FedInvent™ Patents

Patent Details for Tuesday, August 11, 2020

This page was updated on Monday, March 27, 2023 at 06:09 AM GMT

Department of Health and Human Services (HHS)

10736494 — System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device

US 10736494	Gora et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Michalina Gora (Cambridge, Massachusetts); Guillermo J. Tearney (Cambridge, Massachusetts); Robert Carruth (Arlington, Massachusetts)
ABSTRACT	According to exemplary embodiments of the present disclosure, apparatus, device and method can be provided which can provide imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques in an automatic or semiautomatic manner. The exemplary apparatus, device and method can utilize a tethered capsule catheter with a mechanism for manual, semi-automatic or automatic traversing in the luminal organ with a controlled velocity and/or image quality. The exemplary apparatus can include feedback information about tension applied to the catheter during its movement that can be used to adjust velocity and assure patient comfort and safety for example during passing through natural sphincters and/or narrowing of the luminal organs and preventing from breaking of the catheter. The exemplary apparatus can also adjust velocity in order to provide good quality of acquired images, for example to engaged peristalsis and provide contact with the tissue. In one exemplary embodiment of the present disclosure, the exemplary mechanism for a controlled advancement of the catheter can be positioned outside of the patient's mouth, and can include a position sensor providing information about the position of the capsule in respect to the luminal organ for orientation of the acquired data.
FILED	Friday, January 30, 2015
APPL NO	15/115441
ART UNIT	3795 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/00009 (20130101) A61B 1/0016 (20130101) Original (OR) Class A61B 1/041 (20130101) A61B 5/0066 (20130101) A61B 5/0086 (20130101) A61B 5/6852 (20130101) A61B 2576/02 (20130101) Electric Digital Data Processing G06F 19/321 (20130101)
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10736512 — Systems and methods for visualizing ablated tissue

US 10736512	Mercader et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The George Washington University (Washington, District of Columbia)
ASSIGNEE(S)	The George Washington University (Washington, District of Columbia)
INVENTOR(S)	Marco A. Mercader (Arlington, Virginia); Matthew W. Kay (Kensington, Maryland); Narine Sarvazyan (Potomac, Maryland)
ABSTRACT	Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.
FILED	Friday, February 13, 2015
APPL NO	14/622477
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/06 (20130101) A61B 1/042 (20130101) A61B 1/043 (20130101) A61B 1/00045 (20130101) A61B 1/00082 (20130101) A61B 1/00165 (20130101) A61B 1/00186 (20130101) A61B 1/0638 (20130101) A61B 1/0646 (20130101) A61B 1/0669 (20130101) A61B 1/0676 (20130101) A61B 1/0684 (20130101) A61B 5/0071 (20130101) Original (OR) Class A61B 5/0084 (20130101) A61B 5/742 (20130101) A61B 5/1459 (20130101) A61B 5/4848 (20130101) A61B 5/6853 (20130101) A61B 5/14546 (20130101) A61B 18/00 (20130101) A61B 18/02 (20130101) A61B 18/1492 (20130101) A61B 2018/00357 (20130101) A61B 2018/00577 (20130101) A61B 2018/00982 (20130101)
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10736537 — Electrical impedance spectroscopy measurement based on concentric bipolar microelectrode sensor

US 10736537	Tai et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	California Institute of Technology (Pasadena, California); University of California Los Angeles (Los Angeles, California); University of Southern California (Los Angeles, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); UNIVERSITY OF CALIFORNIA LOS ANGELES (Los Angeles, California); UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
INVENTOR(S)	Yu-Chong Tai (Pasadena, California); Tzung Hsiai (Santa Monica, California); Yu Zhao (Shenhen, China PRC); Xiaoxiao Zhang (Los Angeles, California); Fei Yu (Chatsworth, California)
ABSTRACT	A portion of a concentric bipolar microelectrode sensor is attached to an inflatable balloon of a catheter. Another portion of the concentric bipolar microelectrode sensor is also attached to a body of the catheter. The inflatable balloon is guided to become in proximity of a tissue. The inflatable balloon is then inflated. The inflation increases the likelihood of contact between microelectrodes of the concentric bipolar microelectrode sensor with the tissue. A voltage is supplied to the microelectrodes. The tissue's impedance is accordingly measured over a frequency range. A disease of the tissue, such as a lesion, is diagnosed based on the measured impedance.
FILED	Monday, December 28, 2015
APPL NO	14/981089
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0538 (20130101) Original (OR) Class A61B 5/6853 (20130101)
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10736544 — Systems and methods for facilitating rehabilitation therapy

US 10736544	Cramer
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Steven C. Cramer (Irvine, California)
ABSTRACT	A rehabilitation system includes a portable patient workstation configured to facilitate in-home rehabilitation therapy. In some embodiments, the workstation includes a computing device and one or more rehabilitation devices. The computing device is configured to generate computer-based tasks associated with one or more in-home exercises. The rehabilitation devices, communicatively coupled to the computing device, includes a sensor that captures movement data for use in evaluating a patient's motor skills when instructed to perform one or more of the tasks.
FILED	Wednesday, May 23, 2018
APPL NO	15/987846
ART UNIT	3715 — Amusement and Education Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/0077 (20130101) A61B 5/486 (20130101) A61B 5/1121 (20130101) A61B 5/1124 (20130101) Original (OR) Class A61B 5/1128 (20130101) A61B 5/6887 (20130101) A61B 5/7445 (20130101) A61B 5/7475 (20130101) A61B 2505/09 (20130101) A61B 2562/0219 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 40/67 (20180101)
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10736553 — Method of manufacturing an analyte detector element

US 10736553	Lucisano et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	GlySens Incorporated (San Diego, California)
ASSIGNEE(S)	GlySens Incorporated (San Diego, California)
INVENTOR(S)	Joseph Lucisano (San Diego, California); Bahman Javidi (San Diego, California); Lev Kurbanyan (San Diego, California); Joe Lin (San Diego, California); Timothy Routh (San Diego, California); Bradley Walker (San Diego, California)
ABSTRACT	Enzymatic and non-enzymatic detectors and associated membrane apparatus, and methods of use, such as within a fully implantable sensor apparatus. In one embodiment, detector performance is controlled through selective use of membrane configurations and enzyme region shapes, which enable accurate detection of blood glucose level within the solid tissue of the living host for extended periods of time. Isolation between the host's tissue and the underlying enzymes and reaction byproducts used in the detectors is also advantageously maintained in one embodiment via use of a non-enzyme containing permeable membrane formed of e.g., a biocompatible crosslinked protein-based material. Control of response range and/or rate in some embodiments also permits customization of sensor elements. In one variant, heterogeneous detector elements are used to, e.g., accommodate a wider range of blood glucose concentration within the host. Methods of manufacturing the membranes and detectors, including methods to increase reliability, are also disclosed.
FILED	Monday, March 12, 2018
APPL NO	15/919052
ART UNIT	3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0031 (20130101) A61B 5/076 (20130101) A61B 5/1473 (20130101) A61B 5/6861 (20130101) A61B 5/14532 (20130101) A61B 5/14542 (20130101) A61B 5/14865 (20130101) Original (OR) Class A61B 17/025 (20130101) A61B 17/88 (20130101) A61B 17/0206 (20130101) A61B 17/0218 (20130101) A61B 17/708 (20130101) A61B 17/1611 (20130101) A61B 17/1757 (20130101) A61B 17/7032 (20130101) A61B 17/7037 (20130101) A61B 17/7077 (20130101) A61B 17/7079 (20130101) A61B 17/7082 (20130101) A61B 17/7083 (20130101) A61B 2017/0256 (20130101) A61B 2017/00473 (20130101) A61B 2017/564 (20130101) A61B 2017/681 (20130101) A61B 2562/04 (20130101) A61B 2562/0209 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/442 (20130101) A61F 2/4455 (20130101) A61F 2/4611 (20130101) A61F 2002/4435 (20130101) A61F 2002/4485 (20130101) A61F 2002/4635 (20130101) A61F 2002/30131 (20130101) A61F 2002/30772 (20130101) A61F 2310/00359 (20130101)
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10736626 — Tissue clip

US 10736626	del Nido et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Pedro J. del Nido (Lexington, Massachusetts); Nikolay V. Vasilyev (Newton, Massachusetts); Franz Freudenthal (La Paz, Bolivia)
ABSTRACT	A tissue clip for adjoining tissues including a body portion, a biasing mechanism interconnecting the body portion to a tissue grasping mechanism, the grasping mechanism having a first condition wherein the grasping mechanism is extending against and away from the body portion and a second condition wherein the grasping mechanism is biased against the body portion. A tissue clip and deployer combination. A method of interconnecting tissue by deploying the tissue clip, puncturing tissue to be interconnected with the tissue clip, and interconnecting the tissue. A method of treating an aneurism by deploying the tissue clip at an aneurism site, closing off the aneurism site with the tissue clip, and treating the aneurism. A method of imaging a surgical procedure with ultrasound by modifying a surface of a metal surgical instrument, and imaging the metal surgical instrument with ultrasound during a surgical procedure.
FILED	Friday, April 08, 2016
APPL NO	15/094083
ART UNIT	3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/08 (20130101) A61B 17/10 (20130101) A61B 17/11 (20130101) A61B 17/068 (20130101) A61B 17/083 (20130101) A61B 17/0644 (20130101) Original (OR) Class A61B 17/0682 (20130101) A61B 17/12022 (20130101) A61B 17/12109 (20130101) A61B 17/12172 (20130101) A61B 2017/00243 (20130101) A61B 2017/1107 (20130101) A61B 2090/3925 (20160201) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2463 (20130101)
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10736684 — Miniature inductive heating device

US 10736684	Juan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Human Resource Development (HRD)
APPLICANT(S)	Eduardo J. Juan (Cabo Rojo, Puerto Rico); Madeline Torres-Lugo (Cabo Rojo, Puerto Rico); Jorge L. Castro-Torres (Las Piedras, Puerto Rico)
ASSIGNEE(S)	University of Puerto Rico (San Juan, Puerto Rico)
INVENTOR(S)	Eduardo J. Juan (Cabo Rojo, Puerto Rico); Madeline Torres-Lugo (Cabo Rojo, Puerto Rico); Jorge L. Castro-Torres (Las Piedras, Puerto Rico)
ABSTRACT	An induction heating coil is positioned inside a tube-like instrument having dimensions similar to current laparoscopic instruments. Magnetic field intensities of up to 15 kA/m at a frequency of 289 kHz are achieved while the instrument is operated at safe temperatures. A cooling agent system maintains a desired temperature inside the instrument and temperatures sensors monitor the temperature of the cooling agent as well as the temperature of the induction heating coil to safely operate the instrument within operating temperatures.
FILED	Friday, February 23, 2018
APPL NO	15/903171
ART UNIT	3754 — Fluid Handling and Dispensing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/082 (20130101) Original (OR) Class A61B 2018/00023 (20130101) A61B 2018/00178 (20130101) A61B 2018/00815 (20130101) A61B 2018/00821 (20130101) A61B 2018/00875 (20130101) A61B 2018/00982 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/06 (20130101) H05B 6/42 (20130101)
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10736777 — Capsulotomy device

US 10736777	Keller
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Centricity Vision, Inc. (Fremont, California)
ASSIGNEE(S)	Centricity Vision, Inc. (Fremont, California)
INVENTOR(S)	Christopher Guild Keller (El Cerrito, California)
ABSTRACT	A surgical device and procedure are provided for smoothly and easily accessing tissue to perform microsurgery, including a capsulotomy of a lens capsule of an eye. The device includes a handpiece with a tip for insertion into an incision in the cornea of the eye. A sliding element is disposed within the handpiece and a suction cup is mounted to the sliding element. The sliding element can be translated to move the suction cup into and out of the handpiece. A compression mechanism associated with the suction cup and the handpiece compresses the suction cup for deployment through the tip of the handpiece. The suction cup can expand inside the anterior chamber into a cutting position on the lens capsule. A cutting element mounted to the suction cup is used to cut a portion of the lens capsule and to remove the portion from the eye. The cutting element may be mounted to a cutting element support structure in a way that prevents heating of the device.
FILED	Saturday, December 29, 2018
APPL NO	16/236346
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/14 (20130101) A61B 18/1402 (20130101) A61B 2018/00291 (20130101) A61B 2018/00321 (20130101) A61B 2018/00601 (20130101) A61B 2018/1407 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0017 (20130101) A61F 9/00754 (20130101) Original (OR) Class
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10736840 — Thermally stable vaccine formulations and microneedles

US 10736840	Mistilis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)	Georgia Tech Research Corporation (Atlanta, Georgia)
INVENTOR(S)	Matthew Joseph Mistilis (Atlanta, Georgia); William Christopher Edens (Atlanta, Georgia); Andreas Sebastian Bommarius (Atlanta, Georgia); Mark Prausnitz (Atlanta, Georgia)
ABSTRACT	Formulations and methods are provided for stabilizing antigens in dry solid vaccines. One aspect relates to dry solid formulations of influenza vaccines including one or more excipients identified as imparting stability to influenza antigens. Another aspect relates to dry solid formulations of measles vaccines including one or more excipients identified as imparting stability to a measles antigen. The formulations may be in a form suitable for reconstitution in a physiologically acceptable liquid vehicle to form an injectable solution or suspension for administration to a patient or in the form of dissolvable microneedles or coated microneedles.
FILED	Wednesday, September 03, 2014
APPL NO	14/916417
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 39/165 (20130101) A61K 2039/70 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16134 (20130101) C12N 2760/16234 (20130101) C12N 2760/16334 (20130101) C12N 2760/18434 (20130101)
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10736848 — Vaccine nanotechnology

US 10736848	Von Andrian et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Ulrich H. Von Andrian (Chestnut Hill, Massachusetts); Omid C. Farokhzad (Chestnut Hill, Massachusetts); Robert S. Langer (Newton, Massachusetts); Tobias Junt (Schorndorf, Germany); Elliott Ashley Moseman (Jamaica Plain, New York); Liangfang Zhang (San Diego, California); Pamela Basto (Somerville, Massachusetts); Matteo Iannacone (Boston, Massachusetts); Frank Alexis (Greenville, South Carolina)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Ulrich H. Von Andrian (Chestnut Hill, Massachusetts); Omid C. Farokhzad (Chestnut Hill, Massachusetts); Robert S. Langer (Newton, Massachusetts); Tobias Junt (Schorndorf, Germany); Elliott Ashley Moseman (Jamaica Plain, New York); Liangfang Zhang (San Diego, California); Pamela Basto (Somerville, Massachusetts); Matteo Iannacone (Boston, Massachusetts); Frank Alexis (Greenville, South Carolina)
ABSTRACT	The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
FILED	Sunday, October 12, 2008
APPL NO	12/681814
ART UNIT	1699 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) Original (OR) Class A61K 39/00 (20130101) A61K 39/0011 (20130101) A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 47/6911 (20170801) A61K 47/6937 (20170801) A61K 2039/60 (20130101) A61K 2039/555 (20130101) A61K 2039/55555 (20130101) Technologies for Adaptation to Climate Change Y02A 50/464 (20180101)
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10736854 — Nanocrystals, compositions, and methods that aid particle transport in mucus

US 10736854	Popov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Alexey Popov (Waltham, Massachusetts); Elizabeth M. Enlow (Waltham, Massachusetts); James Bourassa (Somerville, Massachusetts); Colin R. Gardner (Concord, Massachusetts); Hongming Chen (Belmont, Massachusetts); Laura M. Ensign (Towson, Maryland); Samuel K. Lai (Carrboro, North Carolina); Tao Yu (Baltimore, Maryland); Justin Hanes (Baltimore, Maryland); Ming Yang (Towson, Maryland)
ABSTRACT	Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.
FILED	Thursday, May 10, 2018
APPL NO	15/976736
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/5031 (20130101) Original (OR) Class A61K 9/5089 (20130101) A61K 9/5138 (20130101) A61K 31/12 (20130101) A61K 31/56 (20130101) A61K 31/58 (20130101) A61K 31/341 (20130101) A61K 31/405 (20130101) A61K 31/409 (20130101) A61K 31/496 (20130101) A61K 31/522 (20130101) A61K 31/569 (20130101) A61K 31/573 (20130101) A61K 31/635 (20130101) A61K 31/662 (20130101) A61K 31/675 (20130101) A61K 47/34 (20130101) A61K 49/0089 (20130101)
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10736877 — Tryptamine-based ship inhibitors for the treatment of cancer

US 10736877	Kerr et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Syracuse, New York); SYRACUSE UNIVERSITY (Syracuse, New York)
ASSIGNEE(S)	SYRACUSE UNIVERSITY (Syracuse, New York); THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY of New York (Syracuse, New York)
INVENTOR(S)	William G. Kerr (Syracuse, New York); Sandra Fernandes Denney (Constantia, New York); John D. Chisholm (Fayetteville, New York)
ABSTRACT	The present disclosure provides compositions that inhibit the SH2-containing inositol 5′-phosphatase (SHIP), as well as methods using such compositions for use in treating or ameliorating the effects of a medical condition in a subject.
FILED	Friday, December 30, 2016
APPL NO	15/396272
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4045 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 35/00 (20180101)
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10736880 — Therapeutics for preterm labor management

US 10736880	Refuerzo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); THE METHODIST HOSPITAL (Houston, Texas)
ASSIGNEE(S)	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMS (Austin, Texas); THE METHODIST HOSPITAL (Houston, Texas)
INVENTOR(S)	Jerrie S. Refuerzo (Houston, Texas); Biana Godin (Houston, Texas); Monica Longo (Houston, Texas)
ABSTRACT	Methods and compositions are provided for treating and preventing preterm labor using liposome encapsulated tocolytic agents, such as indomethacin. In certain aspects, targeted liposomes are provided that allow delivery of tocolytic agents directly to the uterus, such as by targeting to the oxytocin receptor.
FILED	Monday, December 19, 2016
APPL NO	16/063312
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 9/1271 (20130101) A61K 31/405 (20130101) Original (OR) Class A61K 38/095 (20190101) A61K 47/62 (20170801) A61K 47/6911 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/00 (20180101) A61P 15/06 (20180101) Peptides C07K 7/16 (20130101)
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10736898 — Positive allosteric modulators of the muscarinic acetylcholine receptor M4

US 10736898	Lindsley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Craig W. Lindsley (Brentwood, Tennessee); P. Jeffrey Conn (Nashville, Tennessee); Darren W. Engers (Brentwood, Tennessee); Julie L. Engers (Brentwood, Tennessee)
ABSTRACT	Disclosed herein are tricyclic compounds, including thieno[2,3-d:4,5-d′]dipyrimidin-4-amine and pyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M₄(mAChR M₄). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
FILED	Wednesday, December 05, 2018
APPL NO	16/210495
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 495/14 (20130101)
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10736906 — Method to enhance tissue regeneration

US 10736906	Zon et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
ASSIGNEE(S)	CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
INVENTOR(S)	Leonard I. Zon (Wellesley, Massachusetts); Trista E. North (Newton Center, Massachusetts); Wolfram Goessling (Chestnut Hill, Massachusetts)
ABSTRACT	The present invention provides for compositions and methods for modulating tissue growth using tissue growth modulators, which are agents that either enhance or inhibit tissue growth as desired by a particular indication by modulating the PG or Wnt signaling pathways, or employing modulators of both PG and Wnt signaling pathways for a synergistic effect or highly selective effect.
FILED	Thursday, June 09, 2016
APPL NO	15/177365
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) A61K 31/201 (20130101) A61K 31/404 (20130101) A61K 31/557 (20130101) A61K 31/558 (20130101) A61K 31/655 (20130101) A61K 31/5575 (20130101) Original (OR) Class A61K 31/5585 (20130101) A61K 33/14 (20130101)
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10736910 — Treatment of autophagy-based disorders and related pharmaceutical compositions, diagnostic and screening assays and kits

US 10736910	Deretic et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S)	STC.UNM (Albuquerque, New Mexico)
INVENTOR(S)	Vojo P. Deretic (Placitas, New Mexico); Eliseo F. Castillo (Albuquerque, New Mexico)
ABSTRACT	In one embodiment, the invention provides a method of treating a subject suffering from a Mycobacterium infection by administering to the subject a therapeutically-effective amount of a degradative autophagy agonist or a secretory autophagy antagonist. In another embodiment, the invention provides a method of treating a subject suffering from one or more diseases selected from the group consisting of a Mycobacterium infection, an inflammatory disorder, an immune disorder, a cancer and a neurodegenerative disorder by administering to the subject a therapeutically-effective amount of a TBK-1 antagonist (e.g. BX795 or amlexanox). Related pharmaceutical compositions, diagnostic and screening assays and kits are also provided.
FILED	Thursday, September 13, 2018
APPL NO	16/130015
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 31/00 (20130101) A61K 31/38 (20130101) A61K 31/57 (20130101) A61K 31/65 (20130101) A61K 31/277 (20130101) A61K 31/381 (20130101) A61K 31/436 (20130101) A61K 31/472 (20130101) A61K 31/473 (20130101) A61K 31/475 (20130101) A61K 31/495 (20130101) A61K 31/506 (20130101) A61K 31/704 (20130101) Original (OR) Class A61K 31/713 (20130101) A61K 31/4184 (20130101) A61K 31/4365 (20130101) A61K 31/4453 (20130101) A61K 31/4535 (20130101) A61K 31/5415 (20130101) A61K 38/00 (20130101) A61K 38/177 (20130101) A61K 38/1793 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/10 (20180101) A61P 11/12 (20180101) A61P 31/04 (20180101) A61P 31/06 (20180101) Peptides C07K 16/28 (20130101) C07K 16/245 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5055 (20130101) G01N 33/5695 (20130101) G01N 33/6842 (20130101) G01N 33/6893 (20130101) G01N 2333/54 (20130101) G01N 2333/545 (20130101) G01N 2333/4703 (20130101) G01N 2333/4719 (20130101) G01N 2333/4724 (20130101) G01N 2333/90212 (20130101) G01N 2500/02 (20130101) G01N 2500/20 (20130101)
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10736911 — Use of a DHODH inhibitor in combination with an inhibitor of pyrimidine salvage

US 10736911	Deans et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Richard Deans (Rocky Mount, North Carolina); Ayse Okesli (Stanford, California); David Morgens (Stanford, California); Chaitan Khosla (Palo Alto, California); Michael C. Bassik (Palo Alto, California)
ABSTRACT	Compounds and methods are provided for the treatment of pathogenic virus infections or cancer. The formulations combine an inhibitor of de novo pyrimidine synthesis, and an inhibitor of a pyrimidine salvage pathway enzyme.
FILED	Thursday, December 22, 2016
APPL NO	16/063113
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/52 (20130101) A61K 31/404 (20130101) A61K 31/404 (20130101) A61K 31/519 (20130101) A61K 31/519 (20130101) A61K 31/4439 (20130101) A61K 31/4439 (20130101) A61K 31/7072 (20130101) Original (OR) Class A61K 31/7072 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 35/00 (20180101)
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10736915 — Nylon-3 co-polymers and synthetic lung surfactant compositions containing same

US 10736915	Gellman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Science Foundation (NSF)
APPLICANT(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin); NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin); NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Samuel H. Gellman (Madison, Wisconsin); Shannon S. Stahl (Madison, Wisconsin); Brendan P. Mowery (San Marcos, California); Annelise Barron (Palo Alto, California); Michelle Dohm (Palos Park, Illinois)
ABSTRACT	Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic proteins that are critical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restricted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-B mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, are prepared by ring-opening polymerization of β-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B. Attachment of an N-terminal octadecanoyl unit to the nylon-3 copolymers affords further improvements by reducing the percent surface area compression to reach low minimum surface tension.
FILED	Monday, February 05, 2018
APPL NO	15/888720
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0082 (20130101) A61K 31/785 (20130101) Original (OR) Class A61K 47/32 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/22 (20130101) Compositions of Macromolecular Compounds C08L 77/02 (20130101)
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10736918 — Method and compositions for cellular immunotherapy

US 10736918	Jensen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Fred Hutchinson Cancer Research Center (Seattle, Washington); Seattle Children's Hospital (Seattle, Washington)
ASSIGNEE(S)	Fred Hutchinson Cancer Research Center (Seattle, Washington); Seattle Children's Hospital (Seattle, Washington)
INVENTOR(S)	Michael C. Jensen (Bainbridge Island, Washington); Stanley R. Riddell (Sammamish, Washington); Michael Hudecek (Leipzig, Germany)
ABSTRACT	The present invention provides nucleic acids, vectors, host cells, methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring CD8+ central memory T cells or combinations of central memory T cells with CD4+ T cells that are genetically modified to express a chimeric receptor. In embodiments the genetically modified host cell comprises a nucleic acid comprising a polynucleotide coding for a ligand binding domain, a polynucleotide comprising a customized spacer region, a polynucleotide comprising a transmembrane domain, and a polynucleotide comprising an intracellular signaling domain. It has been surprisingly found that the length of the spacer region can affects the ability of chimeric receptor modified T cells to recognize target cells in vitro and affects in vivo efficacy of the chimeric receptor modified T cells. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.
FILED	Friday, November 17, 2017
APPL NO	15/817002
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 14/7151 (20130101) C07K 14/70521 (20130101) C07K 16/32 (20130101) C07K 16/40 (20130101) C07K 16/2803 (20130101) C07K 2317/64 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) C07K 2319/70 (20130101)
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10736922 — High telomerase activity bone marrow mesenchymal stem cells, methods of producing the same and pharmaceuticals and treatment methods based thereon

US 10736922	Shi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S)	University of Southern California (Los Angeles, California)
INVENTOR(S)	Songtao Shi (Thousand Oaks, California); Kentaro Akiyama (Okayama, Japan); Chider Chen (Phildelphia, Pennsylvania)
ABSTRACT	Disclosed are isolated human bone marrow mesenchymal stem cells having high telomerase activity (tBMMSCs). Also disclosed are isolated human CD34+ bone marrow mesenchymal stem cells. Also disclosed are bone marrow mesenchymal stem cells treated with a telomerase induction agent.
FILED	Monday, December 18, 2017
APPL NO	15/845718
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/60 (20130101) A61K 31/60 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 2035/122 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) C12N 2501/02 (20130101)
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10736932 — Small molecule Ras inhibitors

US 10736932	Briesewitz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Roger Briesewitz (Columbus, Ohio); Dehua Pei (Columbus, Ohio); Punit Upadhyaya (Columbus, Ohio); Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)	Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S)	Roger Briesewitz (Columbus, Ohio); Dehua Pei (Columbus, Ohio); Punit Upadhyaya (Columbus, Ohio)
ABSTRACT	Disclosed herein are novel compounds that are Ras inhibitors. Also disclosed are compositions comprising the compounds and methods of using the compounds in treating various diseases. In another aspect, provided is an antibody-drug-conjugate comprising an antibody conjugated with a compound described herein. In still another aspect, provided is a pharmaceutical composition comprising a compound or antibody-drug-conjugate described herein. In a further aspect, provided is method of treating a cancer comprising administering a therapeutically effective amount of a compound or antibody-drug-conjugate described herein to a patient in need thereof.
FILED	Tuesday, May 19, 2015
APPL NO	15/312593
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/01 (20130101) A61K 38/00 (20130101) A61K 38/012 (20130101) Original (OR) Class A61K 38/12 (20130101) A61K 39/3955 (20130101) A61K 47/6811 (20170801) A61K 47/6849 (20170801) A61K 2039/585 (20130101) A61K 2039/627 (20130101) A61K 2300/00 (20130101) Peptides C07K 7/64 (20130101) C07K 14/4703 (20130101) C07K 16/2863 (20130101)
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10736935 — Saposin-A derived peptides and uses thereof

US 10736935	Watnick
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
INVENTOR(S)	Randolph S. Watnick (Newton, Massachusetts)
ABSTRACT	Disclosed herein are polypeptides and fusion polypeptides that have anti-angiogenic activity that can be used to inhibit tumor growth and tumor metastasis. The polypeptide consists of 9 or less consecutive amino acid residues (e.g., 8, 7, 6, 5, or 4) comprising the active core amino acid sequence DWLP, or an amino acid substitution variant thereof. Specific amino acid substitutions are disclosed herein. In some embodiments, the peptide consists essentially of 4-6 mers identified as exhibiting the activity of prosaposin A. Also disclosed herein are therapeutic compositions comprising the polypeptides and fusion polypeptides, and their use in the treatment, prevention, and inhibition of angiogenesis-related diseases and disorders such as cancer and cancer metastasis.
FILED	Friday, December 21, 2012
APPL NO	14/367577
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/07 (20130101) A61K 38/08 (20130101) Original (OR) Class A61K 39/39591 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 5/1019 (20130101) C07K 5/1021 (20130101) C07K 7/06 (20130101) C07K 14/475 (20130101) C07K 16/00 (20130101) C07K 2319/30 (20130101) C07K 2319/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 33/574 (20130101) G01N 33/5023 (20130101) G01N 33/6893 (20130101) G01N 2800/52 (20130101)
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10736943 — Silk microspheres for encapsulation and controlled release

US 10736943	Kaplan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	TRUSTEES OF TUFTS COLLEGE (Medford, Massachusetts)
ASSIGNEE(S)	Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S)	David L. Kaplan (Concord, Massachusetts); Xiaoqin Wang (Winchester, Massachusetts)
ABSTRACT	A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in β-sheet structure dominant silk microsphere structures having about 2 μm in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.
FILED	Tuesday, May 07, 2013
APPL NO	13/888605
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) A61K 9/19 (20130101) A61K 9/127 (20130101) A61K 9/1658 (20130101) A61K 9/5052 (20130101) A61K 31/7076 (20130101) A61K 38/44 (20130101) Original (OR) Class A61K 47/34 (20130101) A61K 47/42 (20130101)
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10736945 — Systemic gene replacement therapy for treatment of X-linked myotubular myopathy (XLMTM)

US 10736945	Childers et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Wake Forest University Health Sciences (Winston-Salem, North Carolina); Genethon (Evry, France); Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	Wake Forest University Health Sciences (Winston-Salem, North Carolina); Genethon (Evry, France); Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Martin K. Childers (Seattle, Washington); Alan H. Beggs (Needham, Massachusetts); Ana Maria Buj Bello (Paris, France)
ABSTRACT	The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces the increased expression of myotubularin in the muscle of a subject. The invention provides sustained regional and global increases in muscle function.
FILED	Thursday, December 28, 2017
APPL NO	15/856653
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Original (OR) Class A61K 48/005 (20130101) A61K 48/0058 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/16 (20130101) C12N 2750/14143 (20130101) Enzymes C12Y 301/03 (20130101) C12Y 301/03064 (20130101)
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10736949 — Radiohalogenated agents for in situ immune modulated cancer vaccination

US 10736949	Weichert et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Jamey Weichert (Sun Prairie, Wisconsin); Paul M. Sondel (Madison, Wisconsin); Anatoly Pinchuk (Fitchburg, Wisconsin); Zachary Morris (Madison, Wisconsin); Mario Otto (Fitchburg, Wisconsin); Bryan Bednarz (Madison, Wisconsin)
ABSTRACT	A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein R₁is a radioactive halogen isotope, n is 18 and R₂is —N⁺(CH₃)₃.
FILED	Tuesday, July 18, 2017
APPL NO	15/652400
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/001 (20130101) Original (OR) Class A61K 39/0011 (20130101) A61K 39/39 (20130101) A61K 39/39558 (20130101) A61K 51/041 (20130101) A61K 51/0408 (20130101) A61K 51/0489 (20130101) A61K 2039/53 (20130101) A61K 2039/58 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) A61K 2039/572 (20130101) A61K 2039/585 (20130101) A61K 2039/55511 (20130101) A61K 2039/55533 (20130101)
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10736956 — Influenza virus vaccination regimens

US 10736956	Palese et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS)
APPLICANT(S)	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York)
ASSIGNEE(S)	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York)
INVENTOR(S)	Peter Palese (New York, New York); Adolfo Garcia-Sastre (New York, New York); Florian Krammer (New York, New York)
ABSTRACT	Provided herein are immunization regimens for inducing an immune response (e.g., an antibody response) against influenza virus. In specific aspects, the immunization regimens involve the administration of a chimeric hemagglutinin (HA), a headless HA or another influenza virus stem domain based construct (e.g., the HA stem domain or a fragment thereof) to a subject. In certain aspects, the immunization regimens also involve the administration of an influenza virus neuraminidase immunogen.
FILED	Friday, January 22, 2016
APPL NO	15/545548
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/543 (20130101) A61K 2039/575 (20130101) Peptides C07K 14/005 (20130101) C07K 14/11 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/04 (20130101) C12N 2760/16134 (20130101) C12N 2760/16234 (20130101)
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10736957 — Enhanced immunogenicity of mRNA with co-encoded adjuvant sequences

