FedInvent™ Patents
Patent Details for Tuesday, September 01, 2020
This page was updated on Monday, March 27, 2023 at 06:10 AM GMT
Department of Health and Human Services (HHS)
| US 10758170 | Vaillancourt |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| INVENTOR(S) | David E. Vaillancourt (Gainesville, Florida) |
| ABSTRACT | A treatment efficacy of a treatment for treating a parkinsonian disease is determined. A first set of imaging information/data associated with a dMRI scan of an individual's brain captured at a first time and a second set of imaging information/data associated with a dMRI scan of the individual's brain captured at a second time are received. The individual underwent the treatment for a time period comprising at least part of the time between the first and second times. An expected change between the first and second times is determined based on a natural progression of the parkinsonian disease. The first and second sets of imaging information/data are analyzed to determine a first free-water pattern and a second free-water pattern. Based on the first and second free-water patterns, a disease progression score is determined. Based on the disease progression score and the expected change, a treatment efficacy for treating the individual with the treatment is determined. |
| FILED | Tuesday, March 20, 2018 |
| APPL NO | 16/500185 |
| ART UNIT | 2663 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4082 (20130101) Original (OR) Class A61B 5/4848 (20130101) A61B 2576/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758175 | Grossman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); NuVu LLC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); NuVu LLC (Cambridge, Massachusetts) |
| INVENTOR(S) | Nir Grossman (Lorrach, Germany); David Wang (Cambridge, Massachusetts); Edward Boyden (Chestnut Hill, Massachusetts) |
| ABSTRACT | A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform. |
| FILED | Monday, September 16, 2019 |
| APPL NO | 16/571845 |
| ART UNIT | 3715 — Amusement and Education Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0476 (20130101) A61B 5/1101 (20130101) A61B 5/04001 (20130101) A61B 5/4836 (20130101) Original (OR) Class A61B 5/7253 (20130101) A61B 5/7257 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0622 (20130101) A61N 7/00 (20130101) A61N 2005/063 (20130101) A61N 2007/0021 (20130101) Electric Digital Data Processing G06F 17/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758209 | Boctor et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Emad M. Boctor (Baltimore, Maryland); Russell H. Taylor (Severna Park, Maryland); Jin U. Kang (Ellicott City, Maryland) |
| ABSTRACT | An intraoperative registration and tracking system includes an optical source configured to illuminate tissue intraoperatively with electromagnetic radiation at a substantially localized spot so as to provide a photoacoustic source at the substantially localize spot, an optical imaging system configured to form an optical image of at least a portion of the tissue and to detect and determine a position of the substantially localized spot in the optical image, an ultrasound imaging system configured to form an ultrasound image of at least a portion of the tissue and to detect and determine a position of the substantially localized spot in the ultrasound image, and a registration system configured to determine a coordinate transformation that registers the optical image with the ultrasound image based at least partially on a correspondence of the spot in the optical image with the spot in the ultrasound image. |
| FILED | Monday, March 11, 2013 |
| APPL NO | 14/381374 |
| ART UNIT | 3799 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0084 (20130101) A61B 5/0095 (20130101) A61B 6/032 (20130101) A61B 6/5247 (20130101) A61B 8/14 (20130101) A61B 8/445 (20130101) A61B 8/483 (20130101) A61B 8/0841 (20130101) A61B 8/4254 (20130101) A61B 8/4416 (20130101) A61B 8/5261 (20130101) Original (OR) Class A61B 34/20 (20160201) A61B 90/37 (20160201) A61B 90/361 (20160201) A61B 2034/2063 (20160201) A61B 2034/2065 (20160201) A61B 2090/306 (20160201) A61B 2090/364 (20160201) A61B 2090/365 (20160201) A61B 2090/371 (20160201) A61B 2090/373 (20160201) A61B 2090/378 (20160201) A61B 2090/3937 (20160201) A61B 2090/3945 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758264 | Bankiewicz |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Krystof Bankiewicz (Oakland, California) |
| ABSTRACT | The use of stepped cannulas, wherein a step structure creates a backstop to reduce backflow along the cannula body, is known for convection enhanced delivery of agents to the brain and other structures within an animal. Described herein are novel and improved stepped cannula designs wherein the length of the cannula segment between the step and the dispensing outlet is variable and can be controllably adjusted inside the patient during delivery. This advantageously allows the operator to place the cannula step at the optimal position and deliver agents at one or more positions within the target structure. |
| FILED | Thursday, November 12, 2015 |
| APPL NO | 15/525548 |
| ART UNIT | 3783 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/12 (20130101) A61B 17/3417 (20130101) A61B 17/3421 (20130101) Original (OR) Class A61B 17/3478 (20130101) A61B 2017/00991 (20130101) A61B 2017/3433 (20130101) A61B 2017/3443 (20130101) A61B 2017/3454 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/46 (20130101) A61M 5/158 (20130101) A61M 5/3286 (20130101) A61M 2206/20 (20130101) A61M 2210/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758347 | Kheradvar et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Arash Kheradvar (Irvine, California); Gregory S Kelley (Santee, California) |
| ABSTRACT | Described is a delivery system for percutaneous delivery and implantation of a heart valve. The delivery system includes a handle with a sheath extending therefrom. A splay shaft extends from the handle through the sheath. At least two arms extend from the handle through the splay shaft. The at least two arms are operable for holding a heart valve. A sheath controller is housed within the handle and is operable for selectively advancing or retracting the sheath to constrain or expose a heart valve as attached with the at least two arms. A splay shaft controller is housed within the handle for allowing the user to selectively advance or retract the splay shaft to constrain or expose the at least two arms. Finally, a valve release is attached with the handle to allow a user to selectively release a heart valve as attached with the at least two arms. |
| FILED | Monday, June 19, 2017 |
| APPL NO | 15/627360 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 2017/00292 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/243 (20130101) Original (OR) Class A61F 2/2436 (20130101) A61F 2/2439 (20130101) A61F 2/9517 (20200501) A61F 9/0026 (20130101) A61F 2002/9511 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758403 | Chin et al. |
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| FUNDED BY |
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| APPLICANT(S) | HydroGlyde Coatings LLC (Brookline, Massachusetts) |
| ASSIGNEE(S) | HydroGlyde Coatings LLC (Brookline, Massachusetts) |
| INVENTOR(S) | Stacy Lee Chin (Brookline, Massachusetts); Benjamin Goldman Cooper (Lynnfield, Massachusetts); Ruiqing Xiao (Boston, Massachusetts); Mark W. Grinstaff (Brookline, Massachusetts) |
| ABSTRACT | The invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity. |
| FILED | Monday, September 09, 2019 |
| APPL NO | 16/564717 |
| ART UNIT | 1762 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 6/04 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 41/22 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/26 (20130101) B32B 27/28 (20130101) B32B 27/30 (20130101) B32B 27/36 (20130101) B32B 27/285 (20130101) B32B 27/302 (20130101) B32B 27/306 (20130101) B32B 2307/728 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 7/042 (20130101) C08J 2300/26 (20130101) C08J 2307/00 (20130101) C08J 2307/02 (20130101) C08J 2347/00 (20130101) C08J 2407/02 (20130101) C08J 2409/02 (20130101) Compositions of Macromolecular Compounds C08L 7/02 (20130101) C08L 9/08 (20130101) C08L 11/02 (20130101) C08L 29/04 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 107/02 (20130101) C09D 109/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758408 | Passaglia et al. |
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| FUNDED BY |
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| APPLICANT(S) | Christopher Lawrence Passaglia (Lutz, Florida); Sharad Suryakant Malavade (Brandon, Florida) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | Christopher Lawrence Passaglia (Lutz, Florida); Sharad Suryakant Malavade (Brandon, Florida) |
| ABSTRACT | A tethered cannula having at least two curved sections for implantation into an eye and a method for implanting the cannula in the eye. The cannula can withstand ever present and changing rotational forces from eye movement and mechanical forces from the movement of the subject. The cannula can be connected to implantable or tetherable devices that are too large, heavy, or obstructive to attach directly to the eye, such as an intraocular pressure sensor or infusion pump. |
| FILED | Friday, October 13, 2017 |
| APPL NO | 15/783458 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/16 (20130101) A61B 17/34 (20130101) A61B 2017/3458 (20130101) A61B 2017/3482 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0017 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758459 | Deng et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| INVENTOR(S) | Yang Deng (New Haven, Connecticut); Asiri Ediriwickrema (Cary, North Carolina); William M. Saltzman (New Haven, Connecticut) |
| ABSTRACT | Core-shell particles have a hydrophobic core and a shell formed of or containing hyperbranched polyglycerol (HPG). The HPG can be covalently bound to the one or more materials that form the core or coated thereon. The HPG coating can be modified to adjust the properties of the particles. For example, unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups on tissue or otherwise interact with tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HPG coated nanoparticles. In some embodiments, the particles include therapeutic, diagnostic, nutraceutical, and/or prophylactic agents such as those used as sunblock compositions. |
| FILED | Tuesday, April 09, 2019 |
| APPL NO | 16/379224 |
| ART UNIT | 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/90 (20130101) A61K 8/0241 (20130101) Original (OR) Class A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 9/1647 (20130101) A61K 9/5031 (20130101) A61K 9/5146 (20130101) A61K 9/5153 (20130101) A61K 31/427 (20130101) A61K 31/4178 (20130101) A61K 31/4745 (20130101) A61K 47/34 (20130101) A61K 2800/412 (20130101) A61K 2800/413 (20130101) A61K 2800/624 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101) Acyclic or Carbocyclic Compounds C07C 59/06 (20130101) C07C 59/08 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 83/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758511 | Connor et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Kip M. Connor (Newton, Massachusetts); Eiichi Hasegawa (Fukuoka, Japan); Bruce D. Hammock (Davis, California); Kin Sing Stephen Lee (Davis, California) |
| ABSTRACT | This disclosure relates to methods of reducing inflammation, angiogenesis, vascular leakage and neovascularization by administering to a subject in need thereof one or more stable analogs of CYP450 lipid metabolites (e.g., eicosanoids) and one or more inhibitors of a soluble epoxide hydrolase (sEH). This disclosure also relates to methods of treating disorders associated with inflammation, angiogenesis, vascular leakage and neovascularization by administering to a subject in need thereof one or more stable analogs of CYP450 lipid metabolites (e.g., eicosanoids) and one or more inhibitors of a soluble epoxide hydrolase (sEH). This disclosure further relates to pharmaceutical compositions and kits comprising at least one stable analog of CYP450 lipid metabolites (e.g., eicosanoids) and at least one inhibitor of a soluble epoxide hydrolase (sEH). |
| FILED | Thursday, November 17, 2016 |
| APPL NO | 15/777141 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 31/17 (20130101) A61K 31/17 (20130101) A61K 31/202 (20130101) A61K 31/202 (20130101) A61K 31/336 (20130101) Original (OR) Class A61K 31/336 (20130101) A61K 31/445 (20130101) A61K 31/445 (20130101) A61K 31/4468 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 27/04 (20180101) A61P 27/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758513 | Koehler et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Carla M. Koehler (Los Angeles, California); Samuel A. Hasson (Portland, Oregon); Kiyoko Miyata (Los Angeles, California); Michael A. Teitell (Tarzana, California); Deepa Dabir (Redondo Beach, California) |
| ABSTRACT | The present invention provides compounds that modulate protein translocation in mitochondria, compositions thereof, and methods of identifying, making and using these. |
| FILED | Thursday, November 16, 2017 |
| APPL NO | 15/815565 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/15 (20130101) A61K 31/137 (20130101) A61K 31/343 (20130101) Original (OR) Class A61K 31/404 (20130101) A61K 31/4196 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) C12Q 1/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5079 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758516 | Jiang |
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| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Jianxiong Jiang (Blue Ash, Ohio) |
| ABSTRACT | Pharmaceutical compositions of selective EP2 antagonists exemplified by small molecules TG4-155 and TG6-10-1 effective for treating gliomas, and methods for administering the pharmaceutical compositions to treat subjects suffering from disorders characterized by gliomagenesis. |
| FILED | Wednesday, August 22, 2018 |
| APPL NO | 16/108121 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/4045 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758524 | Zheng et al. |
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| FUNDED BY |
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| APPLICANT(S) | BioVentures, LLC (Little Rock, Arkansas) |
| ASSIGNEE(S) | BioVentures, LLC (Little Rock, Arkansas) |
| INVENTOR(S) | Guangrong Zheng (Little Rock, Arkansas); Daohong Zhou (Little Rock, Arkansas); Xingui Liu (Little Rock, Arkansas); Yingying Wang (Little Rock, Arkansas); Jianhui Chang (Little Rock, Arkansas); Wei Feng (Little Rock, Arkansas); Lijian Shao (Little Rock, Arkansas); Yi Luo (Little Rock, Arkansas) |
| ABSTRACT | The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine (PL) or derivative thereof. The selective killing of senescent cells may delay aging and/or treat age-related disorders. |
| FILED | Tuesday, August 07, 2018 |
| APPL NO | 16/057021 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/10 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2002/00 (20130101) A23V 2200/302 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/45 (20130101) Original (OR) Class A61K 31/45 (20130101) A61K 31/55 (20130101) A61K 31/55 (20130101) A61K 31/443 (20130101) A61K 31/443 (20130101) A61K 31/444 (20130101) A61K 31/444 (20130101) A61K 31/635 (20130101) A61K 31/635 (20130101) A61K 31/4015 (20130101) A61K 31/4015 (20130101) A61K 31/4412 (20130101) A61K 31/4412 (20130101) A61K 31/4439 (20130101) A61K 31/4439 (20130101) A61K 31/4545 (20130101) A61K 31/4545 (20130101) A61K 31/5377 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 207/38 (20130101) C07D 211/76 (20130101) C07D 211/88 (20130101) C07D 211/96 (20130101) C07D 223/10 (20130101) C07D 401/06 (20130101) C07D 405/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758526 | Saha et al. |
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| FUNDED BY |
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| APPLICANT(S) | BIOMED VALLEY DISCOVERIES, INC. (Kansas City, Missouri); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH (Bethesda, Maryland); Biomed Valley Discoveries, Inc. (Kansas City, Missouri) |
| INVENTOR(S) | Saurabh Saha (Wellesley Hills, Massachusetts); Xiaoyan M. Zhang (Lexington, Massachusetts); Dimiter Dimitrov (Frederick, Maryland); Zhongyu Zhu (Frederick, Maryland); Brad St. Croix (Frederick, Maryland); Enrique Zudaire (Germantown, Maryland) |
| ABSTRACT | The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a molecularly targeted agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein. |
| FILED | Tuesday, June 09, 2015 |
| APPL NO | 15/317079 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4745 (20130101) Original (OR) Class A61K 39/39558 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6851 (20170801) A61K 47/6855 (20170801) A61K 47/6865 (20170801) A61K 47/6869 (20170801) A61K 2039/505 (20130101) A61K 2039/507 (20130101) A61K 2039/545 (20130101) A61K 2300/00 (20130101) Peptides C07K 16/28 (20130101) C07K 2317/21 (20130101) C07K 2317/56 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
10758537 — Carbonic anhydrase enzymes for regulating mast cell hematopoiesis and type 2 inflammation
| US 10758537 | Siracusa |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Mark C. Siracusa (New Brunswick, New Jersey) |
| ABSTRACT | The invention provides methods and compositions that are useful for treating allergic diseases, bacterial infections, fungal infections, viral infections, mastocytosis, mast cell-mediated inflammation and parasite infections (e.g., helminth infections). |
| FILED | Friday, August 12, 2016 |
| APPL NO | 15/764785 |
| ART UNIT | 1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/18 (20130101) A61K 31/423 (20130101) A61K 31/423 (20130101) A61K 31/433 (20130101) A61K 31/433 (20130101) A61K 31/451 (20130101) A61K 31/451 (20130101) A61K 31/505 (20130101) A61K 31/505 (20130101) A61K 31/513 (20130101) Original (OR) Class A61K 31/513 (20130101) A61K 31/542 (20130101) A61K 31/542 (20130101) A61K 31/4184 (20130101) A61K 31/4184 (20130101) A61K 31/7048 (20130101) A61K 31/7048 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
10758538 — Heat shock protein binding compounds, compositions, and methods for making and using same
| US 10758538 | Chiosis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan-Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Gabriela Chiosis (New York, New York); Tony Taldone (Forest Hills, New York); Anna Rodina (New York, New York); Pallav Patel (Fresh Meadows, New York); Yanlong Kang (Plainsboro, New Jersey) |
| ABSTRACT | The present subject matter relates to a compound represented by the general formula (I) or (I′) or a pharmacologically acceptable salt thereof; pharmaceutical compositions containing at least one of these compounds; methods of making at least one of these compounds; methods of using at least one of these compounds for treating and/or preventing various cancers and/or proliferation disorders; methods of using at least one of these compounds for monitoring the effectiveness of an anticancer therapy against various cancers. In one embodiment, the subject matter relates to compounds that bind with a level of specificity to heat shock protein 70 (Hsp70). In another embodiment, the subject matter relates to compounds that bind with a level of specificity to inhibit both heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70). |
| FILED | Tuesday, July 17, 2018 |
| APPL NO | 16/037160 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/513 (20130101) Original (OR) Class A61K 2121/00 (20130101) Heterocyclic Compounds C07D 239/38 (20130101) C07D 239/47 (20130101) C07D 239/56 (20130101) C07D 239/60 (20130101) C07D 403/12 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758545 | Ichida et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Justin Ichida (Los Angeles, California); Shaoyu Lin (Monterey Park, California); Yichen Li (Oxford, United Kingdom); Yingxiao Shi (Los Angeles, California) |
| ABSTRACT | Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered C9ORF72 protein activity. In one aspect, the method includes a step of administering an effective dose of a pharmaceutical composition to a subject in need thereof, thereby rescuing the defects associated with altered C9ORF72 protein activity. Also described are methods for identifying a compound for inhibiting motor neuron degeneration. |
| FILED | Friday, June 24, 2016 |
| APPL NO | 15/579546 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/5377 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758559 | Nair |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Wyoming (Laramie, Wyoming) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming) |
| INVENTOR(S) | Sreejayan Nair (Laramie, Wyoming) |
| ABSTRACT | Diabetic wounds have elevated levels of cathepsin K, a protease enzyme, which degrades proteins, such as collagen, causing delayed wound healing. By targeting cathepsin K, diabetic wound healing is ameliorated. Methods and devices for treatment include topical application of pharmacological inhibitors of cathepsin K, for example, in the form of gel, powder, or bandage. Other methods and systems include localized genetic knock out of the cathepsin K gene by topical application of a small interfering RNA (siRNA) or antisense oligonucleotide to aid in wound healing. |
| FILED | Tuesday, September 04, 2018 |
| APPL NO | 16/121443 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/7105 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 26/0009 (20130101) A61L 26/0061 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758588 | Davisson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Vincent Jo Davisson (West Lafayette, Indiana); Matthew David Bartolowits (West Lafayette, Indiana); Jonathon Michael Gast (Lafayette, Indiana) |
| ABSTRACT | The present invention relates to series of compounds as an inhibitor targeting Proliferating Cell Nuclear Antigen (PCNA). Pharmaceutical compositions of those compounds and methods of using them in the treatment of cancer are within the scope of this disclosure. |
| FILED | Tuesday, December 06, 2016 |
| APPL NO | 15/781742 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/06 (20130101) Original (OR) Class A61K 45/06 (20130101) Peptides C07K 5/08 (20130101) C07K 5/0806 (20130101) C07K 5/0812 (20130101) C07K 5/06086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758591 | Frisbee et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Alyse Longtin Frisbee (Charlottesville, Virginia); William A. Petri, Jr. (Charlottesville, Virginia) |
| ABSTRACT | Clostridium difficile infection is the leading cause of hospital acquired antibiotic-associated diarrhea in the US (Bartlett, in 2006). The increased prevalence of circulating C. difficile strains poses a significant health threat to US health care facilities. Strains expressing the toxin C. difficile Transferase (CDT), in addition to Toxins A and B (TcdA and TcdB), are more virulent and are associated with higher mortality rates (Bacci et al., 2011). We recently identified a protective role for eosinophils against C. difficile pathogenesis (Buonomo et al., 2016). We have also defined CDT's ability to increase host inflammation and suppress protective eosinophils through a TLR2 dependent mechanism (Cowardin et al., 2016). How CDT promotes virulence and eosinophil suppression via TLR2 is still under investigation. We employed a genome-wide microarray approach to reveal divergent transcriptional profiles between protected (TLR2−/−) and unprotected (WT) mice infected with either CDT expressing or CDT mutant strains of C. difficile. This work revealed novel host mediated TLR2-dependent inflammatory pathways to CDT. We provide an unbiased framework for understanding the host immune response to the binary toxin CDT produced by C. difficile and how TLR2 signaling enhances virulence. |
| FILED | Tuesday, July 25, 2017 |
| APPL NO | 16/317887 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 31/426 (20130101) A61K 31/437 (20130101) A61K 31/437 (20130101) A61K 31/4164 (20130101) A61K 31/4164 (20130101) A61K 31/7036 (20130101) A61K 31/7036 (20130101) A61K 31/7042 (20130101) A61K 31/7042 (20130101) A61K 31/7048 (20130101) A61K 31/7048 (20130101) A61K 38/00 (20130101) A61K 38/14 (20130101) A61K 38/14 (20130101) A61K 38/20 (20130101) Original (OR) Class A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/04 (20180101) A61P 31/04 (20180101) Peptides C07K 14/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758600 | Orbach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Marc J. Orbach (Tucson, Arizona); Lisa F. Shubitz (Tucson, Arizona); Hema P. Narra (Tucson, Arizona) |
| ABSTRACT | The present disclosure provides immunogenic materials and methods useful for reducing the risk of fungal infections, particularly valley fever. The disclosure also provides assays for identifying compounds useful to treat valley fever, as well as methods for ameliorating the symptoms of valley fever. |
| FILED | Thursday, August 22, 2019 |
| APPL NO | 16/548438 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/30 (20200101) Preparations for Medical, Dental, or Toilet Purposes A61K 36/06 (20130101) A61K 39/0002 (20130101) Original (OR) Class A61K 2039/54 (20130101) A61K 2039/55 (20130101) A61K 2039/522 (20130101) A61K 2039/543 (20130101) A61K 2039/545 (20130101) A61K 2039/552 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758607 | Peeples et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Institute at Nationwide Children's Hospital (Columbus, Ohio) |
| ASSIGNEE(S) | The Research Institute at Nationwide Children's Hospital (Columbus, Ohio) |
| INVENTOR(S) | Mark Edward Peeples (Bexley, Ohio); Steven A. Kwilas (Fort Detrick, Maryland); Jacqueline Dianne Corry (Columbus, Ohio) |
| ABSTRACT | Embodiments disclosed herein provide compositions, methods, and uses for respiratory syncytial viruses (RSV) and immunogenic compositions thereof. Certain embodiments provide RSV having cleavage-resistant mutated attachment (G) glycoproteins. In some embodiments, the cleavage-resistant G protein mutants increase production of live attenuated RSV in host cells. Also provided are methods for amplifying RSV in host cells, wherein the amplified RSV has full length G protein. In certain embodiments, the amplified RSV having full length G protein is formulated into immunogenic compositions, including vaccines. Other embodiments provide methods for inducing an effective immune response against RSV infection in a subject. |
| FILED | Friday, June 17, 2016 |
| APPL NO | 15/737225 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/525 (20130101) A61K 2039/545 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18522 (20130101) C12N 2760/18534 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758609 | Yamamoto |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida) |
| INVENTOR(S) | Janet K. Yamamoto (Gainesville, Florida) |
| ABSTRACT | The subject invention concerns methods and materials for inducing an immune response in an animal or person against an immunodeficiency virus, such as HIV, SIV, or FIV. In one embodiment, a method of the invention comprises administering one or more antigens and/or immunogens to the person or animal wherein the antigen and/or immunogen comprises one or more evolutionarily conserved epitopes of immunodeficiency viruses. In one embodiment, the epitope is one that is conserved between HIV and FIV. |
| FILED | Sunday, September 25, 2016 |
| APPL NO | 15/762108 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/12 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 2039/54 (20130101) A61K 2039/545 (20130101) A61K 2039/552 (20130101) A61K 2039/572 (20130101) A61K 2039/575 (20130101) A61K 2039/645 (20130101) A61K 2039/5252 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/18 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/15034 (20130101) C12N 2740/15071 (20130101) C12N 2740/16134 (20130101) C12N 2740/16171 (20130101) C12N 2740/16234 (20130101) C12N 2740/16271 (20130101) C12N 2740/16334 (20130101) C12N 2740/16371 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758613 | Saha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BIOMED VALLEY DISCOVERIES, INC. (Kansas City, Missouri); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INTSTITUTES OF HEALTH (Bethesda, Maryland); BIOMED VALLEY DISCOVERIES, INC. (Kansas City, Missouri) |
| INVENTOR(S) | Saurabh Saha (Wellesley Hills, Massachusetts); Xiaoyan M. Zhang (Lexington, Massachusetts); Dimiter Dimitrov (Frederick, Maryland); Zhongyu Zhu (Frederick, Maryland); Brad St. Croix (Frederick, Maryland); Enrique Zudaire (Germantown, Maryland) |
| ABSTRACT | The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of an agent selected from an anti-metabolite agent or analog thereof and combinations thereof; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein. |
| FILED | Tuesday, June 09, 2015 |
| APPL NO | 15/317055 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/337 (20130101) A61K 31/513 (20130101) A61K 31/513 (20130101) A61K 31/4745 (20130101) A61K 31/4745 (20130101) A61K 31/7068 (20130101) A61K 31/7068 (20130101) A61K 33/24 (20130101) A61K 33/24 (20130101) A61K 39/395 (20130101) A61K 39/39558 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/6817 (20170801) A61K 47/6855 (20170801) A61K 47/6857 (20170801) A61K 47/6863 (20170801) A61K 47/6865 (20170801) A61K 47/6869 (20170801) A61K 2039/505 (20130101) A61K 2039/507 (20130101) A61K 2039/545 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 16/18 (20130101) C07K 16/22 (20130101) C07K 16/30 (20130101) C07K 2317/24 (20130101) C07K 2317/52 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/72 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758614 | Saha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BIOMED VALLEY DISCOVERIES, INC. (Kansas City, Missouri); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH (Bethesda, Maryland); Biomed Valley Discoveries, Inc. (Kansas City, Missouri) |
