FedInvent™ Patents

Patent Details for Tuesday, September 08, 2020

This page was updated on Monday, March 27, 2023 at 06:10 AM GMT

Department of Health and Human Services (HHS)

10765336 — System and method for planning a patient-specific cardiac procedure

US 10765336	Trayanova et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Natalia A. Trayanova (Baltimore, Maryland); Henry R. Halperin (Baltimore, Maryland); Hermenegild Arevalo (Baltimore, Maryland); Jason Constantino (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Natalia A. Trayanova (Baltimore, Maryland); Henry R. Halperin (Baltimore, Maryland); Hermenegild Arevalo (Baltimore, Maryland); Jason Constantino (Baltimore, Maryland)
ABSTRACT	A method of planning a patient-specific cardiac procedure according to an embodiment of the current invention includes receiving three-dimensional imaging data of a patient's heart, simulating at least one of electrophysiological or electromechanical activity of at least a portion of the patient's heart using the three-dimensional imaging data, and planning the patient-specific cardiac procedure based on the simulating. The cardiac procedure is for providing a preselected alteration of at least one of electrophysiological or electromechanical behavior of the patient's heart.
FILED	Friday, February 10, 2012
APPL NO	13/984741
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/042 (20130101) Original (OR) Class A61B 5/055 (20130101) A61B 5/04021 (20130101) A61B 6/032 (20130101) A61B 6/037 (20130101) A61B 6/466 (20130101) A61B 6/503 (20130101) A61B 6/5223 (20130101) A61B 8/13 (20130101) A61B 8/0883 (20130101) A61B 34/10 (20160201) A61B 2505/05 (20130101) A61B 2576/023 (20130101) Image Data Processing or Generation, in General G06T 19/00 (20130101) G06T 2210/41 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101)
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10765399 — Programmable electronic stethoscope devices, algorithms, systems, and methods

US 10765399	Emmanouilidou et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Science Foundation (NSF)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Dimitra Emmanouilidou (Baltimore, Maryland); James E. West (Baltimore, Maryland); Mounya Elhilali (North Potomac, Maryland); Ian Mclane (Baltimore, Maryland)
ABSTRACT	A digital electronic stethoscope includes an acoustic sensor assembly that includes a body sensor portion and an ambient sensor portion, the body sensor portion being configured to make acoustically coupled contact with a subject while the ambient sensor portion is configured to face away from the body sensor portion so as to capture environmental noise proximate the body sensor portion; a signal processor and data storage system configured to communicate with the acoustic sensor assembly so as to receive detection signals therefrom, the detection signals including an auscultation signal comprising body target sound and a noise signal; and an output device configured to communicate with the signal processor and data storage system to provide at least one of an output signal or information derived from the output signal. The signal processor and data storage system includes a noise reduction system that removes both stationary noise and non-stationary noise from the detection signal to provide a clean auscultation signal substantially free of distortions. The signal processor and data storage system further includes an auscultation sound classification system configured to receive the clean auscultation signal and provide a classification thereof as at least one of a normal breath sound or an abnormal breath sound.
FILED	Monday, October 31, 2016
APPL NO	15/772454
ART UNIT	2655 — Digital Audio Data Processing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/7203 (20130101) A61B 5/7264 (20130101) A61B 7/003 (20130101) A61B 7/04 (20130101) Original (OR) Class A61B 7/026 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) G06N 99/00 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/178 (20130101) G10K 2210/116 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/51 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101)
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10765625 — Knottin-drug conjugates and methods of using the same

US 10765625	Cox et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Nicholas Cox (Seattle, Washington); Jennifer R. Cochran (Stanford, California); Mark Smith (San Francisco, California); James R. Kintzing (Stanford, California)
ABSTRACT	Provided are knottin-drug conjugates. The conjugates include a knottin peptide that includes an engineered loop that binds to a target on a cancer cell surface, and a drug (e.g., a nucleoside drug) conjugated to the knottin peptide through a linker. Also provided are pharmaceutical compositions and kits that include the knottin-drug conjugates, as well as methods of using the knottin-drug conjugates, e.g., for therapeutic purposes.
FILED	Tuesday, March 14, 2017
APPL NO	15/458852
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Original (OR) Class A61K 9/0053 (20130101) A61K 31/7068 (20130101) A61K 38/00 (20130101) A61K 47/00 (20130101) A61K 47/42 (20130101) A61K 47/64 (20170801) A61K 47/65 (20170801) Peptides C07K 14/4702 (20130101)
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10765634 — Controlled release formulations for the induction and proliferation of blood cells

US 10765634	Little et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
INVENTOR(S)	Steven R. Little (Allison Park, Pennsylvania); Giorgio Raimondi (Pittsburgh, Pennsylvania); Angus W. Thomson (Pittsburgh, Pennsylvania); Siddharth Jhunjhunwala (Chennai, India)
ABSTRACT	The absence of regulatory T cells (Treg) may underlie disorders including but not limited to autoimmunity, dermatitis, periodontitis and even transplant rejection. Enhancing local numbers of Treg through in situ Treg expansion or induction is contemplated herein as a treatment option for these disorders. Current methods for in vivo Treg expansion are not Treg specific and are associated with many adverse side-effects. The data presented herein provides in vitro testing of a Treg-inducing microparticle providing a predictable controlled release for combinations of cytokines and drugs (e.g., IL-2, TGF-β, and/or rapamycin) resulting in targeted Treg migration. These controlled release microparticles are also capable of inducing FoxP3+ Treg in human cells in vitro suggesting that these compositions be developed into an in vivo Treg induction and expansion therapy.
FILED	Tuesday, January 22, 2013
APPL NO	14/372977
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) Original (OR) Class A61K 9/1635 (20130101) A61K 9/1641 (20130101) A61K 9/1647 (20130101) A61K 9/1658 (20130101) A61K 31/203 (20130101) A61K 31/436 (20130101) A61K 38/1841 (20130101) A61K 38/2013 (20130101) A61K 38/2278 (20130101) A61K 39/001 (20130101) A61K 39/0008 (20130101)
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10765636 — Mesoporous silica nanoparticles with a lipid bilayer coating for cargo delivery

US 10765636	Nel et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Andre E. Nel (Sherman Oaks, California); Huan Meng (Los Angeles, California); Xiangsheng Liu (Los Angeles, California)
ABSTRACT	A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.
FILED	Thursday, October 18, 2018
APPL NO	16/164030
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 9/1278 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 9/5123 (20130101) A61K 9/5192 (20130101) A61K 31/4745 (20130101) A61K 45/06 (20130101) A61K 47/62 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) Y10S 977/907 (20130101)
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10765638 — Particle formulation with polycation complex

US 10765638	Saltzman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	YALE UNIVERSITY (New Haven, Connecticut)
INVENTOR(S)	W. Mark Saltzman (New Haven, Connecticut); Joseph Contessa (Guilford, Connecticut); Amanda King (New Haven, Connecticut)
ABSTRACT	Compositions and methods for efficient delivery of therapeutic agents in vivo are provided. Typically, the compositions are in the form of polymeric particles formed from one or more therapeutic agent complexed with a polycationic polymer which is further encapsulated in one or more amphiphilic polymers, preferably diblock copolymer of a polyalkylene oxide and a polyester such as poly(D,L-lactide)-poly(ethylene glycol) (PLA-PEG). In the preferred embodiments, the chemotherapeutic agent reduces, or inhibits N-glycosylation of one or more receptor tyrosine kinases of cancer cells. Methods of using the particles to treat cancer are also provided.
FILED	Friday, November 02, 2018
APPL NO	16/179605
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) Original (OR) Class A61K 9/5153 (20130101) A61K 31/506 (20130101) A61K 31/635 (20130101) A61K 45/06 (20130101) A61K 47/59 (20170801) A61K 47/6935 (20170801) A61K 47/6937 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101)
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10765645 — Sulfur(VI) fluoride compounds and methods for the preparation thereof

US 10765645	Dong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
ASSIGNEE(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S)	Jiajia Dong (Shanghai, China PRC); K. Barry Sharpless (La Jolla, California); Jeffery W. Kelly (La Jolla, California); Aleksandra Baranczak (Gurnee, Illinois); Wentao Chen (Walnut Creek, California)
ABSTRACT	This application describes a compound represented by Formula (I): YZX¹—S(O)(X²)F)_m]_n (I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X¹is a covalent bond or —CH₂CH₂—, X²is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.
FILED	Friday, October 12, 2018
APPL NO	16/158608
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) Original (OR) Class A61K 31/14 (20130101) A61K 31/40 (20130101) A61K 31/47 (20130101) A61K 31/53 (20130101) A61K 31/56 (20130101) A61K 31/65 (20130101) A61K 31/70 (20130101) A61K 31/136 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/397 (20130101) A61K 31/407 (20130101) A61K 31/439 (20130101) A61K 31/473 (20130101) A61K 31/485 (20130101) A61K 31/505 (20130101) A61K 31/515 (20130101) A61K 31/655 (20130101) A61K 31/4045 (20130101) A61K 31/4168 (20130101) A61K 31/4245 (20130101) A61K 31/4353 (20130101) A61K 31/4709 (20130101) A61K 31/4745 (20130101) A61K 31/5513 (20130101) A61K 31/7048 (20130101) A61K 38/31 (20130101) A61K 47/54 (20170801) A61K 51/0497 (20130101) Acyclic or Carbocyclic Compounds C07C 305/26 (20130101) C07C 2601/14 (20170501) C07C 2603/18 (20170501) Heterocyclic Compounds C07D 277/82 (20130101) C07D 279/08 (20130101) C07D 295/26 (20130101) C07D 295/088 (20130101) C07D 295/185 (20130101) Peptides C07K 1/02 (20130101) C07K 1/1136 (20130101) C07K 2/00 (20130101)
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10765652 — Reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions

US 10765652	Fazzari et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Marco Fazzari (Pittsburgh, Pennsylvania); Bruce A. Freeman (Pittsburgh, Pennsylvania); Francisco Jose Schopfer (Pittsburgh, Pennsylvania)
ABSTRACT	Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include reversible nitroxide derivatives of nitroalkenes. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
FILED	Wednesday, October 04, 2017
APPL NO	16/339703
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/201 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/04 (20180101) A61P 3/00 (20180101) A61P 3/04 (20180101) A61P 9/08 (20180101) A61P 13/12 (20180101) A61P 29/00 (20180101) Acyclic or Carbocyclic Compounds C07C 57/02 (20130101)
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10765654 — Methods and compounds for treating cancer

US 10765654	Jaworski
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR)
APPLICANT(S)	Diane M. Jaworski (Milton, Vermont)
ASSIGNEE(S)	University of Vermont and State Agricultural College (Burlington, Vermont)
INVENTOR(S)	Diane M. Jaworski (Milton, Vermont)
ABSTRACT	The invention includes, in part, methods and compounds for treating cancer including, but not limited to gliomas, melanomas, and neuroblastomas. In some embodiments of the invention, a glyceryltriacetate compound is administered to a subject in an amount effective to treat or prevent a cancer in the subject.
FILED	Thursday, July 19, 2012
APPL NO	14/233301
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/22 (20130101) A61K 31/22 (20130101) A61K 31/166 (20130101) A61K 31/166 (20130101) A61K 31/175 (20130101) A61K 31/175 (20130101) A61K 31/225 (20130101) Original (OR) Class A61K 31/475 (20130101) A61K 31/475 (20130101) A61K 31/4188 (20130101) A61K 31/4188 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10765673 — Methods and compositions useful for treating diseases involving Bcl-2 family proteins with quinoline derivatives

US 10765673	Cardone et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Eutropics Pharmaceuticals, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)	Eutropics Pharmaceuticals, Inc. (Cambridge, Massachusetts)
INVENTOR(S)	Michael H. Cardone (Dorchester, Massachusetts); David J. Richard (Littleton, Massachusetts)
ABSTRACT	The present invention relates to compositions and methods for cancer treatment comprising compounds of Formulae I, II, and III. In some aspects, the invention relates to the treatment of B-cell Lymphoma or other hematopoietic cancers. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as, for example, B-cell lymphoma, using a combination of one or more compounds of Formulae I, II, and III. Combination therapy with, for example, 26S proteasome inhibitors, such as, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formulae I, II, and III. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.
FILED	Monday, April 02, 2018
APPL NO	15/943112
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 31/69 (20130101) A61K 31/454 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/573 (20130101) A61K 31/573 (20130101) A61K 31/4709 (20130101) A61K 31/4709 (20130101) A61K 31/5377 (20130101) A61K 31/5377 (20130101) A61K 38/05 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/5079 (20130101) G01N 2333/82 (20130101) G01N 2500/04 (20130101) G01N 2500/10 (20130101)
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10765687 — Methods and compounds to inhibit enveloped virus release

US 10765687	Leis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Northwestern University (Evanston, Illinois); THE RESEARCH FOUNDATION FOR THE STATE OF UNIVERSITY OF NEW YORK (Albany, New York)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois); THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York)
INVENTOR(S)	Jonathan Leis (Chicago, Illinois); Carol Carter (Huntington, New York)
ABSTRACT	A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.
FILED	Friday, March 22, 2019
APPL NO	16/361556
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/65 (20130101) Original (OR) Class A61K 31/165 (20130101) A61K 31/415 (20130101) A61K 31/437 (20130101) A61K 31/4035 (20130101) A61K 31/4439 (20130101)
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10765694 — Compositions and methods for delivering inhibitory oligonucleotides

US 10765694	Arya et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, Maryland)
INVENTOR(S)	Bira Arya (Elliott City, Maryland); Purevdorj Olkhanud (Baltimore, Maryland); Juan Espinoza (Los Angeles, California)
ABSTRACT	The present invention features compositions and methods that make use of complexes comprising one or more inhibitory nucleic acids and a targeting polypeptide, wherein the targeting polypeptide consists of a cell surface receptor ligand. The compositions can be used in methods of silencing gene expression in a cell, delivering agents to a target cell, and in treating or preventing a disease or disorder in a subject.
FILED	Thursday, July 07, 2016
APPL NO	15/204789
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 47/642 (20170801) A61K 47/6455 (20170801) Peptides C07K 14/005 (20130101) C07K 14/523 (20130101) C07K 2319/33 (20130101) C07K 2319/74 (20130101) C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101)
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10765711 — Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human FLT3L or GM-CSF for cancer immunotherapy

US 10765711	Deng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S)	Memorial Sloan Kettering Cancer Center (New York, New York)
INVENTOR(S)	Liang Deng (New York, New York); Stewart Shuman (New York, New York); Jedd Wolchok (New York, New York); Taha Merghoub (New York, New York); Weiyi Wang (New York, New York); Peihong Dai (New York, New York); Ning Yang (New York, New York)
ABSTRACT	The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK⁻) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.
FILED	Monday, November 04, 2019
APPL NO	16/673475
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 35/768 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 48/00 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/521 (20130101) C07K 14/535 (20130101) C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/24121 (20130101) C12N 2710/24132 (20130101) C12N 2710/24133 (20130101) C12N 2710/24143 (20130101) C12N 2710/24161 (20130101)
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10765725 — Methods for treatment of surgery associated pain

US 10765725	Jankowski et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD)
APPLICANT(S)	Children's Hospital Medical Center (Cincinnati, Ohio)
ASSIGNEE(S)	Children's Hospital Medical Center (Cincinnati, Ohio)
INVENTOR(S)	Michael P. Jankowski (Union, Kentucky); Xiaohua Liu (Cincinnati, Ohio); John Barns Rose (Cincinnati, Ohio)
ABSTRACT	Disclosed are methods of treating pain in a mammal, which may include the step of administering human growth hormone to a mammal in need thereof. The pain treated by the disclosed methods may be of a type caused by inflammation induced mechanical and/or thermal hypersensitivity, and may include, for example, a pain type resulting from one or more conditions selected from peripheral injury pain, post-operative pain, cutaneous inflammation, cutaneous incision, muscle incision, or chronic pain. Disease states in which the disclosed methods may be used include fibromyalgia, sickle cell anemia, epidermolysis bullosa, erythromelalgia, complex regional pain syndrome, or generalized muscle pain.
FILED	Monday, November 05, 2018
APPL NO	16/180085
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/27 (20130101) Original (OR) Class
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10765731 — Fusion of heterooligomeric mycobacterial antigens

US 10765731	Marchand et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	TRANSGENE SA (Illkirch Graffenstaden, France)
ASSIGNEE(S)	TRANSGENE SA (Illkirch Graffenstaden, France)
INVENTOR(S)	Jean-Baptiste Marchand (Obernai, France); Nathalie Silvestre (Ergersheim, France); François Penin (Decines, France)
ABSTRACT	The present invention relates generally to novel immunogenic combinations comprising or encoding at least two heterooligomeric mycobacterial antigens and preferably a fusion polypeptide comprising said two heterooligomeric mycobacterial antigens, where the mycobacterial antigens are selected from the group of Esx, PE and PPE antigens of a Mycobacterium species, particularly a Mycobacterium of the tuberculosis complex such as Mycobacterium tuberculosis (Mtb). The present invention also relates to vectors, host cells and compositions comprising or encoding said immunogenic combination as well as to methods for expressing and producing it. The present invention also relates to methods of using said immunogenic combination, fusion polypeptide, vector, host cell, composition particularly for inducing or stimulating an immune response with the goal of providing a protective response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection.
FILED	Friday, January 09, 2015
APPL NO	15/110514
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/04 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/53 (20130101) A61K 2039/57 (20130101) A61K 2039/5256 (20130101) Peptides C07K 14/35 (20130101) C07K 16/1289 (20130101) C07K 2317/34 (20130101) C07K 2319/00 (20130101) C07K 2319/035 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/24141 (20130101)
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10765735 — Adjuvant compositions and methods of use

US 10765735	Vajdy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	EpitoGenesis, Inc. (Sacramento, California)
ASSIGNEE(S)	EpitoGenesis, Inc. (Sacramento, California)
INVENTOR(S)	Michael Vajdy (Sacramento, California); Shohre Golestani (Sacramento, California)
ABSTRACT	This disclosure provides adjuvant compositions that are capable of modulating the immune response in a subject. These adjuvant compositions may also be used enhance the immunogenicity of antigens. Also provided are methods of making the adjuvant compositions as well as methods of using the adjuvant compositions.
FILED	Wednesday, February 17, 2016
APPL NO	15/045986
ART UNIT	1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 39/145 (20130101) A61K 2039/541 (20130101) A61K 2039/543 (20130101) A61K 2039/55511 (20130101) A61K 2039/55588 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16034 (20130101) C12N 2740/16134 (20130101) C12N 2740/16334 (20130101) C12N 2760/16034 (20130101) C12N 2760/16134 (20130101) C12N 2760/16151 (20130101)
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10765736 — Vaccine composition containing synthetic adjuvant

US 10765736	Reed et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Infectious Disease Research Institute (Seattle, Washington)
ASSIGNEE(S)	Infectious Disease Research Institute (Seattle, Washington)
INVENTOR(S)	Steven G. Reed (Bellevue, Washington); Darrick Carter (Seattle, Washington)
ABSTRACT	Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.
FILED	Tuesday, November 28, 2017
APPL NO	15/823852
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) A61K 39/04 (20130101) A61K 39/008 (20130101) A61K 39/0011 (20130101) A61K 39/35 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 39/145 (20130101) A61K 45/06 (20130101) A61K 2039/55511 (20130101) A61K 2039/55572 (20130101) Technologies for Adaptation to Climate Change Y02A 50/39 (20180101) Y02A 50/41 (20180101) Y02A 50/386 (20180101) Y02A 50/388 (20180101) Y02A 50/396 (20180101) Y02A 50/491 (20180101)
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10765739 — Use of MIF and MIF pathway agonists

US 10765739	Bucala et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	Yale University (New Haven, Connecticut)
INVENTOR(S)	Richard Bucala (Greenwich, Connecticut); Lawrence H. Young (Woodbridge, Connecticut)
ABSTRACT	The present invention relates to novel methods and compositions for increasing AMPK activity and glucose uptake comprising administering a macrophage migration inhibitory factor (MIF) pathway agonist in a subject in need thereof. The invention also relates to methods for selecting a subject for treatment with an agonist of MIF, identifying a subject at risk for developing a condition in which increased AMPK activity is desirable, and for predicting whether a subject is susceptible to a condition in which increased AMPK activity is desirable.
FILED	Thursday, July 13, 2017
APPL NO	15/648956
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 39/3955 (20130101) Original (OR) Class Peptides C07K 14/52 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/166 (20130101)
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10765754 — Compositions and methods related to inhibition of respiratory syncytial virus entry

US 10765754	Welch et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Navigen, Inc. (Salt Lake City, Utah); University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	Navigen, Inc. (Salt Lake City, Utah); University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Brett D. Welch (Salt Lake City, Utah); Michael S. Kay (Salt Lake City, Utah); Debra Muir Eckert (Salt Lake City, Utah); Rena McKinnon (Herriman, Utah); Michael Thomas Jacobsen (Norfolk, Nebraska)
ABSTRACT	Disclosed herein are compositions and methods for inhibiting respiratory syncytial virus (RSV) entry into a host cell. Also provided herein are methods of identifying a peptide that interacts with the N-trimer of RSV F protein.
FILED	Friday, August 26, 2016
APPL NO	15/753950
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/02 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/16 (20130101) A61K 38/162 (20130101) A61K 47/42 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101)
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10765757 — Mucosal delivery of therapeutic molecules, proteins, or particles coupled to ceramide lipids

US 10765757	Lencer et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Wayne I. Lencer (Jamaica Plain, Massachusetts); Daniel J F Chinnapen (Quincy, Massachusetts); Randy Mrsny (Bath, United Kingdom)
ABSTRACT	Described herein are compositions and methods useful for allowing for the absorption (passage) of agents of interest, such as therapeutic agents, across epithelial and mucosal barriers and/or into certain subcellular compartments of the cell, such as the recycling endosome (RE), Golgi, and the endoplasmic reticulum (ER).
FILED	Friday, September 02, 2016
APPL NO	15/255595
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4164 (20130101) A61K 38/26 (20130101) A61K 39/15 (20130101) A61K 47/61 (20170801) A61K 47/543 (20170801) A61K 47/544 (20170801) A61K 47/549 (20170801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2720/12322 (20130101) C12N 2720/12334 (20130101)
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10765763 — Radioligands for myelin

US 10765763	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S)	Yanming Wang (Beachwood, Ohio); Chunying Wu (Beachwood, Ohio)
ABSTRACT	A radioligand for labeling myelin includes a fluorescent trans-stilbene derivative.
FILED	Thursday, March 09, 2017
APPL NO	16/083747
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 51/04 (20130101) Original (OR) Class A61K 51/0453 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 2800/52 (20130101) G01N 2800/285 (20130101)
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10765875 — Implantable cardiac devices and methods for delivering low energy, pain-free defibrillation signals for ventricular arrhythmias

US 10765875	Dosdall et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
INVENTOR(S)	Derek J. Dosdall (Centerville, Utah); Ravi Ranjan (Salt Lake City, Utah)
ABSTRACT	An implantable cardioverter defibrillator (ICD) and methods of detection and treatment of dangerous and life-threatening heart rhythms by delivering real-time, customized low-energy pacing pulses to specific anatomy in the heart. The ICD includes a power source, a controller, powered by the power source, including an electronic processor, a memory, and a signal generator. The ICD also includes a lead coupled to the controller and an electrode that is in electrical communication with a His-bundle of a patient's heart. The ICD detects a ventricular arrhythmia of the patient's heart using the controller, and is configured to provide a pulsed defibrillation signal to the electrode to terminate the ventricular arrhythmia.
FILED	Friday, May 04, 2018
APPL NO	15/971883
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3702 (20130101) A61N 1/3937 (20130101) A61N 1/3987 (20130101) A61N 1/39622 (20170801) Original (OR) Class
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10765878 — Compositions and methods to modulate cell activity

US 10765878	Stanley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	THE ROCKEFELLER UNIVERSITY (New York, New York); RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
ASSIGNEE(S)	THE ROCKEFELLER UNIVERSITY (New York, New York); RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
INVENTOR(S)	Sarah Stanley (New York, New York); Jeffrey Friedman (New York, New York); Jonathan S. Dordick (Schenectady, New York); Jeremy Sauer (Princeton, New Jersey)
ABSTRACT	The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.
FILED	Tuesday, March 21, 2017
APPL NO	15/464748
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 47/6929 (20170801) A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0075 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/00 (20130101) A61N 2/002 (20130101) Original (OR) Class A61N 2/004 (20130101) A61N 2/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101) Peptides C07K 14/705 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/10343 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/042 (20130101)
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10766014 — Systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer

US 10766014	Koswara et al.
FUNDED BY	Department of Health and Human Services (HHS) Food and Drug Administration (FDA)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Andy Koswara (West Lafayette, Indiana); Zoltan Kalman Nagy (West Lafayette, Indiana)
ABSTRACT	The invention generally relates to systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer. In certain aspects, the invention provides a system that includes a plug flow crystallizer having a channel, one or more heating/cooling elements, each operably associated with a different segment of the channel, and a controller. The controller is operably coupled to the one or more heating/cooling elements and configured to implement a temperature profile within the channel of the plug flow crystallizer that grows crystals in a plug of fluid that flows through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plug of fluid in the second segment of the channel. In certain embodiments, these segments may be cyclically alternated, in that the segment in which crystal grows in one cycle becomes the segment in which crystal dissolves in the next cycle and vice versa, to realize a fully continuous crystallization process.
FILED	Tuesday, April 25, 2017
APPL NO	15/496355
ART UNIT	1714 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Separation B01D 9/0013 (20130101) B01D 9/0036 (20130101) B01D 9/0054 (20130101) B01D 9/0059 (20130101) B01D 9/0063 (20130101) B01D 9/0072 (20130101) B01D 9/0077 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0013 (20130101) Original (OR) Class Cleaning in General; Prevention of Fouling in General B08B 7/0064 (20130101) B08B 17/00 (20130101) Acyclic or Carbocyclic Compounds C07C 227/42 (20130101) C07C 231/24 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/08 (20130101) C30B 29/54 (20130101)
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10766762 — Controlled fabrication of nanopores in nanometric solid state materials

US 10766762	Russo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Christopher John Russo (Cambridge, United Kingdom); Jene A. Golovchenko (Lexington, Massachusetts); Daniel Branton (Lexington, Massachusetts)
ABSTRACT	There is provided a nanometric structure that includes a self-supporting nanometric material having a thickness of no more than about 5 nm. A plurality of nanopores is provided in the nanometric material, and the nanopore plurality has a density of at least about 1000 nanopores/cm². Each nanopore in the plurality of nanopores has a diameter that is no greater than about 10 nm. The plurality of nanopores is monodisperse in diameter with a variation of about ±30%. In a further nanometric structure provided herein there is included a self-supporting nanometric material having a thickness of no more than about 5 nm. A plurality of nanopores in the nanometric material includes at least about 50 nanopores. Each nanopore in the plurality of nanopores has a diameter that is no greater than about 10 nm. The plurality of nanopores is monodisperse in diameter with a variation of about ±30%.
FILED	Friday, February 17, 2017
APPL NO	15/435595
ART UNIT	1788 — Miscellaneous Articles, Stock Material
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/266 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 1/002 (20130101) Original (OR) Class B81B 2201/0214 (20130101) B81B 2203/0127 (20130101) B81B 2207/056 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00087 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48721 (20130101)
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10766877 — Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof

US 10766877	Han et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Crinetics Pharmaceuticals, Inc. (San Diego, California)
ASSIGNEE(S)	CRINETICS PHARMACEUTICALS, INC. (San Diego, California)
INVENTOR(S)	Sangdon Han (San Diego, California); Yunfei Zhu (San Diego, California); Sun Hee Kim (San Diego, California); Jian Zhao (San Diego, California)
ABSTRACT	Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity.
FILED	Friday, December 13, 2019
APPL NO	16/713601
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 295/04 (20130101) C07D 401/10 (20130101) C07D 401/14 (20130101) Original (OR) Class C07D 407/14 (20130101)
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10766886 — Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof

US 10766886	Cuervo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute on Aging (NIA) National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S)	ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York)
ASSIGNEE(S)	ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York)
INVENTOR(S)	Ana Maria Cuervo (Bronx, New York); Evripidis Gavathiotis (Flushing, New York); Qisheng Xin (Bronx, New York); Bhaskar C. Das (Kansas City, Kansas)
ABSTRACT	Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RARα) in subjects in need thereof.
FILED	Wednesday, December 05, 2018
APPL NO	16/210895
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/11 (20130101) Acyclic or Carbocyclic Compounds C07C 279/22 (20130101) C07C 2601/16 (20170501) Heterocyclic Compounds C07D 265/36 (20130101) C07D 413/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2500/04 (20130101) G01N 2800/7009 (20130101)
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10766923 — Methods and compositions to increase the rate of ligation reactions catalyzed by a sortase

US 10766923	Clubb et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Robert T. Clubb (Culver City, California); Brendan R. Amer (Los Angeles, California)
ABSTRACT	In various embodiments methods and compositions to increase the rate and/or activity of ligation reactions catalyzed by a sortase. In certain embodiments reagents are provided that comprises, inter alia, a polypeptide comprising an amino terminal polyglycine sequence comprising at least three contiguous Gly residues (e.g., a triglycine sequence, a tetraglycine sequence, a pentaglycine sequence, etc.) followed by a peptide that is to be ligated to a moiety followed by a sequence comprising the catalytic domain of a Sortase A enzyme.
FILED	Thursday, January 26, 2017
APPL NO	16/072155
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 1/13 (20130101) Original (OR) Class C07K 7/06 (20130101) C07K 14/35 (20130101) C07K 14/47 (20130101) C07K 2319/00 (20130101) C07K 2319/21 (20130101) C07K 2319/35 (20130101) C07K 2319/50 (20130101) C07K 2319/90 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) C12N 15/52 (20130101) C12N 15/63 (20130101) C12N 15/113 (20130101) C12N 2310/3181 (20130101) C12N 2310/3517 (20130101) Enzymes C12Y 304/2207 (20130101)
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10766925 — Opioid receptor modulators

