FedInvent Patent Applications

Patent Application Details for Thursday, June 10, 2021 

This page was updated on Saturday, July 17, 2021 at 01:39 AM GMT

Department of Health and Human Services (HHS) 

US 20210169321 FINK et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) WOLFGANG FINK (TUCSON, Arizona);  MARK TARBELL (TUCSON, Arizona)
ABSTRACT Various examples of methods, systems and devices are provided for ophthalmic examination. In one example, a handheld system includes an optical imaging assembly coupled to a user device that includes a camera aligned with optics of the optical imaging assembly. The user device can obtain ocular imaging data of at least a portion of an eye via the optics of the optical imaging assembly and provide ophthalmic evaluation results based at least in part upon the ocular imaging data. In another example, a method includes receiving ocular imaging data of at least a portion of an eye; analyzing the ocular imaging data to determine at least one ophthalmic characteristic of the eye; and determining a condition based at least in part upon the at least one ophthalmic characteristic.
FILED Monday, November 23, 2020
APPL NO 17/101503
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 3/0008 (20130101)
A61B 3/12 (20130101) Original (OR) Class
A61B 3/14 (20130101)
A61B 3/0033 (20130101)
A61B 3/0041 (20130101)
A61B 3/135 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169334 Kodandaramaiah et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Suhasa Kodandaramaiah (Minneapolis, Minnesota);  Leila Ghanbari (Minneapolis, Minnesota);  Daniel Sousa Schulman (Minneapolis, Minnesota);  Michael Cary McAlpine (Minneapolis, Minnesota)
ABSTRACT A system and method is provided for imaging and monitoring a tissue, such as a cerebral cortex, of a subject. Access to imaging a tissue, such as cerebral cortex, may be provided by removing a portion of a bone, such as a portion of a skull of the subject. A prosthesis, such as an optically transparent prosthesis, may be used to replace the portion of the skull removed and may be conformed to the same 3D contour of the bone that was removed. A data acquisition system, such as an imaging system, may then be affixed to the skull prosthesis and may be used to acquire image data of the tissue of the subject at high spatial and temporal resolution and without interference from intervening bone material.
FILED Friday, December 04, 2020
APPL NO 17/111942
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/37 (20210101)
A61B 5/0071 (20130101) Original (OR) Class
A61B 5/6879 (20130101)
A61B 5/14546 (20130101)
A61B 5/14553 (20130101)
A61B 2562/046 (20130101)

Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/2875 (20130101)
A61F 2002/30985 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169336 Sanchez et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) ENSPECTRA HEALTH, INC. (Mountain View, California)
ASSIGNEE(S)
INVENTOR(S) Gabriel Sanchez (Menlo Park, California);  Fred Landavazo, IV (Redwood City, California);  Kathryn Montgomery (Mountain View, California);  Piyush Arora (San Carlos, California)
ABSTRACT The present disclosure provides methods and systems for identifying a tissue characteristic in a subject. Identifying a tissue characteristic may comprise accessing a database comprising a first set of data from a first image obtained from a first tissue region of the subject and a second set of data from a second image obtained from a second tissue region of the subject; computer processing the first set of data and the second set of data to (i) identify a presence or absence of one or more features indicative of the tissue characteristic in the first image, and (ii) classify the subject as being positive or negative for the tissue characteristic based on the presence or absence of the one or more features in the first image; and generating an electronic report which is indicative of the subject being positive or negative for the tissue characteristic.
FILED Thursday, November 12, 2020
APPL NO 17/096602
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0022 (20130101)
A61B 5/0066 (20130101)
A61B 5/0068 (20130101)
A61B 5/0071 (20130101)
A61B 5/0075 (20130101)
A61B 5/0077 (20130101) Original (OR) Class
A61B 5/444 (20130101)
A61B 5/445 (20130101)
A61B 5/7264 (20130101)
A61B 2562/028 (20130101)
A61B 2562/0242 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169349 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  Louis Stokes Cleveland Veterans Administration Medical Center (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Nathaniel Braman (Bethel Park, Pennsylvania)
ABSTRACT Embodiments discussed herein facilitate determination of a response to treatment and/or a prognosis for a tumor based at least in part on features of tumor-associated vasculature (TAV). One example embodiment is a method, comprising: accessing a medical imaging scan of a tumor, wherein the tumor is segmented on the medical imaging scan; segmenting tumor-associated vasculature (TAV) associated with the tumor based on the medical imaging scan; extracting one or more features from the TAV; providing the one or more features extracted from the TAV to a trained machine learning model; and receiving, from the machine learning model, one of a predicted response to a treatment for the tumor or a prognosis for the tumor.
FILED Wednesday, December 09, 2020
APPL NO 17/116319
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/004 (20130101)
A61B 5/08 (20130101)
A61B 5/0035 (20130101)
A61B 5/02007 (20130101) Original (OR) Class
A61B 5/7267 (20130101)
A61B 5/7275 (20130101)
A61B 6/481 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 7/12 (20170101)
G06T 2207/10081 (20130101)
G06T 2207/10088 (20130101)
G06T 2207/20036 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/30061 (20130101)
G06T 2207/30068 (20130101)
G06T 2207/30096 (20130101)
G06T 2207/30101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169400 Fan et al.
FUNDED BY
Department of Health and Human Services (HHS)
Assistant Secretary for Preparedness and Response (ASPR)
Biomedical Advanced Research and Development Authority (BARDA)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) SPECTRAL MD, INC. (Dallas, Texas)
ASSIGNEE(S)
INVENTOR(S) Wensheng Fan (Plano, Texas);  John Michael DiMaio (Dallas, Texas);  Jeffrey Thatcher (Irving, Texas)
ABSTRACT Certain aspects relate to apparatuses and techniques for non-invasive and non-contact optical imaging that acquires a plurality of images corresponding to both different times and different frequencies. Additionally, alternatives described herein are used with a variety of tissue classification applications including assessing the presence and severity of tissue conditions, such as necrosis and small vessel disease, at a potential or determined amputation site.
FILED Monday, August 24, 2020
APPL NO 17/000810
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0077 (20130101)
A61B 5/443 (20130101)
A61B 5/445 (20130101) Original (OR) Class
A61B 5/02007 (20130101)
A61B 5/7267 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6202 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169414 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Lihong Wang (Pasadena, California);  Konstantin Maslov (Pasadena, California);  Methodius Tuuli (St. Louis, Missouri);  Molly Stout (St. Louis, Missouri);  George Macones (St. Louis, Missouri);  Junhui Shi (Pasadena, California);  Peinan Zhao (St. Louis, Missouri);  Yuan Qu (St. Louis, Missouri);  Peng Hu (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri);  California Institute of Technology (Pasadena, California)
INVENTOR(S) Lihong Wang (Pasadena, California);  Konstantin Maslov (Pasadena, California);  Methodius Tuuli (St. Louis, Missouri);  Molly Stout (St. Louis, Missouri);  George Macones (St. Louis, Missouri);  Junhui Shi (Pasadena, California);  Peinan Zhao (St. Louis, Missouri);  Yuan Qu (St. Louis, Missouri);  Peng Hu (St. Louis, Missouri)
ABSTRACT In various aspects, a photoacoustic endoscopic probe and methods for measuring a hydration of a connective tissue in vivo using the photoacoustic endoscopic probe are disclosed.
FILED Thursday, December 03, 2020
APPL NO 17/110824
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/07 (20130101)
A61B 1/00096 (20130101)
A61B 1/00172 (20130101)
A61B 1/0638 (20130101)
A61B 5/0095 (20130101)
A61B 5/4875 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169431 BOONE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) John M. BOONE (Folsom, California);  Thomas R. YELLEN-NELSON (Del Mar, California)
ABSTRACT A device and methods for performing a simulated CT biopsy on a region of interest on a patient. The device comprises a gantry (22) configured to mount an x-ray emitter (24) and CT detector (26) on opposing sides of the gantry, a motor (28) rotatably coupled to the gantry such that the gantry rotates horizontally about the region of interest, and a rotation of source high resolution x-ray detector (172) positioned adjacent the CT detector in between the CT detector and the x-ray emitter.
FILED Friday, February 19, 2021
APPL NO 17/180549
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 6/03 (20130101)
A61B 6/12 (20130101)
A61B 6/037 (20130101)
A61B 6/405 (20130101)
A61B 6/0435 (20130101)
A61B 6/482 (20130101) Original (OR) Class
A61B 6/502 (20130101)
A61B 6/584 (20130101)
A61B 6/4028 (20130101)
A61B 6/4417 (20130101)
A61B 6/4423 (20130101)
A61B 6/5235 (20130101)
A61B 8/0825 (20130101)
A61B 8/4416 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169767 Xu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) X.Z. Shawn Xu (Ann Arbor, Michigan);  Jianfeng Liu (Wuhan, China PRC)
ABSTRACT The present disclosure relates to compositions capable of absorbing UVA and UVB light. In particle, the present disclosure relates to UV screening compositions comprising at least a portion of LITE-1 polypeptides which are capable of absorbing UV light (e.g., UV-A and/or UV-B light).
FILED Tuesday, December 15, 2020
APPL NO 17/122358
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 8/64 (20130101) Original (OR) Class
A61K 9/0014 (20130101)
A61K 38/1767 (20130101)
A61K 2800/10 (20130101)
A61K 2800/86 (20130101)

Specific Use of Cosmetics or Similar Toilet Preparations
A61Q 17/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169814 Felton et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Linda A. Felton (Albuquerque, New Mexico);  Pavan Muttil (Albuquerque, New Mexico)
ABSTRACT A pharmaceutical composition generally includes a primary microparticle having at least one drug dispersed within a matrix and a taste masking seal coating dispersed over at least a portion of the primary microparticle. In some embodiments, the seal coating can include a reverse enteric coating. In other embodiments, the seal coating can include a water-soluble polymer such as carrageenan, hypromellose, or polyvinyl alcohol. In some embodiments, the seal coating is continuous. In other embodiments, the seal coating is discontinuous. The pharmaceutical composition can be prepared using a two-step spray drying process.
FILED Friday, December 04, 2020
APPL NO 17/111645
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5026 (20130101)
A61K 9/5036 (20130101)
A61K 9/5047 (20130101)
A61K 9/5073 (20130101) Original (OR) Class
A61K 9/5089 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169846 SMITH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE TEXAS A and M UNIVERSITY SYSTEM (COLLEGE STATION, Texas);  SANO CHEMICALS (BRYAN, Texas)
ASSIGNEE(S)
INVENTOR(S) JAMES L. SMITH (BRYAN, Texas);  MENGXIN GENG (BEIJING, China PRC);  AKSHAYA RAVICHANDRAN (PALM BEACH GARDENS, Florida);  RAVI ORUGUNTY (ROUND ROCK, Texas)
ABSTRACT The subject invention pertains to methods for producing novel occidiofungin analogues lacking xylose (OF-Δxyl analogue). OF-Δxyl analogues can contain aldehyde, amine, triazole, or hydrazones. The aldehyde, amine, triazole or hydrazone containing analogues of OF-Δxyl can be further modified by substitution with additional functional groups. Various OF-Δxyl analogues described herein have reduced inflammation and toxicity and superior pharmacological properties compared to the natural occidiofungins. Accordingly, certain embodiments of the invention provide methods of treating or preventing fungal infections by administering to the subjects in need thereof the OF-Δxyl analogues described herein.
FILED Friday, April 05, 2019
APPL NO 17/045283
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/395 (20130101) Original (OR) Class
A61K 38/12 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 43/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169875 Laberge et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Buck Institute for Research on Aging (Novato, California);  Unity Biotechnology, Inc. (South San Francisco, California);  Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Remi-Martin Laberge (San Francisco, California);  Judith Campisi (Berkeley, California);  Albert Davalos (San Rafael, California);  Marco Demaria (Groningen, Netherlands);  Nathaniel David (Brisbane, California);  Jan M.A. van Deursen (Rochester, Minnesota);  Darren J. Baker (Rochester, Minnesota);  Bennett G. Childs (Rochester, Minnesota)
ABSTRACT Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
FILED Monday, December 07, 2020
APPL NO 17/114376
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0048 (20130101)
A61K 9/0073 (20130101)
A61K 31/404 (20130101)
A61K 31/428 (20130101)
A61K 31/495 (20130101)
A61K 31/496 (20130101) Original (OR) Class
A61K 31/728 (20130101)
A61K 31/4178 (20130101)
A61K 31/4375 (20130101)
A61K 31/5377 (20130101)
A61K 45/06 (20130101)
A61K 47/36 (20130101)
A61K 47/6807 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/10 (20180101)
A61P 11/00 (20180101)
A61P 25/28 (20180101)
A61P 27/02 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0081 (20130101)
C12N 15/113 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/485 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169876 Laberge et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Buck Institute for Research on Aging (Novato, California);  Unity Biotechnology, Inc. (South San Francisco, California);  Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Remi-Martin Laberge (San Francisco, California);  Judith Campisi (Berkeley, California);  Marco Demaria (Groningen, Netherlands);  Nathaniel David (Brisbane, California);  James L. Kirkland (Rochester, Minnesota);  Tamar Tchkonia (Rochester, Minnesota);  Yi Zhu (Rochester, Minnesota)
ABSTRACT Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
FILED Monday, December 07, 2020
APPL NO 17/114379
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0048 (20130101)
A61K 9/0073 (20130101)
A61K 31/404 (20130101)
A61K 31/428 (20130101)
A61K 31/495 (20130101)
A61K 31/496 (20130101) Original (OR) Class
A61K 31/728 (20130101)
A61K 31/4178 (20130101)
A61K 31/4375 (20130101)
A61K 31/5377 (20130101)
A61K 45/06 (20130101)
A61K 47/36 (20130101)
A61K 47/6807 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/10 (20180101)
A61P 11/00 (20180101)
A61P 25/28 (20180101)
A61P 27/02 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0081 (20130101)
C12N 15/113 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/485 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169883 Flanigan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) Icahn School of Medicine at Mount Sinai (New York, New York)
ASSIGNEE(S) Icahn School of Medicine at Mount Sinai (New York, New York)
INVENTOR(S) Meghan Flanigan (Chapel Hill, North Carolina);  Scott Russo (Pelham Manor, New York)
ABSTRACT The present invention provides orexin receptor antagonists for use in treating aggression in a subject. The orexin receptor antagonists can have selective affinity for orexin receptor 1 (Ox1R) or for orexin receptor 2 (Ox2). The orexin receptor antagonists can also have dual affinity for both Ox1R and Ox2R, wherein their affinities can be the same or different. The present invention also provides pharmaceutical compositions and kits comprising orexin receptor antagonists for treating aggression or for treating psychiatric disorders with an aggression component.
FILED Thursday, July 25, 2019
APPL NO 17/263488
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0056 (20130101)
A61K 31/36 (20130101)
A61K 31/444 (20130101)
A61K 31/472 (20130101)
A61K 31/506 (20130101) Original (OR) Class
A61K 31/551 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169904 AVRAM et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Dorina AVRAM (Tampa, Florida);  Benjamin George KESELOWSKY (Gainesville, Florida);  Joshua STEWART (Gainesville, Florida);  Jonathan Joseph CHO (Gainesville, Florida)
ABSTRACT Provided are a dual microparticle system to treat Multiple Sclerosis, the system comprising phagocytosable and non-phagocytosable microparticles for delivery of at least one antigen, at least one immunomodulatory agent, at least one immunosuppressive agent and at least one chemoattractant to a subject suffering from Multiple Sclerosis to generate tolerogenic dendritic cells in the subject and treat the Multiple Sclerosis.
FILED Wednesday, July 03, 2019
APPL NO 17/257731
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/203 (20130101)
A61K 31/436 (20130101)
A61K 31/593 (20130101) Original (OR) Class
A61K 38/193 (20130101)
A61K 38/1841 (20130101)
A61K 38/1866 (20130101)
A61K 38/2066 (20130101)
A61K 47/593 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169911 Jacobson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland);  University of Bonn (Bonn, Germany);  University of Münster (Münster, Germany)
ASSIGNEE(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland);  University of Bonn (Bonn, Germany);  University of Münster (Münster, Germany)
INVENTOR(S) Kenneth A. Jacobson (Silver Spring, Maryland);  Anna Junker (Senden, Germany);  Mirko Scortichini (Rockville, Maryland);  Clemens Dobelmann (Münster, Germany);  Christian P. Renn (Bonn, Germany);  Vigneshwaran Namasivayam (Bonn, Germany);  Riham Mohammed Idris (Bad Neuenar-Ahrweiler, Germany);  Christa E. Müller (Bonn, Germany)
ABSTRACT Disclosed is a compound of formula (I), wherein Q, U, T, A, a, b, c, and n are as defined herein. Also disclosed are methods of inhibiting ecto-5′-nucleotidase, inhibiting suppression of an antitumor immune response, inhibiting tumor growth of a cancerous tumor, inhibiting metastasis of cancer in a mammal afflicted with cancer, synergistically enhancing a response of a mammal afflicted with cancer undergoing treatment with an immunotherapeutic anti-cancer agent, potentiating an activity of an inhibitor of nicotinamide phosphoribosyltransferase in a mammal undergoing treatment of a mammal with the inhibitor, and treating preeclampsia in a mammal in need thereof, comprising administering to an animal an effective amount of a compound of formula (I).
FILED Friday, August 16, 2019
APPL NO 17/269094
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7068 (20130101) Original (OR) Class
A61K 39/3955 (20130101)
A61K 49/0021 (20130101)
A61K 49/0028 (20130101)
A61K 49/0036 (20130101)
A61K 49/0041 (20130101)
A61K 49/0052 (20130101)
A61K 51/0491 (20130101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 19/10 (20130101)
C07H 19/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169913 Davis et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE UAB RESEARCH FOUNDATION (Birmingham, Alabama);  Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Randall S. Davis (Birmingham, Alabama);  Daniel M. Schreeder (Huntsville, Alabama);  Douglas B. Johnson (Nashville, Tennessee);  Justin M. Balko (Nashville, Tennessee)
ABSTRACT Provided herein are methods for treating and preventing PD-1-mediated resistant cancers.
FILED Friday, November 09, 2018
APPL NO 16/762682
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101) Original (OR) Class
A61K 45/06 (20130101)
A61K 2039/505 (20130101)

Peptides
C07K 16/2818 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169914 DONNELLY et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania);  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Christopher DONNELLY (Pittsburgh, Pennsylvania);  Jacob MANN (Pittsburgh, Pennsylvania);  James SHORTER (Philadelphia, Pennsylvania);  Lin GUO (Philadelphia, Pennsylvania);  Bede PORTZ (Philadelphia, Pennsylvania)
ABSTRACT Disclosed herein are methods to treat a neurodegenerative disease comprising administering to a subject with a neurodegenerative disease a therapeutically effective amount of a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease. Also disclosed are methods to inhibit protein aggregation in a cell comprising contacting the cell with a composition comprising a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease. Additionally disclosed are compositions comprising a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease.
FILED Friday, August 16, 2019
APPL NO 17/268654
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169916 Bennett et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Ionis Pharmaceuticals, Inc. (Carlsbad, California);  Ludwing Institute for Cancer Research (Zurich, Switzerland)
ASSIGNEE(S) Ionis Pharmaceuticals, Inc. (Carlsbad, California);  Ludwig Institute for Cancer Research (Zurich, Switzerland)
INVENTOR(S) C. Frank Bennett (Carlsbad, California);  Frank Rigo (Carlsbad, California);  Don W. Cleveland (La Jolla, California);  Jie Jiang (San Diego, California);  Qiang Zhu (San Diego, California);  Clotilde Lagier-Tourene (Winchester, Massachusetts)
ABSTRACT Provided are methods for reducing the amount or activity of C9ORF72 RNA, and in certain instances of reducing the amount of C9ORF72 protein, in an animal. Such methods are useful to prevent or ameliorate at least one symptom of a neurodegenerative disease. Such symptoms include anxiety, reduced spatial learning, and memory loss. Such neurodegenerative diseases include amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), corticalbasal degeneration syndrome (CBD), atypical Parkinsonian syndrome, and olivopontocerellar degeneration (OPCD).
FILED Thursday, July 23, 2020
APPL NO 16/937386
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/712 (20130101) Original (OR) Class
A61K 31/7105 (20130101)
A61K 31/7115 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)
C12N 2310/11 (20130101)
C12N 2310/315 (20130101)
C12N 2310/341 (20130101)
C12N 2310/345 (20130101)
C12N 2310/3233 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169920 Yin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) University of Georgia Research Foundation, Inc. (Athens, Georgia)
ASSIGNEE(S)
INVENTOR(S) Hang Yin (Watkinsville, Georgia);  Liwei Xie (Athens, Georgia);  Amelia Yao-Ye Yin (Watkinsville, Georgia)
ABSTRACT Compositions and methods for modulating HIF-2α to meditate of hypoxia signaling in satellite cells and applications thereof for improving skeletal muscle generation and repair are provided. For example, methods of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof are disclosed. In some embodiments, the methods include administering the subject an effective amount of HIF-2α inhibitor. The HIF-2α inhibitor can be effective to, for example, increase muscle satellite cell proliferation, differentiation, or a combination thereof in a subject. Composition and methods for improving respiration, and reducing or preventing the development or progression of fibrosis are also provided. The disclosed compositions and methods are particularly useful for treating muscular dystrophies, myopathies, and other muscle-related diseases and disorders.
FILED Monday, February 22, 2021
APPL NO 17/181921
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 31/015 (20130101)
A61K 31/277 (20130101)
A61K 31/7105 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/04 (20180101)
A61P 25/14 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6876 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169941 Hasty et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Jeff Hasty (Encinitas, California);  Michael Julius Liao (San Diego, California);  Muhammad Omar Din (San Diego, California)
ABSTRACT Provided herein are multi-strain population control systems, methods, kits, and compositions. Also provided are methods, systems, kits, and compositions for culturing bacterial cells in multi-strain ecosystems, and temporally arranged multi-strain ecosystems or cultures using a synchronized lysis circuit in combination with multiple toxin/antitoxin systems to cycle continuously over a long period of time.
FILED Friday, June 07, 2019
APPL NO 16/972405
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/74 (20130101) Original (OR) Class
A61K 2035/115 (20130101)

Peptides
C07K 14/245 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169943 MYLES et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) US Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) Ian Antheni MYLES (Bethesda, Maryland);  Sandip K. DATTA (Bethesda, Maryland)
ABSTRACT Pharmaceutical compositions are disclosed that includes a therapeutically effective amount of a purified viable Gram negative bacteria and a pharmaceutically acceptable carrier. The pharmaceutical compositions are formulated for topical administration. Methods of treating atopic dermatitis using these pharmaceutical compositions are also disclosed.
FILED Monday, January 25, 2021
APPL NO 17/157761
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 9/0014 (20130101)
A61K 35/74 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 17/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169954 Balani et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) Forsyth Dental Infirmary for Children (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Pooja Balani (Melrose, Massachusetts);  Felicitas Bidlack (Somerville, Massachusetts);  Xuesong He (Cypress, California);  Megan Pugach-Gordon (Medford, Massachusetts);  Wenyuan Shi (Boston, Massachusetts);  Jacqueline Starr (Lexington, Massachusetts);  Daniel Ferrer (Boston, Massachusetts)
ABSTRACT Provided herein are methods and compositions related to bacteria of genus Rothia useful as therapeutic agents for dental caries.
FILED Friday, December 11, 2020
APPL NO 17/119933
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 6/00 (20130101)
A61K 35/747 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169966 PEI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Dehua PEI (Columbus, Ohio);  John W. CHRISTMAN (Columbus, Ohio);  Manjula KARPURAPU (Columbus, Ohio);  Patrick G. DOUGHERTY (Columbus, Ohio)
ABSTRACT Described are peptides and peptide conjugates comprising CN binding motifs (CNBM) which inhibit the CN-NFAT interaction. In some embodiments, the peptides comprise: (i) CNBM; (ii) a hydrophobic, non-peptidic moiety (RH) which interacts with the hydrophobic pocket on a CN protein; (iii) a sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-, wherein each of AAU2, AAU3, AAU4, AAU5, and AAU6, is, independently, optional, and each of AAU, AAU2, AAU3, AAU4, AAU5, and AAU6 when present is independently an amino acid as defined herein; or (iv) combinations thereof. In some embodiments, RH is conjugated to the N- or C-terminus of the CNBM. In some embodiments, the sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6- is conjugated to the N- or C terminus of the CNBM. In some embodiments, the peptides comprise: CNBM and RH. In some embodiments. In some embodiments, the peptides comprise: CNBM and AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-. In some embodiments, the peptides of the disclosure CNBM and RH.
FILED Tuesday, January 29, 2019
APPL NO 16/965718
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/08 (20130101) Original (OR) Class
A61K 47/64 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 11/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169984 Lee et al.
FUNDED BY
Department of Defense (DOD)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Seulki Lee (Elkridge, Maryland);  Martin Pomper (Baltimore, Maryland);  Yumin Oh (Elkridge, Maryland);  Magdalena Scully (Mount Airy, Maryland)
ABSTRACT The present invention relates to methods for sensitizing cancers to death receptor agonist therapies, comprising use of one or more kinase inhibitors. Such kinase inhibitors can be administered and identified as effective for sensitizing to death receptor agonist therapy in vitro or in vivo. Screening for additional kinase inhibitors and other agents that sensitize cancer cells to death receptor agonists is also contemplated, as is preventing and/or treatment of cancer using combination therapies that include such agents (e.g., kinase inhibitor(s) and death receptor agonist(s)). Formulations and kits including such combined agents are also contemplated and described, as are diagnostic/imaging agents that allow for advanced tracking of therapeutic outcome.
FILED Thursday, January 19, 2017
APPL NO 16/071116
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/20 (20130101)
A61K 9/0053 (20130101)
A61K 31/44 (20130101)
A61K 31/52 (20130101)
A61K 31/53 (20130101)
A61K 31/194 (20130101)
A61K 31/277 (20130101)
A61K 31/352 (20130101)
A61K 31/404 (20130101)
A61K 31/437 (20130101)
A61K 31/444 (20130101)
A61K 31/453 (20130101)
A61K 31/454 (20130101)
A61K 31/496 (20130101)
A61K 31/506 (20130101)
A61K 31/517 (20130101)
A61K 31/519 (20130101)
A61K 31/4439 (20130101)
A61K 31/4465 (20130101)
A61K 31/4706 (20130101)
A61K 31/4709 (20130101)
A61K 31/4745 (20130101)
A61K 31/4985 (20130101)
A61K 31/5025 (20130101)
A61K 31/5377 (20130101)
A61K 38/191 (20130101) Original (OR) Class
A61K 47/60 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5011 (20130101)
G01N 2333/912 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169990 Sullivan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Schepens Eye Research Institute (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Benjamin Sullivan (San Diego, California);  Tannin A. Schmidt (Calgary, Canada);  David A. Sullivan (Boston, Massachusetts)
ABSTRACT The present invention provides a pharmaceutical composition, and methods of use thereof, for treating ocular boundary deficiency, symptoms associated therewith, or an undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface. The pharmaceutical composition of the present invention comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The pharmaceutical composition of the present invention may also comprise one or more ophthalmically acceptable agents selected from the group consisting of an ophthalmically acceptable demulcent, excipient, astringent, vasoconstrictor, emollient, sodium hyaluronate, hyaluronic acid, and surface active phospholipids, in a pharmaceutically acceptable carrier for topical administration.
FILED Thursday, May 23, 2019
APPL NO 16/420361
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/08 (20130101)
A61K 9/0048 (20130101)
A61K 31/728 (20130101)
A61K 38/39 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170001 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) City of Hope (Duarte, California)
ASSIGNEE(S)
INVENTOR(S) Xiuli Wang (Duarte, California);  Stephen J. Forman (Duarte, California)
ABSTRACT Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.
FILED Thursday, August 13, 2020
APPL NO 16/992361
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)
A61K 39/0011 (20130101) Original (OR) Class
A61K 2039/5156 (20130101)
A61K 2039/5158 (20130101)

