FedInvent™ Patents

Patent Details for Tuesday, August 18, 2020

This page was updated on Monday, March 27, 2023 at 06:09 AM GMT

Department of Health and Human Services (HHS)

10743773 — Imaging thermometry

US 10743773	Abi-Jaoudeh et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) U.S. Public Health Service (USPHS)
APPLICANT(S)	KONINKLIJKE PHILIPS N.V. (Eindhoven, Netherlands)
ASSIGNEE(S)	KONINKLIJKE PHILIPS N.V. (Eindhoven, Netherlands)
INVENTOR(S)	Nadine Abi-Jaoudeh (Washington, District of Columbia); Ming Li (Potomac, Maryland); Samuel Kadoury (Olney, Maryland); Ankur Kapoor (Cranbury, Maryland); Nicolaas Jan Noordhoek (Best, Netherlands); Alessandro Guido Radaelli (Oirschot, Netherlands); Bart Carelsen (Eindhoven, Netherlands); Bradford Johns Wood (Bethesda, Maryland)
ABSTRACT	A computing device includes a thermal map generator (142) that generates a thermal map for image data voxels or pixels representing a volume or region of interest of a subject based on thermometry image data, which includes voxels or pixels indicating a change in a temperature in the volume or region of interest, and a predetermined change in value to temperature lookup table (144) and a display (145) that visually presents the thermal map in connection with image data of the volume of interest. A method includes generating a thermal map for image data voxels or pixels representing a volume or region of interest of a subject based on thermometry image data, which includes voxels or pixels indicating a change in a temperature in the volume or region of interest, and a predetermined change in voxel or pixel value to temperature lookup table.
FILED	Friday, April 26, 2013
APPL NO	14/396064
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/015 (20130101) Original (OR) Class A61B 5/0035 (20130101) A61B 5/4839 (20130101) A61B 5/7278 (20130101) A61B 6/12 (20130101) A61B 6/032 (20130101) A61B 6/463 (20130101) A61B 6/466 (20130101) A61B 6/487 (20130101) A61B 6/4085 (20130101) A61B 6/4417 (20130101) A61B 6/4441 (20130101) A61B 6/5247 (20130101) A61B 6/5264 (20130101) A61B 18/20 (20130101) A61B 18/1477 (20130101) A61B 18/1815 (20130101) A61B 34/20 (20160201) A61B 2017/00084 (20130101) A61B 2018/00577 (20130101) A61B 2018/00791 (20130101) A61B 2018/00982 (20130101) A61B 2018/1425 (20130101) A61B 2018/1869 (20130101) A61B 2018/2005 (20130101) A61B 2018/205547 (20170501) A61B 2034/107 (20160201) A61B 2090/376 (20160201) A61B 2090/3762 (20160201) A61B 2090/3764 (20160201) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) A61N 7/022 (20130101) A61N 2007/025 (20130101) Image Data Processing or Generation, in General G06T 7/30 (20170101) G06T 2207/10081 (20130101) G06T 2207/30024 (20130101)
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10743785 — Hybrid one- and two-sided flow-encoding only (HOTFEO) for velocity-encoding phase contrast MRI

US 10743785	Hu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Peng Hu (Los Angeles, California); Da Wang (Los Angeles, California)
ABSTRACT	A phase-contrast MRI (PC-MRI) system and method employing a Hybrid One- and Two-sided Flow Encoding Only (HOTFEO) acquisition scheme for accurate blood flow and velocity measurements of three-directional-velocity-encoding PC-MRI.
FILED	Thursday, August 25, 2016
APPL NO	15/755041
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0263 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4822 (20130101) G01R 33/5635 (20130101) G01R 33/5673 (20130101) G01R 33/56316 (20130101) G01R 33/56518 (20130101)
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10743786 — Implantable micro-component electrodes

US 10743786	Kipke et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Daryl R. Kipke (Dexter, Michigan); Takashi Daniel Yoshida Kozai (Pittsburgh, Pennsylvania); Nick Langhals (Haslett, Michigan); Joerg Lahann (Ann Arbor, Michigan); Nicholas A. Kotov (Ypsilanti, Michigan); Xiaopei Deng (Ann Arbor, Michigan); Paras Patel (Ann Arbor, Michigan)
ABSTRACT	The present disclosure provides a method of fabricating an implantable micro-component electrode. The method includes disposing an electrically non-conductive material directly onto a surface of an electrically conductive carbon fiber core to generate an electrically non-conductive coating on the electrically conductive carbon fiber core, and removing a portion of the electrically non-conductive coating to expose a region of the electrically conductive carbon fiber core. The micro-component electrode has at least one dimension of less than or equal to about 10 μm.
FILED	Monday, February 19, 2018
APPL NO	15/899032
ART UNIT	1715 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/685 (20130101) A61B 5/04001 (20130101) Original (OR) Class A61B 2562/125 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/05 (20130101) A61N 1/0529 (20130101) A61N 1/0551 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101)
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10743791 — System and method for assessing tissue properties using magnetic resonance imaging

US 10743791	Reeder et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Scott B. Reeder (Madison, Wisconsin); Roberta M. Strigel (Madison, Wisconsin)
ABSTRACT	A system and method for assessing tissue properties of a subject within a region of interest (ROI) using a magnetic resonance imaging (MRI) system includes acquiring chemical-shift-encoded imaging data of the ROI. The method also includes determining, from imaging data a proton density water fraction (PDWF) map and quantifying, using the PDWF map, a property of tissue within the ROI. The method further includes generating, using the PDWF map, a report indicating the quantified property of the tissue. The tissue may include fibroglandular tissue (FGT).
FILED	Monday, December 28, 2015
APPL NO	14/981710
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class A61B 5/4312 (20130101) A61B 5/4872 (20130101) A61B 5/4875 (20130101) A61B 5/7282 (20130101) A61B 2576/02 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/485 (20130101) G01R 33/4828 (20130101) G01R 33/5608 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10088 (20130101) G06T 2207/30068 (20130101)
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10743848 — Biopsy device for coherent Raman imaging

US 10743848	Orringer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); INVENIO IMAGING, INC. (Santa Clara, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); INVENIO IMAGING, INC. (Santa Clara, California)
INVENTOR(S)	Daniel Orringer (Ann Arbor, Michigan); Christian Freudiger (San Carlos, California); Jay Trautman (Los Altos, California); Andrew Kelly (Boise, Idaho)
ABSTRACT	Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.
FILED	Friday, September 23, 2016
APPL NO	15/762904
ART UNIT	2886 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 10/02 (20130101) A61B 10/04 (20130101) A61B 10/0283 (20130101) Original (OR) Class Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/44 (20130101) G01J 3/0205 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 2021/653 (20130101)
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10743941 — Method and system for trackerless image guided soft tissue surgery and applications of same

US 10743941	Miga
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee)
INVENTOR(S)	Michael I. Miga (Franklin, Tennessee)
ABSTRACT	Methods and systems for performing trackerless image guided soft tissue surgery. For a patient in need of brain surgery, pre-operative preparation for a patient is performed by generating a three-dimensional textured point cloud (TPC) for the patient's scalp surface, and registering the first three-dimensional TPC to a magnetic resonance (MR) model of the brain. During the surgery, an intra-operative cortical surface registration to the MR model is performed for the MR-to-cortical surface alignment. Then shift measurement and compensation to the MR model is performed by: performing absolute deformation measurement of the brain based on the MR model with the cortical surface registration, and obtaining shift correction to the MR model using the absolute deformation measurements. The shift correction may be used for adjusting an image guidance system (IGS) in the brain surgery.
FILED	Wednesday, November 23, 2016
APPL NO	15/359801
ART UNIT	3799 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 34/20 (20160201) Original (OR) Class A61B 90/39 (20160201) A61B 90/361 (20160201) A61B 2034/107 (20160201) A61B 2034/2065 (20160201) A61B 2090/363 (20160201) A61B 2090/374 (20160201) A61B 2090/395 (20160201) A61B 2090/3983 (20160201) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101)
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10744106 — Reversibly protected thiolated electrophilic fatty acids as prodrugs

US 10744106	Freeman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Bruce A. Freeman (Pittsburgh, Pennsylvania); Nicholas Khoo (Pittsburgh, Pennsylvania); Francisco Jose Schopfer (Pittsburgh, Pennsylvania); Steven Woodcock (Pittsburgh, Pennsylvania)
ABSTRACT	Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
FILED	Wednesday, October 04, 2017
APPL NO	16/339702
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/20 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 3/04 (20180101) A61P 13/12 (20180101) A61P 29/00 (20180101)
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10744116 — Detection and treatment of anti-PD-1 therapy resistant metastatic melanomas

US 10744116	Lo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Roger S. Lo (Los Angeles, California); Willy Hugo (Los Angeles, California); Antoni Ribas (Los Angeles, California); Jesse Zaretsky (Santa Monica, California)
ABSTRACT	Methods of predicting or detecting sensitivity to therapeutic effects of anti-PD-1 therapy in a patient suffering from melanoma, as well as for selecting somatic mutanomes and transcriptomes of melanoma biopsies. A tumor sample obtained from the patient is assayed for a measure of anti-PD-1 therapy sensitivity via, for example, whole transcriptome sequencing, antibody based protein quantifications, mass spectrometry based protein quantification, targeted mRNA sequencing, real-time RT-PCR, Sanger sequencing, targeted sequencing and/or whole exome/genome sequencing. Samples are selected that exhibit a higher first enrichment similarity score and/or a lower second enrichment similarity score, and/or at least one measure of sensitivity. A patient whose sample was selected herein as a candidate for anti-PD-1 therapy is thereby identified. The method of the invention can further comprise treating the patient with anti-PD-1 therapy, optionally in conjunction with combinatorial therapy.
FILED	Thursday, March 16, 2017
APPL NO	16/084911
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/385 (20130101) Original (OR) Class A61K 31/427 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 20/00 (20190201) G16B 25/00 (20190201) G16B 25/10 (20190201)
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10744119 — Inhibitors of the malarial GST

US 10744119	Serrano-Brizuela et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR)
APPLICANT(S)	Adelfa E. Serrano-Brizuela (San Juan, Puerto Rico); Emilee E. Colón-Lorenzo (San Juan, Puerto Rico); Jürgen Bosh (Baltimore, Maryland); Daisy Colón-López (Baltimore, Maryland)
ASSIGNEE(S)	University of Puerto Rico (San Juan, Puerto Rico)
INVENTOR(S)	Adelfa E. Serrano-Brizuela (San Juan, Puerto Rico); Emilee E. Colón-Lorenzo (San Juan, Puerto Rico); Jürgen Bosh (Baltimore, Maryland); Daisy Colón-López (Baltimore, Maryland)
ABSTRACT	A compound to inhibit a glutathione S-transferase (GST) enzyme activity having formula (I). The compound having formula (I) is an antimalarial compound that inhibits the growth of the Plasmodium spp parasites. The compound of the present invention inhibits the growth of a malarial parasite by 50%.
FILED	Tuesday, December 15, 2015
APPL NO	14/970515
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/53 (20130101) A61K 31/166 (20130101) A61K 31/426 (20130101) A61K 31/506 (20130101) A61K 31/522 (20130101) A61K 31/4184 (20130101) Original (OR) Class A61K 31/4375 (20130101) A61K 31/4439 (20130101) A61K 31/4709 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101)
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10744129 — Therapy of small-cell lung cancer (SCLC) with a topoisomerase-I inhibiting antibody-drug conjugate (ADC) targeting Trop-2

US 10744129	Goldenberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Immunomedics, Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	Immunomedics, Inc. (Morris Plains, New Jersey)
INVENTOR(S)	David M. Goldenberg (Mendham, New Jersey); Serengulam V. Govindan (Summit, New Jersey)
ABSTRACT	The present invention relates to treatment of SCLC with therapeutic ADCs comprising a drug attached to an anti-Trop-2 antibody or antigen-binding antibody fragment. Preferably, the drug is SN-38. More preferably, the antibody is an hRS7 antibody and the ADC is sacituzumab govitecan. The ADC may be administered at a dosage of between 4 mg/kg and 16 mg/kg, preferably 4, 6, 8, 9, 10, 12, or 16 mg/kg, mostly preferably 8 to 10 mg/kg. When administered at specified dosages and schedules, the ADC can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy. Surprisingly, the ADC is effective to treat cancers that are refractory to or relapsed from irinotecan or topotecan. Preferably, the ADC is administered as a combination therapy with one or more other anti-cancer treatments, such as carboplatin or cisplatinum.
FILED	Wednesday, February 21, 2018
APPL NO	15/901691
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/481 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/337 (20130101) A61K 31/454 (20130101) A61K 31/513 (20130101) A61K 31/555 (20130101) A61K 31/555 (20130101) A61K 31/675 (20130101) A61K 31/713 (20130101) A61K 31/4184 (20130101) A61K 31/4375 (20130101) A61K 31/4745 (20130101) Original (OR) Class A61K 31/7088 (20130101) A61K 33/24 (20130101) A61K 39/39558 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 47/6803 (20170801) A61K 47/6851 (20170801) A61K 47/6853 (20170801) A61K 2039/55 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) A61K 2039/545 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/30 (20130101) C07K 16/32 (20130101) C07K 16/303 (20130101) C07K 16/2803 (20130101) C07K 16/2833 (20130101) C07K 16/2887 (20130101) C07K 16/3007 (20130101) C07K 16/3015 (20130101) C07K 16/3023 (20130101) C07K 16/3061 (20130101) C07K 16/3092 (20130101) C07K 2317/24 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101)
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10744133 — Compound for anti-cancer therapy that acts by targeting GOF mutant p53 and stimulates p73 to restore the p53 pathway signaling

US 10744133	El-Deiry et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Wafik S. El-Deiry (Bryn Mawr, Pennsylvania); Shengliang Zhang (Jenkintown, Pennsylvania)
ABSTRACT	The invention includes compositions comprising NSC59984 or a derivative or analogue thereof and a pharmaceutically acceptable carrier. The invention further includes methods of treating or preventing cancer in a subject, comprising the step of administering to the subject the compositions contemplated within the invention.
FILED	Monday, April 29, 2019
APPL NO	16/396829
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Original (OR) Class Heterocyclic Compounds C07D 307/71 (20130101)
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10744148 — Methods of treating breast cancer that overexpress AKT kinase

US 10744148	Cheng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of South Florida (Tampa, Florida)
ASSIGNEE(S)
INVENTOR(S)	Jin Q. Cheng (Tampa, Florida); Said M. Sebti (Tampa, Florida)
ABSTRACT	This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.
FILED	Friday, April 14, 2017
APPL NO	15/487854
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/517 (20130101) A61K 31/5377 (20130101) A61K 31/7064 (20130101) Original (OR) Class A61K 31/7068 (20130101) A61K 31/7076 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57426 (20130101) G01N 2333/912 (20130101)
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10744157 — Anti-MICA antigen binding fragments, fusion molecules, cells which express and methods of using

US 10744157	Sentman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE TRUSTEES OF DARTMOUTH COLLEGE (New Hampshire, New Hampshire)
ASSIGNEE(S)	THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
INVENTOR(S)	Charles Sentman (Grantham, New Hampshire); Michael Battles (Canaan, New Hampshire)
ABSTRACT	Antigen binding fragments, chimeric antigen receptors, and bi-specific T-cell engagers having specificity for MICA and methods for using the same in the diagnosis and treatment of disorders associated with MICA and/or MICB expression are provided.
FILED	Friday, March 25, 2016
APPL NO	15/561748
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 47/6835 (20170801) A61K 51/1045 (20130101) A61K 51/1096 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2809 (20130101) C07K 16/2833 (20130101) C07K 16/2851 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101)
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10744161 — Vivo iron labeling of stem cells and tracking these labeled stem cells after their transplantation

US 10744161	Daldrup-Link
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Heike E. Daldrup-Link (San Francisco, California)
ABSTRACT	Intravenous ferumoxytol is used to effectively label mesenchymal stem cells (MSCs) in vivo and is used for in vivo tracking of stem cell transplants with magnetic resonance (MR) imaging. The method eliminates risk of contamination and biologic alteration of MSCs associated with ex-vivo-labeling procedures.
FILED	Saturday, September 23, 2017
APPL NO	15/713626
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 49/1863 (20130101) A61K 49/1896 (20130101)
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10744170 — Combination treatment

US 10744170	Bigner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Darell D. Bigner (Mebane, North Carolina); Matthias Gromeier (Durham, North Carolina); Smita Nair (Cary, North Carolina); Vidyalakshmi Chandramohan (Durham, North Carolina)
ABSTRACT	Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. Combination with immune checkpoint inhibitors increases the anti-tumor effect. Tumors of different types are susceptible to the combination treatment, including but not limited to melanoma, glioglastoma, renal cell carcinoma, prostate cancer, breast cancer, lung cancer, medulloblastoma, and colorectal cancer.
FILED	Friday, October 14, 2016
APPL NO	15/768147
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 35/768 (20130101) Original (OR) Class A61K 35/768 (20130101) A61K 39/13 (20130101) A61K 39/39 (20130101) A61K 39/39541 (20130101) A61K 39/39541 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/85 (20130101) C12N 2770/32621 (20130101) C12N 2770/32632 (20130101) C12N 2840/203 (20130101) Technologies for Adaptation to Climate Change Y02A 50/466 (20180101)
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10744171 — Sequential anti-cancer treatment

US 10744171	Bigner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Darell D. Bigner (Mebane, North Carolina); Matthias Gromeier (Durham, North Carolina); Annick Desjardins (Durham, North Carolina); Henry S. Friedman (Durham, North Carolina); Allan H. Friedman (Durham, North Carolina); John H. Sampson (Durham, North Carolina)
ABSTRACT	Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. Sequential treatment with the virus construct followed by chemotherapy drugs increases the anti-tumor effect. Tumors of different types are susceptible to the combination treatment, including but not limited to melanoma, glioblastoma, renal cell carcinoma, prostate cancer, breast cancer, lung cancer, medulloblastoma, and colorectal cancer.
FILED	Monday, March 20, 2017
APPL NO	16/086735
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/175 (20130101) A61K 31/175 (20130101) A61K 31/495 (20130101) A61K 31/495 (20130101) A61K 35/768 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 2770/32332 (20130101) C12N 2770/32371 (20130101) C12N 2840/203 (20130101) Technologies for Adaptation to Climate Change Y02A 50/465 (20180101)
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10744180 — Therapy and kit for the prevention and treatment of cystic fibrosis

US 10744180	Madden et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S)	TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
INVENTOR(S)	Dean R. Madden (Hanover, New Hampshire); Nicholas P. Gill (White River Junction, Vermont); Carrie Ann Davison (Florence, Alabama); Mark R. Spaller (White River Junction, Vermont)
ABSTRACT	Compositions, kits and methods for preventing or treating cystic fibrosis are provided, which include the use of a peptidomimetic that inhibits the interaction between CAL and mutant CFTR proteins.
FILED	Wednesday, November 22, 2017
APPL NO	15/820962
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/15 (20130101) A61K 31/655 (20130101) A61K 31/655 (20130101) A61K 38/04 (20130101) A61K 38/08 (20130101) Original (OR) Class A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/16 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 5/1013 (20130101) C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/4703 (20130101)
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10744193 — Immunogenic RSV polypeptides

US 10744193	Khurana et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland)
INVENTOR(S)	Surender Khurana (Clarksburg, Maryland); Hana Golding (Rockville, Maryland)
ABSTRACT	This invention provides immunogenic compositions comprising an immune stimulant and an respiratory syncytial virus (RSV) oligopeptide or an unglycosylated RSV polypeptide. The RSV oligopeptides are shown in SEQ ID NO: 3-33. The unglycosylated RSV polypeptide may consist essentially of the ectodomain of an RSV G protein, such as that shown in SEQ ID NO: 2 or the ectodomain of an RSV F protein such as the ectodomain of the F protein shown in SEQ ID NO: 39.
FILED	Thursday, February 18, 2016
APPL NO	15/562862
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/54 (20130101) A61K 2039/55 (20130101) A61K 2039/523 (20130101) A61K 2039/555 (20130101) A61K 2039/645 (20130101) A61K 2039/55566 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/18534 (20130101) C12N 2760/18571 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101)
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10744198 — Inorganic polyatomic oxyanions for protecting against antigenic damage during pathogen inactivation for vaccine production

US 10744198	Amanna et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Najít Technologies, Inc. (Beaverton, Oregon)
ASSIGNEE(S)	Najit Technologies, Inc. (Beaverton, Oregon)
INVENTOR(S)	Ian J. Amanna (Hillsboro, Oregon); Elizabeth A. Poore (Portland, Oregon)
ABSTRACT	Provided are methods for rapidly inactivating a pathogen, or for producing a vaccine composition containing an inactivated noninfectious pathogen having retained antigenicity and/or immunogenicity, comprising exposing the pathogen to a chemical inactivating agent (e.g., one or more chemical oxidizing, alkylating or crosslinking agents) in the presence of inorganic polyatomic oxyanions in an amount and for a time sufficient to render the pathogen noninfectious while enhancing retention of pathogen antigenicity and/or immunogenicity relative to that retained by contacting the pathogen with the chemical inactivating agent alone. The methods are broadly applicable to pathogens having RNA or DNA genomes (e.g., including viruses, bacteria, fungi, and parasites). Also provided are vaccine compositions (medicaments) containing a pathogen inactivated by exposure to a an inactivating agent in the presence of elevated concentrations of inorganic polyatomic oxyanions, and methods for eliciting an immune response in a subject by administering the vaccine compositions.
FILED	Wednesday, May 10, 2017
APPL NO	16/300541
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/02 (20130101) A61K 39/12 (20130101) A61K 39/105 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 39/275 (20130101) A61K 39/0283 (20130101) A61K 2039/521 (20130101) A61K 2039/5252 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16131 (20130101) C12N 2760/16134 (20130101) C12N 2760/16163 (20130101) C12N 2760/16171 (20130101) C12N 2770/24134 (20130101) C12N 2770/24163 (20130101) C12N 2770/24171 (20130101) C12N 2770/36134 (20130101) C12N 2770/36163 (20130101) C12N 2770/36171 (20130101) Technologies for Adaptation to Climate Change Y02A 50/47 (20180101) Y02A 50/383 (20180101) Y02A 50/386 (20180101) Y02A 50/388 (20180101)
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10744199 — Epstein-Barr virus vaccines

US 10744199	Kanekiyo et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The USA, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Masaru Kanekiyo (Chevy Chase, Maryland); Gary J. Nabel (Chestnut Hill, Massachusetts); Jeffrey Cohen (Silver Springs, Maryland); Wei Bu (Potomac, Maryland)
ABSTRACT	Vaccines are provided that elicit neutralizing antibodies to Epstein-Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.
FILED	Friday, October 10, 2014
APPL NO	15/028655
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/245 (20130101) Original (OR) Class A61K 2039/64 (20130101) A61K 2039/575 (20130101) A61K 2039/55505 (20130101) Peptides C07K 14/00 (20130101) C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 16/085 (20130101) C07K 2317/33 (20130101) C07K 2317/76 (20130101) C07K 2319/00 (20130101) C07K 2319/40 (20130101) C07K 2319/735 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16222 (20130101) C12N 2710/16234 (20130101) C12N 2710/16271 (20130101)
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10744203 — Bone fracture repair by targeting of agents that promote bone healing

US 10744203	Low et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana); University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana); University of Utah (Salt Lake City, Utah)
INVENTOR(S)	Stewart Andrew Low (West Lafayette, Indiana); Philip S. Low (West Lafayette, Indiana); Christopher Galliford (Silver Spring, Maryland); Jindrich Kopecek (Salt Lake City, Utah); Jiyan Yang (Salt Lake City, Utah)
ABSTRACT	Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.
FILED	Thursday, January 31, 2019
APPL NO	16/264364
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 31/404 (20130101) A61K 47/42 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/22 (20130101) A61L 27/54 (20130101) A61L 27/227 (20130101) A61L 2400/06 (20130101) A61L 2430/02 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/002 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/00 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101)
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10744209 — Biodegradable polymeric nanoparticle conjugates and use thereof

US 10744209	Ulman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)	NEW YORK UNIVERSITY (New York, New York)
INVENTOR(S)	Abraham Ulman (Brooklyn, New York); Bruce Cronstein (New York, New York); Linda Franks (Pelham, New York)
ABSTRACT	The present invention relates to a polymeric nanoparticle conjugate of formula (I). The present invention also relates to pharmaceutical compositions including these polymeric nanoparticle conjugates, and methods of preparation and use thereof.
FILED	Friday, November 11, 2016
APPL NO	15/775575
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/7076 (20130101) A61K 38/00 (20130101) A61K 38/18 (20130101) A61K 47/593 (20170801) A61K 47/6937 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 17/06 (20180101) A61P 19/02 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 14/575 (20130101)
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10744211 — Trifunctional and completely clearable specific targeting agents and methods thereof

