FedInvent Patent Applications

Patent Application Details for Thursday, June 17, 2021 

This page was updated on Saturday, July 17, 2021 at 01:39 AM GMT

Department of Health and Human Services (HHS) 

US 20210177032 LONGO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) UNIVERSITY OF SOUTHERN CALIFORNIA (LOS ANGELES, California)
ASSIGNEE(S)
INVENTOR(S) Valter D. LONGO (Play del Rey, California);  Chia-Wei CHENG (Los Angeles, California);  Sebastian BRANDHORST (Redondo Beach, California);  Min WEI (West Covina, California)
ABSTRACT A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. The first diet includes less than 30 g of sugar on the first day; less than 20 g of sugar on the second to fifth days; less than 28 g of proteins on the first day; less than 18 g of proteins on days the second to fifth days; 20 to 30 grams of monounsaturated fats on the first day; 10 to 15 grams of monounsaturated fats on the second to fifth days; and between 6 and 10 grams of polyunsaturated fats on the first day.
FILED Tuesday, February 23, 2021
APPL NO 17/182676
CURRENT CPC
Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 29/37 (20160801)
A23L 33/15 (20160801)
A23L 33/16 (20160801)
A23L 33/17 (20160801)
A23L 33/30 (20160801)
A23L 33/40 (20160801) Original (OR) Class
A23L 33/115 (20160801)
A23L 33/155 (20160801)
A23L 33/175 (20160801)

Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages
A23V 2002/00 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 45/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177627 Segil et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado);  Point Designs LLC (Lafayette, Colorado)
ASSIGNEE(S)
INVENTOR(S) Jacob Segil (Boulder, Colorado);  Stephen Huddle (Thornton, Colorado);  Levin Sliker (Boulder, Colorado);  Richard Weir (Lafayette, Colorado)
ABSTRACT Various embodiments of the present invention generally relate to prosthetic partial finger designs that can mimic the last two joints of the finger. Some embodiments include a proximal phalange, a distal phalange coupled to the proximal phalange, and a knuckle track (e.g., formed in an arc). The knuckle track can be moveably coupled to the proximal phalange an may include multiple teeth formed on which the proximal phalange slides along. A ratcheting mechanism can contact the multiple teeth to allow sliding in only a first direction while the ratcheting mechanism is engaged. Some embodiments include a release mechanism (e.g., a button) configured to disengage the ratcheting mechanism from the multiple teeth to allow the distal phalange to slide in a second direction. In some embodiments, the device may include a spring-back capability that automatically extends the finger after reaching full finger flexion, enabling one-handed use.
FILED Monday, February 01, 2021
APPL NO 17/164480
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/66 (20130101)
A61F 2/72 (20130101)
A61F 2/586 (20130101) Original (OR) Class
A61F 2/5046 (20130101)
A61F 2002/587 (20130101)
A61F 2002/5038 (20130101)
A61F 2002/5056 (20130101)
A61F 2002/5072 (20130101)
A61F 2002/6621 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 80/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177750 Bellinger et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Womens's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Womens's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S) Andrew Bellinger (Wellesley, Massachusetts);  Shiyi Zhang (Shanghai, China PRC);  Carlo Giovanni Traverso (Newton, Massachusetts);  Robert S. Langer (Newton, Massachusetts);  Stacey Mo (Darien, Illinois);  Tyler Grant (Arlington, Massachusetts);  Mousa Jafari (Waltham, Massachusetts);  Dean Liang Glettig (Cambridge, Massachusetts);  Angela DiCiccio (San Francisco, California);  Lowell L. Wood, JR. (Bellevue, Washington);  Philip A. Eckhoff (Kirkland, Washington)
ABSTRACT Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.
FILED Friday, February 12, 2021
APPL NO 17/174458
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/48 (20130101)
A61K 9/0053 (20130101)
A61K 9/0065 (20130101) Original (OR) Class
A61K 31/65 (20130101)
A61K 31/357 (20130101)
A61K 31/7048 (20130101)
A61K 47/10 (20130101)
A61K 47/32 (20130101)
A61K 47/34 (20130101)
A61K 47/40 (20130101)
A61K 47/42 (20130101)
A61K 47/58 (20170801)
A61K 47/6901 (20170801)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 31/002 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 18/73 (20130101)
C08G 18/4277 (20130101)
C08G 63/08 (20130101)
C08G 83/006 (20130101)
C08G 2230/00 (20130101)

Compositions of Macromolecular Compounds
C08L 33/02 (20130101)
C08L 33/08 (20130101)
C08L 33/14 (20130101)
C08L 2203/02 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177751 Ensign et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Laura Ensign (Towson, Maryland);  Justin Hanes (Baltimore, Maryland);  Abhijit Date (Baltimore, Maryland);  Yoo Chun Kim (Odenton, Maryland)
ABSTRACT Hypotonic gelling vehicles are used as solubilizing agents for drugs and as a means to provide sustained drug delivery to a mucosal tissue. Solubilizing drugs at higher concentrations enhances drug penetration into the tissues of the body, while the hypotonic gelling vehicle further improves distribution of the drug over a larger surface area for increased absorption and sustained release for reduced side effects and longer duration of action.
FILED Friday, December 07, 2018
APPL NO 16/770792
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101) Original (OR) Class
A61K 9/0048 (20130101)
A61K 31/404 (20130101)
A61K 31/473 (20130101)
A61K 31/498 (20130101)
A61K 31/542 (20130101)
A61K 38/13 (20130101)
A61K 47/34 (20130101)
A61K 47/38 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177769 HAYES et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
National Science Foundation (NSF)
APPLICANT(S) THE PENN STATE RESEARCH FOUNDATION (UNIVERSITY PARK, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Daniel J HAYES (State College, Pennsylvania);  Mohammad ABU-LABAN (State College, Pennsylvania)
ABSTRACT In one aspect, compositions are described herein. A composition described herein comprises a nanoparticle, a therapeutic species, and a linker joining the nanoparticle to the therapeutic species. The linker joining the nanoparticle to the therapeutic species comprises a Diels-Alder cyclo-addition reaction product. Additionally, in some embodiments, the nanoparticle is a magnetic nanoparticle.
FILED Friday, July 13, 2018
APPL NO 16/630806
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5094 (20130101) Original (OR) Class
A61K 9/5115 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177770 SAILOR et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Eye Institute (NEI)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) SPINNAKER BIOSCIENCES, INC. (Solana Beach, California);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S) SPINNAKER BIOSCIENCES, INC. (Solana Beach, California);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S) Michael J. SAILOR (La Jolla, California);  Jinyoung KANG (La Jolla, California);  Jinmyoung JOO (Seoul, South Korea);  Emily ANGLIN (San Marcos, California);  Ester KWON (Cambridge, Massachusetts);  Matthew SKALAK (Boston, Massachusetts);  Sangeeta BHATIA (Lexington, Massachusetts)
ABSTRACT Compositions useful in the controlled delivery of therapeutic agents and their methods of preparation and use are provided. The compositions comprise an optionally oxidized porous silicon core, a layer on the surface of the porous silicon core that comprises a metal silicate, and a therapeutic agent. The compositions optionally further comprise one or more targeting agents and/or cell-penetrating agents to enable the particles to target and enter cells or tissues of interest in a treated subject.
FILED Friday, April 14, 2017
APPL NO 16/093131
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5115 (20130101) Original (OR) Class
A61K 9/5192 (20130101)
A61K 38/17 (20130101)
A61K 38/162 (20130101)
A61K 49/0004 (20130101)
A61K 49/0013 (20130101)
A61K 49/0093 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)
C12N 2310/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177776 SPIEGEL et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Enzo Therapeutics, Inc. (Farmingdale, New York);  Virginia Commonwealth University (Richmond, Virginia)
ASSIGNEE(S) Enzo Therapeutics, Inc. (Farmingdale, New York);  Virginia Commonwealth University (Richmond, Virginia)
INVENTOR(S) Sarah SPIEGEL (Richmond, Virginia);  Robert Elliot ZIPKIN (Wynnewood, Pennsylvania);  Jeffrey Kroll ADAMS (Fort Washington, Pennsylvania)
ABSTRACT Provided are inhibitors of sphingosine kinase Type I that are useful in the treatment of neuropathic pain.
FILED Monday, February 08, 2021
APPL NO 17/169662
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/40 (20130101)
A61K 31/135 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 11/06 (20180101)

Acyclic or Carbocyclic Compounds
C07C 215/28 (20130101)
C07C 217/64 (20130101)
C07C 233/18 (20130101)
C07C 323/32 (20130101)

Heterocyclic Compounds
C07D 263/06 (20130101)
C07D 295/092 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177819 Surmeier et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) D. James Surmeier (Chicago, Illinois);  Michelle Day (Chicago, Illinois);  Jun Ding (Chicago, Illinois);  C. Savio Chan (Chicago, Illinois);  Jaime Guzman (Wilmette, Illinois);  Jeff Mercer (Chicago, Illinois);  Tatiana Tkatch (Chicago, Illinois);  Zhongfeng Wang (Evanston, Illinois);  Ema Ilijic (Chicago, Illinois)
ABSTRACT The present invention relates to methods and compositions for modulating calcium channels. In particular, the present invention provides methods and compositions for modulating (e.g., disrupting) Cav1.3a calcium channels for research and therapeutic methods (e.g., treating dopaminergic diseases and conditions).
FILED Thursday, October 08, 2020
APPL NO 17/065645
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4439 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177831 Demehri
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Office of the Director (NIHOD)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Shadmehr Demehri (Charlestown, Massachusetts)
ABSTRACT Described herein are compositions comprising a T cell/thymic stromal lymphopoietin (TSLP) activating agent and an innate immunity activating agent, an methods of use thereof to treat cancer, e.g., cutaneous malignancies.
FILED Tuesday, July 02, 2019
APPL NO 17/257426
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0014 (20130101)
A61K 31/55 (20130101)
A61K 31/203 (20130101)
A61K 31/353 (20130101)
A61K 31/593 (20130101)
A61K 31/711 (20130101)
A61K 31/4745 (20130101) Original (OR) Class
A61K 31/7084 (20130101)
A61K 35/763 (20130101)
A61K 38/193 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177832 CHOUDHARY et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Department of the Navy (DON)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Amit CHOUDHARY (Boston, Massachusetts);  Basudeb MAJI (Cambridge, Massachusetts);  Soumyashree Ashok GANGOPADHYAY (Boston, Massachusetts);  Miseon LEE (Cambridge, Massachusetts);  Mengchao SHI (Boston, Massachusetts)
ABSTRACT Compositions and methods for inhibiting the activity of RNA-guided endonucleases, and methods for identifying such compositions are included. Methods of treatment using the inhibitory compounds, formulations and methods are also detailed, as well as control of nucleic acid editing systems and methods using said compounds.
FILED Tuesday, August 20, 2019
APPL NO 17/269900
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4745 (20130101) Original (OR) Class
A61K 31/7105 (20130101)
A61K 38/465 (20130101)
A61K 47/54 (20170801)
A61K 47/545 (20170801)

Heterocyclic Compounds
C07D 471/04 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/99 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177836 SEBTI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida);  UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
ASSIGNEE(S)
INVENTOR(S) SAID M. SEBTI (TAMPA, Florida);  NICHOLAS J. LAWRENCE (TAMPA, Florida);  JAMES TURKSON (HONOLULU, Hawaii)
ABSTRACT The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention.
FILED Thursday, October 22, 2020
APPL NO 17/077100
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/495 (20130101) Original (OR) Class
A61K 33/24 (20130101)

