FedInvent™ Patents

Patent Details for Tuesday, September 15, 2020

This page was updated on Monday, March 27, 2023 at 06:11 AM GMT

Department of Health and Human Services (HHS)

10772496 — Method for imaging retinal structures

US 10772496	Rossi
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Ethan Andrew Rossi (Rochester, New York)
ASSIGNEE(S)	University of Rochester (Rochester, New York)
INVENTOR(S)	Ethan Andrew Rossi (Rochester, New York)
ABSTRACT	A method for imaging retinal structures involves offsetting an imaging aperture from the center of the reflected/scattered light distribution. Images are obtained with the imaging aperture at multiple offsets with respect to the center. The various obtained images are co-registered to a reference confocal image in a reference wavelength and averaged to generate high signal to noise ratio images. The images may be combined in various ways to enhance the contrast of retinal structures that would not be visible in confocal images.
FILED	Tuesday, March 08, 2016
APPL NO	15/564676
ART UNIT	2872 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/0025 (20130101) Original (OR) Class A61B 3/1025 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0024 (20130101) G02B 21/0028 (20130101) G02B 21/0064 (20130101) G02B 2207/129 (20130101)
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10772504 — Apparatus, systems and methods for intraoperative imaging

US 10772504	Anwar et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	Regents of the University of California (San Francisco, California)
ASSIGNEE(S)	The Regents of the University of California (San Francisco, California)
INVENTOR(S)	Moshiur M. Anwar (San Francisco, California); Catherine Park (San Francisco, California); Bernard Boser (Berkeley, California)
ABSTRACT	The disclosed apparatus, systems and methods relate to devices, systems and methods for intra-operative imaging.
FILED	Friday, August 25, 2017
APPL NO	15/687205
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Original (OR) Class A61B 5/0084 (20130101) A61B 5/0091 (20130101) A61B 5/4381 (20130101) A61B 5/4836 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0058 (20130101) A61K 49/0067 (20130101)
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10772579 — Systems and methods for reducing radiation dose in CT

US 10772579	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Danny J J Wang (Oak Park, California); Thomas Martin (Los Angeles, California); John M. Hoffman (Los Angeles, California)
ABSTRACT	A low-dose CT imaging system and method that operates according to a pulsed X-ray emission scheme according to a predefined sequence of rotation angles of the X-ray source, along with image reconstruction algorithms to achieve high spatial and temporal resolution for CT scans. The systems and methods involve high speed switching (on the order of milliseconds) to generate pulsed exposure of X-ray radiation to the patient, reducing radiation dose by 4-8 fold, or more.
FILED	Tuesday, November 28, 2017
APPL NO	15/824862
ART UNIT	2884 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/02 (20130101) A61B 6/06 (20130101) A61B 6/032 (20130101) A61B 6/035 (20130101) Original (OR) Class A61B 6/40 (20130101) A61B 6/405 (20130101) A61B 6/542 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) G06T 11/006 (20130101) G06T 2211/412 (20130101) G06T 2211/421 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/02 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 35/30 (20130101) X-ray Technique H05G 1/56 (20130101) H05G 1/60 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 378/901 (20130101)
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10772722 — Polymeric heart valve

US 10772722	Bluestein et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Research Foundation for The State University of New York (Albany, New York); The Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)	The Research Foundation for The State University of New York (Albany, New York); The Arizona Board of Regents on Behalf of the University of Arizona (Tuscon, Arizona)
INVENTOR(S)	Danny Bluestein (Melville, New York); Thomas E. Claiborne (Bayport, New York); Marvin J. Slepian (Tucson, Arizona)
ABSTRACT	A polymeric valve which may include a heart valve, and also may include a trileaflet heart valve includes a stent having a base and a plurality of outwardly extending posts from the base and equidistant from each other. A plurality of leaflets each connected to a corresponding one of the posts at one end, and each of the leaflets connected to the base. Each of the leaflets having an operative end opposite the end connected to the post, and the operative ends of the leaflets being biased in a closed position such that the operative ends abut each other. The operative ends are configured to rhythmically open and close in relation to each other, and the leaflets include multiple cross sectional thicknesses at different portions of the leaflets.
FILED	Thursday, April 20, 2017
APPL NO	15/492227
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2412 (20130101) A61F 2/2415 (20130101) A61F 2/2418 (20130101) Original (OR) Class A61F 2250/0036 (20130101)
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10772742 — Polycentric powered ankle prosthesis

US 10772742	Lenzi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR)
APPLICANT(S)	REHABILITATION INSTITUTE OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)	Rehabilitation Institute of Chicago (Chicago, Illinois)
INVENTOR(S)	Tommaso Lenzi (Chicago, Illinois); Marco Cempini (Chicago, Illinois); Todd Kuiken (Chicago, Illinois)
ABSTRACT	Systems and methods are disclosed for a powered ankle prosthesis. The prosthesis may comprise a polycentric mechanism having a defined path for an instantaneous center of rotation. The path of the instantaneous center of rotation may be defined by a trajectory substantially equal to an arc positioned over a joint of the polycentric mechanism.
FILED	Friday, April 07, 2017
APPL NO	15/482663
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/70 (20130101) A61F 2/6607 (20130101) Original (OR) Class A61F 2002/701 (20130101) A61F 2002/5018 (20130101) A61F 2002/5021 (20130101) A61F 2002/5027 (20130101) A61F 2002/5038 (20130101) A61F 2002/6614 (20130101) A61F 2002/6836 (20130101) A61F 2002/7635 (20130101)
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10772846 — Methods and compositions for treating and preventing arthritis

US 10772846	Sun et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Montefiore Medical Center (Bronx, New York); Albert Einstein College of Medicine (Bronx, New York)
ASSIGNEE(S)	Montefiore Medical Center (Bronx, New York); Albert Einstein College of Medicine (Bronx, New York)
INVENTOR(S)	Hui B. Sun (Chappaqua, New York); Daniel J. Leong (Forest Hills, New York); Neil J. Cobelli (Scarsdale, New York); David M. Hirsh (Scarsdale, New York); John A. Hardin (New York, New York); Karen E. Sperling (New Rochelle, New York); Sun Jin Kim (New York, New York); David C. Spray (Pelham, New York); Chandan Guha (Scarsdale, New York); Marwa Choudhury (Bronx, New York)
ABSTRACT	Methods and formulations are provided for treating or preventing arthritis, in particular osteoarthritis, where the formulation to be administered to a subject for treating or preventing arthritis comprises carvacrol, curcumin, epigallocatechin-3-gallate and oligomeric procyanidins. The invention provides methods of treating or preventing arthritis, such as osteoarthritis, in a subject in need thereof comprising administering to the subject a formulation or composition comprising carvacrol, curcumin, epigallocatechin-3-gallate and oligomeric procyanidins in an amount effective to treat or prevent arthritis.
FILED	Monday, November 02, 2015
APPL NO	15/520156
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/05 (20130101) Original (OR) Class A61K 31/05 (20130101) A61K 31/12 (20130101) A61K 31/12 (20130101) A61K 31/353 (20130101) A61K 31/353 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101)
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10772849 — Methods of regulating cannabinoid receptor activity-related disorders and diseases

US 10772849	Wainer et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Irving W. Wainer (Washington, District of Columbia); Michel Bernier (Pikesville, Maryland); Rajib K. Paul (Baltimore, Maryland)
ABSTRACT	This disclosure concerns the discovery of the use of fenoterol analogues for regulating cannabinoid (CB) receptor activity-related disorders and disease, such as dysregulated CB receptors, including treating a disorder or disease, such as a glioblastoma, hepatocellular carcinoma, liver cancer, colon cancer, and/or lung cancer, which is associated with altered cannabinoid receptor activity. In one example, the method includes administering to a subject having or at risk of developing a disorder or disease regulated by CB receptor activity an effective amount of a fenoterol analogue to reduce one or more symptoms associated with the disorder or disease regulated by CB receptor activity.
FILED	Friday, October 11, 2019
APPL NO	16/600234
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 45/06 (20130101)
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10772851 — Treatment and prevention of fungal infections

US 10772851	Neumann et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Aaron Kurt Neumann (Albuquerque, New Mexico); Harry Craig Pappas (Albuquerque, New Mexico); Matthew Graus (Albuquerque, New Mexico); David G. Whitten (Albuquerque, New Mexico); Kirk S. Schanze (Helotes, Texas); Rina Sylejmani (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Aaron Kurt Neumann (Albuquerque, New Mexico); Harry Craig Pappas (Albuquerque, New Mexico); Matthew Graus (Albuquerque, New Mexico); David G. Whitten (Albuquerque, New Mexico); Kirk S. Schanze (Helotes, Texas); Rina Sylejmani (Albuquerque, New Mexico)
ABSTRACT	Various embodiments disclosed relate to treatment of fungal infections. The present invention provides a method of treating a fungal infection including contacting a fungus including a β-glucan that is at least partially masked from immune system detection with a therapeutically effective amount of a compound that at least partially unmasks the β-glucan to increase immunogenicity of the fungus.
FILED	Thursday, February 01, 2018
APPL NO	15/886469
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/14 (20130101) Original (OR) Class A61K 31/75 (20130101) A61K 31/795 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101)
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10772858 — Benzhydrol derivatives for the management of conditions related to hypoxia inducible factors

US 10772858	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION (Atlanta, Georgia); Emory University (Atlanta, Georgia)
ASSIGNEE(S)	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Atlanta, Georgia); EMORY UNIVERSITY (Atlanta, Georgia)
INVENTOR(S)	Binghe Wang (Marietta, Georgia); Erwin Van Meir (Tucker, Georgia); Jalisa Holmes Ferguson (Chamblee, Georgia); Stefan Kaluz (Atlanta, Georgia); Xingyue Ji (Atlanta, Georgia)
ABSTRACT	This disclosure relates to benzhydrol derivatives for managing conditions related to the Hypoxia Inducible Factor (HIF) pathway such as uses in treating cancer. In certain embodiment, the disclosure contemplates compounds and pharmaceutical compositions. In certain embodiment, the disclosure contemplates compounds disclosed herein as prodrugs, optionally substituted with one or more substituents, derivatives, or salts thereof.
FILED	Monday, May 02, 2016
APPL NO	15/570969
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 31/04 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/09 (20130101) A61K 31/17 (20130101) A61K 31/17 (20130101) A61K 31/40 (20130101) A61K 31/085 (20130101) A61K 31/166 (20130101) A61K 31/166 (20130101) A61K 31/175 (20130101) A61K 31/175 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/341 (20130101) A61K 31/343 (20130101) A61K 31/351 (20130101) A61K 31/352 (20130101) A61K 31/357 (20130101) A61K 31/381 (20130101) A61K 31/397 (20130101) A61K 31/421 (20130101) A61K 31/435 (20130101) A61K 31/435 (20130101) A61K 31/436 (20130101) A61K 31/443 (20130101) A61K 31/444 (20130101) A61K 31/445 (20130101) A61K 31/475 (20130101) A61K 31/475 (20130101) A61K 31/495 (20130101) A61K 31/495 (20130101) A61K 31/536 (20130101) A61K 31/536 (20130101) A61K 31/538 (20130101) A61K 31/5375 (20130101) A61K 31/7068 (20130101) A61K 31/7068 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 43/295 (20130101) Heterocyclic Compounds C07D 205/04 (20130101) C07D 207/12 (20130101) C07D 211/46 (20130101) C07D 213/65 (20130101) C07D 263/32 (20130101) C07D 265/36 (20130101) C07D 295/096 (20130101) C07D 307/12 (20130101) C07D 307/20 (20130101) C07D 307/79 (20130101) C07D 309/10 (20130101) C07D 311/70 (20130101) C07D 319/16 (20130101) C07D 333/54 (20130101) C07D 405/12 (20130101) C07D 491/052 (20130101)
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10772862 — Lipid scavenging in Ras cancers

US 10772862	Rabinowitz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Memorial Sloan Kettering Cancer Center (New York, New York); The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S)	The Trustees of Princeton University (Princeton, New Jersey); Memorial Sloan Kettering Cancer Center (New York, New York)
INVENTOR(S)	Joshua Rabinowitz (Princeton, New Jersey); Jurre Kamphorst (Glasgow, United Kingdom); Craig Thompson (New York, New York); Justin Cross (New York, New York)
ABSTRACT	Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.
FILED	Monday, October 15, 2018
APPL NO	16/160237
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/10 (20160801) A23L 33/12 (20160801) A23L 33/17 (20160801) A23L 33/115 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2002/00 (20130101) A23V 2200/308 (20130101) A23V 2250/18 (20130101) A23V 2250/186 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/20 (20130101) Original (OR) Class A61K 31/66 (20130101) A61K 31/202 (20130101) A61K 31/202 (20130101) A61K 31/685 (20130101) A61K 36/889 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5748 (20130101) G01N 2500/10 (20130101) G01N 2800/52 (20130101)
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10772897 — Method for on-demand contraception

US 10772897	Ulmann et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	Laboratoire HRA-Pharma (Paris, France); The USA, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	Laboratoire HRA-Pharma (Paris, France); The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Andre Ulmann (Paris, France); Erin Gainer (Chardonne, Switzerland); Henri Camille Mathe (Paris, France); Diana Blithe (Silver Spring, Maryland); Lynnette Nieman (Bethesda, Maryland)
ABSTRACT	The invention relates to a method for on-demand contraception, which method comprises administering a progestogen agent or progesterone receptor modulator, such as 17a-acetoxy-11b-[4-N, N-dimethylamino-phenyl)-19-norpregna-4, 9-diene-3, 20-dione (ulipristal acetate) in a woman, within 72 hours before an intercourse or within 120 hours after the intercourse.
FILED	Friday, December 21, 2018
APPL NO	16/230802
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/20 (20130101) A61K 9/0036 (20130101) A61K 9/48 (20130101) A61K 9/2004 (20130101) A61K 31/56 (20130101) A61K 31/57 (20130101) A61K 31/573 (20130101) Original (OR) Class
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10772903 — Targeting fungi in combination with cancer therapy

US 10772903	Shiao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Cedars-Sinai Medical Center (Los Angeles, California)
ASSIGNEE(S)	Cedars-Sinai Medical Center (Los Angeles, California)
INVENTOR(S)	Stephen Shiao (Los Angeles, California); David Underhill (Tarzana, California)
ABSTRACT	Described herein are methods for the treatment of cancer by modulating fungal populations to enhance the therapeutic response to a cancer therapy. In particular, the present invention discloses modulating the fungal microbiome in combination with a cancer therapy to enhance the anti-tumor effect.
FILED	Tuesday, September 12, 2017
APPL NO	15/702141
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/513 (20130101) A61K 31/513 (20130101) A61K 31/4196 (20130101) A61K 31/4196 (20130101) A61K 31/7048 (20130101) Original (OR) Class A61K 31/7048 (20130101) A61K 36/06 (20130101) A61K 36/06 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) A61P 35/00 (20180101)
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10772913 — Administration of kynurenine depleting enzymes for tumor therapy

US 10772913	Georgiou et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	George Georgiou (Austin, Texas); Everett Stone (Austin, Texas)
ABSTRACT	Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
FILED	Tuesday, April 02, 2019
APPL NO	16/373588
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 38/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) Enzymes C12Y 307/01003 (20130101)
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10772914 — EBV-specific immune cells

US 10772914	Rooney et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Baylor College of Medicine (Houston, Texas)
ASSIGNEE(S)	Baylor College of Medicine (Houston, Texas)
INVENTOR(S)	Cliona M. Rooney (Bellaire, Texas); Sandhya Sharma (Houston, Texas)
ABSTRACT	Methods for generating/expanding populations of immune cells comprising immune cells specific for an Epstein Barr Virus (EBV) lytic antigen are disclosed, the methods comprising stimulating immune cells specific for an EBV lytic antigen by contacting peripheral blood mononuclear cells (PBMCs) with: (i) one or more peptides corresponding to all or part of one or more EBV lytic antigens; or (ii) antigen presenting cells (APCs) presenting one or more peptides corresponding to all or part of one or more EBV lytic antigens. Also disclosed are populations of immune cells comprising immune cells specific for an EBV lytic antigen expanded according to such methods, and uses thereof.
FILED	Thursday, April 18, 2019
APPL NO	16/388776
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/05 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101)
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10772918 — Probiotic prevention and treatment of colon cancer

US 10772918	Mazmanian et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Sarkis K. Mazmanian (Porter Ranch, California); Yunkyung Lee (Los Angeles, California)
ABSTRACT	Methods are provided herein for preventing, delaying the onset of or reducing the progression of colorectal tumorigenesis in a subject identified as at risk of colorectal tumorigenesis, comprising adjusting the composition of gut microbiota in the subject via administering to the subject a composition comprising Bacteroides bacteria or administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising zwitterionic polysaccharide (ZPS). In another aspect, methods are provided for treating or ameliorating a colorectal cancer in a subject, comprising adjusting the composition of gut microbiota in the subject having the colorectal cancer. In a further aspect, methods are provided for relieving gastrointestinal (GI) distress of a subject having a colorectal condition, comprising: determining the colorectal condition of the subject; and relieving GI distress in the subject by adjusting the composition of gut microbiota in the subject.
FILED	Wednesday, July 17, 2019
APPL NO	16/514796
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/59 (20130101) A61K 31/59 (20130101) A61K 31/715 (20130101) A61K 31/715 (20130101) A61K 35/741 (20130101) Original (OR) Class A61K 35/741 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10772931 — Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction

US 10772931	Panitch et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Alyssa Panitch (Davis, California); Rebecca Scott (West Lafayette, Indiana)
ABSTRACT	Compositions and methods are provided for treating a patient suffering from a disease associated with endothelial dysfunction by administering to the patient a pharmaceutical composition containing an effective amount of a synthetic collagen binding peptidoglycan.
FILED	Friday, April 24, 2015
APPL NO	15/306656
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/14 (20130101) A61K 38/16 (20130101) Original (OR) Class A61K 38/1709 (20130101) A61K 45/06 (20130101) A61K 47/61 (20170801)
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10772940 — Cocaine hydrolase-FC fusion proteins for cocaine and methods for utilizing the same

US 10772940	Zhan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
INVENTOR(S)	Chang-Guo Zhan (Lexington, Kentucky); Fang Zheng (Lexington, Kentucky); Hsin-Hsiung Tai (Lexington, Kentucky); Xiabin Chen (Lexington, Kentucky); Liu Xue (Lexington, Kentucky); Shurong Hou (Lexington, Kentucky)
ABSTRACT	The presently-disclosed subject matter includes isolated polypeptides that comprise a butyrylcholinestrase (BChE) polypeptide and a second polypeptide. The BChE polypeptide as well as the second polypeptide can be variants and/or fragments thereof. The presently-disclosed subject matter also includes a pharmaceutical composition that comprises the present isolated polypeptide and a suitable pharmaceutical carrier. Further still, methods are provided for treating cocaine-induced conditions, and comprise administering the isolated polypeptide and/or pharmaceutical compositions thereof to an individual.
FILED	Wednesday, December 11, 2013
APPL NO	14/102977
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) C12N 9/18 (20130101)
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10772949 — Dengue virus glycoprotein E DIII variants and uses thereof

US 10772949	Lai et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York)
ASSIGNEE(S)	Albert Einstein College of Medicine (Bronx, New York)
INVENTOR(S)	Jonathan R. Lai (Dobbs Ferry, New York); Margaret C. Kielian (Dobbs Ferry, New York); Julia C. Frei (Bronx, New York)
ABSTRACT	Specific Dengue virus glycoprotein subunit E DIII variants and their uses in preventing and treating Dengue virus infection are disclosed.
FILED	Monday, February 13, 2017
APPL NO	16/064505
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/55566 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24122 (20130101) C12N 2770/24134 (20130101) Technologies for Adaptation to Climate Change Y02A 50/386 (20180101)
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10772952 — Antiviral vaccines with improved cellular immunogenicity

US 10772952	Barouch et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Dan H. Barouch (Boston, Massachusetts); Bette T. Korber (Los Alamos, New Mexico); William M. Fischer (Los Alamos, New Mexico)
ABSTRACT	The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
FILED	Friday, June 14, 2019
APPL NO	16/441703
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 39/235 (20130101) A61K 39/275 (20130101) A61K 2039/53 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10043 (20130101) C12N 2710/10343 (20130101) C12N 2710/24043 (20130101) C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) C12N 2740/16171 (20130101) C12N 2740/16222 (20130101) C12N 2740/16234 (20130101) C12N 2740/16271 (20130101) C12N 2740/16322 (20130101) C12N 2740/16334 (20130101) Technologies for Adaptation to Climate Change Y02A 50/467 (20180101)
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10772966 — Compositions and methods for transport across the blood brain barrier

US 10772966	Walz
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	OPHIDION INC. (Bethlehem, Pennsylvania)
ASSIGNEE(S)	OPHIDION INC. (Bethlehem, Pennsylvania)
INVENTOR(S)	Andreas Walz (Bethlehem, Pennsylvania)
ABSTRACT	Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx1 protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier.
FILED	Monday, June 24, 2019
APPL NO	16/450831
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/713 (20130101) A61K 31/7088 (20130101) A61K 45/06 (20130101) A61K 47/42 (20130101) A61K 47/56 (20170801) A61K 47/64 (20170801) Original (OR) Class A61K 48/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 7/08 (20130101) C07K 14/00 (20130101) C07K 14/4703 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/3513 (20130101) C12N 2320/32 (20130101)
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10772967 — Enhanced anticancer agent

US 10772967	Alhamadsheh et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Mamoun M Alhamadsheh (Stockton, California)
ASSIGNEE(S)	Mamoun M. Alhamadsheh (Stockton, California)
INVENTOR(S)	Mamoun M. Alhamadsheh (Stockton, California); Miki S. Park (Stockton, California); William K. Chan (Elk Grove, California); Xiaoling Li (Dublin, California); Sravan C. Penchala (Stockton, California); Mark R. Miller (Stockton, California)
ABSTRACT	The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.
FILED	Friday, February 07, 2020
APPL NO	16/784971
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/4745 (20130101) A61K 38/00 (20130101) A61K 47/64 (20170801) Original (OR) Class A61K 47/545 (20170801) A61K 49/0052 (20130101) Heterocyclic Compounds C07D 231/12 (20130101)
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10772974 — Compositions and methods for cardiac regeneration

US 10772974	Rosenzweig et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) National Heart, Lung, and Blood Institute (NHLBI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Anthony Rosenzweig (Newton, Massachusetts); Vassilios J. Bezzerides (Brookline, Massachusetts)
ABSTRACT	The invention relates to the use of a CITED4 polypeptide and/or a microRNA-222 or precursor (e.g., pre-miR-222) or mimic thereof, for treating a cardiovascular disease or pathological condition, such as heart failure, myocardial infarction, and for promoting post-myocardial infarction cardiac remodeling in heart tissue.
FILED	Tuesday, November 18, 2014
APPL NO	15/037195
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0058 (20130101) A61K 48/0075 (20130101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/00041 (20130101) C12N 2710/10343 (20130101) C12N 2750/14143 (20130101) C12N 2830/006 (20130101) C12N 2830/008 (20130101)
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10772987 — Mineral coated scaffolds

US 10772987	Jongpaiboonkit et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Tissue Regeneration Systems, Inc. (Seattle, Washington)
ASSIGNEE(S)	TRS Holdings LLC (Ann Arbor, Michigan)
INVENTOR(S)	Leenaporn Jongpaiboonkit (Madison, Wisconsin); William L. Murphy (Madison, Wisconsin)
ABSTRACT	Provided is a composition for a scaffold having a mineral coating similar to bone. Also provided is a method for mineral coating a scaffold so as to promote mineral coating of the scaffold with a plate-like nanostructure and a carbonate-substituted, calcium-deficient hydroxyapatite phase.
FILED	Tuesday, March 03, 2015
APPL NO	14/637345
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/4455 (20130101) A61F 2002/2817 (20130101) A61F 2002/3008 (20130101) A61F 2002/3092 (20130101) A61F 2002/4485 (20130101) A61F 2002/30011 (20130101) A61F 2002/30032 (20130101) A61F 2002/30056 (20130101) A61F 2002/30062 (20130101) A61F 2002/30064 (20130101) A61F 2002/30303 (20130101) A61F 2002/30578 (20130101) A61F 2002/30785 (20130101) A61F 2002/30789 (20130101) A61F 2002/30838 (20130101) A61F 2002/30878 (20130101) A61F 2002/30884 (20130101) A61F 2002/30892 (20130101) A61F 2002/30899 (20130101) A61F 2210/0004 (20130101) A61F 2310/00017 (20130101) A61F 2310/00023 (20130101) A61F 2310/00029 (20130101) A61F 2310/00089 (20130101) A61F 2310/0097 (20130101) A61F 2310/00113 (20130101) A61F 2310/00131 (20130101) A61F 2310/00149 (20130101) A61F 2310/00155 (20130101) A61F 2310/00293 (20130101) A61F 2310/00796 (20130101) A61F 2310/00976 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/30 (20130101) A61K 38/1825 (20130101) A61K 38/1841 (20130101) A61K 38/1858 (20130101) A61K 38/1875 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/32 (20130101) Original (OR) Class A61L 27/56 (20130101) A61L 2400/18 (20130101) A61L 2420/02 (20130101) A61L 2420/06 (20130101) A61L 2430/02 (20130101) A61L 2430/38 (20130101)
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10773010 — Subcutaneous vascular access ports and related systems and methods

US 10773010	Phillips et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Advent Access Pte. Ltd. (Singapore, Singapore)
ASSIGNEE(S)	Advent Access Pte. Ltd. (Singapore, Singapore)
INVENTOR(S)	Christopher M. Phillips (Salt Lake City, Utah); Nathaniel P. Young (Salt Lake City, Utah); Trent J. Perry (Kaysville, Utah); Duane D. Blatter (Salt Lake City, Utah); Mark A. Crawford (Sandy, Utah); G. Doug Smith (Sandy, Utah); Steven Johnson (Lehi, Utah)
ABSTRACT	Ports for accessing a vessels within a patient include passageways that can guide needles or other access devices directly into the vessels. The ports can be implanted subcutaneously within a patient. Some ports may be used in the creation and use of vascular access buttonholes.
FILED	Friday, March 16, 2018
APPL NO	15/923854
ART UNIT	3781 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/0057 (20130101) A61B 17/3423 (20130101) A61B 2017/00641 (20130101) A61B 2017/00654 (20130101) A61B 2017/3425 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/3653 (20130101) Original (OR) Class A61M 1/3659 (20140204) A61M 1/3661 (20140204) A61M 39/0208 (20130101) A61M 2039/0223 (20130101) A61M 2039/0226 (20130101) A61M 2039/0238 (20130101) A61M 2205/0238 (20130101)
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10773074 — Multi-electrode array for spinal cord epidural stimulation

US 10773074	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Wentai Liu (Los Angeles, California); Victor Reggie Edgerton (Los Angeles, California); Chih-Wei Chang (Los Angeles, California); Parag Gad (Woodland Hills, California)
ABSTRACT	In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.
FILED	Thursday, August 27, 2015
APPL NO	15/506696
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0476 (20130101) A61N 1/0551 (20130101) A61N 1/0553 (20130101) Original (OR) Class A61N 1/0558 (20130101) A61N 1/3611 (20130101) A61N 1/36007 (20130101) A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 1/36082 (20130101) A61N 1/36107 (20130101) A61N 1/36114 (20130101)
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10773217 — Polyacid-functionalized porous membranes, related methods, and related polyacid polymers