US 10736957	Chan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Ying Kai Chan (Cambridge, Massachusetts); Jessica Jing-Shiuan Chiang (Somerville, Massachusetts)
ABSTRACT	Described herein are in vitro-transcribed (IVT) RNA molecules comprising, a 5′ cap structure, a coding region encoding an antigen polypeptide, an immunostimulatory RNA sequence, and a poly(A) tail.
FILED	Thursday, October 04, 2018
APPL NO	16/152096
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/51 (20130101) A61K 2039/53 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) C12N 2310/17 (20130101) C12N 2310/3519 (20130101) C12N 2760/16134 (20130101)
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10736962 — Recombinant MVA or MVADELE3L expressing human FLT3L and use thereof as immuno-therapeutic agents against solid tumors

US 10736962	Deng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Memorial Sloan Kettering Cancer Center (New York, New York)
ASSIGNEE(S)	Memorial Sloan Kettering Cancer Center (New York, New York)
INVENTOR(S)	Liang Deng (New York, New York); Stewart Shuman (New York, New York); Jedd Wolchok (New York, New York); Taha Merghoub (New York, New York); Weiyi Wang (New York, New York); Peihong Dai (New York, New York); Ning Yang (New York, New York)
ABSTRACT	The present disclosure relates generally to the fields of oncology, virology and immunotherapy. It concerns poxviruses, specifically the highly attenuated modified vaccinia virus Ankara (MVA), and a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVAΔE3L), each further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L) or GM-CSF. The disclosure relates to use of the foregoing recombinant viruses as cancer immunotherapeutic agents. The foregoing recombinant poxviruses can also be used in combination with immune checkpoint blockade therapy.
FILED	Saturday, February 25, 2017
APPL NO	16/079222
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/768 (20130101) A61K 39/0011 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/505 (20130101) A61K 2039/55522 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/521 (20130101) C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/24032 (20130101) C12N 2710/24121 (20130101) C12N 2710/24132 (20130101) C12N 2710/24143 (20130101)
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10736966 — Brush-poly (glycoamidoamine)-lipids and uses thereof

US 10736966	Dong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Yizhou Dong (Dublin, Ohio); Joseph R. Dorkin (Somerville, Massachusetts); Robert S. Langer (Newton, Massachusetts); Daniel Griffith Anderson (Framingham, Massachusetts)
ABSTRACT	The present disclosure provides brush-poly(glycoamidoamine)-lipids (PGALs) (e.g., polymers of any one of Formulae (I)-(IV)) and methods of preparing the PGALs. A described PGAL may include poly(glycoamidoamine)-derived moieties (e.g., such as which may assist the PGAL and/or a complex of the PGAL and an agent to pass through cell membranes or be taken up by cells. Also provided are compositions including a described PGAL and an agent (e.g., polynucleotide, small molecule, peptide, or protein). The present disclosure also provides methods, kits, and uses that include or involve the PGALs or compositions for delivering an agent to a subject, tissue, or cell and/or for treating and/or preventing in a subject a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases, respiratory diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, genitourinary diseases, and metabolic disorders
FILED	Wednesday, August 12, 2015
APPL NO	14/825127
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1273 (20130101) A61K 38/1816 (20130101) A61K 47/60 (20170801) A61K 47/544 (20170801) A61K 47/554 (20170801) A61K 47/595 (20170801) A61K 47/6915 (20170801) A61K 47/6935 (20170801) A61K 47/48207 (20130101) Original (OR) Class A61K 48/00 (20130101) A61K 48/0041 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/48 (20130101) C08G 69/50 (20130101) C08G 73/00 (20130101) Compositions of Macromolecular Compounds C08L 79/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2320/32 (20130101)
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10736971 — Peptide-based molecules for modulating car expression or accessibility and uses thereof

US 10736971	Excoffon et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Wright State University (Dayton, Ohio)
ASSIGNEE(S)	WRIGHT STATE UNIVERSITY (, Ohio)
INVENTOR(S)	Katherine Julie Diane Ashbourne Excoffon (Dayton, Ohio); Priyanka Sharma (Beavercreek, Ohio)
ABSTRACT	Peptide-based molecules for modulating expression or accessibility to the coxsackievirus and adenovirus receptor (CAR) are disclosed. Cell-permeable peptide-based molecules having a PDZ-decoy domain or PDZ-binding domain are used to modulate the expression or accessibility of CAR molecules, thereby affecting the ability of viral molecules, or molecules containing viral sequences or proteins able to bind CAR, to enter host cells.
FILED	Saturday, July 09, 2016
APPL NO	15/743039
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) A61K 47/62 (20170801) Original (OR) Class Peptides C07K 14/70596 (20130101) C07K 2319/10 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/10311 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/566 (20130101) G01N 2333/075 (20130101)
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10736972 — Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis

US 10736972	Bradbury et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Memorial Sloan Kettering Cancer Center (New York, New York); Cornell University (Ithaca, New York)
ASSIGNEE(S)	Memorial Sloan Kettering Cancer Center (New York, New York); Cornell University (Ithaca, New York)
INVENTOR(S)	Michelle S. Bradbury (New York, New York); Ulrich Wiesner (Ithaca, New York); Michael Overholtzer (New York, New York); Howard Scher (Tenafly, New Jersey); Kai Ma (Ithaca, New York)
ABSTRACT	Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.
FILED	Thursday, May 26, 2016
APPL NO	15/573855
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/22 (20130101) A61K 47/60 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Original (OR) Class
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10736974 — Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy

US 10736974	Pomper et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
INVENTOR(S)	Martin G. Pomper (Baltimore, Maryland); Ronnie C. Mease (Fairfax, Virginia); Sangeeta Ray (Ellicott City, Maryland); Ying Chen (Lutherville-Timonium, Maryland); Xing Yang (Baltimore, Maryland)
ABSTRACT	Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.
FILED	Thursday, October 22, 2015
APPL NO	15/521149
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 41/0057 (20130101) A61K 49/0002 (20130101) A61K 49/0017 (20130101) A61K 49/0019 (20130101) A61K 49/0021 (20130101) A61K 49/0032 (20130101) A61K 49/0041 (20130101) A61K 49/0052 (20130101) A61K 51/0402 (20130101) Original (OR) Class A61K 51/0455 (20130101) Acyclic or Carbocyclic Compounds C07C 271/22 (20130101) C07C 275/16 (20130101) C07C 323/62 (20130101) Heterocyclic Compounds C07D 209/12 (20130101) C07D 213/82 (20130101)
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10736988 — Bone substitute nanocomposites and methods of synthesis using multiphosphorylated peptides

US 10736988	Beniash et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
INVENTOR(S)	Elia Beniash (Mt. Lebanon, Pennsylvania); Charles S. Sfeir (Pittsburgh, Pennsylvania)
ABSTRACT	The invention relates to peptides including DEDE(SSD)_nDEG indicated by SEQ NO. 1, RRRDEDE(SSD)_nDEG indicated by SEQ NO. 2, RRRGDEDE(SSD)_nDEG indicated by SEQ NO. 3, and LKKLKKLDEDE(SSD)nDEG indicated by SEQ NO. 4, wherein n is an integer from 2 to 20. The invention also relates to phosphorylating these peptides at multiple amino acid sites by employing casein kinases. These phosphorylated peptides may be used in various applications such as forming mineralized collagen fibrils and biomimetic composites for use in tissue repair and regeneration.
FILED	Friday, March 09, 2018
APPL NO	15/917047
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) A61L 27/46 (20130101) A61L 27/46 (20130101) A61L 27/48 (20130101) A61L 27/54 (20130101) A61L 27/227 (20130101) Original (OR) Class A61L 2300/25 (20130101) A61L 2300/252 (20130101) A61L 2430/02 (20130101) Peptides C07K 7/08 (20130101) C07K 14/001 (20130101) C07K 14/47 (20130101) Compositions of Macromolecular Compounds C08L 89/06 (20130101)
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10736989 — Methods and compositions for stabilizing the myocardium

US 10736989	Healy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Kevin E. Healy (Moraga, California); Samuel Thomas Wall (Oslo, Norway); Mark Ratcliffe (Piedmont, California); Julius Guccione (El Cerrito, California)
ABSTRACT	The present invention provides materials and methods that can serve as a prosthetic and/or, for tissue engineering applications, as a supporting matrix in the stabilization of an injured or defective myocardial wall in a patient comprising injecting a polymer network at a pre-selected site in the myocardial wall of the patient.
FILED	Tuesday, August 16, 2016
APPL NO	15/238539
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/715 (20130101) A61K 47/32 (20130101) A61K 47/6903 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/16 (20130101) A61L 27/26 (20130101) Original (OR) Class A61L 27/52 (20130101) A61L 27/505 (20130101) A61L 27/3839 (20130101) A61L 2400/06 (20130101) Compositions of Macromolecular Compounds C08L 33/00 (20130101)
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10736992 — Biomolecular patterning of three dimensional tissue scaffolds

US 10736992	Bailey et al.
FUNDED BY	Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Ryan C. Bailey (Urbana, Illinois); Brendan A. Harley (Urbana, Illinois); Teresa A. Martin (Champaign, Illinois); Steven R. Caliari (Urbana, Illinois)
ASSIGNEE(S)	BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Ryan C. Bailey (Urbana, Illinois); Brendan A. Harley (Urbana, Illinois); Teresa A. Martin (Champaign, Illinois); Steven R. Caliari (Urbana, Illinois)
ABSTRACT	The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.
FILED	Monday, February 27, 2012
APPL NO	14/001327
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/32 (20130101) A61K 38/30 (20130101) A61K 38/1858 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/26 (20130101) A61L 27/38 (20130101) Original (OR) Class A61L 27/48 (20130101) A61L 27/48 (20130101) A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 2430/02 (20130101) A61L 2430/06 (20130101) A61L 2430/20 (20130101) A61L 2430/28 (20130101) A61L 2430/30 (20130101) A61L 2430/32 (20130101) A61L 2430/40 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0063 (20130101) Compositions of Macromolecular Compounds C08L 89/06 (20130101) C08L 89/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0654 (20130101) C12N 5/0655 (20130101) C12N 5/0657 (20130101) C12N 5/0658 (20130101) C12N 2533/54 (20130101)
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10737083 — Bioactive components conjugated to dissolvable substrates of microneedle arrays

US 10737083	Falo, Jr. et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Louis D. Falo, Jr. (Wexford, Pennsylvania); Geza Erdos (Wexford, Pennsylvania)
ABSTRACT	Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
FILED	Friday, February 22, 2019
APPL NO	16/283667
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0023 (20130101) A61M 2037/0046 (20130101) A61M 2037/0053 (20130101) A61M 2037/0061 (20130101) A61M 2202/0007 (20130101) A61M 2202/0057 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 39/025 (20130101) B29C 39/123 (20130101) B29C 41/22 (20130101) B29C 41/34 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2001/08 (20130101) B29K 2995/006 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/753 (20130101) B29L 2031/756 (20130101) B29L 2031/7544 (20130101)
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10737095 — Neurostimulator

US 10737095	Burdick et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	California Institute of Technology (Pasadena, California); University of Louisville Research Foundation, Inc. (Louisville, Kentucky); The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	Californina Institute of Technology (Pasadena, California)
INVENTOR(S)	Joel W. Burdick (Pasadena, California); Yu-Chong Tai (Pasadena, California); John F. Naber (Goshen, Kentucky); Robert S. Keynton (Louisville, Kentucky); Victor Reggie Edgerton (Los Angeles, California); Roland R Roy (Playa Vista, California); Yury Gerasimenko (Los Angeles, California); Susan J. Harkema (Louisville, Kentucky); Jonathan Hodes (Louisville, Kentucky); Claudia A. Angeli (Louisville, Kentucky); Mandheerej S. Nandra (Pasadena, California); Thomas Anthony Desautels (Pasadena, California); Steven L. Upchurch (Louisville, Kentucky); Douglas J. Jackson (New Albany, Indiana); Nicholas A. Terrafranca, Jr. (Laguna Niguel, California); Yangsheng Chen (Louisville, Kentucky)
ABSTRACT	Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.
FILED	Thursday, March 29, 2018
APPL NO	15/940473
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/407 (20130101) A61B 5/0492 (20130101) A61B 5/1106 (20130101) A61B 5/4076 (20130101) A61B 5/4836 (20130101) A61B 2505/09 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101) A61N 1/0553 (20130101) A61N 1/3611 (20130101) A61N 1/36003 (20130101) A61N 1/36007 (20130101) A61N 1/36067 (20130101) A61N 1/36082 (20130101) A61N 1/36103 (20130101) Original (OR) Class A61N 1/36107 (20130101) A61N 1/36114 (20130101) A61N 1/36125 (20130101) A61N 1/36139 (20130101)
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10737100 — Scalable stimulation waveform scheduler

US 10737100	Peterson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Naval Information Warfare Center Pacific (NIWCPACIFIC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	Medtronic, Inc. (Minneapolis, Minnesota)
ASSIGNEE(S)	Medtronic, Inc. (Minneapolis, Minnesota)
INVENTOR(S)	Erik J. Peterson (Fridley, Minnesota); Mandla Shongwe (Brooklyn Park, Minnesota)
ABSTRACT	A medical device stores a set of stimulation profiles, wherein each stimulation profile of the set of stimulation profiles is associated with a set of values for stimulation parameters; selects from the set of stimulation profiles, one or more active stimulation profiles; produces, by a stimulation generator, multiple electrical pulses based on the one or more active stimulation profiles; and separately controls parameter values of respective individual pulses of the multiple pulses.
FILED	Tuesday, November 28, 2017
APPL NO	15/824500
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/3615 (20130101) A61N 1/36062 (20170801) A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 1/36082 (20130101) A61N 1/36107 (20130101) A61N 1/36146 (20130101) A61N 1/36175 (20130101) A61N 1/36178 (20130101) A61N 1/36189 (20130101) A61N 1/37247 (20130101) Original (OR) Class
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10737268 — Multi-sheath flow and on-chip terminating electrode for microfluidic direct-blotting

US 10737268	Furtaw et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	LI-COR, Inc. (Lincoln, Nebraska)
ASSIGNEE(S)	LI-COR, INC. (Lincoln, Nebraska)
INVENTOR(S)	Michael D. Furtaw (Lincoln, Nebraska); Donald T. Lamb (Lincoln, Nebraska); Lyle R. Middendorf (Lincoln, Nebraska)
ABSTRACT	Devices and methods are provided for the separation and dispensing of material using a microfluidic separation column connected via an exit channel to one or more sheath flow channels. The flow of separated material through the separation column is at least partially driven by a voltage potential between a first electrode within the separation column and a terminating electrode within at least one of the sheath flow channels. The separation column, exit channel, sheath flow channels, and electrodes are all within a single monolithic chip. The presence of an on-chip terminating electrode allows for separated material to be entrained in the sheath fluids and ejected onto a surface that can be non-conductive. The presence of multiple sheath flows allows for sheath flow fluids to have different compositions from one another, while reducing the occurrence of sheath flow fluids entering the separation column.
FILED	Monday, August 07, 2017
APPL NO	15/670939
ART UNIT	1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/0268 (20130101) B01L 3/5027 (20130101) B01L 3/50273 (20130101) B01L 3/502753 (20130101) Original (OR) Class B01L 3/502776 (20130101) B01L 2200/0631 (20130101) B01L 2200/0636 (20130101) B01L 2300/06 (20130101) B01L 2300/069 (20130101) B01L 2300/0681 (20130101) B01L 2300/0867 (20130101) B01L 2400/0415 (20130101) B01L 2400/0421 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) G01N 27/44739 (20130101) G01N 27/44756 (20130101) G01N 27/44791 (20130101)
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10737270 — Assay wells with hydrogel as a well-contents separator

US 10737270	Linbeck, III et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	Fannin Partners LLC (Houston, Texas)
ASSIGNEE(S)	Fannin Partners, LLC (Houston, Texas)
INVENTOR(S)	Leo Linbeck, III (Houston, Texas); Michael John Heffernan (Katy, Texas); Dev Chatterjee (Saint Louis, Missouri)
ABSTRACT	In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change.
FILED	Monday, November 12, 2018
APPL NO	16/186922
ART UNIT	1799 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2219/00317 (20130101) B01J 2219/00605 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/54 (20130101) B01L 3/527 (20130101) Original (OR) Class B01L 3/50853 (20130101) B01L 2200/12 (20130101) B01L 2200/16 (20130101) B01L 2200/143 (20130101) B01L 2200/185 (20130101) B01L 2200/0647 (20130101) B01L 2300/069 (20130101) B01L 2300/0887 (20130101) B01L 2400/0677 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/483 (20130101)
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10737995 — Nuclear receptor modulators and their use for the treatment and prevention of cancer

US 10737995	Neckers et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Jane B. Neckers (Bethesda, Maryland); Yeong Sang Kim (Gaithersburg, Maryland); Sunmin Lee (Boyds, Maryland); Vineet Kumar (Frederick, Maryland); Sanjay V. Malhotra (Rockville, Maryland)
ABSTRACT	Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein R₁to R₅and X₁to X₅are as described herein, as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including prostate cancers, other nuclear receptor mediated cancers, and other conditions, are also disclosed.
FILED	Tuesday, August 21, 2018
APPL NO	16/107532
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/12 (20130101) A61K 31/275 (20130101) A61K 31/275 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Acyclic or Carbocyclic Compounds C07C 49/80 (20130101) C07C 49/84 (20130101) C07C 49/796 (20130101) Original (OR) Class C07C 49/813 (20130101) C07C 205/45 (20130101) C07C 255/56 (20130101)
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10738061 — Inhibitors of RAD52 recombination protein and methods using same

US 10738061	Mazin
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Mental Health (NIMH)
APPLICANT(S)	Drexel University (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Drexel University (Philadelphia, Pennsylvania)
INVENTOR(S)	Alexander V. Mazin (Philadelphia, Pennsylvania)
ABSTRACT	The present invention includes novel RAD52 inhibitors for preventing or treating cancers in a subject in need thereof. The present invention further includes a method of preventing or treating cancers in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In certain embodiments, the subject is further administered at least one additional therapeutic agent.
FILED	Wednesday, August 21, 2019
APPL NO	16/547184
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/47 (20130101) A61K 31/55 (20130101) A61K 31/496 (20130101) A61K 31/496 (20130101) A61K 31/517 (20130101) A61K 31/517 (20130101) A61K 31/4188 (20130101) A61K 31/4188 (20130101) A61K 31/4525 (20130101) A61K 31/4741 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 215/38 (20130101) C07D 239/95 (20130101) C07D 307/82 (20130101) C07D 405/12 (20130101) C07D 471/04 (20130101) C07D 491/048 (20130101) C07D 491/056 (20130101) C07D 495/04 (20130101) Original (OR) Class
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10738079 — Compositions and methods for managing respiratory conditions

US 10738079	Koval et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Emory University (Atlanta, Georgia)
ASSIGNEE(S)	Emory University (Atlanta, Georgia)
INVENTOR(S)	Michael Koval (Atlanta, Georgia); Barbara Schlingmann (Decatur, Georgia)
ABSTRACT	This disclosure relates to compositions for use in managing respiratory distress and related disorders. In certain embodiments, the disclosure relates to methods of treating or preventing respiratory distress comprising administering an effective amount of a pharmaceutical composition comprising peptides or agents disclosed herein to a subject in need thereof. In certain embodiments, the peptides or agents decrease the concentration of claudin-5 in cells and tissues of the lungs.
FILED	Friday, April 13, 2018
APPL NO	15/953133
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/166 (20130101) A61K 31/166 (20130101) A61K 31/7088 (20130101) A61K 31/7088 (20130101) A61K 38/08 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class
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10738080 — Inhibitors of beta integrin-G protein alpha subunit binding interactions

US 10738080	Du
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Xiaoping Du (Willowbrook, Illinois)
ABSTRACT	Provided herein are compounds that inhibit a binding interaction between a β integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation.
FILED	Tuesday, May 22, 2018
APPL NO	15/986470
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 47/6909 (20170801) A61K 2039/505 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 14/4722 (20130101) C07K 14/70546 (20130101) C07K 14/70557 (20130101)
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10738095 — Engineered CCL20 locked dimer polypeptide

US 10738095	Volkman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE MEDICAL COLLEGE OF WISCONSIN, INC. (Milwaukee, Wisconsin)
ASSIGNEE(S)	The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin)
INVENTOR(S)	Brian F. Volkman (Muskego, Wisconsin); Anthony E. Getschman (Wauwatosa, Wisconsin); Sam T. Hwang (Brookfield, Wisconsin); Yasutomo Imai (Milwaukee, Wisconsin); Francis C. Peterson (Racine, Wisconsin)
ABSTRACT	The present invention provides a CCL20 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of psoriasis, inflammatory disorders and autoimmune disease.
FILED	Tuesday, May 31, 2016
APPL NO	15/579114
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/521 (20130101) Original (OR) Class
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10738099 — Method of redirecting T cells to treat HIV infection

US 10738099	Riley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	James L. Riley (Downingtown, Pennsylvania); Rachel Leibman (Philadelphia, Pennsylvania); Aimee S. Payne (Merion Station, Pennsylvania); Christoph T. Ellebrecht (Philadelphia, Pennsylvania); Michael C. Milone (Cherry Hill, New Jersey)
ABSTRACT	The present invention relates to compositions and methods for treating of a HIV infected mammal using a CD4 membrane-bound chimeric receptor or a HIV specific scFvs CARs. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with HIV infection.
FILED	Thursday, September 22, 2016
APPL NO	15/761563
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/1774 (20130101) A61K 39/42 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2039/572 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70514 (20130101) Original (OR) Class C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/1045 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) C07K 2319/33 (20130101)
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10738104 — Antibodies against F glycoprotein of Hendra and Nipah viruses

US 10738104	Chan et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S)	Yee-Peng Chan (Bethesda, Maryland); Christopher C. Broder (Silver Spring, Maryland)
ABSTRACT	The present invention relates to antibodies or antibody fragments that bind, neutralize, and/or inhibit Hendra or Nipah virus. The invention provides antibodies or antibody fragments that selectively bind to the F glycoprotein of Hendra or Nipah virus, and pharmaceutical compositions including such antibodies and/or fragments. The invention further provides polynucleotides encoding the antibodies and fragments of the invention and host cells transformed therewith. Additionally, the invention discloses prophylactic, therapeutic, and diagnostic methods employing the antibodies, fragments, polynucleotides, and/or compositions of the invention.
FILED	Thursday, April 12, 2018
APPL NO	15/951327
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/1027 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/51 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/569 (20130101)
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10738116 — Dual specific anti-CD22-anti-CD19 chimeric antigen receptors

US 10738116	Fry et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Terry J. Fry (Bethesda, Maryland); Crystal L. Mackall (Stanford, California); Rimas J. Orentas (Washington, District of Columbia); Waleed Haso (Boston, Massachusetts); Haiying Qin (Potomac, Maryland)
ABSTRACT	The invention provides dual specific chimeric antigen receptors (CARs) having antigenic specificity for CD19 and CD22. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
FILED	Friday, March 18, 2016
APPL NO	15/559485
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/53 (20130101) C07K 2317/56 (20130101) C07K 2317/73 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101)
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10738121 — Therapeutic use of integrin-binding antibodies

US 10738121	Arnaout
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	M. Amin Arnaout (Chestnut Hill, Massachusetts)
ABSTRACT	This disclosure relates to therapeutic use of integrin-binding antibodies.
FILED	Monday, February 29, 2016
APPL NO	15/553925
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Peptides C07K 16/2845 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101)
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10738152 — Methods of electrospinning and compositions made therefrom

US 10738152	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	Univeristy of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Yadong Wang (Allison Park, Pennsylvania); Eric M. Jeffries (Pittsburgh, Pennsylvania); Robert A. Allen (Pittsburgh, Pennsylvania)
ABSTRACT	Disclosed herein are methods of electrospinning poly(glycerol sebacate) (PGS) which allow stable PGS fibers and fibrous PGS constructs, scaffolds and grafts to be formed. In one example, a disclosed method includes generating PGS fibers by blending PGS prepolymer with a heat resistant synthetic carrier polymer, wherein the blend is electrospun into micro- or nano-fibers, and the PGS prepolymer is cross-linked into PGS with heat without using chemical cross-linkers. In another example, a disclosed method includes electrospinning a PGS and gelatin blend, wherein the PGS and gelatin composition are cross-linked by heat curing without using chemical cross-linkers. In another example, the method includes preparing an electrospinning precursor solution comprising blending PGS prepolymer with poly(lactic-co-glycolic acid) (PLGA) and a chemical cross-linker; electrospinning the prepared blend; and exposing the electrospun blend to an organic solvent to remove the PLGA.
FILED	Monday, February 26, 2018
APPL NO	15/904863
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/82 (20130101) A61F 2230/0069 (20130101) A61F 2250/0067 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 47/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/916 (20130101) Original (OR) Class Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) D01D 5/0007 (20130101) D01D 5/0038 (20130101) D01D 10/02 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/62 (20130101)
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10738282 — Use of phospholipid scramblase inhibitors for modulating inflammatory immune responses

US 10738282	Nimmerjahn et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Salk Institute for Biological Studies (La Jolla, California)
ASSIGNEE(S)	Salk Institute for Biological Studies (La Jolla, California)
INVENTOR(S)	Axel Nimmerjahn (San Diego, California); Charles L. Clark (Santee, California)
ABSTRACT	The finding that phosphatidylserine (PtdSer) exposure on the outer leaflet of virally transduced cells triggers their engulfment by resident immune cells is described. It is demonstrated that inhibition of phospholipid scramblase 1 (PLSCR1) activity prevents PtdSer externalization and enables prolonged protection of vector-transduced cells from phagocytosis. Methods of inhibiting a virus vector-induced inflammatory response in tissue, methods of prolonging virus vector encoded transgene expression, and methods of modulating an inflammatory response in tissue of a subject, by administering an inhibitor of PLSCR1 are described.
FILED	Wednesday, December 20, 2017
APPL NO	15/849069
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 38/46 (20130101) A61K 48/0008 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/122 (20130101) C12N 2310/531 (20130101) C12N 2320/31 (20130101) C12N 2710/10041 (20130101) C12N 2710/10043 (20130101) C12N 2710/10071 (20130101) C12N 2710/10343 (20130101) C12N 2710/16641 (20130101) C12N 2710/16643 (20130101) C12N 2710/16671 (20130101) Enzymes C12Y 306/00 (20130101)
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10738284 — B4GALT1 cDNA variants and compositions comprising the same

US 10738284	Montasser et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Regeneron Pharmaceuticals, Inc. (Tarrytown, New York); University of Maryland, Baltimore (Baltimore, Maryland)
ASSIGNEE(S)	Regeneron Pharmaceuticals, Inc. (Tarrytown, New York); University of Maryland, Baltimore (Baltimore, Maryland)
INVENTOR(S)	May Montasser (Baltimore, Maryland); Cristopher Van Hout (Tarrytown, New York); Alan Shuldiner (Tarrytown, New York); Giusy Della Gatta (Tarrytown, New York); Matthew Healy (Tarrytown, New York); Marja Puurunen (Tarrytown, New York)
ABSTRACT	Variant B4GALT1 genomic, mRNA, and cDNA nucleic acid molecules, and polypeptides, methods of detecting the presence of these molecules, methods of modulating endogenous B4GALT1 genomic, mRNA, and cDNA nucleic acid molecules, and polypeptides, methods of ascertaining the risk of developing cardiovascular conditions by detecting the presence or absence of the variant B4GALT1 genomic, mRNA, and cDNA nucleic acid molecules, and polypeptides, and methods of treating cardiovascular conditions are provided herein.
FILED	Monday, June 04, 2018
APPL NO	15/996892
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1051 (20130101) Original (OR) Class C12N 15/86 (20130101) Enzymes C12Y 204/01133 (20130101)
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10738298 — Apparatuses, methods and systems for automated processing of nucleic acids and electrophoretic sample preparation

US 10738298	Abrams et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	SAGE SCIENCE, INC. (Beverly, Massachusetts)
ASSIGNEE(S)	SAGE SCIENCE, INC. (Beverly, Massachusetts)
INVENTOR(S)	Ezra S. Abrams (Newton, Massachusetts); Danny Yun (S. Hamilton, Massachusetts); Todd J. Barbera (Marblehead, Massachusetts); Douglas Grosvenor Sabin (Marblehead, Massachusetts); T. Christian Boles (Bedford, Massachusetts)
ABSTRACT	Methods, systems and apparatus for automated extraction, purification, and processing of nucleic acids from biological samples are presented. In some embodiments, hydrogel supports are used to immobilize particulate biological input samples and extract nucleic acids during operations. The use of hydrogel facilitates automated sample processing on robotic liquid handling systems. Devices, methods, and systems are also provided for electrophoretic sample preparation.
FILED	Thursday, November 15, 2018
APPL NO	16/192520
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 47/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/101 (20130101) Original (OR) Class C12N 15/1017 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44747 (20130101) G01N 27/44756 (20130101) G01N 27/44773 (20130101) G01N 27/44782 (20130101)
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10738300 — Compositions and methods for multiplexed quantitative analysis of cell lineages

US 10738300	Winslow et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Monte M. Winslow (Stanford, California); Dmitri Petrov (Stanford, California); Ian P. Winters (Stanford, California); Christopher McFarland (Stanford, California); Zoe N. Rogers (Menlo Park, California)
ABSTRACT	Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells).
FILED	Tuesday, August 06, 2019
APPL NO	16/533241
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101)
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10738303 — Comprehensive in vitro reporting of cleavage events by sequencing (CIRCLE-seq)

US 10738303	Joung et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	J. Keith Joung (Winchester, Massachusetts); Shengdar Tsai (Memphis, Tennessee)
ABSTRACT	Sensitive, unbiased methods for genome-wide detection of potential CRISPR-Cas9 off-target cleavage sites from cell type-specific genomic DNA samples.
FILED	Friday, December 22, 2017
APPL NO	15/853275
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1031 (20130101) C12N 15/1093 (20130101) Original (OR) Class C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6855 (20130101) C12Q 1/6869 (20130101) C12Q 2525/191 (20130101) C12Q 2535/122 (20130101)
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10738310 — Treating cancer deficient in FANCA, FANCD2, FANCE, or FANCG with an ATM inhibitor

US 10738310	D'Andrea et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Oregon Health Sciences University (Portland, Oregon); The DNA Repair Company (Boston, Massachusetts)
ASSIGNEE(S)	Dana-Faber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S)	Alan D'Andrea (Winchester, Massachusetts); David T. Weaver (Newton, Massachusetts); Markus Grompe (Portland, Oregon); Richard Kennedy (Belfast, Ireland)
ABSTRACT	This present invention compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound.
FILED	Monday, November 23, 2015
APPL NO	14/948914
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2320/30 (20130101) C12N 2320/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57496 (20130101) G01N 2333/4716 (20130101)
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10738312 — Chimeric antigen receptors targeting B-cell maturation antigen

US 10738312	Kochenderfer
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America,as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	James N. Kochenderfer (Bethesda, Maryland)
ABSTRACT	The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
FILED	Thursday, November 14, 2019
APPL NO	16/683435
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2878 (20130101) C07K 2317/73 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class
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10738313 — Chimeric antigen receptors targeting B-cell maturation antigen

US 10738313	Kochenderfer
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	James N. Kochenderfer (Bethesda, Maryland)
ABSTRACT	The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
FILED	Thursday, November 14, 2019
APPL NO	16/683453
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2878 (20130101) C07K 2317/73 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class
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10738343 — Extracellular vesicle ribonucleic acid (RNA) cargo as a biomarker of hyperglycemia and type 1 diabetes

US 10738343	Mirmira et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Trustees of Indiana University (Indianapolis, Indiana); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana)
INVENTOR(S)	Raghavendra G. Mirmira (Zionsville, Indiana); Carmella Evans-Molina (Zionsville, Indiana); Emily K. Sims (Carmel, Indiana)
ABSTRACT	Methods and compositions are provided for detecting and/or determining a patient's risk of developing hyperglycemia or type 1 diabetes. The methods are directed to analyzing the miRNA content of extracellular vesicles recovered from said patient.
FILED	Thursday, January 17, 2019
APPL NO	16/250466
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/06 (20130101) Original (OR) Class C12Q 1/54 (20130101) C12Q 1/686 (20130101) C12Q 1/6883 (20130101) C12Q 2600/112 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/49 (20130101) G01N 2800/042 (20130101)
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10738349 — Polynucleotide based movement, kits and methods related thereto

US 10738349	Salaita et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Emory University (Atlanta, Georgia)
ASSIGNEE(S)	Emory University (Atlanta, Georgia)
INVENTOR(S)	Khalid Salaita (Atlanta, Georgia); Kevin Yehl (Atlanta, Georgia)
ABSTRACT	This disclosure relates DNA based movement of objects. In certain embodiments, particles, pairs of particles, or a rods are conjugated with single stranded DNA that hybridizes to a single stranded RNA that is conjugated to a substrate. When the DNA particle, pair of particles, or rod interacts with the surface RNA in the presence of an endonuclease, such as RNase H and the DNA hybridizes to the RNA, then the particle, pair of particle, or rod moves along the surface. The complementarity of the DNA and RNA affect the velocity.
FILED	Monday, October 24, 2016
APPL NO	15/332007
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6825 (20130101) C12Q 1/6827 (20130101) Original (OR) Class C12Q 2521/327 (20130101) C12Q 2525/121 (20130101) C12Q 2563/149 (20130101) C12Q 2565/107 (20130101) C12Q 2565/131 (20130101) Enzymes C12Y 301/26004 (20130101)
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10738351 — Enrichment of nucleic acid targets