Heterocyclic Compounds
C07D 295/088 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5091 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177854 Blazar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Pharmacyclics LLC (Sunnyvale, California);  Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Bruce R. Blazar (Golden Valley, Minnesota);  Ryan Flynn (Minneapolis, Minnesota)
ABSTRACT Described herein are methods for treating and preventing alloantibody driven chronic graft versus host disease (cGVHD). The methods include administering to an individual in need thereof ibrutinib for treating and preventing alloantibody driven graft versus host disease.
FILED Wednesday, July 29, 2020
APPL NO 16/942151
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/519 (20130101) Original (OR) Class
A61K 35/28 (20130101)
A61K 45/06 (20130101)
A61K 2035/124 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177860 Mansour et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) Heidi M. Mansour (Tucson, Arizona);  Stephen Black (Tucson, Arizona);  Priyadarshini Muralidharan (Tucson, Arizona)
ABSTRACT Provided herein are compositions and methods for treating pulmonary hypertension. In particular, provided herein are dry powder formulations of fasudil for delivery to the lung.
FILED Thursday, October 25, 2018
APPL NO 16/759102
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0075 (20130101)
A61K 9/5089 (20130101)
A61K 9/5192 (20130101)
A61K 31/551 (20130101) Original (OR) Class
A61K 45/06 (20130101)
A61K 47/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177909 SAEKI et al.
FUNDED BY
Department of Health and Human Services (HHS)
Centers for Disease Control and Prevention (CDC)
Center for Global Health (CGH)
APPLICANT(S) NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE (Tokyo, Japan);  ID Pharma Co., Ltd. (Tokyo, Japan)
ASSIGNEE(S)
INVENTOR(S) Kumiko SAEKI (Tokyo, Japan);  Norihiko KOBAYASHI (Tokyo, Japan);  Masako OKA (Tokyo, Japan);  Kazunori MATSUMURA (Tokyo, Japan);  Miwako NISHIO (Tokyo, Japan);  Tsugumine SHU (Tokyo, Japan);  Toyotaka MORI (Tokyo, Japan)
ABSTRACT The present invention provides a composition having a metabolism-improving action, which comprises a supernatant of brown adipocytes or a purified product thereof. The present invention also provides a method of preparing the supernatant without using a culture solution comprising a high concentration of glucose. The present invention also provides a method of producing brown adipocytes using pluripotent stem cells, which are useful for preparing the supernatant of brown adipocytes. The present invention has succeeded in obtaining a supernatant having a metabolism-improving action from brown adipocytes. It was also possible to obtain the supernatant without using a culture solution comprising a high concentration of glucose. The present invention has also succeeded in producing brown adipocytes from pluripotent stem cells using a feeder-free culture system without adding a cytokine cocktail or the like. The brown adipocyte supernatant of the present invention is expected to be applied to the development of therapeutic agents and cosmetic products for glucose metabolism diseases.
FILED Wednesday, August 14, 2019
APPL NO 17/268190
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/35 (20130101) Original (OR) Class
A61K 35/545 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)
A61P 17/02 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0031 (20130101)
C12N 5/0653 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177917 Gallo et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Richard L. Gallo (San Diego, California);  Michael Williams (San Diego, California)
ABSTRACT The disclosure relates to composition and methods to treat dermatological diseases and disorders and to composition that modulate skin barrier permeability.
FILED Friday, August 31, 2018
APPL NO 16/642340
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 9/0014 (20130101)
A61K 35/741 (20130101) Original (OR) Class
A61K 38/08 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 17/00 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/37 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 2333/96425 (20130101)
G01N 2800/202 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177918 Gajewski et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Thomas F. Gajewski (Chicago, Illinois);  Jason Luke (Oak Park, Illinois);  Riyue Bao (Chicago, Illinois);  Vyara Matson (Chicago, Illinois);  Jessica Fessler (Chicago, Illinois)
ABSTRACT Provided herein are compositions and methods comprising microbiome biomarkers of responsiveness/resistance to immunotherapy (e.g., anti-PD1/PD-L1 therapy), and diagnostic, prognostic and therapeutic uses thereof. In particular, the amount, identity, presence, and/or ratio of microflora in the microbiome of a subject is used to determine the responsiveness/resistance of the subject to immunotherapy, and/or the microbiome of a subject is manipulated to enhance the responsiveness of the subject to various immunotherapies and co-therapies.
FILED Tuesday, June 05, 2018
APPL NO 16/618700
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/745 (20130101) Original (OR) Class
A61K 35/747 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/2818 (20130101)
C07K 16/2827 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177938 Langer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S) Robert S. Langer (Newton, Massachusetts);  Carlo Giovanni Traverso (Newton, Massachusetts);  Junwei Li (Cambridge, Massachusetts);  Thomas Wang (Cambridge, Massachusetts);  Ameya R. Kirtane (Somerville, Massachusetts);  Yunhua Shi (Arlington, Massachusetts)
ABSTRACT The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.
FILED Thursday, December 10, 2020
APPL NO 17/118521
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/495 (20130101)
A61K 38/1787 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0065 (20130101)

Enzymes
C12Y 111/01006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177943 GRINSPOON
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S) The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S) Steven K. GRINSPOON (Weston, Massachusetts)
ABSTRACT The present application relates to novel methods for preventing, slowing the progression of, or treating nonalcoholic fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), and/or liver fibrosis, and/or reducing the risks of liver cancer in subjects, such as HIV-infected subjects, using a GHRH molecule, e.g., trans-3-hexenoyl-GHRH(1-44)-NH2, or a pharmaceutically acceptable salt thereof. The subjects may have particular pathological features such as liver fibrosis, a hepatic fat fraction (HFF) of at least about 10%, serum alanine aminotransferase (ALT) levels of at least about 30 U/L, and/or a NAFLD Activity Score (NAS) of at least 4 or 5.
FILED Monday, February 08, 2021
APPL NO 17/170579
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 38/25 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177956 Sun
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Albany Medical College (Albany, New York)
ASSIGNEE(S) Albany Medical College (Albany, New York)
INVENTOR(S) Wei Sun (Glenmont, New York)
ABSTRACT A vaccine platform using a Yersinia pestis mutant synthesizing an adjuvant form lipid A (monophosphoryl lipid A, MPLA) for the increased biogenesis of bacterial outer membrane vesicles (OMVs). To enhance the immunogenicity of the OMVs, an Asd-based balanced-lethal host-vector system was constructed to oversynthesize the LcrV antigen of Y. pestis, raise the amounts of LcrV enclosed in OMVs by Type II secretion system, and eliminate harmful factors like plasminogen activator (Pla) and murine toxin from the OMVs. Vaccination with OMVs containing MPLA and increased amounts of LcrV with diminished toxicity afforded complete protection in mice against subcutaneous challenge and intranasal challenge and was significantly superior to that resulting from vaccination with LcrV/alhydrogel. Additionally, the Yersinia OMV can be used as a platform to deliver the heterologous antigens of Bacillus anthraces. Vaccination with multiantigenic self-adjuvanting bionanoparticles from Pseudomonas was also successfully tested in connection with Pseudomonas aeruginosa.
FILED Thursday, December 10, 2020
APPL NO 17/117417
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/104 (20130101)
A61K 39/0291 (20130101) Original (OR) Class
A61K 2039/55594 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177958 LIVENGOOD et al.
FUNDED BY
Department of Health and Human Services (HHS)
Assistant Secretary for Preparedness and Response (ASPR)
Biomedical Advanced Research and Development Authority (BARDA)
Centers for Disease Control and Prevention (CDC)
APPLICANT(S) TAKEDA VACCINES, INC. (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Jill A LIVENGOOD (Cambridge, Massachusetts);  Hansi DEAN (Cambridge, Massachusetts);  Htay Htay HAN (Cambridge, Massachusetts);  Raman RAO (Singapore, Singapore);  Jackie MARKS (Cambridge, Morocco);  Gary DUBIN (Glattpark-Opfikon, Zurich, Switzerland);  Laurence DE MOERLOOZE (Glattpark-Opfikon, Zurich, Switzerland);  Hetal PATEL (Cambridge, Massachusetts);  Sushma KOMMAREDDY (Cambridge, Massachusetts)
ABSTRACT The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.
FILED Monday, November 05, 2018
APPL NO 16/761329
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 39/12 (20130101) Original (OR) Class
A61K 39/39 (20130101)
A61K 2039/5252 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177959 LIVENGOOD et al.
FUNDED BY
Department of Health and Human Services (HHS)
Assistant Secretary for Preparedness and Response (ASPR)
Biomedical Advanced Research and Development Authority (BARDA)
Centers for Disease Control and Prevention (CDC)
APPLICANT(S) TAKEDA VACCINES, INC. (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Jill A. LIVENGOOD (Cambridge, Massachusetts);  Holli GIEBLER (Cambridge, Massachusetts);  Hansi DEAN (Cambridge, Massachusetts);  Tatsuki SATOU (Hikari-shi, Yamaguchi, Japan);  Raman RAO (Singapore, Singapore);  Jackie MARKS (Cambridge, Massachusetts);  Mark LYONS (Cambridge, Massachusetts);  Asae SHINTANI (Hikari-shi, Yamaguchi, Japan);  Jamie GIFFORD (Cambridge, Massachusetts)
ABSTRACT The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.
FILED Monday, November 05, 2018
APPL NO 16/761340
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101) Original (OR) Class
A61K 2039/5252 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177960 Collins et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland)
INVENTOR(S) Peter L. Collins (Silver Spring, Maryland);  Thomas Charles McCarty (Bethesda, Maryland)
ABSTRACT Reported herein are novel recombinant respiratory syncytial viruses (RSV) having an attenuated phenotype in which the native positions of the NS1 and/or NS2 genes in the RSV genome are shifted to a higher position, that is at positions that are more distal to the promoter. The changes in the gene positions may be present in combination with mutations at other loci to achieve desired levels of attenuation and immunogenicity. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses.
FILED Tuesday, February 23, 2021
APPL NO 17/183227
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101) Original (OR) Class
A61K 2039/5254 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 7/04 (20130101)
C12N 2760/18521 (20130101)
C12N 2760/18534 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177962 DIAMOND et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) CITY OF HOPE (Duarte, California)
ASSIGNEE(S) CITY OF HOPE (Duarte, California)
INVENTOR(S) Don J. DIAMOND (Glendora, California);  Felix WUSSOW (Duarte, California)
ABSTRACT In one embodiment, an expression system for expressing a UL128 complex is provided herein. The expression system may include a bacterial artificial chromosome (BAC) construct, wherein the BAC construct comprises a viral vector inserted with a set of DNA sequences that encode a UL128 complex. In another embodiment, a vaccine composition for preventing HCMV infection is provided. The vaccine composition may include a viral or bacterial vector capable of expressing a UL128 complex and a pharmaceutically acceptable carrier, adjuvant, additive or combination thereof or additional vector expressing a protein adjuvant. The viral vector may be an MVA and the UL128 complex includes five HCMV proteins or antigenic fragments thereof: UL128, UL130, UL131A, gL, and gH. In some embodiments, the viral vector is further inserted with one or more additional DNA sequences that encode one or more additional HCMVHCMV proteins or antigenic fragments thereof such as pp65, gB or both, or such as gM/gN or gO.
FILED Friday, November 20, 2020
APPL NO 17/100573
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/245 (20130101) Original (OR) Class
A61K 2039/5254 (20130101)

Peptides
C07K 14/005 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177967 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Rockville, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Rockville, Maryland)
INVENTOR(S) Wan Jun Chen (Bethesda, Maryland);  Shimpei Kasagi (Bethesda, Maryland);  Pin Zhang (Bethesda, Maryland)
ABSTRACT The disclosure provides methods of tolerizing or treating a subject suffering from an autoimmune or autoinflammatory disease or disorder to an antigen associated with the autoimmune disease or disorder. The disclosure also features kits for carrying out the methods.
FILED Thursday, February 04, 2021
APPL NO 17/167737
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/15 (20130101)
A61K 39/0007 (20130101)
A61K 39/0008 (20130101)
A61K 39/008 (20130101)
A61K 39/3955 (20130101) Original (OR) Class
A61K 45/06 (20130101)
A61K 2039/505 (20130101)
A61K 2039/507 (20130101)
A61K 2039/577 (20130101)
A61K 2039/55566 (20130101)
A61K 2300/00 (20130101)

Peptides
C07K 16/2812 (20130101)
C07K 16/2815 (20130101)
C07K 2317/73 (20130101)
C07K 2317/75 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177968 Gu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S) North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Zhen Gu (Raleigh, North Carolina);  Yanqi Ye (Raleigh, North Carolina)
ABSTRACT Embodiments of the present disclosure relate generally to photoimmunotherapy for treating cancer. More particularly, the present disclosure provides photo-responsive dermal applicators that use transdermal microneedle arrays to administer an immunogenic composition and a photo-sensitive biological pigment to a subject to treat and/or prevent cancer. Photo-responsive dermal applicators of the present disclosure provide the ability to target cancerous tumors in a manner that is safer and less invasive than conventional means.
FILED Thursday, October 25, 2018
APPL NO 16/759035
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0021 (20130101)
A61K 31/407 (20130101)
A61K 38/193 (20130101)
A61K 39/0011 (20130101)
A61K 39/00119 (20180801)
A61K 41/0057 (20130101) Original (OR) Class
A61K 45/06 (20130101)
A61K 47/36 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/062 (20130101)
A61N 2005/067 (20130101)
A61N 2005/0659 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177974 Taylor et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) NORTH CAROLINA CENTRAL UNIVERSITY (DURHAM, North Carolina)
ASSIGNEE(S) NORTH CAROLINA CENTRAL UNIVERSITY (Durham, North Carolina)
INVENTOR(S) Darlene K. Taylor (Burlington, North Carolina);  Melony A. Ochieng (Durham, North Carolina)
ABSTRACT A delivery system using materials that form a liquogel or nanocarrier are described. The delivery system comprises hyperbranched polyglycerols (HPGs). The delivery system can include a drug or therapeutic agent and this system can be used to administer the drug or therapeutic agent locally. The delivery system provides for controlled release of the drug or therapeutic agent.
FILED Friday, October 16, 2020
APPL NO 17/072804
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 9/0024 (20130101)
A61K 31/565 (20130101)
A61K 31/4745 (20130101)
A61K 47/34 (20130101) Original (OR) Class
A61K 47/59 (20170801)
A61K 47/551 (20170801)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 83/006 (20130101)