US 10773217	Bruening et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan)
ASSIGNEE(S)	BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan)
INVENTOR(S)	Merlin L. Bruening (East Lansing, Michigan); Salinda Wijeratne (East Lansing, Michigan); Wenjing Ning (East Lansing, Michigan); Jinlan Dong (East Lansing, Michigan); Weijing Liu (East Lansing, Michigan)
ABSTRACT	The disclosure relates to processes, related polyacid polymers, and related articles for functionalizing a porous membrane by contacting the membrane with a polyacid polymer at low pH to stably adsorb a polyacid layer on the membrane pore surface, in particular polyacid polymers including repeating units with a pendent metal-binding ligand or star polyacid polymers. The resulting functionalized membrane is characterized by a high density of free acid groups, resulting in a higher specific capacity for its intended application. The process allows functionalization of porous membranes in a very simple, one-step process, for example without a need to derivatize an adsorbed polyacid layer to impart metal-binding ligand functionality thereto. Such functional membranes may find multiple uses, including rapid, selective binding of proteins for their purification or immobilization.
FILED	Wednesday, November 04, 2015
APPL NO	15/524483
ART UNIT	1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 67/0088 (20130101) B01D 67/0093 (20130101) B01D 69/02 (20130101) B01D 69/141 (20130101) B01D 69/142 (20130101) Original (OR) Class B01D 69/144 (20130101) B01D 71/38 (20130101) B01D 71/40 (20130101) B01D 71/60 (20130101) B01D 71/64 (20130101) B01D 71/82 (20130101) Compositions of Macromolecular Compounds C08L 73/02 (20130101) C08L 77/02 (20130101)
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10773238 — Enrichment of lysophosphatidic acids with templated polymeric materials

US 10773238	Strongin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Portland State University (Portland, Oregon)
ASSIGNEE(S)	Portland State University (Portland, Oregon)
INVENTOR(S)	Robert M. Strongin (Portland, Oregon); Martha Sibrian-Vazquez (Portland, Oregon); Jialu Wang (Portland, Oregon); Jorge O. Escobedo-Cordova (Portland, Oregon)
ABSTRACT	Embodiments of templated polymeric materials capable of binding lysophosphatidic acids (LPAs) are disclosed. Methods of making and using the templated polymeric materials also are disclosed. The disclosed templated polymeric materials are molecularly imprinted polymers that bind LPAs and facilitate the production of lysophosphatidic acid-enriched samples, for instance through extraction of lysophosphatidic acids from biological samples, such as plasma or serum samples.
FILED	Tuesday, February 23, 2016
APPL NO	15/553947
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 15/325 (20130101) B01D 15/426 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/268 (20130101) Original (OR) Class B01J 20/281 (20130101) B01J 20/285 (20130101) B01J 20/3057 (20130101) B01J 2220/54 (20130101) B01J 2220/62 (20130101) B01J 2220/4812 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/44 (20130101) C08F 22/22 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) G01N 33/92 (20130101) G01N 33/545 (20130101) G01N 2030/009 (20130101) G01N 2030/062 (20130101) G01N 2405/04 (20130101) G01N 2600/00 (20130101)
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10774046 — Inhibitors for the treatment of cancer and related methods

US 10774046	Telang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky)
ASSIGNEE(S)	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky)
INVENTOR(S)	Sucheta Telang (Louisville, Kentucky); Jason Chesney (Louisville, Kentucky); John O. Trent (Louisville, Kentucky); Joseph A. Burlison (Louisville, Kentucky); Nagaraju Miriyala (Louisville, Kentucky)
ABSTRACT	Some embodiments of the invention include inventive compounds. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as cancer). Further embodiments include methods for making the inventive compounds. Other embodiments include PFKFB4 inhibitors and methods of using the same that can target neoplastic cells, including, such as, mechanisms within those cells that relate to the use of the glycolytic pathway. In other embodiments, small molecule PFKFB4 inhibitors are used to disrupt the kinase domain of PFKFB4 and, in some instances, decrease the glucose metabolism and growth of human cancers. Additional embodiments of the invention are also discussed herein.
FILED	Thursday, October 25, 2018
APPL NO	16/170391
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4706 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 215/42 (20130101) C07D 215/46 (20130101) Original (OR) Class
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10774047 — Dimeric quinacrine derivatives as autophagy inhibitors for cancer therapy

US 10774047	Amaravadi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Ravi K. Amaravadi (Media, Pennsylvania); Jeffrey Winkler (Wynnewood, Pennsylvania)
ABSTRACT	The invention provides dimeric quinacrine derivatives and related compounds and compositions, methods of treatment and syntheses. The novel compounds exhibit unexpected anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.
FILED	Tuesday, April 26, 2016
APPL NO	15/567187
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/473 (20130101) A61K 31/473 (20130101) A61K 31/7068 (20130101) A61K 31/7068 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101) A61P 19/02 (20180101) A61P 33/06 (20180101) A61P 35/00 (20180101) A61P 35/04 (20180101) A61P 37/00 (20180101) Heterocyclic Compounds C07D 219/12 (20130101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 50/411 (20180101)
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10774049 — PU.1 inhibitors

US 10774049	Wilson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Albert Einstein College of Medicine (Bronx, New York); Georgia State University Research Foundation, Inc. (Atlanta, Georgia)
ASSIGNEE(S)	Albert Einstein College of Medicine (Bronx, New York); Georgia State University Research Foundation, Inc. (Atlanta, Georgia)
INVENTOR(S)	W. David Wilson (Atlanta, Georgia); David W. Boykin (Atlanta, Georgia); Gregory Poon (Lawrenceville, Georgia); Ulrich Steidl (New Rochelle, New York); Iléana Anthony-Debré (Paris, France)
ABSTRACT	Disclosed herein are inhibitors of PU.1. The inhibitors are useful for treating disorders associated with abnormal PU.1 levels and function.
FILED	Thursday, December 20, 2018
APPL NO	16/227739
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Heterocyclic Compounds C07D 209/12 (20130101) C07D 235/18 (20130101) C07D 235/20 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 409/04 (20130101) C07D 421/14 (20130101)
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10774063 — Materials and method for inhibiting replication protein A and uses thereof

US 10774063	Turchi
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana)
ASSIGNEE(S)	Indiana University Research and Technology Corporation (Indianapolis, Indiana)
INVENTOR(S)	John J. Turchi (Indianapolis, Indiana)
ABSTRACT	Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication Protein A, the eukaryotic single-strand (ss) DNA binding protein, is essential for genomic maintenance and stability via roles in both DNA replication and repair. Reported herein are small molecules that inhibit the in vitro, in vivo, and cellular ssDNA binding activity of RPA, thereby disrupting the eukaryotic cell cycle, inducing cytotoxicity and increasing the efficacy of chemotherapeutic agents damage DNA, and/or disrupt its replication and/or function. These results provide new insights into the mechanism of RPA-ssDNA interactions in chromosome maintenance and stability. This represents a molecularly targeted eukaryotic DNA binding inhibitor and demonstrates the utility of targeting a protein-DNA interaction as a means of studying the cell cycle and providing a therapeutic strategy for cancer treatment.
FILED	Friday, November 13, 2015
APPL NO	15/524830
ART UNIT	1699 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 45/06 (20130101) A61K 47/26 (20130101) A61K 47/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 231/06 (20130101) C07D 401/04 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 413/14 (20130101)
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10774090 — Pyrimidine compounds and pyrimido indole compounds and methods of use

US 10774090	Gangjee
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Duquesne University of the Holy Spirit (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	Duquesne University of the Holy Spirit (Pittsburgh, Pennsylvania)
INVENTOR(S)	Aleem Gangjee (Allison Park, Pennsylvania)
ABSTRACT	The present invention discloses a compound comprising the formula: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the S is replaced by CH₂or O, and optionally comprising a pharmaceutically acceptable salt or hydrate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt or hydrate thereof.
FILED	Tuesday, January 22, 2019
APPL NO	16/253751
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/343 (20130101) A61K 31/505 (20130101) A61K 31/4709 (20130101) Heterocyclic Compounds C07D 239/48 (20130101) C07D 403/02 (20130101) C07D 405/02 (20130101) C07D 487/04 (20130101) C07D 495/04 (20130101) Original (OR) Class
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10774092 — ULK1 inhibitors and methods using same

US 10774092	Shaw et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California); SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California); YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)	SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California); SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California); YALE UNIVERSITY (New Haven, Connecticut)
INVENTOR(S)	Reuben J. Shaw (La Jolla, California); Daniel F. Egan (La Jolla, California); Nicholas Cosford (La Jolla, California); Benjamin Turk (New Haven, Connecticut); Mitchell Vamos (La Jolla, California); Dhanya Raveendra Panickar (La Jolla, California); Matthew Chun (La Jolla, California); Douglas Sheffler (La Jolla, California)
ABSTRACT	In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
FILED	Friday, April 19, 2019
APPL NO	16/389784
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/505 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/506 (20130101) A61K 31/5377 (20130101) A61K 31/5383 (20130101) A61K 31/5383 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 239/34 (20130101) C07D 239/42 (20130101) C07D 239/47 (20130101) C07D 239/48 (20130101) C07D 239/557 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 413/14 (20130101) C07D 417/04 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) C07D 471/04 (20130101) C07D 498/04 (20130101) Original (OR) Class Peptides C07K 7/08 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Enzymes C12Y 207/11001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/912 (20130101) G01N 2500/04 (20130101) G01N 2500/20 (20130101) G01N 2800/52 (20130101)
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10774099 — Phospholipidation of imidazoquinolines and oxoadenines

US 10774099	Bazin-Lee et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	GLAXOSMITHKLINE BIOLOGICALS, SA (Rixensart, Belgium)
ASSIGNEE(S)	GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium)
INVENTOR(S)	Helene G. Bazin-Lee (Hamilton, Montana); Laura S. Bess (Hamilton, Montana); David A. Johnson (Hamilton, North Carolina)
ABSTRACT	The present invention relates to a process for phospholipidation of imidazoquinolines and oxoadenines. More particularly, the present invention relates to a high-yielding and scalable procedure for the phospholipidation of imidazoquinolines and oxoadenines which obviates the need to isolate unstable phosphoramidite intermediates. This process may be used for the phospholipidation of toll-like receptor 7 (TLR7)—active and toll-like receptor (TLR8)—active imidazoquinolines and oxoadenines.
FILED	Monday, December 12, 2016
APPL NO	16/060142
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/10 (20130101) C07F 9/65583 (20130101) Original (OR) Class C07F 9/65616 (20130101)
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10774110 — Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof

US 10774110	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Jun Liu (Baltimore, Maryland); Jingxin Wang (Baltimore, Maryland); Zhaoli Sun (Baltimore, Maryland); Sam Hong (Baltimore, Maryland)
ABSTRACT	A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.
FILED	Friday, February 03, 2017
APPL NO	16/073746
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 47/545 (20170801) Heterocyclic Compounds C07D 498/18 (20130101) C07D 519/00 (20130101) Peptides C07K 5/1008 (20130101) Original (OR) Class
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10774112 — Biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases

US 10774112	Popel et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
INVENTOR(S)	Aleksander S. Popel (Lutherville-Timonium, Maryland); Niranjan B. Pandey (White Marsh, Maryland); Esak Lee (Windsor Mill, Maryland); Jordan J. Green (Nottingham, Maryland); Ron B. Shmueli (Baltimore, Maryland)
ABSTRACT	Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, an isolated peptide comprising the amino acid sequence LRRFSTAPFAFIDINDVINF, which exhibits anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models is disclosed. The isolate peptide also exhibits anti-lymphangiogenic and directly anti-tumorigenic properties.
FILED	Friday, September 22, 2017
APPL NO	15/712890
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) A61K 45/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 7/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) C12N 2510/00 (20130101)
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10774118 — Peptides having reduced toxicity that stimulate cholesterol efflux

US 10774118	Bielicki et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	John K. Bielicki (San Ramon, California); Jan Johansson (San Ramon, California); Waleed Danho (Del Mar, California)
ABSTRACT	The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer's Disease or frontotemporal dementia.
FILED	Wednesday, June 27, 2018
APPL NO	16/020395
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/17 (20130101) A61K 45/06 (20130101) A61K 47/64 (20170801) A61K 47/544 (20170801) Peptides C07K 14/435 (20130101) Original (OR) Class C07K 14/775 (20130101)
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10774121 — Methods and compositions for treating neurodegenerative disorders and Alzheimer's Disease and improving normal memory

US 10774121	Dewji et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Nazneen Dewji (San Diego, California); S. Jonathan Singer (La Jolla, California)
ABSTRACT	The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and progression of Alzheimer's disease.
FILED	Thursday, February 21, 2019
APPL NO	16/282263
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/1709 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/4711 (20130101) Original (OR) Class
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10774122 — ERG targeted therapy

US 10774122	Chinnaiyan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Arul Chinnaiyan (Plymouth, Michigan); Xiaoju Wang (Ann Arbor, Michigan)
ABSTRACT	The present disclosure relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present disclosure relates to recurrent gene fusions as clinical targets for cancer.
FILED	Monday, March 19, 2018
APPL NO	15/924377
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) A61K 9/127 (20130101) A61K 38/00 (20130101) A61K 47/60 (20170801) A61K 47/64 (20170801) A61K 47/542 (20170801) Peptides C07K 14/47 (20130101) C07K 14/82 (20130101) C07K 14/4705 (20130101) C07K 14/4748 (20130101) Original (OR) Class C07K 2319/01 (20130101) C07K 2319/02 (20130101) C07K 2319/09 (20130101) C07K 2319/10 (20130101) C07K 2319/33 (20130101) C07K 2319/61 (20130101)
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10774131 — Mimetic peptides derived from collagen type IV and their use for treating angiogenesis- and lymphangiogenesis-dependent diseases

US 10774131	Popel et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
INVENTOR(S)	Aleksander S. Popel (Lutherville, Maryland); Elena V. Rosca (Baltimore, Maryland); Jacob E. Koskimaki (Baltimore, Maryland); Corban G. Rivera (Baltimore, Maryland); Niranjan B. Pandey (White Marsh, Maryland); Amir P. Tamiz (Silver Spring, Maryland)
ABSTRACT	Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumori-genic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed. The presently disclosed mimetic peptides also exhibit anti-lymphangiogenic and directly anti-tumorigenic properties.
FILED	Friday, September 14, 2018
APPL NO	16/131754
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/78 (20130101) Original (OR) Class
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10774132 — Ultralong complementarity determining regions and uses thereof

US 10774132	Smider et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
ASSIGNEE(S)	THE SCRIPPS RESEARCH INSTITTUE (La Jolla, California)
INVENTOR(S)	Vaughn Smider (San Diego, California); Omar A. Bazirgan (San Diego, California); Hongyuan Helen Mao (San Diego, California); Peter Schultz (La Jolla, California); Feng Wang (Encinitas, California); Yong Zhang (San Diego, California)
ABSTRACT	Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.
FILED	Wednesday, January 09, 2013
APPL NO	13/737910
ART UNIT	1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/53 (20130101) C07K 16/10 (20130101) Original (OR) Class C07K 16/46 (20130101) C07K 2317/50 (20130101) C07K 2317/569 (20130101) C07K 2318/00 (20130101) C07K 2319/30 (20130101)
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10774134 — Conserved hemagglutinin epitope, antibodies to the epitope, and methods of use

US 10774134	Marasco et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Burnham Institute for Medical Research (La Jolla, California)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Burnham Institute for Medical Research (La Jolla, California)
INVENTOR(S)	Wayne A. Marasco (Wellesley, Massachusetts); Jianhua Sui (Boston, Massachusetts); Robert C. Liddington (La Jolla, California)
ABSTRACT	Disclosed are antibodies that bind to the stem region of influenza hemagglutinin in the neutral pH conformation, hemagglutinin epitopes to the stem region, and methods of making and using both.
FILED	Wednesday, June 20, 2018
APPL NO	16/013085
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/005 (20130101) C07K 16/1018 (20130101) Original (OR) Class C07K 2299/00 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/16022 (20130101) C12N 2760/16034 (20130101)
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10774135 — Variant antibodies that bind AIP2

US 10774135	Zhang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Sorrento Therapeutics, Inc. (San Diego, California)
ASSIGNEE(S)	Sorrento Therapeutics, Inc. (San Diego, California)
INVENTOR(S)	Yanliang Zhang (San Diego, California); Gunnar F. Kaufmann (San Diego, California)
ABSTRACT	The present disclosure provides fully human variant anti-AIP2 variant antibodies, and antigen binding proteins thereof, having improved characteristics compared to the wild type anti-AIP2 antibody E7 from which the variant clones are derived. The variant anti-AIP2 antibodies exhibit improved binding to AIP1 and AIP4 as determined in an in vitro quorum sensing reporter assay, have improved thermal stability, provided complete protection against infection with two different strains of Staphylococcus aureus MRSA in pre-treated mice, and can be manufactured at higher yields.
FILED	Thursday, December 20, 2018
APPL NO	16/228570
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/1271 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/55 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) C07K 2317/567 (20130101) C07K 2317/622 (20130101)
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10774143 — Modulation of T cell signaling via slat association with IP3R1

US 10774143	Altman
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (La Jolla, California)
ASSIGNEE(S)	LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (La Jolla, California)
INVENTOR(S)	Amnon Altman (La Jolla, California)
ABSTRACT	Methods of modulating immune responses are provided, including contacting SLAT or IP3R1 with an agent that modulates binding of SLAT to IP3R1. Methods of modulating activation or differentiation of CD4+ T cells are also provided, including contacting SLAT or IP3R1 with an agent that modulates binding of SLAT to IP3R1. Peptides and fragments of an IP3R1 amino acid sequence that binds to a SLAT amino acid sequence, and peptides and fragments of a SLAT amino acid sequence that binds to am IP3R1 amino acid sequence, are further provided.
FILED	Friday, May 01, 2015
APPL NO	14/702059
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/17 (20130101) A61K 38/177 (20130101) A61K 2300/00 (20130101) Peptides C07K 14/705 (20130101) C07K 16/18 (20130101) C07K 16/28 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101)
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10774149 — Composition comprised of antigen linked to a TNF superfamily ligand

US 10774149	Stone et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Geoffrey W. Stone (San Francisco, California); Richard S. Kornbluth (La Jolla, California)
ASSIGNEE(S)	UNIVERSITY OF MIAMI (Miami, Florida)
INVENTOR(S)	Geoffrey W. Stone (San Francisco, California); Richard S. Kornbluth (La Jolla, California)
ABSTRACT	The invention provides fusion proteins comprising antigens of infectious disease agents and cancer cells linked to multiple-trimer forms of TNF SuperFamily (TNFSF) ligands. The TNFSFs serve as vaccine adjuvants for increasing the immune response to the antigens. In particular, a fusion polypeptide strand that self-assembles inside cells into a multiple-trimer form of CD40 ligand (CD40L, TNFSF5) is provided. Other similar fusion proteins are also disclosed. The fusion proteins can be delivered to a host as isolated proteins, as nucleic acids used directly in DNA vaccination or carried and expressed by a viral vector such as adenovirus. In addition to use as a vaccine to prevent or ameliorate disease caused by an infectious agent, compositions of the invention may be used for the treatment of ongoing infection or for cancer immunotherapy.
FILED	Thursday, August 02, 2018
APPL NO	16/053767
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/00 (20130101) A61K 39/0011 (20130101) A61K 39/21 (20130101) A61K 2039/53 (20130101) A61K 2039/572 (20130101) A61K 2039/645 (20130101) A61K 2039/5154 (20130101) A61K 2039/55516 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 35/00 (20180101) Peptides C07K 14/005 (20130101) C07K 14/705 (20130101) C07K 14/785 (20130101) C07K 14/70575 (20130101) C07K 16/2878 (20130101) Original (OR) Class C07K 2317/622 (20130101) C07K 2319/30 (20130101) C07K 2319/33 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16034 (20130101) C12N 2740/16234 (20130101)
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10774326 — Compositions and methods for manipulation of adipocyte energy consumption regulatory pathway

US 10774326	Kellis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); EUROPEAN MOLECULAR BIOLOGY LABORATORY (Heidelberg, Germany)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); EUROPEAN MOLECULAR BIOLOGY LABORATORY (Heidelberg, Germany)
INVENTOR(S)	Manolis Kellis (Brookline, Massachusetts); Melina Christine Claussnitzer (Somerville, Massachusetts); Jan Korbel (Heidelberg, Germany)
ABSTRACT	Provided herein is a pathway for adipocyte energy consumption regulation involving ARID5B, genetic variant rs1421085, IRX3, and IRX5. Compositions and methods for modulating the pathway in vitro and in vivo for anti-cachectic and anti-obesity effects are provided. Methods of identifying subjects at risk of developing a disorder mediated by a dysregulation of the energy consumption pathway are also provided.
FILED	Wednesday, December 23, 2015
APPL NO	15/539621
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/141 (20130101) C12N 2800/80 (20130101)
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10774327 — Oligonucleotide compounds for targeting huntingtin mRNA

US 10774327	Khvorova et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
ASSIGNEE(S)	UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
INVENTOR(S)	Anastasia Khvorova (Westborough, Massachusetts); Neil Aronin (Newtonville, Massachusetts); Julia Alterman (Worcester, Massachusetts)
ABSTRACT	This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
FILED	Thursday, January 31, 2019
APPL NO	16/263200
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0085 (20130101) A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/52 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/343 (20130101) C12N 2310/344 (20130101) C12N 2310/346 (20130101) C12N 2310/3515 (20130101) C12N 2310/3517 (20130101) C12N 2310/3519 (20130101) C12N 2310/3521 (20130101) C12N 2310/3533 (20130101) C12N 2320/11 (20130101) C12N 2320/30 (20130101) C12N 2320/32 (20130101) C12N 2320/51 (20130101)
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10774328 — Treatment for glaucoma and other eye diseases

US 10774328	Zode
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	University of North Texas Health Science Center at Fort Worth (Fort Worth, Texas)
ASSIGNEE(S)	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (Fort Worth, Texas)
INVENTOR(S)	Gulab Zode (Fort Worth, Texas)
ABSTRACT	The present invention includes a composition and method for the treatment of an eye disease comprising a therapeutically effective amount of an autophagy stimulator that treats or slows the progression of the eye disease by enhancing or stimulating autophagy or correcting an autophagy deficiency.
FILED	Tuesday, July 11, 2017
APPL NO	16/317473
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/436 (20130101) A61K 31/4745 (20130101) A61K 31/5377 (20130101) A61K 38/1709 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/111 (20130101) C12N 2310/141 (20130101) C12N 2320/10 (20130101)
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10774334 — Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety

US 10774334	Curtiss, III et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Dental and Craniofacial Research (NIDCR) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	The Arizona Board of Regents for and on Behalf of Arizona State University (Scottsdale, Arizona); The Washington University (St. Louis, Missouri)
ASSIGNEE(S)	Arizona Broad of Regents on Behalf of Arizona State University (Scottsdale, Arizona); The Washington University (St. Louis, Missouri)
INVENTOR(S)	Roy Curtiss, III (Gainesville, Florida); Shifeng Wang (Gainesville, Florida); Soo-Young Wanda (Gainesville, Florida); Wei Kong (Phoenix, Arizona)
ABSTRACT	The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
FILED	Thursday, December 05, 2019
APPL NO	16/704032
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 39/00 (20130101) A61K 2035/11 (20130101) A61K 2039/522 (20130101) A61K 2039/523 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/36 (20130101) C12N 15/74 (20130101) Original (OR) Class
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10774372 — Methods and systems for determining spatial patterns of biological targets in a sample

US 10774372	Chee et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Prognosys Biosciences, Inc. (San Diego, California)
ASSIGNEE(S)	Prognosy s Biosciences, Inc. (San Diego, California)
INVENTOR(S)	Mark S. Chee (San Diego, California); David A. Routenberg (San Diego, California)
ABSTRACT	The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.
FILED	Tuesday, October 08, 2019
APPL NO	16/596200
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) Original (OR) Class C12Q 1/6809 (20130101) C12Q 2565/513 (20130101) C12Q 2565/629 (20130101)
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10774373 — Compositions comprising glucosylated hydroxymethylated bases

US 10774373	Rao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
INVENTOR(S)	Anjana Rao (La Jolla, California); Mamta Tahiliani (New York, New York); Kian Peng Koh (Jamaica Plain, Massachusetts); Suneet Agarwal (Belmont, Massachusetts); Aravind Iyer (Bethesda, Massachusetts)
ABSTRACT	The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
FILED	Thursday, August 15, 2019
APPL NO	16/541857
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2501/70 (20130101) C12N 2501/71 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/26 (20130101) C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) Original (OR) Class C12Q 1/6827 (20130101) C12Q 1/6869 (20130101) C12Q 2521/531 (20130101) C12Q 2521/531 (20130101) C12Q 2522/10 (20130101) C12Q 2522/10 (20130101) C12Q 2537/164 (20130101) C12Q 2537/164 (20130101) C12Q 2600/154 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101)
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10774389 — Alternative splice variant patterns of human telomerase reverse transcriptase (hTERT) in thyroid tumors to distinguish benign from malignant

US 10774389	Zeiger et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Martha Allen Zeiger (Bethesda, Maryland); Jeanne Kowalski (Baltimore, Maryland); Christopher Umbricht (Towson, Maryland); Yongchun Wang (Towson, Maryland)
ABSTRACT	This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of TERT (telomerase reverse transcriptase) mRNA which lacks the β sequence and the amount of TERT mRNA in the sample which comprises the β sequence, wherein a preponderance (e.g., at least about 55%) of TERT mRNA in the sample which comprises the β sequence indicates that the tumor is malignant, and wherein a preponderance of TERT mRNA which lacks the β sequence indicates that the tumor is not malignant.
FILED	Friday, September 29, 2017
APPL NO	15/719815
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101)
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10774390 — Methods and compositions for modulating PrfA mediated virulence gene activation in Listeria spp

US 10774390	Portnoy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Daniel A. Portnoy (Albany, California); Jonathan L. Portman (Berkeley, California)
ABSTRACT	Methods of assessing expression of a PrfA mediated expression construct in a Listerial host cell are provided. Aspects of the methods include maintaining a Listerial host cell that includes a PrfA mediated expression construct in a defined medium containing a reducing agent and evaluating expression of a product from the expression construct to assess expression of the PrfA mediated expression construct. Also provided are methods of producing and using a Listerial vaccine, as well as defined media for use in such methods.
FILED	Thursday, September 01, 2016
APPL NO	15/754288
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 39/0208 (20130101) A61K 2039/521 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/74 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/158 (20130101)
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10774392 — Compositions and methods for identifying secretory antibody-bound microbes