US 10744211	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Guozheng Liu (Worcester, Massachusetts); Shuping Dou (Worcester, Massachusetts)
ABSTRACT	The invention provides a novel trifunctional targeting construct and related compositions and methods that are useful in therapeutic, diagnostic (including imaging) of various biological and/or pathological conditions and diseases such as cancers and diabetes. The trifunctional targeting construct of the invention provides enhanced clearing step and reduced non-specific background via complete clearance of undesired antibody conjugates.
FILED	Wednesday, March 28, 2018
APPL NO	15/939230
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/6898 (20170801) A61K 49/00 (20130101) Original (OR) Class A61K 51/065 (20130101) A61K 51/0495 (20130101)
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10744212 — Topical application of nerve labeling dyes for image-guided surgery

US 10744212	Tan Hehir et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
ASSIGNEE(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
INVENTOR(S)	Cristina Abucay Tan Hehir (Niskayuna, New York); Tiberiu Mircea Siclovan (Rexford, New York); Victoria Eugenia Cotero (Watervliet, New York)
ABSTRACT	The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.
FILED	Monday, March 14, 2016
APPL NO	15/069198
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0068 (20130101) A61B 5/0071 (20130101) A61B 5/0084 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 47/10 (20130101) A61K 47/22 (20130101) A61K 47/32 (20130101) A61K 49/0021 (20130101) Original (OR) Class A61K 49/0071 (20130101)
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10744214 — Method of diagnosing and/or monitoring therapy of atherosclerosis

US 10744214	Norenberg
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S)	STC.UNM (Albuquerque, New Mexico)
INVENTOR(S)	Jeffrey P. Norenberg (Albuquerque, New Mexico)
ABSTRACT	The present invention is directed to novel non-invasive diagnostic took to dispose numerous disease states and/or conditions. The presets invention, represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. The methods described herein are able to diagnose, treat and/or monitor the therapy of numerous diseases and conditions including atherosclerosis, atherothrombosis, cerebral vascular disease, cerebral ischemia, cerebral infarct and meningitis as well as pneumonitis, pericarditis, multiple sclerosis, lupus erythematosus and pancreatitis, among others.
FILED	Wednesday, December 28, 2016
APPL NO	16/065393
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/22 (20130101) A61K 49/106 (20130101) A61K 51/0453 (20130101) A61K 51/0482 (20130101) Original (OR) Class
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10744228 — Methacrylated devitalized cartilage and devitalized cartilage particles

US 10744228	Detamore et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	The University of Kansas (Lawrence, Kansas)
ASSIGNEE(S)	The University of Kansas (Lawrence, Kansas)
INVENTOR(S)	Michael Detamore (Lawrence, Kansas); Emily Beck (Lawrence, Kansas)
ABSTRACT	An implantable composition can include methacrylated solubilized devitalized cartilage (MeSDVC) with or without devitalized cartilage (DVC) particles. These compositions can be hydrogel precursors. After implantation, the MeSDVC may be crosslinked so as to form a hydrogel. The crosslinked hydrogel can include the DVC particles. A hydrogel precursor matrix (e.g., not crosslinked) can include a crosslinkable substance that can be crosslinked into a hydrogel, where DVC particles are included in the precursor matrix. The hydrogel precursor matrix can be located in a tissue defect site, such as a hole or recess in a cartilage or bone, and then crosslinked into a hydrogel that has the DVC particles therein.
FILED	Thursday, September 01, 2016
APPL NO	15/254709
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/48 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/3612 (20130101) Original (OR) Class A61L 27/3687 (20130101) A61L 27/3691 (20130101) A61L 2400/06 (20130101) A61L 2430/06 (20130101)
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10744233 — Crystallization inhibitor compositions for implantable urological devices

US 10744233	Taton
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Innovative Surface Technologies, Inc. (St. Paul, Minnesota)
ASSIGNEE(S)	Innovative Surface Technologies, Inc. (St. Paul, Minnesota)
INVENTOR(S)	Kristin Taton (Little Canada, Minnesota)
ABSTRACT	Inventive concepts relate generally to the field of implantable urological devices, and more particularly to compositions that inhibit crystallization of urine components. Described are implantable urological devices including a surface and a crystallization inhibitor composition, the crystallization inhibitor composition including: (a) an inhibitor of urine component crystallization in combination with a biodegradable polymer, or a polyalkene homopolymer or copolymer, or (b) a biodegradable polymer that includes an inhibitor of urine component crystallization, wherein the crystallization inhibitor composition provides controlled release of the inhibitor of urine component crystallization from the surface of the device into a subject. Methods of making the implantable urological devices are also described.
FILED	Friday, February 24, 2017
APPL NO	16/079218
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 9/0092 (20130101) A61K 9/5031 (20130101) A61K 31/194 (20130101) A61K 31/194 (20130101) A61K 31/765 (20130101) A61K 38/19 (20130101) A61K 38/19 (20130101) A61K 38/1875 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/06 (20130101) A61L 29/06 (20130101) A61L 29/16 (20130101) Original (OR) Class A61L 29/042 (20130101) A61L 29/085 (20130101) A61L 29/145 (20130101) A61L 29/148 (20130101) A61L 31/06 (20130101) A61L 31/06 (20130101) A61L 31/10 (20130101) A61L 31/16 (20130101) A61L 2300/216 (20130101) A61L 2300/252 (20130101) A61L 2300/404 (20130101) A61L 2300/604 (20130101) A61L 2300/606 (20130101) A61L 2300/608 (20130101) A61L 2400/02 (20130101) Compositions of Macromolecular Compounds C08L 67/04 (20130101) C08L 67/04 (20130101)
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10744251 — Double fiber bundle dialyzer

US 10744251	Mishkin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	MIRIMEDICAL LLC (Gaithersburg, Maryland)
ASSIGNEE(S)	MIRIMEDICAL LLC (Potomac, Maryland)
INVENTOR(S)	Gary Mishkin (Gaithersburg, Maryland); Mark Scott Goodin (Solon, Ohio)
ABSTRACT	A dialyzer composed of: first and second dialyzation chambers, and an intermediate chamber interposed between the first and second dialyzation chambers. Each of the chambers has a respective one of a blood inlet or outlet and a dialysate inlet or outlet arranged so that blood and dialysate flow in counter-current to one another in both chambers. The intermediate chamber is connected to form a dialysate-free blood flow passage between the blood chambers and is configured to maintain a substantially uniform blood flow.
FILED	Thursday, February 12, 2015
APPL NO	15/550866
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/16 (20130101) A61M 1/1633 (20140204) Original (OR) Class A61M 1/3417 (20140204) A61M 2230/207 (20130101) Separation B01D 63/043 (20130101) B01D 2313/20 (20130101) B01D 2313/21 (20130101) B01D 2319/06 (20130101) B01D 2319/022 (20130101)
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10744328 — System for generating and applying waveform shapes for treating neurological disorders optimized for energy efficiency

US 10744328	Grill et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Warren M. Grill (Chapel Hill, North Carolina); Amorn Wongsarnpigoon (Chapel Hill, North Carolina)
ABSTRACT	Systems and methods for stimulation of neurological tissue apply a stimulation waveform that is derived by a developed genetic algorithm (GA), which may be coupled to a computational model of extracellular stimulation of a mammalian myelinated axon. The waveform is optimized for energy efficiency.
FILED	Monday, July 17, 2017
APPL NO	15/651072
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0529 (20130101) A61N 1/3606 (20130101) A61N 1/36146 (20130101) Original (OR) Class A61N 1/36175 (20130101)
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10745354 — Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols

US 10745354	Stoltz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Brian M. Stoltz (San Marino, California); Aurapat Ngamnithiporn (Pasadena, California); Carina I. Jette (Pasadena, California); Shoshana Bachman (Las Vegas, Nevada); Scott C. Virgil (Pasadena, California); Sebastian Lackner (Hamburg, Germany)
ABSTRACT	The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.
FILED	Monday, July 15, 2019
APPL NO	16/511138
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2409 (20130101) B01J 2231/4272 (20130101) B01J 2531/004 (20130101) B01J 2531/847 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 37/04 (20130101) C07B 2200/07 (20130101) Heterocyclic Compounds C07D 211/76 (20130101) C07D 211/86 (20130101) Original (OR) Class C07D 309/30 (20130101) C07D 309/32 (20130101) C07D 407/06 (20130101) C07D 409/06 (20130101)
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10745386 — Coumarin based HSP90 inhibitors with urea and ether substituents

US 10745386	Blagg et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Kansas (Lawrence, Kansas)
ASSIGNEE(S)	UNIVERSITY OF KANSAS (Lawrence, Kansas)
INVENTOR(S)	Brian S. J. Blagg (Lawrence, Kansas); Huiping Zhao (Lawrence, Kansas)
ABSTRACT	Compounds of the formulas: wherein: R₁-R₄, X₁, Y₁, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.
FILED	Tuesday, June 26, 2018
APPL NO	16/018439
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/453 (20130101) A61K 31/496 (20130101) A61K 31/4025 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 311/16 (20130101) C07D 405/12 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 413/12 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101)
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10745439 — Kinase substrates and methods of use thereof

US 10745439	Parker et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Laurie Parker (Minneapolis, Minnesota); Laura Marholz (Minneapolis, Minnesota)
ABSTRACT	The invention provides kinase substrates and methods comprising their use.
FILED	Tuesday, March 20, 2018
APPL NO	15/926640
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 7/06 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/76 (20130101) G01N 33/573 (20130101) G01N 2333/912 (20130101) G01N 2500/04 (20130101)
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10745442 — Compstatin analogs with improved pharmacokinetic properties

US 10745442	Lambris et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	John D. Lambris (Philadelphia, Pennsylvania); Hongchang Qu (Carmel, Indiana); Daniel Ricklin (Therwil, Switzerland)
ABSTRACT	Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. The compounds comprise compstatin analogs in which the N-terminus contains an added or substituted component that improves (1) the peptide's binding affinity to C3 or its fragments, (2) the peptide's solubility in aqueous liquids, (3) the peptide's plasma stability, (4) the peptide's in vivo retention and/or (5) the peptide's bioavailability, as compared with an unmodified compstatin peptide under equivalent conditions. Pharmaceutical compositions and methods of using the compounds are also disclosed.
FILED	Tuesday, November 20, 2018
APPL NO	16/196948
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/10 (20130101) A61K 38/12 (20130101) A61K 45/06 (20130101) A61K 47/542 (20170801) Peptides C07K 7/08 (20130101) Original (OR) Class C07K 7/64 (20130101)
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10745447 — Methods and compositions for antibody-evading virus vectors

US 10745447	Asokan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S)	Aravind Asokan (Chapel Hill, North Carolina); Mavis Agbandje-McKenna (Gainesville, Florida); Long Ping Victor Tse (Carrboro, North Carolina); Brittney Gurda (Collegeville, Pennsylvania)
ABSTRACT	The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.
FILED	Wednesday, September 28, 2016
APPL NO	15/763706
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) A61K 2039/507 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 16/081 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2810/6027 (20130101)
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10745453 — Compositions and methods for enhancing visual function

US 10745453	Isacoff et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Ehud Y. Isacoff (Berkeley, California); Michael H. Berry (Berkeley, California); Amy Holt (Berkeley, California); Meike Visel (El Cerrito, California); Autoosa Salari (Berkeley, California); John G. Flannery (Berkeley, California); Benjamin M. Gaub (Berkeley, California)
ABSTRACT	The present disclosure provides a method of restoring or enhancing visual function in an individual, the method comprising administering to the individual a nucleic acid comprising a nucleotide sequence encoding one or more of a medium wavelength cone opsin (MW-opsin), a long wavelength cone opsin (LW-opsin), and a short wavelength cone opsin (SW-opsin). One or more of the MW-opsin, LW-opsin, and SW-opsin is expressed in a retinal cell in the individual, thereby restoring or enhancing visual function.
FILED	Tuesday, February 19, 2019
APPL NO	16/279576
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 9/5138 (20130101) A61K 9/5153 (20130101) A61K 38/00 (20130101) A61K 48/0058 (20130101) A61K 48/0075 (20130101) A61K 48/0083 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/04 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 2750/14143 (20130101)
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10745458 — Non-standard insulin analogues

US 10745458	Weiss
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Michael A. Weiss (Cleveland, Ohio)
ABSTRACT	An insulin analogue comprises a B-chain polypeptide containing a cyclohexanylalanine substitution at position B24 and optionally containing additional amino-acid substitutions at positions A8, B28, and/or B29. A proinsulin analogue or single-chain insulin analogue contains a B domain containing a cyclohexanylalanine substitution at position B24 and optionally contains additional amino-acid substitutions at positions A8, B28, and/or B29. The analogue may be an analogue of a mammalian insulin, such as human insulin. A nucleic acid encoding such an insulin analogue is also provided. A method of lowering the blood sugar of a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. A method of semi-synthesis using an unprotected octapeptide by means of modification of an endogenous tryptic site by non-standard amino-acid substitutions.
FILED	Thursday, November 22, 2018
APPL NO	16/198815
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/04 (20130101) A61K 38/28 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Peptides C07K 14/62 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/09 (20130101) C12N 2330/00 (20130101)
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10745463 — Hyper-glycosylated antibodies with selective Fc receptor binding

US 10745463	Sundberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Eric J. Sundberg (Baltimore, Maryland); Beatriz Trastoy Bello (Bilbao, Spain)
ASSIGNEE(S)	UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland)
INVENTOR(S)	Eric J. Sundberg (Baltimore, Maryland); Beatriz Trastoy Bello (Bilbao, Spain)
ABSTRACT	Means for improving the effector functions of current immunotherapeutic antibodies through targeted hyper-glycosylation of the antibody Fc region are disclosed, as well as antibody variants having hyper-glycosylated Fc regions. Fc receptor-mediated effector functions have been shown to be a critical contributor to the efficacies of numerous therapeutic antibodies currently in clinical use. Targeted hyper-glycosylation of antibodies has the potential to significantly improve current immunotherapies for cancer.
FILED	Tuesday, November 18, 2014
APPL NO	15/037185
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/00 (20130101) Original (OR) Class C07K 16/32 (20130101) C07K 16/2887 (20130101) C07K 2317/41 (20130101) C07K 2317/52 (20130101) C07K 2317/71 (20130101) C07K 2317/92 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101)
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10745464 — Aldehyde tags, uses thereof in site-specific protein modification

US 10745464	Carrico et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Isaac S. Carrico (Stony Brook, New York); Brian L. Carlson (Richmond, California); Peng Wu (Berkeley, California); Carolyn Ruth Bertozzi (Berkeley, California)
ABSTRACT	The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
FILED	Wednesday, October 24, 2018
APPL NO	16/169292
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/37 (20130101) A61K 38/45 (20130101) A61K 38/215 (20130101) A61K 38/1825 (20130101) A61K 39/00 (20130101) Peptides C07K 1/006 (20130101) C07K 1/13 (20130101) C07K 1/1072 (20130101) C07K 14/00 (20130101) C07K 14/35 (20130101) C07K 14/565 (20130101) C07K 16/00 (20130101) Original (OR) Class C07K 16/46 (20130101) C07K 2317/24 (20130101) C07K 2317/40 (20130101) C07K 2317/52 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/13 (20130101) C12N 9/96 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) C12P 21/005 (20130101) Enzymes C12Y 208/02 (20130101)
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10745467 — VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders

US 10745467	Noelle et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire); KING'S COLLEGE LONDON (London, United Kingdom)
ASSIGNEE(S)	THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire); KING'S COLLEGE LONDON (London, United Kingdom)
INVENTOR(S)	Randolph J. Noelle (Plainfield, New Hampshire); Sabrina Ceeraz (Lebanon, New Hampshire); Isabelle LeMercier (Enfield, New Hampshire); Elizabeth Nowak (West Lebanon, New Hampshire); Janet Lines (London, United Kingdom)
ABSTRACT	The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig). The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions.
FILED	Monday, June 24, 2013
APPL NO	13/925094
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/21 (20130101) A61K 38/21 (20130101) A61K 38/212 (20130101) A61K 38/215 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 39/39558 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 14/70503 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 16/30 (20130101) C07K 16/2827 (20130101) C07K 2317/76 (20130101) C07K 2319/00 (20130101) C07K 2319/30 (20130101) Technologies for Adaptation to Climate Change Y02A 50/41 (20180101) Y02A 50/386 (20180101) Y02A 50/401 (20180101) Y02A 50/412 (20180101) Y02A 50/414 (20180101) Y02A 50/423 (20180101)
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10745474 — Methods of treating inflammation associated airway diseases and viral infections

US 10745474	Bose et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Washington State University (Pullman, Washington); The Board of Regents of the University of Texas System (Austin, Texas)
ASSIGNEE(S)	Washington State University (Pullman, Washington); The Board of Regents of the University of Texas Systems (Austin, Texas)
INVENTOR(S)	Santanu Bose (Pullman, Washington); Philippe Tessier (Quebec, Canada)
ABSTRACT	The present disclosure provides methods of treating a pathogen-induced lung inflammation in a subject are provided in which an anti-S100A9 antibody is administered to a subject. Methods of treating a respiratory virus infection by administering an anti-S100A9 antibody are also provided.
FILED	Tuesday, May 22, 2018
APPL NO	15/986382
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/24 (20130101) Original (OR) Class C07K 2317/76 (20130101)
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10745479 — TM4SF1 binding proteins and methods of using same

US 10745479	Jaminet et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
INVENTOR(S)	Shou-Ching S. Jaminet (Cambridge, Massachusetts); Harold F. Dvorak (Newton Center, Massachusetts)
ABSTRACT	This present invention relates to compounds (e.g., TM4SF1 binding proteins, e.g., anti-TM4SF1 antibodies) that specifically bind to a polypeptide at an epitope including an amino acid sequence of SEQ ID NO: 1. In particular, the compounds of the invention are capable of being internalized into a TM4SF1-expressing cell (e.g., a tumor cell or an angiogenic vasculature endothelial cell) following binding to the epitope of including the amino acid sequence of SEQ ID NO: 1. The invention also provides methods of treating a subject having a disorder associated with pathological angiogenesis with the compounds of the invention.
FILED	Tuesday, November 06, 2018
APPL NO	16/181674
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/6849 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/28 (20130101) Original (OR) Class C07K 16/30 (20130101) C07K 2317/14 (20130101) C07K 2317/34 (20130101) C07K 2317/51 (20130101) C07K 2317/77 (20130101) C07K 2317/92 (20130101) C07K 2317/515 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/6893 (20130101) G01N 2333/705 (20130101) G01N 2800/7014 (20130101)
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10745483 — Therapeutic peptides

US 10745483	Wucherpfennig et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S)	Kai W. Wucherpfennig (Brookline, Massachusetts); Glenn Dranoff (Sudbury, Massachusetts); F. Stephen Hodi (Framingham, Massachusetts); Bettina Franz (Orem, Utah); Kenneth F. May, Jr. (Bozeman, Montana); Christopher Harvey (Boston, Massachusetts)
ABSTRACT	The present disclosure provides, in part, compositions comprising peptides immuno specifically binds to defined binding partners, wherein the peptides comprise at least complementarity determining regions relating to the complementarity regions shown in Table 1.
FILED	Friday, March 14, 2014
APPL NO	14/776968
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/12 (20130101) A61K 38/15 (20130101) A61K 38/15 (20130101) A61K 39/39558 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Peptides C07K 16/30 (20130101) C07K 16/2833 (20130101) Original (OR) Class C07K 16/3015 (20130101) C07K 16/3023 (20130101) C07K 16/3053 (20130101) C07K 16/3061 (20130101) C07K 16/3069 (20130101) C07K 2317/21 (20130101) C07K 2317/34 (20130101) C07K 2317/56 (20130101) C07K 2317/73 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101)
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10745673 — Heme protein catalysts for carbon-boron bond formation in vitro and in vivo

US 10745673	Kan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	S. B. Jennifer Kan (Pasadena, California); Xiongyi Huang (Pasadena, California); Kai Chen (Pasadena, California)
ABSTRACT	Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the presence of a heme protein, e.g., a cytochrome c, a cytochrome P450, a globin, a protoglobin, a nitric oxide dioxygenase, a peroxidase, or a catalase, or a variant thereof, under conditions sufficient to form the organoboron product. Reaction mixtures for producing organoboron products are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming carbon-boron bonds.
FILED	Wednesday, March 07, 2018
APPL NO	15/914788
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0053 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/10 (20130101) C12P 17/12 (20130101) Enzymes C12Y 109/03001 (20130101)
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10745677 — Editing of CCR5 receptor gene to protect against HIV infection

US 10745677	Maianti et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Juan Pablo Maianti (Revere, Massachusetts); David R. Liu (Lexington, Massachusetts)
ABSTRACT	Provided herein are systems, compositions, and methods of introducing protective and/or loss-of-function variants of CCR5 and CCR2. Variants may be introduced using a CRISPR/Cas9-based nucleobase editor or other guide nucleotide sequence-programmable DNA binding protein domain-based fusion protein described herein. Further provided herein are compositions and methods of preventing and treating conditions related to HIV infection and progression as well as to AIDS.
FILED	Friday, December 22, 2017
APPL NO	15/852891
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/7158 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 15/102 (20130101) C12N 15/1138 (20130101) C12N 2310/20 (20170501) C12N 2740/16062 (20130101) Enzymes C12Y 301/21 (20130101) C12Y 305/04001 (20130101)
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10745688 — Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption

US 10745688	Scharenberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Dental and Craniofacial Research (NIDCR) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Seattle Children's Hospital (Seattle, Washington)
ASSIGNEE(S)	SEATTLE CHILDREN'S RESEARCH INSTITUTE (Seattle, Washington)
INVENTOR(S)	Andrew M. Scharenberg (Seattle, Washington); Michael T. Certo (Seattle, Washington); Kamila Sabina Gwiazda (Seattle, Washington)
ABSTRACT	The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.
FILED	Wednesday, July 20, 2016
APPL NO	15/215428
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) A61K 38/45 (20130101) A61K 38/45 (20130101) A61K 38/52 (20130101) A61K 38/52 (20130101) A61K 38/465 (20130101) A61K 38/465 (20130101) A61K 2035/124 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/90 (20130101) C12N 9/1252 (20130101) C12N 15/62 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2800/80 (20130101) C12N 2840/203 (20130101)
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10745689 — Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption

US 10745689	Scharenberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Dental and Craniofacial Research (NIDCR) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Seattle Children's Hospital (Seattle, Washington)
ASSIGNEE(S)	SEATTLE CHILDREN'S RESEARCH INSTITUTE (Seattle, Washington)
INVENTOR(S)	Andrew M. Scharenberg (Seattle, Washington); Michael T. Certo (Seattle, Washington); Kamila Sabina Gwiazda (Seattle, Washington)
ABSTRACT	The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.
FILED	Wednesday, July 20, 2016
APPL NO	15/215461
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) A61K 38/45 (20130101) A61K 38/45 (20130101) A61K 38/52 (20130101) A61K 38/52 (20130101) A61K 38/465 (20130101) A61K 38/465 (20130101) A61K 2035/124 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/90 (20130101) C12N 9/1252 (20130101) C12N 15/62 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2800/80 (20130101) C12N 2840/203 (20130101)
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10745690 — Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption

US 10745690	Scharenberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Dental and Craniofacial Research (NIDCR) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Seattle Children's Hospital (Seattle, Washington)
ASSIGNEE(S)	SEATTLE CHILDREN'S HOSPITAL (Seattle, Washington)
INVENTOR(S)	Andrew M. Scharenberg (Seattle, Washington); Michael T. Certo (Seattle, Washington); Kamila Sabina Gwiazda (Seattle, Washington); David J. Rawlings (Seattle, Washington)
ABSTRACT	The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.
FILED	Friday, May 25, 2018
APPL NO	15/990024
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) A61K 38/45 (20130101) A61K 38/45 (20130101) A61K 38/52 (20130101) A61K 38/52 (20130101) A61K 38/465 (20130101) A61K 38/465 (20130101) A61K 2035/124 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/90 (20130101) C12N 9/1252 (20130101) C12N 15/62 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2800/80 (20130101) C12N 2840/203 (20130101)
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10745705 — Ribosome-mediated incorporation of peptides and peptidomimetics

US 10745705	Hecht et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	ARIZON BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	ARIZON BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S)	Sidney Hecht (Phoenix, Arizona); Larisa (Liza) Dedkova (Scottsdale, Arizona); Rumit Maini (Tempe, Arizona); Sandipan Roy Chowdhury (Tempe, Arizona); Rakesh Paul (Baltimore, Maryland)
ABSTRACT	Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
FILED	Friday, January 22, 2016
APPL NO	15/545275
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Heterocyclic Compounds C07D 263/34 (20130101) C07D 277/593 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/003 (20130101) C12N 15/11 (20130101) C12N 15/67 (20130101) Original (OR) Class Enzymes C12Y 105/01003 (20130101)
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10745714 — RNA-guided gene editing and gene regulation

US 10745714	Gersbach et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA) NIH Office of the Director (NIHOD) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Charles A. Gersbach (Durham, North Carolina); Isaac B. Hilton (Durham, North Carolina); Pablo Perez-Pinera (Urbana, Illinois); Ami M. Kabadi (Greensboro, North Carolina); Pratiksha I. Thakore (Durham, Illinois); David G. Ousterout (Raleigh, North Carolina); Joshua B. Black (Durham, North Carolina)
ABSTRACT	Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
FILED	Tuesday, May 29, 2018
APPL NO	15/991333
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/005 (20130101) A61K 48/0058 (20130101) Peptides C07K 14/4708 (20130101) C07K 2319/71 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2740/16043 (20130101) C12N 2800/40 (20130101) C12N 2840/20 (20130101) Enzymes C12Y 301/00 (20130101)
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10745728 — Applications for biversal nucleoside analogs