Compositions of Macromolecular Compounds
C08L 101/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177977 Kaplan et al.
FUNDED BY
Department of Defense (DOD)
Armed Forces Institute of Regenerative Medicine (AFIRM)
Department of the Army (DOA)
United States Army (USA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Tufts University (Medford, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) David L. Kaplan (Concord, Massachusetts);  Fiorenzo G. Omenetto (Lexington, Massachusetts);  Joseph E. Brown (Somerville, Massachusetts);  Rodrigo R. Jose (Medford, Massachusetts)
ABSTRACT The present application relates to silk fibroin-based materials, methods for making and using the same. Provided materials exhibit shape memory characteristics while showing comparable or better volumetric swelling, biocompatibility and/or degradability when compared to current memory polymers derived from either natural or synthetic materials.
FILED Friday, November 20, 2020
APPL NO 17/100376
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 2017/00867 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 47/26 (20130101)
A61K 47/42 (20130101) Original (OR) Class

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 31/146 (20130101)
A61L 2400/16 (20130101)

Peptides
C07K 14/43518 (20130101)
C07K 14/43586 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 9/0085 (20130101)
C08J 2389/00 (20130101)

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 4/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177979 Fu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Eye Institute (NEI)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Jie Fu (Baltimore, Maryland);  Peter A. Campochiaro (Baltimore, Maryland);  Justin Scot Hanes (Baltimore, Maryland)
ABSTRACT Non-linear multiblock copolymer-drug conjugates for the treatment and prevention of diseases and disorders of the eye are provided. The polymer-drug conjugates can form nanoparticles, microparticles, and implants that are capable of effectively delivering therapeutic levels of one or more active agents for an extended period of time. Administration to the eye of an active agent in the form of a non-linear multiblock copolymer-drug conjugate produces decreased side effects when compared to administration of the active agent alone. Also provided are methods of treating intraocular neovascular diseases, such as wet age-related macular degeneration as well as diseases and disorders of the eye associated with inflammation, such as uveitis.
FILED Wednesday, February 24, 2021
APPL NO 17/184152
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/59 (20170801)
A61K 47/60 (20170801) Original (OR) Class
A61K 47/6827 (20170801)
A61K 47/6927 (20170801)
A61K 47/6957 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177993 ACHILEFU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S) Samuel ACHILEFU (St. Louis, Missouri);  Rui TANG (St. Louis, Missouri);  Duanwen SHEN (St. Louis, Missouri);  Avik SOM (St. Louis, Missouri);  Baogang XU (St. Louis, Missouri);  Gail SUDLOW (St. Louis, Missouri);  Christopher EGBULEFU (St. Louis, Missouri);  Partha KARMAKAR (St. Louis, Missouri);  Kexian LIANG (St. Louis, Missouri)
ABSTRACT Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.
FILED Friday, December 11, 2020
APPL NO 17/119305
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/19 (20130101)
A61K 47/42 (20130101)
A61K 49/0034 (20130101) Original (OR) Class
A61K 49/0056 (20130101)
A61K 49/0089 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 69/105 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178017 Mauney et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Children's Medical Center Corporation (Boston, Massachusetts);  Tufts University (Medford, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Joshua R. Mauney (Watertown, Massachusetts);  Carlos R. Estrada (Brookline, Massachusetts);  David L. Kaplan (Concord, Massachusetts);  Eun Seok Gil (Lexington, Massachusetts)
ABSTRACT The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some embodiments, the compositions and methods described herein relate to wound healing, e.g. repair of wounds and/or tissue defects.
FILED Friday, February 05, 2021
APPL NO 17/169195
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/54 (20130101)
A61L 27/56 (20130101)
A61L 27/58 (20130101)
A61L 27/227 (20130101) Original (OR) Class
A61L 27/3604 (20130101)
A61L 27/3834 (20130101)
A61L 2300/22 (20130101)
A61L 2300/41 (20130101)
A61L 2300/43 (20130101)
A61L 2300/254 (20130101)
A61L 2300/256 (20130101)
A61L 2300/258 (20130101)
A61L 2300/406 (20130101)
A61L 2300/412 (20130101)
A61L 2300/414 (20130101)
A61L 2300/608 (20130101)
A61L 2430/22 (20130101)

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 39/003 (20130101)

Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles
B29L 2031/7532 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178024 RINALDI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) CARLOS RINALDI (GAINESVILLE, Florida);  CHRISTINE E. SCHMIDT (GAINESVILLE, Florida);  CHRISTOPHER LACKO (GAINESVILLE, Florida);  ZIN Z. KHAING (LAKE FOREST PARK, Washington);  ANDREW GARCIA (ORLANDO, Florida)
ABSTRACT The present disclosure provides magnetically templated tissue scaffolds, methods of making the magnetically templated tissue scaffolds, and various methods of employing the scaffolds for tissue growth and repair in vitro and in vivo, including peripheral nerve repair.
FILED Friday, January 29, 2021
APPL NO 17/161952
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/1128 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/20 (20130101)
A61L 27/24 (20130101)
A61L 27/26 (20130101)
A61L 27/52 (20130101)
A61L 27/56 (20130101) Original (OR) Class
A61L 27/58 (20130101)
A61L 2400/08 (20130101)
A61L 2430/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178140 WILSON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) EKOS CORPORATION (BOTHELL, Washington)
ASSIGNEE(S) EKOS CORPORATION (BOTHELL, Washington)
INVENTOR(S) RICHARD R. WILSON (SEATTLE, Washington);  ROBERT L. WILCOX (BOTHELL, Washington);  CURTIS GENSTLER (SNOHOMISH, Washington);  TIM ABRAHAMSON (SEATTLE, Washington);  WM. GERRIT BARRERE (LAKE FOREST PARK, Washington);  AMY COHEN (SEATTLE, Washington);  GEORGE KEILMAN (SEATTLE, Washington);  LEONARD R. OLIVER (SEATTLE, Washington);  NATALYA PESKIN (REDMOND, Washington)
ABSTRACT A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The ultrasonic catheter system comprises a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end, a fluid delivery lumen, at least one ultrasound radiating element positioned in the treatment zone, wiring electrically coupled to the at least one ultrasound radiating element and extending through the tubular body and terminating at a connector, and a control system comprising external circuitry and an isolation pod that is configured to be electrically connected to the connector, the isolation pod being positioned between the tubular body and the external system and comprising an isolation barrier and circuitry for driving the ultrasound radiating element.
FILED Tuesday, February 23, 2021
APPL NO 17/182981
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/2202 (20130101)
A61B 2017/22084 (20130101)
A61B 2017/22088 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 25/0029 (20130101)
A61M 25/0032 (20130101)
A61M 37/0092 (20130101) Original (OR) Class

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 7/00 (20130101)
A61N 2007/0078 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178178 TEDFORD
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) LumiThera, Inc. (Poulsbo, Washington)
ASSIGNEE(S)
INVENTOR(S) Clark E. TEDFORD (Poulsbo, Washington)
ABSTRACT Methods for treating ocular diseases such as dry age-related macular degeneration include administering non-invasive photobiomodulation light therapy in the context of a prior PBM treatment, on the basis of a subject response to prior PBM treatment, on the basis of a patient pre-treatment characteristic, and combinations thereof. In some embodiments, methods comprise administering PBM therapy to subjects who have received PBM about four to six months prior to the present administering. In some embodiments, methods comprise administering PBM therapy to subjects in early stages of dry age-related macular degeneration.
FILED Friday, November 02, 2018
APPL NO 16/761078
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/0613 (20130101) Original (OR) Class
A61N 2005/066 (20130101)
A61N 2005/0663 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178287 KOLESNICHENKO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Institute on Minority Health and Health Disparities (NIMHD)
APPLICANT(S) Xavier University of Louisiana (New Orleans, Louisiana)
ASSIGNEE(S)
INVENTOR(S) Vladimir KOLESNICHENKO (New Orleans, Louisiana);  Galina GOLOVERDA (New Orleans, Louisiana);  Igor KOLESNICHENKO (New Orleans, Louisiana);  Guangdi WANG (New Orleans, Louisiana)
ABSTRACT Disclosed are methods of solvent removal in an evacuated, closed system at ambient or low (spontaneously dropped due to evaporation endothermicity) temperature. The methods disclosed are suitable for removing the solvents with a broad range of volatility, having normal (STP) boiling points from 30 up to at least 202° C. (vapor pressures at least of 0.1 to 500 torr; higher boiling point solvents are possible to remove with longer experimental times) and is only limited from a volume standpoint by the size of the apparatus used.
FILED Thursday, December 10, 2020
APPL NO 17/118319
CURRENT CPC
Separation
B01D 3/10 (20130101)
B01D 11/0492 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178393 CRAIGHEAD et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S) CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S) Harold G. CRAIGHEAD (Ithaca, New York);  Sarah J. REINHOLT (Ithaca, New York)
ABSTRACT The present invention relates to, inter alia, a microfluidic device for capturing target cells and analyzing genomic DNA isolated from the target cells while under flow conditions. The microfluidic device includes a cell microchannel and a nucleic acid microchannel that intersect in an orthogonal manner, thereby forming a cell capture intersection region. The microfluidic device also includes a cell capture array and a nucleic acid entanglement array. The cell capture array includes a plurality of cell capturing micropillars and is located in the cell capture intersection region. The nucleic acid entanglement array includes a plurality of nucleic acid entanglement micropillars that function to physically entangle and maintain thereon genomic DNA isolated from the one or more target cell, and is located in a portion of the nucleic acid microchannel that is adjacent to and downstream of the cell capture intersection region. Methods of using the microfluidic device are also disclosed.
FILED Monday, May 22, 2017
APPL NO 16/303658
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502753 (20130101) Original (OR) Class
B01L 3/502761 (20130101)
B01L 2200/0663 (20130101)
B01L 2200/0668 (20130101)
B01L 2300/0816 (20130101)
B01L 2300/0864 (20130101)
B01L 2400/086 (20130101)
B01L 2400/0487 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179535 Ojima et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) The Research Foundation for The State University of New York (Albany, New York)
ASSIGNEE(S) The Research Foundation for The State University of New York (Albany, New York)
INVENTOR(S) Iwao Ojima (Port Jefferson, New York);  Dale Deutsch (Stony Brook, New York);  Martin Kaczocha (Dix Hills, New York);  Kongzhen Hu (Port Jefferson, New York);  Simon Tong (Great Neck, New York);  Matthew Elmes (Stony Brook, New York);  Su Yan (Stony Brook, New York)
ABSTRACT The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I)
FILED Thursday, February 11, 2021
APPL NO 17/174030
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 61/04 (20130101)
C07C 69/753 (20130101) Original (OR) Class
C07C 69/757 (20130101)
C07C 205/55 (20130101)
C07C 233/25 (20130101)
C07C 2601/04 (20170501)
C07C 2601/14 (20170501)
C07C 2601/16 (20170501)
C07C 2602/10 (20170501)
C07C 2603/18 (20170501)

Heterocyclic Compounds
C07D 215/06 (20130101)
C07D 249/06 (20130101)
C07D 309/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179597 Schnermann et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Martin J. Schnermann (Rockville, Maryland);  Venu G. Bandi (Frederick, Maryland)
ABSTRACT Cyanine fluorophores including a nine-carbon polymethine bridge are disclosed. The cyanine fluorophores have absorbance and/or emission maxima in the near-infrared (NIR) and short-wave infrared (SWIR) wavelength ranges. Methods of making and using the cyanine fluorophores are also disclosed. The compounds are useful in fluorescence imaging, more particularly in cancer treatment. The compounds have generic formula (I):
FILED Friday, August 23, 2019
APPL NO 17/269517
CURRENT CPC
Heterocyclic Compounds
C07D 209/18 (20130101)
C07D 403/14 (20130101)
C07D 405/14 (20130101)
C07D 409/14 (20130101) Original (OR) Class

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 23/0066 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179606 Hubin et al.
FUNDED BY
Department of Health and Human Services (HHS)
IDeA Networks of Biomedical Research Excellence (INBRE)
National Institutes of Health (NIH)
APPLICANT(S) Southwestern Oklahoma State University (Weatherford, Oklahoma);  University of Mississippi (University, Mississippi)
ASSIGNEE(S)
INVENTOR(S) Timothy J. Hubin (Weatherford, Oklahoma);  M.O. Faruk KHAN (Weatherford, Oklahoma);  Stephen James ARCHIBALD (Hull, United Kingdom);  Babu Lal TEKWANI (Oxford, Mississippi)
ABSTRACT Compositions are disclosed herein that include macrocycle derivatives incorporating bridged macrocycles. Also disclosed are methods of producing and using the compositions.
FILED Tuesday, October 20, 2020
APPL NO 17/075167
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/55 (20130101)
A61K 31/4985 (20130101)
A61K 31/4995 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/00 (20180101)
A61P 31/04 (20180101)