US 10766925	Vardanyan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona)
INVENTOR(S)	Ruben Vardanyan (Tucson, Arizona); Victor Hruby (Tucson, Arizona)
ABSTRACT	The present invention provides compounds that can modulate opioid receptors. Some compounds of the invention are modulators of μ- and/or δ-opioid receptors. Still other compounds of the invention are opioid receptor antagonists. Some compounds of the invention can modulate opioid receptors with a significantly less likelihood of developing addiction or abuse compared to conventional opioid ligands, such as morphine. In particular, compounds of the invention are of the formula: wherein Ar¹is H, optionally substituted aryl or optionally substituted heteroaryl; R¹is a heteroalkyl; R²is alkyl; R³is an oligopeptide or a moiety of the formula —R⁴—Y; R⁴is alkylene; Y is optionally substituted heteroaryl, optionally substituted aryl or a moiety of the formula —C(═X²)—X³—R⁵; each of X¹, X²and X³is independently O, NR⁶or S; and each of R⁵and R⁶is independently H or alkyl.
FILED	Tuesday, April 11, 2017
APPL NO	16/090102
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Heterocyclic Compounds C07D 211/58 (20130101) Peptides C07K 4/00 (20130101) Original (OR) Class
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10766928 — Targeted conformationally-constrained kinked endosomal disrupting peptides

US 10766928	Peterson
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The University of Kansas (Lawrence, Kansas)
ASSIGNEE(S)	The University of Kansas (Lawrence, Kansas)
INVENTOR(S)	Blake R. Peterson (Lawrence, Kansas)
ABSTRACT	A peptide can have a sequence of one of SEQ ID NOs: 78-91. A conformationally-constrained kinked peptide includes: a conformationally-constraining portion and a kinked portion linked to the conformationally-constraining portion that conformationally constrains the kinked portion having a peptide sequence of one of SEQ NOs: 78-97. A cell-targeting compound can include a conformationally-constrained kinked peptide having a peptide sequence of one of SEQ ID NOs: 78-97. The peptide sequence can be one of SEQ ID NOs: 78-97, or 78-91, or 92-97. A cell-targeting compound can include a conformationally-constrained kinked peptide linked to a branched linker with one branch arm linked to a specific targeting moiety and one branch arm linked to a general targeting moiety. The specific targeting moiety can be an antibody. The general targeting moiety can be a lipid or cholesterol derivative.
FILED	Wednesday, April 05, 2017
APPL NO	15/480120
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/65 (20170801) A61K 47/554 (20170801) A61K 47/6811 (20170801) A61K 47/6849 (20170801) A61K 47/6851 (20170801) A61K 47/6889 (20170801) Peptides C07K 7/08 (20130101) Original (OR) Class C07K 16/32 (20130101) C07K 16/2887 (20130101) C07K 2317/24 (20130101) C07K 2317/73 (20130101) C07K 2319/06 (20130101) C07K 2319/74 (20130101)
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10766929 — De novo designed hemagglutinin binding proteins

US 10766929	Baker et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	UNIVERSITY OF WASHINGTON (Seattle, Washington)
ASSIGNEE(S)	University of Washington (Seattle, Washington)
INVENTOR(S)	David Baker (Seattle, Washington); Aaron Arthur Chevalier (Seattle, Washington); Gabriel Jacob Rocklin (Seattle, Washington); Christopher David Bahl (Seattle, Washington); Lance Joseph Stewart (Seattle, Washington); Daniel Adriano Silva Manzano (Seattle, Washington); Deborah L. Fuller (Seattle, Washington); Merika Treants Koday (Seattle, Washington); Jason Gilmore (Seattle, Washington)
ABSTRACT	Polypeptides that bind to viral hemagglotinin are disclosed and methods for their use in treating or limiting influenza infection, and diagnosing influenza infection.
FILED	Thursday, March 15, 2018
APPL NO	16/483865
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 14/001 (20130101) Original (OR) Class C07K 16/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/11 (20130101) G01N 2500/04 (20130101) G01N 2800/26 (20130101)
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10766932 — Multiple antigen presenting immunogenic composition, and methods and uses thereof

US 10766932	Malley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Richard Malley (Beverly, Massachusetts); Yingjie Lu (West Roxbury, Massachusetts); Fan Zhang (West Roxbury, Massachusetts)
ASSIGNEE(S)	THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
INVENTOR(S)	Richard Malley (Beverly, Massachusetts); Yingjie Lu (West Roxbury, Massachusetts); Fan Zhang (West Roxbury, Massachusetts)
ABSTRACT	The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.
FILED	Friday, May 11, 2012
APPL NO	14/116402
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/092 (20130101) A61K 39/385 (20130101) A61K 47/61 (20170801) A61K 47/543 (20170801) A61K 47/557 (20170801) A61K 2039/70 (20130101) A61K 2039/625 (20130101) A61K 2039/627 (20130101) A61K 2039/645 (20130101) A61K 2039/6031 (20130101) A61K 2039/6093 (20130101) A61K 2039/55505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/31 (20130101) Original (OR) Class C07K 2319/00 (20130101) C07K 2319/20 (20130101) Technologies for Adaptation to Climate Change Y02A 50/484 (20180101)
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10766936 — Treatment of ischemia

US 10766936	Simon et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	MOREHOUSE SCHOOL OF MEDICINE (Atlanta, Georgia)
ASSIGNEE(S)	MOREHOUSE SCHOOL OF MEDICINE (Atlanta, Georgia)
INVENTOR(S)	Roger P. Simon (Atlanta, Georgia); Zhigang Xiong (Atlanta, Georgia)
ABSTRACT	A system, including methods and compositions, for treatment of ischemia.
FILED	Tuesday, April 23, 2019
APPL NO	16/391774
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/439 (20130101) A61K 31/498 (20130101) A61K 31/4418 (20130101) A61K 31/4965 (20130101) A61K 38/16 (20130101) A61K 38/17 (20130101) A61K 38/1767 (20130101) A61K 45/06 (20130101) Peptides C07K 14/43518 (20130101) Original (OR) Class
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10766937 — Compositions and methods of treating cancer

US 10766937	Nakatani
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Yoshihiro Nakatani (Chestnut Hill, Massachusetts)
ASSIGNEE(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S)	Yoshihiro Nakatani (Chestnut Hill, Massachusetts)
ABSTRACT	The present invention provides compositions and methods of treating various disorders associated with aberrant cell growth.
FILED	Thursday, September 06, 2012
APPL NO	14/343022
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4702 (20130101) C07K 14/4747 (20130101) Original (OR) Class
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10766947 — Polymeric forms of H-NOX proteins

US 10766947	Kapp et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Omniox, Inc. (San Carlos, California)
ASSIGNEE(S)	Omniox, Inc. (San Carlos, California)
INVENTOR(S)	Gregory Kapp (San Francisco, California); Laura Serwer (Brisbane, California); Natacha Le Moan (San Francisco, California); Stephen P. L. Cary (San Mateo, California)
ABSTRACT	The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
FILED	Monday, June 24, 2019
APPL NO	16/450913
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/41 (20130101) A61K 38/164 (20130101) A61K 45/06 (20130101) Peptides C07K 14/795 (20130101) Original (OR) Class C07K 2319/21 (20130101)
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10766950 — Methods, compositions and kits for treating a subject using a recombinant neutralizing binding protein

US 10766950	Shoemaker
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	TUFTS UNIVERSITY (Boston, Massachusetts)
ASSIGNEE(S)	TUFTS UNIVERSITY (Boston, Massachusetts)
INVENTOR(S)	Charles B. Shoemaker (Boston, Massachusetts)
ABSTRACT	Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes a disease agent that is a toxin, for example a Clostridium difficile toxin, a Shiga toxin, a ricin toxin, or an anthrax toxin.
FILED	Wednesday, January 02, 2019
APPL NO	16/237877
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/16 (20130101) C07K 16/18 (20130101) C07K 16/1228 (20130101) C07K 16/1278 (20130101) C07K 16/1282 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/31 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2319/40 (20130101)
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10766968 — Methods and compositions relating to anti-CHI3L1 antibody reagents to treat cancer

US 10766968	Elias et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	BROWN UNIVERSITY (Providence, Rhode Island)
ASSIGNEE(S)	BROWN UNIVERSITY (Providence, Rhode Island)
INVENTOR(S)	Jack A. Elias (Providence, Rhode Island); Chun Geun Lee (Woodbridge, Connecticut); Chuan Hua He (Madison, Connecticut); Bing Ma (Branford, Connecticut); Suchitra Kamle (Providence, Rhode Island); Chang-Min Lee (Warwick, Rhode Island)
ABSTRACT	It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for cancer, e.g., comprising an inhibitor of CHI3L1; and an inhibitor of an immune checkpoint protein. In some embodiments, the CHI3L1 inhibitor can be an antibody or antibody reagent as described herein.
FILED	Friday, September 07, 2018
APPL NO	16/124575
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 16/2803 (20130101) C07K 16/2839 (20130101) C07K 2317/34 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101)
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10767112 — Methods of producing metal sulfides, metal selenides, and metal sulfides/selenides having controlled architectures using kinetic control

US 10767112	Owen et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); Gregory T. Cleveland (Missouri City, Texas); Ilan Jen-La Plante (New York, New York); Leslie Sachiyo Hamachi (New York, New York)
ASSIGNEE(S)	The Trustees of the Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Jonathan S. Owen (New York, New York); Mark P. Hendricks (Richland, Washington); Michael P. Campos (New York, New York); Gregory T. Cleveland (Missouri City, Texas); Ilan Jen-La Plante (New York, New York); Leslie Sachiyo Hamachi (New York, New York)
ABSTRACT	The present invention is directed to methods of preparing metal sulfide, metal selenide, or metal sulfide/selenide nanoparticles and the products derived therefrom. In various embodiments, the nanoparticles are derived from the reaction between precursor metal salts and certain sulfur- and/or selenium-containing precursors each independently having a structure of Formula (I), (II), or (III), or an isomer, salt, or tautomer thereof, where Q¹, Q², Q³, R¹, R², R³, R⁵, and X are defined within the specification.
FILED	Friday, January 15, 2016
APPL NO	15/541937
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/04 (20130101) C01B 19/007 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 1/12 (20130101) C01G 3/12 (20130101) C01G 9/08 (20130101) C01G 11/02 (20130101) C01G 19/00 (20130101) C01G 19/006 (20130101) C01G 21/21 (20130101) C01G 53/11 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/84 (20130101) C01P 2004/04 (20130101) C01P 2004/16 (20130101) C01P 2004/24 (20130101) C01P 2004/32 (20130101) C01P 2004/64 (20130101) C01P 2004/80 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/565 (20130101) C09K 11/582 (20130101) C09K 11/602 (20130101) C09K 11/661 (20130101) C09K 11/881 (20130101) C09K 11/883 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/04 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/95 (20130101) Y10S 977/774 (20130101) Y10S 977/824 (20130101) Y10S 977/825 (20130101) Y10S 977/892 (20130101) Y10S 977/896 (20130101)
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10767162 — Methods for differentiation

US 10767162	Li et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S)	Victor Chun Li (Boston, Massachusetts); Marc W. Kirschner (Newton, Massachusetts)
ABSTRACT	Described herein are methods relating to the differentiation of stem cells to more differentiated phenotypes, e.g. to terminally differentiated cell types and/or precursors thereof. In some embodiments, the methods relate to contacting the stem cells with differentiation factors and halting the cell cycle, thereby increasing the rate of differentiation.
FILED	Monday, December 17, 2018
APPL NO	16/222184
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0619 (20130101) Original (OR) Class C12N 2501/60 (20130101) C12N 2501/405 (20130101) C12N 2501/606 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101)
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10767168 — Engineered CRISPR-Cas9 nucleases with altered PAM specificity

US 10767168	Joung et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	J. Keith Joung (Winchester, Massachusetts); Benjamin Kleinstiver (Medford, Massachusetts)
ABSTRACT	Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
FILED	Monday, July 31, 2017
APPL NO	15/664873
ART UNIT	1699 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2227/40 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 2319/71 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/63 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2800/22 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 301/00 (20130101)
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10767178 — Compositions and methods of using piRNAS in cancer diagnostics and therapeutics

US 10767178	Zhu
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	YALE UNIVERSITY (New Haven, Connecticut)
INVENTOR(S)	Yong Zhu (Cheshire, Connecticut)
ABSTRACT	Aberrantly expressed piRNAs, genetically associated piRNAs and their relationship with cancer risk and severity are provided. Compositions and methods of using piRNA for treating cancer are provided. Methods of diagnosing subjects and determining the efficacy of active agents for treating cancer are also provided. Methods of correlating variant piRNA to cancer are also disclosed.
FILED	Monday, February 27, 2017
APPL NO	16/079868
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/10 (20130101) C12N 2310/141 (20130101) C12N 2320/10 (20130101) C12N 2320/11 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101)
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10767184 — Chimeric antigen receptors targeting B-cell maturation antigen

US 10767184	Kochenderfer
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	James N. Kochenderfer (Bethesda, Maryland)
ABSTRACT	The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
FILED	Thursday, August 31, 2017
APPL NO	15/692473
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2878 (20130101) C07K 2317/73 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class
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10767194 — RNA-guided transcriptional regulation

US 10767194	Church et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Office of Science Consolidated Service Center (CSC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	George M. Church (Brookline, Massachusetts); Prashant G. Mali (La Jolla, California); Kevin M. Esvelt (Auburndale, Massachusetts)
ABSTRACT	Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.
FILED	Friday, June 14, 2019
APPL NO	16/441209
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/3513 (20130101) Enzymes C12Y 301/00 (20130101)
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10767212 — Method of screening compounds

US 10767212	Cerione et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Cornell University (Ithaca, New York)
ASSIGNEE(S)	Cornell University (Ithaca, New York)
INVENTOR(S)	Richard Cerione (Ithaca, New York); Jon W Erickson (Freeville, New York); Clint A Stalnecker (Chapel Hill, North Carolina)
ABSTRACT	The present technology relates to kidney-type glutaminase (GLS) proteins that have a phenylalanine to tryptophan substitution at the position corresponding to residue 322 of human glutaminase C (GAC), and methods of using such proteins to screen for compounds that bind to the activation loop of GLS and/or modulate glutaminase activity of GLS.
FILED	Monday, September 25, 2017
APPL NO	15/714885
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Original (OR) Class Enzymes C12Y 305/01002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2500/04 (20130101) G01N 2500/20 (20130101)
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10767216 — Methods for distinguishing 5-hydroxymethylcytosine from 5-methylcytosine

US 10767216	Rao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Anjana Rao (La Jolla, California); Mamta Tahiliani (New York, New York); Kian Peng Koh (Jamaica Plain, Massachusetts); Suneet Agarwal (Belmont, Massachusetts); Aravind Iyer (Bethesda, Maryland)
ABSTRACT	Provided herein are methods and kits for distinguishing 5-hydroxymethylcytosine from 5-methylcytosine.
FILED	Monday, November 05, 2018
APPL NO	16/180450
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2501/70 (20130101) C12N 2501/71 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/26 (20130101) C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) Original (OR) Class C12Q 1/6827 (20130101) C12Q 1/6869 (20130101) C12Q 2521/531 (20130101) C12Q 2521/531 (20130101) C12Q 2522/10 (20130101) C12Q 2522/10 (20130101) C12Q 2537/164 (20130101) C12Q 2537/164 (20130101) C12Q 2600/154 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101)
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10767227 — Compositions and methods for determining genetic polymorphisms in the TMEM216 gene

US 10767227	Gleeson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Joseph G. Gleeson (San Diego, California); Jennifer Silhavy (San Diego, California); Enza Maria Valente (Rome, Italy); Francesco Brancati (Rome, Italy)
ABSTRACT	In alternative embodiments, the invention provides nucleic acid sequences that are genetic polymorphic variations of the human TMEM216 gene, and TMEM216 polypeptide encoded by these variant alleles. In alternative embodiments, the invention provides methods of determining or predicting a predisposition to, or the presence of, a ciliopathy (or any genetic disorder of a cellular cilia or cilia anchoring structure, basal body or ciliary function) in an individual, such as a Joubert Syndrome (JS), a Joubert Syndrome Related Disorder (JSRD) or a Meckel Syndrome (MKS). In alternative embodiments, the invention provides compositions and methods for the identification of genetic polymorphic variations in the human TMEM216 gene, and methods of using the identified genetic polymorphisms and the proteins they encode, e.g., to screen for compounds that can modulate the human TMEM216 gene product, and possibly treat JS, JSRD or MKS. In alternative embodiments, the invention provides cells, cell lines and/or non-human transgenic animals that can be used as screening or model systems for studying ciliopathies and testing various therapeutic approaches in treating ciliopathies, e.g., JS, JSRD or MKS.
FILED	Tuesday, December 12, 2017
APPL NO	15/839096
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2207/05 (20130101) A01K 2217/054 (20130101) A01K 2227/40 (20130101) Peptides C07K 14/47 (20130101) C07K 16/28 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 33/6896 (20130101) G01N 2500/04 (20130101) G01N 2800/28 (20130101) G01N 2800/50 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/105831 (20150115)
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10768080 — Method of purifying tumor cells using shear stress

US 10768080	Henry et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
ASSIGNEE(S)	University of Iowa Research Foundation (Iowa City, Iowa)
INVENTOR(S)	Michael D. Henry (Iowa City, Iowa); J. Matthew Barnes (Iowa City, Iowa)
ABSTRACT	Methods for isolating viable cancer cells from a sample that comprises a mixture of cancerous cells and normal (non-cancerous) cells are provided. In the methods, a fluid preparation comprising a mixture of cancerous and normal cells is repeatedly exposed to fluid shear stresses, whereby the repeated exposure to the fluid shear stresses preferentially imparts fluid shear stress-resistance to the cancerous cells.
FILED	Monday, April 02, 2018
APPL NO	15/943187
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 2200/027 (20130101) B01L 2200/0647 (20130101) B01L 2400/0475 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 2521/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) Original (OR) Class G01N 33/487 (20130101) G01N 33/574 (20130101) G01N 33/5026 (20130101) G01N 33/5044 (20130101) G01N 33/5091 (20130101)
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10768168 — Methods for identifying arthropod repellents and attractants, and compounds and compositions identified by such methods

US 10768168	Ray et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Anandasankar Ray (Riverside, California); Sean Michael Boyle (Lakewood Ranch, Florida); Dyan MacWilliam (Riverside, California); Genevieve Mitchell Tauxe (Riverside, California)
ABSTRACT	Provided herein are screening methods for identifying compounds for use as an arthropod repellent based on the masking or inhibition of the detection of the skin odor by a cpA neuron. Provided herein are also screening methods for identifying compounds for use as an arthropod attractant based on activation of the cpA neuron. Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds.
FILED	Thursday, December 21, 2017
APPL NO	15/851130
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 31/02 (20130101) A01N 31/02 (20130101) A01N 31/06 (20130101) A01N 31/06 (20130101) A01N 33/04 (20130101) A01N 35/02 (20130101) A01N 35/02 (20130101) A01N 35/02 (20130101) A01N 35/02 (20130101) A01N 35/02 (20130101) A01N 35/04 (20130101) A01N 35/04 (20130101) A01N 35/06 (20130101) A01N 35/06 (20130101) A01N 35/06 (20130101) A01N 35/08 (20130101) A01N 37/02 (20130101) A01N 37/02 (20130101) A01N 37/02 (20130101) A01N 37/02 (20130101) A01N 37/42 (20130101) A01N 37/42 (20130101) A01N 37/42 (20130101) A01N 41/10 (20130101) A01N 43/08 (20130101) A01N 43/08 (20130101) A01N 43/10 (20130101) A01N 43/10 (20130101) A01N 43/10 (20130101) A01N 43/36 (20130101) A01N 43/36 (20130101) A01N 43/36 (20130101) A01N 43/78 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5032 (20130101) G01N 33/5058 (20130101) Original (OR) Class
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10768170 — Predictive biomarkers for CTLA-4 blockade therapy and for PD-1 blockade therapy

US 10768170	Weber et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida)
ASSIGNEE(S)	H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida)
INVENTOR(S)	Jeffrey S. Weber (Tampa, Florida); Wenshi Wang (Tampa, Florida); Bin Yu (Tampa, Florida)
ABSTRACT	Biomarkers are described for predicting the efficacy, risk of relapse, risk of an immune related adverse event (irAE), or combination thereof for a CTLA-4 blockade treatment, such as ipilimumab, in a subject with melanoma. Biomarkers are also described for predicting the efficacy and clinical benefit for a PD-1 blockade treatment, such as a PD-1 blocking antibody, in a subject with melanoma.
FILED	Monday, January 08, 2018
APPL NO	15/864276
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/2818 (20130101) C07K 16/3053 (20130101) C07K 2317/21 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) Original (OR) Class G01N 33/5743 (20130101) G01N 33/56972 (20130101) G01N 2333/70517 (20130101) G01N 2800/52 (20130101)
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10768180 — Polyelectrolyte-coated polymer dots and related methods

US 10768180	Chiu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Washington through its Center for Commercialization (Seattle, Washington)
ASSIGNEE(S)	UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington)
INVENTOR(S)	Daniel T. Chiu (Seattle, Washington); Yuhui Jin (Painted Post, New York); Fangmao Ye (Seattle, Washington); Changfeng Wu (Changchun, China PRC); Yang-Hsiang Chan (Seattle, Washington)
ABSTRACT	Polymer nanoparticles and related methods are provided. The polymer particles can include polymer dots having a coating including a polyelectrolyte polymer. Methods of making and using the polymer nanoparticles are also provided.
FILED	Friday, July 20, 2018
APPL NO	16/041569
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0065 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 15/00 (20130101) B82Y 40/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/588 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0036 (20130101) H01L 51/0039 (20130101) H01L 51/0043 (20130101) H01L 51/5012 (20130101)
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10768185 — Tenofovir detection assay

US 10768185	Klapperich et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
ASSIGNEE(S)	TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
INVENTOR(S)	Catherine M. Klapperich (Brookline, Massachusetts); George Woodman Pratt, IV (Everett, Massachusetts); Andy Fan (Cambridge, Massachusetts)
ABSTRACT	Disclosed herein are antibodies capable of specifically binding to tenofovir (TFV), a key small molecule drug for both the treatment and prevention of HIV, and a competitive lateral flow assay that uses these antibodies to monitor urine samples for the presence of the drug. The assay can be deployed as a point-of-care device for adherence monitoring.
FILED	Friday, July 20, 2018
APPL NO	16/040994
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) Original (OR) Class G01N 33/558 (20130101)
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10768260 — System and method for controlling noise in magnetic resonance imaging using a local low rank technique

US 10768260	Moeller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Steen Moeller (Golden Valley, Minnesota); Mehmet Akcakaya (Minneapolis, Minnesota)
ABSTRACT	A system and method for controlling noise in magnetic resonance imaging (MRI) are provided. In one aspect, the method includes reconstructing a series of images of the target using the image data, with each image being defined using signal-to-noise (SNR) units, and selecting an image patch corresponding to the series of images. The method also includes forming a matrix by combining vectors generated using the image patch, and applying a local low rank denoising technique using the matrix and the series of images to generate at least one denoised image.
FILED	Monday, September 17, 2018
APPL NO	16/133550
ART UNIT	2868 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/565 (20130101) Original (OR) Class G01R 33/5611 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/50 (20130101) G06T 7/0012 (20130101) G06T 11/005 (20130101) G06T 2207/10016 (20130101) G06T 2207/10088 (20130101) G06T 2207/20182 (20130101) G06T 2207/30024 (20130101)
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10768261 — Alternating gradients for metal-induced artifacts correction in magnetic resonance imaging

US 10768261	Shi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Xinwei Shi (Stanford, California); Brian A. Hargreaves (Menlo Park, California)
ABSTRACT	A method for magnetic resonance imaging suppresses off-resonance gradient-induced image artifacts due to metal. The method includes performing by a magnetic resonance imaging (MRI) apparatus two multi-spectral imaging (MSI) acquisitions within a field of view of the MRI apparatus, where the two MSI acquisitions have alternating-sign readout gradients. The two MSI acquisitions are then processed and combined by the MRI apparatus using a weighted image combination to produce a final image.
FILED	Wednesday, March 14, 2018
APPL NO	15/921495
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4835 (20130101) G01R 33/5608 (20130101) G01R 33/56536 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 5/003 (20130101) G06T 2207/10088 (20130101) G06T 2207/20221 (20130101)
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10768406 — Imaging system

US 10768406	Xu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Scanogen Inc. (Baltimore, Maryland)
ASSIGNEE(S)	Scanogen Inc. (Baltimore, Maryland)
INVENTOR(S)	Zhiguang Xu (Malvern, Pennsylvania); Alfredo Andres Celedon (Columbia, Maryland)
ABSTRACT	An imaging system is described for measuring the position or movement of a particle having a size of less than about 20 microns. The system comprises an optional sample holder configured to hold a sample with a particle, an optional illumination source configured to illuminate the sample, a lens having a magnification ratio from about 1:5 to about 5:1 and configured to generate the image of the sample, an image sensor having a pixel size of up to about 20 microns and configured to sense the image of the sample, and an image processor operatively connected to the image sensor to process the image of the particle in order to determine the position or movement of the particle. The dimension of the image of each particle is at least about 1.5 times the dimension of the particle multiplied by the magnification ratio of the lens, and the image of each particle is distributed on at least two pixels of the sensor. The imaged area of the sample is at least about one millimeter squared.
FILED	Tuesday, February 28, 2017
APPL NO	15/444462
ART UNIT	2482 — Recording and Compression
CURRENT CPC	Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/04 (20130101) Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/16 (20130101) G02B 21/361 (20130101) Original (OR) Class G02B 21/365 (20130101)
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10769409 — Culture detection and measurement over time

US 10769409	Robinson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA)
APPLICANT(S)	Joseph Paul Robinson (West Lafayette, Indiana); Bartlomiej P. Rajwa (West Lafayette, Indiana); Valery Patsekin (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Joseph Paul Robinson (West Lafayette, Indiana); Bartlomiej P. Rajwa (West Lafayette, Indiana); Valery Patsekin (West Lafayette, Indiana)
ABSTRACT	A computer method for correlating depictions of colonies of microorganisms includes receiving an image of a substrate associated with a first time and showing a colony of microorganisms. A second image of the same substrate and associated with a second time shows a candidate colony of microorganisms. A region of the second image that shows the candidate colony of microorganisms is located. The first region of the first image is compared to the second region of the second image. Based on the comparison of the images, the candidate colony of microorganism is determined to be the same colony as the first colony of microorganisms. Systems for moving substrates having colonies of microorganisms and maintaining orientation of the substrates before and after movement are also described.
FILED	Thursday, April 21, 2016
APPL NO	15/567928
ART UNIT	2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00147 (20130101) Original (OR) Class G06K 9/6269 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 7/33 (20170101) G06T 2207/10056 (20130101) G06T 2207/30024 (20130101)
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10769432 — Automated parameterization image pattern recognition method

US 10769432	Jones et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	DRVision Technologies LLC (Bellevue, Washington)
ASSIGNEE(S)	DRVISION TECHNOLOGIES LLC (Bellevue, Washington)
INVENTOR(S)	Michael William Jones (Kenmore, Washington); Luciano Andre Guerreiro Lucas (Redmond, Washington); Hoyin Lai (Seattle, Washington); Casey James McBride (Kirkland, Washington); Shih-Jong James Lee (Bellevue, Washington)
ABSTRACT	A computerized automated parameterization image pattern detection and classification method performs (1) morphological metrics learning using labeled region data to generate morphological metrics; (2) intensity metrics learning using learning image and labeled region data to generate intensity metrics; and (3) population learning using the morphological metrics and the intensity metrics to generate learned pattern detection parameter. The method may further update the learned pattern detection parameter using additional labeled region data and learning image, and apply pattern detection with optional user parameter adjustment to image data to generate detected pattern. The method may alternatively perform pixel parameter learning and pixel classification to generate pixel class confidence, and uses the pixel class confidence and the labeled region data to perform pattern parameter learning to generate the learned pattern detection parameter. The method may further perform pattern classification learning to generate pattern classifier which is used to generate classified pattern.
FILED	Wednesday, October 10, 2018
APPL NO	16/156814
ART UNIT	2631 — Digital Communications
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00523 (20130101) G06K 9/00536 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/155 (20170101) G06T 7/187 (20170101)
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10769765 — Imaging systems and methods of using the same

US 10769765	Sobieranski et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Brigham and Women's Hospital Inc. (Boston, Massachusetts)
ASSIGNEE(S)	The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S)	Antonio C. Sobieranski (Florianopolis, Brazil); Utkan Demirci (Stanford, California); Huseyin C. Tekin (Bursa, Turkey); Fatih Inci (Palo Alto, California)
ABSTRACT	Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.
FILED	Monday, May 13, 2019
APPL NO	16/409979
ART UNIT	2426 — Cable and Television
CURRENT CPC	Holographic Processes or Apparatus G03H 1/265 (20130101) G03H 1/0443 (20130101) G03H 1/0866 (20130101) G03H 2001/0447 (20130101) G03H 2001/0825 (20130101) G03H 2001/2655 (20130101) G03H 2222/15 (20130101) G03H 2226/11 (20130101) G03H 2227/03 (20130101) G03H 2240/56 (20130101) Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 2207/20056 (20130101) G06T 2207/20221 (20130101) Pictorial Communication, e.g Television H04N 5/23232 (20130101)
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10769783 — Predicting prostate cancer biochemical recurrence using combined nuclear NF-KB/P65 localization and gland morphology