| INVENTOR(S) | Saurabh Saha (Wellesley Hills, Massachusetts); Xiaoyan M. Zhang (Lexington, Massachusetts); Dimiter Dimitrov (Frederick, Maryland); Zhongyu Zhu (Frederick, Maryland); Brad St. Croix (Frederick, Maryland); Enrique Zudaire (Germantown, Maryland) |
| ABSTRACT | The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a topoisomerase inhibitor; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein. |
| FILED | Tuesday, June 09, 2015 |
| APPL NO | 15/317086 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/337 (20130101) A61K 31/415 (20130101) A61K 31/415 (20130101) A61K 31/505 (20130101) A61K 31/505 (20130101) A61K 31/704 (20130101) A61K 31/704 (20130101) A61K 31/4745 (20130101) A61K 31/4745 (20130101) A61K 39/39558 (20130101) Original (OR) Class A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 47/6803 (20170801) A61K 47/6863 (20170801) A61K 2039/505 (20130101) A61K 2039/507 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 16/22 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/3015 (20130101) C07K 16/3023 (20130101) C07K 16/3046 (20130101) C07K 16/3053 (20130101) C07K 2317/24 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/72 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758627 | Wickline et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Samuel A. Wickline (St. Louis, Missouri); Kirk Hou (St. Louis, Missouri) |
| ABSTRACT | A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof. |
| FILED | Friday, July 01, 2016 |
| APPL NO | 15/738478 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 38/00 (20130101) A61K 47/6455 (20170801) Original (OR) Class Peptides C07K 7/08 (20130101) C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 2310/14 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758632 | Yazaki et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Paul Yazaki (Duarte, California); Jack Shively (Duarte, California); Michael Bouvet (La Jolla, California); Jonathan Delong (La Jolla, California); Yuman Fong (Duarte, California) |
| ABSTRACT | Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate. |
| FILED | Thursday, January 25, 2018 |
| APPL NO | 15/880454 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 6/037 (20130101) A61B 6/4057 (20130101) A61B 34/20 (20160201) A61B 2034/2055 (20160201) A61B 2505/05 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 49/0032 (20130101) A61K 49/0058 (20130101) Original (OR) Class A61K 51/1048 (20130101) A61K 51/1057 (20130101) A61K 51/1063 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/3007 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758633 | Wei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | He Wei (Cambridge, Massachusetts); Oliver T. Bruns (Boston, Massachusetts); Ou Chen (Mansfield, Massachusetts); Moungi G. Bawendi (Cambridge, Massachusetts) |
| ABSTRACT | A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging. |
| FILED | Monday, October 01, 2018 |
| APPL NO | 16/149082 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/1839 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758645 | McNamara et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tufts University (Medford, Massachusetts) |
| ASSIGNEE(S) | Tufts University (Medford, Massachusetts) |
| INVENTOR(S) | Stephanie L. McNamara (North Attleboro, Massachusetts); Benjamin P. Partlow (Winchester, Massachusetts); David L. Kaplan (Concord, Massachusetts) |
| ABSTRACT | The present invention provides, among other things, a silk ceramic material having enzymatically cross-linked amino acid side chains to generate injectable and flexible foam ceramics. Provided are compositions and methods of producing soft, flexible ceramic foam with silk polymeric crosslinking to serve as binders. Materials have applications in osteochondral and dental replacement and repair. |
| FILED | Thursday, December 17, 2015 |
| APPL NO | 15/536261 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/46 (20130101) Original (OR) Class A61L 27/46 (20130101) A61L 27/56 (20130101) A61L 27/227 (20130101) A61L 27/3821 (20130101) A61L 2400/06 (20130101) A61L 2430/02 (20130101) A61L 2430/12 (20130101) Peptides C07K 14/43586 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758738 | Chiel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Hillel Chiel (Cleveland, Ohio); Niloy Bhadra (Cleveland, Ohio); Mike Jenkins (Cleveland, Ohio); Emilie Lothet (Cleveland, Ohio); Tina Vrabec (Cleveland, Ohio); Kevin Kilgore (Cleveland, Ohio); Narendra Bhadra (Cleveland, Ohio); Eric Duco Jansen (Cleveland, Ohio) |
| ABSTRACT | One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal. |
| FILED | Tuesday, March 17, 2015 |
| APPL NO | 15/126610 |
| ART UNIT | 3737 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/007 (20130101) A61F 2007/0071 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/06 (20130101) A61N 1/28 (20130101) A61N 1/403 (20130101) Original (OR) Class A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 5/0622 (20130101) A61N 5/0625 (20130101) A61N 7/02 (20130101) A61N 2005/067 (20130101) A61N 2005/0659 (20130101) A61N 2007/0021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758895 | Zeng |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh Of The Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Dexing Zeng (Pittsburgh, Pennsylvania) |
| ABSTRACT | A Cu(I)-Catalyzed Azide-Alkyne Cycloadditions (CuAAC) ligand comprising: a catalytic core; a fluorous tag; and a linker binding the fluorous tag to the catalytic core. A method for carrying out a Cu(I)-Catalyzed Azide-Alkyne Cycloaddition reaction, comprising: combining in a solution an alkyne-tagged component, an azide-tagged component and a Cu(I)-Catalyzed Azide-Alkyne Cycloadditions (CuAAC) ligand comprising: a catalytic core; a fluorous tag; and a linker binding the fluorous tag to the catalytic core; filtering the solution through a solid phase extraction filter to remove Cu(I)-ligand catalyst and/or excess ligand. |
| FILED | Wednesday, September 30, 2015 |
| APPL NO | 15/515953 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0039 (20130101) A61K 49/0056 (20130101) A61K 51/088 (20130101) A61K 51/1096 (20130101) Separation B01D 11/0288 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1815 (20130101) Original (OR) Class B01J 2231/34 (20130101) B01J 2531/16 (20130101) Heterocyclic Compounds C07D 249/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758902 | Hofmeister et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ultra Small Fibers, LLC (Wartrace, Tennessee) |
| ASSIGNEE(S) | Ultra Small Fibers, LLC (Wartrace, Tennessee) |
| INVENTOR(S) | William Hudson Hofmeister (Nashville, Tennessee); Alexander Yuryevich Terekhov (Estill Springs, Tennessee); Jose Lino Vasconcelos da Costa (Murfreesboro, Tennessee) |
| ABSTRACT | A semipermeable ultrathin polymer membrane comprises a substantially optically transparent polymer film having a surface area to thickness ratio of at least 1,000,000:1, and an array of precisely spatially ordered pores of a user-selected diameter defined therethrough. Such membranes can be fabricated by providing a mold having a patterned array of nanoholes femtosecond laser ablated in a surface thereof; applying a first polymer solution onto the mold surface so that the first polymer solution infiltrates the nanoholes; allowing the first polymer solution to dry and form a replica of the mold having a plurality of freestanding nanoneedles extending from a surface of the replica; removing the replica from the mold; coating the replica surface with a second polymer solution; drying the second polymer solution to form a porous polymer film; and dissolving the replica in a solvent to release the film from the replica as a semipermeable ultrathin polymer membrane. |
| FILED | Wednesday, May 03, 2017 |
| APPL NO | 15/585424 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Separation B01D 69/12 (20130101) B01D 69/122 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 2200/12 (20130101) B01L 2300/161 (20130101) B01L 2300/168 (20130101) B01L 2300/0819 (20130101) B01L 2300/0887 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/005 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 37/0067 (20130101) B29C 41/02 (20130101) B29C 41/38 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 99/005 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2067/046 (20130101) B29K 2629/04 (20130101) B29K 2995/0026 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/755 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/266 (20130101) B32B 27/306 (20130101) B32B 37/12 (20130101) B32B 38/0008 (20130101) B32B 38/10 (20130101) B32B 2037/243 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2367/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/525 (20130101) G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759735 | Lepore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Florida Atlantic University Board of Trustees (Boca Raton, Florida) |
| ASSIGNEE(S) | Florida Atlantic University Board of Trustees (Boca Raton, Florida) |
| INVENTOR(S) | Salvatore D. Lepore (Delray Beach, Florida); Kenneth Dawson-Scully (Boca Raton, Florida); Elijah J. St. Germain (Davie, Florida); Samantha L. Maki (Delray Beach, Florida); Wesley L. Bollinger (Dallas, Texas); Nadia K. Sial (Boca Raton, Florida) |
| ABSTRACT | Neuroprotective compounds for reducing neurological damage due to cellular stress in an individual are of Formula 1: or an enantiomer, diastereomer, racemic mixture or a pharmaceutically acceptable salt thereof, wherein: Ar=aryl; Y=aryl substituent (ortho, meta, or para) selected from the group consisting of: alkyl, alkyloxy, alkylamino, R5R6N, and halo; X═O, N, or S; R═H, alkyl, aryl, OH, alkyloxy, aryloxy, NH2, alkylamino, R5R6N, or arylamino; R1 and R2=alkylcarbonyl, arylcarbonyl, alkyl, or H, individually; R3=arylCH═CH, alkylCH═CH, alkyl; R4═H, alkyl, or aryl; and R5 and R6=alkyl, individually. Methods of reducing neurological damage due to cellular stress in an individual include administering to the individual during or after the cellular stress a neuroprotective compound of Formula I in a therapeutically effective amount to restore synaptic function during or after the cellular stress. |
| FILED | Friday, January 11, 2019 |
| APPL NO | 16/245587 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Acyclic or Carbocyclic Compounds C07C 62/34 (20130101) C07C 67/03 (20130101) C07C 69/18 (20130101) C07C 69/753 (20130101) Original (OR) Class C07C 2602/44 (20170501) C07C 2602/46 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759740 | Uhrich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Kathryn Uhrich (Riverside, California); Yingyue Zhang (New Brunswick, New Jersey); Allison Faig (New Brunswick, New Jersey); Michael Chikindas (New Brunswick, New Jersey) |
| ABSTRACT | The invention provides an antibacterial compound of formula (I) or a salt thereof, as well as an antibacterial compound of formula (II) or a salt thereof, wherein R1, R2, W, X, Y and n have any of the values defined in the specification. |
| FILED | Friday, March 24, 2017 |
| APPL NO | 16/086927 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/23 (20130101) A61K 31/164 (20130101) A61K 31/164 (20130101) A61K 31/4164 (20130101) A61K 31/4164 (20130101) A61K 31/4168 (20130101) A61K 31/7036 (20130101) A61K 31/7056 (20130101) A61K 31/7056 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic or Carbocyclic Compounds C07C 235/06 (20130101) C07C 235/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759743 | Yu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| INVENTOR(S) | Jin-Quan Yu (San Diego, California) |
| ABSTRACT | Pd(II)-catalyzed g-G(sp3)-H arylation or heteroarylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction. |
| FILED | Thursday, October 19, 2017 |
| APPL NO | 16/344092 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2239 (20130101) B01J 2231/44 (20130101) B01J 2531/824 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 37/04 (20130101) Acyclic or Carbocyclic Compounds C07C 209/68 (20130101) C07C 209/68 (20130101) C07C 211/40 (20130101) C07C 269/04 (20130101) Original (OR) Class C07C 269/04 (20130101) C07C 271/22 (20130101) C07C 2601/08 (20170501) C07C 2601/14 (20170501) C07C 2601/18 (20170501) Heterocyclic Compounds C07D 213/40 (20130101) C07D 213/61 (20130101) C07D 213/64 (20130101) C07D 215/12 (20130101) C07D 241/42 (20130101) C07D 319/18 (20130101) C07D 333/22 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759750 | Abou-Gharbia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Temple University Of The Commonwealth System Of Higher Education (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Magid A. Abou-Gharbia (Exton, Pennsylvania); Benjamin E. Blass (Eagleville, Pennsylvania); Wayne E. Childers (New Hope, Pennsylvania); Mercy Ramanjulu (King of Prussia, Pennsylvania); George C. Morton (Collegeville, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve dysregulation of glutamate homeostasis in its etiology. |
| FILED | Thursday, April 27, 2017 |
| APPL NO | 16/096830 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) A61P 25/28 (20180101) A61P 25/30 (20180101) Heterocyclic Compounds C07D 205/08 (20130101) Original (OR) Class C07D 401/06 (20130101) C07D 401/12 (20130101) C07D 403/06 (20130101) C07D 403/12 (20130101) C07D 471/04 (20130101) C07D 471/10 (20130101) C07D 487/04 (20130101) C07D 487/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759764 | Ritter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Tobias Ritter (Cambridge, Massachusetts); Constanze Nicole Neumann (Somerville, Massachusetts) |
| ABSTRACT | Methods for fluorinating organic compounds utilizing a novel organic reagent are described herein. The invention further discloses the utility of this reagent for incorporation of the 18 F isotope into hydroxyl group-containing organic molecules for PET imaging studies. Preparation of the reagents is described along with isolable intermediate structures from reaction of the reagent with a hydroxyl group-containing organic molecule. |
| FILED | Friday, October 17, 2014 |
| APPL NO | 15/029602 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/04 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/00 (20130101) C07B 59/001 (20130101) C07B 59/007 (20130101) C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 309/04 (20130101) Heterocyclic Compounds C07D 233/70 (20130101) Original (OR) Class C07D 233/84 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759774 | Sarafianos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri); REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri); REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Stefan G. Sarafianos (Columbia, Missouri); Zhengqiang Wang (Eden Prairie, Missouri); Andrew D. Huber (Columbia, Missouri); Jing Tang (Shoreview, Minnesota) |
| ABSTRACT | The present invention provides novel compounds and methods for treating, preventing or inhibiting hepatitis B virus (HBV). |
| FILED | Thursday, September 27, 2018 |
| APPL NO | 16/144274 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/381 (20130101) A61K 31/427 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4155 (20130101) A61K 31/4365 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) Heterocyclic Compounds C07D 333/38 (20130101) Original (OR) Class C07D 409/12 (20130101) C07D 417/12 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759791 | Silverman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Richard B. Silverman (Winnetka, Illinois); Heng-Yen Wang (Kaohsiung, Taiwan); Yajuan Qin (Nanjing, China PRC); Fengwei Zou (Evanston, Illinois); Soo Sung Kang (Evanston, Illinois); Qing Jing (Evanston, Illinois) |
| ABSTRACT | Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity of nitric oxide synthases (NOSs), the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with NOS activity. |
| FILED | Friday, April 07, 2017 |
| APPL NO | 15/482210 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/444 (20130101) A61K 31/496 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 213/73 (20130101) C07D 213/74 (20130101) C07D 401/04 (20130101) C07D 401/06 (20130101) C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759795 | Cushman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); National Institutes of Health (Bethesda, Maryland) |
| ASSIGNEE(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana); UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| INVENTOR(S) | Mark S. Cushman (West Lafayette, Indiana); Daniel E. Beck (West Palm Beach, Florida); Yves Pommier (Bethesda, Maryland) |
| ABSTRACT | The invention described herein pertains to four series of aza-A-ring indenoisoquinolines, which are inhibitors of topoisomerase IB (Top1), and the processes for preparing said aza-A-ring indenoisoquinolines. Also described are methods for treating cancer in mammals using the described aza-A-ring indenoisoquinoline compounds or pharmaceutical formulations thereof. |
| FILED | Wednesday, March 15, 2017 |
| APPL NO | 16/081959 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759800 | Kammerer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fedora Pharmaceuticals Inc. (Edmonton, Canada); Meiji Seika Pharma Co., Ltd. (Tokyo, Japan) |
| ASSIGNEE(S) | FEDORA PHARMACEUTICALS INC. (Alberta, Canada); MEIJI SEIKA PHARMA CO., LTD. (Tokyo, Japan) |
| INVENTOR(S) | Michael Kammerer (Basel, Switzerland); Frederic Ran (Basel, Switzerland) |
| ABSTRACT | The present invention relates to crystalline forms of a diazabicyclooctane derivative represented by Compound I, the process for producing the same and methods for using the same: |
| FILED | Tuesday, September 25, 2018 |
| APPL NO | 16/140601 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Heterocyclic Compounds C07D 471/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759803 | Ye et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Keqiang Ye (Lilburn, Georgia); Haian Fu (Decatur, Georgia); Yuhong Du (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to asparagine endopeptidase inhibitors for managing cancer and compositions related thereto. In certain embodiments, the asparagine endopeptidase inhibitors are substituted 3,7-dihydropurine-2,6-dione derivatives useful for treating or preventing metastasis, tumor growth, and/or cancer. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising an asparagine endopeptidase inhibitor and a pharmaceutically acceptable excipient. In certain embodiments, the disclosure relates to methods of treating a cancer comprising administering an effective amount of pharmaceutical composition a asparagine endopeptidase inhibitor disclosed herein to a subject in need thereof. |
| FILED | Wednesday, April 08, 2015 |
| APPL NO | 15/303481 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/433 (20130101) A61K 31/496 (20130101) A61K 31/519 (20130101) A61K 31/522 (20130101) A61K 31/4015 (20130101) A61K 31/4168 (20130101) A61K 31/5355 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 207/452 (20130101) C07D 215/06 (20130101) C07D 257/04 (20130101) C07D 273/02 (20130101) C07D 277/54 (20130101) C07D 285/135 (20130101) C07D 471/04 (20130101) C07D 473/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759823 | Gervay-Hague et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jacquelyn Gervay-Hague (Davis, California); Matthew Schombs (Oxford, United Kingdom) |
| ABSTRACT | The present invention provides novel, regioselectively-acylated oligosaccharide compounds and methods for preparing them. In another aspect, the invention provides a method for preparing a selectively-acylated oligosaccharide. The method includes forming a reaction mixture containing a protected oligosaccharide and an acylating agent. The protected oligosaccharide includes at least three hydroxyl moieties and each hydroxyl moiety is protected with a silyl protecting group. The reaction mixture is formed under conditions sufficient to selectively replace at least one silyl protecting group with a —C(0)-C1_6 alkyl group, and the selectively-acylated oligosaccharide comprises at least one —C(0)-C1_6 alkyl group and at least one silyl protecting group. |
| FILED | Tuesday, August 28, 2018 |
| APPL NO | 16/115365 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 3/06 (20130101) C07H 13/04 (20130101) Original (OR) Class C07H 23/00 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/55 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759833 | Norris |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Steven J. Norris (Houston, Texas) |
| ABSTRACT | The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies. |
| FILED | Wednesday, May 15, 2019 |
| APPL NO | 16/412913 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/02 (20130101) Peptides C07K 14/20 (20130101) Original (OR) Class C07K 17/08 (20130101) C07K 17/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/48 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/56911 (20130101) G01N 2333/20 (20130101) G01N 2469/20 (20130101) G01N 2800/26 (20130101) Technologies for Adaptation to Climate Change Y02A 50/40 (20180101) Y02A 50/57 (20180101) Y02A 50/401 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759834 | Kossiakoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Anthony A. Kossiakoff (Chicago, Illinois); Lucas J. Bailey (Chicago, Illinois) |
| ABSTRACT | Methods and compositions are provided concerning polypeptides with modifications that increase its binding affinity for the Fab region of an antibody. Methods include using the polypeptides for isolating, detecting, purifying, measuring and quantifying Fab polypeptides. Other embodiments concern kits, compositions, and solid supports containing the polypeptides and for using the polypeptides for isolating, detecting, purifying, measuring and quantifying Fab polypeptide. |
| FILED | Friday, October 16, 2015 |
| APPL NO | 15/519576 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 1/22 (20130101) C07K 14/315 (20130101) Original (OR) Class C07K 16/00 (20130101) C07K 17/00 (20130101) C07K 2317/55 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101) C07K 2319/70 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54353 (20130101) G01N 2333/315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759836 | Disis et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Mary L. Disis (Seattle, Washington); Elizabeth Broussard (Seattle, Washington) |
| ABSTRACT | The present application describes compositions that include an epitope of a peptide that elicits an immune response in a subject following administration. The compositions described herein include nucleic acids. The present application also describes compositions that include peptides. Also described herein are methods that include administering a composition comprising an epitope of a peptide to a subject in need thereof. |
| FILED | Friday, July 17, 2015 |
| APPL NO | 15/327225 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/0011 (20130101) A61K 48/00 (20130101) Peptides C07K 7/00 (20130101) C07K 14/00 (20130101) C07K 14/47 (20130101) Original (OR) Class C07K 14/71 (20130101) C07K 14/78 (20130101) C07K 14/82 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 9/16 (20130101) C12N 15/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759838 | Lenardo et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, Maryland) |
| INVENTOR(S) | Michael J. Lenardo (Bethesda, Maryland); Jian Li (Rockville, Maryland); Lixin Zheng (Rockville, Maryland); Jae W. Lee (Philadelphia, Pennsylvania); Wei Lu (Rockville, Maryland) |
| ABSTRACT | Disclosed is a protein comprising no more than three human autoantigenic proteins, wherein a first human autoantigenic protein comprises a truncated myelin oligodendrocyte glycoprotein (MOG) amino acid sequence, a second human autoantigenic protein comprises a myelin basic protein (MBP) amino acid sequence, and a third human autoantigenic protein comprises a truncated proteolipid protein (PLP) amino acid sequence. Also disclosed are related nucleic acids, pharmaceutical compositions, methods of treating a demyelinating disease, and methods of producing the proteins. |
| FILED | Wednesday, March 09, 2016 |
| APPL NO | 15/556738 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/13 (20130101) A61K 38/1709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/4713 (20130101) Original (OR) Class C07K 2319/21 (20130101) C07K 2319/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759846 | Graham et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Barney Graham (Rockville, Maryland); Wing-Pui Kong (Germantown, Maryland); Kayvon Modjarrad (Bethesda, Maryland); Lingshu Wang (North Potomac, Maryland); Wei Shi (Rockville, Maryland); Michael Gordon Joyce (Washington, District of Columbia); Masaru Kanekiyo (Chevy Chase, Maryland); John Mascola (Rockville, Maryland) |
| ABSTRACT | Methods of inducing an immune response in a subject to the Middle East respiratory syndrome coronavirus (MERS-CoV) are provided. In several embodiments, the immune response is a protective immune response that inhibits or prevents MERS-CoV infection in the subject. Recombinant MERS-CoV polypeptides and nucleic acid molecules encoding same are also provided. Additionally, neutralizing antibodies that specifically bind to MERS-CoV S protein and antigen binding fragments thereof are disclosed. The antibodies and antigen binding fragments are useful, for example, in methods of detecting MERS-CoV S protein in a sample or in a subject, as well as methods of preventing and treating a MERS-CoV infection in a subject. |
| FILED | Friday, May 03, 2019 |
| APPL NO | 16/403211 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/215 (20130101) A61K 2039/53 (20130101) A61K 2039/57 (20130101) A61K 2039/545 (20130101) A61K 2039/55505 (20130101) A61K 2039/55566 (20130101) A61K 2039/55572 (20130101) Peptides C07K 14/005 (20130101) C07K 14/165 (20130101) C07K 16/10 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/52 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20034 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759851 | Gavathiotis et al. |
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| FUNDED BY |
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| APPLICANT(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York); THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Toronto, Canada) |
| ASSIGNEE(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York); THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Toronto, Canada) |
| INVENTOR(S) | Evripidis Gavathiotis (Flushing, New York); Jonathan R. Lai (Dobbs Ferry, New York); Sachdev Sidhu (Toronto, Canada) |
| ABSTRACT | Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N-terminal activation site of BCL-2-associated X-protein (BAX) and inhibit BAX activation. Also disclosed are methods of using the Fabs for measuring inactive monomeric BAX levels, screening for small molecules that bind to an N-terminal activation site of BAX, inhibiting apoptotic cell death, and predicting the ability of a cancer therapy to promote apoptotic cell death. |
| FILED | Wednesday, January 30, 2019 |
| APPL NO | 16/261703 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 47/6843 (20170801) Peptides C07K 16/005 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/10 (20130101) C07K 2317/24 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 2500/04 (20130101) G01N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759863 | Ware et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California) |
| INVENTOR(S) | Carl F. Ware (La Jolla, California); John R. Sedy (La Jolla, California) |
| ABSTRACT | The present invention relate to the discovery that BTLA, IL-7 and RORγt modulate the activity and expression of γδT cells. Specifically, the present invention provides methods of modulating γδT cell homeostasis and function by regulating expression of BTLA. The present invention further provides agents which modulate the activity and expression of BTLA, RORyt and IL-7 and methods for screening of such agents. The present invention also provides methods for treating autoimmune or inflammatory diseases using modulators of BTLA, RORyt and IL-7. |
| FILED | Thursday, September 04, 2014 |
| APPL NO | 14/916986 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 38/2046 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/5418 (20130101) C07K 16/2878 (20130101) Original (OR) Class C07K 2317/75 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1138 (20130101) C12N 2310/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759869 | Spriggs et al. |
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| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | David Spriggs (New York, New York); Dharmarao Thapi (Bayside Hills, New York) |
| ABSTRACT | The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to a polypeptide, or antigenic portion thereof, wherein the polypeptide is selected from a) MUC16 ectodomain polypeptide, b) MUC16 cytoplasmic domain polypeptide, and c) MUC16 extracellular domain polypeptide that contains a cysteine loop polypeptide. The invention's antibodies and compositions containing them are useful in diagnostic and therapeutic applications for diseases in which MUC16 is overexpressed, such as cancer. |
| FILED | Tuesday, September 05, 2017 |
| APPL NO | 15/695311 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) A61K 2039/5156 (20130101) Peptides C07K 16/3092 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/77 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57488 (20130101) G01N 2333/705 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759877 | Schoenfisch et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Mark H. Schoenfisch (Chapel Hill, North Carolina); Yuan Lu (Chapel Hill, North Carolina) |
