04L 27/2695 (20130101)
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10701296 — Thermal camera with image enhancement derived from microelectromechanical sensor

US 10701296	Dock et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	RPX Technologies, Inc. (Stillwater, Oklahoma)
ASSIGNEE(S)	RPX Technologies, Inc. (Stillwater, Oklahoma)
INVENTOR(S)	Matthew Dock (Stillwater, Oklahoma); Michael Fox (Stillwater, Oklahoma); Jon Stewart (Stillwater, Oklahoma)
ABSTRACT	A camera system and methods of enhancing images using direct measurement of angular displacement are disclosed. The camera system includes an optical element, a focal plane array (FPA), a motion sensor and a processor. The FPA has pixels sensing image pixel data from the optical element. The pixels have an angular resolution dependent upon a configuration of the optical element and a dimension of the pixels. The pixels detect electromagnetic waves having a wavelength within a range from 800 nanometers to 20 micrometers. The motion sensor senses angular displacement in 3D. The processor receives the image pixel data generated at distinct first instants of time during an image capture period from the FPA and motion reading(s) during the image capture period, converts the motion readings into angular displacement of the FPA, and selects an image processing algorithm to generate at least one image enhancement for the image pixel data.
FILED	Thursday, October 18, 2018
APPL NO	16/164528
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/10 (20130101) G01J 5/0853 (20130101) G01J 5/0862 (20130101) G01J 2005/0077 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) H04N 5/3656 (20130101) Original (OR) Class
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10701353 — Pattern, method, and apparatus for testing imaging system performance

US 10701353	Preece
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	United States of America, as represented by the Secretary of the Army (Fort Belvoir, Virginia)
ASSIGNEE(S)	UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia)
INVENTOR(S)	Bradley L. Preece (Lorton, Virginia)
ABSTRACT	A system is disclosed, comprising a data processing device configured to receive an image of a pattern from an imaging system, calculate a bit sequence based on the pattern, and compare the bit sequence to a true bit sequence to generate an evaluation of the imaging system; and an output device configured to output the evaluation. An exemplary pattern comprises a first plurality of shapes having a first spectral characteristic and a second plurality of shapes having a second spectral characteristic, the plurality of first shapes and the plurality of second shapes being arranged in a pattern that is self-similar at different scales.
FILED	Wednesday, November 27, 2019
APPL NO	16/697237
ART UNIT	2422 — Cable and Television
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00 (20130101) Image Data Processing or Generation, in General G06T 7/80 (20170101) G06T 2207/30168 (20130101) Telephonic Communication H04M 1/0202 (20130101) Pictorial Communication, e.g Television H04N 17/002 (20130101) Original (OR) Class
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10701792 — High power ion beam generator systems and methods

US 10701792	Kobernik et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Department of Energy (DOE)
APPLICANT(S)	PHOENIX LLC (Monona, Wisconsin)
ASSIGNEE(S)	PHOENIX LLC (Monona, Wisconsin)
INVENTOR(S)	Arne Kobernik (Monona, Wisconsin); Carl Sherven (Monona, Wisconsin); Casey Lamers (Monona, Wisconsin); Chris Seyfert (Monona, Wisconsin); Evan Sengbusch (Monona, Wisconsin); Gabriel Becerra (Monona, Wisconsin); Jin Lee (Monona, Wisconsin); Logan Campbell (Monona, Wisconsin); Mark Thomas (Monona, Wisconsin); Michael Taylor (Monona, Wisconsin); Preston Barrows (Monona, Wisconsin); Ross Radel (Monona, Wisconsin); Tye Gribb (Monona, Wisconsin)
ABSTRACT	Provided herein are high energy ion beam generator systems and methods that provide low cost, high performance, robust, consistent, uniform, low gas consumption and high current/high-moderate voltage generation of neutrons and protons. Such systems and methods find use for the commercial-scale generation of neutrons and protons for a wide variety of research, medical, security, and industrial processes.
FILED	Tuesday, November 20, 2018
APPL NO	16/196766
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 37/08 (20130101) H01J 37/32082 (20130101) H01J 41/04 (20130101) H01J 41/14 (20130101) Spark Gaps; Overvoltage Arresters Using Spark Gaps; Sparking Plugs; Corona Devices; Generating Ions to be Introduced into Non-enclosed Gases H01T 23/00 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 31/26 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/46 (20130101) H05H 1/54 (20130101) H05H 3/06 (20130101) H05H 5/04 (20130101) H05H 6/00 (20130101) H05H 7/22 (20130101) Original (OR) Class H05H 9/02 (20130101) H05H 2001/4622 (20130101)
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10701832 — Two-phase liquid cooled electronics

US 10701832	Chainer et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Timothy Joseph Chainer (Putnam Valley, New York); Pritish Ranjan Parida (Stamford, Connecticut); Mark Delorman Schultz (Ossining, New York)
ABSTRACT	Techniques that facilitate two-phase liquid cooling electronics are provided. In one example, a server system comprises a two-phase cooling system and an air moving system. The two-phase cooling system reduces a first temperature of a first electronic component in the server system using a pump that circulates a coolant refrigerant through a two-phase refrigerant loop associated with the first electronic component, where first electronic component satisfies a first defined criterion. The air moving system reduces a second temperature of a second electronic component in the server system using one or more fans associated with the second electronic component, where the second electronic component satisfies a second defined criterion.
FILED	Thursday, March 07, 2019
APPL NO	16/295744
ART UNIT	2835 — Electrical Circuits and Systems
CURRENT CPC	Electric Digital Data Processing G06F 1/20 (20130101) G06F 1/206 (20130101) G06F 1/3206 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101) H01L 23/467 (20130101) H01L 23/473 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/208 (20130101) H05K 7/20136 (20130101) H05K 7/20145 (20130101) H05K 7/20209 (20130101) H05K 7/20309 (20130101) H05K 7/20318 (20130101) H05K 7/20327 (20130101) H05K 7/20381 (20130101) Original (OR) Class H05K 7/20509 (20130101) H05K 7/20727 (20130101) H05K 7/20809 (20130101) H05K 7/20836 (20130101)
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Department of Energy (DOE)

10695741 — System and process for continuous and controlled production of metal-organic frameworks and metal-organic framework composites

US 10695741	Motkuri et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Radha Kishan Motkuri (Richland, Washington); Jagannadha R. Bontha (Richland, Washington); B. Peter McGrail (Pasco, Washington)
ABSTRACT	A MOF production system and method of making are detailed for continuous and controlled synthesis of MOFs and MOF composites. The system can provide optimized yields of MOFs and MOF composites greater than or equal to 95%.
FILED	Friday, June 17, 2016
APPL NO	15/186004
ART UNIT	1764 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/06 (20130101) B01J 19/10 (20130101) Original (OR) Class B01J 19/0013 (20130101) B01J 20/226 (20130101) B01J 20/3085 (20130101) B01J 20/3204 (20130101) B01J 20/3236 (20130101) B01J 20/3293 (20130101) B01J 31/1691 (20130101) B01J 35/026 (20130101) B01J 37/0072 (20130101) B01J 2219/00051 (20130101) B01J 2219/0877 (20130101) B01J 2231/005 (20130101) B01J 2531/16 (20130101) B01J 2531/845 (20130101) B01J 2531/847 (20130101) Acyclic or Carbocyclic Compounds C07C 51/43 (20130101) C07C 51/43 (20130101) C07C 51/43 (20130101) C07C 51/418 (20130101) C07C 51/418 (20130101) C07C 51/418 (20130101) C07C 63/307 (20130101) C07C 63/307 (20130101) C07C 63/307 (20130101) C07C 65/05 (20130101) C07C 65/05 (20130101) C07C 65/05 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 3/003 (20130101) C07F 7/003 (20130101) C07F 15/045 (20130101) C07F 15/065 (20130101)
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10695745 — Solid, hydrophobic aggregators and methods of making and using the same

US 10695745	Shin et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
INVENTOR(S)	Yongsoon Shin (Richland, Washington); George T. Bonheyo (Sequim, Washington); Eric M. Winder (Sequim, Washington)
ABSTRACT	Disclosed herein are aggregators that can be cellulosic particles having high oil sorption capacity, high hydrophobicity, high buoyancy in water, and an aggregation quality that can support environmental remediation of hydrocarbon spills (e.g., crude oil spills) by various cleanup strategies including burning, skimming, or bioremediation. Also disclosed are methods of making the materials and methods of using the materials for environmental remediation.
FILED	Monday, April 09, 2018
APPL NO	15/948888
ART UNIT	1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/02 (20130101) A62D 2101/20 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/24 (20130101) Original (OR) Class B01J 20/2803 (20130101) B01J 20/3206 (20130101) B01J 20/3217 (20130101) B01J 20/3246 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/286 (20130101) C02F 3/348 (20130101) C02F 2101/32 (20130101) C02F 2103/007 (20130101) Polysaccharides; Derivatives Thereof C08B 3/16 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 3/32 (20130101) Hydraulic Engineering E02B 15/041 (20130101) E02B 15/042 (20130101)
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10695811 — Functionally graded coatings and claddings

US 10695811	Joshi et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Vineet V. Joshi (Richland, Washington); Glenn J. Grant (Benton City, Washington); Curt A. Lavender (Richland, Washington); Scott A. Whalen (West Richland, Washington); Saumyadeep Jana (Kennewick, Washington); David Catalini (Hyattsville, Maryland); Jens T. Darsell (West Richland, Washington)
ABSTRACT	A shear assisted extrusion process for producing cladded materials wherein a cladding material and a material to be cladded are placed in sequence with the cladded material positioned to contact a rotating scroll face first and the material to be cladded second. The two materials are fed through a shear assisted extrusion device at a preselected feed rate and impacted by a rotating scroll face to generate a cladded extrusion product. This process allows for increased through wall strength and decreases the brittleness in formed structures as compared to the prior art.
FILED	Saturday, February 17, 2018
APPL NO	15/898515
ART UNIT	3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/002 (20130101) Original (OR) Class B21C 23/04 (20130101) B21C 23/22 (20130101) B21C 23/217 (20130101) B21C 23/218 (20130101) B21C 25/02 (20130101) B21C 27/02 (20130101) B21C 29/003 (20130101)
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10696363 — Floating membrane reservoir system

US 10696363	Hadjerioua
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Boualem Hadjerioua (Knoxville, Tennessee)
ABSTRACT	An improved system and method of storing water for a closed-loop pumped storage hydroelectric system is provided. The method includes providing a floating reservoir, positioning the floating reservoir in a waterbody, loading the floating reservoir with a volume of water from a source other than the surrounding waterbody, and transferring water from within the floating reservoir to an upper or lower reservoir of a pumped storage hydroelectric system. The floating reservoir includes a flexible membrane defining one or more reservoir cells including a vertically collapsible sidewall, such that each reservoir cell defines a depth varying in proportion to its internal volume of water. Each reservoir cell is buoyed by pontoons adjacent an outer periphery of the reservoir cell and is anchored to the shore or streambed.
FILED	Tuesday, February 12, 2019
APPL NO	16/273423
ART UNIT	3678 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Ships or Other Waterborne Vessels; Equipment for Shipping B63B 35/00 (20130101) B63B 35/285 (20130101) Original (OR) Class B63B 2735/00 (20130101) Hydraulic Engineering E02B 9/00 (20130101) Machines or Engines for Liquids F03B 13/06 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/40 (20130101) F05B 2240/93 (20130101) F05B 2250/02 (20130101) F05B 2250/23 (20130101)
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10696451 — Solar panel field array support system and apparatus and method for construction use

US 10696451	Britcher et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Office of Science (DOE-SC)
APPLICANT(S)	Eric Bramwell Britcher (San Jose, California); Jeffrey Allen Moore (San Jose, California); John Andrew Samuels (San Francisco, California)
ASSIGNEE(S)
INVENTOR(S)	Eric Bramwell Britcher (San Jose, California); Jeffrey Allen Moore (San Jose, California); John Andrew Samuels (San Francisco, California)
ABSTRACT	A combined PV panel assembly jig and forklift transport pallet is used to assemble PV panels for transport to a field array from a protected manufacturing environment. The panels are assembled to have adhesively applied rails for transport by a robotic drone on a ground-support rack and are pre-wired. The PV panel assembly jig holds, protects, and aligns the PV panels in an upside down position, opposite to their operational position, for ease of wiring in order to decrease the manual labor required in the field. Once the pallet is transported to the load station at the end of a row of solar panel racks in the field array, a robotic loader lifts the upside down PV panels from the combined PV panel assembly jig and forklift transport pallet in an arcing overhead motion that lifts, tilts, and deposits the PV panels in an upright position at the loading station of a railed rack support as ground-mounted in a solar panel field array.
FILED	Thursday, March 30, 2017
APPL NO	15/475095
ART UNIT	3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 19/44 (20130101) Original (OR) Class Solar Heat Collectors; Solar Heat Systems F24S 2025/014 (20180501) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/6734 (20130101) H01L 31/02 (20130101) H01L 31/18 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/10 (20141201) Technical Subjects Covered by Former US Classification Y10T 29/49117 (20150115)
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10696571 — Multiple pulse charge transfer for capacitive deionization of a fluid