US 10745728	Benner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Steven A Benner (Gainesville, Florida); Hyo-Joong Kim (Gainesville, Florida); Zunyi Yang (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S)	Steven A Benner (Gainesville, Florida); Hyo-Joong Kim (Gainesville, Florida); Zunyi Yang (Gainesville, Florida)
ABSTRACT	This invention relates to the use of analogs of purines that have two tautomeric forms, one formally complementary to thymidine, the other formally complementary to cytidine, and analogs of pyrimidines that have two tautomeric forms, one formally complementary to guanosine, the other formally complementary to adenosine. These uses include the polymerase chain reaction amplification of targets having polymorphisms in primer binding sites and ligation.
FILED	Monday, August 27, 2018
APPL NO	16/113766
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/04 (20130101) C07H 21/02 (20130101) C07H 21/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101)
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10745730 — Modified bacterial protein expression system

US 10745730	Gottesman
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University of the City of New York (New York, New York)
INVENTOR(S)	Maxwell Gottesman (New York, New York)
ABSTRACT	The present invention describes host cells for reliable, high yield recombinant protein production, including unstable proteins. The present host cell (e.g., a bacterial cell) is deficient in at least one protease (or a subunit of a protease) such as Clp or ClpP. The host cell may also contain an expression vector that encodes a protein or polypeptide for overexpression.
FILED	Wednesday, September 28, 2016
APPL NO	15/764070
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Peptides C07K 14/245 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) C12N 15/70 (20130101) C12N 15/102 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class
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10745737 — Methods and reagents for glycoproteomics

US 10745737	Lee et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Richard S. Lee (Weston, Massachusetts); Hui Zhou (Newton, Massachusetts)
ABSTRACT	Methods, reagents, and kits for the reversible immobilization of glycoproteins to a solid support, the release and capture of a glycan portion of the glycoprotein, and the subsequent release and capture of the polypeptide portion of the glycoprotein are provided. The disclosure also provides suitable solid support materials, surface chemistries, and devices for use in the disclosed methods. The methods, reagents, kits, and devices provided herein are useful for the analysis of protein glycosylation, for example, in a diagnostic context, in the context of proteoglycomics, and in the context of producing glycosylated proteins for therapeutic purposes.
FILED	Thursday, November 07, 2013
APPL NO	14/441562
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 2333/98 (20130101) G01N 2333/4728 (20130101) G01N 2440/38 (20130101) G01N 2570/00 (20130101)
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10745739 — Enhanced throughput mineral coatings for optimization of stem cell behavior

US 10745739	Murphy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	William L. Murphy (Waunakee, Wisconsin); Siyoung Choi (Ithaca, New York); Xiaohua Yu (Madison, Wisconsin)
ABSTRACT	Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavior using mineral coatings that allow for the enhanced transfection of cells. The mineral coatings bind polynucleotides and provide a source of calcium and phosphate ions to enhance transfection. The present disclosure also provides a high throughput platform for screening non-viral transfection of cells. The methods of the present disclosure also provide an advantageous polynucleotide delivery platform because the mineral coatings may be deposited on various medical device materials after being specifically developed using the high throughput screening platform.
FILED	Monday, March 12, 2018
APPL NO	15/918357
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Original (OR) Class
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10745744 — HiC: method of identifying interactions between genomic loci

US 10745744	Dekker et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts)
INVENTOR(S)	Job Dekker (Princeton, Massachusetts); Erez Lieberman Aiden (Cambridge, Massachusetts); Nynke Van Berkum (NW The Hague, Netherlands); Andreas Gnirke (Wellesley, Massachusetts); Eric Lander (Cambridge, Massachusetts); Chad Nusbaum (Newton, Massachusetts); Louise Williams (Reading, Massachusetts); Alexandre Melnikov (Bellingham, Massachusetts); Georgia Giannoukos (Cambridge, Massachusetts)
ABSTRACT	The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.
FILED	Thursday, June 15, 2017
APPL NO	15/624077
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6837 (20130101) Original (OR) Class
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10745746 — Specific nucleic acid amplification with compounded selectivity

US 10745746	Chen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Xi Chen (Newton, Massachusetts); David Yu Zhang (Houston, Texas); Peng Yin (Brookline, Massachusetts)
ABSTRACT	The present disclosure provides, in various aspects and embodiments, methods and compositions for selectively amplifying a rare target nucleic acid and/or suppressing amplification of non-target nucleic acids with sequences similar to the rare target nucleic acid. The methods and composition are useful, for example, for detecting rare alleles among a population of wild-type alleles.
FILED	Friday, July 18, 2014
APPL NO	14/905021
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6848 (20130101) C12Q 1/6848 (20130101) C12Q 1/6858 (20130101) Original (OR) Class C12Q 2525/161 (20130101) C12Q 2525/197 (20130101) C12Q 2537/1376 (20130101)
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10745759 — Methods and compositions for the prognosis and treatment of relapsed leukemia

US 10745759	Carroll et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	New York University (New York, New York)
ASSIGNEE(S)	NEW YORK UNIVERSITY (New York, New York)
INVENTOR(S)	William L. Carroll (Irvington, New York); Julia A. Meyer (New York, New York)
ABSTRACT	The present invention is directed to methods of prognosing relapsed leukemia in a subject. These methods are based on the detection of one or more relapse-specific gene mutations in a patient sample. The present invention further relates to methods of preventing and treating relapse leukemia in a subject based on the determined prognosis of the subject.
FILED	Tuesday, May 07, 2013
APPL NO	14/399467
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/573 (20130101) A61K 31/704 (20130101) A61K 31/7068 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101)
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10745762 — Method and system for synthesizing a target polynucleotide within a droplet

US 10745762	Abate et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Adam R. Abate (Daly City, California); Dennis Jay Eastburn (Burlingame, California); Adam R. Sciambi (San Francisco, California)
ABSTRACT	The disclosed embodiments relate to method, system and apparatus for synthesizing a target polynucleotide within a droplet. In an exemplary embodiment, the disclosure provides a method of synthesizing a target polynucleotide. The method includes the steps of: contacting a polynucleotide-containing component from a sample with lysis reagents in a droplet, the lysis reagents comprising an enzyme having protease activity, wherein the droplet is encapsulated with an immiscible carrier fluid; moving the droplet into a collection reservoir; incubating the droplet in the collection reservoir for a first duration and then inactivating the enzyme having protease activity; adding to the droplet a nucleic acid synthesis reagent to form a nucleic acid synthesis droplet in the immiscible carrier fluid to form a nucleic acid droplet; and synthesizing the target polynucleotide within the nucleic acid synthesis droplet.
FILED	Tuesday, February 19, 2019
APPL NO	16/279905
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 3/0807 (20130101) B01F 5/0652 (20130101) B01F 13/0062 (20130101) B01F 13/0076 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) B01L 7/52 (20130101) B01L 2200/0652 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2300/0883 (20130101) B01L 2300/1822 (20130101) B01L 2400/0415 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/686 (20130101) C12Q 1/6806 (20130101) C12Q 1/6806 (20130101) C12Q 1/6844 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2537/143 (20130101) C12Q 2563/159 (20130101) C12Q 2563/159 (20130101) C12Q 2565/629 (20130101) C12Q 2600/16 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101)
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10745764 — Methods to detect and genotype Cryptococcus species

US 10745764	Engelthaler et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (Phoenix, Arizona); ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (Flagstaff, Arizona)
ASSIGNEE(S)	The Translational Genomics Research Institiute (Phoenix, Arizona); Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona)
INVENTOR(S)	David Engelthaler (Flagstaff, Arizona); Elizabeth Driebe (Flagstaff, Arizona); Erin Kelley (Flagstaff, Arizona); Paul Keim (Flagstaff, Arizona)
ABSTRACT	Embodiments of the invention provide a method of genotyping a C. gattii sample, which can include forming a plurality of mixtures for nucleic amplification. The method can include amplification of specific sequences within the C. gattii genome that can provide definitive genotype information to distinguish between one or more types or subtypes of C. gattii.
FILED	Monday, June 11, 2018
APPL NO	16/005012
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101)
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10745767 — Compositions and methods for detecting hepatitis B virus

US 10745767	Linnen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	GEN-PROBE INCORPORATED (San Diego, California)
ASSIGNEE(S)	GEN-PROBE INCORPORATED (San Diego, California)
INVENTOR(S)	Jeffrey M. Linnen (Poway, California); Daniel P. Kolk (Ramona, California); Janel M. Dockter (San Diego, California); Damon K. Getman (Poway, California); Tadashi Yoshimura (Chiba, Japan); Martha K. Ho-Sing-Loy (San Diego, California); Reinhold B. Pollner (San Diego, California); Leslie A. Stringfellow (San Diego, California)
ABSTRACT	Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers that facilitate detection of very low levels of HBV nucleic acids.
FILED	Thursday, January 25, 2018
APPL NO	15/879921
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/703 (20130101) C12Q 1/706 (20130101) Original (OR) Class
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10745814 — Enzymatic nucleic acid synthesis

US 10745814	Kalhor et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Reza Kalhor (East Boston, Massachusetts); Henry Hung-yi Lee (Brookline, Massachusetts); George M. Church (Brookline, Massachusetts)
ABSTRACT	The present disclosure provides methods of activating an enzyme, such as error prone or template independent polymerase, using electricity to alter pH of a reaction zone and reaction site from an inactivating pH at which the enzyme is inactive to an activating pH at which the enzyme is active to add a nucleotide to an initiator or growing polymer chain. The activating pH can then be changed back to an inactivating pH and the process repeated as many times as desired to produce a target nucleic acid sequence.
FILED	Tuesday, May 09, 2017
APPL NO	16/099487
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2219/00653 (20130101) B01J 2219/00713 (20130101) B01J 2219/00722 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6844 (20130101) C12Q 1/6844 (20130101) C12Q 1/6844 (20130101) C12Q 2521/101 (20130101) C12Q 2523/307 (20130101) C12Q 2525/117 (20130101) C12Q 2527/119 (20130101) C12Q 2527/119 (20130101) C12Q 2527/125 (20130101) C12Q 2527/125 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/02 (20130101) C25B 3/04 (20130101) C25B 3/10 (20130101) Original (OR) Class
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10746637 — Aldehyde scavenging agent for retrieving elements from fixed tissue

US 10746637	Eriksen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	University of Houston System (Houston, Texas)
ASSIGNEE(S)	UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas)
INVENTOR(S)	Jason Eriksen (Houston, Texas); Craig Vollert (Houston, Texas); Steven Bark (Houston, Texas); Wilna Moree (Houston, Texas)
ABSTRACT	In some embodiments, the present disclosure pertains to a method for retrieving at least one molecular recognition element in a fixed tissue. In some embodiments the method comprises preparing a solution comprising at least one aldehyde-scavenging agent. In some embodiments, the method comprises contacting the fixed tissue with the solution. In some embodiments, the tissue is fixed with an aldehyde-based cross-linking agent. In some embodiments, a reaction of the aldehyde-scavenging agent with the aldehydes comprising the cross-linking agent retrieves the at least one molecular recognition element. In some embodiments, the at least one molecular recognition element comprises of amino acids, peptides, proteins, nucleic acids, carbohydrates, lipids, or a combination thereof. In some embodiments, the at least one aldehyde-scavenging agent comprises of beta-dicarbonyl compounds, mono or di-amide scavengers, ethyl alcohols, sulfur containing compounds, mercaptoethylamines, mercaptoethanols, hydrazines, ethanolamines, hydroxylamines, anilines, variation of amines, activated charcoal, phenols, or mixtures and combinations thereof.
FILED	Wednesday, January 09, 2019
APPL NO	16/243840
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 1/44 (20130101) G01N 33/6803 (20130101) G01N 33/6878 (20130101) G01N 2001/305 (20130101)
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10746706 — Photoacoustic physio-chemical tissue analysis

US 10746706	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Xueding Wang (Ann Arbor, Michigan); Cheri Deng (Ann Arbor, Michigan); Paul L. Carson (Ann Arbor, Michigan); Guan Xu (Ann Arbor, Michigan)
ABSTRACT	A method of performing a photoacoustic physio-chemical analysis is provided. The method includes performing one or more photoacoustic scans on a tissue to generate a plurality of photoacoustic signals. The photoacoustic signals are transformed into a frequency domain to form a power spectra. The method also includes generating a two dimensional (2D) physio-chemical spectrogram from the power spectra. A probe for performing a photoacoustic physio-chemical analysis is also provided.
FILED	Monday, January 05, 2015
APPL NO	15/108717
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0095 (20130101) A61B 2503/40 (20130101) A61B 2503/42 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/1702 (20130101) G01N 29/11 (20130101) G01N 29/46 (20130101) G01N 29/0654 (20130101) G01N 29/2418 (20130101) Original (OR) Class G01N 33/4833 (20130101) G01N 2021/1706 (20130101) G01N 2291/02475 (20130101)
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10746736 — Integrated functional and molecular profiling of cells

US 10746736	Varadarajan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas)
ASSIGNEE(S)	UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas)
INVENTOR(S)	Navin Varadarajan (Houston, Texas); Gabrielle Romain (Houston, Texas); Ivan Liadi (Houston, Texas); Victor Sendra (Cambridge, Massachusetts); Badrinath Roysam (Houston, Texas)
ABSTRACT	Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.
FILED	Monday, March 28, 2016
APPL NO	15/560018
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) G01N 33/56966 (20130101) Original (OR) Class G01N 2570/00 (20130101)
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10746738 — Claudin-1 peptide reagents and methods

US 10746738	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Thomas D. Wang (Ann Arbor, Michigan); Emily Rabinsky (Ann Arbor, Michigan); Bishnu P. Joshi (Ann Arbor, Michigan)
ABSTRACT	The present invention is directed to claudin-1-specific peptide reagents, methods for detecting pre-cancer (dysplasia), early cancer and/or cancer using the peptide reagents, and methods for targeting pre-cancerous (dysplastic) cells, and/or cancer cells using the peptide reagents.
FILED	Thursday, February 25, 2016
APPL NO	15/553645
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0056 (20130101) Peptides C07K 7/06 (20130101) C07K 16/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57419 (20130101) Original (OR) Class
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10746742 — Methods of viral neutralizing antibody epitope mapping

US 10746742	Nakai et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon)
ASSIGNEE(S)	OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon)
INVENTOR(S)	Hiroyuki Nakai (Portland, Oregon); Kei Adachi (Portland, Oregon)
ABSTRACT	Disclosed herein are methods of high-throughput mapping of viral neutralizing antibody epitopes. Also disclosed are in vitro immunoprecipitation-based adenoassociated virus Barcode-Seq-based methods of mapping viral neutralizing antibody epitopes. In some embodiments, a method of high-throughput mapping of viral NtAb conformational epitopes can be utilized, which may comprise HP scanning of mutant viral libraries, immunoprecipitation (IP), and/or next-generation sequencing (NGS) technology. In some embodiments, a method of identifying one or more dominant epitopes in a viral vector may comprise contacting a mutant capsid of a virus with serum from a subject previously exposed to the virus and immunopredpitating serum immunoglobulins from the serum. In various embodiments, the viral vector may be an AAV vector.
FILED	Friday, April 24, 2015
APPL NO	15/306429
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class
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10747899 — Techniques for determining whether an individual is included in ensemble genomic data

US 10747899	Shringarpure et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California)
INVENTOR(S)	Suyash Shringarpure (Mountain View, California); Carlos D. Bustamante (Emerald Hills, California)
ABSTRACT	Techniques to determine if an individual is a member of an ensemble contributing to combined genomic data include determining a site frequency spectrum (SFS) for alleles in the combined genomic data, and a number N of individuals contributing to the combined genomic data. Based on the SFS and N, both a number of queries NQ and a number of yeses NY are determined. NY is a number of yes responses to NQ queries, which indicates a particular likelihood that the individual is a member of the ensemble. Output is based on at least one of NQ and NY. For example, fewer than NQ queries from a single source are answered from a beacon. Alternatively, the likelihood that an individual is a member of the ensemble is determined based on responses to NQ queries about NQ different alleles present in the individual and NY.
FILED	Thursday, October 06, 2016
APPL NO	15/766611
ART UNIT	2433 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 16/00 (20190101) G06F 16/90335 (20190101) G06F 21/6245 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/40 (20190201) G16B 50/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101)
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10748410 — System and method for detecting hand hygiene compliance

US 10748410	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Nursing Research (NINR) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Microsensor Labs, LLC (Chicago, Illinois)
ASSIGNEE(S)	Microsensor Labs, LLC (Chicago, Illinois)
INVENTOR(S)	Peng Liu (Chicago, Illinois); Yang Liu (Beijing, China PRC); Jiapeng Huang (Louisville, Kentucky)
ABSTRACT	A system and method for detecting hand hygiene compliance is disclosed. Hand hygiene is important in various contexts, including hospital settings, home settings, work settings, and school settings. For example, a healthcare provider may wear a wristband, which may interact with a stationary controller that is integrated with or proximate to a hand cleaning agent dispenser. The interaction may be used to determine whether the healthcare provider has complied with hand hygiene protocols. Further, the wristband may be used to train healthcare providers or others (such as children) in proper hand hygiene. Further, the wristband may be used in other contexts, such as integrating hand hygiene monitoring and access control. Also, monitoring people when performing tasks, such as hygiene tasks, cooking, and moving about, may be beneficial to those with cognitive difficulties, such as dementia. A device for detecting the tasks being performed and providing reminders to the people regarding the tasks may help those with dementia.
FILED	Friday, August 30, 2019
APPL NO	16/557191
ART UNIT	2685 — Selective Communication
CURRENT CPC	Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 1/00 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/18 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10366 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/245 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/20 (20180101)
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10748450 — System, apparatus, and method for creating an interactive augmented reality experience to simulate medical procedures for pediatric disease education

US 10748450	Oley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	SPROUTEL, INC. (Providence, Rhode Island)
ASSIGNEE(S)	Sproutel, Inc. (Providence, Rhode Island)
INVENTOR(S)	Brian Oley (Jamaica Plain, Massachusetts); Hannah Chung (Providence, Rhode Island); Joel B. Schwartz (Providence, Rhode Island); Aaron J. Horowitz (Providence, Rhode Island)
ABSTRACT	An interactive augmented reality system for simulating medical procedures for pediatric disease education includes a plush toy having one or more patches disposed on a body of the plush toy in one or more corresponding locations each associated with an area of the body of the plush toy that is comparable to an area of a human body. An interactive medical procedure simulation logic section operable within a mobile device causes a particular patch within a series of live images to be scanned, and initiates an interactive augmented reality experience to simulate a medical procedure for pediatric disease education. Comfort is provided to children struggling with a disease. Children learn how to manage their chronic illness by enabling them to practice their medical procedures and receive feedback related to correct and incorrect care. A low-cost disease education delivery mechanism is provided directly to children through game-play.
FILED	Tuesday, November 28, 2017
APPL NO	15/824981
ART UNIT	3715 — Amusement and Education Devices
CURRENT CPC	Toys, e.g Tops, Dolls, Hoops or Building Blocks A63H 3/001 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/00 (20130101) G09B 23/30 (20130101) Original (OR) Class
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Department of Defense (DOD)

10744039 — Methods of making bioactive collagen wound care dressings

US 10744039	Hussain et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	Ension, Inc. (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	ENSION INC. (Butler, Pennsylvania)
INVENTOR(S)	Ali Hussain (Cape Coral, Florida); Patrick Cahalan (Cape Coral, Florida); Linda Cahalan (Cape Coral, Florida)
ABSTRACT	A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.
FILED	Monday, October 23, 2017
APPL NO	15/790851
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/00012 (20130101) Original (OR) Class A61F 13/00029 (20130101) A61F 2013/00604 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/39 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/325 (20130101) A61L 15/425 (20130101) A61L 27/20 (20130101) A61L 27/24 (20130101) A61L 31/044 (20130101) A61L 31/146 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/10 (20130101) B32B 2250/20 (20130101) Peptides C07K 14/78 (20130101)
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10744321 — Transcranial current stimulation system and virtual reality for treatment of PTSD or fears

US 10744321	Pilly et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Praveen K. Pilly (West Hills, California); Michael D. Howard (Westlake Village, California)
ABSTRACT	Described is a system for treating traumatic memories. During a wake stage, a virtual environment is displayed to a subject. A traumatic episode that may be similar to a traumatic memory of the subject is displayed to the user in the virtual environment in a benign setting. A transcranial current stimulation (tCS) controller applies a pattern of transcranial direct current stimulation (tDCS) to the subject during the traumatic episode, such that the traumatic memory in a benign setting is associated with the pattern of tDCS. During a sleep stage, if slow-wave sleep in the subject is detected via electroencephalogram (EEG) recordings, then in a first time period, the tCS controller may a transcranial alternating current stimulation (tACS) to the subject followed by a second time period without stimulation. In a third time period, the tCS controller may apply the pattern of tDCS to the subject. The sleep stage may be repeated until a desired weakening of the traumatic memory is reached.
FILED	Thursday, January 18, 2018
APPL NO	15/874866
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/048 (20130101) A61B 5/0476 (20130101) A61B 5/0478 (20130101) A61B 5/4812 (20130101) A61B 5/4836 (20130101) A61B 5/6814 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 21/00 (20130101) A61M 2021/0055 (20130101) A61M 2205/52 (20130101) A61M 2230/005 (20130101) A61M 2230/10 (20130101) A61M 2230/10 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/20 (20130101) A61N 1/0456 (20130101) A61N 1/0476 (20130101) A61N 1/36025 (20130101) Original (OR) Class A61N 1/36031 (20170801) Image Data Processing or Generation, in General G06T 11/60 (20130101) G06T 2210/41 (20130101)
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10744347 — Implants using ultrasonic waves for stimulating tissue

US 10744347	Maharbiz et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Michel M. Maharbiz (El Cerrito, California); Dongjin Seo (Albany, California); Konlin Shen (Oakland, California); Jose M. Carmena (Berkeley, California); Ryan Neely (El Cerrito, California); Elad Alon (Oakland, California); Jan Rabaey (Berkeley, California)
ABSTRACT	Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal. Further described are computer systems useful for operating one or more implantable devices, as well as methods of electrically stimulating a tissue.
FILED	Wednesday, May 01, 2019
APPL NO	16/401028
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0031 (20130101) A61B 5/076 (20130101) A61B 5/686 (20130101) A61B 5/4836 (20130101) A61B 6/4258 (20130101) A61B 8/48 (20130101) A61B 8/085 (20130101) A61B 8/0808 (20130101) A61B 8/0875 (20130101) A61B 2505/05 (20130101) A61B 2560/0219 (20130101) A61B 2562/12 (20130101) A61B 2562/028 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 39/0208 (20130101) A61M 2205/04 (20130101) A61M 2205/825 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/372 (20130101) A61N 1/0534 (20130101) A61N 1/3605 (20130101) A61N 1/3787 (20130101) A61N 1/37205 (20130101) A61N 5/1071 (20130101) A61N 7/02 (20130101) Original (OR) Class A61N 2005/1087 (20130101) A61N 2007/0021 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/025 (20130101) H02J 50/15 (20160201) H02J 50/90 (20160201)
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10744461 — Ultrafiltration membrane based on bacterial nanocellulose and graphene oxide

US 10744461	Singamaneni et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Srikanth Singamaneni (St. Louis, Missouri); Young-Shin Jun (St. Louis, Missouri); Qisheng Jiang (St. Louis, Missouri); Deoukchen Ghim (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Srikanth Singamaneni (St. Louis, Missouri); Young-Shin Jun (St. Louis, Missouri); Qisheng Jiang (St. Louis, Missouri); Deoukchen Ghim (St. Louis, Missouri)
ABSTRACT	The present disclosure is directed to ultrafiltration membranes based on bacterial nanocellulose and graphene oxide. In particular, the present disclosure is directed to the novel design and incorporation of membranes for realizing new, highly efficient, and environmentally-friendly anti-biofouling membranes for water purification.
FILED	Thursday, February 14, 2019
APPL NO	16/276106
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Separation B01D 61/145 (20130101) Original (OR) Class B01D 65/08 (20130101) B01D 67/0079 (20130101) B01D 67/0095 (20130101) B01D 69/06 (20130101) B01D 69/148 (20130101) B01D 71/08 (20130101) B01D 71/10 (20130101) B01D 71/024 (20130101) B01D 2323/40 (20130101) B01D 2325/02 (20130101) B01D 2325/48 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 1/00 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/10 (20130101) C02F 1/14 (20130101) C02F 1/444 (20130101) C02F 2303/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/22 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 70/10 (20180501) F24S 2080/017 (20180501) Technologies for Adaptation to Climate Change Y02A 20/212 (20180101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/59 (20151101) Y02P 20/134 (20151101) Y02P 20/136 (20151101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 10/37 (20150501)
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10744557 — Refractory metal core finishing technique