US 10774392	Flavell et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	Yale University (New Haven, Connecticut)
INVENTOR(S)	Richard Flavell (Guilford, Connecticut); Noah Palm (New Haven, Connecticut); Marcel de Zoete (New Haven, Connecticut)
ABSTRACT	The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression of inflammatory diseases and disorders. Thus, the invention relates to compositions and methods for detecting and identifying the constituents of a subject's microbiota, methods of modifying the constituents of the microbiota, and methods for treating inflammatory diseases and disorders in a subject in need thereof.
FILED	Wednesday, August 14, 2019
APPL NO	16/540408
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 39/0208 (20130101) A61K 2035/115 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6806 (20130101) C12Q 2537/159 (20130101) C12Q 2563/131 (20130101) C12Q 2565/113 (20130101)
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10775322 — Inert crystal delivery medium for serial femtosecond crystallography

US 10775322	Conrad et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Chelsie Conrad (Phoenix, Arizona); Petra Fromme (Mesa, Arizona); Daniel James (Mesa, Arizona); Christopher Kupitz (Scottsdale, Arizona)
ABSTRACT	A system and method for preparing a crystal delivery medium comprising agarose for serial femtosecond crystallography and uses thereof.
FILED	Wednesday, June 15, 2016
APPL NO	15/183149
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/14 (20130101) C30B 29/58 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/2005 (20130101) Original (OR) Class G01N 33/483 (20130101)
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10775366 — Substrates for detection of botulinum neurotoxin

US 10775366	Kalkum et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	CITY OF HOPE (Duarte, California)
ASSIGNEE(S)	CITY OF HOPE (Duarte, California)
INVENTOR(S)	Markus Kalkum (Azusa, California); Karine Bagramyan (North Hollywood, California)
ABSTRACT	Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin. This assay is designed to capture a low number of toxin molecules and to measure their intrinsic protease activity via conversion of a fluorogenic or luminescent substrate. Also provided herein are novel peptides that can be specifically cleaved by BoNT and novel peptides that are resistant to cleavage by BoNT. The combination of these cleavable and control peptides can be used for implementation of an exemplary ALISSA used to specifically detect BoNT enzymatic activity. Furthermore, the ALISSA as described herein may also be used in a column based format for use in a high-throughput system for testing large quantities of samples.
FILED	Monday, February 06, 2017
APPL NO	15/425923
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 7/08 (20130101) C07K 14/705 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/569 (20130101) G01N 33/573 (20130101) G01N 33/5306 (20130101) G01N 33/5308 (20130101) Original (OR) Class G01N 2333/32 (20130101) G01N 2333/33 (20130101) G01N 2333/38 (20130101) G01N 2333/90241 (20130101)
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10775391 — Nervous system-specific transmembrane proteasome complex that modulates neuronal signaling through extracellular signaling via brain activity peptides

US 10775391	Margolis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH) National Science Foundation (NSF)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Seth S. Margolis (Towson, Maryland); Kapil V. Ramachandran (Baltimore, Maryland)
ABSTRACT	The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural-specific and membrane bound proteasome (neuronal membrane proteasome or NMP) that is transmembrane in nature. These secreted, activity-induced, proteasomal peptides (SNAPPs) range in size from about 500 Daltons to about 3000 Daltons. Surprisingly none of the peptides appear to be those previously known to have any neuronal function. Moreover, these SNAPPs have stimulatory activity and are heretofore a new class of signaling molecules. Moreover, the NMP appears to play a highly significant role in aspects of neuronal signaling known to be critical for neuronal function. The inventors have gone on to develop all tools to study this novel mechanisms including protocols and practice for generation and purification of SNAPPs as well as a new and specific inhibitor of the NMP allowing for selective control of this process in the nervous system. The present invention provides methods of making and using these SNAPPs for both laboratory and clinical purposes, the screening for molecules which modulate NMP function in vivo and in vitro, and methods for diagnosis of NMP related diseases.
FILED	Thursday, February 11, 2016
APPL NO	15/550632
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 31/165 (20130101) A61K 38/05 (20130101) A61K 51/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/72 (20130101) G01N 33/5023 (20130101) G01N 33/5058 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2030/8831 (20130101) G01N 2333/47 (20130101) G01N 2800/2821 (20130101)
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10775450 — Zero field parametric resonance magnetometer with triaxial sensitivity

US 10775450	Shah et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	QuSpin, Inc. (Louiville, Colorado)
ASSIGNEE(S)	Quspin, Inc. (Louisville, Colorado)
INVENTOR(S)	Vishal Shah (Superior, Colorado); Cody Doyle (Broomfield, Colorado); James Osborne (Erie, Colorado)
ABSTRACT	This disclosure relates to the field of zero-field paramagnetic resonance magnetometer (ZF-PRM). A sensitive ZF-PRM capable of measuring magnetic field in three orthogonal directions simultaneously and method of measuring magnetic field in three orthogonal directions is described. The ZF-PRM provides three independent output signals proportional to the three orthogonal vector components of the magnetic field using a single vapor cell, thus reducing complexity and cost of the magnetometer. Because all three magnetic components are measured at substantially the same location at the same time, the accuracy of data is greatly increased.
FILED	Saturday, March 28, 2020
APPL NO	16/833576
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) G01R 33/032 (20130101) G01R 33/0206 (20130101) Original (OR) Class G01R 33/1284 (20130101) Optical Elements, Systems, or Apparatus G02B 27/283 (20130101)
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10775452 — Magnetic particle imaging

US 10775452	Goodwill
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	Magnetic Insight, Inc. (Alameda, California); University of California at Berkeley (Berkeley, California)
ASSIGNEE(S)	MAGNETIC INSIGHT, INC. (Alameda, California); UNIVERSITY OF CALIFORNIA AT BERKELEY (Berkely, California)
INVENTOR(S)	Patrick W. Goodwill (Oakland, California)
ABSTRACT	A Magnetic Particle Imaging (MPI) system with a magnet configured to generate a magnetic field having a field free line, the system including at least one shim magnet configured to modify the magnetic field in a manner to maintain desired magnetic flux distributions during imaging.
FILED	Wednesday, July 12, 2017
APPL NO	15/648403
ART UNIT	2896 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0515 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/72 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/10 (20130101) G01R 33/0213 (20130101) G01R 33/1276 (20130101) Original (OR) Class
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10775462 — System and method for direct saturation-corrected chemical exchange saturation transfer (DISC-CEST)

US 10775462	Sun et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Phillip Zhe Sun (Woburn, Massachusetts); Iris Yuwen Zhou (Winthrop, Massachusetts)
ABSTRACT	A system and method is provided that includes acquiring chemical exchange saturation transfer (CEST) data with the MRI system and generating an acquired Z-spectrum (Z) from the CEST data. The system and method also includes computing an estimated direct water saturation (Z′) based using at least one of relaxation measurements derived from the CEST data or imaging parameters used to acquire the CEST data with the MRI system, computing a direct saturation corrected Z-spectrum (ΔZ) using the acquired Z-spectrum (Z) and the estimated direct water saturation (Z′), and generating a CEST image of the subject using the direct saturation corrected Z-spectrum (ΔZ).
FILED	Thursday, July 05, 2018
APPL NO	16/027895
ART UNIT	2868 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/485 (20130101) G01R 33/4838 (20130101) Original (OR) Class G01R 33/5605 (20130101) G01R 33/5608 (20130101)
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10775463 — Method for estimating T2

US 10775463	Hargreaves et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
INVENTOR(S)	Brian A. Hargreaves (Menlo Park, California); Bragi Sveinsson (Stanford, California)
ABSTRACT	A method for providing an estimated 3D T₂map for magnetic resonance imaging using a Double-Echo Steady-State (DESS) sequence for a volume of an object in a magnetic resonance imaging (MRI) system is provided. A DESS scan of the volume is provided by the MRI system. Signals S₁and S₂are acquired by the MRI system. Signals S₁and S₂are used to provide a T₂map for a plurality of slices of the volume, comprising determining repetition time (TR), echo time (TE), flip angle α, and an estimate of the longitudinal relaxation time (T₁), and wherein the DESS scan has a spoiler gradient with an amplitude G and a duration τ and ignoring echo pathways having spent more than two repetition times in the transverse plane.
FILED	Friday, April 07, 2017
APPL NO	15/482351
ART UNIT	2868 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) Original (OR) Class G01R 33/4816 (20130101) G01R 33/4835 (20130101)
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10775464 — System and method for dynamic, cardiac phase-resolved quantitative longitudinal relaxation parameter mapping

US 10775464	Weingartner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Sebastian Weingartner (Minneapolis, Minnesota); Mehmet Akcakaya (Minneapolis, Minnesota)
ABSTRACT	Systems and methods for producing quantitative maps of a longitudinal relaxation parameter, such as a longitudinal relaxation time (“T1”), using magnetic resonance imaging (“MRI”) are described. More particularly, a pulse sequence and imaging method for cardiac phase-resolved myocardial T1 mapping are provided.
FILED	Wednesday, January 31, 2018
APPL NO	15/885158
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0044 (20130101) A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/246 (20130101) G01R 33/4828 (20130101) G01R 33/5601 (20130101) G01R 33/5602 (20130101) Original (OR) Class G01R 33/5613 (20130101) G01R 33/5673 (20130101) G01R 33/56509 (20130101)
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10776516 — Electronic medical record datasifter

US 10776516	Dinov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Nursing Research (NINR) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	The Regents of The University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Ivaylo Dinov (Ann Arbor, Michigan); John Vandervest (Ann Arbor, Michigan); Simeone Marino (Ann Arbor, Michigan)
ABSTRACT	A method is presented for generating a data set from a database. The method involves iterative data manipulation that stochastically identifies candidate entries from the cases (subjects, participants) and variables (data elements) and subsequently selects, nullifies, and imputes the information. This process heavily relies on statistical multivariate imputation to preserve the joint distributions of the complex structured data archive. At each step, the algorithm generates a complete dataset that in aggregate closely resembles the intrinsic characteristics of the original data set, however, on an individual level the rows of data are substantially altered. This procedure drastically reduces the risk for subject reidentification by stratification, as meta-data for all subjects is repeatedly and lossily encoded.
FILED	Wednesday, August 01, 2018
APPL NO	16/051881
ART UNIT	2165 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/2272 (20190101) G06F 17/11 (20130101) G06F 17/18 (20130101) G06F 21/6254 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/003 (20130101) G06N 7/005 (20130101) G06N 7/08 (20130101) G06N 20/20 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/70 (20180101)
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10776606 — Methods for delineating cellular regions and classifying regions of histopathology and microanatomy

US 10776606	Parvin et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Bahram Parvin (Mill Valley, California); Hang Chang (Moraga, California); Yin Zhou (Newark, Delaware)
ABSTRACT	Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.
FILED	Monday, September 22, 2014
APPL NO	14/493208
ART UNIT	2663 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00147 (20130101) Original (OR) Class G06K 9/6249 (20130101) G06K 9/6255 (20130101)
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10776607 — Predicting prostate cancer biochemical recurrence and metastasis with computer extracted features from tumor nuclei and benign regions

US 10776607	Madabhushi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Center for Research Resources (NCRR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Anant Madabhushi (Shaker Heights, Ohio); Anna Gawlik (St. Charles, Illinois); George Lee (Parlin, New Jersey)
ABSTRACT	Embodiments predict biochemical recurrence (BCR) or metastasis by accessing a set of images of a region of tissue demonstrating cancerous pathology, including a tumor region and a tumor adjacent benign (TAB) region, the set of images including a first stain type image, and a second stain type image; segmenting cellular nuclei represented in the first and second image; generating a combined feature set by extracting at least one feature from each of a tumor region and TAB region represented in the first image, and a tumor region and TAB region represented in the second image, providing the combined feature set to a machine learning classifier; receiving, from the classifier, a probability that the region of tissue will experience BCR or metastasis; and generating a classification of the region of tissue as likely to experience BCR or metastasis, or unlikely to experience BCR or metastasis.
FILED	Friday, May 18, 2018
APPL NO	15/983397
ART UNIT	2649 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1475 (20130101) G01N 33/57434 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00134 (20130101) G06K 9/00147 (20130101) Original (OR) Class G06K 9/627 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0014 (20130101) G06T 7/60 (20130101) G06T 2207/10024 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30081 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/30 (20180101) G16H 50/50 (20180101)
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10776608 — Systems, methods, and apparatus for in vitro single-cell identification and recovery

US 10776608	Adalsteinsson et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Viktor A. Adalsteinsson (Wakefield, Massachusetts); Denis Loginov (Dorchester Center, Massachusetts); J. Christopher Love (Somerville, Massachusetts); Alan Stockdale (Providence, Rhode Island); Todd Gierahn (Brookline, Massachusetts)
ABSTRACT	Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
FILED	Monday, August 13, 2018
APPL NO	16/102118
ART UNIT	2485 — Recording and Compression
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 2300/12 (20130101) B01L 2300/0654 (20130101) B01L 2300/0829 (20130101) B01L 2300/0851 (20130101) B01L 2300/0896 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1425 (20130101) G01N 15/1463 (20130101) G01N 33/4833 (20130101) G01N 35/00029 (20130101) G01N 35/00871 (20130101) G01N 2015/0065 (20130101) G01N 2015/1006 (20130101) G01N 2035/00148 (20130101) Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/26 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/036 (20130101) G06K 9/00147 (20130101) Original (OR) Class G06K 9/4647 (20130101) G06K 9/4652 (20130101) G06K 9/4661 (20130101) Pictorial Communication, e.g Television H04N 5/2256 (20130101)
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10776935 — System and method for correcting data for deformations during image-guided procedures

US 10776935	Miga et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee)
INVENTOR(S)	Michael I. Miga (Franklin, Tennessee); Prashanth Dumpuri (Kirkland, Washington)
ABSTRACT	Systems and methods for collecting and processing physical space data for use while performing an image-guided surgical (IGS) procedure are provided. The system and method includes obtaining a computer model of a non-rigid structure of interest in a patient and performing a rigid alignment of the computer model and surface data in a patient space associated with at least a portion of the non-rigid structure. The system and method also include computing a deformation of the computer model that provides a non-rigid alignment of the computer model and surface data, the deformation computed using a set of boundary conditions defined for each node of the computer model based on the rigid alignment and a kernel function. Additionally, the system and method can include displaying data for facilitating the IGS procedure based on the deformation.
FILED	Monday, September 18, 2017
APPL NO	15/707516
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/00 (20130101) Analogue Computers G06G 7/60 (20130101) Image Data Processing or Generation, in General G06T 7/33 (20170101) Original (OR) Class
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10777298 — Analyzing immune signaling networks for identification of therapeutic targets in complex chronic medical disorders

US 10777298	Fletcher et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	NOVA SOUTHEASTERN UNIVERSITY (Fort Lauderdale, Florida); UNIVERSITY OF MIAMI (Miami, Florida); UNIVERSITY OF ALBERTA, TEC EDMONTON (Edmonton, Alberta, California)
ASSIGNEE(S)	Nova Southeastern University (Fort Lauderdale, Florida); University of Miami (Miami, Florida); University of Alberta, TEC Edmonton (Edmonton, California)
INVENTOR(S)	Mary Ann Fletcher (Miami, Florida); Gordon Broderick (Edmonton, Alberta, California); Nancy Klimas (Fort Lauderdale, Florida); Zachary Barnes (Miami, Florida)
ABSTRACT	A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3−/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin-15 (IL-15).
FILED	Tuesday, October 14, 2014
APPL NO	15/028757
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/2086 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class G16B 40/00 (20190201)
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10777299 — Systems and methods for matching oncology signatures

US 10777299	Califano et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Andrea Califano (New York, New York); Mariano Javier Alvarez (Cortlandt Manor, New York)
ABSTRACT	Techniques to profile a disease or a disorder (e.g., a tumor) based on a protein activity signature are disclosed herein. An example method can include measuring quantitatively protein activity of a plurality of master regulator proteins in a sample from a disease or disorder; and profiling the tumor from the quantitative protein activity of the master regulator proteins. Also disclosed are methods of identifying a compound or compounds that treats diseases or disorders (e.g., inhibit tumor cell growth).
FILED	Friday, August 26, 2016
APPL NO	15/249069
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/57484 (20130101) G01N 2500/20 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class
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10777402 — Systems and methods for quantifying an analyte extracted from a sample

US 10777402	Ouyang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Zheng Ouyang (West Lafayette, Indiana); Yue Ren (West Lafayette, Indiana); Ziqing Lin (West Lafayette, Indiana)
ABSTRACT	The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.
FILED	Tuesday, March 05, 2019
APPL NO	16/293017
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/167 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 436/24 (20150115) Y10T 436/255 (20150115)
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Department of Defense (DOD)

10772272 — Algae cultivation systems and methods with reduced energy loss

US 10772272	Hazlebeck
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Global Algae Innovations, Inc. (San Diego, California)
ASSIGNEE(S)	Global Algae Technologies, LLC (Santee, California)
INVENTOR(S)	David A. Hazlebeck (El Cajon, California)
ABSTRACT	An open raceway algae cultivation system includes a channel configured to contain an algae cultivation fluid. The channel includes a contraction zone having a width and a depth. A pump is configured to circulate the algae cultivation fluid in the channel. A width of the contraction zone decreases leading into the entrance of the pump and a depth of the contraction zone is greater than a depth of at least a portion of the channel located outside of the contraction zone.
FILED	Tuesday, May 09, 2017
APPL NO	15/590441
ART UNIT	3643 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 33/00 (20130101) Original (OR) Class New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 4/00 (20130101) A01H 13/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/02 (20130101) C12M 23/18 (20130101) C12M 23/38 (20130101) C12M 31/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Technologies for Adaptation to Climate Change Y02A 40/88 (20180101)
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10772504 — Apparatus, systems and methods for intraoperative imaging

US 10772504	Anwar et al.
FUNDED BY	Department of Defense (DOD) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	Regents of the University of California (San Francisco, California)
ASSIGNEE(S)	The Regents of the University of California (San Francisco, California)
INVENTOR(S)	Moshiur M. Anwar (San Francisco, California); Catherine Park (San Francisco, California); Bernard Boser (Berkeley, California)
ABSTRACT	The disclosed apparatus, systems and methods relate to devices, systems and methods for intra-operative imaging.
FILED	Friday, August 25, 2017
APPL NO	15/687205
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Original (OR) Class A61B 5/0084 (20130101) A61B 5/0091 (20130101) A61B 5/4381 (20130101) A61B 5/4836 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0058 (20130101) A61K 49/0067 (20130101)
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10772742 — Polycentric powered ankle prosthesis

US 10772742	Lenzi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR)
APPLICANT(S)	REHABILITATION INSTITUTE OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)	Rehabilitation Institute of Chicago (Chicago, Illinois)
INVENTOR(S)	Tommaso Lenzi (Chicago, Illinois); Marco Cempini (Chicago, Illinois); Todd Kuiken (Chicago, Illinois)
ABSTRACT	Systems and methods are disclosed for a powered ankle prosthesis. The prosthesis may comprise a polycentric mechanism having a defined path for an instantaneous center of rotation. The path of the instantaneous center of rotation may be defined by a trajectory substantially equal to an arc positioned over a joint of the polycentric mechanism.
FILED	Friday, April 07, 2017
APPL NO	15/482663
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/70 (20130101) A61F 2/6607 (20130101) Original (OR) Class A61F 2002/701 (20130101) A61F 2002/5018 (20130101) A61F 2002/5021 (20130101) A61F 2002/5027 (20130101) A61F 2002/5038 (20130101) A61F 2002/6614 (20130101) A61F 2002/6836 (20130101) A61F 2002/7635 (20130101)
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10773114 — Zirconium hydroxide-based slurry for decontamination and detoxification

US 10773114	Myers et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Aberdeen Proving Ground (APG) Combat Capabilities Development Command (CCDC) Chemical Biological Center (CCDC CBC) Research, Development and Engineering Command (RDECOM) Edgewood Chemical Biological Center (ECBC)
APPLICANT(S)	U.S. Army Edgewood Chemical Biological Center (APG, Maryland)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Joseph P Myers (Havre de Grace, Maryland); Lawrence R Procell (Elkton, Maryland); Felicia Levine (Bel Air, Maryland)
ABSTRACT	The present invention is directed towards a composition for decontaminating surfaces contaminated with toxic chemicals/substances, comprising at least one type of metal oxyhydroxide such as zirconium hydroxide, Zr(OH)₄, optionally with added water for hydration of the solid, mixed into a carrier liquid used for application to a contaminated surface.
FILED	Monday, November 19, 2018
APPL NO	16/194957
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/30 (20130101) Original (OR) Class A62D 2101/02 (20130101) A62D 2101/26 (20130101) A62D 2101/28 (20130101)
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10773430 — Thermoplastic composite part manufacturing system and method

US 10773430	Steinacher et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Philip P. Steinacher (Carrollton, Illinois); Randall Dow Wilkerson (O'Fallon, Missouri); James Rodney Fox (University City, Missouri); Michael Palmore Matlack (St Charles, Missouri); Ryan Joseph Merriman (Ballwin, Missouri); Donald C. Besselsen (Lake St. Louis, Missouri); David Phillip Bruk (St. Louis, Missouri)
ABSTRACT	A method and apparatus for a continuous compression molding machine. The continuous compression molding machine comprises a tooling die, extending through a heating zone and a cooling zone, a tooling sleeve, and a biasing system. The tooling sleeve corresponds to the tooling die and is for use in forming a thermoplastic composite part from a thermoplastic composite charge when the tooling sleeve with the thermoplastic composite charge is moved with respect to the tooling die through the heating zone and the cooling zone. The biasing system is configured to hold the thermoplastic charge at a first angle within the heating zone and hold the thermoplastic composite charge at a second angle within the cooling zone, as the tooling sleeve moves through the heating zone and the cooling zone with the thermoplastic composite charge. The first angle is different from the second angle.
FILED	Tuesday, April 25, 2017
APPL NO	15/496302
ART UNIT	1748 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 43/28 (20130101) Original (OR) Class B29C 43/34 (20130101) B29C 43/44 (20130101) B29C 43/52 (20130101) B29C 70/50 (20130101) B29C 2043/522 (20130101) B29C 2043/527 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 99/0003 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2101/12 (20130101) B29K 2105/256 (20130101)
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10773819 — Fuel tank with water bladder

US 10773819	Haugstetter
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Hamilton Sundstrand Corporation (Charlotte, North Carolina)
ASSIGNEE(S)	HAMILTON SUNSTRAND CORPORATION (Charlotte, North Carolina)
INVENTOR(S)	Christoph Haugstetter (West Hartford, Connecticut)
ABSTRACT	A tank assembly is provided and includes a housing which has a housing volume and which is chargeable with a volume of a first fluid, a bladder disposed within the housing and chargeable with a second fluid such that the bladder has a minimal volume in an uncharged state and a flow system. The flow system includes a portion thereof which is coupled to the bladder and which has a second volume within the housing. The flow system is configured to at least charge the bladder with a volume of the second fluid which is equal to or less than a difference between the housing volume less a sum of the minimal volume and the second volume and the volume of the first fluid.
FILED	Monday, August 21, 2017
APPL NO	15/682183
ART UNIT	3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 11/02 (20130101) B60K 2015/0777 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 13/06 (20130101) B64D 33/08 (20130101) B64D 37/06 (20130101) Original (OR) Class B64D 37/10 (20130101) B64D 2013/0662 (20130101) B64D 2013/0674 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/1435 (20130101)
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10773821 — Energy absorbing composite panels

US 10773821	Bolukbasi et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Akif O. Bolukbasi (Mesa, Arizona); Timothy R. Gleason (Mesa, Arizona); Peter Holemans (Sewell, New Jersey)
ABSTRACT	Typical composite panels are brittle and unable to support transverse pressure loads that might be imposed on the panels. For example, the use of typical panels around fuel tanks of a vehicle are unable to support transverse pressure loads that might be imposed on the fuel tanks during a crash of the vehicle or a ballistic impact to the fuel tanks. In the embodiments described herein, panels include face sheets that are bonded to a foam core. The foam core includes a corrugated core sheet that is formed from a highly ductile material, such as Polyethylene or Aluminum. When a transverse pressure load is imposed on the panel, core crush of the foam occurs as the core sheet elongates from its original corrugated shape to a curve shape during deformation. This allows the panel to dissipate the energy of the transverse pressure load applied to the panel.
FILED	Tuesday, March 27, 2018
APPL NO	15/937414
ART UNIT	1782 — Miscellaneous Articles, Stock Material
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 1/02 (20130101) B32B 3/18 (20130101) B32B 3/28 (20130101) B32B 3/30 (20130101) B32B 5/18 (20130101) B32B 5/26 (20130101) B32B 5/145 (20130101) B32B 5/245 (20130101) B32B 7/022 (20190101) B32B 15/20 (20130101) B32B 15/046 (20130101) B32B 27/32 (20130101) B32B 27/065 (20130101) B32B 2250/40 (20130101) B32B 2260/023 (20130101) B32B 2260/046 (20130101) B32B 2262/106 (20130101) B32B 2266/06 (20130101) B32B 2266/08 (20130101) B32B 2305/022 (20130101) B32B 2307/56 (20130101) B32B 2307/558 (20130101) B32B 2439/40 (20130101) B32B 2605/18 (20130101) Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 15/03 (20130101) B60K 15/03177 (20130101) B60K 2015/0631 (20130101) B60K 2015/03407 (20130101) Indexing Scheme Relating to Aspects Cross-cutting Vehicle Technology B60Y 2200/50 (20130101) B60Y 2306/01 (20130101) Aeroplanes; Helicopters B64C 1/00 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 37/02 (20130101) B64D 37/32 (20130101) Original (OR) Class B64D 2037/325 (20130101)
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10774007 — Fast-densified ceramic matrix composite

US 10774007	Pope
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Edward J. A. Pope (Westlake Village, California)
ASSIGNEE(S)
INVENTOR(S)	Edward J. A. Pope (Westlake Village, California)
ABSTRACT	A densified ceramic matrix composite (CMC) material densified CMC exhibits superior strength and toughness, relative to prior CMCs The material can be made by a process that includes impregnating a set of ceramic fibers with a non-fibrous ceramic material, resulting in a precursor matrix, stabilizing the precursor matrix, resulting in a stabilized matrix, and densifying the stabilized matrix using a frequency assisted sintering technology (FAST) process, resulting in the densified CMC material.
FILED	Tuesday, November 14, 2017
APPL NO	15/813065
ART UNIT	1731 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/571 (20130101) C04B 35/573 (20130101) C04B 35/575 (20130101) C04B 35/645 (20130101) Original (OR) Class C04B 35/806 (20130101) C04B 35/6268 (20130101) C04B 35/62868 (20130101) C04B 35/62873 (20130101) C04B 2235/61 (20130101) C04B 2235/66 (20130101) C04B 2235/77 (20130101) C04B 2235/96 (20130101) C04B 2235/608 (20130101) C04B 2235/614 (20130101) C04B 2235/616 (20130101) C04B 2235/666 (20130101) C04B 2235/3826 (20130101) C04B 2235/5244 (20130101) C04B 2235/5445 (20130101) C04B 2235/6567 (20130101) C04B 2237/32 (20130101) C04B 2237/083 (20130101)
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10774092 — ULK1 inhibitors and methods using same