US 10769783	Madabhushi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Anant Madabhushi (Shaker Heights, Ohio); Patrick Leo (Honoeye Falls, New York); Andrew Janowczyk (East Meadow, New York); Sanjay Gupta (Mayfield Heights, Ohio)
ABSTRACT	Embodiments include controlling a processor to perform operations for predicting biochemical recurrence (BCR) in prostate cancer (PCa), including accessing a first digitized pathology slide having a first stain channel of a region of tissue demonstrating PCa; accessing a second digitized pathology slide having a second, different stain channel of the region of tissue; extracting morphology features from the first stain channel; extracting stain intensity features from the second stain channel, where a stain intensity feature quantifies an amount of a molecular biomarker present in a cellular nucleus; controlling a first machine learning classifier to generate a first probability of BCR based on the morphology features; controlling a second machine learning classifier to generate a second, different probability of BCR based on the stain intensity features; computing an aggregate probability of BCR based on the first probability and the second probability; and displaying the aggregate probability.
FILED	Wednesday, December 12, 2018
APPL NO	16/217274
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/6202 (20130101) G06K 9/6223 (20130101) G06K 9/6277 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20036 (20130101) G06T 2207/20081 (20130101) G06T 2207/30024 (20130101)
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10770169 — Method of providing a treatment to a subject based on a dynamic pathway map

US 10770169	Vaske et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI)
APPLICANT(S)	Charles J. Vaske (Santa Cruz, California); Stephen C. Benz (Santa Cruz, California); Joshua M. Stuart (Santa Cruz, California); David Haussler (Santa Cruz, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Charles J. Vaske (Santa Cruz, California); Stephen C. Benz (Santa Cruz, California); Joshua M. Stuart (Santa Cruz, California); David Haussler (Santa Cruz, California)
ABSTRACT	The present invention relates to methods for evaluating the probability that a patient's diagnosis may be treated with a particular clinical regimen or therapy.
FILED	Friday, April 29, 2011
APPL NO	13/068002
ART UNIT	3619 — Semiconductors/Memory
CURRENT CPC	Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class G16B 25/00 (20190201) G16B 40/00 (20190201) Technologies for Adaptation to Climate Change Y02A 90/26 (20180101)
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10770276 — Techniques of mass spectrometry for isotopomer analysis and related systems and methods

US 10770276	Kibbey et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	Yale University (New Haven, Connecticut)
INVENTOR(S)	Richard Kibbey (Hamden, Connecticut); Tiago Cardoso Alves (New Haven, Connecticut); Graeme F. Mason (Guilford, Connecticut)
ABSTRACT	According to some aspects, a spectrometer is provided, the spectrometer configured to receive molecules of a plurality of metabolites including one or more molecules of a first metabolite, filter the received molecules to retain molecules of the first metabolite including a plurality of different mass isotopomers of the first metabolite, fragment molecules of a first mass isotopmer of the retained molecules to produce a first plurality of daughter ions, measure abundances of the first plurality of daughter ions as a function of daughter ion mass, fragment molecules of a second istopomer, different from the first mass isotopmer, of the retained molecules to produce a second plurality of daughter ions, and measure abundances of the second plurality of daughter ions as a function of the daughter ion mass.
FILED	Tuesday, August 30, 2016
APPL NO	15/755641
ART UNIT	2881 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/622 (20130101) G01N 33/6848 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0031 (20130101) H01J 49/0036 (20130101) H01J 49/0045 (20130101) Original (OR) Class H01J 49/421 (20130101)
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Department of Defense (DOD)

10765363 — Headgear for dry electroencephalogram sensors

US 10765363	Kerth et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA)
APPLICANT(S)	Trevor Austin Kerth (London, United Kingdom); Yu Mike Chi (San Diego, California); Aileen Ngoc Tran (San Diego, California)
ASSIGNEE(S)	Cognionics, Inc. (San Diego, California)
INVENTOR(S)	Trevor Austin Kerth (London, United Kingdom); Yu Mike Chi (San Diego, California); Aileen Ngoc Tran (San Diego, California)
ABSTRACT	A headgear for placing sensors on a subject's head includes a centerpiece; a plurality of arms attached to and radiating outward and generally downward from the centerpiece; and sensor tips attached to the dorsal ends of at least some of the arms. At least one of the plurality of arms is a lower arm that is elastic and/or spring-like. When the headgear is placed on a subject's head, the at least one lower arm is so disposed in relation to the maximum circumference of the subject's head that the at least one lower arm must be bent outward for placement of the headgear on the subject's head and thereby provide a reactive force toward the head that causes the at least one lower arm to grasp at least a portion of the head that is at and/or below the maximum circumference of the head.
FILED	Friday, October 21, 2016
APPL NO	15/299953
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Hats; Head Coverings A42B 1/242 (20130101) Diagnosis; Surgery; Identification A61B 5/0478 (20130101) A61B 5/6803 (20130101) Original (OR) Class A61B 5/7225 (20130101) A61B 2562/04 (20130101)
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10765376 — Method and apparatus to diagnose the metastatic or progressive potential of cancer, fibrosis and other diseases

US 10765376	Brown, III et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	University of Rochester (Rochester, New York)
ASSIGNEE(S)	University of Rochester (Rochester, New York)
INVENTOR(S)	Edward Bernard Brown, III (Honeoye Falls, New York); Seth Warrington Perry (Pittsford, New York); Kathleen Anne Burke (Rockville Centre, New York); Robert Matthew Kottmann (Rochester, New York); Patricia Janet Sime (Pittsford, New York); Jesse Wakefield Sharp (Rochester, New York)
ABSTRACT	A method and apparatus for determining the progressive potential of a disease is disclosed. The forward to backward propagating second harmonic generation signal derived from a second harmonic generation instrument is used to assess the collagen microstructure of imaged body tissue by way of numerical values that are in turn used to determine the progressive or metastatic potential of the disease. The disease may, for example, be a cancer such as breast cancer, lung fibrosis, colorectal adenocarcinoma, or the like. The apparatus may include in vivo instruments or laboratory diagnostic instruments with methods disclosed herein.
FILED	Tuesday, April 07, 2015
APPL NO	15/302423
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/04 (20130101) A61B 5/0071 (20130101) A61B 5/0075 (20130101) A61B 5/0084 (20130101) A61B 5/4842 (20130101) A61B 5/4887 (20130101) A61B 5/7275 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/636 (20130101) G01N 21/6486 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/37 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/30 (20180101)
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10765399 — Programmable electronic stethoscope devices, algorithms, systems, and methods

US 10765399	Emmanouilidou et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Science Foundation (NSF)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Dimitra Emmanouilidou (Baltimore, Maryland); James E. West (Baltimore, Maryland); Mounya Elhilali (North Potomac, Maryland); Ian Mclane (Baltimore, Maryland)
ABSTRACT	A digital electronic stethoscope includes an acoustic sensor assembly that includes a body sensor portion and an ambient sensor portion, the body sensor portion being configured to make acoustically coupled contact with a subject while the ambient sensor portion is configured to face away from the body sensor portion so as to capture environmental noise proximate the body sensor portion; a signal processor and data storage system configured to communicate with the acoustic sensor assembly so as to receive detection signals therefrom, the detection signals including an auscultation signal comprising body target sound and a noise signal; and an output device configured to communicate with the signal processor and data storage system to provide at least one of an output signal or information derived from the output signal. The signal processor and data storage system includes a noise reduction system that removes both stationary noise and non-stationary noise from the detection signal to provide a clean auscultation signal substantially free of distortions. The signal processor and data storage system further includes an auscultation sound classification system configured to receive the clean auscultation signal and provide a classification thereof as at least one of a normal breath sound or an abnormal breath sound.
FILED	Monday, October 31, 2016
APPL NO	15/772454
ART UNIT	2655 — Digital Audio Data Processing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/7203 (20130101) A61B 5/7264 (20130101) A61B 7/003 (20130101) A61B 7/04 (20130101) Original (OR) Class A61B 7/026 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) G06N 99/00 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/178 (20130101) G10K 2210/116 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/51 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101)
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10765400 — Vascular targeting system

US 10765400	Blackbourne et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Institute of Surgical Research (USAISR) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	The Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland)
ASSIGNEE(S)	The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland)
INVENTOR(S)	Lorne H. Blackbourne (Houston, Texas); Jose Salinas (Houston, Texas); Ronald D. Grisell (Fort Sam Houston, Texas)
ABSTRACT	An embodiment of the invention provides a method including obtaining ultrasonic images of one or more vessel to be catheterized with an ultrasonic imaging device 212 and identifying the center(s) of the vessel(s) with the ultrasonic images. One of the vessels is punctured with a needle 220 based on the identifying of the center of the vessel. A guide wire 230 is inserted into the vessel and maneuvered with guide wire ultrasonic feedback control. The guide wire ultrasonic feedback control includes obtaining ultrasonic images of the vessel and the guide wire 230 in the vessel, and displaying the ultrasonic images of the vessel and the guide wire 230 in the vessel to a user. A catheter sheath 240 is inserted over the guide wire 230 and maneuvered with sheath ultrasonic feedback control. The guide wire 230 is removed and a catheter 250 is inserted into the catheter sheath 240 and maneuvered with catheter ultrasonic feedback control.
FILED	Monday, April 25, 2016
APPL NO	15/568974
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/489 (20130101) A61B 8/06 (20130101) A61B 8/0841 (20130101) A61B 8/0891 (20130101) Original (OR) Class
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10765477 — Microwave ablation antenna system

US 10765477	Behdad et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Nader Behdad (Madison, Wisconsin); Susan C. Hagness (Madison, Wisconsin); Hung Thanh Luyen (Madison, Wisconsin)
ABSTRACT	An antenna system is provided. The antenna system includes a coaxial cable, an antenna, and an impedance matching structure. The coaxial cable includes a center conductor extending a length of the coaxial cable, a dielectric material surrounding the center conductor along the length of the coaxial cable, and a conductive shield surrounding the dielectric material along the length of the coaxial cable. The antenna includes a conductor having an electrical length of half a wavelength at a selected operating frequency. The impedance matching structure includes a second center conductor mounted between an end of the center conductor of the coaxial cable and a feed end of the antenna. The impedance matching structure is configured to match an impedance of the coaxial cable to an impedance of the antenna.
FILED	Monday, March 10, 2014
APPL NO	14/202786
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/1815 (20130101) Original (OR) Class A61B 2018/00529 (20130101) A61B 2018/00577 (20130101) A61B 2018/1846 (20130101) A61B 2018/1853 (20130101) A61B 2018/1892 (20130101) Antennas, i.e Radio Aerials H01Q 9/42 (20130101)
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10765581 — Spool for winch actuator

US 10765581	Mooney et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Natick Soldier Research, Development and Engineering Center (NSRDEC)
APPLICANT(S)	Dephy, Inc. (Maynard, Massachusetts)
ASSIGNEE(S)	Dephy, Inc. (Maynard, Massachusetts)
INVENTOR(S)	Luke Mooney (Sudbury, Massachusetts); Jean-Francois Duval (Belmont, Massachusetts); William Marvin (Canton, Massachusetts)
ABSTRACT	A spool assembly and method of use is disclosed having generally a first and a second mating portions which can mate along a longitudinal axis of the spool to retain a belt therein. The mating surfaces of the first and second mating portions can take a variety of geometries or splines which can efficiently retain the belt while maintaining a suitable transmission ratio. In an exemplary embodiment, the spool exit curve for the retained belt can be radially inward of a majority of the spool to reduce the overall diameter of the spool. In some exemplary embodiments, the spool can be mounted within a motor and rotated thereby to spool and unspool the belt.
FILED	Tuesday, March 26, 2019
APPL NO	16/365079
ART UNIT	3654 — Material and Article Handling
CURRENT CPC	Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0237 (20130101) Original (OR) Class A61H 3/00 (20130101) A61H 2003/007 (20130101) A61H 2201/165 (20130101) A61H 2205/106 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) Capstans; Winches; Tackles, e.g Pulley Blocks; Hoists B66D 1/34 (20130101)
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10765627 — Immunogenic composition against Campylobacter jejuni

US 10765627	Guerry et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Patricia Guerry (Silver Spring, Maryland); Mario Artur Monteiro (Guelph, Canada)
ABSTRACT	The inventive subject matter relates to an immunogenic composition against Campylobacter jejuni comprising isolated capsule polysaccharide from selected pathogenic Campylobacter jejuni strains. The inventive subject matter also relates to methods of using the polysaccharide compositions in inducing an anti-C. jejuni immune response.
FILED	Wednesday, June 12, 2019
APPL NO	16/438743
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Original (OR) Class A61K 31/715 (20130101) A61K 39/105 (20130101) A61K 47/646 (20170801) A61K 47/6415 (20170801) A61K 2039/6037 (20130101) A61K 2039/55505 (20130101) Technologies for Adaptation to Climate Change Y02A 50/47 (20180101)
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10765781 — In situ forming hemostatic foam implants

US 10765781	Sharma et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	ARSENAL MEDICAL, INC. (Watertown, Massachusetts)
ASSIGNEE(S)	Arsenal Medical Inc. (Watertown, Massachusetts)
INVENTOR(S)	Upma Sharma (Somerville, Massachusetts); Irina Gitlin (San Francisco, California); Gregory T. Zugates (Chelmsford, Massachusetts); Adam Rago (Falmouth, Massachusetts); Parisa Zamiri (Brookline, Massachusetts); Rany Busold (Medford, Massachusetts); Toby Freyman (Waltham, Massachusetts); Robert J. Caulkins (Watertown, Massachusetts); Quynh P Pham (Methuen, Massachusetts); Changcheng You (Burlington, Massachusetts); Jeffrey D. Carbeck (Belmont, Massachusetts)
ABSTRACT	Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
FILED	Thursday, July 06, 2017
APPL NO	15/642968
ART UNIT	3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/12031 (20130101) A61B 17/12163 (20130101) A61B 17/12186 (20130101) A61B 2017/12004 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/2093 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/18 (20130101) A61L 27/18 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 31/06 (20130101) Original (OR) Class A61L 31/06 (20130101) A61L 31/141 (20130101) A61L 31/146 (20130101) A61L 31/148 (20130101) A61L 2400/04 (20130101) A61L 2400/06 (20130101) A61L 2400/18 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/00 (20130101) Compositions of Macromolecular Compounds C08L 63/00 (20130101) C08L 63/00 (20130101) C08L 67/04 (20130101) C08L 67/04 (20130101)
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10765865 — Implants using ultrasonic waves for stimulating tissue

US 10765865	Maharbiz et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Michel M. Maharbiz (El Cerrito, California); Dongjin Seo (Albany, California); Konlin Shen (Oakland, California); Jose M. Carmena (Berkeley, California); Ryan Neely (El Cerrito, California); Elad Alon (Oakland, California); Jan Rabaey (Berkeley, California)
ABSTRACT	Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal. Further described are computer systems useful for operating one or more implantable devices, as well as methods of electrically stimulating a tissue.
FILED	Wednesday, May 01, 2019
APPL NO	16/401060
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0031 (20130101) A61B 5/076 (20130101) A61B 5/686 (20130101) A61B 5/4836 (20130101) A61B 6/4258 (20130101) A61B 8/48 (20130101) A61B 8/085 (20130101) A61B 8/0808 (20130101) A61B 8/0875 (20130101) A61B 2560/0219 (20130101) A61B 2562/12 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2205/04 (20130101) A61M 2205/825 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/372 (20130101) A61N 1/0534 (20130101) A61N 1/3605 (20130101) Original (OR) Class A61N 1/3787 (20130101) A61N 1/37205 (20130101) A61N 5/1071 (20130101) A61N 7/02 (20130101) A61N 2005/1087 (20130101) A61N 2007/0021 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/025 (20130101) H02J 50/15 (20160201)
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10765869 — Precision delivery of electrical stimulation

US 10765869	Carlson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON)
APPLICANT(S)	Medtronic, Inc. (Minneapolis, Minnesota)
ASSIGNEE(S)	Medtronic, Inc. (Minneapolis, Minnesota)
INVENTOR(S)	David L. Carlson (Fridley, Minnesota); Heather D. Orser (Farmington, Minnesota); Dale G. Suilmann (Elk River, Minnesota); Kenneth J. Gutzman (Lino Lakes, Minnesota); Gregory J. Loxtercamp (Edina, Minnesota)
ABSTRACT	An example method for controlling delivery of electrical stimulation therapy includes maintaining, by one or more processors of a medical device configured to deliver electrical stimulation to a patient, a counter tied to a clock used by the medical device to deliver the electrical stimulation to the patient; and obtaining, by the one or more processors, one or more representations of sensed electrical signals for the patient that are referenced to counts of the counter. In this example, the method also includes identifying, based on the one or more representations of the sensed electrical signals for the patient, a count of the counter at which stimulation is to be delivered to the patient; and delivering, by the medical device and to the patient, electrical stimulation based on the identified count of the counter.
FILED	Wednesday, December 20, 2017
APPL NO	15/848291
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/04 (20130101) A61B 5/0478 (20130101) A61B 5/7275 (20130101) A61B 5/7282 (20130101) A61B 5/7285 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/08 (20130101) A61N 1/0534 (20130101) A61N 1/0551 (20130101) A61N 1/3616 (20130101) A61N 1/36132 (20130101) A61N 1/36139 (20130101) A61N 1/36167 (20130101) Original (OR) Class A61N 1/37211 (20130101) A61N 1/37264 (20130101) A61N 1/37288 (20130101)
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10766024 — Multicomponent plasmonic photocatalysts consisting of a plasmonic antenna and a reactive catalytic surface: the antenna-reactor effect

US 10766024	Halas et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE)
APPLICANT(S)	William Marsh Rice University (Houston, Texas)
ASSIGNEE(S)	William Marsh Rice University (Houston, Texas)
INVENTOR(S)	Nancy Jean Halas (Houston, Texas); Peter Nordlander (Houston, Texas); Hossein Robatjazi (Houston, Texas); Dayne Francis Swearer (Houston, Texas); Chao Zhang (Houston, Texas); Hangqi Zhao (Houston, Texas); Linan Zhou (Houston, Texas)
ABSTRACT	A multicomponent photocatalyst includes a reactive component optically, electronically, or thermally coupled to a plasmonic material. A method of performing a catalytic reaction includes loading a multicomponent photocatalyst including a reactive component optically, electronically, or thermally coupled to a plasmonic material into a reaction chamber, introducing molecular reactants into the reaction chamber, and illuminating the reaction chamber with a light source.
FILED	Friday, May 11, 2018
APPL NO	15/977843
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/123 (20130101) B01J 19/127 (20130101) B01J 21/04 (20130101) B01J 23/002 (20130101) B01J 23/38 (20130101) B01J 23/44 (20130101) B01J 23/50 (20130101) B01J 23/52 (20130101) B01J 23/58 (20130101) B01J 23/72 (20130101) B01J 23/78 (20130101) B01J 23/8926 (20130101) B01J 23/8946 (20130101) B01J 27/04 (20130101) B01J 27/14 (20130101) B01J 27/20 (20130101) B01J 27/22 (20130101) B01J 27/24 (20130101) B01J 31/06 (20130101) B01J 31/1691 (20130101) B01J 35/002 (20130101) B01J 35/004 (20130101) Original (OR) Class B01J 35/0006 (20130101) B01J 35/006 (20130101) B01J 35/008 (20130101) B01J 35/0013 (20130101) B01J 35/0033 (20130101) B01J 35/1066 (20130101) B01J 37/03 (20130101) B01J 37/0203 (20130101) B01J 37/0225 (20130101) B01J 37/344 (20130101) B01J 2219/00635 (20130101) B01J 2523/00 (20130101) B01J 2523/00 (20130101) B01J 2523/17 (20130101) B01J 2523/22 (20130101) B01J 2523/31 (20130101) B01J 2523/821 (20130101) B01J 2540/66 (20130101)
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10766071 — Extreme creep resistant nano-crystalline metallic materials

US 10766071	Kecskes et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Laszlo J. Kecskes (Havre De Grace, Maryland); Kristopher A. Darling (Havre De Grace, Maryland); Rajiv S. Mishra (Denton, Texas); Yuri Mishin (Centreville, Virginia); Kiran N. Solanki (Tempe, Arizona); Mansa Rajagopalan (San Ramon, California)
ABSTRACT	Novel metallic systems and methods for their fabrication provide an extreme creep-resistant nano-crystalline metallic material. The material comprises a matrix formed of a solvent metal with crystalline grains having diameters of no more than about 500 nm, and a plurality of dispersed metallic particles formed on the basis of a solute metal in the solvent metal matrix and having diameters of no more than about 200 nm. The particle density along the grain boundary of the matrix is as high as about 2 nm²of grain boundary area per particle so as to substantially block grain boundary motion and rotation and limit creep at temperatures above 35% of the melting point of the material.
FILED	Wednesday, February 14, 2018
APPL NO	15/896804
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0044 (20130101) B22F 1/0044 (20130101) B22F 3/20 (20130101) B22F 9/002 (20130101) Original (OR) Class B22F 9/04 (20130101) B22F 9/12 (20130101) B22F 9/14 (20130101) B22F 2009/041 (20130101) B22F 2009/043 (20130101) B22F 2009/043 (20130101) B22F 2202/03 (20130101) B22F 2202/03 (20130101) B22F 2301/10 (20130101) B22F 2301/25 (20130101) B22F 2301/35 (20130101) B22F 2301/155 (20130101) B22F 2301/205 (20130101) B22F 2304/054 (20130101) B22F 2999/00 (20130101) B22F 2999/00 (20130101) B22F 2999/00 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Alloys C22C 1/0425 (20130101) C22C 1/0425 (20130101) C22C 9/00 (20130101) C22C 2200/04 (20130101) C22C 2202/00 (20130101)
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10766579 — Passive heave compensated davit

US 10766579	Kerns, IV
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	United States of America as Represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Maris Vernon Kerns, IV (Hayes, Virginia)
ABSTRACT	The invention is directed towards a passive heave compensation arrangement for compensating for heave events in the open water, when loading or offloading/launching objects. The arrangement is part of a system that includes a water vessel that is operating on open water, a davit, and an object to be loaded/offloaded. The davit includes a stanchion, a boom, and a capture head for capturing objects within the head. The arrangement includes first and second winches, as well as a gas spring that applies forces to the boom in response to heave events, the gas spring as a part of the arrangement, passively compensating for every heave event.
FILED	Tuesday, April 09, 2019
APPL NO	16/379362
ART UNIT	3617 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Ships or Other Waterborne Vessels; Equipment for Shipping B63B 23/04 (20130101) B63B 39/02 (20130101) Original (OR) Class
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10766830 — Compositions with solid fuel loaded on graphene foams

US 10766830	Jain et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Shourya Jain (West Lafayette, Indiana); Li Qiao (West Lafayette, Indiana)
ABSTRACT	The present application generally relates to compositions with solid fuel loaded on graphene foams (GFs) for enhanced burn rates, and methods of making and using the compositions with solid fuel loaded on graphene foam.
FILED	Friday, March 23, 2018
APPL NO	15/933452
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 32/182 (20170801) C01B 32/184 (20170801) C01B 32/186 (20170801) C01B 2204/04 (20130101) C01B 2204/32 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0083 (20130101) C06B 23/007 (20130101) C06B 25/06 (20130101) Original (OR) Class C06B 25/34 (20130101) C06B 47/145 (20130101)
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10767053 — Oxygen scavenging polyester compositions for containers

US 10767053	Ferrari et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Aberdeen Proving Ground (APG)
APPLICANT(S)	APG Polytech, LLC (Wilmington, Delaware)
ASSIGNEE(S)	APG Polytech, LLC (Wilmington, Delaware)
INVENTOR(S)	Gianluca Ferrari (Portograuaro, Italy); D. Jeffrey Black (Akron, Ohio)
ABSTRACT	Disclosed herein is an oxygen scavenging composition for containers. The oxygen scavenging composition for containers may comprise at least one polyester component, a transition metal catalyst, an oxygen scavenger, and a vegetable oil. The vegetable oil preferably comprises at least one molecule having a double allylic structure. The polyester component preferably comprises at least one acid unit and at least one diol unit. The concentration of double allylic structures of the vegetable oil in the composition may be greater than 5.0 meq/kg of all of the polyester components. The oxygen scavenger is preferably present in the composition at a level less than 1.0% by weight of the total composition. The vegetable oil is preferably present in the composition at a level greater than 0.3% by weight relative to the total weight of the polyester components, the transition metal catalyst and the vegetable oil.
FILED	Friday, September 13, 2019
APPL NO	16/569732
ART UNIT	1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 49/0005 (20130101) B29C 49/06 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2067/003 (20130101) B29K 2105/0014 (20130101) B29K 2995/0053 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7158 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) C08K 5/20 (20130101) C08K 5/098 (20130101) C08K 5/103 (20130101) C08K 5/103 (20130101) C08K 5/103 (20130101) C08K 5/103 (20130101) C08K 5/3445 (20130101) C08K 11/00 (20130101) C08K 2003/2241 (20130101) C08K 2201/012 (20130101) Compositions of Macromolecular Compounds C08L 67/02 (20130101) C08L 67/02 (20130101) C08L 67/02 (20130101) C08L 67/02 (20130101) C08L 67/02 (20130101) C08L 67/02 (20130101) C08L 67/03 (20130101) C08L 77/06 (20130101) C08L 77/06 (20130101) C08L 91/00 (20130101) Original (OR) Class C08L 91/00 (20130101) C08L 2201/08 (20130101) C08L 2203/10 (20130101) C08L 2203/16 (20130101)
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10767179 — MicroRNA composition for the treatment of neuroblastoma

US 10767179	Du
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	Liqin Du (San Antonio, Texas)
ASSIGNEE(S)	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Liqin Du (San Antonio, Texas)
ABSTRACT	Certain embodiments are directed to methods of identifying neuroblastoma differentiation-inducing compounds or agent and their use in treating neuroblastoma.
FILED	Monday, October 01, 2018
APPL NO	16/148466
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/713 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101)
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10767256 — Method of engineering single phase magnetoelectric hexaferrite films

US 10767256	Vittoria
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Carmine Vittoria (Key Biscayne, Florida)
ASSIGNEE(S)
INVENTOR(S)	Carmine Vittoria (Key Biscayne, Florida)
ABSTRACT	A method of making a ferrite thin film is provided in which a portion of the iron ions in the ferrite are substituted by ions of at least one other metal. The substituting ions occupy both tetrahedral and octahedral sites in the unit cell of the ferrite crystal. The method includes placing each of a plurality of targets, one at a time, in close proximity to a substrate in a defined sequence; ablating the target thus placed using laser pulses, thereby causing ions from the target to deposit on the substrate; repeating these steps, thereby generating a film; and annealing the film in the presence of oxygen. The plurality of targets, the sequence of their ablation, and the number of laser pulses that each target is subjected to, are selected so as to allow the substituting ions to occupy both tetrahedral and octahedral sites in the unit cell.
FILED	Wednesday, December 14, 2016
APPL NO	15/378998
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/08 (20130101) C23C 14/28 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/20 (20130101) H01F 41/205 (20130101)
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10767485 — Radial cooling system for gas turbine engine compressors

US 10767485	Bintz et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Matthew E Bintz (West Hartford, Connecticut); Enzo DiBenedetto (Berlin, Connecticut); Paul E Coderre (East Hampton, Connecticut)
ABSTRACT	A gas turbine engine is disclosed. The gas turbine engine includes a first rotor supporting a first plurality of circumferentially spaced rotor blades and a second rotor disposed axially downstream of the first rotor and supporting a second plurality of circumferentially spaced rotor blades, a first bore cavity between the first rotor and the second rotor, a first fluid passageway configured to provide cooled air to the first bore cavity and a first anti-vortex component positioned proximate the first bore cavity and configured to increase pressure of the cooled air as the cooled air traverses radially outward from the first bore cavity.
FILED	Monday, January 08, 2018
APPL NO	15/864925
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/06 (20130101) F01D 5/087 (20130101) Original (OR) Class F01D 11/001 (20130101) F01D 11/02 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/18 (20130101) F02C 7/141 (20130101) Non-positive-displacement Pumps F04D 29/321 (20130101) F04D 29/582 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2210/12 (20130101) F05D 2220/3218 (20130101) F05D 2220/3219 (20130101) F05D 2240/11 (20130101) F05D 2240/12 (20130101) F05D 2240/24 (20130101) F05D 2240/55 (20130101) F05D 2260/20 (20130101) F05D 2260/209 (20130101) F05D 2260/213 (20130101)
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10767486 — Mistuned concentric airfoil assembly and method of mistuning same

US 10767486	Hayford et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Richard K. Hayford (Cap Neddick, Maine); Steven J. Ford (Sanford, Maine)
ABSTRACT	An airfoil assembly for a gas turbine engine according to an example of the present disclosure includes, among other things, an annular shroud having a radially inner face and a radially outer face opposing the radially inner face, a radially inner array of airfoils extending from the radially inner face, and a radially outer array of airfoils extending from the radially outer face. The radially inner array of airfoils are configured to guide flow within a radially inner bypass flow passage, the radially inner bypass flow passage bypassing and being radially outward of a compressor section. At least one, but fewer than each, airfoil of the radially inner array of airfoils is circumferentially aligned with a corresponding airfoil in the radially outer array of airfoils, and the remaining airfoils in the radially inner array of airfoils are misaligned with the airfoils of the radially outer array of airfoils. A method of reducing a vibratory response of airfoils is also disclosed.
FILED	Tuesday, August 21, 2018
APPL NO	16/106221
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/022 (20130101) F01D 5/146 (20130101) Original (OR) Class F01D 5/225 (20130101) F01D 25/06 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/961 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/673 (20130101)
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10767507 — Foreign object debris trending concept and design