US 10738351	Marziali et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	Quantum-Si Incorporated (Guilford, Connecticut)
ASSIGNEE(S)	Quantum-Si Incorporated (Guilford, Connecticut)
INVENTOR(S)	Andrea Marziali (North Vancouver, Canada); Milenko Despotovic (Richmond, Canada); Joel Pel (Vancouver, Canada)
ABSTRACT	Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.
FILED	Wednesday, April 24, 2019
APPL NO	16/393814
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 2200/0631 (20130101) B01L 2300/1805 (20130101) B01L 2400/0421 (20130101) B01L 2400/0451 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 5/026 (20130101) B03C 2201/18 (20130101) B03C 2201/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/101 (20130101) C12N 15/101 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6832 (20130101) Original (OR) Class C12Q 1/6837 (20130101) C12Q 2527/101 (20130101) C12Q 2563/107 (20130101) C12Q 2565/125 (20130101)
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10738357 — Transportation of native chromatin for personal epigenomics

US 10738357	Giresi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Paul Giresi (Palo Alto, California); Jason D. Buenrostro (Redwood City, California); Howard Y. Chang (Stanford, California); William J. Greenleaf (Menlo Park, California)
ABSTRACT	Provided herein is a method for analyzing polynucleotides such as genomic DNA. In certain embodiments, the method comprises: (a) treating chromatin isolated from a population of cells with an insertional enzyme complex to produce tagged fragments of genomic DNA; (b) sequencing a portion of the tagged fragments to produce a plurality of sequence reads; and (c) making an epigenetic map of a region of the genome of the cells by mapping information obtained from the sequence reads to the region. A kit for performing the method is also provided.
FILED	Tuesday, May 21, 2019
APPL NO	16/418796
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2521/301 (20130101) C12Q 2521/301 (20130101) C12Q 2521/301 (20130101) C12Q 2521/507 (20130101) C12Q 2525/191 (20130101) C12Q 2535/122 (20130101) C12Q 2537/164 (20130101) C12Q 2537/164 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 30/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101)
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10738362 — Determining prostate cancer recurrence using polymorphisms in angiogenesis-related genes

US 10738362	Park et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida)
ASSIGNEE(S)	H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida)
INVENTOR(S)	Jong Park (Tampa, Florida); Thomas Sellers (Tampa, Florida); Julio M. Powsang (Tampa, Florida); Hui-Yi Lin (Tampa, Florida)
ABSTRACT	In particular, disclosed is a method for treating a patient with prostate cancer that involves genotyping a nucleic acid sample from the subject for one or more single nucleotide polymorphism (SNP) alleles in one or more genes angiogenesis, comparing the one or more SNP alleles to control allele frequencies to produce a SNP signature, and analyzing the SNP signature to generate a risk score. The risk score can represent the likelihood that the patient's prostate cancer will recur following radical prostatectomy. In particular embodiments, a high risk score in a patient with positive margins is an indication of a high risk of prostate cancer recurrence.
FILED	Thursday, October 13, 2016
APPL NO	15/292742
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101)
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10738365 — Real-time PCR point mutation assays for detecting HIV-1 resistance to antiviral drugs

US 10738365	Johnson et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, Maryland)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Rockville, Maryland)
INVENTOR(S)	Jeffrey A. Johnson (Stone Mountain, Georgia); Walid M. Heneine (Atlanta, Georgia); Jonathan T. Lipscomb (Decatur, Georgia); Xierong Wei (Johns Creek, Georgia)
ABSTRACT	Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase, protease, or integrase of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID NOS: 1-89, 96-122, and 124-151. Also provided are the oligonucleotides consisting of the nucleotides as set forth in SEQ ID NOS: 1-89, 96-122, and 124-151. Each of the disclosed oligonucleotides is a probe or a primer. Also provided are mixtures of primers and probes and for use in RT-PCR and primary PCR reactions disclosed herein. Provided are methods for the specific detection of several mutations in HIV simultaneously or sequentially. Mutations in the reverse transcriptase, protease, or integrase of HIV can be detected using the methods described herein.
FILED	Monday, June 02, 2014
APPL NO	14/894737
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/703 (20130101) Original (OR) Class C12Q 2600/156 (20130101)
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10739331 — OMA1 activity assay

US 10739331	MacMillan-Crow
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	BioVentures, LLC (Little Rock, Arkansas)
ASSIGNEE(S)	BioVentures, LLC (Little Rock, Arkansas)
INVENTOR(S)	Lee Ann MacMillan-Crow (Little Rock, Arkansas)
ABSTRACT	The present disclosure relates to methods and compositions for detecting mitochondrial dysfunction. In particular, the disclosure relates to reporter molecules that are cleavable by the zinc metalloprotease Metalloendopeptidase OMA1 (OMA1). In each embodiment, the reporter molecules of the invention are particularly useful for drug discovery and detection of diseases associated with mitochondrial dysfunction.
FILED	Friday, August 10, 2018
APPL NO	16/101134
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/705 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/07 (20130101) C07K 2319/33 (20130101) C07K 2319/50 (20130101) C07K 2319/60 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6416 (20130101) C12N 9/6489 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) G01N 33/582 (20130101) G01N 33/5008 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 2333/705 (20130101) G01N 2333/96419 (20130101) G01N 2800/7066 (20130101)
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10739344 — Zinc finger linker (ZnFL) antibody

US 10739344	Ivanov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Center for Research Resources (NCRR) National Institute of General Medical Sciences (NIGMS) IDeA Networks of Biomedical Research Excellence (INBRE)
APPLICANT(S)	West Virginia University (Morgantown, West Virginia)
ASSIGNEE(S)	West Virginia University (Morgantown, West Virginia)
INVENTOR(S)	Alexey Ivanov (Morgantown, West Virginia); Joseph Addison (Morgantown, West Virginia)
ABSTRACT	The present invention provides a purified antibody that recognizes the conserved zinc fingers linker region (ZnFL) in multiple KRAB-ZNF. The purified antibody recognizes at least one of a conserved zinc finger linker sequence of TGEKPY (SEQ ID NO: 1), TGEKPYK (SEQ ID NO: 2), and TGEKPYE (SEQ ID NO: 3). A method of treating a patient having cancer comprising administering an effective amount of a purified antibody recognizing at least one of a conserved zinc finger linker sequence of TGEKPY (SEQ ID NO: 1), TGEKPYK (SEQ ID NO: 2), and TGEKPYE (SEQ ID NO: 3) is set forth. A diagnostic kit and an affinity matrix detecting one of these conserved zinc finger linker sequences are disclosed. A method of detecting cancerous cells comprising subjecting a cancerous cell to a purified pan-ZNF specific antibody is provided. An antigen is provided that binds to a purified zinc finger linker antibody sequence selected from the group consisting of: SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO: 7, SEQ ID NO:8, and SEQ ID NO:9.
FILED	Monday, December 28, 2015
APPL NO	14/979733
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/18 (20130101) C07K 2317/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) Original (OR) Class G01N 33/57496 (20130101) G01N 2333/4703 (20130101)
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10739349 — Chromophoric polymer dots

US 10739349	Chiu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	University of Washington through its Center for Commercialization (Seattle, Washington)
ASSIGNEE(S)	University of Washington through its Center for Commercialization (Seattle, Washington)
INVENTOR(S)	Daniel T. Chiu (Seattle, Washington); Changfeng Wu (Seattle, Washington); Xuanjun Zhang (Linköping, Sweden); Jiangbo Yu (Seattle, Washington); Fangmao Ye (Seattle, Washington)
ABSTRACT	The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
FILED	Friday, May 27, 2016
APPL NO	15/167513
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) B82Y 30/00 (20130101) B82Y 40/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) C08G 2261/12 (20130101) C08G 2261/54 (20130101) C08G 2261/72 (20130101) C08G 2261/94 (20130101) C08G 2261/228 (20130101) C08G 2261/522 (20130101) C08G 2261/1426 (20130101) C08G 2261/3142 (20130101) C08G 2261/3246 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/11 (20130101) C08J 2327/22 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 11/025 (20130101) C09K 2211/1425 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/588 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0039 (20130101)
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10739366 — System and method for screening a library of samples

US 10739366	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland); Pioneer Hi-Bred International, Inc. (Johnston, Iowa)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Tza-huei J. Wang (Timonium, Maryland); Tushar Dnyandeo Rane (Baltimore, Maryland); Helena Claire Zec (Baltimore, Maryland); Wen-Chy Chu (Baltimore, Maryland)
ABSTRACT	A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.
FILED	Friday, January 18, 2019
APPL NO	16/251744
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/0241 (20130101) B01L 3/0265 (20130101) B01L 3/502715 (20130101) B01L 3/502784 (20130101) B01L 2200/14 (20130101) B01L 2200/027 (20130101) B01L 2200/143 (20130101) B01L 2200/147 (20130101) B01L 2200/0673 (20130101) B01L 2300/18 (20130101) B01L 2300/0829 (20130101) B01L 2300/0838 (20130101) B01L 2300/0883 (20130101) B01L 2300/1822 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 60/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 35/08 (20130101) Original (OR) Class G01N 35/00029 (20130101) G01N 35/00871 (20130101) G01N 2035/00148 (20130101)
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10739420 — Motion-robust transmit radio frequency field mapping in magnetic resonance imaging using interleaved bloch-siegert shifting

US 10739420	Weingartner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Sebastian Weingartner (Heidelberg, Germany); Mehmet Akcakaya (Minneapolis, Minnesota)
ABSTRACT	Systems and methods for mapping the transmit sensitivity of one or more radio frequency (“RF”) coils for use in magnetic resonance imaging (“MRI”) are described. The transmit RF field (“B1+”) for an RF coil, or an array of RF coils, is mapped using a robust, motion-insensitive technique that implements Bloch-Siegert shifts performed with interleaved positive and negative off-resonance shifts. The motion insensitivity of this technique makes it particularly useful for applications where there is significant motion, such as cardiac imaging, in which previous B1+ mapping techniques are not as accurate or effective.
FILED	Wednesday, September 06, 2017
APPL NO	15/697184
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0044 (20130101) A61B 5/055 (20130101) A61B 5/7285 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/246 (20130101) Original (OR) Class G01R 33/385 (20130101) G01R 33/482 (20130101) G01R 33/3628 (20130101) G01R 33/56509 (20130101)
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10739427 — Gradient coil with external direct cooling for brain magnetic resonance imaging

US 10739427	Yang et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of the Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	University of Maryland (College Park, Maryland); The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Bao Yang (Ellicott City, Maryland); Hanbing Lu (Ellicott City, Maryland); Zhi Yang (Danbury, Connecticut)
ABSTRACT	The gradient coil assembly is designed to address a neck-shoulder clearance problem by configuring the coil holder housing with a cylindrical portion modified with a slanted surface and positioning current return elements of the coil pattern at the slanted surface, while positioning the active electrical elements on the cylindrical surface, thus eliminating influence of an undesired magnetic field generated by the current return elements, shortening the coil, and moving the homogeneous field gradient region toward the end of the cylindrical portion of the bore in the coil holder housing. The subject assembly operation is further improved by the direct external cooling approach, where a coolant flows in direct contact with electrical wires of the gradient coil inside the cooling channels in the surface of the coil holder housing.
FILED	Friday, January 04, 2019
APPL NO	16/239747
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3856 (20130101) Original (OR) Class G01R 33/3858 (20130101)
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10740880 — Systems and methods for analyzing pathologies utilizing quantitative imaging

US 10740880	Paik et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	ELUCID BIOIMAGING INC. (Boston, Massachusetts)
ASSIGNEE(S)	ELUCID BIOIMAGING INC. (Boston, Massachusetts)
INVENTOR(S)	David S. Paik (Half Moon Bay, California); Andrew J. Buckler (Wenham, Massachusetts); Kjell Johnson (Ann Arbor, Michigan); Xiaonan Ma (South Hamilton, Massachusetts); Keith A. Moulton (Amesbury, Massachusetts)
ABSTRACT	The present disclosure provides for improved image analysis via novel deblurring and segmentation techniques of image data. These techniques advantageously account for and incorporate segmentation of biological analytes into a deblurring process for an image. Thus, the deblurring of the image may advantageously be optimized for enabling identification and quantitative analysis of one or more biological analytes based on underlying biological models for those analytes. The techniques described herein provide for significant improvements in the image deblurring and segmentation process which reduces signal noise and improves the accuracy of the image. In particular, the system and methods described herein advantageously utilize unique optimization and tissue characteristics image models which are informed by the underlying biology being analyzed, (for example by a biological model for the analytes). This provides for targeted deblurring and segmentation which is optimized for the applied image analytics.
FILED	Thursday, January 18, 2018
APPL NO	15/874474
ART UNIT	2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/34 (20130101) G06K 9/621 (20130101) G06K 9/4647 (20130101) G06K 2209/05 (20130101) Image Data Processing or Generation, in General G06T 5/003 (20130101) Original (OR) Class G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 7/136 (20170101) G06T 7/143 (20170101) G06T 7/194 (20170101) G06T 2207/10072 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10132 (20130101) G06T 2207/20036 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20152 (20130101) G06T 2207/20161 (20130101) G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) G06T 2207/30101 (20130101)
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10740884 — System and method for high precision multi-aperture spectral imaging

US 10740884	McCall et al.
FUNDED BY	Department of Defense (DOD) Defense Health Agency (DHA) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA)
APPLICANT(S)	SPECTRAL MD, INC. (Dallas, Texas)
ASSIGNEE(S)	SPECTRAL MD, INC. (Dallas, Texas)
INVENTOR(S)	Brian McCall (Dallas, Texas); Wensheng Fan (Plano, Texas); Jason Dwight (Dallas, Texas); Zhicun Gao (Plano, Texas); Jeffrey E. Thatcher (Irving, Texas); John Michael DiMaio (Dallas, Texas)
ABSTRACT	Generally described, one or more aspects of the present application correspond to systems and techniques for spectral imaging using a multi-aperture system with curved multi-bandpass filters positioned over each aperture. The present disclosure further relates to techniques for implementing spectral unmixing and image registration to generate a spectral datacube using image information received from such imaging systems. Aspects of the present disclosure relate to using such a datacube to analyze the imaged object, for example to analyze tissue in a clinical setting, perform biometric recognition, or perform materials analysis.
FILED	Thursday, January 09, 2020
APPL NO	16/738910
ART UNIT	2481 — Recording and Compression
CURRENT CPC	Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 7/33 (20170101) G06T 7/55 (20170101) G06T 7/62 (20170101) G06T 2207/10036 (20130101) G06T 2207/10144 (20130101) G06T 2207/20221 (20130101) Pictorial Communication, e.g Television H04N 5/265 (20130101) H04N 5/2254 (20130101) H04N 5/2256 (20130101) H04N 5/2356 (20130101)
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10740931 — Method for performing magnetic resonance imaging reconstruction with unsupervised deep learning

US 10740931	Cheng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Joseph Y. Cheng (Los Altos, California); Feiyu Chen (Stanford, California); John M. Pauly (Stanford, California); Shreyas S. Vasanawala (Stanford, California)
ABSTRACT	A method for magnetic resonance imaging performs unsupervised training of a deep neural network of an MRI apparatus using a training set of under-sampled MRI scans, where each scan comprises slices of under-sampled, unclassified k-space MRI measurements. The MRI apparatus performs an under-sampled scan to produce under-sampled k-space data, updates the deep neural network with the under-sampled scan, and processes the under-sampled k-space data by the updated deep neural network of the MRI apparatus to reconstruct a final MRI image.
FILED	Sunday, September 30, 2018
APPL NO	16/147830
ART UNIT	2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/088 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) Original (OR) Class G06T 2210/41 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101)
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10741171 — Kernel-based verbal phrase splitting devices and methods

US 10741171	Master et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	NANTMOBILE, LLC (Culver City, California)
ASSIGNEE(S)	NANTMOBILE, LLC (Culver City, California)
INVENTOR(S)	Demitrios L. Master (Cupertino, California); Farzad Ehsani (Sunnyvale, California)
ABSTRACT	A device capable of splitting user input into phrases is presented. The disclosed device leverages multiple phrase splitting models to generate one or more possible split locations. The possible split locations can be derived based on leveraging multiple phrase splitting models. Each model contributes its suggested split locations to the set of possible split locations according to an implementation of a phrase splitting kernel algorithm that weights each model's suggestions.
FILED	Monday, July 08, 2019
APPL NO	16/505485
ART UNIT	2659 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 40/284 (20200101) G06F 40/289 (20200101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/04 (20130101) Original (OR) Class G10L 15/22 (20130101) G10L 15/197 (20130101)
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10741291 — Systems and methods for genomic annotation and distributed variant interpretation

US 10741291	Torkamani
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
ASSIGNEE(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, Arizona)
INVENTOR(S)	Ali Torkamani (San Diego, California)
ABSTRACT	A computer-based genomic annotation system, including a database configured to store genomic data, non-transitory memory configured to store instructions, and at least one processor coupled with the memory, the processor configured to implement the instructions in order to implement an annotation pipeline and at least one module filtering or analysis of the genomic data.
FILED	Thursday, March 26, 2015
APPL NO	15/128924
ART UNIT	2159 — Data Bases & File Management
CURRENT CPC	Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 50/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 70/60 (20180101) Original (OR) Class
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10743110 — Devices and methods for hearing

US 10743110	Puria et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S)	EARLENS CORPORATION (Menlo Park, California)
ASSIGNEE(S)	Earlens Corporation (Menlo Park, California)
INVENTOR(S)	Sunil Puria (Boston, Massachusetts); Micha Rosen (Tzur Hadassah, Israel); Jonathan P. Fay (Dexter, Michigan); Paul Rucker (San Francisco, California); James Stone (Saratoga, California)
ABSTRACT	A device to transmit an audio signal to a user comprises a transducer and a support. The support is configured for placement on the eardrum to drive the eardrum. The transducer is coupled to the support at a first location to decrease occlusion and a second location to drive the eardrum. The transducer may comprise one or more of an electromagnetic balanced armature transducer, a piezoelectric transducer, a magnetostrictive transducer, a photostrictive transducer, or a coil and magnet. The device may find use with open canal hearing aids.
FILED	Monday, February 06, 2017
APPL NO	15/425684
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 11/02 (20130101) Original (OR) Class H04R 17/00 (20130101) H04R 23/008 (20130101) H04R 25/02 (20130101) H04R 25/65 (20130101) H04R 25/554 (20130101) H04R 25/606 (20130101) H04R 25/652 (20130101) H04R 2225/025 (20130101) H04R 2460/09 (20130101) H04R 2460/13 (20130101)
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Department of Defense (DOD)

10736551 — Epidermal photonic systems and methods

US 10736551	Rogers
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	John A. Rogers (Champaign, Illinois)
ABSTRACT	The invention provides systems and methods for tissue-mounted photonics. Devices of some embodiments implement photonic sensing and actuation in flexible and/stretchable device architectures compatible with achieving long term, mechanically robust conformal integration with a range of tissue classes, including in vivo biometric sensing for internal and external tissues. Tissue-mounted photonic systems of some embodiments include colorimetric, fluorometric and/or spectroscopic photonics sensors provided in pixelated array formats on soft, elastomeric substrates to achieve spatially and/or or temporally resolved sensing of tissue and/or environmental properties, while minimize adverse physical effects to the tissue. Tissue-mounted photonic systems of some embodiments enable flexible passive or active optical sensing modalities, including sensing compatible with optical readout using a mobile electronic devices such as a mobile phone or tablet computer.
FILED	Tuesday, August 11, 2015
APPL NO	15/501364
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/002 (20130101) A61B 5/0022 (20130101) A61B 5/0261 (20130101) A61B 5/0537 (20130101) A61B 5/1451 (20130101) A61B 5/1455 (20130101) Original (OR) Class A61B 5/1468 (20130101) A61B 5/4875 (20130101) A61B 5/14521 (20130101) A61B 5/14532 (20130101) A61B 5/14539 (20130101) A61B 5/14546 (20130101) A61B 10/0041 (20130101) A61B 2560/0214 (20130101) A61B 2560/0223 (20130101) A61B 2560/0242 (20130101) A61B 2562/164 (20130101) A61B 2562/0233 (20130101)
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10736561 — Neural model-based controller

US 10736561	Howard et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Michael D. Howard (Westlake Village, California); Steven W. Skorheim (Canoga Park, California); Praveen K. Pilly (West Hills, California)
ABSTRACT	Described is a system for memory improvement intervention. Based on both real-time EEG data and a neural model, the system simulates replay of a person's specific memory during a sleep state. Using the neural model, a prediction of behavioral performance of the replay of the specific memory is generated. If the prediction is below a first threshold, then using a memory enhancement intervention system, the system applies an intervention during the sleep state to improve consolidation of the specific memory. If the prediction is below a second threshold, the system reduces the intervention performed using the memory enhancement intervention system.
FILED	Friday, January 19, 2018
APPL NO	15/875591
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0482 (20130101) A61B 5/04012 (20130101) A61B 5/4812 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36025 (20130101) A61N 1/36092 (20130101) A61N 1/36139 (20130101)
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10736604 — System and method for assessment of cardiac stroke volume and volume responsiveness

US 10736604	Murthi
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	University of Maryland, Baltimore (Baltimore, Maryland)
ASSIGNEE(S)	University of Maryland, Baltimore (Baltimore, Maryland)
INVENTOR(S)	Sarah B. Murthi (Lutherville, Maryland)
ABSTRACT	Disclosed are systems and methods using ultrasound to predict if a patient's cardiac stroke volume will increase with a fluid bolus. Ultrasound measures are taken before administering a fluid bolus, including measurement of the left ventricular outflow tract velocity time integral (LVOT VTI), and venous measurements of the internal jugular vein. Data collected from such ultrasound scan is then used to predict the patient's cardiac volume response in the event that a fluid bolus is administered to that patient.
FILED	Tuesday, January 17, 2017
APPL NO	15/407380
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 8/065 (20130101) Original (OR) Class A61B 8/461 (20130101) A61B 8/488 (20130101) A61B 8/5223 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2205/3375 (20130101)
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10737100 — Scalable stimulation waveform scheduler

US 10737100	Peterson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Naval Information Warfare Center Pacific (NIWCPACIFIC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	Medtronic, Inc. (Minneapolis, Minnesota)
ASSIGNEE(S)	Medtronic, Inc. (Minneapolis, Minnesota)
INVENTOR(S)	Erik J. Peterson (Fridley, Minnesota); Mandla Shongwe (Brooklyn Park, Minnesota)
ABSTRACT	A medical device stores a set of stimulation profiles, wherein each stimulation profile of the set of stimulation profiles is associated with a set of values for stimulation parameters; selects from the set of stimulation profiles, one or more active stimulation profiles; produces, by a stimulation generator, multiple electrical pulses based on the one or more active stimulation profiles; and separately controls parameter values of respective individual pulses of the multiple pulses.
FILED	Tuesday, November 28, 2017
APPL NO	15/824500
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/3615 (20130101) A61N 1/36062 (20170801) A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 1/36082 (20130101) A61N 1/36107 (20130101) A61N 1/36146 (20130101) A61N 1/36175 (20130101) A61N 1/36178 (20130101) A61N 1/36189 (20130101) A61N 1/37247 (20130101) Original (OR) Class
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10737445 — Filament winding for orientation and spreading on a substrate

US 10737445	Kayhart et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	U.S. Government as Represented by the Secretary of the Army (Natick, Massachusetts)
ASSIGNEE(S)	U.S. Government as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Tony J Kayhart (Natick, Massachusetts); Jason C Parker (Natick, Massachusetts); Nicholas Tsantinis (Natick, Massachusetts); John W Song (Natick, Massachusetts); Damian Kubiak (Natick, Massachusetts)
ABSTRACT	A method, apparatus, and system for winding a filament around a substrate includes mounting the substrate to a rotatable structure and rotating the substrate to wind the first filament around the substrate in a first winding orientation that winds the first filament around a first pair of edges of the substrate to wrap a first filament layer around the substrate. The method further includes changing winding orientations of the first filament from the first winding orientation to a second winding orientation by turning the first filament about a corner of the substrate and winding the first filament around the rotating substrate in the second winding orientation that winds the first filament around a second pair of edges of the substrate, wherein the second pair of edges is different from the first pair of edges, to wrap a second filament layer around the substrate.
FILED	Tuesday, January 30, 2018
APPL NO	15/883379
ART UNIT	3654 — Material and Article Handling
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/32 (20130101) Original (OR) Class B29C 70/34 (20130101) B29C 70/222 (20130101) B29C 70/382 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2623/12 (20130101) B29K 2995/0026 (20130101) Handling Thin or Filamentary Material, e.g Sheets, Webs, Cables B65H 54/10 (20130101) B65H 54/22 (20130101) B65H 2701/313 (20130101)
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10737776 — Apparatus and method for roll moment equalization at high advance ratios for rotary wing aircraft

US 10737776	Sonneborn
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Skyworks Global Inc. (Salt Lake City, Utah)
ASSIGNEE(S)	Skyworks Global Inc. (Salt Lake City, Utah)
INVENTOR(S)	Walter Gerd Oskar Sonneborn (Colleyville, Texas)
ABSTRACT	A method for equalizing rolling moments at high advance ratios is disclosed including impelling an aircraft in a forward direction at an airspeed by means of a thrust source and rotating a rotor of the aircraft at an angular velocity with respect to the airspeed effective to cause a positive total lift on each blade due to air flow over the blades in the retreating direction when the blade is moving in the retreating direction. The rotor includes an even number of blades placed at equal angular intervals around the rotor hub. One or both of cyclic pitch and rotor angle of attack are adjusted such that a rolling moment of the retreating blade due to reverse air flow is between 0.3 and 0.7 times a rolling moment on the advancing blade due to lift.
FILED	Monday, February 26, 2018
APPL NO	15/904726
ART UNIT	3619 — Material and Article Handling
CURRENT CPC	Aeroplanes; Helicopters B64C 27/02 (20130101) B64C 27/18 (20130101) B64C 27/26 (20130101) B64C 27/57 (20130101) B64C 27/615 (20130101) Original (OR) Class B64C 2027/7261 (20130101)
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10738104 — Antibodies against F glycoprotein of Hendra and Nipah viruses

US 10738104	Chan et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S)	Yee-Peng Chan (Bethesda, Maryland); Christopher C. Broder (Silver Spring, Maryland)
ABSTRACT	The present invention relates to antibodies or antibody fragments that bind, neutralize, and/or inhibit Hendra or Nipah virus. The invention provides antibodies or antibody fragments that selectively bind to the F glycoprotein of Hendra or Nipah virus, and pharmaceutical compositions including such antibodies and/or fragments. The invention further provides polynucleotides encoding the antibodies and fragments of the invention and host cells transformed therewith. Additionally, the invention discloses prophylactic, therapeutic, and diagnostic methods employing the antibodies, fragments, polynucleotides, and/or compositions of the invention.
FILED	Thursday, April 12, 2018
APPL NO	15/951327
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/1027 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/51 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/569 (20130101)
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10738387 — Electrochemical cell containing a graphene coated electrode

US 10738387	Botte et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Construction Engineering Research Laboratory (CERL) U.S. Army Corps of Engineers (USACE) Engineer Research and Development Center (ERDC) Construction Engineering Research Laboratory (CERL)
APPLICANT(S)	Ohio University (Athens, Ohio)
ASSIGNEE(S)	Ohio University (Athens, Ohio)
INVENTOR(S)	Gerardine G. Botte (Athens, Ohio); Santosh Vijapur (Beavercreek, Ohio)
ABSTRACT	An electrochemical cell 10 is provided that includes first and second electrodes 13, 15, an electrolyte medium 17 in electrolytic communication with the first and second electrodes 13, 15, a chemical substance capable of undergoing an electrochemical reaction, and a voltage source 19 in electrolytic communication with the first and second electrodes 13, 15. The first electrode 13 includes a layer of an active catalyst material 25, and graphene coating 27 at least partially covering the layer of the active catalyst material 25. Methods for making and using the graphene coated electrode are further provided.
FILED	Monday, October 27, 2014
APPL NO	15/031458
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 32/186 (20170801) Ammonia; Cyanogen; Compounds Thereof C01C 1/086 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/00 (20130101) C25B 3/02 (20130101) C25B 9/06 (20130101) C25B 11/0478 (20130101) Original (OR) Class
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10738636 — Dual wall airfoil with stiffened trailing edge

US 10738636	O'Leary
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Rolls-Royce North American Technologies, Inc. (Indianapolis, Indiana)
ASSIGNEE(S)	Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
INVENTOR(S)	Mark O'Leary (Zionsville, Indiana)
ABSTRACT	An airfoil adapted for use in a gas turbine engine is disclosed herein. The airfoil includes a spar defining an interior space and a cover sheet extending around at least a portion of the spar. The cover sheet is bonded to the spar to define a cooling cavity between the spar and the cover sheet.
FILED	Wednesday, December 14, 2016
APPL NO	15/378915
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/147 (20130101) F01D 5/189 (20130101) F01D 9/065 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/90 (20130101) F05D 2240/122 (20130101) F05D 2250/182 (20130101) F05D 2260/202 (20130101) F05D 2300/6033 (20130101)
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10738692 — Distributed propulsion and electric power generation system

US 10738692	Nolcheff et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
ASSIGNEE(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
INVENTOR(S)	Nick Nolcheff (Chandler, Arizona); John Meier (Phoenix, Arizona); James Laffan (Phoenix, Arizona); Alan D. Hemmingson (Tempe, Arizona); Cristian Anghel (Oro Valley, Arizona); Mike Koerner (Rancho Palos Verdes, California)
ABSTRACT	A propulsion and electric power generation system includes a gas turbine propulsion engine, an electrical generator, an aircraft power distribution system, a plurality of auxiliary fans, and a controller. The gas turbine propulsion engine includes at least a low-pressure turbine coupled to a fan via a low-pressure spool, and the low-pressure turbine is configured to generate mechanical power. The electrical generator is directly connected to the low-pressure spool and generates a total amount of electrical power (Pe). The aircraft power distribution system receives a first fraction (Pa) of the total amount of electrical power. The auxiliary fans receive a second fraction (Pf) of the total amount of electrical power. The controller is configured to control a ratio of Pf to Pa (Pf/Pa) such that the ratio spans a range from less than 0.6 to at least 0.9.
FILED	Wednesday, September 20, 2017
APPL NO	15/709541
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 16/03 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 43/00 (20130101) F02B 77/14 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 6/00 (20130101) Jet-propulsion Plants F02K 5/00 (20130101) Dynamo-electric Machines H02K 7/1807 (20130101) H02K 9/04 (20130101) H02K 9/16 (20130101)
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10738890 — Oil slinger with convective cooling of radial surface

US 10738890	Clark et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Thomas E. Clark (Sanford, Maine); Eric Charles Mundell (South Berwick, Maine); Gary L. Grogg (South Berwick, Maine)
ABSTRACT	Oil slinger systems include a seal runner comprising an annular radial member having a radius (R) and an outer axially extending member having an axial length (L) such that a ratio (L/R) is between 0.8 and 1.4, the annular radial member disposed at a first angle with respect to the outer axially extending member, a heat shield in mechanical communication with the seal runner, and a volume bounded by an outer face of the annular radial member and an inner face of the heat shield. Methods of radial convective cooling include pumping a cooling liquid through the oil slinger system and convectively cooling the oil slinger.
FILED	Thursday, September 05, 2019
APPL NO	16/561471
ART UNIT	3675 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/12 (20130101) F01D 25/18 (20130101) F01D 25/183 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/06 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2230/60 (20130101) F05D 2240/55 (20130101) F05D 2260/20 (20130101) Pistons; Cylinders; Sealings F16J 15/168 (20130101) Original (OR) Class Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101)
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10738996 — Apparatus and method for operating a gas-fired burner on liquid fuels