US 10774092	Shaw et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California); SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California); YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)	SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California); SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California); YALE UNIVERSITY (New Haven, Connecticut)
INVENTOR(S)	Reuben J. Shaw (La Jolla, California); Daniel F. Egan (La Jolla, California); Nicholas Cosford (La Jolla, California); Benjamin Turk (New Haven, Connecticut); Mitchell Vamos (La Jolla, California); Dhanya Raveendra Panickar (La Jolla, California); Matthew Chun (La Jolla, California); Douglas Sheffler (La Jolla, California)
ABSTRACT	In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
FILED	Friday, April 19, 2019
APPL NO	16/389784
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/505 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/506 (20130101) A61K 31/5377 (20130101) A61K 31/5383 (20130101) A61K 31/5383 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 239/34 (20130101) C07D 239/42 (20130101) C07D 239/47 (20130101) C07D 239/48 (20130101) C07D 239/557 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 413/14 (20130101) C07D 417/04 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) C07D 471/04 (20130101) C07D 498/04 (20130101) Original (OR) Class Peptides C07K 7/08 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Enzymes C12Y 207/11001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/912 (20130101) G01N 2500/04 (20130101) G01N 2500/20 (20130101) G01N 2800/52 (20130101)
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10774107 — DNA gridiron compositions and methods

US 10774107	Han et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S)	Dongran Han (Cambridge, Massachusetts); Hao Yan (Chandler, Arizona)
ABSTRACT	Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
FILED	Wednesday, November 28, 2018
APPL NO	16/202841
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 21/04 (20130101) Original (OR) Class
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10774220 — Inorganic passive coatings for atomic vapor cells

US 10774220	Roper et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Christopher S. Roper (Oak Park, California); Adam F. Gross (Santa Monica, California)
ABSTRACT	Some variations provide an atomic vapor-cell system comprising: a vapor-cell region configured with vapor-cell walls for containing an atomic vapor; and a coating disposed on at least some interior surfaces of the walls, wherein the coating comprises magnesium oxide, a rare earth metal oxide, or a combination thereof. The atomic vapor-cell system may be configured to allow at least one optical path through the vapor-cell region. In some embodiments, the coating comprises or consists essentially of magnesium oxide and/or a rare earth metal oxide. When the coating contains a rare earth metal oxide, it may be a lanthanoid oxide, such as lanthanum oxide. The atomic vapor-cell system preferably further comprises a device to adjust vapor pressure of the atomic vapor within the vapor-cell region. Preferably, the device is a solid-state electrochemical device configured to convey the atomic vapor into or out of the vapor-cell region.
FILED	Monday, October 29, 2018
APPL NO	16/173316
ART UNIT	2849 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3103 (20130101) Time-interval Measuring G04F 5/14 (20130101)
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10774304 — System and method for production of on-demand proteins in a portable unit for point of care delivery

US 10774304	Rao et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON)
APPLICANT(S)	UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland)
ASSIGNEE(S)	UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland)
INVENTOR(S)	Govind Rao (Ellicott City, Maryland); Yordan Kostov (Columbia, Maryland); Leah Tolosa (Columbia, Maryland); Xudong Ge (Woodstock, Maryland); Douglas Frey (Ellicott City, Maryland); Shayan Gholipour Borhani (Glen Arm, Maryland); David Burgenson (Ellicott City, Maryland)
ABSTRACT	A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
FILED	Wednesday, October 23, 2019
APPL NO	16/660993
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 41/12 (20130101) C12M 47/10 (20130101) Original (OR) Class C12M 47/12 (20130101)
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10774655 — Gas turbine engine component with flow separating rib

US 10774655	Spangler et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Brandon W. Spangler (Vernon, Connecticut); Gina Cavallo (Watertown, Connecticut)
ABSTRACT	A component for a gas turbine engine according to an example of the present disclosure includes, among other things, a wall that extends about a cooling cavity. The cooling cavity is a dual-fed cavity that is fed from at least two different locations. A rib separates the cooling cavity into a first portion and a second portion that is fluidly isolated from the first portion. The component is an airfoil. The first portion is fed with a first cooling fluid from a first coolant source, and the second portion is fed with a second, different cooling fluid from a second coolant source. The first and second coolant sources are separate and distinct from the component.
FILED	Tuesday, March 13, 2018
APPL NO	15/919253
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/186 (20130101) F01D 5/187 (20130101) Original (OR) Class F01D 9/041 (20130101) F01D 9/065 (20130101) F01D 25/12 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/11 (20130101) F05D 2240/12 (20130101) F05D 2240/20 (20130101) F05D 2250/75 (20130101) F05D 2250/184 (20130101) F05D 2250/185 (20130101) F05D 2260/202 (20130101) F05D 2260/2212 (20130101) F05D 2260/22141 (20130101)
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10774662 — Separable turbine vane stage

US 10774662	Brown et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Rolls-Royce Corporation (Indianapolis, Indiana)
ASSIGNEE(S)	ROLLS-ROYCE CORPORATION (Indianapolis, Indiana)
INVENTOR(S)	Elise A. M. Brown (Indianapolis, Indiana); Emma L. Mitchell (Indianapolis, Indiana); Elyse M. McMillen (Indianapolis, Indiana); David L. Tondreau, III (Indianapolis, Indiana); Eric T. Koenig (Fishers, Indiana); Linnea L. Taketa (Indianapolis, Indiana)
ABSTRACT	A vane stage segment is provided including an outer wall segment, an inner wall segment, and an airfoil. The outer wall segment is configured to be coupled to other outer wall segments to form an outer wall of the vane stage. The inner wall segment is spaced radially inward from the outer wall segment. At least one of the inner wall segment or the outer wall segment is separable between a forward portion and an aft portion. The airfoil extends between the outer wall segment and the inner wall segment.
FILED	Tuesday, July 17, 2018
APPL NO	16/037580
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/042 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/321 (20130101) F05D 2220/323 (20130101) F05D 2230/60 (20130101) F05D 2240/12 (20130101) F05D 2300/174 (20130101) F05D 2300/175 (20130101)
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10774685 — Gas turbine engine exhaust component

US 10774685	Eastwood et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RATHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Jonathan Jeffery Eastwood (West Hartford, Connecticut); Adam Lee Hart (Stuart, Florida); Brian Craig (Palm Beach Gardens, Florida); Luis Miguel Ayalde (Weston, Florida); Brian Levy (Sunny Isles Beach, Florida)
ABSTRACT	A heat shield for a gas turbine engine includes a radial heat shield flange that extends in a circumferential direction and forms a ring. A plurality of bosses extend from a first axial side of the radial heat shield flange. There is a plurality of guide pins. One of the plurality of guide pins extends from a corresponding one of the plurality of bosses.
FILED	Monday, April 30, 2018
APPL NO	15/966760
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/04 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/04 (20130101) F01D 25/30 (20130101) F01D 25/243 (20130101) Original (OR) Class F01D 25/246 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) Jet-propulsion Plants F02K 1/40 (20130101) F02K 1/44 (20130101) F02K 1/52 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/76 (20130101) F05D 2220/323 (20130101) F05D 2240/15 (20130101)
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10774742 — Flared anti-vortex tube rotor insert

US 10774742	Giannakopoulos et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Life Cycle Management Center (AFLCMC)
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Konstantinos Panagiotis Giannakopoulos (Middletown, Connecticut); Erica J. Harvie (Middletown, Connecticut)
ABSTRACT	A compressor rotor includes a first disk and a conical section connected to the first disk. The conical section includes at least one flow hole. A bore cavity is defined between the conical section and the first disk. The bore cavity is arranged in fluid communication with the at least one flow hole. An anti-vortex tube is disposed within the at least one flow hole of the conical section and includes at least one feature arranged in contact with a surface of the conical section to restrict movement of the anti-vortex tube out of engagement with the conical section.
FILED	Wednesday, March 21, 2018
APPL NO	15/927659
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/082 (20130101) F01D 5/084 (20130101) F01D 5/088 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 6/08 (20130101) Original (OR) Class Non-positive-displacement Pumps F04D 29/321 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/20 (20130101) F05D 2250/232 (20130101) F05D 2260/36 (20130101) F05D 2260/201 (20130101)
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10775136 — Edge-on armor system with translating and rotating armor panels

US 10775136	Walker et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Southwest Research Institute (San Antonio, Texas)
ASSIGNEE(S)	Southwest Research Institute (San Antonio, Texas)
INVENTOR(S)	James D. Walker (San Antonio, Texas); Daniel J. Pomerening (San Antonio, Texas); Kristopher C. Kozak (San Antonio, Texas); Nicholas J. Mueschke (San Antonio, Texas); Isaias S. Chocron (San Antonio, Texas); Gregory N. Wattis (San Antonio, Texas); Jesse A. Beavers (Boerne, Texas); Oliver P. Harrison (San Antonio, Texas); Stephan J. Lemmer (Belleville, Michigan); Neal A. Seegmiller (Pittsburgh, Pennsylvania)
ABSTRACT	An armor system for protecting vehicles and other equipment against projectiles and similar threats. A track is mounted on the equipment, and an upper sled and lower sled are moveably attached to the track. An armor panel is pivotally attached to one sled and is pivotally attached with arms to the other sled. The two sleds are independently actuated along the track, such that their relative positions determine both the translational and rotational position of the armor panel. The armor panel can be quickly rotated from an undeployed position against the vehicle through a desired arc outward from the vehicle, which increases the edge-on or nearly edge-on presentation of the armor panel to the projectile.
FILED	Thursday, April 26, 2018
APPL NO	15/963881
ART UNIT	3612 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/007 (20130101) Original (OR) Class F41H 5/013 (20130101) F41H 7/04 (20130101)
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10775138 — Ready armor protection for instant deployment

US 10775138	Esquilin-Mangual et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	United States of America as Represented by The Secretary of The Army (Alexandria, Virginia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Alexandria, Virginia)
INVENTOR(S)	Omar Esquilin-Mangual (Vicksburg, Mississippi); Catherine S Stephens (Clinton, Mississippi); Omar G Flores (Vicksburg, Mississippi); Andrew B Edwards (Toney, Alabama); Erik M Chappell (Vicksburg, Mississippi); Carey D Price (Vicksburg, Mississippi)
ABSTRACT	Ready armor modular protective systems that can be rapidly deployed in an urban environment. Exemplary armor systems include multiple space frame units. Adjacent space frame units can be coupled together with vertically adjustable coupling mechanisms. Coupling mechanisms (e.g. slot and pin connecting mechanisms) can facilitate relative displacement between adjacent space frame units when the units are connected. In this way, a wall of connected adjacent space frame units can be placed and/or moved along an uneven or irregular surface (e.g. having bumps or a grade) and the adjacent space frame units can remain in parallel and/or vertical orientation relative to one another. Suspension mechanisms can help to facilitate or enable rapid deployment of a ready armor modular protective system.
FILED	Thursday, March 07, 2019
APPL NO	16/296149
ART UNIT	3635 — Static Structures, Supports and Furniture
CURRENT CPC	General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 1/3445 (20130101) E04B 1/34357 (20130101) Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General E04H 9/04 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/013 (20130101) Original (OR) Class
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10775141 — Exoskeleton cartridge case design for LW 30MM ammunition

US 10775141	Moy et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	U.S. Government as Represented by the Secretary of the Army (Picatinny Arsenal, Dover, New Jersey)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Leon Moy (Verona, New Jersey); Viral Panchal (Parlin, New Jersey); Pasquale Carlucci (Fairlawn, New Jersey)
ABSTRACT	An insensitive munition (IM) feature for a lightweight LW 30 MM ammunition projectile utilizing combustible vent plugs for the projectile, which plugs feature an exclusively nitrocellulose material sheet fused to a metal foil sheet, to plug vent holes in the projectile.
FILED	Friday, August 30, 2019
APPL NO	16/556699
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/207 (20130101) Original (OR) Class F42B 39/20 (20130101)
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10775279 — Passive sampling of airborne particles with the aid of natural air flow

US 10775279	Kesavan et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Aberdeen Proving Ground (APG) Combat Capabilities Development Command (CCDC) Chemical Biological Center (CCDC CBC) Research, Development and Engineering Command (RDECOM) Edgewood Chemical Biological Center (ECBC)
APPLICANT(S)	U.S. Army Edgewood Chemical Biological Center (APG, Maryland)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Jana S Kesavan (Catonsville, Maryland); Nathan Kesavan (Catonsville, Maryland); Jerold R Bottiger (Aberdeen, Maryland)
ABSTRACT	An apparatus for passive sampling of airborne particles such as those found in an aerosol is disclosed. The passive sampler is designed to take advantage of natural air flow to collect airborne particles, such as those contained in an aerosol, for subsequent analysis. The passive sampler increases the sampling efficiency for diffusion and electrostatic collection of particles by using natural airflow or movement to bring particles closer to the deposition surface. Alternately charged electret filters further increase the sampling efficiency.
FILED	Wednesday, March 14, 2018
APPL NO	15/921349
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2205 (20130101) Original (OR) Class G01N 1/2273 (20130101) G01N 2001/2223 (20130101) G01N 2001/2276 (20130101)
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10775337 — Potential gradient amplified detection of chemical agents

US 10775337	Braun et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Paul V. Braun (Champaign, Illinois); Mohammad Amdad Ali (Urbana, Illinois)
ABSTRACT	New approaches for selective detection of chemical agents such as sarin are necessary because of the high toxicity of sarin and related compounds, the potential of these compounds to be used as weapons of mass destruction, and the limitations of current detection methodologies. Herein is described an apparatus and a method for selective and amplified detection of sarin simulants deposited via an aerosol process. The simulant absorbs into a hydrogel, where it hydrolyzes upon contact with water producing elemental ions. The elemental ions are then concentrated via an ionic chemical potential gradient to a sensor, where it is detected. This technique has potential to amplify the capture efficiency of a sensor by a 1000-fold within couple of minutes.
FILED	Friday, January 26, 2018
APPL NO	15/880815
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Compositions of Macromolecular Compounds C08L 33/26 (20130101) C08L 2201/54 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) C12Q 1/44 (20130101) Enzymes C12Y 301/08002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 1/405 (20130101) G01N 1/4044 (20130101) G01N 27/333 (20130101) Original (OR) Class G01N 27/403 (20130101) G01N 27/44747 (20130101) G01N 33/0013 (20130101) G01N 33/0057 (20130101) G01N 33/559 (20130101) G01N 2333/916 (20130101) Technologies for Adaptation to Climate Change Y02A 50/25 (20180101)
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10775420 — Non-contact multi-phase cable sensor

US 10775420	Heintzelman et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Sean M. Heintzelman (Laurel, Maryland); Simon J. Ghionea (North Bend, Washington); David M. Hull (Adelphi, Maryland)
ABSTRACT	A system includes at least one electric field sensor and at least one magnetic field sensor, wherein the at least one electric field sensor and the at least one magnetic field sensor are formed as an integrated sensor unit with a single electrical circuit, and wherein the integrated sensor is configured to measure power of an energized cable.
FILED	Thursday, September 21, 2017
APPL NO	15/710894
ART UNIT	2868 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 21/08 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/181 (20130101) H05K 2201/10151 (20130101)
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10775451 — SQUID having integrated resistive element

US 10775451	Leese de Escobar et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	United States Government as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)	United States Government as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Anna Leese de Escobar (Encinitas, California); Robert Lewis Fagaly (Carlsbad, California); Susan Anne Elizabeth Berggren (San Diego, California); Benjamin Jeremy Taylor (Escondido, California); Marcio Calixto de Andrade (San Diego, California)
ABSTRACT	A superconducting quantum interference device (SQUID) for mobile magnetic sensing applications comprising: at least two Josephson junction electrically connected to a superconducting loop; and a resistive element connected in series with one of the Josephson junctions in the superconducting loop. The resistive element is disposed in the same superconducting loop as the at least two Josephson junctions.
FILED	Wednesday, September 12, 2018
APPL NO	16/129558
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0354 (20130101) Original (OR) Class
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10775459 — Optorelaxers for nuclear magnetic resonance spectroscopy

US 10775459	Yesinowski et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	James P. Yesinowski (Fort Washington, Maryland); Joel B. Miller (Cheverly, Maryland); Christopher A. Klug (Falls Church, Virginia)
ABSTRACT	The invention relates to compounds known as “optorelaxers,” for example, spin crossover (SCO) complexes that exhibit light-induced excited state spin trapping (LIESST) effects with transient unpaired electron spins, which are created (or destroyed) by varying the level and/or wavelength of light to which the complexes are exposed. Light conditions are used to switch the optorelaxers between transient paramagnetic and diamagnetic states to provide real-time control of T₁relaxation in nuclear magnetic resonance (NMR) spectroscopy methods. The optorelaxers and methods of the invention provide increased detection sensitivity of NMR spectroscopy, with increased structural information content, while maintaining resolution for a wide variety of different NMR-active nuclei.
FILED	Monday, July 23, 2018
APPL NO	16/043068
ART UNIT	2868 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/307 (20130101) G01R 33/448 (20130101) G01R 33/4608 (20130101) G01R 33/4641 (20130101) Original (OR) Class
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10775532 — Adaptive guided wind sonde

US 10775532	MacArthur et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Innovative Automation Technologies, LLC (Gainesville, Florida)
ASSIGNEE(S)	Innovative Automation Technologies, LLC (Gainesville, Florida)
INVENTOR(S)	Donald K. MacArthur (Gainesville, Florida); Erica Z. MacArthur (Gainesville, Florida)
ABSTRACT	An adaptive guided wind sonde (AGWS) includes a main body defining a longitudinal axis including a nose end and a tail end including a body that has main wings attached. Secondary wings are on the nose end. A measurement and control system inside the body includes a Global Positioning System (GPS) for providing position and velocity, and an Inertial Measurement Unit (IMU) is for providing inertial measurements. A wing driver is for adjusting a position of at least one of the secondary wings or control surfaces when included on the main wings. A Meteorological Sensor Suite (MSS) is for providing environmental data. An adaptive controller receives data including the position, the velocity, the inertial measurements, and the environmental data for generating wind calculations including a wind speed and a wind direction, and for providing autopilot for the AGWS. Wireless communications is for wirelessly transmitting the wind calculations.
FILED	Thursday, January 24, 2019
APPL NO	16/256007
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 1/08 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 5/02 (20130101) G01P 13/045 (20130101) Meteorology G01W 1/08 (20130101) Original (OR) Class
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10775572 — Low footprint optical interconnects

US 10775572	Veitch et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	Wavefront Research, Inc. (Bethlehem, Pennsylvania)
ASSIGNEE(S)	Wavefront Research, Inc. (Northhampton, Pennsylvania)
INVENTOR(S)	Randall C. Veitch (Nazareth, Pennsylvania); Thomas W. Stone (Hellertown, Pennsylvania)
ABSTRACT	Compact ASIC, chip-on-board, flip-chip, interposer, and related packaging techniques are incorporated to minimize the footprint of optoelectronic interconnect devices, including the Optical Data Pipe. In addition, ruggedized packaging techniques are incorporated to increase the durability and application space for optoelectronic interconnect devices, including an Optical Data Pipe.
FILED	Monday, May 07, 2018
APPL NO	15/972823
ART UNIT	2874 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/4212 (20130101) Original (OR) Class G02B 6/4239 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/02327 (20130101)
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10775648 — Systems and methods for implementing electrically tunable metasurfaces

US 10775648	Atwater
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Harry A. Atwater (South Pasadena, California)
ABSTRACT	Systems and methods in accordance with embodiments of the invention implement electrically tunable metasurfaces. In one embodiment, an electrically tunable metasurface reflectarray includes: a mirrored surface; a conductive layer; a dielectric layer; where the conductive layer and the dielectric layer are in direct contact, and thereby define a conductor-dielectric interface; a plurality of subwavelength antenna elements; and an electrical power source configured to establish a potential difference between at least one subwavelength antenna element and the mirrored surface; where a potential difference between a subwavelength antenna element and the mirrored surface applies an electric field to a corresponding region of the electrically tunable metasurface reflectarray; where any applied electric fields in conjunction with the geometry and the material composition of each of the subwavelength antenna elements, the conductive layer, and the dielectric layer, enable the electrically tunable metasurface reflectarray to measurably augment the propagation characteristics of incident electromagnetic waves.
FILED	Monday, April 30, 2018
APPL NO	15/967445
ART UNIT	2872 — Optics
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 26/02 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0018 (20130101) Original (OR) Class G02F 1/0121 (20130101) G02F 2202/30 (20130101)
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10775651 — Double-layer graphene optical modulators and methods of fabrication thereof

US 10775651	Dalir et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Multidisciplinary University Research Initiative (MURI) Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	Hamed Dalir (El Cerrito, California); Yang Xia (Albany, California); Yuan Wang (El Cerrito, California); Xiang Zhang (Alamo, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Hamed Dalir (El Cerrito, California); Yang Xia (Albany, California); Yuan Wang (El Cerrito, California); Xiang Zhang (Alamo, California)
ABSTRACT	This disclosure provides systems, methods, and apparatus related to optical modulators. In one aspect, a device includes a substrate, a first electrically insulating material disposed over the substrate, a first graphene layer and a second graphene layer disposed in the first electrically insulating material and being separated by the first electrically insulating material, and a waveguide disposed on the first electrically insulating material. At least a portion of the second graphene layer overlays at least a portion of the first graphene layer. The waveguide overlays both the first graphene layer and the second graphene layer.
FILED	Friday, August 17, 2018
APPL NO	16/104532
ART UNIT	2818 — Semiconductors/Memory
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/025 (20130101) G02F 1/035 (20130101) Original (OR) Class G02F 2001/0157 (20130101) G02F 2202/10 (20130101)
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10775748 — Alkali source and/or sink using ion-conducting solid electrolyte and intercalation-compound electrode

US 10775748	Roper et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Christopher S. Roper (Oak Park, California); Adam F. Gross (Santa Monica, California); Matthew T. Rakher (Oxnard, California); Logan D. Sorenson (Agoura Hills, California); John J. Vajo (West Hills, California); Jason A. Graetz (Calabasas, California); Russell Mott (Calabasas, California); Danny Kim (Agoura Hills, California)
ABSTRACT	Some variations provide an alkali metal or alkaline earth metal vapor cell with a solid ionic conductor and intercalable-compound electrodes. The intercalable-compound electrodes are used as efficient sources and/or as sinks for alkali metal or alkaline earth metal atoms, thus enabling electrical control over metal atom content in the vapor cell. Some variations provide a vapor-cell system comprising: a vapor-cell region configured to allow a vapor-cell optical path into a vapor-cell vapor phase; a first electrode; a second electrode electrically isolated from the first electrode, wherein the second electrode contains an intercalable compound intercalated by an element selected from Rb, Cs, Na, K, or Sr; and an ion-conducting layer between the first electrode and the second electrode. The ion-conducting layer is ionically conductive for at least one ionic species selected from Rb⁺, Cs⁺, Na⁺, K⁺, or Sr²⁺. The intercalable compound is preferably a carbonaceous material, such as graphite.
FILED	Thursday, December 19, 2019
APPL NO	16/720139
ART UNIT	2849 — Optics
CURRENT CPC	Production and Refining of Metals; Pretreatment of Raw Materials C22B 26/10 (20130101) Time-interval Measuring G04F 5/145 (20130101) Original (OR) Class Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/06 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101)
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10776406 — System for multi-criteria decision analysis

US 10776406	Hamilton et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	United States of America U.S. Army (Alexandria, Virginia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Alexandria, Virginia)
INVENTOR(S)	Michelle Hamilton (Alexandria, Virginia); John A Nedza (Alexandria, Virginia); Demetra E Voyadgis (Alexandria, Virginia)
ABSTRACT	This invention is a system creating risk indices, where the risk index is based on a combination of indicators. The indicators for measuring risk are adaptive and dynamic to the changing availability of disaster information and state of the system. Importantly, this research addresses two needs of emergency responders. It provides a risk-based prioritization of key geo-locations to allocate support and mitigation efforts. It provides a mechanism for prioritizing data collection and analysis efforts.
FILED	Friday, September 29, 2017
APPL NO	15/721491
ART UNIT	2161 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/24 (20190101) G06F 16/29 (20190101) Original (OR) Class G06F 17/18 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/00 (20130101) G06Q 10/10 (20130101) G06Q 10/063 (20130101) G06Q 10/0635 (20130101) G06Q 10/0637 (20130101) G06Q 50/26 (20130101) Wireless Communication Networks H04W 4/90 (20180201)
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10776450 — Closed form estimator for ballistic missile flight

US 10776450	Hansen
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Jeremiah J. Hansen (Spotsylvania, Virginia)
ASSIGNEE(S)	United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Jeremiah J. Hansen (Spotsylvania, Virginia)
ABSTRACT	A computer-implemented analysis method is provided for determining range of a ballistic missile for inclusion into a retaliatory targeting system. The method includes receiving and initializing input variables of the missile; calculating constants from the missile; determining completion of boost interval calculations; determining burnout parameters: velocity, flight path angle, and ground range at completion of boost interval for multiple stages; calculating orbital range from the burnout constraints; determining reentry intervals from which to calculate velocity and reentry range; summing boost, orbital, and reentry range values upon interval completion; and summing boost, orbital, and reentry times upon interval completion.
FILED	Monday, August 07, 2017
APPL NO	15/670150
ART UNIT	2127 — AI & Simulation/Modeling
CURRENT CPC	Weapon Sights; Aiming F41G 7/006 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 11/02 (20130101) Electric Digital Data Processing G06F 17/13 (20130101) Original (OR) Class
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10776463 — Active authentication of users

US 10776463	Stavrou et al.
FUNDED BY	Department of Homeland Security (DHS) Science and Technology Directorate (DHS-ST) Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	KRYPTOWIRE LLC (McLean, Virginia)
ASSIGNEE(S)	KRYPTOWIRE LLC (McLean, Virginia)
INVENTOR(S)	Angelos Stavrou (Fairfax, Virginia); Rahul Murmuria (Burke, Virginia); Ryan Johnson (Warrenton, Virginia); Daniel Barbara (Reston, Virginia)
ABSTRACT	Embodiments herein disclose a method and system for authenticating users of an electronic device. In an example, data pertaining to a user of the electronic device is collected for authentication. The data is data indicative of an interaction behavior of the user with the electronic device. A deviation of the collected data from a behavior model of the user is checked. To generate the behavior model, data from multiple users is collected to create the behavior model corresponding to each of the users, each behavior model is indicative of data uncommon between the user corresponding to the behavior model and other users in the plurality of users to separate the user corresponding to the behavior model from other users in the multiple users. Further, an access control policy is enforced on the electronic device, based on the deviation of the collected data from the behavior model of the user.
FILED	Monday, March 11, 2019
APPL NO	16/298829
ART UNIT	2434 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/32 (20130101) G06F 21/316 (20130101) Original (OR) Class
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10776607 — Predicting prostate cancer biochemical recurrence and metastasis with computer extracted features from tumor nuclei and benign regions