Peptides
C07K 14/35 (20130101)
C07K 14/71 (20130101)
C07K 14/705 (20130101)
C07K 14/7051 (20130101)
C07K 14/70521 (20130101)
C07K 16/2803 (20130101)
C07K 16/2896 (20130101)
C07K 2317/53 (20130101)
C07K 2317/526 (20130101)
C07K 2317/622 (20130101)
C07K 2319/02 (20130101)
C07K 2319/03 (20130101)
C07K 2319/033 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
C12N 5/0637 (20130101)
C12N 5/0638 (20130101)
C12N 2510/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170004 Bae et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Jooeun Bae (West Roxbury, Massachusetts);  Nikhil Munshi (Needham, Massachusetts);  Kenneth Anderson (Wellesley, Massachusetts)
ABSTRACT The disclosure features, inter alia, immunogenic XBP1-, CD138-, and CS1-derived peptides (and pharmaceutical compositions thereof). The peptides can be used in a variety of methods such as methods for inducing an immune response, methods for producing an antibody, and methods for treating a cancer (e.g., breast cancer, colon cancer, pancreatic cancer, a blood cancer, e.g., leukemia or a plasma cell disorder such as multiple myeloma or Waldenstrom's macroglobulinemia). The peptides (and pharmaceutical compositions comprising the peptides) can be used, e.g., in a method of treating a precancerous condition such as smoldering multiple myeloma. The peptides can also be included in MHC molecule multimer compositions and used in, e.g., methods for detecting a T cell in a population of cells.
FILED Wednesday, February 10, 2021
APPL NO 17/172805
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/193 (20130101)
A61K 38/1709 (20130101)
A61K 38/1774 (20130101)
A61K 39/0011 (20130101)
A61K 39/39 (20130101)
A61K 39/001152 (20180801) Original (OR) Class
A61K 39/39558 (20130101)
A61K 45/06 (20130101)
A61K 2039/505 (20130101)
A61K 2039/55511 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170005 Sayour et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Elias Sayour (Gainesville, Florida);  Duane Mitchell (Gainesville, Florida)
ABSTRACT The present disclosure provides methods of increasing sensitivity of a tumor to treatment with an immune checkpoint inhibitor (ICI) in a subject and methods of treating a subject with an immune checkpoint inhibitor (ICI)-resistant tumor. The methods comprise administering to the subject a composition comprising a liposome comprising a cationic lipid and mRNA molecules, wherein the liposome is systemically administered to the subject. Also provided are methods of increasing the number of activated plasmacytoid dendritic cells (pDCs) in a subject in need thereof, comprising administering to the subject a composition comprising a liposome comprising a cationic lipid and mRNA molecules, wherein the liposome is systemically administered to the subject. Combination therapy with anti-PD-L1 mAb. Related methods of treatment and methods of preparing a dendritic cell vaccine are additionally provided.
FILED Thursday, August 15, 2019
APPL NO 17/268408
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/127 (20130101)
A61K 35/15 (20130101)
A61K 39/001193 (20180801) Original (OR) Class
A61K 39/3955 (20130101)
A61K 47/186 (20130101)
A61K 47/6911 (20170801)
A61K 2039/53 (20130101)
A61K 2039/54 (20130101)
A61K 2039/5154 (20130101)
A61K 2039/55555 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0639 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170008 JACOBS, JR. et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Albert Einstein College of Medicine (Bronx, New York)
ASSIGNEE(S)
INVENTOR(S) William R. JACOBS, JR. (Pelham, New York);  Sangeeta TIWARI (Bronx, New York)
ABSTRACT Provided are attenuated strains of M. tuberculosis and M. bovis BCG which are double auxotrophic mutants with genes knocked out in the biosynthetic pathways for arginine and methionine, and compositions and methods of use thereof.
FILED Thursday, August 15, 2019
APPL NO 17/268789
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/04 (20130101) Original (OR) Class
A61K 2039/522 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 37/04 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/52 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6897 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170012 Nizet et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (, None)
INVENTOR(S) Victor Nizet (San Diego, California);  Nina van Sorge (Leusden, Netherlands)
ABSTRACT In alternative embodiments, the invention provides vaccines, pharmaceutical compounds and formulations for diagnosing, preventing, treating or ameliorating Group A Streptococcus (GAS), Group C Streptococcus (GCS), or Group A Streptococcus (GGS), infections, or other pathogenic Streptococcus infections. In alternative embodiments, the invention provides compositions such as diagnostic tests, assays, immunoassays and test strips, and methods, for detecting or diagnosing the presence of a Streptococcal infection, e.g., Group A Streptococcus (GAS), Group C Streptococcus (GCS), or Group A Streptococcus (GGS), infections, or other pathogenic Streptococcus infections.
FILED Tuesday, August 25, 2020
APPL NO 17/002337
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/092 (20130101) Original (OR) Class
A61K 2039/522 (20130101)

Peptides
C07K 14/315 (20130101)
C07K 16/44 (20130101)
C07K 16/1275 (20130101)

Polysaccharides; Derivatives Thereof
C08B 37/0006 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
C12N 1/36 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5308 (20130101)
G01N 33/56938 (20130101)
G01N 33/56944 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170014 Flavell et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Richard Flavell (Guilford, Connecticut);  Noah Palm (New Haven, Connecticut);  Marcel De Zoete (New Haven, Connecticut)
ABSTRACT The invention relates to compositions and methods for treating inflammatory diseases and disorders in a subject in need thereof. In certain aspects, the invention relates to immunogenic compositions (e.g., vaccines) to diminish the number or pathogenic effects of one or more bacteria associated with the development or progression of an inflammatory disease or disorder.
FILED Thursday, February 18, 2021
APPL NO 17/178412
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0053 (20130101)
A61K 39/0008 (20130101)
A61K 39/39 (20130101)
A61K 39/116 (20130101) Original (OR) Class
A61K 2039/58 (20130101)
A61K 2039/577 (20130101)
A61K 2039/55544 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 29/00 (20180101)
A61P 31/04 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170015 Arts et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Eric J. Arts (Ontario, Canada);  Jamie Mann (Ontario, Canada)
ABSTRACT A method of reducing a latent HIV-specific memory-CD4+ T cell pool in a subject includes administering to the subject at least one HIV-1 protein and a pharmaceutically acceptable carrier, wherein the at least one HIV-1 protein is derived from an allogenic infecting HIV-1 virus, and wherein the HIV-1 protein stimulates latent HIV-specific memory CD4+ T cells to induce latent HIV-1 replication resulting in HIV-specific memory-CD4+ T cell death in the subject.
FILED Tuesday, December 08, 2020
APPL NO 17/115355
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101) Original (OR) Class
A61K 39/39 (20130101)
A61K 45/06 (20130101)
A61K 2039/572 (20130101)
A61K 2039/6075 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/18 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2740/16034 (20130101)
C12N 2740/16134 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170019 CUI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Zhengrong CUI (Austin, Texas);  Sachin G. THAKKAR (Austin, Texas)
ABSTRACT Described herein are dry immunogenic compositions and methods of freezing aluminum-containing vaccines such that when converted into a dried powder, the dry composition can be readily administered without loss of activity. Also described are methods of intranasal administering dry immunogenic compositions comprising antigens and aluminum adjuvants.
FILED Tuesday, December 11, 2018
APPL NO 16/771648
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/02 (20130101)
A61K 39/12 (20130101)
A61K 39/39 (20130101) Original (OR) Class
A61K 2039/55505 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170051 Gray et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Steven James Gray (Southlake, Texas);  Sarah Sinnett (Farmers Branch, Texas)
ABSTRACT This invention relates to feedback-enabled synthetic genes, polynucleotide target cassettes, vectors, and pharmaceutical compositions for the purpose of providing transgene expression in target tissues that is capable of endogenous regulation for treating disorders such as dose-sensitive intellectual ability disorders, as well as methods of making and methods of using the same.
FILED Thursday, August 29, 2019
APPL NO 17/271432
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/005 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Peptides
C07K 14/4703 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170052 Klinghoffer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Presage Biosciences, Inc. (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Richard Klinghoffer (Seattle, Washington);  Jason Frazier (Seattle, Washington);  Marc Grenley (Seattle, Washington)
ABSTRACT An administration device comprising an array of needles, one or more fluid agents, and at least one hydrogel is described. The device can simultaneously deliver a plurality of fluid agents along respective axes into a tissue. The use of hydrogel leads to constrained delivery of the fluid agents. The constrained delivery of an agent is also achieved by depositing a drug implant into a tissue. The effect of an agent on the tissue can be evaluated thereafter. In addition, the invention is directed to treating muscle diseases by delivering a therapeutic agent in vivo, and the use of reporter tissues for candidate drug evaluation, detecting and characterizing resistance.
FILED Thursday, October 15, 2020
APPL NO 17/071707
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0004 (20130101) Original (OR) Class
A61K 49/0008 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/142 (20130101)
A61M 5/1408 (20130101)
A61M 5/3298 (20130101)
A61M 5/14212 (20130101)
A61M 37/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170055 Tanifum et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Child Health and Human Development (NICHD)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) Texas Children's Hospital (Houston, Texas)
ASSIGNEE(S) Texas Children's Hospital (Houston, Texas)
INVENTOR(S) Eric A. Tanifum (Richmond, Texas);  Ketankumar B. Ghaghada (Sugar Land, Texas);  Ananth V. Annapragada (Manvel, Texas)
ABSTRACT A liposomal composition (“ADx-001”) is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid.
FILED Friday, January 29, 2021
APPL NO 17/162338
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/10 (20130101)
A61K 49/0034 (20130101)
A61K 49/0084 (20130101)
A61K 49/126 (20130101)
A61K 49/1812 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170074 ANIKEEVA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Polina Olegovna ANIKEEVA (Somerville, Massachusetts);  Dena Shahriari (Boston, Massachusetts);  Yoel FINK (Brookline, Massachusetts);  Zi Jie Gabriel Loke (Cambridge, Massachusetts);  Ian James Tafel (Jamaica Plain, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Polina Olegovna ANIKEEVA (Somerville, Massachusetts);  Dena Shahriari (Boston, Massachusetts);  Yoel FINK (Brookline, Massachusetts);  Zi Jie Gabriel Loke (Cambridge, Massachusetts);  Ian James Tafel (Jamaica Plain, Massachusetts)
ABSTRACT Methods for generating porous scaffolds may include tuning a porogen/crystallite's particle size to a desired range and mixing the crystallite particles with a polymer solution. The mixture is then cast to form films. The films are rolled and consolidated around another inner material to create a preform, which is then thermally drawn. The inner material and the porogen can be selectively removed to obtain porous constructs/fibers. The structures can be fuse-printed to produce complex tissue scaffolds with dimensions up to several centimeters and beyond.
FILED Tuesday, November 26, 2019
APPL NO 16/695932
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/16 (20130101)
A61L 27/26 (20130101)
A61L 27/56 (20130101) Original (OR) Class
A61L 27/3675 (20130101)
A61L 27/3687 (20130101)
A61L 27/3691 (20130101)
A61L 2430/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170180 Dosenbach et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Nico Dosenbach (St. Louis, Missouri);  Chad Sylvester (St. Louis, Missouri);  Deanna Greene (St. Louis, Missouri);  Scott Marek (St. Louis, Missouri);  Scott Norris (St. Louis, Missouri);  Jarod Roland (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Nico Dosenbach (St. Louis, Missouri);  Chad Sylvester (St. Louis, Missouri);  Deanna Greene (St. Louis, Missouri);  Scott Marek (St. Louis, Missouri);  Scott Norris (St. Louis, Missouri);  Jarod Roland (St. Louis, Missouri)
ABSTRACT A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.
FILED Wednesday, December 09, 2020
APPL NO 17/116712
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0036 (20180801)
A61B 5/0042 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/3727 (20130101)
A61N 1/36189 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170201 Berbeco et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Ross Berbeco (Cohasset, Massachusetts);  Yue-Houng Hu (Rochester, Minnesota)
ABSTRACT Some aspects of the disclosure provide a radiation therapy system. The system can include a radiation source configured to emit a radiation therapy beam, a collimator positioned to attenuate at least a periphery of the radiation therapy beam, a radiation fiducial marker configured to be coupled to a patient, and a first radiation detector and a second radiation detector configured to receive the radiation therapy beam after passing through a patient. The system also includes a computer configured to determine a position of the radiation fiducial marker using information from the first detector and the second detector.
FILED Monday, December 07, 2020
APPL NO 17/114077
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 6/4266 (20130101)
A61B 90/39 (20160201)
A61B 2090/3937 (20160201)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/1045 (20130101)
A61N 5/1049 (20130101)
A61N 5/1077 (20130101) Original (OR) Class

Measurement of Nuclear or X-radiation
G01T 1/2018 (20130101)
G01T 1/2023 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170411 Sharei et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Armon R. Sharei (Cambridge, Massachusetts);  Viktor A. Adalsteinsson (Cambridge, Massachusetts);  Nahyun Cho (Closter, New Jersey);  Robert S. Langer (Newton, Massachusetts);  J. Christopher Love (Somerville, Massachusetts);  Klavs F. Jensen (Lexington, Massachusetts)
ABSTRACT Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.
FILED Tuesday, October 20, 2020
APPL NO 17/075116
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502761 (20130101) Original (OR) Class
B01L 2200/0652 (20130101)
B01L 2300/08 (20130101)
B01L 2400/0487 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0634 (20130101)
C12N 5/0693 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/04 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/30 (20130101)
G01N 15/1459 (20130101)
G01N 15/1484 (20130101)
G01N 33/574 (20130101)
G01N 2015/0065 (20130101)
G01N 2015/1006 (20130101)
G01N 2015/1081 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170423 DOBSON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Jon P. DOBSON (Gainesville, Florida);  Isaac Ernest Philip FINGER-BAKER (Gainesville, Florida)
ABSTRACT Embodiments of the present disclosure include separating devices and systems and methods of use. Embodiments of the present disclosure include separation devices including magnetic arrays and sheet-flow separation chambers. In an embodiment, the separating device enables the generation of multiple, and in some configurations, intersecting, high gradient magnetic field lines, resulting in strong separation forces, which permit for scale up to large areas and/or volumes (e.g., extracorporeal blood filtration system).
FILED Wednesday, November 14, 2018
APPL NO 16/763790
CURRENT CPC
Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields
B03C 1/01 (20130101)
B03C 1/002 (20130101) Original (OR) Class
B03C 1/288 (20130101)
B03C 1/0332 (20130101)
B03C 1/0335 (20130101)
B03C 2201/18 (20130101)
B03C 2201/22 (20130101)
B03C 2201/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171432 Verdin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The J. David Gladstone Institutes (San Francisco, California);  The Regents of the University of California (Oakland, California);  Ithaca College (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Eric Verdin (Mill Valley, California);  Scott Michael Ulrich (Brooktondale, New York);  John C. Newman (San Francisco, California)
ABSTRACT Aspects of the present disclosure include fatty acid β-hydroxyester compounds (e.g., fatty acid esters of β-hydroxybutyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid β-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described.
FILED Wednesday, December 02, 2020
APPL NO 17/110236
CURRENT CPC
Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 33/12 (20160801)

Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages
A23V 2002/00 (20130101)
A23V 2200/322 (20130101)
A23V 2250/54 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/23 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/10 (20180101)
A61P 13/12 (20180101)
A61P 25/08 (20180101)
A61P 25/16 (20180101)
A61P 25/28 (20180101)
A61P 35/00 (20180101)

Acyclic or Carbocyclic Compounds
C07C 69/34 (20130101) Original (OR) Class

Optical Elements, Systems, or Apparatus
G02B 1/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171454 Xie et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
INVENTOR(S) Xiang-Qun Xie (Sewickley, Pennsylvania);  Zhiwei Feng (Pittsburgh, Pennsylvania)
ABSTRACT Novel diphenylurea and benzylbenzenesulfonamide compounds are disclosed along with methods of inhibiting the activity of TRPV1 and methods of treating pain associated with transient receptor potential vanilloid type 1 (TRPV1) using such compounds
FILED Tuesday, November 24, 2020
APPL NO 17/103941
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 275/30 (20130101) Original (OR) Class
C07C 275/32 (20130101)
C07C 275/34 (20130101)
C07C 275/40 (20130101)
C07C 275/42 (20130101)

Heterocyclic Compounds
C07D 295/135 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171455 Sheppard et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Shanghai ChemPartner Co., Ltd. (South San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Dean Sheppard (Oakland, California);  William F. DeGrado (San Francisco, California);  Hyunil Jo (Lafayette, California);  Aparna Sundaram (San Francisco, California);  Richard Beresis (San Francisco, California)
ABSTRACT The disclosure provides, inter alia, alpha-5 beta-1 inhibitors, pharmaceutical compositions comprising alpha-5 beta-1 inhibitors, methods for treating diseases using alpha-5 beta-1 inhibitors, and processes for making alpha-5 beta-1 inhibitors.
FILED Wednesday, December 09, 2020
APPL NO 17/117004
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 279/18 (20130101) Original (OR) Class
C07C 279/28 (20130101)
C07C 317/14 (20130101)
C07C 2601/16 (20170501)

Heterocyclic Compounds
C07D 213/74 (20130101)
C07D 215/42 (20130101)
C07D 233/88 (20130101)
C07D 235/16 (20130101)
C07D 239/14 (20130101)
C07D 265/08 (20130101)
C07D 265/36 (20130101)
C07D 279/06 (20130101)
C07D 295/155 (20130101)
C07D 311/68 (20130101)
C07D 401/12 (20130101)
C07D 403/12 (20130101)
C07D 413/12 (20130101)
C07D 417/12 (20130101)
C07D 471/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171469 Capobianco et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF MIAMI (Miami, Florida)
ASSIGNEE(S)
INVENTOR(S) Anthony J. Capobianco (Miami Beach, Florida);  Stephan C. Schürer (Coral Gables, Florida);  Xiaoxia Zhu (Palmetto Bay, Florida);  Tanya T. Kelley (Miami, Florida)
ABSTRACT Disclosed herein are Notch transcriptional activation complex kinase (“NACK”) inhibitors, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein include compounds of Formula (la) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
FILED Wednesday, February 06, 2019
APPL NO 16/967652
CURRENT CPC
Heterocyclic Compounds
C07D 231/54 (20130101) Original (OR) Class

Enzymes
C12Y 207/00 (20130101)
C12Y 306/01003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171470 Crew et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Arvinas Operations, Inc. (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Andrew P. Crew (Guilford, Connecticut);  Keith R. Hornberger (Southbury, Connecticut);  Lawrence B. Snyder (Killingworth, Connecticut);  Kurt Zimmermann (Durham, Connecticut);  Jing Wang (Milford, Connecticut);  Michael Berlin (Flemington, New Jersey);  Craig M. Crews (New Haven, Connecticut);  Hanqing Dong (Madison, Connecticut)
ABSTRACT The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.
FILED Friday, May 29, 2020
APPL NO 16/888484
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/02 (20130101)
A61K 31/166 (20130101)
A61K 31/277 (20130101)
A61K 31/497 (20130101)
A61K 45/06 (20130101)
A61K 47/10 (20130101)

Heterocyclic Compounds
C07D 205/04 (20130101)
C07D 209/48 (20130101)
C07D 211/76 (20130101)
C07D 213/72 (20130101)
C07D 221/20 (20130101)
C07D 231/12 (20130101)
C07D 233/42 (20130101) Original (OR) Class
C07D 237/08 (20130101)
C07D 239/24 (20130101)
C07D 241/04 (20130101)
C07D 401/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171473 ARORA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Eye Institute (NEI)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Paramjit S. ARORA (Cold Spring Harbor, New York);  Brooke Bullock LAO (Leesville, South Carolina);  Richard BONNEAU (New York, New York);  Kevin DREW (Austin, Texas)
ABSTRACT The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
FILED Monday, August 03, 2020
APPL NO 16/984041
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 29/80 (20130101)
C07C 29/88 (20130101)

Heterocyclic Compounds
C07D 241/08 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171492 ZHAO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Crinetics Pharmaceuticals, Inc. (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) Jian ZHAO (San Diego, California);  Sangdon HAN (San Diego, California);  Sun Hee KIM (San Diego, California);  Shimiao WANG (San Diego, California);  Yunfei ZHU (San Diego, California)
ABSTRACT Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.
FILED Monday, October 26, 2020
APPL NO 17/080358
CURRENT CPC
Heterocyclic Compounds
C07D 401/04 (20130101) Original (OR) Class
C07D 401/14 (20130101)
C07D 405/14 (20130101)
C07D 413/14 (20130101)
C07D 471/04 (20130101)
C07D 498/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171497 HODGETTS et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Kevin HODGETTS (Boston, Massachusetts);  Chien-Liang Glenn LIN (Columbus, Ohio)
ABSTRACT Disclosed are compounds that activate excitatory amino acid transporter 2 (EAAT2), as well as methods of using these compounds to treat or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity.
FILED Tuesday, June 04, 2019
APPL NO 16/972311
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/22 (20180101)
A61P 25/24 (20180101)
A61P 25/28 (20180101)

Heterocyclic Compounds
C07D 237/14 (20130101)
C07D 401/04 (20130101)
C07D 401/14 (20130101) Original (OR) Class
C07D 413/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171521 Plewe et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Arisan Therapeutics, Inc. (San Diego, California)
ASSIGNEE(S) Arisan Therapeutics, Inc. (San Diego, California)
INVENTOR(S) Michael Bruno Plewe (San Diego, California);  Kenneth McCormack (Oceanside, California);  Gregory Henkel (Carlsbad, California);  Nadezda V. Sokolova (San Diego, California);  Eric Brown (Santee, California);  Vidyasagar Reddy Gantla (San Diego, California)
ABSTRACT The compounds of the invention as shown by general structure I, as shown below, are effective in treating filovirus infections.
    • X is selected from the group consisting of O and H;
    • R1 is selected from (C6 to C10) aryl and (C2 to C9) heteroaryl, and
    • R2 is selected from (C1 to C10) alkyl, (C1 to C10) alkenyl, (C1 to C10) alkynyl, (C3 to C10) cycloalkyl, and (C5 to C10) cycloalkenyl, and
    • NR3aR3b is defined in the specification.
These compounds are effective in treating filovirii infections including Ebolavirus and Marburg virus.
FILED Wednesday, July 11, 2018
APPL NO 16/629882
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Acyclic or Carbocyclic Compounds
C07C 235/40 (20130101)

Heterocyclic Compounds
C07D 205/12 (20130101)
C07D 209/54 (20130101)
C07D 211/58 (20130101)
C07D 295/192 (20130101)
C07D 471/08 (20130101)
C07D 471/10 (20130101) Original (OR) Class
C07D 487/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171562 Boons et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia)
ASSIGNEE(S)
INVENTOR(S) Geert-Jan Boons (Athens, Georgia);  Anthony Robert Prudden (Athens, Georgia);  Lin Liu (Athens, Georgia)
ABSTRACT Disclosed herein are oligosaccharides and intermediates useful for the production thereof. The compounds are useful as analytical standards and as intermediates for the preparation of more complex oligosaccharide and N-glycan products. The compounds may be prepared in high purity using the selective stop/go synthetic methods disclosed herein.
FILED Wednesday, December 09, 2020
APPL NO 17/116706
CURRENT CPC
Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 5/06 (20130101) Original (OR) Class

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 19/26 (20130101)
C12P 19/305 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171563 Kalas et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Vasilios Kalas (St. Louis, Missouri);  James W. Janetka (St. Louis, Missouri);  Scott Hultgren (St. Louis, Missouri);  Jerry Pinkner (St. Louis, Missouri);  Amarendar Maddirala (St. Louis, Missouri);  Vishnu Damalanka (St. Louis, Missouri)
ABSTRACT The present invention is directed to various compounds, compositions, and methods for treating bacterial infections such as urinary tract infections.
FILED Thursday, November 08, 2018
APPL NO 16/762724
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/706 (20130101)
A61K 31/7034 (20130101)
A61K 31/7048 (20130101)
A61K 31/7056 (20130101)
A61K 45/06 (20130101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 15/20 (20130101)
C07H 15/26 (20130101)
C07H 15/203 (20130101) Original (OR) Class
C07H 17/02 (20130101)
C07H 17/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171581 Lehrer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Hawaii (Honolulu, Hawaii)
ASSIGNEE(S)
INVENTOR(S) Axel Lehrer (Honolulu, Hawaii);  Saguna Verma (Honolulu, Hawaii)
ABSTRACT Provided herein are compositions that include an isolated glycosylated polypeptide comprising at least 50 amino acid residues of a surface glycoprotein of a filovirus and a pharmaceutically acceptable carrier. The glycosylated polypeptide corresponds to one or more structural subunits of the glycoprotein. When the compositions are administered to a subject, they stimulate an innate immune response. The response can be stimulated with administration in the absence of an adjuvant. Methods of using the compositions and for their production are also disclosed.
FILED Tuesday, May 15, 2018
APPL NO 16/613742
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 2039/70 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 14/005 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2760/14022 (20130101)
C12N 2760/14034 (20130101)
C12N 2760/14122 (20130101)
C12N 2760/14134 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171586 Bielicki et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Berkeley National Laboratory (LBNL)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) John K. Bielicki (San Ramon, California);  Jan Johansson (San Ramon, California);  Waleed Danho (Del Mar, California)
ABSTRACT The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer's Disease or frontotemporal dementia.
FILED Thursday, September 10, 2020
APPL NO 17/016541
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/17 (20130101)
A61K 45/06 (20130101)
A61K 47/64 (20170801)
A61K 47/544 (20170801)