| ABSTRACT | The presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides, in particular, polyglucosamines, and their use in biomedical and pharmaceutical applications. More particularly, in some embodiments, the presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides that release nitric oxide in a controlled and targeted manner, thereby prolonging the therapeutic effects of nitric oxide and improving the specificity of nitric oxide delivery to targeted cells and/or tissues. |
| FILED | Friday, December 08, 2017 |
| APPL NO | 15/836121 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) Polysaccharides; Derivatives Thereof C08B 37/00 (20130101) C08B 37/003 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 5/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760048 | Nicholas et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Cory R. Nicholas (San Francisco, California); John L. Rubenstein (San Francisco, California); Arnold R. Kriegstein (Mill Valley, California); Arturo Alvarez-Buylla (Woodside, California) |
| ABSTRACT | Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons. |
| FILED | Monday, September 10, 2018 |
| APPL NO | 16/126594 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) Original (OR) Class C12N 5/0619 (20130101) C12N 15/63 (20130101) C12N 2500/90 (20130101) C12N 2501/13 (20130101) C12N 2501/41 (20130101) C12N 2501/727 (20130101) C12N 2501/999 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760057 | Thomson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | James A. Thomson (Madison, Wisconsin); Jue Zhang (Madison, Wisconsin) |
| ABSTRACT | Methods of using a small molecule MYH11 agonist to inhibit intimal hyperplasia and to maintain a contractile phenotype in vitro and in vivo are described. Also described herein are methods for generating human contractile smooth muscle cells from human pluripotent stem cells under defined conditions in the presence of the small molecule MYH11 agonist. |
| FILED | Friday, July 06, 2018 |
| APPL NO | 16/029068 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4375 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0661 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/42 (20130101) C12N 2501/115 (20130101) C12N 2501/135 (20130101) C12N 2501/155 (20130101) C12N 2501/165 (20130101) C12N 2501/999 (20130101) C12N 2506/02 (20130101) C12N 2506/03 (20130101) C12N 2506/04 (20130101) C12N 2510/00 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760061 | Cooke et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | John P. Cooke (Houston, Texas); Eduard Yakubov (Houston, Texas) |
| ABSTRACT | The nuclear reprogramming of somatic cells with mRNA encoding reprogramming factors is shown to be greatly accelerated by activation of innate immune responses in the somatic cell. Methods of activating innate immunity include activation of PKR, of toll-like receptors, e.g. TLR3, etc. In some embodiments the mRNA provides the activator of innate immunity. |
| FILED | Wednesday, April 05, 2017 |
| APPL NO | 15/479979 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) Original (OR) Class C12N 2501/04 (20130101) C12N 2501/60 (20130101) C12N 2501/90 (20130101) C12N 2501/602 (20130101) C12N 2501/603 (20130101) C12N 2501/604 (20130101) C12N 2501/606 (20130101) C12N 2501/608 (20130101) C12N 2501/998 (20130101) C12N 2506/09 (20130101) C12N 2506/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760064 | Joung et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Morgan Maeder (Brookline, Massachusetts) |
| ABSTRACT | Methods and constructs for RNA-guided targeting of transcriptional activators to specific genomic loci. |
| FILED | Friday, March 14, 2014 |
| APPL NO | 14/211117 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 14/4705 (20130101) C07K 2319/40 (20130101) C07K 2319/43 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/63 (20130101) C12N 15/1136 (20130101) C12N 2310/20 (20170501) C12N 2310/318 (20130101) C12N 2310/321 (20130101) C12N 2310/3231 (20130101) C12N 2310/3341 (20130101) C12N 2310/3521 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760065 | Lu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Timothy Kuan-Ta Lu (Charlestown, Massachusetts); Robert James Citorik (Kingston, New Hampshire); Mark Kyle Mimee (Cambridge, Massachusetts) |
| ABSTRACT | Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest. |
| FILED | Wednesday, September 03, 2014 |
| APPL NO | 14/475785 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760077 | Cheng et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); National Yang-Ming University (Taipei, Taiwan) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); National Yang-Ming University (Taipei, Taiwan) |
| INVENTOR(S) | Tzu-Hao Cheng (Taipei, Taiwan); Chia-Rung Liu (Tainan, Taiwan); Tzu-Han Wang (Taipei, Taiwan); Stanley N. Cohen (Stanford, California) |
| ABSTRACT | Aspects of the invention include methods of selectively reducing the deleterious activity of mutant extended trinucleotide repeat containing genes in a cell, as well as compositions used in such methods. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended trinucleotide repeat containing gene may be selectively reduced in a variety of different ways, e.g., by selectively decreasing SPT4 mediated transcriptional activity, by enhancing functionality of proteins encoded thereby, etc. Aspects of the invention further include assays for identifying agents that find use in methods of the invention, e.g. as summarized above. Methods and compositions of the invention find use in a variety of different applications, including the prevention or treatment of disease conditions associated with the presence of genes containing mutant extended trinucleotide repeats, such as Huntington's Disease (HD). |
| FILED | Wednesday, December 06, 2017 |
| APPL NO | 15/833891 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 51/10 (20130101) A61K 51/1075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2320/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760097 | Picker et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| INVENTOR(S) | Louis Picker (Portland, Oregon); Klaus Früh (Portland, Oregon); Scott G. Hansen (Portland, Oregon) |
| ABSTRACT | Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of the heterologous antigen. The CMV vector may comprise a deleterious mutation in the US11 glycoprotein or a homolog thereof. |
| FILED | Thursday, November 30, 2017 |
| APPL NO | 15/827649 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2710/16121 (20130101) C12N 2710/16143 (20130101) C12N 2740/15034 (20130101) C12N 2740/15071 (20130101) C12N 2800/204 (20130101) Technologies for Adaptation to Climate Change Y02A 50/386 (20180101) Y02A 50/388 (20180101) Y02A 50/394 (20180101) Y02A 50/412 (20180101) Y02A 50/466 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760113 | Parker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| INVENTOR(S) | Laurie L. Parker (Minneapolis, Minnesota); Tzu-Yi Yang (West Lafayette, Indiana); Vincent Davisson (West Lafayette, Indiana) |
| ABSTRACT | The invention provides cellular assays for detecting the activity of one or more kinase from multiple conditions simultaneously, by encoding biochemically identical substrates with isotope labels that enable them to be distinguished in pooled samples by mass spectrometry. |
| FILED | Monday, July 11, 2016 |
| APPL NO | 15/207379 |
| ART UNIT | 1699 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760117 | Jain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Miten Jain (Santa Cruz, California); Hugh Edward Olsen (Santa Cruz, California); Mark A. Akeson (Santa Cruz, California) |
| ABSTRACT | Disclosed are methods for polynucleotide sequencing that detect the location of selected nucleobases with greater precision. The methods can be used to determine the location and nature of modified bases in a polynucleotide, that is, non-canonical bases, or to improve accuracy of sequencing of “problem” regions of DNA sequencing such as homopolymers, GC rich areas, etc. The sequencing method exemplified is nanopore sequencing. Nanopore sequencing is used to generate a unique signal at a point in a polynucleotide sequence where an abasic site (AP site, or apurinic or apyrimidinic site) exists. As part of the method, an abasic site is specifically created enzymatically using a DNA glycosylase that recognizes a pre-determined nucleobase species and cleaves the N-glycosidic bond to release only that base, leaving an AP site in its place. |
| FILED | Tuesday, April 05, 2016 |
| APPL NO | 15/564386 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) Original (OR) Class C12Q 1/6827 (20130101) C12Q 1/6827 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 2521/531 (20130101) C12Q 2521/531 (20130101) C12Q 2521/531 (20130101) C12Q 2521/531 (20130101) C12Q 2521/531 (20130101) C12Q 2525/119 (20130101) C12Q 2525/119 (20130101) C12Q 2525/119 (20130101) C12Q 2525/119 (20130101) C12Q 2525/119 (20130101) C12Q 2537/164 (20130101) C12Q 2537/164 (20130101) C12Q 2537/164 (20130101) C12Q 2545/101 (20130101) C12Q 2545/101 (20130101) C12Q 2545/101 (20130101) C12Q 2545/101 (20130101) C12Q 2563/116 (20130101) C12Q 2563/116 (20130101) C12Q 2563/116 (20130101) C12Q 2563/116 (20130101) C12Q 2563/116 (20130101) C12Q 2565/631 (20130101) C12Q 2565/631 (20130101) C12Q 2565/631 (20130101) C12Q 2565/631 (20130101) C12Q 2565/631 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760119 | Yoon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Jeong-Yeol Yoon (Tucson, Arizona); Dustin Harshman (San Diego, California) |
| ABSTRACT | Disclosed are devices, systems and methods of use utilizing interfacial effects enabling droplet actuation, inhibition and early sensing of molecular reactions, such as of polymerase chain reaction. |
| FILED | Friday, October 23, 2015 |
| APPL NO | 15/517028 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) B01L 7/54 (20130101) B01L 7/525 (20130101) B01L 2200/0673 (20130101) B01L 2300/185 (20130101) B01L 2300/0861 (20130101) B01L 2400/0475 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/686 (20130101) C12Q 2523/303 (20130101) C12Q 2527/101 (20130101) C12Q 2563/159 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760127 | Salk et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| INVENTOR(S) | Jesse Salk (Seattle, Washington); Lawrence A. Loeb (Bellevue, Washington); Michael Schmitt (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 16/503382 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class C12Q 2525/179 (20130101) C12Q 2525/185 (20130101) C12Q 2525/191 (20130101) C12Q 2525/191 (20130101) C12Q 2535/119 (20130101) C12Q 2535/119 (20130101) C12Q 2535/122 (20130101) C12Q 2563/179 (20130101) C12Q 2565/514 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760128 | Watnick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Athena Diagnostics, Inc. (Worcester, Massachusetts); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | ATHENA DIAGNOSTICS, INC. (Worcester, Massachusetts); THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Terry J. Watnick (Chevy Chase, Maryland); Miguel Garcia-Gonzalez (Brion, Spain); Gregory G. Germino (Chevy Chase, Maryland); Jeffery G. Jones (Wilbraham, Massachusetts) |
| ABSTRACT | The present invention relates to methods of detecting novel mutations in a PKD1 and/or PKD2 gene that have been determined to be associated with autosomal dominant polycystic kidney disease (ADPKD) in order to detect or predict the occurrence of ADPKD in an individual. |
| FILED | Wednesday, May 28, 2014 |
| APPL NO | 14/289160 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760131 | Woods et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE ADMINSTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); OCHSNER CLINIC FOUNDATION (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Cooper Woods (New Orleans, Louisiana); Hernan Antonio Bazan (New Orleans, Louisiana) |
| ABSTRACT | Disclosed are methods of, and assay and kits for, detecting and diagnosing arterial plaque rupture using the expression of miR-222, mi-221 and circ284. Also disclosed are methods of treating arterial plaque rupture and methods of identifying agents for use thin the treatment of arterial plaque rupture. |
| FILED | Tuesday, February 23, 2016 |
| APPL NO | 15/553135 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6813 (20130101) C12Q 1/6874 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760132 | Luo et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Jianhua Luo (Wexford, Pennsylvania); George Konstantine Michalopoulos (Pittsburgh, Pennsylvania); Joel B. Nelson (Pittsburgh, Pennsylvania); Chi Song (New Haven, Connecticut); Chien-Cheng Tseng (Pittsburgh, Pennsylvania); Yanping Yu (Wexford, Pennsylvania) |
| ABSTRACT | The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid relapse, of his cancer. It is based, at least in part, on the results of a comprehensive genome analysis on 241 prostate cancer samples (104 prostate cancer, 85 matched bloods, 49 matched benign prostate tissues adjacent to cancer, and 3 cell lines) which indicate that (i) genome copy number variation (CNV) occurred in both cancer and non-cancer tissues, and (ii) CNV predicts prostate cancer progression. |
| FILED | Monday, July 21, 2014 |
| APPL NO | 14/336965 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761001 | Wikswo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | John P. Wikswo (Brentwood, Tennessee); Philip C. Samson (Nashville, Tennessee); Jeffrey M. Davidson (Nashville, Tennessee); Stephen R. Koch (Madison, Tennessee); Veniamin Yu Sidorov (Nashville, Tennessee) |
| ABSTRACT | A device for measuring a tension of a bio-object construct as it is being stretched that includes a microscope, a holding member for accommodating the bio-object, and a probe. The microscope includes a condenser, an objective and a stage positioned therebetween. The stage is movable along a horizontal plane. The holding member is fixable on the stage. The probe has a first end attached to the condenser, and a second end placed in the holding member. The stage operably moves such that the bio-object construct moves toward the second end of the probe and contacts with the second end of the probe, thereby causing a displacement of the second end of the probe and a displacement of the bio-object construct, which are used to measure the tension of the bio-object construct. |
| FILED | Tuesday, January 17, 2017 |
| APPL NO | 16/064151 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/20 (20130101) Original (OR) Class G01N 2203/028 (20130101) G01N 2203/0089 (20130101) G01N 2203/0094 (20130101) G01N 2203/0647 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0004 (20130101) G02B 21/08 (20130101) G02B 21/26 (20130101) G02B 21/365 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
10761043 — Graphene-based nanopore and nanostructure devices and methods for macromolecular analysis
| US 10761043 | Drndic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Marija Drndic (Philadelphia, Pennsylvania); Ken Healy (Cambridge, Massachusetts); Meni Wanunu (Chestnut Hill, Massachusetts); Christopher Ali Merchant (Baltimore, Maryland); Matthew Puster (Philadelphia, Pennsylvania); Kimberly Elizabeth Venta (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Marija Drndic (Philadelphia, Pennsylvania); Ken Healy (Cambridge, Massachusetts); Meni Wanunu (Chestnut Hill, Massachusetts); Christopher Ali Merchant (Baltimore, Maryland); Matthew Puster (Philadelphia, Pennsylvania); Kimberly Elizabeth Venta (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are graphene-based nanopore and nanostructure devices, which devices may include an insulating layer disposed atop the graphene, which can be in a planar shape or nanostructured into a ribbon or other shapes, containing a single graphene layer or several layers. Graphene layers and nanostructures can be placed nearby horizontally or stacked vertically. Also provided are related methods of fabricating and processing such devices and also methods of using such devices in macromolecular analysis. |
| FILED | Friday, July 20, 2012 |
| APPL NO | 13/553853 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/26 (20130101) Original (OR) Class G01N 33/48721 (20130101) Technical Subjects Covered by Former US Classification Y10T 156/10 (20150115) Y10T 156/1056 (20150115) Y10T 436/143333 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761083 | Ouyang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Zheng Ouyang (West Lafayette, Indiana); He Wang (West Lafayette, Indiana); Nicholas E. Manicke (West Lafayette, Indiana); Robert Graham Cooks (West Lafayette, Indiana); Qian Yang (West Lafayette, Indiana); Jiangjiang Liu (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to a sample dispenser including an internal standard and methods of use thereof. |
| FILED | Monday, November 21, 2016 |
| APPL NO | 15/357048 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/10 (20130101) G01N 1/28 (20130101) G01N 1/286 (20130101) G01N 33/491 (20130101) G01N 33/492 (20130101) Original (OR) Class G01N 33/48714 (20130101) G01N 33/48785 (20130101) G01N 2001/2893 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0009 (20130101) H01J 49/16 (20130101) H01J 49/0027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761088 | An et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Woojin An (Los Angeles, California); Kyunghwan Kim (Los Angeles, California) |
| ABSTRACT | Although limited proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during mammalian differentiation, the specific genomic sites targeted for H3NT proteolysis and the functional significance of H3NT cleavage remain largely unknown. Here Applicant reports the first method to identify and examine H3NT-cleaved regions in mammals, called ChIP of acetylated chromatin (ChIPac). By applying ChIPac-Seq to an established cell model of osteoclast differentiation, Applicant discovered that H3NT proteolysis is selectively targeted near transcription start sites of a small group of genes and that most H3NT-cleaved genes displayed significant expression changes during osteoclastogenesis. Applicant also discovered that the principal H3NT protease of osteoclastogenesis is matrix metalloproteinase 9 (MMP-9). In contrast to other known H3NT proteases, MMP-9 primarily cleaved H3K18-Q19 in vitro and in cells. Furthermore, Applicant's results support CBP/p300-mediated acetylation of H3K18 as a central regulator of MMP-9 H3NT protease activity both in vitro and at H3NT-cleavage sites during osteoclastogenesis. Importantly, Applicant found that abrogation of H3NT proteolysis impaired osteoclastogenic gene activation concomitant with defective osteoclast differentiation. Applicant's collective results support the necessity of MMP-9-dependent H3NT proteolysis in regulating gene pathways required for proficient osteoclastogenesis. |
| FILED | Monday, March 13, 2017 |
| APPL NO | 15/457951 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761099 | Ziady et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| INVENTOR(S) | Assem Ziady (Newport, Kentucky); Rhonda Szczesniak (Burlington, Kentucky); John Clancy (Cincinnati, Ohio); Cole Brokamp (Cincinnati, Ohio) |
| ABSTRACT | Disclosed herein are methods for detecting protein expression in an individual diagnosed with cystic fibrosis. The methods, in certain aspects, include the steps of obtaining a sample from said individual and detecting expression in said sample of each protein of a protein set. The method may further include the step of determining expression level of one or more proteins of the protein set. The disclosed methods may be used to predict one or more clinical parameters in an individual having cystic fibrosis. |
| FILED | Wednesday, March 21, 2018 |
| APPL NO | 15/927575 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/914 (20130101) G01N 2800/50 (20130101) G01N 2800/56 (20130101) G01N 2800/382 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761167 | Griswold et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | Case Western Reserve University (Cleveland, Ohio) |
| INVENTOR(S) | Mark A. Griswold (Shaker Heights, Ohio); Mingrui Yang (Beachwood, Ohio) |
| ABSTRACT | A method for creating a dictionary for a magnetic resonance fingerprinting (MRF) reconstruction includes training a semi-supervised learning system based on at least a set of MRF data and a set of control variables and generating a plurality of signal evolutions using the trained semi-supervised learning system. The method also includes generating an MRF dictionary using the plurality of signal evolutions generated using the trained semi-supervised learning system and storing the MRF dictionary in a memory. In one embodiment, the semi-supervised learning system is a MRF generative adversarial network (GAN). |
| FILED | Wednesday, April 17, 2019 |
| APPL NO | 16/387264 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4828 (20130101) Original (OR) Class G01R 33/5608 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761171 | Gulani et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| INVENTOR(S) | Vikas Gulani (Shaker Heights, Ohio); Nicole Seiberlich (Shaker Heights, Ohio); Mark A. Griswold (Shaker Heights, Ohio); Yong Chen (Beachwood, Ohio); Bhairav B. Mehta (Cleveland, Ohio); Simone Coppo (Cleveland, Ohio) |
| ABSTRACT | A system and method for generating quantitative images of a subject using a nuclear magnetic resonance system. The method includes performing a navigator module to acquire navigator data, and performing an acquisition module during free breathing of the subject to acquire NMR data from the subject that contains one or more resonant species that simultaneously produce individual NMR signals in response to the acquisition module. The above steps are repeated to acquire data from a plurality of partitions across the volume. The navigator data is analyzed to determine if the NMR data meets a predetermined condition and if not, the above steps are repeated for at least an affected partition corresponding to NMR data that did not meet the predetermined condition. The NMR data is compared to a dictionary of signal evolutions to determine quantitative values for two or more parameters of the resonant species in the volume. |
| FILED | Thursday, March 22, 2018 |
| APPL NO | 15/928647 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/4818 (20130101) G01R 33/5602 (20130101) G01R 33/5607 (20130101) G01R 33/5613 (20130101) G01R 33/5659 (20130101) G01R 33/5676 (20130101) G01R 33/56509 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761419 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oumeng Zhang (St. Louis, Missouri); Matthew D. Lew (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Oumeng Zhang (St. Louis, Missouri); Matthew D. Lew (St. Louis, Missouri) |
| ABSTRACT | Systems and methods for use in tri-spot point spread function imaging are provided that include a phase mask. The phase mask includes three partitions that each include a subset of the total area that is asymmetrical to other partitions. Each partition includes a phase delay ramp aligned along a phase delay axis, and includes a gradient of phase delays. Each phase delay axis is oriented in a different direction with respect to each other. Included is a source that outputs an excitation beam into a sample containing at least one light emitter that emits a radiation pattern when illuminated. Included is at least one sensor arranged to capture at least one image of the radiation pattern and a phase mask positioned between the at least one emitter and the at least one sensor. The phase mask is configured to produce a tri-spot point spread function. |
| FILED | Tuesday, April 17, 2018 |
| APPL NO | 15/955559 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) G02B 21/0064 (20130101) G02B 21/0076 (20130101) G02B 21/361 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 1/26 (20130101) Original (OR) Class G03F 1/44 (20130101) G03F 7/70191 (20130101) G03F 9/7026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 10758174 | Widge et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Alik S. Widge (Somerville, Massachusetts); Thilo Deckersbach (Boston, Massachusetts); Darin Dougherty (Boston, Massachusetts); Emad Eskandar (Nahant, Massachusetts); Kristen Ellard (Boston, Massachusetts) |
| ABSTRACT | A system and method for diagnosing mental or emotional disorders is disclosed. An affective BCI component is incorporated into a closed loop, symptom—responsive psychiatric DBS system. A series of input data related to a brain of the patient is acquired while the patient performs a battery of behavioral tasks. From the patient's performance on the task battery, the system identifies what is abnormal for that individual patient in terms of functional domains. Patient-specific behavioral measurements are then linked to patterns of activation and de-activation across different brain regions, identifying specific structures that are the source of the patient's individual impairment. |
| FILED | Wednesday, April 22, 2015 |
| APPL NO | 15/305551 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/112 (20130101) A61B 3/113 (20130101) A61B 5/0008 (20130101) A61B 5/024 (20130101) A61B 5/053 (20130101) A61B 5/055 (20130101) A61B 5/0075 (20130101) A61B 5/165 (20130101) A61B 5/0205 (20130101) A61B 5/0402 (20130101) A61B 5/0488 (20130101) A61B 5/0816 (20130101) A61B 5/04008 (20130101) A61B 5/4064 (20130101) A61B 5/4836 (20130101) Original (OR) Class A61B 6/037 (20130101) A61B 8/0808 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101) A61N 1/0534 (20130101) A61N 1/3787 (20130101) A61N 1/36096 (20130101) A61N 1/36132 (20130101) A61N 1/36135 (20130101) A61N 1/36139 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 20/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758182 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Joseph Wang (San Diego, California); Joshua Ray Windmiller (Del Mar, California) |
| ABSTRACT | Techniques and systems are disclosed for implementing textile-based screen-printed amperometric or potentiometric sensors. The chemical sensor can include carbon based electrodes to detect at least one of NADH, hydrogen peroxide, potassium ferrocyanide, TNT or DNT, in liquid or vapor phase. In one application, underwater presence of chemicals such as heavy metals and explosives is detected using the textile-based sensors. |
| FILED | Tuesday, November 07, 2017 |
| APPL NO | 15/806230 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 1/002 (20130101) Diagnosis; Surgery; Identification A61B 5/0002 (20130101) A61B 5/021 (20130101) A61B 5/0205 (20130101) A61B 5/0245 (20130101) A61B 5/742 (20130101) A61B 5/1477 (20130101) A61B 5/1486 (20130101) A61B 5/02444 (20130101) A61B 5/4266 (20130101) A61B 5/4845 (20130101) A61B 5/4884 (20130101) A61B 5/6802 (20130101) A61B 5/6804 (20130101) Original (OR) Class A61B 5/6807 (20130101) A61B 5/6808 (20130101) A61B 5/6831 (20130101) A61B 5/14517 (20130101) A61B 5/14532 (20130101) A61B 5/14546 (20130101) A61B 2560/0214 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/308 (20130101) G01N 27/3271 (20130101) G01N 33/22 (20130101) G01N 33/0057 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/038 (20130101) H05K 3/1216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758545 | Ichida et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Justin Ichida (Los Angeles, California); Shaoyu Lin (Monterey Park, California); Yichen Li (Oxford, United Kingdom); Yingxiao Shi (Los Angeles, California) |
| ABSTRACT | Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered C9ORF72 protein activity. In one aspect, the method includes a step of administering an effective dose of a pharmaceutical composition to a subject in need thereof, thereby rescuing the defects associated with altered C9ORF72 protein activity. Also described are methods for identifying a compound for inhibiting motor neuron degeneration. |
| FILED | Friday, June 24, 2016 |
| APPL NO | 15/579546 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/5377 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758605 | Matoba et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Nobuyuki Matoba (Owensboro, Kentucky); Keegan Baldauf (Louisville, Kentucky); Joshua Royal (Owensboro, Kentucky) |
| ABSTRACT | Protein complex variants, compositions, and methods of use thereof are provided. The protein complex variant includes a cholera toxin B subunit variant having one or more modifications thereto. The method of use thereof includes treating a disease by administering an effective amount of a composition including a cholera toxin B subunit variant to a subject in need thereof. |
| FILED | Wednesday, June 29, 2016 |
| APPL NO | 15/740622 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/107 (20130101) Original (OR) Class A61K 2039/58 (20130101) A61K 2039/82 (20180801) A61K 2039/542 (20130101) A61K 2039/55544 (20130101) Peptides C07K 14/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758630 | Sample et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jennifer L. Sample (Bethesda, Maryland); Julia B. Patrone (Ellicott City, Maryland); Jason J. Benkoski (Ellicott City, Maryland); Jennifer L. Breidenich (Atlanta, Georgia); Lisa A. Kelly (Ellicott City, Maryland); Huong Le (Olney, Maryland); James C. Crookston (Falls Church, Virginia); Marcia W. Patchan (Columbia, Maryland); Luis Garza (Baltimore, Maryland); Xiomara Calderon-Colon (Laurel, Maryland); Joshua T. Wolfe (Bethesda, Maryland); Mellisa L. Theodore (Nottingham, Maryland); Amanda Nelson (Hummelstown, Pennsylvania); Sewon Kang (Phoenix, Maryland) |
| ABSTRACT | A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The hydrophobic particles comprise a mean particle size of less than about 10 nm, and the nanoemulsion further includes one or more pharmaceutically active agents. |