US 10776607	Madabhushi et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Center for Research Resources (NCRR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Anant Madabhushi (Shaker Heights, Ohio); Anna Gawlik (St. Charles, Illinois); George Lee (Parlin, New Jersey)
ABSTRACT	Embodiments predict biochemical recurrence (BCR) or metastasis by accessing a set of images of a region of tissue demonstrating cancerous pathology, including a tumor region and a tumor adjacent benign (TAB) region, the set of images including a first stain type image, and a second stain type image; segmenting cellular nuclei represented in the first and second image; generating a combined feature set by extracting at least one feature from each of a tumor region and TAB region represented in the first image, and a tumor region and TAB region represented in the second image, providing the combined feature set to a machine learning classifier; receiving, from the classifier, a probability that the region of tissue will experience BCR or metastasis; and generating a classification of the region of tissue as likely to experience BCR or metastasis, or unlikely to experience BCR or metastasis.
FILED	Friday, May 18, 2018
APPL NO	15/983397
ART UNIT	2649 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1475 (20130101) G01N 33/57434 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00134 (20130101) G06K 9/00147 (20130101) Original (OR) Class G06K 9/627 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0014 (20130101) G06T 7/60 (20130101) G06T 2207/10024 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30081 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/30 (20180101) G16H 50/50 (20180101)
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10776608 — Systems, methods, and apparatus for in vitro single-cell identification and recovery

US 10776608	Adalsteinsson et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Viktor A. Adalsteinsson (Wakefield, Massachusetts); Denis Loginov (Dorchester Center, Massachusetts); J. Christopher Love (Somerville, Massachusetts); Alan Stockdale (Providence, Rhode Island); Todd Gierahn (Brookline, Massachusetts)
ABSTRACT	Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
FILED	Monday, August 13, 2018
APPL NO	16/102118
ART UNIT	2485 — Recording and Compression
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 2300/12 (20130101) B01L 2300/0654 (20130101) B01L 2300/0829 (20130101) B01L 2300/0851 (20130101) B01L 2300/0896 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1425 (20130101) G01N 15/1463 (20130101) G01N 33/4833 (20130101) G01N 35/00029 (20130101) G01N 35/00871 (20130101) G01N 2015/0065 (20130101) G01N 2015/1006 (20130101) G01N 2035/00148 (20130101) Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/26 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/036 (20130101) G06K 9/00147 (20130101) Original (OR) Class G06K 9/4647 (20130101) G06K 9/4652 (20130101) G06K 9/4661 (20130101) Pictorial Communication, e.g Television H04N 5/2256 (20130101)
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10776709 — Generalized quantum channels

US 10776709	Shen et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	Yale University (New Haven, Connecticut)
INVENTOR(S)	Chao Shen (Harrison, New Jersey); Kyungjoo Noh (New Haven, Connecticut); Victor V. Albert (New Haven, Connecticut); Stefan Krastanov (New Haven, Connecticut); Michel Devoret (New Haven, Connecticut); Robert J. Schoelkopf, III (Madison, Connecticut); Steven M. Girvin (Hamden, Connecticut); Liang Jiang (Guilford, Connecticut)
ABSTRACT	According to some aspects, a quantum information system is provided that includes an ancilla qubit; a qudit coupled to the ancilla qubit, a detector configured to generate a detection result based on a quantum state of the ancilla qubit, and a driving source coupled to the qudit and the ancilla qubit and configured to apply at least one qudit driving signal to the qudit based on the detection result and at least one qubit driving signal to the qudit based on the detection result.
FILED	Friday, November 10, 2017
APPL NO	16/348131
ART UNIT	2896 — AI & Simulation/Modeling
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/08 (20130101) Transmission H04B 10/70 (20130101)
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10776710 — Multimodal data fusion by hierarchical multi-view dictionary learning

US 10776710	Lin et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Ching-Yung Lin (Scarsdale, New York); Zhen Wen (Summit, New Jersey); Yale Song (New York, New York)
ABSTRACT	Techniques for multimodal data fusion having a multimodal hierarchical dictionary learning framework that learns latent subspaces with hierarchical overlaps are provided. In one aspect, a method for multi-view data fusion with hierarchical multi-view dictionary learning is provided which includes the steps of: extracting multi-view features from input data; defining feature groups that group together the multi-view features that are related; defining a hierarchical structure of the feature groups; and learning a dictionary using the feature groups and the hierarchy of the feature groups. A system for multi-view data fusion with hierarchical multi-view dictionary learning is also provided.
FILED	Tuesday, March 24, 2015
APPL NO	14/667415
ART UNIT	2198 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 16/374 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/46 (20130101) G06K 9/00315 (20130101) G06K 9/00375 (20130101) G06K 9/629 (20130101) G06K 9/6289 (20130101) Computer Systems Based on Specific Computational Models G06N 5/003 (20130101) G06N 20/00 (20190101) Original (OR) Class
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10777093 — Automated execution and evaluation of network-based training exercises

US 10777093	Brueckner et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Architecture Technology Corporation (Minneapolis, Minnesota)
ASSIGNEE(S)	ARCHITECTURE TECHNOLOGY CORPORATION (Minneapolis, Minnesota)
INVENTOR(S)	Stephen K. Brueckner (Ithaca, New York); Frank N. Adelstein (Ithaca, New York); Haim Yehuda Bar (Ithaca, New York); Matthew P. Donovan (Trumansburg, New York)
ABSTRACT	This disclosure generally relates to automated execution and evaluation of computer network training exercises, such as in a virtual machine environment. An example environment includes a control and monitoring system, an attack system, and a target system. The control and monitoring system initiates a training scenario to cause the attack system to engage in an attack against the target system. The target system then performs an action in response to the attack. Monitor information associated with the attack against the target system is collected by continuously monitoring the training scenario. The attack system is then capable of sending dynamic response data to the target system, wherein the dynamic response data is generated according to the collected monitor information to adapt the training scenario to the action performed by the target system. The control and monitoring system then generates an automated evaluation based upon the collected monitor information.
FILED	Thursday, August 09, 2018
APPL NO	16/059716
ART UNIT	3715 — Amusement and Education Devices
CURRENT CPC	Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/00 (20130101) G09B 7/00 (20130101) G09B 9/00 (20130101) G09B 19/003 (20130101) G09B 19/0053 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 63/029 (20130101) H04L 63/145 (20130101) H04L 63/1441 (20130101) H04L 63/1458 (20130101) H04L 63/1475 (20130101)
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10777188 — Time-frequency convolutional neural network with bottleneck architecture for query-by-example processing

US 10777188	van Hout et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS) Directorate for Social, Behavioral and Economic Sciences (SBE) Division of Behavioral and Cognitive Sciences (BCS)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)	SRI International (Menlo Park, California)
INVENTOR(S)	Julien van Hout (San Francisco, California); Vikramjit Mitra (Fremont, California); Horacio Franco (Menlo Park, California); Emre Yilmaz (Clementi, Singapore)
ABSTRACT	A computing system determines whether a reference audio signal contains a query. A time-frequency convolutional neural network (TFCNN) comprises a time and frequency convolutional layers and a series of additional layers, which include a bottleneck layer. The computation engine applies the TFCNN to samples of a query utterance at least through the bottleneck layer. A query feature vector comprises output values of the bottleneck layer generated when the computation engine applies the TFCNN to the samples of the query utterance. The computation engine also applies the TFCNN to samples of the reference audio signal at least through the bottleneck layer. A reference feature vector comprises output values of the bottleneck layer generated when the computation engine applies the TFCNN to the samples of the reference audio signal. The computation engine determines at least one detection score based on the query feature vector and the reference feature vector.
FILED	Wednesday, November 14, 2018
APPL NO	16/191296
ART UNIT	2657 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 40/242 (20200101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/16 (20130101) Original (OR) Class G10L 15/22 (20130101) G10L 2015/088 (20130101)
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10777644 — Heterojunction devices and methods for fabricating the same

US 10777644	Kub et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Francis J. Kub (Arnold, Maryland); Travis J. Anderson (Alexandria, Virginia); Marko J. Tadjer (Springfield, Virginia); Andrew D. Koehler (Alexandria, Virginia); Karl D. Hobart (Alexandria, Virginia)
ABSTRACT	Current conducting devices and methods for their formation are disclosed. Described are vertical current devices that include a substrate, an n-type material layer, a plurality of p-type gates, and a source. The n-type material layer disposed on the substrate and includes a current channel. A plurality of p-type gates are disposed on opposite sides of the current channel. A source is disposed on a distal side of the current channel with respect to the substrate. The n-type material layer comprises beta-gallium oxide.
FILED	Friday, April 27, 2018
APPL NO	15/965478
ART UNIT	2891 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 29/242 (20130101) H01L 29/267 (20130101) Original (OR) Class H01L 29/0619 (20130101) H01L 29/0657 (20130101) H01L 29/802 (20130101) H01L 29/861 (20130101) H01L 29/1066 (20130101) H01L 29/1602 (20130101) H01L 29/2003 (20130101) H01L 29/7827 (20130101) H01L 29/7828 (20130101) H01L 29/8611 (20130101) H01L 29/66666 (20130101) H01L 29/66916 (20130101) H01L 29/66924 (20130101) H01L 29/66969 (20130101)
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10777696 — High absorption infrared superlattices

US 10777696	Ariyawansa et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Air Force (Wright-Paterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Gamini Ariyawansa (Dayton, Ohio); Charles J. Reyner (Mason, Ohio); John E. Scheihing (Yellow Springs, Ohio); Joshua M. Duran (Dayton, Ohio)
ABSTRACT	A ternary superlattice structure includes a substrate and periodic layer structure on the substrate and having alternating infrared absorbing semiconductor materials having a first layer of InAs_[1-x]Sb_[x]ternary alloy material, and a second layer of In_[1-y]Z_[y]As ternary alloy material, wherein Z is Ga or Al, wherein x is in a range of greater than zero and less than one, wherein y is in a range of greater than zero and less than one, and wherein a thickness of each of the first and second layers are substantially similar and configured to absorb light in a predetermined spectral band and prevent trapping of carriers in any particular layer. In examples, y is in a range from about 0.05 to about 0.35, and x is in a range of about 0.2 to about 0.8.
FILED	Tuesday, July 23, 2019
APPL NO	16/519083
ART UNIT	2898 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/109 (20130101) H01L 31/1844 (20130101) H01L 31/03046 (20130101) H01L 31/035236 (20130101) Original (OR) Class
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10777700 — Optoelectronic devices based on thin single-crystalline semiconductor films and non-epitaxial optical cavities

US 10777700	Ma et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Energy (DOE) National Nuclear Security Administration (NNSA)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin); The Research Foundation for the State University of New York (Amherst, New York)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin); The Research Foundation for the State University of New York (Amherst, New York)
INVENTOR(S)	Zhenqiang Ma (Middleton, Wisconsin); Zhenyang Xia (Madison, Wisconsin); Qiaoqiang Gan (Buffalo, New York); Haomin Song (Buffalo, New York); Zongfu Yu (Madison, Wisconsin); Ming Zhou (Middleton, Wisconsin)
ABSTRACT	Optoelectronic devices that use very thin single-crystalline inorganic semiconductor films as phonon-absorbing layers in combination with non-lattice optical cavities are provided.
FILED	Friday, June 02, 2017
APPL NO	15/612187
ART UNIT	2878 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) G01J 1/0209 (20130101) G01J 1/0488 (20130101) G01J 3/42 (20130101) G01J 3/0259 (20130101) G01J 3/2803 (20130101) G01J 5/0862 (20130101) G01J 2001/0481 (20130101) G01J 2003/1213 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1443 (20130101) H01L 31/028 (20130101) H01L 31/032 (20130101) H01L 31/0296 (20130101) H01L 31/0304 (20130101) H01L 31/1136 (20130101) Original (OR) Class H01L 31/1808 (20130101) H01L 31/02327 (20130101)
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10777879 — Optimal permeable antenna flux channels for conformal applications

US 10777879	Diaz et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Rodolfo E. Diaz (Phoenix, Arizona); Tara Yousefi (Tempe, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S)	Rodolfo E. Diaz (Phoenix, Arizona); Tara Yousefi (Tempe, Arizona)
ABSTRACT	Permeable antennas are presented. In embodiments, a permeable antenna may include a flux channel comprising a permeable material inside a trough in a conducting ground plane, the trough having a depth d and a width b; and a capacitive shunt admittance provided at the mouth of the trough. In embodiments, the capacitive shunt admittance may be one of: a slitted conducting plane or a single feed parallel solenoid, fed by a transmission line at a center loop. In embodiments, the conducting material may be anisotropic, and may include a ferromagnetic laminate comprising alternating thin metal films with thin insulating dielectrics. Related methods of providing permeable antennas are also presented.
FILED	Tuesday, July 24, 2018
APPL NO	16/044324
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/36 (20130101) H01Q 1/48 (20130101) H01Q 1/362 (20130101) Original (OR) Class
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10777883 — Phase-conjugate antenna system

US 10777883	Coleman et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Research Laboratory (NRL)
APPLICANT(S)	Envisioneering, Inc. (Alexandria, Virginia)
ASSIGNEE(S)	Envisioneering, Inc. (Alexandria, Virginia)
INVENTOR(S)	Jeffrey Owen Coleman (Kensington, Maryland); Mark Dorsey (Elkridge, Maryland); Mark Parent (Port Tobacco, Maryland); Gary Hoover (Chantilly, Virginia); Phil Girardi (Reston, Virginia)
ABSTRACT	Various embodiments of the present disclosure provide an antenna system including a first set of receive antenna elements and a second set of transmit antenna elements. Each receive antenna element is paired with one of the transmit elements. Paired receive and transmit antenna elements point in the same azimuthal direction, and the receive antenna element feeds its paired transmit antenna element. Each receive antenna element and each transmit antenna element has a phase center, and the phase centers of the receive and transmit antenna elements are all positioned substantially along the same axis. The receive and transmit elements are arranged in a phase-conjugate configuration such that, for each pair of receive and transmit antenna elements, those receive and transmit antenna elements are altitudinally spaced substantially the same distance from a plane through the antenna system.
FILED	Tuesday, October 24, 2017
APPL NO	15/791820
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/021 (20130101) G01S 7/38 (20130101) Antennas, i.e Radio Aerials H01Q 1/525 (20130101) Original (OR) Class H01Q 13/02 (20130101) H01Q 21/22 (20130101) H01Q 21/064 (20130101) H01Q 21/205 (20130101) Secret Communication; Jamming of Communication H04K 3/43 (20130101)
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10777894 — Mechanically reconfigurable patch antenna

US 10777894	McMichael
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S)	The MITRE Corporation (McLean, Virginia)
INVENTOR(S)	Ian T. McMichael (Stow, Massachusetts)
ABSTRACT	A polarization configurable patch antenna including a radiating layer, wherein the radiating layer has a corner truncated rectangular patch shape; and a feed capacitively coupled to the radiating layer for exciting the radiating layer, wherein the radiating layer is rotatable with respect to the feed, and the antenna is configured to generate a right-hand circularly polarized radiation field when the radiating layer is in a first rotational position and a left-hand circularly polarized radiation field when the radiating layer is in a second rotational position.
FILED	Thursday, February 15, 2018
APPL NO	15/897624
ART UNIT	2845 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/521 (20130101) H01Q 9/045 (20130101) H01Q 9/0428 (20130101) Original (OR) Class
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10778194 — Automatic composition of universal filters

US 10778194	Li et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
INVENTOR(S)	Kan Li (Gainesville, Florida); Jose C. Principe (Gainesville, Florida)
ABSTRACT	Various examples related to automatically composing universal filters are presented. In one example, among others, a system includes processing circuitry that can organize data received by the system into clusters or quasi-orthogonal regions, which are organized based upon a centroid threshold distance. The data can be organized by applying a cluster and retain operation, a cluster and merge operation or a split and retain operation. The system can then determine filter weights based at least in part upon centers of the clusters; update a content addressable filter bank (CAFB) based upon the filter weights; and filter subsequently received data based upon the CAFB. In another example, a method includes receiving and organizing initial data into clusters or quasi-orthogonal regions; determining filter weights based at least in part upon centers of the clusters; updating a CAFB based upon the filter weights; and receiving and filtering subsequent data based upon the CAFB.
FILED	Tuesday, August 28, 2018
APPL NO	16/114475
ART UNIT	2182 — Computer Architecture and I/O
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 21/0043 (20130101) Original (OR) Class H03H 2021/007 (20130101) H03H 2021/0061 (20130101)
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10778218 — Transformer based gate drive circuit

US 10778218	Chandrasekaran et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Sriram Chandrasekaran (Lucas, Texas); Michael S. Hockema (Plano, Texas)
ABSTRACT	A gate drive circuit for generating asymmetric drive voltages comprises a gate drive transformer comprising: a primary winding responsive to a pulse width module (PWM) input signal to generate a bipolar signal having a positive bias voltage and a negative bias voltage; and a secondary winding responsive to the bipolar signal to generate a PWM output signal. A first charge pump is connected to the secondary winding responsive to the PWM output signal to generate a level shifted PWM output signal. A second charge pump is connected to the secondary winding to generate a readjusted PWM output signal by decreasing at least a portion of the level shifted PWM output signal. A gate switching device is connected to the first charge pump and second charge pump. A level shifted PWM output signal establishes an ON condition and the readjusted PWM output signal establishes an OFF condition of the gate MOSFET.
FILED	Tuesday, July 23, 2019
APPL NO	16/520241
ART UNIT	2842 — Electrical Circuits and Systems
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/1608 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/07 (20130101) Amplifiers H03F 3/2171 (20130101) Pulse Technique H03K 17/06 (20130101) H03K 17/063 (20130101) H03K 17/567 (20130101) H03K 17/691 (20130101) H03K 17/6871 (20130101) Original (OR) Class H03K 2217/0081 (20130101)
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10778263 — Poly phased, time-interleaved RF-DAC for multi-function frequency-agile, tunable transmitter

US 10778263	Patel et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (WPAFB, Ohio)
INVENTOR(S)	Vipul J. Patel (Dayton, Ohio); John M Emmert (Dayton, Ohio); Waleed Khalil (Dublin, Ohio)
ABSTRACT	In accordance with various embodiments of the disclosed subject matter, a system, apparatus and method is configured to provide a poly-phased, time-interleaved radio frequency (RF) digital-to-analog converter (DAC) suitable for use in radar, radio, mobile and other RF systems.
FILED	Tuesday, February 18, 2020
APPL NO	16/792934
ART UNIT	2632 — Digital Communications
CURRENT CPC	Transmission H04B 1/04 (20130101) Original (OR) Class H04B 1/0028 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/36 (20130101)
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10778270 — High dynamic range receiver integrated into a chip package

US 10778270	Jansen
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Douglas S. Jansen (Durango, Colorado)
ABSTRACT	A communications receiver. One example embodiment is a system-in-package (SIP) device, which includes a three-dimensional interposer, a first bandpass filter integrated into the three-dimensional interposer, a first integrated circuit chip on the three-dimensional interposer, a second integrated circuit chip on the three-dimensional interposer, a second bandpass filter integrated into the three-dimensional interposer, and a third bandpass filter integrated into the three-dimensional interposer. The first integrated circuit chip includes a balanced amplifier that receives a first filtered signal and suppress distortion products. The second integrated circuit chip includes a first mixer and a second mixer. The first mixer receives an output of the balanced amplifier and mixes the output with a first oscillator signal. The second bandpass filter receives an output from the first mixer and generates a second filtered signal. The second mixer receives the second filtered signal and mixes the second filtered signal with a second oscillator signal.
FILED	Wednesday, November 06, 2019
APPL NO	16/675624
ART UNIT	2645 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/66 (20130101) H01L 23/5383 (20130101) H01L 25/0655 (20130101) H01L 2223/6688 (20130101) Antennas, i.e Radio Aerials H01Q 5/314 (20150115) H01Q 21/00 (20130101) Transmission H04B 1/0007 (20130101) H04B 1/16 (20130101) Original (OR) Class
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10778291 — MIMO bolt-on device, MIMO channel emulator, and MIMO channel emulation method

US 10778291	Wang et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Contracting Command (ACC)
APPLICANT(S)	Intelligent Fusion Technology, Inc (Germantown, Maryland)
ASSIGNEE(S)	INTELLIGENT FUSION TECHNOLOGY, INC. (Germantown, Maryland)
INVENTOR(S)	Zhonghai Wang (Germantown, Maryland); Lun Li (Germantown, Maryland); Jingyang Lu (Germantown, Maryland); Genshe Chen (Germantown, Maryland); Weifeng Su (East Amherst, New York); Xingping Lin (Germantown, Maryland); Xingyu Xiang (Germantown, Maryland); Wenhao Xiong (Germantown, Maryland)
ABSTRACT	A multiple-input and multiple-output (MIMO) bolt-on device for a single-input and single-output (SISO) radio, a MIMO channel emulator for testing the MIMO bolt-on device, and a MIMO channel emulation method are provided. The MIMO bolt-on device includes: a plurality of antennas, a multi-channel receiver, a plurality of couplers, a micro-controller, and a switch device. The multi-channel receiver includes a plurality of channels for signal transmission. Each coupler is configured to couple the multi-channel receiver with one of the plurality of antennas. The micro-controller is coupled to the multi-channel receiver to compare signals from the plurality of channels, thereby identifying a channel with a highest signal-to-noise (SNR) among the plurality of channels. The switch device is coupled to the micro-controller and configured to select an antenna corresponding to the channel with the highest SNR among the plurality of antennas for a connection between a selected antenna and the SISO radio.
FILED	Tuesday, March 19, 2019
APPL NO	16/358114
ART UNIT	2633 — Digital Communications
CURRENT CPC	Transmission H04B 7/0413 (20130101) Original (OR) Class H04B 17/336 (20150115) H04B 17/3912 (20150115)
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10778451 — Device and method for hardware timestamping with inherent security

US 10778451	Ramlall
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Rohan Y. Ramlall (Brentwood, California)
ABSTRACT	Disclosed are physical unclonable functions (“PUFs”) that provide both a hardware timestamp and an encryption key. The timestamp is more accurate than traditional timestamps generated by software calls to the computing device's operating system, while the encryption key can be used for, among other things, securing time-synchronization packets sent across a network. By combining timestamp generation with encryption key generation, the PUFs provide enhanced security while being cheaper to build and to operate than the specialized cryptographic hardware that they replace.
FILED	Monday, July 30, 2018
APPL NO	16/048841
ART UNIT	2498 — Cryptography and Security
CURRENT CPC	Pulse Technique H03K 3/037 (20130101) H03K 3/0315 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0861 (20130101) H04L 9/0894 (20130101) H04L 9/3278 (20130101) Original (OR) Class H04L 9/3297 (20130101)
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10778722 — Dynamic flow system

US 10778722	Hobson et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Thomas R. Hobson (Belmont, Massachusetts); William W. Streilein (Sudbury, Massachusetts); Hamed Okhravi (Billerica, Massachusetts); Richard W. Skowyra (Somerville, Massachusetts); Kevin S. Bauer (Westford, Massachusetts); Veer S. Dedhia (Somerville, Massachusetts); David O. Bigelow (Maynard, Massachusetts)
ABSTRACT	System and methods for communicating across a network comprise: a database containing high level security rules for the network; computing devices communicating on the network; a security rule translation module; event sensors configured to monitor and detect one or more events occurring on or relating to the network, and in response thereto, provide to the security rule translation module an indication of occurrence for each of the one or more security events. The security rule translation module may associate the security rules with the security events corresponding to the received indication, and produce a low-level security rule based on data from the high-level security rule and the received indication of occurrence of the security events. The system may also include switches coupled to receive the low-level security rules from the security rule translation module and enforce the low-level security rules on the network.
FILED	Tuesday, November 08, 2016
APPL NO	15/346072
ART UNIT	2497 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 63/20 (20130101) Original (OR) Class H04L 63/0263 (20130101) H04L 63/1416 (20130101)
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10779089 — Thermoacoustic device with acoustically transparent housing

US 10779089	Schumacher et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Newport, Rhode Island)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (, None)
INVENTOR(S)	Christian R Schumacher (Newport, Rhode Island); Thomas R Howarth (Portsmouth, Rhode Island)
ABSTRACT	A thermoacoustic device includes an outer shell having two half shells, each half shell having an outer flange and an inner region. The half shells are joined at the outer flanges such that the combined half shell inner regions define an inner cavity. A gas is provided within the outer shell inner cavity, and a substrate having electrodes is supported within the outer shell. A thermoacoustic element is mounted on the substrate in contact with the electrodes. Leads extend into the shell where they are joined to the electrodes. In further embodiments, the device is provided with a gas source and a regulator for controlling gas pressure in the inner cavity.
FILED	Thursday, June 13, 2019
APPL NO	16/439745
ART UNIT	2651 — Videophones and Telephonic Communications
CURRENT CPC	Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 15/04 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/02 (20130101) H04R 23/002 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Department of Energy (DOE)

10772272 — Algae cultivation systems and methods with reduced energy loss

US 10772272	Hazlebeck
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Global Algae Innovations, Inc. (San Diego, California)
ASSIGNEE(S)	Global Algae Technologies, LLC (Santee, California)
INVENTOR(S)	David A. Hazlebeck (El Cajon, California)
ABSTRACT	An open raceway algae cultivation system includes a channel configured to contain an algae cultivation fluid. The channel includes a contraction zone having a width and a depth. A pump is configured to circulate the algae cultivation fluid in the channel. A width of the contraction zone decreases leading into the entrance of the pump and a depth of the contraction zone is greater than a depth of at least a portion of the channel located outside of the contraction zone.
FILED	Tuesday, May 09, 2017
APPL NO	15/590441
ART UNIT	3643 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 33/00 (20130101) Original (OR) Class New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 4/00 (20130101) A01H 13/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/02 (20130101) C12M 23/18 (20130101) C12M 23/38 (20130101) C12M 31/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Technologies for Adaptation to Climate Change Y02A 40/88 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

10772952 — Antiviral vaccines with improved cellular immunogenicity

US 10772952	Barouch et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Dan H. Barouch (Boston, Massachusetts); Bette T. Korber (Los Alamos, New Mexico); William M. Fischer (Los Alamos, New Mexico)
ABSTRACT	The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
FILED	Friday, June 14, 2019
APPL NO	16/441703
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 39/235 (20130101) A61K 39/275 (20130101) A61K 2039/53 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10043 (20130101) C12N 2710/10343 (20130101) C12N 2710/24043 (20130101) C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) C12N 2740/16171 (20130101) C12N 2740/16222 (20130101) C12N 2740/16234 (20130101) C12N 2740/16271 (20130101) C12N 2740/16322 (20130101) C12N 2740/16334 (20130101) Technologies for Adaptation to Climate Change Y02A 50/467 (20180101)
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10773203 — Transition group metals for the capture of radioactive xenon