US 10767507	Khibnik et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Alexander I Khibnik (Glastonbury, Connecticut); Gregory S Hagen (Glastonbury, Connecticut)
ABSTRACT	A system and method for detecting foreign object debris damage is disclosed. A method for foreign object debris detection in a gas turbine engine may include receiving, by a controller, a first time-series data from a database, wherein the first time-series data comprises a feature, pre-processing, by the controller, the first time-series data to generate a second time-series data, generating a third time-series data via an anomaly detector model, sending, by the controller, the third time-series data to a foreign object debris (FOD) damage model, and determining, by the controller, that a FOD event has occurred based on data received from the FOD damage model. In various embodiments, the method may further comprise generating, by the controller, a health report (HR).
FILED	Monday, November 14, 2016
APPL NO	15/350886
ART UNIT	2853 — Printing/Measuring and Testing
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 21/003 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/05 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2260/80 (20130101) F05D 2260/81 (20130101) F05D 2260/83 (20130101) F05D 2260/607 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 15/14 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 23/0221 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/675 (20130101)
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10767560 — Bearing compartment oil auto-ignition mitigation

US 10767560	Rogers et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Daniel S. Rogers (Lyman, Maine); Taryn Narrow (Glastonbury, Connecticut); Gregory E. Reinhardt (South Glastonbury, Connecticut); Collin P. Fitzgerald (South Glastonbury, Connecticut); Christopher M. Valva (Manchester, Connecticut); Leonard Kolshak (Lake Worth, Florida)
ABSTRACT	A bearing assembly for a gas turbine engine includes, among other things, a bearing housing extending along an axis to define a bearing compartment, a lubricant seal assembly adjacent to the bearing housing to bound the bearing compartment, an air seal assembly defining a vent cavity along the bearing housing, wherein a mixing cavity is defined between the lubricant seal assembly and the air seal assembly, and wherein the bearing housing defines an airflow supply passage, an airflow vent passage and a scupper passage having respective fluid ports at different circumferential positions relative to the axis, the fluid port of the airflow vent passage fluidly coupled to the vent cavity, and the fluid ports of the airflow supply and scupper passages fluidly coupled to the mixing cavity. A method of sealing for a gas turbine engine is also disclosed.
FILED	Tuesday, September 11, 2018
APPL NO	16/127365
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/06 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/50 (20130101) F05D 2240/55 (20130101) F05D 2260/98 (20130101) Lubricating F16N 2210/02 (20130101) F16N 2210/08 (20130101) F16N 2210/14 (20130101)
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10767867 — Bearing support assembly

US 10767867	Davis et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Todd A. Davis (Tolland, Connecticut); Christopher M. Valva (Manchester, Connecticut); Daniel Rosen (Meriden, Connecticut); Armando Amador (Wethersfield, Connecticut); Aneil S. Hegde (Vernon, Connecticut); Ramin M. Rafatpanah (Windsor, Connecticut)
ABSTRACT	A bearing support may include a central shaft, a flange shaft, and a tube boss. The central shaft may include a central longitudinal axis extending between a first end and a second end of the bearing support. The flange shaft may extend radially outward of the central shaft at an acute angle, relative to the central longitudinal axis from the first end to the second end, and the flange shaft may include a rim defining an aperture. The tube boss extends from the central shaft radially outward through the aperture, according to various embodiments. An annular channel may be between the rim and the tube boss.
FILED	Wednesday, March 21, 2018
APPL NO	15/927285
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/065 (20130101) F01D 11/003 (20130101) F01D 25/162 (20130101) F01D 25/164 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/28 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/58 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/60 (20130101) Original (OR) Class F23R 2900/00012 (20130101)
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10768059 — Embedded optical probe for gas turbine engine

US 10768059	Warren et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Eli Cole Warren (Wethersfield, Connecticut); Michael F. Sabol (Port St. Lucie, Florida)
ABSTRACT	An optical probe for a gas turbine engine includes a housing. Also included is a plurality of optical fibers, a portion of each of the optical fibers secured to fiber holders. Further included is an optical head disposed within the housing and having channels extending in a longitudinal direction of the optical head, the fiber holders disposed within the channels. Yet further included is a cap disposed within the housing and operatively coupled to the optical head, the plurality of optical fibers extending through the cap. Also included is an inner tube operatively coupled to the cap, the plurality of fibers extending through the inner tube.
FILED	Friday, February 16, 2018
APPL NO	15/932263
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 17/02 (20130101) Jet-propulsion Plants F02K 3/06 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2260/83 (20130101) F05D 2270/804 (20130101) Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/004 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/242 (20130101) Original (OR) Class G01L 1/247 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 15/14 (20130101)
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10768080 — Method of purifying tumor cells using shear stress

US 10768080	Henry et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
ASSIGNEE(S)	University of Iowa Research Foundation (Iowa City, Iowa)
INVENTOR(S)	Michael D. Henry (Iowa City, Iowa); J. Matthew Barnes (Iowa City, Iowa)
ABSTRACT	Methods for isolating viable cancer cells from a sample that comprises a mixture of cancerous cells and normal (non-cancerous) cells are provided. In the methods, a fluid preparation comprising a mixture of cancerous and normal cells is repeatedly exposed to fluid shear stresses, whereby the repeated exposure to the fluid shear stresses preferentially imparts fluid shear stress-resistance to the cancerous cells.
FILED	Monday, April 02, 2018
APPL NO	15/943187
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 2200/027 (20130101) B01L 2200/0647 (20130101) B01L 2400/0475 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 2521/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) Original (OR) Class G01N 33/487 (20130101) G01N 33/574 (20130101) G01N 33/5026 (20130101) G01N 33/5044 (20130101) G01N 33/5091 (20130101)
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10768092 — Measurement systems and methods for corrosion testing of coatings and materials

US 10768092	Friedersdorf et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Luna Innovations Incorporated (Roanoke, Virginia)
ASSIGNEE(S)	Luna Innovations Incorporated (Roanoke, Virginia)
INVENTOR(S)	Fritz John Friedersdorf (Earlysville, Virginia); Conrad Koenig Andrews (Charlottesville, Virginia); Paul Gordon Muskopf (Charlottesville, Virginia); Kathryn Beryl Ridder (Pittsburgh, Pennsylvania)
ABSTRACT	A measurement system permits environmental, corrosion damage, and mechanical property measurements to assess protection properties of coatings. The system includes one or more multi-sensor panels, each multi-sensor panel having sensors for assessing coating barrier properties, free corrosion, and galvanic corrosion. Each multi-sensor panel is installed on a test rack that contains electronics for sensor excitation and sensor data acquisition throughout a corrosion test. Sensor data is collected, stored, and communicated to a base station. A network of multiple test racks can be supported by a base station to compare the performance of different coatings and material combinations simultaneously. The test racks can be used in accelerated atmospheric corrosion tests, outdoor test sites, or application service environments. Measurements of the capacity of a coating to maintain barrier properties, prevent free corrosion, galvanic corrosion, and environment-assisted cracking can be used to develop, select, and predict service performance of coatings.
FILED	Thursday, September 25, 2014
APPL NO	14/496164
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/02 (20130101) G01N 3/06 (20130101) G01N 3/08 (20130101) G01N 3/20 (20130101) G01N 17/02 (20130101) G01N 17/04 (20130101) Original (OR) Class G01N 17/043 (20130101) G01N 19/04 (20130101) G01N 27/20 (20130101) G01N 27/22 (20130101) G01N 27/023 (20130101) G01N 27/041 (20130101) G01N 33/0031 (20130101) G01N 2203/024 (20130101)
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10768093 — Measurement systems and methods for corrosion testing of coatings and materials

US 10768093	Friedersdorf et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Luna Innovations Incorporated (Roanoke, Virginia)
ASSIGNEE(S)	Luna Innovations Incorporated (Roanoke, Virginia)
INVENTOR(S)	Fritz John Friedersdorf (Earlysville, Virginia); Conrad Koenig Andrews (Charlottesville, Virginia); Paul Gordon Muskopf (Charlottesville, Virginia); Kathryn Beryl Ridder (Pittsburgh, Pennsylvania)
ABSTRACT	A measurement system permits environmental, corrosion damage, and mechanical property measurements to assess protection properties of coatings. The system includes one or more multi-sensor panels, each multi-sensor panel having sensors for assessing coating barrier properties, free corrosion, and galvanic corrosion. Each multi-sensor panel is installed on a test rack that contains electronics for sensor excitation and sensor data acquisition throughout a corrosion test. Sensor data is collected, stored, and communicated to a base station. A network of multiple test racks can be supported by a base station to compare the performance of different coatings and material combinations simultaneously. The test racks can be used in accelerated atmospheric corrosion tests, outdoor test sites, or application service environments. Measurements of the capacity of a coating to maintain barrier properties, prevent free corrosion, galvanic corrosion, and environment-assisted cracking can be used to develop, select, and predict service performance of coatings.
FILED	Thursday, April 06, 2017
APPL NO	15/480609
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/02 (20130101) G01N 3/06 (20130101) G01N 3/08 (20130101) G01N 3/20 (20130101) G01N 17/02 (20130101) G01N 17/04 (20130101) Original (OR) Class G01N 17/043 (20130101) G01N 19/04 (20130101) G01N 27/20 (20130101) G01N 27/22 (20130101) G01N 27/023 (20130101) G01N 27/041 (20130101) G01N 33/0031 (20130101) G01N 2203/024 (20130101)
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10768142 — Nanochannel arrays and their preparation and use for high throughput macromolecular analysis

US 10768142	Austin et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Robert H. Austin (Princeton, New Jersey); Zhaoning Yu (Palo Alto, California); Jonas O. Tegenfeldt (Lund, Sweden); Stephen Y. Chou (Princeton, New Jersey); Han Cao (San Diego, California)
ABSTRACT	Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.
FILED	Thursday, March 28, 2019
APPL NO	16/367701
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2219/00274 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 2200/12 (20130101) B01L 2200/0663 (20130101) B01L 2300/0627 (20130101) B01L 2300/0861 (20130101) B01L 2300/0896 (20130101) B01L 2400/086 (20130101) B01L 2400/0415 (20130101) B01L 2400/0418 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 1/002 (20130101) B81B 2201/058 (20130101) B81B 2203/0338 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00071 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/648 (20130101) G01N 21/6428 (20130101) G01N 27/447 (20130101) G01N 27/44791 (20130101) Original (OR) Class G01N 33/48721 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/88 (20130101) Y10S 977/704 (20130101) Y10S 977/883 (20130101)
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10768165 — Systems and methods for measuring water and lipid content in tissue samples

US 10768165	Roblyer et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
ASSIGNEE(S)	TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
INVENTOR(S)	Darren Roblyer (Jamaica Plain, Massachusetts); Yanyu Zhao (Pasadena, California)
ABSTRACT	An imaging system for measuring water and blood lipid content in a tissue sample includes a light source configured to emit a plurality of sequential wavelengths of light within a predetermined range of wavelengths, a spatial modulation device configured to direct each of the plurality of sequential wavelengths of light onto a tissue sample plane to generate a first plurality of patterns on the issue sample plane at a first spatial frequency and a second plurality of patterns on the tissue sample plane at a second spatial frequency, an imaging device configured to generate first image data reproducible as images the first plurality of patterns and second image data reproducible as images the second plurality of patterns, and a controller configured to determine a first optical property and a second optical property for each location on the sample plane.
FILED	Friday, April 05, 2019
APPL NO	16/376561
ART UNIT	2884 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/27 (20130101) G01N 21/49 (20130101) G01N 21/359 (20130101) G01N 21/3554 (20130101) G01N 21/4738 (20130101) G01N 33/4833 (20130101) Original (OR) Class G01N 2021/1757 (20130101) G01N 2021/1765 (20130101) G01N 2201/12 (20130101) G01N 2201/0675 (20130101)
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10768299 — Vessel-towed multiple sensor systems and related methods

US 10768299	Lanham et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Surface Warfare Center (NSWC)
APPLICANT(S)	The United States of America, as represented by the Secretary of the Navy (Crane, Indiana)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Robert S Lanham (Bedford, Indiana); William Stocke (Bloomington, Indiana)
ABSTRACT	An embodiment can include a vessel-towed system that includes a first towing/communication interface system, e.g., a first tow cable with a fiber optic system, and spaced apart buoys for supporting the first tow cable. A first mobile structure including a first control system and first type of emitter, e.g., an attraction system, is connected to the first tow cable. A second mobile structure is provided that can include an underwater towed emitter such as an audio emulation system. The first and second emitters can be configured emit a first and second plurality of emissions for inducing a receiving entity response. The second mobile structure is coupled with the first mobile structure with a second tow cable that comprises another fiber optic cable. An automated response or manual control systems can be provided on the towing vessel and the first mobile structure adapted to operate the first and second emitters.
FILED	Tuesday, April 03, 2018
APPL NO	15/944756
ART UNIT	3669 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/66 (20130101) B63B 22/00 (20130101) B63B 43/18 (20130101) Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 11/48 (20130101) Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/38 (20130101) B63G 8/42 (20130101) Marine Propulsion or Steering B63H 25/04 (20130101) B63H 25/38 (20130101) B63H 2025/045 (20130101) Targets; Target Ranges; Bullet Catchers F41J 9/06 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/02 (20130101) G01S 7/003 (20130101) G01S 13/862 (20130101) G01S 15/86 (20200101) Original (OR) Class G01S 15/88 (20130101) G01S 15/8902 (20130101)
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10768320 — Field deployable neutron/gamma spectrometer

US 10768320	Bloser et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA)
APPLICANT(S)	University of New Hampshire (Durham, New Hampshire)
ASSIGNEE(S)
INVENTOR(S)	Peter F. Bloser (Portsmouth, New Hampshire); Jason Legere (Sandford, Maine); Christopher M. Bancroft (Sanbornville, New Hampshire)
ABSTRACT	A system of the present disclosure is capable of detecting, imaging and measuring both neutrons and gamma rays. The system may be portable and/or field deployable. The system may include two or more detector layer cases and a digital processing unit case. The system has a plurality of parallel plates each containing a plurality of detectors. The plates may have non-PSD organic scintillation detectors, scintillation detectors having pulse-shape discrimination (PSD) properties, and inorganic scintillation detectors. A first plate and a second plate are housed within detector layer cases. The scintillation detectors are used in connection to detect, image and measure neutrons and/or gamma rays.
FILED	Friday, May 11, 2018
APPL NO	15/977616
ART UNIT	2884 — Optics
CURRENT CPC	Measurement of Nuclear or X-radiation G01T 1/29 (20130101) G01T 1/2008 (20130101) G01T 3/06 (20130101) Original (OR) Class
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10768368 — Waveguide formation using CMOS fabrication techniques

US 10768368	Orcutt et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Jason Scott Orcutt (Katonah, New York); Karan Kartik Mehta (Cambridge, Massachusetts); Rajeev Jagga Ram (Arlington, Massachusetts); Amir Hossein Atabaki (Brookline, Massachusetts)
ABSTRACT	Conventional approaches to integrating waveguides within standard electronic processes typically involve using a dielectric layer, such as polysilicon, single-crystalline silicon, or silicon nitride, within the in-foundry process or depositing and patterning a dielectric layer in the backend as a post-foundry process. In the present approach, the back-end of the silicon handle is etched away after in-foundry processing to expose voids or trenches defined using standard in-foundry processing (e.g., complementary metal-oxide-semiconductor (CMOS) processing). Depositing dielectric material into a void or trench yields an optical waveguide integrated within the front-end of the wafer. For example, a shallow trench isolation (STI) layer formed in-foundry may serve as a high-resolution patterning waveguide template in a damascene process within the front end of a die or wafer. Filling the trench with a high-index dielectric material yields a waveguide that can guide visible and/or infrared light, depending on the waveguide's dimensions and refractive index contrast.
FILED	Tuesday, November 12, 2019
APPL NO	16/680630
ART UNIT	2874 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/122 (20130101) G02B 6/132 (20130101) G02B 6/136 (20130101) Original (OR) Class G02B 6/305 (20130101) G02B 6/1225 (20130101) G02B 6/12004 (20130101) G02B 2006/121 (20130101) G02B 2006/12061 (20130101) G02B 2006/12097 (20130101) G02B 2006/12107 (20130101) G02B 2006/12123 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/025 (20130101) G02F 1/0147 (20130101) G02F 2001/0151 (20130101)
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10768659 — Apparatus and methods for optical neural network

US 10768659	Carolan et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Jacques Johannes Carolan (Somerville, Massachusetts); Mihika Prabhu (Cambridge, Massachusetts); Scott A. Skirlo (Boston, Massachusetts); Yichen Shen (Cambridge, Massachusetts); Marin Soljacic (Belmont, Massachusetts); Nicholas Christopher Harris (Cambridge, Massachusetts); Dirk Englund (Brookline, Massachusetts)
ABSTRACT	An optical neural network is constructed based on photonic integrated circuits to perform neuromorphic computing. In the optical neural network, matrix multiplication is implemented using one or more optical interference units, which can apply an arbitrary weighting matrix multiplication to an array of input optical signals. Nonlinear activation is realized by an optical nonlinearity unit, which can be based on nonlinear optical effects, such as saturable absorption. These calculations are implemented optically, thereby resulting in high calculation speeds and low power consumption in the optical neural network.
FILED	Tuesday, February 12, 2019
APPL NO	16/273257
ART UNIT	2883 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/225 (20130101) G02F 1/365 (20130101) G02F 1/3526 (20130101) G02F 3/024 (20130101) G02F 2001/212 (20130101) G02F 2202/32 (20130101) G02F 2203/15 (20130101) Optical Computing Devices; G06E 3/005 (20130101) Original (OR) Class G06E 3/006 (20130101) G06E 3/008 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/084 (20130101) G06N 3/0675 (20130101)
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10768769 — Automatic event detection, text generation, and use thereof

US 10768769	Choe et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	AVIGILON FORTRESS CORPORATION (Vancouver, Canada)
ASSIGNEE(S)	AVIGILON FORTRESS CORPORATION (Vancouver, British Columbia, Canada)
INVENTOR(S)	Tae Eun Choe (Reston, Virginia); Mun Wai Lee (Ashburn, Virginia); Kiran Gunda (Vienna, Virginia); Niels Haering (Reston, Virginia)
ABSTRACT	A system and method for video surveillance and searching are disclosed. Video is analyzed and events are automatically detected. Based on the automatically detected events, textual descriptions are generated. The textual descriptions may be used to supplement video viewing and event viewing, and to provide for textual searching for events.
FILED	Thursday, February 23, 2017
APPL NO	15/440945
ART UNIT	2616 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC	Card, Board, or Roulette Games; Indoor Games Using Small Moving Playing Bodies; Video Games; Games Not Otherwise Provided for A63F 13/48 (20140902) A63F 13/60 (20140902) A63F 13/352 (20140902) A63F 13/795 (20140902) Electric Digital Data Processing G06F 3/048 (20130101) Original (OR) Class G06F 3/04815 (20130101) G06F 16/78 (20190101) G06F 16/738 (20190101) G06F 16/784 (20190101) G06F 16/7837 (20190101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 13/19665 (20130101) Pictorial Communication, e.g Television H04N 5/2621 (20130101)
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10769076 — Distributed address translation in a multi-node interconnect fabric

US 10769076	Duncan et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	NVIDIA Corporation (Santa Clara, California)
ASSIGNEE(S)	NVIDIA Corporation (Santa Clara, California)
INVENTOR(S)	Samuel Hammond Duncan (Franklin, Massachusetts); Sanjeev Jain (Chandler, Arizona); Mark Douglas Hummel (Franklin, Massachusetts); Vyas Venkataraman (Sharon, Massachusetts); Olivier Giroux (Santa Clara, California); Larry Robert Dennison (Mendon, Massachusetts); Alexander Toichi Ishii (Lebanon, New Hampshire); Hemayet Hossain (San Jose, California); Nir Haim Arad (Snoqualmie, Washington)
ABSTRACT	Multiprocessor clusters in a virtualized environment conventionally fail to provide memory access security, which is frequently a requirement for efficient utilization in multi-client settings. Without adequate access security, a malicious process may access what might be confidential data that belongs to a different client sharing the multiprocessor cluster. Furthermore, an inadvertent programming error in the code for one client process may accidentally corrupt data that belongs to the different client. Neither scenario is acceptable. Embodiments of the present disclosure provide access security by enabling each processing node within a multiprocessor cluster to virtualize and manage local memory access and only process access requests possessing proper access credentials. In this way, different applications executing on a multiprocessor cluster may be isolated from each other while advantageously sharing the hardware resources of the multiprocessor cluster.
FILED	Wednesday, November 21, 2018
APPL NO	16/198649
ART UNIT	2137 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 12/1027 (20130101) Original (OR) Class G06F 2212/68 (20130101) G06F 2212/1044 (20130101)
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10769259 — Behavioral biometric feature extraction and verification

US 10769259	Baldwin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Assured Information Security, Inc. (Rome, New York)
ASSIGNEE(S)	ASSURED INFORMATION SECURITY, INC. (Rome, Italy)
INVENTOR(S)	Jacob Baldwin (Cleveland, New York); Ryan Burnham (Fairport, New York); Robert Dora (Sherrill, New York); Andrew Meyer (Brockport, New York); Robert Wright (Sherrill, New York)
ABSTRACT	A method for keystroke-based behavioral verification of user identity of a subject user of a computer system includes obtaining an enrollment signature corresponding to an identified user and serving as a unique identifier of the identified user, the enrollment signature including an enrollment determinate vector generated based on supplying enrollment keystroke data to a deep neural network for processing. The method further includes obtaining verification determinate vector(s), the verification determinate vector(s) for comparison to the enrollment signature to determine whether the subject user is the identified user. The method compares the verification determinate vector(s) to the enrollment signature and generates a probability indicator indicating a probability that keystroke data from a common user produced, from the deep neural network, the enrollment signature and the verification determinate vector(s), and indicates to the computer system whether, based on the probability indicator, the subject user is verified to be the identified user.
FILED	Tuesday, April 10, 2018
APPL NO	15/949723
ART UNIT	2493 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class G06F 2221/2151 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101)
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10769260 — Behavioral biometric feature extraction and verification

US 10769260	Baldwin et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Assured Information Security, Inc. (Rome, New York)
ASSIGNEE(S)	ASSURED INFORMATION SECURITY, INC. (Rome, New York)
INVENTOR(S)	Jacob Baldwin (Cleveland, New York); Ryan Burnham (Fairport, New York); Robert Dora (Sherrill, New York); Andrew Meyer (Brockport, New York); Robert Wright (Sherrill, New York)
ABSTRACT	A method for gait-based behavioral verification of user identity of a subject user of a computer system includes obtaining an enrollment signature corresponding to an identified user and serving as a unique identifier of the identified user, the enrollment signature including an enrollment determinate vector generated based on supplying enrollment gait data to a deep neural network for processing. The method further includes obtaining verification determinate vector(s), the verification determinate vector(s) for comparison to the enrollment signature to determine whether the subject user is the identified user. The method compares the verification determinate vector(s) to the enrollment signature and generates a probability indicator indicating a probability that gait data from a common user produced, from the deep neural network, the enrollment signature and the verification determinate vector(s), and indicates to the computer system whether, based on the probability indicator, the subject user is verified to be the identified user.
FILED	Tuesday, April 10, 2018
APPL NO	15/949738
ART UNIT	2492 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class G06F 2221/2151 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0472 (20130101)
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10769491 — Machine learning system for generating classification data and part localization data for objects depicted in images

US 10769491	Matei et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Navy Engineering Logistics Office (NELO)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)	SRI International (Menlo Park, California)
INVENTOR(S)	Bogdan Calin Mihai Matei (Princeton Junction, New Jersey); Xiyang Dai (Edison, New Jersey); John Benjamin Southall (Philadelphia, Pennsylvania); Nhon Hoc Trinh (Plainsboro, New Jersey); Harpreet Sawhney (West Windsor, New Jersey)
ABSTRACT	Techniques are disclosed for identifying discriminative, fine-grained features of an object in an image. In one example, an input device receives an image. A machine learning system includes a model comprising a first set, a second set, and a third set of filters. The machine learning system applies the first set of filters to the received image to generate an intermediate representation of the received image. The machine learning system applies the second set of filters to the intermediate representation to generate part localization data identifying sub-parts of an object and one or more regions of the image in which the sub-parts are located. The machine learning system applies the third set of filters to the intermediate representation to generate classification data identifying a subordinate category to which the object belongs. The system uses the part localization and classification data to perform fine-grained classification of the object.
FILED	Friday, August 31, 2018
APPL NO	16/120023
ART UNIT	2641 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00362 (20130101) G06K 9/623 (20130101) Original (OR) Class G06K 9/627 (20130101) G06K 9/00664 (20130101) G06K 9/4628 (20130101) G06K 9/6271 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0454 (20130101) G06N 20/00 (20190101)
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10769519 — Converting digital numeric data to spike event data

US 10769519	Alvarez-Icaza Rivera et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Rodrigo Alvarez-Icaza Rivera (Mountain View, California); John V. Arthur (Mountain View, California); Andrew S. Cassidy (San Jose, California); Steven K. Esser (San Jose, California); Myron D. Flickner (San Jose, California); Bryan L. Jackson (Fremont, California); Paul A. Merolla (Palo Alto, California); Dharmendra S. Modha (San Jose, California); Jun Sawada (Austin, Texas); Benjamin G. Shaw (San Francisco, California)
ABSTRACT	One embodiment of the invention provides a system comprising at least one data-to-spike converter unit for converting input numeric data received by the system to spike event data. Each data-to-spike converter unit is configured to support one or more spike codes.
FILED	Tuesday, November 14, 2017
APPL NO	15/812589
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/06 (20130101) Original (OR) Class
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10769539 — Automatic evaluation of a knowledge canvassing application

US 10769539	Beller et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Charles E. Beller (Baltimore, Maryland); Kristen M. Summers (Takoma Park, Maryland)
ABSTRACT	A system includes a knowledge canvassing system executed by a computer, a processor, and a memory coupled to the processor. The memory is encoded with instructions that when executed cause the processor to provide a training system configured to generate benchmark data, each benchmark datum including a set of one or more benchmark input entities and a set of one or more benchmark output entities associated with the one or more benchmark input entities, query the knowledge canvassing system with each set of benchmark input entities, receive, for each set of benchmark input entities queried, an output result from the knowledge canvassing system that includes a set of zero or more knowledge canvassing system output entities, and generate an evaluation score for each set of knowledge canvassing system output entities based on a comparison of the knowledge canvassing system output entities with the set of benchmark output entities.
FILED	Tuesday, August 16, 2016
APPL NO	15/238172
ART UNIT	2124 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 16/9024 (20190101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Original (OR) Class G06N 5/022 (20130101)
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10769783 — Predicting prostate cancer biochemical recurrence using combined nuclear NF-KB/P65 localization and gland morphology

US 10769783	Madabhushi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Anant Madabhushi (Shaker Heights, Ohio); Patrick Leo (Honoeye Falls, New York); Andrew Janowczyk (East Meadow, New York); Sanjay Gupta (Mayfield Heights, Ohio)
ABSTRACT	Embodiments include controlling a processor to perform operations for predicting biochemical recurrence (BCR) in prostate cancer (PCa), including accessing a first digitized pathology slide having a first stain channel of a region of tissue demonstrating PCa; accessing a second digitized pathology slide having a second, different stain channel of the region of tissue; extracting morphology features from the first stain channel; extracting stain intensity features from the second stain channel, where a stain intensity feature quantifies an amount of a molecular biomarker present in a cellular nucleus; controlling a first machine learning classifier to generate a first probability of BCR based on the morphology features; controlling a second machine learning classifier to generate a second, different probability of BCR based on the stain intensity features; computing an aggregate probability of BCR based on the first probability and the second probability; and displaying the aggregate probability.
FILED	Wednesday, December 12, 2018
APPL NO	16/217274
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/6202 (20130101) G06K 9/6223 (20130101) G06K 9/6277 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20036 (20130101) G06T 2207/20081 (20130101) G06T 2207/30024 (20130101)
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10770206 — System and method for fabricating a strain sensing device directly on a structure

US 10770206	Aga et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S)	Roberto S. Aga (Beavercreek, Ohio); Emily M. Heckman (Dayton, Ohio)
ABSTRACT	Various deficiencies in the prior art are addressed by systems, methods, architectures, mechanisms and/or apparatus configured for fabricating a strain sensing device directly on a structure by printing a material on the structure, the material exhibiting a piezo-resistive effect, and sintering a strain sensing pattern from the material such that the strain sensing pattern becomes electrically conductive.
FILED	Monday, April 08, 2019
APPL NO	16/377302
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/18 (20130101) Resistors H01C 10/10 (20130101) H01C 17/065 (20130101) Original (OR) Class
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10770670 — Inverted organic photosensitive devices

US 10770670	Forrest et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Energy (DOE)
APPLICANT(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Stephen R. Forrest (Ann Arbor, Michigan); Rhonda F. Bailey-Salzman (San Ramon, California)
ABSTRACT	The present disclosure relates to organic photosensitive optoelectronic devices grown in an inverted manner. An inverted organic photosensitive optoelectronic device of the present disclosure comprises a reflective electrode, an organic donor-acceptor heterojunction over the reflective electrode, and a transparent electrode on top of the donor-acceptor heterojunction.
FILED	Monday, October 24, 2016
APPL NO	15/332062
ART UNIT	2814 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/228 (20130101) H01L 21/2225 (20130101) H01L 27/302 (20130101) H01L 51/0053 (20130101) H01L 51/0072 (20130101) H01L 51/0078 (20130101) H01L 51/424 (20130101) H01L 51/441 (20130101) H01L 51/442 (20130101) H01L 51/4246 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101)
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10770742 — Electrical power distribution system and method for a grid-tied reversible solid oxide fuel cell system