Heterocyclic Compounds
C07D 273/00 (20130101)
C07D 401/04 (20130101)
C07D 471/00 (20130101) Original (OR) Class
C07D 487/04 (20130101)
C07D 519/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/60 (20130101)
G01N 33/582 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179615 Mook et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Robert A. Mook (Chapel Hill, North Carolina);  Wei Chen (Chapel Hill, North Carolina);  Jiangbo Wang (Durham, North Carolina);  Xiu-Rong Ren (Durham, North Carolina);  Herbert Kim Lyerly (Chapel Hill, North Carolina)
ABSTRACT Described are niclosamide analogue compounds, pharmaceutical compositions thereof, and method of using the corner pounds and compositions for treating a disease associated with dysregulation of the Wnt/Frizzled signaling pathway, such as cancer, fatty liver, antibiotic resistance, and viral infection. The disclosed compounds and compositions may also be used for modulating mitochondrial function and for treating certain non-cancer diseases and/or diorders, such as diabetes, fibrotic disease, primary sclerosing cholangitis.
FILED Tuesday, July 30, 2019
APPL NO 17/263769
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/04 (20180101)

Heterocyclic Compounds
C07D 235/10 (20130101)
C07D 249/18 (20130101)
C07D 471/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179621 Yin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of Colorado, a body corporale (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Hang Hubert Yin (Boulder, Colorado);  Shuting Zhang (Boulder, Colorado);  Zhenyi Hu (Boulder, Colorado)
ABSTRACT Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.
FILED Tuesday, October 30, 2018
APPL NO 16/760815
CURRENT CPC
Heterocyclic Compounds
C07D 215/18 (20130101)
C07D 215/20 (20130101)
C07D 401/04 (20130101)
C07D 487/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179630 YANG et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPTARMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland);  YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Shyh Ming YANG (Doylestown, Pennsylvania);  David J. MALONEY (Points of Rocks, Maryland);  Natalia MARTINEZ (Rockville, Maryland);  Adam YASGAR (Washington, District of Columbia);  Anton SIMEONOV (Bethesda, Maryland);  Vasilis VASILIOU (Guilford, Connecticut)
ABSTRACT The disclosure provides compounds of Formula I, which may be useful as aldehyde dehydrogenase inhibitors and the pharmaceutically acceptable salts thereof. The variables, J, R4, G, Q, and ring A are defined herein. Aldehyde dehydrogenase inhibitors of Formula I are useful for treating a variety of conditions including cancer and inflammation The disclosure includes methods for using compounds and salts of Formula I to treat colon cancer, pancreatic cancer, nasopharyngeal carcinoma, thyroid cancer, prostate cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, hepatocellular carcinoma, leukemia, brain tumorsbreast cancer, atherosclerosis, ischaemic heart disease, acne vulgaris, asthma, autoimmune diseases, autoinflammatory diseases, chronic prostatitis, glomerulonephritis, inflammatory bowel disease, pelvic inflammatory disease, reperfusion injury, rheumatoid arthritis, sarcoidosis, transplant rejection, vasculitis, and interstitial cystitis. The disclosure also includes pharmaceutical compositions containing a compound or salt of Formula I.
FILED Tuesday, October 30, 2018
APPL NO 16/760345
CURRENT CPC
Heterocyclic Compounds
C07D 215/54 (20130101)
C07D 401/04 (20130101)
C07D 401/06 (20130101)
C07D 401/12 (20130101)
C07D 401/14 (20130101)
C07D 409/14 (20130101)
C07D 413/04 (20130101)
C07D 471/04 (20130101)
C07D 491/107 (20130101)
C07D 491/113 (20130101) Original (OR) Class
C07D 495/04 (20130101)
C07D 495/10 (20130101)
C07D 519/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179660 Arora et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Sloan-Kettering Institute for Cancer Research (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Vivek Arora (Olivette, Missouri);  Charles L. Sawyers (New York, New York);  Michael J. Evans (New York, New York);  Darren R. Veach (New York, New York)
ABSTRACT The present invention encompasses the recognition that reproducible and detectable changes in the level and or activity of Glucorticoid Receptor (GR) are associated with incidence and/or risk of Castration Resistant Prostrate Cancer (CRPC) and/or doubly resistant prostrate cancer, especially in individuals having prostrate cancer and on antiandrogen therapy, and provides for the use of GR inhibitors to treat and/or reduce risk of CRPC and/or doubly resistant prostrate cancer. In some embodiments, GR inhibitors also have Androgen Receptors (AR) inhibitory activity and or administered in conjunction with AR Inhibitors. The present invention also provides technologies for identification and/or characterization of agents to treat and/or reduce risk of CRPC and/or doubly resistant prostrate cancer; in some embodiments such agents alter level and/or activity of a GR. In some embodiments, provided agents show effects on a GR's activity of regulating transcription of one or more target genes. The present invention also provides systems for using such agents, for example to treat and/or reduce risk of CRPC and/or doubly resistant prostrate cancer.
FILED Tuesday, December 22, 2020
APPL NO 17/131134
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/58 (20130101)
A61K 31/416 (20130101)
A61K 31/573 (20130101)
A61K 31/575 (20130101)
A61K 31/713 (20130101)
A61K 31/4166 (20130101)
A61K 31/4439 (20130101)
A61K 31/5375 (20130101)
A61K 31/7105 (20130101)
A61K 45/06 (20130101)

Steroids
C07J 9/00 (20130101)
C07J 17/00 (20130101) Original (OR) Class
C07J 43/003 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/743 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179666 Haskell-Luevano et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S) Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S) Carrie Haskell-Luevano (Minneapolis, Minnesota);  Mark David Ericson (Minneapolis, Minnesota);  Zoe Margaret Koerperich (Minneapolis, Minnesota)
ABSTRACT Certain embodiments of the invention provide a cyclic compound of formula I: wherein Pro, DPro, X1, X2, X3, X4, X5, and X6 are defined as described herein; or a salt thereof. Certain embodiments also provide compositions comprising such compounds, as well as methods of using such compounds and compositions.
FILED Monday, December 07, 2020
APPL NO 17/113887
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 7/64 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179675 Verkhusha et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Vladislav V. Verkhusha (Bronx, New York);  Olena S. Oliinyk (Helsinki, Finland)
ASSIGNEE(S)
INVENTOR(S) Vladislav V. Verkhusha (Bronx, New York);  Olena S. Oliinyk (Helsinki, Finland)
ABSTRACT This invention provides the nucleic acid molecules encoding novel small monomeric near-infrared fluorescent protein miRFP670nano, variants and derivatives thereof as well as proteins and peptides encoded by these nucleic acids. The invention also relates to derivatives, homologues, or mutants of the specific proteins referenced above as well as fragments of the nucleic acids and the peptides encoded thereby. The invention further relates to host-cells, stable cell lines and transgenic organisms comprising above-referenced nucleic acid molecules. The present invention also refers to methods of making and using small monomeric near-infrared fluorescent proteins derived from cyanobacteriochromes. The presented protein and its derivatives find use in a variety of applications and approaches, including labeling of biomolecules, cells or cell organelles, detecting protein-protein interactions, and generation of genetically encoded fluorescent biosensors.
FILED Tuesday, December 08, 2020
APPL NO 17/115223
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0045 (20130101)

Peptides
C07K 14/405 (20130101) Original (OR) Class

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6816 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179692 Sivaramakrishnan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Sivaraj Sivaramakrishnan (North Oaks, Minnesota);  Keehun Kim (Minneapolis, Minnesota)
ABSTRACT The systems and methods described herein include the use of Giant Plasma Membrane Vesicles (GPMVs) derived from cells expressing SPASM sensors (e.g., SPASM GPCR sensors). Herein provided are giant plasma membrane vesicle (GPMV) M sensors containing a membrane-associated polypeptide, where the membrane-associated polypeptide contains a target G protein-coupled receptor (GPCR), a linker including an amino acid sequence flanked by a FRET donor and a FRET acceptor, and a receptor partner for the target GPCR, where the linker separates the target GPCR from the receptor partner. In another aspect, provided is a method for quantifying the intrinsic efficacy of a compound for a target GPCR. In another aspect, provided is a method for identifying a compound that interacts with a target GPCR.
FILED Tuesday, December 04, 2018
APPL NO 16/769852
CURRENT CPC
Peptides
C07K 14/723 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/68 (20130101)
G01N 33/542 (20130101)
G01N 33/566 (20130101)
G01N 2333/726 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179695 IBRAHIM et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (Torrance, California)
ASSIGNEE(S)
INVENTOR(S) Ashraf S. IBRAHIM (Torrance, California);  Sameh SOLIMAN (Torrance, California);  John EDWARDS, JR. (Torrance, California)
ABSTRACT Presented herein, in certain aspects, are compositions that comprise novel toxin proteins, the nucleic acids that encode them, and/or portions thereof, which toxins are expressed by fungi of the Mucorales order and are thought to contribute to the pathogenesis of Mucormycosis. Also presented herein, in certain aspects, are methods of detecting the presence or absence of novel fungal toxins and/or the nucleic adds that encode them in a sample, which methods can be used to identify the presence of Mucorales in a subject. Methods and/or compositions presented herein can be used to prevent and/or treat a Mucorales infection.
FILED Thursday, December 10, 2020
APPL NO 17/118594
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/10 (20180101)

Peptides
C07K 16/14 (20130101) Original (OR) Class

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6895 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56961 (20130101)
G01N 2333/37 (20130101)
G01N 2800/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179700 Baron et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
INVENTOR(S) Jeffrey Baron (Bethesda, Maryland);  Crystal Sao Fong Cheung (Bethesda, Maryland);  Julian Chun Kin Lui (Bethesda, Maryland);  Dimiter Dimitrov (Frederick, Maryland);  Zhongyu Zhu (Frederick, Maryland)
ABSTRACT Monoclonal antibodies and antibody fragments that specifically bind to matrilin-3, conjugates including these molecules, and nucleic acid molecules encoding the antibodies, antigen binding fragments and conjugates, are disclosed. Also disclosed are compositions including the disclosed antibodies, antigen binding fragments, conjugates, and nucleic acid molecules. Methods of treating or inhibiting a cartilage disorder in a subject, as well as methods of increasing chondrogenesis in cartilage tissue are further provided. The methods can be used, for example, for treating or inhibiting a growth plate disorder in a subject, such as a skeletal dysplasia or short stature.
FILED Wednesday, February 17, 2021
APPL NO 17/177644
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6811 (20170801)
A61K 47/6843 (20170801)

Peptides
C07K 14/78 (20130101)
C07K 16/18 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179714 WOLCHOK et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Jedd WOLCHOK (New York, New York);  Roberta ZAPPASODI (New York, New York);  Taha MERGHOUB (New York, New York)
ABSTRACT Increases in CD4+Foxp3PD-Ihi T cells (4PD1hi) in tumor-bearing hosts after CTLA-4 blockade show that these cells constitute an unconventional T-cell inhibitory subset with TFH-like features, which can affect the outcome of cancer immunotherapy. Evidence is provided that anti-PD-1/PD-L1 antibodies arc a viable option to control these cells. Furthermore, treating cancer by administering immune checkpoint blockade therapy and monitoring circulating 4PD1hi provides a more precise or personalized design of combination immunotherapies.
FILED Tuesday, November 06, 2018
APPL NO 16/761784
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/507 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/2818 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179725 Croft et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (La Jolla, California)
ASSIGNEE(S)
INVENTOR(S) Michael Croft (San Diego, California);  Taylor Doherty (San Diego, California);  Shahram Salek-Ardakani (San Diego, California)
ABSTRACT Methods of treating inflammatory conditions, disease and disorders are provided. Method include, for example, contacting or administering a sufficient amount of a LIGHT inhibitor to a subject to treat the inflammatory condition, disease or disorder.
FILED Wednesday, January 29, 2020
APPL NO 16/776371
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/007 (20130101)
A61K 31/00 (20130101)
A61K 38/191 (20130101)
A61K 39/3955 (20130101)
A61K 45/06 (20130101)
A61K 49/0004 (20130101)
A61K 2039/505 (20130101)