US 10696571	Stadermann et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Michael Stadermann (Pleasanton, California); Steven L. Hunter (Livermore, California)
ABSTRACT	The present disclosure relates to a capacitive deionization system which makes use of a controller, a first capacitor acting as a first electrode, a second capacitor acting as a second electrode, and a first inductor for storing energy received from the first capacitor, and transferring the stored energy to the second capacitor. A first plurality of electronic switches are controlled by the controller to control communication between the first inductor and the first capacitor, and between the first inductor and the second capacitor. An additional energy transfer subsystem is included which has a second inductor for receiving energy from the first capacitor while the first inductor is transferring stored energy to the second capacitor.
FILED	Thursday, October 20, 2016
APPL NO	15/299021
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/4691 (20130101) Original (OR) Class C02F 2201/4612 (20130101)
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10696606 — Zeolitic catalytic conversion of alcohols to hydrocarbon fractions with reduced gaseous hydrocarbon content

US 10696606	Narula et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Chaitanya K. Narula (Knoxville, Tennessee); Brian H. Davison (Knoxville, Tennessee); Zhenglong Li (Knoxville, Tennessee)
ABSTRACT	A method for converting an alcohol to a hydrocarbon fraction reduced in gaseous hydrocarbon content, the method comprising: (i) contacting said alcohol with a metal-loaded zeolite catalyst under conditions suitable for converting said alcohol to a first hydrocarbon fraction containing liquid hydrocarbons having at least five carbon atoms along with gaseous hydrocarbons having less than five carbon atoms, wherein said metal-loaded zeolite catalyst is catalytically active for converting said alcohol to said first hydrocarbon fraction; and (ii) selectively removing said gaseous hydrocarbons from the first hydrocarbon fraction and contacting said gaseous hydrocarbons with a metal-loaded zeolite catalyst under conditions suitable for converting said gaseous hydrocarbons into liquid hydrocarbons having at least five carbon atoms to produce a second hydrocarbon fraction reduced in gaseous hydrocarbon content, wherein the metal-loaded zeolite catalyst in steps (i) and (ii) are the same or different.
FILED	Thursday, June 09, 2016
APPL NO	15/178046
ART UNIT	1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 1/20 (20130101) Original (OR) Class C07C 1/24 (20130101) C07C 1/24 (20130101) C07C 2/12 (20130101) C07C 2/58 (20130101) C07C 11/04 (20130101) C07C 2529/40 (20130101) C07C 2529/48 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 3/45 (20130101) C10G 3/49 (20130101) C10G 50/00 (20130101) C10G 2300/1014 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/04 (20130101) C10L 1/06 (20130101) C10L 1/08 (20130101) C10L 2200/043 (20130101) C10L 2200/0423 (20130101) C10L 2200/0446 (20130101) C10L 2200/0469 (20130101) C10L 2270/04 (20130101) C10L 2270/023 (20130101) C10L 2270/026 (20130101) C10L 2290/26 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/52 (20151101)
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10696614 — Photocatalytic reduction of carbon dioxide to methanol or carbon monoxide using cuprous oxide

US 10696614	Wu et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	Yimin Wu (Schaumburg, Illinois); Tijana Rajh (Naperville, Illinois); Ian McNulty (Romeoville, Illinois); Yuzi Liu (Woodridge, Illinois)
ABSTRACT	Provided herein are methods of CO₂reduction to methanol or CO using a Cu₂O catalyst.
FILED	Friday, December 29, 2017
APPL NO	15/858307
ART UNIT	1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/123 (20130101) B01J 19/127 (20130101) B01J 23/72 (20130101) B01J 27/051 (20130101) B01J 35/002 (20130101) B01J 35/004 (20130101) B01J 37/04 (20130101) B01J 37/10 (20130101) B01J 37/031 (20130101) B01J 37/088 (20130101) B01J 2219/0884 (20130101) B01J 2219/0892 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/40 (20170801) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 3/02 (20130101) Acyclic or Carbocyclic Compounds C07C 29/15 (20130101) Original (OR) Class C07C 29/15 (20130101) C07C 31/04 (20130101)
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10696916 — Lubricant compositions comprising core-shell nanoparticles

US 10696916	Aswath et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Pranesh Aswath (Grapevine, Texas); Richard B. Timmons (Arlington, Texas); Vinay Sharma (Arlington, Texas); Ali Erdemir (Naperville, Illinois)
ABSTRACT	Lubricant compositions, core-shell nanoparticles, and related methods are disclosed. In an exemplary embodiment, a lubricant composition includes a plurality of core-shell nanoparticles. The nanoparticles include a core, a first shell disposed on the core, and a second shell disposed on the first shell. The first shell is formed from a siliceous material and the second shell is formed from a hydrophobic material. The first and second shells form functional coatings that reduce wear and friction of parts lubricated with the lubricant composition.
FILED	Friday, May 12, 2017
APPL NO	15/593444
ART UNIT	1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/14 (20130101) B01J 13/22 (20130101) Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 131/04 (20130101) Original (OR) Class C10M 137/10 (20130101) C10M 145/14 (20130101) C10M 155/02 (20130101) C10M 161/00 (20130101) C10M 177/00 (20130101) C10M 2203/1006 (20130101) C10M 2203/1025 (20130101) C10M 2203/1025 (20130101) C10M 2205/0285 (20130101) C10M 2209/084 (20130101) C10M 2213/02 (20130101) C10M 2213/062 (20130101) C10M 2213/062 (20130101) C10M 2223/045 (20130101) C10M 2229/041 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2210/02 (20130101) C10N 2220/022 (20130101) C10N 2220/082 (20130101) C10N 2230/06 (20130101) C10N 2230/42 (20130101) C10N 2230/56 (20130101) C10N 2240/10 (20130101) C10N 2250/12 (20130101) C10N 2250/16 (20130101) C10N 2260/04 (20130101) C10N 2260/04 (20130101)
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10696954 — Hybrid peroxidases with enhanced activity and stability

US 10696954	Kohler et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California); National Technology and Engineering Solutions of Sandia, LLC (NTESS) (Albuquerque, New Mexico)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Amanda C. Kohler (Albany, California); Kenneth L. Sale (Livermore, California); Blake A. Simmons (San Francisco, California)
ABSTRACT	Described herein are stable hybrid peroxidases capable of oxidizing manganese and high-reduction potential substrates, methods of generating such peroxidases, and method of using the peroxidases in reactions that are less environmentally toxic.
FILED	Monday, December 10, 2018
APPL NO	16/215479
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0065 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) Enzymes C12Y 111/01007 (20130101)
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10696977 — Carbon fixation systems in plants and algae

US 10696977	Sayre et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E) Office of Science (DOE-SC) Basic Energy Sciences (BES) Energy Frontier Research Centers (EFRC) Center for Advanced Biofuel Systems (CABS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Emerging Frontiers (EF)
APPLICANT(S)	NMC, INC. (Los Alamos, New Mexico)
ASSIGNEE(S)	NCM, INC. (Los Alamos, New Mexico)
INVENTOR(S)	Richard Thomas Sayre (Los Alamos, New Mexico); Somya S. Subramanian (Los Alamos, New Mexico); Natalia Friedland (Los Alamos, New Mexico)
ABSTRACT	Provided are methods for elevating cyclic electron transfer activity, improving carbon concentration, and enhancing carbon fixation in C3 and C4 plants, and algae, and producing biomass or other products from C3 or C4 plants, and algae, selected from among, for example, starches, oils, fatty acids, lipids, cellulose or other carbohydrates, alcohols, sugars, nutraceuticals, pharmaceuticals, fragrance and flavoring compounds, and organic acids, as well as transgenic plants produced thereby. These methods and transgenic plants and algae encompass the expression, or overexpression, of various combinations of genes that improve carbon concentrating systems in plants and algae, such as bicarbonate transport proteins, carbonic anhydrase, light driven proton pump, cyclic electron flow regulators, etc.
FILED	Tuesday, March 19, 2019
APPL NO	16/358331
ART UNIT	1663 — Plants
CURRENT CPC	Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 1/00 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101)
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10697706 — Heat exchanger

US 10697706	Hughes et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Modine Manufacturing Company (Racine, Wisconsin)
ASSIGNEE(S)	Modine Manufacturing Company (Racine, Wisconsin)
INVENTOR(S)	Gregory Gerald Hughes (Milwaukee, Wisconsin); Michael J. Reinke (Franklin, Wisconsin); Tony Rousseau (Racine, Wisconsin)
ABSTRACT	A heat exchanger that includes first and second headers, a first flow conduit fluidly connecting the first and second headers to allow for a flow of a first fluid through the heat exchanger, the first flow conduit being bounded by a first generally planar wall section extending between the first and second headers, a second flow conduit to allow for a flow of the second fluid through the heat exchanger, the second flow conduit being bounded by a second generally planar wall section spaced apart from the first generally planar wall section to define a gap therebetween, and a thermally conductive structure arranged within the gap and joined to the first and second generally planar wall sections to transfer heat therebetween. The thermally conductive structure is isolated from the first fluid by the first generally planar wall section and from the second fluid by the second generally planar wall section.
FILED	Tuesday, September 24, 2013
APPL NO	14/430787
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 1/0426 (20130101) Original (OR) Class F28D 7/0025 (20130101) F28D 21/0003 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 3/027 (20130101) F28F 2265/26 (20130101)
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10697918 — Polymer / single-walled carbon nanotube composite for gas detection

US 10697918	Swager et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Timothy Manning Swager (Newton, Massachusetts); Sophie Liu (Annandale, New Jersey); Bora Yoon (Cambridge, Massachusetts)
ABSTRACT	A sensor can include a conductive region in electrical communication with at least two electrodes, the conductive region can include a composite of a polymer and SWCNTs immobilized onto a substrate. In certain embodiment, a linker can be grafted on the substrate. The linker can connect the substrate and the composite of the polymer and SWCNTs. In certain embodiments, the linker can covalently bond the polymer to the substrate. In certain embodiments, metal nanoparticles or ions can be incorporated as a metal sensitizer to confer further selectivity or sensitivity to the device. In certain embodiments, the polymer can act as a ligand for a variety of metal ions. By incorporating a specific metal ion, the sensor can selectively detect a specific analyte. In certain embodiments, the composite of the polymer and SWCNTs can be functionalized. In certain embodiments, the composite can further include a sensing element.
FILED	Thursday, May 04, 2017
APPL NO	15/586466
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/168 (20170801) C01B 2202/02 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/44 (20130101) C08F 8/44 (20130101) C08F 38/02 (20130101) C08F 126/06 (20130101) C08F 126/06 (20130101) Compositions of Macromolecular Compounds C08L 39/04 (20130101) C08L 39/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/126 (20130101) Original (OR) Class G01N 27/127 (20130101) G01N 27/4162 (20130101)
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10697931 — Methods of particle manipulation and analysis

US 10697931	Ault et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	The Trustees of Princeton University (Princeton, New Jersey); University of Hawaii (Honolulu, Hawaii); UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Jesse Ault (Knoxville, Tennessee); Sangwoo Shin (Honolulu, Hawaii); Howard A. Stone (Princeton, New Jersey); Jie Feng (Princeton, New Jersey); Patrick Warren (Wirral, United Kingdom)
ABSTRACT	Methods described herein, in some embodiments, permit extraction of particle structural and/or surface charge data from gradient induced particle motion in channels. In one aspect, a method of manipulating particle motion comprises introducing a fluid into a channel, the fluid comprising particles, and driving particle accumulation to a preselected location in the channel by setting advective velocity of the fluid to offset diffusiophoretic mobility of the particles at the preselected location.
FILED	Wednesday, December 05, 2018
APPL NO	16/210760
ART UNIT	2877 — Optics
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/00 (20130101) G01N 15/1456 (20130101) G01N 27/44721 (20130101) Original (OR) Class G01N 2015/0053 (20130101)
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10697934 — Miniaturized pulsed discharge ionization detector, non-radioactive ionization sources, and methods thereof

US 10697934	Manginell et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Ronald P. Manginell (Albuquerque, New Mexico); Matthew W. Moorman (Albuquerque, New Mexico); Kent B. Pfeifer (Los Lunas, New Mexico)
ABSTRACT	The present application relates to pulsed discharge ionization detectors (PDIDs) and non-radioactive ionization sources, including miniaturized forms thereof. In some examples, the PDID includes annular electrodes, where each electrode is disposed between annular insulators. Also provided herein are methods of making and using such PDIDs, such as for detecting one or more volatile organic compounds, as well as non-radioactive ionization sources.
FILED	Monday, December 17, 2018
APPL NO	16/222138
ART UNIT	2853 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/68 (20130101) G01N 27/70 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/182 (20130101) H05K 1/0306 (20130101) H05K 3/32 (20130101) H05K 3/308 (20130101) H05K 2203/166 (20130101)
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10697938 — Fluid characterization using acoustics