| FILED | Wednesday, September 19, 2012 |
| APPL NO | 13/622666 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/1075 (20130101) A61K 47/44 (20130101) A61K 49/0021 (20130101) Original (OR) Class A61K 49/0078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758633 | Wei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | He Wei (Cambridge, Massachusetts); Oliver T. Bruns (Boston, Massachusetts); Ou Chen (Mansfield, Massachusetts); Moungi G. Bawendi (Cambridge, Massachusetts) |
| ABSTRACT | A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging. |
| FILED | Monday, October 01, 2018 |
| APPL NO | 16/149082 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/1839 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758738 | Chiel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Hillel Chiel (Cleveland, Ohio); Niloy Bhadra (Cleveland, Ohio); Mike Jenkins (Cleveland, Ohio); Emilie Lothet (Cleveland, Ohio); Tina Vrabec (Cleveland, Ohio); Kevin Kilgore (Cleveland, Ohio); Narendra Bhadra (Cleveland, Ohio); Eric Duco Jansen (Cleveland, Ohio) |
| ABSTRACT | One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal. |
| FILED | Tuesday, March 17, 2015 |
| APPL NO | 15/126610 |
| ART UNIT | 3737 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/007 (20130101) A61F 2007/0071 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/06 (20130101) A61N 1/28 (20130101) A61N 1/403 (20130101) Original (OR) Class A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 5/0622 (20130101) A61N 5/0625 (20130101) A61N 7/02 (20130101) A61N 2005/067 (20130101) A61N 2005/0659 (20130101) A61N 2007/0021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758983 | Vaia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Vaia (Beavercreek, Ohio); Kyoungweon Park (Beavercreek, Ohio) |
| ABSTRACT | A method for synthesizing nanostructures includes introducing a solution of seed crystals into an initial growth solution to form a nanostructure synthesis mixture. The initial growth solution includes a precursor material and a reducing agent in a surfactant solution. Growth of nanostructures in the nanostructure synthesis mixture is monitored during a period of anisotropic growth of the nanostructures to determine a shift from stage II growth of the nanostructures to stage III growth of the nanostructures. The shift from stage II growth to stage III growth is identified, and after identifying the shift, a second growth solution is added to the nanostructure synthesis mixture coincident in time with the shift. The second growth solution includes the precursor material and the reducing agent in the surfactant solution. |
| FILED | Tuesday, April 17, 2018 |
| APPL NO | 15/954646 |
| ART UNIT | 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0018 (20130101) B22F 9/24 (20130101) Original (OR) Class B22F 2301/255 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 11/04 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/81 (20130101) Y10S 977/762 (20130101) Y10S 977/896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759052 | Scott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Gregory P. Scott (Washington, District of Columbia); Andrew Bolkhovitinov (Reston, Virginia) |
| ABSTRACT | An apparatus and system for launching and/or capturing an unmanned aerial vehicle (UAV). The apparatus includes a moving substrate having an electromagnetic end effector and a UAV with a metallic strike plate to be attracted to the end effector when the electromagnet is activated. The system includes a movable robotic arm having a free end and a secured end; an electromagnetic end effector connected proximate to the free end of the robotic arm; a UAV with a metallic strike to be attracted and held to the electromagnetic end effector when the electromagnetic end effector is active; trajectory software configured to control a location of the free end of the robotic arm; and a control module for receiving input data, analyzing the data and using the trajectory software to control the location of and activate or deactivate the electromagnetic end effector. Also described are methods for launching and capturing the UAV. |
| FILED | Monday, July 30, 2018 |
| APPL NO | 16/049417 |
| ART UNIT | 3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1664 (20130101) Original (OR) Class B25J 9/1679 (20130101) B25J 15/0608 (20130101) Aeroplanes; Helicopters B64C 2201/08 (20130101) B64C 2201/182 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/02 (20130101) B64F 1/04 (20130101) B64F 1/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759084 | Sullivan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oceanit Laboratories, Inc. (Honolulu, Hawaii) |
| ASSIGNEE(S) | Oceanit Laboratories, Inc. (Honolulu, Hawaii) |
| INVENTOR(S) | Christopher Sullivan (Honolulu, Hawaii); Ashavani Kumar (Sunnyvale, California); Venkat Kamavaram (Honolulu, Hawaii) |
| ABSTRACT | A shock consolidation material manufacturing method involves combining a nanoscale additive and ceramic nanoparticles to create a nano-powder, compacting the nano-powder mechanically, and performing shock-wave consolidation on the compacted nano-powder. The ceramic nanoparticles may be Yttria-stabilized tetragonal Zirconia (YSZ) or Samarium doped Ceria (SDC). The nanopowder may be CNT-YSZ or SDC-Na2CO3. The shock-wave consolidation may be performed with a laser, and may involve positioning the nano-powder on a support material, placing an ablative layer over the support material and nano-powder, placing a transparent re-usable capping layer over the ablative layer, and directing laser energy at the capping layer, turning an area of the ablative layer below the capping layer into plasma and generating shock waves through the nano-powder and support material. |
| FILED | Thursday, June 16, 2016 |
| APPL NO | 15/185006 |
| ART UNIT | 1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0006 (20130101) B23K 26/009 (20130101) B23K 26/356 (20151001) B23K 26/702 (20151001) B23K 2103/52 (20180801) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759513 | Gross et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SciMax Technologies, LLC (Long Beach, New York) |
| ASSIGNEE(S) | SCIMAX TECHNOLOGIES, LLC (Long Beach, New York) |
| INVENTOR(S) | Max Gross (Long Beach, New York); Joseph Bruno (Long Beach, New York) |
| ABSTRACT | A floor panel for installation in an aircraft includes a plurality of thermoplastic C-shaped stringers, a consolidated thermoplastic deltoid filler, a thermoplastic upper facing sheet, and a thermoplastic lower facing sheet. The stringers are disposed in a parallel arrangement with one another. The deltoid filler is disposed within a longitudinally-extending notch defined by a pair of adjacent stringers. The upper facing sheet covers an upper surface of the stringers and the deltoid filler. The lower facing sheet covers a lower surface of the stringers and the deltoid filler. The stringers, the deltoid filler, and the upper and lower facing sheets are integrally consolidated forming a unitary construction. |
| FILED | Friday, June 16, 2017 |
| APPL NO | 15/625262 |
| ART UNIT | 1781 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 65/02 (20130101) Aeroplanes; Helicopters B64C 1/18 (20130101) Original (OR) Class B64C 2001/0072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759528 | Wulff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sikorsky Aircraft Corporation (Stratford, Connecticut) |
| ASSIGNEE(S) | SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut) |
| INVENTOR(S) | Ole Wulff (Antonia, Connecticut); Derek H. Geiger (Wilton, Connecticut) |
| ABSTRACT | A system and method for controlling a rotor of an aircraft is disclosed. A desired rotor speed for the rotor is received and a torque command that generates the received rotor speed is calculated. A fuel adjustment signal is calculated based on the torque command and a dynamic rotor measurement of the aircraft. The fuel adjustment signal is provided to the aircraft to track the rotor speed to the desired rotor speed. |
| FILED | Friday, September 15, 2017 |
| APPL NO | 15/705385 |
| ART UNIT | 3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/04 (20130101) B64C 27/06 (20130101) B64C 27/57 (20130101) Original (OR) Class Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 31/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759720 | Diviacchi et al. |
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| FUNDED BY |
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| APPLICANT(S) | U.S. Army Edgewood Chemical Biological Center (APG, Maryland) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Giancarlo Diviacchi (Baltimore, Maryland); Joseph A Domanico (Bel Air, Maryland); Joseph E May (Clermont, Florida); David R Redding (Jarrettsville, Maryland) |
| ABSTRACT | The present invention is directed to a novel, low-toxicity red smoke generating composition and a method of making the same, comprising at least one red dye, a coolant, an oxidizer, a non-sugar binder, and a non-sulfur particulate fuel that is also a burn-control agent having at least one particle size distribution. Preferably, the red dye comprises an anthracene or anthraquinone-based dye and the fuel comprises a sugar or mixture of sugars. |
| FILED | Thursday, September 20, 2018 |
| APPL NO | 16/136963 |
| ART UNIT | 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 23/04 (20130101) C06B 29/10 (20130101) C06B 43/00 (20130101) C06B 45/02 (20130101) Means for Generating Smoke or Mist; Gas-attack Compositions; Generation of Gas for Blasting or Propulsion C06D 3/00 (20130101) Original (OR) Class Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 1/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759750 | Abou-Gharbia et al. |
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| FUNDED BY |
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| APPLICANT(S) | Temple University Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Temple University Of The Commonwealth System Of Higher Education (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Magid A. Abou-Gharbia (Exton, Pennsylvania); Benjamin E. Blass (Eagleville, Pennsylvania); Wayne E. Childers (New Hope, Pennsylvania); Mercy Ramanjulu (King of Prussia, Pennsylvania); George C. Morton (Collegeville, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve dysregulation of glutamate homeostasis in its etiology. |
| FILED | Thursday, April 27, 2017 |
| APPL NO | 16/096830 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) A61P 25/28 (20180101) A61P 25/30 (20180101) Heterocyclic Compounds C07D 205/08 (20130101) Original (OR) Class C07D 401/06 (20130101) C07D 401/12 (20130101) C07D 403/06 (20130101) C07D 403/12 (20130101) C07D 471/04 (20130101) C07D 471/10 (20130101) C07D 487/04 (20130101) C07D 487/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759950 | Webster et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| ASSIGNEE(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| INVENTOR(S) | Dean C. Webster (Fargo, North Dakota); Madhura Pade (Fargo, North Dakota) |
| ABSTRACT | This invention relates to novel non-isocyanate siloxane-modified glycidol carbamate (GC) resins and coating compositions containing them. The non-isocyanate siloxane modified GC resins of the invention comprise the reaction product of at least one organic polyisocyanate, glycidol, and at least one bis(hydroxyl alkyl)-terminated polydimethylsiloxane. The coating compositions of the invention comprise at least one non-isocyanate siloxane modified GC resin of the invention and at least one curing agent. The invention also relates to methods of making the resins of the invention and coatings containing them. The invention also relates to a fouling-release (FR) coating system comprising the coating compositions of the invention and methods of applying said FR coating systems to substrates. The invention also relates to articles of manufacture comprising a coating composition of the invention and a method of making such articles. |
| FILED | Tuesday, February 28, 2017 |
| APPL NO | 16/076395 |
| ART UNIT | 1762 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/08 (20130101) C08G 77/70 (20130101) C08G 77/388 (20130101) C08G 77/455 (20130101) C08G 2150/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1675 (20130101) Original (OR) Class C09D 183/08 (20130101) C09D 183/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760016 | Waage |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation of State University of New York (Albany, New York) |
| INVENTOR(S) | David J. Waage (Cobleskill, New York) |
| ABSTRACT | A gasifier system includes a reactor for receiving a wet feedstock which has a base and a container rotatably connected to the base such that a rotation of the container causes a mixing of the feedstock in an interior of the reactor. The interior is bounded by the base and the container. A space between the base and the container allows an entry of oxygen into the interior. The space has a dimension such that the feedstock is fully oxidized in a combustion area adjacent the base and such that the feedstock avoids combustion in a remainder of the interior. The reactor has a longitudinal axis inclined at an inclination angle relative to a horizontal line to promote the mixing of the feedstock in the interior. |
| FILED | Tuesday, April 21, 2015 |
| APPL NO | 15/305985 |
| ART UNIT | 1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/02 (20130101) Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/005 (20130101) Original (OR) Class C10J 3/845 (20130101) C10J 2200/154 (20130101) C10J 2300/165 (20130101) C10J 2300/0923 (20130101) C10J 2300/0926 (20130101) C10J 2300/0946 (20130101) C10J 2300/0956 (20130101) C10J 2300/0959 (20130101) C10J 2300/0973 (20130101) C10J 2300/1246 (20130101) C10J 2300/1643 (20130101) C10J 2300/1807 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 20/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760046 | Gartner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zev Jordan Gartner (San Francisco, California); Jennifer S. Liu (San Francisco, California); Noel Youngho Jee (San Francisco, California); Michael E. Todhunter (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods of patterning cells on a surface of a substrate. The methods include disposing a pattern of nucleic acids on a surface of a substrate, and contacting the patterned nucleic acids under hybridization conditions with a first suspension of cells, where cells of the first suspension include cell surface-attached nucleic acids complementary to the patterned nucleic acids, and where the cell surface-attached nucleic acids hybridize to the patterned nucleic acids to pattern the cells on the surface of the substrate. Systems and kits for practicing the methods are also provided. |
| FILED | Tuesday, November 05, 2013 |
| APPL NO | 14/441453 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2219/0063 (20130101) B01J 2219/00612 (20130101) B01J 2219/00617 (20130101) B01J 2219/00626 (20130101) B01J 2219/00659 (20130101) B01J 2219/00722 (20130101) B01J 2219/00743 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) Original (OR) Class C12N 11/00 (20130101) C12N 11/06 (20130101) C12N 2533/00 (20130101) C12N 2535/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760065 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Timothy Kuan-Ta Lu (Charlestown, Massachusetts); Robert James Citorik (Kingston, New Hampshire); Mark Kyle Mimee (Cambridge, Massachusetts) |
| ABSTRACT | Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest. |
| FILED | Wednesday, September 03, 2014 |
| APPL NO | 14/475785 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760070 | Funkner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CureVac Real Estate GmbH (Tübingen, Germany) |
| ASSIGNEE(S) | CureVac Real Estate GmbH (Tübingen, Germany) |
| INVENTOR(S) | Andreas Funkner (Tübingen, Germany); Stefanie Dorner (Tübingen, Germany); Stefanie Sewing (Tübingen, Germany); Johannes Kamm (Tübingen, Germany); Norbert Broghammer (Tübingen, Germany); Thomas Ketterer (Gomaringen, Germany); Thorsten Mutzke (Reutlingen, Germany) |
| ABSTRACT | The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF). |
| FILED | Monday, May 30, 2016 |
| APPL NO | 15/580092 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Separation B01D 61/145 (20130101) B01D 71/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1017 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/02 (20130101) G01N 2030/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760145 | Dudt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Philip Dudt (North Bethesda, Maryland); Roshdy George Barsoum (McLean, Virginia) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Philip Dudt (North Bethesda, Maryland); Roshdy George Barsoum (McLean, Virginia) |
| ABSTRACT | An apparatus and method for treatment of articles, using glass failure generated pulses. The apparatus and method is directed towards the hardening and compaction of a glass-covered elongated object that is impacted by a flyer plate having a shape that is complimentary to that of the elongated object. The flyer plate is propelled by, an explosive reaction to create the impact on the glass-covered elongated object. This results in an explosive reaction that pressure-treats the elongated object, thereby causing the hardening and compaction. |
| FILED | Friday, September 29, 2017 |
| APPL NO | 15/720033 |
| ART UNIT | 3725 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 26/00 (20130101) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 10/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760442 | DiFrancesco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Michael L DiFrancesco (Waterbury, Connecticut); Conway Chuong (Manchester, Connecticut) |
| ABSTRACT | An apparatus for sealing a circumferential gap between a stationary component and a rotating member is disclosed. The rotating member is configured to rotate about a longitudinal axis and has a radially outer surface disposed at a first non-zero angle with respect to the longitudinal axis. The apparatus includes a stator disposed circumferentially about the longitudinal axis and a shoe configured for translation in a radial direction with respect to the stator. The shoe includes a circumferential surface and a plurality of protrusions extending radially inward from the circumferential surface toward the rotating member, each one of the plurality of protrusions having a length configured to maintain a clearance gap with respect to the rotating member. |
| FILED | Friday, January 12, 2018 |
| APPL NO | 15/869489 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/14 (20130101) F01D 11/20 (20130101) F01D 11/025 (20130101) Original (OR) Class Non-positive-displacement Pumps F04D 29/083 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/55 (20130101) F05D 2250/314 (20130101) F05D 2260/38 (20130101) Pistons; Cylinders; Sealings F16J 15/442 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760483 | Merry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Brian Merry (Andover, Connecticut); Gabriel L. Suciu (Glastonbury, Connecticut); James W. Norris (Monmouth, Maine) |
| ABSTRACT | A non-metallic tailcone in a tip turbine engine includes a tapered wall structure disposed about a central axis. The non-metallic tailcone is fastened to a structural frame in the aft portion of the tip turbine engine. The tip turbine engine produces a first temperature gas stream from a first output source and a second temperature gas stream from a second output source. The second temperature gas stream is a lower temperature than the first temperature gas stream. The second temperature gas stream is discharged at an inner diameter of the tip turbine engine over an outer surface of the tailcone. Discharging the cooler second temperature gas stream at the inner diameter allows a non-metallic to be used to form the tailcone. |
| FILED | Monday, October 16, 2017 |
| APPL NO | 15/784629 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/073 (20130101) Original (OR) Class Jet-propulsion Plants F02K 1/04 (20130101) F02K 3/068 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2300/603 (20130101) F05D 2300/614 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49346 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760487 | Judd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey) |
| INVENTOR(S) | Zedic Daniel Judd (Phoenix, Arizona); Yogendra Yogi Sheoran (Scottsdale, Arizona); Jennifer Ann Reich (Chandler, Arizona); Todd A. Kincheloe (Mesa, Arizona); Yates Wong (Humboldt, Arizona); Cristopher Frost (Phoenix, Arizona) |
| ABSTRACT | An inertial inlet particle separator system for a vehicle engine is provided. A separator assembly and collector assembly are coupled to the scavenge flow path and configured to receive the scavenge air. The collector inlet has a throat defining a cumulative throat area at each position along the throat length from the first throat end to the second throat end. The collector body defines a cross-sectional area associated with each position along the throat length between the first throat end and the second throat end. The collector outlet is coupled to the collector body such that scavenge air flows into the collector inlet, through the collector body, and out through the collector outlet. At a first position between the first throat end and the second throat end, the respective cross-sectional area of the collector body is greater than or equal to the respective cumulative throat area. |
| FILED | Wednesday, August 08, 2018 |
| APPL NO | 16/058627 |
| ART UNIT | 1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Separation B01D 45/04 (20130101) B01D 45/08 (20130101) B01D 45/12 (20130101) B01D 45/16 (20130101) B01D 50/002 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/05 (20130101) F02C 7/052 (20130101) Original (OR) Class F02C 7/055 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/607 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0536 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760493 | Thomas |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Michael R. Thomas (Bloomfield, Connecticut) |
| ABSTRACT | An example flow control assembly includes a door that is moved to control flow through a heat exchanger, and a pneumatic device to move the door. |
| FILED | Monday, December 15, 2014 |
| APPL NO | 15/105167 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/18 (20130101) Original (OR) Class F02C 7/185 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/57 (20130101) F05D 2260/213 (20130101) F05D 2260/606 (20130101) F05D 2270/65 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 2021/0021 (20130101) F28D 2021/0026 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/06 (20130101) F28F 27/02 (20130101) F28F 2250/06 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101) Y02T 50/676 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760494 | Giannakopoulos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Konstantinos Panagiotis Giannakopoulos (Middletown, Connecticut); Andrew C. Carmack (West Hartford, Connecticut); Mohammad G. Faisal (Palm Beach Gardens, Florida) |
| ABSTRACT | A bore basket assembly for a gas turbine engine. The assembly includes an outer cylindrical member. The assembly also includes an inner cylindrical member at least partially surrounded by the outer cylindrical member to define an annulus therebetween, one of the cylindrical members operatively coupled to an aft rotor stage, the other of the cylindrical members operatively coupled to a forward rotor stage, the cylindrical members moveable in an axially telescoping manner relative to each other. |
| FILED | Sunday, March 18, 2018 |
| APPL NO | 15/924236 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/082 (20130101) F01D 5/085 (20130101) F01D 25/125 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/06 (20130101) F02C 7/18 (20130101) Original (OR) Class F02C 9/18 (20130101) Non-positive-displacement Pumps F04D 29/321 (20130101) F04D 29/5846 (20130101) F04D 29/5853 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/35 (20130101) F05D 2240/50 (20130101) F05D 2260/205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760500 | Porter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Steven D. Porter (Wethersfield, Connecticut); Donald W. Peters (Colchester, Connecticut); James P. Bangerter (Manchester, Connecticut) |
| ABSTRACT | A seal system is provided. The seal system may comprise a first duct having an annular geometry, a second duct overlapping the first duct in a radial direction, and a seal disposed between the first duct and the second duct. The seal may comprise a groove defined by the first duct and a piston configured to slideably engage the groove. |
| FILED | Tuesday, March 06, 2018 |
| APPL NO | 15/913105 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) F02C 7/28 (20130101) Original (OR) Class Jet-propulsion Plants F02K 1/805 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/55 (20130101) F05D 2240/58 (20130101) F05D 2250/14 (20130101) F05D 2250/34 (20130101) F05D 2250/41 (20130101) F05D 2250/314 (20130101) F05D 2260/38 (20130101) F05D 2260/57 (20130101) F05D 2300/603 (20130101) F05D 2300/6034 (20130101) Pistons; Cylinders; Sealings F16J 15/3488 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760529 | Peters et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United Technologies Corporation (Hartford, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGY CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Donald W. Peters (Colchester, Connecticut); Emma J. Place (New Hartford, Connecticut) |
| ABSTRACT | A composite wear pad for being coupled to a slider block of a convergent nozzle of a gas turbine engine includes a high heat capacity composite having a resin and a plurality of carbon fibers bonded together by the resin. The composite wear pad also includes a first rod coupled to the high heat capacity composite at a first axial end of the composite wear pad such that a first end thickness. The composite wear pad also includes a second rod coupled to the high heat capacity composite at a second axial end of the composite wear pad such that the first axial end and the second axial end of the composite wear pad each have an end thickness that is greater than a middle thickness of the composite wear pad. |
| FILED | Friday, March 02, 2018 |
| APPL NO | 15/910827 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/168 (20130101) Jet-propulsion Plants F02K 1/80 (20130101) Original (OR) Class F02K 1/1223 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/128 (20130101) F05D 2260/231 (20130101) F05D 2300/44 (20130101) F05D 2300/434 (20130101) F05D 2300/603 (20130101) F05D 2300/614 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 29/001 (20130101) F16C 29/02 (20130101) F16C 33/201 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760864 | Faughn |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Jim A. Faughn (Glen Arm, Maryland) |
| ABSTRACT | A magazine, magazine assembly, magazine retrofit kit and/or portion thereof configured to provide tactile indication of magazine ammunition level. |
| FILED | Tuesday, April 09, 2019 |
| APPL NO | 16/378628 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 9/62 (20130101) Original (OR) Class F41A 9/65 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760881 | Miklaszewski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Eric J Miklaszewski (Bloomington, Indiana); Jonathan M. Dilger (Bloomington, Indiana); Travis R. Sippel (Ames, Iowa); James B. Michael (Ames, Iowa); Stuart Barkley (Ames, Iowa) |
| ABSTRACT | Exemplary systems and methods for modifying and enhancing pyrotechnic emissions and effects are provided including systems for irradiating pyrotechnic emissions using electromagnetic radiation sources with programmable electromagnetic radiation profiles. Exemplary systems include coupling an electromagnetic radiation source to a pyrotechnic device to irradiate pyrotechnic emissions or irradiating pyrotechnic emissions with an external electromagnetic radiation source. Exemplary methods include identifying a desired pyrotechnic emission output and designing an emission and effect output to meet the desired output. |
| FILED | Friday, April 13, 2018 |
| APPL NO | 15/953040 |
| ART UNIT | 3762 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 4/00 (20130101) Original (OR) Class F42B 4/04 (20130101) F42B 4/26 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/20 (20130101) H01F 27/28 (20130101) H01F 38/14 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/16 (20130101) H05H 1/46 (20130101) H05H 2001/463 (20130101) H05H 2001/466 (20130101) H05H 2001/4667 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760970 | Shaltout et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Amr Mohammad E Shaltout (West Lafayette, Indiana); Alexander Kildishev (West Lafayette, Indiana); Vladimir Shalaev (West Lafayette, Indiana); Jingjing Liu (West Lafayette, Indiana) |
| ABSTRACT | A circular dichroism spectrometer which comprises a metasurface. The metasurface has a plurality of anisotropic antennas configured to simultaneously spatially separate LCP and RCP spectral components from an incoming light beam. An optical detector array is included which detects the LCP and RCP spectral components. A transparent medium is situated between the metasurface and the optical detector array. |
| FILED | Wednesday, December 26, 2018 |