US 10738996	Roychoudhury et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Precision Combustion, Inc. (North Haven, Connecticut)
ASSIGNEE(S)	PRECISION COMBUSTION, INC. (North Haven, Connecticut)
INVENTOR(S)	Subir Roychoudhury (Madison, Connecticut); Richard Mastanduno (Milford, Connecticut); Bruce Crowder (Hamden, Connecticut); David Lang Spence (Beacon Falls, Connecticut); Francesco Macri (Farmington, Connecticut); Julian David Prada Bernal (Middletown, Connecticut)
ABSTRACT	A gas-fired burner adapted for use on a liquid fuel. A method for essentially smokeless start-up and steady state operation of a gas-fired burner on a liquid fuel. The apparatus integrates a catalytic liquid fuel reformer with a flame burner designed for operation on a gaseous fuel of high Wobbe Index, e.g., natural gas. The method involves reacting a mixture of a liquid fuel and oxidant in a catalytic reformer to obtain a gaseous reformate having a low Wobbe Index; and thereafter combusting the gaseous reformate, optionally augmented with liquid co-fuel and oxidant, in the gas-fired burner under diffusion flame conditions. The invention allows commercial gas-fired appliances to be operated on a liquid fuel, thereby offering advantages in logistics and camp operations.
FILED	Thursday, May 24, 2018
APPL NO	15/988000
ART UNIT	3762 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 3/386 (20130101) C01B 2203/0244 (20130101) C01B 2203/0261 (20130101) C01B 2203/1247 (20130101) C01B 2203/1276 (20130101) Feeding Fuel to Combustion Apparatus F23K 5/002 (20130101) Original (OR) Class F23K 5/10 (20130101) Regulating or Controlling Combustion F23N 1/02 (20130101) F23N 3/08 (20130101)
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10739111 — Cloaking systems and methods

US 10739111	Choi et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	UNIVERSITY OF ROCHESTER (Rochester, New York)
ASSIGNEE(S)	UNIVERSITY OF ROCHESTER (Rochester, New York)
INVENTOR(S)	Joseph S. Choi (Cypress, California); John C. Howell (Jerusalem, Israel)
ABSTRACT	Digital cloaking is a method for practical cloaking, where space, angle, spectrum and phase are discretized. At the sacrifice of spatial resolution, a good approximation to an ideal cloak can be achieved—a cloak that is omnidirectional, broadband, and operational for the visible spectrum, three-dimensional (3D), and phase-matching for the light field, among other attributes. One example of a digital cloak is an active cloak that uses lenticular lenses, similar to integral imaging for 3D displays. With the continuing improvement in commercial digital technology, the resolution limitations of a digital cloak may be minimized, and a wearable cloak can be implemented.
FILED	Thursday, April 21, 2016
APPL NO	15/567805
ART UNIT	2481 — Recording and Compression
CURRENT CPC	Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 3/00 (20130101) Original (OR) Class Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 3/14 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/42 (20130101) Optical Elements, Systems, or Apparatus G02B 27/00 (20130101) G02B 27/0075 (20130101) G02B 27/0081 (20130101) G02B 30/27 (20200101) G02B 2207/123 (20130101) Pictorial Communication, e.g Television H04N 5/74 (20130101) H04N 9/3179 (20130101) H04N 13/229 (20180501) H04N 13/232 (20180501) H04N 13/305 (20180501) H04N 13/307 (20180501)
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10739112 — Impulse dampening system for emergency egress

US 10739112	Renn et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Indian Head, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Philip Alan Renn (La Plata, Maryland); Edward Aloysius Cudahy, IV (Monroe, Georgia); Michael Kaige Qin (Ledyard, Connecticut)
ABSTRACT	An impulse dampening system reduces peak pressure and impulse acoustic pressures of an acoustic wave to a level that permits initiation of an emergency egress system by personnel in a submerged/flooded cockpit following landing or crashing into water. Initiation of the emergency egress system is available in the air or after the aircraft is in the water. The system attenuates the impulse of the acoustic wave at least 35 dB, where the acoustic wave is usually produced when a detonation chord is initiated. The system includes a first layer of dampening media, a second layer of dampening media, a viscous lensing medium between the layers, and a hard shell.
FILED	Thursday, August 15, 2013
APPL NO	13/987620
ART UNIT	3647 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 1/14 (20130101) B64C 1/32 (20130101) B64C 1/1476 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/04 (20130101) F41H 5/0442 (20130101) Original (OR) Class
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10739229 — Systems and methods for measuring absorption coefficients of doped optical fibers

US 10739229	Peysokhan et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Mostafa Peysokhan (Albuquerque, New Mexico); Arash Mafi (Albuquerque, New Mexico)
ABSTRACT	A system for measuring an absorption coefficient of a doped optical fiber may include: a laser source configured to transmit laser light at a selectable wavelength; a single-mode optical fiber including an end configured to splice to the doped optical fiber; two or more multimode fibers at a side of the doped optical fiber, spaced apart along the side of the doped optical fiber, configured to collect spontaneous emissions from the side of the doped optical fiber; and/or a photodiode or power meter connected to the two or more multimode fibers. A method for measuring an absorption coefficient of a doped optical fiber may include: collecting, from a side of the doped optical fiber, an emission spectrum using two or more multimode fibers; and/or calculating the absorption coefficient form using the emission spectrum and McCumber theory.
FILED	Thursday, July 25, 2019
APPL NO	16/522449
ART UNIT	2886 — Optics
CURRENT CPC	Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/33 (20130101) G01M 11/35 (20130101) Original (OR) Class
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10739239 — Rotating magnetic disc medical analyzer and coagulation profiler

US 10739239	Joseph et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	iFirst Medical Technologies, Inc. (Honolulu, Hawaii)
ASSIGNEE(S)	iFirst Medical Technologies, Inc. (Honolulu, Hawaii)
INVENTOR(S)	Luke B. Joseph (Honolulu, Hawaii); Thomas A. Hasling (Honolulu, Hawaii)
ABSTRACT	A medical analyzer and coagulation profiler performs various interrogations on specimens. A motor with reduction gearing moves and a video camera observes the samples, the cartridges or parts thereof. Changes in images are compared and recorded with a central processor that controls a display. Power supply, temperature controller, motor and gearing are mounted in a box which attaches to a smartphone. The smartphone provides the video camera, illumination and central processor that control the movement, temperature and display. The device makes testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and controls a number of parallel or serial devices operating simultaneously or sequentially. A cartridge insertion actuates a circular motion to generate a blood profile based on changes. Change is analyzed with a video camera and processor such as in a smartphone and is plotted to show an amplitude and time. A smartphone provides a specific movement pattern.
FILED	Thursday, June 29, 2017
APPL NO	15/638156
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/14 (20130101) Original (OR) Class G01N 2011/147 (20130101)
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10739247 — Laser characteristic processor

US 10739247	Lee et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronics Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Bryan D. Lee (Merrimack, New Hampshire); Christopher M. Palie (Mont Vernon, New Hampshire); Andrew J. Radl (Dunbarton, New Hampshire)
ABSTRACT	A system and process for testing and analyzing a laser beam is provided. The system and process allows for repeatable testing of a laser beam to provide a beam intensity profile while accounting for variation in measurements attributable to outside factors. The system and process further allows for simultaneous measurement and analysis of a laser beam having multiple wavelengths.
FILED	Wednesday, October 31, 2018
APPL NO	16/176834
ART UNIT	2877 — Optics
CURRENT CPC	Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/32 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1436 (20130101) Original (OR) Class G01N 15/1459 (20130101) G01N 2015/1447 (20130101)
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10739261 — Surface-plasmon opto-magnetic field enhancement for all-optical magnetization switching

US 10739261	Dutta et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Aveek Dutta (West Lafayette, Indiana); Vladimir M. Shalaev (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana); Esteban E. Marinero-Caceres (West Lafayette, Indiana)
ABSTRACT	A magneto-plasmonic nanostructure is disclosed. The structure includes a substrate, and a magneto-plasmonic stack, comprising a nano-sized plasmonic resonator, a nanomagnet, and a capping layer, wherein the nano-sized plasmonic resonator is configured to receive circularly polarized light at an intensity to thereby increase normal component of plasmon-generated opto-magnetic field, H_OM,z, at least at the interface of one of i) the nano-sized plasmonic resonator and the nanomagnet, or ii) the nanomagnet and the capping layer, whereby the H_OM,zdirection is perpendicular to the rotational direction of the circularly polarized light and the nanomagnets in the magneto-plasmonic stack switches its magnetic moment in response to a change of the H_OM,zdirection in response to a change of the rotational direction of the circularly polarized light.
FILED	Tuesday, April 30, 2019
APPL NO	16/399917
ART UNIT	2886 — Optics
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) B82Y 35/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/01 (20130101) G01N 21/553 (20130101) Original (OR) Class G01N 2021/0162 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/1215 (20130101)
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10739353 — Suppression of cytokine release and cytokine storm

US 10739353	Sordillo et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) Medical Research Institute of Infectious Diseases (USAMRIID)
APPLICANT(S)	SignPath Pharma Inc. (Quakertown, Pennsylvania); Avanti Polar Lipids, Inc. (Alabaster, Alabama)
ASSIGNEE(S)	Signpath Pharma, Inc. (Sandy, Utah); Avanti Polar Lipids, Inc. (Alabaster, Alabama)
INVENTOR(S)	Peter P. Sordillo (New York, New York); Lawrence Helson (Quakertown, Pennsylvania); Stephen W. Burgess (Chelsea, Alabama); Walter A. Shaw (Birmingham, Alabama)
ABSTRACT	The present invention includes methods and compositions for ameliorating symptoms or treating one or more adverse reactions triggered by infectious diseases or disease conditions that trigger a widespread release of cytokines in a subject comprising the steps of: identifying the subject in need of amelioration of symptoms or treatment of the infectious diseases or disease conditions that trigger a widespread release of cytokines; and administering one or more pharmaceutical compositions comprising a therapeutically effective amount of a curcumin extract, curcuminoids or synthetic curcumin (S-curcumin) and derivatives thereof, or empty liposomes, dissolved or dispersed in a suitable aqueous or non-aqueous medium sufficient to reduce the level of cytokines in the host.
FILED	Wednesday, December 30, 2015
APPL NO	14/983844
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 31/12 (20130101) A61K 31/12 (20130101) A61K 31/683 (20130101) A61K 31/683 (20130101) A61K 47/12 (20130101) A61K 47/14 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) Original (OR) Class G01N 2333/55 (20130101) G01N 2333/57 (20130101) G01N 2333/523 (20130101) G01N 2333/525 (20130101) G01N 2333/545 (20130101) G01N 2333/5412 (20130101) G01N 2333/5421 (20130101) G01N 2333/5428 (20130101) G01N 2800/24 (20130101) G01N 2800/52 (20130101) Technologies for Adaptation to Climate Change Y02A 50/385 (20180101) Y02A 50/387 (20180101) Y02A 50/397 (20180101)
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10739390 — Resonantly-enhanced optical phase detection of RF signals in LiNBO3

US 10739390	Claussen et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	SPAWAR Systems Center Pacific (San Diego, California)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Stephanie Claussen (Denver, Colorado); Benjamin J. Taylor (Escondido, California); Anna M. Leese de Escobar (Encinitas, California)
ABSTRACT	A system is provided for use with an optical input signal for detecting a phase difference between a first RF signal having a first phase and a second RF signal having a second phase. The system includes and optical waveguide, a first optical resonant cavity, a first RF receiver, a second optical resonant cavity and a second RF receiver. The optical resonant cavities include a non-linear electro-optical material. The first RF receiver affects the first non-linear electro-optical material of the first optical resonant cavity. The second RF receiver affects the second non-linear electro-optical material of first optical resonant cavity. The optical waveguide outputs an optical output signal based on the optical input signal as modified by the first optical resonant cavity as affected by the first RF receiver receiving the first RF signal and as modified by the second optical resonant cavity as affected by the second RF receiver.
FILED	Tuesday, July 17, 2018
APPL NO	16/037567
ART UNIT	2863 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 27/28 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 3/46 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/3551 (20130101) G02F 2001/212 (20130101) G02F 2202/20 (20130101) G02F 2203/15 (20130101)
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10739447 — Systems, methods, and media for encoding and decoding signals used in time of flight imaging

US 10739447	Gutierrez Barragan et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin); The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin); The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Felipe Gutierrez Barragan (Madison, Wisconsin); Mohit Gupta (Madison, Wisconsin); Andreas Velten (Madison, Wisconsin); Eric Breitbach (Madison, Wisconsin); Shree K. Nayar (New York, New York)
ABSTRACT	In accordance with some embodiments, systems, methods and media for encoding and decoding signals used in time-of-flight imaging are provided. In some embodiments, a method for estimating the depth of a scene is provided, comprising: causing a light source to emit modulated light toward the scene based on a modulation function; causing the image sensor to generate a first value based on the modulated light and a first demodulation function of K modulation functions; causing the image sensor to generate a second value; causing the image sensor to generate a third value; and determining a depth estimate for the portion of the scene based on the first value, the second value, the third value, and three correlation functions each including at least one half of a trapezoid wave.
FILED	Friday, September 08, 2017
APPL NO	15/699623
ART UNIT	2482 — Recording and Compression
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/484 (20130101) G01S 7/4865 (20130101) G01S 7/4911 (20130101) Original (OR) Class G01S 7/4915 (20130101) G01S 17/10 (20130101) G01S 17/32 (20130101) G01S 17/36 (20130101) G01S 17/89 (20130101) Image Data Processing or Generation, in General G06T 7/521 (20170101) G06T 2207/10028 (20130101) G06T 2207/10152 (20130101) Pictorial Communication, e.g Television H04N 5/232 (20130101) H04N 5/2256 (20130101)
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10739467 — Methods and systems for testing satellite signal receiver antenna

US 10739467	Wang et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Intelligent Fusion Technology, Inc (Germantown, Maryland)
ASSIGNEE(S)	INTELLIGENT FUSION TECHNOLOGY, INC. (Germantown, Maryland)
INVENTOR(S)	Zhonghai Wang (Germantown, Maryland); Bin Jia (Germantown, Maryland); Xingping Lin (Germantown, Maryland); Tao Wang (Germantown, Maryland); Xingyu Xiang (Germantown, Maryland); Genshe Chen (Germantown, Maryland); Dan Shen (Germantown, Maryland); Khanh Pham (Kirtland AFB, New Mexico); Erik Blasch (Rome, New York)
ABSTRACT	A method for testing satellite signal receiver antenna is provided. The method includes: determining a satellite constellation state indicating status of a plurality of satellites in a satellite constellation; calculating, based on the determined satellite constellation state, initial positions of a plurality of satellite antennas that are used for emulating the satellite constellation; moving the plurality of satellite antennas to the initial positions of the plurality of satellite antennas; calibrating a phase delay of each of the plurality of satellite antennas; broadcasting, by the plurality of satellite antennas, satellite signals to test a satellite signal receiver antenna; determining a movement plan for the plurality of satellite antennas based on the satellite constellation state; and moving the plurality of satellite antennas based on the movement plan to emulate a propagation of the satellite constellation.
FILED	Thursday, January 18, 2018
APPL NO	15/874526
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/23 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 1/288 (20130101) H01Q 3/02 (20130101) H01Q 3/267 (20130101)
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10739650 — Utilizing 2D h-BN nanosheets as the planar-alignment agent in an electro-optical liquid crystal device to improve its optical transmission

US 10739650	Basu
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Rajratan Basu (Annapolis, Maryland)
ABSTRACT	An electro-optical liquid crystal cell comprising a first substrate, a first layer of indium tin oxide (ITO) on the first substrate, a first layer of h-BN on the first layer of ITO on the first substrate, and a layer of liquid crystal on the first layer of h-BN on the first layer of ITO on the first substrate. Furthermore, the electro-optical liquid crystal cell can comprise a second layer of h-BN, a second layer of ITO, and a second substrate. This h-BN cell exhibits the required electro-optic effect needed for a liquid crystal display. This h-BN cell exhibits high optical transmission.
FILED	Thursday, October 17, 2019
APPL NO	16/655346
ART UNIT	2871 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/1347 (20130101) Original (OR) Class G02F 1/13336 (20130101) G02F 1/133784 (20130101) G02F 2001/133302 (20130101) G02F 2001/133354 (20130101) G02F 2001/133357 (20130101) G02F 2001/133565 (20130101)
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10739728 — Molecular clock

US 10739728	Han et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Ruonan Han (Winchester, Massachusetts); Cheng Wang (Cambridge, Massachusetts)
ABSTRACT	A molecular clock which utilizes a rotational spectrum of gaseous molecules in a sub-THz region for clock stabilization is described. The molecular clock has a fast start-up characteristic and is also robust against mechanical vibration or variation of electromagnetic field. Also described is a chip-scale implementation of a molecular clock. In an embodiment, a molecular clock chipset only consumes a DC power of 66 mW. While providing a highly stable, compact and energy efficient time generator of portable devices.
FILED	Thursday, December 27, 2018
APPL NO	16/233982
ART UNIT	2849 — Optics
CURRENT CPC	Time-interval Measuring G04F 5/14 (20130101) G04F 5/145 (20130101) Original (OR) Class Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 17/00 (20130101) Tuning Resonant Circuits; Selecting Resonant Circuits H03J 7/00 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) H03L 7/0992 (20130101) H03L 7/1976 (20130101) Transmission H04B 1/18 (20130101) H04B 1/30 (20130101) H04B 1/1027 (20130101)
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10739748 — Instrumentation composite integration system

US 10739748	Dew et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	LOCKHEED MARTIN CORPORATION (Bethesda, Maryland)
ASSIGNEE(S)	LOCKHEED MARTIN CORPORATION (Bethesda, Maryland)
INVENTOR(S)	Nathaniel Dew (Milford, Connecticut); Jonathan K. Garhart (Seymour, Connecticut)
ABSTRACT	According to an aspect, an apparatus is provided. The apparatus includes a cutter, a spooling mechanism and a computing system. The computing system is configured to drive the cutter to form a channel in the ply based on the stored instrumentation layout. The computing system is additionally configured to drive the spooling mechanism to insert the instrumentation into the formed channel based on the stored instrumentation layout.
FILED	Tuesday, September 25, 2018
APPL NO	16/141114
ART UNIT	2116 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/182 (20130101) Original (OR) Class G05B 2219/36198 (20130101) G05B 2219/49077 (20130101)
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10740116 — Three-dimensional chip-based regular expression scanner

US 10740116	Van Lunteren et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Jan Van Lunteren (Gattikon, Switzerland); James Coghlan (Wappingers Falls, New York); Douglas J. Joseph (Leander, Texas)
ABSTRACT	A method for performing enhanced pattern scanning includes the steps of: providing a three-dimensional memory structure including multiple physical memory elements; compiling multiple programmable finite state machines, each of the programmable finite state machines representing at least one deterministic finite automation data structure, the data structure being distributed over at least a subset of the physical memory elements; configuring a subset of the programmable finite state machines to operate in parallel on a same input data stream, while each of the subset of programmable finite state machines processes a different pattern subset; and providing a local result processor, the local result processor transferring at least a part of a match state from the deterministic finite automation data structures to corresponding registers within the local result processor, the part of the match state being manipulated being based on instructions embedded within the deterministic finite automation data structures.
FILED	Tuesday, September 01, 2015
APPL NO	14/841825
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 9/4498 (20180201) Original (OR) Class G06F 30/34 (20200101) G06F 30/39 (20200101)
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10740282 — Interconnect circuits at three-dimensional (3-D) bonding interfaces of a processor array

US 10740282	Rivera et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Rodrigo Alvarez-Icaza Rivera (San Jose, California); John V. Arthur (Mountain View, California); John E. Barth, Jr. (Willston, Vermont); Andrew S. Cassidy (San Jose, California); Subramanian S. Iyer (Mount Kisco, New York); Bryan L. Jackson (Fremont, California); Paul A. Merolla (Palo Alto, California); Dharmendra S. Modha (San Jose, California); Jun Sawada (Austin, Texas)
ABSTRACT	Embodiments of the invention relate to processor arrays, and in particular, a processor array with interconnect circuits for bonding semiconductor dies. One embodiment comprises multiple semiconductor dies and at least one interconnect circuit for exchanging signals between the dies. Each die comprises at least one processor core circuit. Each interconnect circuit corresponds to a die of the processor array. Each interconnect circuit comprises one or more attachment pads for interconnecting a corresponding die with another die, and at least one multiplexor structure configured for exchanging bus signals in a reversed order.
FILED	Monday, February 26, 2018
APPL NO	15/904784
ART UNIT	2822 — Semiconductors/Memory
CURRENT CPC	Electric Digital Data Processing G06F 15/803 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/8221 (20130101) H01L 23/50 (20130101) H01L 25/04 (20130101) H01L 25/0652 (20130101) H01L 27/0207 (20130101) H01L 27/0688 (20130101) H01L 27/11526 (20130101) H01L 27/11551 (20130101) H01L 27/11573 (20130101) H01L 27/11578 (20130101) H01L 2224/16145 (20130101) H01L 2224/16145 (20130101) H01L 2224/32145 (20130101) H01L 2224/32145 (20130101) H01L 2224/32145 (20130101) H01L 2224/48227 (20130101) H01L 2224/48227 (20130101) H01L 2224/73204 (20130101) H01L 2224/73204 (20130101) H01L 2224/73265 (20130101) H01L 2224/73265 (20130101) H01L 2225/06513 (20130101) H01L 2225/06555 (20130101) H01L 2225/06593 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101)
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10740348 — Application programming interface and hypergraph transfer protocol supporting a global hypergraph approach to reducing complexity for accelerated multi-disciplinary scientific discovery

US 10740348	Smart
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	Georgetown University (Washington, District of Columbia)
ASSIGNEE(S)	Georgetown University (Washington, District of Columbia)
INVENTOR(S)	J. Cory Smart (Clarksville, Maryland)
ABSTRACT	A system and method for connecting one or more client applications with one or more knowledge representation servers and communicating there between includes an application programming interface (API) and a hypergraph transfer protocol (HGTP), for facilitating communication between the one or more client applications and one or more knowledge representation servers responsive to a client application request. The client application request includes an API call for a specific entity that is received by a first knowledge representation server. If the first knowledge representation server does not manage the specific entity, the first knowledge representation server forwards the specific entity call to a second knowledge representation server via the HGTP using a universal unique identifier (UUID) associated with the specific entity having encoded therein a network address for the second knowledge representation server.
FILED	Monday, June 05, 2017
APPL NO	15/614131
ART UNIT	2162 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/26 (20190101) Original (OR) Class G06F 16/367 (20190101) G06F 16/2264 (20190101) Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) G06N 5/022 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 12/00 (20130101) H04L 12/4625 (20130101)
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10740493 — Phosphor-loaded waveguide

US 10740493	Geis et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute Of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Michael W. Geis (Acton, Massachusetts); Joshua Kramer (Branchburg, New Jersey); Karen M.G.V. Gettings (Carlisle, Massachusetts); Marc J. Burke (Pelham, New Hampshire); Mankuan M. Vai (Sudbury, Massachusetts); Theodore M. Lyszczarz (Concord, Massachusetts)
ABSTRACT	An improved waveguide is disclosed. The waveguide utilizes a luminescent material disposed within or around its perimeter to introduce additional light into the waveguide. For example, the waveguide may include a plurality of planar layers having different refractive indexes. A luminescent material may be disposed along the outer edge of these layers. When light from within the waveguide strikes the luminescent material, it emits light, thereby adding to the light in the waveguide. Not only does the luminescent material introduce more light into the waveguide, it also introduces more light sources, thereby making it more difficult to introduce a probe without blocking at least a portion of the light destined for the image sensor. The luminescent material may be a phosphor.
FILED	Monday, February 29, 2016
APPL NO	15/548027
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/0003 (20130101) G02B 6/43 (20130101) G02B 6/4214 (20130101) G02B 6/4215 (20130101) G02B 6/4295 (20130101) G02B 6/4298 (20130101) Electric Digital Data Processing G06F 21/70 (20130101) Original (OR) Class G06F 21/72 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00577 (20130101) G06K 2009/0059 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/04 (20130101) H04L 63/162 (20130101)
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10740646 — Programmable cellular automata for memory search, recall, simulation, and improvisation

US 10740646	Yeoh et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Terence S. Yeoh (Pasadena, California); Nehal Desai (El Segundo, California)
ABSTRACT	An architecture and process are provided that encodes information into a cellular automata memory structure such that it can be recalled utilizing unique memory anchors (engrams) in a manner that both identifies and relates each piece of information relative to other data points. The automata may be individually programmable with a limited, local ruleset that activates other cellular automata based on prior patterns that were fed into the array. Deep Learning Neural Network (DLNN) systems may be probed to understand what discriminators are being used to classify the data, which is not possible with conventional DLNN techniques.
FILED	Monday, October 30, 2017
APPL NO	15/798020
ART UNIT	2669 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/527 (20130101) G06K 9/4628 (20130101) Original (OR) Class G06K 9/6219 (20130101) G06K 9/6247 (20130101) G06K 9/6274 (20130101) G06K 2009/6213 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/084 (20130101)
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10740672 — Capacitative artificial neural networks

US 10740672	Yang et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	Univerity of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Jianhua Yang (Hadley, Massachusetts); Qiangfei Xia (Amherst, Massachusetts); Zhongrui Wang (Amherst, Massachusetts); Qing Wu (Manilus, New York); Mark R. McLean (Severna Park, Maryland)
ABSTRACT	In one aspect, an apparatus includes a diffusive memristor, and a capacitor integrated in series with the diffusive memristor, wherein the apparatus exhibits volatile memcapacitive behavior. In another aspect, a device includes a transistor, and a memcapacitor integrated onto the gate of the transistor, wherein the memcapacitor exhibits volatile memcapacitive behavior. The memcapacitor includes a diffusive memristor, and a capacitor integrated in series with the diffusive memristor, wherein the gate dielectric of the transistor is replaced with the memcapacitor. In another aspect, an artificial neuron device includes a transistor, a volatile memcapacitor that is configured to operate as an electrically floating gate of the transistor, and one or more synaptic circuits that are coupled to the volatile memcapacitor. The volatile memcapacitor includes a diffusive memristor, and a capacitor integrated in series with the diffusive memristor.
FILED	Monday, April 01, 2019
APPL NO	16/371736
ART UNIT	2893 — Semiconductors/Memory
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/092 (20130101) H01L 28/65 (20130101) H01L 29/513 (20130101) H01L 29/517 (20130101) H01L 29/518 (20130101) H01L 29/788 (20130101) H01L 29/4958 (20130101) H01L 29/42324 (20130101) H01L 45/145 (20130101) H01L 45/146 (20130101) H01L 45/1233 (20130101) H01L 45/1253 (20130101)
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10740884 — System and method for high precision multi-aperture spectral imaging

US 10740884	McCall et al.
FUNDED BY	Department of Defense (DOD) Defense Health Agency (DHA) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA)
APPLICANT(S)	SPECTRAL MD, INC. (Dallas, Texas)
ASSIGNEE(S)	SPECTRAL MD, INC. (Dallas, Texas)
INVENTOR(S)	Brian McCall (Dallas, Texas); Wensheng Fan (Plano, Texas); Jason Dwight (Dallas, Texas); Zhicun Gao (Plano, Texas); Jeffrey E. Thatcher (Irving, Texas); John Michael DiMaio (Dallas, Texas)
ABSTRACT	Generally described, one or more aspects of the present application correspond to systems and techniques for spectral imaging using a multi-aperture system with curved multi-bandpass filters positioned over each aperture. The present disclosure further relates to techniques for implementing spectral unmixing and image registration to generate a spectral datacube using image information received from such imaging systems. Aspects of the present disclosure relate to using such a datacube to analyze the imaged object, for example to analyze tissue in a clinical setting, perform biometric recognition, or perform materials analysis.
FILED	Thursday, January 09, 2020
APPL NO	16/738910
ART UNIT	2481 — Recording and Compression
CURRENT CPC	Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 7/33 (20170101) G06T 7/55 (20170101) G06T 7/62 (20170101) G06T 2207/10036 (20130101) G06T 2207/10144 (20130101) G06T 2207/20221 (20130101) Pictorial Communication, e.g Television H04N 5/265 (20130101) H04N 5/2254 (20130101) H04N 5/2256 (20130101) H04N 5/2356 (20130101)
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10740965 — Mapping complex building models

US 10740965	Young et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) U.S. Army Contracting Command (ACC) Redstone Arsenal (REDSTONE) Small Business Administration (SBA) Small Business Innovation Research (SBIR) Department of Transportation (USDOT) Federal Highway Administration (FHWA) National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S)	TRX Systems, Inc. (Greenbelt, Maryland)
ASSIGNEE(S)	TRX SYSTEMS, INC. (Greenbelt, Maryland)
INVENTOR(S)	Travis Young (Rockville, Maryland); Daniel Hakim (Silver Spring, Maryland); Daniel Franchy (Catonsville, Maryland); Jared Napora (Severn, Maryland); John Karvounis (Bowie, Maryland); Jonathan Fetter Degges (Washington, District of Columbia); Tim Wang (Germantown, Maryland); Benjamin Funk (Hanover, Maryland); Carole Teolis (Glendale, Maryland); Carol Politi (Bethesda, Maryland); Stuart Woodbury (Ellicott City, Maryland)
ABSTRACT	Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device.
FILED	Friday, May 31, 2019
APPL NO	16/428519
ART UNIT	2675 — Facsimile; Printer; Color; halftone; Scanner; Computer Graphic Processing; 3-D Animation; Display Color; Attributes; Object Processing; Hardware and Memory
CURRENT CPC	Electric Digital Data Processing G06F 30/13 (20200101) Image Data Processing or Generation, in General G06T 17/05 (20130101) Original (OR) Class
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10741129 — Reconfigurable display and method therefor

US 10741129	Wacyk et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Sensors Directorate (AFRL/PKSE) Department of the Army (DOA) Aberdeen Proving Ground (APG) Combat Capabilities Development Command (CCDC) Night Vision and Electronic Sensors Directorate (NVESD)
APPLICANT(S)	eMagin Corporation (Hopewell Junction, New York); UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY (, None)
ASSIGNEE(S)	eMagin Corporation (Hopewell Junction, New York); UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia)
INVENTOR(S)	Ihor Wacyk (Hopewell Junction, New York); Hyuk Sang Kwon (Sunnyvale, California); Russell Draper (Hopewell Junction, New York); David Fellowes (Hopewell Junction, New York)
ABSTRACT	An image rendering system comprising a pixel array and variable-density column and row scanner circuits is disclosed. The variable-density column and row scanner circuits enable software-based reconfiguration of the active display area within the available screen area of the display. In addition, a hardware restore-to-black function is provided that enables pixels outside of the desired image region to be driven to black without their requiring image data or excitation. As a result, the functionality of the functionality of the display can be reconfigured to match the desired image region on a frame-by-frame basis. Therefore, displays in accordance with the present invention can operate at higher frame rates and with less power consumption that prior-art displays.
FILED	Tuesday, August 01, 2017
APPL NO	15/666041
ART UNIT	2622 — Selective Visual Display Systems
CURRENT CPC	Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/3233 (20130101) G09G 3/3266 (20130101) Original (OR) Class G09G 3/3291 (20130101) G09G 2300/0842 (20130101) G09G 2310/04 (20130101) G09G 2310/0213 (20130101) G09G 2310/0251 (20130101) G09G 2310/0259 (20130101) G09G 2310/0262 (20130101)
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10741313 — Bus bar assembly with integrated surge arrestor

US 10741313	Familiant et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Eaton Intelligent Power Limited (Dublin, Ireland)
ASSIGNEE(S)	Eaton Intelligent Power Limited (, Ireland)
INVENTOR(S)	Yakov L. Familiant (Thiensville, Wisconsin); Paul J. Rollmann (Menomonee Falls, Wisconsin); Andrew A. Rockhill (Waukesha, Wisconsin)
ABSTRACT	An apparatus includes a laminated bus bar assembly with first and second bus bars and an intervening insulator layer. A surge arrestor (e.g., a metal oxide varistor) has a body mounted on the bus bar assembly and first and second terminals on first and second opposite sides of the body. In some embodiments, the body may be at least partially disposed in an opening in the first bus bar and the second terminal may be conductively bonded to a surface of the second bus bar that faces the insulator layer. In some embodiments, the second terminal may include a conductive stud passing through an opening in the second bus bar. The apparatus may include a spring clamp attached to the first bus bar and contacting the first side of the body to retain the body.
FILED	Wednesday, February 06, 2019
APPL NO	16/269162
ART UNIT	2847 — Electrical Circuits and Systems
CURRENT CPC	Resistors H01C 7/12 (20130101) Original (OR) Class Installation of Electric Cables or Lines, or of Combined Optical and Electric Cables or Lines H02G 5/005 (20130101)
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10741317 — Method of fabrication of composite monolithic structures

US 10741317	Chu
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Missile Defense Agency (MDA) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) National Security Engineering Center (NSEC) Federally Funded Research and Development Center (FFRDC) Operated by MITRE Corporation (MITRE) at Bedford, MA Under Secretary of Defense for Acquisition and Sustainment (USDA&S) National Geospatial Intelligence Agency (NGA)
APPLICANT(S)	The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S)	The MITRE Corporation (McLean, Virginia)
INVENTOR(S)	Alejandro Chu (Madison, Alabama)
ABSTRACT	Fabricating composite monolithic structures to achieve optimal electrical, thermal, and mechanical properties through the elimination of air is discussed herein. A method of fabricating a composite structure includes coating an insulating layer with an uncured binding material and performing a first curing process on the uncured binding material to form a first stage cured binding material on the insulating layer without introduction of air pockets in a conventional manufacturing atmospheric environment. The method further includes disposing the insulating layer on an array of conductive structures. The first stage cured binding material is positioned between the insulating layer and the array of conductive structures. The method further includes performing a second curing process on the first stage cured binding material to form a cured binding material, and forming cured regions between adjacent conductive structures of the array of conductive structures.
FILED	Friday, August 11, 2017
APPL NO	15/674790
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 5/06 (20130101) Original (OR) Class H01F 19/00 (20130101) H01F 27/288 (20130101) H01F 27/323 (20130101) H01F 41/122 (20130101) H01F 41/125 (20130101)
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10741337 — Mesoporous nanocrystalline film architecture for capacitive storage devices

