FedInvent™ Patents

Patent Details for Tuesday, November 17, 2020

This page was updated on Monday, March 27, 2023 at 06:13 AM GMT

Department of Health and Human Services (HHS)

10835110 — Apparatus and method for facilitating at least partial overlap of dispersed ration on at least one sample

US 10835110	Tearney et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Guillermo J. Tearney (Cambridge, Massachusetts); Brett Eugene Bouma (Quincy, Massachusetts); Dvir Yelin (Haifa, Israel); Dongkyun Kang (Cambridge, Massachusetts)
ABSTRACT	Exemplary embodiments of apparatus and method according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. The exemplary apparatus can include a first arrangement having at least two wave-guides which can be configured to provide there through at least two respective electro-magnetic radiations with at least partially different wavelengths from one another. The exemplary apparatus can also include a dispersive second arrangement structured to receive the electro-magnetic radiations and forward at least two dispersed radiations associated with the respective electro-magnetic radiations to at least one section of the structure. The wave-guide(s) can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate at least partially overlap of the dispersed radiations on the structure. In addition, another arrangement can be provided which can include at least two further wave-guides which can be configured to receive the electro-magnetic radiations from the dispersive arrangement. Each of the further wave-guides can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate a receipt of a different one of the such electro-magnetic radiations as a function of wavelengths thereof.
FILED	Tuesday, January 19, 2016
APPL NO	15/000824
ART UNIT	2886 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/04 (20130101) A61B 1/00172 (20130101) Original (OR) Class A61B 5/0062 (20130101) A61B 5/0066 (20130101) A61B 5/0075 (20130101) A61B 5/0084 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/18 (20130101) G01J 3/0218 (20130101) G01J 3/0256 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/4795 (20130101) Optical Elements, Systems, or Apparatus G02B 23/2423 (20130101) G02B 23/2469 (20130101)
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10835111 — Three-dimensional imaging using swept, confocally aligned planar excitation with an image relay

US 10835111	Hillman
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Elizabeth Marjorie Clare Hillman (New York, New York)
ABSTRACT	The disclosed subject matter includes devices and systems for extending the imaging capability of swept, confocally aligned planar excitation (SCAPE) microscopes to in vivo applications. In embodiments, the SCAPE microscope can be implemented as an endoscopic or laparoscopic inspection instrument.
FILED	Monday, July 10, 2017
APPL NO	16/314752
ART UNIT	2482 — Recording and Compression
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/07 (20130101) A61B 1/00172 (20130101) A61B 1/00174 (20130101) Original (OR) Class A61B 1/00197 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0087 (20130101) G02B 21/006 (20130101) G02B 21/0028 (20130101) G02B 21/0048 (20130101) G02B 21/0076 (20130101) Pictorial Communication, e.g Television H04N 5/2251 (20130101) H04N 2005/2255 (20130101)
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10835119 — Compact telescope configurations for light scanning systems and methods of using the same

US 10835119	Izatt et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Joseph A. Izatt (Durham, North Carolina); Francesco Larocca (Durham, North Carolina); Theodore Dubose (Durham, North Carolina); Derek Nankivil (Durham, North Carolina)
ABSTRACT	Compact telescope configurations for light scanning systems and related methods are disclosed. According to an aspect, a system for imaging or relaying an image of an object includes a first optical element having a first focal length f₁for imaging or relaying an image of an object at the distance f₁from the first optical element. The system also includes a second optical element having a second focal length f₂for receiving an image of the object from the first optical element and for focusing an output of the image at the distance f₂from the second optical element on a side that opposes the first optical element. The first optical element and the second optical element are separated by a distance of approximately [Formula I], wherein r is the finite radius of curvature of the wavefront of light located at the object or image of the object.
FILED	Friday, February 05, 2016
APPL NO	15/547547
ART UNIT	2872 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/13 (20130101) A61B 3/102 (20130101) A61B 3/1025 (20130101) A61B 3/1208 (20130101) Original (OR) Class
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10835139 — Method to determine wavefront vector flow-field and vorticity from spatially-distributed recordings

US 10835139	Rappel et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Wouter-Jan Rappel (San Diego, California); David Vidmar (San Diego, California)
ABSTRACT	Methods and systems are provided for determination and mapping of vector fields which characterize wavefront motion through space and time. The inventive methods and systems utilize data from spatially-distributed locations and maps wavefront vector flow fields in an entirely automated manner. These maps can be used to characterize the activation as planar, centrifugal, or rotational. Further, the strength of rotation or divergence is determined from these fields and can be used to select spatial points of significantly increased rotational or focal activity. As applied to electrophysiological data recorded during heart rhythm disorders in patients, the inventive method provides a means of visual interpretation of complex activation maps. The information related to the strength and location of rotation and centrifugal activity during episodes of arrhythmia can guide therapies designed to treat such disorders.
FILED	Friday, March 24, 2017
APPL NO	16/087560
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0006 (20130101) A61B 5/0022 (20130101) A61B 5/0422 (20130101) A61B 5/0452 (20130101) A61B 5/04011 (20130101) Original (OR) Class A61B 5/4836 (20130101) A61B 5/6858 (20130101) A61B 5/6869 (20130101) A61B 5/7207 (20130101) A61B 5/7278 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/368 (20130101)
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10835159 — Systems and methods for functional imaging of the placenta

US 10835159	Schabel et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	Matthias Schabel (Portland, Oregon); Antonio Frias (Portland, Oregon); Christopher Kroenke (Portland, Oregon)
ASSIGNEE(S)	Oregon Health and Science University (Portland, Oregon)
INVENTOR(S)	Matthias Schabel (Portland, Oregon); Antonio Frias (Portland, Oregon); Christopher Kroenke (Portland, Oregon)
ABSTRACT	A method or system for imaging and quantifying placental blood perfusion using magnetic resonance image. The method or system provides a noninvasive means of assessing placental function and oxygenation from T₂* images without the administration of an exogenous contrast agent. The method or system provides quantitative information regarding the number and spatial distribution of perfusion domains which subdivide the placenta into functional units where oxygen transport occurs, along with estimates of fetal oxyhemoglobin concentration, descriptors of placental oxygen reserve, and parameters representing the facility with which oxygen transport from the maternal to fetal vasculature occurs.
FILED	Friday, September 23, 2016
APPL NO	15/274718
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/0263 (20130101) A61B 5/4343 (20130101) A61B 5/4362 (20130101) A61B 5/7278 (20130101) A61B 5/14542 (20130101) Original (OR) Class A61B 5/14546 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/5608 (20130101) G01R 33/5616 (20130101) G01R 33/56366 (20130101) Electric Digital Data Processing G06F 30/20 (20200101)
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10835167 — Systems and methods for using mobile and wearable video capture and feedback plat-forms for therapy of mental disorders

US 10835167	Voss et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Catalin Voss (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Catalin Voss (Stanford, California)
INVENTOR(S)	Catalin Voss (Stanford, California); Nicholas Joseph Haber (Palo Alto, California); Dennis Paul Wall (Palo Alto, California); Aaron Scott Kline (Saratoga, California); Terry Allen Winograd (Stanford, California)
ABSTRACT	Behavioral and mental health therapy systems in accordance with several embodiments of the invention include a wearable camera and/or a variety of sensors (accelerometer, microphone, among various other) connected to a computing system including a display, audio output, holographic output, and/or vibrotactile output to automatically recognize social cues from images captured by at least one camera and provide this information to the wearer via one or more outputs such as (but not limited to) displaying an image, displaying a holographic overlay, generating an audible signal, and/or generating a vibration.
FILED	Monday, May 08, 2017
APPL NO	15/589877
ART UNIT	2669 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0002 (20130101) A61B 5/0036 (20180801) A61B 5/165 (20130101) Original (OR) Class A61B 5/0205 (20130101) A61B 5/681 (20130101) A61B 5/742 (20130101) A61B 5/1114 (20130101) A61B 5/1126 (20130101) A61B 5/1128 (20130101) A61B 5/1176 (20130101) A61B 5/4836 (20130101) A61B 5/6803 (20130101) A61B 5/7405 (20130101) A61B 5/7455 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/70 (20180101) G16H 30/40 (20180101) G16H 40/63 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101)
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10835184 — Device for neuroprosthetics with autonomous tunable actuators

US 10835184	Muthuswamy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Jitendran Muthuswamy (Chandler, Arizona); Sivakumar Palaniswamy (Tempe, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Jitendran Muthuswamy (Chandler, Arizona); Sivakumar Palaniswamy (Tempe, Arizona)
ABSTRACT	A microelectromechanical device and method for neuroprosthetics comprises microactuators and microelectrodes. The microelectrodes are to be positioned in a nerve bundle and bonded with the microactuators through an interconnect. The position of each of the microactuators can be individually tuned through control signals so that the microelectrodes are implanted at desired positions in the nerve bundle. The control signals are transmitted to the microactuators and generated with a open-loop or closed-loop control scheme that uses signals acquired by the microelectrodes from the nerve bundle as feedback.
FILED	Friday, April 22, 2016
APPL NO	15/136126
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/0031 (20130101) A61B 5/202 (20130101) A61B 5/0538 (20130101) A61B 5/04001 (20130101) A61B 5/6877 (20130101) Original (OR) Class A61B 5/6886 (20130101) A61B 2562/028 (20130101) A61B 2562/043 (20130101) A61B 2562/0285 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101)
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10835400 — Apparatus and methods for bidirectional hyperelastic stent covers

US 10835400	Carman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Greg Carman (Los Angeles, California); Daniel S. Levi (Pacific Palisades, California); Mohanchandra Kotekar Panduranga (North Hills, California); Fernando Vinuela (Los Angeles, California); Abdon E. Sepulveda (Los Angeles, California)
ABSTRACT	An apparatus and method for a micro-patterned thin film Nitinol (TFN) that is used as a cover for an expandable stent structure, and has elongation/expansion properties that are configured to match the elongation/expansion properties of the expandable stent structure is presented.
FILED	Thursday, August 16, 2018
APPL NO	16/104034
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/07 (20130101) A61F 2/90 (20130101) A61F 2/91 (20130101) A61F 2/915 (20130101) Original (OR) Class A61F 2002/072 (20130101) A61F 2002/823 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/35 (20130101)
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10835486 — Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates

US 10835486	Ma et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S)	Minglin Ma (Ithaca, New York); Daniel G. Anderson (Farmingham, Massachusetts); Robert S. Langer (Newton, Massachusetts); Omid Veiseh (Cambridge, Massachusetts); Arturo Jose Vegas (Belmont, Massachusetts); Joshua Charles Doloff (Quincy, Massachusetts); Delai Chen (Woburn, Massachusetts); Christian J. Kastrup (British Columbia, Canada)
ABSTRACT	Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
FILED	Thursday, December 15, 2016
APPL NO	15/379718
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) Original (OR) Class A61K 9/4833 (20130101) A61K 9/4866 (20130101) A61K 9/5036 (20130101) A61K 9/5078 (20130101) A61K 9/5089 (20130101) A61K 35/39 (20130101) A61K 45/06 (20130101) A61K 2035/126 (20130101) A61K 2035/128 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/046 (20130101)
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10835513 — Methods and treatments for the learning and memory deficits associated with Noonan syndrome

US 10835513	Silva et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Alcino Silva (Sherman Oaks, California); Yong-Seok Lee (Los Angeles, California); Dan Ehninger (Bonn, Germany)
ABSTRACT	Disclosed herein are methods and compositions for treating learning and memory deficits associated with Noonan Syndrome.
FILED	Friday, June 27, 2014
APPL NO	14/900907
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/22 (20130101) A61K 31/22 (20130101) A61K 31/40 (20130101) A61K 31/40 (20130101) A61K 31/277 (20130101) A61K 31/277 (20130101) A61K 31/366 (20130101) Original (OR) Class A61K 31/366 (20130101) A61K 31/404 (20130101) A61K 31/404 (20130101) A61K 31/505 (20130101) A61K 31/505 (20130101) A61K 31/4418 (20130101) A61K 31/4418 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10835516 — Protective, anti-inflammatory receptor and its use in preservation of mitochondrial function, wound healing and repair

US 10835516	Abadir et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
INVENTOR(S)	Peter M. Abadir (Woodstock, Maryland); Jeremy D. Walston (Baltimore, Maryland)
ABSTRACT	Provided herein is a novel mitochondrial Angiotensin II type 1 and type 2 AT₁R and AT₂R receptor which plays a role in protection of mitochondria against oxidative damage. Evidence from animal studies indicates a role for this receptor in preservation of mitochondria and up-regulation of survival genes, anti-inflammatory action, and improvement of wound healing in the skin and soft tissues. Pharmaceutical compositions for treatment directed to preserving mitochondrial function, anti-inflammation, wound healing and decreasing the signs of aging, as well as medicaments and their use are also provided.
FILED	Thursday, January 15, 2015
APPL NO	14/598105
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/41 (20130101) A61K 31/4178 (20130101) Original (OR) Class A61K 31/4184 (20130101) Peptides C07K 14/705 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/566 (20130101)
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10835518 — Fatty acids as anti-inflammatory agents

US 10835518	Freeman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Bruce A. Freeman (Pittsburgh, Pennsylvania); Francisco J. Schopfer (Pittsburgh, Pennsylvania)
ABSTRACT	Compounds of formula I and their metabolites are potent mediators of an inflammatory response: where a, b, c, d, e, f, V, W, X, Y, R^a, R^b, R^b′, R^c, and R^c′ are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.
FILED	Thursday, January 03, 2019
APPL NO	16/239425
ART UNIT	1629 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/231 (20130101) A61K 31/232 (20130101) A61K 31/421 (20130101) A61K 31/426 (20130101) Original (OR) Class A61K 31/4166 (20130101) A61K 31/4192 (20130101) Technologies for Adaptation to Climate Change Y02A 50/401 (20180101)
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10835519 — Targeting metabolic adaptive responses to chemotherapy

US 10835519	Plas et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Cincinnati (Cincinnati, Ohio)
ASSIGNEE(S)	University of Cincinnati (Cincinnati, Ohio)
INVENTOR(S)	David Plas (Cincinnati, Ohio); Catherine Behrmann (Fairfield, Ohio)
ABSTRACT	Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC1 or upstream or downstream pathway components of S6K1 or mTORC1, in association with administration of at least one inhibitor of PPARα, PPARδ, or PGC1α. In various embodiments, the compound that inhibits S6K1, mTORC1, or upstream or downstream pathway components of S6K1 or mTORC1 is rapamycin, everolimus, temsirolimus, or imatinib. The inhibitor of PPARα, PPARδ, or PGC1α can be an antagonist or an inverse agonist selected from GW6471, GSK3787, GSK0660, and ST247.
FILED	Friday, December 22, 2017
APPL NO	15/851891
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) A61K 31/381 (20130101) A61K 31/421 (20130101) A61K 31/421 (20130101) A61K 31/436 (20130101) Original (OR) Class A61K 31/436 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10835532 — Muscarinic agonists as cognitive enhancers

US 10835532	Messer, Jr. et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The University of Toledo (Toledo, Ohio); The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)	The University of Toledo (Toledo, Ohio); The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	William S. Messer, Jr. (Toledo, Ohio); Michael E. Ragozzino (Chicago, Illinois)
ABSTRACT	Methods of treating a mental condition by administering to a subject in need thereof an effective amount of compound CDD-102A, [5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine] are described.
FILED	Thursday, October 17, 2013
APPL NO	14/056616
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class
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10835546 — App specific BACE inhibitors (ASBIs) and uses thereof

US 10835546	John et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	BUCK INSTITUTE FOR RESEARCH ON AGING (Novato, California)
ASSIGNEE(S)	BUCK INSTITUTE FOR RESEARCH ON AGING (Novato, California)
INVENTOR(S)	Varghese John (Los Angeles, California); Dale E. Bredesen (Los Angeles, California)
ABSTRACT	In certain embodiments APP-specific BACE inhibitors (ASBIs) are provided as well as uses thereof. In certain embodiments methods of preventing delaying the onset of a pre-Alzheimer's condition and/or cognitive dysfunction, and/or ameliorating one or more symptoms of a pre-Alzheimer's condition and/or cognitive dysfunction, or preventing or delaying the progression of a pre-Alzheimer's condition or cognitive dysfunction to Alzheimer's disease are provided where the method involves administering to a subject in need thereof an APP specific BACE inhibitor (ASBI) in an amount sufficient to prevent or delay the onset of a pre-Alzheimer's cognitive dysfunction, and/or to ameliorate one or more symptoms of a pre-Alzheimer's cognitive dysfunction, and/or to prevent or delay the progression of a pre-Alzheimer's cognitive dysfunction to Alzheimer's disease. In certain embodiments the ASBI is a flavonoid (e.g. galangin) or flavonoid progrug (e.g., galangin prodrug).
FILED	Thursday, June 06, 2019
APPL NO	16/433879
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/366 (20130101) A61K 31/7048 (20130101) Original (OR) Class Heterocyclic Compounds C07D 311/24 (20130101) C07D 311/30 (20130101)
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10835549 — Polyplexes

US 10835549	Duvall et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) Non-Profit Organization (NPO) American Heart Association (AHA) National Science Foundation (NSF)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee); The United States as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee); The United States as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Craig Duvall (Nashville, Tennessee); Brian Connor Evans (Bartlett, Tennessee); Colleen Brophy (Nashville, Tennessee); Kyle Hocking (Alpharetta, Georgia)
ABSTRACT	The present disclosure relates to compounds comprising (i) an active agent, wherein the active agent includes a charge at a predetermined pH, (ii) a polymer, wherein the polymer includes an opposite charge than the active agent at the predetermined pH; and (iii) a polyplex comprising the peptide and the polymer electrostatically bond together at the predetermined pH. In some embodiments, the active agent is a peptide, such as a peptide comprising MAPKAP kinase II inhibitory peptide, and in some embodiments the peptide includes a cell-penetrating peptide. In further embodiments, the disclosure provides methods for treating a disease or condition by administering a composition according to the present disclosure to a subject in need thereof.
FILED	Friday, April 11, 2014
APPL NO	14/784017
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/711 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 38/005 (20130101) A61K 38/55 (20130101) A61K 38/55 (20130101) A61K 47/32 (20130101) A61K 47/58 (20170801) A61K 47/6927 (20170801) A61K 2300/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 2300/252 (20130101)
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10835556 — Hydrolyzed tetravalent metal salts and methods of biofilm inhibition

US 10835556	Pesavento
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S)	Russell Pesavento (Chicago, Illinois)
ABSTRACT	Described herein are hydrolyzed tetravalent salts and formulations thereof that can be used to inhibit a biofilm. Also described herein are uses of the hydrolyzed tetravalent salts and formulations thereof to inhibit a biofilm and/or treat biofilm infection.
FILED	Thursday, February 28, 2019
APPL NO	16/288694
ART UNIT	1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 33/00 (20130101) A61K 33/244 (20190101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 29/16 (20130101) A61L 31/16 (20130101) A61L 2300/102 (20130101) A61L 2300/404 (20130101) A61L 2300/606 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 11/00 (20130101)
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10835575 — Compositions and methods for treating disease using Salmonella T3SS effector protein (SipA)

US 10835575	McCormick et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)	University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Beth McCormick (Haverhill, Massachusetts); Regino Mecado-Lubo (Worcester, Massachusetts)
ABSTRACT	The invention provides compositions and methods for reducing one or more symptoms of disease by administering compositions comprising SipA. The invention's compositions and methods are particularly advantageous in reducing symptoms of diseases that are associated with overexpression of P-gp and/or p53. The invention's compositions and methods are useful in reducing cancer symptom and/or cancer multidrug resistance (MDR). The invention provides a method for reducing one or more symptoms of cancer in a mammalian subject in need thereof, comprising administering to said subject a composition comprising purified SipA. In one embodiment, said SipA is operably conjugated to a nanoparticle. In another embodiment, said cancer comprises cancer cells resistant to at least one cytotoxin.
FILED	Thursday, December 20, 2018
APPL NO	16/227802
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/164 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/54 (20170801) A61K 47/64 (20170801) A61K 47/542 (20170801) A61K 47/6811 (20170801) A61K 47/6923 (20170801) Technologies for Adaptation to Climate Change Y02A 50/481 (20180101)
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10835581 — Method of treating insulin resistance

US 10835581	Gladwin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Mark Gladwin (Pittsburgh, Pennsylvania); Courtney E. Sparacino-Watkins (Pittsburgh, Pennsylvania); Michael Jurczak (Pittsburgh, Pennsylvania)
ABSTRACT	A method of treating hyperglycemia, diabetes, metabolic syndrome, insulin resistance (insulin insensitivity), impaired glucose tolerance, high glucose levels, pulmonary hypertension, and/or a condition arising from any of the foregoing in a patient is provided. The method comprises knocking down mARC2 or mARC1 expression in the patient, or otherwise decreasing mARC2 and mARC1 activity in the patient.
FILED	Wednesday, November 28, 2018
APPL NO	16/202667
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 38/28 (20130101) Original (OR) Class A61K 48/0016 (20130101) A61K 48/0066 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101)
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10835593 — Modified anthrax toxin protective antigen

US 10835593	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Shi-Hui Liu (Gaithersburg, Maryland); Stephen H. Leppla (Bethesda, Maryland); Thomas H. Bugge (Bethesda, Maryland); Alexander N. Wein (Decatur, Georgia); Diane E. Peters (Grafton, Massachusetts); Jie Liu (Gaithersburg, Maryland); Kuang-Hua Chen (Gaithersburg, Maryland)
ABSTRACT	Disclosed is a Bacillus anthracis protective antigen (PA) comprising a PA amino acid sequence, wherein one or more of amino acid residues I207, I210, E654, I656, R659, M662, Y681, and L687, as defined by reference to SEQ ID NO: 1, are, independently, substituted, with the proviso that amino acid residue I207 is not substituted with alanine and amino acid residue I210 is not substituted with alanine. Related compositions, nucleic acids, recombinant expression vectors, host cells, populations of cells, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.
FILED	Thursday, August 25, 2016
APPL NO	15/755341
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/07 (20130101) Original (OR) Class A61K 39/0011 (20130101) A61K 45/06 (20130101) A61K 2039/5158 (20130101) A61K 2039/55522 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/325 (20130101)
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10835599 — Methods to identify prime and boost immunogens for use in a B cell lineage-based vaccination protocol

US 10835599	Haynes et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Duke University (Durham, North Carolina); Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	DUKE UNIVERSITY (Durham, North Carolina); CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
INVENTOR(S)	Barton F. Haynes (Durham, North Carolina); Garnett Kelsoe (Durham, North Carolina); Stephen Harrison (Boston, Massachusetts); Thomas B. Kepler (Boston, Massachusetts)
ABSTRACT	The present invention relates, in general, to an HIV-1 vaccine and, in particular, to a B cell lineage-based vaccination protocol.
FILED	Tuesday, October 09, 2018
APPL NO	16/155018
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 2039/70 (20130101) A61K 2039/55511 (20130101) Peptides C07K 16/1063 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16034 (20130101) C12N 2740/16134 (20130101) C12N 2770/00034 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201)
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10835604 — Biomaterials for combined radiotherapy and immunotherapy of cancer

US 10835604	Ngwa et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Northeastern University (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Northeastern University (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S)	Wilfred Ngwa (Orlando, Florida); Rajiv Kumar (Malden, Massachusetts); Gerassimos Makrigiorgos (Chestnut Hill, Massachusetts); Srinivas Sridhar (Newton, Massachusetts); Stephanie Dougan (Boston, Massachusetts)
ABSTRACT	Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be configured as, or be a component of, brachytherapy spacers and applicators, or radiotherapy fiducial markers. The composition may be combined with marginless radiotherapy, allowing for lower doses of radiation and enhancing the immune response against cancer, including at non-irradiated sites.
FILED	Monday, August 15, 2016
APPL NO	15/752099
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 41/0038 (20130101) Original (OR) Class A61K 47/6923 (20170801) A61K 47/6929 (20170801) A61K 49/0428 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 5/1007 (20130101) A61N 7/00 (20130101) A61N 2005/1019 (20130101) A61N 2005/1089 (20130101) A61N 2005/1098 (20130101) Peptides C07K 16/2878 (20130101)
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10835607 — Monoclonal antibody and vaccine targeting filamentous bacteriophage

US 10835607	Bollyky et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	INIMMUNE CORPORATION (Missoula, Montana)
ASSIGNEE(S)	INIMMUNE CORPORATION (Missoula, Montana)
INVENTOR(S)	Paul L. Bollyky (Stanford, California); William Parks (Seattle, Washington); Patrick Secor (Seattle, Washington)
ABSTRACT	Described here is a method for reducing or preventing Pseudomonas aeruginosa biofilm formation in a human subject in need thereof, comprising administering to the human subject a first composition comprising (a) an antigen-binding polypeptide that binds Pf-family bacteriophage, or (b) a vaccine against Pf-family bacteriophage. Also described is an antigen-binding polypeptide that binds specifically to a CoaB protein of Pf-family bacteriophage or fragment thereof.
FILED	Wednesday, January 30, 2019
APPL NO	16/262548
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/104 (20130101) A61K 45/06 (20130101) Original (OR) Class A61K 47/646 (20170801) Peptides C07K 16/08 (20130101) C07K 2317/76 (20130101)
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10835612 — Lipids and compositions for the delivery of therapeutics

US 10835612	Manoharan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Arbutus Biopharma Corporation (Burnaby, Canada)
ASSIGNEE(S)	ARBUTUS BIOPHARMA CORPORATION (Burnaby, Canada)
INVENTOR(S)	Muthiah Manoharan (Cambridge, Massachusetts); Kallanthottathil G. Rajeev (Cambridge, Massachusetts); David Butler (Medford, Massachusetts); Jayaprakash K. Nair (Cambridge, Massachusetts); Muthusamy Jayaraman (Cambridge, Massachusetts); Laxman Eltepu (Cambridge, Massachusetts)
ABSTRACT	The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures:
FILED	Tuesday, August 08, 2017
APPL NO	15/671809
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 31/713 (20130101) A61K 31/7088 (20130101) A61K 39/00 (20130101) A61K 39/39 (20130101) A61K 47/10 (20130101) A61K 47/18 (20130101) A61K 47/20 (20130101) A61K 47/28 (20130101) A61K 47/44 (20130101) Original (OR) Class A61K 2039/55555 (20130101) A61K 2039/55561 (20130101) Acyclic or Carbocyclic Compounds C07C 229/08 (20130101) C07C 229/30 (20130101) C07C 237/16 (20130101) C07C 251/38 (20130101) C07C 251/78 (20130101) C07C 271/12 (20130101) C07C 271/20 (20130101) C07C 323/25 (20130101) Heterocyclic Compounds C07D 203/10 (20130101) C07D 317/28 (20130101) C07D 317/44 (20130101) C07D 317/46 (20130101) C07D 317/72 (20130101) C07D 319/06 (20130101) C07D 405/12 (20130101) C07D 491/056 (20130101) C07D 491/113 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/3515 (20130101) C12N 2320/32 (20130101) Technologies for Adaptation to Climate Change Y02A 50/464 (20180101)
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10835615 — Supramolecular hydrogels containing angiotensin receptor blockers for targeted treatment of diabetic wounds

US 10835615	Cui et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
INVENTOR(S)	Honggang Cui (Lutherville-timonium, Maryland); Jeremy D. Walston (Baltimore, Maryland); Peter M. Abadir (Woodstock, Maryland); Ran Lin (Baltimore, Maryland)
ABSTRACT	The invention described herein provides novel ampiphilic compounds that self-assemble into a hydrogel composition useful for treating wounds, including chronic wounds and diabetic wounds. The compounds of the invention have structural characteristics, such as hydrophilic and hydrophobic moieties, that enable self-assembly into discrete nanostructures, which then entangle to form the hydrogel. Also provided are methods for treating wounds.
FILED	Friday, September 30, 2016
APPL NO	15/765357
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) A61K 31/41 (20130101) A61K 31/4178 (20130101) A61K 31/4184 (20130101) A61K 31/4245 (20130101) A61K 47/55 (20170801) A61K 47/65 (20170801) Original (OR) Class A61K 47/6903 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101)
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10835620 — Methods for treating heart failure using beta-ARKnt peptide