Peptides
C07K 14/435 (20130101) Original (OR) Class
C07K 14/775 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171592 Song et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Wenchao Song (Bryn Mawr, Pennsylvania);  Damodar Gullipalli (Mount Laurel, New Jersey);  Takashi Miwa (Bala Cynwyd, Pennsylvania)
ABSTRACT A recombinant vector having an expression cassette comprising a modified human factor H (hfH) gene is provided, wherein said hfH gene encodes a hfH protein variant comprising SCR1-4, 19-20, and one or more of SCR7, SCR17 and/or SCR18. Also provided are pharmaceutical compositions containing this vector and uses therefor in treating AMD and/or other complement associated diseases.
FILED Friday, January 22, 2021
APPL NO 17/156023
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6911 (20170801)
A61K 48/00 (20130101)
A61K 48/005 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/04 (20180101)

Peptides
C07K 14/472 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101)
C12N 2750/14143 (20130101)
C12N 2750/14171 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171599 Hotamisligil et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S) Gokhan S. Hotamisligil (Wellesley, Massachusetts);  Ediz Calay (Boston, Massachusetts);  Amir Tirosh (Ramat Gan, Israel);  Gurol Tuncman (Chestnut Hill, Massachusetts);  Motohiro Sekiya (Ibaraki, Japan)
ABSTRACT The present invention provides a method to identify and use compounds for the inhibition of abnormal or dysregulated hepatic glucose production that results in elevated blood glucose levels and associated metabolic disorders. The invention is based on the surprising discovery that the glucagon forms an obligate binding complex with aP2, which is necessary for activation of the glucagon G-coupled protein receptor.
FILED Thursday, July 23, 2020
APPL NO 16/937316
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)

Peptides
C07K 14/605 (20130101) Original (OR) Class
C07K 16/18 (20130101)
C07K 16/26 (20130101)
C07K 2317/24 (20130101)
C07K 2317/32 (20130101)
C07K 2317/34 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/74 (20130101)
G01N 33/92 (20130101)
G01N 2333/605 (20130101)
G01N 2500/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171610 Kanekiyo et al.
FUNDED BY
Department of Defense (DOD)
Uniformed Services University of the Health Sciences (USU)
Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
Department of Health and Human Services (HHS)
APPLICANT(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S) Masaru Kanekiyo (North Bethesda, Maryland);  Michael Gordon Joyce (Washington, District of Columbia);  Wei Bu (Potomac, Maryland);  Jeffrey I. Cohen (Silver Spring, Maryland);  Yaroslav Tsybovsky (Brunswick, Maryland)
ABSTRACT Anti-EBV gH antibodies, anti-EBV gL antibodies, anti-EBV gH/gL antibodies, and compositions of matter useful for the detection, diagnosis, prevention, and treatment of Epstein Barr Virus infection in humans, and methods of using those compositions of matter for the same.
FILED Thursday, May 02, 2019
APPL NO 17/052470
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6803 (20170801)
A61K 47/6839 (20170801)

Peptides
C07K 16/085 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/31 (20130101)
C07K 2317/55 (20130101)
C07K 2317/73 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/705 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56994 (20130101)
G01N 2333/05 (20130101)
G01N 2800/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171612 BAUM et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) REGENERON PHARMACEUTICALS, INC. (Tarrytown, New York)
ASSIGNEE(S)
INVENTOR(S) Alina BAUM (Pleasantville, New York);  Christos KYRATSOUS (Irvington, New York)
ABSTRACT Provided herein are monoclonal antibodies, or antigen-binding fragments thereof, that bind to the influenza B hemagglutinin (HA) protein, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies are useful for inhibiting or neutralizing influenza B virus activity, thus providing a means of treating or preventing influenza infection in humans. Also provided is the use of one or more antibodies that bind to the influenza B HA for preventing viral attachment and/or entry into host cells. The antibodies may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.
FILED Wednesday, October 28, 2020
APPL NO 17/082375
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/16 (20180101)

Peptides
C07K 16/1018 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171645 Ip et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Hong Kong University of Science and Technology (Hong Kong, China PRC);  THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) Nancy Yuk-Yu Ip (Hong Kong, China PRC);  Kit Yu Fu (Hong Kong, China PRC);  Wing Yu Fu (Hong Kong, China PRC);  Dimiter S. Dimitrov (Frederick, Maryland);  Tianlei Ying (Frederick, Maryland)
ABSTRACT The present invention provides new, fully human EphA4 monoclonal antibodies with distinct binding characteristics. Also disclosed are antigen binding fragments of these antibodies, bispecific forms of these antibodies, and conjugates of these antibodies. In addition, nucleic acids encoding these antibodies, antigen binding fragments, bispecific antibodies and conjugates are disclosed. These monoclonal antibodies, antigen binding fragments, bispecific antibodies, conjugates, nucleic acids and vectors are of use for identifying and treating a subject with a disease or condition involving abnormal EphA4-mediated signaling.
FILED Monday, February 15, 2021
APPL NO 17/175879
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/39558 (20130101)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)
A61P 35/00 (20180101)

Peptides
C07K 14/71 (20130101)
C07K 16/2866 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6896 (20130101)
G01N 33/57492 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171651 Green et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Fred Hutchinson Cancer Research Center (Seattle, Washington);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Fred Hutchinson Cancer Research Center (Seattle, Washington);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Damian J. Green (Seattle, Washington);  Yukang Lin (Issaquah, Washington);  Oliver W. Press (Deceased) (Seattle, Washington);  Alice Tzeng (Beachwood, Ohio);  Karl Dane Wittrup (Boston, Massachusetts)
ABSTRACT The present disclosure provides compositions and methods for improved pre-targeted radioimmunotherapeutics (PRIT) to treat various hematological disorders, such as B cell hyperproliferative disorders and solid tumors. The disclosed compositions include bispecific antibody compositions having a first domain that specifically bind to an antigen such as CD38, BCMA, Muc1, GPRC5D, or Slam7 and a second domain that specifically binds to a radioactive ligand. Methods include administering the disclosed bispecific antibody reagent and separately administering the radioactive ligand. In some embodiments, a clearing agent is also administered. In some embodiments, the therapeutic methods comprise administering a combination of two or more bispecific antibody reagents. In some embodiments, an enhancing agent, such as ATRA, gamma secretase inhibitor, or dextramethasone, is also administered to enhance expression of the target antigen on the target cells.
FILED Thursday, November 08, 2018
APPL NO 16/762410
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/203 (20130101)
A61K 39/3955 (20130101)
A61K 45/06 (20130101)
A61K 51/0482 (20130101)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/44 (20130101)
C07K 16/2878 (20130101)
C07K 16/2896 (20130101) Original (OR) Class
C07K 2317/31 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171652 Villa et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Carlos H. Villa (Philadelphia, Pennsylvania);  Vladimir R. Muzykantov (Bryn Athyn, Pennsylvania);  Donald L. Siegel (Lansdale, Pennsylvania);  Colin Greineder (Philadelphia, Pennsylvania)
ABSTRACT Compositions and methods are provided for loading cargoes onto red blood cells. Provided herein are novel antibodies, fragments, fusion proteins and other conjugates which specifically bind red blood cells via RHCE or Band 3.
FILED Wednesday, December 05, 2018
APPL NO 16/768822
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/7455 (20130101)
C07K 16/2896 (20130101) Original (OR) Class
C07K 2317/34 (20130101)
C07K 2317/55 (20130101)
C07K 2317/92 (20130101)
C07K 2317/622 (20130101)
C07K 2319/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171655 KIPPS et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Thomas J. KIPPS (San Diego, California);  Jianqianq Yu (San Diego, California)
ABSTRACT Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The anti-ROR1 scFv antibody and conjugates may include a biologically-active molecule. Such conjugates may comprise a chimeric receptor to direct T cells to respond to ROR1 cancer cells, Methods to use the scFV conjugates to target cells expressing ROR1 for therapeutic and diagnostic purposes are also provided.
FILED Monday, November 09, 2020
APPL NO 17/093474
CURRENT CPC
Peptides
C07K 14/7051 (20130101)
C07K 14/70521 (20130101)
C07K 16/30 (20130101) Original (OR) Class
C07K 16/40 (20130101)
C07K 16/46 (20130101)
C07K 16/468 (20130101)
C07K 2317/24 (20130101)
C07K 2317/31 (20130101)
C07K 2317/622 (20130101)
C07K 2319/00 (20130101)
C07K 2319/33 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57492 (20130101)
G01N 2333/705 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171902 Khoshakhlagh et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute on Aging (NIA)
National Institute of Mental Health (NIMH)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Parastoo Khoshakhlagh (Cambridge, Massachusetts);  Hon Man Alex Ng (Cambridge, Massachusetts);  George M. Church (Cambridge, Massachusetts)
ABSTRACT Provided herein are pluripotent stem cells comprising particular combinations of transcription factor for the production of oligodendrocyte progenitor cells (OPCs). Also provided herein are methods of producing the pluripotent stem cells and methods of using the pluripotent stem cells to produce (OPCs) and oligodendrocytes.
FILED Friday, November 30, 2018
APPL NO 16/768348
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0606 (20130101) Original (OR) Class
C12N 15/86 (20130101)
C12N 15/90 (20130101)
C12N 2501/602 (20130101)
C12N 2501/603 (20130101)
C12N 2506/45 (20130101)
C12N 2800/90 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171912 GENOVESE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) Memphis Meats, Inc. (Berkeley, California);  The Curators of the University of Missouri (Columbia, Missouri)
ASSIGNEE(S)
INVENTOR(S) Nicholas J. GENOVESE (Hayward, California);  R. Michael ROBERTS (Columbia, Missouri);  Bhanu Prakash V. L. TELUGU (College Park, Maryland)
ABSTRACT The present disclosure relates to methods for enhancing cultured meat production, such as livestock-autonomous meat production. In certain aspects, the meat is any metazoan tissue or cell-derived comestible product intended for use as a comestible food or nutritional component by humans, companion animals, domesticated or captive animals whose carcasses are intended for comestible use, service animals, conserved animal species, animals used for experimental purposes, or cell cultures.
FILED Friday, February 12, 2021
APPL NO 17/175324
CURRENT CPC
Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 13/00 (20160801)

Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages
A23V 2002/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/10 (20130101)
C12N 5/0658 (20130101) Original (OR) Class
C12N 2501/40 (20130101)
C12N 2501/60 (20130101)
C12N 2501/72 (20130101)
C12N 2501/392 (20130101)
C12N 2501/415 (20130101)
C12N 2501/602 (20130101)
C12N 2501/603 (20130101)
C12N 2501/604 (20130101)
C12N 2501/727 (20130101)
C12N 2501/999 (20130101)
C12N 2506/02 (20130101)
C12N 2506/45 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171920 Pomerantz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Richard T. Pomerantz (Brooklyn, New York);  Tatiana Kent (Philadelphia, Pennsylvania)
ABSTRACT The invention provides compositions and methods for modifying the 3′-terminal ends of nucleic acids using DNA polymerase θ terminal transferase activity.
FILED Monday, December 14, 2020
APPL NO 17/120973
CURRENT CPC
Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 21/04 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1252 (20130101) Original (OR) Class
C12N 2310/344 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 19/34 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/68 (20130101)
C12Q 1/6806 (20130101)
C12Q 1/6827 (20130101)
C12Q 1/6844 (20130101)
C12Q 1/6853 (20130101)
C12Q 2521/101 (20130101)
C12Q 2525/101 (20130101)
C12Q 2563/137 (20130101)

Enzymes
C12Y 207/07007 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171938 Regev et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Aviv Regev (Cambridge, Massachusetts);  Orit Rozenblatt-Rosen (Cambridge, Massachusetts);  Jellert Gaublomme (Cambridge, Massachusetts);  Bo Li (Cambridge, Massachusetts);  Kathryn Geiger-Schuller (Cambridge, Massachusetts)
ABSTRACT The present invention provides methods and tools for analyzing genetic interactions. The subject matter disclosed herein is generally directed to single cell genomics and proteomics. In one embodiment provided is a method of cell and nuclei hashing using sample barcodes. In another embodiment are method of performing genomewide CRISPR perturbation screens.
FILED Friday, December 07, 2018
APPL NO 16/770380
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1065 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171944 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Klogenix LLC (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Ci-Di Chen (Boston, Massachusetts);  Ella Zeldich (Boston, Massachusetts);  Carmela Abraham (Boston, Massachusetts)
ABSTRACT The present disclosure relates to compositions and methods for modulating gene expression and in particular to compositions and methods for increasing expression of Klotho. For example, the present disclosure provides methods for increasing expression of a Klotho gene in a human cell comprising introducing into the cell a CRISPR enzyme and a guide RNA comprising a guide sequence that is substantially complementary to a target sequence within or near the Klotho gene, wherein the guide RNA or the CRISPR enzyme associates with a transcriptional activation domain.
FILED Tuesday, December 04, 2018
APPL NO 16/762711
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/67 (20130101)
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171949 Kahn et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Joslin Diabetes Center (Boston, Massachusetts)
ASSIGNEE(S) Joslin Diabetes Center (Boston, Massachusetts)
INVENTOR(S) C. Ronald Kahn (Falls Church, Virginia);  Ruben Garcia Martin (Boston, Massachusetts)
ABSTRACT Disclosed herein are exosomal sorting motifs and cellular retention motifs for microRNAs. Methods of use for directing miRNA to exosomes or retaining miRNA in cells are also disclosed.
FILED Friday, January 22, 2021
APPL NO 17/156145
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/34 (20130101)
A61K 35/35 (20130101)
A61K 35/44 (20130101)
A61K 35/407 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/141 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171970 Thelen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) Jay Thelen (Columbia, Missouri);  Matthew Salie (Columbia, Missouri)
ASSIGNEE(S) The Curators of The University of Missouri (Columbia, Missouri)
INVENTOR(S) Jay Thelen (Columbia, Missouri);  Matthew Salie (Columbia, Missouri)
ABSTRACT The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the activity levels of the committed step for de novo fatty acid biosynthesis, acetyl-CoA carboxylases (ACCase). More specifically, methods of the invention directly enhance the activity of ACCase by down-regulating the biotin/lipoyl attachment domain containing (BADC) genes through biotechnology or selective breeding approaches.
FILED Wednesday, November 04, 2020
APPL NO 17/089241
CURRENT CPC
Peptides
C07K 14/415 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/93 (20130101)
C12N 15/87 (20130101)
C12N 15/113 (20130101)
C12N 15/8247 (20130101) Original (OR) Class
C12N 2310/14 (20130101)

Enzymes
C12Y 604/01 (20130101)
C12Y 604/01002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171977 Lu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Timothy Kuan-Ta Lu (Cambridge, Massachusetts);  Lior Nissim (Cambridge, Massachusetts);  Ming-Ru Wu (Brookline, Massachusetts)
ABSTRACT Aspects of the present disclosure provide synthetic promoters that are differentially modulated between certain diseased cells (e.g., cancer cells) and normal cells (e.g., non-cancer cells). These synthetic promoters are useful, for example, for targeted expression of therapeutic molecules in diseased cells.
FILED Tuesday, March 13, 2018
APPL NO 16/493340
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/763 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101) Original (OR) Class
C12N 15/86 (20130101)
C12N 2710/16632 (20130101)
C12N 2710/16643 (20130101)
C12N 2830/008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171979 Peeples et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Research Institute at Nationwide Children's Hospital (Columbus, Ohio);  Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Mark Peeples (Bexley, Ohio);  Jianrong Li (Dublin, Ohio);  Prosper N. Boyaka (Columbus, Ohio);  Anzhong Li (Columbus, Ohio);  Mijia Lu (Columbus, Ohio);  Yuanmei Ma (Pittsburgh, Pennsylvania)
ABSTRACT Embodiments disclosed herein provide compositions, methods, and uses for recombinant vectors encoding Zika virus (ZIKV) protein subunits, and immunogenic compositions thereof. Certain embodiments provide recombinant vectors encoding ZIKV nonstructural protein 1 (NS 1), and optionally, ZIKV envelope (E) protein and premembrane (prM) protein. Other embodiments provide expression cassettes comprising a promoter operably linked to a polynucleotide that encodes the ZIKV NS 1 protein, and optionally ZIKV E and prM proteins. In some embodiments, the disclosed expression cassettes can be incorporated into a vector to produce a recombinant vector. Also provided are immunogenic compositions comprising one or more recombinant vectors described herein, and methods for inducing an immune response against ZIKV in a subject comprising administering to the subject an immunologically effective dose of an immunogenic composition of the present disclosure.
FILED Friday, November 09, 2018
APPL NO 16/762836
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 2039/575 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101) Original (OR) Class
C12N 2760/20243 (20130101)
C12N 2760/20262 (20130101)
C12N 2770/24122 (20130101)
C12N 2770/24134 (20130101)
C12N 2770/24171 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172007 CHEE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Prognosys Biosciences, Inc. (San Diego, California)
ASSIGNEE(S) Prognosys Biosciences, Inc. (San Diego, California)
INVENTOR(S) Mark S. CHEE (San Diego, California);  David A. ROUTENBERG (San Diego, California)
ABSTRACT The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.
FILED Friday, February 19, 2021
APPL NO 17/180356
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/5027 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6809 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172013 Gundlach et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) University of Washington through its Center for Commercialization (Seattle, Washington)
ASSIGNEE(S) University of Washington through its Center for Commercialization (Seattle, Washington)
INVENTOR(S) Jens H. Gundlach (Seattle, Washington);  Andrew Laszlo (Seattle, Washington)
ABSTRACT The present disclosure provides methods and reagents for improving nanopore-based analyses of polymers. Specifically, the disclosure provides a method of analyzing a polymer that includes a polymer analyte that contains an end domain that has at least one charged moiety. The disclosure also provides a method of increasing the interaction rate between a polymer analyte and a nanopore, wherein the polymer analyte contains an end domain that has at least one charged moiety. The disclosure also provide compositions for use with the described methods, including adapter compositions that contain charged moieties, such as phosphate or sulfate groups, and that are configured to being linked to an polymer analyte domain.
FILED Thursday, December 03, 2020
APPL NO 17/111167
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172017 Jin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Mental Health (NIMH)
National Science Foundation (NSF)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Xin Jin (Cambridge, Massachusetts);  Paola Arlotta (Cambridge, Massachusetts);  Aviv Regev (Cambridge, Massachusetts);  Feng Zhang (Cambridge, Massachusetts);  Sean Simmons (Cambridge, Massachusetts)
ABSTRACT Described herein are methods and uses thereof for in vivo evaluating functions of multiple genes in parallel by combining in utero genetic perturbation of progenitor cells and single-cell transcriptomic profiling of progeny cells in animals. These methods can be used, among other things, to reveal in vivo gene functions in a cell type-specific manner.
FILED Friday, January 29, 2021
APPL NO 17/163015
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/907 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 1/6897 (20130101)
C12Q 2600/136 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172021 STEPP et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
APPLICANT(S) THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina)
ASSIGNEE(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S) Wesley Hunter STEPP (Carrboro, North Carolina);  Travis Parke SCHRANK (Chapel Hill, North Carolina)
ABSTRACT Described herein are assays and methods to detect and/or treat a non-responsive or treatment resistant p16 positive tumor in a subject in need thereof. The disclosed method can also involve determining if the subject is HPV positive or negative, whether the HPV is integrated or episomal, and selecting a suitable treatment based on these determinations. Also disclosed herein is a method of treating an oropharyngeal squamous cell carcinoma in a subject using the arrays and methods disclosed herein.
FILED Friday, April 12, 2019
APPL NO 17/046514
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/708 (20130101)
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/106 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172022 Kurtz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) David M. Kurtz (San Francisco, California);  Maximilian Diehn (San Carlos, California);  Arash Ash Alizadeh (San Mateo, California)
ABSTRACT Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.
FILED Monday, November 30, 2020
APPL NO 17/107668
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6874 (20130101)
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2565/60 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/20 (20190201)
G16B 35/20 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172025 Vogelstein et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Bert Vogelstein (Baltimore, Maryland);  Kenneth W. Kinzler (Baltimore, Maryland);  Victor Velculescu (Dayton, Maryland);  Luis Diaz (Ellicot City, Maryland);  Rebecca J. Leary (Baltimore, Maryland)
ABSTRACT Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE), which can identify translocations in solid tumors. Analysis of four colorectal and two breast cancers revealed an average of nine rearranged sequences (range 4 to 15) per tumor. Polymerase chain reaction with primers spanning the breakpoints were able to detect mutant DNA molecules present at levels lower than 0.001% and readily identified mutated circulating DNA in patient plasma samples. This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients.
FILED Wednesday, December 16, 2020
APPL NO 17/123319
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/156 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172026 Cornell et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S) Liam Cornell (Brookline, Massachusetts);  Geoffrey I. Shapiro (Boston, Massachusetts)
ABSTRACT The present invention relates to compositions and methods for detecting CDK4/6 response and resistance.
FILED Monday, January 25, 2021
APPL NO 17/157653
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/506 (20130101)
A61K 31/519 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1137 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6809 (20130101)
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/106 (20130101)
C12Q 2600/112 (20130101)
C12Q 2600/118 (20130101)
C12Q 2600/166 (20130101)
C12Q 2600/178 (20130101)

Enzymes
C12Y 207/11022 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 25/10 (20190201)
G16B 30/00 (20190201)
G16B 40/00 (20190201)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/10 (20180101)
G16H 50/20 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172856 ZHAO
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Qi ZHAO (West Hartford, Connecticut);  Enrich Therapeutics Inc. (Branford, Connecticut)
ASSIGNEE(S) Enrich Therapeutics Inc. (Branford, Connecticut)
INVENTOR(S) Qi ZHAO (West Hartford, Connecticut)
ABSTRACT The present disclosure provides, among other things, methods and devices for single cells/particle selection and isolation from a sample in a light-curable biomatrix gel. The individual cells or particles are observed by microscopy and manipulated and isolated by accurately controlling the light transmission from a liquid crystal display (LCD) oriented under the sample to provide a detailed image of the sample. In some embodiments, selected cells or particles are then immobilized by curing the biomatrix gel with blue/violet light transmitted from a LED pixel array. In other embodiments, the selected cells or particles of interest are allowed to remain mobile. In either embodiment, the individual cells or particles of interest are segregated from and isolated from the remainder of the sample.
FILED Friday, August 16, 2019
APPL NO 17/267888
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1434 (20130101)
G01N 15/1463 (20130101)
G01N 15/1475 (20130101) Original (OR) Class
G01N 2015/149 (20130101)
G01N 2015/1447 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172934 McAllister et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Sandra S. McAllister (Boston, Massachusetts);  Jessica F. Olive (Worcester, Massachusetts)
ABSTRACT Clonally derived barcoded cell populations and methods of generating the same, as well as methods of use thereof, e.g., to evaluate heterogeneity of a starting population of cells.
FILED Friday, December 11, 2020
APPL NO 17/119245
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5011 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172957 Chiu
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Daniel T. Chiu (Seattle, Washington)
ABSTRACT Methods, systems, compositions and kits are provided for the analysis of target molecules using chromophoric polymer dots conjugated to biomolecules. The use of chromophoric polymer dots improves detection sensitivity and stability when compared with existing techniques. In some aspects, methods, systems, and kits are provided for detecting a target protein using chromophoric polymer dots conjugated to biomolecules in a Western blot analysis. Related methods, systems, compositions and kits are also provided.
FILED Friday, February 12, 2021
APPL NO 17/175408
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/588 (20130101) Original (OR) Class
G01N 33/6803 (20130101)
G01N 2458/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172959 YANG et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California);  U.S. Government Represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S) Andrew YANG (Stanford, California);  Anton WYSS-CORAY (Stanford, California);  Kyle BREWER (Stanford, California)
ABSTRACT Provided herein are methods for labeling the proteomes of cells, as well as methods for labeling proteins or populations of proteins produced by cells. In some embodiments, the methods comprise introducing variant aminoacyl-tRNA synthetases and noncanonical amino acids into cells. Also provided herein are polynucleotides encoding variant aminoacyl-tRNA synthetases that recognize noncanonical amino acids. The methods and compositions provided herein are useful for, among other things, identifying target cells and identifying biomarkers of interest.
FILED Thursday, November 05, 2020
APPL NO 17/090261
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/93 (20130101)