US 10770742	Mermelstein et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	THE BOEING COMPANY (Chicago, Illinois)
INVENTOR(S)	Joshua M. Mermelstein (Laguna Niguel, California); Sergio Espinoza (Huntington Beach, California)
ABSTRACT	A Reversible Solid Oxide Fuel Cell (RSOFC) system includes a Reversible Solid Oxide Fuel Cell (RSOFC) unit, a bi-directional alternating current/direct current (AC/DC) converter, coupled to the RSOFC unit, a common bus, coupled to the bi-directional AC/DC converter and to a power grid, and a plurality of RSOFC subsystems, coupled to receive power only through the common bus. The RSOFC unit has a fuel cell mode, wherein the RSOFC unit produces electrical power from fuel, and an electrolysis mode, wherein the RSOFC unit consumes electrical power to produce the fuel. The bi-directional AC/DC converter is coupled to the RSOFC unit, and is configured to convert direct current (DC) electrical power produced by the RSOFC unit into outgoing alternating current (AC) power, and to convert incoming AC power into DC power for consumption by the RSOFC unit in electrolysis mode.
FILED	Tuesday, February 20, 2018
APPL NO	15/900223
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/186 (20130101) Original (OR) Class H01M 8/0494 (20130101) H01M 8/04604 (20130101) H01M 8/04671 (20130101) H01M 8/04679 (20130101) H01M 2008/1293 (20130101) H01M 2250/10 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/387 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 90/14 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/525 (20130101) Y02E 60/528 (20130101)
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10770859 — Short pulse wavelength tuning via timed soliton-dispersive wave interaction

US 10770859	Langseth et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Jason E. Langseth (Malden, Massachusetts); Darren A. Rand (Cambridge, Massachusetts)
ABSTRACT	When a soliton and a dispersive pulse propagate in an optical fiber, they can interact via cross-phase modulation, which occurs when one pulse modulates the refractive index experienced by the other pulse. Cross-phase modulation causes each pulse to shift in wavelength by an amount proportional to the time delay between the pulses. Changing the time delay between the pulses changes the wavelength shift of each pulse. This make it possible to produce pulses whose output wavelengths can be tuned over large ranges, e.g. hundreds of nm, in a time as short as the pulse repetition period of the laser (e.g., at rates of megahertz or gigahertz). Such a laser requires no moving parts, providing high reliability. The laser's optical path can be made entirely of optical fiber, providing high efficiency with low size, weight, and power consumption.
FILED	Thursday, May 24, 2018
APPL NO	15/988058
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/35 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) H01S 3/0085 (20130101) H01S 3/0092 (20130101) H01S 3/0809 (20130101) H01S 3/1106 (20130101) H01S 3/2391 (20130101) H01S 3/06725 (20130101) Original (OR) Class
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10770861 — Light-emitting device having self-cooled semiconductor laser

US 10770861	Osinski et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S)	UNM Rainforest Innovations (Albuquerque, New Mexico)
INVENTOR(S)	Marek Osinski (Albuquerque, New Mexico); Gennady A. Smolyakov (Albuquerque, New Mexico)
ABSTRACT	A light-emitting device having a self-cooled semiconductor laser having a laser cavity.
FILED	Wednesday, May 15, 2019
APPL NO	16/413570
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/026 (20130101) H01S 5/34 (20130101) H01S 5/101 (20130101) H01S 5/125 (20130101) H01S 5/02461 (20130101) Original (OR) Class
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10771159 — Fiber optic patch and voltage conditioning

US 10771159	Nguyen
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Systems Command (NAVAIR) Naval Air Warfare Center Aircraft Division (NAWCAD) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	iSenseCloud, Inc. (San Jose, California)
ASSIGNEE(S)	iSenseClound, Inc. (San Jose, California)
INVENTOR(S)	An-Dien Nguyen (Fremont, California)
ABSTRACT	Apparatuses relate generally to a fiber optic cable. In such an apparatus, a housing has a channel or bore for receipt of a portion of the fiber optic cable having a fiber optic sensor. An acoustic interface layer is coupled to a surface of the housing to reduce stress wave coupling loss at an interface between the fiber optic sensor and a host structure surface. In another such apparatus, a patch structure is for a fiber optic cable coupled to a fiber optic voltage conditioner. In yet another such apparatus, a fiber optic voltage conditioner is coupled for optical communication to a fiber optic cable having a Fiber Bragg Grating sensor. The fiber optic voltage conditioner includes a tunable light source having a broadband light source or a gain medium configured to provide a narrowband light signal from a broadband light signal for providing to the fiber optic cable.
FILED	Monday, July 16, 2018
APPL NO	16/036146
ART UNIT	2853 — Printing/Measuring and Testing
CURRENT CPC	Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/22 (20130101) G01K 11/3206 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/246 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 5/0033 (20130101) G01M 11/085 (20130101) Optical Elements, Systems, or Apparatus G02B 6/02114 (20130101) G02B 6/02171 (20130101) G02B 6/02209 (20130101) G02B 6/2938 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/12 (20130101) H01S 5/062 (20130101) H01S 5/0078 (20130101) H01S 5/0617 (20130101) H01S 5/0687 (20130101) H01S 5/02415 (20130101) H01S 5/4025 (20130101) H01S 5/4087 (20130101) H01S 5/06804 (20130101) H01S 5/06808 (20130101) Transmission H04B 10/25 (20130101) Original (OR) Class
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10771176 — Method for combating impulsive interference/noise in multicarrier underwater acoustic communications

US 10771176	Liu
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Zhiqiang Liu (Henrico, Virginia)
ABSTRACT	A communication system includes a repetitive orthogonal frequency-division multiplexing (“ROFDM”) transmitter communicating with an ROFDM receiver. The ROFDM transmitter includes an ROFDM modulator, which includes a K-point Fast Fourier Transform receiving a block of time-domain data symbols and generating an initial orthogonal frequency-division multiplexing symbol. The initial orthogonal frequency-division multiplexing symbol is based on a block of frequency-domain data symbols corresponding to the block of time-domain data symbols. The initial orthogonal frequency-division multiplexing symbol includes an ending part. The ROFDM modulator includes an orthogonal frequency-division multiplexing symbol repeater generating a repetitive orthogonal frequency-division multiplexing symbol by repeatedly reproducing the initial orthogonal frequency-division multiplexing symbol. The modulator includes a cyclic prefix adder prepending a cyclic prefix to the repetitive orthogonal frequency-division multiplexing symbol to generate a baseband transmitted signal. The cyclic prefix includes the ending part of the initial orthogonal frequency-division multiplexing symbol. The ROFDM receiver includes an ROFDM demodulator.
FILED	Tuesday, January 15, 2019
APPL NO	16/247626
ART UNIT	2468 — Multiplex and VoIP
CURRENT CPC	Transmission H04B 11/00 (20130101) Multiplex Communication H04J 1/05 (20130101) Original (OR) Class H04J 11/003 (20130101) H04J 2011/0009 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/2602 (20130101) H04L 27/2666 (20130101)
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10771404 — Performance monitoring

US 10771404	Keppel et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)	Intel Corporation (Santa Clara, California)
INVENTOR(S)	David Keppel (Mountain View, California); Thomas D. Lovett (Portland, Oregon); Michael A. Parker (Santa Clara, California); Robert C. Zak, Jr. (Bolton, Massachusetts)
ABSTRACT	Particular embodiments described herein provide for a network element that can be configured to receive a request message, wherein the request message includes a read trigger, an indicator selector, and a completion trigger, determine an indicator that relates to the indicator selector, and perform an action when the read trigger is activated.
FILED	Thursday, December 22, 2016
APPL NO	15/388604
ART UNIT	2441 — Computer Networks
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 43/08 (20130101) H04L 43/10 (20130101) H04L 43/16 (20130101) H04L 43/022 (20130101) H04L 49/901 (20130101) Original (OR) Class
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10771722 — Methods for enabling in-field selection of near-sensor digital imaging functions

US 10771722	Grossmann et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Peter J. Grossmann (Somerville, Massachusetts); Matthew Stamplis (Boston, Massachusetts); Kate Thurmer (Somerville, Massachusetts); Brian Tyrrell (Brookline, New Hampshire); Jonathan Frechette (Marlborough, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Peter J. Grossmann (Somerville, Massachusetts); Matthew Stamplis (Boston, Massachusetts); Kate Thurmer (Somerville, Massachusetts); Brian Tyrrell (Brookline, New Hampshire); Jonathan Frechette (Marlborough, Massachusetts)
ABSTRACT	An imaging device is often paired with a readout integrated circuit (ROIC), which provides processing and data transfer functionality. The circuitry of a ROIC is typically specialized to meet the requirements of an application, which limits the ROIC to a few modes of operation and restricts compatibility to only certain types of imaging devices and applications. Furthermore, the circuitry supporting the processing functionality is limited due to size constraints on the ROIC. These shortcomings can be overcome with a field programmable imaging array (FPIA), which can be implemented as an integrated circuit combining customized ROIC sensor interface circuitry with field programmable gate array (FPGA) circuitry to enable post-fabrication definition of ROIC operational modes. An FPIA chip may form part of a three-chip stack that also includes an analog sensor interface chip for analog-to-digital conversion and an imaging device.
FILED	Friday, September 28, 2018
APPL NO	16/145272
ART UNIT	2697 — Selective Visual Display Systems
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14634 (20130101) H01L 27/14649 (20130101) Pulse Technique H03K 19/17744 (20130101) Coding; Decoding; Code Conversion in General H03M 9/00 (20130101) Pictorial Communication, e.g Television H04N 5/374 (20130101) H04N 5/378 (20130101) Original (OR) Class H04N 5/379 (20180801) H04N 5/3765 (20130101)
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10771903 — Electrostatic graphene speaker

US 10771903	Zhou et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Qin Zhou (Fremont, California); Alexander K. Zettl (Kensington, California)
ABSTRACT	This disclosure provides systems, methods, and apparatus associated with an electrostatically driven graphene speaker. In one aspect, a device includes a graphene membrane, a first frame on a first side of the graphene membrane, and a second frame on a second side of the graphene membrane. The first frame and the second frame both include substantially circular open regions that define a substantially circular portion of the graphene membrane. A first electrode is proximate the first side of the circular portion of the graphene membrane. A second electrode proximate the second side of the circular portion of the graphene membrane.
FILED	Friday, February 07, 2020
APPL NO	16/785089
ART UNIT	2651 — Videophones and Telephonic Communications
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/02 (20130101) H04R 19/005 (20130101) Original (OR) Class H04R 23/002 (20130101) H04R 29/001 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/733 (20130101)
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Department of Energy (DOE)

10765775 — Implantable medical devices comprising bio-degradable alloys with enhanced degradation rates

US 10765775	Radisch et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Bio DG, Inc. (Poway, California); U.S. Department of Energy (Washington, District of Columbia)
ASSIGNEE(S)	Bio DG, Inc. (Poway, California); U.S. Department of Energy (Washington, District of Columbia)
INVENTOR(S)	Herbert Radisch (San Diego, California); Paul Jablonski (Poway, California)
ABSTRACT	The invention provides medical devices comprising high-strength alloys which degrade over time in the body of a human or animal, at controlled degradation rates, without generating emboli and which have enhanced degradation due to the presence of a halogen component. In one embodiment the alloy is formed into a bone fixation device such as an anchor, screw, plate, support or rod. In another embodiment the alloy is formed into a tissue fastening device such as staple. In yet another embodiment, the alloy is formed into a dental implant or a stent.
FILED	Wednesday, January 23, 2019
APPL NO	16/255093
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 8/0012 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/042 (20130101) Original (OR) Class A61L 31/16 (20130101) A61L 31/022 (20130101) A61L 31/148 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/12292 (20150115)
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10765864 — Retinal-inspired method and system for improved detection

US 10765864	Chance et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Frances S. Chance (Albuquerque, New Mexico); Christina E. Warrender (New Ipswich, New Hampshire)
ABSTRACT	The present disclosure provides a method and device for filtering sensor data. Signals from an array of sensor pixels are received and checked for changes in pixel values. Motion is detected based on the changes in pixel values, and motion output signals are transmitted to a processing station. If the sum of correlated changes in pixel values across a predetermined field of view exceeds a predetermined value, indicating sensor jitter, the motion output signals are suppressed. If a sum of motion values within a defined subsection of the field of view exceeds a predetermined threshold, indicating the presence of a large object of no interest, the motion output signals are suppressed for that subsection.
FILED	Thursday, August 09, 2018
APPL NO	16/059746
ART UNIT	2647 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/14 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36046 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/605 (20130101) Computer Systems Based on Specific Computational Models G06N 3/049 (20130101)
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10765997 — Regenerable non-aqueous basic immobilized amine slurries for removal of CO₂from a gaseous mixture and a method of use thereof

US 10765997	Shi et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	Energy, United States Department of (Washington, District of Columbia)
ASSIGNEE(S)	U.S. Department of Energy (Washington, District of Columbia)
INVENTOR(S)	Fan Shi (Pittsburgh, Pennsylvania); McMahan L. Gray (Pittsburgh, Pennsylvania); Jeffrey Culp (Wexford, Pennsylvania); Brian W. Kail (Pittsburgh, Pennsylvania); Christopher Mark Marin (South Park, Pennsylvania)
ABSTRACT	The disclosure provides a composition for the separation of CO₂from a gaseous mixture and a method of use thereof. The composition comprises solid Basic Immobilized Amine Sorbents (BIAS) suspended in silicone oil. The method of use comprises contacting the gaseous mixture with a sorbent slurry comprising Basic Immobilized Amine Sorbents (BIAS) and silicone oil to at least partially absorb the CO₂from the gaseous mixture, and regenerating the BIAS slurry by causing desorption of the CO₂.
FILED	Thursday, August 23, 2018
APPL NO	16/110352
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Separation B01D 53/62 (20130101) B01D 53/80 (20130101) Original (OR) Class B01D 53/96 (20130101) B01D 2252/204 (20130101) B01D 2257/504 (20130101) B01D 2258/0283 (20130101)
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10766005 — Nanostructured polyelectrolytes for ion-selective membranes

US 10766005	Small et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Leo J. Small (Albuquerque, New Mexico); Stephen Percival (Albuquerque, New Mexico); Erik David Spoerke (Albuquerque, New Mexico)
ABSTRACT	Nanostructured polyelectrolyte bilayers deposited by Layer-by-Layer deposition on nanoporous membranes can be selectively crosslinked to modify the polyelectrolyte charge density and control ionic selectivity independent of ionic conductivity. For example, the polyelectrolyte bilayer can comprise a cationic polymer layer, such as poly(ethyleneimine), and an anionic polymer layer, such as poly(acrylic acid). Increasing the number of bilayers increases the cation selectivity when the poly(ethyleneimine) layer is crosslinked with glutaraldehyde. Crosslinking the membranes also increases the chemical and mechanical strength of the polyelectrolyte films. This controllable and inexpensive method can be used to create ion-selective and mechanically robust membranes on porous supports for a wide range of applications.
FILED	Tuesday, September 11, 2018
APPL NO	16/128081
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Separation B01D 61/46 (20130101) B01D 61/445 (20130101) Original (OR) Class B01D 69/02 (20130101) B01D 69/125 (20130101) B01D 71/40 (20130101) B01D 71/60 (20130101) B01D 2325/14 (20130101) B01D 2325/16 (20130101) B01D 2325/42 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 43/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/245 (20130101) C08J 5/2287 (20130101) C08J 2333/02 (20130101) C08J 2379/02 (20130101)
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10766181 — Magnetic feed material and its use in producing bonded permanent magnets by additive manufacturing

US 10766181	Paranthaman et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee); Magnet Applications Inc. (DuBois, Pennsylvania)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Mariappan Parans Paranthaman (Knoxville, Tennessee); Ling Li (Austin, Texas); Vlastimil Kunc (Knoxville, Tennessee); Brian K. Post (Knoxville, Tennessee); Orlando Rios (Knoxville, Tennessee); Robert H. Fredette (DuBois, Pennsylvania); John Ormerod (Loudon, Tennessee)
ABSTRACT	A method for producing magnet-polymer pellets useful as a feedstock in an additive manufacturing process, comprising: (i) blending thermoplastic polymer and hard magnetic particles; (ii) feeding the blended magnet-polymer mixture into a pre-feed hopper that feeds directly into an inlet of a temperature-controlled barrel extruder; (iii) feeding the blended magnet-polymer mixture into the barrel extruder at a fixed feed rate of 5-20 kg/hour, wherein the temperature at the outlet is at least to no more than 10° C. above a glass transition temperature of the blended magnet-polymer mixture; (iv) feeding the blended magnet-polymer mixture directly into an extruding die; (v) passing the blended magnet-polymer mixture through the extruding die at a fixed speed; and (vi) cutting the magnet-polymer mixture at regular intervals as the mixture exits the extruding die at the fixed speed. The use of the pellets as feed material in an additive manufacturing process is also described.
FILED	Friday, October 27, 2017
APPL NO	15/796110
ART UNIT	1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/04 (20190201) B29C 48/0022 (20190201) B29C 48/022 (20190201) Original (OR) Class B29C 48/83 (20190201) B29C 48/92 (20190201) B29C 48/875 (20190201) B29C 64/106 (20170801) B29C 64/314 (20170801) B29C 2948/92209 (20190201) B29C 2948/92704 (20190201) B29C 2948/92895 (20190201) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2077/00 (20130101) B29K 2103/06 (20130101) B29K 2505/12 (20130101) B29K 2995/0008 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/08 (20130101) C08K 2003/0856 (20130101) C08K 2201/01 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/0572 (20130101) H01F 1/0578 (20130101) H01F 41/0253 (20130101)
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10766640 — Payload interposer (PIP) system and control software

US 10766640	Proicou et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Michael Proicou (Los Alamos, New Mexico); Adam Warniment (Los Alamos, New Mexico); Paul Stein (Los Alamos, New Mexico); Nicholas Dallmann (Los Alamos, New Mexico); Daniel Seitz (Los Alamos, New Mexico); Logan Ott (Los Alamos, New Mexico)
ABSTRACT	A payload interposer (PIP) system and its control software provide an interface between a space vehicle and a payload. The PIP board facilitates power and communications between a command and data handler (CDH) of the space vehicle and the payload. A microcontroller of the PIP board may control operation of the payload, format messages between the space vehicle and the payload, and extract data from the payload for downlink via the space vehicle.
FILED	Thursday, March 29, 2018
APPL NO	15/940816
ART UNIT	3668 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/428 (20130101) B64G 1/641 (20130101) Original (OR) Class
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10766831 — Stability of gas atomized reactive powders through multiple step in-situ passivation

US 10766831	Anderson et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Ames Laboratory (AL) Federally Funded Research and Development Center (FFRDC) Operated by Iowa State University (IASTATE) at Ames, IA
APPLICANT(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
INVENTOR(S)	Iver E. Anderson (Ames, Iowa); Andrew D. Steinmetz (Peoria, Illinois); David J. Byrd (Boone, Iowa)
ABSTRACT	A method for gas atomization of oxygen-reactive reactive metals and alloys wherein the atomized particles are exposed as they solidify and cool in a very short time to multiple gaseous reactive agents for the in-situ formation of a protective reaction film on the atomized particles. The present invention is especially useful for making highly pyrophoric reactive metal or alloy atomized powders, such as atomized magnesium and magnesium alloy powders. The gaseous reactive species (agents) are introduced into the atomization spray chamber at locations downstream of a gas atomizing nozzle as determined by the desired powder or particle temperature for the reactions and the desired thickness of the reaction film.
FILED	Tuesday, April 11, 2017
APPL NO	15/731053
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0088 (20130101) B22F 1/0088 (20130101) B22F 9/16 (20130101) B22F 9/082 (20130101) B22F 9/082 (20130101) B22F 2009/0844 (20130101) B22F 2201/00 (20130101) B22F 2201/03 (20130101) B22F 2201/10 (20130101) B22F 2999/00 (20130101) B22F 2999/00 (20130101) B22F 2999/00 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 45/30 (20130101) Original (OR) Class
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10766923 — Methods and compositions to increase the rate of ligation reactions catalyzed by a sortase

US 10766923	Clubb et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Robert T. Clubb (Culver City, California); Brendan R. Amer (Los Angeles, California)
ABSTRACT	In various embodiments methods and compositions to increase the rate and/or activity of ligation reactions catalyzed by a sortase. In certain embodiments reagents are provided that comprises, inter alia, a polypeptide comprising an amino terminal polyglycine sequence comprising at least three contiguous Gly residues (e.g., a triglycine sequence, a tetraglycine sequence, a pentaglycine sequence, etc.) followed by a peptide that is to be ligated to a moiety followed by a sequence comprising the catalytic domain of a Sortase A enzyme.
FILED	Thursday, January 26, 2017
APPL NO	16/072155
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 1/13 (20130101) Original (OR) Class C07K 7/06 (20130101) C07K 14/35 (20130101) C07K 14/47 (20130101) C07K 2319/00 (20130101) C07K 2319/21 (20130101) C07K 2319/35 (20130101) C07K 2319/50 (20130101) C07K 2319/90 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) C12N 15/52 (20130101) C12N 15/63 (20130101) C12N 15/113 (20130101) C12N 2310/3181 (20130101) C12N 2310/3517 (20130101) Enzymes C12Y 304/2207 (20130101)
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10766927 — Peptides that stimulate subcutaneous adipogenesis

US 10766927	Turley et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Eva A. Turley (London, Canada); Seyed Bahram Bahrami (Emeryville, California); Mina J. Bissell (Berkeley, California)
ABSTRACT	Peptides of 5 to 14 amino acids in length that stimulate subcutaneous adipogenesis and uses thereof are provided.
FILED	Monday, November 25, 2013
APPL NO	14/089445
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 8/64 (20130101) A61K 31/167 (20130101) A61K 38/00 (20130101) A61K 38/03 (20130101) A61K 38/08 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/001 (20130101) A61Q 19/08 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) Original (OR) Class C07K 14/70596 (20130101)
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10767027 — Magnetically-recoverable catalysts for depolymerization

US 10767027	Sun et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); The Regents of the University of California (Oakland, California)
INVENTOR(S)	Jian Sun (Albany, California); Blake A. Simmons (San Francisco, California); Seema Singh (Clarksburg, Maryland)
ABSTRACT	The present invention relates, in part, to methods for depolymerizing a polymer, in which the method includes use of a magnetic catalyst. The magnetic catalyst can include, e.g., a ore-shell particle, such as a particle having a magnetic core and a shell including a metal-organic framework.
FILED	Thursday, October 17, 2019
APPL NO	16/656245
ART UNIT	1622 — Organic Chemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/745 (20130101) B01J 31/28 (20130101) B01J 31/1691 (20130101) B01J 35/0013 (20130101) B01J 35/0033 (20130101) B01J 2231/005 (20130101) B01J 2531/002 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/28 (20130101) Original (OR) Class C08J 2367/02 (20130101)
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10767062 — System and method for forming activated carbon aerogels and performing 3D printing

US 10767062	Chandrasekaran et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Swetha Chandrasekaran (Livermore, California); Theodore F. Baumann (Livermore, California); Marcus A. Worsley (Livermore, California)
ABSTRACT	Making a carbon aerogel involves 3-D printing an ink to make a printed part, removing the solvent from the printed part, and carbonizing the printed part (with the solvent removed) to make the aerogel. The ink is based on a solution of a resorcinol-formaldehyde resin (RF resin), water, and an organic thickener. Advantageously, the RF resin contains an acid catalyst, which tends to produce carbon aerogels with higher surface areas upon activation than those produced from methods involving an ink composition containing a base catalyzed resin.
FILED	Monday, June 05, 2017
APPL NO	15/613630
ART UNIT	1761 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2061/04 (20130101) B29K 2401/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/03 (20130101) C09D 11/103 (20130101) Original (OR) Class Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/32 (20130101) H01G 11/52 (20130101) H01G 11/86 (20130101)
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10767112 — Methods of producing metal sulfides, metal selenides, and metal sulfides/selenides having controlled architectures using kinetic control

US 10767112	Owen et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); Gregory T. Cleveland (Missouri City, Texas); Ilan Jen-La Plante (New York, New York); Leslie Sachiyo Hamachi (New York, New York)
ASSIGNEE(S)	The Trustees of the Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Jonathan S. Owen (New York, New York); Mark P. Hendricks (Richland, Washington); Michael P. Campos (New York, New York); Gregory T. Cleveland (Missouri City, Texas); Ilan Jen-La Plante (New York, New York); Leslie Sachiyo Hamachi (New York, New York)
ABSTRACT	The present invention is directed to methods of preparing metal sulfide, metal selenide, or metal sulfide/selenide nanoparticles and the products derived therefrom. In various embodiments, the nanoparticles are derived from the reaction between precursor metal salts and certain sulfur- and/or selenium-containing precursors each independently having a structure of Formula (I), (II), or (III), or an isomer, salt, or tautomer thereof, where Q¹, Q², Q³, R¹, R², R³, R⁵, and X are defined within the specification.
FILED	Friday, January 15, 2016
APPL NO	15/541937
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/04 (20130101) C01B 19/007 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 1/12 (20130101) C01G 3/12 (20130101) C01G 9/08 (20130101) C01G 11/02 (20130101) C01G 19/00 (20130101) C01G 19/006 (20130101) C01G 21/21 (20130101) C01G 53/11 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/84 (20130101) C01P 2004/04 (20130101) C01P 2004/16 (20130101) C01P 2004/24 (20130101) C01P 2004/32 (20130101) C01P 2004/64 (20130101) C01P 2004/80 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/565 (20130101) C09K 11/582 (20130101) C09K 11/602 (20130101) C09K 11/661 (20130101) C09K 11/881 (20130101) C09K 11/883 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/04 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/95 (20130101) Y10S 977/774 (20130101) Y10S 977/824 (20130101) Y10S 977/825 (20130101) Y10S 977/892 (20130101) Y10S 977/896 (20130101)
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10767188 — Methods and compositions for obtaining useful plant traits

US 10767188	Mackenzie et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Integrative Organismal Systems (IOS) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	NUtech Ventures (Lincoln, Nebraska)
ASSIGNEE(S)	NUTECH VENTURES (Lincoln, Nebraska)
INVENTOR(S)	Sally Mackenzie (Lincoln, Nebraska); Michael Fromm (Lincoln, Nebraska); Kamaldeep Virdi (Lincoln, Nebraska); Yashitola Wamboldt (Lincoln, Nebraska)
ABSTRACT	The present invention provides methods for obtaining plants that exhibit useful traits by perturbation of plastid function in plant rootstocks and grafting the rootstocks to scions. Methods for identifying genetic loci that provide for useful traits in plants and plants produced with those loci are also provided. In addition, plants that exhibit the useful traits, parts of the plants including seeds, and products of the plants are provided as well as methods of using the plants. Recombinant DNA vectors and transgenic plants comprising those vectors that provide for plastid perturbation are also provided.
FILED	Wednesday, September 24, 2014
APPL NO	14/495498
ART UNIT	1662 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/827 (20130101) C12N 15/8218 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) C12N 15/8271 (20130101) C12N 15/8273 (20130101) Original (OR) Class
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10767194 — RNA-guided transcriptional regulation

US 10767194	Church et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Office of Science Consolidated Service Center (CSC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	George M. Church (Brookline, Massachusetts); Prashant G. Mali (La Jolla, California); Kevin M. Esvelt (Auburndale, Massachusetts)
ABSTRACT	Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.
FILED	Friday, June 14, 2019
APPL NO	16/441209
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/635 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/3513 (20130101) Enzymes C12Y 301/00 (20130101)
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10767196 — Engineering an increase in ethanol production by altering cofactor specificity

US 10767196	Lo et al.
FUNDED BY	Department of Energy (DOE) BioEnergy Science Center (BESC) Office of Science (DOE-SC)
APPLICANT(S)	Enchi Corporation (Wellesley Hills, Massachusetts); Dartmouth College (Hanover, New Hampshire); UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	Enchi Corporation (Wellesley Hills, Massachusetts); Dartmouth College (Hanover, New Hampshire); UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Jonathan Lo (Hanover, New Hampshire); Adam M. Guss (Knoxville, Tennessee); Johannes P. Van Dijken (Scheidam, Netherlands); Arthur J. Shaw, IV (Grantham, New Hampshire); Daniel G. Olson (Norwich, Vermont); Christopher D. Herring (Lebanon, New Hampshire); D. Aaron Argyros (White River Junction, Vermont); Nicky Caiazza (Rancho Santa Fe, California)
ABSTRACT	The present invention provides for the manipulation of cofactor usage in a recombinant host cell to increase the formation of desirable products. In some embodiments, the invention provides for a recombinant microorganism comprising a mutation in one or more native enzymes such that their cofactor specificity is altered in such a way that overall cofactor usage in the cell is balanced for a specified pathway and there is an increase in a specific product formation within the cell. In some embodiments, endogenous enzymes are replaced by enzymes with an alternate cofactor specificity from a different species.
FILED	Friday, November 30, 2012
APPL NO	14/361948
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 15/74 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/06 (20130101) Original (OR) Class Enzymes C12Y 101/01001 (20130101) C12Y 101/01002 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/17 (20130101)
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10767465 — Simulating current flow through a well casing and an induced fracture

US 10767465	Bartel
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Lewis C. Bartel (Albuquerque, New Mexico)
ABSTRACT	A system includes a receiver component that receives a model of a well system, the model comprising a representation of an electrically energized well casing and/or a fracture as a transmission line that leaks electric current as the current traverses the well casing and/or fracture. The receiver component also receives a value that indicates an amount of the current that is applied to the well casing and a location of a source of the current on the well casing. The system further includes an electromagnetic field calculator component that calculates an estimated electromagnetic field at at least one location on the surface of the earth based at least in part upon the representation of the electrically energized well casing and/or fracture, the value that indicates the amount of current that is applied to the well casing, and the location of the source of the current on the well casing.
FILED	Monday, January 23, 2017
APPL NO	15/412374
ART UNIT	2127 — AI & Simulation/Modeling
CURRENT CPC	Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 17/003 (20130101) E21B 41/0092 (20130101) E21B 43/26 (20130101) E21B 47/02224 (20130101) Original (OR) Class Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/20 (20130101) G01V 99/005 (20130101) Electric Digital Data Processing G06F 17/11 (20130101) G06F 30/30 (20200101) G06F 2111/10 (20200101)
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10767617 — Survivability of wave energy convertors