Peptides
C07K 16/2875 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179729 WELLS et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) James A. WELLS (San Francisco, California);  Alexander J. MARTINKO (San Francisco, California);  Juan E. DIAZ (San Francisco, California);  Michael J. HORNSBY (San Francisco, California)
ABSTRACT The disclosure is related to antibodies and antibody fragments that specifically bind the CUB domain-containing protein 1 (CDCP1) and their methods and uses in treating and detecting cancers.
FILED Thursday, October 25, 2018
APPL NO 16/759271
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6803 (20170801)
A61K 47/6849 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/2809 (20130101)
C07K 16/2896 (20130101) Original (OR) Class
C07K 2317/31 (20130101)
C07K 2317/92 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57492 (20130101)
G01N 2333/70596 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179989 Fernandez Vila et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Olaia Fernandez Vila (San Mateo, California);  Gordana Vunjak-Novakovic (New York, New York);  Stephen Ma (Layton, Utah);  Keith Yeager (Springfield Township, New Jersey)
ABSTRACT A system is provided for evaluating the function of the neuromuscular junction (NMJ) of a subject, which includes a platform including first and second culture chambers separated by a channel; the platform supporting a microtissue culture including: human skeletal myoblasts derived from the subject in the first chamber; a neurosphere derived from the subject, expressing an optogenetic protein in the second chamber, and a hydrogel in the channel to allow axonal sprouting and growth between the myoblasts and neurosphere. A light source is provided for optical stimulation pulses applied to the microtissue culture for activation of the optogenetic protein; and image recordation device for capturing images of the culture in response to the optical stimulation.
FILED Friday, December 11, 2020
APPL NO 17/118766
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/0622 (20130101)
A61N 2005/0663 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 21/08 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180023 OLSON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Board of Regents of the University of Texas System (Austin, Texas)
ASSIGNEE(S) The Board of Regents of the University of Texas System (Austin, Texas)
INVENTOR(S) Eric N. OLSON (University Park, Texas);  Huanyu ZHOU (Redwood City, Texas);  Rhonda BASSEL-DUBY (Dallas, Texas)
ABSTRACT The present disclosure involves the use of reprogramming factors including AKT1, GATA4, TBX5, MEF2C, HAND2 and either ZNF281 or AS-CL1 to reprogram adult non-cardiomyocytes, such as cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo. Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair.
FILED Monday, June 04, 2018
APPL NO 16/639523
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/10 (20180101)

Peptides
C07K 14/4702 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0657 (20130101) Original (OR) Class
C12N 9/12 (20130101)

Enzymes
C12Y 207/11001 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180035 Kornfeld et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Stuart Kornfeld (St. Louis, Missouri);  Lin Liu (St. Louis, Missouri);  Wang Lee (St. Louis, Missouri);  Balraj Doray (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Stuart Kornfeld (St. Louis, Missouri);  Lin Liu (St. Louis, Missouri);  Wang Lee (St. Louis, Missouri);  Balraj Doray (St. Louis, Missouri)
ABSTRACT The disclosure provides a modified UDP-GlcNAc:Lysosomal Enzyme GlcNAc-1-phosphotransferase with enhanced ability to phosphorylate lysosomal enzymes and methods of use thereof.
FILED Thursday, December 17, 2020
APPL NO 17/125480
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1288 (20130101) Original (OR) Class
C12N 9/2402 (20130101)

Enzymes
C12Y 207/08017 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180062 Huganir et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Richard Huganir (Baltimore, Maryland);  Ingie Hong (Baltimore, Maryland);  Yoichi Araki (Baltimore, Maryland)
ABSTRACT Disclosed are methods and compositions for treating a neurodevelopmental disorder in a subject in need thereof. In some aspects, the method includes administering an effective amount of an agent, wherein administering the agent modulates expression of one or more isoforms of synaptic GTPase-activating protein (SynGAP).
FILED Friday, October 30, 2020
APPL NO 17/085841
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/11 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180063 Webb et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S)
INVENTOR(S) Carol F. Webb (Oklahoma City, Oklahoma);  Julie Ward (Franklin, Massachusetts);  Michelle Ratliff (Oklahoma City, Oklahoma)
ABSTRACT Antisense compounds for suppressing expression of ARID3a are disclosed, as well as pharmaceutical compositions containing same and methods of producing and using same. The antisense compounds can be used to treat inflammatory disorders and conditions related to interferon-alpha production.
FILED Tuesday, December 01, 2020
APPL NO 17/108450
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/12 (20180101)
A61P 37/02 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/314 (20130101)
C12N 2310/351 (20130101)
C12N 2310/3233 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180067 Weiner et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
ASSIGNEE(S) UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
INVENTOR(S) George Weiner (Iowa City, Iowa);  William Thiel (Iowa City, Iowa);  Paloma Giangrande (Iowa City, Iowa);  Suresh Veeramani (Iowa City, Iowa);  Sue Blackwell (Iowa City, Iowa)
ABSTRACT Disclosed herein are compositions including an aptamer bound to a complex, wherein the complex comprises at least two polypeptides. Also disclosed are methods of quantifying a fraction of PD1 occupied by PDL1 or a fraction of PDL1 occupied by PD1 in a sample, and methods of isolating complexes using aptamers that are capable of binding to the complex.
FILED Monday, February 01, 2021
APPL NO 17/163761
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/549 (20170801)
A61K 47/642 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/55 (20130101)
C07K 14/7155 (20130101)
C07K 14/70532 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/115 (20130101) Original (OR) Class
C12N 2310/16 (20130101)
C12N 2320/13 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180087 Wagers et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Aging (NIA)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts);  Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Amy J. Wagers (Cambridge, Massachusetts);  Jill Goldstein (Cambridge, Massachusetts);  Leo Wang (La Canada Flintridge, California);  Ya-Chieh Hsu (Cambridge, Massachusetts);  Meryem Gonzalez Celeiro (Somerville, None)
ABSTRACT Disclosed are methods of in situ genomic modification of cells (e.g., stem cells, tissue stem cells, muscle stem cells, Sca-V mesenchymal progenitor cells in skeletal muscle, CD140a+ dermal mesenchymal cells) using sequence-targeting nucleases delivered via a virus (e.g., an AAV).
FILED Monday, August 19, 2019
APPL NO 17/269527
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 48/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 15/86 (20130101) Original (OR) Class
C12N 15/907 (20130101)
C12N 2310/20 (20170501)
C12N 2750/14143 (20130101)
C12N 2750/14171 (20130101)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180108 KIM et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Institute of Nursing Research (NINR)
APPLICANT(S) GoDx, Inc (Madison, Wisconsin);  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEP. OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
ASSIGNEE(S) GoDx, Inc (Madison, Wisconsin);  The United States of America, as Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
INVENTOR(S) Chang Hee KIM (Waunakee, Wisconsin);  Lichen XIANG (Bethesda, Maryland);  Wendy A. HENDERSON (Bethesda, Maryland);  Xiao JIANG (Madison, Wisconsin)
ABSTRACT Disclosed herein are method for separating, amplifying, or detecting a nucleic acid from a sample may comprise contacting a sample lysate with a plurality of buoyant, inorganic, nucleic-acid-capture microspheres. The nucleic-acid-capture microspheres may comprise unicellular hollow microspheres having a diameter between 5 and 300 μm and/or a true particle density between 0.05 and 0.60 grams/cm3. The microspheres may comprise hollow soda-lime-borosilicate microspheres. In some embodiments, the microspheres comprises hollow soda-lime-borosilicate microspheres surrounded by an amorphous silica shell. Also disclosed are kits for performing the methods.
FILED Monday, December 03, 2018
APPL NO 16/768802
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1006 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101) Original (OR) Class
C12Q 1/6865 (20130101)
C12Q 2527/125 (20130101)
C12Q 2531/113 (20130101)
C12Q 2531/143 (20130101)
C12Q 2563/155 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180127 CAI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Long CAI (Pasadena, California);  Chang Ho SOHN (Seoul, South Korea);  Yandong ZHANG (Pasadena, California)
ABSTRACT The present application describes compositions and methods for identifying and quantitating molecular targets within a cellular environment. Specifically, provided herein are compositions and methods for separately identifying and quantifying each of one or more molecular targets from a single cell. More specifically, provided herein are compositions and methods for separately identifying and quantifying the same molecular target from a single cell.
FILED Tuesday, November 24, 2020
APPL NO 17/103757
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101)
C12Q 1/6818 (20130101)
C12Q 1/6825 (20130101)
C12Q 1/6874 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180133 Garcia-Blanco et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S) Board of Regents, The University of Texas System (Austin, Texas);  Duke University (Durham, North Carolina);  Case Western Reserve University (Cleveland, Ohio);  University of California, Berkeley (Berkeley, California)
INVENTOR(S) Mariano A. Garcia-Blanco (Galveston, Texas);  Gaddiel Galarza-Munoz (Galveston, Texas);  Simon G. Gregory (Durham, North Carolina);  Farren B. S. Briggs (Cleveland Heights, Ohio);  Lisa F. Barcellos (El Cerrito, California);  Shelton S. Bradrick (Galveston, Texas);  Irina Evsyukova (Cedar Grove, North Carolina);  Dennis C. Ko (Durham, North Carolina)
ABSTRACT The present invention includes a method, kits, and assays for identifying a human subject as having an increased risk of developing an autoimmune disease, or a human subject with multiple sclerosis caused by elevated soluble Interleukin 7 receptor (sIL7R), by obtaining a biological sample and detecting or measuring in the biological sample an amount of a soluble Interleukin-7 receptor (sIL7R) and an amount of an RNA Helicase DDX39B, whereby a lower expression of DDX39B and a higher secretion of sIL7R identifies the subject from which the biological sample was obtained as having an increased risk of developing an autoimmune disease, when compared to a human subject not having an autoimmune disease. The present invention also includes a method of modifying a treating of subjects based on the lower expression of RNA Helicase DDX39B alone or in combination with an increase in sIL7R.
FILED Tuesday, February 23, 2021
APPL NO 17/182846
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/34 (20130101)
C12Q 1/6806 (20130101)
C12Q 1/6851 (20130101)
C12Q 1/6883 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180136 Delgado-Escueta et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Marco Tulio Medina-Hernandez (Los Angeles, California);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California);  RIKEN (SAITAMA, Japan);  INSTITUTO NACIONAL DE NEUROLOGIA Y NEUROCIRUGIA MANUEL VELASCO SUAREZ (DELEGACION TLALPAN, Mexico);  U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (WASHINGTON, District of Columbia)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California);  RIKEN (SAITAMA, Japan);  INSTITUTO NACIONAL DE NEUROLOGIA Y NEUROCIRUGIA MANUEL VELASCO SUAREZ (DELEGACION TLALPAN, Mexico);  U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (WASHINGTON, District of Columbia)
INVENTOR(S) Antonio V. Delgado-Escueta (MALIBU, California);  Kazuhiro Yamakawa (Saitama, Japan);  Toshimitsu Suzuki (SAITAMA, Japan);  Marco Tulio Medina-Hernandez (Tegucigalpa, Honduras);  Maria Elisa Alonso Vilatela (Delegacion Coyoacan, Mexico)
ABSTRACT Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1, EFHC1 agonists, or EFHC1 analogs are provided. Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1a, EFHC1a agonists, or EFHC1a analogs are provided.
FILED Monday, February 08, 2021
APPL NO 17/248798
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 2600/118 (20130101)
C12Q 2600/156 (20130101)
C12Q 2600/172 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180139 Elnitski et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
INVENTOR(S) Laura L. Elnitski (Gaithersburg, Maryland);  Gennady Margolin (Rockville, Maryland)
ABSTRACT The present application provides methods for the detection and diagnosis of cancer. In one aspect, the application provides methods for detecting the presence of cancer in an individual by detecting the methylation state of a region in the promoter of the ZNF154 gene. Methods are provided for detection and diagnosis of cancer from circulating tumor DNA which are minimally invasive and have diagnostic utility across different types and sub-types of cancer. In a further aspect, bioinformatics methods are provided to analyze the methylation state of the ZNF154 promoter and relate the methylation state to the likelihood of cancer in the individual.
FILED Thursday, February 18, 2021
APPL NO 17/179298
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/154 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181179 Salloum et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) MEMORIAL SLOAN KETTERING CANCER CENTER (New york, New York)
ASSIGNEE(S)
INVENTOR(S) Darin Salloum (New York, New York);  Bianca D. Santomasso (New York, New York);  Hans Guido Wendel (New York, New York)
ABSTRACT The present invention relates to the neurotoxicity that can occur as a side effect of the treatment of cancer patients with redirected T-cell therapies, such as chimeric antigen receptor (CAR) T cell therapies. The present invention provides various methods and compositions useful for treating and/or preventing such neurotoxicity, and/or for determining whether a subject is likely to develop such neurotoxicity, as well as a variety of other methods and compositions relating to the neurotoxicity associated with redirected T-cell therapies.
FILED Tuesday, May 28, 2019
APPL NO 17/058297
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)