US 10741337	Dunn et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Bruce S. Dunn (Los Angeles, California); Sarah H. Tolbert (Los Angeles, California); John Wang (Glendora, California); Torsten Brezesinski (Karlsruhe, Germany); George Gruner (Los Angeles, California)
ABSTRACT	A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling stability. Charge storage devices with electrodes using the construct can use three different charge storage mechanisms immersed in an electrolyte: (1) cations can be stored in a thin double layer at the electrode/electrolyte interface (non-faradaic mechanism); (2) cations can interact with the bulk of an electroactive material which then undergoes a redox reaction or phase change, as in conventional batteries (faradaic mechanism); or (3) cations can electrochemically adsorb onto the surface of a material through charge transfer processes (faradaic mechanism).
FILED	Tuesday, March 13, 2018
APPL NO	15/919295
ART UNIT	2848 — Electrical Circuits and Systems
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 99/00 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/26 (20130101) H01G 11/28 (20130101) H01G 11/36 (20130101) H01G 11/46 (20130101) H01G 11/48 (20130101) H01G 11/84 (20130101) Original (OR) Class H01G 11/86 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 999/99 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/948 (20130101)
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10741649 — High mobility doped metal oxide thin films and reactive physical vapor deposition methods of fabricating the same

US 10741649	Sachet et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF)
APPLICANT(S)	North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)	NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
INVENTOR(S)	Edward Sachet (Raleigh, North Carolina); Christopher Shelton (Raleigh, North Carolina); Jon-Paul Maria (Raleigh, North Carolina); Kyle Patrick Kelley (Lake Lure, North Carolina); Evan Lars Runnerstrom (Durham, North Carolina)
ABSTRACT	A method of forming a metal oxide includes providing a reactive deposition atmosphere having an oxygen concentration of greater than about 20 percent in a chamber including a substrate therein. A pulsed DC signal is applied to a sputtering target comprising a metal, to sputter metal particles therefrom. A doping element may be supplied from a doping source (such as an alloyed metal target) in the reaction chamber. An electrically conductive metal oxide film comprising an oxide of the metal is deposited on the substrate responsive to a reaction between the metal particles and the reactive deposition atmosphere. Related devices are also discussed.
FILED	Thursday, May 24, 2018
APPL NO	15/988883
ART UNIT	2811 — Semiconductors/Memory
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/35 (20130101) C23C 14/0042 (20130101) C23C 14/0057 (20130101) C23C 14/086 (20130101) C23C 14/345 (20130101) C23C 14/352 (20130101) C23C 14/548 (20130101) C23C 14/3485 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/477 (20130101) H01L 21/02266 (20130101) H01L 29/45 (20130101) H01L 29/267 (20130101) Original (OR) Class H01L 29/458 (20130101) H01L 29/7869 (20130101) H01L 31/022466 (20130101)
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10741744 — Switchable superconducting Josephson junction device for low energy information storage and processing

US 10741744	Moodera et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusets Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Jagadeesh S. Moodera (Somerville, Massachusetts); Juan Pedro Cascales Sandoval (Somerville, Massachusetts); Yota Takamura (Cambridge, Massachusetts)
ABSTRACT	A switchable Josephson junction is provided that includes a plurality of ferromagnetic insulators that are defined by their respective magnetic alignments. A first superconducting layer that is positioned between any two of the ferromagnetic insulators, wherein the conductive state is controlled by the relative magnetization orientation of the ferromagnetic insulators where the first superconducting layer is superconducting when the two magnetizations are aligned in antiparallel but it turns normally conducting when the magnetic alignment is parallel. A second superconducting layer is adjacent one of the ferromagnetic layers, wherein Josephson tunneling occurs between the first superconducting layer and second superconducting layer across one of the ferromagnetic layers.
FILED	Monday, September 24, 2018
APPL NO	16/139938
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/10 (20130101) H01L 39/16 (20130101) H01L 39/025 (20130101) H01L 39/121 (20130101) H01L 39/223 (20130101) Original (OR) Class
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10741759 — Diffusive memristor and device for synaptic emulator

US 10741759	Yang et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Air Force Research Laboratory (AFRL) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Jianhua Yang (Hadley, Massachusetts); Qiangfei Xia (Amherst, Massachusetts); Mark McLean (Severna Park, Maryland); Qing Wu (Manilus, New York); Mark Barnell (Clay, New York)
ABSTRACT	A diffusive memristor device and an electronic device for emulating a biological synapse are disclosed. The diffusive memristor device includes a bottom electrode, a top electrode formed opposite the bottom electrode, and a dielectric layer disposed between the top electrode and the bottom electrode. The dielectric layer comprises silver doped silicon oxynitride (SiO_xN_y:Ag). In an alternate implementation, the dielectric layer comprises silver doped silicon oxide (Ag:SiO₂). An electronic synapse emulation device is also disclosed. The synapse emulation device includes a diffusive memristor device, a drift memristor device connected in series with the diffusive memristor device, a first voltage pulse generator connected to the diffusive memristor device, and a second voltage pulse generator connected to the drift memristor device. Application of a signal from one of the first voltage pulse generator or the second voltage pulse generator allows the synapse emulation device to exhibit long-term plasticity.
FILED	Wednesday, September 26, 2018
APPL NO	16/142310
ART UNIT	2896 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/085 (20130101) H01L 45/145 (20130101) H01L 45/146 (20130101) H01L 45/1233 (20130101) H01L 45/1253 (20130101) H01L 45/1266 (20130101) Original (OR) Class
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10741793 — Light emitting device including blue emitting quantum dots and method

US 10741793	Niu et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Advanced Technology Program (NIST-ATP) Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	SAMSUNG RESEARCH AMERICA, INC. (Mountain View, California)
ASSIGNEE(S)	SAMSUNG RESEARCH AMERICA, INC. (Mountain View, California)
INVENTOR(S)	Yuhua Niu (Waltham, Massachusetts); Peter T. Kazlas (Sudbury, Massachusetts)
ABSTRACT	A method for preparing a light emitting device comprising: disposing an electron-injection layer comprising a metal oxide on a cathode, disposing a first layer adjacent the electron-injection layer, the first layer comprising a small molecule material with a bandgap of at least about 3 eV capable of blocking holes, forming an emissive layer comprising quantum dots capable of emitting blue light upon excitation at a surface of the first layer opposite the electron-injection layer; disposing a second layer comprising a material capable of transporting holes and blocking electrons with a bandgap of at least about 3 eV adjacent a surface of the emissive layer opposite the first layer, and disposing an anode over the second layer. A light-emitting device is also disclosed.
FILED	Thursday, July 03, 2014
APPL NO	14/323900
ART UNIT	2817 — Semiconductors/Memory
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/025 (20130101) C09K 11/565 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0026 (20130101) H01L 51/56 (20130101) H01L 51/502 (20130101) H01L 51/5088 (20130101) H01L 51/5092 (20130101) H01L 51/5096 (20130101) H01L 51/5262 (20130101) Original (OR) Class H01L 2251/55 (20130101) H01L 2251/556 (20130101) H01L 2251/558 (20130101) H01L 2251/5353 (20130101) H01L 2251/5369 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 33/10 (20130101) H05B 33/12 (20130101)
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10741901 — Low-profile stacked patch radiator with integrated heating circuit

US 10741901	Chang et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Contracting Command (ACC) Redstone Arsenal (REDSTONE) Aviation and Missile Life Cycle Management Command (AMCOM) Program Executive Office Missiles and Space (PEOMS)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Yueh-Chi Chang (Northborough, Massachusetts); Brandon K.W. Mui (Chelmsford, Massachusetts); Stephen J. Pereira (Hopedale, Massachusetts); Richard S. Young (Ludlow, Massachusetts); Gregory M. Fagerlund (Peabody, Massachusetts); Wayne B. Mattis (Townsend, Massachusetts)
ABSTRACT	An apparatus includes a stacked patch radiator having (i) a lower patch and (ii) an upper patch located above and separated from the lower patch. The upper patch includes first and second conductive patches that are separated from one another. The apparatus also includes a heating circuit integrated in the stacked patch radiator. At least a portion of the heating circuit is positioned between the first and second conductive patches of the upper patch. The stacked patch radiator can be configured to radiate at a specified frequency band and can have a thickness that is less than one tenth of wavelengths within the specified frequency band. The upper patch can include conductive vias electrically connecting the conductive patches. The conductive patches and the conductive vias can form an isolation cage configured to reduce a signal loss associated with a presence of at least the portion of the heating circuit between the conductive patches.
FILED	Tuesday, October 17, 2017
APPL NO	15/786474
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/02 (20130101) Original (OR) Class H01Q 1/38 (20130101) H01Q 1/523 (20130101) H01Q 3/38 (20130101) H01Q 9/0414 (20130101) H01Q 9/0457 (20130101) H01Q 21/065 (20130101) H01Q 21/0075 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10741907 — Lightweight spiral antenna array packaging approach

US 10741907	Krueger et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC)
APPLICANT(S)	BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Michael J. Krueger (Bedford, New Hampshire); Frank D. Phillips (Bedford, New Hampshire); Scott M. Willcutt (Tilton, New Hampshire)
ABSTRACT	The system and method for lightweight spiral antenna array packaging uses a foam core and metallic elements such that the foam core is machined to accept the folded metallic elements to create a compact and light weight assembly. The assembly can be bonded to other assemblies to form arrays. The array is then encapsulated in a prepreg fiberglass skin with a conductive layer of fabric/screen therein.
FILED	Tuesday, November 20, 2018
APPL NO	16/195984
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/36 (20130101) H01Q 1/40 (20130101) Original (OR) Class
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10741914 — Planar ultrawideband modular antenna array having improved bandwidth

US 10741914	Vouvakis et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Research Laboratory (NRL)
APPLICANT(S)	UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts); THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia)
ASSIGNEE(S)	UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts); THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia)
INVENTOR(S)	Marinos N. Vouvakis (Amherst, Massachusetts); Rick W. Kindt (Arlington, Virginia); John T. Logan (Warwick, Rhode Island)
ABSTRACT	Structures and configurations for planar ultrawideband modular antenna arrays. One example of a PUMA array includes an unbalanced RF interface, a lattice of horizontal dipole segments directly fed with the unbalanced RF interface, the lattice being arranged in either a dual-offset dual-polarized configuration or a single-polarization configuration, and a metallic plate capacitively-coupled to the lattice of horizontal dipole segments and pinned to a ground plane with a first plated via.
FILED	Thursday, February 25, 2016
APPL NO	15/553064
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 5/25 (20150115) Original (OR) Class H01Q 5/42 (20150115) H01Q 5/48 (20150115) H01Q 9/065 (20130101) H01Q 9/285 (20130101) H01Q 21/24 (20130101) H01Q 21/062 (20130101)
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10742467 — Digital dynamic delay for analog power savings in multicarrier burst waveforms

US 10742467	Civerolo et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Information Warfare Center (NIWC) Naval Information Warfare Center Pacific (NIWCPACIFIC)
APPLICANT(S)	Government of the United States as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)	United States of America as represented by Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Michael P. Civerolo (San Diego, California); Nicholas A. Lumsden (Escondido, California); Drew E. Overturf (San Diego, California)
ABSTRACT	A signal processor is provided for use with a first signal generator and a second signal generator, wherein the first signal generator provides a first signal having a first amplitude and the second signal generator provides a second signal having a second amplitude. The signal processor includes: a threshold component that stores a threshold value; a threshold detection component that generates a sum of the first amplitude and the second amplitude, compares the sum with the threshold value, generates a modification required signal when the sum is greater than the threshold value; a delay component that generates a delay signal; and a delay processor operable to output an output signal based on the sum of a modified first signal and the second signal when the sum is greater than the threshold value.
FILED	Wednesday, July 10, 2019
APPL NO	16/508047
ART UNIT	2632 — Digital Communications
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 27/2614 (20130101) Original (OR) Class H04L 27/2627 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10742473 — Enhanced signal acquisition based on adaptive multiresolution modulation

US 10742473	James et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Information Warfare Center (NIWC) Naval Information Warfare Center Pacific (NIWCPACIFIC)
APPLICANT(S)	United States of America as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)	United States Government as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Justin O'Neal James (San Diego, California); Michael Patrick Daly (San Diego, California)
ABSTRACT	A transmitter in a network transmits transmissions in accordance with an asymmetric signal constellation. A channel impairment in the network is detected. In response, a transmitter adjustment value for adjusting modulations at the transmitter is determined, the transmitter adjustment value determined to increase asymmetry of the asymmetric signal constellation. Signal acquisition may be improved by transmitting, at the transmitter, transmissions, based on transmitting using the determined transmitter adjustment value.
FILED	Thursday, October 03, 2019
APPL NO	16/592641
ART UNIT	2632 — Digital Communications
CURRENT CPC	Transmission H04B 1/02 (20130101) H04B 1/06 (20130101) H04B 17/15 (20150115) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/36 (20130101) H04L 27/38 (20130101) H04L 27/3488 (20130101) Original (OR) Class H04L 41/0816 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10743092 — Low-crosstalk electro-optical Mach-Zehnder switch

US 10743092	Dupuis et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Nicolas Dupuis (New York, New York); Benjamin G. Lee (Ridgefield, Connecticut); Alexander V. Rylyakov (Staten Island, New York); Mehmet Soyuer (Stamford, Connecticut)
ABSTRACT	Optical switches and methods of switching include a first hybrid coupler configured to accept an input and to provide two branches. A phase tuner on a first branch includes a Mach-Zehnder phase shifter configured to shift a signal on the first branch by a selected phase. A loss compensator on a second branch is configured to match a loss incurred on the first branch. A second hybrid coupler is configured to recombine the two branches such that the phase shift generated by the phase tuner determines which output of the second hybrid coupler is used.
FILED	Monday, June 22, 2015
APPL NO	14/746573
ART UNIT	2636 — Optical Communications
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0147 (20130101) G02F 1/225 (20130101) G02F 1/3136 (20130101) G02F 2001/212 (20130101) Transmission H04B 10/0795 (20130101) Multiplex Communication H04J 14/0212 (20130101) Selecting H04Q 11/0005 (20130101) Original (OR) Class H04Q 2011/0035 (20130101) H04Q 2011/0039 (20130101) H04Q 2011/0041 (20130101) H04Q 2011/0049 (20130101)
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National Science Foundation (NSF)

10736684 — Miniature inductive heating device

US 10736684	Juan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Human Resource Development (HRD)
APPLICANT(S)	Eduardo J. Juan (Cabo Rojo, Puerto Rico); Madeline Torres-Lugo (Cabo Rojo, Puerto Rico); Jorge L. Castro-Torres (Las Piedras, Puerto Rico)
ASSIGNEE(S)	University of Puerto Rico (San Juan, Puerto Rico)
INVENTOR(S)	Eduardo J. Juan (Cabo Rojo, Puerto Rico); Madeline Torres-Lugo (Cabo Rojo, Puerto Rico); Jorge L. Castro-Torres (Las Piedras, Puerto Rico)
ABSTRACT	An induction heating coil is positioned inside a tube-like instrument having dimensions similar to current laparoscopic instruments. Magnetic field intensities of up to 15 kA/m at a frequency of 289 kHz are achieved while the instrument is operated at safe temperatures. A cooling agent system maintains a desired temperature inside the instrument and temperatures sensors monitor the temperature of the cooling agent as well as the temperature of the induction heating coil to safely operate the instrument within operating temperatures.
FILED	Friday, February 23, 2018
APPL NO	15/903171
ART UNIT	3754 — Fluid Handling and Dispensing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/082 (20130101) Original (OR) Class A61B 2018/00023 (20130101) A61B 2018/00178 (20130101) A61B 2018/00815 (20130101) A61B 2018/00821 (20130101) A61B 2018/00875 (20130101) A61B 2018/00982 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/06 (20130101) H05B 6/42 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10736765 — Knee orthosis with variable stiffness and damping

US 10736765	Lahiff et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Christina-Anne Kathleen Lahiff (St. Petersburg, Florida); Kyle Brandon Reed (Tampa, Florida); Seok Hun Kim (Tampa, Florida); Tyagi Ramakrishnan (Tampa, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida)
INVENTOR(S)	Christina-Anne Kathleen Lahiff (St. Petersburg, Florida); Kyle Brandon Reed (Tampa, Florida); Seok Hun Kim (Tampa, Florida); Tyagi Ramakrishnan (Tampa, Florida)
ABSTRACT	A small, lightweight, adjustable knee orthosis for restoring gait symmetry. The orthosis includes a rotary damper for variable damping at the knee joint of the user, and a spring member for variable stiffness at the knee joint of the user. An exemplary application of the device is as a rehabilitation device for individuals who have had a stroke, as the device is designed to induce larger knee flexion as an aftereffect.
FILED	Monday, November 21, 2016
APPL NO	15/357327
ART UNIT	3786 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/0125 (20130101) Original (OR) Class A61F 2005/0169 (20130101) A61F 2005/0179 (20130101)
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10736773 — Devices, systems, and methods for managing patient temperature and correcting cardiac arrhythmia

US 10736773	Kulstad et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Advanced Cooling Therapy, Inc. (Chicago, Illinois)
ASSIGNEE(S)	ADVANCED COOLING THERAPY, INC. (Chicago, Illinois)
INVENTOR(S)	Erik Kulstad (Chicago, Illinois); Patrick Shanley (Chicago, Illinois)
ABSTRACT	Methods, devices, and systems for temperature management and ventricular defibrillation are disclosed. Methods, devices, and systems for positioning an electrode in the esophagus of a subject and managing the core body temperature of the subject are disclosed. The use of esophageal heat transfer devices to deliver an electrode for use in delivering an electrical shock to the myocardium is disclosed.
FILED	Wednesday, March 12, 2014
APPL NO	14/206020
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/12 (20130101) Original (OR) Class A61F 2007/0054 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/39 (20130101) A61N 1/0517 (20130101)
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10736915 — Nylon-3 co-polymers and synthetic lung surfactant compositions containing same

US 10736915	Gellman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Science Foundation (NSF)
APPLICANT(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin); NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin); NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Samuel H. Gellman (Madison, Wisconsin); Shannon S. Stahl (Madison, Wisconsin); Brendan P. Mowery (San Marcos, California); Annelise Barron (Palo Alto, California); Michelle Dohm (Palos Park, Illinois)
ABSTRACT	Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic proteins that are critical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restricted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-B mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, are prepared by ring-opening polymerization of β-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B. Attachment of an N-terminal octadecanoyl unit to the nylon-3 copolymers affords further improvements by reducing the percent surface area compression to reach low minimum surface tension.
FILED	Monday, February 05, 2018
APPL NO	15/888720
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0082 (20130101) A61K 31/785 (20130101) Original (OR) Class A61K 47/32 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/22 (20130101) Compositions of Macromolecular Compounds C08L 77/02 (20130101)
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10737323 — Devices and methods for three-dimensional printing

US 10737323	Torabi et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	3DEO, Inc. (Gardena, California)
ASSIGNEE(S)	3DEO, INC. (Gardena, California)
INVENTOR(S)	Payman Torabi (Los Angeles, California); Matthew Petros (Tarzana, California)
ABSTRACT	The present disclosure provides systems and methods for the formation of three-dimensional objects. A method for forming a three-dimensional object may comprise alternately and sequentially applying a stream comprising a binding substance to an area of a layer of powder material in a powder bed, and generating at least one perimeter of the three-dimensional object in the area. The stream may be applied in accordance with a model design of the three-dimensional object. The at least one perimeter may generated in accordance with the model design.
FILED	Monday, April 30, 2018
APPL NO	15/966746
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/008 (20130101) Original (OR) Class B22F 3/24 (20130101) B22F 2003/247 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/00 (20141201)
VIEW PATENT	@ USPTO: Full Text PDF

10737398 — Continuum devices and control methods thereof

US 10737398	Remirez et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Andria A. Remirez (Nashville, Tennessee); Daniel Caleb Rucker (Knoxville, Tennessee); Robert James Webster, III (Nashville, Tennessee)
ABSTRACT	Continuum robots and similar devices and methods and systems for controlling such devices are provided. The devices can include rods comprising strips, that are pre-curved, or both. Also provided is a system and method for modeling and controlling the configuration and operation of such devices.
FILED	Friday, September 19, 2014
APPL NO	14/491223
ART UNIT	3666 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Diagnosis; Surgery; Identification A61B 34/30 (20160201) A61B 34/71 (20160201) A61B 2034/306 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 9/104 (20130101) B25J 18/06 (20130101) Original (OR) Class
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10737434 — Methods and systems for fast imprinting of nanometer scale features in a workpiece

US 10737434	Dow et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)	North Carolina State University (Raleigh, North Carolina)
INVENTOR(S)	Thomas A. Dow (Cary, North Carolina); Erik Zdanowicz (Pullman, Washington); Alexander Sohn (Fuquay-Varina, North Carolina); Ron Scattergood (Cary, North Carolina); William John Nowak, Jr. (Cary, North Carolina)
ABSTRACT	The subject matter described herein relates to methods and systems for fast imprinting of nanometer scale features in a workpiece. According to one aspect, a system for producing nanometer scale features in a workpiece is disclosed. The system includes a die having a surface with at least one nanometer scale feature located thereon. A first actuator moves the die with respect to the workpiece such that the at least one nanometer scale feature impacts the workpiece and imprints a corresponding at least one nanometer scale feature in the workpiece.
FILED	Friday, January 05, 2018
APPL NO	15/863849
ART UNIT	3725 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 31/005 (20130101) B21D 31/06 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/424 (20130101) B29C 33/3878 (20130101) B29C 59/022 (20130101) Original (OR) Class B29C 2059/023 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2995/0018 (20130101) B29K 2995/0093 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2011/00 (20130101) B29L 2031/7562 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 99/0025 (20130101) B81C 2201/0153 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/02325 (20130101)
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10737933 — Flush-mount micromachined transducers

US 10737933	Reagan et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Tiffany N. Reagan (Gainesville, Florida); Mark Sheplak (Gainesville, Florida); Dylan P. Alexander (Gainesville, Florida)
ABSTRACT	Flush mount sensor packages and packaging methods for micromachined transducers, which can be used for fluid flow measurements, are provided. A sensor package can include a substrate, a sensor mounted on a front side of the substrate, a wire bond coupled to the sensor and passing through the substrate, and a shim cap positioned around the sensor. The wire bond does not protrude above the topside of the sensor, and the shim cap and the sensor can be substantially flush.
FILED	Tuesday, March 28, 2017
APPL NO	16/084706
ART UNIT	2898 — Semiconductors/Memory
CURRENT CPC	Microstructural Devices or Systems, e.g Micromechanical Devices B81B 7/02 (20130101) B81B 7/0006 (20130101) B81B 7/007 (20130101) Original (OR) Class B81B 2201/0257 (20130101) B81B 2201/0264 (20130101) B81B 2207/096 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00301 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 3/005 (20130101) H04R 17/02 (20130101) H04R 19/04 (20130101) H04R 19/005 (20130101) H04R 2201/003 (20130101) H04R 2499/13 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10737960 — Methods of synthesizing three-dimensional heteroatom-doped carbon nanotube macro materials and compositions thereof

US 10737960	Hashim et al.
FUNDED BY	National Science Foundation (NSF) Office of The Director (OD) Office of International Science and Engineering (OISE)
APPLICANT(S)	CSS Nanotech, Inc. (Houston, Texas)
ASSIGNEE(S)	CSS Nanotech, Inc. (Houston, Texas)
INVENTOR(S)	Daniel Hashim (Houston, Texas); Pulickel M. Ajayan (Houston, Texas); Mauricio Terrones (State College, Pennsylvania)
ABSTRACT	Methods for synthesizing macroscale 3D heteroatom-doped carbon nanotube materials (such as boron doped carbon nanotube materials) and compositions thereof. Macroscopic quantities of three-dimensionally networked heteroatom-doped carbon nanotube materials are directly grown using an aerosol-assisted chemical vapor deposition method. The porous heteroatom-doped carbon nanotube material is created by doping of heteroatoms (such as boron) in the nanotube lattice during growth, which influences the creation of elbow joints and branching of nanotubes leading to the three dimensional super-structure. The super-hydrophobic heteroatom-doped carbon nanotube sponge is strongly oleophilic and can soak up large quantities of organic solvents and oil. The trapped oil can be burnt off and the heteroatom-doped carbon nanotube material can be used repeatedly as an oil removal scaffold. Optionally, the heteroatom-doped carbon nanotubes in the heteroatom-doped carbon nanotube materials can be welded to form one or more macroscale 3D carbon nanotubes.
FILED	Tuesday, September 24, 2019
APPL NO	16/581064
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/205 (20130101) B01J 20/0248 (20130101) B01J 20/0259 (20130101) B01J 20/0266 (20130101) B01J 2220/42 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/16 (20170801) C01B 35/00 (20130101) C01B 2202/30 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/281 (20130101) C02F 1/283 (20130101) C02F 1/288 (20130101) C02F 1/681 (20130101) Original (OR) Class C02F 2101/32 (20130101) C02F 2103/007 (20130101) C02F 2103/08 (20130101) C02F 2305/08 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/32 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 10/37 (20150501)
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10738085 — Antimicrobial analogues of Gramicidin S

US 10738085	Del Valle et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Juan R. Del Valle (Tampa, Florida); Lindsey Shaw (Tampa, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida)
INVENTOR(S)	Juan R. Del Valle (Tampa, Florida); Lindsey Shaw (Tampa, Florida)
ABSTRACT	Disclosed herein are N-aminated variants of Gramicidin S and methods of using the same for treating infections in a subject.
FILED	Friday, May 31, 2019
APPL NO	16/428469
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/10 (20180101) Peptides C07K 7/66 (20130101) Original (OR) Class
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10738151 — Biorenewable, water-degradable polymers and co-polymers

US 10738151	Miller et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
INVENTOR(S)	Stephen Albert Miller (Gainesville, Florida); Pengxu Qi (Gainesville, Florida)
ABSTRACT	Various embodiments relate to biorenewable and water-degradable co-polymers and methods of producing co-polymers that include a plurality of first monomeric units and a plurality of second monomeric units joined by a plurality of hydrolytically-sensitive ester linkages. Each of the plurality of first monomeric units may be derived from a first monomer. The first monomer may be the product of a reaction between itaconic acid and a first amino acid. Each of the plurality of second monomeric units may be derived from a second monomer. The second monomer may be the product of a reaction between itaconic acid and a second amino acid. The co-polymers may be a product of the reaction of the first monomer and the second monomer in the presence of a diol. The co-polymers may have a glass transition temperature of about 50° C. or greater.
FILED	Monday, June 25, 2018
APPL NO	16/017076
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/6852 (20130101) C08G 63/6856 (20130101) Original (OR) Class C08G 2230/00 (20130101)
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10738153 — Ring-opening polymerizations using a flow reactor

US 10738153	Park et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York); The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California)
INVENTOR(S)	Nathaniel H. Park (San Jose, California); James L. Hedrick (Pleasanton, California); Victoria A. Piunova (Los Gatos, California); Dmitry Zubarev (San Jose, California); Gavin O. Jones (San Jose, California); Robert M. Waymouth (Palo Alto, California); Binhong Lin (Stanford, California)
ABSTRACT	Techniques regarding the synthesis of one or more polymers through one or more ring-opening polymerizations conducted within a flow reactor and facilitated by one or more anionic catalysts are provided. For example, one or more embodiments can comprise a method, which can comprise functionalizing, via a post-polymerization reaction within a flow reactor, a chemical compound by covalently bonding a trimethylsilyl protected thiol to a pendent functional group of the chemical compound in a presence of a catalyst. The pendent functional group can comprise a perfluoroaryl group and a methylene group.
FILED	Friday, July 06, 2018
APPL NO	16/029025
ART UNIT	1764 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 64/085 (20130101) Original (OR) Class
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10738239 — Mixed anion cesium rare earth silicates

US 10738239	zur Loye et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	University of South Carolina (Columbia, South Carolina)
ASSIGNEE(S)	University of South Carolina (Columbia, South Carolina)
INVENTOR(S)	Hans-Conrad zur Loye (Columbia, South Carolina); Allison M. Latshaw (Reading, Pennsylvania); Gregory Morrison (Columbia, South Carolina)
ABSTRACT	Scintillating compounds, methods of synthesizing scintillating compounds, and applications of scintillating compounds are disclosed. The scintillating compounds can include cesium rare earth silicates. A scintillating compound can include cesium, silicon, oxygen, fluorine, and one or more of europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium and scandium. The scintillating compounds can form unit cells having the general formula Cs₃RESi₄O₁₀F₂with RE including rare earth metals, lanthanides, and transition metals.
FILED	Tuesday, November 14, 2017
APPL NO	15/811939
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7774 (20130101) C09K 11/7792 (20130101) Original (OR) Class Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 9/12 (20130101) C30B 29/10 (20130101) C30B 29/12 (20130101)
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10738276 — Methods and kits for directing cell attachment and spreading

US 10738276	Yang
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Shengyuan Yang (West Melbourne, Florida)
ASSIGNEE(S)
INVENTOR(S)	Shengyuan Yang (West Melbourne, Florida)
ABSTRACT	The present disclosure provides methods, and related kits, for directing cell attachment and spreading on a substrate and inducing isotropic spreading of cells; provides methods, and related kits, for cell sorting; and further provides methods, and related kits, for guided induction of stem cell differentiation.
FILED	Tuesday, July 18, 2017
APPL NO	15/652921
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class C12N 5/0068 (20130101) C12N 5/0075 (20130101) C12N 5/0603 (20130101) C12N 5/0653 (20130101) C12N 5/0654 (20130101) C12N 5/0655 (20130101) C12N 5/0656 (20130101) C12N 5/0663 (20130101) C12N 2506/1384 (20130101) C12N 2531/00 (20130101) C12N 2533/12 (20130101) C12N 2533/30 (20130101) C12N 2535/00 (20130101)
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10738756 — Wave energy converter

US 10738756	Yang
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Yingchen Yang (Edinburg, Texas)
ASSIGNEE(S)	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Yingchen Yang (Edinburg, Texas)
ABSTRACT	Certain embodiments are directed to a vertical axis unidirectional rotor for wave energy conversion, said rotor comprising a plurality of spatially distributed lift-type and/or drag-type blades and a shaft, said rotor performing unidirectional rotation in waves about the shaft that is vertically oriented.
FILED	Wednesday, September 21, 2016
APPL NO	15/301823
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Machines or Engines for Liquids F03B 13/10 (20130101) F03B 13/183 (20130101) Original (OR) Class Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2220/7066 (20130101) F05B 2240/24 (20130101) F05B 2240/30 (20130101) F05B 2240/40 (20130101) F05B 2240/97 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/38 (20130101)
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10738757 — Variable displacement pump-motor

US 10738757	Rannow et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regetns of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Michael Rannow (Minneapolis, Minnesota); Perry Yan-Ho Li (Plymouth, Minnesota); Thomas Chase (Minneapolis, Minnesota)
ABSTRACT	A variable displacement pump-motor includes a pump-motor having a plurality of cylinders and pistons, and further including a main shaft rotatable relative to the system body. A hydro mechanical control system includes a plurality of main stage valves in communication with the plurality of cylinders. Each of the main stage valves is configured to open and close a cylinder of the plurality of cylinders to one or more of high or low pressure fluid sources. A pilot spool valve is in selective communication with each of the main stage valves. The pilot spool rotates with the main shaft. The pilot spool includes coding configured to operate each of the main stage valves to open and close the respective cylinders to the one or more high and low pressure fluid sources according to a translational position of the pilot spool and rotation of the pilot spool by the main shaft.
FILED	Sunday, December 04, 2016
APPL NO	15/368643
ART UNIT	3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Positive-displacement Engines Driven by Liquids F03C 1/0613 (20130101) F03C 1/0615 (20130101) F03C 1/0626 (20130101) F03C 1/0628 (20130101) F03C 1/0631 (20130101) F03C 1/0681 (20130101) Original (OR) Class Positive-displacement Machines for Liquids; Pumps F04B 1/16 (20130101) F04B 1/28 (20130101) F04B 1/143 (20130101) F04B 1/145 (20130101) F04B 1/146 (20130101) F04B 7/008 (20130101) F04B 53/10 (20130101)
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10739305 — Biosensing systems and methods using a FET