US 10697938	Cattaneo et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico); Chevron U.S.A. Inc. (San Ramon, California)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico); Chevron U.S.A. Inc. (San Ramon, California)
INVENTOR(S)	Alessandro Cattaneo (Los Alamos, New Mexico); Dipen N. Sinha (Los Alamos, New Mexico); Todd Andrew Jankowski (Los Alamos, New Mexico); James Schrodt (San Ramon, California)
ABSTRACT	A measurement system and a method for determining steam quality (i.e. vapor mass fraction) measurements of multiphase fluid flowing through pipes are described. An acoustic sensor device consists of an acoustic transmitter and an acoustic receiver that are designed to be attached to a pipe. The acoustic transmitter and the acoustic receiver are exposed to an interior space of the pipe through openings in a wall of the pipe. Acoustic waves generated by the transmitter and captured by the receiver traverse the multiphase fluid flowing into the pipe. Swept-frequency acoustic interferometry (SFAI) technique is used to measure ultrasonic acoustic properties of a fluid. Machine-learning techniques based on principal component analysis, support vector machine regression and support vector machine classification are used for determining steam quality.
FILED	Thursday, March 15, 2018
APPL NO	16/494663
ART UNIT	2861 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/02 (20130101) G01N 29/28 (20130101) G01N 29/222 (20130101) Original (OR) Class G01N 29/245 (20130101) G01N 29/323 (20130101) G01N 29/326 (20130101) G01N 29/4418 (20130101) G01N 2291/021 (20130101) G01N 2291/048 (20130101) G01N 2291/102 (20130101)
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10698104 — Apparatus, system and method for highlighting activity-induced change in multi-pass synthetic aperture radar imagery

US 10698104	Simonson et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Katherine M. Simonson (Cedar Crest, New Mexico); David Nikolaus Perkins (Cleveland, Ohio)
ABSTRACT	Described herein are various technologies relating to constructing a differenced change product (DCP) image. A plurality of synthetic aperture radar (SAR) images of a scene are generated based upon radar signals directed towards and reflected off of the scene, and a plurality of coherence change detection (CCD) images of the scene are generated based upon the SAR images. The CCD images are registered with one another, and their pixel values re-scaled according to a monotonic mapping function. The DCP image is generated based upon a computed pixel-wise difference between a pair of the re-scaled CCD images. The DCP image identifies locations in the scene where human activity-induced change is likely to have occurred between a pair of SAR passes of the scene.
FILED	Tuesday, March 27, 2018
APPL NO	15/936806
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/904 (20190501) Original (OR) Class G01S 13/9023 (20130101) G01S 13/9029 (20130101) G01S 13/9088 (20190501) Image Data Processing or Generation, in General G06T 5/50 (20130101) G06T 2207/10044 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14831 (20130101)
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10698163 — Polarization diversity optical interface assembly

US 10698163	Mathai et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	Sagi Mathai (Palo Alto, California); Wayne Victor Sorin (Mountain View, California); Marco Fiorentino (Mountain View, California); Michael Renne Ty Tan (Menlo Park, California)
ABSTRACT	Examples herein relate to polarization diversity optical interface assemblies including a single mode optical fiber and first and second grating couplers disposed on a substrate. The first and second grating couplers are coupled to first and second waveguides, respectively. The assemblies further includes an optical connector to couple light between the single mode optical fiber and each of the first and second grating couplers. The optical connector includes a ferrule and a walk-off crystal. The ferrule is coupled to a portion of the single mode optical fiber. The walk-off crystal is configured to spatially separate the light into first and second orthogonal polarization modes prior to passing through the respective first and second grating couplers and/or combine the first and second polarization modes of the light prior to passing through the single mode optical fiber.
FILED	Tuesday, October 30, 2018
APPL NO	16/175578
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/126 (20130101) G02B 6/2733 (20130101) Original (OR) Class G02B 6/2773 (20130101) G02B 2006/12147 (20130101)
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10698692 — Controlling the operating speed of stages of an asynchronous pipeline

US 10698692	Sadowski et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Advanced Micro Devices, Inc. (Sunnyvale, California)
ASSIGNEE(S)	ADVANCED MICRO DEVICES, INC. (Santa Clara, California)
INVENTOR(S)	Greg Sadowski (Boxborough, Massachusetts); John Kalamatianos (Boxborough, Massachusetts); Shomit N. Das (Austin, Texas)
ABSTRACT	An asynchronous pipeline includes a first stage and one or more second stages. A controller provides control signals to the first stage to indicate a modification to an operating speed of the first stage. The modification is determined based on a comparison of a completion status of the first stage to one or more completion statuses of the one or more second stages. In some cases, the controller provides control signals indicating modifications to an operating voltage applied to the first stage and a drive strength of a buffer in the first stage. Modules can be used to determine the completion statuses of the first stage and the one or more second stages based on the monitored output signals generated by the stages, output signals from replica critical paths associated with the stages, or a lookup table that indicates estimated completion times.
FILED	Thursday, July 21, 2016
APPL NO	15/216094
ART UNIT	2123 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 9/3836 (20130101) G06F 9/3869 (20130101) G06F 9/3871 (20130101) Original (OR) Class
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10699820 — Three dimensional radioisotope battery and methods of making the same

US 10699820	Nikolic et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Rebecca J. Nikolic (Oakland, California); Adam P. Conway (Livermore, California); Roger A. Henderson (Livermore, California); Victor P. Karpenko (Livermore, California); Qinghui Shao (Fremont, California); Dawn A. Shaughnessy (Livermore, California); Mark A. Stoyer (Livermore, California); Lars F. Voss (Livermore, California)
ABSTRACT	According to one embodiment, a product includes an array of three dimensional structures, where each of the three dimensional structure includes a semiconductor material; a cavity region between each of the three dimensional structures; and a first material in contact with at least one surface of each of the three dimensional structures, where the first material is configured to provide high energy particle and/or ray emissions.
FILED	Friday, March 14, 2014
APPL NO	14/214244
ART UNIT	2834 — Electrical Circuits and Systems
CURRENT CPC	Obtaining Energy From Radioactive Sources; Applications of Radiation From Radioactive Sources, Not Otherwise Provided For; Utilising Cosmic Radiation G21H 1/00 (20130101) G21H 1/06 (20130101) Original (OR) Class
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10700229 — Multi-layered perovskites, devices, and methods of making the same

US 10700229	Zhu et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado); Shanghai Jiao Tong University (Minhang, China PRC)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S)	Kai Zhu (Littleton, Colorado); Yixin Zhao (Shanghai, China PRC); Mengjin Yang (Dallas, Texas); Taiyang Zhang (Shanghai, China PRC)
ABSTRACT	Methods are described that include contacting an alkyl ammonium metal halide film with an alkyl ammonium halide, where the alkyl ammonium metal halide film includes a first halogen and a metal, the alkyl ammonium halide includes a second halogen, such that the contacting forms an alkyl ammonium metal mixed-halide film that interfaces with the alkyl ammonium metal halide film, where the alkyl ammonium metal mixed-halide film includes the first halogen, the second halogen, and the metal.
FILED	Thursday, November 17, 2016
APPL NO	15/777275
ART UNIT	1622 — Organic Chemistry
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/043 (20130101) B32B 2307/202 (20130101) B32B 2311/14 (20130101) B32B 2311/16 (20130101) B32B 2457/12 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/34 (20130101) C01P 2002/72 (20130101) C01P 2004/03 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/24 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/055 (20130101) Original (OR) Class H01L 31/0256 (20130101) H01L 51/0003 (20130101) H01L 51/0032 (20130101) H01L 51/4226 (20130101) H01L 2031/0344 (20130101)
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10700234 — Fabrication processes for effectively transparent contacts

US 10700234	Saive et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Rebecca Saive (Pasadena, California); Harry A. Atwater (South Pasadena, California); Sisir Yalamanchili (Pasadena, California); Colton Bukowsky (Pasadena, California); Thomas Russell (Pasadena, California)
ABSTRACT	In conventional solar cells with metal contacts, a non-negligible fraction of the incoming solar power is immediately lost either through absorption or reflection upon interaction with the contacts. Effectively transparent contacts (“ETCs”) for solar cells can be referred to as three-dimensional contacts designed to redirect incoming light onto a photoabsorbing surface of a solar cell. In many embodiments, the ETCs have triangular cross-sections. Such ETCs can be placed on a photoabsorbing surface such that at least one of their sides forms an angle with the photoabsorbing surface. In this configuration, the ETCs can redirect incident light onto the photoabsorbing surface, mitigating or eliminating reflection loss compared to conventional solar cells. When constructed in accordance with a number of embodiments of the invention, ETCs can be effectively transparent and highly conductive.
FILED	Friday, August 17, 2018
APPL NO	15/999264
ART UNIT	2812 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1884 (20130101) Original (OR) Class H01L 31/022425 (20130101) H01L 31/022466 (20130101)
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10700361 — Nanofibrous electrocatalyst including nanofibrous continuous network of graphitic nanofibers having embedded catalytically active metal moieties

US 10700361	Liu et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UChicago Argonne, LLC (Chicago, Illinois)
ASSIGNEE(S)	UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	Di-Jia Liu (Elmhurst, Illinois); Jianglan Shui (Darien, Illinois); Chen Chen (Darien, Illinois)
ABSTRACT	A nanofibrous catalyst and method of manufacture. A precursor solution of a transition metal based material is formed into a plurality of interconnected nanofibers by electro-spinning the precursor solution with the nanofibers converted to a catalytically active material by a heat treatment. Selected subsequent treatments can enhance catalytic activity.
FILED	Monday, May 02, 2016
APPL NO	15/144650
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/158 (20170801) C01B 32/166 (20170801) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/1613 (20130101) H01M 4/382 (20130101) H01M 4/926 (20130101) H01M 4/8828 (20130101) H01M 4/9016 (20130101) H01M 4/9041 (20130101) H01M 4/9083 (20130101) Original (OR) Class H01M 8/02 (20130101) H01M 8/0263 (20130101) H01M 8/1004 (20130101) H01M 8/1018 (20130101) H01M 8/1023 (20130101) H01M 8/1039 (20130101) H01M 10/0525 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 10/0585 (20130101) H01M 12/08 (20130101) H01M 2004/027 (20130101) H01M 2004/8684 (20130101) H01M 2004/8689 (20130101) H01M 2008/1095 (20130101) H01M 2300/0028 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/128 (20130101)
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10700372 — Membrane electrode assembly

US 10700372	Haugen et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	3M INNOVATIVE PROPERTIES COMPANY (St. Paul, Minnesota)
ASSIGNEE(S)	3M Innovative Properties Company (St. Paul, Minnesota)
INVENTOR(S)	Gregory M. Haugen (Edina, Minnesota); Ljiljana L. Atanasoska (Oakland, California); Radoslav Atanasoski (Oakland, California); Andrew T. Haug (Woodbury, Minnesota); Dennis F. Van Der Vliet (Lubbock, Texas); Jimmy L. Wong (Oakdale, Minnesota); Andrew M. Armstrong (Stillwater, Minnesota)
ABSTRACT	Membrane electrode assembly comprising oxygen evolution reaction catalyst disposed in gas distribution layer (100, 700) or between gas distribution layer (100, 700 and gas dispersion layer (200, 600). Membrane electrode assemblies described herein are useful, for example, in electrochemical devices such as a fuel cell.
FILED	Wednesday, December 09, 2015
APPL NO	15/531786
ART UNIT	1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/90 (20130101) H01M 4/92 (20130101) H01M 4/8615 (20130101) H01M 8/1004 (20130101) Original (OR) Class
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10700373 — Membrane electrode assembly and method of making the same

US 10700373	Capuano et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	PROTON ENERGY SYSTEMS, INC. (Wallingford, Connecticut)
ASSIGNEE(S)	PROTON ENERGY SYSTEMS, INC. (Wallingford, Connecticut)
INVENTOR(S)	Christopher Bryce Capuano (Middletown, Connecticut); Morgan Elizabeth Pertoso (Middletown, Connecticut); Nemanja Danilovic (New Haven, Connecticut)
ABSTRACT	Disclosed herein is a method of manufacturing a membrane electrode assembly (MEA) including directly depositing a liquid suspension containing a platinum precursor onto an ionically conductive membrane (e.g., proton-exchange membrane) that, when the platinum precursor deposit layer is reduced, provides a layer that will scavenge hydrogen that has diffused back through the membrane due to cell stack pressure differential.
FILED	Tuesday, August 22, 2017
APPL NO	15/682803
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 55/001 (20130101) C01G 55/004 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 12/16 (20130101) C08F 14/18 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/226 (20130101) C08G 65/4025 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/881 (20130101) H01M 4/8817 (20130101) H01M 8/1004 (20130101) Original (OR) Class H01M 8/1023 (20130101) H01M 8/1025 (20130101) H01M 8/1027 (20130101) H01M 8/1055 (20130101) H01M 2008/1095 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/56 (20151101)
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10700639 — Subcritical-voltage magnetron RF power source