Enzymes
C12Y 601/0102 (20130101)
C12Y 601/01001 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6842 (20130101) Original (OR) Class
G01N 2333/9015 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172961 ZHANG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas);  Immatics Biotechnologies GmbH (Tuebingen, Germany)
ASSIGNEE(S)
INVENTOR(S) Minying ZHANG (Houston, Texas);  Jens FRITSCHE (Dusslingen, Germany);  Patrick HWU (Houston, Texas)
ABSTRACT The present disclosure relates to methods of identifying RNA-edited peptides. In an aspect, the identified peptides are capable of eliciting immune responses in individuals or patients. The present disclosure further relates to RNA-edited peptide sequences identified by methods described herein. In a further aspect, the disclosure provides for methods of treating cancer in individuals or patients by utilizing the methodology described herein.
FILED Friday, July 26, 2019
APPL NO 17/263094
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/505 (20130101)
G01N 33/6818 (20130101)
G01N 33/6848 (20130101)
G01N 33/6878 (20130101) Original (OR) Class
G01N 2333/70539 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173188 JOHNSON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) ALLEN INSTITUTE (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Gregory JOHNSON (Seattle, Washington);  Chawin OUNKOMOL (Seattle, Washington);  Forrest COLLMAN (Seattle, Washington);  Sharmishtaa SESHAMANI (Shoreline, Washington)
ABSTRACT A computing device, method, system, and instructions in a non-transitory computer-readable medium for performing image analysis on 3D microscopy images to predict localization and/or labeling of various structures or objects of interest, by predicting the location in such images at which a dye or other marker associated with such structures would appear. The computing device, method, and system receives sets of 3D images that include unlabeled images, such as transmitted light images or electron microscope images, and labeled images, such as images captured with fluorescence tagging. The computing device trains a statistical model to associate structures in the labeled images with the same structures in the unlabeled light images. The processor further applies the statistical model to a new unlabeled image to generate a predictive labeled image that predicts the location of a structure of interest in the new image.
FILED Wednesday, January 13, 2021
APPL NO 17/148192
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/008 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)
G06N 3/0454 (20130101)
G06N 20/20 (20190101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/174 (20170101)
G06T 7/187 (20170101)
G06T 2207/10061 (20130101)
G06T 2207/10064 (20130101)
G06T 2207/30024 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173195 Hillman
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Elizabeth M.C. Hillman (New York, New York)
ABSTRACT Methods, devices and systems for up to three-dimensional scanning of target regions at high magnification are disclosed.
FILED Wednesday, September 30, 2020
APPL NO 17/038902
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/0032 (20130101)
G02B 21/0052 (20130101)
G02B 21/361 (20130101)
G02B 21/367 (20130101) Original (OR) Class
G02B 23/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210174504 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  Louis Stokes Cleveland Veterans Administration Medical Center (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Nathaniel Braman (Bethel Park, Pennsylvania);  Tristan Maidment (Cleveland, Ohio);  Yijiang Chen (Cleveland, Ohio)
ABSTRACT Embodiments discussed herein facilitate determination of whether lesions are benign or malignant. One example embodiment is a method, comprising: accessing medical imaging scan(s) that are each associated with distinct angle(s) and each comprise a segmented region of interest (ROI) of that medical imaging scan comprising a lesion associated with a first region and a second region; providing the first region(s) of the medical imaging scan(s) to trained first deep learning (DL) model(s) of an ensemble and the second region(s) of the medical imaging scan(s) to trained second DL model(s) of the ensemble; and receiving, from the ensemble of DL models, an indication of whether the lesion is a benign architectural distortion (AD) or a malignant AD.
FILED Wednesday, December 09, 2020
APPL NO 17/116366
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 6/025 (20130101)
A61B 6/469 (20130101)
A61B 6/502 (20130101)
A61B 6/5217 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6256 (20130101)
G06K 2209/05 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/04 (20130101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/0012 (20130101) Original (OR) Class
G06T 2207/10112 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30068 (20130101)
G06T 2207/30096 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 30/40 (20180101)
G16H 50/20 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210174966 Jacobs et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Oregon Health and Science University (Portland, Oregon)
ASSIGNEE(S)
INVENTOR(S) Peter G. Jacobs (Portland, Oregon);  Clara Mosquera-Lopez (Portland, Oregon);  Nichole Tyler (Portland, Oregon);  Robert Dodier (Portland, Oregon);  Jessica Castle (Portland, Oregon);  Joseph E. Youssef (Portland, Oregon);  Leah Wilson (Portland, Oregon)
ABSTRACT Disclosed are techniques for supporting glucoregulatory management decisions using a decision support recommender to predict an occurrence of a hypoglycemic event in an incognizant living subject. Glucose management data is obtained from a living subject. It is processed as prescribed by a feature extractor to generate a set of glucoregulatory feature values. The glucoregulatory feature values are applied as prescribed by the feature extractor to a hypoglycemia prediction model. The hypoglycemia prediction model is formulated to predict the occurrence of a hypoglycemic event during a period of incognizance of the living subject. A glucoregulatory management recommendation is generated as prescribed by the decision support recommender if the hypoglycemia prediction model predicts the occurrence of a hypoglycemic event during the period of incognizance.
FILED Monday, December 07, 2020
APPL NO 17/114433
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/60 (20180101)
G16H 20/17 (20180101)
G16H 20/30 (20180101)
G16H 20/60 (20180101)
G16H 50/30 (20180101) Original (OR) Class
G16H 50/50 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20210169349 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  Louis Stokes Cleveland Veterans Administration Medical Center (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Nathaniel Braman (Bethel Park, Pennsylvania)
ABSTRACT Embodiments discussed herein facilitate determination of a response to treatment and/or a prognosis for a tumor based at least in part on features of tumor-associated vasculature (TAV). One example embodiment is a method, comprising: accessing a medical imaging scan of a tumor, wherein the tumor is segmented on the medical imaging scan; segmenting tumor-associated vasculature (TAV) associated with the tumor based on the medical imaging scan; extracting one or more features from the TAV; providing the one or more features extracted from the TAV to a trained machine learning model; and receiving, from the machine learning model, one of a predicted response to a treatment for the tumor or a prognosis for the tumor.
FILED Wednesday, December 09, 2020
APPL NO 17/116319
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/004 (20130101)
A61B 5/08 (20130101)
A61B 5/0035 (20130101)
A61B 5/02007 (20130101) Original (OR) Class
A61B 5/7267 (20130101)
A61B 5/7275 (20130101)
A61B 6/481 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 7/12 (20170101)
G06T 2207/10081 (20130101)
G06T 2207/10088 (20130101)
G06T 2207/20036 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/30061 (20130101)
G06T 2207/30068 (20130101)
G06T 2207/30096 (20130101)
G06T 2207/30101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169984 Lee et al.
FUNDED BY
Department of Defense (DOD)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Seulki Lee (Elkridge, Maryland);  Martin Pomper (Baltimore, Maryland);  Yumin Oh (Elkridge, Maryland);  Magdalena Scully (Mount Airy, Maryland)
ABSTRACT The present invention relates to methods for sensitizing cancers to death receptor agonist therapies, comprising use of one or more kinase inhibitors. Such kinase inhibitors can be administered and identified as effective for sensitizing to death receptor agonist therapy in vitro or in vivo. Screening for additional kinase inhibitors and other agents that sensitize cancer cells to death receptor agonists is also contemplated, as is preventing and/or treatment of cancer using combination therapies that include such agents (e.g., kinase inhibitor(s) and death receptor agonist(s)). Formulations and kits including such combined agents are also contemplated and described, as are diagnostic/imaging agents that allow for advanced tracking of therapeutic outcome.
FILED Thursday, January 19, 2017
APPL NO 16/071116
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/20 (20130101)
A61K 9/0053 (20130101)
A61K 31/44 (20130101)
A61K 31/52 (20130101)
A61K 31/53 (20130101)
A61K 31/194 (20130101)
A61K 31/277 (20130101)
A61K 31/352 (20130101)
A61K 31/404 (20130101)
A61K 31/437 (20130101)
A61K 31/444 (20130101)
A61K 31/453 (20130101)
A61K 31/454 (20130101)
A61K 31/496 (20130101)
A61K 31/506 (20130101)
A61K 31/517 (20130101)
A61K 31/519 (20130101)
A61K 31/4439 (20130101)
A61K 31/4465 (20130101)
A61K 31/4706 (20130101)
A61K 31/4709 (20130101)
A61K 31/4745 (20130101)
A61K 31/4985 (20130101)
A61K 31/5025 (20130101)
A61K 31/5377 (20130101)
A61K 38/191 (20130101) Original (OR) Class
A61K 47/60 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5011 (20130101)
G01N 2333/912 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170005 Sayour et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Elias Sayour (Gainesville, Florida);  Duane Mitchell (Gainesville, Florida)
ABSTRACT The present disclosure provides methods of increasing sensitivity of a tumor to treatment with an immune checkpoint inhibitor (ICI) in a subject and methods of treating a subject with an immune checkpoint inhibitor (ICI)-resistant tumor. The methods comprise administering to the subject a composition comprising a liposome comprising a cationic lipid and mRNA molecules, wherein the liposome is systemically administered to the subject. Also provided are methods of increasing the number of activated plasmacytoid dendritic cells (pDCs) in a subject in need thereof, comprising administering to the subject a composition comprising a liposome comprising a cationic lipid and mRNA molecules, wherein the liposome is systemically administered to the subject. Combination therapy with anti-PD-L1 mAb. Related methods of treatment and methods of preparing a dendritic cell vaccine are additionally provided.
FILED Thursday, August 15, 2019
APPL NO 17/268408
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/127 (20130101)
A61K 35/15 (20130101)
A61K 39/001193 (20180801) Original (OR) Class
A61K 39/3955 (20130101)
A61K 47/186 (20130101)
A61K 47/6911 (20170801)
A61K 2039/53 (20130101)
A61K 2039/54 (20130101)
A61K 2039/5154 (20130101)
A61K 2039/55555 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0639 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170007 Super et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Michael Super (Lexington, Massachusetts);  Edward J. Doherty (Mansfield, Massachusetts);  Mark Joseph Cartwright (West Newton, Massachusetts);  Des White (Oxford, Massachusetts);  Alexander Stafford (Revere, Massachusetts);  Omar Abdel-Rahman Ali (Oakland, California);  Amanda Graveline (Boston, Massachusetts);  Donald E. Ingber (Boston, Massachusetts);  David J. Mooney (Sudbury, Massachusetts);  Benjamin Seiler (Boston, Massachusetts)
ABSTRACT The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.
FILED Wednesday, September 09, 2020
APPL NO 17/015177
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/025 (20130101)
A61K 39/0258 (20130101) Original (OR) Class
A61K 2039/6093 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170014 Flavell et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Richard Flavell (Guilford, Connecticut);  Noah Palm (New Haven, Connecticut);  Marcel De Zoete (New Haven, Connecticut)
ABSTRACT The invention relates to compositions and methods for treating inflammatory diseases and disorders in a subject in need thereof. In certain aspects, the invention relates to immunogenic compositions (e.g., vaccines) to diminish the number or pathogenic effects of one or more bacteria associated with the development or progression of an inflammatory disease or disorder.
FILED Thursday, February 18, 2021
APPL NO 17/178412
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0053 (20130101)
A61K 39/0008 (20130101)
A61K 39/39 (20130101)
A61K 39/116 (20130101) Original (OR) Class
A61K 2039/58 (20130101)
A61K 2039/577 (20130101)
A61K 2039/55544 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 29/00 (20180101)
A61P 31/04 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170360 Lu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
National Aeronautics and Space Administration (NASA)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Jennifer Lu (Merced, California);  Wenxin Fu (Merced, California)
ABSTRACT A platform and system for concentration, reduction and regeneration of heavy metals and other contaminants from fluids is provided. The platform has a three-tiered hierarchical porous structure, composed of micropores formed by woven carbon cloth, nanopores formed after carbon nanotube growth on the cloth fibers and mesopores formed by a polymer outer layer. The material of the platform can be incorporated into cells with two electrodes with properly functionalized PDAN grafted 3D carbon as an anode and cathode respectively. Metal ions and toxic anions in water will be captured selectively by primary amine, secondary amine and quaternary amine groups in porous PDAN on the anode. Metals are captured and reduced by the cathode.
FILED Thursday, December 31, 2020
APPL NO 17/139813
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/205 (20130101) Original (OR) Class
B01J 20/262 (20130101)
B01J 20/265 (20130101)
B01J 20/3204 (20130101)
B01J 20/3219 (20130101)
B01J 20/3272 (20130101)
B01J 20/3295 (20130101)
B01J 20/28011 (20130101)
B01J 20/28033 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/4678 (20130101)
C02F 1/46109 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170377 Flaherty et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Army Research Office (ARO)
APPLICANT(S) The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S) The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S) David William Flaherty (Urbana, Illinois);  Daniel T. Bregante (Urbana, Illinois)
ABSTRACT The invention provides methods for completely removing aluminum from existing zeolite frameworks that have been previously considered unalterable due to their small pore sizes and stable crystal structures. Consequently, new combinations of metal atoms and zeolite structures can now be made using the methods disclosed herein. Metal atoms that have useful properties for catalysis and adsorption have been integrated into zeolite structures that provide advantageous size selection or solvation properties to increase rates, conversions, and yields of catalytic processes. The disclosed catalysts and methods reduce the cost of synthesizing useful materials and zeolite structures with compositions of matter that have not been reported.
FILED Friday, December 04, 2020
APPL NO 17/112537
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 29/89 (20130101) Original (OR) Class
B01J 35/1057 (20130101)
B01J 35/1061 (20130101)
B01J 37/06 (20130101)
B01J 37/009 (20130101)
B01J 37/30 (20130101)
B01J 2229/16 (20130101)
B01J 2229/37 (20130101)
B01J 2229/183 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 39/20 (20130101)
C01B 39/065 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2006/16 (20130101)

Heterocyclic Compounds
C07D 301/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171135 Blankespoor et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Boston Dynamics, Inc. (Waltham, Massachusetts)
ASSIGNEE(S) Boston Dynamics, Inc. (Waltham, Massachusetts)
INVENTOR(S) Kevin Blankespoor (Arlington, Massachusetts);  Alex Perkins (Arlington, Massachusetts);  Marco da Silva (Arlington, Massachusetts)
ABSTRACT An example method may include i) determining a first distance between a pair of feet of a robot at a first time, where the pair of feet is in contact with a ground surface; ii) determining a second distance between the pair of feet of the robot at a second time, where the pair of feet remains in contact with the ground surface from the first time to the second time; iii) comparing a difference between the determined first and second distances to a threshold difference; iv) determining that the difference between determined first and second distances exceeds the threshold difference; and v) based on the determination that the difference between the determined first and second distances exceeds the threshold difference, causing the robot to react.
FILED Tuesday, January 26, 2021
APPL NO 17/158471
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/1694 (20130101)

Motor Vehicles; Trailers
B62D 57/02 (20130101) Original (OR) Class

Systems for Controlling or Regulating Non-electric Variables
G05D 1/027 (20130101)

Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests
Y10S 901/01 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171223 McDevitt et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
National Aeronautics and Space Administration (NASA)
APPLICANT(S) University of Vermont and State Agricultural College (Burlington, Vermont)
ASSIGNEE(S)
INVENTOR(S) Michael Ryan McDevitt (Burlington, Vermont);  Darren L. Hitt (Jericho, Vermont);  Patrick Lee (South Burlington, Vermont);  Sandra Romero Diez (Burlington, Vermont);  Alex Golden (Waban, Massachusetts);  Kevin Mongeon (Milton, Vermont);  Jon Watts (Wallingford, Vermont);  Lydia Hantsche (Burlington, Vermont);  Matthew Shea (Elverson, Pennsylvania)
ABSTRACT Propulsion systems that generate thrust from pressure generated by thermally decomposing a chemical blowing agent (CBA). In some embodiments, the CBA decomposes exothermically such that once thermal decomposition has been initiated, the thermal decomposition continues without additional energy input. In some embodiments, the CBA is utilized in a digital-microthruster array containing microthrusters that can be individually activated to provide thrust. In some embodiments, a CBA may be stored in one or more CBA-storage chambers that can be individually activated to charge and/or recharge a pressure tank that stores gas from the CBA decomposition under pressure for providing thrust. These and other embodiments are disclosed. Such propulsion systems can be used for any of a variety of spacecraft, including micro- and nano-satellites. Corresponding methods of generating thrust are also disclosed.
FILED Tuesday, June 12, 2018
APPL NO 16/622580
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/10 (20130101)
B64G 1/402 (20130101)
B64G 1/409 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171351 Tour et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) WILLIAM MARSH RICE UNIVERSITY (Houston, Texas)
ASSIGNEE(S) WILLIAM MARSH RICE UNIVERSITY (Houston, Texas)
INVENTOR(S) James M. Tour (Bellaire, Texas);  Duy X. Luong (Houston, Texas);  Ajay Subramanian (Fort Collins, Colorado)
ABSTRACT Laser-induced graphene (LIG) and laser-induced graphene scrolls (LIGS) materials and, more particularly to LIGS, methods of making LIGS (such as from polyimide (PI)), laser-induced removal of LIG and LIGS, and 3D printing of LIG and LIGS using a laminated object manufacturing (LOM) process.
FILED Monday, November 23, 2020
APPL NO 17/102271
CURRENT CPC
Separation
B01D 71/021 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 32/18 (20170801)
C01B 32/184 (20170801) Original (OR) Class

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 73/10 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/625 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171417 Epshteyn et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Albert Epshteyn (Potomac, Maryland);  Andrew P. Purdy (Alexandria, Virginia)
ABSTRACT A nanoparticle of a decomposition product of a transition metal aluminum hydride compound, a transition metal borohydride compound, or a transition metal gallium hydride compound. A process of: reacting a transition metal salt with an aluminum hydride compound, a borohydride compound, or a gallium hydride compound to produce one or more of the nanoparticles. The reaction occurs in solution while being sonicated at a temperature at which the metal hydride compound decomposes. A process of: reacting a nanoparticle with a compound containing at least two hydroxyl groups to form a coating having multi-dentate metal-alkoxides.
FILED Thursday, December 03, 2020
APPL NO 17/110580
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 1/0018 (20130101)
B22F 1/0062 (20130101)
B22F 9/24 (20130101)
B22F 2998/10 (20130101)
B22F 2999/00 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)

Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives
C06B 45/32 (20130101)
C06B 45/34 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171418 Epshteyn et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Albert Epshteyn (Potomac, Maryland);  Andrew P. Purdy (Alexandria, Virginia)
ABSTRACT A nanoparticle of a decomposition product of a transition metal aluminum hydride compound, a transition metal borohydride compound, or a transition metal gallium hydride compound. A process of: reacting a transition metal salt with an aluminum hydride compound, a borohydride compound, or a gallium hydride compound to produce one or more of the nanoparticles. The reaction occurs in solution while being sonicated at a temperature at which the metal hydride compound decomposes. A process of: reacting a nanoparticle with a compound containing at least two hydroxyl groups to form a coating having multi-dentate metal-alkoxides.
FILED Thursday, December 03, 2020
APPL NO 17/110593
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 1/0018 (20130101)
B22F 1/0062 (20130101)
B22F 9/24 (20130101)
B22F 2998/10 (20130101)
B22F 2999/00 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)

Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives
C06B 45/32 (20130101)
C06B 45/34 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171502 Ji et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)
INVENTOR(S) Haitao Ji (Salt Lake City, Utah);  Min Zhang (Salt Lake City, Utah)
ABSTRACT In one aspect, the invention relates to 4-substituted benzoylpiperazine-1-substituted carbonyls, derivatives thereof, and related compounds; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g., various tumors and cancers, associated with β-catenin/BCL9 protein-protein interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED Friday, March 24, 2017
APPL NO 16/087553
CURRENT CPC
Heterocyclic Compounds
C07D 403/12 (20130101) Original (OR) Class
C07D 403/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171557 Huang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
APPLICANT(S) NUtech Ventures (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Jinsong Huang (Lincoln, Nebraska);  Yang Bai (Westlake, Australia)
ABSTRACT Systems and methods for enhancing the stability and efficiency of perovskite materials, and devices incorporating such perovskite materials. A method of making a perovskite layer includes mixing a perovskite solution with a silica shell precursor solution to produce a perovskite-silica precursor solution, and spin casting or drop casting the perovskite-silica precursor solution on a substrate to form a perovskite material or material layer, wherein the perovskite material or material layer includes a plurality of groups of one or more perovskite grains, each of said plurality of groups wrapped in a silica shell. The silica shell precursor solution may have a chemical structure of Rn—Si—(OR)4-n, where “R” is an alkyl, aryl, or organofunctional group, and “OR” is a methoxy, ethoxy, or acetoxy group.
FILED Tuesday, December 10, 2019
APPL NO 16/709339
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 13/005 (20130101) Original (OR) Class

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/442 (20130101)
H01L 51/448 (20130101)
H01L 51/4213 (20130101)
H01L 51/4266 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171582 Flynn et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Michael J. Flynn (Pasadena, California);  Michael B. Elowitz (Pasadena, California);  Acacia Hori (Pasadena, California);  Viviana Gradinaru (La Canada Flintridge, California)
ABSTRACT Disclosed herein include methods, compositions, and kits suitable for robust and tunable control of payload gene expression. Some embodiments provide rationally designed circuits, including miRNA-level and/or protein-level incoherent feed-forward loop circuits, that maintain the expression of a payload at an efficacious level. The circuit can comprise a promoter operably linked to a polynucleotide encoding a fusion protein comprising a payload protein, a protease, and one or more self-cleaving peptide sequences. The payload protein can comprise a degron and a cut site the protease is capable of cutting to expose the degron. The circuit can comprise a promoter operably linked to a polynucleotide comprising a payload gene, a silencer effector cassette, and one or more silencer effector binding sequences.
FILED Saturday, November 21, 2020
APPL NO 17/100857
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/005 (20130101) Original (OR) Class
C07K 2319/71 (20130101)
C07K 2319/95 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171584 Jewett et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Michael Christopher Jewett (Evanston, Illinois);  Benjamin James Des Soye (Evanston, Illinois);  Samuel Ryan Davidson (Evanston, Illinois)
ABSTRACT Disclosed are compositions, methods, and kits for performing cell-free RNA transcription and/or cell-free protein synthesis (CFPS). The disclosed compositions, methods, and kits include or utilize components prepared from Vibrio species such as cellular extracts from Vibrio natriegens.
FILED Monday, November 12, 2018
APPL NO 16/762889
CURRENT CPC
Peptides
C07K 1/00 (20130101)
C07K 14/28 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171610 Kanekiyo et al.
FUNDED BY
Department of Defense (DOD)
Uniformed Services University of the Health Sciences (USU)
Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
Department of Health and Human Services (HHS)
APPLICANT(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S) Masaru Kanekiyo (North Bethesda, Maryland);  Michael Gordon Joyce (Washington, District of Columbia);  Wei Bu (Potomac, Maryland);  Jeffrey I. Cohen (Silver Spring, Maryland);  Yaroslav Tsybovsky (Brunswick, Maryland)
ABSTRACT Anti-EBV gH antibodies, anti-EBV gL antibodies, anti-EBV gH/gL antibodies, and compositions of matter useful for the detection, diagnosis, prevention, and treatment of Epstein Barr Virus infection in humans, and methods of using those compositions of matter for the same.
FILED Thursday, May 02, 2019
APPL NO 17/052470
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6803 (20170801)
A61K 47/6839 (20170801)

Peptides
C07K 16/085 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/31 (20130101)
C07K 2317/55 (20130101)
C07K 2317/73 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/705 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56994 (20130101)
G01N 2333/05 (20130101)
G01N 2800/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171704 Michl et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Army Research Office (ARO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
INVENTOR(S) Josef Michl (Boulder, Colorado);  Thomas Frank Magnera (Boulder, Colorado)
ABSTRACT Methods of forming a porphene polymeric material are provided. The resulting material can be a porphene or a metalloporphene polymeric material. The structure of the polymer can be selected based on a material provided in the monomer material. Methods of using the polymeric material are also provided.
FILED Friday, December 04, 2020
APPL NO 17/112865
CURRENT CPC
Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 61/122 (20130101) Original (OR) Class
C08G 85/004 (20130101)
C08G 2261/40 (20130101)
C08G 2261/374 (20130101)
C08G 2261/376 (20130101)
C08G 2261/3241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171725 Herring et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
APPLICANT(S) Colorado School of Mines (Golden, Colorado);  University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S) COLORADO SCHOOL OF MINES (Golden, Colorado);  University of Massachusetts (Boston, Massachusetts)
INVENTOR(S) Andrew M. Herring (Boulder, Colorado);  Mei-Chen Kuo (Denver, Colorado);  E. Bryan Coughlin (Amherst, Massachusetts);  Nora Buggy (Golden, Colorado);  Yifeng Du (Amherst, Massachusetts)
ABSTRACT The present invention relates to a high performance cross-linked triblock cationic functionalized polymer for electrochemical applications, and methods of making and using the same. The invention also relates to a tunable hydrogenated polymer, that can be functionalized with a particular cation for a particular application, and the method of making the hydrogenated polymer and tuning the hydrogenated polymer for the application.
FILED Thursday, November 12, 2020
APPL NO 17/096483
CURRENT CPC
Separation
B01D 71/80 (20130101)
B01D 71/82 (20130101)

Treatment or Chemical Modification of Rubbers
C08C 19/22 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 8/04 (20130101)
C08F 8/26 (20130101)
C08F 8/32 (20130101)
C08F 8/34 (20130101)
C08F 8/40 (20130101)
C08F 8/44 (20130101)
C08F 212/12 (20130101)
C08F 212/36 (20130101)
C08F 232/00 (20130101)
C08F 299/00 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/24 (20130101)
C08J 3/28 (20130101)
C08J 3/246 (20130101) Original (OR) Class
C08J 7/12 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/19 (20130101)
C08K 5/3415 (20130101)
C08K 5/3435 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171783 Jiang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Shaoyi Jiang (Seattle, Washington);  Hsiang-Chieh Hung (Seattle, Washington);  Dianyu Dong (Seattle, Washington);  Caroline Tsao (Seattle, Washington);  Chenjue Tang (Seattle, Washington);  Joel MacArthur (Seattle, Washington)
ABSTRACT Zwitterionic double network hydrogels, methods for making zwitterionic double network hydrogels, methods for using zwitterionic double network hydrogels, and articles made from and coated with zwitterionic double network hydrogels.
FILED Wednesday, August 14, 2019
APPL NO 17/268310
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/34 (20130101)
A61L 27/52 (20130101)
A61L 29/085 (20130101)
A61L 29/145 (20130101)
A61L 31/10 (20130101)
A61L 31/145 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/075 (20130101)
C08J 3/246 (20130101)
C08J 2300/208 (20130101)
C08J 2381/10 (20130101)
C08J 2477/00 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 5/1637 (20130101)
C09D 5/1662 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171798 Ramsey et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) John Michael Ramsey (Chapel Hill, North Carolina);  William Hampton Henley (Chapel Hill, North Carolina)
ABSTRACT Described herein are compositions, devices, and methods for improving a surface property of a substrate. In some embodiments, the hydrophobicity and/or fluorocarbon-phobicity of the surface is increased. Some embodiments include compositions, devices and methods for improving bead loading and/or immiscible oil sealing of microwell array reactions on plastic microfluidic devices.
FILED Wednesday, May 15, 2019
APPL NO 17/048114
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502707 (20130101)
B01L 2300/165 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 5/00 (20130101)
C09D 7/20 (20180101)
C09D 183/08 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171893 Brown et al.
FUNDED BY
Department of Defense (DOD)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S) Duke University (Durham, North Carolina)
INVENTOR(S) David Brown (Durham, North Carolina);  Gayathri Devi (Durham, North Carolina)
ABSTRACT The present disclosure comprises a lymphovascular bioreactor system and methods of making and using same.
FILED Friday, November 09, 2018
APPL NO 16/762857
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/14 (20130101)
C12M 25/04 (20130101)
C12M 35/08 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5017 (20130101)
G01N 33/57415 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171977 Lu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Timothy Kuan-Ta Lu (Cambridge, Massachusetts);  Lior Nissim (Cambridge, Massachusetts);  Ming-Ru Wu (Brookline, Massachusetts)
ABSTRACT Aspects of the present disclosure provide synthetic promoters that are differentially modulated between certain diseased cells (e.g., cancer cells) and normal cells (e.g., non-cancer cells). These synthetic promoters are useful, for example, for targeted expression of therapeutic molecules in diseased cells.
FILED Tuesday, March 13, 2018
APPL NO 16/493340
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/763 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101) Original (OR) Class
C12N 15/86 (20130101)
C12N 2710/16632 (20130101)
C12N 2710/16643 (20130101)
C12N 2830/008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172355 Scanlon, SR.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
APPLICANT(S) U.S. Army Combat Capabilities Development Command, Army Research Labortary (Adelphi, Maryland)
ASSIGNEE(S)
INVENTOR(S) Michael V. Scanlon, SR. (Laurel, Maryland)
ABSTRACT Apparatus for attenuating a sound level comprising an enclosure having an inlet and an outlet, where an exhaust flow director is positioned within the enclosure and fluidly coupled to the inlet and the outlet. The exhaust flow director comprises a plurality of overlapping vanes that directs the exhaust flow to attenuate the level of the sound produced by the exhaust.
FILED Friday, June 05, 2020
APPL NO 16/893465
CURRENT CPC
Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines
F01N 1/12 (20130101) Original (OR) Class

Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for
G10K 11/162 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172460 Keplinger et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Army Research Office (ARO)
National Aeronautics and Space Administration (NASA)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S) Christoph Matthias Keplinger (Gerlinger, Germany);  Xingrui Wang (Stuttgart, Germany);  Shane Karl Mitchell (Denver, Colorado)
ABSTRACT High strain hydraulically amplified self-healing electrostatic transducers having increased maximum theoretical and practical strains are disclosed. In particular, the actuators include electrode configurations having a zipping front created by the attraction of the electrodes that is configured orthogonally to a strain axis along which the actuators. This configuration produces increased strains. In turn, various form factors for the actuator configuration are presented including an artificial circular muscle and a strain amplifying pulley system. Other actuator configurations are contemplated that include independent and opposed electrode pairs to create cyclic activation, hybrid electrode configurations, and use of strain limiting layers for controlled deflection of the actuator.
FILED Thursday, December 10, 2020
APPL NO 17/117418
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/1075 (20130101)

Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for
F15B 5/006 (20130101) Original (OR) Class
F15B 15/103 (20130101)
F15B 21/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172713 Brown et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Science Applications International Corporation (Reston, Virginia)
ASSIGNEE(S)
INVENTOR(S) Peter Brown (Summerville, South Carolina);  George S. Chryssomallis (Excelsior, Minnesota);  Eric Smay (Mount Pleasant, South Carolina)
ABSTRACT Aluminum structures, such as tactical vehicle hulls, include plural aluminum components formed from a first alloy composition and joined by one or more welded seam(s). The welded seam(s) may be formed by friction stir welding and/or gas metal arc welding using welding wire made from the first alloy composition. In this manner, all component parts are made from the same alloy composition, providing a more homogeneous structure. The welded component parts then may be placed in a heat treatment furnace to temper the structure. Because essentially all of the aluminum structure before heat treating—the welded seam(s) and the individual component parts—is formed of the same starting material and these parts/seam(s) are simultaneously and evenly heat treated, the resultant hardened, heat-treated part (e.g., a vehicle hull) has a more homogeneous hardened/heat treated structure in the individual parts and across the welded seam(s).
FILED Friday, December 06, 2019
APPL NO 16/706116
CURRENT CPC
Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General
F41H 7/044 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172934 McAllister et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Sandra S. McAllister (Boston, Massachusetts);  Jessica F. Olive (Worcester, Massachusetts)
ABSTRACT Clonally derived barcoded cell populations and methods of generating the same, as well as methods of use thereof, e.g., to evaluate heterogeneity of a starting population of cells.
FILED Friday, December 11, 2020
APPL NO 17/119245
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5011 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173074 Sahin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) US Govt as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S) Cenk Sahin (Oakwood, Ohio);  Patrick McCormick (Fairborn, Ohio);  Justin Metcalf (Norman, Oklahoma)
ABSTRACT Multi-function waveforms possessing simultaneous radar and communication capabilities provide the means with which to efficiently combat congestion of the spectrum. Here a joint coding/spatial diversity radar/communication waveform design approach is introduced for use with digital antenna arrays. The proposed approach combines the recently developed phase-attached radar/communication (PARC) approach with the far-field radiated emission design (FFRED) formulation to realize the transmission of multiple independent data streams in arbitrary spatial directions concurrently with active radar sensing that is minimally impacted. The resulting physical signals emitted from the elements of the multiple-input multiple-output (MIMO) array have a desirable structure that is constant-modulus and have improved spectral containment relative to the original FFRED formulation.
FILED Wednesday, December 02, 2020
APPL NO 17/109635
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 13/87 (20130101) Original (OR) Class

Antennas, i.e Radio Aerials
H01Q 3/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173195 Hillman
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Elizabeth M.C. Hillman (New York, New York)
ABSTRACT Methods, devices and systems for up to three-dimensional scanning of target regions at high magnification are disclosed.
FILED Wednesday, September 30, 2020
APPL NO 17/038902
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/0032 (20130101)
G02B 21/0052 (20130101)
G02B 21/361 (20130101)
G02B 21/367 (20130101) Original (OR) Class
G02B 23/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173623 Henretty et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Reservoir Labs, Inc. (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Thomas Henretty (Brooklyn, New York);  Richard A. Lethin (New York, New York);  Benoit J. Meister (New York, New York)
ABSTRACT In a sequence of major computational steps or in an iterative computation, a stencil amplifier can increase the number of data elements accessed from one or more data structures in a single major step or iteration, thereby decreasing the total number of computations and/or communication operations in the overall sequence or the iterative computation. Stencil amplification, which can be optimized according to a specified parameter such as compile time, rune time, code size, etc., can improve the performance of a computing system executing the sequence or the iterative computation in terms of run time, memory load, energy consumption, etc. The stencil amplifier typically determines boundaries, to avoid erroneously accessing data elements not present in the one or more data structures.
FILED Monday, July 13, 2020
APPL NO 16/927016
CURRENT CPC
Electric Digital Data Processing
G06F 8/4434 (20130101)
G06F 8/4441 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210174504 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  Louis Stokes Cleveland Veterans Administration Medical Center (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Nathaniel Braman (Bethel Park, Pennsylvania);  Tristan Maidment (Cleveland, Ohio);  Yijiang Chen (Cleveland, Ohio)
ABSTRACT Embodiments discussed herein facilitate determination of whether lesions are benign or malignant. One example embodiment is a method, comprising: accessing medical imaging scan(s) that are each associated with distinct angle(s) and each comprise a segmented region of interest (ROI) of that medical imaging scan comprising a lesion associated with a first region and a second region; providing the first region(s) of the medical imaging scan(s) to trained first deep learning (DL) model(s) of an ensemble and the second region(s) of the medical imaging scan(s) to trained second DL model(s) of the ensemble; and receiving, from the ensemble of DL models, an indication of whether the lesion is a benign architectural distortion (AD) or a malignant AD.
FILED Wednesday, December 09, 2020
APPL NO 17/116366
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 6/025 (20130101)
A61B 6/469 (20130101)
A61B 6/502 (20130101)
A61B 6/5217 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6256 (20130101)
G06K 2209/05 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/04 (20130101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/0012 (20130101) Original (OR) Class
G06T 2207/10112 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30068 (20130101)
G06T 2207/30096 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 30/40 (20180101)
G16H 50/20 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175057 Cooks et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S) Robert Graham Cooks (West Lafayette, Indiana);  Dalton Snyder (West Lafayette, Indiana)
ABSTRACT The invention generally relates to systems and methods for performing multiple precursor, neutral loss and product ion scans in a single ion trap. In certain aspects, the invention provides systems including a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply at least one of the following ion scans to a single ion population in the single ion trap: multiple precursor ion scans, a plurality of segmented neutral loss scans, or multiple simultaneous neutral loss scans.
FILED Wednesday, January 27, 2021
APPL NO 17/159407
CURRENT CPC
Electric Discharge Tubes or Discharge Lamps
H01J 49/004 (20130101)
H01J 49/0013 (20130101)
H01J 49/0027 (20130101) Original (OR) Class
H01J 49/0081 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175335 Dao et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Nanyang Technological University (Singapore, Singapore)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Nanyang Technological University (Singapore, Singapore)
INVENTOR(S) Ming Dao (West Roxbury, Massachusetts);  Ju Li (Weston, Massachusetts);  Zhe Shi (Cambridge, Massachusetts);  Subra Suresh (Wellesley, Massachusetts)
ABSTRACT Compositions and methods related to straining defect doped materials as well as their methods of use in electrical circuits are generally described.
FILED Friday, September 27, 2019
APPL NO 16/585308
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 29/24 (20130101)
H01L 29/36 (20130101) Original (OR) Class
H01L 29/167 (20130101)
H01L 29/207 (20130101)
H01L 29/1602 (20130101)
H01L 29/2003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175962 LI et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
United States Air Force (USAF)
APPLICANT(S) INTELLIGENT FUSION TECHNOLOGY, INC. (Germantown, Maryland)
ASSIGNEE(S)
INVENTOR(S) Lun LI (Germantown, Maryland);  Jingyang LU (Germantown, Maryland);  John NGUYEN (Germantown, Maryland);  Dan SHEN (Germantown, Maryland);  Khanh PHAM (Kirtland AFB, New Mexico);  Genshe CHEN (Germantown, Maryland)
ABSTRACT The present disclosure provides a high power amplifier (HPA) linearization method, applied to a ground hub which includes a predistorter and a PD controller. The ground hub is arranged in a satellite communication system together with a transmitter and a satellite transponder, and the satellite transponder includes an HPA. The HPA linearization method includes determining an initial correction signal based on a physical model with a plurality of PD parameters to compensate AM-AM and AM-PM characteristics of the HPA; receiving a signal from the satellite transponder; determining a reward function for an action taken by the PD controller; examining an action-value function for actions taken in a preset past period; taking an action to adjust the plurality of PD parameters for the PD to generate an updated correction signal; sending the update correction signal to the transmitter to compensate the AM-AM and AM-PM characteristics of the HPA.
FILED Monday, December 09, 2019
APPL NO 16/707927
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Amplifiers
H03F 3/189 (20130101)
H03F 2200/451 (20130101)

Transmission
H04B 7/18513 (20130101)
H04B 7/18519 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210176260 Pan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) Xiaorui Pan (San Jose, California);  Xiaokui Shu (Ossining, New York);  Dhilung Hang Kirat (White Plains, New York);  Jiyong Jang (White Plains, New York);  Marc Philippe Stoecklin (White Plains, New York)
ABSTRACT An automated technique for security monitoring leverages a labeled semi-directed temporal graph derived from system-generated events. The temporal graph is mined to derive process-centric subgraphs, with each subgraph consisting of events related to a process. The subgraphs are then processed to identify atomic operations shared by the processes, wherein an atomic operation comprises a sequence of system-generated events that provide an objective context of interest. The temporal graph is then reconstructed by substituting the identified atomic operations derived from the subgraphs for the edges in the original temporal graph, thereby generating a reconstructed temporal graph. Using graph embedding, the reconstructed graph is converted into a representation suitable for further machine learning, e.g., using a deep neural network. The network is then trained to learn the intention underlying the temporal graph. The approach operates to understand running behavior of programs, to classify them, and then enable detection of potential malicious behaviors.
FILED Monday, December 09, 2019
APPL NO 16/706926
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/04 (20130101)
G06N 3/08 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/1416 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20210169082 Reynolds et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Colorado State University Research Foundation (Fort Collins, Colorado)
ASSIGNEE(S)
INVENTOR(S) Melissa M. Reynolds (Fort Collins, Colorado);  Megan J. Neufeld (Portland, Oregon);  Bella H. Neufeld (Fort Collins, Colorado);  Alec Lutzke (Fort Collins, Colorado)
ABSTRACT A substrate having an antibacterial surface includes a chitosan matrix and water-stable metal-organic frameworks dispersed throughout the chitosan matrix. The water-stable metal-organic frame-works are present in an amount of 5% wt/wt to 20% wt/wt based on total solids of the substrate
FILED Wednesday, July 11, 2018
APPL NO 16/630264
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 25/10 (20130101)
A01N 55/02 (20130101) Original (OR) Class

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 2/18 (20130101)
A61L 2/23 (20130101)
A61L 2101/34 (20200801)

Polysaccharides; Derivatives Thereof
C08B 37/003 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/56 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169321 FINK et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) WOLFGANG FINK (TUCSON, Arizona);  MARK TARBELL (TUCSON, Arizona)
ABSTRACT Various examples of methods, systems and devices are provided for ophthalmic examination. In one example, a handheld system includes an optical imaging assembly coupled to a user device that includes a camera aligned with optics of the optical imaging assembly. The user device can obtain ocular imaging data of at least a portion of an eye via the optics of the optical imaging assembly and provide ophthalmic evaluation results based at least in part upon the ocular imaging data. In another example, a method includes receiving ocular imaging data of at least a portion of an eye; analyzing the ocular imaging data to determine at least one ophthalmic characteristic of the eye; and determining a condition based at least in part upon the at least one ophthalmic characteristic.
FILED Monday, November 23, 2020
APPL NO 17/101503
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 3/0008 (20130101)
A61B 3/12 (20130101) Original (OR) Class
A61B 3/14 (20130101)
A61B 3/0033 (20130101)
A61B 3/0041 (20130101)
A61B 3/135 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169419 OREN et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S)
INVENTOR(S) SEVAL OREN (Eskisehir, Turkey);  Liang Dong (Ames, Iowa)
ABSTRACT Methods, systems, and apparatus for high-resolution patterning of various substrates with functional materials, including nanomaterials. A technique of preparing a patterned substrate in a high-resolution mold for stick and transfer process is disclosed with promotes integrity of the high-resolution pattern onto the substrate. One example of a substrate is an adhesive tape. The transferred pattern(s) are scalable and can be implemented in different fabrication processes. One example is a roll-to-roll processes. In one embodiment, the transferred pattern comprises nanomaterials and the substrate comprises a flexible substrate for use in flexible and conformal assemblies for a wide variety of applications including, but not limited to, electrical-based sensors on non-planar inanimate surfaces, plant body surface, or human or animal skin.
FILED Monday, November 30, 2020
APPL NO 17/247112
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/01 (20130101)
A61B 5/002 (20130101)
A61B 5/1126 (20130101)
A61B 5/4266 (20130101)
A61B 5/6804 (20130101)
A61B 5/6806 (20130101)
A61B 5/6832 (20130101) Original (OR) Class
A61B 2503/40 (20130101)
A61B 2562/125 (20130101)
A61B 2562/0247 (20130101)
A61B 2562/0261 (20130101)
A61B 2562/0285 (20130101)

Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 7/12 (20130101)
B32B 9/041 (20130101)
B32B 9/045 (20130101)
B32B 37/12 (20130101)
B32B 37/025 (20130101)
B32B 2457/00 (20130101)

Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 1/205 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/0098 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169559 Li et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Wei Li (Austin, Texas);  Xiaoran Li (Austin, Texas)
ABSTRACT The present invention provides devices and methods for improved tissue hemostasis and electrosurgery. The devices and methods are based on measuring acoustic signals near an electrosurgery site to determine when sufficient hemostasis is achieved. The devices include cautery devices and systems incorporating acoustic sensors and acoustic signal software.
FILED Friday, December 04, 2020
APPL NO 17/112337
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 18/20 (20130101)
A61B 18/1445 (20130101) Original (OR) Class
A61B 18/1815 (20130101)
A61B 2018/00577 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169694 HUMAYUN et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S)
INVENTOR(S) Mark S. HUMAYUN (Glendale, California);  Aldo OREGON (Los Angeles, California);  Yi ZHANG (Los Angeles, California)
ABSTRACT Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.
FILED Monday, November 23, 2020
APPL NO 17/102078
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 9/00727 (20130101) Original (OR) Class

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/18 (20130101)
A61L 27/24 (20130101)
A61L 27/222 (20130101)
A61L 27/225 (20130101)
A61L 27/227 (20130101)
A61L 2430/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210169992 Haigis et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Marcia C. Haigis (Winchester, Massachusetts);  Giulia Notarangelo (Cambridge, Massachusetts)
ABSTRACT Provided herein are methods and compositions for treating cancer in a subject by administering an agent that inhibits the activity of or decreases the levels of D-2hydroxyglutarate (D-2HG).
FILED Wednesday, November 18, 2020
APPL NO 16/951161
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/194 (20130101)
A61K 38/443 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1137 (20130101)
C12N 2310/14 (20130101)
C12N 2310/141 (20130101)
C12N 2310/531 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170054 QIN et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Andreas Zumbuehl (Bern, Switzerland);  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S) Board of Regents, the University of Texas System (Austin, Texas)
INVENTOR(S) Zhenpeng QIN (Richerdson, Texas);  Xiuying LI (Richerdson, Texas);  Frederik NEUHAUS (Fribourg, Switzerland);  Andreas ZUMBUEHL (Fribourg, Switzerland);  Hejian XIONG (Richardson, Texas)
ABSTRACT In some aspects, the present disclosure provides mechanosensitive vesicles, which are light sensitive for delivery of a guest molecule. In some embodiments, these vesicles include mechanosensitive phospholipids which have been coated with a noble metal coating.
FILED Monday, April 15, 2019
APPL NO 17/046385
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/1271 (20130101)
A61K 41/0028 (20130101)
A61K 49/0041 (20130101)
A61K 49/0084 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170074 ANIKEEVA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Polina Olegovna ANIKEEVA (Somerville, Massachusetts);  Dena Shahriari (Boston, Massachusetts);  Yoel FINK (Brookline, Massachusetts);  Zi Jie Gabriel Loke (Cambridge, Massachusetts);  Ian James Tafel (Jamaica Plain, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Polina Olegovna ANIKEEVA (Somerville, Massachusetts);  Dena Shahriari (Boston, Massachusetts);  Yoel FINK (Brookline, Massachusetts);  Zi Jie Gabriel Loke (Cambridge, Massachusetts);  Ian James Tafel (Jamaica Plain, Massachusetts)
ABSTRACT Methods for generating porous scaffolds may include tuning a porogen/crystallite's particle size to a desired range and mixing the crystallite particles with a polymer solution. The mixture is then cast to form films. The films are rolled and consolidated around another inner material to create a preform, which is then thermally drawn. The inner material and the porogen can be selectively removed to obtain porous constructs/fibers. The structures can be fuse-printed to produce complex tissue scaffolds with dimensions up to several centimeters and beyond.
FILED Tuesday, November 26, 2019
APPL NO 16/695932
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/16 (20130101)
A61L 27/26 (20130101)
A61L 27/56 (20130101) Original (OR) Class
A61L 27/3675 (20130101)
A61L 27/3687 (20130101)
A61L 27/3691 (20130101)
A61L 2430/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170594 Kuo et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Yen-Ling Kuo (Cambridge, Massachusetts);  Boris Katz (Cambridge, Massachusetts);  Andrei Barbu (Cambridge, Massachusetts)
ABSTRACT The present approach similarly combines task and motion planning, but does so without symbolic representations and begins with simpler tasks than other models in such domains can handle. Unlike prior approaches, the present approach does so in continuous action and state spaces which require many precise steps in the configuration space to execute what otherwise is a single output token such as “pick up” for discrete problems.
FILED Friday, December 04, 2020
APPL NO 17/112699
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/1664 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)
G06N 3/0427 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170670 Barr et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Science Foundation (NSF)
APPLICANT(S) HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
ASSIGNEE(S) HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
INVENTOR(S) Christian G. Barr (Kansas City, Missouri);  George W. Bohnert (Harrisonville, Missouri)
ABSTRACT Methods and assemblies for additive manufacturing portions of components with enhanced strength are provided. The assemblies comprise a first deposition head and an apparatus for causing one or more reinforcement fibers to extend more than two layers within previously-deposited layers of build material. The first deposition head is configured to deposit a plurality of layers of a filament comprising a reinforcement fiber and thermoplastic material. The apparatus may comprise a needle point configured to be inserted into the plurality of layers to displace the reinforcement fiber so that it extends two or more of the plurality of layers. The apparatus may additionally or alternatively comprise a second deposition head having a needle tip configured to be inserted into the plurality of layers to inject a length of a second filament comprising thermoplastic material and a reinforcement fiber so that the reinforcement fiber of the second filament extends two or more layers of the plurality of layers of the first filament.
FILED Friday, December 06, 2019
APPL NO 16/705363
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801) Original (OR) Class
B29C 64/188 (20170801)
B29C 64/209 (20170801)
B29C 64/227 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171345 MARKER et al.
FUNDED BY
Department of Energy (DOE)
National Science Foundation (NSF)
APPLICANT(S) Gas Technology Institute (Des Plaines, Illinois)
ASSIGNEE(S)
INVENTOR(S) Terry MARKER (Park Ridge, Illinois);  Martin B. LINCK (Wilmette, Illinois);  Jim WANGEROW (Oak Park, Illinois);  Pedro ORTIZ-TORAL (Wheeling, Illinois)
ABSTRACT Processes for converting methane and/or other hydrocarbons to synthesis gas (i.e., a gaseous mixture comprising H2 and CO) are disclosed, in which at least a portion of the hydrocarbon(s) is reacted with CO2. At least a second portion of the methane may be reacted with H2O (steam), thereby improving overall thermodynamics of the process, in terms of reducing endothermicity (AH) and the required energy input, compared to “pure” dry reforming in which no H2O is present. Catalysts for such processes advantageously possess high activity and thereby can achieve significant levels of methane conversion at temperatures below those used conventionally under comparable conditions. These catalysts also exhibit high sulfur tolerance, in addition to reduced rates of carbon (coke) formation, even in the processing (reforming) of heavier (e.g., naphtha boiling-range or jet fuel boiling-range) hydrocarbons. The robustness of the catalyst translates to high operating stability. A representative catalyst comprises 1 wt-% Pt and 1 wt-% Rh as noble metals, on a cerium oxide support.
FILED Wednesday, January 20, 2021
APPL NO 17/153375
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 23/10 (20130101)
B01J 23/63 (20130101)
B01J 23/6567 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 3/40 (20130101) Original (OR) Class
C01B 2203/043 (20130101)
C01B 2203/107 (20130101)
C01B 2203/0233 (20130101)
C01B 2203/0238 (20130101)
C01B 2203/0283 (20130101)
C01B 2203/0405 (20130101)
C01B 2203/1064 (20130101)
C01B 2203/1082 (20130101)
C01B 2203/1241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171393 CHEN et al.
FUNDED BY
Department of Energy (DOE)
National Science Foundation (NSF)
APPLICANT(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania);  DEPT. OF ENERGY (Pittsburgh, Pennsylvania)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTBURGH, Pennsylvania);  DEPT. OF ENERGY (PITTSBURGH, Pennsylvania)
INVENTOR(S) PENG CHEN (PITTSBURGH, Pennsylvania);  JACOB LORENZI POOLE (Pittsburgh, Pennsylvania);  PAUL R. OHODNICKI (ALLISON PARK, Pennsylvania);  MICHAEL PAUL BURIC (PITTSBURGH, Pennsylvania)
ABSTRACT An optical sensor device includes a multilayer hollow waveguide device having a hollow waveguide tube layer, an intermediate layer provided inside the hollow waveguide tube layer, and a metal oxide coating layer inside the intermediate layer.
FILED Wednesday, January 13, 2021
APPL NO 17/148298
CURRENT CPC
Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials
C03C 25/106 (20130101) Original (OR) Class
C03C 25/1061 (20180101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/05 (20130101)
G01N 21/553 (20130101)
G01N 21/774 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171473 ARORA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Eye Institute (NEI)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Paramjit S. ARORA (Cold Spring Harbor, New York);  Brooke Bullock LAO (Leesville, South Carolina);  Richard BONNEAU (New York, New York);  Kevin DREW (Austin, Texas)
ABSTRACT The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
FILED Monday, August 03, 2020
APPL NO 16/984041
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 29/80 (20130101)
C07C 29/88 (20130101)

Heterocyclic Compounds
C07D 241/08 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171665 Schneiderman et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) NANOPAREIL, LLC (Dakota Dunes, South Dakota)
ASSIGNEE(S)
INVENTOR(S) Steven Schneiderman (Dakota Dunes, South Dakota);  Todd J. Menkhaus (Dakota Dunes, South Dakota);  Yong Zhao (Dakota Dunes, South Dakota);  Hao Fong (Dakota Dunes, South Dakota);  Craig Arnold (Dakota Dunes, South Dakota)
ABSTRACT The invention relates to porous polymeric cellulose prepared via cellulose crosslinking. The porous polymeric cellulose can be incorporated into membranes and/or hydrogels. In preferred embodiments, the membranes and/or hydrogels can provide high dynamic binding capacity at high flow rates. Membranes and/or hydrogels comprising the porous polymeric cellulose are particularly suitable for filtration, separation, and/or functionalization media.
FILED Friday, February 12, 2021
APPL NO 17/248915
CURRENT CPC
Separation
B01D 61/38 (20130101)
B01D 67/0093 (20130101)
B01D 69/02 (20130101)
B01D 69/125 (20130101)
B01D 71/10 (20130101)
B01D 2323/08 (20130101)
B01D 2323/30 (20130101)
B01D 2323/36 (20130101)
B01D 2325/06 (20130101)
B01D 2325/14 (20130101)
B01D 2325/16 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/267 (20130101)
B01J 20/2808 (20130101)
B01J 20/28007 (20130101)
B01J 20/28038 (20130101)
B01J 2220/52 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)

Polysaccharides; Derivatives Thereof
C08B 15/10 (20130101) Original (OR) Class

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/2275 (20130101)
C08J 2301/02 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/092 (20130101)

Compositions of Macromolecular Compounds
C08L 1/02 (20130101)

Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials
D06M 13/21 (20130101)
D06M 13/33 (20130101)
D06M 13/192 (20130101)
D06M 2101/06 (20130101)
D06M 2101/28 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171673 Altenberg et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Texas Tech University System (Lubbock, Texas)
ASSIGNEE(S)
INVENTOR(S) Guillermo A. Altenberg (Lubbock, Texas);  Hongjun Liang (Lubbock, Texas)
ABSTRACT The present invention includes compositions, methods, and methods of making and using a polymer-encased nanodisc comprising: one or more integral membrane proteins in a lipid layer; and a polymer comprising zwitterionic styrene-maleic acid derivative repeating units that carry zero or nearly zero negative charge, and the polymer-encased nanodiscs.
FILED Wednesday, October 07, 2020
APPL NO 17/064687
CURRENT CPC
Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 2/38 (20130101)
C08F 8/12 (20130101)
C08F 8/40 (20130101) Original (OR) Class
C08F 8/44 (20130101)
C08F 222/08 (20130101)
C08F 2438/03 (20130101)

Compositions of Macromolecular Compounds
C08L 33/00 (20130101)
C08L 89/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/14 (20130101)
C12N 9/96 (20130101)
C12N 11/04 (20130101)
C12N 11/08 (20130101)