Peptides
C07K 16/2866 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/505 (20130101) Original (OR) Class
G01N 33/5023 (20130101)
G01N 33/6896 (20130101)
G01N 2333/545 (20130101)
G01N 2333/5412 (20130101)
G01N 2333/5421 (20130101)
G01N 2800/28 (20130101)
G01N 2800/50 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181181 Liu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Xuedong Liu (Niwot, Colorado);  Douglas A. Chapnick (Boulder, Colorado);  William Old (Boulder, Colorado);  Tristan D. Mcclure-Begley (Falls Church, Virginia);  Eric Bunker (Derwood, Maryland)
ABSTRACT Provided are FRET-based biosensor constructs, and multiplexed platforms or arrays of these biosensor constructs useful for screening candidate drug molecules for efficacy and/or specificity of drug activity. Optionally the biosensor constructs may be located on an inner membrane within a cell or engineered to be located on the cell's surface. The cells or cell lines displaying the biosensors on a cell surface may be arranged as an array of cells for high throughput evaluation of the efficacy and/or specificity of drug candidates, such as a library of candidate drug compounds.
FILED Friday, December 14, 2018
APPL NO 16/954100
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/64 (20130101)
G01N 33/5008 (20130101) Original (OR) Class
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181182 Makarov et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) ATTAGENE, INC. (Research Triangle Park, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Sergei S. Makarov (Morrisville, North Carolina);  Alexander Vladimirovich Medvedev (Durham, North Carolina)
ABSTRACT Methodology is described for identification of perturbagens of biological processes and cell systems through transcription factor activity profiling. The method is based on the unexpected finding that perturbagens of a particular biological process or a cell system within living cells produce an invariant transcription factor activity profile (TFAP), regardless of where and how said perturbagens interfere. Such invariant TFAPs have been identified for perturbagens of multiple biological processes and cell systems, including mitochondria, HDAC, and proteasome inhibitors; DNA damaging agents; cytoskeleton disruptors; and kinase inhibitors. The discovery of such invariant TFAP signatures opens a vast spectrum of applications, including drug discovery and repurposing of approved drugs, and provides a new ontological basis for characterization of biological properties of myriad chemical and biological compounds.
FILED Tuesday, August 20, 2019
APPL NO 17/270005
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5008 (20130101) Original (OR) Class
G01N 33/6803 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181188 Carter et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
Office of the Director (NIHOD)
National Library of Medicine (NLM)
National Resource for Network Biology (NRNB)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Hannah Carter (San Diego, California);  Rachel Marty (San Diego, California);  Maurizio Zanetti (La Jolla, California);  Wesley Kurt Thompson (Arcadia, California);  Joan Font-Burgada (San Diego, California)
ABSTRACT The present disclosure provides methods of determining the risk of a subject having or developing a cancer based on the affinity of the subjects MHC-II alleles for oncogenic mutations, methods for improving cancer diagnosis, and kits comprising agents that detect the oncogenic mutations in a subject.
FILED Friday, August 23, 2019
APPL NO 17/270653
CURRENT CPC
Peptides
C07K 7/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5308 (20130101) Original (OR) Class
G01N 2333/70539 (20130101)
G01N 2800/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181190 Kumar et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland);  Yale University (New Haven, Connecticut)
ASSIGNEE(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland);  Yale University (New Haven, Connecticut)
INVENTOR(S) Sanjai Kumar (Potomac, Maryland);  Nitin Verma (Germantown, Maryland);  Ankit Puri (Rockville, Maryland);  Peter J. Krause (Old Saybrook, Connecticut)
ABSTRACT Identification of immunodominant Babesia microti antigens using genome-wide immunoscreening is described. Candidate antigens were screened against sera from patients with clinical babesiosis. Also described are diagnostic assays with high sensitivity and specificity for detecting B. microti-specific antibodies in patient samples using the identified immunodominant antigens.
FILED Thursday, November 01, 2018
APPL NO 16/761034
CURRENT CPC
Peptides
C07K 14/44 (20130101)
C07K 2319/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1096 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/54306 (20130101) Original (OR) Class
G01N 33/56905 (20130101)
G01N 2469/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181199 MARQUES, Jr. et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania);  YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S) University of Pittsburgh--of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania);  Yale University (New Haven, Connecticut)
INVENTOR(S) Ernesto Torres De Azeved MARQUES, Jr. (Pittsburgh, Pennsylvania);  Eduardo NASCIMENTO (Pittsburgh, Pennsylvania);  Albert Icksang KO (New Haven, Connecticut);  Donald S. BURKE (Pittsburgh, Pennsylvania)
ABSTRACT Disclosed are compositions and methods for the detection of a flavivirus infection. In some embodiments, the method comprises detecting a recent flavivirus infection by measuring the amount of anti-NS1 IgG3. In other embodiments, the method comprises detecting a prior Dengue virus infection in a subject previously immunized with a Dengue virus vaccine comprising one or more non-Dengue flavivirus proteins.
FILED Tuesday, May 08, 2018
APPL NO 16/611876
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/563 (20130101)
G01N 33/6854 (20130101)
G01N 33/56983 (20130101) Original (OR) Class
G01N 2333/185 (20130101)
G01N 2469/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181206 LI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Lingjun LI (Madison, Wisconsin);  Yatao SHI (Arlington, Massachusetts);  Zihui LI (Madison, Wisconsin)
ABSTRACT The present invention discloses mass spectrometry (MS)-based methods and tagging reagents for qualitative and quantitative analysis of post-translational modified (PTM) proteins in biological and clinical samples. The present invention utilizes thiol-containing tagging reagents which are able to bind to or derivatize biomolecules, preferably post-translational modified (PTM) polypeptides such as citrullinated and homocitrullinated polypeptides. The tagging reagents are preferably biotin-derived tags able to react with a side chain of the modified polypeptides.
FILED Monday, December 14, 2020
APPL NO 17/121242
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6848 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181214 Flaumenhaft et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
ASSIGNEE(S) Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
INVENTOR(S) Robert Flaumenhaft (Boston, Massachusetts);  David Barrios (Brighton, Massachusetts);  Secil Koseoglu (Somerville, Massachusetts)
ABSTRACT In some aspects, the disclosure relates to compositions and methods for detecting phosphorylation of dynamin-related protein 1 (Dip1) at position Ser-616. In some embodiments, methods described by the disclosure are useful for detecting antiplatelet agent sensitivity in a subject. In some embodiments, methods described by the disclosure are useful for detecting if a subject has been previously exposed to an antiplatelet agent.
FILED Friday, August 23, 2019
APPL NO 17/270830
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/86 (20130101) Original (OR) Class
G01N 33/6803 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181275 Barnes
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Alexander Barnes (St. Louis, Missouri)
ABSTRACT Among the various aspects of the present disclosure is the provision of systems and spherical rotors suitable for use in magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and methods of use thereof.
FILED Thursday, November 29, 2018
APPL NO 16/768801
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/31 (20130101)
G01R 33/46 (20130101)
G01R 33/307 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181490 Liu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Jonathan T.C. Liu (Seattle, Washington);  Lingpeng Wei (Seattle, Washington);  Chengbo Yin (Seattle, Washington)
ABSTRACT Apparatuses, systems, and methods for dynamically shaped focal surface with a scanning microscope. A microscope (e.g., a scanning confocal microscope) may use a scanning element to scan an illumination beam to generate a focal region. The scanning element may include multiple degrees of freedom, such as rotation and translation along orthogonal axes. For example, if the illumination beam is a line focus, rotation along a first axis and translation along a second orthogonal axis may sweep the line focus across a focal surface which is substantially flat and normal to the second axis. In some embodiments, the microscope may be a dual-axis handheld microscope, where a single objective in a handheld housing is used to both direct the scanned illumination beam and receive the collected light.
FILED Tuesday, December 15, 2020
APPL NO 17/122697
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/008 (20130101)
G02B 21/0032 (20130101)
G02B 21/0048 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181673 Ozcan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Office of the Director (NIHOD)
National Science Foundation (NSF)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Aydogan Ozcan (Los Angeles, California);  Alon Grinbaum (Durham, North Carolina);  Yibo Zhang (Los Angeles, California);  Alborz Feizi (Chino, California);  Wei Luo (Los Angeles, California)
ABSTRACT A method for lens-free imaging of a sample or objects within the sample uses multi-height iterative phase retrieval and rotational field transformations to perform wide FOV imaging of pathology samples with clinically comparable image quality to a benchtop lens-based microscope. The solution of the transport-of-intensity (TIE) equation is used as an initial guess in the phase recovery process to speed the image recovery process. The holographically reconstructed image can be digitally focused at any depth within the object FOV (after image capture) without the need for any focus adjustment, and is also digitally corrected for artifacts arising from uncontrolled tilting and height variations between the sample and sensor planes. In an alternative embodiment, a synthetic aperture approach is used with multi-angle iterative phase retrieval to perform wide FOV imaging of pathology samples and increase the effective numerical aperture of the image.
FILED Thursday, November 19, 2020
APPL NO 16/952492
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1429 (20130101)
G01N 15/1434 (20130101)
G01N 15/1475 (20130101)
G01N 2015/1006 (20130101)

Holographic Processes or Apparatus
G03H 1/0005 (20130101) Original (OR) Class
G03H 1/0443 (20130101)
G03H 1/0866 (20130101)
G03H 1/0891 (20130101)

Pictorial Communication, e.g Television
H04N 5/2256 (20130101)
H04N 5/23238 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182601 FRANK et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Lawrence R. FRANK (San Diego, California);  Vitaly L. GALINSKY (San Diego, California)
ABSTRACT A method for analysis of complex spatio-temporal data within a dynamic system that includes spatial positions and fields, at least a portion of which are interacting, includes determining values of mean field at every spatial position, determining spatio-temporal eigenmodes in spatial-frequency space assuming interacting fields, and determining spatial and temporal interactions between the eigenmodes. The resulting display indicates space/time localization patterns that are indicative of connectivity within the dynamic system.
FILED Sunday, January 31, 2021
APPL NO 17/163481
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/00 (20130101)
A61B 5/055 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/4806 (20130101)
G01R 33/5608 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00536 (20130101)
G06K 9/6214 (20130101) Original (OR) Class
G06K 9/6247 (20130101)
G06K 9/6271 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 2207/10088 (20130101)
G06T 2207/30016 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210183467 GOODMAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S) YALE UNIVERSITY (New Haven, Connecticut)
INVENTOR(S) Andrew GOODMAN (Guilford, Connecticut);  Michael ZIMMERMANN (New Haven, Connecticut);  Maria ZIMMERMANN (New Haven, Connecticut)
ABSTRACT The invention provides a system and method to quantitatively disentangle host and microbiome contributions to drug metabolism. The system includes a non-transitory storage medium storing information of levels of parent drug and drug metabolites for a plurality of oral drugs, by each of a plurality of microbiotas and by each of a plurality of genome-sequenced microbes in pure culture. A processor executes a predictor module which implements a computational model to quantitatively disentangle host and microbiota contributions to drug metabolism, predict how a person's microbiome will metabolize a drug candidate, predict how the metabolization impacts the drug candidate and metabolite exposure in circulation, and predict whether the drug candidate will be metabolized by a microbiota.
FILED Friday, June 28, 2019
APPL NO 17/257394
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/10 (20190201)
G16B 20/50 (20190201) Original (OR) Class
G16B 40/20 (20190201)
G16B 40/30 (20190201)

Computational Chemistry; Chemoinformatics; Computational Materials Science
G16C 20/70 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20210177383 Moga et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
APPLICANT(S) Tasso, Inc. (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Ben Moga (Soquel, California);  Ben Casavant (Seattle, Washington);  Erwin Berthier (Seattle, Washington)
ABSTRACT The disclosed apparatus, systems and methods relate to devices, systems and methods for the collection of bodily fluids. The collector can make use of microfluidic networks connected to collection sites on the skin of a subject to gather and shuttle blood into a removable cartridge. The collected fluid is supplied to substrate for drying, storage and transport.
FILED Friday, February 26, 2021
APPL NO 17/186483
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/150022 (20130101)
A61B 5/150068 (20130101)
A61B 5/150251 (20130101)
A61B 5/150343 (20130101)
A61B 5/150366 (20130101)
A61B 10/0038 (20130101)
A61B 10/0045 (20130101) Original (OR) Class
A61B 10/0096 (20130101)
A61B 2503/42 (20130101)

Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502 (20130101)
B01L 3/5023 (20130101)
B01L 2200/18 (20130101)
B01L 2300/069 (20130101)
B01L 2300/0816 (20130101)
B01L 2400/0406 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177770 SAILOR et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Eye Institute (NEI)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) SPINNAKER BIOSCIENCES, INC. (Solana Beach, California);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S) SPINNAKER BIOSCIENCES, INC. (Solana Beach, California);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S) Michael J. SAILOR (La Jolla, California);  Jinyoung KANG (La Jolla, California);  Jinmyoung JOO (Seoul, South Korea);  Emily ANGLIN (San Marcos, California);  Ester KWON (Cambridge, Massachusetts);  Matthew SKALAK (Boston, Massachusetts);  Sangeeta BHATIA (Lexington, Massachusetts)
ABSTRACT Compositions useful in the controlled delivery of therapeutic agents and their methods of preparation and use are provided. The compositions comprise an optionally oxidized porous silicon core, a layer on the surface of the porous silicon core that comprises a metal silicate, and a therapeutic agent. The compositions optionally further comprise one or more targeting agents and/or cell-penetrating agents to enable the particles to target and enter cells or tissues of interest in a treated subject.
FILED Friday, April 14, 2017
APPL NO 16/093131
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5115 (20130101) Original (OR) Class
A61K 9/5192 (20130101)
A61K 38/17 (20130101)
A61K 38/162 (20130101)
A61K 49/0004 (20130101)
A61K 49/0013 (20130101)
A61K 49/0093 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)
C12N 2310/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177832 CHOUDHARY et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Department of the Navy (DON)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Amit CHOUDHARY (Boston, Massachusetts);  Basudeb MAJI (Cambridge, Massachusetts);  Soumyashree Ashok GANGOPADHYAY (Boston, Massachusetts);  Miseon LEE (Cambridge, Massachusetts);  Mengchao SHI (Boston, Massachusetts)
ABSTRACT Compositions and methods for inhibiting the activity of RNA-guided endonucleases, and methods for identifying such compositions are included. Methods of treatment using the inhibitory compounds, formulations and methods are also detailed, as well as control of nucleic acid editing systems and methods using said compounds.
FILED Tuesday, August 20, 2019
APPL NO 17/269900
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4745 (20130101) Original (OR) Class
A61K 31/7105 (20130101)
A61K 38/465 (20130101)
A61K 47/54 (20170801)
A61K 47/545 (20170801)

Heterocyclic Compounds
C07D 471/04 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/99 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177977 Kaplan et al.
FUNDED BY
Department of Defense (DOD)
Armed Forces Institute of Regenerative Medicine (AFIRM)
Department of the Army (DOA)
United States Army (USA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Tufts University (Medford, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) David L. Kaplan (Concord, Massachusetts);  Fiorenzo G. Omenetto (Lexington, Massachusetts);  Joseph E. Brown (Somerville, Massachusetts);  Rodrigo R. Jose (Medford, Massachusetts)
ABSTRACT The present application relates to silk fibroin-based materials, methods for making and using the same. Provided materials exhibit shape memory characteristics while showing comparable or better volumetric swelling, biocompatibility and/or degradability when compared to current memory polymers derived from either natural or synthetic materials.
FILED Friday, November 20, 2020
APPL NO 17/100376
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 2017/00867 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 47/26 (20130101)
A61K 47/42 (20130101) Original (OR) Class

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 31/146 (20130101)
A61L 2400/16 (20130101)

Peptides
C07K 14/43518 (20130101)
C07K 14/43586 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 9/0085 (20130101)
C08J 2389/00 (20130101)

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 4/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178324 McDonald et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) MOSAIC MATERIALS, INC (Alameda, California)
ASSIGNEE(S) MOSAIC MATERIALS, INC. (Alameda, California)
INVENTOR(S) Thomas Michael McDonald (Alameda, California);  Graham Benjamin Wenz (Alameda, California)
ABSTRACT The present disclosure relates to improved solid state sorbent materials and methods for controlling and enhancing carbon dioxide adsorption performance for selected metal-organic framework (MOF) materials. The present disclosure further relates to inventive methods using a novel class of diamine-appended metal-organic frameworks MOF absorbents displaying step-shaped adsorption isotherms with large carbon dioxide capacities. More specifically, the present disclosure relates to diamine-appended MOF materials exhibiting step-shaped adsorption isotherms that are employed in a method utilizing humidity to control and improve carbon dioxide adsorption performance. In addition, the present disclosure relates to diamine-appended MOF materials used in a process including a regeneration step with carbon dioxide and humidity level control to achieve deep carbon dioxide removal even from dilute, near ambient condition carbon dioxide streams as well as more concentrated industrial output streams spanning multiple orders of magnitude. The present disclosure also relates to scrubbing apparatus and methods employing the inventive MOF materials, methods, process steps and apparatus as disclosed to achieve rapid and deeper carbon dioxide capture without the need to pretreat column materials.
FILED Monday, December 14, 2020
APPL NO 17/120796
CURRENT CPC
Separation
B01D 53/62 (20130101) Original (OR) Class
B01D 53/0462 (20130101)
B01D 2253/204 (20130101)
B01D 2257/504 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/226 (20130101)
B01J 20/3425 (20130101)
B01J 20/3466 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178339 Glover
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Thomas Grant Glover (Spanish Fort, Alabama)
ASSIGNEE(S)
INVENTOR(S) Thomas Grant Glover (Spanish Fort, Alabama)
ABSTRACT A method of encapsulating an engineered pellet in a porous membrane is disclosed. The method includes the steps of: (i) dissolving a membrane solute in a membrane solvent to produce a membrane solution; (ii) applying the membrane solution to a pellet to form a pellet encapsulated with the membrane solution; (iii) subjecting the membrane solution that encapsulates the pellet to a phase inversion and; (iv) drying the pellet to form a porous membrane encapsulated pellet. A porous membrane encapsulated pellet is also described.
FILED Tuesday, December 15, 2020
APPL NO 17/121974
CURRENT CPC
Separation
B01D 53/08 (20130101)
B01D 53/1475 (20130101)
B01D 67/0002 (20130101)
B01D 69/141 (20130101) Original (OR) Class
B01D 2325/02 (20130101)
B01D 2325/14 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/226 (20130101)
B01J 20/262 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178340 Knauss et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) Daniel M. Knauss (Golden, Colorado);  Derek J. Strasser (Parker, Colorado)
ASSIGNEE(S)
INVENTOR(S) Daniel M. Knauss (Golden, Colorado);  Derek J. Strasser (Parker, Colorado)
ABSTRACT The invention relates to membranes, monomers and polymers. The monomers can form polymers, which can be used for membranes. The membranes can be used in alkaline fuel cells, for water purification, for electrolysis, for flow batteries, and for anti-bacterial membranes and materials, as well as membrane electrode assemblies for fuel cells. In addition to the membranes, polymers and monomers and methods of using the membranes, the present invention also relates to methods of making the membranes, monomers and polymers.
FILED Friday, February 19, 2021
APPL NO 17/180629
CURRENT CPC
Separation
B01D 67/0009 (20130101)
B01D 67/0013 (20130101)
B01D 67/0093 (20130101)
B01D 71/62 (20130101) Original (OR) Class
B01D 71/76 (20130101)
B01D 71/80 (20130101)
B01D 71/82 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 75/20 (20130101)
C08G 75/045 (20130101)
C08G 81/024 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/2262 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/38 (20130101)

Compositions of Macromolecular Compounds
C08L 53/00 (20130101)
C08L 81/02 (20130101)
C08L 81/06 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 8/1032 (20130101)
H01M 8/1067 (20130101)
H01M 8/1072 (20130101)
H01M 8/1081 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178510 Lee et al.
FUNDED BY
Department of Defense (DOD)
Missile Defense Agency (MDA)
APPLICANT(S) PHYSICAL OPTICS CORPORATION (Torrance, California)
ASSIGNEE(S)
INVENTOR(S) Kang Lee (Torrance, California);  Matthew Neil (Torrance, California);  Wayne Chan (Torrance, California);  Anthony Lai (Torrance, California);  Andrew Kostrzewski (Torrance, California)
ABSTRACT Systems and techniques are directed to a Swappable Retractable Tool Tip (SRTT), which is designed as a next generation of friction stir welding tools and retractable tool tips. The disclosed SRTT may be “swappable,” having different types of retractable tool tips that can be assembled and employed as a part of the SRTT. A SRTT system can include at least: a blank tool holder, a piston, and a retractable tool tip. In operation, the blank tool holder allows air to flow to cause movement of the piston and the retractable tool tip. For example, compressed air can push up on the piston and the retractable tool tip, retracting it into a “home” position inside of the blank tool holder. Also, the SRTT can include springs that push down on the piston and the retractable tool tip, extending the tip into an “extended” position outside of the blank tool holder.
FILED Thursday, December 17, 2020
APPL NO 17/125692
CURRENT CPC
Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam
B23K 20/123 (20130101)
B23K 20/1255 (20130101) Original (OR) Class

Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 19/4145 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178636 LeDuc et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Army (DOA)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania);  University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S) Philip R. LeDuc (Wexford, Pennsylvania);  O. Burak Ozdoganlar (Sewickley, Pennsylvania);  Mary E. Wilson (Baltimore, Maryland);  Emrullah Korkmaz (Pittsburgh, Pennsylvania);  Yadong Wang (Pittsburgh, Pennsylvania);  Donna Beer-Stolz (Pittsburgh, Pennsylvania)
ABSTRACT The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a shape that mimics a biological network. Cellular material can be seeded around the template or a space created by the template and grown into an engineered tissue-construct.
FILED Monday, February 08, 2021
APPL NO 17/170706
CURRENT CPC
Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics
B29B 11/14 (20130101) Original (OR) Class

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 33/3842 (20130101)

Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles
B29L 2031/7534 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178725 Xu
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S)
INVENTOR(S) Chengying Xu (Cary, North Carolina)
ABSTRACT Composite materials are provided which may include one or more sheets of carbon fibers woven in orthogonal direction bundles; carbon nanotubes embedded within pores between the bundles; and a matrix material in which the one or more sheets and the carbon nanotubes are embedded. In one case, the carbon fibers lie substantially in an x-direction and a y-direction and the carbon nanotubes are oriented substantially in a z-direction, which is substantially perpendicular to the x- and y-directions. Methods for making the composite materials are also provided.
FILED Monday, October 12, 2020
APPL NO 17/067925
CURRENT CPC
Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 5/00 (20130101)
B32B 5/06 (20130101)
B32B 5/08 (20130101)
B32B 5/024 (20130101)
B32B 5/26 (20130101) Original (OR) Class
B32B 38/08 (20130101)
B32B 2260/04 (20130101)
B32B 2260/021 (20130101)
B32B 2260/023 (20130101)
B32B 2307/558 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179200 Leonard et al.
FUNDED BY
Department of Defense (DOD)
United States Special Operations Command (SOCOM)
U.S. Special Operations Command (USSOCOM)
APPLICANT(S) Polaris Industries Inc. (Medina, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Joshua J. Leonard (North Branch, Minnesota);  Richard Raymond Maki (North Branch, Minnesota);  Eric Bjerketvedt (North Branch, Minnesota);  Michael D. Schneider (Dalbo, Minnesota);  Bradley Robert Morisch (Lindstrom, Minnesota);  Brian D. Krosschell (Chisago City, Minnesota)
ABSTRACT A vehicle is disclosed. The vehicle may include a base portion and a modular portion. The base portion may be a four wheel vehicle having an operator area with seating for at least two occupants in a side-by-side arrangement. The modular portion may be coupled to the base portion resulting in a six wheel vehicle. The wheels of the modular portion may be powered by an engine of the base portion.
FILED Wednesday, February 24, 2021
APPL NO 17/184167
CURRENT CPC
Vehicle Suspension Arrangements
B60G 3/20 (20130101)
B60G 15/06 (20130101)
B60G 15/067 (20130101)
B60G 2200/144 (20130101)
B60G 2202/24 (20130101)
B60G 2206/011 (20130101)
B60G 2206/0114 (20130101)
B60G 2300/13 (20130101)

Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles
B60K 17/16 (20130101)

Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for
B60R 21/13 (20130101)

Motor Vehicles; Trailers
B62D 21/12 (20130101)
B62D 21/14 (20130101)
B62D 21/183 (20130101)
B62D 33/063 (20130101) Original (OR) Class
B62D 33/067 (20130101)
B62D 33/077 (20130101)
B62D 55/04 (20130101)
B62D 61/10 (20130101)
B62D 61/12 (20130101)
B62D 63/025 (20130101)

Couplings for Transmitting Rotation; Clutches; Brakes
F16D 55/226 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179242 Seeley et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The United States of America as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) Eric Seeley (Seabeck, Washington);  Jennifer Guild (Poulsbo, Washington)
ABSTRACT A field configurable autonomous vehicle includes modular elements and attachable components. The vehicle can be assembled from these modular elements and components to meet desired mission and performance characteristics without the need to purchase specially designed vehicles for each mission. The vehicle can include a mechanisms that magnetically attaches to a ferry vehicle for transport to the location of use.
FILED Saturday, September 12, 2020
APPL NO 16/974040
CURRENT CPC
Motor Vehicles; Trailers
B62D 27/06 (20130101)