US 10700639	Kazakevich et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Small Business Administration (SBA) Small Business Technology Transfer (STTR)
APPLICANT(S)	Muons, Inc. (Batavia, Illinois)
ASSIGNEE(S)	Muons, Inc. (Batavia, Illinois)
INVENTOR(S)	Grigory M. Kazakevich (North Aurora, Illinois); Michael L. Neubauer (San Francisco, California); Valeri A. Lebedev (Wheaton, Illinois); Vyacheslav P. Yakovlev (Batavia, Illinois)
ABSTRACT	A system and method of operating a magnetron power source can achieve a broad range of output power control by operating a magnetron with its cathode voltage lower than that needed for free running oscillations (e.g., below the Kapitsa critical voltage or equivalently below the Hartree voltage) A sufficiently strong injection-locking signal enables the output power to be coherently generated and to be controlled over a broad power range by small changes in the cathode voltage. In one embodiment, the present system and method is used for a practical, single, frequency-locked 2-magnetron system design.
FILED	Friday, August 02, 2019
APPL NO	16/530646
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 9/10 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/02 (20130101) H05H 2007/025 (20130101)
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10700779 — System and method for compact adaptive free space optical communications

US 10700779	Panas
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Robert Matthew Panas (Dublin, California)
ABSTRACT	The present disclosure relates to a free-space optical communications system that may make use of a controller and a digital micro mirror (DMM) assembly in communication with the controller. The DMM may have a plurality of independently controllable micromirror elements forming both an emitter and a receiver. A laser is included which is configured to generate an optical beam which may be applied to select ones of the first subpluralities of micromirror elements to generate a transmitted free space optical signal along a selected vector. A detector is included for receiving an incoming free space optical signal imaged by at least one of the micromirror elements.
FILED	Tuesday, April 16, 2019
APPL NO	16/385618
ART UNIT	2636 — Optical Communications
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 26/10 (20130101) G02B 26/0833 (20130101) Transmission H04B 10/11 (20130101) Original (OR) Class H04B 10/66 (20130101) H04B 10/503 (20130101)
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10700872 — System for authenticating an additively manufactured object

US 10700872	Hamlet et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Jason Hamlet (Albuquerque, New Mexico); Todd Bauer (Albuquerque, New Mexico)
ABSTRACT	A method for authenticating an additively manufactured (AM) object is disclosed herein. A computing device obtains a measurement that is indicative of a stochastic distribution of dopant incorporated into the AM object. The computing device generates authentication data for the AM object based upon the measurement, and authenticates the AM object based upon the authentication data.
FILED	Tuesday, December 12, 2017
APPL NO	15/838856
ART UNIT	2435 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0866 (20130101) H04L 9/3247 (20130101) Original (OR) Class
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10701767 — Induction heating cells with controllable thermal expansion of bladders and methods of using thereof

US 10701767	Matsen et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Marc R. Matsen (Seattle, Washington); Lee C. Firth (Renton, Washington); Mark A. Negley (Kirkland, Washington)
ABSTRACT	Disclosed herein are induction heating cells and methods of using these cells for processing. An induction heating cell may be used for processing (e.g., consolidating and/or curing a composite layup having a non-planar portion. The induction heating cell comprises a caul, configured to position over and conform to this non-planar portion. Furthermore, the cell comprises a mandrel, configured to position over the caul and force the caul again the surface of the feature. The CTE of the caul may be closer to the CTE of the composite layup than to the CTE of the mandrel. As such, the caul isolates the composite layup from the dimensional changes of the mandrel, driven by temperature fluctuations. At the same time, the caul may conform to the surface of the mandrel, which can be used to define the shape and transfer pressure to the non-planar portion.
FILED	Thursday, December 14, 2017
APPL NO	15/841964
ART UNIT	3754 — Fluid Handling and Dispensing
CURRENT CPC	Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/06 (20130101) H05B 6/10 (20130101) Original (OR) Class H05B 6/105 (20130101)
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10701792 — High power ion beam generator systems and methods

US 10701792	Kobernik et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Department of Energy (DOE)
APPLICANT(S)	PHOENIX LLC (Monona, Wisconsin)
ASSIGNEE(S)	PHOENIX LLC (Monona, Wisconsin)
INVENTOR(S)	Arne Kobernik (Monona, Wisconsin); Carl Sherven (Monona, Wisconsin); Casey Lamers (Monona, Wisconsin); Chris Seyfert (Monona, Wisconsin); Evan Sengbusch (Monona, Wisconsin); Gabriel Becerra (Monona, Wisconsin); Jin Lee (Monona, Wisconsin); Logan Campbell (Monona, Wisconsin); Mark Thomas (Monona, Wisconsin); Michael Taylor (Monona, Wisconsin); Preston Barrows (Monona, Wisconsin); Ross Radel (Monona, Wisconsin); Tye Gribb (Monona, Wisconsin)
ABSTRACT	Provided herein are high energy ion beam generator systems and methods that provide low cost, high performance, robust, consistent, uniform, low gas consumption and high current/high-moderate voltage generation of neutrons and protons. Such systems and methods find use for the commercial-scale generation of neutrons and protons for a wide variety of research, medical, security, and industrial processes.
FILED	Tuesday, November 20, 2018
APPL NO	16/196766
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 37/08 (20130101) H01J 37/32082 (20130101) H01J 41/04 (20130101) H01J 41/14 (20130101) Spark Gaps; Overvoltage Arresters Using Spark Gaps; Sparking Plugs; Corona Devices; Generating Ions to be Introduced into Non-enclosed Gases H01T 23/00 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 31/26 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/46 (20130101) H05H 1/54 (20130101) H05H 3/06 (20130101) H05H 5/04 (20130101) H05H 6/00 (20130101) H05H 7/22 (20130101) Original (OR) Class H05H 9/02 (20130101) H05H 2001/4622 (20130101)
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National Science Foundation (NSF)

10694972 — Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment

US 10694972	Davalos et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia)
ASSIGNEE(S)	Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia)
INVENTOR(S)	Rafael V. Davalos (Blacksburg, Virginia); Mohammad Bonakdar (Blacksburg, Virginia); Eduardo L. Latouche (Blacksburg, Virginia); Roop L. Mahajan (Blacksburg, Virginia); John L. Robertson (Blacksburg, Virginia); Christopher B. Arena (Blacksburg, Virginia); Michael B. Sano (Blacksburg, Virginia)
ABSTRACT	Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy. Provided herein are embodiments of an electrical conductivity sensor having an impedance sensor, where the impedance sensor can be configured to measure a low-frequency and a high-frequency impedance and a substrate, where the impedance sensor is coupled to the substrate. The substrate can be flexible. In embodiments, the impedance sensor can contain two or more electrical conductors. The electrical conductors can be in a bipolar configuration. The electrical conductors can be in a tetrapolar configuration. In embodiments, the electrical conductivity sensor can have two impedance sensors that can be coupled to the substrate such that they are orthogonal to each other.
FILED	Tuesday, December 15, 2015
APPL NO	15/536333
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/0538 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5438 (20130101)
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10694996 — Instrumented physiotherapeutic, ambulatory, and mobility vest to monitor and provide feedback to patients and caregivers

US 10694996	Williamson et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Abililife, Inc. (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	Abililife, Inc. (Pittsburgh, Pennsylvania)
INVENTOR(S)	Courtney Denise Williamson (Pittsburgh, Pennsylvania); Britta Kathleen Ulm (Pittsburgh, Pennsylvania); Noah Peter Papas (Pittsburgh, Pennsylvania)
ABSTRACT	Improved methods and systems are disclosed for a physiotherapeutic device having a waist tensioning system and a spine support system that may enable correction and/or maintaining of postural stance for individuals suffering from poor posture and/or neurodegenerative disease. The physiotherapeutic device includes a tensioner mechanism. Waist straps attached to the lumbar expansion portion may be configured to be routed through the anchor and wrapped around the vest when the user wears the device. The device also includes shoulder straps, each having a first end attached to a top, rear portion of the vest and a second end attached to the central member. The physiotherapeutic device may be outfitted with sensors to detect statuses and symptoms relevant to the patient and caregiver and to provide reporting and feedback to both the patient and caregiver.
FILED	Wednesday, December 13, 2017
APPL NO	15/840675
ART UNIT	3786 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/165 (20130101) A61B 5/0295 (20130101) A61B 5/486 (20130101) A61B 5/746 (20130101) A61B 5/747 (20130101) A61B 5/0816 (20130101) A61B 5/1116 (20130101) A61B 5/1117 (20130101) A61B 5/1118 (20130101) A61B 5/02055 (20130101) A61B 5/02438 (20130101) A61B 5/4082 (20130101) A61B 5/4833 (20130101) A61B 5/4836 (20130101) A61B 5/6805 (20130101) Original (OR) Class A61B 5/7282 (20130101) A61B 7/04 (20130101) A61B 2560/0475 (20130101) A61B 2562/0219 (20130101) A61B 2562/0223 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/026 (20130101) A61F 5/028 (20130101)
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10695288 — Reactive oxygen species (ROS)-responsive compositions and methods thereof

US 10695288	Duvall et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE)
APPLICANT(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Craig L. Duvall (Nashville, Tennessee); John R. Martin (Nashville, Tennessee); Kristin P. O'Grady (Nashville, Tennessee); Christopher E. Nelson (Nashville, Tennessee)
ABSTRACT	A reactive oxygen species savaging emulsion; the emulsion comprising an injectable pharmaceutically acceptable composition and a polymeric poly(propylene sulfide) microsphere for targeted delivery to a site with elevated reactive oxygen species. In embodiments of the present invention, the microsphere is loaded with a biologically active agent.
FILED	Thursday, November 19, 2015
APPL NO	14/946732
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Original (OR) Class A61K 9/107 (20130101) A61K 9/1641 (20130101) A61K 31/121 (20130101) A61K 31/4468 (20130101)
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10695562 — Interventional drug delivery system and associated methods

US 10695562	DeSimone et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S)	Joseph DeSimone (Chapel Hill, North Carolina); Mary Napier (Carrboro, North Carolina); Jonathan Pillai (Chapel Hill, North Carolina); James Byrne (Chapel Hill, North Carolina); Lukas Miller Roush (Chapel Hill, North Carolina); Jen Jen Yeh (Chapel Hill, North Carolina); Matt Parrott (Carrboro, North Carolina)
ABSTRACT	A delivery system for local drug delivery to a target site of internal body tissue is provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A reservoir is configured to be disposed such that the reservoir is capable of interacting with the localized electric field. The reservoir is configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field. Associated methods are also provided.
FILED	Wednesday, June 24, 2015
APPL NO	14/748361
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/1492 (20130101) A61B 2018/00214 (20130101) A61B 2018/00898 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0002 (20130101) A61K 9/0009 (20130101) A61K 9/0024 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/16 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/00 (20130101) A61N 1/05 (20130101) A61N 1/30 (20130101) A61N 1/044 (20130101) A61N 1/303 (20130101) A61N 1/306 (20130101) Original (OR) Class A61N 1/325 (20130101) A61N 1/327 (20130101) A61N 1/0428 (20130101) A61N 1/0444 (20130101) A61N 1/0448 (20130101) A61N 1/0507 (20130101) A61N 1/36002 (20170801)
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10696034 — Systems, devices, and methods for deposition-based three-dimensional printing

US 10696034	Pattinson et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Social, Behavioral and Economic Sciences (SBE) SBE Office of Multidisciplinary Activities (SMA)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Sebastian William Pattinson (Cambridge, Massachusetts); Anastasios John Hart (Waban, Massachusetts)
ABSTRACT	Methods, systems, and devices for extrusion-based three-dimensional printing are provided. The methods, systems, and devices allow for the printing materials such as fabrics, clothing, and wearable and/or implantable devices. A number of different enhancements are provided that allow for this improved form of three-dimensional printing, including: (1) printing using a polymer (e.g., cellulose acetate) dissolved in a solvent (e.g., acetone); (2) selectively bonding portions of a deposited filament onto one or more surfaces and/or one or more previously deposited filaments; (3) using particular toolpaths to create a fabric or similar material by creating a woven pattern; and (4) printing across multiple layers even when previous layers are not complete. Other aspects of the present disclosure, including other enhancements and various printer configurations, are also provided.
FILED	Monday, December 12, 2016
APPL NO	15/376416
ART UNIT	1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/06 (20130101) A61F 2/0063 (20130101) A61F 2/90 (20130101) A61F 2210/0057 (20130101) A61F 2240/002 (20130101) A61F 2250/0012 (20130101) A61F 2250/0023 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/20 (20170801) B29C 64/106 (20170801) B29C 64/118 (20170801) B29C 64/209 (20170801) B29C 64/232 (20170801) B29C 64/236 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2023/12 (20130101) B29K 2067/046 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/726 (20130101) B29L 2031/7534 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Original (OR) Class B33Y 30/00 (20141201) B33Y 80/00 (20141201)
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10696567 — Water treatment using an iron and clay-based sorption media