US 10835620	Koch et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Temple University Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania)
ASSIGNEE(S)	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Philadelphia, Pennsylvania)
INVENTOR(S)	Walter J. Koch (Malvern, Pennsylvania); Sarah M. Schumacher-Bass (Landsdale, Pennsylvania)
ABSTRACT	This invention is generally related to novel compositions for treating or preventing heart failure. Specifically, the disclosure provides a composition comprising an amino-terminal domain of Beta.adrenergic receptor kinase-1 (Beta.ARKnt) peptide, or a nucleic acid encoding Beta.ARKnt. Further disclosed are methods of using the compositions for treating or preventing heart failure in a subject or for altering Beta.-adrenergic receptor (Beta.AR) density in a subject.
FILED	Monday, June 05, 2017
APPL NO	16/306718
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/43 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 2750/14143 (20130101) Enzymes C12Y 207/11015 (20130101)
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10835623 — Manganese-based chelate conjugates for molecular MR imaging

US 10835623	Gale et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Eric M. Gale (Charlestown, Massachusetts); Peter Caravan (Cambridge, Massachusetts)
ABSTRACT	Provided herein are examples of metal chelating ligands that have high affinity for manganese. The resultant metal complexes can be used as MRI contrast agents, and can be functionalized with moieties that bind to or cause relaxivity change in the presence of biochemical targets.
FILED	Friday, August 12, 2016
APPL NO	15/751617
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 49/14 (20130101) A61K 49/085 (20130101) Original (OR) Class A61K 49/101 (20130101) A61K 49/103 (20130101) Heterocyclic Compounds C07D 213/40 (20130101) C07D 213/65 (20130101) C07D 213/68 (20130101) C07D 213/80 (20130101) C07D 213/87 (20130101) C07D 217/14 (20130101) C07D 233/58 (20130101) C07D 235/14 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 13/005 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101)
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10835652 — Magnetically-levitated blood pump with optimization method enabling miniaturization

US 10835652	Ricci et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Worldheart Corporation (Miami Lakes, Florida); Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	Worldheart Corporation (Miami Lakes, Florida)
INVENTOR(S)	Michael R. Ricci (Camarillo, California); James F. Antaki (Pittsburgh, Pennsylvania); Josiah E. Verkaik (Lompoc, California); David B. Paden (Goleta, California); Shaun T. Snyder (Santa Barbara, California); Bradley E. Paden (Goleta, California); Jingchun Wu (Irvine, California)
ABSTRACT	A magnetically-levitated blood pump with an optimization method that enables miniaturization and supercritical operation. The blood pump includes an optimized annular blood gap that increases blood flow and also provides a reduction in bearing stiffness among the permanent magnet bearings. Sensors are configured and placed optimally to provide space savings for the motor and magnet sections of the blood pump. Rotor mass is increased by providing permanent magnet placement deep within the rotor enabled by a draw rod configuration.
FILED	Wednesday, March 09, 2016
APPL NO	15/064960
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/10 (20130101) A61M 1/101 (20130101) A61M 1/122 (20140204) A61M 1/127 (20130101) A61M 1/1015 (20140204) Original (OR) Class A61M 1/1031 (20140204) A61M 1/1034 (20140204) A61M 1/1086 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 32/0448 (20130101) F16C 2316/18 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49012 (20150115)
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10835704 — Reusable respiratory protection device

US 10835704	Heimbuch et al.
FUNDED BY	Department of Health and Human Services (HHS) Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA)
APPLICANT(S)	Applied Research Associates, Inc. (Albuquerque, New Mexico)
ASSIGNEE(S)	Applied Research Associates, Inc. (Albuquerque, New Mexico)
INVENTOR(S)	Brian K. Heimbuch (Albuquerque, New Mexico); Delbert A. Harnish (Albuquerque, New Mexico); Geoffrey A. Kibble (Albuquerque, New Mexico); Thomas B. Stephenson (Albuquerque, New Mexico); Sheila J. Nogueira-Prewitt (Albuquerque, New Mexico); Christopher G. Estkowski (Pullman, Michigan); Johnnie H. Copley (Minooka, Illinois); Graham Wilson (Flint, United Kingdom); Chris Ward (St. Asaph, United Kingdom)
ABSTRACT	A reusable respirator including a mask adapted for covering and conforming to the face around the nose and a mouth of a user, a strap configured to secure the mask to a face of the user, and a filter component. All components of the respirator are capable of being cleaned, disinfected and sterilized at temperatures in excess of 50° C. An outer surface of the mask is substantially smooth and wettable for easily disinfecting and is shaped with a pair of outer shield portions for housing particulate air filters. The outer shield portions each include a closeable vent through the outer surface that is adapted to provide a user seal check and direct air flow through the outer surface for filtering by the respective particulate air filter, which is adapted to filter at least 95% of airborne particles.
FILED	Monday, April 20, 2020
APPL NO	16/852993
ART UNIT	3785 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/0035 (20130101) A61L 2/206 (20130101) A61L 2202/22 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0605 (20140204) A61M 16/0683 (20130101) A61M 16/1065 (20140204) Original (OR) Class A61M 2202/203 (20130101) A61M 2202/206 (20130101) A61M 2209/088 (20130101)
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10835710 — Segmented MRI catheters and other interventional devices

US 10835710	Lederman et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
INVENTOR(S)	Robert J. Lederman (Chevy Chase, Maryland); Ozgur Kocaturk (Rockville, Maryland)
ABSTRACT	Disclosed herein are segmented MRI-compatible interventional devices, such as catheters and guidewires, that provide desired mechanical properties while avoiding undesired interactions with MRI fields. Disclosed devices can include helical wires with insulated breaks at intervals along each wire so that the insulated wire segments are individually short enough to avoid substantial resonance and heat being generated in the wires due to an applied MRI field. The segmented wires can be organized into a braided/woven tubular configuration or a non-braided intercalated/parallel tubular configuration that provides the desired mechanical properties similar to conventional metallic braided catheters. The helical wire segments can be insulated such that the wires do not touch each other at points where they cross over each other. Breaks in the wires can be staggered along the longitudinal axis of the device and/or circumferentially around the device to minimize formation of weak areas where wire breaks are aligned or grouped.
FILED	Wednesday, September 14, 2016
APPL NO	15/755186
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 17/00 (20130101) A61B 2017/00292 (20130101) A61B 2017/00911 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/00 (20130101) A61M 25/005 (20130101) Original (OR) Class A61M 25/0012 (20130101) A61M 25/0043 (20130101) A61M 25/0045 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/285 (20130101) G01R 33/287 (20130101)
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10836708 — Process for the synthesis of (s) 3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid

US 10836708	Silverman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois)
INVENTOR(S)	Richard B. Silverman (Winnetka, Illinois); Matthew Moschitto (Gloucester, Massachusetts)
ABSTRACT	Provided herein are processes, compounds and compositions for making (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid. Also provided herein a pharmaceutical compositions containing (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid.
FILED	Tuesday, May 28, 2019
APPL NO	16/423761
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 227/16 (20130101) Original (OR) Class C07C 229/48 (20130101)
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10836720 — Inhibitors of integrin alpha 5 beta 1 and methods of use

US 10836720	Sheppard et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Dean Sheppard (Oakland, California); Aparna Sundaram (San Francisco, California); William F. Degrado (San Francisco, California); Hyunil Jo (Lafayette, California); Joel McIntosh (Pacifica, California)
ABSTRACT	Disclosed herein, inter alia, are inhibitors of integrin alpha 5 beta 1 and methods of using the same.
FILED	Friday, March 31, 2017
APPL NO	16/090022
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) Heterocyclic Compounds C07D 207/16 (20130101) C07D 207/48 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 405/12 (20130101) C07D 453/02 (20130101)
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10836721 — Thalidomide analogs and methods of use

US 10836721	Greig et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); University Court of the University of Aberdeen (Aberdeen, United Kingdom)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); University Court of the University of Aberdeen (Aberdeen, United Kingdom)
INVENTOR(S)	Nigel H. Greig (Phoenix, Maryland); Weiming Luo (Lutherville, Maryland); David Tweedie (Joppa, Maryland); Neil Vargesson (Aberdeen, United Kingdom); Shaunna Beedie (Aberdeen, United Kingdom); William Douglas Figg (Fairfax, Virginia)
ABSTRACT	Thalidomide analogs and methods of using the thalidomide analogs are disclosed. Some embodiments of the disclosed compounds exhibit anti-angiogenic and/or anti-inflammatory activity. Certain embodiments of the disclosed compounds are non-teratogenic.
FILED	Wednesday, June 24, 2020
APPL NO	16/910708
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/428 (20130101) A61K 31/431 (20130101) A61K 31/454 (20130101) A61K 31/536 (20130101) A61K 31/4035 (20130101) A61K 31/4545 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 209/44 (20130101) Original (OR) Class C07D 209/46 (20130101) C07D 209/48 (20130101) C07D 209/52 (20130101) C07D 401/04 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 413/04 (20130101) C07D 417/04 (20130101) C07D 471/04 (20130101) C07D 499/80 (20130101)
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10836722 — Inhibitors of EGFR and methods of use thereof

US 10836722	Gray et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S)	Nathanael S. Gray (Boston, Massachusetts); Michael Eck (Brookline, Massachusetts); Pasi Janne (Needham, Massachusetts); Hwan Geun Choi (Seoul, South Korea); Jaebong Jang (Boston, Massachusetts); Kwok-Kin Wong (Arlington, Massachusetts)
ABSTRACT	The disclosure relates to a compound having Formula (I′): and in particular, Compound I-126: which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
FILED	Thursday, June 13, 2019
APPL NO	16/440803
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 209/46 (20130101) Original (OR) Class C07D 277/46 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) C07D 513/04 (20130101)
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10836733 — HDAC inhibitors and therapeutic methods using the same

US 10836733	Kozikowski et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S)	Alan Kozikowski (Chicago, Illinois); Irina Gaisina (Berwyn, Illinois)
ABSTRACT	Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.
FILED	Wednesday, August 31, 2016
APPL NO	15/756086
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/42 (20130101) A61K 31/422 (20130101) A61K 31/422 (20130101) A61K 31/427 (20130101) A61K 31/427 (20130101) A61K 31/4155 (20130101) A61K 31/4155 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 261/10 (20130101) Original (OR) Class C07D 261/18 (20130101) C07D 413/06 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) Technologies for Adaptation to Climate Change Y02A 50/411 (20180101)
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10836735 — Compositions and methods for treating cancers

US 10836735	Edderkaoui et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S)	CEDARS-SINAI MEDICAL CENTER (Los Angeles, California)
ASSIGNEE(S)	CEDARS-SINAI MEDICAL CENTER (Los Angeles, California)
INVENTOR(S)	Mouad Edderkaoui (Los Angeles, California); Ramachandran Murali (Swarthmore, Pennsylvania); Stephen Pandol (Los Angeles, California)
ABSTRACT	The invention describes compounds that inhibit both HDAC and GSK3β (i.e., HDAC/GSK3β dual inhibitors). The invention further describes compositions containing these HDAC/GSK3β dual inhibitors, as well as methods and kits using these HDAC/GSK3β dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3β to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3β. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.
FILED	Monday, March 04, 2019
APPL NO	16/292011
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/433 (20130101) A61K 31/433 (20130101) A61K 31/4245 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 271/10 (20130101) C07D 271/107 (20130101) C07D 271/113 (20130101) C07D 285/08 (20130101) Original (OR) Class
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10836759 — Thiazole derivatives useful as mutant IDH1 inhibitors for treating cancer

US 10836759	Boxer et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland); THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina)
ASSIGNEE(S)	THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
INVENTOR(S)	Matthew Brian Boxer (New Market, Maryland); Xiaodong Wang (Chapel Hill, North Carolina); Kyle Ryan Brimacombe (Bethesda, Maryland); Mindy Irene Emily Davis (Rockville, Maryland); Yuhong Fang (Rockville, Maryland); Matthew Hall (Rockville, Maryland); Ajit Jadhav (Chantilly, Virginia); Surendra Karavadhi (Gaithersburg, Maryland); Li Liu (Germantown, Maryland); Natalia Martinez (Rockville, Maryland); Andrew Louis McIver (Durham, North Carolina); Rajan Pragani (Gaithersburg, Maryland); Jason Matthew Rohde (Poolesvile, Maryland); Anton Simeonov (Bethesda, Maryland); Wei Zhao (Rockville, Maryland); Min Shen (Boyds, Maryland)
ABSTRACT	A compound of Formula II or a pharmaceutically acceptable salt thereof, wherein CyN is a cyclic amine group bound via a nitrogen atom; X is C or N; R¹and R²are each independently a halogen, CN, CF₃, CHF₂, CH₂F, a C₁-C10alkyl group, a C1-C₁₀alkoxy group, a di(C₁-C₅alkyl)amino; m and n are each independently 1, 2, or 3, and represents either a single bond or a double bond, wherein the racemic mixture of 3-(4-(4-chlorophenyl)thiazol-2-yl)-1-(2-ethyl-5-methoxyphenyl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one atropisomers is excluded.
FILED	Wednesday, June 21, 2017
APPL NO	16/312206
ART UNIT	1699 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/4995 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/07 (20130101) Heterocyclic Compounds C07D 417/04 (20130101) C07D 417/14 (20130101) Original (OR) Class C07D 487/08 (20130101)
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10836761 — Cinchonine-derived catalysts and methods of using same

US 10836761	Wu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	BRANDEIS UNIVERSITY (Waltham, Massachusetts)
ASSIGNEE(S)	Brandeis University (Waltham, Massachusetts)
INVENTOR(S)	Yongwei Wu (Waltham, Massachusetts); Li Deng (Waltham, Massachusetts)
ABSTRACT	The present invention includes certain conchinine-derived phase-transfer catalysts of formula (I), compositions comprising the same, and methods of promoting asymmetric addition reactions using the same.
FILED	Wednesday, December 16, 2015
APPL NO	16/063078
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 453/04 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/1804 (20130101)
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10836805 — Chemoenzymatic glycoengineering of antibodies and FC fragments thereof

US 10836805	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland)
ASSIGNEE(S)	UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland)
INVENTOR(S)	Lai-Xi Wang (Ellicott City, Maryland); Wei Huang (Shanghai, Minhang District, China PRC)
ABSTRACT	The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans.
FILED	Wednesday, June 05, 2019
APPL NO	16/431907
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 47/6849 (20170801) A61K 47/6867 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 35/00 (20180101) Peptides C07K 14/473 (20130101) Original (OR) Class C07K 14/4725 (20130101) C07K 16/00 (20130101) C07K 16/18 (20130101) C07K 16/2809 (20130101) C07K 16/2887 (20130101) C07K 2317/10 (20130101) C07K 2317/14 (20130101) C07K 2317/41 (20130101) C07K 2317/52 (20130101) C07K 2317/72 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/2402 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 1/46 (20130101) Enzymes C12Y 302/01096 (20130101)
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10836808 — Binding-triggered transcriptional switches and methods of use thereof

US 10836808	Lim et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Wendell A. Lim (San Francisco, California); Leonardo Morsut (San Francisco, California); Kole T. Roybal (San Francisco, California); Satoshi Toda (San Francisco, California); Justin Thomas Farlow (San Francisco, California)
ABSTRACT	The present disclosure provides binding-triggered transcriptional switch polypeptides, nucleic acids comprising nucleotide sequences encoding the binding-triggered transcriptional switch polypeptides, and host cells genetically modified with the nucleic acids. The present disclosure also provides chimeric Notch receptor polypeptides, nucleic acids comprising nucleotide sequences encoding the chimeric Notch receptor polypeptides, and host cells transduced and/or genetically modified with the nucleic acids. The present disclosure provides transgenic organisms comprising a nucleic acid encoding a binding triggered transcriptional switch polypeptide and/or a chimeric Notch receptor polypeptide of the present disclosure. Binding triggered transcriptional switch polypeptides and chimeric Notch receptor polypeptides of the present disclosure are useful in a variety of applications, which are also provided.
FILED	Friday, December 01, 2017
APPL NO	15/829370
ART UNIT	1699 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 48/00 (20130101) Peptides C07K 14/71 (20130101) C07K 14/705 (20130101) Original (OR) Class C07K 14/715 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/2803 (20130101) C07K 19/00 (20130101) C07K 2317/22 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) C07K 2319/32 (20130101) C07K 2319/33 (20130101) C07K 2319/60 (20130101) C07K 2319/74 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) G01N 33/566 (20130101) G01N 33/6863 (20130101) G01N 33/6872 (20130101)
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10836810 — Monoclonal antibodies and cocktails for treatment of ebola infections

US 10836810	Bornholdt et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	MAPP BIOPHARMACEUTICAL, INC. (San Diego, California); Albert Einstein College of Medicine (Bronx, New York); Adimab, LLC (Lebanon, New Hampshire)
ASSIGNEE(S)	MAPP BIOPHARMACEUTICAL, INC. (San Diego, California); ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York); ADIMAB, LLC (Lebanon, New Hampshire)
INVENTOR(S)	Zachary A. Bornholdt (Encinitas, California); Larry Zeitlin (San Diego, California); Kartik Chandran (Brooklyn, New York); Anna Wec (Lebanon, New Hampshire); Laura Walker (Norwich, Vermont)
ABSTRACT	Described herein are compositions and methods for the prevention and treatment of ebolavirus infection certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
FILED	Saturday, February 17, 2018
APPL NO	15/898524
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 2039/55 (20130101) A61K 2039/57 (20130101) A61K 2039/62 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) A61K 2039/6075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/76 (20130101)
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10836811 — Broadly neutralizing human immunodeficiency virus type 1 (HIV-1) GP120-specific monoclonal antibody

US 10836811	Chan-Hui et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) U.S. Agency for International Development (USAID)
APPLICANT(S)	Theraclone Sciences, Inc. (Seattle, Washington); The Scripps Research Institute (La Jolla, California); International AIDS Vaccine Initiative (New York, New York)
ASSIGNEE(S)	Theraclone Sciences, Inc. (Seattle, Washington); The Scripps Research Institute (La Jolla, California); International AIDS Vaccine Initiative (New York, New York)
INVENTOR(S)	Po-Ying Chan-Hui (Bellevue, Washington); Katherine Doores (San Diego, California); Michael Huber (Zurich, Switzerland); Stephen Kaminsky (Bronx, New York); Steven Frey (Redmond, Washington); Ole Olsen (Everett, Washington); Jennifer Mitcham (Redmond, Washington); Matthew Moyle (Redmond, Washington); Sanjay K. Phogat (Edison, New Jersey); Dennis R. Burton (La Jolla, California); Laura Majorie Walker (San Diego, California); Pascal Raymond Georges Poignard (San Diego, California); Wayne Koff (Stony Brook, New York); Melissa Danielle De Jean De St. Marcel Simek-Lemos (Brooklyn, New York)
ABSTRACT	The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
FILED	Tuesday, September 12, 2017
APPL NO	15/701679
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/51 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101)
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10836815 — Generation and comparative kinetic analysis of new glycosynthase mutants from Streptococcus pyogenes endoglycosidases for antibody glycoengineering

US 10836815	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	UNIVERSITY OF MARYLAND, COLLEGE PARK (Waldorf, Maryland)
ASSIGNEE(S)	UNIVERSITY OF MARYLAND, COLLEGE PARK (Waldorf, Maryland)
INVENTOR(S)	Lai-Xi Wang (Ellicott City, Maryland); Xin Tong (College Park, Maryland); Tiezheng Li (Columbia, Maryland)
ABSTRACT	The present invention provides for recombinant Endo-S mutants (named Endo-S glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.
FILED	Friday, June 29, 2018
APPL NO	16/023479
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 47/61 (20170801) A61K 47/549 (20170801) A61K 47/6803 (20170801) Peptides C07K 1/02 (20130101) C07K 1/36 (20130101) C07K 1/045 (20130101) C07K 1/1077 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 16/32 (20130101) C07K 16/2887 (20130101) C07K 2317/10 (20130101) C07K 2317/24 (20130101) C07K 2317/41 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 1/46 (20130101) Enzymes C12Y 302/01096 (20130101)
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10836826 — Drug delivery compositions and uses thereof

US 10836826	Goldberg et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S)	Michael Solomon Goldberg (Brookline, Massachusetts); Chun Gwon Park (Seoul, South Korea)
ABSTRACT	Provided are drug delivery compositions and devices useful for the treatment and/or prevention of cancer and metastatic tumors. For example, a drug delivery device is provided that comprises a biodegradable scaffold carrying one or more anti-cancer therapeutic agents that activate the innate immune system (e.g., STING agonists) and/or the adaptive immune system (e.g., anti-PD-1 antibodies). The compositions and devices may include a cytokine (e.g., IL-15 superagonist). The drug delivery device can be implanted in the void volume of a resected tumor to prevent tumor regrowth and tumor metastasis. Also provided are methods of making the drug delivery compositions and devices as well as kits containing materials to provide the compositions and devices.
FILED	Monday, August 26, 2019
APPL NO	16/551436
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 9/0024 (20130101) A61K 31/444 (20130101) A61K 31/444 (20130101) A61K 31/635 (20130101) A61K 31/635 (20130101) A61K 31/4745 (20130101) A61K 31/4745 (20130101) A61K 35/17 (20130101) A61K 38/19 (20130101) A61K 38/19 (20130101) A61K 38/1793 (20130101) A61K 38/2086 (20130101) A61K 39/3955 (20130101) A61K 39/39541 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 47/36 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Peptides C07K 16/30 (20130101) C07K 16/2818 (20130101) Original (OR) Class C07K 16/2878 (20130101) C07K 16/2896 (20130101) C07K 2317/75 (20130101)
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10837001 — Cardiomyocyte maturation platform

US 10837001	Fong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of The University of California (Oakland, California)
INVENTOR(S)	Ashley H. Fong (Irvine, California); Christopher C. W. Hughes (Irvine, California)
ABSTRACT	Disclosed herein are methods of inducing and/or promoting cardiomyocyte maturation comprising: providing an immature cardiomyocyte; providing a three dimensional (3D) cardiac extracellular matrix (ECM) scaffold; and inducing and/or promoting cardiomyocyte cell maturation by seeding the immature cardiomyocyte in the 3D cardiac ECM scaffold and harvesting once the cardiomyocyte has reached maturity. Also disclosed herein are methods of treating a disease in a mammal comprising transplanting a mature cardiomyocyte into an ischemic heart, wherein the mature cardiomyocyte is generated comprising the steps of: providing an immature cardiomyocyte; providing a 3D cardiac ECM scaffold; and generating mature cardiomyocyte by seeding the immature cardiomyocyte in a 3D cardiac ECM scaffold or co-culturing the immature cardiomyocyte in the presence of endothelial cells or stromal cells; and harvesting once the cardiomyocyte has reached maturity.
FILED	Thursday, March 02, 2017
APPL NO	15/448505
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) A61K 35/34 (20130101) A61K 35/44 (20130101) A61K 35/44 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/0657 (20130101) Original (OR) Class C12N 2501/727 (20130101) C12N 2502/28 (20130101) C12N 2502/45 (20130101) C12N 2503/02 (20130101) C12N 2503/04 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101)
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10837003 — Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3′-utr of dengue types 1, 2, 3, and 4, or antigenic chimeric dengue viruses 1, 2, 3, and 4

US 10837003	Whitehead et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Stephen S. Whitehead (Montgomery Village, Maryland); Brian R. Murphy (Bethesda, Maryland); Lewis Markoff (Bethesda, Maryland); Barry Falgout (Rockville, Maryland); Joseph Blaney (Gettysburg, Pennsylvania); Kathryn Hanley (Las Cruces, New Mexico); Ching-Juh Lai (Bethesda, Maryland)
ABSTRACT	The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (Δ30) in the 3′-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.
FILED	Wednesday, September 20, 2017
APPL NO	15/710672
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/70 (20130101) A61K 2039/5254 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2770/24134 (20130101) C12N 2770/24161 (20130101) Technologies for Adaptation to Climate Change Y02A 50/386 (20180101)
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10837015 — Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer

US 10837015	Kimmelman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
INVENTOR(S)	Alec C. Kimmelman (Weston, Massachusetts); Jaekyoung Son (Somerville, Massachusetts); Lewis Cantley (Cambridge, Massachusetts); Costas A. Lyssiotis (Jamaica Plain, Massachusetts)
ABSTRACT	Methods and kits for GPP-targeting, e.g., for the treatment of oncogenic Kras-associated cancers, and methods for determining the efficacy of those methods are provided.
FILED	Friday, October 12, 2018
APPL NO	16/158634
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/04 (20130101) A61K 31/194 (20130101) A61K 31/4196 (20130101) A61K 31/7068 (20130101) Peptides C07K 16/00 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 15/1135 (20130101) C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/16 (20130101) C12N 2310/531 (20130101) C12N 2310/531 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) C12Q 1/52 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/902 (20130101) G01N 2333/914 (20130101) G01N 2333/91188 (20130101) G01N 2800/52 (20130101)
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10837019 — Chimeric antigen receptors targeting B-cell maturation antigen

US 10837019	Kochenderfer
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	James N. Kochenderfer (Bethesda, Maryland)
ABSTRACT	The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
FILED	Friday, November 15, 2019
APPL NO	16/684978
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2878 (20130101) C07K 2317/73 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class
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10837059 — Multiplex nucleic acid reactions

US 10837059	Oliphant et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) U.S. Public Health Service (USPHS)
APPLICANT(S)	Illumina, Inc. (San Diego, California)
ASSIGNEE(S)	Illumina, Inc. (San Diego, California)
INVENTOR(S)	Arnold Oliphant (Sunnyvale, California); John R. Stuelpnagel (Santa Barbara, California); Mark S. Chee (Encinitas, California); Scott L. Butler (Sandwich, United Kingdom); Jian-Bing Fan (San Diego, California); Min-Jui Richard Shen (Poway, California)
ABSTRACT	A method for detecting nucleic acids by (a) providing a sample having target nucleic acids, each nucleic acid having contiguous first, second, and third domains; (b) contacting the sample with probe sets to form hybridization complexes, wherein each probe set includes (i) a first probe having a sequence that is complementary to the first domain; and (ii) a second probe having a sequence substantially complementary to the third domain; (c) extending the first probes along the second domains of the complexes while the complexes are immobilized on a solid support; (d) ligating the extended first probes to the second probes to form templates; (e) amplifying the templates with primers that are complementary to the first and second priming sequences to produce amplicons; and (f) detecting the amplicons on the surface of a nucleic acid array.
FILED	Thursday, November 30, 2017
APPL NO	15/827141
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6834 (20130101) C12Q 1/6834 (20130101) C12Q 1/6837 (20130101) C12Q 1/6876 (20130101) Original (OR) Class C12Q 2525/155 (20130101) C12Q 2563/131 (20130101) C12Q 2563/179 (20130101) C12Q 2600/16 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/143333 (20150115)
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10837060 — Recombination sequence (RS) rearrangement frequency as a measure of central B cell tolerance

US 10837060	Panigrahi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Anil K. Panigrahi (Philadelphia, Pennsylvania); Eline Luning Prak (Malvern, Pennsylvania)
ABSTRACT	The invention relates to methods and materials for diagnosing an autoimmune disease such as SLE, Type 1 diabetes, and the like. More particularly, the invention relates to methods and materials for assessing the frequency of recombination sequence (RS) rearrangement as a novel marker for an autoimmune disease. Such an assay can allow clinicians to diagnose an autoimmune disease based on the RS rearrangement frequency in an autoimmune patient as compared to an otherwise healthy control. In addition, the method includes identifying individuals who are at increased risk of developing autoimmunity. The method may also be helpful in directing the type of therapy and monitoring the effects of therapy in patients with autoimmune or non-autoimmune conditions.
FILED	Monday, August 10, 2015
APPL NO	14/822080
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101)
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10837064 — Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma

US 10837064	Vogelstein et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland); Duke University (Durham, North Carolina)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland); Duke University (Durham, North Carolina)
INVENTOR(S)	Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); D. Williams Parsons (Bellaire, Texas); Xiaosong Zhang (San Francisco, California); Jimmy Cheng-Ho Lin (Baltimore, Maryland); Rebecca J. Leary (Cambridge, Massachusetts); Philipp Angenendt (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Victor Velculescu (Dayton, Maryland); Giovanni Parmigiani (Baltimore, Maryland); Rachel Karchin (Towson, Maryland); Sian Jones (Baltimore, Maryland); Hai Yan (Durham, Maryland); Darell Bigner (Mebane, North Carolina); Chien-Tsun Kuan (Cary, North Carolina); Gregory J. Riggins (White Hall, Maryland)
ABSTRACT	We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.
FILED	Thursday, March 22, 2018
APPL NO	15/928811
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101)
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10837961 — Molecular imprinted colored silica beads