Enzymes
C12Y 306/01003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171704 Michl et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Army Research Office (ARO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
INVENTOR(S) Josef Michl (Boulder, Colorado);  Thomas Frank Magnera (Boulder, Colorado)
ABSTRACT Methods of forming a porphene polymeric material are provided. The resulting material can be a porphene or a metalloporphene polymeric material. The structure of the polymer can be selected based on a material provided in the monomer material. Methods of using the polymeric material are also provided.
FILED Friday, December 04, 2020
APPL NO 17/112865
CURRENT CPC
Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 61/122 (20130101) Original (OR) Class
C08G 85/004 (20130101)
C08G 2261/40 (20130101)
C08G 2261/374 (20130101)
C08G 2261/376 (20130101)
C08G 2261/3241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171720 WEBSTER et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) NDSU RESEARCH FOUNDATION (Fargo, North Dakota)
ASSIGNEE(S) NDSU RESEARCH FOUNDATION (Fargo, North Dakota)
INVENTOR(S) Dean C. WEBSTER (Fargo, North Dakota);  Eric M. KRALL (Minneapolis, Minnesota);  Kelly M. SUTKO (N. Maple Grove, Minnesota);  Alexander T. HART (Farmington, Minnesota);  Karan BANSAL (Fargo, North Dakota);  Mohiuddin QUADIR (West Fargo, North Dakota)
ABSTRACT The invention relates to acetoacetylated lignin resin compositions comprising the reaction product of lignin and an acetoacetate ester. The invention also relates to (meth)acrylated lignin resin compositions comprising the reaction product of lignin and a (meth)acrylic compound. The invention also relates to methods of making the acetoacetylated and (meth)acrylated lignin resin compositions. The invention also relates to curable coating compositions comprising the acetoacetylated and (meth)acrylated lignin resin compositions. The invention also relates to methods of making the curable coating compositions of the invention. The invention also relates to methods of applying curable coating compositions of the invention to substrates. The invention also relates to articles of manufacture comprising a curable coating composition of the invention and a method of making such article. The invention also relates to foam materials comprising the reaction product of an acetoacetylated resin composition, a polyamine compound, and a physical blowing agent and/or a polysiloxane compound.
FILED Monday, November 30, 2020
APPL NO 17/106866
CURRENT CPC
Derivatives of Natural Macromolecular Compounds
C08H 6/00 (20130101) Original (OR) Class

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 9/141 (20130101)
C08J 2203/14 (20130101)
C08J 2397/00 (20130101)
C08J 2483/04 (20130101)

Compositions of Macromolecular Compounds
C08L 97/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171727 BAE
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
National Science Foundation (NSF)
APPLICANT(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
ASSIGNEE(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
INVENTOR(S) Chulsung BAE (Cohoes, New York)
ABSTRACT The electrochemical energy conversion system include an anode, a cathode, and a proton exchange membrane disposed between the anode and the cathode. The proton exchange membrane includes a polymer having a hard block polymer, a soft block polymer, and one or more hydrophilic functional groups attached to the soft block polymer. The glass transition temperature of the hard block polymer is higher than a glass transition temperature of the soft block polymer, such that the hard block polymer is non-elastic and the soft block polymer is elastic at a desired operating temperature. The hydrophilic functional groups are attached to the soft block polymer via a thiol-ene reaction to modify double bonds in the soft block polymer. The swellable functional groups are selectively connected to the soft domains of the block copolymers, so that when the membrane swells (under hydration or gas adsorption), the stress is effectively absorbed by the soft domain and the impact on overall mechanical properties is minor, resulting in more durable membranes.
FILED Thursday, December 06, 2018
APPL NO 16/770666
CURRENT CPC
Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 8/04 (20130101)
C08F 8/06 (20130101)
C08F 8/36 (20130101)
C08F 36/06 (20130101)
C08F 36/08 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/2231 (20130101) Original (OR) Class

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/37 (20130101)

Compositions of Macromolecular Compounds
C08L 25/08 (20130101)
C08L 53/025 (20130101)
C08L 65/02 (20130101)
C08L 71/12 (20130101)
C08L 81/06 (20130101)
C08L 2312/00 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 8/1023 (20130101)
H01M 8/1072 (20130101)
H01M 8/1088 (20130101)
H01M 2008/1095 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171753 Marks et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Tobin J. Marks (Evanston, Illinois);  Minglu Huang (Evanston, Illinois);  Yanshan Gao (Evanston, Illinois)
ABSTRACT Methods for forming polar-functionalized isotactic and syndiotactic polypropylenes are provided, including amino-functionalized polypropylene. In embodiments, such a method comprises contacting a propylene monomer and a polar monomer comprising an amine group in the presence of an organozirconium catalyst and in the absence of a masking reagent, under conditions to induce a polymerization reaction between the propylene and polar monomers, thereby forming polar-functionalized polypropylene.
FILED Friday, December 04, 2020
APPL NO 17/111682
CURRENT CPC
Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 4/52 (20130101)
C08F 4/76 (20130101)

Compositions of Macromolecular Compounds
C08L 23/36 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171931 Peterson et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Worcester Polytechnic Institute (Worcester, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Amy Peterson (Cambridge, Massachusetts);  Marsha Rolle (Worcester, Massachusetts);  Ivan Ding (Mays Landing, New Jersey)
ABSTRACT Device, and methods of using or making the device, for engineering cells in vitro are disclosed. In some aspects, a cell culture device comprises at least one glass or polymer surface configured for incubating cells in a culture medium; a charged molecule electrostatically bound to the surface; and a polyelectrolyte multilayer (PEM) electrostatically bound to the charged molecule, the PEM comprising one or more bi-layers of oppositely charged polyelectrolytes, and the PEM having a sufficient thickness to permit release of the charged molecule into the culture medium in a controlled released manner.
FILED Friday, July 17, 2020
APPL NO 16/931967
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 21/08 (20130101)
C12M 23/20 (20130101)
C12M 25/14 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0068 (20130101)
C12N 13/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171970 Thelen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) Jay Thelen (Columbia, Missouri);  Matthew Salie (Columbia, Missouri)
ASSIGNEE(S) The Curators of The University of Missouri (Columbia, Missouri)
INVENTOR(S) Jay Thelen (Columbia, Missouri);  Matthew Salie (Columbia, Missouri)
ABSTRACT The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the activity levels of the committed step for de novo fatty acid biosynthesis, acetyl-CoA carboxylases (ACCase). More specifically, methods of the invention directly enhance the activity of ACCase by down-regulating the biotin/lipoyl attachment domain containing (BADC) genes through biotechnology or selective breeding approaches.
FILED Wednesday, November 04, 2020
APPL NO 17/089241
CURRENT CPC
Peptides
C07K 14/415 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/93 (20130101)
C12N 15/87 (20130101)
C12N 15/113 (20130101)
C12N 15/8247 (20130101) Original (OR) Class
C12N 2310/14 (20130101)

Enzymes
C12Y 604/01 (20130101)
C12Y 604/01002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172017 Jin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Mental Health (NIMH)
National Science Foundation (NSF)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Xin Jin (Cambridge, Massachusetts);  Paola Arlotta (Cambridge, Massachusetts);  Aviv Regev (Cambridge, Massachusetts);  Feng Zhang (Cambridge, Massachusetts);  Sean Simmons (Cambridge, Massachusetts)
ABSTRACT Described herein are methods and uses thereof for in vivo evaluating functions of multiple genes in parallel by combining in utero genetic perturbation of progenitor cells and single-cell transcriptomic profiling of progeny cells in animals. These methods can be used, among other things, to reveal in vivo gene functions in a cell type-specific manner.
FILED Friday, January 29, 2021
APPL NO 17/163015
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/907 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 1/6897 (20130101)
C12Q 2600/136 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172087 Hone et al.
FUNDED BY
Department of Energy (DOE)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
INVENTOR(S) James Hone (New York, New York);  Fang Liu (New York, New York);  Xiaoyang Zhu (New York, New York);  Sang Hoon Chae (New York, New York)
ABSTRACT Systems and methods for generating one or more single crystal monolayers from two-dimensional van der Waals crystals are disclosed herein. Example methods include providing a bulk material including a plurality of van der Waals crystal layers, and exfoliating one or more single crystal monolayers of van der Waals crystal from the bulk material by applying a flexible and flat metal tape to a surface of the bulk material. In certain embodiments, the one or more single crystal monolayers can be assembled into an artificial lattice. The present disclosure also provides techniques for manufacturing flexible and flat metal tape for generating one or more single crystal monolayers from two-dimensional van der Waals crystals. The present disclosure also provides compositions for creating a macroscopic artificial lattice. In certain embodiments, the composition can include two or more macroscopic single crystal monolayers adapted from a bulk van der Waals crystal, where the single crystal monolayers are configured for assembly into an artificial lattice based on one or more properties.
FILED Wednesday, November 25, 2020
APPL NO 17/105105
CURRENT CPC
Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 7/02 (20130101)
B32B 18/00 (20130101)
B32B 37/18 (20130101)
B32B 37/025 (20130101)
B32B 43/006 (20130101)
B32B 2315/02 (20130101)

Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/16 (20130101)
C23C 14/30 (20130101)

Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 29/46 (20130101)
C30B 29/68 (20130101)
C30B 33/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172460 Keplinger et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Army Research Office (ARO)
National Aeronautics and Space Administration (NASA)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S) Christoph Matthias Keplinger (Gerlinger, Germany);  Xingrui Wang (Stuttgart, Germany);  Shane Karl Mitchell (Denver, Colorado)
ABSTRACT High strain hydraulically amplified self-healing electrostatic transducers having increased maximum theoretical and practical strains are disclosed. In particular, the actuators include electrode configurations having a zipping front created by the attraction of the electrodes that is configured orthogonally to a strain axis along which the actuators. This configuration produces increased strains. In turn, various form factors for the actuator configuration are presented including an artificial circular muscle and a strain amplifying pulley system. Other actuator configurations are contemplated that include independent and opposed electrode pairs to create cyclic activation, hybrid electrode configurations, and use of strain limiting layers for controlled deflection of the actuator.
FILED Thursday, December 10, 2020
APPL NO 17/117418
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/1075 (20130101)

Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for
F15B 5/006 (20130101) Original (OR) Class
F15B 15/103 (20130101)
F15B 21/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172844 JACKSON et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) CELLULA ROBOTICS, LTD. (Burnaby, Canada)
ASSIGNEE(S)
INVENTOR(S) James Eric JACKSON (New Westminster, Canada);  Don R. CLARKE (Trail, Canada);  Arthur TREMBANIS (Newark, Delaware);  Craig CARY (Hillcrest, New Zealand)
ABSTRACT A sample collector includes a hollow sleeve and a removable sampler assembly within the sleeve. The sampler assembly includes a filter assembly including a filter element for filtering at least one material. The sampler assembly includes a first cover including a first sealing member to seal a first end of the filter assembly in the sleeve, and a second cover including a second sealing member to seal a second end of the filter assembly in the sleeve.
FILED Friday, February 17, 2017
APPL NO 16/077934
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/10 (20130101)
G01N 1/4077 (20130101) Original (OR) Class
G01N 2001/4088 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172928 Burden et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) THE TRUSTEES OF WHEATON COLLEGE (Wheaton, Illinois)
ASSIGNEE(S)
INVENTOR(S) Daniel L. Burden (Wheaton, Illinois);  Lisa M. Burden (Wheaton, Illinois)
ABSTRACT The present disclosure relates to membranes having enhanced stability and durability, methods of making the same, and uses thereof. Membranes of the disclosure are useful in technologies that depend on a lipid bilayer for success, e.g., nanopore sensing applications. The stability of the membrane is enhanced by attaching a filamentous network to the membrane, such as a network of actin microfilament protein.
FILED Friday, May 03, 2019
APPL NO 17/047939
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502707 (20130101)
B01L 3/502761 (20130101)
B01L 2200/12 (20130101)
B01L 2200/0652 (20130101)
B01L 2300/12 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5308 (20130101)
G01N 33/48721 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172957 Chiu
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Daniel T. Chiu (Seattle, Washington)
ABSTRACT Methods, systems, compositions and kits are provided for the analysis of target molecules using chromophoric polymer dots conjugated to biomolecules. The use of chromophoric polymer dots improves detection sensitivity and stability when compared with existing techniques. In some aspects, methods, systems, and kits are provided for detecting a target protein using chromophoric polymer dots conjugated to biomolecules in a Western blot analysis. Related methods, systems, compositions and kits are also provided.
FILED Friday, February 12, 2021
APPL NO 17/175408
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/588 (20130101) Original (OR) Class
G01N 33/6803 (20130101)
G01N 2458/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173021 Dubroca et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
Division of Materials Research (DMR)
APPLICANT(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S)
INVENTOR(S) Thierry Dubroca (Tallahassee, Florida);  Bianca Trociewitz (Tallahassee, Florida);  Johannes McKay (Tallahassee, Florida);  Frederic Mentink-Vigier (Tallahassee, Florida)
ABSTRACT Apparatuses and methods for removing caps, such as NMR rotor caps. The apparatuses and methods may permit caps to be removed in a manner that minimizes damage to equipment and instruments. Microwave waveguides that may include an elongated waveguide, a spline horn, and a slotted waveguide. Analytical instruments that include the waveguides.
FILED Wednesday, November 25, 2020
APPL NO 17/104057
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/307 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173195 Hillman
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Elizabeth M.C. Hillman (New York, New York)
ABSTRACT Methods, devices and systems for up to three-dimensional scanning of target regions at high magnification are disclosed.
FILED Wednesday, September 30, 2020
APPL NO 17/038902
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/0032 (20130101)
G02B 21/0052 (20130101)
G02B 21/361 (20130101)
G02B 21/367 (20130101) Original (OR) Class
G02B 23/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173963 Alaql et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Abdulrahman Alaql (Gainesville, Florida);  Saranyu Chattopadhyay (Gainesville, Florida);  Swarup Bhunia (Gainesville, Florida);  Prabuddha Chakraborty (Gainesville, Florida)
ABSTRACT Embodiments of the present disclosure provide methods, apparatus, systems, computer program products, computing devices, and/or computing entities for obfuscating a hardware intellectual property (IP) design by locking the design based at least in part on a plurality of key-bits. In one embodiment, a method is provided comprising: generating a key vulnerability matrix for a locked version of the design and a plurality of attacks that comprises for each attack, a vector comprising a value for each key-bit identifying whether the attack successfully extracted a correct key value for the key-bit; and for each key-bit: determining whether the key-bit is vulnerable to an attack based on the values in the matrix; and responsive to being vulnerable: identifying a set of solutions to mitigate the attack; selecting a solution from the set; and inserting a key-gate type for the key-bit at a location identified by the selected solution into the design.
FILED Monday, November 23, 2020
APPL NO 17/101153
CURRENT CPC
Electric Digital Data Processing
G06F 21/75 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210174029 NARAYANAN et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) UNIVERSITY OF SOUTHERN CALIFORNIA (LOS ANGELES, California)
ASSIGNEE(S)
INVENTOR(S) SHRIKANTH NARAYANAN (LOS ANGELES, California);  VICTOR MARTINEZ PALACIOS (LOS ANGELES, California);  ANIL RAMAKRISHNA (LOS ANGELES, California);  KRISHNA SOMANDEPALLI (LOS ANGELES, California);  NIKOLAOS MALANDRAKIS (LOS ANGELES, California);  KARAN SINGLA (LOS ANGELES, California)
ABSTRACT A computer implemented method for analyzing media content includes a step of providing a plurality of narrative files formatted in human readable format. Each narrative file includes a script and/or dialogues tagged with character names along with auxiliary information. Each script includes a plurality of portrayals performed by an associated actor or character. Linguistic representations of content of the narrative files in both abstract and semantic forms is determined. The linguistic representations are connected to higher order representations and mental states. The linguistic representations are connected to behavior and action. Interplay between language constructs and demographics of content creators is analyzed. Content representations towards individuals/groups are adapted to reflect heterogeneity in preferences.
FILED Friday, February 19, 2021
APPL NO 17/179960
CURRENT CPC
Electric Digital Data Processing
G06F 16/313 (20190101)
G06F 16/353 (20190101)
G06F 17/18 (20130101)
G06F 40/30 (20200101) Original (OR) Class
G06F 40/169 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210174969 Zupanc et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Gunther Zupanc (Auburndale, Massachusetts);  David Lehotzky (Boston, Massachusetts);  Rifat Sipahi (Brookline, Massachusetts)
ABSTRACT An algorithm is disclosed for computational modeling of stem-cell-driven tissue growth of adult spinal cord tissue. Simulations based on this model can be used for parameter testing and making predictions about the growth dynamics of biological spinal cord tissue. Such predictions include alterations in the growth dynamics and the final properties of the tissue induced by experimental or medical intervention.
FILED Friday, October 30, 2020
APPL NO 17/085210
CURRENT CPC
Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 50/50 (20180101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175185 Kozicki
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Michael Kozicki (Phoenix, Arizona)
ASSIGNEE(S)
INVENTOR(S) Michael Kozicki (Phoenix, Arizona)
ABSTRACT Systems for physical unclonable function (“PUF”) generation, PUF devices, and methods for manufacturing PUF devices. In one implementation, the system includes a plurality of PUF devices and an electronic controller. Each of the plurality of PUF devices include a first electrochemically-inactive electrode, a second electrochemically-inactive electrode, and a layer of silicon suboxide. The layer of silicon suboxide is positioned directly between the first electrochemically-inactive electrode and the second electrochemically-inactive electrode. The electronic controller is communicably coupled to the plurality of PUF devices. The electronic controller is configured to read binary values associated with the plurality of PUF devices.
FILED Friday, December 04, 2020
APPL NO 17/112668
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 23/573 (20130101) Original (OR) Class

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/3278 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175419 SANGWAN et al.
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Office of Emerging Frontiers in Research and Innovation (EFRI)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Vinod K. SANGWAN (Evanston, Illinois);  Hong-Sub LEE (Evanston, Illinois);  Mark C. HERSAM (Wilmette, Illinois)
ABSTRACT One aspect of the invention relates to a multi-terminal memtransistor. The memtransistor includes a substrate having a first surface and an opposite, second surface, a polycrystalline monolayer film formed of an atomically thin material on the first surface of the substrate, an electrode array having a plurality of electrodes spatial-apart formed on the polycrystalline monolayer film such that each pair of electrodes defines a channel in the polycrystalline monolayer film therebetween, and a gate electrode formed on the second surface of the substrate and capacitively coupled with the channel. The polycrystalline monolayer film contains grains defining a plurality of grain boundaries thereof. The multi-terminal memtransistor operates much like a neuron by performing both memory and information processing, and can be a foundational circuit element for new forms of neuromorphic computing.
FILED Monday, December 17, 2018
APPL NO 16/770662
CURRENT CPC
Static Stores
G11C 13/0002 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/2436 (20130101)
H01L 45/145 (20130101)
H01L 45/1206 (20130101) Original (OR) Class
H01L 45/1253 (20130101)
H01L 45/1608 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175878 Galton et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Ian Galton (Del Mar, California);  Enrique Alvarez-Fontecilla (San Diego, California);  Amr Eissa (La Jolla, California)
ABSTRACT A ΔΣ frequency to digital converter includes digital feedback to an accumulator in a ring phase calculator that provides the converter output, which reduces implantation complexity. Digital gain correction is applicable to dual mode ring oscillator converters and charge pump converters, provides compensation for forward path gain error and eliminates the need to include analog gain correction in feedback. Asynchronous sampling includes correction logic to compensate for arbitrary initial conditions. A digitally-controlled oscillator (DCO) control technique causes the DCO frequency to increase or decrease by changing the state of one its frequency control elements at a time.
FILED Wednesday, December 02, 2020
APPL NO 17/109624
CURRENT CPC
Pulse Technique
H03K 3/0315 (20130101) Original (OR) Class

Coding; Decoding; Code Conversion in General
H03M 3/496 (20130101)

Transmission
H04B 1/40 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20210169405 DEMOS
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Stavros DEMOS (Livermore, California)
ABSTRACT The present disclosure relates to a method for visualizing a sub-dermal structure. The method involves illuminating an imaged area of interest (AOI) including sub-dermal regions thereof with near-infrared (NIR) light. The NIR light is passed through a first optical system for controlling at least one of spectral and polarization properties thereof prior to illuminating the imaged AOI. One or more desired optical components of an optical signal reflected back from the imaged area of interest is detected, which represent specific portions of the sub-dermal regions where specific anatomical structure of interest is present. The desired optical components represent a vein visualization signal representing only a portion of the reflected optical signal that falls within a sub-range of intensities, relative to intensities of a remainder of the reflected optical signal. The sub-range of intensities assist in visualizing a vascular structure below a skin layer of a patient. The vein visualization signal may be used to generate a display of the vascular structure on a display system.
FILED Thursday, January 21, 2021
APPL NO 17/154710
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0059 (20130101)
A61B 5/0075 (20130101)
A61B 5/0077 (20130101)
A61B 5/489 (20130101) Original (OR) Class
A61B 5/742 (20130101)
A61B 5/02007 (20130101)
A61B 5/7203 (20130101)
A61B 2562/0233 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170352 Rivest et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency Energy (ARPAE)
APPLICANT(S) Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S) Palo Alto Research Center Incorporated (Palo Alto, California)
INVENTOR(S) Jessica Louis Baker Rivest (Palo Alto, California);  Divyaraj Desai (Hayward, California);  Dane Andrew Boysen (Anchorage, Alaska);  Ashish V. Pattekar (Cupertino, California)
ABSTRACT Methods comprising: evaporating a catalyst source to produce a catalyst gas; condensing the catalyst gas to produce a catalyst vapor comprising catalyst droplets suspended in a gas phase; and contacting the catalyst vapor with a hydrocarbon gas to catalyze a decomposition reaction of the hydrocarbon gas into hydrogen gas and carbon. And, systems comprising: a catalyst source evaporator that provides a first stream to a reactor; a hydrocarbon source that provides a second stream to the reactor; a cooling column coupled to the reactor via a third stream comprising hydrogen, catalyst liquid, solid carbon, optionally catalyst gas, and optionally unreacted hydrocarbon gas such that the cooling column receives the third stream from the reactor; and wherein the cooling column has effluent streams that include (a) a fourth stream that comprises hydrogen and optionally catalyst gas and (b) a fifth stream that comprises catalyst liquid.
FILED Wednesday, September 16, 2020
APPL NO 17/022503
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 6/008 (20130101) Original (OR) Class

Non-metallic Elements; Compounds Thereof;
C01B 3/26 (20130101)
C01B 2203/0277 (20130101)
C01B 2203/0883 (20130101)
C01B 2203/1005 (20130101)
C01B 2203/1241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170387 Rivest et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency Energy (ARPAE)
APPLICANT(S) Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S) Palo Alto Research Center Incorporated (Palo Alto, California)
INVENTOR(S) Jessica Louis Baker Rivest (Palo Alto, California);  Divyaraj Desai (Hayward, California);  Dane Andrew Boysen (Anchorage, Alaska);  Ashish V. Pattekar (Cupertino, California)
ABSTRACT Methods comprising: evaporating a catalyst source to produce a catalyst gas; condensing the catalyst gas to produce a catalyst vapor comprising catalyst droplets suspended in a gas phase; and contacting the catalyst vapor with a hydrocarbon gas to catalyze a decomposition reaction of the hydrocarbon gas into hydrogen gas and carbon. And, systems comprising: a catalyst source evaporator that provides a first stream to a reactor; a hydrocarbon source that provides a second stream to the reactor; a cooling column coupled to the reactor via a third stream comprising hydrogen, catalyst liquid, solid carbon, optionally catalyst gas, and optionally unreacted hydrocarbon gas such that the cooling column receives the third stream from the reactor; and wherein the cooling column has effluent streams that include (a) a fourth stream that comprises hydrogen and optionally catalyst gas and (b) a fifth stream that comprises catalyst liquid.
FILED Wednesday, September 16, 2020
APPL NO 17/022435
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 23/04 (20130101)
B01J 23/06 (20130101)
B01J 37/08 (20130101) Original (OR) Class
B01J 38/02 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 3/26 (20130101)
C01B 32/05 (20170801)
C01B 2203/06 (20130101)
C01B 2203/1076 (20130101)
C01B 2203/1241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170670 Barr et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Science Foundation (NSF)
APPLICANT(S) HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
ASSIGNEE(S) HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
INVENTOR(S) Christian G. Barr (Kansas City, Missouri);  George W. Bohnert (Harrisonville, Missouri)
ABSTRACT Methods and assemblies for additive manufacturing portions of components with enhanced strength are provided. The assemblies comprise a first deposition head and an apparatus for causing one or more reinforcement fibers to extend more than two layers within previously-deposited layers of build material. The first deposition head is configured to deposit a plurality of layers of a filament comprising a reinforcement fiber and thermoplastic material. The apparatus may comprise a needle point configured to be inserted into the plurality of layers to displace the reinforcement fiber so that it extends two or more of the plurality of layers. The apparatus may additionally or alternatively comprise a second deposition head having a needle tip configured to be inserted into the plurality of layers to inject a length of a second filament comprising thermoplastic material and a reinforcement fiber so that the reinforcement fiber of the second filament extends two or more layers of the plurality of layers of the first filament.
FILED Friday, December 06, 2019
APPL NO 16/705363
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801) Original (OR) Class
B29C 64/188 (20170801)
B29C 64/209 (20170801)
B29C 64/227 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210170679 Compel et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livemore, California)
ASSIGNEE(S)
INVENTOR(S) William Compel (Oakland, California);  Christopher Spadaccini (Oakland, California);  Marcus A. Worsley (Hayward, California)
ABSTRACT In accordance with one embodiment, a metal part includes a geometric three-dimensional printed structure consisting essentially of pure metal. In accordance with another embodiment, a metallic precursor resin includes a metallopolymer material including a metal-thiolate polymer. The metallopolymer material is a metallogel. The metallogel is substantially transparent and has a viscosity for enabling three-dimensional printing thereof.
FILED Thursday, December 05, 2019
APPL NO 16/705040
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 3/1055 (20130101)

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/153 (20170801) Original (OR) Class