US 10773203	Riddle et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE) Idaho National Laboratory (INL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S)	Energy, United States Department of (Washington, District of Columbia)
ASSIGNEE(S)	U.S. Department of Energy (Washington, District of Columbia)
INVENTOR(S)	Catherine Riddle (Idaho Falls, Idaho); Dawn M. Scates (Idaho Falls, Idaho); Troy G. Garn (Idaho Falls, Idaho); Matthew G. Watrous (Idaho Falls, Idaho)
ABSTRACT	A xenon capture system that reduces the concentration of xenon in a carrier gas is disclosed. An example xenon capture system includes a carrier gas with a first concentration of xenon that flows through an intake into a chamber. Within the chamber is a reaction area that has at least one peripheral sidewall. The reaction area operates at a predetermined temperature, flow rate, and low pressure. Within the reaction area is at least one xenon capture mechanism that is at least partially formed of a transition metal. When the carrier gas is exposed to the xenon capture mechanism, the xenon capture mechanism adsorbs xenon from the carrier gas. The carrier gas, with a second concentration of xenon, exits the chamber through the exhaust outlet.
FILED	Wednesday, September 27, 2017
APPL NO	15/716955
ART UNIT	1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 53/02 (20130101) B01D 53/047 (20130101) B01D 53/0407 (20130101) Original (OR) Class B01D 53/0454 (20130101) B01D 53/0462 (20130101) B01D 2253/1122 (20130101) B01D 2256/18 (20130101) B01D 2257/11 (20130101) B01D 2259/40007 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/04 (20130101) B01J 20/0225 (20130101) B01J 20/0237 (20130101) B01J 20/0244 (20130101) B01J 20/0248 (20130101)
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10773205 — Capture and release of acid gasses using tunable organic solvents with aminopyridine

US 10773205	Koech et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S)	BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
INVENTOR(S)	Phillip K. Koech (Richland, Washington); Deepika Malhotra (Richland, Washington); David J. Heldebrant (Richland, Washington); Vassiliki-Alexandra Glezakou (Richland, Washington); Roger J. Rousseau (Richland, Washington); David C. Cantu (Reno, Nevada)
ABSTRACT	A class of water lean, organic solvents that can bind with various acid gasses to form acid gas bound molecules having a high degree of intramolecular hydrogen bonding which enables their use as regenerable solvents for acid gas capture. Unlike the other devices described in the prior art, the present invention takes advantage of shortened distances between the portions of the molecule that form hydrogen bonds within the structures when loaded with an acid gas so as to create a molecule with a higher internal bonding affinity and a reduced proclivity for agglomeration with other molecules.
FILED	Thursday, August 15, 2019
APPL NO	16/541723
ART UNIT	1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Separation B01D 53/1425 (20130101) Original (OR) Class B01D 53/1456 (20130101) B01D 53/1493 (20130101) B01D 2252/2041 (20130101) B01D 2252/20426 (20130101) B01D 2252/20431 (20130101) B01D 2252/20457 (20130101) B01D 2257/302 (20130101) B01D 2257/308 (20130101) B01D 2257/504 (20130101)
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10773228 — Self-sealing container for protecting air sensitive samples

US 10773228	Simon et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Kevin Patrick Simon (Somerville, Massachusetts); Lukas W. Porz (Boppard, Germany)
ABSTRACT	A self-sealing container, used for transferring one or more air sensitive samples between vacuum systems, includes a housing with a cavity that holds the sample(s), and a lid disposed on top of the housing. The lid is configured to interface with the housing to form a seal over the cavity when the lid is closed. At least two flexure systems, each coupled to the housing and the lid, are disposed on opposing sides of the housing. The flexure systems apply forces to the lid that move the lid horizontally and vertically above the housing, into an open position. A pneumatic actuator, movably coupled to the housing and the lid, that is actuated by a change in ambient pressure. When actuated, it applies forces that move the lid horizontally and vertically to the closed position, in opposition to and in excess of the forces applied by the flexure systems.
FILED	Tuesday, July 18, 2017
APPL NO	16/318522
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 3/03 (20130101) Original (OR) Class Machines, Apparatus or Devices For, or Methods Of, Packaging Articles or Materials; Unpacking B65B 31/046 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 51/1672 (20130101) B65D 51/1683 (20130101) B65D 81/2007 (20130101) B65D 81/2015 (20130101) B65D 81/2069 (20130101)
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10774044 — Conducting reactions in Leidenfrost-levitated droplets

US 10774044	Cooks et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Robert Graham Cooks (West Lafayette, Indiana); Christopher Pulliam (West Lafayette, Indiana); Ryan M. Bain (West Lafayette, Indiana)
ABSTRACT	The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.
FILED	Monday, June 05, 2017
APPL NO	15/613520
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 45/72 (20130101) C07C 45/72 (20130101) C07C 49/747 (20130101) Heterocyclic Compounds C07D 209/40 (20130101) C07D 213/04 (20130101) Original (OR) Class Steroids C07J 41/0005 (20130101)
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10774118 — Peptides having reduced toxicity that stimulate cholesterol efflux

US 10774118	Bielicki et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	John K. Bielicki (San Ramon, California); Jan Johansson (San Ramon, California); Waleed Danho (Del Mar, California)
ABSTRACT	The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer's Disease or frontotemporal dementia.
FILED	Wednesday, June 27, 2018
APPL NO	16/020395
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/17 (20130101) A61K 45/06 (20130101) A61K 47/64 (20170801) A61K 47/544 (20170801) Peptides C07K 14/435 (20130101) Original (OR) Class C07K 14/775 (20130101)
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10774338 — Generation of heritable chimeric plant traits

US 10774338	Loque et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Dominique Loque (Albany, California); Yan Liang (Emeryville, California)
ABSTRACT	The present invention provides methods and compositions for targeting enzymes involved in lignin or xylan biosynthesis using genome editing nucleases to specifically reduce content in a desired plant cell type(s).
FILED	Friday, January 16, 2015
APPL NO	14/598599
ART UNIT	1663 — Plants
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8216 (20130101) C12N 15/8246 (20130101) C12N 15/8255 (20130101) Original (OR) Class
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10774408 — High strength aluminum stamping

US 10774408	Steinebach et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	MAGNA INTERNATIONAL INC. (Aurora, Ontario, Canada)
ASSIGNEE(S)	MAGNA INTERNATIONAL INC. (Aurora, Canada)
INVENTOR(S)	Edward K. Steinebach (Oak Ridge, Tennessee); Mark Justin Jones (Knoxville, Tennessee); Jeremiah John Brady (Knoxville, Tennessee); Kenneth Ray Adams (Troy, Michigan); Gerard M. Ludtka (Oak Ridge, Tennessee)
ABSTRACT	The invention provides a method of manufacturing a component formed of an aluminum alloy for use in an automotive vehicle application, for example those requiring high strength, light-weight, and a complex three-dimensional shape. The method begins by providing a blank formed of an aluminum alloy which is already solution heat treated and tempered, and thus has a temper designation of about T4. The method further includes heating the blank to a temperature of 150° C. to 350° C., preferably 190° C. to 225° C. The method next includes quickly transferring the blank to a hot or warm forming apparatus, and stamping the blank to form the complex three-dimensional shape. Immediately after the forming step, the component has a temper designation of about T6, but preferably not greater than T6, and thus is ready for use in the automotive vehicle application without any post heat treatment or machining.
FILED	Friday, January 23, 2015
APPL NO	15/113821
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 22/022 (20130101) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 1/673 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/04 (20130101) Original (OR) Class C22F 1/05 (20130101)
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10774665 — Vertically oriented seal system for gas turbine vanes

US 10774665	Greene et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	John Ellington Greene (Greenville, South Carolina); Neelesh Nandkumar Sarawate (Niskayuna, New York)
ABSTRACT	A seal system for a gas turbine vane includes a first seal layer and an optional second seal layer. Each first seal layer includes multiple seal segments, each of which includes a first leg, a second leg, and an intermediate portion between the first leg and the second leg. Each adjacent pair of seal segments of the first seal is separated by a gap. The seal segments define a substantially complete perimeter of a seal slot in which the first seal is installed. The second seal, which is also segmented, may or may not define the substantially complete perimeter of the seal slot. If present, the second seal segments are circumferentially offset from the first seal segments to block the gaps between the first seal segments. A turbine vane including the present seal system is also disclosed.
FILED	Tuesday, July 31, 2018
APPL NO	16/050008
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/042 (20130101) F01D 11/005 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/12 (20130101) F05D 2240/55 (20130101) F05D 2240/80 (20130101) F05D 2300/5023 (20130101) F05D 2300/6033 (20130101)
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10774833 — Scroll-type machine

US 10774833	Bush
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	James William Bush (Skaneateles, New York)
ASSIGNEE(S)
INVENTOR(S)	James William Bush (Skaneateles, New York)
ABSTRACT	A scroll-type displacement machine, e.g. scroll compressor, has fixed and orbiting scrolls and an Oldham ring to prevent relative rotation between scrolls. A drive module positioned between the orbiting scroll and drive shaft incorporates an eccentric drive system and first and second counterweights for dynamic balancing. The motor, motor bearings, and motor shaft (i.e., drive shaft) are packaged as a separate, modular unit (e.g. “off-the-shelf” motor) that attaches to the compressor frame. The machine is configured as a high-side machine with a low-pressure port at a radial outer portion of the fixed scroll and a high-pressure port or discharge port located in the floor of the orbiting scroll at its axis, with high pressure flow passing over and around the eccentric drive bearing and drive mechanism. The Oldham ring is distributed on a lateral or radial plane of the scroll pair with a portion surrounding a portion of the fixed scroll and another portion surrounding a portion of the orbiting scroll. The ring may be formed as four arcuate members arranged on two levels, to occupy otherwise unused space in the scroll-type machine.
FILED	Friday, January 05, 2018
APPL NO	15/862786
ART UNIT	3649 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Rotary-piston or Oscillating-piston Machines or Engines F01C 1/0215 (20130101) F01C 17/066 (20130101) F01C 21/10 (20130101) Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps F04C 2/02 (20130101) F04C 15/0065 (20130101) F04C 18/0215 (20130101) Original (OR) Class F04C 18/0292 (20130101) F04C 23/008 (20130101) F04C 2240/30 (20130101) F04C 2240/50 (20130101) F04C 2240/60 (20130101) F04C 2240/807 (20130101)
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10775258 — Heuristic based analytics for gas leak source identification

US 10775258	Muralidhar et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Ramachandran Muralidhar (Mahopac, New York); Josephine B. Chang (Ellicott City, Maryland); Siyuan Lu (Yorktown Heights, New York); Theodore van Kessel (Millbrook, New York); Hendrik F. Hamann (Yorktown Heights, New York)
ABSTRACT	Heuristic-based techniques for gas leak source identification are provided. In one aspect, a method for identifying a location of a gas leak source includes: obtaining gas sensor data and wind data synchronously from a gas leak detection system having a network of interconnected motes comprising gas sensors and wind sensors, with the gas sensors arranged around possible gas leak sources in a given area of interest; identifying the location of the gas leak source using the gas sensor data and wind data; and determining a magnitude of gas leak from the gas leak source using the location of the gas leak source and a distance d between the location of the gas leak source and a select one of the gas sensors from which the gas sensor data was obtained. A gas leak detection system is also provided.
FILED	Tuesday, March 13, 2018
APPL NO	15/919405
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/04 (20130101) Original (OR) Class Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 5/00 (20130101) G01P 13/025 (20130101)
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10775290 — Highly portable radial differential mobility analyzer

US 10775290	Flagan et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	California Institute of Technology (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Richard C. Flagan (Pasadena, California); Stavros Amanatidis (Pasadena, California); Changhyuk Kim (Pasadena, California)
ABSTRACT	The present disclosure describes a compact and lightweight, radial-flow DMA designed to operate at low aerosol and sheath flowrates (on the order of 0.3 L/min aerosol flow, and 0.6-1.2 L/min sheath flow) and so as to classify aerosols including particles having sizes in the 10-500 nm range. Thus, the DMA is capable of operating at relatively low resolution (R_ND=2-4) to minimize both instrument volume and pumping/power requirements, while enabling size distribution measurement with the precision required for desired applications.
FILED	Tuesday, October 16, 2018
APPL NO	16/162047
ART UNIT	2896 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0266 (20130101) Original (OR) Class G01N 2015/0038 (20130101) G01N 2015/0046 (20130101)
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10775651 — Double-layer graphene optical modulators and methods of fabrication thereof

US 10775651	Dalir et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Multidisciplinary University Research Initiative (MURI) Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	Hamed Dalir (El Cerrito, California); Yang Xia (Albany, California); Yuan Wang (El Cerrito, California); Xiang Zhang (Alamo, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Hamed Dalir (El Cerrito, California); Yang Xia (Albany, California); Yuan Wang (El Cerrito, California); Xiang Zhang (Alamo, California)
ABSTRACT	This disclosure provides systems, methods, and apparatus related to optical modulators. In one aspect, a device includes a substrate, a first electrically insulating material disposed over the substrate, a first graphene layer and a second graphene layer disposed in the first electrically insulating material and being separated by the first electrically insulating material, and a waveguide disposed on the first electrically insulating material. At least a portion of the second graphene layer overlays at least a portion of the first graphene layer. The waveguide overlays both the first graphene layer and the second graphene layer.
FILED	Friday, August 17, 2018
APPL NO	16/104532
ART UNIT	2818 — Semiconductors/Memory
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/025 (20130101) G02F 1/035 (20130101) Original (OR) Class G02F 2001/0157 (20130101) G02F 2202/10 (20130101)
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10776087 — Sequence optimizations in a high-performance computing environment

US 10776087	Zhang
FUNDED BY	Department of Energy (DOE) National Security Agency (NSA)
APPLICANT(S)	INTEL CORPORATION (Santa Clara, California)
ASSIGNEE(S)	INTEL CORPORATION (Santa Clara, California)
INVENTOR(S)	Yongzhi Zhang (Wayland, Massachusetts)
ABSTRACT	Embodiments are directed to techniques to determine dataflow graph instructions comprising one or more pick/switch instruction pairs and generate a reverse static single assignment graph based on the dataflow graph instructions, the reverse static single assignment graph comprising strongly connected components, each of the strongly connected components associated with at least one of the one or more pick/switch instruction pairs. Embodiments also include traversing the reverse static single assignment graph depth-first, and replace pick/switch instructions associated with strongly connected components having configuration values with compound instructions.
FILED	Monday, June 25, 2018
APPL NO	16/017000
ART UNIT	2193 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 8/31 (20130101) G06F 8/44 (20130101) G06F 8/433 (20130101) Original (OR) Class G06F 8/443 (20130101) G06F 8/4432 (20130101)
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10776537 — Constructing a conforming Voronoi mesh for an arbitrarily-shaped enclosed geometric domain

US 10776537	Ebeida
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Mohamed Salah Ebeida (Albuquerque, New Mexico)
ABSTRACT	A computing system is described herein, where the computing system includes a processor and memory storing instructions that, when executed by the processor, cause the processor to perform the following acts: 1) receiving a computer-implemented definition of an enclosed geometric domain, wherein the geometric domain is two-dimensional; 2) determining locations of seeds for the enclosed geometric domain; 3) decomposing the enclosed geometric domain into a conforming Voronoi mesh based on the locations of the seeds, wherein the conforming Voronoi mesh comprises Voronoi cells, and further wherein the conforming Voronoi mesh is bounded by the enclosed domain; and 4) performing a numerical simulation to generate simulation results, wherein the numerical simulation is based on at least one Voronoi cell in the Voronoi cells of the conforming Voronoi mesh.
FILED	Tuesday, June 27, 2017
APPL NO	15/634734
ART UNIT	2128 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class Image Data Processing or Generation, in General G06T 11/206 (20130101)
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10776540 — Constructing a conforming voronoi mesh for an arbitrarily-shaped enclosed geometric domain

US 10776540	Ebeida
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Mohamed Salah Ebeida (Albuquerque, New Mexico)
ABSTRACT	A computing system is described herein, where the computing system includes a processor and memory storing instructions that, when executed by the processor, cause the processor to perform the following acts: 1) receiving a computer-implemented definition of an enclosed geometric domain, wherein the geometric domain is three-dimensional; 2) determining locations of seeds for the enclosed geometric domain; 3) decomposing the enclosed geometric domain into a conforming Voronoi mesh based on the locations of the seeds, wherein the conforming Voronoi mesh comprises Voronoi cells, and further wherein the conforming Voronoi mesh is bounded by the enclosed domain; and 4) performing a numerical simulation to generate simulation results, wherein the numerical simulation is based on at least one Voronoi cell in the Voronoi cells of the conforming Voronoi mesh.
FILED	Tuesday, June 27, 2017
APPL NO	15/634747
ART UNIT	2128 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 30/23 (20200101) Original (OR) Class G06F 2111/10 (20200101) Image Data Processing or Generation, in General G06T 15/10 (20130101) G06T 17/20 (20130101) G06T 19/20 (20130101)
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10776606 — Methods for delineating cellular regions and classifying regions of histopathology and microanatomy

US 10776606	Parvin et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Bahram Parvin (Mill Valley, California); Hang Chang (Moraga, California); Yin Zhou (Newark, Delaware)
ABSTRACT	Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.
FILED	Monday, September 22, 2014
APPL NO	14/493208
ART UNIT	2663 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00147 (20130101) Original (OR) Class G06K 9/6249 (20130101) G06K 9/6255 (20130101)
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10776678 — Tag and seal employing a micromachine artifact

US 10776678	Merkle
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Peter B. Merkle (St. Augustine, Florida)
ABSTRACT	A method and apparatus to authenticate a tamper resistant seal that includes a population of particles embedded in an adhesive, the population including at least one micromachine artifact of a predetermined physical shape.
FILED	Monday, May 15, 2017
APPL NO	15/594867
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/06009 (20130101) Original (OR) Class
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10776684 — Mixed core processor unit

US 10776684	Agarwal et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	Sandia Corporation (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Sapan Agarwal (Albuquerque, New Mexico); Alexander H. Hsia (Albuquerque, New Mexico); Matthew Marinella (Albuquerque, New Mexico)
ABSTRACT	A method and apparatus for processing data. The data is sent to a processor unit comprising a group of neural cores, a group of digital processing cores, and a routing network connecting the group of digital processing cores. The data is processed in the processor unit to generate a result.
FILED	Wednesday, November 02, 2016
APPL NO	15/341991
ART UNIT	2124 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Original (OR) Class G06N 3/08 (20130101)
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10776718 — Source identification by non-negative matrix factorization combined with semi-supervised clustering

US 10776718	Alexandrov et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Boian S. Alexandrov (Santa Fe, New Mexico); Ludmil B. Alexandrov (Santa Fe, New Mexico); Filip L. Iliev (Oakland, California); Valentin G. Stanev (Crofton, Maryland); Velimir V. Vesselinov (Santa Fe, New Mexico)
ABSTRACT	Machine-learning methods and apparatus are provided to solve blind source separation problems with an unknown number of sources and having a signal propagation model with features such as wave-like propagation, medium-dependent velocity, attenuation, diffusion, and/or advection, between sources and sensors. In exemplary embodiments, multiple trials of non-negative matrix factorization are performed for a fixed number of sources, with selection criteria applied to determine successful trials. A semi-supervised clustering procedure is applied to trial results, and the clustering results are evaluated for robustness using measures for reconstruction quality and cluster separation. The number of sources is determined by comparing these measures for different trial numbers of sources. Source locations and parameters of the signal propagation model can also be determined. Disclosed methods are applicable to a wide range of spatial problems including chemical dispersal, pressure transients, and electromagnetic signals, and also to non-spatial problems such as cancer mutation.
FILED	Tuesday, August 29, 2017
APPL NO	15/690176
ART UNIT	2182 — Computer Architecture and I/O
CURRENT CPC	Electric Digital Data Processing G06F 17/16 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6231 (20130101) G06K 9/6239 (20130101) G06K 9/6247 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) G06N 20/00 (20190101) Original (OR) Class
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10777381 — Beam controlled nano-robotic device

US 10777381	Kalinin et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Sergei V. Kalinin (Oak Ridge, Tennessee); Stephen Jesse (Oak Ridge, Tennessee); Ondrej E. Dyck (Oak Ridge, Tennessee); Bobby G. Sumpter (Oak Ridge, Tennessee)
ABSTRACT	A system and method (referred to as a method) to fabricate nanorobots. The method generates a pixel map of an atomic object and identifies portions of the atomic object that form a nanorobot. The method stores those identifications in a memory. The method adjusts an electron beam to a noninvasive operating level and images the portions of the atomic object that form the nanorobot. The method executes a plurality of scanning profiles by the electron beam to form the nanorobot and detects nanorobot characteristics and their surroundings via the electron beam in response to executing the plurality of scanning profiles.
FILED	Thursday, August 08, 2019
APPL NO	16/536037
ART UNIT	2881 — Optics
CURRENT CPC	Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 3/0076 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) B82Y 40/00 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/28 (20130101) H01J 37/265 (20130101) Original (OR) Class H01J 37/317 (20130101)
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10777396 — Differential electrochemical mass spectrometry (DEMS) cell

US 10777396	Clark et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Joint Center for Artificial Photosynthesis (JCAP) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Ezra L. Clark (Berkeley, California); Alexis T. Bell (Oakland, California)
ABSTRACT	The present invention provides for a differential electrochemical mass spectrometry (DEMS) cell comprising a working electrode chamber configured such that an electrolyte enters the working electrode chamber through a channel running through the working electrode.
FILED	Tuesday, November 17, 2015
APPL NO	14/944085
ART UNIT	1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/0009 (20130101) Original (OR) Class H01J 49/009 (20130101) H01J 49/14 (20130101) H01J 49/065 (20130101)
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10777400 — Ion focusing

US 10777400	Cooks et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Robert Graham Cooks (West Lafayette, Indiana); Zane Baird (West Lafayette, Indiana); Wen-Ping Peng (Hualien, Taiwan)
ABSTRACT	The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
FILED	Thursday, February 27, 2020
APPL NO	16/803023
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/06 (20130101) H01J 49/10 (20130101) H01J 49/26 (20130101) H01J 49/067 (20130101) Original (OR) Class H01J 49/165 (20130101)
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10777691 — Formed photovoltaic module busbars

US 10777691	Rose et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	SunPower Corporation (San Jose, California)
ASSIGNEE(S)	SunPower Corporation (San Jose, California)
INVENTOR(S)	Douglas Rose (Mountain View, California); Shan Daroczi (Santa Clara, California); Thomas Phu (Alameda, California)
ABSTRACT	A method and apparatus directed to busbar components for photovoltaic modules.
FILED	Tuesday, October 16, 2018
APPL NO	16/162053
ART UNIT	1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/05 (20130101) H01L 31/0201 (20130101) Original (OR) Class H01L 31/0465 (20141201) H01L 31/0508 (20130101) H01L 31/0516 (20130101) H01L 31/02013 (20130101) H01L 31/022441 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/34 (20141201) H02S 40/36 (20141201) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101)
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10777700 — Optoelectronic devices based on thin single-crystalline semiconductor films and non-epitaxial optical cavities

US 10777700	Ma et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Energy (DOE) National Nuclear Security Administration (NNSA)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin); The Research Foundation for the State University of New York (Amherst, New York)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin); The Research Foundation for the State University of New York (Amherst, New York)
INVENTOR(S)	Zhenqiang Ma (Middleton, Wisconsin); Zhenyang Xia (Madison, Wisconsin); Qiaoqiang Gan (Buffalo, New York); Haomin Song (Buffalo, New York); Zongfu Yu (Madison, Wisconsin); Ming Zhou (Middleton, Wisconsin)
ABSTRACT	Optoelectronic devices that use very thin single-crystalline inorganic semiconductor films as phonon-absorbing layers in combination with non-lattice optical cavities are provided.
FILED	Friday, June 02, 2017
APPL NO	15/612187
ART UNIT	2878 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) G01J 1/0209 (20130101) G01J 1/0488 (20130101) G01J 3/42 (20130101) G01J 3/0259 (20130101) G01J 3/2803 (20130101) G01J 5/0862 (20130101) G01J 2001/0481 (20130101) G01J 2003/1213 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1443 (20130101) H01L 31/028 (20130101) H01L 31/032 (20130101) H01L 31/0296 (20130101) H01L 31/0304 (20130101) H01L 31/1136 (20130101) Original (OR) Class H01L 31/1808 (20130101) H01L 31/02327 (20130101)
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10777724 — Hybrid solar system

US 10777724	Cygan et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	GAS TECHNOLOGY INSTITUTE (Des Plaines, Illinois); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ON BEHALF OF ITS MERCED CAMPUS (Merced, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ON BEHALF OF ITS BERKELEY CAMPUS (Berkeley, California)
ASSIGNEE(S)	Gas Technology Institute (Des Plaines, Illinois); The Regents of the University of California on behalf of its Merced Campus (Merced, California); The Regents of the University of California on behalf of its Berkley Campus (Berkley, California)
INVENTOR(S)	David Cygan (Villa Park, Illinois); Hamid Abbasi (Naperville, Illinois); Aleksandr Kozlov (Buffalo Grove, Illinois); Roland Winston (Merced, California); Eli Yablonovitch (Oakland, California)
ABSTRACT	A hybrid solar system including a hybrid solar collector using non-imaging optics and photovoltaic components and a heat transfer and storage system in thermal communication with the hybrid solar collector, the heat transfer and storage system using particle laden gas as thermal media to simultaneously generate and store electricity and high temperature dispatchable heat.
FILED	Monday, July 30, 2018
APPL NO	16/049205
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Solar Heat Collectors; Solar Heat Systems F24S 23/80 (20180501) F24S 2023/84 (20180501) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/046 (20141201) H01L 35/02 (20130101) Original (OR) Class Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/22 (20141201) H02S 40/44 (20141201) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/52 (20130101) Y02E 10/60 (20130101)
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10777811 — Lithium-sulfur battery with lithium polysulfide catholyte

US 10777811	Zhang et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S)	Zhengcheng Zhang (Naperville, Illinois); Zheng Xue (Burr Ridge, Illinois); Feng Zhao (Salt Lake City, Utah)
ABSTRACT	A liquid catholyte for a Li—S battery comprises a non-aqueous solution of at least one lithium polysulfide of formula Li₂S_x(wherein x is selected from 4, 6, and 8) and an anion receptor compound capable of complexing with polysulfide anion. The non-aqueous solution typically is composed of the Li₂S_xand the anion receptor compound dissolved in a non-aqueous solvent (e.g., one or more organic ether or fluorinated ether solvents). The anion receptor compound typically is present in the catholyte at a concentration of about 0.1 M to about 4 M. Li—S batteries comprise a metallic lithium anode; a porous conductive substrate; a separator membrane between the anode and the porous conductive substrate; and the liquid catholyte composition within pores of the substrate.
FILED	Friday, March 02, 2018
APPL NO	15/910802
ART UNIT	1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/1646 (20130101) H01M 2/1653 (20130101) H01M 2/1686 (20130101) H01M 4/80 (20130101) H01M 4/134 (20130101) H01M 4/368 (20130101) Original (OR) Class H01M 4/663 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2300/0028 (20130101)
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10777852 — Overcharge protection of batteries using current interrupt devices

US 10777852	Woodford et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	24M Technologies, Inc. (Cambridge, Massachusetts); Kyocera Corporation (Kyoto, Japan)
ASSIGNEE(S)	24M Technologies, Inc. (Cambridge, Massachusetts); Kyocera Corporation (Kyoto, Japan)
INVENTOR(S)	William Henry Woodford (Cambridge, Massachusetts); Naoki Ota (Lexington, Massachusetts); Takaaki Fukushima (Okayama, Japan); Jeffry Disko (North Brookfield, Massachusetts); Junzheng Chen (Concord, Massachusetts)
ABSTRACT	A battery system includes a main electrochemical cell that includes a cathode and an anode, a cathode tab electrically coupled to the cathode, and an anode tab electrically coupled to the anode. A second electrochemical cell is electrically coupled to the cathode tab and the anode tab. An interrupt device, such as a bi-stable metal disc, is operably coupled to the second electrochemical cell and at least one of the cathode tab or the anode tab. Upon overcharging of the main electrochemical cell, the voltage between the cathode tab and the anode tab causes the second electrochemical cell to generate gases that triggers the interrupt device, which in turn disconnects at least one of the cathode tab or the anode tab, thereby protecting the main electrochemical cell from further damages.
FILED	Friday, March 30, 2018
APPL NO	15/941673
ART UNIT	1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/345 (20130101) H01M 10/0431 (20130101) H01M 10/445 (20130101) Original (OR) Class H01M 10/4235 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0029 (20130101) H02J 7/00302 (20200101)
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10777855 — Embedded fiber optic cables for battery management