US 10767617	Mundon et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Oscilla Power, Inc. (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S)	Timothy R Mundon (Seattle, Washington); Brian Rosenberg (Seattle, Washington); Andrew Gill (Seattle, Washington); Ben Ackers (Seattle, Washington); Ian McCauley (Brier, Washington); Ken Fitzgerald (Vashon, Washington)
ABSTRACT	A wave energy conversion (WEC) system includes a float body, a heave plate, a tether, and a controller. The tether couples the heave plate to the float body. The controller controls the tether between survivability modes. Each survivability mode adjusts a tension and/or length of the tether.
FILED	Tuesday, April 30, 2019
APPL NO	16/399989
ART UNIT	3678 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Machines or Engines for Liquids F03B 13/1895 (20130101) Original (OR) Class F03B 15/00 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2270/18 (20130101)
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10767670 — Fluid-powered linear motor with rotary pistons and motion rectifier

US 10767670	Raymond
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	David W. Raymond (Edgewood, New Mexico)
ABSTRACT	A fluid-powered linear motor with rotary pistons is disclosed. An application is for a downhole motor but it could be used in other applications. Rotational pistons provide increased torque generation as the torque generated is proportional to motor length. Since downhole drills are long (generally up to a maximum length of 30 ft.), a high-torque motor can be produced using this method. A pressurized fluid is used to drive the piston assemblies to produce bit shaft power. This concept employs rotary pistons and a mechanical rectifier to convert the rotational reciprocation produced by a reciprocating rotational piston into continuous rotary motion.
FILED	Friday, October 05, 2018
APPL NO	16/153265
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 4/02 (20130101) Machines or Engines, in General or of Positive-displacement Type, e.g Steam Engines F01B 11/04 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/02 (20130101) Original (OR) Class Gearing F16H 25/2204 (20130101) F16H 49/00 (20130101) F16H 49/001 (20130101) F16H 2049/008 (20130101)
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10767861 — Method and apparatus for capturing carbon dioxide during combustion of carbon containing fuel

US 10767861	Axelbaum et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	Richard L. Axelbaum (St. Louis, Missouri); Benjamin M. Kumfer (St. Louis, Missouri); Fei Xia (St. Louis, Missouri); Akshay Gopan (Delhi, India); Bhupesh Dhungel (St. Louis, Missouri)
ASSIGNEE(S)	Washington University (St. Louis, Missouri)
INVENTOR(S)	Richard L. Axelbaum (St. Louis, Missouri); Benjamin M. Kumfer (St. Louis, Missouri); Fei Xia (St. Louis, Missouri); Akshay Gopan (Delhi, India); Bhupesh Dhungel (St. Louis, Missouri)
ABSTRACT	A boiler system having a series of boilers. Each boiler includes a shell having an upstream end, a downstream end, and a hollow interior. The boilers also have an oxidizer inlet entering the hollow interior adjacent the upstream end of the shell and a fuel nozzle positioned adjacent the upstream end of the shell for introducing fuel into the hollow interior of the shell. Each boiler includes a flue duct connected to the shell adjacent the downstream end for transporting flue gas from the hollow interior. Oxygen is delivered to the oxidizer inlet of the first boiler in the series. Flue gas from the immediately preceding boiler in the series is delivered through the oxidizer inlet of each boiler subsequent to the first boiler in the series.
FILED	Tuesday, February 27, 2018
APPL NO	15/907055
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Methods of Steam Generation; Steam Boilers F22B 1/22 (20130101) F22B 31/04 (20130101) F22B 33/00 (20130101) F22B 33/12 (20130101) F22B 33/18 (20130101) Methods or apparatus for combustion using fluid fuel or Solid Fuel Suspended In Air F23C 6/00 (20130101) F23C 7/00 (20130101) Removal or Treatment of Combustion Products or Combustion Residues; Flues F23J 15/02 (20130101) F23J 2215/50 (20130101) F23J 2219/70 (20130101) Supplying Air or Non-combustible Liquids or Gases to Combustion Apparatus in General; Valves or Dampers Specially Adapted for Controlling Air Supply or Draught in Combustion Apparatus; Inducing Draught in Combustion Apparatus; Tops for Chimneys or Ventilating Shafts; Terminals for Flues F23L 7/007 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 20/344 (20130101)
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10768082 — System and method for testing true stress and true strain

US 10768082	Wenski
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Kansas City National Security Campus (KCNSC) NNSA Critical Mission Site Operated by Honeywell Federal Manufacturing and Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S)	HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
ASSIGNEE(S)	Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S)	Edward Wenski (Lenexa, Kansas)
ABSTRACT	A true stress testing system broadly comprising a force input machine, an imaging system, and a computer. The imaging system includes a light source for projecting a light beam at the specimen in a first direction and a camera positioned on an opposite side of the specimen for receiving portions of the light beam not blocked by the specimen such that a shadow image of the specimen is created via the camera. The computer may determine a minimum dimension of the specimen perpendicular to the first direction at a point in time over a plurality of points along the force axis via the shadow image of the specimen such that the processor accounts for changes in position of the minimum dimension along the specimen. A true stress of the specimen may then be determined according to the minimum dimension of the specimen perpendicular to the first direction at the point in time.
FILED	Tuesday, May 07, 2019
APPL NO	16/404918
ART UNIT	2487 — Recording and Compression
CURRENT CPC	Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/24 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/081 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/08 (20130101) G01N 3/068 (20130101) Original (OR) Class G01N 2203/0264 (20130101) G01N 2203/0647 (20130101) Image Data Processing or Generation, in General G06T 7/62 (20170101) Pictorial Communication, e.g Television H04N 5/247 (20130101) H04N 5/2256 (20130101)
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10768202 — Systems and methods for nano-tribological manufacturing of nanostructures

US 10768202	Carpick et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
INVENTOR(S)	Robert W. Carpick (Philadelphia, Pennsylvania); Harmandeep S. Khare (Philadelphia, Pennsylvania); Nitya Nand Gosvami (Philadelphia, Pennsylvania); Imene Lahouij (Philadelphia, Pennsylvania)
ABSTRACT	The presently disclosed subject matter provides systems and methods for generating nanostructures from tribological films. A probe tip can be immersed in a liquid mixture comprising a plurality of ink particles suspended in a medium. A substrate on which the tribological film is to be generated can also be immersed in the liquid mixture. A processor controlling movement of the probe tip can be configured to cause the probe tip to slide along the substrate in a shape of a desired pattern of the nanostructure with a contact force to cause one or more ink particles of the plurality of ink particles compressed underneath the probe tip to be transformed into a tribological film onto the substrate in the shape of the desired pattern of the nanostructure.
FILED	Monday, August 29, 2016
APPL NO	15/747183
ART UNIT	2881 — Optics
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 35/00 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 10/065 (20130101) G01Q 20/02 (20130101) G01Q 30/14 (20130101) G01Q 60/26 (20130101) G01Q 60/42 (20130101) Original (OR) Class G01Q 70/14 (20130101) G01Q 80/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101)
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10769017 — Adaptive multi-level checkpointing

US 10769017	Xu et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	Cong Xu (Palo Alto, California); Itir Akgun (Palo Alto, California); Paolo Faraboschi (Sant Cugat, Spain)
ABSTRACT	In some examples, with respect to adaptive multi-level checkpointing, a transfer parameter associated with transfer of checkpoint data from a node-local storage to a parallel file system may be ascertained for the checkpoint data stored in the node-local storage. The transfer parameter may be compared to a specified transfer parameter threshold. A determination may be made, based on the comparison of the transfer parameter to the specified transfer parameter threshold, as to whether to transfer the checkpoint data from the node-local storage to the parallel file system.
FILED	Monday, April 23, 2018
APPL NO	15/960302
ART UNIT	2113 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Electric Digital Data Processing G06F 11/1407 (20130101) Original (OR) Class G06F 11/1438 (20130101) G06F 11/1451 (20130101) G06F 11/1464 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/1095 (20130101) H04L 67/1097 (20130101)
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10769158 — Computer processing through distance-based quality score method in geospatial-temporal semantic graphs

US 10769158	Brost et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions od Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Randolph Brost (Albuquerque, New Mexico); Diane Woodbridge (Corte Madera, California)
ABSTRACT	A computer-implemented method of improving processing of overhead image data by a processor using a distance-based quality score in a geospatial-temporal semantic graph. An allowable range for each attribute in the subgraph search template is defined. For each match in a comparison, attribute values of each match element are compared against the preferred range and the allowable range to compute a corresponding distance of each match attribute from the subgraph search template. A corresponding overall match quality score is determined for each match from the subgraph search template, wherein determining the corresponding overall match qualities is performed using a corresponding required quality score and a corresponding optional quality score. All corresponding overall match quality scores are sorted into an ordered list and then displayed.
FILED	Tuesday, May 15, 2018
APPL NO	15/980578
ART UNIT	2161 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/248 (20190101) G06F 16/9024 (20190101) G06F 16/24578 (20190101) Original (OR) Class
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10769236 — Battery models, systems, and methods using robust fail-safe iteration free approach for solving differential algebraic equations

US 10769236	Sonawane et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	University of Washington (Seattle, Washington); Washington University (St. Louis, Missouri)
ASSIGNEE(S)	University of Washington (Seattle, Washington); Washington University (St. Louis, Missouri)
INVENTOR(S)	Dayaram Sonawane (Seattle, Washington); Manan Pathak (Seattle, Washington); Venkat Subramanian (Seattle, Washington); Matthew Lawder (St. Louis, Missouri)
ABSTRACT	Battery models using robust fail-safe iteration free approach for solving Differential Algebraic Equations, and associated systems and methods are disclosed. In one embodiment, a method includes generating a model of the rechargeable battery; determining one or more initial conditions for one or more algebraic variables of the model using a solver; holding differential variables of the model static by a switch function while determining the one or more initial conditions; applying the initial conditions to the model by the switch function; and determining one or more parameters for the rechargeable battery by solving the algebraic and differential equations.
FILED	Wednesday, July 20, 2016
APPL NO	15/745984
ART UNIT	2859 — Printing/Measuring and Testing
CURRENT CPC	Electric Digital Data Processing G06F 17/13 (20130101) Original (OR) Class G06F 30/20 (20200101) G06F 2111/10 (20200101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/44 (20130101) H01M 10/441 (20130101) H01M 2220/20 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0021 (20130101) H02J 7/0047 (20130101) H02J 7/0048 (20200101)
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10769286 — Non-intrusive data authentication systems and methods

US 10769286	Thomas et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Maikael A. Thomas (Albuquerque, New Mexico); Ross W. Hymel (Albuquerque, New Mexico); George T. Baldwin (Albuquerque, New Mexico)
ABSTRACT	Systems and methods are disclosed that create a separate digital and cryptographically secure signal “branch” to a secondary observer from a primary signal path of an information system. The information system may be a measurement system. The secure signal branch is creating without interfering with the primary signal path. In such a manner, the secondary observer may authenticate reported data while not interfering with the signal of the information system.
FILED	Wednesday, November 15, 2017
APPL NO	15/813427
ART UNIT	2432 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/82 (20130101) G06F 21/86 (20130101) G06F 21/602 (20130101) Original (OR) Class G06F 21/604 (20130101) Ciphering or Deciphering Apparatus for Cryptographic or Other Purposes Involving the Need for Secrecy G09C 1/00 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0877 (20130101) H04L 9/3234 (20130101)
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10770239 — High-efficiency and durable optoelectronic devices using layered 2D perovskites

US 10770239	Mohite et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Aditya Mohite (Los Alamos, New Mexico); Hsinhan Tsai (Los Alamos, New Mexico); Wanyi Nie (Los Alamos, New Mexico); Mercouri Kanatzidis (Evanston, Illinois); Konstantinos Stoumpos (Chicago, Illinois)
ABSTRACT	A thin film for an optoelectronic device includes a layered 2D perovskite material. The thin film including the layered 2D perovskite material forms a substantially or nearly single-crystalline highly uniform thin film with strongly preferential out-of-plane alignment of the inorganic perovskite layers. This single-crystalline, highly uniform, and highly aligned thin film of the layered 2D perovskite material may thereby facilitate efficient charge transport in an optoelectronic device.
FILED	Monday, July 03, 2017
APPL NO	15/641142
ART UNIT	2899 — Semiconductors/Memory
CURRENT CPC	Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2059 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0003 (20130101) H01L 51/004 (20130101) H01L 51/005 (20130101) H01L 51/0026 (20130101) H01L 51/0037 (20130101) H01L 51/0047 (20130101) H01L 51/448 (20130101) H01L 51/4253 (20130101)
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10770262 — Apparatus, method and system for imaging and utilization of SEM charged particles

US 10770262	Chandler et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	David W. Chandler (Livermore, California); Kimberlee Chiyoko Celio (Berkeley, California)
ABSTRACT	A scanning electron microscope (SEM) system includes an SEM objective that emits an electron beam toward a sample, causing emission of charged particles including secondary electrons, Auger electrons, backscattered electrons, anions and cations. The SEM system includes electron optics elements that are configured to establish electric fields around the sample that accelerate charged particles toward a detector. A two-dimensional distribution of locations of incidence of the charged particles on the detector is indicative of energies of the charged particles and their emission angles from the sample. A three-dimensional spatial distribution of charged particles emitted from the sample is recovered by performing an Abel transform over the distribution on the detector. The energies and emission angles of the charged particles are then determined from the three-dimensional spatial distribution.
FILED	Wednesday, November 21, 2018
APPL NO	16/198356
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 37/06 (20130101) H01J 37/12 (20130101) H01J 37/20 (20130101) H01J 37/22 (20130101) H01J 37/28 (20130101) H01J 37/244 (20130101) Original (OR) Class H01J 2237/2443 (20130101) H01J 2237/04735 (20130101) H01J 2237/24585 (20130101)
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10770604 — Hybrid perovskite bulk photovoltaic effect devices and methods of making the same

US 10770604	Garten et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado); Colorado School of Mines (Golden, Colorado)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S)	Lauren Marie Garten (Lakewood, Colorado); David Todd Moore (Lakewood, Colorado); David Samuel Ginley (Evergreen, Colorado); Brian Patrick Gorman (Golden, Colorado)
ABSTRACT	The present disclosure relates to a composition that includes a perovskite crystal having a ferroelectric domain aligned substantially parallel to a reference axis. In some embodiments of the present disclosure, the perovskite crystal may include ABX₃, where A is a first cation, B is a second cation, and X is an anion. In some embodiments of the present disclosure, A may include an alkyl ammonium cation. In some embodiments of the present disclosure, B may include a metal element. In some embodiments of the present disclosure, the metal element may include lead. In some embodiments of the present disclosure, X may include a halogen. In some embodiments of the present disclosure, the perovskite crystal may include methylammonium lead iodide.
FILED	Friday, March 23, 2018
APPL NO	15/934656
ART UNIT	1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 211/04 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/032 (20130101) Original (OR) Class H01L 31/068 (20130101) H01L 41/193 (20130101) H01L 51/4206 (20130101) H01L 51/4213 (20130101)
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10770670 — Inverted organic photosensitive devices

US 10770670	Forrest et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Energy (DOE)
APPLICANT(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Stephen R. Forrest (Ann Arbor, Michigan); Rhonda F. Bailey-Salzman (San Ramon, California)
ABSTRACT	The present disclosure relates to organic photosensitive optoelectronic devices grown in an inverted manner. An inverted organic photosensitive optoelectronic device of the present disclosure comprises a reflective electrode, an organic donor-acceptor heterojunction over the reflective electrode, and a transparent electrode on top of the donor-acceptor heterojunction.
FILED	Monday, October 24, 2016
APPL NO	15/332062
ART UNIT	2814 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/228 (20130101) H01L 21/2225 (20130101) H01L 27/302 (20130101) H01L 51/0053 (20130101) H01L 51/0072 (20130101) H01L 51/0078 (20130101) H01L 51/424 (20130101) H01L 51/441 (20130101) H01L 51/442 (20130101) H01L 51/4246 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101)
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10770673 — Highly reliable stacked white organic light emitting device

US 10770673	Forrest et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Stephen R. Forrest (Ann Arbor, Michigan); Caleb Coburn (Ypsilanti, Michigan); Changyeong Jeong (Ann Arbor, Michigan)
ABSTRACT	An organic light emitting device (OLED) is provided that includes a cathode and an anode; a blue emitting layer; and at least two hybrid red/green emitting layers. One of the at least two hybrid red/green emitting layers is a cathode side, red/green emitting layer that is disposed between the cathode and the blue emitting layer. The second of the at least two hybrid red/green emitting layers is an anode side, red/green emitting layer that is disposed between the blue emitting layer and the anode. The OLED emits white light.
FILED	Tuesday, November 27, 2018
APPL NO	16/200895
ART UNIT	2822 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/504 (20130101) H01L 51/5044 (20130101) Original (OR) Class H01L 51/5068 (20130101) H01L 51/5076 (20130101) H01L 51/5084 (20130101) H01L 51/5278 (20130101) H01L 2251/5346 (20130101)
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10770690 — OLED with minimal plasmonic losses

US 10770690	Forrest et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	The Regents of The University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Stephen R. Forrest (Ann Arbor, Michigan); Jongchan Kim (Ann Arbor, Michigan)
ABSTRACT	A top-emitting organic light emitting device (OLED) that comprises: a substrate having an inward side and an outward side; an OLED body that includes a transparent bottom electrode proximate to the inward side of the substrate, an organic emitting layer, and a transparent top electrode in that order; a non-metallic, diffuse reflective layer with a roughened top surface proximate to and facing the bottom transparent electrode; and a high refractive index waveguide layer. The diffuse reflective layer is positioned between the inward side of the substrate and the OLED body, and the waveguide layer is positioned between the diffuse layer and the bottom transparent electrode.
FILED	Tuesday, November 13, 2018
APPL NO	16/189088
ART UNIT	2891 — Semiconductors/Memory
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 5/0221 (20130101) G02B 5/0284 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/5271 (20130101) Original (OR) Class H01L 2251/5315 (20130101)
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10770699 — Stable bromine charge storage in porous carbon electrodes using tetraalkylammonium bromides for reversible solid complexation

US 10770699	Stucky et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California); Oregon State University (Corvallis, Oregon); University of Oregon (Eugene, Oregon)
INVENTOR(S)	Galen D. Stucky (Santa Barbara, California); Brian Evanko (Goleta, California); Seung Joon Yoo (Goleta, California); Jason Lipton (San Rafael, California); Shannon W. Boettcher (Eugene, Oregon); David Xiulei Ji (Happy Valley, Oregon); Xingfeng Wang (Corvallis, Oregon)
ABSTRACT	Electrolytes for use in electric double-layer capacitors (EDLCs; often referred as supercapacitors or ultracapacitors) are disclosed. In one example, the electrolyte comprises viologen in both the anolyte and the catholyte (with bromide). In another example, the electrolyte comprises viologen (in the anolyte) and tetraalkylammonium with bromide (in the catholyte), wherein the tetraalkylammonium is used to achieve solid complexation of bromine in the activated carbon of the cathode. In a third example, a zinc bromine/tetraalkylammonium supercapacitor/battery hybrid is disclosed. Also disclosed is a corrosion resistant bipolar pouch cell that can be used with the electrolyte embodiments described herein.
FILED	Monday, May 22, 2017
APPL NO	15/601811
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Heterocyclic Compounds C07D 213/06 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/19 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/02 (20130101) H01G 11/04 (20130101) H01G 11/16 (20130101) H01G 11/32 (20130101) H01G 11/62 (20130101) H01G 11/64 (20130101) H01G 11/72 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/08 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101)
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10771495 — Cyber-attack detection and neutralization

US 10771495	Mestha et al.
FUNDED BY	Department of Energy (DOE) Office of Electricity (DOE-OE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Lalit Keshav Mestha (North Colonie, New York); Olugbenga Anubi (Niskayuna, New York); Masoud Abbaszadeh (Clifton Park, New York)
ABSTRACT	The example embodiments are directed to a system and method for neutralizing abnormal signals in a cyber-physical system. In one example, the method includes receiving input signals comprising time series data associated with an asset and transforming the input signals into feature values in a feature space, detecting one or more abnormal feature values in the feature space based on a predetermined normalcy boundary associated with the asset, and determining an estimated true value for each abnormal feature value, and performing an inverse transform of each estimated true value to generate neutralized signals comprising time series data and outputting the neutralized signals.
FILED	Thursday, March 09, 2017
APPL NO	15/454144
ART UNIT	2439 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1441 (20130101) Original (OR) Class
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10771903 — Electrostatic graphene speaker

US 10771903	Zhou et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Qin Zhou (Fremont, California); Alexander K. Zettl (Kensington, California)
ABSTRACT	This disclosure provides systems, methods, and apparatus associated with an electrostatically driven graphene speaker. In one aspect, a device includes a graphene membrane, a first frame on a first side of the graphene membrane, and a second frame on a second side of the graphene membrane. The first frame and the second frame both include substantially circular open regions that define a substantially circular portion of the graphene membrane. A first electrode is proximate the first side of the circular portion of the graphene membrane. A second electrode proximate the second side of the circular portion of the graphene membrane.
FILED	Friday, February 07, 2020
APPL NO	16/785089
ART UNIT	2651 — Videophones and Telephonic Communications
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/02 (20130101) H04R 19/005 (20130101) Original (OR) Class H04R 23/002 (20130101) H04R 29/001 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/733 (20130101)
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National Science Foundation (NSF)

10765336 — System and method for planning a patient-specific cardiac procedure

US 10765336	Trayanova et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Natalia A. Trayanova (Baltimore, Maryland); Henry R. Halperin (Baltimore, Maryland); Hermenegild Arevalo (Baltimore, Maryland); Jason Constantino (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Natalia A. Trayanova (Baltimore, Maryland); Henry R. Halperin (Baltimore, Maryland); Hermenegild Arevalo (Baltimore, Maryland); Jason Constantino (Baltimore, Maryland)
ABSTRACT	A method of planning a patient-specific cardiac procedure according to an embodiment of the current invention includes receiving three-dimensional imaging data of a patient's heart, simulating at least one of electrophysiological or electromechanical activity of at least a portion of the patient's heart using the three-dimensional imaging data, and planning the patient-specific cardiac procedure based on the simulating. The cardiac procedure is for providing a preselected alteration of at least one of electrophysiological or electromechanical behavior of the patient's heart.
FILED	Friday, February 10, 2012
APPL NO	13/984741
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/042 (20130101) Original (OR) Class A61B 5/055 (20130101) A61B 5/04021 (20130101) A61B 6/032 (20130101) A61B 6/037 (20130101) A61B 6/466 (20130101) A61B 6/503 (20130101) A61B 6/5223 (20130101) A61B 8/13 (20130101) A61B 8/0883 (20130101) A61B 34/10 (20160201) A61B 2505/05 (20130101) A61B 2576/023 (20130101) Image Data Processing or Generation, in General G06T 19/00 (20130101) G06T 2210/41 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101)
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10765399 — Programmable electronic stethoscope devices, algorithms, systems, and methods

US 10765399	Emmanouilidou et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Science Foundation (NSF)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Dimitra Emmanouilidou (Baltimore, Maryland); James E. West (Baltimore, Maryland); Mounya Elhilali (North Potomac, Maryland); Ian Mclane (Baltimore, Maryland)
ABSTRACT	A digital electronic stethoscope includes an acoustic sensor assembly that includes a body sensor portion and an ambient sensor portion, the body sensor portion being configured to make acoustically coupled contact with a subject while the ambient sensor portion is configured to face away from the body sensor portion so as to capture environmental noise proximate the body sensor portion; a signal processor and data storage system configured to communicate with the acoustic sensor assembly so as to receive detection signals therefrom, the detection signals including an auscultation signal comprising body target sound and a noise signal; and an output device configured to communicate with the signal processor and data storage system to provide at least one of an output signal or information derived from the output signal. The signal processor and data storage system includes a noise reduction system that removes both stationary noise and non-stationary noise from the detection signal to provide a clean auscultation signal substantially free of distortions. The signal processor and data storage system further includes an auscultation sound classification system configured to receive the clean auscultation signal and provide a classification thereof as at least one of a normal breath sound or an abnormal breath sound.
FILED	Monday, October 31, 2016
APPL NO	15/772454
ART UNIT	2655 — Digital Audio Data Processing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/7203 (20130101) A61B 5/7264 (20130101) A61B 7/003 (20130101) A61B 7/04 (20130101) Original (OR) Class A61B 7/026 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) G06N 99/00 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/178 (20130101) G10K 2210/116 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/51 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/63 (20180101)
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10765645 — Sulfur(VI) fluoride compounds and methods for the preparation thereof

US 10765645	Dong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
ASSIGNEE(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S)	Jiajia Dong (Shanghai, China PRC); K. Barry Sharpless (La Jolla, California); Jeffery W. Kelly (La Jolla, California); Aleksandra Baranczak (Gurnee, Illinois); Wentao Chen (Walnut Creek, California)
ABSTRACT	This application describes a compound represented by Formula (I): YZX¹—S(O)(X²)F)_m]_n (I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X¹is a covalent bond or —CH₂CH₂—, X²is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.
FILED	Friday, October 12, 2018
APPL NO	16/158608
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) Original (OR) Class A61K 31/14 (20130101) A61K 31/40 (20130101) A61K 31/47 (20130101) A61K 31/53 (20130101) A61K 31/56 (20130101) A61K 31/65 (20130101) A61K 31/70 (20130101) A61K 31/136 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/397 (20130101) A61K 31/407 (20130101) A61K 31/439 (20130101) A61K 31/473 (20130101) A61K 31/485 (20130101) A61K 31/505 (20130101) A61K 31/515 (20130101) A61K 31/655 (20130101) A61K 31/4045 (20130101) A61K 31/4168 (20130101) A61K 31/4245 (20130101) A61K 31/4353 (20130101) A61K 31/4709 (20130101) A61K 31/4745 (20130101) A61K 31/5513 (20130101) A61K 31/7048 (20130101) A61K 38/31 (20130101) A61K 47/54 (20170801) A61K 51/0497 (20130101) Acyclic or Carbocyclic Compounds C07C 305/26 (20130101) C07C 2601/14 (20170501) C07C 2603/18 (20170501) Heterocyclic Compounds C07D 277/82 (20130101) C07D 279/08 (20130101) C07D 295/26 (20130101) C07D 295/088 (20130101) C07D 295/185 (20130101) Peptides C07K 1/02 (20130101) C07K 1/1136 (20130101) C07K 2/00 (20130101)
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10765744 — Magnetic particle conjugates, micelles, and methods of delivering agents

US 10765744	Rinaldi et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Human Resource Development (HRD) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
INVENTOR(S)	Carlos Rinaldi (Gainesville, Florida); Sun Hao (Wilmette, Illinois); Brent S. Sumerlin (Gainesville, Florida)
ABSTRACT	Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MC-NC)), methods of making micelles, methods of using micelles, and the like.
FILED	Friday, April 21, 2017
APPL NO	16/093370
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 41/0028 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 47/34 (20130101) A61K 47/52 (20170801) A61K 47/60 (20170801) A61K 47/6907 (20170801) A61K 47/6923 (20170801)
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10765748 — Composition and methods for tethering bioactive peptides to metal oxide surfaces

US 10765748	Becker et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Matthew Becker (Stow, Ohio); Wen Tang (Akron, Ohio)
ASSIGNEE(S)	University of Akron (Akron, Ohio)
INVENTOR(S)	Matthew Becker (Stow, Ohio); Wen Tang (Akron, Ohio)
ABSTRACT	In various aspects, embodiments of the present invention are directed to a series of multivalent dendrons containing a bioactive peptide domain and surface-binding catechol domains. In some embodiments, these multivalent dendrons were obtained through solid phase synthesis and have a strong binding affinity to metal oxide surfaces such as, TiO₂, ZrO₂, CeO₂, and Fe₃O₄, SiO2, as well as other inorganic surfaces such as hydroxyapatite, silver, fluorapatite, calcium carbonate and gold. These catechol-bearing dendrons provide a fast and efficient method to functionalize a wide range of inorganic materials with bioactive peptides and have the potential to be used in coating orthopaedic implants and fixation devices.
FILED	Monday, July 13, 2015
APPL NO	15/325218
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/10 (20130101) Original (OR) Class Peptides C07K 7/08 (20130101) C07K 14/51 (20130101)
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10766024 — Multicomponent plasmonic photocatalysts consisting of a plasmonic antenna and a reactive catalytic surface: the antenna-reactor effect