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 70/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171345 MARKER et al.
FUNDED BY
Department of Energy (DOE)
National Science Foundation (NSF)
APPLICANT(S) Gas Technology Institute (Des Plaines, Illinois)
ASSIGNEE(S)
INVENTOR(S) Terry MARKER (Park Ridge, Illinois);  Martin B. LINCK (Wilmette, Illinois);  Jim WANGEROW (Oak Park, Illinois);  Pedro ORTIZ-TORAL (Wheeling, Illinois)
ABSTRACT Processes for converting methane and/or other hydrocarbons to synthesis gas (i.e., a gaseous mixture comprising H2 and CO) are disclosed, in which at least a portion of the hydrocarbon(s) is reacted with CO2. At least a second portion of the methane may be reacted with H2O (steam), thereby improving overall thermodynamics of the process, in terms of reducing endothermicity (AH) and the required energy input, compared to “pure” dry reforming in which no H2O is present. Catalysts for such processes advantageously possess high activity and thereby can achieve significant levels of methane conversion at temperatures below those used conventionally under comparable conditions. These catalysts also exhibit high sulfur tolerance, in addition to reduced rates of carbon (coke) formation, even in the processing (reforming) of heavier (e.g., naphtha boiling-range or jet fuel boiling-range) hydrocarbons. The robustness of the catalyst translates to high operating stability. A representative catalyst comprises 1 wt-% Pt and 1 wt-% Rh as noble metals, on a cerium oxide support.
FILED Wednesday, January 20, 2021
APPL NO 17/153375
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 23/10 (20130101)
B01J 23/63 (20130101)
B01J 23/6567 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 3/40 (20130101) Original (OR) Class
C01B 2203/043 (20130101)
C01B 2203/107 (20130101)
C01B 2203/0233 (20130101)
C01B 2203/0238 (20130101)
C01B 2203/0283 (20130101)
C01B 2203/0405 (20130101)
C01B 2203/1064 (20130101)
C01B 2203/1082 (20130101)
C01B 2203/1241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171369 Lister et al.
FUNDED BY
Department of Energy (DOE)
Battelle Energy Alliance, LLC (BEA)
APPLICANT(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho);  Boise State University (Idaho Falls, Idaho)
ASSIGNEE(S)
INVENTOR(S) Tedd E. Lister (Bangor, Maine);  Luis A. Diaz Aldana (Idaho Falls, Idaho);  Naqsh E. Mansoor (Boise, Idaho);  David Estrada (Boise, Idaho)
ABSTRACT A method of removing contaminants from a solution comprises passing a solution including one or more contaminants through a first cell comprising a first anode chamber and a first cathode chamber, passing a slurry comprising a flowing electrode material through the first anode chamber and the first cathode chamber while applying an electric potential between the first anode chamber and the first cathode chamber to transport anions from the solution to the first anode chamber and to transport cations from the solution to the first cathode chamber, the flowing electrode material comprising a MXene material, wherein M is a metal and X is one or both of carbon and nitrogen, and passing the slurry through a second cell to desorb the anions and cations from the flowing electrode material. Related systems for removing contaminants from a solution, and related methods are disclosed.
FILED Thursday, December 03, 2020
APPL NO 17/110487
CURRENT CPC
Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/4604 (20130101)
C02F 1/4691 (20130101) Original (OR) Class
C02F 1/46114 (20130101)
C02F 2101/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171393 CHEN et al.
FUNDED BY
Department of Energy (DOE)
National Science Foundation (NSF)
APPLICANT(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania);  DEPT. OF ENERGY (Pittsburgh, Pennsylvania)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTBURGH, Pennsylvania);  DEPT. OF ENERGY (PITTSBURGH, Pennsylvania)
INVENTOR(S) PENG CHEN (PITTSBURGH, Pennsylvania);  JACOB LORENZI POOLE (Pittsburgh, Pennsylvania);  PAUL R. OHODNICKI (ALLISON PARK, Pennsylvania);  MICHAEL PAUL BURIC (PITTSBURGH, Pennsylvania)
ABSTRACT An optical sensor device includes a multilayer hollow waveguide device having a hollow waveguide tube layer, an intermediate layer provided inside the hollow waveguide tube layer, and a metal oxide coating layer inside the intermediate layer.
FILED Wednesday, January 13, 2021
APPL NO 17/148298
CURRENT CPC
Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials
C03C 25/106 (20130101) Original (OR) Class
C03C 25/1061 (20180101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/05 (20130101)
G01N 21/553 (20130101)
G01N 21/774 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171419 Dagle et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
Pacific Northwest National Laboratory (PNNL)
APPLICANT(S) BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S) BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
INVENTOR(S) Vanessa M. Dagle (Richland, Washington);  Robert A. Dagle (Richland, Washington)
ABSTRACT Simple and economical conversion of aqueous ethanol feed streams into butenes by a single step method using transition metal oxides on a silica supports under preselected processing conditions. By directly producing a C4-rich olefin mixture from an ethanol containing stream various advantages are presented including, but not limited to, significant cost reduction in capital expenses and operational expenses.
FILED Monday, May 11, 2020
APPL NO 16/871285
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 1/20 (20130101) Original (OR) Class
C07C 11/08 (20130101)
C07C 2521/06 (20130101)
C07C 2523/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171557 Huang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
APPLICANT(S) NUtech Ventures (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Jinsong Huang (Lincoln, Nebraska);  Yang Bai (Westlake, Australia)
ABSTRACT Systems and methods for enhancing the stability and efficiency of perovskite materials, and devices incorporating such perovskite materials. A method of making a perovskite layer includes mixing a perovskite solution with a silica shell precursor solution to produce a perovskite-silica precursor solution, and spin casting or drop casting the perovskite-silica precursor solution on a substrate to form a perovskite material or material layer, wherein the perovskite material or material layer includes a plurality of groups of one or more perovskite grains, each of said plurality of groups wrapped in a silica shell. The silica shell precursor solution may have a chemical structure of Rn—Si—(OR)4-n, where “R” is an alkyl, aryl, or organofunctional group, and “OR” is a methoxy, ethoxy, or acetoxy group.
FILED Tuesday, December 10, 2019
APPL NO 16/709339
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 13/005 (20130101) Original (OR) Class

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/442 (20130101)
H01L 51/448 (20130101)
H01L 51/4213 (20130101)
H01L 51/4266 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171586 Bielicki et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Berkeley National Laboratory (LBNL)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) John K. Bielicki (San Ramon, California);  Jan Johansson (San Ramon, California);  Waleed Danho (Del Mar, California)
ABSTRACT The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer's Disease or frontotemporal dementia.
FILED Thursday, September 10, 2020
APPL NO 17/016541
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/17 (20130101)
A61K 45/06 (20130101)
A61K 47/64 (20170801)
A61K 47/544 (20170801)

Peptides
C07K 14/435 (20130101) Original (OR) Class
C07K 14/775 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171727 BAE
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
National Science Foundation (NSF)
APPLICANT(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
ASSIGNEE(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
INVENTOR(S) Chulsung BAE (Cohoes, New York)
ABSTRACT The electrochemical energy conversion system include an anode, a cathode, and a proton exchange membrane disposed between the anode and the cathode. The proton exchange membrane includes a polymer having a hard block polymer, a soft block polymer, and one or more hydrophilic functional groups attached to the soft block polymer. The glass transition temperature of the hard block polymer is higher than a glass transition temperature of the soft block polymer, such that the hard block polymer is non-elastic and the soft block polymer is elastic at a desired operating temperature. The hydrophilic functional groups are attached to the soft block polymer via a thiol-ene reaction to modify double bonds in the soft block polymer. The swellable functional groups are selectively connected to the soft domains of the block copolymers, so that when the membrane swells (under hydration or gas adsorption), the stress is effectively absorbed by the soft domain and the impact on overall mechanical properties is minor, resulting in more durable membranes.
FILED Thursday, December 06, 2018
APPL NO 16/770666
CURRENT CPC
Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 8/04 (20130101)
C08F 8/06 (20130101)
C08F 8/36 (20130101)
C08F 36/06 (20130101)
C08F 36/08 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/2231 (20130101) Original (OR) Class

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/37 (20130101)

Compositions of Macromolecular Compounds
C08L 25/08 (20130101)
C08L 53/025 (20130101)
C08L 65/02 (20130101)
C08L 71/12 (20130101)
C08L 81/06 (20130101)
C08L 2312/00 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 8/1023 (20130101)
H01M 8/1072 (20130101)
H01M 8/1088 (20130101)
H01M 2008/1095 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171846 Hu et al.
FUNDED BY
Department of Energy (DOE)
National Energy Technology Laboratory (NETL)
APPLICANT(S) West Virginia University (Morgantown, West Virginia)
ASSIGNEE(S)
INVENTOR(S) Jianli Hu (Morgantown, West Virginia);  Amoolya D. Lalsare (Morgantown, West Virginia);  Ali C. Sivri (Morgantown, West Virginia);  Cosmin E. Dumitrescu (Morgantown, West Virginia)
ABSTRACT In one aspect, the disclosure relates to methods for biomass gasification to produce sustainable and renewable alternatives to fossil fuels including, but not limited to syngas having a high H2 content. The method can produce an H2/CO ratio close to 2:1, which is desirable for further chemical or transportation fuel synthesis. In another aspect, the methods disclosed herein have high yields and make use of agricultural and industrial waste (e.g., hardwood pellets and grain stovers) as starting materials. In a further aspect, the methods disclosed herein can produce useful byproducts including, but not limited to, carbon nanofibers (CNF). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
FILED Monday, December 07, 2020
APPL NO 17/114427
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 21/18 (20130101)
B01J 23/881 (20130101)

Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases
C10J 3/02 (20130101) Original (OR) Class
C10J 3/82 (20130101)
C10J 2300/092 (20130101)
C10J 2300/0946 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172087 Hone et al.
FUNDED BY
Department of Energy (DOE)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
INVENTOR(S) James Hone (New York, New York);  Fang Liu (New York, New York);  Xiaoyang Zhu (New York, New York);  Sang Hoon Chae (New York, New York)
ABSTRACT Systems and methods for generating one or more single crystal monolayers from two-dimensional van der Waals crystals are disclosed herein. Example methods include providing a bulk material including a plurality of van der Waals crystal layers, and exfoliating one or more single crystal monolayers of van der Waals crystal from the bulk material by applying a flexible and flat metal tape to a surface of the bulk material. In certain embodiments, the one or more single crystal monolayers can be assembled into an artificial lattice. The present disclosure also provides techniques for manufacturing flexible and flat metal tape for generating one or more single crystal monolayers from two-dimensional van der Waals crystals. The present disclosure also provides compositions for creating a macroscopic artificial lattice. In certain embodiments, the composition can include two or more macroscopic single crystal monolayers adapted from a bulk van der Waals crystal, where the single crystal monolayers are configured for assembly into an artificial lattice based on one or more properties.
FILED Wednesday, November 25, 2020
APPL NO 17/105105
CURRENT CPC
Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 7/02 (20130101)
B32B 18/00 (20130101)
B32B 37/18 (20130101)
B32B 37/025 (20130101)
B32B 43/006 (20130101)
B32B 2315/02 (20130101)

Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/16 (20130101)
C23C 14/30 (20130101)

Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 29/46 (20130101)
C30B 29/68 (20130101)
C30B 33/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172799 Rimshaw et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Adam Rimshaw (Fairfield, Pennsylvania);  Christopher Grieco (Yonkers, New York);  Eric Kennehan (Berlin Center, Ohio);  John B. Asbury (State College, Pennsylvania)
ABSTRACT A high-sensitivity nanosecond to millisecond transient absorption spectrometer for measurements of miniscule signals under low excitation intensities includes an excitation source generating a frequency greater than 100 Hz, pulsewidth less than 5 ns excitation pulse for exciting a light absorbing sample, a probe light source for generating a photon flux probe light beam producing an average irradiance greater than 1 μW m−2 nm−1 for measuring the transient absorption spectrum of the sample before and after excitation by the excitation source, a DC-coupled detector capable of measuring light for enabling synchronous measurement of both the transmission of the probe light beam and the change in transmission of the probe light beam between a signal with the excitation pulse present and a signal in the absence of the excitation pulse, and a digital oscilloscope with a trigger rearm time capable of collecting every trigger event at high frequencies including 1 MHz, for enabling sequential noise subtraction protocols.
FILED Thursday, May 24, 2018
APPL NO 16/613717
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 3/18 (20130101)
G01J 3/42 (20130101) Original (OR) Class
G01J 3/0297 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/31 (20130101)
G01N 2021/3125 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 13/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172853 Launiere et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Cari A. Launiere (Bolingbrook, Illinois);  Peter A. Kozak (Willowbrook, Illinois);  Janine Lichtenberger (Burr Ridge, Illinois);  Candido Pereira (Naperville, Illinois)
ABSTRACT A sample generator system includes a fluid source and a flow cell. The sample generator system includes a sampling system in communication with the flow cell to eject a fluid sample through an orifice in the flow cell. The sample generator system includes a gas pressure at the orifice in the flow cell greater than or equal to a fluid pressure at the orifice in the flow cell.
FILED Tuesday, December 10, 2019
APPL NO 16/709520
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/10 (20130101)
G01N 15/1404 (20130101) Original (OR) Class
G01N 2001/1006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172855 Garrett et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S) University of Utah Research Foundation (, None)
INVENTOR(S) Tim Garrett (Salt Lake City, Utah);  Dhiraj Kumar Singh (Salt Lake City, Utah);  Karlie Rees (Salt Lake City, Utah);  Eric Pardyjak (Salt Lake City, Utah)
ABSTRACT A differential emissivity imaging device for measuring evaporable particle properties can include a heated plate, a thermal camera, a memory device, and an output interface. The heated plate can have an upper surface oriented to receive falling evaporable particles. The evaporable particles have a particle emissivity and the upper surface has a plate surface emissivity. The thermal camera can be oriented to produce a thermal image of the upper surface. A memory device can include instructions that cause the imaging device to calculate a mass of the individual evaporable particle via heat conduction using a calculated surface area and an evaporation time.
FILED Friday, November 27, 2020
APPL NO 17/106031
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 9/02 (20130101)
G01N 15/1429 (20130101) Original (OR) Class
G01N 2015/1087 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173160 PATRA et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Susant PATRA (Brentwood, California);  Razi-Ul Muhammad HAQUE (San Francisco, California);  Komal KAMPASI (San Francisco, California);  Ian Seth LADNER (Picayune, Mississippi)
ABSTRACT The present disclosure relates to a hybrid opto-electrical module apparatus. The apparatus may have a module substrate having a plurality of electrically conductive circuit traces for carrying electrical signals, and at least one waveguide element for carrying optical signals. A waveguide substrate is in optical communication with the waveguide element. A transducer is supported on the waveguide substrate and in electrical communication with the circuit traces. The waveguide substrate has at least one three dimensional (3D) waveguide formed within its interior volume for routing optical signals between the waveguide element and the transducer. A first optical wirebond interfaces the waveguide element to the 3D waveguide, and a second optical wirebond interfaces the 3D waveguide to the transducer.
FILED Monday, December 09, 2019
APPL NO 16/707764
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/421 (20130101)
G02B 6/4278 (20130101)
G02B 6/4291 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173650 Gutierrez et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
Lawrence Livermore National Laboratory (LLNL)
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S) Advanced Micro Devices, Inc. (Santa Clara, California)
INVENTOR(S) Anthony T. Gutierrez (Bellevue, Washington);  Bradford M. Beckmann (Bellevue, Washington);  Marcus Nathaniel Chow (Austin, Texas)
ABSTRACT A technique for determining whether a register value should be written to an operand cache or whether the register value should remain in and not be evicted from the operand cache is provided. The technique includes executing an instruction that accesses an operand that comprises the register value, performing one or both of a lookahead technique and a prediction technique to determine whether the register value should be written to an operand cache or whether the register value should remain in and not be evicted from the operand cache, and based on the determining, updating the operand cache.
FILED Wednesday, December 04, 2019
APPL NO 16/703833
CURRENT CPC
Electric Digital Data Processing
G06F 9/3838 (20130101)
G06F 9/3844 (20130101)
G06F 9/30047 (20130101)
G06F 9/30098 (20130101)
G06F 9/30145 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173940 Mylrea et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
Pacific Northwest National Laboratory (PNNL)
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Michael E. Mylrea (Alexandria, Virginia);  Sri Nikhil Gupta Gourisetti (Richland, Washington)
ABSTRACT Method include receiving banner information from one or more queries of a network connecting a set of devices, wherein the banner information of one or more of the devices includes common vulnerability and exposure identifiers (CVEs) and the banner information of one or more of the devices does not include a CVE, identifying the devices based on the banner information including classifying devices without known CVEs by a device type, determining vulnerability scores for the devices with known CVEs based on retrieved CVE information, and determining vulnerability scores for the devices without CVEs based on a series of exploitability and impact parameter estimates associated with the device type classifications. Some methods include estimating a cyberattack vulnerability risk for the devices using the determined vulnerability scores.
FILED Thursday, December 10, 2020
APPL NO 17/117752
CURRENT CPC
Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 19/058 (20130101)

Electric Digital Data Processing
G06F 16/285 (20190101)
G06F 16/953 (20190101)
G06F 21/577 (20130101) Original (OR) Class
G06F 2221/034 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210173971 Choi et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Youngsoo Choi (Livermore, California);  Sean Laughlin Mcbane (Austin, Texas)
ABSTRACT Systems and methods for optimizing a lattice structure design are disclosed herein. In some embodiments, a method for optimizing a lattice structure design can include (i) modeling the lattice structure with a component-wise reduced-order model (CWROM) and (ii) optimizing the CWROM based on a selected criterion using a topology optimization algorithm for lattice design. The selected criterion can include a boundary condition and a load applied to the lattice structure. By modeling the lattice structure as a CWROM, the optimization process can be very fast while still permitting the accurate computation of physical quantities of the lattice structure.
FILED Tuesday, December 10, 2019
APPL NO 16/709825
CURRENT CPC
Electric Digital Data Processing
G06F 30/20 (20200101) Original (OR) Class
G06F 30/23 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210174215 Chan et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Henry Chan (Schaumburg, Illinois);  Mathew J. Cherukara (Darien, Illinois);  Badri Narayanan (Louisville, Kentucky);  Subramanian Sankaranarayanan (Naperville, Illinois);  Stephen K. Gray (Wheaton, Illinois);  Troy David Loeffler (Chicago, Illinois)
ABSTRACT A method for optimizing objective functions can include selecting an objective function based at least on a hierarchy, applying parameters to the objective function to generate an output, responsive to the output not satisfying a tolerance condition, assigning a penalty to the set of parameters and evaluating a convergence condition using the set of parameters and the penalty, responsive to the output satisfying the tolerance condition, evaluating an additional objective function using the parameters in an order corresponding to the hierarchy or evaluating the convergence condition responsive to the selected objective function being a final objective function, modifying the set of parameters using a genetic algorithm responsive to the set of parameters not satisfying the convergence condition, and outputting the set of parameters responsive to the set of parameters satisfying the convergence condition.
FILED Thursday, December 05, 2019
APPL NO 16/704936
CURRENT CPC
Electric Digital Data Processing
G06F 16/282 (20190101)

Computer Systems Based on Specific Computational Models
G06N 3/126 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210174253 Moore et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Laboratory (LANL)
National Nuclear Security Administration (NNSA)
Triad National Security, LLC (Triad)
APPLICANT(S) Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S) Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S) Elisabeth Ann Moore (Los Alamos, New Mexico);  Nathan A. Debardeleben (Los Alamos, New Mexico);  Sean P. Blanchard (Los Alamos, New Mexico)
ABSTRACT Systems and methods for detecting anomalies in machine-generated logs are described. Machine-generated logs are processed and analyzed using machine learning models to determine whether a log message is anomalous. The system may use machine learning models that are configured to process particular types of log messages. An explanation for why the system detected an anomaly in the log message is also generated based on processing of the log message.
FILED Friday, October 02, 2020
APPL NO 17/061956
CURRENT CPC
Electric Digital Data Processing
G06F 11/0775 (20130101)
G06F 11/0781 (20130101)

Computer Systems Based on Specific Computational Models
G06N 5/003 (20130101)
G06N 20/00 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210174273 Olson et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
APPLICANT(S) Battelle Memorial Institute (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Jarrod R. Olson (Columbus, Ohio);  Tyler Coy (Columbus, Ohio);  Po-Hsu Chen (Columbus, Ohio);  Adrienne Cocci (Columbus, Ohio);  Amir Rahimi (Columbus, Ohio);  J. Elizabeth Jackson (Columbus, Ohio);  Amanda Morgan (Columbus, Ohio);  Jeffrey J. Geppert (Columbus, Ohio);  Nancy J. McMillan (Columbus, Ohio)
ABSTRACT Rapid prototyping of a process in a business domain, such as a healthcare domain or the United States healthcare domain, is disclosed. A computer is programmed to perform discrete event simulation (DES) of a scenario in the business domain. The DES is defined by a plurality of resources having resource attributes, a plurality of events having event attributes, and a plurality of entities having entity attributes. The computer is programmed to implement a DES simulator configured to run the scenario including performing time steps per resource in which the entities experience events.
FILED Thursday, November 19, 2020
APPL NO 16/952162
CURRENT CPC
Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/067 (20130101) Original (OR) Class
G06Q 50/22 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210174979 McCall et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California);  American Ceramic Technology (Poway, California)
ASSIGNEE(S)
INVENTOR(S) Scott McCall (Livermore, California);  Richard Culbertson (Poway, California)
ABSTRACT A magnetic shielding material includes a material comprising manganese bismuth (MnBi) and tungsten (W), where a ratio of MnBi:W is in a range of 50:50 to about 70:30. A radiation shielding product includes a part including manganese bismuth (MnBi) and tungsten (W), and a plurality of layers having a defined thickness in a z-direction, wherein each layer extends along an x-y plane perpendicular to the z-direction. At least some of the plurality of layers form a functional gradient in the z-direction and/or along the x-y plane, and the functional gradient is defined by a first layer comprising a ratio of MnBi:W being less than 100:0 and an nth layer above the first layer comprising a ratio of MnBi:W greater than 0:100.
FILED Friday, December 04, 2020
APPL NO 17/112726
CURRENT CPC
Alloys
C22C 30/00 (20130101)
C22C 2202/02 (20130101)

Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor
G21F 1/085 (20130101) Original (OR) Class

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 1/055 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175402 Choi et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Berkeley National Laboratory (LBNL)
APPLICANT(S) Jaeyoo Choi (, None);  Jeffrey J. Urban (Berkeley, California);  Tintoria Piana, US Inc. (Cartersville, Georgia)
ASSIGNEE(S)
INVENTOR(S) Jaeyoo Choi (Richmond, California);  Sang-hoon Lim (Kennesaw, Georgia);  Jeffrey J. Urban (Emeryville, California);  Andy Hollis (White, Georgia);  Andrea Piana (Atlanta, Georgia)
ABSTRACT A thermoelectric device suitable for power generation by the Seebeck effect or heating and cooling by the Peltier effect includes a flexible thermoelectric layer with a flexible heatsink layer. A thermally conductive layer can optionally be included on the side of the thermoelectric layer opposite the flexible heatsink layer. Because of its flexibility and durability, the thermoelectric device can be utilized for products such as a thermoelectric generator or cooling/heating system for consumer products, such as a bedding, clothing, hats, seat cushions, and personal portable devices.
FILED Tuesday, December 10, 2019
APPL NO 16/709412
CURRENT CPC
Outerwear; Protective Garments; Accessories
A41D 20/005 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 23/427 (20130101)
H01L 35/02 (20130101)
H01L 35/32 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175439 BEARD et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado);  University of Utah Research Foundation (Salt Lake City, Utah);  Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Matthew C. BEARD (Arvada, Colorado);  Haipeng LU (Lakewood, Colorado);  Annalise Elizabeth MAUGHAN (Arvada, Colorado);  Joseph Jonathan BERRY (Boulder, Colorado);  Zeev Valentine VARDENY (Salt Lake City, Utah);  Chuanxiao XIAO (Lakewood, Colorado);  Volker Wolfgang BLUM (Durham, North Carolina);  David Brian MITZI (Hillsborough, North Carolina)
ABSTRACT The present disclosure relates to a composition that includes a perovskite of A2BX4, where A includes an R-form of a chiral molecule of at least one of and/or an S-form of the chiral molecule, B includes a cation, X includes an anion, R1 includes a first carbon chain having between 2 and 5 carbon atoms, R2 includes at least one of a hydrogen atom, a halogen atom, a carboxylic acid group, an alkoxy group, and/or a second carbon chain, and R3 includes a third carbon chain.
FILED Wednesday, December 02, 2020
APPL NO 17/109668
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 7/24 (20130101)
C07F 7/2224 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/0077 (20130101) Original (OR) Class
H01L 51/102 (20130101)
H01L 51/0591 (20130101)
H01L 2251/308 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175517 Li et al.
FUNDED BY
Department of Energy (DOE)
Pacific Northwest National Laboratory (PNNL)
UT-Battelle, LLC (UT-BATTELLE)
APPLICANT(S) UT-BATTELLE, LLC (Oak Ridge, Tennessee);  Redox Power Systems, LLC (Beltsville, Maryland)
ASSIGNEE(S)
INVENTOR(S) Jianlin Li (Knoxville, Tennessee);  Dhrupadkumar P. Parikh (Knoxville, Tennessee);  Thomas Langdo (Great Falls, Virginia);  Sean R. Bishop (Albuquerque, New Mexico);  Bryan M. Blackburn (Bethesda, Maryland)
ABSTRACT A method of making a solid oxide fuel cell (SOFC) includes the steps of providing a first SOFC layer laminate tape comprising a first SOFC layer composition attached to a flexible carrier film layer, providing a second SOFC laminate tape comprising a second SOFC layer composition attached to a flexible carrier film layer, and providing a third SOFC layer laminate tape comprising a third SOFC layer composition attached to a flexible carrier film layer. The first SOFC layer laminate tape, the second SOFC layer laminate tape, and the third SOFC layer laminate tape are assembled on rolls positioned along a roll-to-roll assembly line. The laminate tapes are sequentially laminated and calendered and the flexible carrier films removed to provide a composite SOFC precursor laminate that can be sintered and combined with a cathode to provide a completed SOFC. An assembly for making composite SOFC precursor laminates is also disclosed.
FILED Thursday, December 10, 2020
APPL NO 17/118261
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/8605 (20130101)
H01M 8/004 (20130101) Original (OR) Class
H01M 8/1226 (20130101)
H01M 8/1246 (20130101)
H01M 2008/1293 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175553 VAN TASSELL et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Feasible, Inc. (Emeryville, California)
ASSIGNEE(S)
INVENTOR(S) Barry J. VAN TASSELL (El Cerrito, California);  Shan DOU (Berkeley, California);  Shaurjo BISWAS (El Cerrito, California);  Andrew G. HSIEH (Berkeley, California);  Andrew M. RAPHAEL (El Cerrito, California)
ABSTRACT Systems and methods for acoustic signal based analysis, include obtaining acoustic response signal data of at least a portion of a battery cell, the acoustic response signal data comprising waveforms generated by transmitting one or more acoustic excitation signals into at least the portion of the battery cell and recording response vibration signals to the one or more acoustic excitation signals. One or more metrics are determined from at least the acoustic response signal data, the one or more metrics being determined based on correlation of the one or more metrics to one or more characteristics of battery cells and a reference model is generated from the one or more metrics. A test battery can be evaluated using the reference model. Actionable insights or recommendations can be generated based on the evaluation. The reference model can also be updated based on the evaluation.
FILED Friday, December 04, 2020
APPL NO 17/112756
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 29/14 (20130101)
G01N 29/024 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/392 (20190101)

Transmission Systems for Measured Values, Control or Similar Signals
G08C 17/02 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/484 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175579 Carlson et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) OPTODOT CORPORATION (Devens, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Steven A. Carlson (Cambridge, Massachusetts);  lfenna Kingsley Anakor (Allston, Massachusetts);  Greg Robert Farrell (Sudbury, Massachusetts)
ABSTRACT Provided are separators for use in an electrochemical cell comprising (a) an inorganic oxide and (b) an organic polymer, wherein the inorganic oxide comprises organic substituents. Also provided are electrochemical cells comprising such separators.
FILED Monday, September 14, 2020
APPL NO 17/019584
CURRENT CPC
Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 14/303 (20130101)
C04B 24/00 (20130101)
C04B 24/023 (20130101)
C04B 26/06 (20130101)
C04B 38/0074 (20130101)
C04B 2111/00612 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 50/409 (20210101)
H01M 50/411 (20210101)
H01M 50/431 (20210101)
H01M 50/446 (20210101) Original (OR) Class