| APPL NO | 16/233036 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0224 (20130101) G01J 3/0256 (20130101) G01J 3/447 (20130101) Original (OR) Class G01J 3/2803 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/19 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761001 | Wikswo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | John P. Wikswo (Brentwood, Tennessee); Philip C. Samson (Nashville, Tennessee); Jeffrey M. Davidson (Nashville, Tennessee); Stephen R. Koch (Madison, Tennessee); Veniamin Yu Sidorov (Nashville, Tennessee) |
| ABSTRACT | A device for measuring a tension of a bio-object construct as it is being stretched that includes a microscope, a holding member for accommodating the bio-object, and a probe. The microscope includes a condenser, an objective and a stage positioned therebetween. The stage is movable along a horizontal plane. The holding member is fixable on the stage. The probe has a first end attached to the condenser, and a second end placed in the holding member. The stage operably moves such that the bio-object construct moves toward the second end of the probe and contacts with the second end of the probe, thereby causing a displacement of the second end of the probe and a displacement of the bio-object construct, which are used to measure the tension of the bio-object construct. |
| FILED | Tuesday, January 17, 2017 |
| APPL NO | 16/064151 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/20 (20130101) Original (OR) Class G01N 2203/028 (20130101) G01N 2203/0089 (20130101) G01N 2203/0094 (20130101) G01N 2203/0647 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0004 (20130101) G02B 21/08 (20130101) G02B 21/26 (20130101) G02B 21/365 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761028 | Raphael et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Marc P. Raphael (Springfield, Virginia); Joseph A. Christodoulides (Alexandria, Virginia); Jeff M. Byers (Fairfax Station, Virginia); James B. Delehanty (Washington, District of Columbia) |
| ABSTRACT | Methods and systems for determining extracellular concentration data of an analyte are disclosed. A method for determining extracellular concentration data of an analyte includes receiving sensor data from one or more arrays of functionalized plasmonic nanostructures on a localized surface plasmon resonance imaging chip in contact with a fluid containing at least one living cell for a plurality of times, determining intensity data for the one or more arrays, determining fractional occupancy based on the intensity data, and determining extracellular concentration data based on the fractional occupancy data. A system for determining extracellular concentration data of an analyte includes a LSPRi chip, a sensor component, an intensity component, a fractional occupancy component, a concentration component, and a processor to implement the components. |
| FILED | Monday, June 20, 2016 |
| APPL NO | 15/186742 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/554 (20130101) G01N 21/648 (20130101) Original (OR) Class G01N 21/6458 (20130101) G01N 33/54373 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
10761043 — Graphene-based nanopore and nanostructure devices and methods for macromolecular analysis
| US 10761043 | Drndic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marija Drndic (Philadelphia, Pennsylvania); Ken Healy (Cambridge, Massachusetts); Meni Wanunu (Chestnut Hill, Massachusetts); Christopher Ali Merchant (Baltimore, Maryland); Matthew Puster (Philadelphia, Pennsylvania); Kimberly Elizabeth Venta (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Marija Drndic (Philadelphia, Pennsylvania); Ken Healy (Cambridge, Massachusetts); Meni Wanunu (Chestnut Hill, Massachusetts); Christopher Ali Merchant (Baltimore, Maryland); Matthew Puster (Philadelphia, Pennsylvania); Kimberly Elizabeth Venta (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are graphene-based nanopore and nanostructure devices, which devices may include an insulating layer disposed atop the graphene, which can be in a planar shape or nanostructured into a ribbon or other shapes, containing a single graphene layer or several layers. Graphene layers and nanostructures can be placed nearby horizontally or stacked vertically. Also provided are related methods of fabricating and processing such devices and also methods of using such devices in macromolecular analysis. |
| FILED | Friday, July 20, 2012 |
| APPL NO | 13/553853 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/26 (20130101) Original (OR) Class G01N 33/48721 (20130101) Technical Subjects Covered by Former US Classification Y10T 156/10 (20150115) Y10T 156/1056 (20150115) Y10T 436/143333 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761152 | Leese de Escobar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Anna Leese de Escobar (Encinitas, California); Robert Lewis Fagaly (Carlsbad, California); Susan Anne Elizabeth Berggren (San Diego, California); Benjamin Jeremy Taylor (Escondido, California); Marcio Calixto de Andrade (San Diego, California) |
| ABSTRACT | A superconducting quantum interference device (SQUID) for mobile applications comprising: a superconducting flux transformer having a pickup coil and an input coil, wherein the input coil is inductively coupled to a Josephson junction; a resistive element connected in series between the pickup coil and the input coil so as to function as a high pass filter such that direct current (DC) bias current is prevented from flowing through the input coil; and a flux bias circuit electrically connected in parallel to the superconducting flux transformer between the pickup coil and the input coil so as to reduce motion-induced noise. |
| FILED | Wednesday, September 12, 2018 |
| APPL NO | 16/128969 |
| ART UNIT | 2866 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0047 (20130101) G01R 33/0356 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761176 | Tin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Steven Tin (Plymouth, Minnesota) |
| ABSTRACT | A differential signature detection system is provided. The system comprises: a target sensor, wherein the target sensor is configured to measure acoustical signals within a first narrow band around a target frequency; an offset sensor, wherein the offset sensor is configured to measure acoustical signals within a second narrow band around an offset frequency; and a controller coupled to the target sensor and the offset sensor, wherein the controller is configured to: compare a signal output of the target sensor with an output of the signal output of the offset sensor to calculate a differential measurement that comprises a difference in signal peak intensity; compare the differential measurement to a reference signal, wherein the reference signal comprises a threshold indicative of a presence of a characteristic signature peak associated with a target object; and produce an output based on the comparison between the differential measurement and the reference signal. |
| FILED | Tuesday, October 16, 2018 |
| APPL NO | 16/162276 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 1/72 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761189 | Pohl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alakai Defense Systems, Inc. (Largo, Florida) |
| ASSIGNEE(S) | Alakai Defense Systems, Inc. (Largo, Florida) |
| INVENTOR(S) | Kenneth R. Pohl (Clearwater, Florida); Christopher Neglia (Largo, Florida) |
| ABSTRACT | The present invention comprises a novel approach for determining range to a target using the inelastic scattering of light from the target and/or inelastic scattering of light from molecules between the light emitting source and the target. This is a useful approach in that the range measurement is independent of the retroreflectivity or absorptivity of the target. Using this methodology allows optical detection and rangefinding of targets which by intention or otherwise cannot be detected using conventional LIDAR rangefinding. |
| FILED | Tuesday, November 21, 2017 |
| APPL NO | 15/819963 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/49 (20130101) G01N 21/65 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4808 (20130101) Original (OR) Class G01S 7/4816 (20130101) G01S 17/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761266 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Alan Young Liu (New Orleans, Louisiana); Justin Norman (Goleta, California); Arthur Gossard (Santa Barbara, California); John Bowers (Santa Barbara, California) |
| ABSTRACT | A silicon-photonic integrated circuit comprising a direct-bandgap-semiconductor-based active optical device that is epitaxially grown on an indirect-bandgap SOI substrate (108) is disclosed. The structure of the active optical device includes an active region (120) having quantum dots (206) made of InGaAs that are embedded in one or more confinement layers (n-InP, p-InP), where the bandgap of the confinement layers is higher than that of the quantum dots. Further the confinement-layer material is preferably lattice matched to the quantum dot material in order to suppress associated crystalline defects within the material are located away from the center of its bandgap such that they suppress recombination-enhanced defect-reaction-driven degradation of the active optical device. The active optical device is epitaxially grown on a handle substrate of an SOI substrate that has a surface waveguide formed in its device layer, where the active region and the surface waveguide are at the same height above the handle wafer surface. |
| FILED | Wednesday, May 31, 2017 |
| APPL NO | 16/306740 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/131 (20130101) Original (OR) Class G02B 6/136 (20130101) G02B 2006/12078 (20130101) G02B 2006/12121 (20130101) G02B 2006/12128 (20130101) G02B 2006/12178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761268 | Beranek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | The United States Government as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Mark Beranek (Hollywood, Maryland); Nicholas Peterson (Minneapolis, Minnesota); Bradley Yost (Mechanicsville, Maryland); Michael Block (St. Leonard, Maryland); Elizabeth Meiser (Baltimore, Maryland); Amanda Cabrera (White Plains, Maryland); Frederick Lancaster (Dameron, Maryland); Justin Klock (Lexington Park, Maryland); William Boyden (Hughesville, Maryland) |
| ABSTRACT | A fiber optic mechanical splice for splicing input and output optical fiber. The splice includes a capillary tube for enclosing fiber ends of the input and output optical fiber cables, two metallic cable-splice bridging flanges for insertion onto the input and output optical fiber cable jackets, a first metallic crimping tube, a second metallic crimping tube, a first protection tube, a second protection tube, and polyurethane tape. The fibers extending from the input and output optical fibers can be frustoconically inserted into a corresponding bridging flange. The crimping tubes enclose corresponding cable ends and bridging flanges. The first protection tube encloses the crimping tubes, while the second protection tube encloses the first protection tube and the tape is disposed over the second protection tube, the bridging flanges, and the crimping tubes. |
| FILED | Monday, December 02, 2019 |
| APPL NO | 16/700294 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/255 (20130101) Original (OR) Class G02B 6/2558 (20130101) G02B 2006/12192 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761275 | Sandhu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | Micron Technology, Inc. (Boise, Idaho) |
| INVENTOR(S) | Gurtej Sandhu (Boise, Idaho) |
| ABSTRACT | The disclosed embodiments relate to an integrated circuit structure and methods of forming them in which photonic devices are formed on the back end of fabricating a CMOS semiconductor structure containing electronic devices. Doped regions associated with the photonic devices are formed using microwave annealing for dopant activation. |
| FILED | Friday, June 22, 2018 |
| APPL NO | 16/015778 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/42 (20130101) Original (OR) Class G02B 6/122 (20130101) G02B 2006/12169 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/324 (20130101) H01L 27/0617 (20130101) H01L 31/1864 (20130101) H01L 31/02327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761391 | Lentz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| INVENTOR(S) | Joshua Lentz (Niceveville, Florida) |
| ABSTRACT | A device includes a number of grating stages having a liquid crystal layer disposed between at least two substrates, where at least one is coated with a photo-alignment layer and transparent electrodes. Each grating stage may be switchably responsive to a voltage, with grating periods of each grating stage selected such that, when the voltage is applied to a grating stage and a laser beam is passed therethrough, optical energy from the laser beam in plus and minus first orders is deflected toward sides of the grating stage and optical energy from a zero order of the laser beam is allowed to pass through the grating stage. A polarization state of the laser beam may be maintained from an input through an output. Each grating stage may include a thickness selected to achromatize the laser beam through the grating stages. |
| FILED | Tuesday, August 29, 2017 |
| APPL NO | 15/688981 |
| ART UNIT | 2871 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/003 (20130101) G02B 5/18 (20130101) G02B 27/4233 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/29 (20130101) G02F 1/139 (20130101) Original (OR) Class G02F 1/292 (20130101) G02F 1/1313 (20130101) G02F 1/13363 (20130101) G02F 1/13439 (20130101) G02F 1/13471 (20130101) G02F 1/133711 (20130101) G02F 1/133788 (20130101) G02F 2001/133631 (20130101) G02F 2001/133757 (20130101) G02F 2203/04 (20130101) G02F 2203/07 (20130101) G02F 2203/22 (20130101) G02F 2203/24 (20130101) G02F 2203/48 (20130101) Pictorial Communication, e.g Television H04N 9/3164 (20130101) H04N 9/3167 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10762082 | Ackermann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Chris F. Ackermann (Fairfax, Virginia); Charles E. Beller (Baltimore, Maryland); Stephen A. Boxwell (Columbus, Ohio); Stanley J. Vernier (Grove City, Ohio) |
| ABSTRACT | A system includes a question processing circuit, an answer processing circuit, a mining circuit, and a question determination circuit. The question processing circuit is configured to receive a first question. The answer processing circuit is configured to generate a first answer set corresponding to the first question. The first answer set corresponds with one or more evidence passages. The mining circuit is configured to mine the evidence passages to identify a geospatial or temporal modifier. The question determination circuit is configured to generate a second question based on the first question and the geospatial or temporal modifier. The answer processing circuit is further configured to generate a second answer set corresponding to the second question and return a question answer set based on the second answer set to a user. |
| FILED | Thursday, January 05, 2017 |
| APPL NO | 15/399164 |
| ART UNIT | 2153 — Data Bases & File Management |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2465 (20190101) G06F 16/2477 (20190101) G06F 16/3325 (20190101) G06F 16/9537 (20190101) G06F 16/24522 (20190101) Original (OR) Class G06F 16/24578 (20190101) G06F 17/10 (20130101) Computer Systems Based on Specific Computational Models G06N 5/00 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 7/02 (20130101) Wireless Communication Networks H04W 4/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10762183 | Charan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Architecture Technology Corporation (Minneapolis, Minnesota) |
| ASSIGNEE(S) | ARCHITECTURE TECHNOLOGY CORPORATION (Minneapolis, Minnesota) |
| INVENTOR(S) | Deborah K. Charan (Minneapolis, Minnesota); Ranga Ramanujan (Medina, Minnesota) |
| ABSTRACT | In general, the techniques of this disclosure describe a computing device in a secure domain that is configured to receive, via a guard device, an authentication factor from a biometric authentication device in a non-secure domain. The biometric authentication device is in a non-secure domain, and the authentication factor comprises an identifier of a prospective user of the biometric authentication device. The computing device may then determine, based on the received authentication factor, whether the prospective user is a trusted user of the computing device based on the authentication factor. Responsive to determining that the prospective user of the biometric authentication device is the trusted user, the computing device may enable access to one or more applications on the computing device. |
| FILED | Tuesday, January 09, 2018 |
| APPL NO | 15/866046 |
| ART UNIT | 2434 — Cryptography and Security |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0402 (20130101) Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00221 (20130101) G06K 9/00557 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10762211 | Clift et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Robert Thomas Clift (King George, Virginia); Ashley L. Bowry (Vienna, Virginia); Jon T. Posch (Fredericksburg, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Robert Thomas Clift (King George, Virginia); Ashley L. Bowry (Vienna, Virginia); Jon T. Posch (Fredericksburg, Virginia) |
| ABSTRACT | A computer-implemented consolidation method is provided for identifying software vulnerability anomalies in a source code. This method includes providing a plurality of diagnostic tools; receiving the source code; selecting a subset plurality of tools; scanning the source code by the subset plurality for the anomalies to produce a diagnostic output; sorting the output by removing anomaly duplicates into a report; and saving the report into memory. Each tool among the plurality is able to detect the anomalies in software. |
| FILED | Thursday, April 12, 2018 |
| APPL NO | 15/951412 |
| ART UNIT | 2497 — Cryptography and Security |
| CURRENT CPC | Electric Digital Data Processing G06F 11/3664 (20130101) G06F 11/3692 (20130101) G06F 21/577 (20130101) Original (OR) Class G06F 2221/033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10762431 | Yeoh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Terence Yeoh (Pasadena, California); Nehal Desai (El Segundo, California) |
| ABSTRACT | Artificial intelligence (AI) techniques that map disallowed states and enable access to those states under certain conditions through a search algorithm are disclosed. In other words, scenario boundaries may be crossed by jumping from one scenario that is less desirable or even has no solution to another scenario that is more desirable. |
| FILED | Tuesday, May 01, 2018 |
| APPL NO | 15/968203 |
| ART UNIT | 2669 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/46 (20130101) G06K 9/6247 (20130101) Computer Systems Based on Specific Computational Models G06N 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10762925 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Woo K. Lee (Washington, District of Columbia); Keith E. Whitener (Washington, District of Columbia); Paul E. Sheehan (Springfield, Virginia) |
| ABSTRACT | A patterned magnetic graphene made from the steps of transferring or growing a graphene film on a substrate, functionalizing the graphene film, hydrogenating the graphene film and forming fully hydrogenated graphene, manipulating the extent of the hydrogen content by using an electron beam from a scanning electron microscope to selectively remove hydrogen, wherein the step of selectively removing hydrogen occurs under a vacuum, and forming areas of magnetic graphene and non-magnetic graphene. A ferromagnetic graphene film comprising film that has a thickness of less than two atom layers thick. |
| FILED | Wednesday, October 10, 2018 |
| APPL NO | 16/156934 |
| ART UNIT | 1785 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 5/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) Information Storage Based on Relative Movement Between Record Carrier and Transducer G11B 5/65 (20130101) G11B 5/84 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10762954 | Soykal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Öney Soykal (Alexandria, Virginia); Thomas L. Reinecke (Alexandria, Virginia); Samuel G. Carter (Waldorf, Maryland) |
| ABSTRACT | Devices and methods for the detection of magnetic fields, strain, and temperature using the spin states of a VSi− monovacancy defect in silicon carbide, as well as quantum memory devices and methods for creation of quantum memory using the spin states of a VSi− monovacancy defect in silicon carbide. |
| FILED | Friday, November 15, 2019 |
| APPL NO | 16/684673 |
| ART UNIT | 2825 — Semiconductors/Memory |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0032 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Static Stores G11C 7/22 (20130101) G11C 11/16 (20130101) G11C 11/42 (20130101) G11C 11/44 (20130101) Original (OR) Class G11C 11/161 (20130101) G11C 13/04 (20130101) G11C 13/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763447 | Kippelen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Bernard Kippelen (Atlanta, Georgia); Naoya Aizawa (Atlanta, Georgia); Canek Fuentes-Hernandez (Atlanta, Georgia); Junji Kido (Atlanta, Georgia); Seth Marder (Atlanta, Georgia); Felipe A. Larrain (Atlanta, Georgia); Wen-Fang Chou (Atlanta, Georgia); Vladimir Kolesov (Atlanta, Georgia) |
| ABSTRACT | The disclosed technology includes systems, devices, and methods associate with producing an organic semiconductor film having electrical dopant molecules distributed to a controlled depth. In an example implementation, a semiconductor device is provided. The semiconductor device can include a first substrate and an organic semiconductor film disposed on the first substrate. The organic semiconductor film includes a first region characterized by electrical dopant molecules distributed to a controlled depth with respect to a first surface of the organic semiconductor film. The semiconductor device further can include an electrode in contact with at least a portion of the first region of the organic semiconductor film. |
| FILED | Friday, June 03, 2016 |
| APPL NO | 15/735549 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/002 (20130101) H01L 51/0003 (20130101) H01L 51/0034 (20130101) H01L 51/0035 (20130101) H01L 51/0036 (20130101) H01L 51/0037 (20130101) H01L 51/0043 (20130101) H01L 51/44 (20130101) Original (OR) Class H01L 51/0047 (20130101) H01L 51/4253 (20130101) H01L 51/4293 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763500 | Parker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Joseph F. Parker (Washington, District of Columbia); Jeffrey W. Long (Alexandria, Virginia); Debra R. Rolison (Arlington, Virginia) |
| ABSTRACT | An article having a continuous network of zinc and a continuous network of void space interpenetrating the zinc network. The zinc network is a fused, monolithic structure. A method of: providing an emulsion having a zinc powder and a liquid phase; drying the emulsion to form a sponge; annealing and/or sintering the sponge to form an annealed and/or sintered sponge; heating the annealed and/or sintered sponge in an oxidizing atmosphere to form an oxidized sponge having zinc oxide on the surface of the oxidized sponge; and electrochemically reducing the zinc oxide to form a zinc metal sponge. |
| FILED | Wednesday, August 02, 2017 |
| APPL NO | 15/666724 |
| ART UNIT | 1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/30 (20130101) H01M 4/38 (20130101) Original (OR) Class H01M 4/42 (20130101) H01M 4/043 (20130101) H01M 4/48 (20130101) H01M 4/244 (20130101) H01M 4/362 (20130101) H01M 4/366 (20130101) H01M 4/0471 (20130101) H01M 4/628 (20130101) H01M 4/9016 (20130101) H01M 10/30 (20130101) H01M 12/08 (20130101) H01M 2004/021 (20130101) H01M 2004/027 (20130101) H01M 2300/0014 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763537 | Phillips et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Jonathan Phillips (Pacific Grove, California); Claudia C. Luhrs (Pacific Grove, California) |
| ABSTRACT | The disclosure provides a method a method for generating a heterogeneous carbon-bonded material using an activated carbon support a solution comprising a material precursor and a chemical agent. The material precursor is typically a salt such as SnCl2, and the chemical agent is a substance which thermally decomposes to generate reducing gases. The mixture is heated in an inert, nonreactive atmosphere to generate the reducing gases and remove surface groups from the carbon support, allowing material such as metal from the material precursor to nucleate and directly bond to the sites. The method typically utilizes high specific surface area carbon and may produce a plurality of metal particles having an average diameter of less than about 20 nm dispersed on and strongly bonded to the underlying carbon support. |
| FILED | Friday, June 16, 2017 |
| APPL NO | 15/625103 |
| ART UNIT | 1717 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 3/0272 (20130101) Non-metallic Elements; Compounds Thereof; C01B 31/10 (20130101) C01B 32/336 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/12 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/387 (20130101) H01M 4/663 (20130101) H01M 10/052 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763685 | Kfir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hadal, Inc. (Oakland, California) |
| ASSIGNEE(S) | HADAL, INC. (Oakland, California) |
| INVENTOR(S) | Ben Kfir (San Francisco, California); Doug Traeger (Oakland, California); Robert S. Damus (Alameda, California); Richard J. Rikoski (Alameda, California) |
| ABSTRACT | Systems and methods are described herein for regulating a charging rate of a battery module for an autonomous vehicle. In some aspects, the method comprises measuring a first battery cell temperature using a first temperature sensor located at a first battery cell of a plurality of batter cells in a battery module, determining whether the first battery cell temperature corresponds to a lowest temperature of the plurality of battery cells, determining a first charging rate corresponding to the first battery cell temperature, determining a first charging current and a first charging voltage corresponding to the first charging rate, and adjusting a charging current to the first charging current and a charging voltage to the first charging voltage for the battery module. |
| FILED | Thursday, June 14, 2018 |
| APPL NO | 16/008846 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/14 (20190201) B60L 53/60 (20190201) B60L 2200/32 (20130101) B60L 2240/36 (20130101) Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/001 (20130101) B63G 2008/004 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0021 (20130101) H02J 7/0091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763702 | Logan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of tha United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | John T. Logan (Alexandria, Virginia); Rick W. Kindt (Arlington, Virginia) |
| ABSTRACT | Systems and methods are provided for enabling ambient radio frequency (RF) energy to be harvested with a device. In an embodiment, wideband phased array antennas in the device efficiently harvest ambient RF energy over a broad electromagnetic spectrum, and circuitry adapts this RF energy into DC power for battery charging or energy storage. In an embodiment, the device is a modularly connected/disconnected, passive, wireless RF-to-DC adapter accessory that can ultimately be used to supply power to an electric apparatus and/or transporter. |
| FILED | Friday, May 18, 2018 |
| APPL NO | 15/983511 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/12 (20190201) B60L 53/30 (20190201) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/025 (20130101) H02J 50/20 (20160201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763787 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jianxun Zhu (New York, New York); Peter R. Kinget (Summit, New Jersey) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Jianxun Zhu (New York, New York); Peter R. Kinget (Summit, New Jersey) |
| ABSTRACT | Circuit for wireless communication are provided, the circuits comprising: a first quadrature hybrid having a first in port, a first iso port, a first cpl port, and a first thru port; a first mixer having a first input coupled to the first cpl port and having an output; a second mixer have a first input coupled to the first cpl port and having an output; a third mixer having a first input coupled to the first thru port and having an output; a fourth mixer having a first input coupled to the first thru port and having an output; and a first complex combiner having inputs coupled to the output of the first mixer, the output of the second mixer, the output of the third mixer, and the output of the fourth mixer that provides first I and Q outputs based the output of the first mixer and the output of the second mixer. |
| FILED | Tuesday, October 04, 2016 |
| APPL NO | 15/765795 |
| ART UNIT | 2849 — Electrical Circuits and Systems |
| CURRENT CPC | Modulation H03C 3/40 (20130101) Original (OR) Class Demodulation or Transference of Modulation From One Carrier to Another H03D 7/166 (20130101) Amplifiers H03F 3/19 (20130101) H03F 3/68 (20130101) H03F 3/245 (20130101) H03F 3/45475 (20130101) H03F 2200/192 (20130101) H03F 2200/198 (20130101) H03F 2200/204 (20130101) H03F 2200/294 (20130101) H03F 2200/336 (20130101) H03F 2200/405 (20130101) H03F 2200/451 (20130101) H03F 2200/534 (20130101) H03F 2200/537 (20130101) H03F 2203/45512 (20130101) H03F 2203/45522 (20130101) H03F 2203/45526 (20130101) H03F 2203/45528 (20130101) H03F 2203/45548 (20130101) H03F 2203/45591 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/38 (20130101) H03H 7/48 (20130101) H03H 7/0115 (20130101) H03H 2007/013 (20130101) Transmission H04B 1/10 (20130101) H04B 1/52 (20130101) H04B 3/32 (20130101) H04B 7/005 (20130101) H04B 7/12 (20130101) H04B 7/068 (20130101) H04B 7/0617 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763906 | Ramlall |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center, Pacific (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Sunil V. Ramlall (San Diego, California) |