US 10739305	Bhansali et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Shekhar Bhansali (Weston, Florida); Syed Khalid Pasha (Miami, Florida); Mubarak Ajmuddin Mujawar (Miami, Florida)
ASSIGNEE(S)	The Florida International University Board of Trustees (Miami, Florida)
INVENTOR(S)	Shekhar Bhansali (Weston, Florida); Syed Khalid Pasha (Miami, Florida); Mubarak Ajmuddin Mujawar (Miami, Florida)
ABSTRACT	Systems and methods for sensing analytes using an extended gate field effect transistor (EGFET) are provided. A biosensing system can utilize a biodetection layer on a substrate, which can be coupled to a field effect transistor (FET). The coupling can be such that the gate of the field effect transistor is connected to the substrate having the biodetection layer thereon. The functionalized substrate can include a well-defined area that can hold a specific, pre-determined volume of fluid on top of it. An external electrode can be dipped in the fluid and can then be connected to a power source supplying a gate voltage. The presence or concentration of the target analyte in the fluid can be determined based on the source-drain characteristics of the FET.
FILED	Thursday, October 31, 2019
APPL NO	16/669621
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4145 (20130101) Original (OR) Class
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10739340 — Methods and compositions for enhancing immunoassays

US 10739340	Bailey et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Ryan C. Bailey (Urbana, Illinois); Matthew S. Luchansky (Allison Park, Pennsylvania); Abraham J. Qavi (Champaign, Illinois); Jared T. Kindt (Champaign, Illinois)
ABSTRACT	Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays.
FILED	Friday, April 27, 2018
APPL NO	15/964899
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54373 (20130101) Original (OR) Class G01N 2333/55 (20130101) G01N 2333/5412 (20130101)
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10739728 — Molecular clock

US 10739728	Han et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Ruonan Han (Winchester, Massachusetts); Cheng Wang (Cambridge, Massachusetts)
ABSTRACT	A molecular clock which utilizes a rotational spectrum of gaseous molecules in a sub-THz region for clock stabilization is described. The molecular clock has a fast start-up characteristic and is also robust against mechanical vibration or variation of electromagnetic field. Also described is a chip-scale implementation of a molecular clock. In an embodiment, a molecular clock chipset only consumes a DC power of 66 mW. While providing a highly stable, compact and energy efficient time generator of portable devices.
FILED	Thursday, December 27, 2018
APPL NO	16/233982
ART UNIT	2849 — Optics
CURRENT CPC	Time-interval Measuring G04F 5/14 (20130101) G04F 5/145 (20130101) Original (OR) Class Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 17/00 (20130101) Tuning Resonant Circuits; Selecting Resonant Circuits H03J 7/00 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) H03L 7/0992 (20130101) H03L 7/1976 (20130101) Transmission H04B 1/18 (20130101) H04B 1/30 (20130101) H04B 1/1027 (20130101)
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10739853 — Method and apparatus for finger position tracking and haptic display using conductive islands

US 10739853	Colgate et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	James E Colgate (Evanston, Illinois); Michael A Peshkin (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	James E Colgate (Evanston, Illinois); Michael A Peshkin (Evanston, Illinois)
ABSTRACT	A touchscreen includes conductive islands that are capacitively coupled to conductive traces, where they may be used to provide capacitive sensing of the position of one or more fingers in contact with a touchscreen and/or to exert haptic forces on one or more fingers in contact with a touchscreen.
FILED	Thursday, June 09, 2016
APPL NO	15/178283
ART UNIT	2623 — Selective Visual Display Systems
CURRENT CPC	Electric Digital Data Processing G06F 3/016 (20130101) Original (OR) Class G06F 3/044 (20130101) G06F 3/0416 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 21/003 (20130101)
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10740371 — Systems and methods for intelligently configuring and deploying a machine learning-based dialogue system

US 10740371	Mars et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Clinc, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)	Clinc, Inc. (Ann Arbor, Michigan)
INVENTOR(S)	Jason Mars (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan); Parker Hill (Ann Arbor, Michigan); Yiping Kang (Ann Arbor, Michigan); Yunqi Zhang (Ann Arbor, Michigan)
ABSTRACT	A system and method for intelligently configuring a machine learning-based dialogue system includes a conversational deficiency assessment of a target dialog system, wherein implementing the conversational deficiency assessment includes: (i) identifying distinct corpora of mishandled utterances based on an assessment of the distinct corpora of dialogue data; (ii) identifying candidate corpus of mishandled utterances from the distinct corpora of mishandled utterances as suitable candidates for building new dialogue competencies for the target dialogue system if candidate metrics of the candidate corpus of mishandled utterances satisfy a candidate threshold; building the new dialogue competencies for the target dialogue system for each of the candidate corpus of mishandled utterances having candidate metrics that satisfy the candidate threshold; and configuring a dialogue system control structure for the target dialogue system based on the new dialogue competencies, wherein the dialogue system control structure governs an operation of an automated dialogue agent.
FILED	Wednesday, October 30, 2019
APPL NO	16/668559
ART UNIT	2659 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 16/3329 (20190101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6215 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101)
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10740465 — Detection of print-based spoofing attacks

US 10740465	Komogortsev
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Texas State University (San Marcos, Texas)
ASSIGNEE(S)	Texas State University San Marcos (San Marcos, Texas)
INVENTOR(S)	Oleg V. Komogortsev (Austin, Texas)
ABSTRACT	A method of assessing the possibility of an iris print-attack includes measurement of the eye movement of a person. One or more values (e.g., a feature vector) are determined based on the measured eye movements. Based on the determined values, an assessment is made of whether or not the person is engaging in an iris print-attack.
FILED	Monday, December 07, 2015
APPL NO	15/533191
ART UNIT	2431 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/32 (20130101) G06F 21/566 (20130101) Original (OR) Class G06F 2221/031 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0061 (20130101) G06K 9/00906 (20130101)
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10740686 — Stochastic computation using pulse-width modulated signals

US 10740686	Najafi et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Mohammadhassan Najafi (Minneapolis, Minnesota); Shiva Jamalizavareh (Minneapolis, Minnesota); David J. Lilja (Maplewood, Minnesota); Marcus Riedel (Minneapolis, Minnesota); Kiarash Bazargan (Plymouth, Minnesota); Ramesh Harjani (Minneapolis, Minnesota)
ABSTRACT	Devices and techniques are described in which stochastic computation is performed on analog periodic pulse signals instead of random, stochastic digital bit streams. Exploiting pulse width modulation (PWM), time-encoded signals corresponding to specific values are generated by adjusting the frequency (period) and duty cycles of PWM signals. With this approach, the latency, area, and energy consumption are all greatly reduced, as compared to prior stochastic approaches. Circuits synthesized with the proposed approach can work as fast and energy efficiently as a conventional binary design while retaining the fault-tolerance and low-cost advantages of conventional stochastic designs.
FILED	Friday, January 12, 2018
APPL NO	15/869453
ART UNIT	2182 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 7/582 (20130101) Hybrid Computing Arrangements G06J 1/00 (20130101) Computer Systems Based on Specific Computational Models G06N 3/0472 (20130101) G06N 7/005 (20130101) Original (OR) Class Pulse Technique H03K 7/08 (20130101)
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10740880 — Systems and methods for analyzing pathologies utilizing quantitative imaging

US 10740880	Paik et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	ELUCID BIOIMAGING INC. (Boston, Massachusetts)
ASSIGNEE(S)	ELUCID BIOIMAGING INC. (Boston, Massachusetts)
INVENTOR(S)	David S. Paik (Half Moon Bay, California); Andrew J. Buckler (Wenham, Massachusetts); Kjell Johnson (Ann Arbor, Michigan); Xiaonan Ma (South Hamilton, Massachusetts); Keith A. Moulton (Amesbury, Massachusetts)
ABSTRACT	The present disclosure provides for improved image analysis via novel deblurring and segmentation techniques of image data. These techniques advantageously account for and incorporate segmentation of biological analytes into a deblurring process for an image. Thus, the deblurring of the image may advantageously be optimized for enabling identification and quantitative analysis of one or more biological analytes based on underlying biological models for those analytes. The techniques described herein provide for significant improvements in the image deblurring and segmentation process which reduces signal noise and improves the accuracy of the image. In particular, the system and methods described herein advantageously utilize unique optimization and tissue characteristics image models which are informed by the underlying biology being analyzed, (for example by a biological model for the analytes). This provides for targeted deblurring and segmentation which is optimized for the applied image analytics.
FILED	Thursday, January 18, 2018
APPL NO	15/874474
ART UNIT	2666 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/34 (20130101) G06K 9/621 (20130101) G06K 9/4647 (20130101) G06K 2209/05 (20130101) Image Data Processing or Generation, in General G06T 5/003 (20130101) Original (OR) Class G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 7/136 (20170101) G06T 7/143 (20170101) G06T 7/194 (20170101) G06T 2207/10072 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10132 (20130101) G06T 2207/20036 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20152 (20130101) G06T 2207/20161 (20130101) G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) G06T 2207/30101 (20130101)
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10741399 — Femtosecond laser-induced formation of submicrometer spikes on a semiconductor substrate

US 10741399	Mazur et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S)	Eric Mazur (Concord, Massachusetts); Mengyan Shen (Belmont, Massachusetts)
ABSTRACT	The present invention generally provides semiconductor substrates having submicron-sized surface features generated by irradiating the surface with ultra short laser pulses. In one aspect a method of processing a semiconductor substrate is disclosed that includes placing at least a portion of a surface of the substrate in contact with a fluid, and exposing that surface portion to one or more femtosecond pulses so as to modify the topography of that portion. The modification can include, e.g., generating a plurality of submicron-sized spikes in an upper layer of the surface.
FILED	Wednesday, February 14, 2018
APPL NO	15/896940
ART UNIT	2819 — Semiconductors/Memory
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/1224 (20151001) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0259 (20130101) H01L 21/268 (20130101) Original (OR) Class H01L 21/302 (20130101) H01L 21/2252 (20130101) H01L 21/02381 (20130101) H01L 21/02532 (20130101) H01L 21/02686 (20130101) H01L 21/67075 (20130101) H01L 29/30 (20130101) H01L 29/34 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 438/94 (20130101)
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10741649 — High mobility doped metal oxide thin films and reactive physical vapor deposition methods of fabricating the same

US 10741649	Sachet et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF)
APPLICANT(S)	North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)	NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
INVENTOR(S)	Edward Sachet (Raleigh, North Carolina); Christopher Shelton (Raleigh, North Carolina); Jon-Paul Maria (Raleigh, North Carolina); Kyle Patrick Kelley (Lake Lure, North Carolina); Evan Lars Runnerstrom (Durham, North Carolina)
ABSTRACT	A method of forming a metal oxide includes providing a reactive deposition atmosphere having an oxygen concentration of greater than about 20 percent in a chamber including a substrate therein. A pulsed DC signal is applied to a sputtering target comprising a metal, to sputter metal particles therefrom. A doping element may be supplied from a doping source (such as an alloyed metal target) in the reaction chamber. An electrically conductive metal oxide film comprising an oxide of the metal is deposited on the substrate responsive to a reaction between the metal particles and the reactive deposition atmosphere. Related devices are also discussed.
FILED	Thursday, May 24, 2018
APPL NO	15/988883
ART UNIT	2811 — Semiconductors/Memory
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/35 (20130101) C23C 14/0042 (20130101) C23C 14/0057 (20130101) C23C 14/086 (20130101) C23C 14/345 (20130101) C23C 14/352 (20130101) C23C 14/548 (20130101) C23C 14/3485 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/477 (20130101) H01L 21/02266 (20130101) H01L 29/45 (20130101) H01L 29/267 (20130101) Original (OR) Class H01L 29/458 (20130101) H01L 29/7869 (20130101) H01L 31/022466 (20130101)
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10741705 — Optoelectronic device having an antireflective surface

US 10741705	Li et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Xiuling Li (Champaign, Illinois); Jeong Dong Kim (Savoy, Illinois); Munho Kim (Champaign, Illinois)
ABSTRACT	An optoelectronic device with an antireflective surface comprises a semiconductor substrate having a textured surface including a plurality of surface protrusions and/or indentations. A first electrode is in contact with the semiconductor substrate and spaced apart from a second electrode that is also in contact with the semiconductor substrate. The textured surface is fabricated by inverse metal-assisted chemical etching, and thus the semiconductor substrate is substantially devoid of ion-induced defects.
FILED	Friday, July 13, 2018
APPL NO	16/034774
ART UNIT	2891 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/032 (20130101) H01L 31/108 (20130101) H01L 31/02327 (20130101) Original (OR) Class H01L 31/02363 (20130101) H01L 31/022408 (20130101)
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10741719 — Quantum dot channel (QDC) quantum dot gate transistors, memories and other devices

US 10741719	Jain
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Electrical and Communications Systems (ECS)
APPLICANT(S)	Faquir Chand Jain (Storrs, Connecticut)
ASSIGNEE(S)
INVENTOR(S)	Faquir Chand Jain (Storrs, Connecticut)
ABSTRACT	This CIP application builds on Ge quantum dot superlattice (QDSL) based field effect transistors where Ge quantum dot arrays are used as a high carrier mobility channel. The QDSL diodes claims that were withdrawn are included. The diodes are used as light emitting devices and photodetectors. A combination of QDC-FETs, light emitting devise, photodetectors are vertically stacked to form a versatile 3-dimensional integrated circuit. Nonvolatile memories using floating quantum dot gates are included in vertical stacking format. Nonvolatile random access memories are integrated as a stack. Also described is the use of 3-layer stack of QDC-FETs making compact electrical circuits interfacing pixels for an active matrix flat panel displays that results in high resolution. Ge or Si quantum dot transport channel based devices processing spin polarized electrons introduced by magnetic tunnel junctions are described for multi-state coherent logic.
FILED	Tuesday, August 15, 2017
APPL NO	15/677498
ART UNIT	2899 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/15 (20130101) H01L 29/16 (20130101) H01L 29/20 (20130101) H01L 29/127 (20130101) H01L 29/0665 (20130101) H01L 29/0673 (20130101) H01L 29/775 (20130101) H01L 29/788 (20130101) H01L 29/1033 (20130101) H01L 29/4234 (20130101) H01L 29/7613 (20130101) H01L 29/40114 (20190801) H01L 29/40117 (20190801) H01L 29/42324 (20130101) H01L 29/66825 (20130101) H01L 33/06 (20130101) Original (OR) Class H01L 33/08 (20130101) H01L 33/18 (20130101) H01L 33/28 (20130101) H01L 33/34 (20130101)
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10741744 — Switchable superconducting Josephson junction device for low energy information storage and processing

US 10741744	Moodera et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusets Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Jagadeesh S. Moodera (Somerville, Massachusetts); Juan Pedro Cascales Sandoval (Somerville, Massachusetts); Yota Takamura (Cambridge, Massachusetts)
ABSTRACT	A switchable Josephson junction is provided that includes a plurality of ferromagnetic insulators that are defined by their respective magnetic alignments. A first superconducting layer that is positioned between any two of the ferromagnetic insulators, wherein the conductive state is controlled by the relative magnetization orientation of the ferromagnetic insulators where the first superconducting layer is superconducting when the two magnetizations are aligned in antiparallel but it turns normally conducting when the magnetic alignment is parallel. A second superconducting layer is adjacent one of the ferromagnetic layers, wherein Josephson tunneling occurs between the first superconducting layer and second superconducting layer across one of the ferromagnetic layers.
FILED	Monday, September 24, 2018
APPL NO	16/139938
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/10 (20130101) H01L 39/16 (20130101) H01L 39/025 (20130101) H01L 39/121 (20130101) H01L 39/223 (20130101) Original (OR) Class
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10741759 — Diffusive memristor and device for synaptic emulator

US 10741759	Yang et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Air Force Research Laboratory (AFRL) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Jianhua Yang (Hadley, Massachusetts); Qiangfei Xia (Amherst, Massachusetts); Mark McLean (Severna Park, Maryland); Qing Wu (Manilus, New York); Mark Barnell (Clay, New York)
ABSTRACT	A diffusive memristor device and an electronic device for emulating a biological synapse are disclosed. The diffusive memristor device includes a bottom electrode, a top electrode formed opposite the bottom electrode, and a dielectric layer disposed between the top electrode and the bottom electrode. The dielectric layer comprises silver doped silicon oxynitride (SiO_xN_y:Ag). In an alternate implementation, the dielectric layer comprises silver doped silicon oxide (Ag:SiO₂). An electronic synapse emulation device is also disclosed. The synapse emulation device includes a diffusive memristor device, a drift memristor device connected in series with the diffusive memristor device, a first voltage pulse generator connected to the diffusive memristor device, and a second voltage pulse generator connected to the drift memristor device. Application of a signal from one of the first voltage pulse generator or the second voltage pulse generator allows the synapse emulation device to exhibit long-term plasticity.
FILED	Wednesday, September 26, 2018
APPL NO	16/142310
ART UNIT	2896 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/085 (20130101) H01L 45/145 (20130101) H01L 45/146 (20130101) H01L 45/1233 (20130101) H01L 45/1253 (20130101) H01L 45/1266 (20130101) Original (OR) Class
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Department of Energy (DOE)

10736992 — Biomolecular patterning of three dimensional tissue scaffolds

US 10736992	Bailey et al.
FUNDED BY	Department of Energy (DOE) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Ryan C. Bailey (Urbana, Illinois); Brendan A. Harley (Urbana, Illinois); Teresa A. Martin (Champaign, Illinois); Steven R. Caliari (Urbana, Illinois)
ASSIGNEE(S)	BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Ryan C. Bailey (Urbana, Illinois); Brendan A. Harley (Urbana, Illinois); Teresa A. Martin (Champaign, Illinois); Steven R. Caliari (Urbana, Illinois)
ABSTRACT	The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.
FILED	Monday, February 27, 2012
APPL NO	14/001327
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/32 (20130101) A61K 38/30 (20130101) A61K 38/1858 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/26 (20130101) A61L 27/38 (20130101) Original (OR) Class A61L 27/48 (20130101) A61L 27/48 (20130101) A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 2430/02 (20130101) A61L 2430/06 (20130101) A61L 2430/20 (20130101) A61L 2430/28 (20130101) A61L 2430/30 (20130101) A61L 2430/32 (20130101) A61L 2430/40 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0063 (20130101) Compositions of Macromolecular Compounds C08L 89/06 (20130101) C08L 89/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0654 (20130101) C12N 5/0655 (20130101) C12N 5/0657 (20130101) C12N 5/0658 (20130101) C12N 2533/54 (20130101)
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10737128 — Ultra-breathable and protective membranes with sub-5 nm carbon nanotube pores

US 10737128	Fornasiero et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Securing, LLC (Livermore, California)
INVENTOR(S)	Francesco Fornasiero (Oakland, California); Kuang Jen J. Wu (Cupertino, California); Sangil Kim (Chicago, Illinois)
ABSTRACT	In one embodiment, a product includes a plurality of carbon nanotubes and a fill material in interstitial spaces between the carbon nanotubes for limiting or preventing fluidic transfer between opposite sides of the product except through interiors of the carbon nanotubes. Moreover, the longitudinal axes of the carbon nanotubes are substantially parallel, where an average inner diameter of the carbon nanotubes is about 20 nanometers or less. In addition, the ends of the carbon nanotubes are open and the fill material is impermeable or having an average porosity that is less than the average inner diameter of the carbon nanotubes.
FILED	Thursday, February 23, 2017
APPL NO	15/441153
ART UNIT	1786 — Miscellaneous Articles, Stock Material
CURRENT CPC	Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 5/00 (20130101) Original (OR) Class Separation B01D 67/0034 (20130101) B01D 67/0037 (20130101) B01D 67/0041 (20130101) B01D 67/0079 (20130101) B01D 69/02 (20130101) B01D 69/148 (20130101) B01D 71/021 (20130101) B01D 71/28 (20130101) B01D 2325/20 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) C23C 16/045 (20130101) C23C 16/56 (20130101) C23C 16/4418 (20130101)
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10737225 — Nested bubbling apparatus

US 10737225	Baxter et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	Larry Baxter (Orem, Utah); Jacom Chamberlain (Provo, Utah); Kyler Stitt (Lindon, Utah); David Frankman (Provo, Utah); Christopher Bence (Tigard, Oregon); Aaron Sayre (Spanish Fork, Utah)
ASSIGNEE(S)	Hall Labs LLC (Provo, Utah)
INVENTOR(S)	Larry Baxter (Orem, Utah); Jacom Chamberlain (Provo, Utah); Kyler Stitt (Lindon, Utah); David Frankman (Provo, Utah); Christopher Bence (Tigard, Oregon); Aaron Sayre (Spanish Fork, Utah)
ABSTRACT	A device for bubbling a gas into a liquid is disclosed. The device comprises a first bubbling apparatus nested inside a second bubbling apparatus. The first bubbling apparatus comprises a gas inlet for receiving the gas and a plurality of first openings for releasing the gas. The second bubbling apparatus at least partially encloses the plurality of first openings of the first bubbling apparatus. The second bubbling apparatus receives the gas from the plurality of first openings. The second bubbling apparatus comprises a plurality of second openings for bubbling the gas into the liquid.
FILED	Monday, October 09, 2017
APPL NO	15/727817
ART UNIT	1774 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 3/18 (20130101) B01D 5/003 (20130101) Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 3/04248 (20130101) B01F 3/04262 (20130101) Original (OR) Class B01F 2003/04297 (20130101) B01F 2003/04312 (20130101) B01F 2003/04319 (20130101)
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10737261 — Reversibly bonded devices and methods of making and using the same

US 10737261	Nath et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Pulak Nath (Los Alamos, New Mexico); Jen-Huang Huang (Los Alamos, New Mexico)
ABSTRACT	The present disclosure concerns embodiments of reversibly bonded devices that comprise a reversible bonding component. The reversible bonding component is able to exhibit strong adhesive properties so as to couple device components, but upon exposure to an energy source, the strong adhesive properties are weakened. By weakening the adhesive strength of the reversible bonding component, the device can be deconstructed to access internal biological samples for analysis and characterization.
FILED	Thursday, September 28, 2017
APPL NO	15/719187
ART UNIT	1799 — Fluid Handling and Dispensing
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2300/0681 (20130101) B01L 2300/0816 (20130101) B01L 2300/0887 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101)
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10737324 — System and method for forming material substrate printer

US 10737324	Demuth et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	James A. Demuth (Mountain View, California); Andrew Bayramian (Manteca, California); Bassem S. El-Dasher (Livermore, California); Kevin J. Kramer (Pleasanton, California)
ABSTRACT	A method is disclosed for manufacturing a part via an additive manufacturing process. A solution is used which has a volatile component within which is suspended particles of a powdered material. The solution is heated until it at least one of begins boiling or is about to begin boiling. The heated solution is then deposited at least at one location on a substrate to help form a layer of the part. The volatile component then evaporates, leaving only the particles of powdered material. The particles are then heated to the melting point. The deposition and heating operations are repeated to successively form a plurality of layers for the part. The evaporation of the volatile component helps to cool the part.
FILED	Thursday, October 02, 2014
APPL NO	14/504646
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0074 (20130101) B22F 3/1055 (20130101) Original (OR) Class B22F 2003/1056 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) B29C 64/165 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/295 (20151101)
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10737948 — Polar oxysulfide for nonlinear optical applications

US 10737948	Zur Loye et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	University of South Carolina (Columbia, South Carolina); National Institute For Materials Science (Tsukuba-shi, Ibaraki, Japan)
ASSIGNEE(S)	University of South Carolina (Columbia, South Carolina)
INVENTOR(S)	Hans-Conrad Zur Loye (Columbia, South Carolina); Yoshihiro Tsujimoto (Ibaraki, Japan)
ABSTRACT	Single crystals of a new noncentrosymmetric polar oxysulfide SrZn₂S₂O (s.g. Pmn2₁) grown in a eutectic KF—KCl flux with unusual wurtzite-like slabs consisting of close-packed corrugated double layers of ZnS₃O tetrahedra vertically separated from each other by Sr atoms and methods of making same.
FILED	Thursday, September 05, 2019
APPL NO	16/561190
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2/22 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 9/006 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/20 (20130101) C01P 2002/72 (20130101) C01P 2002/76 (20130101) C01P 2002/77 (20130101) C01P 2002/78 (20130101) C01P 2006/37 (20130101) C01P 2006/40 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/37 (20130101) G02F 1/3551 (20130101)
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10738090 — Engineered microcompartment protein and related methods and systems of engineering bacterial systems for non-native protein expression and purification

US 10738090	Yung et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California); The Regents of the University of California (Oakland, California)
INVENTOR(S)	Mimi Cho Yung (Milpitas, California); Timothy S. Carpenter (Livermore, California); Tek Hyung Lee (Pleasanton, California); David Savage (Berkeley, California)
ABSTRACT	Engineered microcompartment proteins, and related engineered microcompartment, vectors, cells compositions, methods and systems configured to provide within a cell one or more proteins non-native to the cell are described, wherein the one or more proteins non-native to the cell are contained in at least one engineered microcompartment within the cell.
FILED	Thursday, December 13, 2018
APPL NO	16/219781
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/195 (20130101) Original (OR) Class C07K 14/43563 (20130101) C07K 14/43572 (20130101) C07K 2319/50 (20130101)
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10738202 — Porous thermally insulating compositions containing hollow spherical nanoparticles

US 10738202	Dai et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee); Virginia Tech (Blacksburg, Virginia)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee); Virginia Tech (Blacksburg, Virginia)
INVENTOR(S)	Sheng Dai (Knoxville, Tennessee); Jinshui Zhang (Oak Ridge, Tennessee); Xueguang Jiang (Johns Creek, Georgia); Shannon Mark Mahurin (Lenoir, Tennessee); Xiao-Guang Sun (Knoxville, Tennessee); Huimin Luo (Knoxville, Tennessee); Rui Qiao (Blacksburg, Virginia)
ABSTRACT	A method of thermally insulating a surface, the method comprising applying a coating of a thermally insulating composition onto said surface, wherein said thermally insulating composition comprises: (i) hollow spherical nanoparticles having a mean particle size of less than 800 nm in diameter and a particle size distribution in which at least 90% of the hollow spherical nanoparticles have a size within ±20% of said mean particle size, and a first layer of cationic or anionic molecules attached to said surfaces of the hollow spherical nanoparticles; and (ii) a second layer of molecules of opposite charge to the first layer of molecules, wherein said second layer of molecules of opposite charge are ionically associated with said first layer of molecules, wherein the molecules in said second layer have at least eight carbon atoms.
FILED	Wednesday, January 10, 2018
APPL NO	15/866630
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 31/77 (20130101) A61K 33/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) C08K 7/26 (20130101) C08K 9/06 (20130101) C08K 2201/003 (20130101) C08K 2201/011 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/00 (20130101) C09D 7/61 (20180101) C09D 7/62 (20180101) Original (OR) Class C09D 7/66 (20180101) C09D 7/70 (20180101) C09D 171/02 (20130101) Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 3/67 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 59/028 (20130101)
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10738333 — Production of itaconic acid and related molecules from aromatic compounds

US 10738333	Elmore et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee); Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee); ALLIANCE FOR SUSTAINABLE ENERGY, LLC (Golden, Colorado)
INVENTOR(S)	Joshua R. Elmore (Richland, Washington); Jay Huenemann (Knoxville, Tennessee); Davinia Salvachua (Golden, Colorado); Gregg T. Beckham (Golden, Colorado); Adam M. Guss (Knoxville, Tennessee)
ABSTRACT	This disclosure provides a genetically-modified bacterium from the genus Pseudomonas that produces itaconate or trans-aconitate. The disclosure further provides methods for producing itaconate or trans-aconitate using a genetically-modified bacterium from the genus Pseudomonas.
FILED	Monday, April 29, 2019
APPL NO	16/397256
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/88 (20130101) C12N 9/90 (20130101) C12N 9/1025 (20130101) C12N 15/74 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/44 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 1/38 (20130101) Enzymes C12Y 203/03001 (20130101) C12Y 401/01006 (20130101) C12Y 503/03007 (20130101)
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10738671 — Diagnostic methods for a high efficiency exhaust aftertreatment system

US 10738671	Gupta et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Cummins, Inc. (Columbus, Indiana)
ASSIGNEE(S)	Cummins, Inc. (Columbus, Indiana)
INVENTOR(S)	Aniket Gupta (Wuhan, China PRC); Michael J. Cunningham (Greenwood, Indiana); Michael Haas (Columbus, Indiana); Govindarajan Kothandaraman (Columbus, Indiana)
ABSTRACT	A method includes interpreting NOx data indicative of an amount of NOx exiting an engine and an amount of NOx exiting an exhaust aftertreatment system coupled to the engine, determining a NOx conversion efficiency fault is present based on the amount of NOx exiting the engine and the amount of NOx exiting the exhaust aftertreatment system, and determining at least one of a selective catalytic reduction (SCR) catalyst of the exhaust aftertreatment system and a diesel particulate filter having a coating of a SCR reaction catalyst (DPF-SCR) of the exhaust aftertreatment system are responsible for the NOx conversion efficiency fault based on at least one of a reductant slip amount and a NOx conversion value across at least one of the SCR catalyst and the DPF-SCR.
FILED	Wednesday, January 10, 2018
APPL NO	15/866776
ART UNIT	3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines F01N 3/035 (20130101) Original (OR) Class F01N 3/103 (20130101) F01N 3/0835 (20130101) F01N 3/0842 (20130101) F01N 3/2066 (20130101) F01N 11/00 (20130101) F01N 13/0093 (20140601) F01N 2550/02 (20130101) F01N 2560/06 (20130101) F01N 2560/14 (20130101) F01N 2560/021 (20130101) F01N 2560/026 (20130101) F01N 2610/02 (20130101) F01N 2900/1402 (20130101) F01N 2900/1616 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/24 (20130101) Y02T 10/47 (20130101)
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10739067 — Component removal from a gas stream

US 10739067	Baxter et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	Larry Baxter (Orem, Utah); Christopher Hoeger (Provo, Utah); Aaron Sayre (Spanish Fork, Utah); Jacom Chamberlain (Provo, Utah); Kyler Stitt (Lindon, Utah)
ASSIGNEE(S)	Hall Labs LLC (Provo, Utah)
INVENTOR(S)	Larry Baxter (Orem, Utah); Christopher Hoeger (Provo, Utah); Aaron Sayre (Spanish Fork, Utah); Jacom Chamberlain (Provo, Utah); Kyler Stitt (Lindon, Utah)
ABSTRACT	In a first aspect, the disclosure provides a method for removing a component from a gas stream. A carrier gas stream is cooled by direct contact with a dehydrating solution stream. The dehydrating solution stream removes a portion of water present in the carrier gas stream and produces a dry gas stream and a wet solution stream. A portion of the component is removed from the dry gas stream by direct contact with a cold contact liquid stream. A depleted gas stream and a slurry stream are produced. Removing the portion of the component may include desublimating, freezing, condensing, depositing, or a combination thereof of the portion of the component out of the dry gas stream as a solid product. The slurry stream may include the solid product and a contact liquid. The solid product is separated from the contact liquid, producing a substantially pure solid product stream and the cold contact liquid stream.
FILED	Tuesday, February 20, 2018
APPL NO	15/899719
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Separation B01D 3/14 (20130101) B01D 43/00 (20130101) B01D 53/14 (20130101) B01D 53/263 (20130101) B01D 2257/80 (20130101) B01D 2257/204 (20130101) B01D 2257/704 (20130101) B01D 2257/7022 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/044 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 39/04 (20130101) Liquefaction, Solidification or Separation of Gases or Gaseous Mixtures by Pressure and Cold Treatment F25J 3/08 (20130101) F25J 3/0219 (20130101) Original (OR) Class F25J 2240/82 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 1/0246 (20130101)
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10739087 — Article, component, and method of forming an article

US 10739087	Lacy et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
ASSIGNEE(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
INVENTOR(S)	Benjamin Paul Lacy (Greer, South Carolina); Sandip Dutta (Greenville, South Carolina); David Edward Schick (Greenville, South Carolina)
ABSTRACT	An article and method of forming an article are provided. The article includes a body portion separating an inner region and an outer region, an aperture in the body portion, the aperture fluidly connecting the inner region and the outer region, and a baffle extending along at least a portion of an inner surface of the article, the baffle dividing the inner region into a plurality of sub-regions. The method of forming an article includes forming a body portion defining an inner region and an outer region, forming an aperture in the body portion, the aperture fluidly connecting the inner region to the outer region, and forming at least one baffle extending along at least a portion of an inner surface of the body portion, the at least one baffle dividing the inner region into a plurality of sub-regions. Also provided is a component including a cooling article disposed therein.
FILED	Tuesday, September 08, 2015
APPL NO	14/847409
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/26 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/188 (20130101) F01D 5/189 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/22 (20130101) F05D 2260/201 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/06 (20130101) Original (OR) Class F28F 13/18 (20130101)
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10739089 — Bi-directional porous media phase change heat exchanger