US 10744557	Cassells et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Systems Command (NAVAIR)
APPLICANT(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Dewight R. Cassells (East Hartford, Connecticut); Alan C. Barron (Jupiter, Florida); John P. Rizzo (Vernon, Connecticut); Gordon Miller Reed (Plantsville, Connecticut); Tracy A. Propheter-Hinckley (Manchester, Connecticut)
ABSTRACT	A refractory metal core (RMC) finishing method according to an exemplary aspect of the present disclosure includes, among other things, performing a plurality of finishing operations on a plurality of RMC samples, analyzing one or more properties of at least a portion of the plurality of RMC samples and selecting a combination of finishing operations for generating an RMC having desirable properties for manufacturing a part free from defects.
FILED	Tuesday, October 28, 2014
APPL NO	15/034612
ART UNIT	3726 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Foundry Moulding B22C 9/10 (20130101) B22C 9/18 (20130101) Original (OR) Class B22C 9/24 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/187 (20130101) F01D 9/02 (20130101) Non-positive-displacement Pumps F04D 29/324 (20130101) F04D 29/542 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/10 (20130101) F05D 2230/21 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/676 (20130101)
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10745107 — Rapid flap deflection for high lift transients

US 10745107	Ol et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S)	Michael V. Ol (Xenia, Ohio); Alberto Medina (Fairborn, Ohio)
ABSTRACT	A wing, a method of controlling lift on a wing, and a system to produce lift on a wing are provided. The wing may include a fore-element, an aft-element, a pivotable linkage that operatively connects the aft-element leading edge to the fore-element trailing edge in a span-wise direction, and an actuator. The actuator may deflect the aft-element through a predetermined deflection angle about the pivotable linkage relative to the fore-element within less than or equal to two convective periods. The method may include deflecting a span-wise flap through the deflection angle in less than or equal to two convective periods to produce high lift. The system may include a sensor to detect an input and a controller to deflect the span-wise flap of the wing by the deflection angle in not more than two convective periods based on the received input signal.
FILED	Wednesday, January 03, 2018
APPL NO	15/860913
ART UNIT	3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Ships or Other Waterborne Vessels; Equipment for Shipping B63B 1/28 (20130101) B63B 1/248 (20130101) Aeroplanes; Helicopters B64C 3/48 (20130101) B64C 9/28 (20130101) Original (OR) Class B64C 13/16 (20130101) B64C 13/30 (20130101)
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10745139 — Simultaneous dual engine bleed thermal management system

US 10745139	Retersdorf et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Hamilton Sundstrand Corporation (Charlotte, North Carolina)
ASSIGNEE(S)	HAMILTON SUNDSTRAND CORPORATION (Charlotte, North Carolina)
INVENTOR(S)	Alan Retersdorf (Avon, Connecticut); Tony Ho (Glastonbury, Connecticut)
ABSTRACT	An environmental control system of an aircraft includes at least one heat exchanger and a compression device arranged in fluid communication with the at least one heat exchanger. The compression device includes a plurality of components including a first component and a second component coupled by a shaft. A first bleed port is arranged in fluid communication with the first component and a second bleed port, distinct from the first bleed port, is arranged in fluid communication with the second component.
FILED	Wednesday, June 27, 2018
APPL NO	16/020449
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 13/02 (20130101) B64D 13/06 (20130101) Original (OR) Class B64D 2013/0611 (20130101) B64D 2013/0618 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 6/08 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/213 (20130101)
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10745320 — Compositions of matter comprising nanoparticles and non-conductive substrates

US 10745320	Thostenson
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) National Science Foundation (NSF) Department of Transportation (USDOT) Federal Highway Administration (FHWA) National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S)	University of Delaware (Newark, Delaware)
ASSIGNEE(S)	University of Delaware (Newark, Delaware)
INVENTOR(S)	Erik Thostenson (Newark, Delaware)
ABSTRACT	In various aspects, the processes disclosed herein may include the steps of inducing an electric field about a non-conductive substrate, and depositing functionalized nanoparticles upon the non-conductive substrate by contacting a nanoparticle dispersion with the non-conductive substrate, the nanoparticle dispersion comprising functionalized nanoparticles having an electrical charge, the electric field drawing the functionalized nanoparticles to the non-conductive substrate. In various aspects, the related composition of matter disclosed herein comprise functionalized nanoparticles bonded to a surface of a non-conductive fiber, the surface of the non-conductive fiber comprising a sizing adhered to the surface of the non-conductive fiber. This Abstract is presented to meet requirements of 37 C.F.R. § 1.72(b) only. This Abstract is not intended to identify key elements of the processes, and related apparatus and compositions of matter disclosed herein or to delineate the scope thereof.
FILED	Wednesday, August 09, 2017
APPL NO	15/672931
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/44 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) C08K 3/042 (20170501) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/4419 (20130101) C09D 7/61 (20180101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) C25D 13/12 (20130101) C25D 13/22 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/254 (20150115)
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10745386 — Coumarin based HSP90 inhibitors with urea and ether substituents

US 10745386	Blagg et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Kansas (Lawrence, Kansas)
ASSIGNEE(S)	UNIVERSITY OF KANSAS (Lawrence, Kansas)
INVENTOR(S)	Brian S. J. Blagg (Lawrence, Kansas); Huiping Zhao (Lawrence, Kansas)
ABSTRACT	Compounds of the formulas: wherein: R₁-R₄, X₁, Y₁, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.
FILED	Tuesday, June 26, 2018
APPL NO	16/018439
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/453 (20130101) A61K 31/496 (20130101) A61K 31/4025 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 311/16 (20130101) C07D 405/12 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 413/12 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101)
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10745701 — Methods of identifying and treating poor-prognosis cancers

US 10745701	Kang et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees Of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Yibin Kang (Princeton, New Jersey); Guohong Hu (Piscataway, New Jersey)
ABSTRACT	The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis by combating metastasis and abrogating chemoresistance in cancer cells. Embodiments of the present invention provide an objective means of prognostication regarding the long-term outcome of an incident of cancer, breast cancer in particular. Therapeutic modalities include immunotherapy and anti-sense therapy. Prognosis is determined by measuring the number of copies of the metadherin gene in the patient's cells.
FILED	Friday, December 21, 2018
APPL NO	16/230098
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/337 (20130101) A61K 31/704 (20130101) A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2320/30 (20130101) C12N 2320/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101)
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10746033 — Gas turbine engine component

US 10746033	Spangler et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Brandon W. Spangler (Vernon, Connecticut); Jose R. Paulino (Saco, Maine)
ABSTRACT	A component for a gas turbine engine includes at least one airfoil that has a radially inner end and a radially outer end. A platform includes a radially outer surface that is attached to the radially inner end of the airfoil. A radially inner side of the platform includes a forward surface and an aft surface. A pocket is recessed into at least one of the forward surface and the aft surface. A cover plate covers the pocket and a seal is attached to the cover plate.
FILED	Thursday, May 17, 2018
APPL NO	15/982396
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/187 (20130101) F01D 9/041 (20130101) Original (OR) Class F01D 11/001 (20130101) F01D 25/12 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/55 (20130101) F05D 2240/81 (20130101) F05D 2260/20 (20130101)
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10746034 — Airfoil for a turbo machine

US 10746034	Mielke et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Mark Joseph Mielke (Blanchester, Ohio); Heidi Stegemiller (Franklin, Ohio)
ABSTRACT	An airfoil assembly for a turbo machine, the airfoil assembly including an airfoil defining a leading edge and a trailing edge, and further defining ends separated along a span of the airfoil; a shaft extended from the end of the airfoil; and a button surrounding at least a portion of the end of the airfoil, the button comprising a composite material.
FILED	Wednesday, June 13, 2018
APPL NO	16/007289
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/042 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/321 (20130101) F05D 2240/12 (20130101) F05D 2240/91 (20130101) F05D 2260/00 (20130101) F05D 2300/43 (20130101)
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10746039 — Hydrostatic seal pinned cartridge

US 10746039	Chuong et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Life Cycle Management Center (AFLCMC)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	United Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Conway Chuong (Manchester, Connecticut); Tara L. D'Ambruoso (Oxford, Connecticut); Joey Wong (Enfield, Connecticut)
ABSTRACT	A seal assembly includes a side ring and a cartridge. The side ring comprises an annular piece of solid material. The cartridge is affixed to the side ring and comprises a shoulder, a beam connected to and extending from the shoulder, a shoe attached to an end of the beam, and a rotary seal disposed on a bottom portion of the shoe.
FILED	Monday, September 25, 2017
APPL NO	15/714360
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/025 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/232 (20130101) F05D 2230/237 (20130101) F05D 2240/55 (20130101) Pistons; Cylinders; Sealings F16J 15/442 (20130101) F16J 15/4472 (20130101)
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10746049 — Gas turbine engine case including bearing compartment

US 10746049	Eastwood et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Jonathan Jeffery Eastwood (West Hartford, Connecticut); Adam Lee Hart (Stuart, Florida); Brian Levy (Sunny Isles Beach, Florida); Luis Miguel Ayalde (Weston, Florida); Brian Craig (Palm Beach Gardens, Florida); Jose R. Paulino (Saco, Maine); Esref Yaylagan (Plantation, Florida)
ABSTRACT	An example case for a gas turbine engine includes a bearing compartment, a radially outer ring, and a radially inner ring. The radially outer ring and radially inner ring are connected by a plurality of circumferentially spaced apart struts and define an annular flow path therebetween. The radially inner ring includes a first flange that extends radially outward from the bearing compartment. The first flange includes an undulation that extends axially away from the plurality of struts, and defines a load path between the bearing compartment and the radially outer ring.
FILED	Friday, March 30, 2018
APPL NO	15/941041
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/065 (20130101) F01D 25/16 (20130101) F01D 25/18 (20130101) F01D 25/24 (20130101) F01D 25/162 (20130101) Original (OR) Class F01D 25/183 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/50 (20130101)
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10746253 — Vibration damping device for an elongated member

US 10746253	Gmirya
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Sikorsky Aircraft Corporation (Stratford, Connecticut)
ASSIGNEE(S)	SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut)
INVENTOR(S)	Yuriy Gmirya (Woodbridge, Connecticut)
ABSTRACT	A vibration damping device is configured to reduce vibration that causes lateral flexing of an elongated member that extends along a centerline. The device includes a split sleeve co-extending with and disposed about the elongated member, and a spring that extends about the sleeve and exerts a force that biases the sleeve radially inward.
FILED	Tuesday, June 14, 2016
APPL NO	15/752813
ART UNIT	3679 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Aeroplanes; Helicopters B64C 27/001 (20130101) B64C 27/12 (20130101) Springs; Shock-absorbers; Means for Damping Vibration F16F 15/10 (20130101) F16F 15/12 (20130101) F16F 15/121 (20130101) F16F 15/123 (20130101) Original (OR) Class F16F 15/322 (20130101) Technical Subjects Covered by Former US Classification Y10T 74/2045 (20150115) Y10T 74/20456 (20150115)
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10746284 — Gearbox lubrication system for aircraft

US 10746284	Gmirya et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut)
ASSIGNEE(S)	SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut)
INVENTOR(S)	Yuriy Gmirya (Woodbridge, Connecticut); Thomas L. Sbabo (Hamden, Connecticut); John H. Meeson, Jr. (Trumbull, Connecticut); Rodger W. Bowman (Derby, Connecticut)
ABSTRACT	A gearbox for a rotary wing aircraft including a sump, a primary lubricant reservoir fluidically connected to the sump, one or more primary lubricant jets fluidically connected to the primary lubricant reservoir, an auxiliary lubricant reservoir fluidically connected to the sump, one or more auxiliary lubricant jets fluidically connected to the auxiliary lubricant reservoir, and at least one valve selectively fluidically connecting the sump and the primary lubricant reservoir based on a first lubricant pressure and the sump and the auxiliary lubricant reservoir based on a second lubricant pressure at the at least one valve.
FILED	Friday, February 19, 2016
APPL NO	15/566310
ART UNIT	3654 — Material and Article Handling
CURRENT CPC	Aeroplanes; Helicopters B64C 27/12 (20130101) Gearing F16H 57/04 (20130101) F16H 57/045 (20130101) F16H 57/0434 (20130101) F16H 57/0435 (20130101) F16H 57/0438 (20130101) F16H 57/0442 (20130101) F16H 57/0449 (20130101) Original (OR) Class F16H 57/0452 (20130101) F16H 57/0456 (20130101)
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10746326 — Additively manufactured tube array

US 10746326	Custer
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Aeronautical Systems Center (ASC)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	John Williams Custer (Cincinnati, Ohio)
ABSTRACT	A tube array and a method for additively manufacturing the tube array are provided. The tube array includes an outer wall formed by a plurality of curved segments and defining a primary flow passage. A plurality of divider walls are positioned within the primary flow passage to divide the primary flow passage into a plurality of tubes, each of the plurality of tubes being defined at least in part by one of the plurality of curved segments and two of the plurality of divider walls. Integrally formed inlet and outlet manifolds provide fluid communication between the tube array and an array inlet and outlet.
FILED	Monday, January 08, 2018
APPL NO	15/864053
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) B29C 65/02 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2023/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 6/08 (20130101) F02C 7/14 (20130101) F02C 7/18 (20130101) F02C 9/18 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/31 (20130101) F05D 2230/53 (20130101) F05D 2260/213 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 9/19 (20130101) Original (OR) Class
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10746476 — Underwater remote cooling apparatus

US 10746476	Jaccard et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	United States of America as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Gregory A. Jaccard (San Diego, California); Carl E. Lostrom (San Diego, California); Richard P. Johnson (San Diego, California)
ABSTRACT	A cooling apparatus for an underwater platform comprising: an evaporator block fabricated from a thermally conductive material and having a first surface that is shaped so as to releasably mate to an exterior surface contour of the underwater platform; a heat pipe having a working fluid sealed therein, wherein the heat pipe has a first end and a second end, and wherein the first end is in thermal communication with the evaporator block; a condenser block in thermal communication with the second end of the heat pipe; and a plurality of spring clamps mounted to the evaporator block and configured to bias the first surface of the evaporator block against the exterior surface of the underwater platform such that heat from the exterior surface of the underwater platform is transferred to the ambient water via the evaporator block, heat pipe, and condenser block.
FILED	Friday, January 11, 2019
APPL NO	16/246153
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/36 (20130101) Foundations; Excavations; Embankments; Underground or Underwater Structures E02D 29/06 (20130101) E02D 29/045 (20130101) E02D 2600/00 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/0275 (20130101) Original (OR) Class
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10746479 — Additively manufactured structures for thermal and/or mechanical systems, and methods for manufacturing the structures

US 10746479	Rush et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
INVENTOR(S)	Brian Magann Rush (Niskayuna, New York); Daniel Jason Erno (Clifton Park, New York); Thomas Adcock (Glenville, New York); Stefano Angelo Mario Lassini (Lowell, Michigan)
ABSTRACT	A cooling assembly includes walls extending around and defining an enclosed vapor chamber that holds a working fluid. An interior porous wick structure is disposed inside the chamber and lines interior surfaces of the walls. The wick structure includes pores that hold a liquid phase of the working fluid. The cooling assembly also includes an exterior porous wick structure lining exterior surfaces of the walls outside of the vapor chamber. The exterior wick structure includes pores that hold a liquid phase of a cooling fluid outside the vapor chamber. The interior wick structure holds the liquid working fluid until heat from an external heat source vaporizes the working fluid inside the vapor chamber. The exterior wick structure holds the liquid fluid outside the vapor chamber until heat from inside the vapor chamber vaporizes the liquid cooling fluid in the exterior wick structure for transferring heat away from the heat source.
FILED	Thursday, July 12, 2018
APPL NO	16/034050
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/342 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Cosmonautics; Vehicles or Equipment Therefor B64G 1/506 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/046 (20130101) Original (OR) Class F28D 2021/0021 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101)
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10746495 — Catapult launcher

US 10746495	Gieseke
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Newport, Rhode Island)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (, None)
INVENTOR(S)	Thomas J Gieseke (Warren, Rhode Island)
ABSTRACT	An impulse launcher is provided with a motor to store rotational kinetic energy in a flywheel. The stored kinetic energy is released using a planetary gear transmission that links the flywheel to a drive shaft. The kinetic energy is released when the planetary gear carrier is decelerated using a brake. The planetary gear carrier deceleration forces rotational acceleration of the drive shaft and deceleration of the flywheel. The drive shaft turns a primary drive sprocket and a secondary drive sprocket which pulls a studded drive belt which in turn drives a projectile located between the studded belt and a guide. The planetary gear system and belt drive allow rapid transfer of energy from the flywheel to a projectile.
FILED	Wednesday, August 28, 2019
APPL NO	16/553205
ART UNIT	3711 — Amusement and Education Devices
CURRENT CPC	Weapons for Projecting Missiles Without Use of Explosive or Combustible Propellant Charge; Weapons Not Otherwise Provided for F41B 4/00 (20130101) Original (OR) Class
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10746516 — Non-pyrotechnic diversionary device

US 10746516	Cayer
FUNDED BY	Department of Defense (DOD) Assistant Secretary of Defense for Special Operations/Low-Intensity Conflict (ASD SOLIC) Technical Support Working Group (TSWG)
APPLICANT(S)	Applied Research Associates, Inc. (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Richard Cayer (Littleton, Colorado)
ABSTRACT	The disclosed technology regards a reusable, non-pyrotechnic diversionary device having a housing assembly which receives and supports a pressure manifold, activation assembly, and a lighting assembly. The housing assembly includes a vessel, a main chassis, and a transparent lens. Positioned within the main chassis is a pressure manifold which supports a compressed gas source. A puncture pin is provided in the activation assembly, and aligned with the compressed gas source to facilitate puncture of the source. The disclosed technology further regards a reusable, non-pyrotechnic diversionary assembly having a housing assembly and a reloading tool. The reloading tool has an externally threaded inner body with an aperture at its distal end sized to receive the puncture pin, and an outer body sized and internally threaded to rotatably receive a portion of the inner body in its shaft, allowing the inner body to traverse through and from the shaft at its distal end. A threaded interface is provided on the outer body of the reloading tool to align with the first support structure of the pressure manifold. The inner body rotationally translates within the outer body to position the distal end of the inner body relative to the puncture pin and allow it to translate the puncture pin from an active position to a secured position.
FILED	Saturday, August 24, 2019
APPL NO	16/550196
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 4/04 (20130101) F42B 12/42 (20130101) Original (OR) Class F42B 27/00 (20130101) F42B 33/02 (20130101)
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10746520 — Thermomechanical active hazard mitigation capsule

US 10746520	Hall et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Department of the Navy (Indian Head, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Ian A. Hall (Rockville, Maryland); Edward A. Russo (Charlottesville, Virginia)
ABSTRACT	A thermomechanical safety device includes a body and a capsule valve mounted in the body. A volume of auto-ignition material is disposed in the capsule valve, which is moveable between a rest position and a firing position. A spring engages the capsule valve and the body, and biases the capsule valve towards the rest position. A temperature sensitive actuator engages the capsule valve and the body. The temperature sensitive actuator moves the capsule valve between the rest position and the firing position in response to a change in temperature. The temperature to cause the temperature sensitive actuator to move the capsule valve between the rest position and the firing position is less than the ignition temperature of the auto-ignition material.
FILED	Wednesday, October 24, 2018
APPL NO	16/350263
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/207 (20130101) Ammunition Fuzes; Arming or Safety Means Therefor F42C 15/36 (20130101) Original (OR) Class
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10746550 — Resonator fiber-optic gyro with quadrature error reducer

US 10746550	Strandjord et al.
FUNDED BY	Department of Defense (DOD) Office of the Secretary of Defense (OSD) DOD Ordnance Technology Consortium (DOTC)
APPLICANT(S)	Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	Honeywell International Inc. (Morris Plains, New Jersey)
INVENTOR(S)	Lee K. Strandjord (Tonka Bay, Minnesota); Glen A. Sanders (Scottsdale, Arizona); Marc Smiciklas (Phoenix, Arizona)
ABSTRACT	A resonance fiber-optic gyro (RFOG) with quadrature error reducer is provided. The RFOG with quadrature error reducer includes a laser assembly, a fiber resonator assembly, a resonance tracking loop and a quadrature error reducer circuit. The resonance tracking loop, coupled to an output of the finder resonator assembly, is used to generate a resonance frequency signal that is coupled to an OPLL mixer in one of a CCW OPLL or the CW OPLL of the laser assembly. The quadrature error reducer circuit includes an amplitude control loop and a second harmonic phase control loop. The amplitude control loop is used to generate a common modulation signal. An output of the amplitude control loop is coupled to a common phase modulator in the laser assembly. The second harmonic phase control loop is used to selectively adjust a phase of a second harmonic modulation signal in the amplitude control loop at startup.
FILED	Wednesday, August 01, 2018
APPL NO	16/052024
ART UNIT	2886 — Optics
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/721 (20130101) G01C 19/727 (20130101) Original (OR) Class Demodulation or Transference of Modulation From One Carrier to Another H03D 7/165 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/3863 (20130101)
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10746713 — Contaminant cleaning systems and related methods using one or more reactive substances, reaction byproduct measurements, and differential pressure or vacuum transfer of the reactive substances and reaction byproducts

US 10746713	Graupmann et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Surface Warfare Center (NSWC)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Crane, Indiana)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Mary M. Graupmann (Eastvale, California); Christopher H. Clark (Riverside, California); Michael L. Bishop (Moreno Valley, California)
ABSTRACT	Contaminant cleaning systems and related methods are provided. Exemplary embodiments include a reactive substance generator to produce or transfer reactive substance(s) that react with contaminant(s) on an item into a cleaning chamber. An analysis section can be attached to the cleaning chamber to perform gas analysis on gas samples brought into the analysis chamber that measure reaction byproducts from the reactive substance(s) interaction with the contaminants. An exemplary valve system can selectively couple the reactive substance generator, the analysis section, and the cleaning chamber. An exemplary pumping system, in combination with the valve system, can selectively generate differential pressure/vacuum levels between the reactive substance generator vs cleaning chamber as well as between the cleaning chamber and analysis section. For example, the analysis chamber can be configured to have a higher vacuum than the cleaning chamber to facilitate passage of gas test samples into the analysis chamber.
FILED	Saturday, August 25, 2018
APPL NO	16/112680
ART UNIT	1718 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Cleaning in General; Prevention of Fouling in General B08B 9/027 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0009 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 37/32862 (20130101) H01J 37/32981 (20130101)
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10746785 — Dynamic predictor of semiconductor lifetime limits

US 10746785	Cher et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Chen-Yong Cher (Port Chester, New York); Keith A. Jenkins (Sleepy Hollow, New York); Barry P. Linder (Hastings-on-Hudson, New York)
ABSTRACT	A method and circuit of monitoring an effective age of a target circuit are provided. A standby mode is activated in the target circuit. A standby current of a first number of circuit blocks of the target circuit is measured. The measured standby current of the first number of circuit blocks is compared to a first baseline standby current of the first number of circuit blocks. Upon determining that the measured standby current of the first number of circuit blocks is below a first predetermined factor of a baseline standby current of the first number of circuit blocks, the first number of circuit blocks is identified to have a bias temperature instability (BTI) degradation concern.
FILED	Friday, August 05, 2016
APPL NO	15/230067
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2837 (20130101) G01R 31/2849 (20130101) Original (OR) Class
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10746867 — Determining surface characteristics

US 10746867	Stanley et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Byron McCall Stanley (Newton, Massachusetts); Matthew Tyler Cornick (San Diego, California)
ABSTRACT	A method for determining surface characteristics is disclosed. The method may include transmitting a surface penetrating radar (SPR) signal towards a surface from a SPR system. The method may also include receiving a response signal at the SPR system. The response signal may include, at least in part, a reflection of the SPR signal from a surface region associated with the surface. The method may further include measuring at least one of an intensity and a phase of the response signal. The method my additionally include determining, based at least in part on the at least one of the intensity and the phase of the response signal, a surface characteristic of the surface.
FILED	Monday, January 29, 2018
APPL NO	15/882889
ART UNIT	3668 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 40/06 (20130101) B60W 2552/00 (20200201) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/26 (20130101) G01C 21/3602 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/411 (20130101) G01S 13/87 (20130101) G01S 13/89 (20130101) G01S 13/862 (20130101) G01S 13/865 (20130101) G01S 13/867 (20130101) G01S 13/872 (20130101) G01S 13/885 (20130101) Original (OR) Class G01S 13/951 (20130101) G01S 2013/9327 (20200101)
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10746935 — Fiber-to-waveguide coupling with high alignment tolerance

US 10746935	Lipson et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Michal Lipson (New York, New York); You-Chia Chang (New York, New York); Oscar Adrian Jimenez Gordillo (New York, New York); Mohammad Amin Tadayon (New York, New York); Brian Stern (New York, New York)
ABSTRACT	An optical coupling apparatus comprising a substrate having a trench formed therein, the trench having a width measured between two opposing walls that define a portion of the trench; and a waveguide disposed on or in the substrate, the waveguide having a width that tapers along an axis of light propagation.
FILED	Tuesday, January 30, 2018
APPL NO	15/883367
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/305 (20130101) Original (OR) Class G02B 6/1228 (20130101)
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10747711 — Dynamic hybridized positional notation instruction set computer architecture to enhance security