US 10837961	Boland
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Minority Health and Health Disparities (NIMHD)
APPLICANT(S)	Board of Regents, The University Of Texas System (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Thomas Boland (El Paso, Texas)
ABSTRACT	Macromolecular imprinted silica particles (“MIP”) in the presence of polymer grafted carbon black are disclosed. The disclosed molecular imprinted beads can detect disease in body fluids. For the silica gel matrix, tetraethyl orthosilicate (TEOS) was used as the backbone monomer and 3-aminopropy/triethoxysilane (APS) as a functional monomer. Carbon black was added to the sol-gel process, yielding black silica particles. Furthermore, sodium dodecyl sulfate (SDS) was used as a structure-directing agent to increase network diffusion of the template. A total of 16 MIPs were synthetized in parallel with variables that evaluate the role of key reactants in the synthesis procedure. Agglomeration tests were performed with all 16 MIPs in the presence of their template, alongside their respective controls using only phosphate buffered saline (“PBS”). Each of the MIPs was evaluated using a novel device capable of simultaneously measuring up to four samples for near infrared transmission.
FILED	Wednesday, August 06, 2014
APPL NO	14/452765
ART UNIT	1763 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Compositions of Macromolecular Compounds C08L 83/02 (20130101) C08L 83/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/545 (20130101) G01N 33/552 (20130101) Original (OR) Class G01N 33/585 (20130101) G01N 33/54313 (20130101) G01N 2333/59 (20130101) G01N 2600/00 (20130101)
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10837968 — Photoactivatable voltage sensitive dyes

US 10837968	Miller et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Evan Miller (Berkeley, California); Vincent Grenier (Berkeley, California)
ABSTRACT	Compounds and methods for determining transmembrane potential, monitoring changes in transmembrane potential, and/or drug screening are provided. In one aspect, compounds of the invention have a structure according to the formula: E-M-A-C, wherein A is a fluorophore, selected from xanthenes, coumarins, cyanines, bimanes, and difuloroboradizaindacenes, charged at physiological pH; M is a molecular wire; and E is a hydrophobic moiety, wherein A and E are capable of being involved in a photo-induced, intramolecular electron transfer that quenches the fluorescence of A in response to a voltage condition. C is a caging moiety (e.g., a photoremovable protecting group). When in use, exemplary compounds of the invention are membrane-impermeant and oriented within the cell membrane such that the charged moiety localizes at the outer leaflet of the lipid bilayer and the hydrophobic moiety and molecular wire associate with the hydrophobic portion of the lipid bilayer. The rate of electron transfer, fluorescence intensity, and quenching are altered in response to changes in transmembrane potential.
FILED	Thursday, October 01, 2015
APPL NO	15/514786
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Heterocyclic Compounds C07D 311/82 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 11/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/542 (20130101) G01N 33/582 (20130101) Original (OR) Class Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/55 (20151101)
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10837969 — Therapeutic and diagnostic methods for autism spectrum disorders and other conditions

US 10837969	Nath et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Avindra Nath (Ellicott City, Maryland); Tongguang Wang (Lutherville, Maryland); Christina Michelle Morris-Berry (Baltimore, Maryland); Harvey Singer (Baltimore, Maryland)
ABSTRACT	The present invention relates to the field of autism. More specifically, the present invention provides methods for treating individuals with autism spectrum disorders. The present invention also provides methods for predicting a likelihood of ASD. In one embodiment, a method for treating a female patient having a high risk factor of having children with ASD comprises the steps of (a) identifying in a sample taken from the female patient the presence of AT-1 antibodies; and (b) administering an effective amount of an AT-1 inhibitor or inhibitor of AT-1 antibodies to the female patient.
FILED	Thursday, September 27, 2018
APPL NO	16/144285
ART UNIT	1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4184 (20130101) A61K 31/4525 (20130101) A61K 31/7105 (20130101) A61K 39/3955 (20130101) Peptides C07K 16/2869 (20130101) C07K 2317/10 (20130101) C07K 2317/21 (20130101) C07K 2317/73 (20130101) C07K 2317/75 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 2333/705 (20130101) G01N 2333/726 (20130101) G01N 2800/30 (20130101) G01N 2800/50 (20130101)
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10838116 — Low-power large aperture adaptive lenses for smart eyeglasses

US 10838116	Mastrangelo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S)	Carlos Mastrangelo (Salt Lake City, Utah); Nazmul Hasan (Salt Lake City, Utah); Kim Hanseup (Salt Lake City, Utah)
ABSTRACT	A variable focus optical device (100) can include first optically transparent membrane (102) and a second membrane (104) that at least partially define a chamber (106) retaining an optically transparent liquid. A transparent piston (110) is attached to the second membrane (104). At least one actuator (112a-c) is operatively coupled to the transparent piston (110) and configured to move to change a focal length of the variable focus optical device (100) via actuation of the transparent piston (110). Three curved bimorph actuators (112a-c) can surround and be coupled to the piston (110) for actuation of the piston (110) to generate a plano-convex or plano-concave lens via the membranes (102, 104). A smart eyeglasses system includes a pair of variable focus optical devices (100), an object distance sensor, a battery, optional eye-tracking camera(s), and a microcontroller, collectively used for purposes of sensing distance of objects and adjusting said focal length via the variable focus optical devices (100).
FILED	Friday, January 06, 2017
APPL NO	16/068328
ART UNIT	2872 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 3/14 (20130101) Original (OR) Class G02B 27/0172 (20130101) G02B 27/0176 (20130101) G02B 2027/0138 (20130101) G02B 2027/0178 (20130101) Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/085 (20130101) Electric Digital Data Processing G06F 3/016 (20130101)
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10838193 — Optical article and illumination system for endoscope

US 10838193	Hua et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on Behalf of The University of Arizona (Tucson, Arizona)
INVENTOR(S)	Hong Hua (Tucson, Arizona); Rengmao Wu (Tucson, Arizona); Yi Qin (Tucson, Arizona)
ABSTRACT	An optical element, wherein axially symmetric or not, an output surface of which contains a plurality of indentations configured to increase a degree of divergence of light that is incident onto such surface through an input surface of the optical element. In one implementation, each of the indentations defines a corresponding aspheric lenslet the plurality of which encircles the central opening in the optical element. The optical element can be configured as a lightguide having the specified output surface. An illumination system for a laparoscope employing such optical element as an addition to the optical fiber bundle of the laparoscope or as a fiber bundle itself that has the specified output surface.
FILED	Monday, October 07, 2019
APPL NO	16/595208
ART UNIT	2874 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/07 (20130101) A61B 1/00096 (20130101) A61B 1/00165 (20130101) A61B 1/0607 (20130101) A61B 1/3132 (20130101) Optical Elements, Systems, or Apparatus G02B 3/02 (20130101) G02B 6/0008 (20130101) G02B 23/2469 (20130101) Original (OR) Class
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10839513 — Distinguishing hyperprogression from other response patterns to PD1/PD-L1 inhibitors in non-small cell lung cancer with pre-therapy radiomic features

US 10839513	Vaidya et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Center for Research Resources (NCRR)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Pranjal Vaidya (Cleveland, Ohio); Kaustav Bera (Cleveland, Ohio); Vamsidhar Velcheti (Pepper Pike, Ohio); Anant Madabhushi (Shaker Heights, Ohio)
ABSTRACT	Embodiments access a pre-immunotherapy image of tissue demonstrating NSCLC including a tumor and a peritumoral region; extract a first set of radiomic features from the image; provide the first set of radiomic features to a first machine learning classifier; receive a first probability from the first classifier that the tissue is hyperprogressor (HP) or non-responder (R); if the first probability that the tissue is within a threshold: generate a first classification of the ROT as HP or non-R based on the first probability; if the first probability is not within the threshold: extract a second set of radiomic features from the peritumoral region and provide the second set to a second machine learning classifier; receive a second probability from the second classifier that the tissue is HP or R; generate a second classification of the tissue as HP or R based on the second probability; and display the classification.
FILED	Monday, March 11, 2019
APPL NO	16/297889
ART UNIT	2664 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) G06K 9/6262 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) G06N 20/20 (20190101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/136 (20170101) G06T 2207/10081 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20152 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101)
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10839515 — Systems and methods for generating and displaying OCT angiography data using variable interscan time analysis

US 10839515	Moult et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Eric M. Moult (Cambridge, Massachusetts); James G. Fujimoto (Medford, Massachusetts); Stefan B. Ploner (Langensendelbach, Germany); Woo J. Choi (Seoul, South Korea)
ABSTRACT	An imaging (e.g., with an optical coherence tomography system) method that includes 1) acquiring repeated B-scans in a manner consistent with forming images, 2) processing the acquired images according to a variable interscan time analysis (VISTA) method, and 3) generating and displaying a color-mapped image pixel color of the color-mapped image fluid flow speed, or a related quantity.
FILED	Friday, April 27, 2018
APPL NO	15/964917
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/0041 (20130101) A61B 3/102 (20130101) Image Data Processing or Generation, in General G06T 5/50 (20130101) G06T 7/0016 (20130101) Original (OR) Class G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) G06T 2207/10101 (20130101)
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10839520 — Eye tracking applications in computer aided diagnosis and image processing in radiology

US 10839520	Wood et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	National Institutes of Health (Rockville, Maryland)
ASSIGNEE(S)	The United States of America, as Represented by the Secretary, Department of Health and Human Services (Rockville, Maryland)
INVENTOR(S)	Bradford J. Wood (Bethesda, Maryland); Haydar Celik (Bethesda, Maryland); Ulas Bagci (Oviedo, Florida); Ismail Baris Turkbey (Rockville, Maryland)
ABSTRACT	A system and method for using gaze information to extract visual attention information combined with computer derived local saliency information from medical images to (1) infer object and background cues from a region of interest indicated by the eye-tracking and (2) perform a medical image segmentation process. Moreover, an embodiment is configured to notify a medical professional of overlooked regions on medical images and/or train the medical professional to review regions that he/she often overlooks.
FILED	Monday, March 05, 2018
APPL NO	15/912126
ART UNIT	2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/463 (20130101) A61B 6/582 (20130101) A61B 6/5264 (20130101) Electric Digital Data Processing G06F 3/013 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00597 (20130101) G06K 9/4628 (20130101) G06K 2209/05 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 7/194 (20170101) Original (OR) Class G06T 2207/10081 (20130101) G06T 2207/20101 (20130101) G06T 2207/20164 (20130101) G06T 2207/30064 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/20 (20180101)
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10839940 — Method, computer-accessible medium and systems for score-driven whole-genome shotgun sequence assemble

US 10839940	Mishra et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	Bhubaneswar Mishra (Great Neck, New York); Giuseppe Narzisi (New York, New York)
ASSIGNEE(S)	NEW YORK UNIVERSITY (New York, New York)
INVENTOR(S)	Bhubaneswar Mishra (Great Neck, New York); Giuseppe Narzisi (New York, New York)
ABSTRACT	Exemplary embodiments of the present disclosure relate generally to methods, computer-accessible medium and systems for assembling haplotype and/or genotype sequences of at least one genome, which can be based upon, e.g., consistent layouts of short sequence reads and long-range genome related data. For example, a processing arrangement can be configured to perform a procedure including, e.g., obtaining randomly located short sequence reads, using at least one score function in combination with constraints based on, e.g., the long range data, generating a layout of randomly located short sequence reads such that the layout is globally optimal with respect to the score function, obtained through searching coupled with score and constraint dependent pruning to determine the globally optimal layout substantially satisfying the constraints, generating a whole and/or a part of a genome wide haplotype sequence and/or genotype sequence, and converting a globally optimal layout into one or more consensus sequences.
FILED	Wednesday, December 23, 2009
APPL NO	13/139809
ART UNIT	1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/20 (20190201) Original (OR) Class
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Department of Defense (DOD)

10834896 — Method for tagging insects and arthropods

US 10834896	Lin et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Horn-Bond Lin (Las Vegas, Nevada); Matthew B. Hart (Silver Spring, Maryland); Jay D. Eversole (Woodbridge, Virginia); Keith W. Blount (Brooks City-Base, Texas); Wesley Walker (Brooks City-Base, Texas)
ABSTRACT	Disclosed is an apparatus and associated method for tagging insects and arthropods. According to an exemplary embodiment of this disclosure, an electrosprayer is provided including a nozzle cartridge, a spray chamber removably attached to the nozzle cartridge and a power supply operatively connected to the nozzle cartridge and a grounding plate within the spray chamber to electrically charge droplets expelled from the nozzle which coat one or more insects contained in the spray chamber.
FILED	Tuesday, October 31, 2017
APPL NO	15/798488
ART UNIT	3752 — Fluid Handling and Dispensing
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 11/005 (20130101) Original (OR) Class A01K 67/033 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/0255 (20130101) B05B 5/0533 (20130101) B05B 5/1691 (20130101)
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10835111 — Three-dimensional imaging using swept, confocally aligned planar excitation with an image relay

US 10835111	Hillman
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Elizabeth Marjorie Clare Hillman (New York, New York)
ABSTRACT	The disclosed subject matter includes devices and systems for extending the imaging capability of swept, confocally aligned planar excitation (SCAPE) microscopes to in vivo applications. In embodiments, the SCAPE microscope can be implemented as an endoscopic or laparoscopic inspection instrument.
FILED	Monday, July 10, 2017
APPL NO	16/314752
ART UNIT	2482 — Recording and Compression
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/07 (20130101) A61B 1/00172 (20130101) A61B 1/00174 (20130101) Original (OR) Class A61B 1/00197 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0087 (20130101) G02B 21/006 (20130101) G02B 21/0028 (20130101) G02B 21/0048 (20130101) G02B 21/0076 (20130101) Pictorial Communication, e.g Television H04N 5/2251 (20130101) H04N 2005/2255 (20130101)
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10835146 — Autonomous brain-machine interface

US 10835146	Francis et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON)
APPLICANT(S)	The Research Foundation for the State University of New York (Albany, New York)
ASSIGNEE(S)	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York)
INVENTOR(S)	Joseph T. Francis (Albany, New York); Venkata S. Aditya Tarigoppula (Albany, New York); Brandi T. Marsh (Albany, New York)
ABSTRACT	A reinforcement learning brain-machine interface (RL-BMI) can have a policy that governs how detected signals, emanating from a motor cortex of a subject's brain, are translated into action. The policy can be improved by detecting a motor signal having a characteristic and emanating from the motor cortex. The system can provide, to a device and based on (i) the motor signal and (ii) an instruction policy, a command signal resulting in a first action by a device. Additionally, an evaluation signal, emanating from the motor cortex in response to the first action, can also be detected. With the foregoing information, the system can adjust the policy based on the evaluation signal such that a subsequent motor signal, from the subject's brain, having the characteristic results in a second action, by the device, different from the first action, as needed.
FILED	Friday, December 11, 2015
APPL NO	15/534956
ART UNIT	3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0476 (20130101) A61B 5/0482 (20130101) Original (OR) Class A61B 5/04001 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/68 (20130101) A61F 2002/704 (20130101) A61F 2002/6827 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) G06N 3/061 (20130101) G06N 3/0454 (20130101)
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10835147 — Method for predicting efficacy of a stimulus by measuring physiological response to stimuli

US 10835147	Parra et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA)
APPLICANT(S)	NEUROMATTERS, LLC (New York, New York)
ASSIGNEE(S)	NEUROMATTERS, LLC (New York, New York)
INVENTOR(S)	Lucas Parra (New York, New York); Paul Sajda (New York, New York); Paul DeGuzman (Valley Cottage, New York); Daniel Rosenthal (New York, New York); Charles Phillip Cloud (New York, New York); Jacek Dmochowski (Montclair, New Jersey)
ABSTRACT	Methods are disclosed for determining an efficacy of a stimulus based on one or more measurable physiological responses to one or more stimuli including one or more stimulus features. Data is acquired on physiological responses of a group of one or more subjects to presentation of one or more stimuli including one or more stimulus features. The data on the one or more physiological responses of the one or more subjects is correlated with the presentation of the one or more stimulus features included in the one or more stimuli. The correlated data on the one or more physiological responses are associated with a separately-determined efficacy of the one or more stimuli to form a stimulus efficacy model. From this information, a projected efficacy of a stimulus is determinable by comparing one or more subsequently-measured physiological responses to the stimulus with the stimulus efficacy model.
FILED	Wednesday, August 26, 2015
APPL NO	14/836316
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/11 (20130101) A61B 3/113 (20130101) A61B 5/0205 (20130101) A61B 5/0402 (20130101) A61B 5/04842 (20130101) Original (OR) Class A61B 5/04845 (20130101) A61B 5/7225 (20130101) A61B 5/7275 (20130101) A61B 2503/12 (20130101)
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10835176 — Personalized closed-loop pulsed transcranial stimulation system for cognitive enhancement

US 10835176	Mohammadrezazadeh et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) Department of the Navy (DON)
APPLICANT(S)	HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)	HRL Laboratories, LLC (Malibu, California)
INVENTOR(S)	Iman Mohammadrezazadeh (Los Angeles, California); Praveen K. Pilly (West Hills, California); Michael D. Howard (Westlake Village, California)
ABSTRACT	A system for closed-loop pulsed transcranial stimulation for cognitive enhancement. During operation, the system identifies a region of interest (ROI) in a subject's brain and then estimates ROI source activations based on the estimated source of the ROI. It is then determined if a subject is in a bad encoding state based on the ROI source activations. Finally, one or more electrodes are activated to apply a pulsed transcranial stimulation (tPS) therapy when the subject is in a bad encoding state, a predefined external event or behavior occurs, or the subject is in a consolidation state during sleep.
FILED	Friday, May 18, 2018
APPL NO	15/983336
ART UNIT	3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Hats; Head Coverings A42B 1/04 (20130101) Diagnosis; Surgery; Identification A61B 5/0476 (20130101) A61B 5/0478 (20130101) A61B 5/4836 (20130101) Original (OR) Class A61B 5/6803 (20130101) A61B 5/7485 (20130101) A61B 2562/046 (20130101) A61B 2562/0209 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/0456 (20130101) A61N 1/0476 (20130101) A61N 1/0484 (20130101) A61N 1/36025 (20130101) A61N 1/36031 (20170801)
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10835202 — System and method for analyzing tissue using shear waves

US 10835202	Haupt
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Life Cycle Management Center (AFLCMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Robert W. Haupt (Lexington, Massachusetts)
ABSTRACT	A system and method for determining tissue changes. Shear waves are transmitted across the tissue in response to an ultrasonic signal input exterior to the tissue surface. Adaptive beam forming signal processing is applied to signal returns and arrivals to remove distortions by targeting velocity contrasts. Shear-wave dispersion, such as due to viscosity and mass changes in the tissue, are then estimated and compared to reference data to determine tissue health.
FILED	Tuesday, November 11, 2014
APPL NO	14/538040
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0051 (20130101) A61B 5/055 (20130101) A61B 5/0059 (20130101) A61B 8/08 (20130101) A61B 8/085 (20130101) A61B 8/485 (20130101) A61B 8/488 (20130101) A61B 8/0808 (20130101) Original (OR) Class A61B 8/0858 (20130101) A61B 8/0875 (20130101) A61B 8/5215 (20130101) A61B 8/5223 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/11 (20130101) G01N 29/346 (20130101) G01N 29/0654 (20130101) G01N 2291/0422 (20130101) G01N 2291/02475 (20130101) G01N 2291/02491 (20130101) G01N 2291/02827 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/52042 (20130101) G01S 7/52047 (20130101) G01S 15/8913 (20130101) G01S 15/8915 (20130101)
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10835513 — Methods and treatments for the learning and memory deficits associated with Noonan syndrome

US 10835513	Silva et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Development Command (USAMRDC) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Alcino Silva (Sherman Oaks, California); Yong-Seok Lee (Los Angeles, California); Dan Ehninger (Bonn, Germany)
ABSTRACT	Disclosed herein are methods and compositions for treating learning and memory deficits associated with Noonan Syndrome.
FILED	Friday, June 27, 2014
APPL NO	14/900907
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/22 (20130101) A61K 31/22 (20130101) A61K 31/40 (20130101) A61K 31/40 (20130101) A61K 31/277 (20130101) A61K 31/277 (20130101) A61K 31/366 (20130101) Original (OR) Class A61K 31/366 (20130101) A61K 31/404 (20130101) A61K 31/404 (20130101) A61K 31/505 (20130101) A61K 31/505 (20130101) A61K 31/4418 (20130101) A61K 31/4418 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101)
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10835639 — Biopolymer compositions, scaffolds and devices

US 10835639	Francis et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	EMBODY INC. (Norfolk, Virginia)
ASSIGNEE(S)	EMBODY INC. (Norfolk, Virginia)
INVENTOR(S)	Michael Francis (Norfolk, Virginia); Nathan Kemper (Norfolk, Virginia); Hilary Wriggers (Norfolk, Virginia)
ABSTRACT	Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries.
FILED	Friday, March 13, 2020
APPL NO	16/818241
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 38/39 (20130101) A61K 47/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/24 (20130101) A61L 27/26 (20130101) A61L 27/26 (20130101) A61L 27/26 (20130101) A61L 27/44 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/386 (20130101) A61L 27/3804 (20130101) A61L 2300/64 (20130101) A61L 2300/604 (20130101) A61L 2400/12 (20130101) A61L 2430/10 (20130101) A61L 2430/34 (20130101) Compositions of Macromolecular Compounds C08L 67/04 (20130101) C08L 89/06 (20130101)
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10835657 — Flow balancing devices, methods, and systems

US 10835657	Burbank et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	NxStage Medical, Inc. (Lawrence, Massachusetts)
ASSIGNEE(S)	NxStage Medical, Inc. (Lawrence, Massachusetts)
INVENTOR(S)	Jeffrey H. Burbank (Boxford, Massachusetts); Dennis M. Treu (Castle Rock, Colorado); Daniel J. Rubery, Jr. (Windham, New Hampshire); Scott W. Newell (Ipswich, Massachusetts); James M. Brugger (Newburyport, Massachusetts); William J. Schnell (Libertyville, Illinois); William K. Weigel (Portland, Maine); Steven A. White (Hudson, Massachusetts); Mark T. Wyeth (Andover, Massachusetts); Jerome James (Vestavia, Alabama); David Desouza (Essex, Massachusetts); Joseph E. Turk, Jr. (North Andover, Massachusetts); Garrett Casey (Methuen, Massachusetts)
ABSTRACT	The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.
FILED	Thursday, April 11, 2019
APPL NO	16/381354
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/34 (20130101) A61M 1/165 (20140204) A61M 1/341 (20140204) A61M 1/1605 (20140204) Original (OR) Class A61M 1/1613 (20140204) A61M 1/1615 (20140204) A61M 1/1647 (20140204) A61M 1/3403 (20140204) A61M 1/3434 (20140204) A61M 1/3437 (20140204) A61M 1/3441 (20130101) A61M 1/3444 (20140204) A61M 1/3448 (20140204) A61M 1/3607 (20140204) A61M 1/3609 (20140204) A61M 1/3635 (20140204) A61M 2205/15 (20130101) A61M 2205/058 (20130101) A61M 2205/502 (20130101) A61M 2205/702 (20130101) A61M 2205/3331 (20130101) A61M 2205/3334 (20130101) A61M 2205/3341 (20130101) A61M 2205/3351 (20130101) A61M 2205/3355 (20130101) A61M 2205/3365 (20130101) A61M 2205/3368 (20130101)
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10835658 — Flow balancing devices, methods, and systems

US 10835658	Burbank et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	NxStage Medical, Inc. (Lawrence, Massachusetts)
ASSIGNEE(S)	NxStage Medical, Inc. (Lawrence, Massachusetts)
INVENTOR(S)	Jeffrey H. Burbank (Boxford, Massachusetts); Dennis M. Treu (Castle Rock, Colorado); Daniel J. Rubery, Jr. (Windham, New Hampshire); Scott W. Newell (Ipswich, Massachusetts); James M. Brugger (Newburyport, Massachusetts); William J. Schnell (Libertyville, Illinois); William K. Weigel (Portland, Maine); Steven A. White (Hudson, Massachusetts); Mark T. Wyeth (Andover, Massachusetts); Jerome James (Vestavia, Alabama); David Desouza (Essex, Massachusetts); Joseph E. Turk, Jr. (North Andover, Massachusetts); Garrett Casey (Methuen, Massachusetts)
ABSTRACT	The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.
FILED	Thursday, April 11, 2019
APPL NO	16/381358
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/34 (20130101) A61M 1/165 (20140204) A61M 1/341 (20140204) A61M 1/1605 (20140204) Original (OR) Class A61M 1/1613 (20140204) A61M 1/1615 (20140204) A61M 1/1647 (20140204) A61M 1/3403 (20140204) A61M 1/3434 (20140204) A61M 1/3437 (20140204) A61M 1/3441 (20130101) A61M 1/3444 (20140204) A61M 1/3448 (20140204) A61M 1/3607 (20140204) A61M 1/3609 (20140204) A61M 1/3635 (20140204) A61M 2205/15 (20130101) A61M 2205/058 (20130101) A61M 2205/502 (20130101) A61M 2205/702 (20130101) A61M 2205/3331 (20130101) A61M 2205/3334 (20130101) A61M 2205/3341 (20130101) A61M 2205/3351 (20130101) A61M 2205/3355 (20130101) A61M 2205/3365 (20130101) A61M 2205/3368 (20130101)
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10835659 — Flow balancing devices, methods, and systems

US 10835659	Burbank et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	NxStage Medical, Inc. (Lawrence, Massachusetts)
ASSIGNEE(S)	NxStage Medical, Inc. (Lawrence, Massachusetts)
INVENTOR(S)	Jeffrey H. Burbank (Boxford, Massachusetts); Dennis M. Treu (Castle Rock, Colorado); Daniel J. Rubery, Jr. (Windham, New Hampshire); Scott W. Newell (Ipswich, Massachusetts); James M. Brugger (Newburyport, Massachusetts); William J. Schnell (Libertyville, Illinois); William K. Weigel (Portland, Maine); Steven A. White (Hudson, Massachusetts); Mark T. Wyeth (Andover, Massachusetts); Jerome James (Vestavia, Alabama); David Desouza (Essex, Massachusetts); Joseph E. Turk, Jr. (North Andover, Massachusetts); Garrett Casey (Methuen, Massachusetts)
ABSTRACT	The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.
FILED	Thursday, April 11, 2019
APPL NO	16/381369
ART UNIT	1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) A61M 1/34 (20130101) A61M 1/165 (20140204) A61M 1/341 (20140204) A61M 1/1605 (20140204) Original (OR) Class A61M 1/1613 (20140204) A61M 1/1615 (20140204) A61M 1/1647 (20140204) A61M 1/3403 (20140204) A61M 1/3434 (20140204) A61M 1/3437 (20140204) A61M 1/3441 (20130101) A61M 1/3444 (20140204) A61M 1/3448 (20140204) A61M 1/3607 (20140204) A61M 1/3609 (20140204) A61M 1/3635 (20140204) A61M 2205/15 (20130101) A61M 2205/058 (20130101) A61M 2205/502 (20130101) A61M 2205/702 (20130101) A61M 2205/3331 (20130101) A61M 2205/3334 (20130101) A61M 2205/3341 (20130101) A61M 2205/3351 (20130101) A61M 2205/3355 (20130101) A61M 2205/3365 (20130101) A61M 2205/3368 (20130101)
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10835755 — Method of using laser-induced optoacoustics for the treatment of drug-resistant microbial infections

US 10835755	Millenbaugh et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Bureau of Medicine and Surgery (BUMED) Naval Medical Research Center (NMRC)
APPLICANT(S)	Naval Medical Research Center (Silver Spring, Maryland)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Nancy J. Millenbaugh (San Antonio, Texas); Mauris DeSilva (Burnsville, Texas); Jonathan Baskin (San Antonio, Texas); William R Elliot (San Antonio, Texas)
ABSTRACT	The present invention is related to novel functional antibody coated nanoparticles, and the preparation method thereof. The functional antibody coated nanoparticles according to the present invention can be used as photothermal agents to effectively inhibit the growth of microbes including drug-resistant strains and biolfilm with laser irradiation.
FILED	Tuesday, May 08, 2018
APPL NO	15/974294
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 41/0052 (20130101) A61K 45/06 (20130101) A61K 47/6835 (20170801) A61K 47/6923 (20170801) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 5/0624 (20130101) A61N 2005/067 (20130101)
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10836135 — Three-dimensional multi-reinforced composites and methods of manufacture and use thereof