| ABSTRACT | A system and method are disclosed for selecting a sampling frequency in a system that performs bandpass sampling and uses a polyphase downconverter channelizer to receive multiple RF signals. The method accounts for the frequency location of the received signals throughout the signal reception process to simplify the overall processing. The procedure finds a sampling frequency that positions all or a subset of the sampled signals such that the sampled signals fall within the input channels of the polyphase downconverter channelizer, thus simplifying processing compared to prior art methods which address the bandpass sampling and polyphase downconverter channelizer components separately. |
| FILED | Wednesday, January 22, 2020 |
| APPL NO | 16/749733 |
| ART UNIT | 2646 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Transmission H04B 1/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763961 | Newell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The John Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Katherine T. Newell (Elkridge, Maryland); Juan C. Juarez (Ellicott City, Maryland); Michelle P. O'Toole (Columbia, Maryland); Radha A. Venkat (Columbia, Maryland); Lauren S. Weiss (Baltimore, Maryland); Ryan P. DiNello-Fass (Mount Airy, Maryland) |
| ABSTRACT | A device includes an optical fiber bundle having at least one optical data fiber and at least three optical tracking fibers, a mirror package configured to direct an incoming optical beam to the optical fiber bundle, at least three detectors, each detector corresponding to one of the at least three optical tracking fibers, the at least three detectors configured to receive portions of the incoming optical beam from the corresponding optical tracking fibers and convert the portions of the incoming beam to electrical tracking signals, and a controller configured to receive the electrical tracking signals from the at least three detectors and generate a feedback control based on the electrical tracking signals to control a position of the mirror package. |
| FILED | Saturday, August 31, 2019 |
| APPL NO | 16/558049 |
| ART UNIT | 2637 — Optical Communications |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/04 (20130101) G02B 6/4202 (20130101) Transmission H04B 10/1125 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763967 | Welle |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Richard P. Welle (Huntington Beach, California) |
| ABSTRACT | An apparatus for simultaneously receiving and transmitting data in space may include a receiver configured to receive an incoming beam transmitted from a source along a receive vector between the source and the receiver. The apparatus may also include a transmitter to generate a transmitted beam along a transmit vector. The apparatus may further include a single-axis gimbal configured to rotate the transmit vector about an axis substantially perpendicular to the receive vector, and an attitude-control system configured to rotate the apparatus about an axis parallel to the receive vector or the transmit vector. |
| FILED | Wednesday, June 05, 2019 |
| APPL NO | 16/432862 |
| ART UNIT | 2637 — Optical Communications |
| CURRENT CPC | Transmission H04B 7/195 (20130101) H04B 7/18515 (20130101) H04B 10/29 (20130101) Original (OR) Class H04B 10/40 (20130101) H04B 10/66 (20130101) H04B 10/118 (20130101) H04B 10/503 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10764201 | Verbree et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DornerWorks Ltd. (Grand Rapids, Michigan) |
| ASSIGNEE(S) | DornerWorks, Ltd. (Grand Rapids, Michigan) |
| INVENTOR(S) | David Verbree (Hudsonville, Michigan); Brian Douglas (Byron Center, Michigan); Nicholas VanderStel (Ada, Michigan); Andrew DeZeeuw (Kentwood, Michigan); Juan Morales (Grand Rapids, Michigan); Eric Hughes (Hudsonville, Michigan); Corrin Meyer (Grand Rapids, Michigan); David Johnson (Grand Rapids, Michigan) |
| ABSTRACT | A communication interface controller for multiplexing data packet streams from a plurality of data packets to generate an output stream for transmission from an endpoint. The data packet streams may be multiplexed according to a QoS associated with each data packet stream and at a rate equal to or greater than a medium transmission rate. For the case of a 1 Gbps transfer rate or 125 MBps, the data packet streams may be multiplexed at a rate equal to or greater than 1 MHz, thereby providing gapless scheduling and transmission of the data packet streams. |
| FILED | Tuesday, November 27, 2018 |
| APPL NO | 16/200785 |
| ART UNIT | 2462 — Multiplex and VoIP |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 47/6215 (20130101) Original (OR) Class H04L 65/80 (20130101) H04L 69/323 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 10757937 | Cutler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Sean R. Cutler (Riverside, California); Aditya Vaidya (Riverside, California) |
| ABSTRACT | The present invention provides methods and compositions comprising agonist compounds that activate ABA receptors. In one aspect, the invention provides an agricultural formulation useful for inducing ABA responses in plant vegetative tissues, reducing abiotic stress in plants, and inhibiting germination of plant seeds. The compounds are also useful for inducing expression of ABA-responsive genes in cells that express endogenous or heterologous ABA receptors. |
| FILED | Friday, April 28, 2017 |
| APPL NO | 15/582101 |
| ART UNIT | 1616 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 41/06 (20130101) Original (OR) Class A01N 43/10 (20130101) A01N 43/32 (20130101) A01N 43/40 (20130101) A01N 43/42 (20130101) A01N 47/24 (20130101) A01N 53/00 (20130101) Acyclic or Carbocyclic Compounds C07C 311/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758136 | Kassegne et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | San Diego State University Research Foundation (SDSURF) (San Diego, California) |
| ASSIGNEE(S) | San Diego State University (SDSU) Research Foundation (San Diego, California) |
| INVENTOR(S) | Samuel Kassegne (Carlsbad, California); Pieter van Niekerk (Murrieta, California); Maria Vomero (San Diego, California) |
| ABSTRACT | Microelectromechanical system are disclosed that include at least one electrode, microelectrode or combination thereof, wherein the at least one electrode comprises a carbon material, a glassy carbon material or a combination thereof. Contemplated systems are suitable for μ-ECoG arrays. Additional microelectromechanical systems are disclosed that include at least one electrode, microelectrode or combination thereof, wherein the at least one electrode comprises a carbon material, a glassy carbon material or a combination thereof; at least one substrate, surface, layer or a combination thereof, wherein the at least one electrode, microelectrode or combination thereof is disposed on, coupled with or otherwise layered on the at least one substrate, surface, layer or a combination thereof; and at least one bump pad, wherein the at least one electrode, microelectrode or combination thereof is coupled with the at least one bump pad via at least one conductive metal. A method of making a microelectromechanical system includes patterning a polymer precursor, a carbon-containing material or a combination thereof onto a surface, a substrate, at least one layer or a combination thereof; and heating or pyrolysing the polymer precursor, a carbon-containing material or a combination thereof in order to form a glassy carbon material. Uses of microelectromechanical systems are also contemplated to measure at least one electrical property in a mammal or for electrocorticography. |
| FILED | Wednesday, September 16, 2015 |
| APPL NO | 14/855738 |
| ART UNIT | 3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0478 (20130101) A61B 5/0492 (20130101) A61B 5/04001 (20130101) Original (OR) Class A61B 5/4836 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/038 (20130101) G03F 7/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758209 | Boctor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Emad M. Boctor (Baltimore, Maryland); Russell H. Taylor (Severna Park, Maryland); Jin U. Kang (Ellicott City, Maryland) |
| ABSTRACT | An intraoperative registration and tracking system includes an optical source configured to illuminate tissue intraoperatively with electromagnetic radiation at a substantially localized spot so as to provide a photoacoustic source at the substantially localize spot, an optical imaging system configured to form an optical image of at least a portion of the tissue and to detect and determine a position of the substantially localized spot in the optical image, an ultrasound imaging system configured to form an ultrasound image of at least a portion of the tissue and to detect and determine a position of the substantially localized spot in the ultrasound image, and a registration system configured to determine a coordinate transformation that registers the optical image with the ultrasound image based at least partially on a correspondence of the spot in the optical image with the spot in the ultrasound image. |
| FILED | Monday, March 11, 2013 |
| APPL NO | 14/381374 |
| ART UNIT | 3799 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0084 (20130101) A61B 5/0095 (20130101) A61B 6/032 (20130101) A61B 6/5247 (20130101) A61B 8/14 (20130101) A61B 8/445 (20130101) A61B 8/483 (20130101) A61B 8/0841 (20130101) A61B 8/4254 (20130101) A61B 8/4416 (20130101) A61B 8/5261 (20130101) Original (OR) Class A61B 34/20 (20160201) A61B 90/37 (20160201) A61B 90/361 (20160201) A61B 2034/2063 (20160201) A61B 2034/2065 (20160201) A61B 2090/306 (20160201) A61B 2090/364 (20160201) A61B 2090/365 (20160201) A61B 2090/371 (20160201) A61B 2090/373 (20160201) A61B 2090/378 (20160201) A61B 2090/3937 (20160201) A61B 2090/3945 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758633 | Wei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | He Wei (Cambridge, Massachusetts); Oliver T. Bruns (Boston, Massachusetts); Ou Chen (Mansfield, Massachusetts); Moungi G. Bawendi (Cambridge, Massachusetts) |
| ABSTRACT | A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging. |
| FILED | Monday, October 01, 2018 |
| APPL NO | 16/149082 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/1839 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758738 | Chiel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Hillel Chiel (Cleveland, Ohio); Niloy Bhadra (Cleveland, Ohio); Mike Jenkins (Cleveland, Ohio); Emilie Lothet (Cleveland, Ohio); Tina Vrabec (Cleveland, Ohio); Kevin Kilgore (Cleveland, Ohio); Narendra Bhadra (Cleveland, Ohio); Eric Duco Jansen (Cleveland, Ohio) |
| ABSTRACT | One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal. |
| FILED | Tuesday, March 17, 2015 |
| APPL NO | 15/126610 |
| ART UNIT | 3737 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/007 (20130101) A61F 2007/0071 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/06 (20130101) A61N 1/28 (20130101) A61N 1/403 (20130101) Original (OR) Class A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 5/0622 (20130101) A61N 5/0625 (20130101) A61N 7/02 (20130101) A61N 2005/067 (20130101) A61N 2005/0659 (20130101) A61N 2007/0021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758886 | Woodbury et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Neal Woodbury (Temple, Arizona); Zhang-Gong Zhao (Tucson, Arizona) |
| ABSTRACT | Described herein are in situ synthesized arrays and methods of making them, wherein array signal sensitivity and robustness is enhanced by carrying out conditioning steps and/or generating linkers during synthesis. An array comprises a surface with a collection of features, wherein the features comprise molecules or polymers attached to the surface. In certain embodiments of the invention, carrying out conditioning steps during array synthesis can yield arrays with improved signal. In other embodiments, linkers are synthesized on the array surface prior to synthesis of functional molecules, wherein increasing linker length can correspond to an improvement in the signal generated by the array. |
| FILED | Tuesday, September 13, 2016 |
| APPL NO | 15/264426 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class B01J 2219/00432 (20130101) B01J 2219/00596 (20130101) B01J 2219/00626 (20130101) B01J 2219/00659 (20130101) B01J 2219/00675 (20130101) B01J 2219/00725 (20130101) Peptides C07K 1/047 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 50/18 (20130101) C40B 80/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759750 | Abou-Gharbia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Temple University Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Temple University Of The Commonwealth System Of Higher Education (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Magid A. Abou-Gharbia (Exton, Pennsylvania); Benjamin E. Blass (Eagleville, Pennsylvania); Wayne E. Childers (New Hope, Pennsylvania); Mercy Ramanjulu (King of Prussia, Pennsylvania); George C. Morton (Collegeville, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve dysregulation of glutamate homeostasis in its etiology. |
| FILED | Thursday, April 27, 2017 |
| APPL NO | 16/096830 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) A61P 25/28 (20180101) A61P 25/30 (20180101) Heterocyclic Compounds C07D 205/08 (20130101) Original (OR) Class C07D 401/06 (20130101) C07D 401/12 (20130101) C07D 403/06 (20130101) C07D 403/12 (20130101) C07D 471/04 (20130101) C07D 471/10 (20130101) C07D 487/04 (20130101) C07D 487/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759821 | Swarts |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Central Michigan University (Mount Pleasant, Michigan) |
| ASSIGNEE(S) | CENTRAL MICHIGAN UNIVERSITY (Mount Pleasant, Michigan) |
| INVENTOR(S) | Benjamin M. Swarts (Mount Pleasant, Michigan) |
| ABSTRACT | Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria. |
| FILED | Monday, September 11, 2017 |
| APPL NO | 15/701084 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 7/06 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) G01N 33/582 (20130101) G01N 2333/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759823 | Gervay-Hague et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jacquelyn Gervay-Hague (Davis, California); Matthew Schombs (Oxford, United Kingdom) |
| ABSTRACT | The present invention provides novel, regioselectively-acylated oligosaccharide compounds and methods for preparing them. In another aspect, the invention provides a method for preparing a selectively-acylated oligosaccharide. The method includes forming a reaction mixture containing a protected oligosaccharide and an acylating agent. The protected oligosaccharide includes at least three hydroxyl moieties and each hydroxyl moiety is protected with a silyl protecting group. The reaction mixture is formed under conditions sufficient to selectively replace at least one silyl protecting group with a —C(0)-C1_6 alkyl group, and the selectively-acylated oligosaccharide comprises at least one —C(0)-C1_6 alkyl group and at least one silyl protecting group. |
| FILED | Tuesday, August 28, 2018 |
| APPL NO | 16/115365 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 3/06 (20130101) C07H 13/04 (20130101) Original (OR) Class C07H 23/00 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/55 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759899 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| INVENTOR(S) | Eugene Y. Chen (Ft. Collins, Colorado); Jian-Bo Zhu (Ft. Collins, Colorado) |
| ABSTRACT | The invention discloses a class of new polymers, trans-ring-fused poly(4-hydroxybutyrate)s (RF-P4HB) that exhibit a unique set of properties, including robust thermal stability and mechanical strength, quantitative recyclability to the building block monomers via thermolysis and/or chemical catalysis, and convenient production from the chemical ring-opening polymerization under ambient temperature and pressure. Another unique property is the formation of crystalline stereocomplexed polymers with high melting temperature upon mixing the two enantiomeric RF-P4HB chains via stereocomplexing co-crystallization. This invention also provides the corresponding ring-fused lactone monomer structures that enable the synthesis of the RF-P4HB polymers, through trans-fusing of rings to the parent γ-butyrolactone ring. Furthermore, a polymerization or copolymerization process for the synthesis of RF-P4HB polymers and copolymers is disclosed. |
| FILED | Thursday, August 02, 2018 |
| APPL NO | 16/053225 |
| ART UNIT | 1762 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) Original (OR) Class C08G 63/823 (20130101) C08G 63/826 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/12 (20130101) C08J 2367/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760046 | Gartner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zev Jordan Gartner (San Francisco, California); Jennifer S. Liu (San Francisco, California); Noel Youngho Jee (San Francisco, California); Michael E. Todhunter (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods of patterning cells on a surface of a substrate. The methods include disposing a pattern of nucleic acids on a surface of a substrate, and contacting the patterned nucleic acids under hybridization conditions with a first suspension of cells, where cells of the first suspension include cell surface-attached nucleic acids complementary to the patterned nucleic acids, and where the cell surface-attached nucleic acids hybridize to the patterned nucleic acids to pattern the cells on the surface of the substrate. Systems and kits for practicing the methods are also provided. |
| FILED | Tuesday, November 05, 2013 |
| APPL NO | 14/441453 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2219/0063 (20130101) B01J 2219/00612 (20130101) B01J 2219/00617 (20130101) B01J 2219/00626 (20130101) B01J 2219/00659 (20130101) B01J 2219/00722 (20130101) B01J 2219/00743 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) Original (OR) Class C12N 11/00 (20130101) C12N 11/06 (20130101) C12N 2533/00 (20130101) C12N 2535/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760069 | Hagen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andrew R. Hagen (Oakland, California); Sean Poust (El Cerrito, California); Leonard Katz (Oakland, California); Jay D. Keasling (Berkeley, California) |
| ABSTRACT | The present invention provides for a polyketide synthase (PKS) capable of synthesizing a carboxylic acid, said PKS comprising a synthetic or hybrid module. The present invention also provides for a host cell comprising the PKS and when cultured produces the carboxylic acid. In some embodiments, the carboxylic acid is adipic acid. |
| FILED | Wednesday, January 10, 2018 |
| APPL NO | 15/867575 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 2319/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/16 (20130101) C08G 63/78 (20130101) C08G 69/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 9/1029 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/44 (20130101) Enzymes C12Y 203/01094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760071 | Camps |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Manel Camps (Santa Cruz, California) |
| ABSTRACT | A system for continuous mutagenesis to facilitate directed evolution, the system including DNA polymerases carrying the novel K54E point mutation, and other point mutations including I709N, A759R, D424A (herein called K54E_LF Pol I) and this methods of use to produce and detect lines where mutagenesis is continuous and does not exhibit the usual decline in mutagenesis with sequential cloning. |
| FILED | Monday, July 25, 2016 |
| APPL NO | 15/747282 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) C12N 15/70 (20130101) C12N 15/102 (20130101) C12N 15/1024 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 10/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760119 | Yoon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Jeong-Yeol Yoon (Tucson, Arizona); Dustin Harshman (San Diego, California) |
| ABSTRACT | Disclosed are devices, systems and methods of use utilizing interfacial effects enabling droplet actuation, inhibition and early sensing of molecular reactions, such as of polymerase chain reaction. |
| FILED | Friday, October 23, 2015 |
| APPL NO | 15/517028 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) B01L 7/54 (20130101) B01L 7/525 (20130101) B01L 2200/0673 (20130101) B01L 2300/185 (20130101) B01L 2300/0861 (20130101) B01L 2400/0475 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/686 (20130101) C12Q 2523/303 (20130101) C12Q 2527/101 (20130101) C12Q 2563/159 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760970 | Shaltout et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Amr Mohammad E Shaltout (West Lafayette, Indiana); Alexander Kildishev (West Lafayette, Indiana); Vladimir Shalaev (West Lafayette, Indiana); Jingjing Liu (West Lafayette, Indiana) |
| ABSTRACT | A circular dichroism spectrometer which comprises a metasurface. The metasurface has a plurality of anisotropic antennas configured to simultaneously spatially separate LCP and RCP spectral components from an incoming light beam. An optical detector array is included which detects the LCP and RCP spectral components. A transparent medium is situated between the metasurface and the optical detector array. |
| FILED | Wednesday, December 26, 2018 |
| APPL NO | 16/233036 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0224 (20130101) G01J 3/0256 (20130101) G01J 3/447 (20130101) Original (OR) Class G01J 3/2803 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/19 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
10761043 — Graphene-based nanopore and nanostructure devices and methods for macromolecular analysis
| US 10761043 | Drndic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Marija Drndic (Philadelphia, Pennsylvania); Ken Healy (Cambridge, Massachusetts); Meni Wanunu (Chestnut Hill, Massachusetts); Christopher Ali Merchant (Baltimore, Maryland); Matthew Puster (Philadelphia, Pennsylvania); Kimberly Elizabeth Venta (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Marija Drndic (Philadelphia, Pennsylvania); Ken Healy (Cambridge, Massachusetts); Meni Wanunu (Chestnut Hill, Massachusetts); Christopher Ali Merchant (Baltimore, Maryland); Matthew Puster (Philadelphia, Pennsylvania); Kimberly Elizabeth Venta (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are graphene-based nanopore and nanostructure devices, which devices may include an insulating layer disposed atop the graphene, which can be in a planar shape or nanostructured into a ribbon or other shapes, containing a single graphene layer or several layers. Graphene layers and nanostructures can be placed nearby horizontally or stacked vertically. Also provided are related methods of fabricating and processing such devices and also methods of using such devices in macromolecular analysis. |
| FILED | Friday, July 20, 2012 |
| APPL NO | 13/553853 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/26 (20130101) Original (OR) Class G01N 33/48721 (20130101) Technical Subjects Covered by Former US Classification Y10T 156/10 (20150115) Y10T 156/1056 (20150115) Y10T 436/143333 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761056 | Kang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Chi-Chih Kang (Berkeley, California); Amy E. Herr (Oakland, California); Todd A. Duncombe (Oakland, California) |
| ABSTRACT | Provided are methods for producing a separation medium, where the method includes exposing a separation medium precursor solution to light from a light source through a photomask that includes a region with varied light transmittance to produce the separation medium. Systems that find use in performing the methods, microfluidic devices that include the separation medium, as well as methods of using the microfluidic devices, are also provided. Embodiments of the present disclosure find use in a variety of different applications, including detecting whether an analyte is present in a fluid sample. |
| FILED | Wednesday, September 24, 2014 |
| APPL NO | 15/023800 |
| ART UNIT | 1767 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 2200/10 (20130101) B01L 2200/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4476 (20130101) Original (OR) Class G01N 27/44726 (20130101) G01N 27/44739 (20130101) G01N 27/44747 (20130101) G01N 27/44782 (20130101) G01N 27/44791 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 1/32 (20130101) G03F 1/50 (20130101) G03F 1/54 (20130101) G03F 7/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761242 | Mecikalski |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | John R. Mecikalski (Madison, Alabama) |
| ASSIGNEE(S) | Board of Trustees of the Unviersity of Alabama, for and on behalf of the University of Alabama in Huntsville (Huntsville, Alabama) |
| INVENTOR(S) | John R. Mecikalski (Madison, Alabama) |
| ABSTRACT | A weather forecasting system has weather forecasting logic that receives weather data from a satellite or other source, such as radar. The weather forecasting logic processes such data to identify cumulus clouds. For each cumulus cloud identified, the weather forecasting logic applies interest field tests and feeds the results into formulas derived based on measurements from current and past weather events. The model determines a score indicating the likelihood of the cumulus cloud forming precipitation and a score indicating the likelihood of the cumulus cloud forming lightning in the future within a certain time period. Based on such scores, the weather forecasting logic predicts in which geographic regions the identified cumulus cloud will produce precipitation and/or lightning during the time period. The predictions of the weather forecasting logic may then be used to provide a weather map thereby providing users with a graphical illustration of the areas. |
| FILED | Thursday, April 07, 2016 |
| APPL NO | 15/092988 |
| ART UNIT | 2829 — Semiconductors/Memory |
| CURRENT CPC | Meteorology G01W 1/10 (20130101) G01W 1/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761397 | Beach et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Geoffrey S. D. Beach (Winchester, Massachusetts); Mantao Huang (Harbin, China PRC) |
| ABSTRACT | Achieving precise, localized reversible control of optical material properties is challenging. Fortunately, electrochemical reactions and proton pumping in a solid-state system provide reversible electrical control of the solid-state system's optical properties. Applying a voltage to a thin solid electrolyte layer, such as GdOx, splits water into O2 and H+ (with charge conservation ensured by electron transfer at the electrodes) at the interface between the solid electrolyte and an electrode. The voltage drives the protons into the solid electrolyte, changing the solid electrolyte's refractive index. Reversing the polarity of the applied voltage drives the protons out of the solid electrolyte, reversing the refractive index change. This reversible electrical control can be used to implement interference color modulation, transmission modulation, and switchable plasmonics. Because the solid electrolyte can be less than 10 nanometers thick, this electrochemical control enables highly localized control of optical properties active plasmonic devices and reconfigurable metamaterials. |
| FILED | Wednesday, June 20, 2018 |
| APPL NO | 16/013543 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) G02B 6/1226 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0018 (20130101) G02F 1/19 (20130101) G02F 1/21 (20130101) G02F 1/23 (20130101) Original (OR) Class G02F 1/0316 (20130101) G02F 1/1508 (20130101) G02F 2201/34 (20130101) G02F 2202/30 (20130101) G02F 2202/36 (20130101) G02F 2203/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761419 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oumeng Zhang (St. Louis, Missouri); Matthew D. Lew (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Oumeng Zhang (St. Louis, Missouri); Matthew D. Lew (St. Louis, Missouri) |
| ABSTRACT | Systems and methods for use in tri-spot point spread function imaging are provided that include a phase mask. The phase mask includes three partitions that each include a subset of the total area that is asymmetrical to other partitions. Each partition includes a phase delay ramp aligned along a phase delay axis, and includes a gradient of phase delays. Each phase delay axis is oriented in a different direction with respect to each other. Included is a source that outputs an excitation beam into a sample containing at least one light emitter that emits a radiation pattern when illuminated. Included is at least one sensor arranged to capture at least one image of the radiation pattern and a phase mask positioned between the at least one emitter and the at least one sensor. The phase mask is configured to produce a tri-spot point spread function. |
| FILED | Tuesday, April 17, 2018 |
| APPL NO | 15/955559 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) G02B 21/0064 (20130101) G02B 21/0076 (20130101) G02B 21/361 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 1/26 (20130101) Original (OR) Class G03F 1/44 (20130101) G03F 7/70191 (20130101) G03F 9/7026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10762229 | Sion et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRIVATE MACHINES INC. (Brooklyn, New York) |