US 10747711	Telesca, Jr. et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (Flagstaff, Arizona); GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE AIRFORCE (Rome, New York)
INVENTOR(S)	Donald A. Telesca, Jr. (Whitesboro, New York); Bertrand F Cambou (Flagstaff, Arizona); Paul G Flikkema (Flagstaff, Arizona)
ABSTRACT	Disclosed herein is a computing system with the capability to execute instructions in different positional notation values. The definition of a positional notation value is given by the general formula that represent a base 10 numeral in any positional notation in the following manner: . . . d₃r³+d₂r²+d₁r¹+d₀r⁰, where d is a coefficient, r is the base of the positional number system (i.e. r=2 for binary, or r=3 for ternary), and the exponent is the position of the digit. The computing may provide a configuration which hybridizes the instructions of multiple positional notation values in variable ratios. The computing system may dynamically switch between the multiple hybridized instructions sets. Embodiments may be applied to provide security benefits.
FILED	Tuesday, March 19, 2019
APPL NO	16/358509
ART UNIT	2192 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 8/41 (20130101) G06F 9/4411 (20130101) G06F 9/45545 (20130101) G06F 15/7871 (20130101) Original (OR) Class G06F 21/52 (20130101) G06F 21/6227 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0618 (20130101) H04L 9/0643 (20130101) H04L 9/0822 (20130101) H04L 9/3073 (20130101)
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10747880 — System and method for identifying and comparing code by semantic abstractions

US 10747880	Lakhotia
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Air Force Research Laboratory (AFRL) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	University of Louisiana at Lafayette (Lafayette, Louisiana)
ASSIGNEE(S)	University of Louisiana at Lafayette (Lafayette, Louisiana)
INVENTOR(S)	Arun Lakhotia (Lafayette, Louisiana)
ABSTRACT	Certain embodiments of the present invention are configured to facilitate analyzing computer code more efficiently. For example, by conducting a first level abstraction (e.g., symbolic interpretation and algebraic simplification) and a second level abstraction (e.g., generalization) of the computer code, the analysis may more accurately account for variations in the code that may occur as a result of register renaming, instruction reordering, choice of instructions, etc. while minimizing the cost of computations required to perform the analysis.
FILED	Monday, December 30, 2013
APPL NO	14/143823
ART UNIT	2493 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/563 (20130101) Original (OR) Class
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10747936 — System, method, and computer program product for genetic routing in an electronic circuit design

US 10747936	Luo et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Cadence Design Systems, Inc. (San Jose, California)
ASSIGNEE(S)	Cadence Design Systems, Inc. (San Jose, California)
INVENTOR(S)	Hua Luo (Pittsburgh, Pennsylvania); Regis R. Colwell (Gibsonia, Pennsylvania); Wangyang Zhang (Allison Park, Pennsylvania)
ABSTRACT	The present disclosure relates to a computer-implemented method for electronic design is provided. Embodiments may include receiving, using at least one processor, an electronic design having one or more unoptimized nets. Embodiments may further include applying a genetic algorithm to the electronic design, wherein the genetic algorithm includes a two stage routing analysis, wherein a first stage analysis is an intra-row routing analysis and a second stage is an inter-row routing analysis. Embodiments may also include generating an optimized routing of the one or more nets and displaying the optimized routing at a graphical user interface.
FILED	Wednesday, July 31, 2019
APPL NO	16/527412
ART UNIT	2851 — Printing/Measuring and Testing
CURRENT CPC	Electric Digital Data Processing G06F 30/394 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/126 (20130101)
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10748352 — Systems and methods for remotely triggered data acquisition

US 10748352	Bandy et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut)
ASSIGNEE(S)	SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut)
INVENTOR(S)	Isaac Bandy (Eden Prairie, Minnesota); Seth W. Mason (Orange, Connecticut)
ABSTRACT	A method of data acquisition for health management of systems is provided. The method includes receiving, at a remote node, analog data from one or more sensors configured to monitor a health characteristic of a system, converting, at the remote node, the analog data into digital data, time stamping the digital data with the remote node, recording the digital data in a memory of the remote node, wherein the memory is a ring buffer, transmitting, from the remote node to a central device, requested digital data upon receiving a request related to a triggering event, and synchronizing the transmitted data at the central device based on the time stamp of the requested digital data to generate synchronized data.
FILED	Friday, January 15, 2016
APPL NO	15/557881
ART UNIT	3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Electric Digital Data Processing G06F 17/40 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/008 (20130101) Original (OR) Class G07C 5/085 (20130101) G07C 5/0808 (20130101) Transmission Systems for Measured Values, Control or Similar Signals G08C 25/04 (20130101) Selecting H04Q 9/04 (20130101)
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10748682 — Surge arrester system and circuit breaker system

US 10748682	Tschida et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	ABB Schweiz AG (Baden, Switzerland)
ASSIGNEE(S)	ABB Schweiz AG (Baden, Switzerland)
INVENTOR(S)	Colin Tschida (Durham, North Carolina); Pietro Cairoli (Raleigh, North Carolina); Francesco Agostini (Zürich, Switzerland); Daniele Torresin (Birmenstorf, Switzerland); Davide Leoni (Trescore Balneario, Italy); Luca Raciti (Bergamo, Italy); Zhiguo Pan (Cary, North Carolina)
ABSTRACT	A surge arrester system includes a surge arrester, and an active cooling system having a cooling interface in contact with the surge arrester and operative to transfer heat from the surge arrester. The active cooling system includes a forced convection apparatus operative to provide forced convection cooling. A circuit breaker system includes a power semiconductor switch and an active cooling system constructed to cool the power semiconductor switch. The active cooling system includes a forced convection apparatus configured to provide forced convection cooling. The power semiconductor switch is in contact with the active cooling system. A surge arrester is disposed adjacent to and in contact with the active cooling system. The active cooling system includes a cooling interface constructed for contact with the surge arrester and operative to provide cooling to the surge arrester. The power semiconductor switch and the surge arrester dissipate power alternatively.
FILED	Wednesday, May 31, 2017
APPL NO	15/610420
ART UNIT	2848 — Electrical Circuits and Systems
CURRENT CPC	Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 17/54 (20130101) Resistors H01C 1/02 (20130101) H01C 7/12 (20130101) Original (OR) Class Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 9/52 (20130101) H01H 9/54 (20130101) H01H 2009/523 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/46 (20130101) Emergency Protective Circuit Arrangements H02H 9/041 (20130101) Pulse Technique H03K 17/0828 (20130101)
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10749056 — Method for making ferroelectric material thin films

US 10749056	Spanier et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	Drexel University (Philadelphia, Pennsylvania); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	Drexel University (Philadelphia, Pennsylvania)
INVENTOR(S)	Jonathan E. Spanier (Bala Cynwyd, Pennsylvania); Peter K. Davies (Newtown, Pennsylvania); Andrew M. Rappe (Penn Valley, Pennsylvania); Liyan Wu (Philadelphia, Pennsylvania); Andrei R. Akbasheu (Mountain View, California); Ilya Grinberg (Fairlawn, New Jersey)
ABSTRACT	A method of growing a FE material thin film using physical vapor deposition by pulsed laser deposition or RF sputtering is disclosed. The method involves creating a target to be used for the pulsed laser deposition in order to create a KBNNO thin film. The resultant KBNNO thin film is able to be used in photovoltaic cells.
FILED	Friday, February 10, 2017
APPL NO	15/430135
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/495 (20130101) C04B 35/6261 (20130101) C04B 35/6262 (20130101) C04B 35/62675 (20130101) C04B 35/62685 (20130101) C04B 2235/443 (20130101) C04B 2235/604 (20130101) C04B 2235/761 (20130101) C04B 2235/768 (20130101) C04B 2235/3201 (20130101) C04B 2235/3215 (20130101) C04B 2235/3251 (20130101) C04B 2235/3255 (20130101) C04B 2235/3279 (20130101) C04B 2235/6587 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/088 (20130101) C23C 14/3414 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/032 (20130101) Original (OR) Class
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10749062 — Hybrid tandem solar cells with improved tunnel junction structures

US 10749062	Ma et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	Zhenqiang Ma (Middleton, Wisconsin); Kanglin Xiong (Madison, Wisconsin); Hongyi Mi (Madison, Wisconsin); Tzu-Hsuan Chang (Madison, Wisconsin); Shaoqin Gong (Middleton, Wisconsin); Jung-Hun Seo (East Amherst, New York)
ABSTRACT	Tandem solar cells comprising two or more solar cells connected in a solar cell stack via pn diode tunnel junctions and methods for fabricating the tandem solar cells using epitaxial lift off and transfer printing are provided. The tandem solar cells have improved tunnel junction structures comprising a current tunneling layer integrated between the p and n layers of the pn diode tunnel junction that connects the solar cells.
FILED	Tuesday, January 09, 2018
APPL NO	15/865662
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0693 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/544 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/521 (20151101)
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10749097 — Current crowding in three-terminal superconducting devices and related methods

US 10749097	McCaughan et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Adam N. McCaughan (Cambridge, Massachusetts); Karl K. Berggren (Arlington, Massachusetts); Qingyuan Zhao (Malden, Massachusetts)
ABSTRACT	An active three-terminal superconducting device having an intersection region at which a hot spot may be controllably formed is described. The intersection region may exhibit current crowding in response to imbalances in current densities applied to channels connected to intersection region. The current crowding may form a hot spot, in which the superconducting device may exhibit a measurable resistance. In some cases, a three-terminal superconducting device may be configured to sense an amount of superconducting current flowing in a channel or loop without having to perturb the superconducting state or amount of current flowing in the channel. A three-terminal superconducting device may be used to read out a number of fluxons stored in a superconducting memory element.
FILED	Friday, April 01, 2016
APPL NO	15/563158
ART UNIT	2816 — Semiconductors/Memory
CURRENT CPC	Static Stores G11C 11/44 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/10 (20130101) Original (OR) Class H01L 39/145 (20130101)
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10749270 — Polarization rotating phased array element

US 10749270	Behdad et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Nader Behdad (Oregon, Wisconsin); Zhe Yang (Madison, Wisconsin); John H. Booske (McFarland, Wisconsin); Hung Thanh Luyen (Madison, Wisconsin)
ABSTRACT	A phase shifter includes a first dielectric layer, a switch mounted to the first dielectric layer, a conductive layer mounted to the first dielectric layer, a second dielectric layer mounted to the conductive layer, a conducting pattern layer mounted to the second dielectric layer, and a plurality of vias. The switch is switchable between a first conducting position and a second conducting position. Each via is connected between a first or a second throw arm of the switch and a conductor of the conducting pattern layer. When an electromagnetic wave incident on the phase shifter is reflected, an electric polarization of the reflected electromagnetic wave is rotated by ±90 degrees compared to an electric polarization of the incident electromagnetic wave based on a conducting position of the switch. The phase shifter can be used as one-bit spatial phase shifter to provide either 0° or 180° phase shift over wide bandwidths.
FILED	Friday, May 11, 2018
APPL NO	15/977130
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 3/36 (20130101) H01Q 15/14 (20130101) H01Q 21/0006 (20130101) H01Q 21/22 (20130101) Original (OR) Class
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10749434 — Power converter with capacitive energy transfer and fast dynamic response

US 10749434	Giuliano et al.
FUNDED BY	Department of Defense (DOD) Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	David M. Giuliano (Cambridge, Massachusetts); David J. Perreault (Cambridge, Massachusetts); Robert C. N. Pilawa-Podgurski (Cambridge, Massachusetts)
ABSTRACT	A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices.
FILED	Wednesday, November 27, 2019
APPL NO	16/697318
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/07 (20130101) H02M 3/155 (20130101) H02M 3/158 (20130101) Original (OR) Class H02M 2001/007 (20130101)
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10749469 — Transformer based shielded oscillator

US 10749469	Anand et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Tejasvi Anand (Corvallis, Oregon); Mark A. Ferriss (Tarrytown, New York); Bodhisatwa Sadhu (Fishkill, New York); Alberto Valdes Garcia (Chappaqua, New York)
ABSTRACT	An oscillator includes a first output node and a second output node. There is a tank circuit coupled between the first output node and the second output node. There is a first transistor having a first node, a second node coupled to a current source, and a control node coupled to the second output node. There is a second transistor having a first node, a second node coupled to the current source, and a control node coupled to the first output node. There is a first inductor coupled in series between the first node of the first transistor and the first output node. There is a second inductor coupled in series between the first node of the second transistor and the second output node.
FILED	Saturday, September 22, 2018
APPL NO	16/138989
ART UNIT	2849 — Material and Article Handling
CURRENT CPC	Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 5/08 (20130101) H03B 5/1212 (20130101) H03B 5/1215 (20130101) H03B 5/1228 (20130101) H03B 5/1231 (20130101) Original (OR) Class H03B 5/1296 (20130101) H03B 5/1852 (20130101) H03B 2200/009 (20130101)
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10749557 — Adaptive spur processing

US 10749557	Griffin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Department of the Navy (DON)
APPLICANT(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Gregory T. Griffin (Hollis, New Hampshire); Richard B. Elder, Jr. (Bedford, New Hampshire)
ABSTRACT	A system and method for adaptive spurious signal (spur) processing at a broadband RF receiver. Spur processing addresses the detection of spurs generated by the receiver when high level RF signals are present at its input. The spurs can lead to undesired false detections. Based on signal parameters of the received RF signal, the system detects a strong enough real signal that would cause a spur and prevent generation of false reports. The adaptive spur mitigation scheme uses multiple detection and report thresholds to enable false report rejection with an improved high probability of rejecting false detections, while minimizing the adverse effects on multi-tone dynamic range. The necessary detection and report thresholds are generated based on a system level behavioral model that predicts the performance of several different types of spurs as a function of signal parameters. The thresholds are tuned to match the behavior of the dominant spur.
FILED	Friday, July 12, 2019
APPL NO	16/510244
ART UNIT	2631 — Digital Communications
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Transmission H04B 1/18 (20130101) H04B 1/109 (20130101) Original (OR) Class H04B 17/3913 (20150115)
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10749900 — Deploying session initiation protocol application network security

US 10749900	Raj
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S)	The MITRE Corporation (McLean, Virginia)
INVENTOR(S)	Alex E. Raj (McLean, Virginia)
ABSTRACT	Described are systems, methods, and computer-program product embodiments for providing Session Initiation Protocol (SIP) network security. In some embodiments, a SIP processing system includes a SIP device configured to establish and control a SIP communication session between SIP user agents. In some embodiments, the SIP processing system includes a SIP device that establishes a recording session with a first server to receive SIP messages relayed in the SIP communication session. The first server decodes the SIP messages based on metadata in the SIP messages to extract multimedia content. Then, the first server opens a socket connection to establish a security session with a security system configured to determine whether the portion is associated with a detected threat and transmits a portion of the decoded multimedia to the security system. Based on a threat status generated by and received from the security system, the first server controls the SIP communication session.
FILED	Friday, September 28, 2018
APPL NO	16/146691
ART UNIT	2497 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 63/166 (20130101) H04L 63/168 (20130101) Original (OR) Class H04L 65/1006 (20130101) H04L 65/1069 (20130101) H04L 69/16 (20130101)
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10750155 — Mapping and tracking system with features in three-dimensional space

US 10750155	Karvounis
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Defense Contract Management Agency (DCMA) Department of the Army (DOA)
APPLICANT(S)	TRX SYSTEMS, INC. (Greenbelt, Maryland)
ASSIGNEE(S)	TRX SYSTEMS, INC. (Greenbelt, Maryland)
INVENTOR(S)	John George Karvounis (Bowie, Maryland)
ABSTRACT	LK-SURF, Robust Kalman Filter, HAR-SLAM, and Landmark Promotion SLAM methods are disclosed. LK-SURF is an image processing technique that combines Lucas-Kanade feature tracking with Speeded-Up Robust Features to perform spatial and temporal tracking using stereo images to produce 3D features can be tracked and identified. The Robust Kalman Filter is an extension of the Kalman Filter algorithm that improves the ability to remove erroneous observations using Principal Component Analysis and the X84 outlier rejection rule. Hierarchical Active Ripple SLAM is a new SLAM architecture that breaks the traditional state space of SLAM into a chain of smaller state spaces, allowing multiple tracked objects, multiple sensors, and multiple updates to occur in linear time with linear storage with respect to the number of tracked objects, landmarks, and estimated object locations. In Landmark Promotion SLAM, only reliable mapped landmarks are promoted through various layers of SLAM to generate larger maps.
FILED	Thursday, June 14, 2018
APPL NO	16/009115
ART UNIT	2485 — Recording and Compression
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00201 (20130101) G06K 9/00664 (20130101) G06K 9/4671 (20130101) G06K 9/6248 (20130101) G06K 2209/29 (20130101) Image Data Processing or Generation, in General G06T 7/85 (20170101) G06T 7/246 (20170101) G06T 7/277 (20170101) G06T 2200/28 (20130101) G06T 2207/10021 (20130101) G06T 2207/20021 (20130101) G06T 2207/20088 (20130101) Pictorial Communication, e.g Television H04N 5/2224 (20130101) H04N 13/122 (20180501) H04N 13/239 (20180501) Original (OR) Class H04N 13/246 (20180501) H04N 13/282 (20180501) H04N 2013/0092 (20130101)
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10750627 — High voltage power module

US 10750627	Cole et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Cree Fayetteville, Inc. (Fayetteville, Arkansas)
ASSIGNEE(S)	Cree Fayetteville, Inc. (Fayetteville, Arkansas)
INVENTOR(S)	Zachary Cole (Summers, Arkansas); Brandon Passmore (Fayetteville, Arkansas)
ABSTRACT	A power module includes a number of sub-modules connected via removable jumpers. The removable jumpers allow the connections between one or more power semiconductor die in the sub-modules to be reconfigured, such that when the removable jumpers are provided, the power module has a first function, and when the removable jumpers are removed, the power module has a second function. The removable jumpers may also allow for independent testing of the sub-modules. The power module may also include a multi-layer printed circuit board (PCB), which is used to connect one or more contacts of the power semiconductor die. The multi-layer PCB reduces stray inductance between the contacts and therefore improves the performance of the power module.
FILED	Thursday, March 21, 2019
APPL NO	16/360333
ART UNIT	2847 — Electrical Circuits and Systems
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/4093 (20130101) H01L 23/5382 (20130101) H01L 25/072 (20130101) H01L 25/115 (20130101) H01L 25/162 (20130101) H01L 29/78 (20130101) H01L 29/1608 (20130101) H01L 2224/49111 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/088 (20130101) H02M 7/003 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0298 (20130101) H05K 5/0065 (20130101) Original (OR) Class H05K 5/0069 (20130101) H05K 2201/10166 (20130101)
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Department of Energy (DOE)

10744488 — Ozone-activated nanoporous gold and methods of its use

US 10744488	Friend et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA Office of Science (DOE-SC)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts); Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Cynthia M. Friend (Belmont, Massachusetts); Robert J. Madix (Belmont, Massachusetts); Branko Zugic (Somerville, Massachusetts); Lucun Wang (Malden, Massachusetts); Michelle L. Personick (Cambridge, Massachusetts); Juergen Biener (San Leandro, California); Monika Margarete Biener (San Leandro, California)
ABSTRACT	The invention relates to nanoporous gold nanoparticle catalysts formed by exposure of nanoporous gold to ozone at elevated temperatures, as well as methods for production of esters and other compounds.
FILED	Friday, January 20, 2017
APPL NO	16/070943
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/52 (20130101) Original (OR) Class B01J 35/002 (20130101) B01J 35/10 (20130101) B01J 35/0013 (20130101) B01J 35/023 (20130101) B01J 35/026 (20130101) B01J 35/1009 (20130101) B01J 35/1061 (20130101) B01J 35/1066 (20130101) B01J 37/06 (20130101) B01J 37/14 (20130101) B01J 37/16 (20130101) B01J 37/0018 (20130101) B01J 37/0215 (20130101) Acyclic or Carbocyclic Compounds C07C 45/29 (20130101) C07C 45/29 (20130101) C07C 47/04 (20130101) C07C 67/39 (20130101) C07C 67/39 (20130101) C07C 67/40 (20130101) C07C 67/40 (20130101) C07C 67/40 (20130101) C07C 69/06 (20130101) C07C 69/54 (20130101) C07C 69/54 (20130101)
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10744695 — Polymer composites for fused filament fabrication and methods of making the same

US 10744695	Erikson et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
INVENTOR(S)	Rebecca L. Erikson (Richland, Washington); Josef F. Christ (Pasco, Washington); Zachary C. Kennedy (Richland, Washington); Kent A. Evans (San Jose, California); Christopher A. Barrett (Richland, Washington); Satish K. Nune (Richland, Washington)
ABSTRACT	Disclosed are compositions of a fused filament fabrication (FFF) composite filament having embedded functional materials in a thermoplastic matrix. Methods of making the composite filaments are also disclosed. In one example, a FFF composite filament incorporates a MOF, in an amount greater than 10% by mass, dispersed in a matrix polymer. One example of a method of synthesizing FFF composite filaments involves mixing a suspension that has a MOF with a matrix polymer solution to yield a polymer-MOF mixture. The mixture is cast and dried into a solid composite material, which is formed a FFF composite filament having the MOF in an amount greater than 10% by mass.
FILED	Thursday, January 18, 2018
APPL NO	15/874062
ART UNIT	1744 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/05 (20190201) Original (OR) Class B29C 64/118 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2067/046 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/26 (20130101) C08J 9/0066 (20130101) C08J 2375/04 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/0091 (20130101) C08K 5/0091 (20130101) C08K 5/3445 (20130101) Compositions of Macromolecular Compounds C08L 67/04 (20130101)
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10745330 — Method of converting ethanol to higher alcohols

US 10745330	Ramasamy et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
INVENTOR(S)	Karthikeyan K. Ramasamy (West Richland, Washington); Mond F. Guo (Richland, Washington); Michel J. Gray (Kennewick, Washington); Senthil Subramaniam (Richland, Washington)
ABSTRACT	A method and catalyst for forming higher alcohols from lower alcohol feedstocks. In one application a highly selective and stable copper pseudo-single-atom supported on MgO—Al₂O₃catalyst is provided which provides ethanol condensation to higher alcohols at ˜50% yields and ˜85% selectivity is demonstrated with stable catalyst lifetime over 500 hours in a continuous flow system. In some applications a Guerbet condensation process is further utilized to yield a higher alcohol at a selectivity of near ˜90%.
FILED	Thursday, July 26, 2018
APPL NO	16/046395
ART UNIT	1699 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 29/32 (20130101) C07C 29/32 (20130101) C07C 29/32 (20130101) C07C 29/34 (20130101) Original (OR) Class C07C 29/34 (20130101) C07C 29/34 (20130101) C07C 31/12 (20130101) C07C 31/12 (20130101) C07C 31/125 (20130101) C07C 31/125 (20130101)
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10745340 — Oxidation of alkanes to alcohols

US 10745340	Periana et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S)	The Scripps Research Institute (La Jolla, California)
INVENTOR(S)	Roy A Periana (Jupiter, Florida); Brian G Hashiguchi (Palm Beach Gardens, Florida); Michael M Konnick (Palm Beach Gardens, Florida); Steven M Bischof (Jupiter, Florida)
ABSTRACT	The invention provides processes and materials for the efficient and cost-effective functionalization of alkanes, such as methane from natural gas, to provide esters, alcohols, and other compounds. The method can be used to produce liquid fuels such as methanol from a natural gas methane-containing feedstock. The soft oxidizing electrophile, a compound of a main group, post-transitional element such as Tl, Pb, Bi, and I, that reacts to activate the alkane C—H bond can be regenerated using inexpensive regenerants such as hydrogen peroxide, oxygen, halogens, nitric acid, etc. Main group compounds useful for carrying out this reaction includes haloacetate salts of metals having a pair of available oxidation states, such as Tl, Pb, Bi, and I. The inventors herein believe that a unifying feature of many of the MXn electrophiles useful in carrying out this reaction, such as Tl, Pb, and Bi species, is their isoelectronic configuration in the alkane-reactive oxidation state; the electrons having the configuration [Xe]4f145d10, with an empty 6s orbital. However, the iodine reagents have a different electronic configuration.
FILED	Tuesday, February 25, 2014
APPL NO	14/770039
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 67/035 (20130101) Original (OR) Class C07C 67/035 (20130101) C07C 69/63 (20130101)
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10745641 — Low friction wear resistant graphene films

US 10745641	Sumant et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	Anirudha V. Sumant (Plainfield, Illinois); Ali Erdemir (Naperville, Illinois); Diana Berman (Darien, Illinois)
ABSTRACT	A low friction wear surface with a coefficient of friction in the superlubric regime including graphene and nanoparticles on the wear surface is provided, and methods of producing the low friction wear surface are also provided. A long lifetime wear-resistant surface including graphene exposed to hydrogen is provided, including methods of increasing the lifetime of graphene containing wear surfaces by providing hydrogen to the wear surface.
FILED	Thursday, February 09, 2017
APPL NO	15/428387
ART UNIT	1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 1/02 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 111/02 (20130101) C10M 171/06 (20130101) Original (OR) Class C10M 177/00 (20130101) C10M 2201/05 (20130101) C10M 2201/10 (20130101) C10M 2201/041 (20130101) C10M 2201/053 (20130101) C10M 2201/061 (20130101) C10M 2201/0413 (20130101) C10M 2201/0663 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2220/082 (20130101) C10N 2230/06 (20130101) C10N 2240/02 (20130101) C10N 2240/30 (20130101) C10N 2240/58 (20130101) C10N 2240/202 (20130101) C10N 2240/204 (20130101) C10N 2240/404 (20130101) C10N 2250/121 (20130101) C10N 2270/00 (20130101)
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10745693 — Methods of designing programmable inducible promoters