US 10739089	McKay et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Ian Salmon McKay (Seattle, Washington); Shankar Narayanan (Chestnut Hill, Massachusetts); Evelyn N. Wang (Cambridge, Massachusetts)
ABSTRACT	Heat exchange structure. A hydrophilic, thermally conductive porous medium includes nanostructures formed substantially uniformly throughout the porous medium providing a balance of capillary and viscous forces to self-regulate a liquid-vapor contact line. A suitable porous medium is copper. A method for making the structure is also disclosed.
FILED	Thursday, March 27, 2014
APPL NO	14/227083
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/18 (20130101) Original (OR) Class F28F 19/02 (20130101) F28F 2245/00 (20130101)
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10739434 — Acoustic transmission device and process for tracking selected hosts

US 10739434	Deng et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Zhiqun Deng (Richland, Washington); Huidong Li (Richland, Washington); Jun Lu (Richland, Washington); Mitchell J. Myjak (Richland, Washington); Jayson J. Martinez (Richland, Washington); Jie Xiao (Richland, Washington); Richard S. Brown (Richland, Washington); Samuel S. Cartmell (Richland, Washington)
ABSTRACT	A new acoustic tag and process are disclosed for identifying and tracking underwater hosts in up to three dimensions. The acoustic tag has an operation lifetime up to a year or longer at a pulse rate interval of about 15 seconds. The acoustic tag has a signal detection range up to at least about 500 meters that enhances detection probability.
FILED	Wednesday, September 26, 2018
APPL NO	16/143273
ART UNIT	3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 11/006 (20130101) A01K 61/90 (20170101) Diagnosis; Surgery; Identification A61B 5/07 (20130101) A61B 5/0015 (20130101) A61B 5/1112 (20130101) A61B 2503/40 (20130101) A61B 2562/08 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 1/72 (20130101) Original (OR) Class G01S 5/18 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 17/00 (20130101) G06K 19/0728 (20130101) Transmission H04B 1/034 (20130101)
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10739609 — Jitter minimization flexure pointing system

US 10739609	Stromberg et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Peter G. Stromberg (Albuquerque, New Mexico); Patrick S. Barney (Albuquerque, New Mexico)
ABSTRACT	The illustrative embodiments provide for a telescope. The telescope includes a housing; an optical assembly disposed inside the housing and configured to gather light from a distant object; and a jitter reduction system connected to the housing. The jitter reduction system includes a first flexure assembly comprising a first base to which is attached to a first armature connected to a first linear motor winding configured to push out a first flexure connected to the first armature and to push out a second flexure connected to the first armature opposite the first flexure, wherein the first flexure and the second flexure have a first normal axis pointing through a center of mass of the optical assembly.
FILED	Wednesday, August 01, 2018
APPL NO	16/051570
ART UNIT	2872 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 23/16 (20130101) G02B 27/646 (20130101) Original (OR) Class
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10740003 — Latency-agnostic memory controller

US 10740003	Emma et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Philip G. Emma (Danbury, Connecticut); Michael B. Healy (Cortlandt Manor, New York); Tejas Karkhanis (White Plains, New York)
ABSTRACT	A computer-implemented method includes receiving, at a memory controller, a new transaction request referencing a new transaction to be executed on a memory. The memory includes two or more memory groups embodying two or more memory technologies, and the memory controller includes two or more group request queues with a respective group request queue corresponding to each memory group of the two or more memory groups. A memory group is selected, by the memory controller, from among the two or more memory groups. The transaction request is placed, by the memory controller, on the respective group request queue corresponding to the selected memory group. The new transaction is executed on the selected memory group. A new response to the new transaction is received, by the memory controller, from the selected memory group. The new response is returned.
FILED	Friday, March 23, 2018
APPL NO	15/933420
ART UNIT	2133 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 3/0611 (20130101) Original (OR) Class G06F 3/0658 (20130101) G06F 3/0659 (20130101) G06F 3/0685 (20130101)
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10740097 — Embedding global barrier and collective in a torus network

US 10740097	Chen et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Dong Chen (Croton on Hudson, New York); Paul W. Coteus (Yorktown, New York); Noel A. Eisley (Yorktown Heights, New York); Alan Gara (Mount Kisco, New York); Philip Heidelberger (Cortlandt Manor, New York); Robert M. Senger (Tarrytown, New York); Valentina Salapura (Chappaqua, New York); Burkhard Steinmacher-Burow (Esslingen, Germany); Yutaka Sugawara (White Plains, New York); Todd E. Takken (Mount Kisco, New York)
ABSTRACT	Embodiments of the invention provide a method, system and computer program product for embedding a global barrier and global interrupt network in a parallel computer system organized as a torus network. The computer system includes a multitude of nodes. In one embodiment, the method comprises taking inputs from a set of receivers of the nodes, dividing the inputs from the receivers into a plurality of classes, combining the inputs of each of the classes to obtain a result, and sending said result to a set of senders of the nodes. Embodiments of the invention provide a method, system and computer program product for embedding a collective network in a parallel computer system organized as a torus network. In one embodiment, the method comprises adding to a torus network a central collective logic to route messages among at least a group of nodes in a tree structure.
FILED	Friday, May 20, 2016
APPL NO	15/160766
ART UNIT	2454 — Computer Networks
CURRENT CPC	Electric Digital Data Processing G06F 9/3001 (20130101) G06F 9/30018 (20130101) G06F 9/30021 (20130101) Original (OR) Class G06F 9/30145 (20130101) G06F 11/348 (20130101) G06F 11/3024 (20130101) G06F 11/3409 (20130101) G06F 15/17362 (20130101) G06F 15/17381 (20130101) G06F 15/17393 (20130101) G06F 2201/88 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/10 (20130101)
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10740163 — Network packet templating for GPU-initiated communication

US 10740163	Hamidouche et al.
FUNDED BY	Department of Energy (DOE) Exascale Computing Project (ECP) PathForward Project (PATHFORWARD) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)	Advanced Micro Devices, Inc. (Santa Clara, California)
INVENTOR(S)	Khaled Hamidouche (Austin, Texas); Michael Wayne LeBeane (Austin, Texas); Walter B. Benton (Austin, Texas)
ABSTRACT	Systems, apparatuses, and methods for performing network packet templating for graphics processing unit (GPU)-initiated communication are disclosed. A central processing unit (CPU) creates a network packet according to a template and populates a first subset of fields of the network packet with static data. Next, the CPU stores the network packet in a memory. A GPU initiates execution of a kernel and detects a network communication request within the kernel and prior to the kernel completing execution. Responsive to this determination, the GPU populates a second subset of fields of the network packet with runtime data. Then, the GPU generates a notification that the network packet is ready to be processed. A network interface controller (NIC) processes the network packet using data retrieved from the first subset of fields and from the second subset of fields responsive to detecting the notification.
FILED	Thursday, June 28, 2018
APPL NO	16/022498
ART UNIT	2194 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 9/546 (20130101) Original (OR) Class G06F 12/023 (20130101) G06F 2212/1016 (20130101)
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10740775 — Transactive control and coordination framework and associated toolkit functions

US 10740775	Hammerstrom et al.
FUNDED BY	Department of Energy (DOE) Office of Electricity (DOE-OE)
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	Donald J. Hammerstrom (West Richland, Washington); Ron Melton (Richland, Washington); Trishan Esram (Richland, Washington); John E. Hathaway (Richland, Washington)
ABSTRACT	Disclosed herein are representative embodiments of methods, apparatus, and systems for facilitating operation and control of a resource distribution system (such as a power grid). For example, embodiments of the disclosed technology can be used to improve the resiliency of a power grid and to allow for improved consumption of renewable resources. Further, certain implementations facilitate a degree of decentralized operations not available elsewhere.
FILED	Monday, December 16, 2013
APPL NO	14/108078
ART UNIT	2116 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0206 (20130101) Original (OR) Class G06Q 50/06 (20130101) Systems Integrating Technologies Related to Power Network Operation, Communication or Information Technologies for Improving the Electrical Power Generation, Transmission, Distribution, Management or Usage, i.e Smart Grids Y04S 50/14 (20130101)
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10741038 — System and method of detecting and analyzing a threat in a confined environment

US 10741038	Skorpik et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S)	Battelle Memorial Institute (Richland, Washington)
INVENTOR(S)	James R. Skorpik (Kennewick, Washington); Michael S. Hughes (Richland, Washington); Eric G. Gonzalez (Richland, Washington)
ABSTRACT	A system and method of detecting and analyzing a threat in a confined environment is disclosed. An audio board detects and analyzes audio signals which are then transmitted and analyzed to determine the location of a gunshot in a confined location and the type of firearm being shot.
FILED	Wednesday, April 03, 2019
APPL NO	16/374635
ART UNIT	2688 — Dynamic Storage Systems; Mechanical parts of Disk Drives
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/18 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 7/064 (20130101) G08B 13/1672 (20130101) G08B 21/02 (20130101) Original (OR) Class G08B 25/009 (20130101) G08B 29/185 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/51 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 3/005 (20130101) H04R 2499/11 (20130101)
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10741297 — 3-dimensional x-ray imager

US 10741297	Kozioziemski et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Bernard J. Kozioziemski (Livermore, California); Nobuhiko Izumi (Oakland, California); Julia K. Vogel (Pleasanton, California); Louisa A. P. Pickworth (Pleasanton, California)
ABSTRACT	The invention utilizes one exposure without moving parts to provide multiple x-ray views of an object. It relies on a 3D detector, which can be a stack of film plates, and a specified focusing x-ray optic. The x-ray optic, discussed below, allows collection of x-rays from a localized volume, just like an ordinary optical lens, and the stacked film plate, or other 3D detector design, allows collection of the multiple focal plane information from one line of sight.
FILED	Tuesday, October 30, 2018
APPL NO	16/174625
ART UNIT	2884 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/022 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/085 (20180201) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/062 (20130101) Original (OR) Class G21K 7/00 (20130101) G21K 2201/062 (20130101)
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10741337 — Mesoporous nanocrystalline film architecture for capacitive storage devices

US 10741337	Dunn et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Bruce S. Dunn (Los Angeles, California); Sarah H. Tolbert (Los Angeles, California); John Wang (Glendora, California); Torsten Brezesinski (Karlsruhe, Germany); George Gruner (Los Angeles, California)
ABSTRACT	A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling stability. Charge storage devices with electrodes using the construct can use three different charge storage mechanisms immersed in an electrolyte: (1) cations can be stored in a thin double layer at the electrode/electrolyte interface (non-faradaic mechanism); (2) cations can interact with the bulk of an electroactive material which then undergoes a redox reaction or phase change, as in conventional batteries (faradaic mechanism); or (3) cations can electrochemically adsorb onto the surface of a material through charge transfer processes (faradaic mechanism).
FILED	Tuesday, March 13, 2018
APPL NO	15/919295
ART UNIT	2848 — Electrical Circuits and Systems
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 99/00 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/26 (20130101) H01G 11/28 (20130101) H01G 11/36 (20130101) H01G 11/46 (20130101) H01G 11/48 (20130101) H01G 11/84 (20130101) Original (OR) Class H01G 11/86 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 999/99 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/948 (20130101)
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10741399 — Femtosecond laser-induced formation of submicrometer spikes on a semiconductor substrate

US 10741399	Mazur et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S)	Eric Mazur (Concord, Massachusetts); Mengyan Shen (Belmont, Massachusetts)
ABSTRACT	The present invention generally provides semiconductor substrates having submicron-sized surface features generated by irradiating the surface with ultra short laser pulses. In one aspect a method of processing a semiconductor substrate is disclosed that includes placing at least a portion of a surface of the substrate in contact with a fluid, and exposing that surface portion to one or more femtosecond pulses so as to modify the topography of that portion. The modification can include, e.g., generating a plurality of submicron-sized spikes in an upper layer of the surface.
FILED	Wednesday, February 14, 2018
APPL NO	15/896940
ART UNIT	2819 — Semiconductors/Memory
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/1224 (20151001) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0259 (20130101) H01L 21/268 (20130101) Original (OR) Class H01L 21/302 (20130101) H01L 21/2252 (20130101) H01L 21/02381 (20130101) H01L 21/02532 (20130101) H01L 21/02686 (20130101) H01L 21/67075 (20130101) H01L 29/30 (20130101) H01L 29/34 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 438/94 (20130101)
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10741708 — Vertically stacked photovoltaic and thermal solar cell

US 10741708	Curran et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	University of Houston (Houston, Texas)
ASSIGNEE(S)	UNIVERSITY OF HOUSTON (Houston, Texas)
INVENTOR(S)	Seamus Curran (Pearland, Texas); Sampath Dias (Houston, Texas); Kang-Shyang Liao (Houston, Texas); Soniya Devi Yambem (Houston, Texas); Amrita Haldar (Dublin, California); Nigel Alley (Houston, Texas)
ABSTRACT	According to some embodiments, the present invention provides a novel photovoltaic solar cell system from photovoltaic modules that are vertically arrayed in a stack format using thin film semiconductors selected from among organic and inorganic thin film semiconductors. The stack cells may be cells that are produced in a planar manner, then vertically oriented in an angular form, also termed herein tilted, to maximize the light capturing aspects. The use of a stack configuration system as described herein allows for the use of a variety of electrode materials, such as transparent materials or semitransparent metals. Light concentration can be achieved by using fresnel lens, parabolic mirrors or derivatives of such structures. The light capturing can be controlled by being reflected back and forth in the photovoltaic system until significant quantities of the resonant light is absorbed. Light that passes to the very end and can be reflected back through the device by beveling or capping the end of the device with a different refractive index material, or alternatively using a reflective surface. The contacting between stacked cells can be done in series or parallel. According to some embodiments, the present invention uses a concentrator architecture where the light is channeled into the cells that contain thermal fluid channels (using a transparent fluid such as water) to absorb and hence reduce the thermal energy generation.
FILED	Thursday, July 05, 2018
APPL NO	16/027623
ART UNIT	1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/302 (20130101) H01L 31/043 (20141201) H01L 31/055 (20130101) H01L 31/0322 (20130101) Original (OR) Class H01L 31/0521 (20130101) H01L 31/0543 (20141201) H01L 31/0749 (20130101) H01L 51/426 (20130101) H01L 51/4253 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/52 (20130101) Y02E 10/541 (20130101)
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10741839 — Surface treatment for lithium battery electrode materials

US 10741839	Croy et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S)	Jason Croy (Plainfield, Illinois); Arturo Gutierrez (Naperville, Illinois); Michael M. Thackeray (Naperville, Illinois); Meinan He (Willowbrook, Illinois)
ABSTRACT	Electrode materials for electrochemical cells and batteries and methods of producing such materials are disclosed herein. A method of preparing an active lithium metal oxide material suitable for use in an electrode for a lithium electrochemical cell comprises the steps of: (a) contacting the lithium metal oxide material with an aqueous acidic solution containing one or more metal cations; and (b) heating the so-contacted lithium metal oxide from step (a) to dryness at a temperature below 200° C. The metal cations in the aqueous acidic solution comprise one or more metal cations selected from the group consisting of an alkaline earth metal ion, a transition metal ion, and a main group metal ion.
FILED	Thursday, March 01, 2018
APPL NO	15/909691
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 45/1257 (20130101) C01G 53/50 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/22 (20130101) C01P 2002/32 (20130101) C01P 2002/85 (20130101) C01P 2004/82 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 2004/028 (20130101) H01M 2300/0025 (20130101)
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10741845 — Stable lithium fluoride-based cathodes for metal and metal-ion batteries

US 10741845	Yushin et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Sila Nanotechnologies Inc. (Alameda, California)
ASSIGNEE(S)	SILA NANOTECHNOLOGIES INC. (Alameda, California)
INVENTOR(S)	Gleb Yushin (Atlanta, Georgia); Eugene Berdichevsky (Oakland, California); Bogdan Zdyrko (Clemson, South Carolina); Alexander Jacobs (Oakland, California); Daniel Gordon (Oakland, California); Nicholas Ingle (Berkeley, California); Laura Gerber (Oakland, California)
ABSTRACT	A battery electrode composition is provided that comprises composite particles. Each composite particle may comprise, for example, active lithium fluoride/metal nanocomposite material optionally embedded into a nanoporous, electrically-conductive skeleton matrix material particle(s), where each of these composite particles is further encased in a Li-ion permeable, chemically and mechanically robust, protective outer shell that is impermeable to electrolyte solvent molecules. The active lithium fluoride/metal nanocomposite material is provided to store and release Li ions during battery operation.
FILED	Wednesday, July 13, 2016
APPL NO	15/209619
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/38 (20130101) H01M 4/362 (20130101) H01M 4/366 (20130101) H01M 4/388 (20130101) H01M 4/582 (20130101) H01M 4/625 (20130101) Original (OR) Class H01M 4/5835 (20130101) H01M 10/0525 (20130101)
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10741850 — Dual conductor surface modified SOFC cathode particles and methods of making same

US 10741850	Huang et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Kevin Huang (Columbia, South Carolina); Jeffrey F. Roeder (Bethel, Connecticut); Anthony F. Zeberoff (Bethel, Connecticut)
ASSIGNEE(S)	Sonata Scientific LLC (Bethel, Connecticut)
INVENTOR(S)	Kevin Huang (Columbia, South Carolina); Jeffrey F. Roeder (Bethel, Connecticut); Anthony F. Zeberoff (Bethel, Connecticut)
ABSTRACT	A novel method to produce ALD films disposed on powders is disclosed. Examples include the formation of a cobalt doped zirconia (CDZ), hafnia, and cobalt doped hafnia (CDH) films on lanthanum strontium cobalt iron oxide (LSCF) powder for solid oxide fuel cell cathodes. The coated powders are sintered into porous cathodes that have utility for preventing the migration of cations in the powder to the surface of the sintered cathode and/or other performance enhancing attributes.
FILED	Friday, December 09, 2016
APPL NO	15/374981
ART UNIT	1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8663 (20130101) H01M 4/8889 (20130101) Original (OR) Class H01M 2004/8689 (20130101) H01M 2008/1293 (20130101)
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10742894 — Optical array for high-quality imaging in harsh environments

US 10742894	Baba et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Justin S. Baba (Knoxville, Tennessee); Philip R. Bingham (Knoxville, Tennessee); David S. Bolme (Knoxville, Tennessee); Matthew R. Eicholtz (Lakeland, Florida); Regina Kay Ferrell (Knoxville, Tennessee); Christi R. Johnson (Kingston, Tennessee); Hector J. Santos-Villalobos (Knoxville, Tennessee)
ABSTRACT	Methods and apparatus are disclosed for producing high quality images in uncontrolled or impaired environments. In some examples of the disclosed technology, groups of cameras for high dynamic range (HDR), polarization diversity, and optional other diversity modes are arranged to concurrently image a common scene. For example, in a vehicle checkpoint application, HDR provides discernment of dark objects inside a vehicle, while polarization diversity aids in rejecting glare. Spectral diversity, infrared imaging, and active illumination can be applied for better imaging through a windshield. Preprocessed single-camera images are registered and fused. Faces or other features of interest can be detected in the fused image and identified in a library. Impairments can include weather, insufficient or interfering lighting, shadows, reflections, window glass, occlusions, or moving objects.
FILED	Wednesday, August 08, 2018
APPL NO	16/058948
ART UNIT	2632 — Digital Communications
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/209 (20130101) G06K 9/00255 (20130101) G06K 9/00785 (20130101) G06K 9/00832 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/007 (20130101) G06T 5/008 (20130101) G06T 5/50 (20130101) G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) G06T 2207/10028 (20130101) G06T 2207/10048 (20130101) G06T 2207/20052 (20130101) G06T 2207/20076 (20130101) G06T 2207/20084 (20130101) G06T 2207/20208 (20130101) G06T 2207/20221 (20130101) G06T 2207/30201 (20130101) G06T 2207/30268 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) H04N 5/247 (20130101) H04N 5/2256 (20130101) H04N 5/2258 (20130101) H04N 5/2355 (20130101) Original (OR) Class H04N 13/327 (20180501)
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10743419 — Circuit board interconnect decals

US 10743419	Hatch et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Kansas City National Security Campus (KCNSC) NNSA Critical Mission Site Operated by Honeywell Federal Manufacturing and Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S)	HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
ASSIGNEE(S)	Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S)	Stephen McGarry Hatch (Blue Springs, Missouri); Jonathan Douglas Hatch (Cleveland, Missouri)
ABSTRACT	A circuit component decal comprising a transparent sheet and an opaque circuit pattern. The transparent sheet includes opposing top and bottom surfaces and a number of edges. The opaque circuit pattern includes an electronic component footprint and a number of circuit lead paths. The electronic component footprint includes a number of contact points representing the location of leads of the electronic component. The circuit lead paths extend from the contact points to the edges of the transparent sheet. The opaque circuit pattern corresponds to only a section of a complete circuit pattern and is configured to block energy from reaching a first portion of the intermediate substrate when the transparent sheet is positioned on the intermediate substrate so as to form the section of the complete circuit pattern.
FILED	Friday, December 27, 2019
APPL NO	16/728221
ART UNIT	2847 — Electrical Circuits and Systems
CURRENT CPC	Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/29 (20180101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 3/048 (20130101) Original (OR) Class H05K 2203/0121 (20130101) H05K 2203/0186 (20130101) H05K 2203/0557 (20130101)
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National Aeronautics and Space Administration (NASA)

10738373 — Apparatus and method for using shape memory alloys to form shapes

US 10738373	Benafan et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of Americas as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as Represented by the Administrator of National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Othmane Benafan (Middleburg Heights, Ohio); Eunice E. Arvizu (Middleburg Heights, Ohio)
ABSTRACT	An apparatus and method for creating shapes (e.g., letters, numbers, characters, symbols, or a combination thereof) using shape memory alloy (SMAs) component. The SMA components shaped into formed shapes that can then be distorted to obscure the original formed shaped. The original formed shape can be restored upon exposure to a heat source, magnetic field, or upon load removal.
FILED	Tuesday, September 26, 2017
APPL NO	15/715687
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/006 (20130101) Original (OR) Class C22F 1/10 (20130101)
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10738627 — Geared low fan pressure ratio fan exit guide vane stagger angle

US 10738627	Gallagher et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Edward J. Gallagher (West Hartford, Connecticut); Glen E. Potter (Vernon, Connecticut); Barry M. Ford (Middletown, Connecticut)
ABSTRACT	A fan exit guide vane assembly for a gas turbine engine includes a plurality of guide vanes having a pressure side and a suction side extending between a leading edge and a trailing edge. The vanes further include a span extending between a root and tip with a stagger angle defined as an angle between a longitudinal axis parallel to an engine axis of rotation and a line connecting the leading edge and the trailing edge that is less than about 15°.
FILED	Monday, January 15, 2018
APPL NO	15/871248
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 1/023 (20130101) F01D 5/021 (20130101) F01D 5/141 (20130101) F01D 9/04 (20130101) Original (OR) Class F01D 25/24 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/107 (20130101) Jet-propulsion Plants F02K 3/06 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2220/36 (20130101) F05D 2230/60 (20130101) F05D 2240/12 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49323 (20150115)
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10738888 — Single piece, redundant, bi-directional, seal damage prevention pressure seal

US 10738888	Smallwood
FUNDED BY	National Aeronautics and Space Administration (NASA) John F. Kennedy Space Center (KSC)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Drew L. Smallwood (Chicago, Illinois)
ABSTRACT	An example seal for use with a laminated window is described. The seal includes a first end formed from a first material and a second end formed from the first material, with the first material being compressible when a pressure force is applied to the first material. The seal also includes a connection portion positioned between the first end and the second end. At least some of the connection portion is formed from a second material having a greater indentation hardness than an indentation hardness of the first material. An example method for installing a seal is also described.
FILED	Wednesday, December 12, 2018
APPL NO	16/218021
ART UNIT	3633 — Static Structures, Supports and Furniture
CURRENT CPC	Windows, Windscreens, Non-fixed Roofs, Doors, or Similar Devices for Vehicles; Removable External Protective Coverings Specially Adapted for Vehicles B60J 10/16 (20160201) B60J 10/70 (20160201) Aeroplanes; Helicopters B64C 1/1492 (20130101) Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 5/12 (20130101) E06B 7/22 (20130101) E06B 2003/6258 (20130101) E06B 2003/6276 (20130101) Pistons; Cylinders; Sealings F16J 15/022 (20130101) Original (OR) Class
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10739522 — Optical energy transfer and conversion system for remotely operated vehicle having axially configured fiber spooler mounted thereon

US 10739522	Stone et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Stone Aerospace, Inc. (Del Valle, Texas)
ASSIGNEE(S)	Stone Aerospace, Inc. (Del Valle, Texas)
INVENTOR(S)	William C. Stone (Del Valle, Texas); Bartholomew P. Hogan (Rockville, Maryland)
ABSTRACT	An optical energy transfer and conversion system comprising a fiber spooler and an electrical power extraction subsystem connected to the spooler with an optical waveguide. Optical energy is generated at and transferred from a base station through fiber wrapped around the spooler, and ultimately to the power extraction system at a remote mobility platform for conversion to another form of energy. The fiber spooler may reside on the remote mobility platform which may be a vehicle, or apparatus that is either self-propelled or is carried by a secondary mobility platform either on land, under the sea, in the air or in space.
FILED	Monday, January 15, 2018
APPL NO	15/871671
ART UNIT	2883 — Optics
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/00 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 41/0085 (20130101) E21B 47/135 (20200501) Optical Elements, Systems, or Apparatus G02B 6/3604 (20130101) Original (OR) Class G02B 6/4268 (20130101) G02B 6/4296 (20130101) G02B 6/4415 (20130101) G02B 6/4436 (20130101) G02B 6/4458 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/30 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/025 (20130101) H02J 50/30 (20160201) H02J 50/90 (20160201)
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10739523 — Optical energy transfer and conversion system for unmanned aerial vehicle having axially configured fiber spooler mounted thereon

US 10739523	Stone et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Stone Aerospace, Inc. (Del Valle, Texas)
ASSIGNEE(S)	Stone Aerospace, Inc. (Del Valle, Texas)
INVENTOR(S)	William C. Stone (Del Valle, Texas); Bartholomew P. Hogan (Rockville, Maryland)
ABSTRACT	An optical energy transfer and conversion system comprising a fiber spooler and an electrical power extraction subsystem connected to the spooler with an optical waveguide. Optical energy is generated at and transferred from a base station through fiber wrapped around the spooler, and ultimately to the power extraction system at a remote mobility platform for conversion to another form of energy. The fiber spooler may reside on the remote mobility platform which may be a vehicle, or apparatus that is either self-propelled or is carried by a secondary mobility platform either on land, under the sea, in the air or in space.
FILED	Monday, January 15, 2018
APPL NO	15/871693
ART UNIT	2883 — Optics
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/00 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 41/0085 (20130101) E21B 47/135 (20200501) Optical Elements, Systems, or Apparatus G02B 6/3604 (20130101) Original (OR) Class G02B 6/4268 (20130101) G02B 6/4296 (20130101) G02B 6/4415 (20130101) G02B 6/4436 (20130101) G02B 6/4458 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/30 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/025 (20130101) H02J 50/30 (20160201) H02J 50/90 (20160201)
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10739524 — Optical energy transfer and conversion system for planetary rover having axially configured fiber spooler mounted thereon

US 10739524	Stone et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Stone Aerospace, Inc. (Del Valle, Texas)
ASSIGNEE(S)	Stone Aerospace, Inc. (Del Valle, Texas)
INVENTOR(S)	William C. Stone (Del Valle, Texas); Bartholomew P. Hogan (Rockville, Maryland)
ABSTRACT	An optical energy transfer and conversion system comprising a fiber spooler and an electrical power extraction subsystem connected to the spooler with an optical waveguide. Optical energy is generated at and transferred from a base station through fiber wrapped around the spooler, and ultimately to the power extraction system at a remote mobility platform for conversion to another form of energy. The fiber spooler may reside on the remote mobility platform which may be a vehicle, or apparatus that is either self-propelled or is carried by a secondary mobility platform either on land, under the sea, in the air or in space.
FILED	Monday, January 15, 2018
APPL NO	15/871708
ART UNIT	2883 — Optics
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/00 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 41/0085 (20130101) E21B 47/135 (20200501) Optical Elements, Systems, or Apparatus G02B 6/3604 (20130101) Original (OR) Class G02B 6/4268 (20130101) G02B 6/4296 (20130101) G02B 6/4415 (20130101) G02B 6/4436 (20130101) G02B 6/4458 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/30 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/025 (20130101) H02J 50/30 (20160201) H02J 50/90 (20160201)
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10739525 — Optical energy transfer and conversion system for autonomous underwater vehicle having drum configured fiber spooler mounted thereon

US 10739525	Stone et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Stone Aerospace, Inc. (Del Valle, Texas)
ASSIGNEE(S)	Stone Aerospace, Inc. (Del Valle, Texas)
INVENTOR(S)	William C. Stone (Del Valle, Texas); Bartholomew P. Hogan (Rockville, Maryland)
ABSTRACT	An optical energy transfer and conversion system comprising a fiber spooler and an electrical power extraction subsystem connected to the spooler with an optical waveguide. Optical energy is generated at and transferred from a base station through fiber wrapped around the spooler, and ultimately to the power extraction system at a remote mobility platform for conversion to another form of energy. The fiber spooler may reside on the remote mobility platform which may be a vehicle, or apparatus that is either self-propelled or is carried by a secondary mobility platform either on land, under the sea, in the air or in space.
FILED	Monday, January 15, 2018
APPL NO	15/871727
ART UNIT	2883 — Optics
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/00 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 41/0085 (20130101) E21B 47/135 (20200501) Optical Elements, Systems, or Apparatus G02B 6/3604 (20130101) Original (OR) Class G02B 6/4268 (20130101) G02B 6/4296 (20130101) G02B 6/4415 (20130101) G02B 6/4436 (20130101) G02B 6/4458 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/30 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/025 (20130101) H02J 50/30 (20160201) H02J 50/90 (20160201)
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10742115 — Self-regulating current circuit apparatus and method

US 10742115	Hesh et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Scott V. Hesh (Greenbackville, Virginia); Michael J. Mahon (Severna Park, Maryland)
ABSTRACT	The present invention relates to an apparatus including a self-regulating current source, which utilizes a switching regulator to provide high efficiency power conversion and a high-side current monitor, but instead of driving the feedback input with a voltage divider to set the output voltage, the self-regulating current source utilizes a high-side current sense resistor with an operational amplifier optimized for current sensing, to drive the feedback input to the switching regulator, thereby creating a self-regulating constant current source. By adjusting the gain of the operational amplifier, the user can directly set the optimized current needed for using the apparatus in a variety of deployment devices, including satellite and pyrotechnic applications.
FILED	Thursday, March 14, 2019
APPL NO	16/352959
ART UNIT	2839 — Electrical Circuits and Systems
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/645 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 3/10 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/44 (20130101) H02M 3/04 (20130101) Original (OR) Class H02M 2001/0009 (20130101)
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Department of Agriculture (USDA)

10737234 — Microchannel reactors and fabrication processes

US 10737234	Luzenski et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Robert J. Luzenski (Marysville, Ohio); Jeffery D. Slane (Galloway, Ohio); Thomas D. Yuschak (Lewis Center, Ohio); Paul W. Neagle (Westerville, Ohio); Michael Marchiando (London, Ohio)
ASSIGNEE(S)	VELOCYS, INC. (Plain City, Ohio)
INVENTOR(S)	Robert J. Luzenski (Marysville, Ohio); Jeffery D. Slane (Galloway, Ohio); Thomas D. Yuschak (Lewis Center, Ohio); Paul W. Neagle (Westerville, Ohio); Michael Marchiando (London, Ohio)
ABSTRACT	A method of loading material within a microchannel device, the method comprising: (a) loading particulates into a plurality of microchannels; and, (b) ultrasonically packing the particulates into the plurality of microchannels using a portable, compact ultrasonic densification unit.
FILED	Monday, October 01, 2018
APPL NO	16/147898
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/0015 (20130101) B01J 8/16 (20130101) B01J 8/18 (20130101) B01J 8/1881 (20130101) B01J 19/0093 (20130101) Original (OR) Class B01J 2219/00783 (20130101) B01J 2219/00801 (20130101) B01J 2219/00806 (20130101) B01J 2219/00817 (20130101) B01J 2219/00835 (20130101) B01J 2219/00844 (20130101) B01J 2219/00873 (20130101) B01J 2219/00932 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 2200/0647 (20130101) B01L 2400/0436 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 67/00 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 2/32 (20130101) C10G 2/34 (20130101)
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10737958 — Processes and treatment systems for treating high phosphorous containing fluids