US 10696567	Chang et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Geosciences (GEO) Integrative and Collaborative Education and Research (ICER) Department of Transportation (USDOT) U.S. State Government State of Florida Florida Department of Transportation (FDOT)
APPLICANT(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
ASSIGNEE(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
INVENTOR(S)	Ni-Bin Chang (Winter Springs, Florida); Martin P. Wanielista (Winter Park, Florida)
ABSTRACT	A method of water treatment includes flowing water that includes nitrogen and phosphorus compounds through a sorption media composition within at least one chamber of a water treatment system. The composition comprises iron filings comprising at least 5 volume (vol) % of the composition, sand particles comprising at least 10 vol % of the composition; and clay particles comprising at least 2 vol % of the composition. The iron filings, sand particles, and clay particles are mixed together. During the flowing the clay particles attract the nitrogen and phosphorus compounds which become absorbed onto a surface of the iron filings and the clay resulting in a removal of the nitrogen and phosphorus compounds and the generation of reaction products. Nitrogen and phosphorus are then recovered from the reaction products.
FILED	Monday, April 29, 2019
APPL NO	16/398050
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 24/02 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/12 (20130101) B01J 20/043 (20130101) B01J 20/103 (20130101) B01J 20/0229 (20130101) B01J 20/28004 (20130101) B01J 20/28014 (20130101) B01J 20/28054 (20130101) B01J 2220/4825 (20130101) B01J 2220/4831 (20130101) B01J 2220/4893 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/281 (20130101) Original (OR) Class C02F 2101/105 (20130101) C02F 2101/163 (20130101) C02F 2103/001 (20130101) C02F 2201/002 (20130101)
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10696591 — Self-healing composite of thermoset polymer and programmed super contraction fibers

US 10696591	Li et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Guoqiang Li (Baton Rouge, Louisiana); Harper Meng (Baton Rouge, Louisiana)
ASSIGNEE(S)	Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana)
INVENTOR(S)	Guoqiang Li (Baton Rouge, Louisiana); Harper Meng (Baton Rouge, Louisiana)
ABSTRACT	A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and a component for molecular scale healing has the ability to repair structural defects by a bio-mimetic, close-then-heal process. The shape memory polymer serves to bring surfaces of a structural defect into proximity, after which the healing component moves into the defect and provides molecular scale healing. The component for molecular scale healing can be a thermoplastic, such as fibers, particles or spheres, which are heated to or above the thermoplastic's melting point, and then the composition is cooled below that melting temperature. The compositions can not only close macroscopic defects, but they can also do so repeatedly even if damage recurs in a previously healed/repaired area.
FILED	Thursday, March 14, 2019
APPL NO	16/353087
ART UNIT	1763 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 73/18 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 20/1037 (20130101) C04B 26/04 (20130101) C04B 26/16 (20130101) Original (OR) Class C04B 26/26 (20130101) C04B 28/02 (20130101) C04B 2103/0065 (20130101) C04B 2111/72 (20130101) C04B 2111/00612 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/10 (20130101) C08G 18/664 (20130101) C08G 18/3206 (20130101) C08G 18/3206 (20130101) C08G 18/4238 (20130101) C08G 18/7671 (20130101) C08G 2101/0025 (20130101) C08G 2280/00 (20130101) C08G 2350/00 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/12 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/70 (20130101)
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10696851 — Print-on pastes for modifying material properties of metal particle layers

US 10696851	Hardin et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	Hitachi Chemical Co., Ltd. (Tokyo, Japan)
ASSIGNEE(S)	Hitachi Chemical Co., Ltd. (Tokyo, Japan)
INVENTOR(S)	Brian E. Hardin (San Carlos, California); Erik Sauar (Oslo, Norway); Dhea Suseno (Oakland, California); Jesse J. Hinricher (Pipestone, Minnesota); Jennifer Huang (Saratoga, California); Tom Yu-Tang Lin (Berkeley, California); Stephen T. Connor (San Francisco, California); Daniel J. Hellebusch (Oakland, California); Craig H. Peters (Belmont, California)
ABSTRACT	Intercalation pastes for use with semiconductor devices are disclosed. The pastes contain precious metal particles, intercalating particles, and an organic vehicle and can be used to improve the material properties of metal particle layers. Specific formulations have been developed to be screen-printed directly onto a dried metal particle layer and fired to make a fired multilayer stack. The fired multilayer stack can be tailored to create a solderable surface, high mechanical strength, and low contact resistance. In some embodiments, the fired multilayer stack can etch through a dielectric layer to improve adhesion to a substrate. Such pastes can be used to increase the efficiency of silicon solar cells, specifically multi- and mono-crystalline silicon back-surface field (BSF), and passivated emitter and rear contact (PERC) photovoltaic cells. Other applications include integrated circuits and more broadly, electronic devices.
FILED	Wednesday, November 23, 2016
APPL NO	15/360955
ART UNIT	1761 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 1/02 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0016 (20130101) B23K 35/025 (20130101) B23K 35/286 (20130101) B23K 35/3006 (20130101) B23K 35/3612 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 8/16 (20130101) C03C 8/18 (20130101) C03C 2205/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 5/24 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/049 (20141201) H01L 31/0201 (20130101) H01L 31/0203 (20130101) H01L 31/1804 (20130101) H01L 31/022425 (20130101) H01L 31/022433 (20130101) H01L 31/022441 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/34 (20141201) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101)
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10696977 — Carbon fixation systems in plants and algae

US 10696977	Sayre et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E) Office of Science (DOE-SC) Basic Energy Sciences (BES) Energy Frontier Research Centers (EFRC) Center for Advanced Biofuel Systems (CABS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Emerging Frontiers (EF)
APPLICANT(S)	NMC, INC. (Los Alamos, New Mexico)
ASSIGNEE(S)	NCM, INC. (Los Alamos, New Mexico)
INVENTOR(S)	Richard Thomas Sayre (Los Alamos, New Mexico); Somya S. Subramanian (Los Alamos, New Mexico); Natalia Friedland (Los Alamos, New Mexico)
ABSTRACT	Provided are methods for elevating cyclic electron transfer activity, improving carbon concentration, and enhancing carbon fixation in C3 and C4 plants, and algae, and producing biomass or other products from C3 or C4 plants, and algae, selected from among, for example, starches, oils, fatty acids, lipids, cellulose or other carbohydrates, alcohols, sugars, nutraceuticals, pharmaceuticals, fragrance and flavoring compounds, and organic acids, as well as transgenic plants produced thereby. These methods and transgenic plants and algae encompass the expression, or overexpression, of various combinations of genes that improve carbon concentrating systems in plants and algae, such as bicarbonate transport proteins, carbonic anhydrase, light driven proton pump, cyclic electron flow regulators, etc.
FILED	Tuesday, March 19, 2019
APPL NO	16/358331
ART UNIT	1663 — Plants
CURRENT CPC	Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 1/00 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101)
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10697931 — Methods of particle manipulation and analysis

US 10697931	Ault et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	The Trustees of Princeton University (Princeton, New Jersey); University of Hawaii (Honolulu, Hawaii); UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Jesse Ault (Knoxville, Tennessee); Sangwoo Shin (Honolulu, Hawaii); Howard A. Stone (Princeton, New Jersey); Jie Feng (Princeton, New Jersey); Patrick Warren (Wirral, United Kingdom)
ABSTRACT	Methods described herein, in some embodiments, permit extraction of particle structural and/or surface charge data from gradient induced particle motion in channels. In one aspect, a method of manipulating particle motion comprises introducing a fluid into a channel, the fluid comprising particles, and driving particle accumulation to a preselected location in the channel by setting advective velocity of the fluid to offset diffusiophoretic mobility of the particles at the preselected location.
FILED	Wednesday, December 05, 2018
APPL NO	16/210760
ART UNIT	2877 — Optics
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/00 (20130101) G01N 15/1456 (20130101) G01N 27/44721 (20130101) Original (OR) Class G01N 2015/0053 (20130101)
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10699206 — Iterative probabilistic parameter estimation apparatus and method of use therefor

US 10699206	Teixeira
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	Rodrigo E. Teixeira (Madison, Alabama)
ASSIGNEE(S)
INVENTOR(S)	Rodrigo E. Teixeira (Madison, Alabama)
ABSTRACT	A probabilistic digital signal processor using data from multiple instruments is described. In one example, a digital signal processor is integrated into a biomedical device. The processor is configured to: use a dynamic state-space model configured with a physiological model of a body system to provide a prior probability distribution function; receive sensor data input from at least two data sources; and iteratively use a probabilistic updater to integrate the sensor data as a fused data set and generate a posterior probability distribution function using all of: (1) the fused data set; (2) an application of Bayesian probability; and (3) the prior probability distribution function. The processor further generates an output of a biomedical state using the posterior probability function.
FILED	Tuesday, February 27, 2018
APPL NO	15/906413
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/024 (20130101) A61B 5/029 (20130101) A61B 5/0402 (20130101) A61B 5/02055 (20130101) A61B 5/02416 (20130101) A61B 5/7264 (20130101) Electric Digital Data Processing G06F 15/18 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Original (OR) Class G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101)
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10700234 — Fabrication processes for effectively transparent contacts

US 10700234	Saive et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Rebecca Saive (Pasadena, California); Harry A. Atwater (South Pasadena, California); Sisir Yalamanchili (Pasadena, California); Colton Bukowsky (Pasadena, California); Thomas Russell (Pasadena, California)
ABSTRACT	In conventional solar cells with metal contacts, a non-negligible fraction of the incoming solar power is immediately lost either through absorption or reflection upon interaction with the contacts. Effectively transparent contacts (“ETCs”) for solar cells can be referred to as three-dimensional contacts designed to redirect incoming light onto a photoabsorbing surface of a solar cell. In many embodiments, the ETCs have triangular cross-sections. Such ETCs can be placed on a photoabsorbing surface such that at least one of their sides forms an angle with the photoabsorbing surface. In this configuration, the ETCs can redirect incident light onto the photoabsorbing surface, mitigating or eliminating reflection loss compared to conventional solar cells. When constructed in accordance with a number of embodiments of the invention, ETCs can be effectively transparent and highly conductive.
FILED	Friday, August 17, 2018
APPL NO	15/999264
ART UNIT	2812 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1884 (20130101) Original (OR) Class H01L 31/022425 (20130101) H01L 31/022466 (20130101)
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10700436 — Origami-folded antennas and methods for making the same

US 10700436	Georgakopoulos et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Stavros Georgakopoulos (Boca Raton, Florida); Xueli Liu (Miami, Florida)
ASSIGNEE(S)	The Florida International University Board of Trustees (Miami, Florida)
INVENTOR(S)	Stavros Georgakopoulos (Boca Raton, Florida); Xueli Liu (Miami, Florida)
ABSTRACT	Disclosed herein are polarization and frequency reconfigurable origami-folded antennas and methods for making the same. An origami-folded antenna can include at least one ground plane that can include a dielectric stratum and a conductive stratum that is at least partially disposed on the conductive stratum. The origami-folded antenna can further include at least two helical sections that can include a dielectric sheet and a conductive sheet. The origami-folded antenna can be expanded to an expanded state and compressed to a compressed state along a center axis, and the antenna can have a greater length along the center axis when in the expanded state than when in the compressed state.
FILED	Thursday, January 03, 2019
APPL NO	16/238828
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 11/086 (20130101) Original (OR) Class H01Q 25/00 (20130101)
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10700792 — Programmable ultrasonic transceiver

US 10700792	Przybyla et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	Chirp Microsystems, Inc. (Berkeley, California)
ASSIGNEE(S)	CHIRP MICROSYSTEMS, INC. (Berkeley, California)
INVENTOR(S)	Richard Przybyla (Berkeley, California); Mitchell Kline (Berkeley, California); David Horsley (Berkeley, California)
ABSTRACT	An ultrasonic transceiver system includes a transmitter block, a receiver block, a state machine, a computer unit. The transmitter block contains circuitry configured to drive an ultrasound transducer. The receiver block contains circuitry configured to receive signals from the ultrasound transducer and convert the signals into digital data. The state machine is coupled to the transmitter and receiver blocks and contains circuitry configured to act as a controller for those blocks. The computing unit is coupled to the transmitter block, the receiver block, and the state machine and is configured to drive the transmitter block and process data received from the receiver block by executing instructions of a program. The program memory is coupled to the computing unit and is configured to store the program. The computing unit is configured to be reprogrammed with one or more additional programs stored in the program memory.
FILED	Tuesday, March 13, 2018
APPL NO	15/920300
ART UNIT	2436 — Cryptography and Security
CURRENT CPC	Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0207 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/523 (20130101) Electric Digital Data Processing G06F 8/65 (20130101) Transmission H04B 11/00 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101) H04L 9/0861 (20130101) H04L 9/0869 (20130101) H04L 27/34 (20130101) H04L 67/34 (20130101) Wireless Communication Networks H04W 12/02 (20130101) H04W 88/02 (20130101)
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10700800 — Estimating frequency-offsets and multi-antenna channels in MIMO OFDM systems