US 10766024	Halas et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE)
APPLICANT(S)	William Marsh Rice University (Houston, Texas)
ASSIGNEE(S)	William Marsh Rice University (Houston, Texas)
INVENTOR(S)	Nancy Jean Halas (Houston, Texas); Peter Nordlander (Houston, Texas); Hossein Robatjazi (Houston, Texas); Dayne Francis Swearer (Houston, Texas); Chao Zhang (Houston, Texas); Hangqi Zhao (Houston, Texas); Linan Zhou (Houston, Texas)
ABSTRACT	A multicomponent photocatalyst includes a reactive component optically, electronically, or thermally coupled to a plasmonic material. A method of performing a catalytic reaction includes loading a multicomponent photocatalyst including a reactive component optically, electronically, or thermally coupled to a plasmonic material into a reaction chamber, introducing molecular reactants into the reaction chamber, and illuminating the reaction chamber with a light source.
FILED	Friday, May 11, 2018
APPL NO	15/977843
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/123 (20130101) B01J 19/127 (20130101) B01J 21/04 (20130101) B01J 23/002 (20130101) B01J 23/38 (20130101) B01J 23/44 (20130101) B01J 23/50 (20130101) B01J 23/52 (20130101) B01J 23/58 (20130101) B01J 23/72 (20130101) B01J 23/78 (20130101) B01J 23/8926 (20130101) B01J 23/8946 (20130101) B01J 27/04 (20130101) B01J 27/14 (20130101) B01J 27/20 (20130101) B01J 27/22 (20130101) B01J 27/24 (20130101) B01J 31/06 (20130101) B01J 31/1691 (20130101) B01J 35/002 (20130101) B01J 35/004 (20130101) Original (OR) Class B01J 35/0006 (20130101) B01J 35/006 (20130101) B01J 35/008 (20130101) B01J 35/0013 (20130101) B01J 35/0033 (20130101) B01J 35/1066 (20130101) B01J 37/03 (20130101) B01J 37/0203 (20130101) B01J 37/0225 (20130101) B01J 37/344 (20130101) B01J 2219/00635 (20130101) B01J 2523/00 (20130101) B01J 2523/00 (20130101) B01J 2523/17 (20130101) B01J 2523/22 (20130101) B01J 2523/31 (20130101) B01J 2523/821 (20130101) B01J 2540/66 (20130101)
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10766489 — Model predictive adaptive cruise control for reducing rear-end collision risk with follower vehicles

US 10766489	Tuncali et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Cumhur Erkan Tuncali (Tempe, Arizona); Theodore Pavlic (Tempe, Arizona); Georgios Fainekos (Tempe, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Cumhur Erkan Tuncali (Tempe, Arizona); Theodore Pavlic (Tempe, Arizona); Georgios Fainekos (Tempe, Arizona)
ABSTRACT	Methods of and systems for adaptive cruise control (ACC) of a vehicle include a controller for the vehicle that is configured to execute a computer-implemented model predictive control and a safe spacing policy that reduces collision risk between the vehicle and both a leading vehicle and a following vehicle. The methods include sensing a speed of a leader vehicle in front of the ego vehicle and a distance of the leader vehicle from the ego vehicle, sensing a speed of a follower vehicle behind the ego vehicle and a distance of the follower vehicle from the ego vehicle, and controlling the speed of the ego vehicle to avoid collision with the leader vehicle while reducing risk of the ego vehicle being hit by the follower vehicle.
FILED	Wednesday, September 05, 2018
APPL NO	16/122770
ART UNIT	3667 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/09 (20130101) B60W 30/162 (20130101) Original (OR) Class B60W 2050/0031 (20130101) B60W 2554/801 (20200201) B60W 2554/804 (20200201)
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10766787 — Production of mixed metal oxide nanostructured compounds

US 10766787	Sunkara et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Mathematical Sciences (DMS) Office of The Director (OD) Office of Integrative Activities (OIA)
APPLICANT(S)	University of Louisville Research Foundation, Inc. (Louisville, Kentucky)
ASSIGNEE(S)	University of Louisville Research Foundation, Inc. (Louisville, Kentucky)
INVENTOR(S)	Mahendra Sunkara (Louisville, Kentucky); Babajide Patrick Ajayi (Louisville, Kentucky); Daniel F. Jaramillo-Cabanzo (Louisville, Kentucky); Hugo Apolo Nambo Salgado (Louisville, Kentucky)
ABSTRACT	A method for the rapid and controlled synthesis of mixed metal oxide nanoparticles using relatively low temperature plasma oxidation of liquid droplets of predetermined mixed metal precursors is disclosed. The resulting nanoparticles reflect the metal precursor stoichiometries and the mixed metal oxide's metastable phase can be controlled. The synthesis of mixed transition metal oxide comprising binary metal oxides, ternary mixed metal oxides, quaternary mixed metal oxides and pentanary mixed metal oxides are demonstrated herein.
FILED	Wednesday, November 02, 2016
APPL NO	15/342048
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/081 (20130101) B01J 2219/0877 (20130101) B01J 2219/0898 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/006 (20130101) C01G 45/1264 (20130101) C01G 51/40 (20130101) C01G 53/40 (20130101) C01G 53/50 (20130101) C01G 53/68 (20130101) Original (OR) Class C01G 55/002 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/64 (20130101)
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10767112 — Methods of producing metal sulfides, metal selenides, and metal sulfides/selenides having controlled architectures using kinetic control

US 10767112	Owen et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); Gregory T. Cleveland (Missouri City, Texas); Ilan Jen-La Plante (New York, New York); Leslie Sachiyo Hamachi (New York, New York)
ASSIGNEE(S)	The Trustees of the Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Jonathan S. Owen (New York, New York); Mark P. Hendricks (Richland, Washington); Michael P. Campos (New York, New York); Gregory T. Cleveland (Missouri City, Texas); Ilan Jen-La Plante (New York, New York); Leslie Sachiyo Hamachi (New York, New York)
ABSTRACT	The present invention is directed to methods of preparing metal sulfide, metal selenide, or metal sulfide/selenide nanoparticles and the products derived therefrom. In various embodiments, the nanoparticles are derived from the reaction between precursor metal salts and certain sulfur- and/or selenium-containing precursors each independently having a structure of Formula (I), (II), or (III), or an isomer, salt, or tautomer thereof, where Q¹, Q², Q³, R¹, R², R³, R⁵, and X are defined within the specification.
FILED	Friday, January 15, 2016
APPL NO	15/541937
ART UNIT	1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/04 (20130101) C01B 19/007 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 1/12 (20130101) C01G 3/12 (20130101) C01G 9/08 (20130101) C01G 11/02 (20130101) C01G 19/00 (20130101) C01G 19/006 (20130101) C01G 21/21 (20130101) C01G 53/11 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/84 (20130101) C01P 2004/04 (20130101) C01P 2004/16 (20130101) C01P 2004/24 (20130101) C01P 2004/32 (20130101) C01P 2004/64 (20130101) C01P 2004/80 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/565 (20130101) C09K 11/582 (20130101) C09K 11/602 (20130101) C09K 11/661 (20130101) C09K 11/881 (20130101) C09K 11/883 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/04 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/95 (20130101) Y10S 977/774 (20130101) Y10S 977/824 (20130101) Y10S 977/825 (20130101) Y10S 977/892 (20130101) Y10S 977/896 (20130101)
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10767149 — Microfluidic device for three dimensional and compartmentalized coculture of neuronal and muscle cells, with functional force readout

US 10767149	Kamm et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Roger Dale Kamm (Cambridge, Massachusetts); Sebastien G M Uzel (Cambridge, Massachusetts)
ABSTRACT	The present subject matter provides a microfluidic device that enables the precise and repeatable three dimensional and compartmentalized coculture of muscle cells and neuronal cells. Related apparatus, systems, techniques, and articles are also described.
FILED	Tuesday, June 13, 2017
APPL NO	15/621893
ART UNIT	1799 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/34 (20130101) C12M 25/00 (20130101) C12M 33/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) C12N 2502/081 (20130101) C12N 2502/1335 (20130101) C12N 2513/00 (20130101) C12N 2531/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4833 (20130101) G01N 33/5058 (20130101) G01N 33/5061 (20130101)
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10767164 — Microenvironments for self-assembly of islet organoids from stem cells differentiation

US 10767164	Jin et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	The Research Foundation for The State University of New York (Binghamton, New York)
ASSIGNEE(S)	The Research Foundation for The State University of New York (Binghamton, New York)
INVENTOR(S)	Sha Jin (Vestal, New York); Kaiming Ye (Vestal, New York); Huanjing Bi (Binghamton, New York)
ABSTRACT	Human pluripotent stem cells (hPSCs) are promising cell source to produce therapeutic endocrine cells for diabetes treatment. A gel solution made by decellularized tissue-specific extracellular matrix (dpECM) significantly promotes three-dimensional (3D) islet-like organogenesis during induced hPSC differentiation into endocrine lineages. Islet organoids are self-organized even in a two-dimensional (2D) culture mode. Cells derived from hPSCs differentiated on such ECM coated substrates exhibit similar cellular composition to native pancreatic islets. These cells express islet signature markers insulin, PDX-1, C-peptide, MafA, glucagon, somatostatin, and pancreatic polypeptide, and secrete more insulin in response to glucose level compared to a traditional matrix substrate (Matrigel). The dpECM facilitates generating more C-peptide+/glucagon− cells rather than C-peptide+/glucagon+ cells. Remarkably, dpECM also facilitated intra-organoid vascularity by generating endothelial cells and pericytes. Furthermore, dpECM niches also induced intra-organoid microvascularization during pancreatic differentiation.
FILED	Wednesday, December 13, 2017
APPL NO	15/841004
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/14 (20130101) A61L 27/3633 (20130101) A61L 27/3695 (20130101) A61L 2430/34 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 5/0677 (20130101) Original (OR) Class C12N 5/0696 (20130101) C12N 2501/16 (20130101) C12N 2501/117 (20130101) C12N 2501/599 (20130101) C12N 2533/54 (20130101) C12N 2533/90 (20130101)
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10767188 — Methods and compositions for obtaining useful plant traits

US 10767188	Mackenzie et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Integrative Organismal Systems (IOS) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	NUtech Ventures (Lincoln, Nebraska)
ASSIGNEE(S)	NUTECH VENTURES (Lincoln, Nebraska)
INVENTOR(S)	Sally Mackenzie (Lincoln, Nebraska); Michael Fromm (Lincoln, Nebraska); Kamaldeep Virdi (Lincoln, Nebraska); Yashitola Wamboldt (Lincoln, Nebraska)
ABSTRACT	The present invention provides methods for obtaining plants that exhibit useful traits by perturbation of plastid function in plant rootstocks and grafting the rootstocks to scions. Methods for identifying genetic loci that provide for useful traits in plants and plants produced with those loci are also provided. In addition, plants that exhibit the useful traits, parts of the plants including seeds, and products of the plants are provided as well as methods of using the plants. Recombinant DNA vectors and transgenic plants comprising those vectors that provide for plastid perturbation are also provided.
FILED	Wednesday, September 24, 2014
APPL NO	14/495498
ART UNIT	1662 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/827 (20130101) C12N 15/8218 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) C12N 15/8271 (20130101) C12N 15/8273 (20130101) Original (OR) Class
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10767234 — Methods for microbial screening and identification of targets of interest

US 10767234	Abbas et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Abdennour Abbas (Lauderdale, Minnesota); Minh-Phuong Ngoc Bui (St. Paul, Minnesota)
ABSTRACT	Methods of detecting the presence of microorganisms in a sample, the methods including combining a sample, a reducing agent, an oxidant generator and a chemiluminescent agent, and in some cases a shielding agent, wherein the reducing agent both reduces the oxidant generator to produce an oxidant and reduces one or more disulfide bonds on a surface of a microorganism and wherein the oxidant oxidizes the chemiluminescent agent to produce a luminescent compound; and detecting the presence or absence of a signal to indicate the presence or absence of microorganisms in the sample, wherein the intensity of the chemiluminescent signal is inversely proportional to the amount of microorganisms in the sample.
FILED	Monday, April 02, 2018
APPL NO	15/943000
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6816 (20130101) C12Q 1/6816 (20130101) C12Q 2563/137 (20130101) C12Q 2565/625 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101)
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10767256 — Method of engineering single phase magnetoelectric hexaferrite films

US 10767256	Vittoria
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Carmine Vittoria (Key Biscayne, Florida)
ASSIGNEE(S)
INVENTOR(S)	Carmine Vittoria (Key Biscayne, Florida)
ABSTRACT	A method of making a ferrite thin film is provided in which a portion of the iron ions in the ferrite are substituted by ions of at least one other metal. The substituting ions occupy both tetrahedral and octahedral sites in the unit cell of the ferrite crystal. The method includes placing each of a plurality of targets, one at a time, in close proximity to a substrate in a defined sequence; ablating the target thus placed using laser pulses, thereby causing ions from the target to deposit on the substrate; repeating these steps, thereby generating a film; and annealing the film in the presence of oxygen. The plurality of targets, the sequence of their ablation, and the number of laser pulses that each target is subjected to, are selected so as to allow the substituting ions to occupy both tetrahedral and octahedral sites in the unit cell.
FILED	Wednesday, December 14, 2016
APPL NO	15/378998
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/08 (20130101) C23C 14/28 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/20 (20130101) H01F 41/205 (20130101)
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10767476 — Microbiome based systems, apparatus and methods for the exploration and production of hydrocarbons

US 10767476	Knight et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Biota Technology, Inc. (San Diego, California)
ASSIGNEE(S)	Biota Technology, Inc. (San Diego, California)
INVENTOR(S)	Rob Knight (San Diego, California); Ajay Kshatriya (Oakland, California); John Ely (Houston, Texas); Paul Henshaw (Clayton, California); J. Gregory Caporaso (Flagstaff, Arizona); Dan Knights (St. Paul, Minnesota); Ryan Gill (Denver, Colorado)
ABSTRACT	There are provided methods, systems and processes for the utilization of microbial and related genetic information for use in the exploration, determination, production and recovery of natural resources, including energy sources, and the monitoring, control and analysis of processes and activities.
FILED	Wednesday, July 05, 2017
APPL NO	15/641965
ART UNIT	2864 — Printing/Measuring and Testing
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/62 (20130101) C09K 8/582 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6874 (20130101) C12Q 1/6888 (20130101) C12Q 2600/156 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 21/065 (20130101) E21B 43/00 (20130101) E21B 43/26 (20130101) E21B 43/267 (20130101) E21B 47/11 (20200501) E21B 49/00 (20130101) E21B 49/003 (20130101) E21B 49/08 (20130101) Original (OR) Class E21B 49/086 (20130101) E21B 49/0875 (20200501) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 9/00 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) G16B 20/00 (20190201) G16B 40/00 (20190201) G16B 45/00 (20190201)
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10768085 — Resonantly-driven drop contact-line mobility measurement

US 10768085	Steen et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)	CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S)	Paul H. Steen (Ithaca, New York); Yi Xia (Ithaca, New York)
ABSTRACT	The present disclosure relates to, inter alia, systems and methods for measuring contact-line mobility of a liquid on a solid substrate. The system includes a motion-generation component, a motion-measurement component, and a computer component. The motion-generation component can include an actuator and a controller, the actuator being adapted to mount a solid substrate and effective to impart periodic forcing to the solid substrate when a test droplet of the liquid is deposited thereon, and the controller being adapted to tune frequency and amplitude of the forcing to induce measurable contact-line displacement of the test droplet on the solid substrate. The motion-measurement component includes an image acquisition device adapted for capturing images of the test droplet. The image acquisition device has requisite spatial and temporal resolution to enable acquisition of image data of the test droplet, the image data including contact-line displacement, contact-line speed, and contact angle at or near contact-line.
FILED	Wednesday, July 18, 2018
APPL NO	16/039265
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 13/02 (20130101) Original (OR) Class G01N 2013/0208 (20130101) Image Data Processing or Generation, in General G06T 2207/20072 (20130101)
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10768141 — Isoelectric focusing arrays and methods of use thereof

US 10768141	Herr et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents Of The University Of California (Oakland, California)
INVENTOR(S)	Amy E. Herr (Oakland, California); Augusto M. Tentori (Berkeley, California); Kevin A. Yamauchi (Berkeley, California)
ABSTRACT	Isoelectric focusing devices configured for multiplex separation of sample components of interest in a polymeric separation medium are provided. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays.
FILED	Thursday, September 08, 2016
APPL NO	15/749039
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Separation B01D 57/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44747 (20130101) Original (OR) Class G01N 27/44791 (20130101) G01N 27/44795 (20130101)
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10768180 — Polyelectrolyte-coated polymer dots and related methods

US 10768180	Chiu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Washington through its Center for Commercialization (Seattle, Washington)
ASSIGNEE(S)	UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington)
INVENTOR(S)	Daniel T. Chiu (Seattle, Washington); Yuhui Jin (Painted Post, New York); Fangmao Ye (Seattle, Washington); Changfeng Wu (Changchun, China PRC); Yang-Hsiang Chan (Seattle, Washington)
ABSTRACT	Polymer nanoparticles and related methods are provided. The polymer particles can include polymer dots having a coating including a polyelectrolyte polymer. Methods of making and using the polymer nanoparticles are also provided.
FILED	Friday, July 20, 2018
APPL NO	16/041569
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/0065 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) B82Y 15/00 (20130101) B82Y 40/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/588 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0036 (20130101) H01L 51/0039 (20130101) H01L 51/0043 (20130101) H01L 51/5012 (20130101)
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10768749 — Electronic controller haptic display with simultaneous sensing and actuation

US 10768749	Olley et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	Tanvas, Inc. (Chicago, Illinois); Northwestern University (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois); TANVAS, INC. (Chicago, Illinois)
INVENTOR(S)	Michael F. D. Olley (Lake Zurich, Illinois); Michael A. Peshkin (Evanston, Illinois); James E. Colgate (Evanston, Illinois)
ABSTRACT	A haptic touch interface having simultaneous sensing and actuation including an insulating substrate having a front surface and a rear surface and one or more front surface electrodes connected to the front surface of the substrate, wherein the front surface electrodes are arranged in a first pattern. The touch interface further includes one or more rear surface electrodes connected to the rear surface of the substrate, wherein the rear surface electrodes are arranged in a second pattern and the front surface electrodes have a substantial mutual capacitance with the rear surface electrodes. Flying logic is used to control voltages applied to at least one of the front and rear surface electrodes.
FILED	Friday, January 04, 2019
APPL NO	16/240330
ART UNIT	2643 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Electric Digital Data Processing G06F 3/016 (20130101) G06F 3/044 (20130101) G06F 3/0412 (20130101) G06F 3/0418 (20130101) Original (OR) Class G06F 2203/04104 (20130101) G06F 2203/04111 (20130101)
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10769312 — Method and apparatus for trusted display on untrusted computing platforms to secure applications

US 10769312	Gligor et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
INVENTOR(S)	Virgil D. Gligor (Pittsburgh, Pennsylvania); Zongwei Zhou (Mountain View, California); Miao Yu (Pittsburgh, Pennsylvania)
ABSTRACT	This invention provides a method for providing trusted display to security sensitive applications on untrusted computing platforms. This invention has a minimal trusted code base and maintains full compatibility with the computing platforms, including their software and hardware. The core of our invention is a GPU separation kernel that (1) defines different types of GPU objects, (2) mediates access to security-sensitive GPU objects, and (3) emulates accesses to security-sensitive GPU objects whenever required by computing platform compatibility.
FILED	Thursday, October 06, 2016
APPL NO	15/752450
ART UNIT	2438 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 9/45508 (20130101) G06F 9/45558 (20130101) G06F 21/53 (20130101) G06F 21/57 (20130101) G06F 21/62 (20130101) G06F 21/70 (20130101) G06F 21/71 (20130101) G06F 21/84 (20130101) Original (OR) Class G06F 2221/2141 (20130101) G06F 2221/2149 (20130101)
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10769384 — Systems and methods for intelligently configuring and deploying a machine learning-based dialogue system

US 10769384	Mars et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Clinc, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)	Clinc, Inc. (Ann Arbor, Michigan)
INVENTOR(S)	Jason Mars (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan); Parker Hill (Ann Arbor, Michigan); Yiping Kang (Ann Arbor, Michigan); Yunqi Zhang (Ann Arbor, Michigan)
ABSTRACT	A system and method for intelligently configuring a machine learning-based dialogue system includes a conversational deficiency assessment of a target dialog system, wherein implementing the conversational deficiency assessment includes: (i) identifying distinct corpora of mishandled utterances based on an assessment of the distinct corpora of dialogue data; (ii) identifying candidate corpus of mishandled utterances from the distinct corpora of mishandled utterances as suitable candidates for building new dialogue competencies for the target dialogue system if candidate metrics of the candidate corpus of mishandled utterances satisfy a candidate threshold; building the new dialogue competencies for the target dialogue system for each of the candidate corpus of mishandled utterances having candidate metrics that satisfy the candidate threshold; and configuring a dialogue system control structure for the target dialogue system based on the new dialogue competencies, wherein the dialogue system control structure governs an operation of an automated dialogue agent.
FILED	Tuesday, March 10, 2020
APPL NO	16/814125
ART UNIT	2659 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 40/30 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101)
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10769845 — System and method of virtual plant field modelling

US 10769845	Redden et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Blue River Technology Inc. (Sunnyvale, California)
ASSIGNEE(S)	BLUE RIVER TECHNOLOGY INC. (Sunnyvale, California)
INVENTOR(S)	Lee Kamp Redden (Stanford, California); Nicholas Apostoloff (Sunnyvale, California)
ABSTRACT	A technique for generating virtual models of plants in a field is described. Generally, this includes recording images of plants in-situ; generating point clouds from the images; generating skeleton segments from the point cloud; classifying a subset of skeleton segments as unique plant features using the images; and growing plant skeletons from skeleton segments classified as unique plant feature. The technique may be used to generate a virtual model of a single, real plant, a portion of a real plant field, and/or the entirety of the real plant field. The virtual model can be analyzed to determine or estimate a variety of individual plant or plant population parameters, which in turn can be used to identify potential treatments or thinning practices, or predict future values for yield, plant uniformity, or any other parameter can be determined from the projected results based on the virtual model.
FILED	Monday, June 04, 2018
APPL NO	15/996810
ART UNIT	2616 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/33 (20170101) G06T 7/74 (20170101) G06T 7/194 (20170101) G06T 7/337 (20170101) G06T 7/344 (20170101) G06T 15/08 (20130101) G06T 17/05 (20130101) Original (OR) Class G06T 17/20 (20130101) G06T 2210/56 (20130101) G06T 2219/2008 (20130101)
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10770169 — Method of providing a treatment to a subject based on a dynamic pathway map

US 10770169	Vaske et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI)
APPLICANT(S)	Charles J. Vaske (Santa Cruz, California); Stephen C. Benz (Santa Cruz, California); Joshua M. Stuart (Santa Cruz, California); David Haussler (Santa Cruz, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Charles J. Vaske (Santa Cruz, California); Stephen C. Benz (Santa Cruz, California); Joshua M. Stuart (Santa Cruz, California); David Haussler (Santa Cruz, California)
ABSTRACT	The present invention relates to methods for evaluating the probability that a patient's diagnosis may be treated with a particular clinical regimen or therapy.
FILED	Friday, April 29, 2011
APPL NO	13/068002
ART UNIT	3619 — Semiconductors/Memory
CURRENT CPC	Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class G16B 25/00 (20190201) G16B 40/00 (20190201) Technologies for Adaptation to Climate Change Y02A 90/26 (20180101)
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10770170 — Signal encoding and decoding in multiplexed biochemical assays

US 10770170	Kartalov et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Emil P. Kartalov (Pasadena, California); Aditya Rajagopal (Orange, California); Axel Scherer (Pasadena, California)
ABSTRACT	This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
FILED	Wednesday, March 07, 2018
APPL NO	15/914356
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6825 (20130101) C12Q 1/6851 (20130101) C12Q 1/6851 (20130101) C12Q 2537/101 (20130101) C12Q 2537/143 (20130101) C12Q 2537/165 (20130101) C12Q 2563/107 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) Electric Digital Data Processing G06F 17/10 (20130101) G06F 17/11 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 25/00 (20190201) Original (OR) Class G16B 25/20 (20190201) G16B 40/00 (20190201) G16B 40/10 (20190201) Technologies for Adaptation to Climate Change Y02A 50/53 (20180101)
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10770342 — Devices and methods for radiation hardening integrated circuits using shallow trench isolation

US 10770342	Donnelly
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	TallannQuest LLC (Sachse, Texas)
ASSIGNEE(S)	TallannQuest LLC (Plano, Texas)
INVENTOR(S)	Emily Ann Donnelly (Whitesboro, Texas)
ABSTRACT	Designs for radiation hardening CMOS devices and integrated circuits using shallow trench isolation (STI) improve total ionizing dose (TID) radiation response by reducing the leakage currents from source to drain associated with corners and sidewalls of trench insulator edges passing under the gate in an NMOS device while maintaining high breakdown voltage. A silicide block pattern is used in combination with pullback of N+ source and drain regions from at least a portion of these edges of the active region. Additional p-type implants along these edges further increase parasitic threshold voltages and enhance radiation hardness. A process for fabricating devices and integrated circuits incorporating these features is also provided. These techniques and processes are applied to exemplary low-voltage NMOS transistors having straight gates and to high-voltage annular-gate devices, as well as to device-to-device isolation in integrated circuits.
FILED	Sunday, December 23, 2018
APPL NO	16/231552
ART UNIT	2816 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/763 (20130101) H01L 21/76202 (20130101) H01L 21/76224 (20130101) Original (OR) Class H01L 27/092 (20130101) H01L 29/0642 (20130101)
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10770755 — Partially and fully surface-enabled transition metal ion-exchanging energy storage devices

US 10770755	Zhamu et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR) Small Business Technology Transfer (STTR)
APPLICANT(S)	Nanotek Instruments, Inc. (Dayton, Ohio)
ASSIGNEE(S)	Global Graphene Group, Inc. (Dayton, Ohio)
INVENTOR(S)	Aruna Zhamu (Springboro, Ohio); Bor Z. Jang (Centerville, Ohio)
ABSTRACT	A surface-enabled, metal ion-exchanging battery device comprising a cathode, an anode, a porous separator, and a metal ion-containing electrolyte, wherein the metal ion is selected from aluminum (Al), gallium (Ga), indium (In), tin (Sn), lead (Pb), or bismuth (Bi), and at least one of the electrodes contains therein a metal ion source prior to the first charge or discharge cycle of the device and at least the cathode comprises a functional material or nanostructured material having a metal ion-capturing functional group or metal ion-storing surface in direct contact with the electrolyte. This energy storage device has a power density significantly higher than that of a lithium-ion battery and an energy density dramatically higher than that of a supercapacitor.
FILED	Monday, March 05, 2018
APPL NO	15/911758
ART UNIT	1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/366 (20130101) H01M 4/606 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) H01M 10/054 (20130101) H01M 10/0565 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2004/028 (20130101) H01M 2300/0028 (20130101)
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10770972 — Asymmetric switching capacitor regulator

US 10770972	Crossley et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	Lion Semiconductor Inc. (San Francisco, California)
ASSIGNEE(S)	Lion Semiconductor Inc. (San Francisco, California)
INVENTOR(S)	John Crossley (Oakland, California); Hanh-Phuc Le (Superior, Colorado); Alberto Alessandro Angelo Puggelli (Oakland, California)
ABSTRACT	The present disclosure provides an asymmetric switching capacitor regulator that is capable of providing an output voltage, covering a wide voltage range, with a high efficiency. The disclosed switching capacitor regulator is configured to generate a wide range of an output voltage by differentiating a voltage across one or more switching capacitors from a voltage across the rest of the switching capacitors in the switching capacitor regulator.
FILED	Monday, June 10, 2019
APPL NO	16/436203
ART UNIT	2839 — Semiconductors/Memory
CURRENT CPC	Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/14 (20130101) H02M 3/07 (20130101) H02M 3/158 (20130101) Original (OR) Class H02M 2001/007 (20130101) H02M 2001/4291 (20130101) H02M 2003/072 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 70/126 (20130101)
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10771833 — System and method for improving streaming video via better buffer management

US 10771833	Arye et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S)	Matvey Arye (New York, New York); Michael J. Freedman (Princeton, New Jersey)
ABSTRACT	Disclosed are solutions for improving Internet video streaming. A first number is determined based on one or more parameters, including network conditions. A second number is then determined corresponding to a number of video segments that is greater than or equal in size to a third number determined based on a bandwidth-delay product of the network to a remote machine. The second number of video segments is then requested in a pipelined fashion. Pipelined requests are stopped when a predetermined size of the video has been requested that is greater than or equal to the first number. Alternatively, a request is sent to the remote machine to send a portion of the video, where the size of the portion of the video is equal to the first number or equal to the size of video remaining if less than the first number. Combined with pipelining, the approach achieves near-optimal throughput and fast bitrate adaptation, regardless of control plane algorithm.
FILED	Wednesday, May 31, 2017
APPL NO	16/302363
ART UNIT	2456 — Computer Networks
CURRENT CPC	Electric Digital Data Processing G06F 8/4451 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 43/16 (20130101) H04L 43/0864 (20130101) H04L 43/0882 (20130101) H04L 43/0888 (20130101) H04L 43/0894 (20130101) H04L 47/12 (20130101) H04L 47/27 (20130101) H04L 47/29 (20130101) H04L 65/601 (20130101) H04L 65/608 (20130101) H04L 65/4084 (20130101) H04L 67/02 (20130101) H04L 69/16 (20130101) Pictorial Communication, e.g Television H04N 21/2402 (20130101) H04N 21/2662 (20130101) Original (OR) Class H04N 21/6373 (20130101) H04N 21/6379 (20130101) H04N 21/8456 (20130101) H04N 21/8586 (20130101) H04N 21/23439 (20130101) H04N 21/44004 (20130101) H04N 21/44209 (20130101)
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10771903 — Electrostatic graphene speaker

US 10771903	Zhou et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Qin Zhou (Fremont, California); Alexander K. Zettl (Kensington, California)
ABSTRACT	This disclosure provides systems, methods, and apparatus associated with an electrostatically driven graphene speaker. In one aspect, a device includes a graphene membrane, a first frame on a first side of the graphene membrane, and a second frame on a second side of the graphene membrane. The first frame and the second frame both include substantially circular open regions that define a substantially circular portion of the graphene membrane. A first electrode is proximate the first side of the circular portion of the graphene membrane. A second electrode proximate the second side of the circular portion of the graphene membrane.
FILED	Friday, February 07, 2020
APPL NO	16/785089
ART UNIT	2651 — Videophones and Telephonic Communications
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/02 (20130101) H04R 19/005 (20130101) Original (OR) Class H04R 23/002 (20130101) H04R 29/001 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/733 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Small Business Administration (SBA)