US 10745693	Raman et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	Srivatsan Raman (Middleton, Wisconsin); Aseem Zoe Ansari (Madison, Wisconsin); Xiangyang Liu (Madison, Wisconsin); Jose Arcadio Rodriguez-Martinez (Dorado, Puerto Rico)
ABSTRACT	Described herein is a method for identifying synthetic inducible promoters that have specified induction and/or repression for DNA binding proteins such as an allosteric transcription factor and an inducer molecule. The method includes an in vitro selection from an unselected polynucleotide library comprising a plurality of random degeneracies, and an in vivo selection to produce an induced promoter library. Produced is an induction table, which allows the selection of a promoter with specific induction and/or repression properties. Also included are biosensors containing the synthetic inducible promoters.
FILED	Wednesday, April 04, 2018
APPL NO	15/945050
ART UNIT	1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1051 (20130101) C12N 15/1051 (20130101) C12N 15/1058 (20130101) C12N 15/1065 (20130101) Original (OR) Class C12N 15/1086 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2537/159 (20130101)
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10745707 — Digestibility of plant biomass

US 10745707	Brandizzi et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S)	Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S)	Federica Brandizzi (Okemos, Michigan); Sang Jin Kim (Okemos, Michigan); Starla Zemelis-Durfee (Dewitt, Michigan)
ABSTRACT	Plants described herein have increased biomass and are more readily digested into fermentable sugars when the plants express increased levels of one or more types of CGR2 and/or CGR3 enzymes.
FILED	Monday, December 17, 2018
APPL NO	16/221838
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/18 (20130101) C12N 15/52 (20130101) C12N 15/113 (20130101) C12N 15/8223 (20130101) Original (OR) Class C12N 15/8243 (20130101) C12N 15/8245 (20130101) C12N 15/8246 (20130101) C12N 15/8247 (20130101) Enzymes C12Y 301/01011 (20130101)
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10745708 — Transgenic plants with engineered redox sensitive modulation of photosynthetic antenna complex pigments and methods for making the same

US 10745708	Sayre
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Basic Energy Sciences (BES) Energy Frontier Research Centers (EFRC) Center for Advanced Biofuel Systems (CABS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Emerging Frontiers (EF)
APPLICANT(S)	NMC, INC. (Los Alamos, New Mexico)
ASSIGNEE(S)	NMC, INC. (Los Alamos, New Mexico)
INVENTOR(S)	Richard Thomas Sayre (Los Alamos, New Mexico)
ABSTRACT	Embodiments of the present invention provide for a transgenic plan, methods of making and DNA constructs for use in the transgenic plant which transgenic plant is capable of modulating its photosynthetic antenna complex composition in response to increases or decreases in light intensity by modulation of the ratio of chlorophyll a to chlorophyll b such that there is an increase in the Chl a/b ratio at high light intensity and a decrease in the Chl a/b ratio at low light intensity versus wild-type plants grown in the same conditions.
FILED	Friday, May 12, 2017
APPL NO	15/594274
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0073 (20130101) C12N 15/825 (20130101) C12N 15/8222 (20130101) C12N 15/8237 (20130101) Original (OR) Class C12N 15/8245 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) Enzymes C12Y 114/13122 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101)
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10745709 — Grasses with enhanced starch content

US 10745709	McKinley et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	The Texas A and M University System (College Station, Texas)
ASSIGNEE(S)	The Texas A and M University System (College Station, Texas)
INVENTOR(S)	Brian McKinley (College Station, Texas); John E. Mullet (College Station, Texas)
ABSTRACT	Methods and compositions for the production of monocot plants with increased starch content in stems are provided. In accordance with the invention, novel promoters and regulatory elements with specific temporal and spatial expression patterns are disclosed together with methods for the production of plants having desirable stem composition at harvest.
FILED	Wednesday, September 14, 2016
APPL NO	15/759171
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/10 (20130101) C12N 15/87 (20130101) C12N 15/8218 (20130101) C12N 15/8226 (20130101) C12N 15/8245 (20130101) Original (OR) Class
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10745719 — Enzymes and methods for dealkylation of substrates

US 10745719	Johnson et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S)	Christopher W. Johnson (Denver, Colorado); Gregg T. Beckham (Denver, Colorado)
ABSTRACT	Disclosed herein are enzymes and organisms useful for the dealkylation of products derived from lignin depolymerization, including the conversion of guaiacol or guaethol to catechol or the conversion of anisole to phenol. Methods of converting guaiacol or guaethol to catechol or anisole to phenol using enzymes or organisms expressing the same are also disclosed.
FILED	Thursday, December 06, 2018
APPL NO	16/211816
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/0095 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/22 (20130101) Original (OR) Class Enzymes C12Y 114/00 (20130101) C12Y 118/01002 (20130101)
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10745726 — Methods for mitigating the inhibitory effects of lignin and soluble phenolics for enzymatic conversion of cellulose

US 10745726	Ladisch et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO Office of Science (DOE-SC)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Michael Ralph Ladisch (West Lafayette, Indiana); Young Mi Kim (Woodbury, Minnesota)
ABSTRACT	Disclosed herein are methods for improving ethanol production from biomass sources by blocking cellulose from binding to lignin.
FILED	Friday, December 18, 2015
APPL NO	15/541531
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) C12P 19/14 (20130101) Original (OR) Class C12P 2201/00 (20130101) Saccharides Obtained From Natural Sources or by Hydrolysis of Naturally Occurring Disaccharides, Oligosaccharides or Polysaccharides C13K 1/02 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/16 (20130101)
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10745781 — Alumina-forming, high temperature creep resistant Ni-based alloys

US 10745781	Muralidharan et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Govindarajan Muralidharan (Knoxville, Tennessee); Bruce A. Pint (Knoxville, Tennessee)
ABSTRACT	An alumina-forming, high temperature creep resistant alloy is composed essentially of, in terms of weight percent: up to 10 Fe, 3.3 to 4.6 Al, 6 to 22 Cr, 0.68 to 0.74 Mn, 5.2 to 6.6 Mo, 0.4 to 1.2 Ti, up to 0.1 Hf, 0.005 to 0.05 La, 0.4 to 0.6 W, 0.1 to 0.35 C, up to 0.002 B, 0.001 to 0.02 N, balance Ni.
FILED	Monday, November 12, 2018
APPL NO	16/188253
ART UNIT	1796 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Alloys C22C 19/056 (20130101) Original (OR) Class C22C 19/057 (20130101)
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10746128 — Cylinder bore having variable coating

US 10746128	Maki et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Ford Motor Company (Dearborn, Michigan)
ASSIGNEE(S)	Ford Motor Company (Dearborn, Michigan)
INVENTOR(S)	Clifford E Maki (New Hudson, Michigan); Larry Dean Elie (Ypsilanti, Michigan); Timothy George Beyer (Troy, Michigan); Arup Kumar Gangopadhyay (Novi, Michigan); Hamed Ghaednia (West Bloomfield, Michigan); James Maurice Boileau (Novi, Michigan)
ABSTRACT	Engine blocks and methods of forming the same are disclosed. The engine block may comprise a body including at least one cylindrical engine bore wall having a longitudinal axis and including a coating extending along the longitudinal axis and having a coating thickness. The coating may have a middle region and first and second end regions, and a plurality of pores may be dispersed within the coating thickness. The middle region may have a different average porosity than one or both of the end regions. The method may include spraying a first porosity coating in a middle longitudinal region of the bore and spraying a second porosity coating in one or more end regions of the bore. The first porosity may be greater than the second porosity and the first and second porosities may be formed during the spraying steps. The pores may act as wells for lubricant.
FILED	Monday, November 18, 2019
APPL NO	16/686962
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 1/08 (20130101) B05D 2202/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/02 (20130101) C23C 4/08 (20130101) C23C 4/129 (20160101) C23C 4/131 (20160101) Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 1/004 (20130101) Original (OR) Class
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10746558 — Method and system for routing based on a predicted connectivity quality

US 10746558	Muldoon et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
ASSIGNEE(S)	GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
INVENTOR(S)	Steven E. Muldoon (Royal Oak, Michigan); Yiran Hu (Shelby Township, Michigan); Junfeng Zhao (Troy, Michigan); Vivek Vijaya Kumar (Shelby Township, Michigan)
ABSTRACT	A system and method for routing based on a predicted connectivity quality is disclosed. The method includes receiving, by a controller, map information corresponding to a geographical area. The method also includes receiving, by the controller, wireless connectivity information corresponding to the geographical area. The method also includes generating output data of at least one route between a starting location and a destination location within the geographical area. The generating is based on the wireless connectivity information.
FILED	Friday, January 26, 2018
APPL NO	15/880918
ART UNIT	3649 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3453 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/024 (20180201) H04W 4/40 (20180201) H04W 4/44 (20180201) H04W 4/46 (20180201) H04W 24/08 (20130101) H04W 36/32 (20130101) H04W 40/20 (20130101)
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10746649 — Real time numerical computation of corrosion rates from corrosion sensors

US 10746649	Klein et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Levente I. Klein (Tuckahoe, New York); Dennis G. Manzer (Bedford Hills, New York)
ABSTRACT	A method for determining a corrosion rate includes receiving an input signal including corrosion data from a sensor. A signal-to-noise ratio (SNR) and a type of noise is determined from the input signal. A corrosion rate computation method is selected based on the SNR and the type of noise. The corrosion rate is determined, using a processor, based on a selected corrosion rate computation method.
FILED	Tuesday, April 02, 2019
APPL NO	16/372658
ART UNIT	2857 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 17/02 (20130101) G01N 17/04 (20130101) G01N 17/043 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 29/26 (20130101) Electric Digital Data Processing G06F 17/18 (20130101)
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10746868 — Synthetic-aperture radar (SAR) imaging with range-resolved reflection data

US 10746868	Carlsten et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Bruce Carlsten (Los Alamos, New Mexico); Stephen Judd (Los Alamos, New Mexico)
ABSTRACT	SAR imaging may be performed with range-resolved reflection data, where a spread-spectrum signal, such as a code division multiple access (CDMA) signal, is transmitted instead of a simple frequency chirp. The reflected spread-spectrum signal may be analyzed to gather range-resolved reflection data. Range-resolved reflection data may be gathered at each angular view. This data may be used to construct a more accurate approximation of the Fourier transform of the desired image than can be done by a conventional SAR approach. The image may be reconstructed from this Fourier transform using Fourier inversion techniques similar to those used in conventional SAR approaches. The range-resolved reflection scheme generally requires somewhat more processing to recover the image as compared with conventional SAR systems, but provides a significantly more stable image with less degradation from effects that plague conventional SAR systems. This can eliminate the need for phase coherency altogether and also eliminate “phase drift,” which leads to image distortion. This may be especially well suited for high resolution imaging of relatively large targets.
FILED	Monday, July 03, 2017
APPL NO	15/640717
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/90 (20130101) Original (OR) Class G01S 13/0209 (20130101)
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10747033 — Cooler for optics transmitting high intensity light

US 10747033	DeMuth et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	James A. DeMuth (Livermore, California); Eric B. Duoss (Dublin, California); Joshua D. Kuntz (Livermore, California); Paul A. Rosso (Livermore, California); Christopher M. Spadaccini (Oakland, California)
ABSTRACT	A system and an apparatus having an optic and a cooling system for cooling the optic. In one example an optically addressed light valve forms the optic. The cooling system includes first and second windows on opposing surfaces of the optically addressed light valve which constrain a cooling fluid to flow over the opposing surfaces. The fluid pressure outside the optically addressed light valve is low enough that it does not compress a liquid crystal gap of the optically addressed light valve. The cooling fluid is also transparent to a high powered light beam which is projected through the first and second windows, and also through the optically addressed light valve, during an additive manufacturing operation.
FILED	Friday, January 29, 2016
APPL NO	15/010188
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1055 (20130101) B22F 2003/1056 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/268 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0126 (20130101) G02F 1/132 (20130101) Original (OR) Class G02F 1/135 (20130101)
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10748687 — Methods of making a component with variable magnetization and related components

US 10748687	Zhang et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Wanming Zhang (Clifton Park, New York); Min Zou (Niskayuna, New York); Francis Johnson (Clifton Park, New York)
ABSTRACT	A method of forming a component having a variation in saturation magnetization is presented. The method includes selectively diffusing nitrogen into a metallic component of a masked metallic component by exposing the masked metallic component to a nitrogen-rich atmosphere. The masked metallic component includes a patterned oxide layer formed on a surface of the metallic component, and the patterned oxide layer includes an oxide of a metal present in the metallic component. A related component is also presented.
FILED	Monday, March 12, 2018
APPL NO	15/918359
ART UNIT	1796 — Electrical Circuits and Systems
CURRENT CPC	Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/18 (20130101) H01F 1/147 (20130101) Original (OR) Class H01F 3/02 (20130101) H01F 41/02 (20130101) H01F 41/0233 (20130101) H01F 2003/106 (20130101) Dynamo-electric Machines H02K 1/02 (20130101) H02K 1/06 (20130101) H02K 1/246 (20130101) H02K 15/02 (20130101)
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10749050 — Thin film CZTSSe photovoltaic device

US 10749050	Haight et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Richard A. Haight (Mahopac, New York); James B. Hannon (Lake Lincolndale, New York); Satoshi Oida (Yorktown Heights, New York)
ABSTRACT	A method for forming a back contact on an absorber layer in a photovoltaic device includes forming a two dimensional material on a first substrate. An absorber layer including Cu—Zn—Sn—S(Se) (CZTSSe) is grown over the first substrate on the two dimensional material. A buffer layer is grown on the absorber layer on a side opposite the two dimensional material. The absorber layer is exfoliated from the two dimensional material to remove the first substrate from a backside of the absorber layer opposite the buffer layer. A back contact is deposited on the absorber layer.
FILED	Monday, January 09, 2017
APPL NO	15/401381
ART UNIT	2813 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/072 (20130101) H01L 31/0324 (20130101) H01L 31/0326 (20130101) H01L 31/0445 (20141201) H01L 31/1892 (20130101) H01L 31/1896 (20130101) H01L 31/02168 (20130101) H01L 31/03923 (20130101) H01L 31/03925 (20130101) H01L 31/03926 (20130101) H01L 31/022425 (20130101) H01L 31/022441 (20130101) Original (OR) Class H01L 31/022466 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101)
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10749052 — Methods of forming interdigitated back contact solar cells

US 10749052	Young et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S)	David Levi Young (Golden, Colorado); Myles Aaron Steiner (Denver, Colorado); John David Simon (Littleton, Colorado)
ABSTRACT	Methods for forming interdigitated back contact solar cells from III-V materials are provided. According to an aspect of the invention, a method includes depositing a patterned Zn layer to cover first areas of an n-type emitter region, wherein the emitter region comprises a III-V material, and forming a passivated back contact region by counter-doping the first areas of the emitter region by diffusing Zn from the patterned Zn layer into the first areas of the emitter region, such that the first areas of the emitter region become p-type.
FILED	Tuesday, February 13, 2018
APPL NO	15/895183
ART UNIT	1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/047 (20141201) H01L 31/0682 (20130101) H01L 31/0693 (20130101) H01L 31/0735 (20130101) H01L 31/1844 (20130101) H01L 31/1868 (20130101) H01L 31/1892 (20130101) H01L 31/03042 (20130101) H01L 31/03046 (20130101) H01L 31/022441 (20130101) H01L 31/022458 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/544 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/521 (20151101)
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10749170 — Graphene-coated metal oxide spinel cathodes

US 10749170	Hersam et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois); UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois); UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S)	Mark C. Hersam (Wilmette, Illinois); Laila Jaber Ansari (Mountain View, California); Kanan P. Puntambekar (Cupertino, California); Michael M. Thackeray (Naperville, Illinois)
ABSTRACT	Disclosed herein are graphene-coated lithium manganese oxide spinels cathodes for high-performance batteries Li-ion batteries and methods for making thereof. A single-layer graphene coating is shown to significantly reduce manganese loss in the cathodes while concurrently promoting the formation of a well-defined solid electrolyte interphase layer.
FILED	Friday, October 14, 2016
APPL NO	15/293909
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/0402 (20130101) H01M 4/0426 (20130101) H01M 4/0428 (20130101) H01M 4/0445 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/628 (20130101) H01M 4/1391 (20130101) H01M 10/052 (20130101) H01M 10/446 (20130101) H01M 10/0525 (20130101) H01M 10/0569 (20130101) H01M 2004/021 (20130101) H01M 2004/028 (20130101) H01M 2300/0037 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/7011 (20130101)
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10749180 — Rechargeable alkaline battery using organic materials as negative electrodes

US 10749180	Yao et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	University of Houston System (Houston, Texas)
ASSIGNEE(S)	UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas)
INVENTOR(S)	Yan Yao (Pearland, Texas); Yanliang Liang (Houston, Texas)
ABSTRACT	An energy storage device may provide a positive electrode, an electrolyte, and a negative electrode. The energy storage device may utilize an aqueous alkaline electrolyte, which may be nonflammable. The energy storage device may utilize organic material(s) as the negative electrode, such as, but not limited to, poly(anthraquinonyl sulfide) (PAQS), organic carbonyl compounds, organosulfur compounds, redox polymers, or radical polymers.
FILED	Tuesday, June 26, 2018
APPL NO	16/018318
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/24 (20130101) H01M 4/32 (20130101) H01M 4/043 (20130101) H01M 4/60 (20130101) H01M 4/602 (20130101) Original (OR) Class H01M 4/622 (20130101) H01M 4/624 (20130101) H01M 10/24 (20130101) H01M 10/28 (20130101) H01M 10/30 (20130101) H01M 2004/027 (20130101)
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10749201 — Regenerative fuel cell

US 10749201	Bahar et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Xergy Inc. (Georgetown, Delaware)
ASSIGNEE(S)	Xergy Inc. (Harrington, Delaware)
INVENTOR(S)	Bamdad Bahar (Georgetown, Delaware); Jacob Zerby (Harbeson, Delaware); Scott Fackler (Harrington, Delaware)
ABSTRACT	A regenerative fuel cell produces hydrogen that is stored in a reservoir on the storage side of a membrane electrode assembly when operating in a hydrogen pumping mode and this stored hydrogen is reacted and moved back through the membrane electrode assembly to form water when operating in a fuel cell mode. A metal hydride forming alloy may be configured in the hydrogen storage reservoir and may be coupled to the membrane electrode assembly. An integral metal hydride electrode having a metal hydride forming alloy may be configured on the storage side of the membrane electrode assembly and may have a catalyst or an ion conductive media incorporated therewith.
FILED	Monday, August 06, 2018
APPL NO	16/056116
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 3/0031 (20130101) C01B 3/065 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/186 (20130101) Original (OR) Class H01M 8/1004 (20130101) H01M 8/04007 (20130101) H01M 8/04067 (20130101) H01M 8/04089 (20130101) H01M 8/04201 (20130101) H01M 8/04216 (20130101) H01M 2008/1095 (20130101)
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10749385 — Dual magnetic phase material rings for AC electric machines

US 10749385	Reddy et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
INVENTOR(S)	Patel Bhageerath Reddy (Niskayuna, New York); Min Zou (Schenectady, New York); Ayman Mohamed Fawzi El-Refaie (Milwaukee, Wisconsin); Francis Johnson (Clifton Park, New York)
ABSTRACT	An AC electric machine that includes a dual magnetic phase material ring is disclosed. The AC electric machine includes a stator assembly and a rotor assembly positioned within the stator assembly and configured to rotate relative thereto, the rotor assembly comprising a rotor core including a stack of rotor laminations that collectively form the rotor core, the rotor core including a plurality of rotor poles separated by gaps therebetween. The AC electric machine also includes a dual magnetic phase material ring positioned about the stack of rotor laminations, the dual magnetic phase material ring comprising a first ring portion comprising a magnetic portion and a second ring portion comprising a non-magnetic portion.
FILED	Thursday, May 18, 2017
APPL NO	15/598408
ART UNIT	2834 — Electrical Circuits and Systems
CURRENT CPC	Dynamo-electric Machines H02K 1/02 (20130101) Original (OR) Class H02K 1/22 (20130101) H02K 1/246 (20130101) H02K 17/165 (20130101) H02K 19/24 (20130101) H02K 19/103 (20130101)
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10749434 — Power converter with capacitive energy transfer and fast dynamic response

US 10749434	Giuliano et al.
FUNDED BY	Department of Defense (DOD) Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	David M. Giuliano (Cambridge, Massachusetts); David J. Perreault (Cambridge, Massachusetts); Robert C. N. Pilawa-Podgurski (Cambridge, Massachusetts)
ABSTRACT	A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices.
FILED	Wednesday, November 27, 2019
APPL NO	16/697318
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/07 (20130101) H02M 3/155 (20130101) H02M 3/158 (20130101) Original (OR) Class H02M 2001/007 (20130101)
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10749446 — Virtual synchronous generator system and method with virtual inertia control

US 10749446	Gong
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Maozhong Gong (Niskayuna, New York)
ABSTRACT	A virtual synchronous generator device disclosed. The device includes an inverter and inverter controller having a power control portion, a power reserve portion, a power point tracking control portion, and a virtual inertia control portion. The power reserve portion determines an amount of power to be reserved and sends a signal, indicative of the determined amount of power to the power point tracking controller. The power point tracking controller determines a power point that is less than a MPP, and provides a signal to the power control portion indicative of the determined power point. The inertia control portion determines a virtual inertia and provides a signal indicative of the virtual inertia to the power control portion. The power control portion provides a power control signal to the inverter based on the power point tracking signal and the inertia command signal.
FILED	Wednesday, January 02, 2019
APPL NO	16/238516
ART UNIT	2839 — Electrical Circuits and Systems
CURRENT CPC	Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/385 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/53871 (20130101) Original (OR) Class
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10749817 — High-density, fail-in-place switches for computer and data networks

US 10749817	Coteus et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Paul W. Coteus (Yorktown, New York); Fuad E. Doany (Katonah, New York); Shawn A. Hall (Pleasantville, New York); Mark D. Schultz (Ossining, New York); Todd E. Takken (Brewster, New York); Shurong Tian (Mount Kisco, New York)
ABSTRACT	A structure for a network switch. The network switch may include a plurality of spine chips arranged on a plurality of spine cards, where one or more spine chips are located on each spine card; and a plurality of leaf chips arranged on a plurality of leaf cards, wherein one or more leaf chips are located on each leaf card, where each spine card is connected to every leaf chip and the plurality of spine chips are surrounded on at least two sides by leaf cards.
FILED	Wednesday, September 19, 2018
APPL NO	16/135172
ART UNIT	2835 — Electrical Circuits and Systems
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 49/109 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20254 (20130101) H05K 7/20309 (20130101) H05K 7/20318 (20130101) H05K 7/20509 (20130101) H05K 7/20572 (20130101) H05K 7/20763 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Science Foundation (NSF)

10744461 — Ultrafiltration membrane based on bacterial nanocellulose and graphene oxide

US 10744461	Singamaneni et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Srikanth Singamaneni (St. Louis, Missouri); Young-Shin Jun (St. Louis, Missouri); Qisheng Jiang (St. Louis, Missouri); Deoukchen Ghim (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Srikanth Singamaneni (St. Louis, Missouri); Young-Shin Jun (St. Louis, Missouri); Qisheng Jiang (St. Louis, Missouri); Deoukchen Ghim (St. Louis, Missouri)
ABSTRACT	The present disclosure is directed to ultrafiltration membranes based on bacterial nanocellulose and graphene oxide. In particular, the present disclosure is directed to the novel design and incorporation of membranes for realizing new, highly efficient, and environmentally-friendly anti-biofouling membranes for water purification.
FILED	Thursday, February 14, 2019
APPL NO	16/276106
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Separation B01D 61/145 (20130101) Original (OR) Class B01D 65/08 (20130101) B01D 67/0079 (20130101) B01D 67/0095 (20130101) B01D 69/06 (20130101) B01D 69/148 (20130101) B01D 71/08 (20130101) B01D 71/10 (20130101) B01D 71/024 (20130101) B01D 2323/40 (20130101) B01D 2325/02 (20130101) B01D 2325/48 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 1/00 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/10 (20130101) C02F 1/14 (20130101) C02F 1/444 (20130101) C02F 2303/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 1/22 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 70/10 (20180501) F24S 2080/017 (20180501) Technologies for Adaptation to Climate Change Y02A 20/212 (20180101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/59 (20151101) Y02P 20/134 (20151101) Y02P 20/136 (20151101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 10/37 (20150501)
VIEW PATENT	@ USPTO: Full Text PDF