US 10700800	Giannakis et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Georgios B. Giannakis (Minnetonka, Minnesota); Xiaoli Ma (Auburn, Alabama)
ABSTRACT	Techniques are described for carrier frequency offset (CFO) and channel estimation of orthogonal frequency division multiplexing (OFDM) transmissions over multiple-input multiple-output (MIMO) frequency-selective fading channels. A wireless transmitter forms blocks of symbols by inserting training symbols within two or more blocks of information-bearing symbols. The transmitter applies a hopping code to each of the blocks of symbols to insert a null subcarrier at a different position within each of the blocks of symbols, and a modulator outputs a wireless signal in accordance with the blocks of symbols. A receiver receives the wireless signal and estimates the CFO, and outputs a stream of estimated symbols based on the estimated CFO.
FILED	Tuesday, May 24, 2016
APPL NO	15/162978
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 7/046 (20130101) H04B 7/063 (20130101) H04B 7/066 (20130101) H04B 7/0413 (20130101) Multiplex Communication H04J 11/0063 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0016 (20130101) H04L 25/0202 (20130101) H04L 25/0206 (20130101) H04L 25/0228 (20130101) H04L 25/0242 (20130101) H04L 27/2607 (20130101) H04L 27/2613 (20130101) H04L 27/2626 (20130101) H04L 27/2657 (20130101) H04L 27/2671 (20130101) H04L 27/2672 (20130101) H04L 27/2675 (20130101) H04L 27/2692 (20130101) H04L 27/2695 (20130101)
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10701662 — Methods and apparatus for wideband localization

US 10701662	Luo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Zhihong Luo (Berkeley, California); Qiping Zhang (Austin, Texas); Nicholas Selby (Cambridge, Massachusetts); Yunfei Ma (Santa Clara, California); Manish Singh (Delhi, India); Fadel Adib (Cambridge, Massachusetts)
ABSTRACT	A wideband, radio-frequency localization system may estimate the one-dimensional, two-dimensional or three-dimensional position and trajectory of a static or moving object. These estimates may have a high spatial accuracy and low latency. The localization may be determined based on phase or amplitude of a wideband signal in each frequency band in a set of multiple frequency bands. The localization may be based on a single shot of measurements across a wide band of radio frequencies, without frequency hopping. The measurements of the wideband signal may be taken over time and over space at multiple receivers. The localization may be based on measurements taken while a backscatter node remains in a first reflective state or in a second reflective state, rather than when the backscatter node is transitioning between reflective states. In some cases, the localization achieves sub-centimeter spatial resolution in each of three spatial dimensions.
FILED	Thursday, December 26, 2019
APPL NO	16/727727
ART UNIT	2643 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0221 (20130101) G01S 5/0278 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0007 (20130101) H04L 27/265 (20130101) Wireless Communication Networks H04W 64/006 (20130101) Original (OR) Class
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National Aeronautics and Space Administration (NASA)

10694974 — Method and system for MRI-based targeting, monitoring, and quantification of thermal and mechanical bioeffects in tissue induced by high intensity focused ultrasound

US 10694974	Partanen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Aeronautics and Space Administration (NASA) National Space Biomedical Research Institute (NSBRI)
APPLICANT(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington); KONINKLIJKE PHILIPS N.V. (Eindhoven, Netherlands)
ASSIGNEE(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington); KONINKLIJKE PHILIPS N.V. (Eindhoven, Netherlands)
INVENTOR(S)	Ari Partanen (Andover, Massachusetts); Vera Khokhlova (Seattle, Washington); Navid Farr (Seattle, Washington); Donghoon Lee (Seattle, Washington); Wayne Kreider (Seattle, Washington); Tatiana Khokhlova (Seattle, Washington); Adam Maxwell (Seattle, Washington); Yak-Nam Wang (Seattle, Washington); George Schade (Seattle, Washington); Michael Bailey (Seattle, Washington)
ABSTRACT	Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as “boiling histotripsy” (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.
FILED	Friday, March 27, 2015
APPL NO	15/120812
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/015 (20130101) A61B 5/0042 (20130101) A61B 5/055 (20130101) Original (OR) Class A61B 5/4836 (20130101) A61B 2090/374 (20160201) A61B 2576/026 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/288 (20130101) G01R 33/4804 (20130101) G01R 33/4814 (20130101) G01R 33/5602 (20130101) G01R 33/56341 (20130101)
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10696080 — Method and stamp for repeatable image correlation micro patterning and resulting specimen produced therefrom

US 10696080	Cannon et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	1900 LLC (Clemson, South Carolina); UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
ASSIGNEE(S)	1900 LLC (Clemson, South Carolina)
INVENTOR(S)	Andrew H Cannon (Anderson, South Carolina); March C Maguire (Clemson, South Carolina); Jacob D Hochhalter (Hampton, Virginia)
ABSTRACT	A method and surface micro patterned stamp for patterning image correlation test specimens is disclosed. The stamp may be formed and applied to the surface of structural components and laboratory test specimens in a repeatable fashion while reducing requisite infrastructure and time. The resulting test specimen incorporating the surface micro stamped pattern is also disclosed.
FILED	Tuesday, February 16, 2016
APPL NO	15/044749
ART UNIT	2853 — Printing/Measuring and Testing
CURRENT CPC	Processes for the Manufacture or Reproduction of Printing Surfaces B41C 1/06 (20130101) Printing Plates or Foils; Materials for Surfaces Used in Printing Machines for Printing, Inking, Damping, or the Like; Preparing Such Surfaces for Use and Conserving Them B41N 1/00 (20130101) Original (OR) Class Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0017 (20130101)
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10696423 — Method for transferring a spacecraft from geosynchronous transfer orbit to lunar orbit

US 10696423	Genova et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	USA as Represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as Represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Anthony L. Genova (Palo Alto, California); Scott Mitchell (Louisville, Colorado)
ABSTRACT	Method for placing a spacecraft into a lunar orbit, either by standard (i.e., impulsive) or ballistic (i.e., non-impulsive) capture, from an Earth orbit that is significantly inclined relative to the lunar orbit plane, with no constraint on the local time of perigee for the starting orbit.
FILED	Tuesday, January 03, 2017
APPL NO	15/397653
ART UNIT	3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/007 (20130101) Original (OR) Class B64G 1/10 (20130101) B64G 1/242 (20130101)
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10696591 — Self-healing composite of thermoset polymer and programmed super contraction fibers

US 10696591	Li et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Guoqiang Li (Baton Rouge, Louisiana); Harper Meng (Baton Rouge, Louisiana)
ASSIGNEE(S)	Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana)
INVENTOR(S)	Guoqiang Li (Baton Rouge, Louisiana); Harper Meng (Baton Rouge, Louisiana)
ABSTRACT	A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and a component for molecular scale healing has the ability to repair structural defects by a bio-mimetic, close-then-heal process. The shape memory polymer serves to bring surfaces of a structural defect into proximity, after which the healing component moves into the defect and provides molecular scale healing. The component for molecular scale healing can be a thermoplastic, such as fibers, particles or spheres, which are heated to or above the thermoplastic's melting point, and then the composition is cooled below that melting temperature. The compositions can not only close macroscopic defects, but they can also do so repeatedly even if damage recurs in a previously healed/repaired area.
FILED	Thursday, March 14, 2019
APPL NO	16/353087
ART UNIT	1763 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 73/18 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 20/1037 (20130101) C04B 26/04 (20130101) C04B 26/16 (20130101) Original (OR) Class C04B 26/26 (20130101) C04B 28/02 (20130101) C04B 2103/0065 (20130101) C04B 2111/72 (20130101) C04B 2111/00612 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/10 (20130101) C08G 18/664 (20130101) C08G 18/3206 (20130101) C08G 18/3206 (20130101) C08G 18/4238 (20130101) C08G 18/7671 (20130101) C08G 2101/0025 (20130101) C08G 2280/00 (20130101) C08G 2350/00 (20130101) Compositions of Macromolecular Compounds C08L 75/04 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/12 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/70 (20130101)
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10697373 — Active combustion control valve, system and method

US 10697373	Burkhardt et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	WASK Engineering Inc. (Cameron Park, California)
ASSIGNEE(S)	WASK ENGINEERING INC. (Cameron Park, California)
INVENTOR(S)	Wendelin M. Burkhardt (Cameron Park, California); John M. Crapuchettes (Boise, Idaho)
ABSTRACT	Various examples of an active combustion control valve, combustion systems, and method of controlling the flow of liquid fluid in a gas combustion system are described. In one aspect of the present invention, an active combustion control valve includes a core valve housing, an actuator, a valve seat in communication with the actuator, and a passageway in fluid communication with the core valve housing and the valve seat. The control valve is responsive to change in voltage applied to the actuator and is capable of a first condition permitting a first fluid flow through the passageway and a second condition permitting a second fluid flow through the passageway, the first fluid flow being different than the second fluid flow. The combustion control valve is small, robust, responsive and self-cooling to operate in severe thermal environment.
FILED	Monday, June 27, 2016
APPL NO	15/193467
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/232 (20130101) Original (OR) Class F02C 9/26 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/35 (20130101) F05D 2260/964 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 31/007 (20130101)
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10697890 — Apparatus and method of hydroxyl detection

US 10697890	Bailey et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Steven A. Bailey (Gambrills, Maryland); Thomas F. Hanisco (Takoma Park, Maryland)
ABSTRACT	The present invention relates to measuring hydroxyl in an atmosphere, including forwarding sunlight and ultraviolet light into a gas cell; switching between nitrogen gas only, or nitrogen gas and water vapor, into the gas cell; emitting ultraviolet rays into the cell which breaks down the water vapor into hydroxyl; and detecting a difference between two states, including 1) an OFF state where only nitrogen gas does not react to the ultraviolet light or the sunlight and there is no OH filter and the detector detects light that OH absorbs; and 2) an ON state where the water vapor is broken down by the ultraviolet rays to produce hydroxyl, and the gas cell acts as an OH filter and does not detect the light that OH absorbs; where a difference in signals measured by the detector in the two states is proportional to a column abundance of OH in earth atmosphere.
FILED	Thursday, September 27, 2018
APPL NO	16/143762
ART UNIT	2884 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/33 (20130101) Original (OR) Class G01N 21/255 (20130101) G01N 33/0036 (20130101) G01N 2201/0233 (20130101) G01N 2201/0636 (20130101) G01N 2201/0648 (20130101)
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10698024 — Self-healing microchip

US 10698024	Han et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as Represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Jin-Woo Han (San Jose, California); Meyya Meyyappan (San Jose, California)
ABSTRACT	A self-healing microchip comprising a commercial-off-the-shelf (COTS) microchip lacking radiation shielding. The self-healing microchip includes one or more microheaters that are integrated directly upon a surface of the COTS microchip, a self-test circuit which detects a degradation in the COTS microchip, and one or more temperature sensors. The one or more microheaters may be formed directly upon a backside surface of the COTS microchip using tungsten sputtered shadow mask patterning or by lithography and etching, for example. In response to a detected degradation in the COTS microchip, a temperature control configures an output temperature generated by the one or more microheaters and an amount of time at which the output temperature is maintained to cause annealing in the microchip responsive to the detected degradation in the COTS microchip.
FILED	Thursday, March 08, 2018
APPL NO	15/916174
ART UNIT	2867 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2644 (20130101) G01R 31/2856 (20130101) Original (OR) Class G01R 31/2863 (20130101) G01R 31/2874 (20130101) G01R 31/2875 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/345 (20130101) H01L 2224/16 (20130101) H01L 2224/48247 (20130101) H01L 2924/00 (20130101) H01L 2924/0002 (20130101)
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10699584 — Systems and methods for sonic boom aware flight planning

US 10699584	Suddreth et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Neil A Armstrong Flight Research Center (AFRC)
APPLICANT(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
ASSIGNEE(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
INVENTOR(S)	John G. Suddreth (Cave Creek, Arizona); Jerry Ball (Peoria, Arizona); Troy Nichols (Peoria, Arizona); Mark A. Giddings (Mesa, Arizona)
ABSTRACT	Flight planning systems and methods are provided, which augment supersonic flight planning via the integration of sonic boom forecast data. In embodiments, the flight planning system includes a display device, a pilot input interface, and a controller architecture coupled to the display device and to the pilot input interface. During system operation, the controller architecture receives flight plan criteria entered via the pilot input interface. The controller architecture then endeavors to generate or construct a boom-regulated flight plan, which includes at least one supersonic flight plan segment, in accordance with the flight plan criteria. If unable to construct a boom-regulated flight plan, the controller architecture generates a visual notification on the display device. The visual notification can include, for example, a warning that an excessive sonic boom or overpressure event may occur during execution of the flight plan by an aircraft, absent modifications to the flight plan.
FILED	Friday, March 02, 2018
APPL NO	15/910072
ART UNIT	3668 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 30/00 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 23/005 (20130101) Traffic Control Systems G08G 5/0021 (20130101) G08G 5/0034 (20130101) G08G 5/0039 (20130101) Original (OR) Class G08G 5/0052 (20130101) G08G 5/0073 (20130101)
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10701570 — Receivers incorporating unequally spaced constellations that provide reduced SNR requirements as compared to equally spaced constellations