US 10737958	Church et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Clinton Church (Julian, Pennsylvania); Ray B. Bryant (Spring Mills, Pennsylvania); Peter J. Kleinman (Warriors Mark, Pennsylvania); Alex Hristov (State College, Pennsylvania)
ABSTRACT	Disclosed herein are processes for treating high-P fluid involving (1) providing a high-P containing stream; (2) chemically treating the high-P stream such that a majority of dissolved P in the stream is transformed into a solid form via sorption of P onto particles placed or precipitated within the stream; and (3) removing the solid form containing P from the chemically treated fine solids stream, such that > about 90% of the total P is removed from the high-P fluid. Also disclosed are systems for treating a high-P stream, the systems involving (1) a chemical treatment station operable to chemically treat and transform equal to or greater than about 90% of dissolved P in a high-P stream into a solid form; and (2) a liquid-solid separator station operable to remove the solid form containing P from the chemically treated high-P stream.
FILED	Monday, September 11, 2017
APPL NO	15/700724
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/02 (20130101) B01J 20/08 (20130101) B01J 20/041 (20130101) B01J 20/045 (20130101) B01J 20/046 (20130101) B01J 20/0225 (20130101) B01J 20/0229 (20130101) B01J 20/0248 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) C02F 1/52 (20130101) C02F 1/56 (20130101) C02F 1/281 (20130101) C02F 1/5236 (20130101) C02F 1/5245 (20130101) Original (OR) Class C02F 11/14 (20130101) C02F 11/121 (20130101) C02F 11/125 (20130101) C02F 11/127 (20130101) C02F 2101/105 (20130101) C02F 2103/20 (20130101) C02F 2201/008 (20130101)
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10738088 — Non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) and methods of using

US 10738088	Vu et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	NUtech Ventures (Lincoln, Nebraska); The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	NUtech Ventures (Lincoln, Nebraska); The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Hiep Lai Xuan Vu (Lincoln, Nebraska); Fernando Osorio (Lincoln, Nebraska); William W. Laegreid (Laramie, Wyoming); Asit K. Pattnaik (Lincoln, Nebraska); Fangrui Ma (Lincoln, Nebraska)
ABSTRACT	A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally occurring PRRSV also are provided.
FILED	Friday, August 03, 2018
APPL NO	16/054327
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/552 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/10021 (20130101) C12N 2770/10022 (20130101) C12N 2770/10034 (20130101)
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10738321 — Methods and compositions for preventing or reducing infections of crop plants by bacterial and fungal pathogens

US 10738321	Gabriel et al.
FUNDED BY	Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS)
APPLICANT(S)	Integrated Plant Genetics, Inc. (Gainesville, Florida); University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	INTEGRATED PLANT GENETICS, INC. (Gainesville, Florida); UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida)
INVENTOR(S)	Dean W. Gabriel (Gainesville, Florida); Shujian Zhang (Los Alamos, New Mexico)
ABSTRACT	The present invention teaches methods and compositions useful for treating, preventing, or curing pathogen infections of living plants. In particular, the present invention teaches methods of enhancing plant response to pathogen-associated molecular patterns. The methods and compositions described herein are effective at treating biotrophic pathogens, including Liberibacters.
FILED	Thursday, May 25, 2017
APPL NO	15/605700
ART UNIT	1662 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/8218 (20130101) C12N 15/8281 (20130101) C12N 15/8282 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/531 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6895 (20130101) C12Q 2600/13 (20130101)
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Department of Commerce (DOC)

10737390 — Collaborative robot motion and force-torque gauges

US 10737390	Dagalakis et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)	GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Gaithersburg, Maryland)
INVENTOR(S)	Nicholas G. Dagalakis (Potomac, Maryland); Yong Sik Kim (Boyds, Maryland)
ABSTRACT	A collaborative robot motion gauge determines a motion of a collaborative robot and includes: a bar; a dextral metrology member disposed on the bar; a dextral motion coupler moveably disposed on the bar; a dextral displacement sensor disposed on the dextral metrology member in communication with the dextral motion coupler; a dextral arm coupler disposed on the dextral motion coupler and that: couples to a dextral arm of the collaborative robot to the dextral motion coupler; communicates motion of the dextral arm to the dextral displacement sensor; and moves the dextral motion coupler in response to motion of the dextral arm; a sinistral metrology member disposed on the bar at a sinistral position; a sinistral motion coupler; a sinistral displacement sensor in communication with the sinistral motion coupler; and a sinistral arm coupler that couples a sinistral arm to the sinistral motion coupler.
FILED	Tuesday, February 20, 2018
APPL NO	15/899597
ART UNIT	3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Manipulators; Chambers Provided With Manipulation Devices B25J 9/1641 (20130101) B25J 9/1692 (20130101) Original (OR) Class B25J 9/1694 (20130101) B25J 17/0275 (20130101) B25J 18/00 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/09 (20130101) Y10S 901/29 (20130101) Y10S 901/46 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10740465 — Detection of print-based spoofing attacks

US 10740465	Komogortsev
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Texas State University (San Marcos, Texas)
ASSIGNEE(S)	Texas State University San Marcos (San Marcos, Texas)
INVENTOR(S)	Oleg V. Komogortsev (Austin, Texas)
ABSTRACT	A method of assessing the possibility of an iris print-attack includes measurement of the eye movement of a person. One or more values (e.g., a feature vector) are determined based on the measured eye movements. Based on the determined values, an assessment is made of whether or not the person is engaging in an iris print-attack.
FILED	Monday, December 07, 2015
APPL NO	15/533191
ART UNIT	2431 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/32 (20130101) G06F 21/566 (20130101) Original (OR) Class G06F 2221/031 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0061 (20130101) G06K 9/00906 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10741742 — Enhanced superconducting transition temperature in electroplated rhenium

US 10741742	David et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado); GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE, NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY (Gaithersburg, Maryland)
INVENTOR(S)	Donald David (Broomfield, Colorado); David Pappas (Boulder, Colorado); Xian Wu (Westminster, Colorado)
ABSTRACT	This disclosure describes systems, methods, and apparatus for multilayer superconducting structures comprising electroplated Rhenium, where the Rhenium operates in a superconducting regime at or above 4.2 K, or above 1.8 K where specific temperatures and times of annealing have occurred. The structure can include at least a first conductive layer applied to a substrate, where the Rhenium layer is electroplated to the first layer. A third layer formed from the same or a different conductor as the first layer can be formed atop the Rhenium layer.
FILED	Thursday, February 28, 2019
APPL NO	16/289599
ART UNIT	2847 — Electrical Circuits and Systems
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/043 (20130101) B32B 2255/06 (20130101) B32B 2255/205 (20130101) B32B 2307/202 (20130101) B32B 2457/08 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 12/02 (20130101) H01B 12/06 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/12 (20130101) Original (OR) Class H01L 39/14 (20130101) H01L 39/24 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10741793 — Light emitting device including blue emitting quantum dots and method

US 10741793	Niu et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Advanced Technology Program (NIST-ATP) Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	SAMSUNG RESEARCH AMERICA, INC. (Mountain View, California)
ASSIGNEE(S)	SAMSUNG RESEARCH AMERICA, INC. (Mountain View, California)
INVENTOR(S)	Yuhua Niu (Waltham, Massachusetts); Peter T. Kazlas (Sudbury, Massachusetts)
ABSTRACT	A method for preparing a light emitting device comprising: disposing an electron-injection layer comprising a metal oxide on a cathode, disposing a first layer adjacent the electron-injection layer, the first layer comprising a small molecule material with a bandgap of at least about 3 eV capable of blocking holes, forming an emissive layer comprising quantum dots capable of emitting blue light upon excitation at a surface of the first layer opposite the electron-injection layer; disposing a second layer comprising a material capable of transporting holes and blocking electrons with a bandgap of at least about 3 eV adjacent a surface of the emissive layer opposite the first layer, and disposing an anode over the second layer. A light-emitting device is also disclosed.
FILED	Thursday, July 03, 2014
APPL NO	14/323900
ART UNIT	2817 — Semiconductors/Memory
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/025 (20130101) C09K 11/565 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0026 (20130101) H01L 51/56 (20130101) H01L 51/502 (20130101) H01L 51/5088 (20130101) H01L 51/5092 (20130101) H01L 51/5096 (20130101) H01L 51/5262 (20130101) Original (OR) Class H01L 2251/55 (20130101) H01L 2251/556 (20130101) H01L 2251/558 (20130101) H01L 2251/5353 (20130101) H01L 2251/5369 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 33/10 (20130101) H05B 33/12 (20130101)
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Small Business Administration (SBA)

10738298 — Apparatuses, methods and systems for automated processing of nucleic acids and electrophoretic sample preparation

US 10738298	Abrams et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	SAGE SCIENCE, INC. (Beverly, Massachusetts)
ASSIGNEE(S)	SAGE SCIENCE, INC. (Beverly, Massachusetts)
INVENTOR(S)	Ezra S. Abrams (Newton, Massachusetts); Danny Yun (S. Hamilton, Massachusetts); Todd J. Barbera (Marblehead, Massachusetts); Douglas Grosvenor Sabin (Marblehead, Massachusetts); T. Christian Boles (Bedford, Massachusetts)
ABSTRACT	Methods, systems and apparatus for automated extraction, purification, and processing of nucleic acids from biological samples are presented. In some embodiments, hydrogel supports are used to immobilize particulate biological input samples and extract nucleic acids during operations. The use of hydrogel facilitates automated sample processing on robotic liquid handling systems. Devices, methods, and systems are also provided for electrophoretic sample preparation.
FILED	Thursday, November 15, 2018
APPL NO	16/192520
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 47/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/101 (20130101) Original (OR) Class C12N 15/1017 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44747 (20130101) G01N 27/44756 (20130101) G01N 27/44773 (20130101) G01N 27/44782 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10740371 — Systems and methods for intelligently configuring and deploying a machine learning-based dialogue system

US 10740371	Mars et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Clinc, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)	Clinc, Inc. (Ann Arbor, Michigan)
INVENTOR(S)	Jason Mars (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan); Parker Hill (Ann Arbor, Michigan); Yiping Kang (Ann Arbor, Michigan); Yunqi Zhang (Ann Arbor, Michigan)
ABSTRACT	A system and method for intelligently configuring a machine learning-based dialogue system includes a conversational deficiency assessment of a target dialog system, wherein implementing the conversational deficiency assessment includes: (i) identifying distinct corpora of mishandled utterances based on an assessment of the distinct corpora of dialogue data; (ii) identifying candidate corpus of mishandled utterances from the distinct corpora of mishandled utterances as suitable candidates for building new dialogue competencies for the target dialogue system if candidate metrics of the candidate corpus of mishandled utterances satisfy a candidate threshold; building the new dialogue competencies for the target dialogue system for each of the candidate corpus of mishandled utterances having candidate metrics that satisfy the candidate threshold; and configuring a dialogue system control structure for the target dialogue system based on the new dialogue competencies, wherein the dialogue system control structure governs an operation of an automated dialogue agent.
FILED	Wednesday, October 30, 2019
APPL NO	16/668559
ART UNIT	2659 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 16/3329 (20190101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6215 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101)
VIEW PATENT	@ USPTO: Full Text PDF

10740965 — Mapping complex building models

US 10740965	Young et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) U.S. Army Contracting Command (ACC) Redstone Arsenal (REDSTONE) Small Business Administration (SBA) Small Business Innovation Research (SBIR) Department of Transportation (USDOT) Federal Highway Administration (FHWA) National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S)	TRX Systems, Inc. (Greenbelt, Maryland)
ASSIGNEE(S)	TRX SYSTEMS, INC. (Greenbelt, Maryland)
INVENTOR(S)	Travis Young (Rockville, Maryland); Daniel Hakim (Silver Spring, Maryland); Daniel Franchy (Catonsville, Maryland); Jared Napora (Severn, Maryland); John Karvounis (Bowie, Maryland); Jonathan Fetter Degges (Washington, District of Columbia); Tim Wang (Germantown, Maryland); Benjamin Funk (Hanover, Maryland); Carole Teolis (Glendale, Maryland); Carol Politi (Bethesda, Maryland); Stuart Woodbury (Ellicott City, Maryland)
ABSTRACT	Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device.
FILED	Friday, May 31, 2019
APPL NO	16/428519
ART UNIT	2675 — Facsimile; Printer; Color; halftone; Scanner; Computer Graphic Processing; 3-D Animation; Display Color; Attributes; Object Processing; Hardware and Memory
CURRENT CPC	Electric Digital Data Processing G06F 30/13 (20200101) Image Data Processing or Generation, in General G06T 17/05 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10741171 — Kernel-based verbal phrase splitting devices and methods

US 10741171	Master et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	NANTMOBILE, LLC (Culver City, California)
ASSIGNEE(S)	NANTMOBILE, LLC (Culver City, California)
INVENTOR(S)	Demitrios L. Master (Cupertino, California); Farzad Ehsani (Sunnyvale, California)
ABSTRACT	A device capable of splitting user input into phrases is presented. The disclosed device leverages multiple phrase splitting models to generate one or more possible split locations. The possible split locations can be derived based on leveraging multiple phrase splitting models. Each model contributes its suggested split locations to the set of possible split locations according to an implementation of a phrase splitting kernel algorithm that weights each model's suggestions.
FILED	Monday, July 08, 2019
APPL NO	16/505485
ART UNIT	2659 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 40/284 (20200101) G06F 40/289 (20200101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/04 (20130101) Original (OR) Class G10L 15/22 (20130101) G10L 15/197 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Homeland Security (DHS)

10739337 — Extraction and detection of pathogens using carbohydrate-functionalized biosensors

US 10739337	Alocilja et al.
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	Evangelyn C. Alocilja (East Lansing, Michigan); Barbara Christine Cloutier (DeWitt, Michigan); Michael J. Anderson (Manassas, Virginia)
ASSIGNEE(S)	BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan)
INVENTOR(S)	Evangelyn C. Alocilja (East Lansing, Michigan); Barbara Christine Cloutier (DeWitt, Michigan); Michael J. Anderson (Manassas, Virginia)
ABSTRACT	The disclosure relates to the extraction and detection of pathogens using carbohydrate-functionalized biosensors. Immobilized carbohydrate moieties on the biosensor provide a means for non-specific binding of a plurality of target analytes. When a sample containing the target analyte is applied or otherwise transported to the biosensor detection surface, non-specific binding interactions between the carbohydrate moiety and the analyte immobilize/retain the analyte at the detection surface. The carbohydrate moiety is a stable binding pair member that allows on-sensor rinsing of a sample to enhance detection of an analyte in the sample. Specific analyte identification can be achieved with an analyte probe having a detection moiety and a binding pair member specific to the target analyte of interest.
FILED	Wednesday, August 29, 2012
APPL NO	13/598160
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) G01N 27/3275 (20130101) G01N 33/5434 (20130101) Original (OR) Class G01N 33/54393 (20130101) G01N 33/56911 (20130101)
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10740608 — Wide area intermittent video using non-orthorectified feature matching in long period aerial image capture with pixel-based georeferencing

US 10740608	Coulter et al.
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION (San Diego, California)
ASSIGNEE(S)	SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION (San Diego, California)
INVENTOR(S)	Lloyd Lawrence Arthur Coulter (Escondido, California); Christopher Lippitt (Albuquerque, New Mexico)
ABSTRACT	This application relates to techniques for obtaining wide area intermittent video (WAIV). Some embodiments disclosed herein include a method of obtaining WAIV. The method can include, for example, capturing images at a series of sensor stations having pre-determined locations along a flightline. The flightline can be repeated one or more times, where images are captured at the same sensor stations with each pass of the flightline. The captured images from the same sensor station may have replicated view geometry and may be co-registered and precisely aligned with pixel-level precision. The captured images from multiple sensor stations through time may also be displayed together based upon absolute or relative sensor station locations to create a temporal sequence of wide area intermittent video. The approach provides efficient methods for creating wide area video with reduced temporal imaging frame rates. Systems and devices for forming wide area intermittent video are also disclosed.
FILED	Monday, January 14, 2019
APPL NO	16/247552
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/127 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0063 (20130101) Original (OR) Class G06K 9/00711 (20130101) G06K 9/6202 (20130101) Image Data Processing or Generation, in General G06T 7/37 (20170101) G06T 7/60 (20130101) Traffic Control Systems G08G 5/0013 (20130101) G08G 5/0034 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10742404 — System and asynchronous protocol for verifiable secret sharing

US 10742404	Lampkins
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Joshua D. Lampkins (Gardena, California)
ABSTRACT	Described is a system for verifiable secret sharing amongst a plurality of servers, including a dealer server and one or more recipient servers. In operation, the dealer server encrypts a secret s using a polynomial and a hash tree with points on the polynomial as leaves. The dealer broadcasts to recipient servers hash tree data, root of the hash tree, and shares of the secret. Through an evaluation process the recipient servers are verified such that upon verification, the recipient servers reconstruct the secret s.
FILED	Thursday, March 28, 2019
APPL NO	16/367692
ART UNIT	2498 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 9/085 (20130101) Original (OR) Class H04L 9/3236 (20130101) H04L 67/12 (20130101)
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Department of Transportation (USDOT)

10740965 — Mapping complex building models

US 10740965	Young et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) U.S. Army Contracting Command (ACC) Redstone Arsenal (REDSTONE) Small Business Administration (SBA) Small Business Innovation Research (SBIR) Department of Transportation (USDOT) Federal Highway Administration (FHWA) National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S)	TRX Systems, Inc. (Greenbelt, Maryland)
ASSIGNEE(S)	TRX SYSTEMS, INC. (Greenbelt, Maryland)
INVENTOR(S)	Travis Young (Rockville, Maryland); Daniel Hakim (Silver Spring, Maryland); Daniel Franchy (Catonsville, Maryland); Jared Napora (Severn, Maryland); John Karvounis (Bowie, Maryland); Jonathan Fetter Degges (Washington, District of Columbia); Tim Wang (Germantown, Maryland); Benjamin Funk (Hanover, Maryland); Carole Teolis (Glendale, Maryland); Carol Politi (Bethesda, Maryland); Stuart Woodbury (Ellicott City, Maryland)
ABSTRACT	Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device.
FILED	Friday, May 31, 2019
APPL NO	16/428519
ART UNIT	2675 — Facsimile; Printer; Color; halftone; Scanner; Computer Graphic Processing; 3-D Animation; Display Color; Attributes; Object Processing; Hardware and Memory
CURRENT CPC	Electric Digital Data Processing G06F 30/13 (20200101) Image Data Processing or Generation, in General G06T 17/05 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10741066 — System and method for single-loop vehicle speed estimation using inductive loop signature data

US 10741066	Jeng
FUNDED BY	Department of Transportation (USDOT)
APPLICANT(S)	CLR Analytics Inc. (Irvine, California)
ASSIGNEE(S)	CLR Analytics Inc. (Irvine, California)
INVENTOR(S)	Shin-Ting Jeng (Corona, California)
ABSTRACT	A system and method are disclosed for using vehicle signature data from a single inductive loop sensor to estimate vehicle speed. Two regressors are calculated from the vehicle signature: the “inverse of the duration” and the “slew rate”. A point is found by normalizing the vehicle signature in amplitude and determining the earliest point in the normalized signature to cross a set threshold. The slew rate is the slope of the normalized vehicle signature at this point. Regression models are generated from empirical data for several vehicle categories. Using the regression model for the category of vehicle and the two regressors vehicle speed is estimated. The regression models have been demonstrated to be robust eliminating the need for site-specific calibration or estimation.
FILED	Thursday, December 28, 2017
APPL NO	15/857603
ART UNIT	2685 — Selective Communication
CURRENT CPC	Electric Digital Data Processing G06F 17/18 (20130101) Traffic Control Systems G08G 1/015 (20130101) G08G 1/042 (20130101) G08G 1/052 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10741856 — Fuel cell coolant flowfield configuration

US 10741856	O'Neill et al.
FUNDED BY	Department of Transportation (USDOT)
APPLICANT(S)	Jonathan Daniel O'Neill (Manchester, Connecticut); Sushant S. Bhadange (Vernon, Connecticut)
ASSIGNEE(S)	AUDI AG (Ingolstadt, Germany)
INVENTOR(S)	Jonathan Daniel O'Neill (Manchester, Connecticut); Sushant S. Bhadange (Vernon, Connecticut)
ABSTRACT	An exemplary method of cooling a fuel cell includes directing coolant through a coolant supply channel near at least one reactant flow channel. The coolant supply channel extends from a coolant inlet spaced from a reactant inlet to a coolant outlet. The coolant supply channel includes a first portion starting at the coolant inlet and a second portion near the reactant inlet. The first portion facilitates coolant flow from the coolant inlet directly toward the second portion. The second portion includes a plurality of channel sections that collectively facilitate coolant flow in a plurality of directions along the second portion near the reactant inlet. The coolant supply channel includes a third portion between the second portion and the coolant outlet.
FILED	Friday, July 20, 2012
APPL NO	14/414862
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0263 (20130101) H01M 8/0267 (20130101) H01M 8/04074 (20130101) Original (OR) Class H01M 8/04134 (20130101) H01M 2008/1095 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Veterans Affairs (DVA)

10738343 — Extracellular vesicle ribonucleic acid (RNA) cargo as a biomarker of hyperglycemia and type 1 diabetes

US 10738343	Mirmira et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Trustees of Indiana University (Indianapolis, Indiana); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana)
INVENTOR(S)	Raghavendra G. Mirmira (Zionsville, Indiana); Carmella Evans-Molina (Zionsville, Indiana); Emily K. Sims (Carmel, Indiana)
ABSTRACT	Methods and compositions are provided for detecting and/or determining a patient's risk of developing hyperglycemia or type 1 diabetes. The methods are directed to analyzing the miRNA content of extracellular vesicles recovered from said patient.
FILED	Thursday, January 17, 2019
APPL NO	16/250466
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/06 (20130101) Original (OR) Class C12Q 1/54 (20130101) C12Q 1/686 (20130101) C12Q 1/6883 (20130101) C12Q 2600/112 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/49 (20130101) G01N 2800/042 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Geospatial Intelligence Agency (NGA)

10741317 — Method of fabrication of composite monolithic structures

US 10741317	Chu
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Missile Defense Agency (MDA) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) National Security Engineering Center (NSEC) Federally Funded Research and Development Center (FFRDC) Operated by MITRE Corporation (MITRE) at Bedford, MA Under Secretary of Defense for Acquisition and Sustainment (USDA&S) National Geospatial Intelligence Agency (NGA)
APPLICANT(S)	The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S)	The MITRE Corporation (McLean, Virginia)
INVENTOR(S)	Alejandro Chu (Madison, Alabama)
ABSTRACT	Fabricating composite monolithic structures to achieve optimal electrical, thermal, and mechanical properties through the elimination of air is discussed herein. A method of fabricating a composite structure includes coating an insulating layer with an uncured binding material and performing a first curing process on the uncured binding material to form a first stage cured binding material on the insulating layer without introduction of air pockets in a conventional manufacturing atmospheric environment. The method further includes disposing the insulating layer on an array of conductive structures. The first stage cured binding material is positioned between the insulating layer and the array of conductive structures. The method further includes performing a second curing process on the first stage cured binding material to form a cured binding material, and forming cured regions between adjacent conductive structures of the array of conductive structures.
FILED	Friday, August 11, 2017
APPL NO	15/674790
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 5/06 (20130101) Original (OR) Class H01F 19/00 (20130101) H01F 27/288 (20130101) H01F 27/323 (20130101) H01F 41/122 (20130101) H01F 41/125 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Security Agency (NSA)

10740116 — Three-dimensional chip-based regular expression scanner

US 10740116	Van Lunteren et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Jan Van Lunteren (Gattikon, Switzerland); James Coghlan (Wappingers Falls, New York); Douglas J. Joseph (Leander, Texas)
ABSTRACT	A method for performing enhanced pattern scanning includes the steps of: providing a three-dimensional memory structure including multiple physical memory elements; compiling multiple programmable finite state machines, each of the programmable finite state machines representing at least one deterministic finite automation data structure, the data structure being distributed over at least a subset of the physical memory elements; configuring a subset of the programmable finite state machines to operate in parallel on a same input data stream, while each of the subset of programmable finite state machines processes a different pattern subset; and providing a local result processor, the local result processor transferring at least a part of a match state from the deterministic finite automation data structures to corresponding registers within the local result processor, the part of the match state being manipulated being based on instructions embedded within the deterministic finite automation data structures.
FILED	Tuesday, September 01, 2015
APPL NO	14/841825
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 9/4498 (20180201) Original (OR) Class G06F 30/34 (20200101) G06F 30/39 (20200101)
VIEW PATENT	@ USPTO: Full Text PDF

Office of the Director of National Intelligence (ODNI)

10741759 — Diffusive memristor and device for synaptic emulator

US 10741759	Yang et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Air Force Research Laboratory (AFRL) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Jianhua Yang (Hadley, Massachusetts); Qiangfei Xia (Amherst, Massachusetts); Mark McLean (Severna Park, Maryland); Qing Wu (Manilus, New York); Mark Barnell (Clay, New York)
ABSTRACT	A diffusive memristor device and an electronic device for emulating a biological synapse are disclosed. The diffusive memristor device includes a bottom electrode, a top electrode formed opposite the bottom electrode, and a dielectric layer disposed between the top electrode and the bottom electrode. The dielectric layer comprises silver doped silicon oxynitride (SiO_xN_y:Ag). In an alternate implementation, the dielectric layer comprises silver doped silicon oxide (Ag:SiO₂). An electronic synapse emulation device is also disclosed. The synapse emulation device includes a diffusive memristor device, a drift memristor device connected in series with the diffusive memristor device, a first voltage pulse generator connected to the diffusive memristor device, and a second voltage pulse generator connected to the drift memristor device. Application of a signal from one of the first voltage pulse generator or the second voltage pulse generator allows the synapse emulation device to exhibit long-term plasticity.
FILED	Wednesday, September 26, 2018
APPL NO	16/142310
ART UNIT	2896 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/085 (20130101) H01L 45/145 (20130101) H01L 45/146 (20130101) H01L 45/1233 (20130101) H01L 45/1253 (20130101) H01L 45/1266 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

United States Postal Service (USPS)

10737298 — System and method of unloading a container of items

US 10737298	Brown et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	John W. Brown (Manassas, Virginia); Edward F. Houston (Bristow, Virginia); Juan A. Roman (Fairfax, Virginia); Leung M. Shiu (Gaithersburg, Maryland); Riley H. Mayhall (Germantown, Maryland); William P. McConnell (Woodstock, Maryland); Matthew G. Good (Eldersburg, Maryland); Robert E. Hume (Woodstock, Maryland); Darin Dickey (Owings Mills, Maryland)
ABSTRACT	Embodiments of a system and method for unloading articles from a container of items for use in an automatic stack feeder are disclosed. The automatic stack feeder may comprise a belt, a moveable lower paddle, and a moveable upper paddle, wherein the lower paddle is configured to partially extend through a belt of the automatic stack feeder. The movement of the belt, the lower paddle, and the upper paddle are coordinated such that there is no need to interrupt the operation of the automatic stack feeder to unload the container.
FILED	Friday, August 25, 2017
APPL NO	15/687269
ART UNIT	3652 — Material and Article Handling
CURRENT CPC	Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 1/00 (20130101) B07C 1/04 (20130101) Original (OR) Class B07C 1/025 (20130101) Handling Thin or Filamentary Material, e.g Sheets, Webs, Cables B65H 1/025 (20130101) B65H 1/30 (20130101) B65H 1/263 (20130101) B65H 3/00 (20130101) B65H 2301/422542 (20130101) B65H 2301/422544 (20130101) B65H 2405/212 (20130101) B65H 2701/1916 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10738047 — Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof

US 10738047	Doroshow et al.
FUNDED BY
APPLICANT(S)	THE UNITED STATES OF AMERICA as represented by THE SECRETARY, DEPARTMENT OF HEALTH (Bethesda, Maryland); STARKS ASSOCIATES INC. (Buffalo, New York)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH (Bethesda, Maryland); STARKS ASSOCIATES INC. (Buffalo, New York)
INVENTOR(S)	James Halpern Doroshow (Bethesda, Maryland); Prabhakar Risbood (Germantown, Maryland); Jiamo Lu (Potomac, Maryland); Krishnendu Roy (Gaithersburg, Maryland); Charles T. Kane, Jr. (East Amherst, New York); Md Tafazzal Hossain (Amherst, New York)
ABSTRACT	Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.
FILED	Monday, October 15, 2018
APPL NO	16/160599
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) A61K 31/4745 (20130101) Acyclic or Carbocyclic Compounds C07C 43/225 (20130101) C07C 205/12 (20130101) C07C 233/15 (20130101) Heterocyclic Compounds C07D 333/28 (20130101) C07D 347/00 (20130101) C07D 409/12 (20130101) C07D 409/14 (20130101) C07D 471/04 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10739318 — Detection system including sensors and method of operating such

US 10739318	Huang et al.
FUNDED BY
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	BAKER HUGHES, A GE COMPANY, LLC (Houston, Texas)
INVENTOR(S)	Dayu Huang (Rexford, New York); Emad Andarawis Andarawis (Ballston Lake, New York); Edward James Nieters (Burnt Hills, New York); Cheng-Po Chen (Niskayuna, New York); Marco Guerriero (Niskayuna, New York)
ABSTRACT	A detection system includes a first sensor configured to send a first ultrasonic pulse toward an object in a blowout prevention system. The first ultrasonic pulse has a first parameter. The detection system also includes a second sensor spaced from the first sensor and configured to send a second ultrasonic pulse toward the object. The second ultrasonic pulse has a second parameter that is different from the first parameter of the first ultrasonic pulse. The first parameter and the second parameter are one of an amplitude, a frequency, a duration, an emission time, and an excitation code. The second sensor is further configured to receive the first ultrasonic pulse after the first ultrasonic pulse interacts with the object. The detection system is configured to determine that the first ultrasonic pulse received by the second sensor was sent by the first sensor. The detection system further includes a controller coupled to the second sensor and configured to determine a characteristic of the object based on the first ultrasonic pulse.
FILED	Wednesday, April 19, 2017
APPL NO	15/491083
ART UNIT	2861 — Printing/Measuring and Testing
CURRENT CPC	Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 33/06 (20130101) E21B 47/14 (20130101) E21B 47/091 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/11 (20130101) G01N 29/4418 (20130101) Original (OR) Class G01N 29/4472 (20130101) G01N 2291/015 (20130101) G01N 2291/044 (20130101) G01N 2291/106 (20130101) G01N 2291/2634 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10741149 — Assisted visual separation enhanced by graphical visualization

US 10741149	Bouda et al.
FUNDED BY
APPLICANT(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
ASSIGNEE(S)	HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
INVENTOR(S)	Tomas Bouda (Brno, Czech Republic); Zdenek Eichler (Olomouc, Czech Republic); Pavel Klang (Brno, Czech Republic)
ABSTRACT	Methods and apparatus are disclosed for providing visual assistance to a flight crew on an aircraft during flight. The method comprises generating a graphical user interface (GUI) element that displays a target aircraft symbol that represents a target aircraft and a horizontal range symbol that represents a pre-selected horizontal distance ahead of an ownship aircraft. The method further comprises positioning the target aircraft symbol at a variable position on the GUI element away from the horizontal range symbol, wherein the distance between the target aircraft symbol and the horizontal range symbol is proportional to an actual horizontal distance between the target aircraft position and the pre-selected horizontal distance ahead of the ownship aircraft; and causing the GUI element and the symbols to be displayed on a cockpit display.
FILED	Wednesday, May 23, 2018
APPL NO	15/987596
ART UNIT	2141 — Graphical User Interface and Document Processing
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 43/00 (20130101) Image Data Processing or Generation, in General G06T 11/60 (20130101) G06T 2200/24 (20130101) Traffic Control Systems G08G 5/0004 (20130101) Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 5/37 (20130101) Original (OR) Class G09G 2354/00 (20130101) G09G 2370/022 (20130101) G09G 2380/12 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10742208 — Circuit for driving switched transistor and filter, circulator and correlator including the same

US 10742208	Moyer et al.
FUNDED BY
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Harris P. Moyer (Los Angeles, California); Jongchan Kang (Moorpark, California); Hasan Sharifi (Agoura Hills, California); Ara K. Kurdoghlian (La Canada, California); James Lazar (Moorpark, California)
ABSTRACT	A circuit for driving a switched transistor comprises: a level shifter comprising at least one transistor, the level shifter configured to convert an input pulse to a pulse having a greater voltage swing than the input pulse and shift a voltage level of the converted pulse; and a pulse shaping filter coupled between the level shifter and the gate of the switched transistor, the pulse shaping filter tuned to cancel or reduce an impedance of the gate of the switched transistor. The switched transistor and/or the at least one transistor are a GaN High Electron Mobility Transistor (HEMT).
FILED	Friday, February 08, 2019
APPL NO	16/271725
ART UNIT	2648 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/2003 (20130101) H01L 29/7787 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/397 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 11/04 (20130101) Pulse Technique H03K 3/356017 (20130101) H03K 5/08 (20130101) H03K 17/687 (20130101) Original (OR) Class Transmission H04B 1/44 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/03834 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, August 11, 2020.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2020/fedinvent-patents-20200811.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

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