US 10836135	Xu
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S)	Florida State University Research Foundation, Inc. (Tallashassee, Florida)
INVENTOR(S)	Chengying Xu (Tallahassee, Florida)
ABSTRACT	Composite materials are provided which may include one or more sheets of carbon fibers woven in orthogonal direction bundles; carbon nanotubes embedded within pores between the bundles; and a matrix material in which the one or more sheets and the carbon nanotubes are embedded. In one case, the carbon fibers lie substantially in an x-direction and a y-direction and the carbon nanotubes are oriented substantially in a z-direction, which is substantially perpendicular to the x- and y-directions. Methods for making the composite materials are also provided.
FILED	Monday, October 05, 2015
APPL NO	14/874818
ART UNIT	1789 — Miscellaneous Articles, Stock Material
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/00 (20130101) B32B 5/06 (20130101) B32B 5/08 (20130101) B32B 5/024 (20130101) B32B 5/26 (20130101) Original (OR) Class B32B 38/08 (20130101) B32B 2260/04 (20130101) B32B 2260/021 (20130101) B32B 2260/023 (20130101) B32B 2260/046 (20130101) B32B 2262/12 (20130101) B32B 2262/106 (20130101) B32B 2307/20 (20130101) B32B 2307/54 (20130101) B32B 2307/202 (20130101) B32B 2307/302 (20130101) B32B 2307/546 (20130101) B32B 2307/558 (20130101) B32B 2309/68 (20130101) B32B 2313/04 (20130101)
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10836427 — Drive configurations for skid steered vehicles

US 10836427	Flaxman
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	QINETIQ LIMITED (Hampshire, United Kingdom)
ASSIGNEE(S)	QINETIQ LIMITED (Hampshire, United Kingdom)
INVENTOR(S)	Robert John Bonner Flaxman (Guildford, United Kingdom)
ABSTRACT	Some embodiments are directed to a drive configuration for a skid steered vehicle includes first and second torque outputs coupled by a differential and in a torque connection with first and second electric motors, the differential being configured to mechanically transfer power across itself; and a mechanical power splitter having a first torque transfer feature in a torque connection with a combustion engine, a second torque transfer feature in a torque connection with a respective additional electric motor and a third torque transfer feature in a torque connection with at least one of the first and second torque outputs of the drive configuration, wherein torque output from the or each the mechanical power splitter in use is dependent on torques generated by the combustion engine and the associated additional electric motor.
FILED	Thursday, March 16, 2017
APPL NO	16/303127
ART UNIT	3659 — Material and Article Handling
CURRENT CPC	Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 17/16 (20130101) B60K 23/04 (20130101) B60K 2006/4816 (20130101) B60K 2023/043 (20130101) Motor Vehicles; Trailers B62D 11/16 (20130101) B62D 11/183 (20130101) Original (OR) Class Gearing F16H 48/36 (20130101)
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10836466 — Toroidal propeller

US 10836466	Sebastian et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Thomas Sebastian (Maynard, Massachusetts); Christopher Strem (Ellicott City, Maryland)
ABSTRACT	The propeller includes a hub supporting a plurality of elongate propeller elements in which a tip of a leading propeller element curves into contact with a trailing propeller element to form a closed structure with increased stiffness and reduced acoustic signature.
FILED	Monday, November 06, 2017
APPL NO	15/803961
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Aeroplanes; Helicopters B64C 11/02 (20130101) B64C 11/008 (20130101) Original (OR) Class B64C 11/18 (20130101) B64C 11/20 (20130101) B64C 39/024 (20130101) B64C 2201/108 (20130101) B64C 2201/162 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/16 (20130101) F01D 5/141 (20130101) F01D 5/147 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/307 (20130101)
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10836810 — Monoclonal antibodies and cocktails for treatment of ebola infections

US 10836810	Bornholdt et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	MAPP BIOPHARMACEUTICAL, INC. (San Diego, California); Albert Einstein College of Medicine (Bronx, New York); Adimab, LLC (Lebanon, New Hampshire)
ASSIGNEE(S)	MAPP BIOPHARMACEUTICAL, INC. (San Diego, California); ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York); ADIMAB, LLC (Lebanon, New Hampshire)
INVENTOR(S)	Zachary A. Bornholdt (Encinitas, California); Larry Zeitlin (San Diego, California); Kartik Chandran (Brooklyn, New York); Anna Wec (Lebanon, New Hampshire); Laura Walker (Norwich, Vermont)
ABSTRACT	Described herein are compositions and methods for the prevention and treatment of ebolavirus infection certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
FILED	Saturday, February 17, 2018
APPL NO	15/898524
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 2039/55 (20130101) A61K 2039/57 (20130101) A61K 2039/62 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) A61K 2039/6075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/76 (20130101)
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10836874 — High performance cross-linked triblock cationic functionalized polymer for electrochemical applications, methods of making and methods of using

US 10836874	Herring et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Multidisciplinary University Research Initiative (MURI)
APPLICANT(S)	Andrew M. Herring (Boulder, Colorado); Mei-Chen Kuo (Denver, Colorado); E. Bryan Coughlin (Amherst, Massachusetts); Nora Buggy (Golden, Colorado); Yifeng Du (Amherst, Massachusetts)
ASSIGNEE(S)	Colorado School of Mines (Golden, Colorado); University of Massachusetts (Boston, Massachusetts)
INVENTOR(S)	Andrew M. Herring (Boulder, Colorado); Mei-Chen Kuo (Denver, Colorado); E. Bryan Coughlin (Amherst, Massachusetts); Nora Buggy (Golden, Colorado); Yifeng Du (Amherst, Massachusetts)
ABSTRACT	The present invention relates to a high performance cross-linked triblock cationic functionalized polymer for electrochemical applications, and methods of making and using the same. The invention also relates to a tunable hydrogenated polymer, that can be functionalized with a particular cation for a particular application, and the method of making the hydrogenated polymer and tuning the hydrogenated polymer for the application.
FILED	Tuesday, October 02, 2018
APPL NO	16/150113
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Separation B01D 71/80 (20130101) B01D 71/82 (20130101) B01D 2323/30 (20130101) B01D 2325/48 (20130101) Treatment or Chemical Modification of Rubbers C08C 19/22 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/04 (20130101) C08F 8/04 (20130101) C08F 8/04 (20130101) C08F 8/04 (20130101) C08F 8/04 (20130101) C08F 8/26 (20130101) C08F 8/32 (20130101) C08F 8/32 (20130101) C08F 8/32 (20130101) C08F 8/32 (20130101) C08F 8/34 (20130101) C08F 8/34 (20130101) C08F 8/40 (20130101) C08F 8/40 (20130101) C08F 8/40 (20130101) C08F 8/44 (20130101) C08F 8/44 (20130101) C08F 8/44 (20130101) C08F 8/44 (20130101) C08F 212/12 (20130101) C08F 212/14 (20130101) C08F 212/36 (20130101) C08F 232/00 (20130101) C08F 293/00 (20130101) C08F 293/00 (20130101) C08F 293/00 (20130101) C08F 293/00 (20130101) C08F 293/005 (20130101) C08F 293/005 (20130101) C08F 299/00 (20130101) C08F 2438/02 (20130101) C08F 2438/03 (20130101) C08F 2810/20 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 3/28 (20130101) C08J 3/246 (20130101) Original (OR) Class C08J 7/12 (20130101) C08J 2325/16 (20130101) C08J 2325/18 (20130101) C08J 2353/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/19 (20130101) C08K 5/3415 (20130101) C08K 5/3435 (20130101)
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10836987 — Microfluidic device having offset, high-shear seeding channels

US 10836987	Domansky et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S)	Karel Domansky (Charlestown, Massachusetts); Christopher David Hinojosa (Cambridge, Massachusetts); Donald E. Ingber (Boston, Massachusetts); Daniel Levner (Brookline, Massachusetts); Guy Thompson, II (Watertown, Massachusetts)
ABSTRACT	A microfluidic device for determining a response of cells comprises a microchannel and a seeding channel. The microchannel is at least partially defined by a porous membrane having cells adhered thereto. The microchannel has a first cross-sectional area. The seeding channel delivers a working fluid to the cells within the microchannel. The seeding channel has a second cross-sectional area that is less than the first cross-sectional area such that a flow of the working fluid produces a substantially higher shear force within the seeding channel to inhibit the attachment of cells within the seeding channel. And when multiple seeding channels are used to deliver fluids to multiple microchannels that define an active cellular layer across the membrane, the seeding channels are spatially offset from each other such that fluid communication between the fluids occurs only at the active region via the membrane, not at the seeding channels.
FILED	Friday, April 08, 2016
APPL NO	15/566566
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2300/0887 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) C12M 29/14 (20130101) C12M 35/04 (20130101) C12M 35/08 (20130101) C12M 41/00 (20130101)
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10837130 — Incandescent tension annealing processes for strong, twist-stable carbon nanotube yarns and muscles

US 10837130	Di et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Army (DOA) Department of the Navy (DON) Office of Naval Research (ONR) Multidisciplinary University Research Initiative (MURI) Non-Profit Organization (NPO) Robert A. Welch Foundation National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Jiangtao Di (Dallas, Texas); Shaoli Fang (Richardson, Texas); Carter S. Haines (Murphy, Texas); Na Li (Dallas, Texas); Ray H. Baughman (Dallas, Texas)
ABSTRACT	The described incandescent tension annealing processes involve thermally annealing twisted or coiled carbon nanotube (CNT) yarns at high-temperatures (1000° C. to 3000° C.) while these yarns are under tensile loads. These processes can be used for increasing yarn modulus and strength and for stabilizing both twisted and coiled CNT yarns with respect to unwanted irreversible untwist, thereby avoiding the need to tether torsional and tensile artificial muscles, and increasing the mechanical loads that can be moved by these muscles.
FILED	Thursday, April 27, 2017
APPL NO	15/498882
ART UNIT	3732 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/02 (20130101) D02G 3/04 (20130101) D02G 3/26 (20130101) Finishing or Dressing of Filaments, Yarns, Threads, Cords, Ropes or the Like D02J 1/22 (20130101) D02J 1/224 (20130101) Original (OR) Class D02J 11/00 (20130101) D02J 13/00 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 10/00 (20130101) D06M 2101/40 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2509/00 (20130101)
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10837139 — Durable polymer-aerogel based superhydrophobic coatings: a composite material

US 10837139	Kissel et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	David J. Kissel (Andover, Massachusetts); Charles Jeffrey Brinker (Albuquerque, New Mexico)
ASSIGNEE(S)	UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico)
INVENTOR(S)	David J. Kissel (Andover, Massachusetts); Charles Jeffrey Brinker (Albuquerque, New Mexico)
ABSTRACT	Provided are polymer-aerogel composite coatings, devices and articles including polymer-aerogel composite coatings, and methods for preparing the polymer-aerogel composite. The exemplary article can include a surface, wherein the surface includes at least one region and a polymer-aerogel composite coating disposed over the at least one region, wherein the polymer-aerogel composite coating has a water contact angle of at least about 140° and a contact angle hysteresis of less than about 1°. The polymer-aerogel composite coating can include a polymer and an ultra high water content catalyzed polysilicate aerogel, the polysilicate aerogel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.
FILED	Monday, December 28, 2015
APPL NO	14/981400
ART UNIT	1789 — Miscellaneous Articles, Stock Material
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 55/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) C08K 9/06 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/006 (20130101) C09D 5/14 (20130101) C09D 5/165 (20130101) C09D 5/1681 (20130101) C09D 7/62 (20180101) C09D 133/12 (20130101) Wall, Floor, or Like Covering Materials, e.g Linoleum, Oilcloth, Artificial Leather, Roofing Felt, Consisting of a Fibrous Web Coated With a Layer of Macromolecular Material; Flexible Sheet Material Not Otherwise Provided for D06N 3/0043 (20130101) Original (OR) Class D06N 3/0063 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2401/10 (20130101) D10B 2401/13 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24999 (20150401) Y10T 428/249953 (20150401) Y10T 428/249972 (20150401) Y10T 428/249991 (20150401) Y10T 442/20 (20150401)
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10837302 — Blade track assembly, components, and methods

US 10837302	Smith et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
ASSIGNEE(S)	Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
INVENTOR(S)	Clayton C. Smith (Fillmore, Indiana); George F. Griffiths (Carmel, Indiana); Ted Joseph Freeman (Avon, Indiana); William Westphal (Avon, Indiana)
ABSTRACT	A blade track assembly is disclosed having a variety of features. The assembly can have annular or segmented components, or a combination of the two. In one form the assembly includes blade tracks having a forward and aft edge that can be received in an opening of respective hangers. The hangers can include anti-movement features to discourage movement of a blade track. A rib can extend between hangers and in one form can be used as part of a seal assembly. Clips can be used to secure the blade track in openings of the respective hangers, as well as to discourage movement of the blade track.
FILED	Tuesday, September 05, 2017
APPL NO	15/695476
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/005 (20130101) F01D 11/08 (20130101) Original (OR) Class F01D 25/24 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/60 (20130101) F05D 2240/11 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/672 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/4932 (20150115)
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10837357 — Main bearings of opposed-piston engines with two crankshafts

US 10837357	Meckl et al.
FUNDED BY	Department of Defense (DOD) Defense Mobility Enterprise (DME) National Advanced Mobility Consortium (NAMC)
APPLICANT(S)	ACHATES POWER, INC. (San Diego, California)
ASSIGNEE(S)	Achates Power, Inc. (San Diego, California)
INVENTOR(S)	Paul Meckl (Gresham, Oregon); Gary A. Vrsek (San Diego, California); John Blacklock (San Diego, California)
ABSTRACT	A main bearing cap construction far a dual-crankshaft, opposed-piston engine has two sets of bolts in a cross-bolted configuration. In a dual-crankshaft opposed-piston engine with at least four main bearings, at least one of the main bearings will have a cap with two sets of bolts in a cross-bolted configuration. In addition to having a cross-bolted configuration, the main bearing cap configuration can have flanges to receive blind bolts and/or additional surface area to interface with the cylinder block.
FILED	Tuesday, July 23, 2019
APPL NO	16/520146
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Machines or Engines, in General or of Positive-displacement Type, e.g Steam Engines F01B 7/14 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 75/28 (20130101) Original (OR) Class Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 7/0053 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 9/02 (20130101) Gearing F16H 1/20 (20130101)
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10837396 — Torque-slewing diesel engine operation

US 10837396	Meininger et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Contracting Command (ACC) Redstone Arsenal (REDSTONE)
APPLICANT(S)	Science Applications International Corporation (Reston, Virginia); U.S. Government as Represented by the Secretary of the Army (Redstone Arsenal, Alabama)
ASSIGNEE(S)	Science Applications International Corporation (Reston, Virginia); U.S. Government as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Rik Denis Meininger (Huntsville, Alabama); Bernard Acker (Madison, Alabama)
ABSTRACT	An aircraft diesel engine may be operated at a minimal fuel rate. Shaft output power of the engine may be reduced by initiating combustion during the compression stroke. Combustion may be initiated during the compression stroke by advancing fuel injection, splitting fuel injection, and/or manipulating individual injection quantities. Initiating combustion during the compression stroke may slew torque generation to the compression stroke.
FILED	Tuesday, May 14, 2019
APPL NO	16/411799
ART UNIT	3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/08 (20130101) Controlling Combustion Engines F02D 35/00 (20130101) F02D 41/08 (20130101) F02D 41/402 (20130101) Original (OR) Class
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10837407 — Liquid fuel metering in a hybrid rocket-like liquid rocket motor

US 10837407	Fuller et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	Jerome Keith Fuller (Lake Balboa, California); John D DeSain (Redondo Beach, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Jerome Keith Fuller (Lake Balboa, California); John D DeSain (Redondo Beach, California)
ABSTRACT	A hybrid-like liquid fuel motor (the “motor”) may include a port surrounded by a wall. Surrounding the wall are a plurality of chambers and segmented walls to separate the chambers. In some instances, a single helix chamber may surround the wall, and may operate similar to that of a segmental chamber. During operation of the motor, gas flows from one end of the port to another end of the port. As the walls surrounding the port begin to disintegrate, liquid fuel within chambers begins to begin to mix with the flow of gas. As the segmented walls between the chambers begin to disintegrate, liquid from the other chambers begin to mix with the flow of gas, creating a metering of the liquid fuel.
FILED	Friday, November 04, 2016
APPL NO	15/343296
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/403 (20130101) B64G 1/404 (20130101) Jet-propulsion Plants F02K 9/10 (20130101) F02K 9/12 (20130101) F02K 9/16 (20130101) F02K 9/72 (20130101) Original (OR) Class F02K 9/605 (20130101)
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10837747 — High explosive firing mechanism

US 10837747	Wilson et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	GOODRICH CORPORATION (Charlotte, North Carolina)
ASSIGNEE(S)	GOODRICH CORPORATION (Charlotte, North Carolina)
INVENTOR(S)	Brian Wilson (Vacaville, California); Kevin Mueller (Dixon, California)
ABSTRACT	The present disclosure provides a high explosive firing mechanism. The high explosive firing mechanism may comprise a housing comprising a firing pin tube having a primer inlet. The high explosive firing mechanism may further comprise a firing pin disposed within the firing pin tube, the firing pin comprising a nub. The nub may partially extend into the primer inlet.
FILED	Thursday, February 15, 2018
APPL NO	15/897840
ART UNIT	3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 25/08 (20130101) Ammunition Fuzes; Arming or Safety Means Therefor F42C 7/00 (20130101) F42C 15/32 (20130101) F42C 15/34 (20130101) Original (OR) Class F42C 19/10 (20130101) Blasting F42D 1/043 (20130101)
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10837833 — Speckle enhanced spatial-domain spectrometer

US 10837833	Paudel et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Uttam Paudel (El Segundo, California); Todd S. Rose (El Segundo, California)
ABSTRACT	A speckle-enhanced discrete Fourier transform spectrometer can include waveguides configured to combine speckle spectroscopy techniques with discrete Fourier transform spectroscopy techniques. A discrete Fourier transform spectrometer section can be a compact, passive, chip-scale optical spectrometer. A speckle spectrometer section can include a multi-mode wave guide. An interference region can be in optical communication with both the discrete Fourier transform spectrometer section and the speckle spectrometer section such that light from both sections interfere in the interference region. A detector can be used to detect light from the interference region for detecting spectral content of light over a large bandwidth at a high resolution.
FILED	Friday, July 26, 2019
APPL NO	16/523869
ART UNIT	2886 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/45 (20130101) Original (OR) Class G01J 2003/451 (20130101)
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10838035 — Characterizing multipath delays in antenna array and synthetic aperture radar systems

US 10838035	Kumar et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Materiel Command (AFMC) Air Force Office of Scientific Research (AFOSR) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Swarun Suresh Kumar (Cambridge, Massachusetts); Dina Katabi (Cambridge, Massachusetts)
ABSTRACT	Multiple radio transmissions are processed to determine, for each of a number of directions of arrival of the radio transmissions, a most direct direction of arrival, for example, to distinguish a direct path from a reflected path from the target. In some examples, the radio transmissions include multiple frequency components, and channel characteristics at different frequencies are compared to determine the direct path.
FILED	Monday, December 22, 2014
APPL NO	14/579365
ART UNIT	3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 3/04 (20130101) G01S 3/14 (20130101) Original (OR) Class G01S 3/46 (20130101) G01S 3/48 (20130101) G01S 3/52 (20130101) G01S 3/72 (20130101) G01S 5/0273 (20130101) G01S 13/48 (20130101) G01S 13/9023 (20130101) G01S 13/9082 (20190501) G01S 19/14 (20130101) G01S 19/24 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/2601 (20130101) Wireless Communication Networks H04W 64/00 (20130101)
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10838065 — Localization using 2D maps which capture vertical structures in 3D point data

US 10838065	Olson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Office of Naval Research (ONR) Department of the Interior (DOI)
APPLICANT(S)	The Regents of The University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Edwin Olson (Ann Arbor, Michigan); Carl Kershaw (Ann Arbor, Michigan)
ABSTRACT	Autonomous vehicles require precise localization to support safe and reliable operation. Current systems aim to localize in 6DOF based on observations from a combination of cameras and 3D LiDAR, matching against dense, 3D prior maps. These maps are quite large and complex, presenting both computational and physical challenges in terms of matching, storage, and retrieval. Most of the environments where vehicles operate in contain frequent and distinct vertical structure sufficient for 2D localization, while state-of-the-art IMUs can be used to recover roll and pitch. This disclosure introduces a fast method for constructing 2D maps summarizing the vertical structure in the environment and demonstrate that it can be used to localize accurately in vehicular and other applications.
FILED	Friday, January 26, 2018
APPL NO	15/881026
ART UNIT	3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4808 (20130101) G01S 17/42 (20130101) G01S 17/89 (20130101) Original (OR) Class G01S 17/931 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00805 (20130101) Image Data Processing or Generation, in General G06T 11/206 (20130101)
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10838071 — Reducing user multipath error and acquisition time in satellite navigation receivers

US 10838071	Dybdal
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Robert B. Dybdal (Palos Verdes Estates, California)
ABSTRACT	Satellite navigation receivers are provided herein. In certain embodiments, a satellite navigation receiver correlates a received RF navigational signal from a satellite with a replica code generated by the receiver. Additionally, errors due to multipath are mitigated by identifying the location of the peak values of the correlation function obtained when the replica code is aligned with the received RF navigational signal. Thus, the peak correlation value is detected by sweeping the user replica code in delay in place of a closed loop early/late discriminator. Moreover, multiple copies of the receiver generated replica codes with different time offsets can be used to perform the acquisition in parallel. This advantageously reduces the amount of acquisition time to align the replica code and provides averaging to improve the accuracy in detecting the delay location of the peak correlation value.
FILED	Thursday, December 12, 2019
APPL NO	16/712000
ART UNIT	3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/22 (20130101) Original (OR) Class G01S 19/29 (20130101) G01S 19/30 (20130101)
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10838406 — Systems and methods for the patterning of material substrates

US 10838406	Livingston
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Frank Edward Livingston (Redondo Beach, California)
ABSTRACT	A system includes a computing device that generates at least one process script for the modification to a glass ceramic substrate and at least one pattern script that corresponds to the process script. The computing device also merges the process script with the pattern script and generates a plurality of command signals that are based on the merged process and pattern scripts. An energy source generates a plurality of light beams based on the generated command signal(s). A waveform apparatus generates at least one waveform signal to customize the generated light beams based on the generated command signal(s). At least one modulating component modulates the generated light beams based on generated command signal(s). An optical assembly is configured to apply the modulated plurality of light beams to the glass ceramic substrate. At least one motion stage encoder is configured to provide at least one three dimensional (3D) coordinate position of the optical assembly with respect to the motion control drive in order to coordinate application of the modulated light beams with a predefined spatial location.
FILED	Tuesday, August 21, 2018
APPL NO	16/108050
ART UNIT	2118 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4155 (20130101) Original (OR) Class G05B 2219/45041 (20130101)
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10838427 — Vision-aided inertial navigation with loop closure

US 10838427	Madison et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Contracting Command (ACC) Aberdeen Proving Ground (APG) Combat Capabilities Development Command (CCDC) Communications-Electronics Research, Development and Engineering Center (CERDEC) Research, Development and Engineering Command (RDECOM)
APPLICANT(S)	The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)	The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts)
INVENTOR(S)	Richard W. Madison (Bedford, Massachusetts); Melanie K. Stich (Cambridge, Massachusetts)
ABSTRACT	A vision-aided inertial navigation system determines navigation solutions for a traveling vehicle. A navigation solution module analyzes image sensor poses and estimated inertial navigation solutions to produce a time sequence of system navigation solution outputs that represent changing locations of the traveling vehicle. A loop closure detector performs a two-threshold image classification to classify an incoming navigation image as novel, loop-closing, or neither, and the navigation solution module resets the navigation solution output to represent a previous location when the loop closure detector classifies an incoming navigation image as loop-closing.
FILED	Thursday, October 26, 2017
APPL NO	15/794339
ART UNIT	3619 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/165 (20130101) G01C 22/00 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/027 (20130101) G05D 1/0253 (20130101) Original (OR) Class G05D 1/0272 (20130101)
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10838804 — Interference suppression using repeated reduced rank adaptive filtering in Fractional Fourier Transform (FrFT) domains

US 10838804	Sud
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) The Aerospace Corporation (AEROSPACE) Federally Funded Research and Development Center (FFRDC) Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S)	The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S)	The Aerospace Corporation (El Segundo, California)
INVENTOR(S)	Seema Sud (Reston, Virginia)
ABSTRACT	A signal-of-interest (SOI) may be separated from interference and/or noise using repeated reduced rank minimum mean-square error Fractional Fourier Transform (MMSE-FrFT) filtering and a low rank adaptive multistage Wiener filter (MWF). A number of stages in the MWF, L, may be chosen such that at the L^thstage, the MSE between the SOI estimate and the true SOI is less than or equal to an error threshold ϵ (e.g., ϵ=0.001). By combining these filtering techniques, significant improvement in reducing the mean-square error (MSE) may be realized over single stage MMSE-FrFT, repeated MMSE-FrFT, and MMSE-FFT algorithms—indeed, by an order of magnitude or more.
FILED	Tuesday, May 28, 2019
APPL NO	16/423211
ART UNIT	2111 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Electric Digital Data Processing G06F 7/48 (20130101) G06F 11/0751 (20130101) G06F 11/0754 (20130101) G06F 11/0793 (20130101) Original (OR) Class Impedance Networks, e.g Resonant Circuits; Resonators H03H 17/0213 (20130101) H03H 21/0043 (20130101) H03H 2021/0094 (20130101)
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10838971 — Method and system for an ontology, including a representation of unified medical language system (UMLS) using simple knowledge organization system (SKOS)

US 10838971	Mirhaji
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Parsa Mirhaji (Pearland, Texas)
ABSTRACT	Embodiments of an informatics platform where collected data can be normalized, integrated and mapped to a knowledge source, such as medical vocabulary systems are disclosed. One example of such a knowledge source is Unified Medical Language System (UMLS) which is a knowledge source for biomedical applications. Embodiments as depicted herein may provided a method to convert the desired information from UMLS into an ontology representation to allow for its use in conjunction with an informatics system.
FILED	Tuesday, October 11, 2016
APPL NO	15/290064
ART UNIT	2122 — AI & Simulation/Modeling
CURRENT CPC	Electric Digital Data Processing G06F 16/22 (20190101) G06F 16/248 (20190101) G06F 16/367 (20190101) G06F 16/2465 (20190101) Original (OR) Class G06F 16/3329 (20190101) G06F 16/3344 (20190101) G06F 16/9024 (20190101) G06F 40/211 (20200101) G06F 40/253 (20200101) G06F 40/284 (20200101) G06F 40/289 (20200101) Computer Systems Based on Specific Computational Models G06N 5/02 (20130101)
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10839109 — Integrated circuit (IC) portholes and related techniques

US 10839109	Bush et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Kevin B. Bush (Sudbury, Massachusetts); Matthew D. Hicks (Blacksburg, Virginia); Timothy D. Trippel (Mishawaka, Indiana)
ABSTRACT	An integrated circuit (IC) structure includes a device layer including a security-critical wire and a metal layer disposed over the device layer. The metal layer includes at least one wire and an IC porthole. The IC porthole has a perimeter that defines a shape such that, when the perimeter of the IC porthole is projected onto the device layer, the projection of the IC porthole perimeter includes at least a segment of the security-critical wire, and the at least one wire in the metal layer does not overlap the security-critical wire within the projection of the IC porthole perimeter to thereby allow post-fabrication optical inspection of the security-critical wire through the IC porthole.
FILED	Wednesday, October 09, 2019
APPL NO	16/597013
ART UNIT	2899 — Semiconductors/Memory
CURRENT CPC	Electric Digital Data Processing G06F 21/56 (20130101) G06F 21/70 (20130101) G06F 21/71 (20130101) G06F 21/73 (20130101) G06F 21/86 (20130101) Original (OR) Class G06F 21/87 (20130101) G06F 21/88 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/552 (20130101) H01L 23/576 (20130101) H01L 23/5386 (20130101) H01L 23/49822 (20130101) H01L 23/49838 (20130101) H01L 2224/05568 (20130101) Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 43/28 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/002 (20130101) H04L 29/06877 (20130101) H04L 63/14 (20130101) H04L 63/145 (20130101) H04L 63/1441 (20130101) Telephonic Communication H04M 3/2281 (20130101) Pictorial Communication, e.g Television H04N 21/44236 (20130101) Wireless Communication Networks H04W 12/1208 (20190101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 707/952 (20130101)
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10839287 — Globally asynchronous and locally synchronous (GALS) neuromorphic network