| ASSIGNEE(S) | Private Machines Inc. (Brooklyn, New York) |
| INVENTOR(S) | Radu Sion (Brooklyn, New York); Sumeet Vijay Bajaj (New York, New York); Jan Wojciech Kasiak (Seaford, New York) |
| ABSTRACT | A secure searchable and shareable remote storage system and method which utilizes client side processing to enable search capability of the stored data, allow the synchronizing of stored data between multiple discrete devices, and allow sharing of stored data between multiple discrete users. Such a remote storage system and method includes a networked remote computer server which receives and stores encrypted data and manages access thereto and a client device configured to index data to be stored, upload secured data and related information, perform searches on the stored data and related information locally, and implement cryptographic protocols which allow the stored data and related information to be synchronized with other desired client devices. Advantageously, since trusted client-side search code may directly access mostly plaintext data, it may operate orders of magnitude faster than the equivalent server code which may access encrypted data only. |
| FILED | Friday, May 06, 2016 |
| APPL NO | 15/742497 |
| ART UNIT | 2156 — Data Bases & File Management |
| CURRENT CPC | Electric Digital Data Processing G06F 16/13 (20190101) G06F 16/21 (20190101) G06F 16/178 (20190101) G06F 16/903 (20190101) G06F 16/2246 (20190101) G06F 16/2272 (20190101) G06F 21/62 (20130101) G06F 21/6218 (20130101) G06F 21/6227 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0861 (20130101) H04L 9/0891 (20130101) H04L 63/10 (20130101) H04L 63/0428 (20130101) H04L 67/1097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10762957 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Yiran Chen (Pittsburgh, Pennsylvania); Zheng Li (Pittsburgh, Pennsylvania); Hai Li (Pittsburgh, Pennsylvania) |
| ABSTRACT | A two-dimensional accessible non-volatile memory apparatus includes an array comprising a plurality of non-volatile memory cells, the array being a crossbar-based non-volatile memory structure, the memory cells being arranged in a plurality of rows and a plurality of columns. The apparatus further includes row read/write circuitry coupled to the array and structured and configured to provide read and write access to the memory cells in any one of the rows on an individual row basis, and column read/write circuitry coupled to the array and structured and configured to provide read and write access to the memory cells in any one of the columns on an individual column basis. |
| FILED | Wednesday, June 28, 2017 |
| APPL NO | 16/311809 |
| ART UNIT | 2825 — Semiconductors/Memory |
| CURRENT CPC | Static Stores G11C 7/1075 (20130101) G11C 8/10 (20130101) G11C 8/12 (20130101) G11C 8/16 (20130101) G11C 13/0002 (20130101) G11C 13/003 (20130101) Original (OR) Class G11C 13/004 (20130101) G11C 13/0007 (20130101) G11C 13/0023 (20130101) G11C 13/0026 (20130101) G11C 13/0028 (20130101) G11C 13/0069 (20130101) G11C 2213/77 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763536 | Yu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Choongho Yu (College Station, Texas); Xiong Pu (Luoyang, China PRC) |
| ABSTRACT | Embodiments of the claimed invention are directed to a device, comprising: an anode that includes a lithiated silicon-based material and a sulfur-based cathode, wherein the anode and the cathode are designed to have mesoporous structures. In certain embodiments, the sulfur-based cathode is a mesoporous carbon structure comprising sulfur within the mesopores. A further embodiment of the invention is directed to a device comprising a semi-liquid lithium-sulfur battery comprising a lithium anode and a sulfur cathode. In certain embodiments, the sulfur cathode comprises a liquid catholyte, which is housed within a reservoir that is a carbon nanotube sponge. An additional embodiment of the invention is directed to a method for producing a lithiated silicon anode and a sulfur-based cathode. |
| FILED | Wednesday, July 15, 2015 |
| APPL NO | 15/325991 |
| ART UNIT | 1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/1613 (20130101) H01M 4/38 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/663 (20130101) H01M 4/1393 (20130101) H01M 10/052 (20130101) Original (OR) Class H01M 10/0566 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763540 | Archer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Lynden A. Archer (Ithaca, New York); Shuya Wei (Henan, China PRC) |
| ABSTRACT | A sodium-ion conducting (e.g., sodium-sulfur) battery, which can be rechargeable, comprising a microporous host-sulfur composite cathode as described herein or a liquid electrolyte comprising a liquid electrolyte solvent and a liquid electrolyte salt or electrolyte additive as described herein or a combination thereof. The batteries can be used in devices such as, for example, battery packs. |
| FILED | Monday, March 06, 2017 |
| APPL NO | 16/081775 |
| ART UNIT | 1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/38 (20130101) H01M 4/362 (20130101) H01M 4/381 (20130101) H01M 4/624 (20130101) H01M 10/054 (20130101) Original (OR) Class H01M 10/0567 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
10763890 — Computational devices using thermometer coding and scaling networks on unary encoded data
| US 10763890 | Mohajer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Soheil Mohajer (Plymouth, Minnesota); Zhiheng Wang (St Paul, Minnesota); Kiarash Bazargan (Plymouth, Minnesota); Sayed Abdolrasoul Faraji (Minneapolis, Minnesota) |
| ABSTRACT | This disclosure describes techniques for performing computational operations on input unary bit streams using one or more scaling networks. In some examples, a device is configured to perform a digital computational operation, where the device includes a plurality of input wires and a plurality of output wires. Each input wire is configured to receive a respective input bit of an encoded input value, and each output wire is configured to output a respective output bit of an encoded output value. The device also includes scaling network circuitry configured to apply a function to the encoded input value by electrically routing at least one input wire of the plurality of input wires to at least two output wires of the plurality of output wires. The device can also include hybrid binary/unary computations. |
| FILED | Friday, November 09, 2018 |
| APPL NO | 16/186047 |
| ART UNIT | 2845 — Electrical Circuits and Systems |
| CURRENT CPC | Pulse Technique H03K 19/21 (20130101) Coding; Decoding; Code Conversion in General H03M 7/165 (20130101) Original (OR) Class H03M 13/2903 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10764043 | Traynor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Patrick G. Traynor (Gainesville, Florida); Bradley G. Reaves (Raleigh, North Carolina); Logan E. Blue (Gainesville, Florida); Luis Vargas (Gainesville, Florida); Hadi Abdullah (Gainesville, Florida); Thomas Shrimpton (Gainesville, Florida) |
| ABSTRACT | Systems and methods for call authentication are provided. A method can include an enrollment protocol that ensures users control the number they claim to own, a handshake protocol that mutually authenticates the calling parties, and a call integrity protocol that ensures the security of the voice channel and the content it carries. A server can act as either an endpoint or intermediary between user clients and client-server architecture can be employed. All protocols can include end-to-end cryptography and the enrollment protocol can issue a certificate that binds the identity of the client to a phone number. |
| FILED | Friday, March 30, 2018 |
| APPL NO | 15/941311 |
| ART UNIT | 2498 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0844 (20130101) Original (OR) Class H04L 9/3242 (20130101) H04L 9/3263 (20130101) H04L 9/3268 (20130101) H04L 63/0823 (20130101) H04L 65/1076 (20130101) H04L 2209/80 (20130101) Wireless Communication Networks H04W 12/04 (20130101) H04W 12/06 (20130101) H04W 12/00409 (20190101) H04W 12/1006 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 10758872 | Belfort et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, Michigan) |
| INVENTOR(S) | Georges Belfort (Slingerlands, New York); Joseph Grimaldi (Clifton Park, New York); Joseph Imbrogno (Massapequa, New York); James Kilduff (Saratoga Springs, New York); John Joseph Keating (Troy, New York) |
| ABSTRACT | The present invention relates to synthetic membranes and use of these synthetic membranes for isolation of volatile organic compounds and purification of water. The synthetic membrane includes a hydrophobic polymer layer located on a polymeric membrane support layer. The invention includes a method of isolating volatile organic compounds with the synthetic membrane by contacting a volatile organic mixture with the hydrophobic polymer layer of the synthetic membrane and removing volatile organic compounds from the polymeric membrane support layer of the synthetic membrane by a process of pervaporation. The invention also includes a method of purifying water with the synthetic membrane by contacting an ionic solution with the hydrophobic polymer layer of the synthetic membrane and removing water from the polymeric membrane support layer of the synthetic membrane by a process of reverse osmosis. The invention also relates to methods of isolating non-polar gases by gas fractionation. |
| FILED | Friday, January 03, 2020 |
| APPL NO | 16/733810 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 61/02 (20130101) B01D 61/025 (20130101) B01D 61/362 (20130101) B01D 67/0006 (20130101) B01D 67/0093 (20130101) B01D 69/02 (20130101) B01D 69/10 (20130101) B01D 69/12 (20130101) B01D 69/125 (20130101) Original (OR) Class B01D 71/28 (20130101) B01D 71/40 (20130101) B01D 71/52 (20130101) B01D 71/68 (20130101) B01D 71/78 (20130101) B01D 2257/708 (20130101) B01D 2323/08 (20130101) B01D 2323/34 (20130101) B01D 2323/38 (20130101) B01D 2323/345 (20130101) B01D 2323/385 (20130101) B01D 2325/02 (20130101) B01D 2325/26 (20130101) B01D 2325/38 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/441 (20130101) C02F 2103/08 (20130101) Acyclic or Carbocyclic Compounds C07C 29/86 (20130101) Technologies for Adaptation to Climate Change Y02A 50/235 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10758873 | Bhave et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Ramesh R. Bhave (Knoxville, Tennessee); Nicholas N. Linneen (Knoxville, Tennessee) |
| ABSTRACT | An ultrathin high permselectivity carbon molecular sieve membrane (CMSM) for industrial gas separations is provided. The CMSM includes porous metal or ceramic supports to provide superior stability at high temperatures, pressures and chemical environments. The CMSM also offers the potential for cost-effective gas processing while overcoming disadvantages found in alternative media that are fragile and susceptible to shock due to thermal cycling and prone to end-sealing problems under industrial conditions. |
| FILED | Thursday, November 16, 2017 |
| APPL NO | 15/814515 |
| ART UNIT | 1776 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 67/0067 (20130101) B01D 69/02 (20130101) B01D 69/10 (20130101) B01D 69/12 (20130101) B01D 69/125 (20130101) B01D 71/021 (20130101) B01D 71/024 (20130101) B01D 71/028 (20130101) Original (OR) Class B01D 71/40 (20130101) B01D 2256/10 (20130101) B01D 2256/12 (20130101) B01D 2256/16 (20130101) B01D 2256/18 (20130101) B01D 2256/24 (20130101) B01D 2256/245 (20130101) B01D 2257/11 (20130101) B01D 2257/102 (20130101) B01D 2257/104 (20130101) B01D 2257/108 (20130101) B01D 2257/504 (20130101) B01D 2257/7022 (20130101) B01D 2257/7025 (20130101) B01D 2325/04 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 29/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10759722 | Marker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Gas Technology Institute (Des Plaines, Illinois) |
| ASSIGNEE(S) | Gas Technology Institute (Des Plaines, Illinois) |
| INVENTOR(S) | Terry Marker (Palos Heights, Illinois); Jim Wangerow (Oak Park, Illinois); Dane Boysen (Anchorage, Alaska); Martin B. Linck (Roscoe, Illinois); Pedro Ortiz-Toral (Wheeling, Illinois) |
| ABSTRACT | Aspects of the invention are associated with the discovery of approaches for the conversion of sour natural gas streams, by conversion to liquid hydrocarbons. Particular processes and their associated apparatuses advantageously combine (i) dehydroaromatization (DHA) of methane in a gaseous feedstock, to produce aromatic hydrocarbons such as benzene, with (ii) the reaction of H2S and methane in this feedstock, to produce organic sulfur compounds such as carbon disulfide (CS2) and thiophene (C4H4S). A gaseous product having a reduced concentration of H2S is thereby generated. The aromatic hydrocarbons and organic sulfur compounds may be recovered in a liquid product. Both the gaseous and liquid products may be easily amenable to further upgrading. Other advantages of the disclosed processes and apparatuses reside in their simplicity, whereby the associated streams, including a potential gaseous recycle, generally avoid high partial pressures of H2S. |
| FILED | Thursday, January 11, 2018 |
| APPL NO | 15/867902 |
| ART UNIT | 1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 2/08 (20130101) C07C 2/42 (20130101) C07C 2/76 (20130101) Original (OR) Class C07C 2/76 (20130101) C07C 2/76 (20130101) C07C 2/76 (20130101) C07C 11/04 (20130101) C07C 15/02 (20130101) C07C 15/04 (20130101) C07C 2521/04 (20130101) C07C 2523/882 (20130101) C07C 2527/051 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 3/103 (20130101) C10L 2290/10 (20130101) C10L 2290/542 (20130101) C10L 2290/548 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760069 | Hagen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andrew R. Hagen (Oakland, California); Sean Poust (El Cerrito, California); Leonard Katz (Oakland, California); Jay D. Keasling (Berkeley, California) |
| ABSTRACT | The present invention provides for a polyketide synthase (PKS) capable of synthesizing a carboxylic acid, said PKS comprising a synthetic or hybrid module. The present invention also provides for a host cell comprising the PKS and when cultured produces the carboxylic acid. In some embodiments, the carboxylic acid is adipic acid. |
| FILED | Wednesday, January 10, 2018 |
| APPL NO | 15/867575 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 2319/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/16 (20130101) C08G 63/78 (20130101) C08G 69/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 9/1029 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/44 (20130101) Enzymes C12Y 203/01094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760103 | Bowie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | James U. Bowie (Los Angeles, California); Tyler P. Korman (Sierra Madre, California); Paul H. Opgenorth (Los Angeles, California) |
| ABSTRACT | The disclosure provides a metabolic pathway for producing a metabolite, the metabolic pathway having a co-factor regulatory system for cofactor utilization in the metabolic pathway. |
| FILED | Wednesday, October 18, 2017 |
| APPL NO | 16/342849 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0008 (20130101) C12N 9/1217 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/16 (20130101) Original (OR) Class C12P 13/06 (20130101) C12P 13/08 (20130101) Enzymes C12Y 102/01012 (20130101) C12Y 207/02003 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760148 | Plotkowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee); Iowa State University Research Foundation, Inc. (Ames, Iowa); Eck Industries Incorporated (Manitowoc, Wisconsin) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee); Iowa State University Research Foundation, Inc. (Ames, Iowa); Eck Industries Incorporated (Manitowoc, Wisconsin) |
| INVENTOR(S) | Alex J. Plotkowski (Oak Ridge, Tennessee); Orlando Rios (Oak Ridge, Tennessee); Sudarsanam Suresh Babu (Oak Ridge, Tennessee); Ryan R. Dehoff (Knoxville, Tennessee); Ryan Ott (Ames, Iowa); Zachary C. Sims (Knoxville, Tennessee); Niyanth Sridharan (Oak Ridge, Tennessee); David Weiss (Manitowoc, Wisconsin); Hunter B. Henderson (Knoxville, Tennessee) |
| ABSTRACT | Described herein are additive manufacturing methods and products made using such methods. The alloy compositions described herein are specifically selected for the additive manufacturing methods and provide products that exhibit superior mechanical properties as compared to their cast counterparts. Using the compositions and methods described herein, products that do not exhibit substantial coarsening, such as at elevated temperatures, can be obtained. The products further exhibit uniform microstructures along the print axis, thus contributing to improved strength and performance. Additives also can be used in the alloys described herein. |
| FILED | Friday, July 14, 2017 |
| APPL NO | 15/650664 |
| ART UNIT | 1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 21/007 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1055 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/354 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 1/10 (20130101) Alloys C22C 1/03 (20130101) C22C 1/0416 (20130101) C22C 21/00 (20130101) C22C 21/06 (20130101) C22C 21/08 (20130101) C22C 23/06 (20130101) Original (OR) Class C22C 28/00 (20130101) C22C 30/06 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/04 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/253 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
10760168 — Composite nanoparticles comprising a complexing ligand and methods of preparation thereof
| US 10760168 | Kandapallil et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| ASSIGNEE(S) | General Electric Company (Schenectady, New York) |
| INVENTOR(S) | Binil Itty Ipe Kandapallil (Mechanicville, New York); Lakshmi Krishnan (Clifton Park, New York); Francis Johnson (Clifton Park, New York) |
| ABSTRACT | The present invention is directed to composite nanoparticles comprising a metal, a rare earth element, and, optionally, a complexing ligand. The invention is also directed to composite nanoparticles having a core-shell structure and to processes for preparation of composite nanoparticles of the invention. |
| FILED | Tuesday, April 10, 2018 |
| APPL NO | 15/950133 |
| ART UNIT | 1788 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/00 (20130101) Original (OR) Class C25B 3/12 (20130101) Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 5/02 (20130101) C25C 7/06 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/56 (20130101) C25D 11/34 (20130101) C25D 15/00 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760169 | Borole et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| INVENTOR(S) | Abhijeet P. Borole (Knoxville, Tennessee); Alex James Lewis (Knoxville, Tennessee) |
| ABSTRACT | A method for the substantially complete conversion of hydrogenous matter to higher value product, the method comprising: (i) subjecting the hydrogenous matter to a substantially complete deconstruction process in which an aqueous phase containing a multiplicity of deconstructed compounds is produced; and (ii) contacting the aqueous phase with an anode of a microbial electrolysis cell, the anode containing a community of microbes thereon which oxidatively degrade one or more of the oxygenated organic compounds in the aqueous phase to produce protons and free electrons at the anode, wherein the protons and free electrons are transported to the cathode to produce hydrogen gas or a valuable reduced organic compound at the cathode upon application of a suitable cell potential across the anode and cathode. The invention is also directed to an apparatus for practicing the method described above. |
| FILED | Thursday, June 15, 2017 |
| APPL NO | 15/623794 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 35/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) C12P 7/16 (20130101) C12P 7/18 (20130101) C12P 7/065 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/04 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) Y02E 50/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760795 | Booten et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Charles William Booten (Arvada, Colorado); Jonathan Michael Winkler (Littleton, Colorado); David Ross Roberts (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to air conditioning systems and methods. An aspect of the present disclosure is a device that includes a housing having an external surface and defining an interior volume, a heat exchanger positioned within the interior volume, a fluid line partially positioned within the interior volume, a sleeve extending from the external surface and terminating at a distal end of the sleeve, and a fluid connector. The sleeve has an outside wall spanning a length of the sleeve and defining an internal cavity, the fluid connector is positioned at or near the distal end, a portion of the fluid line is positioned within the internal cavity, and the fluid line provides a fluid connection between the heat exchanger and the fluid connector. |
| FILED | Tuesday, October 30, 2018 |
| APPL NO | 16/175124 |
| ART UNIT | 3763 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 5/10 (20130101) F16L 11/22 (20130101) F16L 29/04 (20130101) F16L 37/32 (20130101) F16L 37/34 (20130101) Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 1/16 (20130101) F24F 1/26 (20130101) F24F 1/027 (20130101) F24F 1/32 (20130101) Original (OR) Class F24F 1/34 (20130101) F24F 13/02 (20130101) F24F 13/0209 (20130101) F24F 13/0227 (20130101) F24F 2221/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10760972 | Armijo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Kenneth M. Armijo (Albuquerque, New Mexico); Julius Yellowhair (Albuquerque, New Mexico); Richard K. Harrison (Albuquerque, New Mexico) |
| ABSTRACT | A photodiode sensor device and systems. The photodiode sensor device includes a housing portion. The housing portion includes a cylindrical enclosure. A window is disposed at a first end of the housing portion. A filter wheel is within the housing portion. A motor positioned within the housing is adjacent the filter wheel opposite the window. The motor is attached to the filter wheel. A photodiode sensor within the housing portion intermediate the first photodiode sensor and the window. The first photodiode sensor receives filtered light incident on the window and transmit a signal associated with sensed parameters of the filtered light. Also, a hemispherical dome for diffusing the light to a collimating lens has a grating, a focusing lens, and a linear detector array. An exit port transmits light to the collimating lens. The sensor array is opposite the grating for sensing the diffused light. |
| FILED | Thursday, December 07, 2017 |
| APPL NO | 15/834964 |
| ART UNIT | 2878 — Optics |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/021 (20130101) G01J 3/51 (20130101) Original (OR) Class G01J 3/0202 (20130101) G01J 3/0208 (20130101) G01J 2003/1221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761074 | Benfey et al. |
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| FUNDED BY |
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| APPLICANT(S) | Hi Fidelity Genetics, Inc. (Durham, North Carolina) |
| ASSIGNEE(S) | HI FIDELITY GENETICS, INC. (Durham, North Carolina) |
| INVENTOR(S) | Philip Benfey (Durham, North Carolina); Jesse Windle (Durham, North Carolina); Daniel Goldman (Durham, North Carolina); Jeffrey Aguilar (Durham, North Carolina); Logan Johnson (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides for an electronic sensor for detecting a root of a plant in soil, the electronic sensor that includes a first conductor plate configured to be disposed in soil, a switch, a power supply, and signal extractor. The switch is electrically coupled to the first conductor plate and is configured to switch between a first mode and a second mode. The power supply is electrically coupled to the switch and is configured to provide an electrical charge to the first conductor plate in the first mode of the switch. The signal extractor is electrically coupled to the switch and is configured to extract a signal response at the first conductor plate in the second mode of the switch. The present disclosure further provides a second conductor plate configured to be disposed in soil adjacent to and substantially parallel to the first conductor plate. The second conductor plate is electrically coupled to ground. |
| FILED | Tuesday, November 22, 2016 |
| APPL NO | 15/778195 |
| ART UNIT | 2867 — Printing/Measuring and Testing |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/04 (20130101) G01N 27/22 (20130101) G01N 27/226 (20130101) G01N 33/0098 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 15/06 (20130101) G01R 15/142 (20130101) G01R 27/02 (20130101) G01R 27/22 (20130101) G01R 27/26 (20130101) G01R 27/2605 (20130101) G01R 31/2837 (20130101) G01R 35/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761986 | Blagodurov et al. |
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| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | Sergey Blagodurov (Bellevue, Washington); Timothy E. Landreth (Hopkinton, Massachusetts); Stanley Ames Lackey, Jr. (Leominster, Massachusetts); Patrick Conway (Los Altos, California) |
| ABSTRACT | A data processing system includes a host processor, a local memory coupled to the host processor, a plurality of remote memory media, and a scalable data fabric coupled to the host processor and to the plurality of remote memory media. The scalable data fabric includes a filter for storing information indicating a location of data that is stored by the data processing system. The host processor includes a hardware sequencer coupled to the filter for selectively moving data stored by the filter to the local memory. |
| FILED | Tuesday, October 23, 2018 |
| APPL NO | 16/168315 |
| ART UNIT | 2181 — Computer Architecture and I/O |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0613 (20130101) G06F 3/0629 (20130101) G06F 3/0671 (20130101) G06F 12/0815 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763000 | Argibay et al. |
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| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Nicolas Argibay (Albuquerque, New Mexico); Michael E. Chandross (Albuquerque, New Mexico); David P. Adams (Albuquerque, New Mexico); Michael T. Dugger (Tijeras, New Mexico); Blythe G. Clark (Albuquerque, New Mexico); Brad L. Boyce (Albuquerque, New Mexico); Ping Lu (Albuquerque, New Mexico) |
| ABSTRACT | The present invention relates to metal coatings and methods thereof. In certain embodiments, the invention relates to ultra-low wear noble metal alloys, such as for use in electrical contact coatings. |
| FILED | Tuesday, May 01, 2018 |
| APPL NO | 15/968618 |
| ART UNIT | 1784 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/018 (20130101) B32B 2307/202 (20130101) B32B 2307/554 (20130101) B32B 2457/00 (20130101) Alloys C22C 5/00 (20130101) C22C 5/02 (20130101) C22C 5/04 (20130101) C22C 2200/04 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/14 (20130101) C23C 14/16 (20130101) C23C 14/18 (20130101) C23C 14/35 (20130101) C23C 14/165 (20130101) C23C 14/185 (20130101) C23C 14/5806 (20130101) C23C 28/02 (20130101) C23C 28/021 (20130101) C23C 28/023 (20130101) C23C 30/00 (20130101) C23C 30/005 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) Original (OR) Class H01B 13/0036 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/70 (20130101) Y10S 977/72 (20130101) Y10S 977/81 (20130101) Y10S 977/755 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/26 (20150115) Y10T 428/265 (20150115) Y10T 428/2495 (20150115) Y10T 428/12868 (20150115) Y10T 428/12875 (20150115) Y10T 428/12889 (20150115) Y10T 428/12896 (20150115) Y10T 428/12903 (20150115) Y10T 428/12944 (20150115) Y10T 428/24967 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763005 | Celebrese et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| INVENTOR(S) | Christopher Celebrese (Niskayuna, New York); Lili Zhang (Niskayuna, New York); Wei Zhang (Niskayuna, New York); Anil Duggal (Niskayuna, New York); Weijun Yin (Niskayuna, New York) |
| ABSTRACT | An insulative assembly includes an insulative mica-based carrier film and first and second resistive grading layers joined to opposite sides of the mica-based carrier film. The first resistive material layer is configured to engage one or more conductors and insulate the one or more conductors from at least one other conductor. A method for creating an insulative assembly for one or more conductors includes obtaining an insulative mica-based carrier film, depositing a first resistive grading layer on a first side of the mica-based carrier film, and depositing a second resistive grading layer on an opposite, second first side of the mica-based carrier film. |
| FILED | Monday, May 06, 2019 |
| APPL NO | 16/404381 |
| ART UNIT | 2847 — Electrical Circuits and Systems |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 19/048 (20130101) B32B 2315/10 (20130101) B32B 2367/00 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 3/04 (20130101) Original (OR) Class H01B 3/30 (20130101) H01B 13/06 (20130101) H01B 13/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763038 | Deligianni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Hariklia Deligianni (Alpine, New Jersey); William J. Gallagher (Ardsley, New York); Sathana Kitayaporn (Portland, Oregon); Eugene J. O'Sullivan (Nyack, New York); Lubomyr T. Romankiw (Briancliff Manor, New York); Naigang Wang (Ossining, New York); Joonah Yoon (Fishkill, New York) |