US 10777855	Raghavan et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
INVENTOR(S)	Ajay Raghavan (Mountian View, California); Peter Kiesel (Palo Alto, California); Lars Wilko Sommer (Bretten, Germany); Bhaskar Saha (Redwood City, California); Saroj Sahu (Fremont, California); Alexander Lochbaum (Landau, Germany); Tobias Staudt (Neurnberg, Germany); Chang-Jun Bae (Mountain View, California); Mohamed Alamgir (Rochester Hills, Michigan); Hoe Jin Hah (Daejeon, South Korea); Bokkyu Choi (Tokyo, Japan); Gyu-Ok Hwang (Daejeon, South Korea); Geun-Chang Chung (Daejeon, South Korea)
ABSTRACT	A battery includes a folded bicell battery stack with an embedded fiber optic cable and sensor. A cell casing encloses the bicell stack with at least one fiber optic cable is embedded within the battery. The fiber optic cable includes an internal portion disposed within the cell casing and having at least one optical sensor disposed thereon. An external portion of the fiber optic cable protrudes from the casing. A sealing gasket is disposed at least partially around the fiber optic cable and between the cell sealing edges at a point of entry of the fiber optic cable into the battery.
FILED	Tuesday, September 03, 2019
APPL NO	16/559029
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/32 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/242 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/06 (20130101) H01M 2/08 (20130101) H01M 2/1061 (20130101) H01M 10/052 (20130101) H01M 10/0431 (20130101) H01M 10/0459 (20130101) H01M 10/482 (20130101) Original (OR) Class H01M 10/486 (20130101) H01M 10/4257 (20130101)
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10777964 — Method and system for compact efficient laser architecture

US 10777964	Bayramian et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
INVENTOR(S)	Andrew James Bayramian (Manteca, California); Kenneth Manes (Brentwood, California); Robert J. Deri (Pleasanton, California); Al Erlandson (Livermore, California); John Caird (San Francisco, California); Mary Spaeth (Brentwood, California)
ABSTRACT	A laser amplifier module having an enclosure includes an input window, a mirror optically coupled to the input window and disposed in a first plane, and a first amplifier head disposed along an optical amplification path adjacent a first end of the enclosure. The laser amplifier module also includes a second amplifier head disposed along the optical amplification path adjacent a second end of the enclosure and a cavity mirror disposed along the optical amplification path.
FILED	Thursday, October 24, 2019
APPL NO	16/663122
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/005 (20130101) H01S 3/027 (20130101) H01S 3/0071 (20130101) H01S 3/0404 (20130101) H01S 3/0941 (20130101) H01S 3/1308 (20130101) H01S 3/2316 (20130101) H01S 3/2341 (20130101) Original (OR) Class H01S 3/08072 (20130101) H01S 3/09408 (20130101) H01S 3/09415 (20130101) H01S 3/10007 (20130101) H01S 3/10061 (20130101)
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National Science Foundation (NSF)

10772560 — Skin-mounted hydration sensor and management system

US 10772560	Ziaie et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Office of Emerging Frontiers in Research and Innovation (EFRI)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Babak Ziaie (West Lafayette, Indiana); Manuel P. Ochoa (Lafayette, Indiana); Vaibhav Jain (West Lafayette, Indiana); Rahim Rahimi (West Lafayette, Indiana)
ABSTRACT	A wearable paper-based platform with simultaneous passive and active feedback for monitoring perspiration is provided. The sensor platform comprises two modules: a disposable wicking-based sweat collection patch with discrete colorimetric feedback, and a reusable electronic detachable module for active feedback. The disposable patch comprises a hygroscopic wicking material laminated between two polymeric films. The wicking material is patterned with a radial finger design that offers discretized visual readout of the sensor. The active module attaches to the film and alerts the user when the film collects a pre-determined volume of sweat. The multi-feedback system allows high-performance athletes who value objective quantification of perspiration to better assess their sweat loss during physical activities.
FILED	Monday, October 02, 2017
APPL NO	15/723157
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0537 (20130101) A61B 5/4875 (20130101) Original (OR) Class A61B 5/6833 (20130101) A61B 5/14517 (20130101) A61B 2503/10 (20130101) A61B 2560/0412 (20130101) A61B 2562/04 (20130101) A61B 2562/12 (20130101) A61B 2562/0214 (20130101)
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10772909 — System and method for insulin-mimetic of cartilage, bone, or osteochondral repair and piezoelectric composite scaffold

US 10772909	Arinzeh et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	New Jersey Institute of Technology (Newark, New Jersey)
ASSIGNEE(S)	New Jersey Institute of Technology (Newark, New Jersey)
INVENTOR(S)	Treena Lynne Arinzeh (West Orange, New Jersey); Ateka Khader (Kearny, New Jersey)
ABSTRACT	Shown and described is an insulin-mimetic as an inductive agent for cartilage and/or bone repair is disclosed. Sodium tungstate (Na₂WO₄) was utilized as an inductive factor to enhance human mesenchymal stem cell (MSC) chondrogenesis. The chondrogenic differentiation of MSCs was enhanced in the presence of low concentrations of Na₂WO₄as compared to control, without Na₂WO₄. Also disclosed is a composite scaffold capable of supporting cell and tissue growth. The composite scaffold could include zinc oxide and polycaprolactone.
FILED	Monday, October 02, 2017
APPL NO	15/722299
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 33/24 (20130101) Original (OR) Class A61K 33/30 (20130101) A61K 35/28 (20130101) A61K 47/02 (20130101) A61K 47/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/18 (20130101) A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/446 (20130101) A61L 27/446 (20130101) A61L 27/3834 (20130101) A61L 2300/102 (20130101) A61L 2300/412 (20130101) A61L 2400/12 (20130101) Compositions of Macromolecular Compounds C08L 67/04 (20130101) C08L 67/04 (20130101)
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10773217 — Polyacid-functionalized porous membranes, related methods, and related polyacid polymers

US 10773217	Bruening et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan)
ASSIGNEE(S)	BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan)
INVENTOR(S)	Merlin L. Bruening (East Lansing, Michigan); Salinda Wijeratne (East Lansing, Michigan); Wenjing Ning (East Lansing, Michigan); Jinlan Dong (East Lansing, Michigan); Weijing Liu (East Lansing, Michigan)
ABSTRACT	The disclosure relates to processes, related polyacid polymers, and related articles for functionalizing a porous membrane by contacting the membrane with a polyacid polymer at low pH to stably adsorb a polyacid layer on the membrane pore surface, in particular polyacid polymers including repeating units with a pendent metal-binding ligand or star polyacid polymers. The resulting functionalized membrane is characterized by a high density of free acid groups, resulting in a higher specific capacity for its intended application. The process allows functionalization of porous membranes in a very simple, one-step process, for example without a need to derivatize an adsorbed polyacid layer to impart metal-binding ligand functionality thereto. Such functional membranes may find multiple uses, including rapid, selective binding of proteins for their purification or immobilization.
FILED	Wednesday, November 04, 2015
APPL NO	15/524483
ART UNIT	1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 67/0088 (20130101) B01D 67/0093 (20130101) B01D 69/02 (20130101) B01D 69/141 (20130101) B01D 69/142 (20130101) Original (OR) Class B01D 69/144 (20130101) B01D 71/38 (20130101) B01D 71/40 (20130101) B01D 71/60 (20130101) B01D 71/64 (20130101) B01D 71/82 (20130101) Compositions of Macromolecular Compounds C08L 73/02 (20130101) C08L 77/02 (20130101)
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10773330 — Measurement of three-dimensional welding torch orientation for manual arc welding process

US 10773330	Zhang et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
INVENTOR(S)	Yuming Zhang (Nicholasville, Kentucky); WeiJie Zhang (Windsor, Canada)
ABSTRACT	Methods and systems are provided herein for measuring 3D apparatus (e.g., manual tool or tool accessory) orientation. Example implementations use an auto-nulling algorithm that incorporates a quaternion-based unscented Kalman filter. Example implementations use a miniature inertial measurement unit endowed with a tri-axis gyro and a tri-axis accelerometer. The auto-nulling algorithm serves as an in-line calibration procedure to compensate for the gyro drift, which has been verified to significantly improve the estimation accuracy in three-dimensions, especially in the heading estimation.
FILED	Tuesday, May 22, 2018
APPL NO	15/986300
ART UNIT	2855 — Printing/Measuring and Testing
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 9/0953 (20130101) Original (OR) Class Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/16 (20130101) G01C 25/00 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 21/00 (20130101)
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10774044 — Conducting reactions in Leidenfrost-levitated droplets

US 10774044	Cooks et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Robert Graham Cooks (West Lafayette, Indiana); Christopher Pulliam (West Lafayette, Indiana); Ryan M. Bain (West Lafayette, Indiana)
ABSTRACT	The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.
FILED	Monday, June 05, 2017
APPL NO	15/613520
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 45/72 (20130101) C07C 45/72 (20130101) C07C 49/747 (20130101) Heterocyclic Compounds C07D 209/40 (20130101) C07D 213/04 (20130101) Original (OR) Class Steroids C07J 41/0005 (20130101)
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10774107 — DNA gridiron compositions and methods

US 10774107	Han et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S)	Dongran Han (Cambridge, Massachusetts); Hao Yan (Chandler, Arizona)
ABSTRACT	Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
FILED	Wednesday, November 28, 2018
APPL NO	16/202841
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 21/04 (20130101) Original (OR) Class
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10774349 — Alpha omega bifunctional fatty acids

US 10774349	San et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	William Marsh Rice University (Houston, Texas)
ASSIGNEE(S)	William Marsh Rice University (Houston, Texas)
INVENTOR(S)	Ka-Yiu San (Houston, Texas); Dan Wang (Houston, Texas)
ABSTRACT	The present disclosure describes an engineered microorganism for producing alpha omega bifunctional C6-16 fatty acids from renewable carbon sources.
FILED	Saturday, May 07, 2016
APPL NO	15/572099
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Producing, e.g by Pressing Raw Materials or by Extraction From Waste Materials, Refining or Preserving Fats, Fatty Substances, e.g Lanolin, Fatty Oils or Waxes; Essential Oils; Perfumes C11B 1/00 (20130101) Fatty Acids From Fats, Oils or Waxes; Candles; Fats, Oils or Fatty Acids by Chemical Modification of Fats, Oils, or Fatty Acids Obtained Therefrom C11C 1/002 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/13 (20130101) C12N 9/16 (20130101) C12N 9/88 (20130101) C12N 9/93 (20130101) C12N 9/1029 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6409 (20130101) Original (OR) Class
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10774430 — Carbon dioxide reduction and carbon compound electrochemistry in the presence of lanthanides

US 10774430	Leddy et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Johna Leddy (Iowa City, Iowa); Nadeesha P. W. Rathuwadu (Iowa City, Iowa)
ASSIGNEE(S)
INVENTOR(S)	Johna Leddy (Iowa City, Iowa); Nadeesha P. W. Rathuwadu (Iowa City, Iowa)
ABSTRACT	Electrochemically reacting C-1 compounds including carbon dioxide, formic acid, formaldehyde, methanol, carbon monoxide in the presence of at least one lanthanide and/or at least one actinide. Reducing carbon dioxide or reacting C-1 compounds such as HCOOH (formic acid), HCHO (formaldehyde), CH₃OH (methanol), or CO (carbon monoxide) with use of an electrochemical device, wherein the device comprises at least one cathode, and at least one anode, and at least one electrolyte between the cathode and the anode, wherein the electrolyte comprises at least one lanthanide and/or actinide compound. The electrode can be modified with a film such as an ionically conducting or ionically permeable film, optionally comprising a magnetic material. Polar organic solvent such as acetonitrile can be used. Electrocatalysis and/or reaction mediation is observed. Devices can be adapted to carry out the methods. The device can be part of a fuel cell, a battery, an electrolyzer, or an electrosynthetic device.
FILED	Wednesday, October 04, 2017
APPL NO	15/724481
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/00 (20130101) C25B 3/00 (20130101) C25B 3/04 (20130101) Original (OR) Class C25B 9/06 (20130101) C25B 9/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) H01M 8/1016 (20130101)
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10775322 — Inert crystal delivery medium for serial femtosecond crystallography

US 10775322	Conrad et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Biological Infrastructure (DBI)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Chelsie Conrad (Phoenix, Arizona); Petra Fromme (Mesa, Arizona); Daniel James (Mesa, Arizona); Christopher Kupitz (Scottsdale, Arizona)
ABSTRACT	A system and method for preparing a crystal delivery medium comprising agarose for serial femtosecond crystallography and uses thereof.
FILED	Wednesday, June 15, 2016
APPL NO	15/183149
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/14 (20130101) C30B 29/58 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/2005 (20130101) Original (OR) Class G01N 33/483 (20130101)
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10775354 — Autonomous ambient air sampling system for monitoring semi-volatile/non-volatile organic compounds

US 10775354	Hansen et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Geosciences (GEO) Division of Atmospheric Sciences (ATM)
APPLICANT(S)	BRIGHAM YOUNG UNIVERSITY (Provo, Utah)
ASSIGNEE(S)	Brigham Young University (Provo, Utah)
INVENTOR(S)	Jaron Hansen (Springville, Utah); Paul Cropper (Spanish Fork, Utah); Delbert J. Eatough (Provo, Utah); Robert Cary (Tigard, Oregon); Lin Lin (South Easton, Massachusetts); Lee Hansen (Saratoga Springs, Utah)
ABSTRACT	An automated ambient air sampling system and method for monitoring organic compounds that may provide continuous data, the system including a thermal desorption system, an injection port, a pre-concentration system, a gas chromatograph and an ion trap mass spectrometer, wherein an air sampling chamber may also function as a thermal desorption chamber.
FILED	Friday, October 02, 2015
APPL NO	14/874196
ART UNIT	2856 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/06 (20130101) G01N 30/16 (20130101) G01N 30/7206 (20130101) Original (OR) Class G01N 2030/025 (20130101) G01N 2030/128 (20130101) G01N 2030/884 (20130101)
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10775391 — Nervous system-specific transmembrane proteasome complex that modulates neuronal signaling through extracellular signaling via brain activity peptides

US 10775391	Margolis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH) National Science Foundation (NSF)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Seth S. Margolis (Towson, Maryland); Kapil V. Ramachandran (Baltimore, Maryland)
ABSTRACT	The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural-specific and membrane bound proteasome (neuronal membrane proteasome or NMP) that is transmembrane in nature. These secreted, activity-induced, proteasomal peptides (SNAPPs) range in size from about 500 Daltons to about 3000 Daltons. Surprisingly none of the peptides appear to be those previously known to have any neuronal function. Moreover, these SNAPPs have stimulatory activity and are heretofore a new class of signaling molecules. Moreover, the NMP appears to play a highly significant role in aspects of neuronal signaling known to be critical for neuronal function. The inventors have gone on to develop all tools to study this novel mechanisms including protocols and practice for generation and purification of SNAPPs as well as a new and specific inhibitor of the NMP allowing for selective control of this process in the nervous system. The present invention provides methods of making and using these SNAPPs for both laboratory and clinical purposes, the screening for molecules which modulate NMP function in vivo and in vitro, and methods for diagnosis of NMP related diseases.
FILED	Thursday, February 11, 2016
APPL NO	15/550632
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 31/165 (20130101) A61K 38/05 (20130101) A61K 51/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/72 (20130101) G01N 33/5023 (20130101) G01N 33/5058 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2030/8831 (20130101) G01N 2333/47 (20130101) G01N 2800/2821 (20130101)
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10776516 — Electronic medical record datasifter

US 10776516	Dinov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Nursing Research (NINR) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	The Regents of The University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Ivaylo Dinov (Ann Arbor, Michigan); John Vandervest (Ann Arbor, Michigan); Simeone Marino (Ann Arbor, Michigan)
ABSTRACT	A method is presented for generating a data set from a database. The method involves iterative data manipulation that stochastically identifies candidate entries from the cases (subjects, participants) and variables (data elements) and subsequently selects, nullifies, and imputes the information. This process heavily relies on statistical multivariate imputation to preserve the joint distributions of the complex structured data archive. At each step, the algorithm generates a complete dataset that in aggregate closely resembles the intrinsic characteristics of the original data set, however, on an individual level the rows of data are substantially altered. This procedure drastically reduces the risk for subject reidentification by stratification, as meta-data for all subjects is repeatedly and lossily encoded.
FILED	Wednesday, August 01, 2018
APPL NO	16/051881
ART UNIT	2165 — Data Bases & File Management
CURRENT CPC	Electric Digital Data Processing G06F 16/2272 (20190101) G06F 17/11 (20130101) G06F 17/18 (20130101) G06F 21/6254 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/003 (20130101) G06N 7/005 (20130101) G06N 7/08 (20130101) G06N 20/20 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/70 (20180101)
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10776709 — Generalized quantum channels

US 10776709	Shen et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE)
APPLICANT(S)	Yale University (New Haven, Connecticut)
ASSIGNEE(S)	Yale University (New Haven, Connecticut)
INVENTOR(S)	Chao Shen (Harrison, New Jersey); Kyungjoo Noh (New Haven, Connecticut); Victor V. Albert (New Haven, Connecticut); Stefan Krastanov (New Haven, Connecticut); Michel Devoret (New Haven, Connecticut); Robert J. Schoelkopf, III (Madison, Connecticut); Steven M. Girvin (Hamden, Connecticut); Liang Jiang (Guilford, Connecticut)
ABSTRACT	According to some aspects, a quantum information system is provided that includes an ancilla qubit; a qudit coupled to the ancilla qubit, a detector configured to generate a detection result based on a quantum state of the ancilla qubit, and a driving source coupled to the qudit and the ancilla qubit and configured to apply at least one qudit driving signal to the qudit based on the detection result and at least one qubit driving signal to the qudit based on the detection result.
FILED	Friday, November 10, 2017
APPL NO	16/348131
ART UNIT	2896 — AI & Simulation/Modeling
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/08 (20130101) Transmission H04B 10/70 (20130101)
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10776713 — Classification of highly-skewed data

US 10776713	Kumar et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC) National Science Foundation (NSF)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Vipin Kumar (Minneapolis, Minnesota); Varun Mithal (Minneapolis, Minnesota); Guruprasad Nayak (Minneapolis, Minnesota); Ankush Khandelwal (Minneapolis, Minnesota)
ABSTRACT	A method for identifying highly-skewed classes using an imperfect annotation of every instance together with a set of features for all instances. The imperfect annotations designate a plurality of instances as belonging to the target rare class and others to the majority class. First, a classifier is trained on the set of features using the imperfect annotation as supervision, to designate each instance to either the rare class or majority class. A combination of the predictions from the trained classifier and the imperfect annotations is then used to classify each instance to either the rare class or majority class. In particular, an instance is classified to the rare class only when both the trained classifier and the imperfect annotation classify the instance to the rare class. Finally, for each instance assigned as a rare class instance by the combination stage, all instances in its neighborhood are re-classified as either rare class or majority class.
FILED	Monday, April 25, 2016
APPL NO	15/137603
ART UNIT	2122 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class
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10777188 — Time-frequency convolutional neural network with bottleneck architecture for query-by-example processing

US 10777188	van Hout et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS) Directorate for Social, Behavioral and Economic Sciences (SBE) Division of Behavioral and Cognitive Sciences (BCS)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)	SRI International (Menlo Park, California)
INVENTOR(S)	Julien van Hout (San Francisco, California); Vikramjit Mitra (Fremont, California); Horacio Franco (Menlo Park, California); Emre Yilmaz (Clementi, Singapore)
ABSTRACT	A computing system determines whether a reference audio signal contains a query. A time-frequency convolutional neural network (TFCNN) comprises a time and frequency convolutional layers and a series of additional layers, which include a bottleneck layer. The computation engine applies the TFCNN to samples of a query utterance at least through the bottleneck layer. A query feature vector comprises output values of the bottleneck layer generated when the computation engine applies the TFCNN to the samples of the query utterance. The computation engine also applies the TFCNN to samples of the reference audio signal at least through the bottleneck layer. A reference feature vector comprises output values of the bottleneck layer generated when the computation engine applies the TFCNN to the samples of the reference audio signal. The computation engine determines at least one detection score based on the query feature vector and the reference feature vector.
FILED	Wednesday, November 14, 2018
APPL NO	16/191296
ART UNIT	2657 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC	Electric Digital Data Processing G06F 40/242 (20200101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/16 (20130101) Original (OR) Class G10L 15/22 (20130101) G10L 2015/088 (20130101)
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10777333 — Laser-based fabrication of carbon nanotube-metal composites on flexible substrates

US 10777333	Wu
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Benxin Wu (West Lafayette, Indiana)
ABSTRACT	The present disclosure relates to a novel method of laser-based fabrication of a carbon nanotube (CNT)-metal composite on a flexible substrate, and the fabricated CNT-metal composite that is bonded with the flexible substrate, and that has a high electrical conductivity, and that has a longer bending-fatigue life than the laser-sintered metal of the same type without CNTs onto the flexible substrate.
FILED	Tuesday, October 10, 2017
APPL NO	15/729078
ART UNIT	1783 — Miscellaneous Articles, Stock Material
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 1/26 (20130101) B05D 3/14 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/174 (20170801) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) H01B 1/04 (20130101) H01B 5/14 (20130101) Original (OR) Class
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10777410 — Synthesis and fabrication of transition metal dichalcogenide structures

US 10777410	Jahangir et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	University of South Carolina (Columbia, South Carolina)
ASSIGNEE(S)	University of South Carolina (Columbia, South Carolina)
INVENTOR(S)	Ifat Jahangir (Hillsboro, Oregon); Goutam Koley (Anderson, South Carolina); MVS Chandrashekhar (Columbia, South Carolina)
ABSTRACT	Methods of synthesis and fabrication of a transition metal dichalcogenide (TMD) structures are disclosed. A method can include first patterning a transition metal (TM) on a substrate and placing the substrate in a process chamber. Oxygen can be applied to the transition metal on the substrate and a mixture of highly reactive transition metal oxides can be formed and simultaneously thinned down by sublimation. Finally, a chalcogen can be applied to the substrate and a transition metal dichalcogenide structure can be formed.
FILED	Friday, February 02, 2018
APPL NO	15/886911
ART UNIT	2818 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/324 (20130101) H01L 21/02381 (20130101) H01L 21/02488 (20130101) H01L 21/02568 (20130101) Original (OR) Class H01L 21/02614 (20130101) H01L 21/2636 (20130101) H01L 21/76895 (20130101) H01L 29/24 (20130101) H01L 29/778 (20130101) H01L 29/7391 (20130101) H01L 29/7839 (20130101) H01L 29/66742 (20130101) H01L 29/66969 (20130101) H01L 29/78681 (20130101)
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10777901 — Fabry-Perot cavity antenna system having a frequency selective surface

US 10777901	Franklin et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Rhonda R. Franklin (Falcon Heights, Minnesota); Robert Sainati (Bloomington, Minnesota); Chanjoon Lee (Maple Grove, Minnesota); Aditya Dave (Minneapolis, Minnesota)
ABSTRACT	An antenna system may include a source antenna, a frequency selective surface (FSS), and a second antenna or a fluidic channel associated with a housing. In both examples, the FSS has a first side and a second side opposite from the first side. The first side includes horizontally oriented unit cells positioned as multiple columns of unit cells. The first side of the FSS faces the source antenna and is separated from the source antenna by a defined distance. The housing is positioned on the second side of the FSS. In the latter example, the fluidic channel of the housing includes one of air or deionized water. The fluidic channel is positioned on a portion of the second side of the FSS that is opposite to a subset of the horizontally oriented unit cells on the first side of the FSS.
FILED	Thursday, February 07, 2019
APPL NO	16/269957
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 3/245 (20130101) H01Q 13/10 (20130101) H01Q 15/0033 (20130101) Original (OR) Class H01Q 19/108 (20130101) H01Q 21/065 (20130101)
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10778165 — High dynamic range sensing front-end for neural signal recording systems

US 10778165	Chandrakumar et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Hariprasad Chandrakumar (Los Angeles, California); Dejan Markovic (Los Angeles, California)
ABSTRACT	A high dynamic range sensing front-end for bio-signal recording systems in accordance with embodiments of the invention are disclosed. In one embodiment, a bio-signal amplifier includes an input signal, where the input signal is modulated to a predetermined chopping frequency, a first amplifier stage, a parallel-RC circuit connected to the first amplifier stage and configured to generate a parallel-RC circuit output by selectively blocking an offset current, a second amplifier stage connected to the parallel-RC circuit that includes a second input configured to receive the parallel-RC circuit output and generate a second output that is an amplified version of the input signal with ripple-rejection. Further, the bio-signal amplifier can also include an auxiliary path configured for boosting input impedance by pre-charging at least one input capacitor. In addition, the bio-signal amplifier can also include a DC-servo feedback loop that includes an integrator that utilizes a duty-cycled resistor.
FILED	Wednesday, September 30, 2015
APPL NO	15/515562
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/725 (20130101) A61B 5/04004 (20130101) A61B 5/7203 (20130101) A61B 5/7207 (20130101) A61B 5/7225 (20130101) Amplifiers H03F 3/387 (20130101) H03F 3/45475 (20130101) Original (OR) Class H03F 3/45744 (20130101) H03F 2200/168 (20130101) H03F 2200/261 (20130101) H03F 2200/459 (20130101) H03F 2203/45 (20130101) H03F 2203/45514 (20130101) Coding; Decoding; Code Conversion in General H03M 1/48 (20130101)
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National Aeronautics and Space Administration (NASA)

10773786 — Aircraft with strut-braced wing system

US 10773786	Sclafani et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Anthony J. Sclafani (Alta Loma, California); Adam D. Grasch (Santa Monica, California); Christopher K. Droney (Long Beach, California); Neal A. Harrison (Lake Forest, California)
ABSTRACT	An aircraft that comprises a body, a wing, and a strut. The wing is coupled to and extends from the body. The wing comprises a wing inboard end portion, a wing outboard end portion, opposite the wing inboard end portion, and an intermediate portion between the wing inboard end portion and the wing outboard end portion. The strut comprises a strut inboard end portion and a strut outboard end portion. The strut inboard end portion is coupled to and extends from the body and the strut outboard end portion is coupled to and extends from the intermediate portion of the wing. The strut outboard end portion of the strut is configured to generate a download acting on the strut outboard end portion of the strut when the aircraft is in flight.
FILED	Tuesday, June 06, 2017
APPL NO	15/614834
ART UNIT	3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Aeroplanes; Helicopters B64C 1/26 (20130101) Original (OR) Class B64C 3/14 (20130101) B64C 3/16 (20130101)
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10773831 — Instrument lander utilizing a CubeSat platform for in situ exploration of asteroids and comets