US 10839287	Alvarez-Icaza Rivera et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Rodrigo Alvarez-Icaza Rivera (Mountain View, California); John V. Arthur (Mountain View, California); Andrew S. Cassidy (Austin, Texas); Paul A. Merolla (Palo Alto, California); Dharmendra S. Modha (San Jose, California)
ABSTRACT	Embodiments of the invention relate to a globally asynchronous and locally synchronous neuromorphic network. One embodiment comprises generating a synchronization signal that is distributed to a plurality of neural core circuits. In response to the synchronization signal, in at least one core circuit, incoming spike events maintained by said at least one core circuit are processed to generate an outgoing spike event. Spike events are asynchronously communicated between the core circuits via a routing fabric comprising multiple asynchronous routers.
FILED	Monday, October 29, 2018
APPL NO	16/173749
ART UNIT	2123 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Original (OR) Class G06N 3/049 (20130101) G06N 3/063 (20130101)
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10839297 — System and method for configuration of an ensemble solver

US 10839297	Ezick et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Army (DOA) Space and Missile Defense Command (SMDC) Missile Defense Agency (MDA)
APPLICANT(S)	Reservoir Labs, Inc. (New York, New York)
ASSIGNEE(S)	Reservoir Labs, Inc. (New York, New York)
INVENTOR(S)	James Ezick (Canonsburg, Pennsylvania); Jonathan Springer (Carbondale, Illinois); Nicolas T. Vasilache (New York, New York)
ABSTRACT	In a system for enabling configuration of an ensemble of several solvers, such that the ensemble can efficiently solve a constraint problem, for each one of several candidate configurations, an array of scores is computed. The array corresponds to a statistical parameter related to a problem solution, and the computation is based on, at least in part, a set of features associated with the problem. One candidate configuration is assigned to a solver, and based on the array of scores associated with that candidate configuration the same or a different candidate configuration is assigned to a another solver. A system for dynamically reconfiguring an ensemble of solvers obtains runtime data from several solvers, and a new configuration is determined by applying a machine learning and/or heuristic analysis procedure to the runtime data. The configuration of a solver may be updated according to the new configuration while that solver is running.
FILED	Thursday, June 08, 2017
APPL NO	15/617602
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) Original (OR) Class G06N 20/00 (20190101)
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10839302 — Approximate value iteration with complex returns by bounding

US 10839302	Wright et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	The Research Foundation for The State University of New York (Binghamton, New York)
ASSIGNEE(S)	The Research Foundation for the State University of New York (Binghamton, New York)
INVENTOR(S)	Robert Wright (Sherrill, New York); Lei Yu (Vestal, New York); Steven Loscalzo (Vienna, Virginia)
ABSTRACT	A control system and method for controlling a system, which employs a data set representing a plurality of states and associated trajectories of an environment of the system; and which iteratively determines an estimate of an optimal control policy for the system. The iterative process performs the substeps, until convergence, of estimating a long term value for operation at a respective state of the environment over a series of predicted future environmental states; using a complex return of the data set to determine a bound to improve the estimated long term value; and producing an updated estimate of an optimal control policy dependent on the improved estimate of the long term value. The control system may produce an output signal to control the system directly, or output the optimized control policy. The system preferably is a reinforcement learning system which continually improves.
FILED	Tuesday, November 22, 2016
APPL NO	15/359122
ART UNIT	2125 — AI & Simulation/Modeling
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/0265 (20130101) G05B 15/02 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Original (OR) Class G06N 20/00 (20190101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 10/30 (20130101)
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10839311 — Cognitive computing for servers and mobile devices

US 10839311	Bose et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	Pradip Bose (Yorktown Heights, New York); Alper Buyuktosunoglu (White Plains, New York); Augusto Javier Vega (Astoria, New York)
ABSTRACT	Techniques for decoupling cognitive model training from execution of the cognitive model are provided. In one example, a computer program product is provided that determines cognitive data based on context data and a model of interpreting the context data. The cognitive data can comprise prediction data that represents a prediction relating to a state of an environment. The context data and the cognitive data can be transmitted to a server, and an updated model can be received in response.
FILED	Tuesday, July 19, 2016
APPL NO	15/214092
ART UNIT	2126 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Original (OR) Class
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10839508 — Integrated circuit image alignment and stitching

US 10839508	Zhang et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)	SRI International (Menlo Park, California)
INVENTOR(S)	David Zhang (Belle Mead, New Jersey); Sek Meng Chai (Princeton, New Jersey); Erik Matlin (San Jose, California)
ABSTRACT	In general, techniques are described for processing a set of high-resolution images of an integrated circuit, the images captured at different locations with respect to the integrated circuit, to automatically align and “stitch” the set of high-resolution images into a larger composite image. For example, an imaging system as described herein may use sampled feature points distributed across different grid tiles within overlap regions for pairs of images to match feature points to inform the alignments of a pair with respect to each image in the pair. The system may in some cases further apply a bundle adjustment to iteratively align and refine the alignment results for each image in a set of images being processed. In some examples, the bundle adjustment is a best-fit adjustment based on minimizing the net error associated with the alignment of the set of images.
FILED	Monday, April 22, 2019
APPL NO	16/390885
ART UNIT	2664 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/03 (20130101) G06K 9/6256 (20130101) Image Data Processing or Generation, in General G06T 7/001 (20130101) Original (OR) Class G06T 7/248 (20170101) G06T 7/337 (20170101) G06T 11/60 (20130101) G06T 2207/10061 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30148 (20130101)
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10839513 — Distinguishing hyperprogression from other response patterns to PD1/PD-L1 inhibitors in non-small cell lung cancer with pre-therapy radiomic features

US 10839513	Vaidya et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) U.S. Army Medical Research and Materiel Command (USAMRMC) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Center for Research Resources (NCRR)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Pranjal Vaidya (Cleveland, Ohio); Kaustav Bera (Cleveland, Ohio); Vamsidhar Velcheti (Pepper Pike, Ohio); Anant Madabhushi (Shaker Heights, Ohio)
ABSTRACT	Embodiments access a pre-immunotherapy image of tissue demonstrating NSCLC including a tumor and a peritumoral region; extract a first set of radiomic features from the image; provide the first set of radiomic features to a first machine learning classifier; receive a first probability from the first classifier that the tissue is hyperprogressor (HP) or non-responder (R); if the first probability that the tissue is within a threshold: generate a first classification of the ROT as HP or non-R based on the first probability; if the first probability is not within the threshold: extract a second set of radiomic features from the peritumoral region and provide the second set to a second machine learning classifier; receive a second probability from the second classifier that the tissue is HP or R; generate a second classification of the tissue as HP or R based on the second probability; and display the classification.
FILED	Monday, March 11, 2019
APPL NO	16/297889
ART UNIT	2664 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) G06K 9/6262 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) G06N 20/20 (20190101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/136 (20170101) G06T 2207/10081 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20152 (20130101) G06T 2207/30061 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101)
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10839515 — Systems and methods for generating and displaying OCT angiography data using variable interscan time analysis

US 10839515	Moult et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Eric M. Moult (Cambridge, Massachusetts); James G. Fujimoto (Medford, Massachusetts); Stefan B. Ploner (Langensendelbach, Germany); Woo J. Choi (Seoul, South Korea)
ABSTRACT	An imaging (e.g., with an optical coherence tomography system) method that includes 1) acquiring repeated B-scans in a manner consistent with forming images, 2) processing the acquired images according to a variable interscan time analysis (VISTA) method, and 3) generating and displaying a color-mapped image pixel color of the color-mapped image fluid flow speed, or a related quantity.
FILED	Friday, April 27, 2018
APPL NO	15/964917
ART UNIT	2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/0041 (20130101) A61B 3/102 (20130101) Image Data Processing or Generation, in General G06T 5/50 (20130101) G06T 7/0016 (20130101) Original (OR) Class G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) G06T 2207/10101 (20130101)
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10839880 — Low power sense amplifier based on phase transition material

US 10839880	Gupta et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Sumeet Kumar Gupta (State College, Pennsylvania); Ahmedullah Aziz (State College, Pennsylvania); Nikhil Shukla (South Bend, Indiana); Suman Datta (South Bend, Indiana); Xueqing Li (State College, Pennsylvania); Vijaykrishnan Narayanan (University Park, Pennsylvania)
ABSTRACT	A sense amplifier utilizes a phase transition material (PTM) in conjunction with CMOS circuits to provide a precise sensing threshold. The sense amplifier can be used in memory applications to sense states of stored bits with high accuracy and robustness. In one sense amplifier, a first diode-connected transistor has gate and drain nodes coupled to an input node of the sense amplifier, a second transistor has a gate node coupled to the gate node of the first diode-connected transistor, and the PTM is coupled to the source node of the second transistor. In another sense amplifier, a first transistor has a gate node coupled to an input node of the sense amplifier, a PTM is coupled to the source node of the first transistor, and an output stage including an inverter is coupled between a drain node of the first transistor and an output node of the sense amplifier.
FILED	Thursday, January 31, 2019
APPL NO	16/263644
ART UNIT	2825 — Semiconductors/Memory
CURRENT CPC	Static Stores G11C 7/062 (20130101) G11C 11/1673 (20130101) Original (OR) Class G11C 13/0002 (20130101) G11C 13/004 (20130101) G11C 13/0007 (20130101)
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10840573 — Linear-to-circular polarizers using cascaded sheet impedances and cascaded waveplates

US 10840573	Tomasic et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of the Air Force (Washington, District of Columbia)
INVENTOR(S)	Boris Tomasic (Harvard, Massachusetts); Carl R. Pfeiffer (Beavercreek, Ohio); Thomas P. Steffen (Xenia, Ohio)
ABSTRACT	An ultra-wideband linear-to-circular polarizer is disclosed. In accordance with embodiments of the invention, the polarizer includes a plurality of cascaded waveplates having biaxial permittivity or cascaded anisotropic sheet impedances. Each waveplate/sheet has a principal axis rotated at different angles relative to an adjacent waveplate/sheet about a z-axis of a 3-dimensional x, y, z coordinate system. Each waveplate is composed of a unit cell of an artificial anisotropic dielectric. Each sheet impedance is composed of an anisotropic metallic pattern. The polarizer further includes impedance matching layers disposed adjacent the cascaded waveplates/sheets.
FILED	Tuesday, November 06, 2018
APPL NO	16/181624
ART UNIT	2843 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 27/286 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/17 (20130101) Original (OR) Class H01P 1/171 (20130101) H01P 1/172 (20130101) H01P 1/173 (20130101) H01P 11/00 (20130101) Antennas, i.e Radio Aerials H01Q 3/40 (20130101) H01Q 3/2676 (20130101) H01Q 5/335 (20150115) H01Q 15/04 (20130101) H01Q 15/24 (20130101) H01Q 15/244 (20130101) H01Q 15/246 (20130101) H01Q 21/0031 (20130101) H01Q 21/064 (20130101)
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10840811 — System and method for power conversion

US 10840811	Fogel et al.
FUNDED BY	Department of Defense (DOD)
APPLICANT(S)	Accion Systems, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Accion Systems, Inc. (Boston, Massachusetts)
INVENTOR(S)	Paul Fogel (Boston, Massachusetts); Mikhail Filippov (Boston, Massachusetts)
ABSTRACT	A polarity-selectable high voltage direct current power supply including a first drive assembly that transforms a first low voltage DC input into a first medium voltage alternating current output; a first HV output assembly that transforms the first LV AC output into a first HV DC output, wherein the first HV output assembly defines a first input stage; a polarity selector coupled between the second output junction of the first drive assembly and the first and second input stages of the first HV output assembly, the polarity selector operable between a first configuration and a second configuration; wherein in the first configuration the first HV DC output has a positive polarity; and wherein in the second configuration the first HV DC output has a negative polarity.
FILED	Tuesday, April 16, 2019
APPL NO	16/385709
ART UNIT	2896 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 27/022 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/335 (20130101) Original (OR) Class H02M 2001/008 (20130101)
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10840925 — Harmonic injection locking apparatus, methods, and applications

US 10840925	Delfyett et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Direct On-Chip Digital Optical Synthesizer Program (DODOS) National Science Foundation (NSF)
APPLICANT(S)	University of Central Florida Research Foundation, Inc. (Orlando, Florida)
ASSIGNEE(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
INVENTOR(S)	Peter J. Delfyett (Orlando, Florida); Ricardo Bustos Ramirez (Orlando, Florida); Michael E. Plascak (Orlando, Florida)
ABSTRACT	Apparatus and methods demonstrate a chip-scale direct optical to RF link that frequency divides up to 120 GHz optical frequency combs to 10 GHz using harmonic multi-tone injection locking. The embodied invention links widely separated optical frequency combs in the millimeter wave regime (>120 GHz) or THz domain (100s of GHz to THz domain), e.g., microresonator-based frequency combs, which are currently outside of the photo-detection region, into the microwave domain (10s of GHz) where it can be easily photo-detected and controlled. The technique works as a perfect optical divider, using a mode-locked laser and optical injection locking as the technique to phase-lock both lasers.
FILED	Monday, May 13, 2019
APPL NO	16/410401
ART UNIT	2849 — Electrical Circuits and Systems
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1121 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/20 (20130101) Original (OR) Class
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D0902359 — Lifting plug

US D902359	Wu et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	U.S. Government as Represented by the Secretary of the Army (Dover, New Jersey)
ASSIGNEE(S)	The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Thomas Wu (New Hyde Park, New York); Shana Groeschler (Highland Park, New Jersey); Keith Fulton (Stroudsburg, Pennsylvania); Leon Moy (Verona, New Jersey)
ABSTRACT
FILED	Thursday, November 29, 2018
APPL NO	29/671685
ART UNIT	2919 — Design
CURRENT CPC	Environmental heating and cooling; fluid handling and sanitary equipment D23/260
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Department of Energy (DOE)

10834886 — Switchgrass cultivar PanIR

US 10834886	Baldwin et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	Brian S. Baldwin (Starkville, Mississippi); Jason Brett Rushing (Newton, Mississippi)
ASSIGNEE(S)	Mississippi State University (Mississippi State, Mississippi)
INVENTOR(S)	Brian S. Baldwin (Starkville, Mississippi); Jason Brett Rushing (Newton, Mississippi)
ABSTRACT	A novel herbicide-resistant switchgrass cultivar, designated PanIR, is disclosed. The invention relates to the seeds of switchgrass cultivar PanIR, to the plants of switchgrass cultivar PanIR, and to methods for producing a switchgrass plant produced by crossing the cultivar PanIR with itself or another switchgrass variety. The invention relates to plant parts derived from switchgrass cultivar PanIR and to methods for producing other switchgrass cultivars, lines, or plant parts derived from switchgrass cultivar PanIR. The invention further relates to hybrid switchgrass seeds and plants produced by crossing the switchgrass cultivar PanIR with another switchgrass cultivar. It also further relates to other derivatives of the cultivar PanIR, methods of producing imazapic resistant switchgrass seeds and plants, and to producing commodity plant products.
FILED	Saturday, June 23, 2018
APPL NO	16/016594
ART UNIT	1662 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/10 (20130101) A01H 6/4642 (20180501) Original (OR) Class
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10835847 — Polymeric membranes for separation of gases

US 10835847	Ho et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
ASSIGNEE(S)	Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S)	W.S. Winston Ho (Columbus, Ohio); Yuanxin Chen (Columbus, Ohio)
ABSTRACT	Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a gas permeable support layer, optionally an inorganic layer disposed on the support, and a selective polymer layer disposed on the inorganic layer. In some cases, the selective polymer layer can comprise an amine-containing polymer and an amino acid salt dispersed within the amine-containing polymer. In other cases, the selective polymer layer comprises a sterically hindered amine-containing polymer, such as a sterically hindered derivative of polyvinylamine. The membranes can be used, for example, to separate gaseous mixtures, such as flue gas.
FILED	Tuesday, May 31, 2016
APPL NO	15/577954
ART UNIT	1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 39/1623 (20130101) Original (OR) Class B01D 39/1692 (20130101) B01D 53/228 (20130101) B01D 69/10 (20130101) B01D 69/12 (20130101) B01D 69/142 (20130101) B01D 69/148 (20130101) B01D 71/44 (20130101) B01D 2239/0654 (20130101)
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10835959 — Atomizer for improved ultra-fine powder production

US 10835959	Rieken et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Ames Laboratory (AL) Federally Funded Research and Development Center (FFRDC) Operated by Iowa State University (IASTATE) at Ames, IA
APPLICANT(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
INVENTOR(S)	Joel R. Rieken (Carmel, Indiana); Andrew J. Heidloff (Carmel, Indiana); Iver E. Anderson (Ames, Iowa)
ABSTRACT	A concentric ring gas atomization nozzle with isolated gas supply manifolds is provided for manipulating the close-coupled atomization gas structure to improve the yield of atomized powders.
FILED	Wednesday, May 02, 2018
APPL NO	15/932837
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/02 (20130101) B22F 9/082 (20130101) Original (OR) Class B22F 2009/0832 (20130101) B22F 2009/0892 (20130101) Alloys C22C 32/0026 (20130101) C22C 38/002 (20130101) C22C 38/005 (20130101) C22C 38/06 (20130101) C22C 38/22 (20130101)
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10836132 — Graphene reinforced materials and related methods of manufacture

US 10836132	Vlassiouk et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Ivan V. Vlassiouk (Oak Ridge, Tennessee); Ilia N. Ivanov (Knoxville, Tennessee); Panagiotis G. Datskos (Knoxville, Tennessee)
ABSTRACT	Graphene reinforced materials and related methods of manufacture are provided. The graphene reinforced materials include graphene sheet or scroll, graphene-polymer sheet or scroll, and graphene-carbon sheet or scroll, each having material properties that are attractive across a broad range of applications and industries. The graphene reinforced materials generally include monolayer or multilayer graphene that is synthesized by annealing a catalyst substrate within a CVD chamber, introducing a hydrocarbon gas as a carbon source with the CVD chamber to form a layer of graphene on the catalyst substrate, detaching the catalyst substrate from the layer of graphene, and rolling the layer of graphene onto itself to form a scroll, optionally with the addition of a polymer layer or carbonized layer on the graphene layer.
FILED	Wednesday, September 19, 2018
APPL NO	16/135382
ART UNIT	1783 — Miscellaneous Articles, Stock Material
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 1/00 (20130101) Original (OR) Class B32B 15/08 (20130101) B32B 18/00 (20130101) B32B 2255/10 (20130101) B32B 2255/20 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/186 (20170801) C01B 32/194 (20170801) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/522 (20130101) C04B 35/62218 (20130101) C04B 2235/94 (20130101) C04B 2235/96 (20130101) C04B 2237/363 (20130101) Technical Subjects Covered by Former US Classification Y10T 156/1038 (20150115) Y10T 428/30 (20150115)
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10836638 — Metal phosphide nanomaterials prepared from single source metal amides

US 10836638	Kemp et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	STC.UNM (Albuquerque, New Mexico); SANDIA CORPORATION (Albuquerque, New Mexico)
ASSIGNEE(S)	UNM Rainforest Innovations (Albuquerque, New Mexico)
INVENTOR(S)	Richard Alan Kemp (Albuquerque, New Mexico); Diane Dickie (Albuquerque, New Mexico); Bernadette A. Hernandez-Sanchez (Albuquerque, New Mexico); Timothy N. Lambert (Albuquerque, New Mexico)
ABSTRACT	The present invention provides a novel solution or route for metal phosphide (MP_x) nanomaterials from the thermal decomposition of metal bis[bis(diisopropylphosphino)amide], M[N(PPri₂)₂]₂, and/or single-source precursors. Synthetic routes to MP_xnanomaterials may be used in energy applications including batteries, semiconductors, magnets, catalyst, lasers, inks, electrocatalysts and photodiodes.
FILED	Friday, April 08, 2016
APPL NO	15/565670
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 25/08 (20130101) Original (OR) Class C01B 25/082 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2004/04 (20130101) C01P 2004/64 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/5045 (20130101) Alloys C22C 1/00 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/81 (20130101) Y10S 977/773 (20130101) Y10S 977/825 (20130101) Y10S 977/896 (20130101)
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10836654 — Stable immobilized amine sorbents for removal of an organic contaminate from wastewater

US 10836654	Gray et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	United States Department of Energy (Washington, District of Columbia)
ASSIGNEE(S)	U.S. Department of Energy (Washington, District of Columbia)
INVENTOR(S)	McMahan L. Gray (Pittsburgh, Pennsylvania); Brian W. Kail (Pittsburgh, Pennsylvania); Qiuming Wang (South Park, Pennsylvania); Walter C. Wilfong (Clinton, Pennsylvania)
ABSTRACT	The present disclosure relates to a method for the removal of organic contaminates from wastewater. The method comprises contacting wastewater comprising water and an organic contaminate with a basic immobilized amine sorbent, where the basic immobilized amine sorbent comprises a polyamine bound to an inorganic support via a linker, such that contacting the wastewater causes at a least a portion of the organic contaminate to bind to the basic immobilized amine sorbent.
FILED	Wednesday, October 31, 2018
APPL NO	16/176804
ART UNIT	1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) B01J 20/262 (20130101) B01J 20/2803 (20130101) B01J 20/28011 (20130101) B01J 20/28016 (20130101) B01J 20/28026 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/285 (20130101) Original (OR) Class C02F 2101/36 (20130101) C02F 2101/306 (20130101) C02F 2101/308 (20130101) C02F 2101/345 (20130101)
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10836678 — High-performance concrete mix for precast wythes

US 10836678	Hun et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee); University of Tennessee at Chattanooga (Chattanooga, Tennessee)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee); UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
INVENTOR(S)	Diana E. Hun (Lenoir City, Tennessee); Catherine H. Mattus (Oak Ridge, Tennessee); Mbakisya Onyango (Chattanooga, Tennessee); Joseph Owino (Hixson, Tennessee); Alex Brent Rollins (Dalton, Georgia)
ABSTRACT	A lightweight concrete composition includes the concrete components, per yd³of concrete: Type III Portland cement (lb/yd³) 200-900; metakaolin (lb/yd³) 100-520; calcium sulfoaluminate cement (CSA) (lb/yd³) 40-840; 3/8″ lightweight expanded slate aggregate (lb/yd³) 70-550; lightweight fine expanded slate aggregate (lb/yd³) 300-550; expanded glass fine aggregate (0.5-1 mm) 35-90 (lb/yd³); expanded glass fine aggregate (1-2 mm) 35-90 (lb/yd³); water (lb/yd³) 300-350; CSA cement set retarder 0.015 to 0.06 oz per lb of CSA cement; high-range water-reducing admixture 120-1000 (fl. oz/yd³); hydration controlling admixture 0-80 (fl. oz/yd³); reinforcing non-metallic lightweight fibers <1.5″ in length 0-8 (lb/yd³); wherein the concrete has a flexural strength of at least 600 psi at 12 hours, a density of 95 to 110 lb/ft³, and a compressive strength at 28 days of at least 7,000 psi. A lightweight concrete wythe and method of making a lightweight concrete wythe are also disclosed.
FILED	Friday, April 12, 2019
APPL NO	16/383058
ART UNIT	1783 — Miscellaneous Articles, Stock Material
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/42 (20130101) C04B 14/106 (20130101) C04B 18/027 (20130101) C04B 28/065 (20130101) Original (OR) Class C04B 2103/22 (20130101) C04B 2103/302 (20130101) C04B 2111/40 (20130101) C04B 2201/20 (20130101) C04B 2201/50 (20130101) Structural Elements; Building Materials E04C 2/044 (20130101)
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10836774 — Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds

US 10836774	Lindsey et al.
FUNDED BY	Department of Energy (DOE)
APPLICANT(S)	North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)	North Carolina State University (Raleigh, North Carolina)
INVENTOR(S)	Jonathan S. Lindsey (Raleigh, North Carolina); Shaofei Zhang (Raleigh, North Carolina)
ABSTRACT	Described herein are bacteriochlorins comprising an annulated isocyclic ring such as a compound Formula I: or a metal conjugate thereof, wherein: R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, and Z are each as defined herein. Also described are methods and intermediates for the synthesis of bacteriochlorins comprising an annulated isocyclic ring, and methods of using such bacteriochlorins for, among other things, diagnostic and therapeutic purposes such as, e.g., luminescent compounds in flow cytometry, and/or as active agents in photodynamic therapy (PDT).
FILED	Monday, November 27, 2017
APPL NO	16/464728
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/409 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/22 (20130101) Original (OR) Class
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10836855 — Method to produce colorless, high porosity, transparent polymer aerogels

US 10836855	Chintapalli et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	PALO ALTO RESEARCH CENTER INCORPORATED (Palo Alto, California); XEROX CORPORATION (Norwalk, Connecticut)
ASSIGNEE(S)	PALO ALTO RESEARCH CENTER INCORPORATED (Palo Alto, California); XEROX CORPORATION (Norwalk, Connecticut)
INVENTOR(S)	Mahati Chintapalli (Mountain View, California); Barkev Keoshkerian (Thornhill, Canada); Alec Ho (Pasadena, California); Gabriel Iftime (Dublin, California); Quentin Van Overmeere (Mountain View, California); Eli Bulger (Nottawa, Canada)
ABSTRACT	A method to produce a polymer gel includes dissolving precursors in a solvent to form a precursor solution, the precursors including polymer precursors, a stable free radical, one or more initiating radicals, and one or more stable free radical control agents, and heating the precursor solution to a temperature of polymerization to produce a cross-linked gel. A dried polymer aerogel has a Brunauer-Emmett Teller (BET) surface area over 100 m2/g, porosity of greater than 10%, visible transparency greater than 20%, color rendering index of over 20%, and average pore size of less than 100 nm.
FILED	Thursday, July 26, 2018
APPL NO	16/046692
ART UNIT	1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0065 (20130101) B01J 13/0091 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 293/005 (20130101) Original (OR) Class C08F 2438/02 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101)
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10837025 — Control of cellulose biosynthesis by overexpression of a transcription factor

US 10837025	Han et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S)	Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S)	Kyung-Hwan Han (Okemos, Michigan); Jae-Heung Ko (Suwon, South Korea); Won-Chan Kim (Okemos, Michigan); Joo-Yeol Kim (Lansing, Michigan)
ABSTRACT	The invention relates to nucleic acids, proteins and methods for modulating the cellulose content of plants.
FILED	Tuesday, April 04, 2017
APPL NO	15/478661
ART UNIT	1663 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8246 (20130101) Original (OR) Class
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10837038 — Adjusting the pH of a pretreatment solution using carbon dioxide useful for integrating saccharification and fermentation

US 10837038	Sun et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Jian Sun (Albany, California); Jian Shi (Albany, California); Blake A. Simmons (San Francisco, California); Seema Singh (Mountain House, California)
ABSTRACT	The present invention provides for a method of fermenting or saccharifying a biomass comprising: (a) (i) contacting a biomass comprising a polysaccharide, and an ionic liquid (IL) to form a first solution, or (ii) providing the first solution comprising the biomass and the IL, (b) contacting the first solution and carbon dioxide such that the first solution results in a lower pH, (c) introducing (i) an enzyme capable of enzymatically to breakdown at least one bond in the polysaccharide or a breakdown product of the polysaccharide, and/or (ii) a microorganism that capable of producing the enzyme and/or fermenting the polysaccharide or a breakdown product of the polysaccharide, such that the polysaccharide is at least partially broken down and the first solution is transformed into a second solution.
FILED	Wednesday, December 23, 2015
APPL NO	15/539614
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Polysaccharides; Derivatives Thereof C08B 1/003 (20130101) Derivatives of Natural Macromolecular Compounds C08H 8/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) C12P 7/065 (20130101) C12P 7/649 (20130101) C12P 19/02 (20130101) C12P 19/14 (20130101) Original (OR) Class C12P 2201/00 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/13 (20130101) Y02E 50/16 (20130101) Y02E 50/17 (20130101)
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10837139 — Durable polymer-aerogel based superhydrophobic coatings: a composite material