US 10701570	Barsoum et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	Constellation Designs, LLC (Anaheim, California)
ASSIGNEE(S)	Constellation Designs, LLC (Anaheim, California)
INVENTOR(S)	Maged F. Barsoum (San Jose, California); Christopher R. Jones (Pacific Palisades, California)
ABSTRACT	Communication systems are described that use unequally spaced constellations that have increased capacity compared to conventional constellations operating within a similar SNR band. One embodiment is a digital communications system including a transmitter transmitting signals via a communication channel, the transmitter including a coder capable of receiving user bits and outputting encoded bits at a rate, a mapper capable of mapping encoded bits to symbols in a constellation, and a modulator capable of generating a modulated signal for transmission via the communication channel using symbols generated by the mapper, wherein the constellation is unequally spaced and characterizable by assignment of locations and labels of constellation points to maximize parallel decode capacity of the constellation at a given signal-to-noise ratio so that the constellation provides a given capacity at a reduced signal-to-noise ratio compared to a uniform constellation that maximizes the minimum distance between constellation points of the uniform constellation.
FILED	Friday, December 27, 2019
APPL NO	16/729171
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 15/00 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) H04L 1/0009 (20130101) H04L 27/3405 (20130101) H04L 27/3483 (20130101) Wireless Communication Networks H04W 24/02 (20130101) Original (OR) Class
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Department of Homeland Security (DHS)

10697834 — Contrast phantoms and uses thereof for active millimeter wave imaging systems

US 10697834	Barber
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	Jeffrey Brian Barber (Vineland, New Jersey)
ABSTRACT	The present disclosure is directed to a contrast phantom having a first region with a first reflection coefficient, a second region with a second reflection coefficient, and a third region with a third reflection coefficient, wherein the first reflection coefficient, the second reflection coefficient and the third reflection coefficient are increasing or decreasing in value in discrete steps, and wherein at least one of the regions includes an electrically conductive material having a thickness of about 200 μm. Methods of testing the contrast resolution of an active millimeter wave imaging system using the contrast phantom are also described.
FILED	Tuesday, February 19, 2019
APPL NO	16/279380
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/046 (20130101) G01J 5/522 (20130101) Original (OR) Class G01J 2005/0048 (20130101) G01J 2005/0077 (20130101)
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10697952 — Determining the age of a tunnel

US 10697952	Latham
FUNDED BY	Department of Homeland Security (DHS) Science and Technology Directorate (DHS-ST)
APPLICANT(S)	The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S)	The MITRE Corporation (McLean, Virginia)
INVENTOR(S)	Robert Latham (Springfield, Virginia)
ABSTRACT	Method, systems, and techniques for determining the age of an underground space are provided. In some embodiments, determining the age of an underground space comprises taking soil samples from a plurality of surface locations within a second underground space, analyzing the soil samples from the plurality of surface locations to determine an amount of a chemical compound for each soil sample, and determining an age of the second underground space using one or more relationships based on amounts of the chemical compound measured in a plurality of soil samples taken over a period of time in a first underground space and a baseline amount of the chemical compound at one or more locations remote from both the first underground space and the second underground space.
FILED	Monday, May 07, 2018
APPL NO	15/973166
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/79 (20130101) G01N 21/3563 (20130101) G01N 23/223 (20130101) G01N 23/2076 (20130101) G01N 33/24 (20130101) Original (OR) Class G01N 2021/3572 (20130101)
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10698121 — 10B enriched plastic scintillators for application in thermal neutron detection, methods of making and using the same

US 10698121	Sellinger et al.
FUNDED BY	Department of Homeland Security (DHS) Department of Defense (DOD) Defense Threat Reduction Agency (DTRA)
APPLICANT(S)	Alan Sellinger (Golden, Colorado); Uwe Greife (Golden, Colorado); Henok A. Yemam (Golden, Colorado); Adam Mahl (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S)	Alan Sellinger (Golden, Colorado); Uwe Greife (Golden, Colorado); Henok A. Yemam (Golden, Colorado); Adam Mahl (Denver, Colorado)
ABSTRACT	The present invention relates to a ¹⁰B enriched plastic scintillators, methods of making the same and methods of using the same. Neither carboranes nor ³He are required to be included in the plastic scintillators, which can be used in neutron detection.
FILED	Tuesday, August 07, 2018
APPL NO	16/057793
ART UNIT	2884 — Optics
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Measurement of Nuclear or X-radiation G01T 1/2033 (20130101) Original (OR) Class G01T 3/06 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 4/00 (20130101)
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10701261 — Method, system and computer program product for selective image capture

US 10701261	Lai et al.
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Jui-Hsin Lai (White Plains, New York); Ching-Yung Lin (Scarsdale, New York); Wan-Yi Lin (White Plains, New York)
ABSTRACT	A method includes analyzing a preview image made by an image sensor when operating in a preview image mode to determine if the preview image contains some portion that corresponds to information that is considered not subject to being imaged. The method further includes, if it is determined that the preview image does comprise some image portion that corresponds to information that is considered not subject to being imaged, disabling the image sensor from capturing an image that would correspond to the preview image. Analyzing can include accessing a data storage that contains representations of information that is considered not subject to being imaged for comparison with image features extracted from the preview image, where the data storage is at least one of contained in a device that also contains the image sensor, or is located remotely from the device and can be accessed via a wireless connection.
FILED	Monday, August 01, 2016
APPL NO	15/224851
ART UNIT	2698 — Selective Visual Display Systems
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00456 (20130101) G06K 2209/01 (20130101) G06K 2209/25 (20130101) Pictorial Communication, e.g Television H04N 5/232 (20130101) H04N 5/23216 (20130101) H04N 5/23222 (20130101) Original (OR) Class H04N 5/23258 (20130101) H04N 5/23293 (20130101)
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Department of Agriculture (USDA)

10694692 — Plant varieties by application of endocides

US 10694692	Li et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Stephen F. Austin State University (Nacogdoches, Texas)
ASSIGNEE(S)	Stephen F. Austin State University (Nacogdoches, Texas)
INVENTOR(S)	Shiyou Li (Nacogdoches, Texas); Ping Wang (Nacogdoches, Texas); Zushang Su (Nacogdoches, Texas)
ABSTRACT	The present invention relates generally to compositions and methods for mutating a plant and plants and plant products produced by said methods. Also, compositions and methods for controlling a plant species are disclosed herein.
FILED	Thursday, November 10, 2016
APPL NO	15/775570
ART UNIT	1663 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/06 (20130101) Original (OR) Class Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/40 (20130101) A01N 43/40 (20130101) Mixtures of Fertilisers Covered Individually by Different Subclasses of Class C05; Mixtures of One or More Fertilisers With Materials Not Having a Specific Fertilising Activity, e.g Pesticides, Soil-conditioners, Wetting Agents; Fertilisers Characterised by Their Form C05G 3/00 (20130101)
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10694993 — Methods of determining energy balance using breath carbon isotope ratios

US 10694993	Butz et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin); The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	Daniel Elmer Butz (Madison, Wisconsin); Leah D. Whigham (El Paso, Texas); Mark E. Cook (Madison, Wisconsin); Warren Paul Porter (Fitchburg, Wisconsin); David H. Abbott (Madison, Wisconsin); Dale A. Schoeller (Belleville, Wisconsin)
ABSTRACT	Described herein are methods of determining energy balance in individuals such as exercising individuals, individuals consuming a ¹³C-enriched test composition and individuals consuming a fixed diet with a known δ¹³C. The δ¹³C pre- and post-exercise, or pre- and post-consumption of the test beverage or fixed diet indicate whether the individual is in neutral or positive energy balance, or in energy deficit. The methods are particularly useful for individuals participating in weight management programs, and individuals under the care of health care professionals.
FILED	Wednesday, August 08, 2018
APPL NO	16/058059
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/082 (20130101) A61B 5/486 (20130101) Original (OR) Class A61B 5/4866 (20130101) Veterinary Instruments, Implements, Tools, or Methods A61D 99/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 41/0028 (20130101) A61K 49/0004 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/004 (20130101) G01N 33/497 (20130101)
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10697014 — Genomic regions with epigenetic variation that contribute to phenotypic differences in livestock

US 10697014	DeChow et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Chad DeChow (Julian, Pennsylvania); Wansheng Liu (State College, Pennsylvania); Jurg W. Blum (Vettlingen, Switzerland); Craig Baumrucker (State College, Pennsylvania); Ti-Cheng Chang (State College, Pennsylvania)
ABSTRACT	The invention provides compositions and methods for selecting milk-producing livestock with a preferred phenotype. In one embodiment, the method includes detecting methylation status of one or more genes and gene regulatory regions in a sample to identify the preferred phenotype.
FILED	Friday, December 02, 2016
APPL NO	15/368073
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Original (OR) Class C12Q 2600/154 (20130101)
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Department of Veterans Affairs (DVA)

10694999 — Conductive layer formed strain gauge and method of making same

US 10694999	Majerus et al.
FUNDED BY	Department of Veterans Affairs (DVA) Rehabilitation Research and Development Service (RR&DS)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio); The United States as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
INVENTOR(S)	Steve J A Majerus (University Heights, Ohio); Jeremy Dunning (Cleveland Heights, Ohio); Katherine M. Bogie (Cleveland, Ohio); Joseph A. Potkay (Plymouth, Michigan)
ABSTRACT	A sensor apparatus includes at least one substrate layer of an elastically deformable material, the substrate layer extending longitudinally between spaced apart ends thereof. A conductive layer is attached to and extends longitudinally between the spaced apart ends of the at least one substrate layer. The conductive layer includes an electrically conductive material adapted to form a strain gauge having an electrical resistance that varies based on deformation of the conductive layer in at least one direction.
FILED	Friday, October 12, 2018
APPL NO	16/159010
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/026 (20130101) A61B 5/683 (20130101) Original (OR) Class A61B 5/02141 (20130101) A61B 5/02444 (20130101) A61B 5/6876 (20130101) A61B 2562/12 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 9/0052 (20130101)
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10695239 — Collapsible manual wheelchair system for improved propulsion and transfers

US 10695239	Hansen et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Andrew H. Hansen (Minneapolis, Minnesota); Gary D. Goldish (Minneapolis, Minnesota); Eric Nickel (Minneapolis, Minnesota)
ABSTRACT	A manual wheelchair including a collapsible frame with at least one brace connected to at least one of the frame members. A drive wheel axel extends along a first axis of rotation and engages a drive wheel, the first brace, and a portion of a transmission. A push rim axel extends along a second axis of rotation and engages a push rim wheel, the second brace, and a portion of the transmission, which transmits rotation of the push rim to rotation of the drive wheel. The at least one brace is configured to release the at least one of the frame members to collapse the wheelchair.
FILED	Friday, May 25, 2018
APPL NO	15/990381
ART UNIT	3618 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/023 (20130101) Original (OR) Class A61G 5/026 (20130101) A61G 5/0825 (20161101) A61G 5/0875 (20161101) A61G 5/1054 (20161101)
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10695401 — Use of vimentin in the modulation of acute inflammation and thrombosis

US 10695401	Lam et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Baylor College of Medicine (Houston, Texas)
ASSIGNEE(S)	Baylor College of Medicine (Houston, Texas)
INVENTOR(S)	Fong Wilson Lam (Houston, Texas); Qi Da (Houston, Texas); Miguel A. Cruz (Pearland, Texas)
ABSTRACT	Embodiments of the disclosure include methods and compositions for treating or preventing acute inflammation using soluble vimentin. In specific embodiments, a vimentin derivative comprising the rod domain is utilized for treating or preventing any disease in which a decrease in leukocyte adhesion is therapeutic. In specific embodiments, a fragment of vimentin that comprises part or all of the rod domain is employed.
FILED	Thursday, November 30, 2017
APPL NO	16/465071
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101)
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Small Business Administration (SBA)

10695415 — Live attenuated oral vaccine against shigellosis and typhoid fever

US 10695415	Wu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Protein Potential, LLC (Rockville, Maryland)
ASSIGNEE(S)	Protein Potential, LLC (Rockville, Maryland)
INVENTOR(S)	Yun Wu (Rockville, Maryland); Dennis J. Kopecko (Silver Spring, Maryland); B. Kim Lee Sim (Gaithersburg, Maryland); Stephen L. Hoffman (Gaithersburg, Maryland)
ABSTRACT	Disclosed is the attenuated Salmonella typhi vaccine Ty21a utilized as a vector for Shigella and/or enterotoxogenic E. coli genes stably integrated in the Ty21a chromosome. These genes include a heterologous Shigella sonnei O-antigen biosynthetic gene region that comprises the wzz gene and expresses Shigella sonnei form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system.
FILED	Wednesday, July 06, 2016
APPL NO	15/742459
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/116 (20130101) A61K 39/0275 (20130101) A61K 39/0283 (20130101) Original (OR) Class A61K 2039/70 (20130101) A61K 2039/522 (20130101) A61K 2039/523 (20130101) A61K 2039/543 (20130101) Technologies for Adaptation to Climate Change Y02A 50/476 (20180101) Y02A 50/484 (20180101)
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10696673 — Bicyclic inhibitors of histone deacetylase