US 10773831	Wang et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	University of Southern California (Los Angeles, California)
ASSIGNEE(S)	University of Southern California (Los Angeles, California)
INVENTOR(S)	Joseph Jiong Wang (Rancho Palos Verdes, California); Brian Parke Franz (Los Angeles, California); Michael Gruntman (Rolling Hills Estates, California)
ABSTRACT	Methods, systems, and apparatus for designing, constructing and using instrument landers for in situ exploration of small solar system bodies, such as asteroids and comets. In one aspect, a lander includes a CubeSat-style platform; instrument packaging, wherein the CubeSat-style platform and the instrument packaging are configured and arranged for an uncontrolled descent, hopping landing on a surface of a body in a solar system, where a descending trajectory for the lander is designed based on gravitational force and solar radiation, with no lander-based propulsion; and a mobility mechanism configured and arranged to self-orient the lander on the surface of the body in the solar system.
FILED	Wednesday, June 28, 2017
APPL NO	15/636382
ART UNIT	3643 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/105 (20130101) Original (OR) Class B64G 1/244 (20190501) B64G 1/645 (20130101) B64G 2001/1071 (20130101)
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10774407 — Nickel titanium alloys, methods of manufacture thereof and article comprising the same

US 10774407	Manuel
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
INVENTOR(S)	Michele Viola Manuel (Gainesville, Florida)
ABSTRACT	Disclosed herein is a shape memory alloy comprising 45 to 50 atomic percent nickel; and 1 to 30 atomic percent of at least one metalloid selected from the group consisting of germanium, antimony, zinc, gallium, tin, and a combination of one or more of the foregoing metalloids, with the remainder being titanium. The shape memory alloy may further contain aluminum. Disclosed herein too is a method of manufacturing the shape memory alloy.
FILED	Monday, June 20, 2016
APPL NO	15/737339
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Alloys C22C 1/02 (20130101) C22C 30/04 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/006 (20130101) Original (OR) Class C22F 1/10 (20130101)
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10774682 — Advanced high temperature and fatigue resistant environmental barrier coating bond coat systems for SiC/SiC ceramic matrix composites

US 10774682	Zhu et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	U.S.A. as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S)	The United States of America as Represented by the Administrator of National Aeromautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Dongming Zhu (Westlake, Ohio); Janet B. Hurst (Columbia Station, Ohio)
ABSTRACT	Advanced environmental barrier coating bond coat systems with higher temperature capabilities and environmental resistance are disclosed. These bond coat systems can be applied to ceramic substrates such as SiC/SiC ceramic matrix composite substrates, and can provide protection from extreme temperature, mechanical loading and environmental conditions, such as in high temperature gas turbines. Example bond coat systems can include either an advanced silicon/silicide component, an oxide/silicate component, or a combination thereof.
FILED	Friday, June 21, 2013
APPL NO	13/923450
ART UNIT	1784 — Miscellaneous Articles, Stock Material
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/565 (20130101) C04B 35/806 (20130101) C04B 41/009 (20130101) C04B 41/009 (20130101) C04B 41/87 (20130101) C04B 41/5024 (20130101) C04B 41/5042 (20130101) C04B 41/5042 (20130101) C04B 41/5044 (20130101) C04B 41/5044 (20130101) C04B 41/5044 (20130101) C04B 41/5096 (20130101) C04B 41/5096 (20130101) Alloys C22C 29/18 (20130101) C22C 32/0078 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/42 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/005 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 428/264 (20150115)
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10774789 — Methods and systems for restartable, hybrid-rockets

US 10774789	Whitmore et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Stephen Whitmore (Logan, Utah); Anthony Marc Bulcher (Logan, Utah); Zachary Lewis (Logan, Utah); Nathan Inkley (Hewitt, Texas)
ASSIGNEE(S)	Utah State University (Logan, Utah)
INVENTOR(S)	Stephen Whitmore (Logan, Utah); Anthony Marc Bulcher (Logan, Utah); Zachary Lewis (Logan, Utah); Nathan Inkley (Hewitt, Texas)
ABSTRACT	Embodiments of the present invention are directed to various devices, systems and methods of providing a restartable, hybrid-rocket system that uses Acrylonitrile Butadiene Styrene (ABS) and compressed air containing oxygen levels up to 40% as a propellant. Alternatively, embodiments of the present invention includes restartable hybrid rocket system that uses a heterogeneous matrix of ABS and a solid oxidizing agent in addition to compressed air as a propellant. When the ABS is exposed to an electrical potential field, the electrical field's effect on the ABS produces localized arcing between multiple layers of the ABS resulting in joule heating and pyrolysis of the ABS. The pyrolysis produces spontaneous combustion of the ABS once the oxidizer flow provides a local oxygen partial pressure greater than two atmospheres at the surface of the ABS.
FILED	Friday, March 22, 2019
APPL NO	16/362430
ART UNIT	3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 31/02 (20130101) C06B 33/00 (20130101) C06B 45/10 (20130101) Jet-propulsion Plants F02K 9/72 (20130101) Original (OR) Class F02K 9/94 (20130101) F02K 9/95 (20130101)
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10775537 — System and method for remote sensing for a target

US 10775537	MacDonnell et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	U.S.A. AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
INVENTOR(S)	David G. MacDonnell (Yorktown, Virginia); Wenbo Sun (Yorktown, Virginia); Yongxiang Hu (Yorktown, Virginia)
ABSTRACT	A remote sensing system includes a primary beam configured to carry orbital angular momentum and characterized by a mode number (m), with the mode number (m) being a non-zero integer. The primary beam is configured to be directed at a target. A photon sieve is configured to receive a secondary beam emanating from the target. The secondary beam at least partially includes a portion of the primary beam. The photon sieve includes a plurality of holes forming one or more respective spiral patterns. The quantity of the respective spiral patterns in the photon sieve corresponds to the mode number (m) of the primary beam. The plurality of holes may be configured to have a minimum diameter such that the minimum diameter is greater than a predefined wavelength of the primary beam. The respective spiral patterns extend between a respective first hole and a respective final hole.
FILED	Tuesday, March 20, 2018
APPL NO	15/926556
ART UNIT	3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) G01N 21/55 (20130101) G01N 2021/1793 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4816 (20130101) G01S 17/89 (20130101) Optical Elements, Systems, or Apparatus G02B 5/005 (20130101) G02B 5/188 (20130101) Original (OR) Class
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10775679 — Coherent optical transistor

US 10775679	Krainak
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Michael A. Krainak (Fulton, Maryland)
ABSTRACT	The present invention relates to a coherent optical transistor device including: first and second coherent optical laser beams from a laser source; wherein the first beam has a relatively higher power/energy than the second beam of at least 2:1; and a permanent sub-wavelength structure in a unitary section into which the first and second beams enter, which permanently modifies a refractive index in both transverse and longitudinal directions; wherein every transverse spatial grating Fourier component in the sub-wavelength structure is phase-shifted by 90 degrees (pi/2) from each of corresponding Fourier components of a spatial interference of the first and second optical beams; and a refractive index profile in the unitary structure in the longitudinal direction is permanently modified, leading to a complete transfer of energy from the first to the second optical beam, resulting in a gain mechanism that results in an amplified signal beam and an inverted signal beam.
FILED	Wednesday, August 22, 2018
APPL NO	16/109472
ART UNIT	2872 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 5/1809 (20130101) G02B 5/1814 (20130101) G02B 5/1857 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 3/026 (20130101) Original (OR) Class G02F 2201/06 (20130101) G02F 2201/30 (20130101) G02F 2203/13 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/0657 (20130101)
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10776713 — Classification of highly-skewed data

US 10776713	Kumar et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC) National Science Foundation (NSF)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Vipin Kumar (Minneapolis, Minnesota); Varun Mithal (Minneapolis, Minnesota); Guruprasad Nayak (Minneapolis, Minnesota); Ankush Khandelwal (Minneapolis, Minnesota)
ABSTRACT	A method for identifying highly-skewed classes using an imperfect annotation of every instance together with a set of features for all instances. The imperfect annotations designate a plurality of instances as belonging to the target rare class and others to the majority class. First, a classifier is trained on the set of features using the imperfect annotation as supervision, to designate each instance to either the rare class or majority class. A combination of the predictions from the trained classifier and the imperfect annotations is then used to classify each instance to either the rare class or majority class. In particular, an instance is classified to the rare class only when both the trained classifier and the imperfect annotation classify the instance to the rare class. Finally, for each instance assigned as a rare class instance by the combination stage, all instances in its neighborhood are re-classified as either rare class or majority class.
FILED	Monday, April 25, 2016
APPL NO	15/137603
ART UNIT	2122 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class
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10778355 — Frequency division multiplexing scheme for phasing synthetic aperture radars and receivers

US 10778355	Rincon et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Rafael Rincon (Greenbelt, Maryland); Dee-Pong Daniel Lu (Greenbelt, Maryland)
ABSTRACT	A frequency division multiplexing system includes a processor, a first digital to analog converter (DAC) for generating a local oscillator signal, a second DAC for generating a chirp signal, and a plurality of electronic elements, each having a transmit signal mixer for combining the local oscillator and chirp signals, and a transceiver configured to transmit the combined local oscillator and chirp signals, where the processor may be configured to operate the first DAC and second DAC to vary frequencies of the local oscillator and chirp signals such that the combination of the local oscillator and chirp signals results in a constant center frequency with a varying phase.
FILED	Wednesday, June 05, 2019
APPL NO	16/432357
ART UNIT	2478 — Multiplex and VoIP
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/034 (20130101) G01S 13/90 (20130101) G01S 2013/0245 (20130101) Multiplex Communication H04J 1/08 (20130101) Original (OR) Class
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Department of Agriculture (USDA)

10772924 — Therapeutic use of chardonnay seed products

US 10772924	Arvik et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	SONOMACEUTICALS, LLC (Santa Rosa, California); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia)
ASSIGNEE(S)	SONOMACEUTICALS, LLC (Santa Rosa, California); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia)
INVENTOR(S)	Torey James Arvik (Santa Rosa, California); Rebecca Susan Lipson (Santa Rosa, California); Wallace H. Yokoyama (Albany, California)
ABSTRACT	The present disclosure relates to health benefits of Chardonnay seed products.
FILED	Friday, September 28, 2018
APPL NO	16/145595
ART UNIT	1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 36/87 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/10 (20180101)
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10772953 — Recombinant spike ectodomain proteins, compositions, vectors, kits, and methods for immunizing against avian infectious bronchitis virus

US 10772953	van Santen et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Auburn University (Auburn, Alabama)
ASSIGNEE(S)	Auburn University (Auburn, Alabama)
INVENTOR(S)	Vicky L. van Santen (Auburn, Alabama); Haroldo E. Toro (Auburn, Alabama)
ABSTRACT	Disclosed are recombinant spike ectodomain proteins, compositions, vectors, kits, and methods for inducing an immune response against avian infectious bronchitis virus (IBV). In particular, the recombinant proteins, compositions, vectors, kits, and methods relate to, include, and/or utilize a soluble, multimerized form of the (IBV) spike (S) protein ectodomain. The recombinant proteins, compositions, vectors, kits, and methods may be utilized to immunize poultry against disease associated with IBV infection or to protect poultry from IBV infection.
FILED	Thursday, August 09, 2018
APPL NO	16/059803
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/552 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) C07K 14/165 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20022 (20130101) C12N 2770/20034 (20130101)
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10774334 — Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety

US 10774334	Curtiss, III et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Dental and Craniofacial Research (NIDCR) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	The Arizona Board of Regents for and on Behalf of Arizona State University (Scottsdale, Arizona); The Washington University (St. Louis, Missouri)
ASSIGNEE(S)	Arizona Broad of Regents on Behalf of Arizona State University (Scottsdale, Arizona); The Washington University (St. Louis, Missouri)
INVENTOR(S)	Roy Curtiss, III (Gainesville, Florida); Shifeng Wang (Gainesville, Florida); Soo-Young Wanda (Gainesville, Florida); Wei Kong (Phoenix, Arizona)
ABSTRACT	The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
FILED	Thursday, December 05, 2019
APPL NO	16/704032
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 39/00 (20130101) A61K 2035/11 (20130101) A61K 2039/522 (20130101) A61K 2039/523 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/36 (20130101) C12N 15/74 (20130101) Original (OR) Class
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10774337 — Method to develop high oleic acid soybeans using conventional soybean breeding techniques

US 10774337	Bilyeu et al.
FUNDED BY	Department of Agriculture (USDA) Agricultural Research Service (ARS)
APPLICANT(S)	The Curators of the University of Missouri (Columbia, Missouri); The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)	The Curators of the University of Missouri (Columbia, Missouri); The United States of America as Represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S)	Kristin D. Bilyeu (Columbia, Missouri); James Grover Shannon (Kennett, Missouri); Jeong-Dong Lee (Daegu, South Korea); Anh Tung Pham (Columbia, Missouri)
ABSTRACT	The present invention is directed to a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, the present invention is directed to seeds from said plants with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention is directed to plants where the plants exhibit elevated levels of oleic acid.
FILED	Tuesday, September 11, 2018
APPL NO	16/127366
ART UNIT	1662 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/00 (20130101) A01H 5/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8247 (20130101) Original (OR) Class
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National Security Agency (NSA)

10776087 — Sequence optimizations in a high-performance computing environment

US 10776087	Zhang
FUNDED BY	Department of Energy (DOE) National Security Agency (NSA)
APPLICANT(S)	INTEL CORPORATION (Santa Clara, California)
ASSIGNEE(S)	INTEL CORPORATION (Santa Clara, California)
INVENTOR(S)	Yongzhi Zhang (Wayland, Massachusetts)
ABSTRACT	Embodiments are directed to techniques to determine dataflow graph instructions comprising one or more pick/switch instruction pairs and generate a reverse static single assignment graph based on the dataflow graph instructions, the reverse static single assignment graph comprising strongly connected components, each of the strongly connected components associated with at least one of the one or more pick/switch instruction pairs. Embodiments also include traversing the reverse static single assignment graph depth-first, and replace pick/switch instructions associated with strongly connected components having configuration values with compound instructions.
FILED	Monday, June 25, 2018
APPL NO	16/017000
ART UNIT	2193 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 8/31 (20130101) G06F 8/44 (20130101) G06F 8/433 (20130101) Original (OR) Class G06F 8/443 (20130101) G06F 8/4432 (20130101)
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10778229 — Logic gates with flux solitons

US 10778229	Osborn et al.
FUNDED BY	National Security Agency (NSA)
APPLICANT(S)	The Government of the United States as represented by the Director, National Security Agency (Ft. George G. Meade, Maryland)
ASSIGNEE(S)	U.S. Government as represented by the Director, National Security Agency (Washington, District of Columbia)
INVENTOR(S)	Kevin D. Osborn (Clarksville, Maryland); Waltraut Wustmann (Dunedin, New Zealand)
ABSTRACT	A CNOT gate includes a clock line, splitter, and first and second store-and-launch gates (SNLs) to each output a fluxon in accordance with a clock fluxon and polarities of an input fluxon and the clock fluxon. The CNOT gate also includes first and second IDSN gates. When one fluxon input is received, the IDSN gate outputs one fluxon in accordance with a polarity of the fluxon input. When two fluxon inputs are received, the IDSN gate outputs two fluxons in accordance with an inverse polarity of the fluxon inputs. The CNOT gate also includes first and second NOT gates to receive a fluxon output from the first IDSN gate and output a fluxon of opposite polarity, and a third NOT gate to receive a fluxon output from the second IDSN gate and output a fluxon of opposite polarity.
FILED	Monday, March 02, 2020
APPL NO	16/806391
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pulse Technique H03K 19/20 (20130101) H03K 19/195 (20130101) Original (OR) Class
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Central Intelligence Agency (CIA)

10778432 — End-to-end encryption during a secure communication session

US 10778432	Leavy et al.
FUNDED BY	Central Intelligence Agency (CIA)
APPLICANT(S)	Wickr Inc. (San Francisco, California)
ASSIGNEE(S)	Wickr Inc. (Pleasanton, California)
INVENTOR(S)	Thomas Michael Leavy (River Edge, New Jersey); Joël Alwen (Vienna, Austria)
ABSTRACT	The present application describes a method, system, and non-transitory computer-readable medium for end-to-end encryption during a secure communication session. According to the present disclosure, a first device initializes a secure communication session with at least one second device. Initializing the secure communication session includes transmitting an invitation to a secure communication session to the at least one second device. The first device subsequently receives the token from the at least one second device and validates the token. When the token is invalid, the first devices terminates the secure communication session. However, when the token is valid, the first device performs a three-way handshake with the at least one second device to negotiate a first encryption key and a second encryption key. The first encryption key is used to encrypt communication data transmitted by the first device and the second encryption key is used to decrypt communication data received from the at least one second device.
FILED	Wednesday, November 08, 2017
APPL NO	15/806465
ART UNIT	2437 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 9/14 (20130101) H04L 9/32 (20130101) Original (OR) Class H04L 63/0428 (20130101)
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Department of Commerce (DOC)

10778436 — Active security token with security phantom for porting a password file

US 10778436	Dray, Jr.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)	GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Gaithersburg, Maryland)
INVENTOR(S)	James F. Dray, Jr. (Myersville, Maryland)
ABSTRACT	An active security token includes: a sentry that controls access to token data disposed on the active security token through verification of user authentication data; the token data including: reference authentication data for verification of user authentication data; and a security phantom including a password file, the security phantom being a public key certificate or a biometric template.
FILED	Wednesday, August 23, 2017
APPL NO	15/661214
ART UNIT	2438 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3231 (20130101) Original (OR) Class H04L 9/3247 (20130101) H04L 9/3263 (20130101) H04L 63/083 (20130101)
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Department of Homeland Security (DHS)

10776463 — Active authentication of users

US 10776463	Stavrou et al.
FUNDED BY	Department of Homeland Security (DHS) Science and Technology Directorate (DHS-ST) Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	KRYPTOWIRE LLC (McLean, Virginia)
ASSIGNEE(S)	KRYPTOWIRE LLC (McLean, Virginia)
INVENTOR(S)	Angelos Stavrou (Fairfax, Virginia); Rahul Murmuria (Burke, Virginia); Ryan Johnson (Warrenton, Virginia); Daniel Barbara (Reston, Virginia)
ABSTRACT	Embodiments herein disclose a method and system for authenticating users of an electronic device. In an example, data pertaining to a user of the electronic device is collected for authentication. The data is data indicative of an interaction behavior of the user with the electronic device. A deviation of the collected data from a behavior model of the user is checked. To generate the behavior model, data from multiple users is collected to create the behavior model corresponding to each of the users, each behavior model is indicative of data uncommon between the user corresponding to the behavior model and other users in the plurality of users to separate the user corresponding to the behavior model from other users in the multiple users. Further, an access control policy is enforced on the electronic device, based on the deviation of the collected data from the behavior model of the user.
FILED	Monday, March 11, 2019
APPL NO	16/298829
ART UNIT	2434 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/32 (20130101) G06F 21/316 (20130101) Original (OR) Class
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Small Business Administration (SBA)

10773010 — Subcutaneous vascular access ports and related systems and methods

US 10773010	Phillips et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Advent Access Pte. Ltd. (Singapore, Singapore)
ASSIGNEE(S)	Advent Access Pte. Ltd. (Singapore, Singapore)
INVENTOR(S)	Christopher M. Phillips (Salt Lake City, Utah); Nathaniel P. Young (Salt Lake City, Utah); Trent J. Perry (Kaysville, Utah); Duane D. Blatter (Salt Lake City, Utah); Mark A. Crawford (Sandy, Utah); G. Doug Smith (Sandy, Utah); Steven Johnson (Lehi, Utah)
ABSTRACT	Ports for accessing a vessels within a patient include passageways that can guide needles or other access devices directly into the vessels. The ports can be implanted subcutaneously within a patient. Some ports may be used in the creation and use of vascular access buttonholes.
FILED	Friday, March 16, 2018
APPL NO	15/923854
ART UNIT	3781 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 17/0057 (20130101) A61B 17/3423 (20130101) A61B 2017/00641 (20130101) A61B 2017/00654 (20130101) A61B 2017/3425 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/3653 (20130101) Original (OR) Class A61M 1/3659 (20140204) A61M 1/3661 (20140204) A61M 39/0208 (20130101) A61M 2039/0223 (20130101) A61M 2039/0226 (20130101) A61M 2039/0238 (20130101) A61M 2205/0238 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10774431 — Ion-conducting membranes

US 10774431	Masel et al.
FUNDED BY
APPLICANT(S)	Dioxide Materials, Inc. (Boca Raton, Florida)
ASSIGNEE(S)	Dioxide Materials, Inc. (Boca Raton, Florida)
INVENTOR(S)	Richard I. Masel (Boca Raton, Florida); Syed Dawar Sajjad (Boca Raton, Florida); Qingmei Chen (Savoy, Illinois)
ABSTRACT	An anion-conducting polymeric membrane comprises vinylbenzyl-R_sand a substituted ethene. R_sis a positively charged cyclic amine group. The total weight of the vinylbenzyl-R_sgroups is greater than 15% of the total weight of the membrane. In a preferred embodiment, the membrane is a Helper Membrane that increases the faradaic efficiency of an electrochemical cell into which the membrane is incorporated, and also allows product formation at lower voltages than in cells without the Helper Membrane.
FILED	Sunday, November 12, 2017
APPL NO	15/810106
ART UNIT	1764 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/08 (20130101) B01J 31/0281 (20130101) B01J 31/0282 (20130101) B01J 31/0284 (20130101) B01J 41/13 (20170101) B01J 41/14 (20130101) B01J 2231/625 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 212/08 (20130101) C08F 226/06 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 2339/04 (20130101) Compositions of Macromolecular Compounds C08L 39/04 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 13/08 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/1653 (20130101) H01M 8/0239 (20130101) H01M 8/1023 (20130101) H01M 2008/1095 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10774674 — Set screw gap control between fixed and variable vanes

US 10774674	Dyer
FUNDED BY
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	David M. Dyer (Glastonbury, Connecticut)
ABSTRACT	A variable vane adjustment system for a gas turbine engine including: a vane platform having a recess, a vane opening within the recess, and a set screw opening originating at a first wall of the recess and extending into the vane platform; a trunnion carrier having a base portion located at least partially within the recess, a bushing attached to the base portion, and an orifice that extends through the base portion and bushing, wherein the orifice is aligned with the vane opening; a variable vane having a vane stem, the vane stem extending through the vane opening and the orifice; and a set screw located at least partially within the set screw opening, the set screw being configured to longitudinally traverse the set screw opening as the set screw is rotated, wherein the set screw is configured to move the trunnion carrier and variable vane.
FILED	Thursday, September 13, 2018
APPL NO	16/130042
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/041 (20130101) F01D 9/042 (20130101) F01D 17/162 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/60 (20130101) F05D 2240/12 (20130101) F05D 2240/80 (20130101) F05D 2260/30 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10776928 — Efficient egomotion estimation using patch-based projected correlation

US 10776928	Horvath et al.
FUNDED BY
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Andras Horvath (Budapest, Hungary); Shankar Rao (Agoura Hills, California)
ABSTRACT	A method for improving computational efficiency for egomotion estimation includes detecting a pair of consecutive images, and estimating a rotation angle and a two dimensional translation vector that best models the motion between the image frames. The pair of images are each divided into overlapping image patches, and then an efficient projected correlation approach is used to estimate a local two dimensional translation vector for each image patch. The translation vectors from all the patches form a vector field, and then trimmed-mean method is used to robustly and efficiently estimate the rotation angle and the two dimensional translation that best models the egomotion of the detector, which may be a camera.
FILED	Tuesday, August 06, 2019
APPL NO	16/532970
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/13 (20170101) G06T 7/20 (20130101) Original (OR) Class G06T 7/174 (20170101) G06T 2207/20021 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10778176 — CMOS Guanella balun

US 10778176	Pierce et al.
FUNDED BY
APPLICANT(S)	RAYTHEON COMPANY (Waltham, Massachusetts)
ASSIGNEE(S)	Raytheon Company (Waltham, Massachusetts)
INVENTOR(S)	Richard G. Pierce (Waltham, Massachusetts); Robert S. Isom (Waltham, Massachusetts); Brandon W. Pillans (Waltham, Massachusetts); Mikel White (Waltham, Massachusetts); David D. Heston (Waltham, Massachusetts); John G. Heston (Waltham, Massachusetts)
ABSTRACT	Guanella topology balun/unun impedance transformer contains cascaded, i.e., series-coupled, coils of different sizes implemented in RF CMOS technology. The cascading of differently-sized coils provides for a large resonance-free operating bandwidth. The shunt inductive loading maximizes low frequency performance.
FILED	Thursday, November 29, 2018
APPL NO	16/203763
ART UNIT	2843 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 41/041 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 5/10 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/38 (20130101) Original (OR) Class H03H 7/42 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10778423 — Reusable fuzzy extractor based on the learning-with-error assumption secure against quantum attacks

US 10778423	Cho et al.
FUNDED BY
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Chongwon Cho (Los Angeles, California); Karim El Defrawy (Santa Monica, California); Daniel C. Apon (College Park, Maryland); Jonathan Katz (Silver Spring, Maryland)
ABSTRACT	Described is a system for biometric based security. The system converts biometric data into a cryptographic key using a reusable fuzzy extractor process. The reusable fuzzy extractor process comprises a generation process and a reconstruction process. The generation process takes as input a public parameter and a first biometric input and outputs a public helper string and a first random string. The reconstruction process takes as input a public helper string and a second biometric input and outputs a second random string. The reusable fuzzy extractor process is reusable such that multiple public helper strings do not reveal any information about the first biometric input and the first random string. Secured data is unlocked by applying the cryptographic key for biometric security of access to secured data.
FILED	Tuesday, May 15, 2018
APPL NO	15/980722
ART UNIT	2437 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 9/002 (20130101) H04L 9/0866 (20130101) Original (OR) Class H04L 9/3231 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10778652 — Secure computational workflows

US 10778652	Martin et al.
FUNDED BY
APPLICANT(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Patrick J. Martin (Falls Church, Virginia); Brent C. Baker (Vadnais Heights, Minnesota); Collin T. Blakley (Vienna, Virginia); Gregory T. Eakman (Billerica, Massachusetts); Robert B. Ross (Fairfax, Virginia)
ABSTRACT	Techniques are disclosed for providing a secure computational platform that facilitates collaboration of assets from different asset providers without exposure of the assets to threats. The assets may be in the form of tools, models, simulations, and other computational assets, which can be used, for example, to perform trade studies. The secure computational platform provides for integration of the assets in a workflow, while protecting the assets during construction and execution of the workflow. In some instances, each asset in the workflow is executed in an IT infrastructure of the asset provider to which the asset belongs.
FILED	Tuesday, July 31, 2018
APPL NO	16/050253
ART UNIT	2495 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101) H04L 63/062 (20130101) H04L 63/0428 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, September 15, 2020.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2020/fedinvent-patents-20200915.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

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