US 10837139	Kissel et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	David J. Kissel (Andover, Massachusetts); Charles Jeffrey Brinker (Albuquerque, New Mexico)
ASSIGNEE(S)	UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico)
INVENTOR(S)	David J. Kissel (Andover, Massachusetts); Charles Jeffrey Brinker (Albuquerque, New Mexico)
ABSTRACT	Provided are polymer-aerogel composite coatings, devices and articles including polymer-aerogel composite coatings, and methods for preparing the polymer-aerogel composite. The exemplary article can include a surface, wherein the surface includes at least one region and a polymer-aerogel composite coating disposed over the at least one region, wherein the polymer-aerogel composite coating has a water contact angle of at least about 140° and a contact angle hysteresis of less than about 1°. The polymer-aerogel composite coating can include a polymer and an ultra high water content catalyzed polysilicate aerogel, the polysilicate aerogel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.
FILED	Monday, December 28, 2015
APPL NO	14/981400
ART UNIT	1789 — Miscellaneous Articles, Stock Material
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 55/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) C08K 9/06 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/006 (20130101) C09D 5/14 (20130101) C09D 5/165 (20130101) C09D 5/1681 (20130101) C09D 7/62 (20180101) C09D 133/12 (20130101) Wall, Floor, or Like Covering Materials, e.g Linoleum, Oilcloth, Artificial Leather, Roofing Felt, Consisting of a Fibrous Web Coated With a Layer of Macromolecular Material; Flexible Sheet Material Not Otherwise Provided for D06N 3/0043 (20130101) Original (OR) Class D06N 3/0063 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2401/10 (20130101) D10B 2401/13 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24999 (20150401) Y10T 428/249953 (20150401) Y10T 428/249972 (20150401) Y10T 428/249991 (20150401) Y10T 442/20 (20150401)
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10837624 — Adjustable-beam luminaires

US 10837624	Gladden et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Glint Photonics, Inc. (Burlingame, California)
ASSIGNEE(S)	Glint Photonics, Inc. (Burlingame, California)
INVENTOR(S)	Christopher Gladden (San Mateo, California); Andrew Kim (San Jose, California); Peter Kozodoy (Palo Alto, California); Barbara Kruse (San Francisco, California)
ABSTRACT	A luminaire for providing configurable static lighting or dynamically-adjustable lighting. The luminaire uses an array of focusing elements that act on light provided via a corresponding array of sources or via an edge-lit lightguide. Designs are provided for adjusting the number of distinct beams produced by the luminaire, as well as the angular width, angular profile, and pointing angle of the beams. Designs are also provided for systems utilizing the adjustable luminaires in various applications.
FILED	Thursday, March 14, 2019
APPL NO	16/353647
ART UNIT	2875 — Optics
CURRENT CPC	Non-electric Light Sources Using Luminescence; Light Sources Using Electrochemiluminescence; Light Sources Using Charges of Combustible Material; Light Sources Using Semiconductor Devices as Light-generating Elements; Light Sources Not Otherwise Provided for F21K 9/61 (20160801) Functional Features or Details of Lighting Devices or Systems Thereof; Structural Combinations of Lighting Devices With Other Articles, Not Otherwise Provided for F21V 5/007 (20130101) F21V 7/0008 (20130101) F21V 14/06 (20130101) Original (OR) Class F21V 17/02 (20130101) Indexing Scheme Associated With Subclasses F21K, F21L, F21S and F21V, Relating to the Form or the Kind of the Light Sources or of the Colour of the Light Emitted F21Y 2105/00 (20130101) F21Y 2115/10 (20160801) Optical Elements, Systems, or Apparatus G02B 3/0006 (20130101) G02B 6/005 (20130101) G02B 6/0036 (20130101) G02B 6/0055 (20130101) G02B 19/0028 (20130101) G02B 19/0066 (20130101) G02B 26/08 (20130101) G02B 26/0875 (20130101)
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10837811 — Systems, methods and computer program products for self-tuning sensor data processing

US 10837811	Draelos et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Timothy J. Draelos (Albuquerque, New Mexico); Aleksandra Faust (Palo Alto, California); Hunter A. Knox (Albuquerque, New Mexico); Matthew G. Peterson (Albuquerque, New Mexico)
ABSTRACT	Systems and methods are disclosed that include tools that utilize Dynamic Detector Tuning (DDT) software that identifies near-optimal parameter settings for each sensor using a neuro-dynamic programming (reinforcement learning) paradigm. DDT adapts parameter values to the current state of the environment by leveraging cooperation within a neighborhood of sensors. The key metric that guides the dynamic tuning is consistency of each sensor with its nearest neighbors: parameters are automatically adjusted on a per station basis to be more or less sensitive to produce consistent agreement of detections in its neighborhood. The DDT algorithm adapts in near real-time to changing conditions in an attempt to automatically self-tune a signal detector to identify (detect) only signals from events of interest. The disclosed systems and methods reduce the number of missed legitimate detections and the number of false detections, resulting in improved event detection.
FILED	Thursday, November 30, 2017
APPL NO	15/828188
ART UNIT	2865 — Printing/Measuring and Testing
CURRENT CPC	Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 18/006 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/046 (20130101) G06N 20/00 (20190101)
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10837910 — Shaped-excitation fluorescence (SEF) microscopy

US 10837910	Zamkov
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	Bowling Green State University (Bowling Green, Ohio)
ASSIGNEE(S)	Bowling Green State University (Bowling Green, Ohio)
INVENTOR(S)	Mikhail Zamkov (Bowling Green, Ohio)
ABSTRACT	A method and apparatus for detecting more than one fluorophore in a sample. A broad spectrum excitation light is passed through a shaping filter before illuminating the target sample with more than one fluorophore to be detected, where the optical density of the shaping filter changes based on the wavelength of the broad-spectrum excitation light passing through it.
FILED	Thursday, January 10, 2019
APPL NO	16/245241
ART UNIT	2884 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/648 (20130101) G01N 21/6428 (20130101) G01N 21/6447 (20130101) G01N 21/6458 (20130101) Original (OR) Class G01N 2021/6417 (20130101) G01N 2021/6439 (20130101) G01N 2021/6441 (20130101) G01N 2021/6471 (20130101) Optical Elements, Systems, or Apparatus G02B 21/16 (20130101)
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10837912 — Systems and methods for control of polymer reactions and processing using automatic continuous online monitoring

US 10837912	Reed et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. (New Orleans, Louisiana); THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana)
ASSIGNEE(S)	ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. (New Orleans, Louisiana); THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana)
INVENTOR(S)	Wayne Frederick Reed (New Orleans, Louisiana); Michael Felix Drenski (New Orleans, Louisiana)
ABSTRACT	Manual and automatic methods and devices using a ACOMP system for active control of polymerization reaction processes. An ideal desired trajectory of one or more reaction and polymer characteristics can be established to produce a desired final polymer product with specified characteristics from a polymerization reaction process. A current reaction trajectory of a polymerization reaction process can be driven to an ideal or desired reaction trajectory. In a manual embodiment an operator can use ACOMP data to adjust process variables in order to drive the current reaction trajectory toward the ideal or desired reaction trajectory. In an automated mode a control program can use ACOMP data to make adjustments to process variables to drive the polymerization reaction process toward the desired trajectory as closely as possible either empirically or by solving the governing equations for the polymerization reaction process.
FILED	Wednesday, September 30, 2015
APPL NO	15/515119
ART UNIT	1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/1809 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/02 (20130101) G01N 15/06 (20130101) G01N 21/75 (20130101) Original (OR) Class G01N 2015/0693 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/04 (20130101)
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10837989 — System and method to characterize and identify operating modes of electric loads

US 10837989	Yang et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	EATON INTELLIGENT POWER LIMITED (Dublin, Ireland)
ASSIGNEE(S)	EATON INTELLIGENT POWER LIMITED (Dublin, Ireland)
INVENTOR(S)	Yi Yang (Milwaukee, Wisconsin); Mayura Arun Madane (Maharashtra, India); Prachi Suresh Zambare (Maharashtra, India)
ABSTRACT	A system characterizes and identifies one of a plurality of different operating modes of a number of electric loads. The system includes a processor; a voltage sensor providing a voltage signal for one of the electric loads to the processor; a current sensor providing a current signal for the one electric load to the processor; and a routine executed by the processor and structured to characterize the different operating modes using steady state and voltage-current trajectory features determined from the voltage and current signals, and to identify a particular one of the different operating modes based on a plurality of operating mode membership functions of the steady state and voltage-current trajectory features.
FILED	Friday, December 27, 2019
APPL NO	16/728768
ART UNIT	2864 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 19/16528 (20130101) Original (OR) Class Electric Digital Data Processing G06F 1/28 (20130101)
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10838149 — Dual-core fiber amplifier for separation of thermal and nonlinear effects

US 10838149	Drachenberg et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Derrek R. Drachenberg (Livermore, California); Paul H. Pax (Livermore, California)
ABSTRACT	A dual-core waveguide architecture provides two evanescently coupled waveguides where a first waveguide is doped with an active gain species to produce optical power and a second waveguide that runs parallel to the first waveguide is configured to collect the power produced by the first waveguide. Power is harvested from the second waveguide.
FILED	Tuesday, March 05, 2019
APPL NO	16/292601
ART UNIT	2874 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/10 (20130101) G02B 6/262 (20130101) G02B 6/02042 (20130101) G02B 6/02057 (20130101) G02B 6/29332 (20130101) Original (OR) Class Amplifiers H03F 3/21 (20130101)
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10838727 — Device and method for cache utilization aware data compression

US 10838727	Das et al.
FUNDED BY	Department of Energy (DOE) Exascale Computing Project (ECP) PathForward Project (PATHFORWARD) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)	ADVANCED MICRO DEVICES, INC. (Santa Clara, California)
INVENTOR(S)	Shomit N. Das (Austin, Texas); Kishore Punniyamurthy (Austin, Texas); Matthew Tomei (Champaign, Illinois); Bradford M. Beckmann (Bellevue, Washington)
ABSTRACT	A processing device is provided which includes memory and at least one processor. The memory includes main memory and cache memory in communication with the main memory via a link. The at least one processor is configured to receive a request for a cache line and read the cache line from main memory. The at least one processor is also configured to compress the cache line according to a compression algorithm and, when the compressed cache line includes at least one byte predicted not to be accessed, drop the at least one byte from the compressed cache line based on whether the compression algorithm is determined to successfully compress the cache line according to a compression parameter.
FILED	Friday, December 14, 2018
APPL NO	16/220508
ART UNIT	2138 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 9/3816 (20130101) Original (OR) Class G06F 12/0808 (20130101) G06F 12/0868 (20130101) G06F 12/0871 (20130101)
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10838864 — Prioritizing local and remote memory access in a non-uniform memory access architecture

US 10838864	Boyer et al.
FUNDED BY	Department of Energy (DOE) Exascale Computing Project (ECP) PathForward Project (PATHFORWARD) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	ADVANCED MICRO DEVICES, INC. (Santa Clara, California)
ASSIGNEE(S)	ADVANCED MICRO DEVICES, INC. (Santa Clara, California)
INVENTOR(S)	Michael W. Boyer (Bellevue, Washington); Onur Kayiran (Santa Clara, California); Yasuko Eckert (Bellevue, Washington); Steven Raasch (Boxborough, Massachusetts); Muhammad Shoaib Bin Altaf (Austin, Texas)
ABSTRACT	A miss in a cache by a thread in a wavefront is detected. The wavefront includes a plurality of threads that are executing a memory access request concurrently on a corresponding plurality of processor cores. A priority is assigned to the thread based on whether the memory access request is addressed to a local memory or a remote memory. The memory access request for the thread is performed based on the priority. In some cases, the cache is selectively bypassed depending on whether the memory access request is addressed to the local or remote memory. A cache block is requested in response to the miss. The cache block is biased towards a least recently used position in response to requesting the cache block from the local memory and towards a most recently used position in response to requesting the cache block from the remote memory.
FILED	Wednesday, May 30, 2018
APPL NO	15/992885
ART UNIT	2138 — Memory Access and Control
CURRENT CPC	Electric Digital Data Processing G06F 3/1263 (20130101) G06F 9/5038 (20130101) G06F 12/126 (20130101) G06F 12/0815 (20130101) Original (OR) Class G06F 12/0888 (20130101) G06F 12/1045 (20130101) G06F 13/18 (20130101) G06F 13/30 (20130101) G06F 2212/657 (20130101) G06F 2212/684 (20130101) G06F 2212/1008 (20130101)
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10839195 — Machine learning technique to identify grains in polycrystalline materials samples

US 10839195	Sankaranarayanan et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S)	Subramanian Sankaranarayanan (Naperville, Illinois); Mathew J. Cherukara (Lemont, Illinois); Badri Narayanan (Lemont, Illinois); Henry Chan (Lemont, Illinois)
ABSTRACT	A method of identifying grains in polycrystalline materials, the method including (a) identifying local crystal structure of the polycrystalline material based on neighbor coordination or pattern recognition machine learning, the local crystal structure including grains and grain boundaries, (b) pre-processing the grains and the grain boundaries using image processing techniques, (c) conducting grain identification using unsupervised machine learning; and (d) refining a resolution of the grain boundaries.
FILED	Tuesday, August 08, 2017
APPL NO	15/672168
ART UNIT	2126 — AI & Simulation/Modeling
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00147 (20130101) Original (OR) Class G06K 9/6276 (20130101) Computer Systems Based on Specific Computational Models G06N 5/003 (20130101) G06N 20/00 (20190101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/30 (20190201) G16C 20/70 (20190201) G16C 60/00 (20190201)
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10839974 — High optical transparent two-dimensional electronic conducting system and process for generating same

US 10839974	Alam et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
ASSIGNEE(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
INVENTOR(S)	Muhammad Ashraful Alam (West Lafayette, Indiana); Ruiyi Chen (Hangzhou, China PRC); Suprem R. Das (West Lafayette, Indiana); David B. Janes (West Lafayette, Indiana); Changwook Jeong (West Lafayette, Indiana); Mark Lundstrom (Lafayette, Indiana)
ABSTRACT	Hybrid transparent conducting materials are disclosed with combine a polycrystalline film and conductive nanostructures, in which the polycrystalline film is “percolation doped” with the conductive nanostructures. The polycrystalline film preferably is a single atomic layer thickness of polycrystalline graphene, and conductive nanostructures preferably are silver nanowires.
FILED	Tuesday, October 01, 2019
APPL NO	16/589393
ART UNIT	1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/13439 (20130101) G02F 2202/36 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) Original (OR) Class H01B 1/04 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/413 (20130101) H01L 29/1606 (20130101) H01L 31/028 (20130101) H01L 31/1864 (20130101) H01L 31/1884 (20130101) H01L 31/022466 (20130101) H01L 31/022491 (20130101) H01L 51/442 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/547 (20130101) Y02E 10/549 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2438 (20150115)
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10840531 — Two-electron redox active molecules with high capacity and energy density for energy storage applications

US 10840531	Huang et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UChicago Argonne, LLC (Chicago, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S)	Jinhua Huang (Willowbrook, Illinois); Lu Zhang (Lisle, Illinois); Anthony K. Burrell (Naperville, Illinois); Zhengcheng Zhang (Naperville, Illinois)
ABSTRACT	A non-aqueous redox flow battery includes a catholyte including a compound of formula (I): wherein E¹and E²are independently O, S, S═O, S(═O)₂, Se, NR¹¹, or PR¹¹; The compounds of the present technology are capable of undergoing a reversible two-electron transfer process, thus leading to high efficiency of molecular design and an increase in the overall energy density.
FILED	Monday, August 31, 2015
APPL NO	14/841012
ART UNIT	1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Heterocyclic Compounds C07D 241/46 (20130101) C07D 279/22 (20130101) C07D 339/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/528 (20130101)
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10840532 — Flow battery with electrolyte rebalancing system

US 10840532	Chen et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Qing Chen (Cambridge, Massachusetts); Roy G. Gordon (Cambridge, Massachusetts); Michael J. Aziz (Concord, Massachusetts)
ABSTRACT	The present invention relates to flow battery systems including a flow battery and an electrolyte rebalancing system. In accordance with certain embodiments, the electrolytes used in the systems of the present invention are aqueous, and in one embodiment, bromine species are used as redox-active species.
FILED	Monday, January 29, 2018
APPL NO	15/882032
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/20 (20130101) H01M 8/188 (20130101) Original (OR) Class H01M 8/04007 (20130101) H01M 8/04276 (20130101) H01M 2300/0005 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/528 (20130101)
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10840536 — Stretchable electronic systems with containment chambers

US 10840536	Rogers et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS) Office of The Director (OD) Office of International Science and Engineering (OISE)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois); NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois); Northwestern University (Evanston, Illinois)
INVENTOR(S)	John A. Rogers (Champaign, Illinois); Sheng Xu (Urbana, Illinois); Jonathan A. Fan (Columbus, Ohio); Yonggang Huang (Glencoe, Illinois); Yihui Zhang (Evanston, Illinois); Lin Jia (Boston, Massachusetts)
ABSTRACT	The present invention provides electronic systems, including device arrays, comprising functional device(s) and/or device component(s) at least partially enclosed via one or more containment chambers, such that the device(s) and/or device component(s) are at least partially, and optionally entirely, immersed in a containment fluid. Useful containment fluids for use in containment chambers of electronic devices of the invention include lubricants, electrolytes and/or electronically resistive fluids. In some embodiments, for example, electronic systems of the invention comprise one or more electronic devices and/or device components provided in free-standing and/or tethered configurations that decouple forces originating upon deformation, stretching or compression of a supporting substrate from the free standing or tethered device or device component.
FILED	Wednesday, February 05, 2014
APPL NO	14/766301
ART UNIT	2848 — Electrical Circuits and Systems
CURRENT CPC	Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/26 (20130101) H01G 11/78 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/54 (20130101) H01L 23/18 (20130101) H01L 23/22 (20130101) H01L 2224/16225 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/12032 (20130101) H01L 2924/12032 (20130101) H01L 2924/12041 (20130101) H01L 2924/12041 (20130101) H01L 2924/12042 (20130101) H01L 2924/12042 (20130101) H01L 2924/12043 (20130101) H01L 2924/12043 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/0202 (20130101) H01M 2/204 (20130101) H01M 2/206 (20130101) H01M 2/0237 (20130101) H01M 8/02 (20130101) H01M 10/02 (20130101) Original (OR) Class H01M 10/0525 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/189 (20130101) H05K 1/0283 (20130101) H05K 2201/0133 (20130101) H05K 2201/09263 (20130101) H05K 2201/10037 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49126 (20150115)
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10840546 — Vitreous solid electrolyte sheets of Li ion conducting sulfur-based glass and associated structures, cells and methods

US 10840546	Visco et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	PolyPlus Battery Company (Berkeley, California)
ASSIGNEE(S)	PolyPlus Battery Company (Berkeley, California)
INVENTOR(S)	Steven J. Visco (Berkeley, California); Yevgeniy S. Nimon (Danville, California); Lutgard C. De Jonghe (Lafayette, California); Bruce D. Katz (Moraga, California); Vitaliy Nimon (San Francisco, California)
ABSTRACT	A lithium ion-conductive solid electrolyte including a freestanding inorganic vitreous sheet of sulfide-based lithium ion conducting glass is capable of high performance in a lithium metal battery by providing a high degree of lithium ion conductivity while being highly resistant to the initiation and/or propagation of lithium dendrites. Such an electrolyte is also itself manufacturable, and readily adaptable for battery cell and cell component manufacture, in a cost-effective, scalable manner.
FILED	Friday, November 02, 2018
APPL NO	16/179803
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/1613 (20130101) H01M 2/1646 (20130101) H01M 10/052 (20130101) H01M 10/056 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) H01M 2300/0071 (20130101)
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10840547 — Encapsulated sulfide glass solid electrolytes and solid-state laminate electrode assemblies

US 10840547	Visco et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	PolyPlus Battery Company (Berkeley, California)
ASSIGNEE(S)	POLYPLUS BATTERY COMPANY (Berkeley, California)
INVENTOR(S)	Steven J. Visco (Berkeley, California); Vitaliy Nimon (San Francisco, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California)
ABSTRACT	Nanofilm-encapsulated sulfide glass solid electrolyte structures and methods for making the encapsulated glass structures involve a lithium ion conducting sulfide glass sheet encapsulated on its opposing major surfaces by a continuous and conformal nanofilm made by atomic layer deposition (ALD). During manufacture, the reactive surfaces of the sulfide glass sheet are protected from deleterious reaction with ambient moisture, and the nanofilm can be configured to provide additional performance advantages, including enhanced mechanical strength and improved chemical resistance.
FILED	Wednesday, June 27, 2018
APPL NO	16/341872
ART UNIT	1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/40 (20130101) C23C 16/345 (20130101) C23C 16/45536 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/0421 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) H01M 2300/0071 (20130101) H01M 2300/0094 (20130101)
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10840552 — Additives for high voltage lithium ion batteries

US 10840552	Peebles et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)	UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S)	Cameron Peebles (Oak Park, Illinois); Ilya A. Shkrob (Chicago, Illinois); Chen Liao (Westmont, Illinois); Daniel Abraham (Bolingbrook, Illinois); Hakim Iddir (Hoffman Estates, Illinois); Juan Garcia (Naperville, Illinois)
ABSTRACT	This invention relates to a method for preparing an electrochemical cell comprising the sequential steps of preparing a solution of a lithium salt in an non-aqueous solvent containing an additive compound, and maintaining the solution at a temperature in the range of about 20 to about 30° C. for about 5 to 10 days to form an aged electrolyte; assembling an electrochemical cell from an anode, a cathode, and the aged electrolyte; and electrochemically subjecting the electrochemical cell to formation cycling. The additive compound comprises one or more compounds selected from the group consisting of: (R₃SiO)₃B, (R₃SiO)₃XY, (R₃SiO)₃P, (R′O)₃PO, (R₃Si)₃X′, R₃SiOS(O)₂R′; (R₃Si)OC(═O)R′; wherein each R and R′ independently is a hydrocarbyl group; X is P or B; Y is O or S; X is Ti or Al. Electrochemical cells and batteries also are described.
FILED	Friday, March 09, 2018
APPL NO	15/916723
ART UNIT	1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/058 (20130101) H01M 10/0525 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2220/20 (20130101) H01M 2300/0037 (20130101)
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10840668 — Laser gain media fabricated via direct ink writing (DIW) and ceramic processing

US 10840668	Payne et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Stephen A. Payne (Castro Valley, California); Nerine J. Cherepy (Piedmont, California); Eric B. Duoss (Dublin, California); Ivy Krystal Jones (Chicago, Illinois); Zachary M. Seeley (Livermore, California); Cheng Zhu (Livermore, California)
ABSTRACT	A transparent ceramic optic includes: a lasing region comprising at least one lasing species dopant; and a transparent region transparent to light generated by the lasing species. At least the transparent region is doped with at least one other dopant species such that the lasing region and the transparent region are characterized by a difference in refractive index between the two regions in an amount of about 1.0×10⁻⁴or less. Inventive formulations of inks suitable for fabricating transparent ceramic optics having desirable compositional characteristics such as concentration gradients in desired spatial arrangements, e.g. using additive manufacturing techniques such as direct ink writing and/or extrusion freeform fabrication are also disclosed, along with suitable techniques for forming the transparent ceramic optics from such inks.
FILED	Friday, June 16, 2017
APPL NO	16/306865
ART UNIT	1764 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/113 (20130101) H01S 3/0617 (20130101) Original (OR) Class H01S 3/0912 (20130101) H01S 3/0941 (20130101) H01S 3/1643 (20130101)
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10841277 — One step removed shadow network

US 10841277	Park et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT-BATTELLE, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	Brent K. Park (Oak Ridge, Tennessee); Stacy J. Prowell (Oak Ridge, Tennessee); Richard A. Raines (Oak Ridge, Tennessee); Joseph P. Trien (Oak Ridge, Tennessee)
ABSTRACT	A system and method includes an operational network that communicates with an external network by opening a first transmission protocol socket. A data diode coupled to the operational network and a gateway enables the one-way transfer of all information received from the external network and transmitted by the operational network to the gateway such that no information travels from the gateway to the operational network or the external network. The gateway opens a second transmission protocol socket by mapping a sequence number to an acknowledgement number and increasing that mapped acknowledgement number by a value of one. A transmitter then transmits the acknowledgment to a remote network or a gateway.
FILED	Monday, August 13, 2018
APPL NO	16/102377
ART UNIT	2432 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 12/66 (20130101) H04L 41/145 (20130101) H04L 47/34 (20130101) H04L 49/552 (20130101) H04L 63/02 (20130101) Original (OR) Class H04L 63/1433 (20130101) H04L 69/16 (20130101) H04L 69/18 (20130101)
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10841322 — Decision system and method for separating faults from attacks

US 10841322	Giani et al.
FUNDED BY	Department of Energy (DOE) Office of Electricity (DOE-OE)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	GENERAL ELECTRIC COMPANY (Schenectady, New York)
INVENTOR(S)	Annarita Giani (Niskayuna, New York); Masoud Abbaszadeh (Clifton Park, New York); Lalit Keshav Mestha (Month Colonie, New York)
ABSTRACT	According to some embodiments, a plurality of monitoring nodes may each generate a series of current monitoring node values over time that represent a current operation of the industrial asset. A node classification computer may determine, for each monitoring node, a classification result indicating whether each monitoring node is in a normal or abnormal state. A disambiguation engine may receive the classification results from the node classification computer and associate a Hidden Markov Model (“HMM”) with each monitoring node. For each node in an abnormal state, the disambiguation engine may execute the HMM associated with that monitoring node to determine a disambiguation result indicating if the abnormal state is a result of an attack or a fault and output a current status of each monitoring node based on the associated classification result and the disambiguation result.
FILED	Friday, April 20, 2018
APPL NO	15/958285
ART UNIT	2432 — Cryptography and Security
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/048 (20130101) Electric Digital Data Processing G06F 11/006 (20130101) G06F 21/50 (20130101) G06F 2201/86 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6267 (20130101) G06K 9/6297 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/14 (20130101) H04L 63/1425 (20130101) Original (OR) Class
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National Science Foundation (NSF)

10835111 — Three-dimensional imaging using swept, confocally aligned planar excitation with an image relay

US 10835111	Hillman
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Elizabeth Marjorie Clare Hillman (New York, New York)
ABSTRACT	The disclosed subject matter includes devices and systems for extending the imaging capability of swept, confocally aligned planar excitation (SCAPE) microscopes to in vivo applications. In embodiments, the SCAPE microscope can be implemented as an endoscopic or laparoscopic inspection instrument.
FILED	Monday, July 10, 2017
APPL NO	16/314752
ART UNIT	2482 — Recording and Compression
CURRENT CPC	Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/07 (20130101) A61B 1/00172 (20130101) A61B 1/00174 (20130101) Original (OR) Class A61B 1/00197 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0087 (20130101) G02B 21/006 (20130101) G02B 21/0028 (20130101) G02B 21/0048 (20130101) G02B 21/0076 (20130101) Pictorial Communication, e.g Television H04N 5/2251 (20130101) H04N 2005/2255 (20130101)
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10835549 — Polyplexes

US 10835549	Duvall et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) Non-Profit Organization (NPO) American Heart Association (AHA) National Science Foundation (NSF)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee); The United States as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee); The United States as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Craig Duvall (Nashville, Tennessee); Brian Connor Evans (Bartlett, Tennessee); Colleen Brophy (Nashville, Tennessee); Kyle Hocking (Alpharetta, Georgia)
ABSTRACT	The present disclosure relates to compounds comprising (i) an active agent, wherein the active agent includes a charge at a predetermined pH, (ii) a polymer, wherein the polymer includes an opposite charge than the active agent at the predetermined pH; and (iii) a polyplex comprising the peptide and the polymer electrostatically bond together at the predetermined pH. In some embodiments, the active agent is a peptide, such as a peptide comprising MAPKAP kinase II inhibitory peptide, and in some embodiments the peptide includes a cell-penetrating peptide. In further embodiments, the disclosure provides methods for treating a disease or condition by administering a composition according to the present disclosure to a subject in need thereof.
FILED	Friday, April 11, 2014
APPL NO	14/784017
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/711 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 38/005 (20130101) A61K 38/55 (20130101) A61K 38/55 (20130101) A61K 47/32 (20130101) A61K 47/58 (20170801) A61K 47/6927 (20170801) A61K 2300/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 2300/252 (20130101)
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10835609 — Hydrogels for delivery of therapeutic compounds

US 10835609	Knipe et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	Board of Regents, the University of Texas System (Austin, Texas)
ASSIGNEE(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S)	Jennifer M. Knipe (Austin, Texas); Laura E. Strong (Austin, Texas); Nicholas A. Peppas (Austin, Texas)
ABSTRACT	In some aspects, methacrylate co-polymers crosslinked with an enzymatically cleavable peptide linker are provided and may be used for the oral delivery of a therapeutic. The peptide linker may be cleavable by an enzyme in the small intestine and may allow for the delivery of a therapeutic protein or nucleic acid to the small intestine. Also provided are methods of using the polymers for the treatment of a disease.
FILED	Tuesday, February 27, 2018
APPL NO	15/906881
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/1635 (20130101) A61K 9/5026 (20130101) A61K 9/5138 (20130101) A61K 38/06 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/16 (20130101) A61K 38/28 (20130101) A61K 47/32 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 33/02 (20130101) C08L 39/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2320/32 (20130101)
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10835955 — Polyhedral metal nanocages with well-defined facets and ultrathin walls and methods of making and uses thereof