Technical Subjects Covered by Former US Classification
Y10T 29/49115 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175821 DATSKOS et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Panagiotis George DATSKOS (Golden, Colorado);  Jochem WEBER (Golden, Colorado);  Blake Craig BOREN (Corvallis, Oregon)
ABSTRACT Devices, methods, and systems for electrostatic machines which can act as both an electric motor, converting electrical energy to mechanical energy, and an electric generator, converting mechanical energy to electrical energy, are described. In some embodiments, a spring positioned between two oppositely charged plates may be used as an electric motor and/or electric generator.
FILED Friday, December 04, 2020
APPL NO 17/112338
CURRENT CPC
Electric Machines Not Otherwise Provided for
H02N 1/08 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175841 Betts et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency Energy (ARPAE)
APPLICANT(S) SUNFOLDING, INC. (San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Kyle Douglass Betts (San Francisco, California);  Joshua Earle Erickson (Oakland, California);  Dan Goldwater (Amherst, Massachusetts);  Jeffrey Charles Lamb (San Francisco, California);  Leila Madrone (San Francisco, California);  James Vincent Nolan, IV (San Francisco, California);  Vincent Domenic Romanin (San Francisco, California);  Matthew N. Schneider (Sierra Madre, California);  Eric Preston Lien Suan (Baltimore, Maryland)
ABSTRACT A solar tracker system having one or more solar trackers that each include one or more panels and one or more actuators coupled to the one or more panels, the one or more actuators having a first and second vessel; and an electronic control unit configured to inflate the first vessel with fluid from a fluid source and configured to separately inflate the second vessel with fluid from the fluid source. The electronic control unit is configured to determine that a stow event is present based on a first set of environmental data obtained from an environmental sensor that indicates environmental conditions pose a threat to the one or more solar trackers, and in response to determining that the stow event is present, actuate the one or more panels toward a stow configuration target angle by at least inflating the first or second vessels with fluid from the fluid source.
FILED Thursday, February 18, 2021
APPL NO 17/178593
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/142 (20130101)

Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for
F15B 15/10 (20130101)

Solar Heat Collectors; Solar Heat Systems
F24S 30/425 (20180501)
F24S 50/20 (20180501)
F24S 2030/12 (20180501)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/042 (20130101)

Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules
H02S 20/10 (20141201)
H02S 20/32 (20141201) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 20210170360 Lu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
National Aeronautics and Space Administration (NASA)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Jennifer Lu (Merced, California);  Wenxin Fu (Merced, California)
ABSTRACT A platform and system for concentration, reduction and regeneration of heavy metals and other contaminants from fluids is provided. The platform has a three-tiered hierarchical porous structure, composed of micropores formed by woven carbon cloth, nanopores formed after carbon nanotube growth on the cloth fibers and mesopores formed by a polymer outer layer. The material of the platform can be incorporated into cells with two electrodes with properly functionalized PDAN grafted 3D carbon as an anode and cathode respectively. Metal ions and toxic anions in water will be captured selectively by primary amine, secondary amine and quaternary amine groups in porous PDAN on the anode. Metals are captured and reduced by the cathode.
FILED Thursday, December 31, 2020
APPL NO 17/139813
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/205 (20130101) Original (OR) Class
B01J 20/262 (20130101)
B01J 20/265 (20130101)
B01J 20/3204 (20130101)
B01J 20/3219 (20130101)
B01J 20/3272 (20130101)
B01J 20/3295 (20130101)
B01J 20/28011 (20130101)
B01J 20/28033 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/4678 (20130101)
C02F 1/46109 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210171223 McDevitt et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
National Aeronautics and Space Administration (NASA)
APPLICANT(S) University of Vermont and State Agricultural College (Burlington, Vermont)
ASSIGNEE(S)
INVENTOR(S) Michael Ryan McDevitt (Burlington, Vermont);  Darren L. Hitt (Jericho, Vermont);  Patrick Lee (South Burlington, Vermont);  Sandra Romero Diez (Burlington, Vermont);  Alex Golden (Waban, Massachusetts);  Kevin Mongeon (Milton, Vermont);  Jon Watts (Wallingford, Vermont);  Lydia Hantsche (Burlington, Vermont);  Matthew Shea (Elverson, Pennsylvania)
ABSTRACT Propulsion systems that generate thrust from pressure generated by thermally decomposing a chemical blowing agent (CBA). In some embodiments, the CBA decomposes exothermically such that once thermal decomposition has been initiated, the thermal decomposition continues without additional energy input. In some embodiments, the CBA is utilized in a digital-microthruster array containing microthrusters that can be individually activated to provide thrust. In some embodiments, a CBA may be stored in one or more CBA-storage chambers that can be individually activated to charge and/or recharge a pressure tank that stores gas from the CBA decomposition under pressure for providing thrust. These and other embodiments are disclosed. Such propulsion systems can be used for any of a variety of spacecraft, including micro- and nano-satellites. Corresponding methods of generating thrust are also disclosed.
FILED Tuesday, June 12, 2018
APPL NO 16/622580
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/10 (20130101)
B64G 1/402 (20130101)
B64G 1/409 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172460 Keplinger et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Army Research Office (ARO)
National Aeronautics and Space Administration (NASA)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S) Christoph Matthias Keplinger (Gerlinger, Germany);  Xingrui Wang (Stuttgart, Germany);  Shane Karl Mitchell (Denver, Colorado)
ABSTRACT High strain hydraulically amplified self-healing electrostatic transducers having increased maximum theoretical and practical strains are disclosed. In particular, the actuators include electrode configurations having a zipping front created by the attraction of the electrodes that is configured orthogonally to a strain axis along which the actuators. This configuration produces increased strains. In turn, various form factors for the actuator configuration are presented including an artificial circular muscle and a strain amplifying pulley system. Other actuator configurations are contemplated that include independent and opposed electrode pairs to create cyclic activation, hybrid electrode configurations, and use of strain limiting layers for controlled deflection of the actuator.
FILED Thursday, December 10, 2020
APPL NO 17/117418
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/1075 (20130101)

Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for
F15B 5/006 (20130101) Original (OR) Class
F15B 15/103 (20130101)
F15B 21/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175044 Conversano et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Jet Propulsion Laboratory (JPL)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Ryan W. Conversano (Pasadena, California);  Dan M. Goebel (Pasadena, California);  Giulia Becatti (Pasadena, California)
ABSTRACT Systems and methods for providing a heaterless hollow cathode for use in electric propulsion devices is presented. According to one aspect the cathode includes a thermionic emitter having a constricted upstream inlet compared to a downstream outlet of the emitter. The emitter is arranged downstream a hollow cathode tube. Constriction of the upstream inlet is provided by an inner cylindrical hollow space at an upstream region of the emitter having a diameter that is smaller compared to a diameter of an inner cylindrical hollow space at a downstream region of the emitter. A hollow transition region having a varying diameter connects the upstream region to the downstream region. According to another aspect, a ratio of the diameters of the two cylindrical hollow spaces reduces penetration of electric field, and therefore of electric discharge, into the upstream region of the emitter during operation.
FILED Wednesday, November 25, 2020
APPL NO 17/104773
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/405 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 29/04 (20130101)
H01J 29/861 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175057 Cooks et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S) Robert Graham Cooks (West Lafayette, Indiana);  Dalton Snyder (West Lafayette, Indiana)
ABSTRACT The invention generally relates to systems and methods for performing multiple precursor, neutral loss and product ion scans in a single ion trap. In certain aspects, the invention provides systems including a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply at least one of the following ion scans to a single ion population in the single ion trap: multiple precursor ion scans, a plurality of segmented neutral loss scans, or multiple simultaneous neutral loss scans.
FILED Wednesday, January 27, 2021
APPL NO 17/159407
CURRENT CPC
Electric Discharge Tubes or Discharge Lamps
H01J 49/004 (20130101)
H01J 49/0013 (20130101)
H01J 49/0027 (20130101) Original (OR) Class
H01J 49/0081 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 20210169349 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  Louis Stokes Cleveland Veterans Administration Medical Center (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Nathaniel Braman (Bethel Park, Pennsylvania)
ABSTRACT Embodiments discussed herein facilitate determination of a response to treatment and/or a prognosis for a tumor based at least in part on features of tumor-associated vasculature (TAV). One example embodiment is a method, comprising: accessing a medical imaging scan of a tumor, wherein the tumor is segmented on the medical imaging scan; segmenting tumor-associated vasculature (TAV) associated with the tumor based on the medical imaging scan; extracting one or more features from the TAV; providing the one or more features extracted from the TAV to a trained machine learning model; and receiving, from the machine learning model, one of a predicted response to a treatment for the tumor or a prognosis for the tumor.
FILED Wednesday, December 09, 2020
APPL NO 17/116319
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/004 (20130101)
A61B 5/08 (20130101)
A61B 5/0035 (20130101)
A61B 5/02007 (20130101) Original (OR) Class
A61B 5/7267 (20130101)
A61B 5/7275 (20130101)
A61B 6/481 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 7/12 (20170101)
G06T 2207/10081 (20130101)
G06T 2207/10088 (20130101)
G06T 2207/20036 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/30061 (20130101)
G06T 2207/30068 (20130101)
G06T 2207/30096 (20130101)
G06T 2207/30101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172028 Tajbakhsh et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) Cedars-Sinai Medical Center (Los Angeles, California);  The Regents of the University of California (Oakland, California);  UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Jian Tajbakhsh (Encino, California);  Fariborz Mortazavi (Porter Ranch, California)
ABSTRACT In certain embodiments, this application discloses methods for detecting lung cancer. The method includes characterization of cells extracted from human sputum, which is a valuable tissue surrogate and source of upper respiratory cells that become cancerous early in the process of lung cancer development. The method includes the staining of extracted cells with fluorescent reporters that produce a specific pattern in the nuclei of labeled cells, which can be made visible by light microscopy. The pattern is relevant to a type of epigenetic coding of DNA known as DNA methylation, which changes in specific cells of the lung during cancer development, in comparison to normal respiratory cells.
FILED Friday, February 19, 2021
APPL NO 17/180433
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/154 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/30 (20130101)
G01N 33/57423 (20130101)
G01N 2440/12 (20130101)
G01N 2800/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172959 YANG et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California);  U.S. Government Represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S) Andrew YANG (Stanford, California);  Anton WYSS-CORAY (Stanford, California);  Kyle BREWER (Stanford, California)
ABSTRACT Provided herein are methods for labeling the proteomes of cells, as well as methods for labeling proteins or populations of proteins produced by cells. In some embodiments, the methods comprise introducing variant aminoacyl-tRNA synthetases and noncanonical amino acids into cells. Also provided herein are polynucleotides encoding variant aminoacyl-tRNA synthetases that recognize noncanonical amino acids. The methods and compositions provided herein are useful for, among other things, identifying target cells and identifying biomarkers of interest.
FILED Thursday, November 05, 2020
APPL NO 17/090261
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/93 (20130101)

Enzymes
C12Y 601/0102 (20130101)
C12Y 601/01001 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6842 (20130101) Original (OR) Class
G01N 2333/9015 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210174504 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  Louis Stokes Cleveland Veterans Administration Medical Center (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Nathaniel Braman (Bethel Park, Pennsylvania);  Tristan Maidment (Cleveland, Ohio);  Yijiang Chen (Cleveland, Ohio)
ABSTRACT Embodiments discussed herein facilitate determination of whether lesions are benign or malignant. One example embodiment is a method, comprising: accessing medical imaging scan(s) that are each associated with distinct angle(s) and each comprise a segmented region of interest (ROI) of that medical imaging scan comprising a lesion associated with a first region and a second region; providing the first region(s) of the medical imaging scan(s) to trained first deep learning (DL) model(s) of an ensemble and the second region(s) of the medical imaging scan(s) to trained second DL model(s) of the ensemble; and receiving, from the ensemble of DL models, an indication of whether the lesion is a benign architectural distortion (AD) or a malignant AD.
FILED Wednesday, December 09, 2020
APPL NO 17/116366
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 6/025 (20130101)
A61B 6/469 (20130101)
A61B 6/502 (20130101)
A61B 6/5217 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6256 (20130101)
G06K 2209/05 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/04 (20130101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/0012 (20130101) Original (OR) Class
G06T 2207/10112 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30068 (20130101)
G06T 2207/30096 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 30/40 (20180101)
G16H 50/20 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Commerce (DOC) 

US 20210172833 Ahmed
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)
INVENTOR(S) Zeeshan Ahmed (Washington, District of Columbia)
ABSTRACT A photonic resonator analyzer characterizes a photonic resonator and incudes a light source that provides a probe light; a photonic resonator that receives the probe light and produces product light; an optical detector that receives the product light and produces a product signal; a mode analyzer that receives the product signal and produces a resonator spectrum; and a spectral analyzer that receives the resonator spectrum, performs regression by fitting a non-parametric model to the resonator spectrum, and produces a thermal response function of the photonic resonator from fitting the non-parametric model to the resonator spectrum to characterize the photonic resonator.
FILED Monday, December 07, 2020
APPL NO 17/113222
CURRENT CPC
Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for
G01M 11/33 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175114 Holland
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)
INVENTOR(S) Glenn Emerson Holland (Rockville, Maryland)
ABSTRACT A non-vacuum, non-contact spinner wafer chuck including: a basal member including; a fastener receiver that receives a fastener; a chuck collar including: an inner collar wall; and an outer collar wall; and an engagement surface that: receives and engages a wafer; a wafer engagement cam including: an engagement face that engages the wafer; an index cam disposed on the chuck collar and comprising: an index face that faces toward the fastener receiver and that engages the wafer; and a spinner engager disposed on the spinner-side surface of the basal member and comprising: a spinner arm receiver bounded by a wall and that receives a spinner of the wafer processing machine, wherein the wafer engagement cam and the index cam engage the wafer and maintains an orientation of the wafer with respect to the index cam in response to rotation of the wafer relative to the non-vacuum, non-contact spinner wafer chuck.
FILED Friday, December 06, 2019
APPL NO 16/705798
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/68721 (20130101) Original (OR) Class
H01L 21/68735 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175419 SANGWAN et al.
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Office of Emerging Frontiers in Research and Innovation (EFRI)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Vinod K. SANGWAN (Evanston, Illinois);  Hong-Sub LEE (Evanston, Illinois);  Mark C. HERSAM (Wilmette, Illinois)
ABSTRACT One aspect of the invention relates to a multi-terminal memtransistor. The memtransistor includes a substrate having a first surface and an opposite, second surface, a polycrystalline monolayer film formed of an atomically thin material on the first surface of the substrate, an electrode array having a plurality of electrodes spatial-apart formed on the polycrystalline monolayer film such that each pair of electrodes defines a channel in the polycrystalline monolayer film therebetween, and a gate electrode formed on the second surface of the substrate and capacitively coupled with the channel. The polycrystalline monolayer film contains grains defining a plurality of grain boundaries thereof. The multi-terminal memtransistor operates much like a neuron by performing both memory and information processing, and can be a foundational circuit element for new forms of neuromorphic computing.
FILED Monday, December 17, 2018
APPL NO 16/770662
CURRENT CPC
Static Stores
G11C 13/0002 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/2436 (20130101)
H01L 45/145 (20130101)
H01L 45/1206 (20130101) Original (OR) Class
H01L 45/1253 (20130101)
H01L 45/1608 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

United States Postal Service (USPS) 

US 20210171201 Luckay et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Ryan M. Luckay (Vienna, Virginia);  Robert E. Dixon, JR. (Haymarket, Virginia);  Gregory Cooil (Arlington, Virginia)
ABSTRACT Methods and systems for attaching and detaching an item satchel from an autonomous delivery unit. An attachment system includes an attachment system frame, and a satchel comprising a plurality of external pins. The attachment system also includes a plurality of hooks, mechanically attached to the frame, each hook including a first engagement surface and a second engagement surface, one or more electric actuators, mechanically attached to the frame, and mechanically connected to the plurality of hooks. Each of the first engagement surfaces engage a corresponding pin of the plurality of external pins at a first position between the horizontal and vertical positions, and each of the second engagement surfaces engage the corresponding pin of the plurality of external pins at the vertical position to secure an item satchel to an autonomous delivery unit.
FILED Monday, January 25, 2021
APPL NO 17/157760
CURRENT CPC
Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for
B60R 11/00 (20130101)
B60R 2011/004 (20130101)
B60R 2011/0071 (20130101)

Motor Vehicles; Trailers
B62D 33/02 (20130101)

Aeroplanes; Helicopters
B64C 39/024 (20130101)
B64C 2201/128 (20130101)
B64C 2201/141 (20130101)

Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft
B64D 1/22 (20130101) Original (OR) Class

Systems for Controlling or Regulating Non-electric Variables
G05D 1/0011 (20130101)
G05D 1/0202 (20130101)
G05D 1/0276 (20130101)
G05D 1/0676 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210172747 Bonnell et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Clayton C. Bonnell (Fairfax, Virginia);  Neri G. Terry (Springfield, Virginia);  Kurt J. Schulz (Ballwin, Missouri)
ABSTRACT A method and system for generating a location identification grid and for using a location identification grid. The location identification grid can include a first geographic area that correspond to a pre-existing area. This pre-existing area can correspond to a postal code such as a zip code, a telephone code such as, an area code, or any other desired pre-existing area. The location identification grid can be subdivided into smaller geographic areas to allow more accurate identification of a location. The location identification grid can include a second geographic area. The second geographic area can be a subdivision of the first geographic area. The location identification grid can be used with signals that identify a location within a location identification grid. These signals can include a first component corresponding to the first geographic area and the second component corresponding to one or more second geographic areas.
FILED Friday, February 19, 2021
APPL NO 17/180584
CURRENT CPC
Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry
G01C 21/00 (20130101)
G01C 21/20 (20130101)
G01C 21/34 (20130101) Original (OR) Class
G01C 21/3667 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/10 (20130101)

Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams
G09B 29/007 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20210169419 OREN et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S)
INVENTOR(S) SEVAL OREN (Eskisehir, Turkey);  Liang Dong (Ames, Iowa)
ABSTRACT Methods, systems, and apparatus for high-resolution patterning of various substrates with functional materials, including nanomaterials. A technique of preparing a patterned substrate in a high-resolution mold for stick and transfer process is disclosed with promotes integrity of the high-resolution pattern onto the substrate. One example of a substrate is an adhesive tape. The transferred pattern(s) are scalable and can be implemented in different fabrication processes. One example is a roll-to-roll processes. In one embodiment, the transferred pattern comprises nanomaterials and the substrate comprises a flexible substrate for use in flexible and conformal assemblies for a wide variety of applications including, but not limited to, electrical-based sensors on non-planar inanimate surfaces, plant body surface, or human or animal skin.
FILED Monday, November 30, 2020
APPL NO 17/247112
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/01 (20130101)
A61B 5/002 (20130101)
A61B 5/1126 (20130101)
A61B 5/4266 (20130101)
A61B 5/6804 (20130101)
A61B 5/6806 (20130101)
A61B 5/6832 (20130101) Original (OR) Class
A61B 2503/40 (20130101)
A61B 2562/125 (20130101)
A61B 2562/0247 (20130101)
A61B 2562/0261 (20130101)
A61B 2562/0285 (20130101)

Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 7/12 (20130101)
B32B 9/041 (20130101)
B32B 9/045 (20130101)
B32B 37/12 (20130101)
B32B 37/025 (20130101)
B32B 2457/00 (20130101)

Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 1/205 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/0098 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Homeland Security (DHS) 

US 20210172889 Klueg
FUNDED BY
Department of Homeland Security (DHS)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S) Robert E. Klueg (Clayton, New Jersey)
ABSTRACT An X-ray imaging system for reconstructing X-ray spectra includes an integrating detector and a measurement mask, including at least one physical filter, positioned between the integrating detector and an X-ray source spectrum. The integrating detector receives a masked X-ray spectrum after the source spectrum has been filtered in accordance with the measurement mask. As a result of the measurement mask containing one or more physical filters being combined, a measurement mask having energy band-pass regions can be generated, to cover the source spectrum. Measured data, based on the masked X-ray spectrum and characteristics of the measurement mask, is collected from the integrating detector. The X-ray imaging system reconstructs an X-ray spectrum and generates the reconstructed X-ray spectrum based on applying a predetermined algorithm, such as total variation minimization reconstruction, to the measured data.
FILED Tuesday, January 26, 2021
APPL NO 17/158676
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 23/087 (20130101) Original (OR) Class

Measurement of Nuclear or X-radiation
G01T 1/362 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

MITRE Corporation (MITRE) 

US 20210174070 HENDERSON et al.
FUNDED BY
MITRE Corporation (MITRE)
APPLICANT(S) The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S) The MITRE Corporation (McLean, Virginia)
INVENTOR(S) John C. HENDERSON (Somerville, Massachusetts);  Lucy R. CHAI (Acton, Massachusetts);  Jeffrey ZARRELLA (Denver, Colorado);  Abigail S. GERTNER (Arlington, Massachusetts);  Keith J. MILLER (Washington, District of Columbia)
ABSTRACT Described are methods, systems, and computer-program product embodiments for selecting a face image based on a name. In some embodiments, a method includes receiving the name. Based on the name, a name vector is selected from a plurality of name vectors in a dataset that maps a plurality of names to a plurality of corresponding name vectors in a vector space, where each name vector includes representations associated with a plurality of words associated with each name. A plurality of face vectors corresponding to a plurality of face images is received. A face vector is selected from the plurality of face vectors based on a plurality of similarity scores calculated for the plurality of corresponding face vectors, where for each name vector, a similarity score is calculated based on the name vector and each face vector. The face image is output based on the selected face vector.
FILED Monday, February 22, 2021
APPL NO 17/181707
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/66 (20130101)
G06K 9/00288 (20130101) Original (OR) Class
G06K 9/6248 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Reconnaissance Office (NRO) 

US 20210175630 Boyarsky et al.
FUNDED BY
National Reconnaissance Office (NRO)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Michael Boyarsky (Durham, North Carolina);  Timothy Sleasman (Durham, North Carolina);  Jonah Gollub (Durham, North Carolina);  Seyedmohammadreza Faghih Imani (Tempe, Arizona);  David R. Smith (Durham, North Carolina)
ABSTRACT According to various embodiments, systems and methods for spatial sampling in proximity to the Nyquist limit in traveling-wave antenna systems are disclosed. An apparatus can include a traveling-wave antenna array comprising a plurality of adjacent traveling-wave antennas that each include a plurality of tunable elements that are spaced at, near, or above a Nyquist limit spacing to form an array of tunable elements. The apparatus also includes a phase diversity feed coupled to the traveling-wave antenna array that is configured to provide input to the traveling-wave antenna array including phase diverse input to two or more of the plurality of adjacent traveling-wave antennas. Further, the apparatus includes a plurality of grayscale tuning elements configured to tune the plurality of tunable elements along one or more ranges of one or more tuning variables to form one or more specific output radiation patterns through the traveling-wave antenna array based on the input.
FILED Wednesday, November 25, 2020
APPL NO 17/105020
CURRENT CPC
Antennas, i.e Radio Aerials
H01Q 1/38 (20130101)
H01Q 11/02 (20130101) Original (OR) Class
H01Q 13/20 (20130101)
H01Q 21/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 20210169336 Sanchez et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) ENSPECTRA HEALTH, INC. (Mountain View, California)
ASSIGNEE(S)
INVENTOR(S) Gabriel Sanchez (Menlo Park, California);  Fred Landavazo, IV (Redwood City, California);  Kathryn Montgomery (Mountain View, California);  Piyush Arora (San Carlos, California)
ABSTRACT The present disclosure provides methods and systems for identifying a tissue characteristic in a subject. Identifying a tissue characteristic may comprise accessing a database comprising a first set of data from a first image obtained from a first tissue region of the subject and a second set of data from a second image obtained from a second tissue region of the subject; computer processing the first set of data and the second set of data to (i) identify a presence or absence of one or more features indicative of the tissue characteristic in the first image, and (ii) classify the subject as being positive or negative for the tissue characteristic based on the presence or absence of the one or more features in the first image; and generating an electronic report which is indicative of the subject being positive or negative for the tissue characteristic.
FILED Thursday, November 12, 2020
APPL NO 17/096602
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0022 (20130101)
A61B 5/0066 (20130101)
A61B 5/0068 (20130101)
A61B 5/0071 (20130101)
A61B 5/0075 (20130101)
A61B 5/0077 (20130101) Original (OR) Class
A61B 5/444 (20130101)
A61B 5/445 (20130101)
A61B 5/7264 (20130101)
A61B 2562/028 (20130101)
A61B 2562/0242 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Government Rights Acknowledged 

US 20210172335 Vu et al.
FUNDED BY
APPLICANT(S) United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Ky H. Vu (East Hartford, Connecticut);  Brian R. Pelletier (Berwick, Maine)
ABSTRACT A gas turbine engine includes a primary flowpath connecting a compressor section, a combustor section and a turbine section. The turbine section includes a stage vane having a radially outward platform and a vane extending into the primary flowpath. The platform includes a cooling plenum. At least one retaining feature extends radially outward from the platform. At least one vectored cooling hole is disposed in the retaining feature and is configured to direct cooling air from the plenum to an adjacent gaspath component.
FILED Wednesday, December 04, 2019
APPL NO 16/702887
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 9/041 (20130101)
F01D 11/24 (20130101)
F01D 25/12 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210175010 Nichols et al.
FUNDED BY
APPLICANT(S) Honeywell International Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)
INVENTOR(S) C. Spencer Nichols (Marietta, Georgia);  Chad Langness (Golden Valley, Minnesota);  Adam Dally (Champlin, Minnesota);  James Goeders (Minneapolis, Minnesota)
ABSTRACT A shield for a cryogenic chamber and a cryogenic chamber comprising a shield are described. In an example embodiment, a cryogenic chamber comprises an interior housing comprising housing walls that define an action chamber. The action chamber is configured to be cryogenically cooled to an action temperature. The cryogenic chamber further comprises an interior shield at least partially sandwiched within the housing walls. The interior shield is made of a first material that acts as a superconductor at the action temperature.
FILED Thursday, December 05, 2019
APPL NO 16/704210
CURRENT CPC
Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 6/04 (20130101)
H01F 6/06 (20130101)
H01F 27/365 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

How To Use This Page 

THE FEDINVENT PATENT APPLICATION DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Thursday, June 10, 2021.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
     National Institutes of Health (NIH)
         National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
     Defense Advanced Research Projects Agency (DARPA)
         Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract is p