10765673 — Methods and compositions useful for treating diseases involving Bcl-2 family proteins with quinoline derivatives

US 10765673	Cardone et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Eutropics Pharmaceuticals, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)	Eutropics Pharmaceuticals, Inc. (Cambridge, Massachusetts)
INVENTOR(S)	Michael H. Cardone (Dorchester, Massachusetts); David J. Richard (Littleton, Massachusetts)
ABSTRACT	The present invention relates to compositions and methods for cancer treatment comprising compounds of Formulae I, II, and III. In some aspects, the invention relates to the treatment of B-cell Lymphoma or other hematopoietic cancers. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as, for example, B-cell lymphoma, using a combination of one or more compounds of Formulae I, II, and III. Combination therapy with, for example, 26S proteasome inhibitors, such as, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formulae I, II, and III. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.
FILED	Monday, April 02, 2018
APPL NO	15/943112
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 31/69 (20130101) A61K 31/454 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/573 (20130101) A61K 31/573 (20130101) A61K 31/4709 (20130101) A61K 31/4709 (20130101) A61K 31/5377 (20130101) A61K 31/5377 (20130101) A61K 38/05 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/5079 (20130101) G01N 2333/82 (20130101) G01N 2500/04 (20130101) G01N 2500/10 (20130101)
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10767476 — Microbiome based systems, apparatus and methods for the exploration and production of hydrocarbons

US 10767476	Knight et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Biota Technology, Inc. (San Diego, California)
ASSIGNEE(S)	Biota Technology, Inc. (San Diego, California)
INVENTOR(S)	Rob Knight (San Diego, California); Ajay Kshatriya (Oakland, California); John Ely (Houston, Texas); Paul Henshaw (Clayton, California); J. Gregory Caporaso (Flagstaff, Arizona); Dan Knights (St. Paul, Minnesota); Ryan Gill (Denver, Colorado)
ABSTRACT	There are provided methods, systems and processes for the utilization of microbial and related genetic information for use in the exploration, determination, production and recovery of natural resources, including energy sources, and the monitoring, control and analysis of processes and activities.
FILED	Wednesday, July 05, 2017
APPL NO	15/641965
ART UNIT	2864 — Printing/Measuring and Testing
CURRENT CPC	Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/62 (20130101) C09K 8/582 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6874 (20130101) C12Q 1/6888 (20130101) C12Q 2600/156 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 21/065 (20130101) E21B 43/00 (20130101) E21B 43/26 (20130101) E21B 43/267 (20130101) E21B 47/11 (20200501) E21B 49/00 (20130101) E21B 49/003 (20130101) E21B 49/08 (20130101) Original (OR) Class E21B 49/086 (20130101) E21B 49/0875 (20200501) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 9/00 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) G16B 20/00 (20190201) G16B 40/00 (20190201) G16B 45/00 (20190201)
VIEW PATENT	@ USPTO: Full Text PDF

10769384 — Systems and methods for intelligently configuring and deploying a machine learning-based dialogue system

US 10769384	Mars et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Clinc, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)	Clinc, Inc. (Ann Arbor, Michigan)
INVENTOR(S)	Jason Mars (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan); Parker Hill (Ann Arbor, Michigan); Yiping Kang (Ann Arbor, Michigan); Yunqi Zhang (Ann Arbor, Michigan)
ABSTRACT	A system and method for intelligently configuring a machine learning-based dialogue system includes a conversational deficiency assessment of a target dialog system, wherein implementing the conversational deficiency assessment includes: (i) identifying distinct corpora of mishandled utterances based on an assessment of the distinct corpora of dialogue data; (ii) identifying candidate corpus of mishandled utterances from the distinct corpora of mishandled utterances as suitable candidates for building new dialogue competencies for the target dialogue system if candidate metrics of the candidate corpus of mishandled utterances satisfy a candidate threshold; building the new dialogue competencies for the target dialogue system for each of the candidate corpus of mishandled utterances having candidate metrics that satisfy the candidate threshold; and configuring a dialogue system control structure for the target dialogue system based on the new dialogue competencies, wherein the dialogue system control structure governs an operation of an automated dialogue agent.
FILED	Tuesday, March 10, 2020
APPL NO	16/814125
ART UNIT	2659 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 40/30 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101)
VIEW PATENT	@ USPTO: Full Text PDF

10769845 — System and method of virtual plant field modelling

US 10769845	Redden et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Blue River Technology Inc. (Sunnyvale, California)
ASSIGNEE(S)	BLUE RIVER TECHNOLOGY INC. (Sunnyvale, California)
INVENTOR(S)	Lee Kamp Redden (Stanford, California); Nicholas Apostoloff (Sunnyvale, California)
ABSTRACT	A technique for generating virtual models of plants in a field is described. Generally, this includes recording images of plants in-situ; generating point clouds from the images; generating skeleton segments from the point cloud; classifying a subset of skeleton segments as unique plant features using the images; and growing plant skeletons from skeleton segments classified as unique plant feature. The technique may be used to generate a virtual model of a single, real plant, a portion of a real plant field, and/or the entirety of the real plant field. The virtual model can be analyzed to determine or estimate a variety of individual plant or plant population parameters, which in turn can be used to identify potential treatments or thinning practices, or predict future values for yield, plant uniformity, or any other parameter can be determined from the projected results based on the virtual model.
FILED	Monday, June 04, 2018
APPL NO	15/996810
ART UNIT	2616 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/33 (20170101) G06T 7/74 (20170101) G06T 7/194 (20170101) G06T 7/337 (20170101) G06T 7/344 (20170101) G06T 15/08 (20130101) G06T 17/05 (20130101) Original (OR) Class G06T 17/20 (20130101) G06T 2210/56 (20130101) G06T 2219/2008 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10770755 — Partially and fully surface-enabled transition metal ion-exchanging energy storage devices

US 10770755	Zhamu et al.
FUNDED BY	National Science Foundation (NSF) Small Business Administration (SBA) Small Business Innovation Research (SBIR) Small Business Technology Transfer (STTR)
APPLICANT(S)	Nanotek Instruments, Inc. (Dayton, Ohio)
ASSIGNEE(S)	Global Graphene Group, Inc. (Dayton, Ohio)
INVENTOR(S)	Aruna Zhamu (Springboro, Ohio); Bor Z. Jang (Centerville, Ohio)
ABSTRACT	A surface-enabled, metal ion-exchanging battery device comprising a cathode, an anode, a porous separator, and a metal ion-containing electrolyte, wherein the metal ion is selected from aluminum (Al), gallium (Ga), indium (In), tin (Sn), lead (Pb), or bismuth (Bi), and at least one of the electrodes contains therein a metal ion source prior to the first charge or discharge cycle of the device and at least the cathode comprises a functional material or nanostructured material having a metal ion-capturing functional group or metal ion-storing surface in direct contact with the electrolyte. This energy storage device has a power density significantly higher than that of a lithium-ion battery and an energy density dramatically higher than that of a supercapacitor.
FILED	Monday, March 05, 2018
APPL NO	15/911758
ART UNIT	1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/366 (20130101) H01M 4/606 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) H01M 10/054 (20130101) H01M 10/0565 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2004/028 (20130101) H01M 2300/0028 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10771159 — Fiber optic patch and voltage conditioning

US 10771159	Nguyen
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Air Systems Command (NAVAIR) Naval Air Warfare Center Aircraft Division (NAWCAD) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	iSenseCloud, Inc. (San Jose, California)
ASSIGNEE(S)	iSenseClound, Inc. (San Jose, California)
INVENTOR(S)	An-Dien Nguyen (Fremont, California)
ABSTRACT	Apparatuses relate generally to a fiber optic cable. In such an apparatus, a housing has a channel or bore for receipt of a portion of the fiber optic cable having a fiber optic sensor. An acoustic interface layer is coupled to a surface of the housing to reduce stress wave coupling loss at an interface between the fiber optic sensor and a host structure surface. In another such apparatus, a patch structure is for a fiber optic cable coupled to a fiber optic voltage conditioner. In yet another such apparatus, a fiber optic voltage conditioner is coupled for optical communication to a fiber optic cable having a Fiber Bragg Grating sensor. The fiber optic voltage conditioner includes a tunable light source having a broadband light source or a gain medium configured to provide a narrowband light signal from a broadband light signal for providing to the fiber optic cable.
FILED	Monday, July 16, 2018
APPL NO	16/036146
ART UNIT	2853 — Printing/Measuring and Testing
CURRENT CPC	Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/22 (20130101) G01K 11/3206 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/246 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 5/0033 (20130101) G01M 11/085 (20130101) Optical Elements, Systems, or Apparatus G02B 6/02114 (20130101) G02B 6/02171 (20130101) G02B 6/02209 (20130101) G02B 6/2938 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/12 (20130101) H01S 5/062 (20130101) H01S 5/0078 (20130101) H01S 5/0617 (20130101) H01S 5/0687 (20130101) H01S 5/02415 (20130101) H01S 5/4025 (20130101) H01S 5/4087 (20130101) H01S 5/06804 (20130101) H01S 5/06808 (20130101) Transmission H04B 10/25 (20130101) Original (OR) Class
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Department of Agriculture (USDA)

10765135 — Production of protein-polysaccharide conjugates

US 10765135	Lucey et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	John A. Lucey (Madison, Wisconsin); Dani Zhu (Madison, Wisconsin); Srinivasan Damodaran (Middleton, Wisconsin)
ASSIGNEE(S)	WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S)	John A. Lucey (Madison, Wisconsin); Dani Zhu (Madison, Wisconsin); Srinivasan Damodaran (Middleton, Wisconsin)
ABSTRACT	The present invention provides novel compositions and methods for producing protein-polysaccharide conjugates in aqueous solutions. Also provided are methods for limiting the Maillard reaction to the very initial stage, the formation of the Schiff base. Provided are methods to obtain a simple product of Schiff base with white color, and compositions obtained using the methods of the present invention.
FILED	Thursday, March 19, 2009
APPL NO	12/407543
ART UNIT	1791 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 21/08 (20130101) Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/08 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 2/66 (20130101) A23L 5/00 (20160801) A23L 27/60 (20160801) A23L 27/84 (20160801) A23L 29/10 (20160801) A23L 29/30 (20160801) Original (OR) Class A23L 33/125 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2002/00 (20130101) A23V 2002/00 (20130101) A23V 2002/00 (20130101) A23V 2002/00 (20130101) A23V 2200/16 (20130101) A23V 2200/222 (20130101) A23V 2200/222 (20130101) A23V 2200/304 (20130101) A23V 2200/304 (20130101) A23V 2250/5042 (20130101) A23V 2250/5042 (20130101) A23V 2250/5042 (20130101) A23V 2250/54246 (20130101) A23V 2250/54252 (20130101) A23V 2250/54252 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/20 (20130101) Peptides C07K 14/4717 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0021 (20130101) Derivatives of Natural Macromolecular Compounds C08H 1/00 (20130101)
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10767188 — Methods and compositions for obtaining useful plant traits

US 10767188	Mackenzie et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Integrative Organismal Systems (IOS) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	NUtech Ventures (Lincoln, Nebraska)
ASSIGNEE(S)	NUTECH VENTURES (Lincoln, Nebraska)
INVENTOR(S)	Sally Mackenzie (Lincoln, Nebraska); Michael Fromm (Lincoln, Nebraska); Kamaldeep Virdi (Lincoln, Nebraska); Yashitola Wamboldt (Lincoln, Nebraska)
ABSTRACT	The present invention provides methods for obtaining plants that exhibit useful traits by perturbation of plastid function in plant rootstocks and grafting the rootstocks to scions. Methods for identifying genetic loci that provide for useful traits in plants and plants produced with those loci are also provided. In addition, plants that exhibit the useful traits, parts of the plants including seeds, and products of the plants are provided as well as methods of using the plants. Recombinant DNA vectors and transgenic plants comprising those vectors that provide for plastid perturbation are also provided.
FILED	Wednesday, September 24, 2014
APPL NO	14/495498
ART UNIT	1662 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/827 (20130101) C12N 15/8218 (20130101) C12N 15/8261 (20130101) C12N 15/8269 (20130101) C12N 15/8271 (20130101) C12N 15/8273 (20130101) Original (OR) Class
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10768177 — Bacteriophage-based electrochemical biosensor

US 10768177	Wu et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S)	Vivian C. Wu (Burlingame, California); Irwin Quintela (El Cerrito, California)
ABSTRACT	A biosensor for detecting bacteria may use bacteriophages in a sandwich-assay system. The biosensor may include a capture element and a detection element. The capture element may include a substrate and a bacteriophage. The detection element may include a bacteriophage and a signal amplification element. The biosensor may be utilized such that the target bacterium is sandwiched between the capture element and the detection element, and a quantifiable signal may be generated to measure the amount of bacteria in a sample. The biosensor of the present invention utilizes direct sensing to detect the bacteria in the sample as opposed to indirect sensing methods.
FILED	Wednesday, August 29, 2018
APPL NO	16/115957
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) G01N 27/3275 (20130101) G01N 33/542 (20130101) G01N 33/56911 (20130101) Original (OR) Class
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10769409 — Culture detection and measurement over time

US 10769409	Robinson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA)
APPLICANT(S)	Joseph Paul Robinson (West Lafayette, Indiana); Bartlomiej P. Rajwa (West Lafayette, Indiana); Valery Patsekin (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Joseph Paul Robinson (West Lafayette, Indiana); Bartlomiej P. Rajwa (West Lafayette, Indiana); Valery Patsekin (West Lafayette, Indiana)
ABSTRACT	A computer method for correlating depictions of colonies of microorganisms includes receiving an image of a substrate associated with a first time and showing a colony of microorganisms. A second image of the same substrate and associated with a second time shows a candidate colony of microorganisms. A region of the second image that shows the candidate colony of microorganisms is located. The first region of the first image is compared to the second region of the second image. Based on the comparison of the images, the candidate colony of microorganism is determined to be the same colony as the first colony of microorganisms. Systems for moving substrates having colonies of microorganisms and maintaining orientation of the substrates before and after movement are also described.
FILED	Thursday, April 21, 2016
APPL NO	15/567928
ART UNIT	2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00147 (20130101) Original (OR) Class G06K 9/6269 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 7/33 (20170101) G06T 2207/10056 (20130101) G06T 2207/30024 (20130101)
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Department of Transportation (USDOT)

10767172 — Method for epoxidation to produce alkene oxide

US 10767172	Corgie et al.
FUNDED BY	Department of Transportation (USDOT)
APPLICANT(S)	CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)	CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S)	Stephane C. Corgie (Ithaca, New York); Xiaonan Duan (Ithaca, New York); Emmanuel Giannelis (Ithaca, New York); Daniel Aneshansley (Ithaca, New York); Larry P. Walker (Ithaca, New York)
ABSTRACT	A hierarchical catalyst composition comprising a continuous or particulate macroporous scaffold in which is incorporated mesoporous aggregates of magnetic nanoparticles, wherein an enzyme is embedded in mesopores of the mesoporous aggregates of magnetic nanoparticles. Methods for synthesizing the hierarchical catalyst composition are also described. Also described are processes that use the recoverable hierarchical catalyst composition for depolymerizing lignin remediation of water contaminated with aromatic substances, polymerizing monomers by a free-radical mechanism, epoxidation of alkenes, halogenation of phenols, inhibiting growth and function of microorganisms in a solution, and carbon dioxide conversion to methanol. Further described are methods for increasing the space time yield and/or total turnover number of a liquid-phase chemical reaction that includes magnetic particles to facilitate the chemical reaction, the method comprising subjecting the chemical reaction to a plurality of magnetic fields of selected magnetic strength, relative position in the chemical reaction, and relative motion.
FILED	Thursday, June 27, 2019
APPL NO	16/454714
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/02 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/00 (20130101) B01J 19/12 (20130101) B01J 31/02 (20130101) B01J 31/003 (20130101) B01J 35/04 (20130101) B01J 35/0033 (20130101) B01J 35/1061 (20130101) B01J 35/1066 (20130101) B01J 37/02 (20130101) B01J 2208/00805 (20130101) B01J 2219/0854 (20130101) B01J 2219/0862 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/484 (20130101) C02F 3/00 (20130101) C02F 3/342 (20130101) C02F 2101/327 (20130101) C02F 2209/006 (20130101) C02F 2303/04 (20130101) C02F 2305/08 (20130101) Acyclic or Carbocyclic Compounds C07C 1/12 (20130101) Heterocyclic Compounds C07D 301/22 (20130101) Compounds of Unknown Constitution C07G 1/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 14/00 (20130101) C08F 18/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0004 (20130101) C12N 9/0006 (20130101) C12N 9/0061 (20130101) C12N 9/0065 (20130101) C12N 11/04 (20130101) Original (OR) Class C12N 11/08 (20130101) C12N 11/14 (20130101) C12N 13/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) C12P 7/22 (20130101) C12P 17/02 (20130101) Enzymes C12Y 101/03004 (20130101) C12Y 111/01 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/588 (20151101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 10/45 (20150501)
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10769459 — Method and system for monitoring driving behaviors

US 10769459	Tamrakar et al.
FUNDED BY	Department of Transportation (USDOT) Federal Highway Administration (FHWA) National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)	SRI International (Menlo Park, California)
INVENTOR(S)	Amir Tamrakar (Philadelphia, Pennsylvania); Gregory Ho (Lawrenceville, New Jersey); David Salter (Bensalem, Pennsylvania); Jihua Huang (Philadelphia, Pennsylvania)
ABSTRACT	A method and a system are provided for monitoring driving conditions. The method includes receiving video data comprising video frames from one or more sensors where the video frames may represent an interior or exterior of a vehicle, detecting and recognizing one or more features from the video data where each feature is associated with at least one driving condition, extracting the one or more features from the video data, developing intermediate features by associating and aggregating the extracted features among the extracted features, and developing a semantic meaning for the at least one driving condition by utilizing the intermediate features and the extracted one or more features.
FILED	Tuesday, August 30, 2016
APPL NO	15/751339
ART UNIT	2663 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00261 (20130101) G06K 9/00281 (20130101) G06K 9/00845 (20130101) Original (OR) Class Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/06 (20130101)
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10769967 — System, method and computer readable medium for quantifying anatomical device deformation under load

US 10769967	Panzer et al.
FUNDED BY	Department of Transportation (USDOT) National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
INVENTOR(S)	Matthew B. Panzer (Charlottesville, Virginia); Jason L. Forman (Charlottesville, Virginia); Jean S. G. Vilar (Delray Beach, Florida); Ahmed Alshareef (Columbia, South Carolina)
ABSTRACT	An automated method and system of determining movement and/or deformation of an anthropomorphic test device (ATD). The method and system includes an acoustic transmitter device located on a first region of the ATD and an acoustic receiver device located on a second region of the ATD. An electric field is provided in communication with the acoustic transmitter to activate the acoustic transmitter for generating mechanical waves to be received by the acoustic receiver. Relative locations of the acoustic transmitter device and the acoustic receiver device are determined by the time of flight of the generated mechanical wave traveling from the acoustic transmitter device to the acoustic receiver device while the first region of the ATD and/or the second region of the ATD are subjected to movement and/or deformation; and determining movement and/or deformation data of the second region of the ATD. Information may be transmitted that represents the movement and/or deformation data of the second region, or information may be presented that represent the movement and/or deformation data of the second region on a display.
FILED	Thursday, January 25, 2018
APPL NO	15/879649
ART UNIT	3715 — Amusement and Education Devices
CURRENT CPC	Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 7/08 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/26 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 9/00 (20130101) G09B 23/32 (20130101) Original (OR) Class G09B 23/285 (20130101) G09B 23/288 (20130101)
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National Aeronautics and Space Administration (NASA)

10767058 — Controlled release materials for anti-corrosion agents

US 10767058	Zhang et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as Represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as Represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Xuejun Zhang (Orlando, Florida); Wenyan Li (New Smyrna Beach, Florida); Luz M. Calle (Merritt Island, Florida)
ABSTRACT	Corrosion inhibitor materials are provided that release active corrosion inhibitor compounds when they are most needed—in response to changes in conditions, including acid or basic pH, that cause corrosion or occur at the early stages of corrosion. The materials comprise particles that can be dispersed in paints and coatings for metals. The particles in some cases include ionic water-soluble anti-corrosion agents complexed to oppositely charged surfactants and entrapped in silica oxide or metal oxide gels.
FILED	Friday, February 26, 2016
APPL NO	15/055247
ART UNIT	1788 — Miscellaneous Articles, Stock Material
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 211/63 (20130101) Heterocyclic Compounds C07D 233/58 (20130101) C07D 277/72 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0012 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/084 (20130101) Original (OR) Class
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10768213 — Software-defined radiometer

US 10768213	Miles et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Lynn R. Miles (District Heights, Maryland); Damon C. Bradley (Laurel, Maryland); Englin Wong (Hanover, Maryland); Alicia T. Joseph (Greenbelt, Maryland)
ABSTRACT	A software-defined radiometer includes dual RF front end channels. One RF front end channel processes the horizontal polarization signals and the other RF front end channel processes the vertical polarization signals. Each RF front end channel includes a power splitter for splitting the polarization signals into a plurality of identical polarization signals, a filter bank of N-bandpass filters that have the same bandwidth but different center frequencies and a multi-input switch. The bandpass filters filter the horizontal and vertical polarization signals and provide a plurality of filtered horizontal and vertical polarization signals. A control circuit issues a control signal to the multi-input switch so as to route a desired one of the plurality of filtered horizontal and vertical polarization signals to a programmable frequency converter. The programmable frequency converter includes a programmable local oscillator that is configured to generate signals having any one of N frequencies and is used to produce intermediate frequency representations of the horizontal and vertical polarization signals. The intermediate frequency representations are converted into digital signals and processed to extract desired information and data.
FILED	Wednesday, August 30, 2017
APPL NO	15/690852
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 23/06 (20130101) G01R 23/16 (20130101) G01R 23/165 (20130101) Original (OR) Class G01R 29/08 (20130101) G01R 29/0878 (20130101)
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10769224 — Space weather database

US 10769224	Wiegand
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Chiu P. Wiegand (Greenbelt, Maryland)
ABSTRACT	The disclosed subject matter relates to a database and systems associated therewith for space weather data (code name DONKI for Database of Notification, Knowledge, Information) relating to various space weather phenomena or phenomenon, such as, for example, solar flare, solar energetic particle, coronal mass ejection, interplanetary shock, magnetopause crossing, geomagnetic storm, radiation belt enhancement and high speed stream.
FILED	Thursday, August 10, 2017
APPL NO	15/674016
ART UNIT	2166 — Data Bases & File Management
CURRENT CPC	Meteorology G01W 1/10 (20130101) Electric Digital Data Processing G06F 16/9038 (20190101) G06F 16/9535 (20190101) Original (OR) Class
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Department of Homeland Security (DHS)

10767210 — Fiber sampler for recovery of bioaerosols and particles

US 10767210	Ensor et al.
FUNDED BY	Department of Homeland Security (DHS) Science and Technology Directorate (DHS-ST)
APPLICANT(S)	Research Triangle Institute (Research Triangle Park, North Carolina)
ASSIGNEE(S)	Research Triangle, Inc. (Research Triangle Park, North Carolina)
INVENTOR(S)	David S. Ensor (Chapel Hill, North Carolina); Howard Jerome Walls (Apex, North Carolina); Karin K. Foarde (Chapel Hill, North Carolina); Susanne Vera Hering (Berkeley, California); Steven Russel Spielman (Berkeley, California)
ABSTRACT	An aerosol collection system and method. The system includes a bio-aerosol delivery device configured to supply bioparticles in a gas stream, a moisture exchange device including a partition member coupled to the gas stream and configured to humidify or dehumidify the bioparticles in the gas stream, and an aerosol collection medium downstream from the moisture exchange device and configured to collect the bioparticles. The method includes delivering bioparticles in a gas stream, humidifying or dehumidifying the bioparticles in the gas stream by transport of water across a partition member and into a vapor phase of the gas stream, and collecting the bioparticles by a collection medium.
FILED	Thursday, June 27, 2019
APPL NO	16/455067
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/24 (20130101) Original (OR) Class
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10771598 — Autonomous mode fixed station interface for legacy base station equipment

US 10771598	Brockway
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	Richard Brockway (Ellicott, Maryland)
ABSTRACT	Various embodiments are directed toward a system and method pertaining to an interface device for provisioning Internet Protocol (IP) communications to be established for base station equipment that employ proprietary device specific protocols. In a conversion mode, a fixed station interface (FSI) translates between a V.24 High-Level-Data-Link Control (HDLC) protocol used for external data connections on base station equipment to a Voice-Over-Internet-Protocol (VOIP) open-standard protocol. In an autonomous mode, the FSI establishes a connection to at least one base station or other FSI automatically without the involvement of a dispatch console. Upon being deployed in First Responder communications networks (that use legacy base station equipment), the FSI provisions for the retention of existing installed base station equipment while providing a low-cost solution to support VOIP communications interconnectivity and reliability, thereby enhancing the effectiveness and safety of the First Responder systems.
FILED	Thursday, November 21, 2019
APPL NO	16/691001
ART UNIT	2416 — Multiplex and VoIP
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 69/08 (20130101) H04L 69/22 (20130101) Original (OR) Class
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Environmental Protection Agency (EPA)

10768150 — Multi-channel multi-dimensional comprehensive gas chromatography

US 10768150	Fan et al.
FUNDED BY	Environmental Protection Agency (EPA)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Xudong Fan (Saline, Michigan); Jiwon Lee (Ann Arbor, Michigan); Menglian Zhou (Ypsilanti, Michigan); Hongbo Zhu (Ann Arbor, Michigan); Katsuo Kurabayashi (Ann Arbor, Michigan)
ABSTRACT	The present disclosure provides a method for conducting comprehensive chromatography analysis. Broadly, the method comprises separating a sample in a first chromatographic column to generate a primary stream, which is directed toward a non-modulator switching system comprising at least one micro-switch and at least one valve. The non-modulator switching system is continuously operated to: (a) selectively direct a portion of the primary stream to one of a plurality of thermal injectors and accumulating the portion of the primary stream for a predetermined amount of time; (b) inject the portion of the primary stream into one of a plurality of secondary chromatographic columns; (c) detect one or more analytes in a secondary stream exiting the secondary chromatographic column; and repeat (a)-(c) to selectively direct other portions of the primary stream to other thermal injectors and secondary chromatographic columns until all of the analytes in the sample are detected.
FILED	Wednesday, October 04, 2017
APPL NO	15/724665
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/463 (20130101) Original (OR) Class G01N 30/465 (20130101) G01N 30/466 (20130101) G01N 30/468 (20130101) G01N 2030/025 (20130101)
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National Security Agency (NSA)

10771404 — Performance monitoring

US 10771404	Keppel et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)	Intel Corporation (Santa Clara, California)
INVENTOR(S)	David Keppel (Mountain View, California); Thomas D. Lovett (Portland, Oregon); Michael A. Parker (Santa Clara, California); Robert C. Zak, Jr. (Bolton, Massachusetts)
ABSTRACT	Particular embodiments described herein provide for a network element that can be configured to receive a request message, wherein the request message includes a read trigger, an indicator selector, and a completion trigger, determine an indicator that relates to the indicator selector, and perform an action when the read trigger is activated.
FILED	Thursday, December 22, 2016
APPL NO	15/388604
ART UNIT	2441 — Computer Networks
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 43/08 (20130101) H04L 43/10 (20130101) H04L 43/16 (20130101) H04L 43/022 (20130101) H04L 49/901 (20130101) Original (OR) Class
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Office of the Director of National Intelligence (ODNI)

10770140 — Memristive array with parallel reset control devices

US 10770140	Strachan et al.
FUNDED BY	Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	John Paul Strachan (San Carlos, California); Brent Buchanan (Palo Alto, California); Le Zheng (Palo Alto, California)
ABSTRACT	The present disclosure provides a memristive array. The array includes a number of memristive devices. A memristive device is switchable between states and is to store information. The memristive array also includes a parallel reset control device coupled to the number of memristive devices in parallel. The parallel reset control device regulates a resetting operation for the number of memristive devices by regulating current flow through target memristive devices.
FILED	Wednesday, January 27, 2016
APPL NO	16/065771
ART UNIT	2825 — Semiconductors/Memory
CURRENT CPC	Static Stores G11C 11/5685 (20130101) G11C 13/003 (20130101) G11C 13/0007 (20130101) G11C 13/0026 (20130101) G11C 13/0028 (20130101) G11C 13/0069 (20130101) Original (OR) Class G11C 13/0097 (20130101) G11C 2213/79 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10769801 — Fast multi-spectral image registration by modeling platform motion

US 10769801	Saquib et al.
FUNDED BY
APPLICANT(S)	Goodrich Corporation (Charlotte, North Carolina)
ASSIGNEE(S)	Goodrich Corporation (Charlotte, North Carolina)
INVENTOR(S)	Suhail Shabbir Saquib (Shrewsbury, Massachusetts); Matthew D. Egan (Westford, Massachusetts)
ABSTRACT	A method of predicting warps for image registration includes receiving warp data for a first band pair in an N-band system. The method includes fitting a warp model to the warp data to produce an offset profile for the first band pair, predicting a respective offset profile for at least one other band pair in the N-band system, and using the predicted respective offset profile to generate a warp for the at least one other band pair. The method also includes registering images of the at least one other band pair using the warp for the at least one other band pair. In another aspect, a method of predicting warps for image registration includes receiving warp data for m band pairs in an N-band system, wherein m≤(N−1) and m>2, to register images.
FILED	Wednesday, December 05, 2018
APPL NO	16/210091
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 3/0093 (20130101) G06T 7/30 (20170101) Original (OR) Class G06T 7/32 (20170101) G06T 2207/10036 (20130101) Pictorial Communication, e.g Television H04N 5/332 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, September 08, 2020.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2020/fedinvent-patents-20200908.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

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