US 10835955	Xia et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)	Georgia Tech Research Corporation (Atlanta, Georgia)
INVENTOR(S)	Younan Xia (Atlanta, Georgia); Dong Qin (Atlanta, Georgia); Xue Wang (Jiaozhou, China PRC); Sang-Il Choi (Daegu, South Korea); Sujin Lee (Atlanta, Georgia); Lei Zhang (Hengshui, China PRC); Xiaojun Sun (Prospect Heights, Illinois); Junki Kim (Goyang-si, South Korea); Ming Zhao (Atlanta, Georgia)
ABSTRACT	A variety of polyhedral nanocages are provided having a hollow interior, ultrathin walls, and well-defined facets of metal atoms. The nanocages can include a variety of precious metals such as Pt, Au, Ru, Rh, or Ir. The metal atoms can take a face-centered cubic structure with {111} facets on the surface. The walls can be thin, sometimes less than 1 nm in thickness or only a few atomic layers in thickness. The nanocages can provide for efficient uses of valuable precious metals, among other things, in catalysis. For example, catalysts are provided exhibiting high mass activities in oxygen reduction reactions. Methods of making and methods of using the nanocages and catalysts are also provided.
FILED	Thursday, June 09, 2016
APPL NO	15/580377
ART UNIT	1784 — Miscellaneous Articles, Stock Material
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0018 (20130101) Original (OR) Class B22F 1/025 (20130101) B22F 1/025 (20130101) B22F 9/16 (20130101) B22F 9/24 (20130101) B22F 9/24 (20130101) B22F 2001/0029 (20130101) B22F 2001/0037 (20130101) B22F 2003/244 (20130101) B22F 2301/25 (20130101) B22F 2304/054 (20130101) B22F 2998/10 (20130101) B22F 2998/10 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Alloys C22C 5/00 (20130101) C22C 27/00 (20130101)
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10836638 — Metal phosphide nanomaterials prepared from single source metal amides

US 10836638	Kemp et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	STC.UNM (Albuquerque, New Mexico); SANDIA CORPORATION (Albuquerque, New Mexico)
ASSIGNEE(S)	UNM Rainforest Innovations (Albuquerque, New Mexico)
INVENTOR(S)	Richard Alan Kemp (Albuquerque, New Mexico); Diane Dickie (Albuquerque, New Mexico); Bernadette A. Hernandez-Sanchez (Albuquerque, New Mexico); Timothy N. Lambert (Albuquerque, New Mexico)
ABSTRACT	The present invention provides a novel solution or route for metal phosphide (MP_x) nanomaterials from the thermal decomposition of metal bis[bis(diisopropylphosphino)amide], M[N(PPri₂)₂]₂, and/or single-source precursors. Synthetic routes to MP_xnanomaterials may be used in energy applications including batteries, semiconductors, magnets, catalyst, lasers, inks, electrocatalysts and photodiodes.
FILED	Friday, April 08, 2016
APPL NO	15/565670
ART UNIT	1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 25/08 (20130101) Original (OR) Class C01B 25/082 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2004/04 (20130101) C01P 2004/64 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/5045 (20130101) Alloys C22C 1/00 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/81 (20130101) Y10S 977/773 (20130101) Y10S 977/825 (20130101) Y10S 977/896 (20130101)
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10836865 — Ionic polyamide and polyamide-imide materials and methods of use

US 10836865	Bara et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama)
ASSIGNEE(S)	The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama)
INVENTOR(S)	Jason Edward Bara (Tuscaloosa, Alabama); Kathryn E. O'Harra (Ft. Worth, Texas)
ABSTRACT	Disclosed are compositions and methods of preparing ionic polyamides. Also disclosed are compositions and methods of preparing ionic polyamide-imides. Additionally, disclosed herein are compositions comprising the ionic polyamides or polyamide-imides. The compositions comprising the ionic polyamides or polyamide-imides can include an ionic liquid. The disclosed polyamides and polyamide-imides can be utilized for three-dimensional printing or to capture gases.
FILED	Wednesday, February 14, 2018
APPL NO	15/896513
ART UNIT	1767 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Separation B01D 53/228 (20130101) B01D 71/56 (20130101) B01D 71/58 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/26 (20130101) C08G 73/10 (20130101) C08G 73/14 (20130101) Original (OR) Class C08G 73/0616 (20130101)
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10837001 — Cardiomyocyte maturation platform

US 10837001	Fong et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Science Foundation (NSF) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of The University of California (Oakland, California)
INVENTOR(S)	Ashley H. Fong (Irvine, California); Christopher C. W. Hughes (Irvine, California)
ABSTRACT	Disclosed herein are methods of inducing and/or promoting cardiomyocyte maturation comprising: providing an immature cardiomyocyte; providing a three dimensional (3D) cardiac extracellular matrix (ECM) scaffold; and inducing and/or promoting cardiomyocyte cell maturation by seeding the immature cardiomyocyte in the 3D cardiac ECM scaffold and harvesting once the cardiomyocyte has reached maturity. Also disclosed herein are methods of treating a disease in a mammal comprising transplanting a mature cardiomyocyte into an ischemic heart, wherein the mature cardiomyocyte is generated comprising the steps of: providing an immature cardiomyocyte; providing a 3D cardiac ECM scaffold; and generating mature cardiomyocyte by seeding the immature cardiomyocyte in a 3D cardiac ECM scaffold or co-culturing the immature cardiomyocyte in the presence of endothelial cells or stromal cells; and harvesting once the cardiomyocyte has reached maturity.
FILED	Thursday, March 02, 2017
APPL NO	15/448505
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) A61K 35/34 (20130101) A61K 35/44 (20130101) A61K 35/44 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/0657 (20130101) Original (OR) Class C12N 2501/727 (20130101) C12N 2502/28 (20130101) C12N 2502/45 (20130101) C12N 2503/02 (20130101) C12N 2503/04 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101)
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10837102 — Method and system for graphene formation

US 10837102	Boyd et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	David A. Boyd (La Cañada Flintridge, California); Nai-Chang Yeh (Pasadena, California)
ABSTRACT	A method of forming graphene includes placing a substrate in a processing chamber and introducing a cleaning gas including hydrogen and nitrogen into the processing chamber. The method also includes introducing a carbon source into the processing chamber and initiating a microwave plasma in the processing chamber. The method further includes subjecting the substrate to a flow of the cleaning gas and the carbon source for a predetermined period of time to form the graphene.
FILED	Friday, June 22, 2018
APPL NO	16/015672
ART UNIT	1717 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) C01B 32/186 (20170801) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) Original (OR) Class C23C 16/511 (20130101) C23C 16/4405 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24355 (20150115)
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10837130 — Incandescent tension annealing processes for strong, twist-stable carbon nanotube yarns and muscles

US 10837130	Di et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Army (DOA) Department of the Navy (DON) Office of Naval Research (ONR) Multidisciplinary University Research Initiative (MURI) Non-Profit Organization (NPO) Robert A. Welch Foundation National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Jiangtao Di (Dallas, Texas); Shaoli Fang (Richardson, Texas); Carter S. Haines (Murphy, Texas); Na Li (Dallas, Texas); Ray H. Baughman (Dallas, Texas)
ABSTRACT	The described incandescent tension annealing processes involve thermally annealing twisted or coiled carbon nanotube (CNT) yarns at high-temperatures (1000° C. to 3000° C.) while these yarns are under tensile loads. These processes can be used for increasing yarn modulus and strength and for stabilizing both twisted and coiled CNT yarns with respect to unwanted irreversible untwist, thereby avoiding the need to tether torsional and tensile artificial muscles, and increasing the mechanical loads that can be moved by these muscles.
FILED	Thursday, April 27, 2017
APPL NO	15/498882
ART UNIT	3732 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/02 (20130101) D02G 3/04 (20130101) D02G 3/26 (20130101) Finishing or Dressing of Filaments, Yarns, Threads, Cords, Ropes or the Like D02J 1/22 (20130101) D02J 1/224 (20130101) Original (OR) Class D02J 11/00 (20130101) D02J 13/00 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 10/00 (20130101) D06M 2101/40 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2509/00 (20130101)
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10837802 — Position sensing system with an electromagnet

US 10837802	Wang et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Heng Wang (Minneapolis, Minnesota); Rajesh Rajamani (Saint Paul, Minnesota); Ryan Madson (Minneapolis, Minnesota)
ABSTRACT	A position sensing system for measuring a position of a linearly moving object includes a high magnetic permeability material positioned on the moving object, an electromagnet configured to generate an alternating magnetic field, and at least one magnetic sensor configured to measure an intensity of a first magnetic field that is based on the alternating magnetic field. A controller is configured to estimate a linear position of the moving object based on the measured intensity of the first magnetic field.
FILED	Monday, August 20, 2018
APPL NO	16/105660
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/147 (20130101) G01D 5/2013 (20130101) Original (OR) Class Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/12 (20130101) G01V 3/081 (20130101)
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10837918 — Non-destructive CMAS-infiltration characterization of thermal barrier coatings

US 10837918	Naraparaju et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Deutsches Zentrum für Luft-und Raumfahrt e.V (Cologne, Germany); University of Central Florida Research Foundation, Inc. (Orlando, Florida)
ASSIGNEE(S)	Deutsches Zentrum für Luft-und Raumfahrt e.V (Cologne, Germany); University of Central Florida Research Foundation, Inc. (Orlando, Florida)
INVENTOR(S)	Ravisankar Naraparaju (Cologne, Germany); Uwe Schulz (Cologne, Germany); Seetha Raghavan (Orlando, Florida); Estefania Bohorquez (Orlando, Florida)
ABSTRACT	The present invention provides a non-destructive method of characterizing CMAS infiltration and CMAS assisted damage in thermal barrier coatings (TBCs). Such approach is especially relevant for determining the lifetime of coatings on e.g. turbines or parts of the turbines such as blades or in-liners of the combustion chambers. The turbines can be gas turbines or high-pressure turbines or others and may be stationary or used for example in aviation.
FILED	Friday, March 23, 2018
APPL NO	15/934556
ART UNIT	2886 — Optics
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/288 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/80 (20130101) F05D 2260/83 (20130101) F05D 2300/611 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 21/91 (20130101) Original (OR) Class
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10837926 — Multi-modal spectroscopic analysis

US 10837926	Mandal et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio); University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (Gainesville, Florida)
INVENTOR(S)	Soumyajit Mandal (Shaker Heights, Ohio); Swarup Bhunia (Gainesville, Florida); Naren Vikram Raj Masna (Gainesville, Florida); Cheng Chen (Cleveland, Ohio); Mason Greer (Cleveland, Ohio); Fengchao Zhang (Folsom, California)
ABSTRACT	An example includes performing near infra-red (NIR) spectrometry to provide NIR measurement data for a sample compound. The method also includes performing magnetic resonance (MR) spectrometry to provide MR measurement data for the sample compound. The method also includes analyzing, by a computing device, the MR measurement data in view of the NIR measurement data to characterize the sample compound.
FILED	Tuesday, September 04, 2018
APPL NO	16/121439
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/94 (20130101) G01N 21/359 (20130101) G01N 21/9508 (20130101) G01N 24/08 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/441 (20130101) G01R 33/448 (20130101) G01R 33/4625 (20130101)
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10838279 — Heat-resistant electrolyte materials and electrochromic devices including them

US 10838279	Taya et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Office of Emerging Frontiers in Research and Innovation (EFRI)
APPLICANT(S)	University of Washington (Seattle, Washington)
ASSIGNEE(S)	University of Washington (Seattle, Washington)
INVENTOR(S)	Minoru Taya (Mercer Island, Washington); Nishita Anandan (Seattle, Washington)
ABSTRACT	The present disclosure relates to relates to heat-resistant gel electrolyte materials and their uses, for example, in electrochromic devices such as electrochromic windows. In certain embodiments, the disclosure provides an electrolyte material including a polymer of ethyleneimine, optionally at least partially crosslinked (e.g., with an epoxide crosslinker such as the diglycidyl ether of bisphenol A); a lithium salt (e.g., lithium perchlorate); and a high-boiling solvent (e.g., DMSO). The electrolyte materials can be used in electrochromic devices, such as electrochromic windows, e.g., for use as automobile sunroofs
FILED	Monday, April 02, 2018
APPL NO	15/943030
ART UNIT	2872 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/15 (20130101) G02F 1/0018 (20130101) G02F 1/153 (20130101) G02F 1/155 (20130101) G02F 1/157 (20130101) G02F 1/161 (20130101) G02F 1/163 (20130101) G02F 1/1523 (20130101) G02F 1/1525 (20130101) Original (OR) Class G02F 1/1533 (20130101) G02F 1/15165 (20190101) G02F 2001/1555 (20130101) G02F 2001/15145 (20190101) G02F 2201/44 (20130101)
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10838758 — System and method for self-protecting data

US 10838758	Lee et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computing and Communication Foundations (CCF)
APPLICANT(S)	Teleputers, LLC (Princeton, New Jersey)
ASSIGNEE(S)	Teleputers, LLC (Princeton, New Jersey)
INVENTOR(S)	Ruby B. Lee (Princeton, New Jersey); Pramod A. Jamkhedkar (Bridgewater, New Jersey); Yu-Yuan Chen (Princeton, New Jersey)
ABSTRACT	Disclosed is a system comprising a physical memory, a processor and a software component. The software component includes a policy/domain handler for receiving data and a policy associated with the data; a hypervisor; and a file management module. The file management module receives a request from a third-party application to interact with a data file containing the data; sends an authorization and tag request to the policy/domain handler to check if the user and application are permitted to access the data, and if permitted, to generate hardware tags for the data file; and sends a secure data request to the hypervisor to create a secure data compartment for the data file and the hardware tags. Based on the authorization and tag request, and the security policy associated with the data, the policy/domain handler generates the hardware tags for the data file. Based on the secure data request, the hypervisor creates in the physical memory a secure data compartment containing the data file and the hardware tags, the hypervisor associating the hardware tags with the data in the secure data compartment. As the data is operated upon and moved to other memory areas, the hardware tags are propagated with the data according to tag propagation rules, and checked before performing operations that may lead to security breaches.
FILED	Tuesday, January 22, 2019
APPL NO	16/253937
ART UNIT	2444 — Computer Networks
CURRENT CPC	Electric Digital Data Processing G06F 9/45558 (20130101) Original (OR) Class G06F 21/6227 (20130101) G06F 21/6281 (20130101) G06F 2009/45583 (20130101)
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10839510 — Methods and systems for human tissue analysis using shearlet transforms

US 10839510	Mahoor et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	Colorado Seminary, Owner and Operator of University of Denver (Denver, Colorado)
ASSIGNEE(S)	Colorado Seminary, which owns and operates the University of Denver (Denver, Colorado)
INVENTOR(S)	Mohammad H. Mahoor (Lone Tree, Colorado); Hadi Rezaeilouyeh (Littleton, Colorado); Ali Mollahosseini (Denver, Colorado)
ABSTRACT	Various arrangements for identifying and grading cancer in tissue samples are presented. A digital image of a stained tissue sample may be acquired. A Shearlet transform may be performed on the digital image of the stained tissue sample. Shearlet coefficients may be calculated based on the performed Shearlet transform of the normalized digital RGB image of the stained tissue sample. A trained neural network may be applied to create a plurality of feature maps using the digital image and Shearlet coefficients, wherein the trained neural network was trained using a plurality of images and Shearlet coefficients of a plurality of digital images. A classifier may be applied to an output of the trained neural network to identify whether cancer is present in the stained tissue sample. A notification may be output that is indicative of a grade of detected cancer in the sample.
FILED	Wednesday, August 17, 2016
APPL NO	15/239659
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/527 (20130101) G06K 9/4604 (20130101) G06K 9/6269 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/42 (20170101) G06T 2207/10024 (20130101) G06T 2207/20048 (20130101) G06T 2207/20064 (20130101) G06T 2207/30024 (20130101) G06T 2207/30068 (20130101) G06T 2207/30081 (20130101) G06T 2207/30096 (20130101)
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10840092 — Atomic force microscopy based on nanowire tips for high aspect ratio nanoscale metrology/confocal microscopy

US 10840092	Busani et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Tito Busani (Albuquerque, New Mexico); Steven R. J. Brueck (Albuquerque, New Mexico); Daniel Feezell (Albuquerque, New Mexico); Mahmoud Behzadirad (Albuquerque, New Mexico)
ABSTRACT	Nanowires that may be utilized in microscopy, for example atomic force microscopy (AFM), as part of an AFM probe, as well as for other uses, are disclosed. The nanowires may be formed from a Group III nitride such as an epitaxial layer that may be or include gallium nitride, indium nitride, aluminum nitride, and an alloy of these materials. During use of the AFM probe to measure a topography of a test sample surface, the nanowire can activated and caused to lase and emit a light, thereby illuminating the surface with the light. In an implementation, the light can be collected by the AFM probe itself, for example through an optical fiber to which the nanowire is attached.
FILED	Wednesday, November 29, 2017
APPL NO	16/349918
ART UNIT	2881 — Optics
CURRENT CPC	Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/38 (20130101) G01Q 70/12 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0262 (20130101) H01L 21/02458 (20130101) H01L 21/02603 (20130101) Original (OR) Class H01L 21/02645 (20130101)
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10840157 — Methods for reducing chip testing time using trans-threshold correlations

US 10840157	Lukas et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)	University of Viriginia Patent Foundation (Charlottesville, Virginia)
INVENTOR(S)	Christopher J. Lukas (Charlottesville, Virginia); Benton H. Calhoun (Charlottesville, Virginia); Farah B. Yahya (Charlottesville, Virginia)
ABSTRACT	A method for testing system-on-a-chip (SoC) for faults at subthreshold or substantially at threshold operating voltages includes the steps of testing the SoC for fault at a favorable operating voltage, the testing including measuring a metric characterizing the fault at the favorable operating voltage to obtain a first metric value; and retesting the SoC for the fault at a first operating voltage upon the first metric value at the favorable operating voltage being correlated, according to a metric correlation establishing a correlation relationship between the favorable operating voltage and the first operating voltage, to a second metric value at the first operating voltage within a predictive interval of the metric correlation.
FILED	Monday, June 04, 2018
APPL NO	15/997652
ART UNIT	2864 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 31/30 (20130101) G01R 31/3004 (20130101) G01R 31/31718 (20130101) G01R 31/31725 (20130101) Electric Digital Data Processing G06F 17/15 (20130101) G06F 30/367 (20200101) G06F 2111/08 (20200101) Static Stores G11C 29/04 (20130101) G11C 29/50004 (20130101) G11C 29/50012 (20130101) G11C 29/56008 (20130101) G11C 2029/0403 (20130101) G11C 2029/5004 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 22/20 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 7/042 (20130101)
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10840302 — Image sensor including nanostructure color filter

US 10840302	Han et al.
FUNDED BY	National Science Foundation (NSF)
APPLICANT(S)	SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Seunghoon Han (Seoul, South Korea); Kwanghee Lee (Hwaseong-si, South Korea); Yongwan Jin (Seoul, South Korea); Yongsung Kim (Suwon-si, South Korea); Changgyun Shin (Anyang-si, South Korea); Jeongyub Lee (Yongin-si, South Korea); Amir Arbabi (Pasadena, California); Andrei Faraon (Pasadena, California); Yu Horie (Pasadena, California)
ABSTRACT	An image sensor includes a first light sensor layer including light sensing cells configured to sense first light of an incident light and generate electrical signals based on the sensed first light, and a color filter array layer disposed on the first light sensor layer, and including color filters respectively facing the light sensing cells. The image sensor further includes a second light sensor layer disposed on the color filter array layer, and configured to sense second light of the incident light and generate an electrical signal based on the sensed second light. Each of the color filters includes a nanostructure including a first material having a first refractive index, and a second material having a second refractive index greater than the first refractive index, the first material and the second material being alternately disposed with a period.
FILED	Thursday, March 30, 2017
APPL NO	15/473767
ART UNIT	2893 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/307 (20130101) Original (OR) Class H01L 27/14621 (20130101) H01L 27/14636 (20130101) H01L 27/14645 (20130101)
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10840536 — Stretchable electronic systems with containment chambers

US 10840536	Rogers et al.
FUNDED BY	Department of Energy (DOE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS) Office of The Director (OD) Office of International Science and Engineering (OISE)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois); NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois); Northwestern University (Evanston, Illinois)
INVENTOR(S)	John A. Rogers (Champaign, Illinois); Sheng Xu (Urbana, Illinois); Jonathan A. Fan (Columbus, Ohio); Yonggang Huang (Glencoe, Illinois); Yihui Zhang (Evanston, Illinois); Lin Jia (Boston, Massachusetts)
ABSTRACT	The present invention provides electronic systems, including device arrays, comprising functional device(s) and/or device component(s) at least partially enclosed via one or more containment chambers, such that the device(s) and/or device component(s) are at least partially, and optionally entirely, immersed in a containment fluid. Useful containment fluids for use in containment chambers of electronic devices of the invention include lubricants, electrolytes and/or electronically resistive fluids. In some embodiments, for example, electronic systems of the invention comprise one or more electronic devices and/or device components provided in free-standing and/or tethered configurations that decouple forces originating upon deformation, stretching or compression of a supporting substrate from the free standing or tethered device or device component.
FILED	Wednesday, February 05, 2014
APPL NO	14/766301
ART UNIT	2848 — Electrical Circuits and Systems
CURRENT CPC	Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/26 (20130101) H01G 11/78 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/54 (20130101) H01L 23/18 (20130101) H01L 23/22 (20130101) H01L 2224/16225 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/00 (20130101) H01L 2924/12032 (20130101) H01L 2924/12032 (20130101) H01L 2924/12041 (20130101) H01L 2924/12041 (20130101) H01L 2924/12042 (20130101) H01L 2924/12042 (20130101) H01L 2924/12043 (20130101) H01L 2924/12043 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/0202 (20130101) H01M 2/204 (20130101) H01M 2/206 (20130101) H01M 2/0237 (20130101) H01M 8/02 (20130101) H01M 10/02 (20130101) Original (OR) Class H01M 10/0525 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/189 (20130101) H05K 1/0283 (20130101) H05K 2201/0133 (20130101) H05K 2201/09263 (20130101) H05K 2201/10037 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49126 (20150115)
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10840829 — Rechargeable battery device

US 10840829	Khizroev et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	Sakhrat Khizroev (Miami, Florida); Rakesh Guduru (Miami, Florida)
ASSIGNEE(S)	The Florida International University Board of Trustees (Miami, Florida)
INVENTOR(S)	Sakhrat Khizroev (Miami, Florida); Rakesh Guduru (Miami, Florida)
ABSTRACT	A compact magnetic-based battery device that offers energy, a large number of cycles, a long storage time, and a short charging time is provided. The rechargeable battery device can include a first magnetic layer, a second magnetic layer, a dielectric layer disposed between the first magnetic layer and the second magnetic layer, and a plurality of high anisotropic magnetic nanoparticles embedded into the dielectric layer.
FILED	Friday, June 01, 2018
APPL NO	15/995639
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/00 (20130101) H01L 41/06 (20130101) H01L 41/16 (20130101) H01L 41/20 (20130101) H01L 41/125 (20130101) Electric Machines Not Otherwise Provided for H02N 2/186 (20130101) Original (OR) Class
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10840925 — Harmonic injection locking apparatus, methods, and applications

US 10840925	Delfyett et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Direct On-Chip Digital Optical Synthesizer Program (DODOS) National Science Foundation (NSF)
APPLICANT(S)	University of Central Florida Research Foundation, Inc. (Orlando, Florida)
ASSIGNEE(S)	UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
INVENTOR(S)	Peter J. Delfyett (Orlando, Florida); Ricardo Bustos Ramirez (Orlando, Florida); Michael E. Plascak (Orlando, Florida)
ABSTRACT	Apparatus and methods demonstrate a chip-scale direct optical to RF link that frequency divides up to 120 GHz optical frequency combs to 10 GHz using harmonic multi-tone injection locking. The embodied invention links widely separated optical frequency combs in the millimeter wave regime (>120 GHz) or THz domain (100s of GHz to THz domain), e.g., microresonator-based frequency combs, which are currently outside of the photo-detection region, into the microwave domain (10s of GHz) where it can be easily photo-detected and controlled. The technique works as a perfect optical divider, using a mode-locked laser and optical injection locking as the technique to phase-lock both lasers.
FILED	Monday, May 13, 2019
APPL NO	16/410401
ART UNIT	2849 — Electrical Circuits and Systems
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1121 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/20 (20130101) Original (OR) Class
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National Aeronautics and Space Administration (NASA)

10836137 — Holey graphene mesh and solvent-free manufacturing and composites thereof

US 10836137	Lin et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
INVENTOR(S)	Yi Lin (Yorktown, Virginia); John W. Connell (Yorktown, Virginia); John W. Hopkins (Suffolk, Virginia); Brandon Moitoso (Oviedo, Florida)
ABSTRACT	Systems, methods, and devices of the various embodiments provide for the creation of holey graphene meshes (HGMs) and composite articles including HGMs. Various embodiments provide solvent-free methods for creating arrays of holes on holey graphene-based articles formed from dry compression (such as films, discs, pellets), thereby resulting in a HGM. In further embodiments, a HGM can used as part of a composite, such as by: 1) embedding a HGM into another matrix material such as carbon, polymer, metals, metal oxides, etc; and/or (2) the HGM serving as a matrix by filling the holes of the HGM or functionalizing the HGM body with another one or more materials. In various embodiments, HGM can also be made as a composite itself by creating holes on dry-compressed articles pre-embedded with one or more other materials.
FILED	Friday, July 20, 2018
APPL NO	16/040627
ART UNIT	1767 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 9/007 (20130101) Original (OR) Class B32B 2264/105 (20130101) B32B 2305/026 (20130101) B32B 2305/38 (20130101) B32B 2311/06 (20130101) B32B 2311/18 (20130101) B32B 2311/30 (20130101) B32B 2457/10 (20130101) B32B 2457/16 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/194 (20170801) C01B 2204/22 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/03 (20130101)
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10836515 — Pressure-assisted linear seal

US 10836515	Doggett et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINSTRATOR OF NASA (Washington, District of Columbia)
INVENTOR(S)	William R. Doggett (Poquoson, Virginia); Timothy S. Roach (Virginia Beach, Virginia); Jerry E. Warren (Hampton, Virginia); Judith J. Watson (Yorktown, Virginia); Thomas C. Jones (Newport News, Virginia); Richard K Bird (Grafton, Virginia); Vincenzo M. Le Boffe (Carrollton, Virginia); William M. Langford (Hampton, Virginia); Lana P. Hicks-Olson (Surry, Virginia); Samuel James (Portsmouth, Virginia); Clarence E. Stanfield (Hampton, Virginia); Alberto Makino (Stanford, California); Bryan C. Yount (Sunnyvale, California); Khadijah I. Shariff (Houston, Texas); Molly M. Selig (League City, Texas); Douglas A. Litteken (Houston, Texas); Winfred S. Kenner (Yorktown, Virginia); David F. Moore (Poquoson, Virginia); Danny J. Lovaglio (Virgina Beach, Virginia); Laura A. Leybold (Hampton, Virginia); Earl T. Hall (Newport News, Virginia); James E. Phelps (Smithfield, Virginia); Arlon B. Sullivan (Chesapeake, Virginia); Fred M. Whitehead (Newport News, Virginia)
ABSTRACT	An inflatable pressure structure includes an airtight flexible membrane having collapsed and inflated configurations. The inflatable pressure structure includes an elongated pressure-assisted seal that is configured to selectively seal an opening in the airtight flexible membrane. The pressure-assisted seal includes first and second seal components that sealingly engage one another and prevent escape of gas from inside the airtight flexible membrane. The airtight flexible membrane, when inflated, generates a force transverse to the pressure-assisted seal tending to pull the first and second seal components apart. Pressurized gas inside the airtight flexible membrane causes the first and second seal components to more securely engage one another whereby a force transverse to the pressure-assisted seal does not disengage the first and second seal components.
FILED	Friday, August 31, 2018
APPL NO	16/119293
ART UNIT	3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/10 (20130101) B64G 1/12 (20130101) B64G 1/66 (20130101) Original (OR) Class B64G 2001/224 (20130101)
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10838024 — Self-calibrating solid-state magnetometer for vectorized field sensing via zero-field spin-dependent recombination