10745320 — Compositions of matter comprising nanoparticles and non-conductive substrates

US 10745320	Thostenson
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) National Science Foundation (NSF) Department of Transportation (USDOT) Federal Highway Administration (FHWA) National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S)	University of Delaware (Newark, Delaware)
ASSIGNEE(S)	University of Delaware (Newark, Delaware)
INVENTOR(S)	Erik Thostenson (Newark, Delaware)
ABSTRACT	In various aspects, the processes disclosed herein may include the steps of inducing an electric field about a non-conductive substrate, and depositing functionalized nanoparticles upon the non-conductive substrate by contacting a nanoparticle dispersion with the non-conductive substrate, the nanoparticle dispersion comprising functionalized nanoparticles having an electrical charge, the electric field drawing the functionalized nanoparticles to the non-conductive substrate. In various aspects, the related composition of matter disclosed herein comprise functionalized nanoparticles bonded to a surface of a non-conductive fiber, the surface of the non-conductive fiber comprising a sizing adhered to the surface of the non-conductive fiber. This Abstract is presented to meet requirements of 37 C.F.R. § 1.72(b) only. This Abstract is not intended to identify key elements of the processes, and related apparatus and compositions of matter disclosed herein or to delineate the scope thereof.
FILED	Wednesday, August 09, 2017
APPL NO	15/672931
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/44 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) C08K 3/042 (20170501) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/4419 (20130101) C09D 7/61 (20180101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) C25D 13/12 (20130101) C25D 13/22 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/254 (20150115)
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10745673 — Heme protein catalysts for carbon-boron bond formation in vitro and in vivo

US 10745673	Kan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	S. B. Jennifer Kan (Pasadena, California); Xiongyi Huang (Pasadena, California); Kai Chen (Pasadena, California)
ABSTRACT	Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the presence of a heme protein, e.g., a cytochrome c, a cytochrome P450, a globin, a protoglobin, a nitric oxide dioxygenase, a peroxidase, or a catalase, or a variant thereof, under conditions sufficient to form the organoboron product. Reaction mixtures for producing organoboron products are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming carbon-boron bonds.
FILED	Wednesday, March 07, 2018
APPL NO	15/914788
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0053 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/10 (20130101) C12P 17/12 (20130101) Enzymes C12Y 109/03001 (20130101)
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10745674 — Polyketide synthase variants and uses thereof

US 10745674	Noel et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Joseph Noel (La Jolla, California); Kate Woods (La Jolla, California); Marianne Bowman (La Jolla, California); Gordon Louie (La Jolla, California); Nancy Anderson Da Silva (Oakland, California); Javier Pascual Cardenas (Oakland, California)
ABSTRACT	The present invention relates to methods for producing polyketide synthase variants, and for altering the activity and/or substrate specificity of putative native and variant polyketide synthases. The present invention further relates to compositions comprising said polyketide synthase variants, compounds prepared using said polyketide synthase variants, and uses of said polyketide synthase variants. In one embodiment, said polyketide synthase variant is 2-pyrone synthase.
FILED	Thursday, March 05, 2015
APPL NO	15/123501
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1029 (20130101) Original (OR) Class C12N 15/52 (20130101) Enzymes C12Y 203/01 (20130101)
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10745708 — Transgenic plants with engineered redox sensitive modulation of photosynthetic antenna complex pigments and methods for making the same

US 10745708	Sayre
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Basic Energy Sciences (BES) Energy Frontier Research Centers (EFRC) Center for Advanced Biofuel Systems (CABS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Emerging Frontiers (EF)
APPLICANT(S)	NMC, INC. (Los Alamos, New Mexico)
ASSIGNEE(S)	NMC, INC. (Los Alamos, New Mexico)
INVENTOR(S)	Richard Thomas Sayre (Los Alamos, New Mexico)
ABSTRACT	Embodiments of the present invention provide for a transgenic plan, methods of making and DNA constructs for use in the transgenic plant which transgenic plant is capable of modulating its photosynthetic antenna complex composition in response to increases or decreases in light intensity by modulation of the ratio of chlorophyll a to chlorophyll b such that there is an increase in the Chl a/b ratio at high light intensity and a decrease in the Chl a/b ratio at low light intensity versus wild-type plants grown in the same conditions.
FILED	Friday, May 12, 2017
APPL NO	15/594274
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0073 (20130101) C12N 15/825 (20130101) C12N 15/8222 (20130101) C12N 15/8237 (20130101) Original (OR) Class C12N 15/8245 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) Enzymes C12Y 114/13122 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101)
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10745714 — RNA-guided gene editing and gene regulation

US 10745714	Gersbach et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA) NIH Office of the Director (NIHOD) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Charles A. Gersbach (Durham, North Carolina); Isaac B. Hilton (Durham, North Carolina); Pablo Perez-Pinera (Urbana, Illinois); Ami M. Kabadi (Greensboro, North Carolina); Pratiksha I. Thakore (Durham, Illinois); David G. Ousterout (Raleigh, North Carolina); Joshua B. Black (Durham, North Carolina)
ABSTRACT	Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
FILED	Tuesday, May 29, 2018
APPL NO	15/991333
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/005 (20130101) A61K 48/0058 (20130101) Peptides C07K 14/4708 (20130101) C07K 2319/71 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2740/16043 (20130101) C12N 2800/40 (20130101) C12N 2840/20 (20130101) Enzymes C12Y 301/00 (20130101)
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10745722 — Engineered strain of Escherichia coli for production of poly-R-3-hydroxyalkanoate polymers with defined monomer unit composition and methods based thereon

US 10745722	Nomura et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York)
ASSIGNEE(S)	The Research Foundation for The State University of New York (Albany, New York)
INVENTOR(S)	Christopher T. Nomura (Syracuse, New York); Ryan C. Tappel (Syracuse, New York); Qin Wang (Syracuse, New York)
ABSTRACT	Methods and systems for producing prescribed unit size poly(3-hydroxyalkanoate) (PHA) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of PHA or lack enzymes to degrade PHA once synthesized, metabolize short to long chain fatty acids without induction, and express an (R)-specific enoyl-CoA hydratase and a PHA synthase, the (R)-specific enoyl-CoA hydratase and PHA synthase having wide substrate specificities. The recombinant bacteria are fed at least one fatty acid substrate that is equal in carbon length to the prescribed or desired unit size of the PHA polymer to be produced. The prescribed unit size PHA that is produced is then isolated and/or purified.
FILED	Friday, July 14, 2017
APPL NO	15/650265
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 9/1029 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/62 (20130101) Original (OR) Class C12P 7/625 (20130101) Enzymes C12Y 203/01 (20130101) C12Y 402/01017 (20130101) C12Y 402/01055 (20130101)
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10745762 — Method and system for synthesizing a target polynucleotide within a droplet

US 10745762	Abate et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Adam R. Abate (Daly City, California); Dennis Jay Eastburn (Burlingame, California); Adam R. Sciambi (San Francisco, California)
ABSTRACT	The disclosed embodiments relate to method, system and apparatus for synthesizing a target polynucleotide within a droplet. In an exemplary embodiment, the disclosure provides a method of synthesizing a target polynucleotide. The method includes the steps of: contacting a polynucleotide-containing component from a sample with lysis reagents in a droplet, the lysis reagents comprising an enzyme having protease activity, wherein the droplet is encapsulated with an immiscible carrier fluid; moving the droplet into a collection reservoir; incubating the droplet in the collection reservoir for a first duration and then inactivating the enzyme having protease activity; adding to the droplet a nucleic acid synthesis reagent to form a nucleic acid synthesis droplet in the immiscible carrier fluid to form a nucleic acid droplet; and synthesizing the target polynucleotide within the nucleic acid synthesis droplet.
FILED	Tuesday, February 19, 2019
APPL NO	16/279905
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 3/0807 (20130101) B01F 5/0652 (20130101) B01F 13/0062 (20130101) B01F 13/0076 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) B01L 7/52 (20130101) B01L 2200/0652 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2300/0883 (20130101) B01L 2300/1822 (20130101) B01L 2400/0415 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/686 (20130101) C12Q 1/6806 (20130101) C12Q 1/6806 (20130101) C12Q 1/6844 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2537/143 (20130101) C12Q 2563/159 (20130101) C12Q 2563/159 (20130101) C12Q 2565/629 (20130101) C12Q 2600/16 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101)
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10745816 — Transfer of vertically aligned ultra-high density nanowires onto flexible substrates

US 10745816	Xu et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida)
INVENTOR(S)	Cheng Xu (Chandler, Arizona); Kirk Jeremy Ziegler (Gainesville, Florida); Jie Liu (Greer, South Carolina)
ABSTRACT	Various examples are provided for vertically aligned ultra-high density nanowires and their transfer onto flexible substrates. In one example, a method includes forming a plurality of vertically aligned nanowires inside channels of an anodized alumina (AAO) template on an aluminum substrate, where individual nanowires of the plurality of vertically aligned nanowires extend to a distal end from a proximal end adjacent to the aluminum substrate; removing the aluminum substrate and a portion of the AAO template to expose a surface of the AAO template and a portion of the proximal end of the individual nanowires; depositing an interlayer on the exposed surface of the AAO template and the exposed portion of the individual nanowires; and removing the AAO template from around the plurality of vertically aligned nanowires embedded in the interlayer.
FILED	Monday, October 24, 2016
APPL NO	15/766589
ART UNIT	1715 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/04 (20130101) C25D 1/006 (20130101) Original (OR) Class C25D 11/045 (20130101)
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10746630 — Single-shot network analyzer (SINA)

US 10746630	Jalali et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Bahram Jalali (Los Angeles, California); Cejo Lonappan (Los Angeles, California); Asad Madni (Los Angeles, California)
ABSTRACT	Apparatus and/or method for performing single-shot network analysis of electrical, electronic and electro-optical elements (e.g., components, circuits, modules, sub-systems and/or systems) on a device, or devices, under test (DUT). A pulsed optical source is directed through a first dispersion element to an modulator, while a delayed version of the pulsed optical source is directed to the DUT (pulsed optical source converted to electrical signal if DUT has electrical input), whose electrical output is fed to the modulator whose modulated optical pulse output is stretched through a second optical dispersion element, then converted to an electrical signal and processed to provide analysis and/or display of DUT response.
FILED	Wednesday, December 19, 2018
APPL NO	16/225144
ART UNIT	2886 — Optics
CURRENT CPC	Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/333 (20130101) Original (OR) Class G01M 11/3118 (20130101) G01M 11/3145 (20130101) G01M 11/3172 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/36 (20130101) G06K 9/209 (20130101) G06K 9/00523 (20130101) G06K 9/00536 (20130101) Transmission H04B 10/0731 (20130101)
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10746852 — Vital signs monitoring via radio reflections

US 10746852	Adib et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Fadel Adib (Cambridge, Massachusetts); Zachary Edward Kabelac (Somerville, Massachusetts); Dina Katabi (Cambridge, Massachusetts)
ABSTRACT	A method for monitoring periodic motions of one or more subjects uses signal reflections from the subjects. The method includes emitting a transmitted signal from a transmitting antenna and receiving a received signal at one or more receiving antennas. The received signal includes a combination of a number of reflections of the transmitted signal, at least some of which are associated with the subjects. The received signal, including the reflections, is processed to determine an estimate of a fundamental frequency of the periodic motions.
FILED	Tuesday, April 28, 2015
APPL NO	15/307607
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/113 (20130101) A61B 5/0255 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/415 (20130101) Original (OR) Class G01S 13/536 (20130101)
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10747999 — Methods and systems for pattern characteristic detection

US 10747999	DeChant et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York); Cornell University (Ithaca, New York)
INVENTOR(S)	Alan Chad DeChant (New York, New York); Hod Lipson (New York, New York); Rebecca J. Nelson (New York, New York); Michael A. Gore (New York, New York); Tyr Wiesner-Hanks (New York, New York); Ethan Stewart (New York, New York); Jason Yosinski (New York, New York); Siyuan Chen (New York, New York)
ABSTRACT	Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method to detect pattern characteristics in target specimens that includes acquiring sensor data for the target specimens, dividing the acquired sensor data into a plurality of data segments, and generating, by multiple neural networks that each receives the plurality of data segments, multiple respective output matrices, with each data element of the multiple respective output matrices being representative of a probability that corresponding sensor data of a respective one of the plurality of data segments includes a pattern characteristic in the target specimens. The method further includes determining by another neural network, based on the multiple respective output matrices generated by the multiple neural networks, a presence of the pattern characteristic in the target specimens.
FILED	Tuesday, October 16, 2018
APPL NO	16/161499
ART UNIT	2645 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Soil Working in Agriculture or Forestry; Parts, Details, or Accessories of Agricultural Machines or Implements, in General A01B 79/005 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00657 (20130101) Original (OR) Class G06K 9/00671 (20130101) G06K 9/4628 (20130101) G06K 9/6273 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/084 (20130101) G06N 3/0454 (20130101) G06N 5/046 (20130101)
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10748453 — Myringotomy surgical training device with real-time and stored feedback on performance

US 10748453	Jabbour et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh-Of the Commonwealth Systems of the Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Noel Jabbour (Pittsburgh, Pennsylvania); Jonathan M. Kenneson (Clarion, Pennsylvania); Molly E. Knewtson (Pittsburgh, Pennsylvania); Joseph T. Samosky (Pittsburgh, Pennsylvania)
ABSTRACT	A system for performing a myringotomy training procedure placing a tympanostomy tube in a simulated ear drum of a patient includes a canal structure. The canal structure includes a tubular portion having an inner surface formed from a conductive material disposed about a longitudinal axis, the tubular portion having a first end, an opposite second end; and a thin membrane selectively coupled to the second end of the tubular portion.
FILED	Friday, May 19, 2017
APPL NO	15/599964
ART UNIT	3715 — Amusement and Education Devices
CURRENT CPC	Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 9/00 (20130101) G09B 23/34 (20130101) Original (OR) Class
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10749450 — Electrostatic clutch

US 10749450	Majidi et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	CARNEGIE MELLON UNIVERSITY, a Pennsylvania Non-Profit Corporation (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	CARNEGIE MELLON UNIVERSITY, a Pennsylvania Non-Profit Corporation (Pittsburgh, Pennsylvania)
INVENTOR(S)	Carmel Majidi (Pittsburgh, Pennsylvania); Steven Collins (Pittsburgh, Pennsylvania); Stuart Diller (Pittsburgh, Pennsylvania)
ABSTRACT	An electrostatic clutch is described comprising a plurality of micron-scale thickness electrodes, adjacent electrodes being separated by a thin film of dielectric material. A power source and controller apply a voltage across two electrodes, causing an electrostatic force to develop. When engaged, a force can be transferred through the clutch. A tensioning device maintains the alignment of the clutch when the electrodes are disengaged, but permits movement in at least one direction. In some embodiments, multiple clutches are connected to an output to provide variable force control and a broad range of torque input and output values. Moreover, the clutch can be used as an energy-recycling actuator that captures mechanical energy from negative work movements, and returns energy during positive work movements.
FILED	Monday, June 03, 2019
APPL NO	16/429924
ART UNIT	3655 — Material and Article Handling
CURRENT CPC	Couplings for Transmitting Rotation; Clutches; Brakes F16D 27/00 (20130101) F16D 28/00 (20130101) Electric Machines Not Otherwise Provided for H02N 13/00 (20130101) Original (OR) Class
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10749472 — Frequency-converting super-regenerative transceiver

US 10749472	Rocheleau et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	Tristan Orion Rocheleau (Berkeley, California); Thura Lin Naing (Union City, California)
ASSIGNEE(S)	MuMec, Inc. (Oakland, California)
INVENTOR(S)	Tristan Orion Rocheleau (Berkeley, California); Thura Lin Naing (Union City, California)
ABSTRACT	The present disclosure provides a frequency-converting super regenerative transceiver with a frequency mixer coupled to a resonator and a feedback element having a controllable gain. The frequency-converting super-regenerative transceiver utilizes the frequency mixer to shift the incoming frequencies, based on a controlled oscillator, to match the frequency of operation of the super-regenerative transceiver. The frequency-converting super-regenerative transceivers described herein permit signal data capture over a broad range of frequencies and for a range of communication protocols. The frequency-converting super-regenerative transceivers described herein are tunable, consume very little power for operation and maintenance, and permit long term operation even when powered by very small power sources (e.g., coin batteries).
FILED	Sunday, February 11, 2018
APPL NO	16/314656
ART UNIT	2655 — Digital Audio Data Processing
CURRENT CPC	Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 5/30 (20130101) H03B 5/32 (20130101) Original (OR) Class H03B 5/323 (20130101) H03B 5/1215 (20130101) Demodulation or Transference of Modulation From One Carrier to Another H03D 11/04 (20130101) H03D 11/08 (20130101) H03D 2200/0074 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 3/02 (20130101) H03H 9/02228 (20130101) H03H 9/02259 (20130101) H03H 9/02393 (20130101) H03H 9/2447 (20130101) H03H 9/2457 (20130101) H03H 2003/027 (20130101) Transmission H04B 1/16 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/127 (20130101)
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10749991 — Emulation-based cross-technology communication

US 10749991	He et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Tian He (Arden Hills, Minnesota); Zhijun Li (Minneapolis, Minnesota); Ruofeng Liu (Minneapolis, Minnesota); Wenchao Jiang (Minneapolis, Minnesota)
ABSTRACT	In general, a system is described that includes two computing devices, a first which is configured to operate using a first wireless protocol and a second which is configured to operate using a second wireless protocol different than the first wireless protocol. The first computing device may determine a symbol to be sent to the second computing device. For each bit included in a payload of a data packet, the first computing device may set a value of the respective bit such that the symbol, when the data packet is translated into at least one signal using the first wireless protocol, is readable using the second wireless protocol. The first computing device generates the signal using the first wireless protocol, and outputs, via the first wireless protocol, the at least one signal. The second computing device may receive the at least one signal and demodulate the payload.
FILED	Thursday, May 31, 2018
APPL NO	15/994472
ART UNIT	2636 — Optical Communications
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0083 (20130101) H04L 1/0084 (20130101) H04L 27/0008 (20130101) H04L 27/36 (20130101) H04L 27/2273 (20130101) H04L 27/2636 (20130101) H04L 27/2646 (20130101) H04L 69/08 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/80 (20180201) H04W 16/14 (20130101) H04W 80/00 (20130101)
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10750618 — System and method for manufacture of circuit boards

US 10750618	Garmire et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	University of Hawaii (Honolulu, Hawaii)
ASSIGNEE(S)	University of Hawaii (Honolulu, Hawaii)
INVENTOR(S)	David Garmire (Ann Arbor, Michigan); Jie Zhou (Honolulu, Hawaii); Tamra Oyama (Honolulu, Hawaii)
ABSTRACT	Methods, systems, and apparatus for fabricating a circuit board. The method includes fabricating, using an additive manufacturing device, a trace layer, a sacrificial layer, a rail layer and a lid. The method includes placing the sacrificial layer on the trace layer such that the raised traces protrude through corresponding openings of the sacrificial layer. The method includes depositing a conductive material on top of the sacrificial layer and the plurality of traces. The method includes removing the sacrificial layer from the trace layer and placing the rail layer on the trace layer such that the raised traces align with the corresponding openings of the rail layer. The method includes connecting one or more electrical components and melting a sealing sheet on top of the rail layer and the electrical components to reinforce connections and to provide protection. The method includes placing the lid on top of the sealing sheet.
FILED	Tuesday, April 16, 2019
APPL NO	16/386191
ART UNIT	1713 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 3/184 (20130101) Original (OR) Class H05K 3/381 (20130101) H05K 3/387 (20130101)
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National Aeronautics and Space Administration (NASA)

10745112 — Method and system for delaying laminar-to-turbulent transition in high-speed boundary layer flow

US 10745112	Paredes Gonzalez et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	U.S.A. AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINSTRATOR OF NASA (Washington, District of Columbia)
INVENTOR(S)	Pedro Paredes Gonzalez (Hampton, Virginia); Meelan M. Choudhari (Yorktown, Virginia); Fei Li (Newport News, Virginia)
ABSTRACT	A method and system delay the laminar-to-turbulent transition of a supersonic or hypersonic boundary layer flow moving in a flow direction over a surface. For supersonic boundary layer flow, oblique first-mode instability waves present in the boundary layer and propagating at an oblique angle relative to the flow direction cause a laminar-to-turbulent transition in the boundary layer flow. These instability waves have a wavelength associated therewith in a direction perpendicular to the flow direction. Flow disruptors are used to generate modulations within the boundary layer flow wherein a wavelength of the modulations along the direction perpendicular to the flow direction is less than one-half of the wavelength of the instability waves. For hypersonic boundary layer flow, the flow disruptors generate modulations within the boundary layer flow wherein the wavelength of the modulations is less than streak spacing for optimal transient growth or, equivalently, in the range of one to two times the boundary layer thickness.
FILED	Monday, October 16, 2017
APPL NO	15/784878
ART UNIT	3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 21/04 (20130101) Original (OR) Class B64C 21/08 (20130101) B64C 21/10 (20130101) B64C 23/005 (20130101) B64C 23/06 (20130101) B64C 30/00 (20130101) B64C 2230/04 (20130101) B64C 2230/06 (20130101) B64C 2230/12 (20130101) B64C 2230/26 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/162 (20130101) Y02T 50/166 (20130101)
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10745509 — Methods of making mechanoresponsive healing polymers

US 10745509	Gordon et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
INVENTOR(S)	Keith L. Gordon (Hampton, Virginia); Emilie J. Siochi (Newport News, Virginia)
ABSTRACT	Methods are provided to produce new mechanoresponsive healing systems. Additionally, various embodiments provide a two tier self-healing material system concept that provides a non-intrusive method to mitigate impact damage in a structure ranging from low velocity impact damage (e.g., crack damage) to high velocity impact damage (e.g., ballistic damage.) The various embodiments provide the mechanophore linked polymer PBG-BCB-PBG. The various embodiments provide methods for synthesizing PBG-BCB-PBG.
FILED	Thursday, March 01, 2018
APPL NO	15/909312
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Treatment or Chemical Modification of Rubbers C08C 19/20 (20130101) C08C 19/25 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 255/08 (20130101) C08F 293/00 (20130101) Original (OR) Class
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10746132 — Solenoid-controlled, liquid cryogenic-hydraulically actuated isolation valve assembly

US 10746132	Richard et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	James Andrew Richard (Grant, Alabama); Travis Allen Davis (Belle Fourche, South Dakota); Brad M. Addona (Huntsville, Alabama)
ABSTRACT	The present invention is directed toward a new and improved solenoid-controlled, liquid cryogenic-hydraulically actuated valve assembly wherein, in addition to the valve assembly controlling the flow of liquid cryogenic fluid therethrough, a portion of the liquid cryogenic fluid is effectively utilized to hydraulically actuate and control OPEN and CLOSED valves to predetermined positions such that the flow of cryogenic fluid, through the valve assembly from an inlet flange to an outlet flange of the valve assembly, is permitted or prevented.
FILED	Friday, April 27, 2018
APPL NO	15/964655
ART UNIT	3753 — Fluid Handling and Dispensing
CURRENT CPC	Jet-propulsion Plants F02K 9/58 (20130101) Original (OR) Class Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 24/04 (20130101) F16K 31/1225 (20130101) Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 13/04 (20130101)
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10746478 — Silicon biporous wick for high heat flux heat spreaders

US 10746478	Sunada et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Eric T. Sunada (Alhambra, California); Karl Y. Yee (Pasadena, California); Sean W. Reilly (Pasadena, California)
ABSTRACT	A wicking structure comprising a biporous wick formed with a semiconductor (e.g., silicon), wherein the biporous wick comprises first pores and second pores formed by the semiconductor and the first pores are larger than the second pores.
FILED	Monday, December 12, 2016
APPL NO	15/376288
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/046 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 21/04 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101)
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10746594 — Thermopile bias method for low voltage infrared readout integrated circuits

US 10746594	Quilligan et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Gerard Quilligan (Greenbelt, Maryland); Shahid Aslam (Greenbelt, Maryland); Nicolas Gorius (Washington, District of Columbia); Daniel Glavin (Greenbelt, Maryland); John Kolasinski (Greenbelt, Maryland); Dat Tran (Washington, District of Columbia)
ABSTRACT	An apparatus include one or more DACs and a resistor divider are configured to generate a variable bias voltage V_BIASwith respect to a CM voltage V_CM. The CM voltage V_CMis applied to a cathode of one or more thermopiles or a negative input of one or more amplifiers to prevent saturation and over range of one or more low voltage readout amplifiers and one or more ADCs.
FILED	Monday, August 05, 2019
APPL NO	16/532062
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/16 (20130101) G01J 1/20 (20130101) G01J 1/30 (20130101) G01J 1/42 (20130101) Original (OR) Class G01J 5/12 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/02 (20130101) G01K 7/021 (20130101) Coding; Decoding; Code Conversion in General H03M 1/18 (20130101) H03M 1/187 (20130101)
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10746600 — Dual wavelength context imaging Raman and fluorescence spectrometer