US 10696673	Fuller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Rodin Therapeutics, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)	Rodin Therapeutics, Inc. (Waltham, Massachusetts)
INVENTOR(S)	Nathan Oliver Fuller (Arlington, Massachusetts); John A. Lowe, III (Stonington, Connecticut)
ABSTRACT	Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
FILED	Tuesday, November 12, 2019
APPL NO	16/681213
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 487/04 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10700639 — Subcritical-voltage magnetron RF power source

US 10700639	Kazakevich et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Small Business Administration (SBA) Small Business Technology Transfer (STTR)
APPLICANT(S)	Muons, Inc. (Batavia, Illinois)
ASSIGNEE(S)	Muons, Inc. (Batavia, Illinois)
INVENTOR(S)	Grigory M. Kazakevich (North Aurora, Illinois); Michael L. Neubauer (San Francisco, California); Valeri A. Lebedev (Wheaton, Illinois); Vyacheslav P. Yakovlev (Batavia, Illinois)
ABSTRACT	A system and method of operating a magnetron power source can achieve a broad range of output power control by operating a magnetron with its cathode voltage lower than that needed for free running oscillations (e.g., below the Kapitsa critical voltage or equivalently below the Hartree voltage) A sufficiently strong injection-locking signal enables the output power to be coherently generated and to be controlled over a broad power range by small changes in the cathode voltage. In one embodiment, the present system and method is used for a practical, single, frequency-locked 2-magnetron system design.
FILED	Friday, August 02, 2019
APPL NO	16/530646
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 9/10 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/02 (20130101) H05H 2007/025 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Transportation (USDOT)

10696567 — Water treatment using an iron and clay-based sorption media

US 10696567	Chang et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Geosciences (GEO) Integrative and Collaborative Education and Research (ICER) Department of Transportation (USDOT) U.S. State Government State of Florida Florida Department of Transportation (FDOT)
APPLICANT(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
ASSIGNEE(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
INVENTOR(S)	Ni-Bin Chang (Winter Springs, Florida); Martin P. Wanielista (Winter Park, Florida)
ABSTRACT	A method of water treatment includes flowing water that includes nitrogen and phosphorus compounds through a sorption media composition within at least one chamber of a water treatment system. The composition comprises iron filings comprising at least 5 volume (vol) % of the composition, sand particles comprising at least 10 vol % of the composition; and clay particles comprising at least 2 vol % of the composition. The iron filings, sand particles, and clay particles are mixed together. During the flowing the clay particles attract the nitrogen and phosphorus compounds which become absorbed onto a surface of the iron filings and the clay resulting in a removal of the nitrogen and phosphorus compounds and the generation of reaction products. Nitrogen and phosphorus are then recovered from the reaction products.
FILED	Monday, April 29, 2019
APPL NO	16/398050
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 24/02 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/12 (20130101) B01J 20/043 (20130101) B01J 20/103 (20130101) B01J 20/0229 (20130101) B01J 20/28004 (20130101) B01J 20/28014 (20130101) B01J 20/28054 (20130101) B01J 2220/4825 (20130101) B01J 2220/4831 (20130101) B01J 2220/4893 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/281 (20130101) Original (OR) Class C02F 2101/105 (20130101) C02F 2101/163 (20130101) C02F 2103/001 (20130101) C02F 2201/002 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10698760 — System and method for automated and intelligent quantitative risk assessment of infrastructure systems

US 10698760	Acharya et al.
FUNDED BY	Department of Transportation (USDOT) Pipeline and Hazardous Materials Safety Administration (PHMSA)
APPLICANT(S)	GAS TECHNOLOGY INSTITUTE (Des Plaines, Illinois)
ASSIGNEE(S)	GAS TECHNOLOGY INSTITUTE (Des Plaines, Illinois)
INVENTOR(S)	Saurav Acharya (Des Plaines, Illinois); Ernest Lever (Arlington Heights, Illinois); Robert Marros (Chicago, Illinois)
ABSTRACT	An automated and intelligent quantitative system and method for assessing risk in infrastructure systems including, but not limited to, gas, electric, water, sewer, transportation, and/or telecommunication systems. The invention incorporates a graph-based data structure of multiple infrastructure systems. The graph-based data structure includes a multi-layered structure with each layer having nodes for components of one of the multiple infrastructure systems, and edge links between related pairs of the nodes. A spatio-temporal and ontological reasoner performs spatial and temporal reasoning on the graph-based data structure to identify nodes of the graph-based data structure likely affected by the new activity event.
FILED	Monday, February 26, 2018
APPL NO	15/905070
ART UNIT	2114 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Electric Digital Data Processing G06F 11/0796 (20130101) Original (OR) Class G06F 2201/805 (20130101) Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) G06N 5/045 (20130101) G06N 7/005 (20130101) G06N 20/20 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Commerce (DOC)

10697085 — Defect reduction in seeded aluminum nitride crystal growth

US 10697085	Bondokov et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	Robert T. Bondokov (Watervliet, New York); Kenneth E. Morgan (Castleton, New York); Leo J. Schowalter (Latham, New York); Glen A. Slack (Scotia, New York)
ASSIGNEE(S)	CRYSTAL IS, INC. (Green Island, New York)
INVENTOR(S)	Robert T. Bondokov (Watervliet, New York); Kenneth E. Morgan (Castleton, New York); Leo J. Schowalter (Latham, New York); Glen A. Slack (Scotia, New York)
ABSTRACT	Bulk single crystal of aluminum nitride (AlN) having an areal planar defect density≤100 cm⁼². Methods for growing single crystal aluminum nitride include melting an aluminum foil to uniformly wet a foundation with a layer of aluminum, the foundation forming a portion of an AlN seed holder, for an AlN seed to be used for the AlN growth. The holder may consist essentially of a substantially impervious backing plate.
FILED	Monday, October 15, 2018
APPL NO	16/160158
ART UNIT	1714 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/00 (20130101) C30B 23/025 (20130101) Original (OR) Class C30B 29/403 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02389 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2982 (20150115)
VIEW PATENT	@ USPTO: Full Text PDF

Non-Profit Organization (NPO)

10695380 — Cryopreservation of encapsulated pancreatic endoderm cells

US 10695380	Agulnick et al.
FUNDED BY	Non-Profit Organization (NPO) California Institute for Regenerative Medicine (CIRM)
APPLICANT(S)	ViaCyte, Inc. (San Diego, California)
ASSIGNEE(S)	ViaCyte, Inc. (San Diego, California)
INVENTOR(S)	Alan Agulnick (San Diego, California); Laura Martinson (San Diego, California); Evert Kroon (San Diego, California); Michael Scott (San Diego, California); Chad Green (San Diego, California)
ABSTRACT	Disclosed herein are methods for cryopreserving, hibernation and room temperature storage of PEC aggregates, implantable semipermeable devices and the VC combination product.
FILED	Thursday, October 26, 2017
APPL NO	15/795113
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) A01N 1/0278 (20130101) A01N 1/0284 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/39 (20130101) Original (OR) Class A61K 38/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0678 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

U.S. State Government

10696567 — Water treatment using an iron and clay-based sorption media

US 10696567	Chang et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Geosciences (GEO) Integrative and Collaborative Education and Research (ICER) Department of Transportation (USDOT) U.S. State Government State of Florida Florida Department of Transportation (FDOT)
APPLICANT(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
ASSIGNEE(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
INVENTOR(S)	Ni-Bin Chang (Winter Springs, Florida); Martin P. Wanielista (Winter Park, Florida)
ABSTRACT	A method of water treatment includes flowing water that includes nitrogen and phosphorus compounds through a sorption media composition within at least one chamber of a water treatment system. The composition comprises iron filings comprising at least 5 volume (vol) % of the composition, sand particles comprising at least 10 vol % of the composition; and clay particles comprising at least 2 vol % of the composition. The iron filings, sand particles, and clay particles are mixed together. During the flowing the clay particles attract the nitrogen and phosphorus compounds which become absorbed onto a surface of the iron filings and the clay resulting in a removal of the nitrogen and phosphorus compounds and the generation of reaction products. Nitrogen and phosphorus are then recovered from the reaction products.
FILED	Monday, April 29, 2019
APPL NO	16/398050
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 24/02 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/12 (20130101) B01J 20/043 (20130101) B01J 20/103 (20130101) B01J 20/0229 (20130101) B01J 20/28004 (20130101) B01J 20/28014 (20130101) B01J 20/28054 (20130101) B01J 2220/4825 (20130101) B01J 2220/4831 (20130101) B01J 2220/4893 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/281 (20130101) Original (OR) Class C02F 2101/105 (20130101) C02F 2101/163 (20130101) C02F 2103/001 (20130101) C02F 2201/002 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10697550 — Non-contact seal with progressive radial stop(s)

US 10697550	Chuong et al.
FUNDED BY
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Conway Chuong (Manchester, Connecticut); Ross Wilson (South Glastonbury, Connecticut)
ABSTRACT	An assembly for rotational equipment includes a plurality of seal shoes, a seal base, a plurality of spring elements and a frangible element. The seal shoes are arranged around an axis in an annular array. The seal base circumscribes the annular array of the seal shoes. Each of the spring elements is radially between and connects a respective one of the seal shoes and the seal base. A first of the spring elements includes a first mount, a second mount and a spring beam. The first mount is connected to a first of the seal shoes. The second mount is connected to the seal base. The spring beam extends longitudinally between and connects the first mount and the second mount. The frangible element is configured to restrict radial outward movement of the first of the seal shoes.
FILED	Thursday, August 15, 2019
APPL NO	16/541898
ART UNIT	3675 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/03 (20130101) F01D 11/14 (20130101) F01D 11/025 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/14 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2240/55 (20130101) Pistons; Cylinders; Sealings F16J 15/441 (20130101) F16J 15/442 (20130101) Original (OR) Class F16J 15/445 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10697953 — Portable apparatus for liquid chemical characterization

US 10697953	Weindorf et al.
FUNDED BY
APPLICANT(S)	Texas Tech University System (Lubbock, Texas)
ASSIGNEE(S)	Texas Tech University System (Lubbock, Texas)
INVENTOR(S)	David Weindorf (Lubbock, Texas); Delaina Pearson (Greenville, South Carolina); Somsubhra Chakraborty (West Bengal, India)
ABSTRACT	An apparatus or method determines a salinity or metal content a liquid sample by scanning the liquid sample using a PXRF spectrometer, receiving a PXRF spectra from the PXRF spectrometer, baseline correcting and smoothing the received PXRF spectra, extracting a Kα emission line of one or more elements from the baseline corrected and smoothed PXRF spectra using only one beam from the PXRF spectrometer, determining the salinity or the metal content of the liquid sample using the one or more processors and a predictive model that relates the Kα emission line of the one or more elements to the salinity or the metal content of the liquid sample, and providing the salinity or the metal content of the liquid sample to the one or more input/output interfaces.
FILED	Friday, October 19, 2018
APPL NO	16/165472
ART UNIT	2886 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/4406 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/274 (20130101) G01N 21/359 (20130101) G01N 23/223 (20130101) G01N 33/246 (20130101) Original (OR) Class G01N 2223/33 (20130101) G01N 2223/076 (20130101) G01N 2223/304 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10701367 — Method for encoding raw high frame rate video via an existing HD video architecture

US 10701367	Hook et al.
FUNDED BY
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Tyler L. Hook (Little Elm, Texas); David M. Zimmerman (La Mesa, California); Anthony Santamaria (Dallas, Texas)
ABSTRACT	A system for transporting fast frame rate video data from a high frame rate image sensor mosaics and spreads the fast frame rate video data in 1920×1080p30 video frames for transporting via an existing standard video architecture. Packing information, spreading information, and unique ID/timestamps for each frame is encoded in metadata and inserted in ancillary metadata space of the 1080p30 video frames. A robust encoding scheme generates the metadata and ensures that the transported video can be reassembled into its original fast frame rate form after being spread over multiple channels.
FILED	Wednesday, August 09, 2017
APPL NO	15/672499
ART UNIT	2487 — Recording and Compression
CURRENT CPC	Electric Digital Data Processing G06F 16/71 (20190101) Pictorial Communication, e.g Television H04N 7/015 (20130101) H04N 7/0102 (20130101) H04N 7/0122 (20130101) H04N 19/132 (20141101) H04N 19/154 (20141101) Original (OR) Class H04N 21/4342 (20130101) H04N 21/23602 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, June 30, 2020.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

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HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2020/fedinvent-patents-20200630.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

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