US 10838024	Cochrane
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S)	Corey J. Cochrane (Pasadena, California)
ABSTRACT	A self-calibrating solid-state magnetometer for vectorized field sensing via zero-field spin-dependent recombination is realized with a wide band gap semiconductor junction. Three sets of Helmholtz coils provide a cancellation field at low frequency, as well as a modulated field at audio frequencies. The presence of the hyperfine interactions in the zero-field response as well as the low-field electrically detected magnetic resonance detection capability allows for magnetometer self-calibration.
FILED	Wednesday, May 02, 2018
APPL NO	15/969466
ART UNIT	2866 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0017 (20130101) G01R 33/022 (20130101) G01R 33/0035 (20130101) G01R 33/091 (20130101) Original (OR) Class G01R 33/0206 (20130101) G01R 33/1284 (20130101)
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10840074 — Systems and methods for conducting neutral loss scans in a single ion trap

US 10840074	Cooks et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Robert Graham Cooks (West Lafayette, Indiana); Dalton Snyder (West Lafayette, Indiana)
ABSTRACT	The invention generally relates to systems and methods for conducting neutral loss scans in a single ion trap. In certain aspects, the invention provides systems that include a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a scan function that excites a precursor ion, rejects the precursor ion after its excitation, and ejects a product ion in the single ion trap.
FILED	Friday, January 24, 2020
APPL NO	16/751265
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/0036 (20130101) Original (OR) Class H01J 49/0081 (20130101) H01J 49/422 (20130101) H01J 49/429 (20130101)
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10840405 — Inductively coupled plasma for hydrogenation of type II superlattices

US 10840405	Boieriu et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	Paul Boieriu (Lake Zurich, Illinois); Christoph H Grein (Wheaton, Illinois)
ASSIGNEE(S)	Sivananthan Laboratories, Inc. (Bolingbrook, Illinois)
INVENTOR(S)	Paul Boieriu (Lake Zurich, Illinois); Christoph H Grein (Wheaton, Illinois)
ABSTRACT	A process and apparatus is provided to generate and introduce hydrogen from an inductively coupled plasma system into a type II superlattice wafer. The type II superlattice wafer can contain a number of detectors formed on one of its faces. The process can use hydrogen plasma with a total chamber pressure of 20-300 mTorr, a hydrogen gas flow of 50-100 sccm, an ICP power of 100-900 W, a secondary RF power of 15-90 W, and a process duration adjusted to maximize the benefit of hydrogenation (typically between several tens and several hundreds of seconds). The process can introduce a secondary gas to facilitate the plasma ignition, hydrogen ionization and recombination processes or hydrogen diffusion and impingement onto the type II superlattice wafer.
FILED	Tuesday, October 31, 2017
APPL NO	15/799990
ART UNIT	2812 — Semiconductors/Memory
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 37/3211 (20130101) H01J 37/32183 (20130101) H01J 37/32449 (20130101) H01J 37/32715 (20130101) H01J 37/32834 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0304 (20130101) H01L 31/1868 (20130101) Original (OR) Class H01L 31/03046 (20130101) H01L 31/035236 (20130101)
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10840504 — High performance inorganic complexes for next-generation redox flow batteries

US 10840504	Jones et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S)	CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)	California Institute of Technology (Pasadena, California)
INVENTOR(S)	Simon C. Jones (Whittier, California); Emmanuelle Despagnet-Ayoub (Pasadena, California); Brendon McNicholas (North Hollywood, California); Harry B. Gray (Pasadena, California); Robert H. Grubbs (South Pasadena, California); Danh Ngo (Pasadena, California)
ABSTRACT	In an aspect, a redox flow battery comprises a catholyte and an anolyte; wherein at least one of said catholyte and said anolyte is a metal-coordination complex, said metal-coordination complex comprising: (i) a metal; (ii) one or more first ligands coordinated with said metal atom, wherein each of said first ligands is independently a Lewis basic ligand; and one or more second ligands associated with said one or more first ligands, wherein each of said second ligands is independently a Lewis acid ligand; and a nonaqueous solvent, wherein said catholyte, said anolyte or both are dissolved in said nonaqueous solvent. One or more first ligands may be provided in a primary coordination sphere of said metal-coordination complex and one or more second ligands may be provided in a secondary coordination sphere of said metal-coordination complex. The one or more first ligands independently may comprise a Lewis basic functional group and each of said one or more second ligands independently may comprise a Lewis acidic functional group.
FILED	Friday, February 23, 2018
APPL NO	15/903553
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 11/00 (20130101) C07F 13/00 (20130101) C07F 15/02 (20130101) C07F 15/06 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/368 (20130101) Original (OR) Class H01M 4/9008 (20130101) H01M 8/188 (20130101) H01M 8/0202 (20130101) H01M 2300/0025 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/528 (20130101)
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Department of Agriculture (USDA)

10836809 — Mosaic chimeric viral vaccine particle

US 10836809	Mwangi et al.
FUNDED BY	Department of Agriculture (USDA) Agricultural Research Service (ARS) Cooperative State Research, Education, and Extension Service (CSREES) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	The Texas A and M University System (College Station, Texas)
ASSIGNEE(S)	The Texas A and M University System (College Station, Texas)
INVENTOR(S)	Waithaka Mwangi (College Station, Texas); Surya Waghela (College Station, Texas); Luc Berghman (College Station, Texas)
ABSTRACT	The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.
FILED	Friday, July 19, 2019
APPL NO	16/516473
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/761 (20130101) A61K 39/42 (20130101) A61K 2039/55522 (20130101) Peptides C07K 16/081 (20130101) Original (OR) Class C07K 16/1081 (20130101) C07K 16/2851 (20130101) C07K 2317/31 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) C07K 2317/626 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/10343 (20130101) C12N 2770/24334 (20130101) C12N 2810/855 (20130101)
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10836929 — Polyester polymers comprising lignin

US 10836929	Bowman et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	PPG Industries Ohio, Inc. (Cleveland, Ohio)
ASSIGNEE(S)	PPG Industries Ohio, Inc. (Cleveland, Ohio)
INVENTOR(S)	Mark Paul Bowman (New Kensington, Pennsylvania); Carole A. Conley (Saxonburg, Pennsylvania); Irina G. Schwendeman (Wexford, Pennsylvania); Mercy M. Hibbert (Alphington, Australia)
ABSTRACT	Disclosed is a polyester polymer prepared from a reaction mixture comprising a polyacid component and a polyol component that comprises lignin. Residues of lignin are incorporated into the backbone of the polyester polymer. Coatings comprising the same and substrates coated at least in part with such coatings are also disclosed.
FILED	Wednesday, December 06, 2017
APPL NO	15/833592
ART UNIT	1787 — Miscellaneous Articles, Stock Material
CURRENT CPC	Processes for Applying Fluent Materials to Surfaces, in General B05D 3/02 (20130101) B05D 3/0254 (20130101) B05D 7/14 (20130101) B05D 7/16 (20130101) B05D 7/50 (20130101) B05D 7/51 (20130101) B05D 7/52 (20130101) B05D 7/53 (20130101) B05D 7/54 (20130101) B05D 2202/10 (20130101) B05D 2202/25 (20130101) B05D 2350/65 (20130101) B05D 2401/10 (20130101) B05D 2401/40 (20130101) B05D 2420/01 (20130101) B05D 2425/01 (20130101) B05D 2508/00 (20130101) B05D 2602/00 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/04 (20130101) B32B 15/08 (20130101) B32B 15/09 (20130101) B32B 15/012 (20130101) B32B 15/043 (20130101) B32B 27/20 (20130101) B32B 27/36 (20130101) B32B 2250/02 (20130101) B32B 2250/03 (20130101) B32B 2255/06 (20130101) B32B 2255/26 (20130101) B32B 2255/28 (20130101) B32B 2307/752 (20130101) B32B 2311/20 (20130101) B32B 2311/24 (20130101) B32B 2311/30 (20130101) B32B 2367/00 (20130101) Compounds of Unknown Constitution C07G 1/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/12 (20130101) C08G 63/20 (20130101) C08G 63/133 (20130101) Derivatives of Natural Macromolecular Compounds C08H 6/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 7/042 (20130101) C08J 2367/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/011 (20180101) C08K 3/013 (20180101) C08K 5/0025 (20130101) Compositions of Macromolecular Compounds C08L 67/00 (20130101) C08L 67/02 (20130101) C08L 67/03 (20130101) C08L 67/08 (20130101) C08L 97/005 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/40 (20180101) C09D 7/65 (20180101) C09D 167/00 (20130101) C09D 167/02 (20130101) C09D 167/03 (20130101) C09D 167/08 (20130101) C09D 197/00 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 428/3179 (20150401) Y10T 428/31681 (20150401) Y10T 428/31786 (20150401)
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PP032459 — Corylus plant named ‘PollyO’

US PP32459	Mehlenbacher et al.
FUNDED BY	Department of Agriculture (USDA) Agricultural Research Service (ARS) National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) Specialty Crop Research Initiative (SCRI)
APPLICANT(S)	Oregon State University (Corvallis, Oregon)
ASSIGNEE(S)	Oregon State University (Corvallis, Oregon)
INVENTOR(S)	Shawn A. Mehlenbacher (Corvallis, Oregon); David C. Smith (Corvallis, Oregon); Rebecca L. McCluskey (Corvallis, Oregon)
ABSTRACT	A new and distinct Corylus plant named ‘PollyO’ is characterized by high nut yield, early nut maturity, small round nuts and kernels, high kernel percentage, good kernel blanching and excellent flavor. The tree is vigorous and has a desirable growth habit. ‘PollyO’ is resistant to bud mite (primarily Phytoptus avellanae Nal.). DNA markers and field exposure indicate that it is highly resistant to eastern filbert blight (EFB) caused by Anisogramma anomala (Peck) E. Müller.
FILED	Friday, June 29, 2018
APPL NO	15/998094
ART UNIT	1661 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/08 (20130101) A01H 6/00 (20180501) Original (OR) Class
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PP032468 — Cornus florida tree named ‘Erica's Appalachian Sunrise’

US PP32468	Trigiano et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
ASSIGNEE(S)	UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
INVENTOR(S)	Robert N. Trigiano (Knoxville, Tennessee); Phillip A. Wadl (Charleston, South Carolina)
ABSTRACT	A new and distinct cultivar of flowering dogwood tree, which produces both fully dark red bracts and lighter red to pink bracts is provided. This dogwood tree is botanically known as Cornus florida and referred to by the following cultivar name: ‘Erica's Appalachian Sunrise’.
FILED	Friday, July 26, 2019
APPL NO	16/602052
ART UNIT	1661 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/00 (20180501) Original (OR) Class
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Department of Commerce (DOC)

10836798 — Amino acid-specific binder and selectively identifying an amino acid

US 10836798	Tullman et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)	GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Gaithersburg, Maryland)
INVENTOR(S)	Jennifer A. Tullman (Germantown, Maryland); Zvi Kelman (Gaithersburg, Maryland); John P. Marino (Silver Spring, Maryland)
ABSTRACT	An amino acid-specific binder selectively binds to a binding amino acid. A binder complex selectively identifies the binding amino acid and includes an adjunct attached to the amino acid-specific binder. The adjunct includes a taggant, protein, substrate, or chemical modifier. Selectively identifying an N-terminal amino acid includes anchoring a C-terminal end; contacting an N-terminal amino acid of the anchored analyte with the binder complex; selectively binding when the N-terminal amino acid includes the binding amino acid; producing, by the taggant of the tagged complex, a taggant signal; detecting the taggant signal; and identifying the N-terminal amino acid based on the taggant signal.
FILED	Friday, April 26, 2019
APPL NO	16/395407
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 1/13 (20130101) C07K 14/195 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101)
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10837828 — Non-attenuating meter for determining optical energy of laser light

US 10837828	Lehman et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)	GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Gaithersburg, Maryland)
INVENTOR(S)	John H. Lehman (Boulder, Colorado); Matthew T. Spidell (Westminster, Colorado); Joshua A. Hadler (Lyons, Colorado); Paul A. Williams (Erie, Colorado)
ABSTRACT	A non-attenuating meter determines optical energy of laser light in an absence of optical attenuation of the laser light and includes: a recipient mirror that: receives laser light that propagates in a primary propagation direction; produces profile light; transmits the profile light through the recipient mirror along the primary propagation direction; produces first reflected light from the laser light; and reflects the first reflected light along a secondary propagation direction; a profilometer in optical communication with the recipient mirror and that: receives the profile light from the recipient mirror along the primary propagation direction; and produces a profile signal from the profile light; a sensor mirror in optical communication with the recipient mirror and a passer mirror and that: receives the first reflected light from the recipient mirror along the secondary propagation direction; produces, in a tertiary direction, a sensor force from the first reflected light; communicates the sensor force to a force sensor along the tertiary direction; produces a second reflected light from the first reflected light; and reflects the second reflected light in a tertiary propagation direction; the passer mirror in optical communication with the sensor mirror and that: receives, along the tertiary propagation direction, the second reflected light from the sensor mirror; produces pass light from the second reflected light; and reflects the pass light along the primary propagation direction, such that the non-attenuating meter does not attenuate the optical energy of the laser light and does not change the primary propagation direction of the laser light.
FILED	Wednesday, July 24, 2019
APPL NO	16/520643
ART UNIT	2886 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/56 (20130101) Original (OR) Class G01J 1/0414 (20130101)
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Non-Profit Organization (NPO)

10835549 — Polyplexes

US 10835549	Duvall et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) Non-Profit Organization (NPO) American Heart Association (AHA) National Science Foundation (NSF)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee); The United States as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee); The United States as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Craig Duvall (Nashville, Tennessee); Brian Connor Evans (Bartlett, Tennessee); Colleen Brophy (Nashville, Tennessee); Kyle Hocking (Alpharetta, Georgia)
ABSTRACT	The present disclosure relates to compounds comprising (i) an active agent, wherein the active agent includes a charge at a predetermined pH, (ii) a polymer, wherein the polymer includes an opposite charge than the active agent at the predetermined pH; and (iii) a polyplex comprising the peptide and the polymer electrostatically bond together at the predetermined pH. In some embodiments, the active agent is a peptide, such as a peptide comprising MAPKAP kinase II inhibitory peptide, and in some embodiments the peptide includes a cell-penetrating peptide. In further embodiments, the disclosure provides methods for treating a disease or condition by administering a composition according to the present disclosure to a subject in need thereof.
FILED	Friday, April 11, 2014
APPL NO	14/784017
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/711 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 38/005 (20130101) A61K 38/55 (20130101) A61K 38/55 (20130101) A61K 47/32 (20130101) A61K 47/58 (20170801) A61K 47/6927 (20170801) A61K 2300/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 2300/252 (20130101)
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10837130 — Incandescent tension annealing processes for strong, twist-stable carbon nanotube yarns and muscles

US 10837130	Di et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Army (DOA) Department of the Navy (DON) Office of Naval Research (ONR) Multidisciplinary University Research Initiative (MURI) Non-Profit Organization (NPO) Robert A. Welch Foundation National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)	Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S)	Jiangtao Di (Dallas, Texas); Shaoli Fang (Richardson, Texas); Carter S. Haines (Murphy, Texas); Na Li (Dallas, Texas); Ray H. Baughman (Dallas, Texas)
ABSTRACT	The described incandescent tension annealing processes involve thermally annealing twisted or coiled carbon nanotube (CNT) yarns at high-temperatures (1000° C. to 3000° C.) while these yarns are under tensile loads. These processes can be used for increasing yarn modulus and strength and for stabilizing both twisted and coiled CNT yarns with respect to unwanted irreversible untwist, thereby avoiding the need to tether torsional and tensile artificial muscles, and increasing the mechanical loads that can be moved by these muscles.
FILED	Thursday, April 27, 2017
APPL NO	15/498882
ART UNIT	3732 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC	Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/02 (20130101) D02G 3/04 (20130101) D02G 3/26 (20130101) Finishing or Dressing of Filaments, Yarns, Threads, Cords, Ropes or the Like D02J 1/22 (20130101) D02J 1/224 (20130101) Original (OR) Class D02J 11/00 (20130101) D02J 13/00 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 10/00 (20130101) D06M 2101/40 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2509/00 (20130101)
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Central Intelligence Agency (CIA)

10841086 — Facilitating communications using hybrid cryptography

US 10841086	Alwen
FUNDED BY	Central Intelligence Agency (CIA)
APPLICANT(S)	Wickr Inc. (San Francisco, California)
ASSIGNEE(S)	Wickr, Inc. (Pleasanton, California)
INVENTOR(S)	Joël Alwen (Vienna, Austria)
ABSTRACT	The present application describes a method, system, and non-transitory computer-readable medium for exchanging encrypted communications using hybrid encryption. According to the present disclosure, a first device receives an encrypted communication from a second device. The encrypted communication includes a first encrypted secret, a second encrypted secret, a first signature, and a second signature. The first device verifies the first signature and the second signature, and, when the first and second signatures are valid, decrypts the first encrypted secret using a first encryption algorithm and the second encrypted secret using a second encryption algorithm. The first device combines the first decrypted secret and the second decrypted secret to recover a first communication and provides the first communication to a user of the first device.
FILED	Tuesday, February 06, 2018
APPL NO	15/889343
ART UNIT	2494 — Cryptography and Security
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 9/16 (20130101) H04L 9/085 (20130101) Original (OR) Class H04L 9/0822 (20130101) H04L 9/0844 (20130101) H04L 9/0861 (20130101) H04L 9/3247 (20130101) H04L 63/0428 (20130101)
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Department of Veterans Affairs (DVA)

10835549 — Polyplexes

US 10835549	Duvall et al.
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) Non-Profit Organization (NPO) American Heart Association (AHA) National Science Foundation (NSF)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee); The United States as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	Vanderbilt University (Nashville, Tennessee); The United States as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Craig Duvall (Nashville, Tennessee); Brian Connor Evans (Bartlett, Tennessee); Colleen Brophy (Nashville, Tennessee); Kyle Hocking (Alpharetta, Georgia)
ABSTRACT	The present disclosure relates to compounds comprising (i) an active agent, wherein the active agent includes a charge at a predetermined pH, (ii) a polymer, wherein the polymer includes an opposite charge than the active agent at the predetermined pH; and (iii) a polyplex comprising the peptide and the polymer electrostatically bond together at the predetermined pH. In some embodiments, the active agent is a peptide, such as a peptide comprising MAPKAP kinase II inhibitory peptide, and in some embodiments the peptide includes a cell-penetrating peptide. In further embodiments, the disclosure provides methods for treating a disease or condition by administering a composition according to the present disclosure to a subject in need thereof.
FILED	Friday, April 11, 2014
APPL NO	14/784017
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/711 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 38/005 (20130101) A61K 38/55 (20130101) A61K 38/55 (20130101) A61K 47/32 (20130101) A61K 47/58 (20170801) A61K 47/6927 (20170801) A61K 2300/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 2300/252 (20130101)
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Department of the Interior (DOI)

10838065 — Localization using 2D maps which capture vertical structures in 3D point data

US 10838065	Olson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Office of Naval Research (ONR) Department of the Interior (DOI)
APPLICANT(S)	The Regents of The University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S)	Edwin Olson (Ann Arbor, Michigan); Carl Kershaw (Ann Arbor, Michigan)
ABSTRACT	Autonomous vehicles require precise localization to support safe and reliable operation. Current systems aim to localize in 6DOF based on observations from a combination of cameras and 3D LiDAR, matching against dense, 3D prior maps. These maps are quite large and complex, presenting both computational and physical challenges in terms of matching, storage, and retrieval. Most of the environments where vehicles operate in contain frequent and distinct vertical structure sufficient for 2D localization, while state-of-the-art IMUs can be used to recover roll and pitch. This disclosure introduces a fast method for constructing 2D maps summarizing the vertical structure in the environment and demonstrate that it can be used to localize accurately in vehicular and other applications.
FILED	Friday, January 26, 2018
APPL NO	15/881026
ART UNIT	3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4808 (20130101) G01S 17/42 (20130101) G01S 17/89 (20130101) Original (OR) Class G01S 17/931 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00805 (20130101) Image Data Processing or Generation, in General G06T 11/206 (20130101)
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Department of the Treasury (TREASURY)

10838218 — Optical structures providing dichroic effects

US 10838218	Phillips et al.
FUNDED BY	Department of the Treasury (TREASURY) Bureau of Engraving and Printing (BEP)
APPLICANT(S)	WAVEFRONT TECHNOLOGY, INC. (Paramount, California)
ASSIGNEE(S)	WAVEFRONT TECHNOLOGY, INC. (Paramount, California)
INVENTOR(S)	Roger Winston Phillips (Santa Rosa, California); Christopher Chapman Rich (Rancho Palos Verdes, California); Joel Mikael Petersen (Valley Village, California)
ABSTRACT	A document, product, or package, such as a banknote, passport or the like comprises structures having dichroic effects that change color with viewing angle in both transmission and reflection. Such structures can be useful as security features that counter the ability to effectively use counterfeit documents, products, packages, etc.
FILED	Friday, August 03, 2018
APPL NO	16/054898
ART UNIT	2879 — Optics
CURRENT CPC	Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00865 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/24 (20141001) B42D 25/29 (20141001) B42D 25/30 (20141001) B42D 25/45 (20141001) Optical Elements, Systems, or Apparatus G02B 1/10 (20130101) G02B 27/095 (20130101) Original (OR) Class G02B 27/0977 (20130101)
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U.S. Agency for International Development (USAID)

10836811 — Broadly neutralizing human immunodeficiency virus type 1 (HIV-1) GP120-specific monoclonal antibody

US 10836811	Chan-Hui et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) U.S. Agency for International Development (USAID)
APPLICANT(S)	Theraclone Sciences, Inc. (Seattle, Washington); The Scripps Research Institute (La Jolla, California); International AIDS Vaccine Initiative (New York, New York)
ASSIGNEE(S)	Theraclone Sciences, Inc. (Seattle, Washington); The Scripps Research Institute (La Jolla, California); International AIDS Vaccine Initiative (New York, New York)
INVENTOR(S)	Po-Ying Chan-Hui (Bellevue, Washington); Katherine Doores (San Diego, California); Michael Huber (Zurich, Switzerland); Stephen Kaminsky (Bronx, New York); Steven Frey (Redmond, Washington); Ole Olsen (Everett, Washington); Jennifer Mitcham (Redmond, Washington); Matthew Moyle (Redmond, Washington); Sanjay K. Phogat (Edison, New Jersey); Dennis R. Burton (La Jolla, California); Laura Majorie Walker (San Diego, California); Pascal Raymond Georges Poignard (San Diego, California); Wayne Koff (Stony Brook, New York); Melissa Danielle De Jean De St. Marcel Simek-Lemos (Brooklyn, New York)
ABSTRACT	The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
FILED	Tuesday, September 12, 2017
APPL NO	15/701679
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/51 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

United States Postal Service (USPS)

10841748 — Evacuation tracking

US 10841748	Johnson et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
INVENTOR(S)	Jeffrey C. Johnson (Annapolis, Maryland); Leonetta J. Jackson (Dublin, California); Srinivasa R. Chappidi (Cupertino, California); Dongni S. Growney (Belmont, California); Bijai T. Nidhiri (Fremont, California); Danny Tan (San Francisco, California); Jini J. Thokalath (Foster City, California); Gang Yin (Fremont, California)
ABSTRACT	A computer implemented technique of tracking an evacuation of a location in an environment that utilizes physical tokens to prove physical presence at the location is presented. The technique includes receiving, by a mobile device of an evacuation facilitator, a selection from among choices including at least a real emergency and a simulated emergency; receiving wirelessly, by the mobile device, organization hierarchy data; receiving wirelessly, by the mobile device, physical token based location status information for each of a plurality of subordinates of the evacuation facilitator; displaying, by the mobile device, and based on physical token based location status information, a physical presence status at the location for each of the plurality of subordinates; receiving, by the mobile device, evacuation status information; and recording in remote persistent memory the evacuation status information, such that a second mobile device of a second evacuation facilitator displays at least the evacuation status information.
FILED	Monday, December 02, 2019
APPL NO	16/699922
ART UNIT	2642 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC	Wireless Communication Networks H04W 4/12 (20130101) H04W 4/021 (20130101) H04W 4/029 (20180201) Original (OR) Class H04W 4/90 (20180201) H04W 12/06 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

10837309 — Retention clip for variable vane arm

US 10837309	Pratt et al.
FUNDED BY
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	William S. Pratt (West Hartford, Connecticut); Matthew E. Bintz (West Hartford, Connecticut)
ABSTRACT	A vane arm assembly for a gas turbine engine includes a vane stem having a circumferential groove axially spaced from an outer end of the vane stem. The assembly also includes a vane arm defining an arm aperture that the vane stem is disposed within. The assembly further includes a mechanical fastener retaining an axial position of the vane arm in the axial direction. The assembly yet further includes a retention clip having a base portion and at least one clip arm, the base portion defining a clip aperture that the vane stem is disposed within, the base portion disposed within the circumferential groove of the vane stem to couple the retention clip to the vane stem, the at least one clip arm including a retention member engaged with the vane arm to provide redundant axial retention of the vane arm.
FILED	Tuesday, April 09, 2019
APPL NO	16/379179
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/042 (20130101) F01D 17/162 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/50 (20130101) F05D 2260/79 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10837318 — Buffer system for gas turbine engine

US 10837318	Glahn et al.
FUNDED BY
APPLICANT(S)	United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	Jorn Axel Glahn (Manchester, Connecticut); Taryn Narrow (Glastonbury, Connecticut); Anthony Spagnoletti (Newington, Connecticut); Francis Parnin (Suffield, Connecticut); Justin W. Heiss (Glastonbury, Connecticut)
ABSTRACT	This disclosure relates to a buffer system for a gas turbine engine. An exemplary gas turbine engine includes, among other features, a buffer manifold in an intershaft region. The buffer manifold is configured to direct a flow of air between a first air seal and a first oil seal, and to direct another flow of air between a second air seal and a second oil seal.
FILED	Tuesday, January 08, 2019
APPL NO	16/242345
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/162 (20130101) F01D 25/183 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/50 (20130101) F05D 2240/55 (20130101) F05D 2260/98 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10837931 — Classifying and identifying materials based on permittivity features

US 10837931	Donnangelo et al.
FUNDED BY
APPLICANT(S)	THE MITRE CORPORATION (McLean, Virginia)
ASSIGNEE(S)	The MITRE Corporation (McLean, Virginia)
INVENTOR(S)	Nicholas C. Donnangelo (Purcellville, Virginia); Alexander V. Mamishev (Seattle, Washington); Walter S. Kuklinski (Princeton, Massachusetts)
ABSTRACT	Systems and methods are provided for remotely identifying and classifying materials based on their respective complex permittivity features. Materials of interest to be identified in later inspections are cataloged according to their respective complex permittivity features by applying electromagnetic fields to them and determining their complex permittivity features. That library of features is used to compare field measurements taken during an inspection to determine the presence of a material of interest and to identify it.
FILED	Monday, May 16, 2016
APPL NO	15/155866
ART UNIT	2896 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/00 (20130101) G01N 27/02 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 27/00 (20130101) G01R 33/16 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

10840078 — Enclosure for ion trapping device

US 10840078	Youngner et al.
FUNDED BY
APPLICANT(S)	Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)	Honeywell International Inc. (Charlotte, North Carolina)
INVENTOR(S)	Daniel Youngner (Maple Grove, Minnesota); Jason Simmons (Elk River, Minnesota); Thomas Ohnstein (Roseville, Minnesota); Jay Gordon Schwitchtenberg (New Hope, Minnesota)
ABSTRACT	Devices, methods, and systems for enclosures for an ion trapping device are described herein. One enclosure for an ion trapping device includes a heat spreader base that includes a perimeter portion and a center portion connected to the perimeter portion by a bridge portion, a grid array coupled to the heat spreader, a spacer with a plurality of studs coupled to the grid array, an interposer and ion trap die coupled to the spacer, a connector coupled to interposer, and a roof portion coupled to the heat spreader base.
FILED	Friday, September 13, 2019
APPL NO	16/570726
ART UNIT	2881 — Optics
CURRENT CPC	Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) H01J 49/24 (20130101) H01J 49/422 (20130101) Original (OR) Class H01J 49/0468 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, November 17, 2020.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2020/fedinvent-patents-20201117.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

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