US 10746600	Lambert
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	James L. Lambert (Pasadena, California)
ABSTRACT	Methods and systems for Raman spectroscopy and context imaging are disclosed. One or two lasers can be used to excite Raman scattering in a sample, while a plurality of LEDs can illuminate the sample at a different wavelength. The LED light is collected by a lenslet array in order to enable a high depth of field. Focusing of the image can be carried out at specific points of the image by processing the light collected by the lenslet array.
FILED	Thursday, May 17, 2018
APPL NO	15/983019
ART UNIT	2886 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) G01J 3/18 (20130101) G01J 3/28 (20130101) G01J 3/44 (20130101) Original (OR) Class G01J 3/0208 (20130101) G01J 3/0224 (20130101) G01J 3/0227 (20130101) G01J 3/0237 (20130101) G01J 3/0248 (20130101) G01J 3/2823 (20130101) G01J 3/4406 (20130101) G01J 2003/102 (20130101)
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Department of Agriculture (USDA)

10745335 — Continuous process for the ozonolysis of lignin to yield aromatic monomers

US 10745335	Subramaniam et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	University of Kansas (Lawrence, Kansas)
ASSIGNEE(S)	UNIVERSITY OF KANSAS (Lawrence, Kansas)
INVENTOR(S)	Bala Subramaniam (Lawrence, Kansas); Andrew M. Danby (Lawrence, Kansas); Michael D. Lundin (Lawrence, Kansas)
ABSTRACT	A method for processing lignin may comprise flowing a lignin composition comprising a lignin polymer and a solvent through a reaction chamber of a continuous flow reactor, the lignin polymer comprising hydroxycinnamic groups bound to a polymeric backbone; flowing ozone through the reaction chamber containing the lignin composition under conditions to maximize oxidative cleavage of the hydroxycinnamic groups to produce one or more types of aromatic monomers while minimizing oxidative cleavage of the polymeric backbone; and collecting the one or more types of aromatic monomers, e.g., by a size-selective membrane separation device.
FILED	Thursday, July 13, 2017
APPL NO	16/317173
ART UNIT	1767 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 37/60 (20130101) C07C 37/70 (20130101) C07C 45/40 (20130101) Original (OR) Class C07C 45/786 (20130101) Compounds of Unknown Constitution C07G 1/00 (20130101) Derivatives of Natural Macromolecular Compounds C08H 6/00 (20130101)
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10745675 — Modified enzymes for producing increased isomelezitose

US 10745675	Cote et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S)	Gregory L. Cote (Edwards, Illinois); Christopher D. Skory (Washington, Illinois)
ABSTRACT	Provided herein are compositions and methods for the synthesis of the trisaccharide, isomelezitose, using genetically modified glucansucrase enzymes from representative microorganisms, including lactic acid bacteria such as Leuconostoc mesenteroides. Various modified enzymes are detailed, increasing isomelezitose yields and provide the foundation for large-scale production of isomelezitose for food, industrial and biomedical applications.
FILED	Monday, April 30, 2018
APPL NO	15/966294
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1051 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/00 (20130101) C12P 19/18 (20130101) Enzymes C12Y 204/01005 (20130101)
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10745757 — Compositions and methods for determining likelihood of an increased susceptibility to contracting Johne's disease

US 10745757	Kirkpatrick et al.
FUNDED BY	Department of Agriculture (USDA) Agricultural Research Service (ARS) Cooperative State Research, Education, and Extension Service (CSREES) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Brian W. Kirkpatrick (Fitchburg, Wisconsin); George E. Shook (Middleton, Washington); Michael T. Collins (Madison, Wisconsin)
ABSTRACT	Collections of polynucleotides useful for estimating breeding value or detecting likelihood of an increased susceptibility to contracting paratuberculosis are disclosed. The polynucleotides are used to detect genomic sequences quantitatively associated with an increased susceptibility to contracting paratuberculosis. Methods for using the collections to estimate breeding value or predict likelihood of an increased susceptibility to contracting paratuberculosis are also provided. Kits comprising the collection of polynucleotides are also provided.
FILED	Monday, April 01, 2019
APPL NO	16/371420
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/124 (20130101) C12Q 2600/156 (20130101)
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10748463 — System architecture and method of processing an image therein

US 10748463	Bae et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Euiwon Bae (West Lafayette, Indiana); Huisung Kim (Lafayette, Indiana)
ABSTRACT	A non-transitory computer-readable medium encoded with a computer-readable program, which when executed by a processor, will cause the processor to execute an image processing method, the image processing method including establishing a zero crossing region from a target image onto a screen, wherein the zero crossing region comprises a corresponding value. The method further includes receiving a variable input and an integration time input, wherein the variable input comprises a frequency number for an image accumulation procedure, and wherein the integration time comprises a time period for which an aperture for a sensor receives incoming signals. Additionally, the method includes performing the image accumulation procedure. Moreover, the method includes producing a final greyscale image by adding a plurality of sets of vertically shifted pixel values, wherein the frequency number for the image accumulation procedure ranges from 3 to 20.
FILED	Tuesday, October 30, 2018
APPL NO	16/175752
ART UNIT	2648 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/20 (20130101) G06T 5/50 (20130101) G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) G06T 2207/20182 (20130101) G06T 2207/30072 (20130101) Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/007 (20130101) Original (OR) Class G09G 5/028 (20130101)
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Department of Commerce (DOC)

10743533 — Cold storage of organotypically cultured skin equivalents for clinical applications

US 10743533	Allen-Hoffmann et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST) Advanced Technology Program (NIST-ATP)
APPLICANT(S)	STRATATECH CORPORATION (Madison, Wisconsin)
ASSIGNEE(S)	Stratatech Corporation (Madison, Wisconsin)
INVENTOR(S)	B. Lynn Allen-Hoffmann (Madison, Wisconsin); John Pirnstill (Fitchburg, Wisconsin)
ABSTRACT	The present invention relates generally to systems and methods for storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
FILED	Monday, December 12, 2016
APPL NO	15/375755
ART UNIT	3735 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/02 (20130101) Original (OR) Class A01N 1/0231 (20130101) A01N 1/0263 (20130101) A01N 1/0273 (20130101)
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10745753 — Mouse cell line authentication

US 10745753	Almeida et al.
FUNDED BY	Department of Commerce (DOC)
APPLICANT(S)	United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)	Government of the United States of America, as Represented by the Secretary of Commerce (Gaithersburg, Maryland)
INVENTOR(S)	Jamie Almeida (Eldersburg, Maryland); Kenneth Cole (Gaithersburg, Maryland)
ABSTRACT	A method, kit and primers for determining alleles present in a DNA sample that is sourced from either a mouse or a cell line derived from a mouse. A set of STR marker loci are selected that can be amplified together in a multiplex amplification reaction. The set of STR marker loci are selected from the group consisting of: 18-3, 4-2, 6-7, 15-3, 6-4, 12-1, 5-5, X-1, Mo11-1, Mo19-2, Mo1-2, Mo7-1, Mo1-1, Mo3-2, Mo8-1, Mo2-1, Mo11-2, Mo17-2, Mo13-1, D8S1106 and D4S2408. A set of oligonucleotide primer pairs are provided. Each oligonucleotide primer pair flanks a single locus in the set of STR marker loci, which are co-amplified in a multiplex amplification reaction, with the product(s) comprising a mixture of amplified alleles from each of the co-amplified loci in the set of STR marker loci. The products are evaluated to determine the alleles present at each of the loci analyzed.
FILED	Monday, December 19, 2016
APPL NO	15/383378
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/156 (20130101)
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10746844 — Low-power, long-range RF localization system and method

US 10746844	Chuo et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Li-Xuan Chuo (Ann Arbor, Michigan); Hun-Seok Kim (Ann Arbor, Michigan); David T. Blaauw (Ann Arbor, Michigan); Dennis Sylvester (Ann Arbor, Michigan); Mingyu Yang (Ann Arbor, Michigan)
ABSTRACT	A system is presented for non-line-of-sight localization between RF enabled devices. A transmitting node is configured to transmit an RF ranging signal at a first carrier frequency, where the RF ranging signal is modulated with a symbol. The reflecting node is configured to receive the RF ranging signal and further operates to convert the RF ranging signal to a second carrier frequency and retransmit the converted ranging signal while simultaneously receiving the RF ranging signal. The localizing node is configured to receive the converted ranging signal from the reflecting node. The localizing node operates to identify, in frequency domain, the symbol in the converted ranging signal and compute a distance between the reflecting node and the localizing node based in part on the identified symbol in the converted ranging signal. The transmitting node and the localizing node may be on the same or different devices.
FILED	Wednesday, October 16, 2019
APPL NO	16/654547
ART UNIT	2643 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0226 (20130101) G01S 5/0273 (20130101) Original (OR) Class G01S 11/08 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/143 (20130101) H04L 27/2627 (20130101) Wireless Communication Networks H04W 64/006 (20130101)
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Department of Veterans Affairs (DVA)

10744218 — Holder for disinfection of tonometer tips or the like and method of use

US 10744218	Stein et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	United States Government as Represented by The Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Richard A. Stein (Leawood, Kansas); Kelly R. Foudray (Leavenworth, Kansas)
ABSTRACT	A holder device for holding a plurality of tonometer tips or the like during a disinfection procedure has a top wall, spaced rims extending downward from the top wall to engage a support surface and hold the top wall above the support surface, and handle portions extending upwards from the top wall. The top wall has a plurality of spaced holes of predetermined diameter each configured to hold a tip extending partially through the hole with a lower end of the tip spaced above a support surface. A cover plate is releasably secured between the handle portions at a location spaced above the top wall after loading the holes with tips, and holds the tips in the holes while at least a major portion of the device is submerged in a bath of disinfectant.
FILED	Friday, December 18, 2015
APPL NO	15/538844
ART UNIT	1796 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/16 (20130101) A61B 50/00 (20160201) A61B 50/20 (20160201) A61B 50/22 (20160201) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/18 (20130101) A61L 2/26 (20130101) Original (OR) Class Cleaning in General; Prevention of Fouling in General B08B 3/045 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10744362 — Exercise machine

US 10744362	Goldish et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)	United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Gary Goldish (Minneapolis, Minnesota); Andrew Hansen (Minneapolis, Minnesota); Eric Nickel (Minneapolis, Minnesota); John Ferguson (Minneapolis, Minnesota); Stuart Fairhurst (Minneapolis, Minnesota)
ABSTRACT	An exercise machine has a mobile base and an upright support extending upwards from the mobile base. An upper support assembly extends forward from an upper portion of the upright support and an exercise device is suspended from the upper support assembly at a location spaced forward from the upright support. The exercise machine may include a compact and safe counterbalancing gas spring mechanism that tends to move the exercise device away from the exerciser, and that requires a force to be applied to move an exercise device down towards the exerciser. The exercise machine may include an exercise device that is rotatable along a vertical axis, and may be coupled to an adjustable monitor for a wide range of uses. The exercise machine may be used by a exerciser lying supine, sitting in a chair or wheelchair, or standing in front of or adjacent the exercise machine.
FILED	Friday, June 29, 2018
APPL NO	16/024470
ART UNIT	3784 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0214 (20130101) A61H 1/0274 (20130101) A61H 3/008 (20130101) A61H 2201/0142 (20130101) A61H 2201/0157 (20130101) A61H 2201/1215 (20130101) A61H 2201/1635 (20130101) A61H 2203/0406 (20130101) A61H 2203/0456 (20130101) Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 21/005 (20130101) A63B 21/16 (20130101) A63B 21/0058 (20130101) A63B 21/00072 (20130101) Original (OR) Class A63B 21/0083 (20130101) A63B 21/0087 (20130101) A63B 21/225 (20130101) A63B 21/0552 (20130101) A63B 21/0628 (20151001) A63B 21/1672 (20151001) A63B 22/0005 (20151001) A63B 22/0007 (20130101) A63B 22/0046 (20130101) A63B 22/0076 (20130101) A63B 22/0605 (20130101) A63B 22/0694 (20130101) A63B 23/02 (20130101) A63B 23/1209 (20130101) A63B 23/1281 (20130101) A63B 71/0009 (20130101) A63B 71/023 (20130101) A63B 71/0036 (20130101) A63B 71/0054 (20130101) A63B 71/0619 (20130101) A63B 71/0622 (20130101) A63B 2022/0084 (20130101) A63B 2022/0647 (20130101) A63B 2071/025 (20130101) A63B 2071/0658 (20130101) A63B 2208/0204 (20130101) A63B 2208/0233 (20130101) A63B 2208/0252 (20130101) A63B 2210/04 (20130101) A63B 2225/09 (20130101) A63B 2225/093 (20130101) Vehicle Wheels; Castors; Axles for Wheels or Castors; Increasing Wheel Adhesion B60B 33/0081 (20130101) B60B 33/0089 (20130101) B60B 33/0092 (20130101) Vehicle Brake Control Systems or Parts Thereof; Brake Control Systems or Parts Thereof, in General; Arrangement of Braking Elements on Vehicles in General; Portable Devices for Preventing Unwanted Movement of Vehicles; Vehicle Modifications to Facilitate Cooling of Brakes B60T 1/04 (20130101) B60T 1/14 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

United States Postal Service (USPS)

10745224 — System and method of article feeder operation

US 10745224	Brown et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	John W. Brown (Manassas, Virginia); Edward F. Houston (Bristow, Virginia); Juan A. Roman (Fairfax, Virginia); Leung M. Shiu (Gaithersburg, Maryland); Riley H. Mayhall (Germantown, Maryland); Thomas A. Hillerich, Jr. (Louisville, Kentucky); Jacob L. Timm (Pasadena, Maryland); Matthew G. Good (Eldersburg, Maryland); William P. McConnell (Woodstock, Maryland); Robert L. Schlender (Columbia, Maryland); Christopher D. Austin (Parkville, Maryland)
ABSTRACT	Embodiments of a system and method for shingulating, singulating, and synchronizing articles in an article feeder system are disclosed. The article feeder system may include a shingulating device configured to receive a stack of articles and to produce a positively lapped stack of articles, a plurality of picking devices configured to pick one or more articles from the positively lapped stack of articles and to produce one or more singulated articles, and one or more synchronization devices configured to deliver the one or more singulated articles to one or more sorter windows.
FILED	Thursday, August 15, 2019
APPL NO	16/542172
ART UNIT	3656 — Material and Article Handling
CURRENT CPC	Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 47/06 (20130101) B65G 47/28 (20130101) B65G 47/46 (20130101) B65G 59/04 (20130101) Handling Thin or Filamentary Material, e.g Sheets, Webs, Cables B65H 3/46 (20130101) B65H 3/124 (20130101) Original (OR) Class B65H 5/24 (20130101) B65H 5/224 (20130101) B65H 7/12 (20130101) B65H 2220/09 (20130101) B65H 2220/09 (20130101) B65H 2301/321 (20130101) B65H 2404/2691 (20130101) B65H 2406/32 (20130101) B65H 2406/32 (20130101) B65H 2701/1916 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10748113 — System and method for providing real-time tracking of items in a distribution network

US 10748113	Dearing et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	Stephen M. Dearing (Herndon, Virginia); Kuldip K. Goyal (Alexandria, Virginia); Carla F. Sherry (Annandale, Virginia); Amy B. Cradic (Reston, Virginia); C. Scot Atkins (Chantilly, Virginia); Himesh A. Patel (Centerville, Virginia)
ABSTRACT	Systems and methods of processing items. Items in a distribution network or process may be scanned at every handling point in the distribution network, and each scan is recorded in a central repository. The scan information can be used to generate real-time access to data, analytical tools, predictive tools, and tracking reports.
FILED	Wednesday, October 18, 2017
APPL NO	15/787135
ART UNIT	2876 — Optics
CURRENT CPC	Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/18 (20130101) B07C 2301/0025 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/1417 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) G06Q 10/063 (20130101) G06Q 10/083 (20130101) G06Q 10/087 (20130101) Original (OR) Class G06Q 10/0833 (20130101) G06Q 30/0201 (20130101) G06Q 30/0241 (20130101) G06Q 50/28 (20130101) G06Q 50/32 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Transportation (USDOT)

10745320 — Compositions of matter comprising nanoparticles and non-conductive substrates

US 10745320	Thostenson
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) National Science Foundation (NSF) Department of Transportation (USDOT) Federal Highway Administration (FHWA) National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S)	University of Delaware (Newark, Delaware)
ASSIGNEE(S)	University of Delaware (Newark, Delaware)
INVENTOR(S)	Erik Thostenson (Newark, Delaware)
ABSTRACT	In various aspects, the processes disclosed herein may include the steps of inducing an electric field about a non-conductive substrate, and depositing functionalized nanoparticles upon the non-conductive substrate by contacting a nanoparticle dispersion with the non-conductive substrate, the nanoparticle dispersion comprising functionalized nanoparticles having an electrical charge, the electric field drawing the functionalized nanoparticles to the non-conductive substrate. In various aspects, the related composition of matter disclosed herein comprise functionalized nanoparticles bonded to a surface of a non-conductive fiber, the surface of the non-conductive fiber comprising a sizing adhered to the surface of the non-conductive fiber. This Abstract is presented to meet requirements of 37 C.F.R. § 1.72(b) only. This Abstract is not intended to identify key elements of the processes, and related apparatus and compositions of matter disclosed herein or to delineate the scope thereof.
FILED	Wednesday, August 09, 2017
APPL NO	15/672931
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/44 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) C08K 3/042 (20170501) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/4419 (20130101) C09D 7/61 (20180101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) C25D 13/12 (20130101) C25D 13/22 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/254 (20150115)
VIEW PATENT	@ USPTO: Full Text PDF

Environmental Protection Agency (EPA)

10745294 — Graphene oxide/magnesium oxide nanocomposites as superior sorbents for methylene blue removal from aqueous solutions

US 10745294	Heidarizad et al.
FUNDED BY	Environmental Protection Agency (EPA)
APPLICANT(S)	Southern Methodist University (Dallas, Texas)
ASSIGNEE(S)	SOUTHERN METHODIST UNIVERSITY (Dallas, Texas)
INVENTOR(S)	Mahdi Heidarizad (Dallas, Texas); S. Sevinç Sengör (Dallas, Texas)
ABSTRACT	The present invention includes a composition, method of making and method of using a composite for the removal of waste from a wastewater or a waste stream wherein the composite comprises of graphene oxide and magnesium oxide nanoparticles at a ratio of 10:1 to 1:10 weight to weight.
FILED	Thursday, June 22, 2017
APPL NO	15/630652
ART UNIT	1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/041 (20130101) B01J 20/205 (20130101) B01J 20/324 (20130101) B01J 20/3204 (20130101) B01J 20/3236 (20130101) B01J 20/28007 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/288 (20130101) Original (OR) Class C02F 2101/308 (20130101) C02F 2303/16 (20130101) C02F 2305/08 (20130101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 10/37 (20150501)
VIEW PATENT	@ USPTO: Full Text PDF

Office of the Director of National Intelligence (ODNI)

10748957 — Method of manufacturing a curved semiconductor die

US 10748957	McKnight et al.
FUNDED BY	Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	HRL LABORATORIES, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Geoffrey P. McKnight (Los Angeles, California); Andrew C. Keefe (Encino, California); Alexander R. Gurga (Canoga Park, California); Ryan Freeman (Los Angeles, California)
ABSTRACT	A method of manufacturing a curved semiconductor die includes: designing a semiconductor die design by conducting finite element analysis of an initial semiconductor die design having a partial spherical curvature, the initial semiconductor die design including a shape of a semiconductor die and a location and shape of a slit in the semiconductor die; when a size of a gap at the slit in the curved semiconductor die is outside a tolerance, modifying the initial semiconductor die design to provide a revised semiconductor die design and conducting another finite element analysis thereof; when the size of the gap at the slit in the curved semiconductor die is within the tolerance, manufacturing a microfabrication mask utilizing the initial semiconductor die design or the revised semiconductor die design having the size of the gap within the tolerance; forming a semiconductor die by utilizing the microfabrication mask; and curving the semiconductor die.
FILED	Thursday, April 18, 2019
APPL NO	16/388037
ART UNIT	2816 — Semiconductors/Memory
CURRENT CPC	Electric Digital Data Processing G06F 30/23 (20200101) G06F 2111/10 (20200101) G06F 2119/18 (20200101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14683 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Small Business Administration (SBA)

10748410 — System and method for detecting hand hygiene compliance

US 10748410	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Nursing Research (NINR) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Microsensor Labs, LLC (Chicago, Illinois)
ASSIGNEE(S)	Microsensor Labs, LLC (Chicago, Illinois)
INVENTOR(S)	Peng Liu (Chicago, Illinois); Yang Liu (Beijing, China PRC); Jiapeng Huang (Louisville, Kentucky)
ABSTRACT	A system and method for detecting hand hygiene compliance is disclosed. Hand hygiene is important in various contexts, including hospital settings, home settings, work settings, and school settings. For example, a healthcare provider may wear a wristband, which may interact with a stationary controller that is integrated with or proximate to a hand cleaning agent dispenser. The interaction may be used to determine whether the healthcare provider has complied with hand hygiene protocols. Further, the wristband may be used to train healthcare providers or others (such as children) in proper hand hygiene. Further, the wristband may be used in other contexts, such as integrating hand hygiene monitoring and access control. Also, monitoring people when performing tasks, such as hygiene tasks, cooking, and moving about, may be beneficial to those with cognitive difficulties, such as dementia. A device for detecting the tasks being performed and providing reminders to the people regarding the tasks may help those with dementia.
FILED	Friday, August 30, 2019
APPL NO	16/557191
ART UNIT	2685 — Selective Communication
CURRENT CPC	Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 1/00 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/18 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10366 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/245 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/20 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

U.S. Agency for International Development (USAID)

10746464 — Modular collapsible solar dryer for multipurpose drying

US 10746464	Ileleji et al.
FUNDED BY	U.S. Agency for International Development (USAID)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
INVENTOR(S)	Klein Erhekabor Ileleji (Carmel, Indiana); Jesumayomikun Adegoke Olasubulumi (Lafayette, Indiana); Diana Milena Ramirez Gutierrez (Bogota, Colombia)
ABSTRACT	A solar dryer system, including an upper thermal collection unit including a plurality of tiers of thermal radiation collection panels, where a vent is disposed between adjacent ones of the tiers of the thermal radiation collection panels. The solar dryer system can include a chamber disposed between the upper thermal collection unit and a base, where the chamber is configured to receive an object for a drying process using the dryer system. The solar dryer system can also include at least one fan disposed within the chamber and coupled to the base to provide circulation for the drying process.
FILED	Friday, August 12, 2016
APPL NO	15/751241
ART UNIT	3762 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Machines or Apparatus for Treating Harvested Fruit, Vegetables or Flower Bulbs in Bulk, Not Otherwise Provided For; Peeling Vegetables or Fruit in Bulk; Apparatus for Preparing Animal Feeding- Stuffs A23N 12/08 (20130101) Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 3/28 (20130101) Original (OR) Class F26B 9/003 (20130101) F26B 9/06 (20130101) F26B 21/08 (20130101) F26B 21/10 (20130101) F26B 25/06 (20130101) F26B 25/14 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10749096 — Controlling a state of a qubit assembly via tunable coupling

US 10749096	Przybysz et al.
FUNDED BY
APPLICANT(S)	Anthony Joseph Przybysz (Linthicum, Maryland); Joel D. Strand (Ellicott City, Maryland)
ASSIGNEE(S)	NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia)
INVENTOR(S)	Anthony Joseph Przybysz (Linthicum, Maryland); Joel D. Strand (Ellicott City, Maryland)
ABSTRACT	Methods and apparatuses are provided for controlling the state of a qubit. A qubit apparatus includes a load, a qubit, and a compound Josephson junction coupler coupling the qubit to the load. A coupling controller controls the coupling strength of the compound Josephson junction coupler such that a coupling between the qubit and the load is a first value when a reset of the qubit is desired and a second value during operation of the qubit.
FILED	Thursday, February 01, 2018
APPL NO	15/886602
ART UNIT	2895 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/045 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

10749193 — Oxygen regulated fuel cell with valve

US 10749193	Eickhoff et al.
FUNDED BY
APPLICANT(S)	Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	Honeywell International Inc. (Morris Plains, New Jersey)
INVENTOR(S)	Steven J. Eickhoff (Brooklyn Park, Minnesota); Jeffrey Michael Klein (Minneapolis, Minnesota); Jason Wiebesick (Golden Valley, Minnesota)
ABSTRACT	A device includes a container having a top plate containing an array of oxygen limiting pinholes and a chamber to hold a chemical hydride fuel, a fuel cell membrane electrode assembly supported within the container between the top plate and the chamber positioned to receive oxygen from the pinholes and hydrogen from the chamber, and a valve assembly positioned to regulate additional flow of oxygen to the fuel cell proton exchange membrane electrode assembly responsive to hydrogen pressure in the chamber.
FILED	Thursday, September 17, 2015
APPL NO	14/857629
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 3/065 (20130101) C01B 2203/066 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/065 (20130101) H01M 8/1004 (20130101) H01M 8/1007 (20160201) H01M 8/04104 (20130101) Original (OR) Class H01M 8/04388 (20130101) H01M 8/04753 (20130101) H01M 2008/1095 (20130101) H01M 2250/30 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 90/18 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/362 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, August 18, 2020.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2020/fedinvent-patents-20200818.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

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