| ABSTRACT | A technique relates to a method of forming a laminated multilayer magnetic structure. An adhesion layer is deposited on a substrate. A magnetic seed layer is deposited on top of the adhesion layer. Magnetic layers and non-magnetic spacer layers are alternatingly deposited such that an even number of the magnetic layers is deposited while an odd number of the non-magnetic spacer layers is deposited. The odd number is one less than the even number. Every two of the magnetic layers is separated by one of the non-magnetic spacer layers. The first of the magnetic layers is deposited on the magnetic seed layer, and the magnetic layers each have a thickness less than 500 nanometers. |
| FILED | Tuesday, November 24, 2015 |
| APPL NO | 14/950364 |
| ART UNIT | 1712 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 5/003 (20130101) H01F 10/3204 (20130101) H01F 41/043 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763376 | Frost et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | John S. Frost (Oak Park, California); Randolph J. Brandt (Palmdale, California); Peter Hebert (Glendale, California); Omar Al Taher (Los Angeles, California) |
| ASSIGNEE(S) | THE BOEING COMPANY (Chicago, Illinois) |
| INVENTOR(S) | John S. Frost (Oak Park, California); Randolph J. Brandt (Palmdale, California); Peter Hebert (Glendale, California); Omar Al Taher (Los Angeles, California) |
| ABSTRACT | A method including forming an interconnect in a metal member. The interconnect includes multiple repeating, nested V-shaped structures forming a continuous central portion. A vertex of each of the multiple repeating, nested V-shaped structures adjoins a next vertex of a next V-shaped structure of the multiple repeating, nested V-shaped structures. The method further includes separating the interconnect from the metal member. |
| FILED | Wednesday, September 02, 2015 |
| APPL NO | 14/843181 |
| ART UNIT | 3729 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/02008 (20130101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 43/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763491 | Takeuchi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for the State University of New York (Albany, New York) |
| INVENTOR(S) | Kenneth Takeuchi (South Setauket, New York); Esther Takeuchi (South Setauket, New York); Amy Marschilok (Setauket, New York) |
| ABSTRACT | Preparation, characterization, and an electrochemical study of Mg0.1V2O5 prepared by a novel sol-gel method with no high-temperature post-processing are disclosed. Cyclic voltammetry showed the material to be quasi-reversible, with improved kinetics in an acetonitrile-, relative to a carbonate-, based electrolyte. Galvanostatic test data under a C/10 discharge showed a delivered capacity >250 mAh/g over several cycles. Based on these results, a magnesium anode battery, as disclosed, would yield an average operating voltage ˜3.2 Volts with an energy density ˜800 mWh/g for the cathode material, making the newly synthesized material a viable cathode material for secondary magnesium batteries. |
| FILED | Monday, March 30, 2015 |
| APPL NO | 15/301307 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 31/00 (20130101) C01G 45/1221 (20130101) C01G 49/0036 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2004/03 (20130101) C01P 2006/12 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/48 (20130101) H01M 4/049 (20130101) Original (OR) Class H01M 4/50 (20130101) H01M 4/52 (20130101) H01M 4/5825 (20130101) H01M 10/052 (20130101) H01M 10/054 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763529 | Ghezel-Ayagh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FuelCell Energy, Inc. (Danbury, Connecticut) |
| ASSIGNEE(S) | FuelCell Energy, Inc. (Danbury, Connecticut) |
| INVENTOR(S) | Hossein Ghezel-Ayagh (New Milford, Connecticut); James B. Walzak (Danbury, Connecticut) |
| ABSTRACT | A fuel cell system includes a fuel cell having an anode configured to receive anode feed gas and output anode exhaust, and a cathode configured to receive cathode feed gas and output cathode exhaust. The system further includes a pressurizing assembly downstream from the anode and an oxidizer downstream from the anode. The cathode feed gas is the anode exhaust that has been compressed in the pressurizing assembly and reacted with air in the oxidizer. |
| FILED | Thursday, May 17, 2018 |
| APPL NO | 15/983005 |
| ART UNIT | 1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0606 (20130101) Original (OR) Class H01M 8/0662 (20130101) H01M 8/04104 (20130101) H01M 8/04111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763612 | Soroka et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Ryan Michael Soroka (Overland Park, Kansas); David William Lindbloom (Lees Summit, Missouri) |
| ABSTRACT | An electronic sealing system for sealing and shielding an electronic connector from detrimental liquid cleaners that are applied with or without pressure. The electronic sealing system includes a U-shaped holder, a gasket frame, a gasket, a top plate, and several fasteners. The U-shaped holder cradles the electronic connector. The gasket frame abuts a top side of the holder and includes an aperture. The gasket engages a portion of the connector via the aperture. The top plate abuts the gasket frame opposite the holder so as to encapsulate the gasket over the aperture and hence over a portion of the electronic connector. The fasteners secure the U-shaped holder, gasket frame, and top plate together so that the electronic connector is secured with the holder and so that a portion of the electronic connector is sealed via the gasket. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 16/545692 |
| ART UNIT | 2833 — Electrical Circuits and Systems |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 11/284 (20130101) H01R 13/4367 (20130101) H01R 13/5208 (20130101) H01R 13/5213 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 10759140 | Miller |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as Represented by the Admin of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Sandi Miller (Northfield, Ohio) |
| ABSTRACT | A polymer matrix composite includes layers that alternate between a thin carbon fiber veil layer and a thicker base carbon fiber reinforcement layer. Each veil is coated with conductive carbon nanotubes (CNTs) prior to being added as a laminate layer. Epoxy resin fixes CNTs extended into adjacent reinforcement layers, which results in a composite improved in interlaminar strength, fracture toughness, and impact resistance. Thermal and electrical conductivity are also improved due to the conductive CNTs bridging the resin-insulating interlayer region. As the fuzzy fiber veil is not relied on to provide strength or stiffness to the composite structure, any damage to the veil will not affect composite integrity. Also, as the CNT growth is not on a replacement section of reinforcement layer, the composite avoids pitfalls of strength degradation, reinforcing phase continuity disruption, and residual stress introduction. |
| FILED | Monday, May 12, 2014 |
| APPL NO | 14/275144 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/022 (20130101) Original (OR) Class B32B 37/144 (20130101) B32B 2305/08 (20130101) B32B 2307/202 (20130101) B32B 2307/302 (20130101) B32B 2309/105 (20130101) B32B 2311/08 (20130101) B32B 2311/12 (20130101) B32B 2311/22 (20130101) B32B 2313/04 (20130101) B32B 2398/00 (20130101) B32B 2605/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761020 | Vasudev |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Ramabhadran Vasudev (Pasadena, California) |
| ABSTRACT | Spectroscopic apparatus and methods incorporating a gas sensor configured to detect low concentration gases, including gases that are hazardous volatiles are provided. Low concentration gases can comprise gases where detection of concentrations on the order of parts-per-million (ppm), and in many embodiments part-per-billion (ppb) is required. The gas may be a species, such as, for example hydrogen sulfide (H2S) that may be produced in drilling and/or volcanic eruptions. The spectroscopic apparatus and methods are configured to operate in particular atmospheres where gas detection can be challenging, such as in ambient air and/or in space where various contaminants may be present. The spectroscopic apparatus and methods may incorporate a long path length detector, such as, for example, a cavity-enhanced absorption spectrometer. The methods and apparatus further incorporate a wavelength modulation technique to improve the signal-to-noise ratio. |
| FILED | Thursday, September 01, 2016 |
| APPL NO | 15/752877 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/42 (20130101) G01J 2003/423 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/031 (20130101) G01N 21/39 (20130101) Original (OR) Class G01N 2021/391 (20130101) G01N 2201/0698 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763587 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Mau-Chung Frank Chang (Los Angeles, California); Yanghyo Kim (Los Angeles, California); Adrian Tang (Pasadena, California); Nacer Chahat (Pasadena, California) |
| ABSTRACT | A system, apparatus and method are disclosed for communicating between a short range wireless (WLAN) user device, such as a wearable, phone, or tablet, with a base station. Traditional low power communication (e.g., WLAN, WiFi, Bluetooth, cellular links, etc.) involve an inefficient amplification process of a signal from the WLAN user to the base station, whereby significant power must be expended in the WLAN user device making it unsuitable in many applications. A reflector link paradigm is disclosed in which the user device communicates by modulating the extent of signal reflected back to the base station. An enhanced reflector is also disclosed which overcomes adverse effects of ambient reflections. |
| FILED | Monday, January 16, 2017 |
| APPL NO | 15/407170 |
| ART UNIT | 2649 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/246 (20130101) H01Q 1/273 (20130101) H01Q 1/2291 (20130101) H01Q 3/26 (20130101) H01Q 15/14 (20130101) Original (OR) Class Transmission H04B 1/385 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 10764067 | Lewison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Karen Pomian Lewison (Carmichael, California); Francisco Corella (Carmichael, California) |
| ASSIGNEE(S) | Pomian and Corella, LLC (Sacramento, California) |
| INVENTOR(S) | Karen Pomian Lewison (Carmichael, California); Francisco Corella (Carmichael, California) |
| ABSTRACT | An on-ledger certificate authority operates a node of a distributed ledger that controls a certificate issuance store and a certificate revocation store. When the certificate authority issues a certificate, the node issues a ledger transaction with an instruction to store a validation hash of the certificate in the issuance store, and when a certificate is revoked, a ledger transaction with an instruction to store the serial number of the certificate in the revocation store. As such transactions propagate throughout the ledger, the instructions are executed by on-ledger verifiers in their local replicas of the stores. An on-ledger verifier validates a certificate by verifying that its serial number is not in the revocation store while its validation hash is in the verifier's replica of the issuance store. |
| FILED | Thursday, May 18, 2017 |
| APPL NO | 15/599249 |
| ART UNIT | 2431 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/14 (20130101) H04L 9/30 (20130101) H04L 9/0643 (20130101) H04L 9/3236 (20130101) H04L 9/3268 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10764077 | Mumme et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAM Laboratories, Inc. (San Diego, California) |
| ASSIGNEE(S) | RAM Laboratories, Inc. (San Diego, California) |
| INVENTOR(S) | Dean C. Mumme (San Marcos, California); Robert M. McGraw (Del Mar, California); Richard A. MacDonald (San Diego, California) |
| ABSTRACT | An automated method that generates crowd-sourced event notifications includes: retrieving sensor data from mobile devices; detecting events based on the retrieved sensor data; and generating a set of summary nodes based on the events, where each summary node is associated with multiple events. A system that generates crowd-sourced event notifications includes: multiple mobile devices, each having at least one sensor, each mobile device identifies events using calculations based on sensor data and generates a notification for each identified event; and an analytics server that generates a set of summary nodes based on the identified events, each summary node associated with multiple events. An automated method that generates event notifications includes: retrieving sensor data; calculating a set of statistical values based on the sensor data; comparing the statistical values to at least one threshold; and generating an event notification when the threshold is exceeded by any of the statistical values. |
| FILED | Monday, July 24, 2017 |
| APPL NO | 15/658315 |
| ART UNIT | 2424 — Cable and Television |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 25/00 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 12/1895 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/029 (20180201) H04W 12/02 (20130101) H04W 12/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 10761001 | Wikswo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | John P. Wikswo (Brentwood, Tennessee); Philip C. Samson (Nashville, Tennessee); Jeffrey M. Davidson (Nashville, Tennessee); Stephen R. Koch (Madison, Tennessee); Veniamin Yu Sidorov (Nashville, Tennessee) |
| ABSTRACT | A device for measuring a tension of a bio-object construct as it is being stretched that includes a microscope, a holding member for accommodating the bio-object, and a probe. The microscope includes a condenser, an objective and a stage positioned therebetween. The stage is movable along a horizontal plane. The holding member is fixable on the stage. The probe has a first end attached to the condenser, and a second end placed in the holding member. The stage operably moves such that the bio-object construct moves toward the second end of the probe and contacts with the second end of the probe, thereby causing a displacement of the second end of the probe and a displacement of the bio-object construct, which are used to measure the tension of the bio-object construct. |
| FILED | Tuesday, January 17, 2017 |
| APPL NO | 16/064151 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/20 (20130101) Original (OR) Class G01N 2203/028 (20130101) G01N 2203/0089 (20130101) G01N 2203/0094 (20130101) G01N 2203/0647 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0004 (20130101) G02B 21/08 (20130101) G02B 21/26 (20130101) G02B 21/365 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US D894899 | Cooper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Goverment as represented by the Department of Veterans Affairs (Washington, District of Columbia); University of Pittsburgh Of The Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); The University of Pittsburgh Of The Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Rory A. Cooper (Gibsonia, Pennsylvania); Garrett Grindle (Pittsburgh, Pennsylvania); Zak Anzelone (Blairsville, Pennsylvania); Aaron Anderson (Pittsburgh, Pennsylvania) |
| ABSTRACT | |
| FILED | Friday, March 29, 2019 |
| APPL NO | 29/685637 |
| ART UNIT | 2917 — Design |
| CURRENT CPC | Recording, communication, or information retrieval equipment D14/402 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 10761002 | Foecke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Gaithersburg, Maryland) |
| INVENTOR(S) | Timothy J Foecke (Damascus, Maryland); Edward Pompa (Hagerstown, Maryland); Matthias J Merzkirch (Rockville, Maryland) |
| ABSTRACT | A shear loader subjects a shear load on a sample and includes: a first shearer including: a first shearing face that provides a shearing plane; a first mating face; and a first knife edge; a second shearer including: a second shearing face; a second mating face; and a second knife edge, the first shearer and the second shearer having relative motion to provide the shear load to the sample; a first load cell; and a second load cell, the first load cell and the second load cell having relative motion in a load direction that is orthogonal to the shearing plane and orthogonal to the shear direction, such that relative motion of the first load cell and the second load cell along the load direction subjects the sample to a side load along the load direction; and a sample region that receives sample bounded by the mating faces and load faces. |
| FILED | Monday, May 13, 2019 |
| APPL NO | 16/409946 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 10760872 | Vabnick |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Federal Bureau of Investigation (Washington, District of Columbia) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE FEDERAL BUREAU OF INVESTIGATION DEPARTMENT OF JUSTICE (Washington, District of Columbia) |
| INVENTOR(S) | Ian B. Vabnick (Quantico, Virginia) |
| ABSTRACT | Provided herein are fluid jet enhancement adapters for use with a propellant driven disrupter. The adapter may comprise: a first end operably connected to a muzzle end of a propellant driven disrupter barrel and a second end, wherein a longitudinal region extends between the first end and the second end. The longitudinal region has: a longitudinal region inner surface that defines a longitudinal region lumen; a longitudinal region outer surface opposably facing the longitudinal region inner surface, with a longitudinal region wall having a wall thickness that separates the longitudinal region inner surface from the longitudinal region outer surface. The longitudinal region lumen has a first end inner diameter that is substantially equivalent to a muzzle inner diameter. The longitudinal region wall forms a continuous surface that radially isolates the longitudinal region lumen from a surrounding environment. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 16/570589 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Weapons for Projecting Missiles Without Use of Explosive or Combustible Propellant Charge; Weapons Not Otherwise Provided for F41B 9/0046 (20130101) F41B 9/0075 (20130101) Original (OR) Class Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 33/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 10759681 | Viswanathan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| INVENTOR(S) | Tito Viswanathan (Little Rock, Arkansas) |
| ABSTRACT | The present disclosure relates to water purification compositions and the method of producing the same. Specifically, the present disclosure relates to compositions containing a substrate that has hydroxyl, thiol, carboxyl or amino groups, a metal oxide, and a carboxylic acid compound, and the method of producing the same. The composition is useful for the removal of soluble phosphorus, selenium, fluoride, arsenic and other heavy metal contaminants that may be present in water. The composition could be of use in numerous fields, including but not limited to, oil and gas, mining, storm water, agricultural runoffs, municipal wastewater, and industrial wastewater. |
| FILED | Thursday, June 28, 2018 |
| APPL NO | 16/021462 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/0203 (20130101) B01J 41/09 (20170101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/42 (20130101) Original (OR) Class C02F 1/281 (20130101) C02F 1/288 (20130101) C02F 2001/422 (20130101) C02F 2101/14 (20130101) C02F 2101/20 (20130101) C02F 2101/103 (20130101) C02F 2101/105 (20130101) C02F 2101/106 (20130101) C02F 2103/001 (20130101) C02F 2103/10 (20130101) C02F 2305/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 10764067 | Lewison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Karen Pomian Lewison (Carmichael, California); Francisco Corella (Carmichael, California) |
| ASSIGNEE(S) | Pomian and Corella, LLC (Sacramento, California) |
| INVENTOR(S) | Karen Pomian Lewison (Carmichael, California); Francisco Corella (Carmichael, California) |
| ABSTRACT | An on-ledger certificate authority operates a node of a distributed ledger that controls a certificate issuance store and a certificate revocation store. When the certificate authority issues a certificate, the node issues a ledger transaction with an instruction to store a validation hash of the certificate in the issuance store, and when a certificate is revoked, a ledger transaction with an instruction to store the serial number of the certificate in the revocation store. As such transactions propagate throughout the ledger, the instructions are executed by on-ledger verifiers in their local replicas of the stores. An on-ledger verifier validates a certificate by verifying that its serial number is not in the revocation store while its validation hash is in the verifier's replica of the issuance store. |
| FILED | Thursday, May 18, 2017 |
| APPL NO | 15/599249 |
| ART UNIT | 2431 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/14 (20130101) H04L 9/30 (20130101) H04L 9/0643 (20130101) H04L 9/3236 (20130101) H04L 9/3268 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 10762731 | McLellan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | United States Postal Service (Washington, District of Columbia) |
| INVENTOR(S) | Charles P. McLellan (Sterling, Virginia); Gabriel Michael Yessin (Vienna, Virginia); William Albert Tartal (Baltimore, Maryland) |
| ABSTRACT | Embodiments of a system and method for using a mobile device to assist with the efficient and secure delivery of item. The mobile device can assist an item deliver to lock or unlock secure item delivery receptacles. The mobile device can also notify an item deliverer about particular delivery conditions associated with particular delivery endpoints. The mobile device can further help the item deliverer to determine whether or not he or she is delivering the item to the correct location. |
| FILED | Tuesday, June 12, 2018 |
| APPL NO | 16/006595 |
| ART UNIT | 2683 — Telemetry and Code Generation Vehicles and System Alarms |
| CURRENT CPC | Locks; Accessories Therefor; Handcuffs E05B 47/00 (20130101) E05B 2047/0072 (20130101) Electric Digital Data Processing G06F 21/44 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/083 (20130101) G06Q 50/32 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 9/00571 (20130101) G07C 9/00896 (20130101) Original (OR) Class G07C 2009/0092 (20130101) G07C 2009/00769 (20130101) G07C 2009/00984 (20130101) G07C 2209/63 (20130101) Wireless Communication Networks H04W 4/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 10759051 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | GENERAL ELECTRIC COMPANY (Niskayuna, New York) |
| INVENTOR(S) | Huan Tan (Clifton Park, New York); Weston Blaine Griffin (Niskayuna, New York); Lynn Ann DeRose (Gloversville, New York); Yi Xu (Menlo Park, California); Ying Mao (Burlingame, California); Balajee Kannan (Clifton Park, New York) |
| ABSTRACT | The present approach relates to integrated planning of robot navigation and manipulator motion in performing tasks. In particular, as discussed herein sensor information, such as visual information, may be used for the robot to locate a target object when it arrives at a working location. Adjustments may be made based on this information that may include moving the robot and planning a manipulator arm motion. |
| FILED | Monday, April 23, 2018 |
| APPL NO | 15/960272 |
| ART UNIT | 3651 — Material and Article Handling |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/162 (20130101) B25J 9/1664 (20130101) Original (OR) Class B25J 9/1697 (20130101) B25J 15/0004 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0212 (20130101) G05D 1/0246 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/09 (20130101) Y10S 901/39 (20130101) Y10S 901/47 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761032 | Havener et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Nuclear Operations Group, Inc. (Lynchburg, Virginia); BWXT NOG Technologies, Inc. (Lynchburg, Virginia); Aaron C. Havener (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | BWXT Nuclear Operations Group, Inc. (Lynchburg, Virginia); BWXT NOG Technologies, Inc. (Lynchburg, Virginia) |
| INVENTOR(S) | Aaron C. Havener (Pittsburgh, Pennsylvania); James D. Jogerst (Forest, Virginia); Thomas C. Mohr (Forest, Virginia); Keith B. Rider (Prospect, Virginia) |
| ABSTRACT | Methods of and apparatus for inspecting composite layers of a first material formed on a second material are provided including providing an illumination source, illuminating at least a portion of the composite at the layer, receiving light reflected from the sample, determining a spectral response from the received light, and comparing the received spectral response to an expected spectral response. |
| FILED | Tuesday, February 26, 2019 |
| APPL NO | 16/286370 |
| ART UNIT | 2882 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/94 (20130101) G01N 21/8806 (20130101) Original (OR) Class G01N 2021/8812 (20130101) G01N 2021/8835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10761307 | Miller |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Kirk A. Miller (Dallas, Texas) |
| ABSTRACT | An optical system (e.g., a telescope) comprising an optical assembly that reflects and refracts light rays through a single window about an optical path to a detector. A field-of-view switch assembly comprises a mount, having a pair of diverter mirrors, movably coupled to the optical assembly and being selectively movable between a non-bypass position and a bypass position. The diverter mirrors bypass a first field-of-view and translate a second field-of-view (both through the single window) when moved from the non-bypass position to the bypass position to redirect the optical path. The diverter mirrors straddle the optical path in the non-bypass position. A dynamic shutter shields the second diverter mirror and exposes the second diverter mirror when moved between non-bypass and bypass positions. A four-bar linkage mechanism rotates the mount with an on-board motor and a torsional shaft to absorb impact forces. Associated methods are provided for facilitating switching between fields-of-view. |
| FILED | Tuesday, December 06, 2016 |
| APPL NO | 15/370766 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 7/1827 (20130101) G02B 17/0694 (20130101) G02B 17/0808 (20130101) G02B 17/0896 (20130101) Original (OR) Class G02B 23/06 (20130101) G02B 23/16 (20130101) Pictorial Communication, e.g Television H04N 5/2259 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10763419 | Kirby et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christopher F. Kirby (Gambrills, Maryland); Vivien M. Luu (Linthicum, Maryland); Michael Rennie (Ashland, Virginia); Sean R. McLaughlin (Severn, Maryland) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia) |
| INVENTOR(S) | Christopher F. Kirby (Gambrills, Maryland); Vivien M. Luu (Linthicum, Maryland); Michael Rennie (Ashland, Virginia); Sean R. McLaughlin (Severn, Maryland) |
| ABSTRACT | A method of forming a superconductor interconnect structure is disclosed. The method includes forming a dielectric layer overlying a substrate, forming an interconnect opening in the dielectric layer, and moving the substrate to a deposition chamber. The method further includes depositing a superconducting metal in the interconnect opening, by performing a series of superconducting deposition and cooling processes to maintain a chamber temperature at or below a predetermined temperature until the superconducting metal has a desired thickness, to form a superconducting element in the superconductor interconnect structure. |
| FILED | Friday, June 02, 2017 |
| APPL NO | 15/612326 |
| ART UNIT | 2813 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02063 (20130101) H01L 21/2855 (20130101) H01L 21/7684 (20130101) H01L 21/76807 (20130101) H01L 21/76814 (20130101) H01L 21/76877 (20130101) H01L 21/76879 (20130101) H01L 21/76891 (20130101) H01L 23/5226 (20130101) H01L 23/53285 (20130101) H01L 39/2406 (20130101) Original (OR) Class H01L 39/2445 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 10764817 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel IP Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel IP Corporation (Santa Clara, California) |
| INVENTOR(S) | Rui Huang (Beijing, China PRC); Yang Tang (Pleasanton, California) |
| ABSTRACT | Machine-readable media, methods, apparatus and system for discovery reference signal measurement in a license assisted access scenario are disclosed. In some embodiments, an apparatus for a user equipment (UE), comprising a control circuitry to: perform, in response to a discovery reference signal (DRS) based measurement request, a single DRS based measurement or multiple DRS based measurements, based at least in part on a measurement related information element (IE), wherein the measurement related IE comprises an indication of whether the single DRS based measurement or the multiple DRS based measurements associated with a license assisted access (LAA) scenario are to be performed; and, generate a DRS based measurement report, wherein if the measurement related IE indicates the multiple DRS based measurements, the DRS based measurement report further comprises an average DRS based measurement result of the multiple DRS based measurements. |
| FILED | Friday, May 27, 2016 |
| APPL NO | 16/069149 |
| ART UNIT | 2472 — Multiplex and VoIP |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0023 (20130101) H04L 5/0048 (20130101) H04L 5/0091 (20130101) Wireless Communication Networks H04W 16/14 (20130101) H04W 24/10 (20130101) H04W 48/16 (20130101) Original (OR) Class H04W 76/11 (20180201) H04W 76/27 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, September 01, 2020.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2020/fedinvent-patents-20200901.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page