Ships or Other Waterborne Vessels; Equipment for Shipping
B63B 21/02 (20130101)

Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers
B63G 8/001 (20130101) Original (OR) Class
B63G 8/42 (20130101)

Dynamo-electric Machines
H02K 11/215 (20160101)
H02K 49/108 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179258 OL et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Secretary of the Air Force (SECAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S) Michael V. OL (Xenia, Ohio);  Alberto Medina (Fairborn, Ohio)
ABSTRACT A wing, a method of controlling lift on a wing, and a system to produce lift on a wing are provided. The wing may include a fore-element, an aft-element, a pivotable linkage that operatively connects the aft-element leading edge to the fore-element trailing edge in a span-wise direction, and an actuator. The actuator may deflect the aft-element through a predetermined deflection angle about the pivotable linkage relative to the fore-element within less than or equal to two convective periods. The method may include deflecting a span-wise flap through the deflection angle in less than or equal to two convective periods to produce high lift. The system may include a sensor to detect an input and a controller to deflect the span-wise flap of the wing by the deflection angle in not more than two convective periods based on the received input signal.
FILED Tuesday, March 02, 2021
APPL NO 17/189363
CURRENT CPC
Ships or Other Waterborne Vessels; Equipment for Shipping
B63B 1/28 (20130101)
B63B 1/248 (20130101)

Aeroplanes; Helicopters
B64C 3/48 (20130101)
B64C 9/28 (20130101) Original (OR) Class
B64C 13/16 (20130101)
B64C 13/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179509 BANISH et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) KNOWFLAME, INC. (Huntsville, Alabama)
ASSIGNEE(S)
INVENTOR(S) R Michael BANISH (Huntsville, Alabama);  Peter S. ERBACH (Huntsville, Alabama)
ABSTRACT A method and device of the present disclosure produces a non-incendiary, organic-polymerization based, smoke-producing reaction. The smoke mainly comprises thermal decomposition products of the initiator compound. A composition for the non-pyrotechnic generation of smoke is provided that includes a monomer that exothermically polymerizes, and an initiator, such that smoke is generated during a frontal polymerization reaction.
FILED Wednesday, December 30, 2020
APPL NO 17/137940
CURRENT CPC
Means for Generating Smoke or Mist; Gas-attack Compositions; Generation of Gas for Blasting or Propulsion
C06D 3/00 (20130101) Original (OR) Class

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 2/44 (20130101)
C08F 22/1006 (20200201)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/36 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179583 JI
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) H LEE MOFFTT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tanpa, Florida)
ASSIGNEE(S)
INVENTOR(S) Haitao JI (Tampa, Florida)
ABSTRACT Disclosed are inhibitors for the β-catenin/BCL9 interaction. The inhibitors are selective for β-catenin/BCL9 over β-catenin/cadherin interactions. Methods of using the disclosed compounds to treat cancer are also disclosed.
FILED Monday, December 17, 2018
APPL NO 16/954095
CURRENT CPC
Heterocyclic Compounds
C07D 401/12 (20130101)
C07D 401/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179772 Nuckolls et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
INVENTOR(S) Colin Nuckolls (New York, New York);  Xavier Sylain Roy (New York, New York);  Yuan Yang (New York, New York);  Thomas Sisto (New York, New York);  Samuel Robert Peurifoy (New York, New York);  Jake Carter Russell (New York, New York)
ABSTRACT Methods for making electron accepting polymers, and polymers made thereby, are disclosed. The polymer can include a perylene diimide (PDI) subunit and a triptycene subunit. The disclosed polymer can accept an electron and be used as a pseudocapacitor material.
FILED Monday, February 22, 2021
APPL NO 17/181704
CURRENT CPC
Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 61/122 (20130101) Original (OR) Class
C08G 2261/90 (20130101)
C08G 2261/124 (20130101)
C08G 2261/411 (20130101)
C08G 2261/3142 (20130101)
C08G 2261/3241 (20130101)

Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 11/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179807 Ren et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Laboratory (ARL)
Army Research Office (ARO)
APPLICANT(S) Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Shenqiang Ren (Haverford, Pennsylvania);  Simona Percec (Philadelphia, Pennsylvania);  Zhuolei Zhang (Philadelphia, Pennsylvania)
ABSTRACT A method of fabricating a polymer composite material by mixing a polymer material with a planar material, depositing the mixture on a substrate, and stretching the resulting thin film, is described. Polymer composite materials produced using said method and ballistic resistant materials comprising said polymer composite materials are also described.
FILED Wednesday, December 12, 2018
APPL NO 16/770825
CURRENT CPC
Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics
B29B 7/90 (20130101)

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 41/006 (20130101)
B29C 55/04 (20130101)
B29C 55/005 (20130101)
B29C 55/18 (20130101)

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2507/04 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 110/02 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/212 (20130101)
C08J 2323/06 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/38 (20130101) Original (OR) Class
C08K 2003/385 (20130101)

Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General
F41H 5/0485 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179989 Fernandez Vila et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Olaia Fernandez Vila (San Mateo, California);  Gordana Vunjak-Novakovic (New York, New York);  Stephen Ma (Layton, Utah);  Keith Yeager (Springfield Township, New Jersey)
ABSTRACT A system is provided for evaluating the function of the neuromuscular junction (NMJ) of a subject, which includes a platform including first and second culture chambers separated by a channel; the platform supporting a microtissue culture including: human skeletal myoblasts derived from the subject in the first chamber; a neurosphere derived from the subject, expressing an optogenetic protein in the second chamber, and a hydrogel in the channel to allow axonal sprouting and growth between the myoblasts and neurosphere. A light source is provided for optical stimulation pulses applied to the microtissue culture for activation of the optogenetic protein; and image recordation device for capturing images of the culture in response to the optical stimulation.
FILED Friday, December 11, 2020
APPL NO 17/118766
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/0622 (20130101)
A61N 2005/0663 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 21/08 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180096 Tracewell et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Zymergen Inc. (Emeryville, California)
ASSIGNEE(S) Zymergen Inc. (Emeryville, California)
INVENTOR(S) Cara Ann Tracewell (Walnut Creek, California);  Alexander Glennon Shearer (San Francisco, California);  Michael Shareef Siddiqui (Oakland, California);  Steven M. Edgar (Albany, California);  Nicolaus Herman (El Cerrito, California);  Murtaza Shabbir Hussain (Emeryville, California)
ABSTRACT The present disclosure describes the engineering of microbial cells for fermentative production of histamine and provides novel engineered microbial cells and cultures, as well as related histamine production methods.
FILED Friday, April 19, 2019
APPL NO 17/048553
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/18 (20130101)
C12N 1/20 (20130101)
C12N 9/0006 (20130101)
C12N 9/88 (20130101)
C12N 9/1077 (20130101)
C12N 15/77 (20130101)
C12N 15/81 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 17/10 (20130101) Original (OR) Class

Enzymes
C12Y 101/01049 (20130101)
C12Y 204/02017 (20130101)
C12Y 401/01022 (20130101)
C12Y 402/01019 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180317 Shields
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Engineer Research and Development Center (ERDC)
APPLICANT(S) SELECT ENGINEERING SERVICES (Layton, Utah)
ASSIGNEE(S)
INVENTOR(S) David Eugene Shields (Layton, Utah)
ABSTRACT Rigid wall shelters are used throughout the world for shipping, living quarters, and housing for electronic systems and are energy inefficient. While investigating energy-efficient technologies for rigid wall shelters the discovery was made to insulate the outside of the shelter rather than the inside. Space is often limited inside of the shelter. The invention of an external, re-deployable insulation system was developed. The present invention is an insulating system composed of three main components. The first component is multiple, flexible envelopes filled with insulating materials (which creates a panel). The second component is multiple insulating strips that cover the joint between the panels. The final component is a weatherproof outer covering that protects the entire system from the elements.
FILED Wednesday, September 16, 2020
APPL NO 17/023050
CURRENT CPC
General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings
E04B 1/80 (20130101)
E04B 1/86 (20130101)
E04B 1/92 (20130101)
E04B 1/762 (20130101) Original (OR) Class

Finishing Work on Buildings, e.g Stairs, Floors
E04F 13/002 (20130101)

Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General
E04H 1/1205 (20130101)
E04H 2001/1283 (20130101)

Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General
F41H 5/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180926 Rastegar et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
APPLICANT(S) Omnitek Partners LLC (Ronkonkoma, New York)
ASSIGNEE(S) Omnitek Partners LLC (Ronkonkoma, New York)
INVENTOR(S) Jahangir S Rastegar (Stony Brook, New York);  Jacques Fischer (Sound Beach, New York)
ABSTRACT A munition including: a control surface actuation device including: an actuator having two or more pistons, each of the pistons being movable between an extended and retracted position, the retracted position resulting from an activation of each of the two or more pistons; and a movable rack having a pocket corresponding to each of the two or more pistons, each pocket being engageable with a corresponding portion of each of the two or more pistons, a distance between the pockets being different than a distance between the portions of the two or more pistons, such that activation of the portion into the corresponding pocket sequentially translates the rack; and a control surface operatively connected to the rack such that translation of the rack rotates the control surface.
FILED Tuesday, August 25, 2020
APPL NO 17/002623
CURRENT CPC
Explosive Charges, e.g for Blasting, Fireworks, Ammunition
F42B 10/18 (20130101)
F42B 10/64 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181172 Ensor et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) Research Triangle Institute (Research Triangle Park, North Carolina)
ASSIGNEE(S)
INVENTOR(S) David S. Ensor (Chapel Hill, North Carolina);  Li Han (Research Triangle Park, North Carolina)
ABSTRACT A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured, and a membrane encasing the fibers and having a thickness ranging from 50 μm to 5.0 mm. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance.
FILED Friday, September 25, 2020
APPL NO 17/032614
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/127 (20130101)
G01N 27/227 (20130101)
G01N 33/0047 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181181 Liu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Xuedong Liu (Niwot, Colorado);  Douglas A. Chapnick (Boulder, Colorado);  William Old (Boulder, Colorado);  Tristan D. Mcclure-Begley (Falls Church, Virginia);  Eric Bunker (Derwood, Maryland)
ABSTRACT Provided are FRET-based biosensor constructs, and multiplexed platforms or arrays of these biosensor constructs useful for screening candidate drug molecules for efficacy and/or specificity of drug activity. Optionally the biosensor constructs may be located on an inner membrane within a cell or engineered to be located on the cell's surface. The cells or cell lines displaying the biosensors on a cell surface may be arranged as an array of cells for high throughput evaluation of the efficacy and/or specificity of drug candidates, such as a library of candidate drug compounds.
FILED Friday, December 14, 2018
APPL NO 16/954100
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/64 (20130101)
G01N 33/5008 (20130101) Original (OR) Class
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181380 WONG et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Science Foundation (NSF)
APPLICANT(S) THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Tak-Sing WONG (University Park, Pennsylvania);  Shikuan YANG (University Park, Pennsylvania);  Nan SUN (University Park, Pennsylvania);  Birgitt BOSCHITSCH (University Park, Pennsylvania)
ABSTRACT Synthetic brochosomes can be prepared by disposing a monolayer of first polymer microspheres on a substrate and forming a layer of metal on the monolayer of the first polymer microspheres. A monolayer of second polymer microspheres is then disposed on the layer of metal to form a template. The second polymer microspheres are smaller than the first polymer microspheres. A brochosome material is then electrodeposited on the template. The brochosome material is selected from the group consisting of a metal, a metal oxide, a polymer or a hybrid thereof. The first polymer microspheres and the second polymer microspheres are then removed to form a coating of synthetic brochosomes of the brochosome material on the substrate.
FILED Monday, January 11, 2021
APPL NO 17/145749
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 9/24 (20130101)

Alloys
C22C 5/02 (20130101)
C22C 5/06 (20130101)

Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor
C25D 1/003 (20130101)
C25D 1/006 (20130101)
C25D 3/48 (20130101)
C25D 5/02 (20130101)
C25D 7/00 (20130101)
C25D 7/006 (20130101)
C25D 9/06 (20130101)
C25D 13/12 (20130101)

Optical Elements, Systems, or Apparatus
G02B 1/116 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181381 LEO et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Sin-Yen LEO (Gainesville, Florida);  Peng JIANG (Gainesville, Florida);  Zhuxiao GU (Gainesville, Florida)
ABSTRACT Described herein are antireflective layers, methods for forming antireflective layers, and structures including antireflective layers. Methods are included for forming a durable antireflective layer on the surface of a substrate, wherein the substrate has a complex three-dimensional shape, wherein the durable antireflective layer comprises a uniform monolayer of silica nanoparticles interconnected by SiO2, a uniform monolayer of silica nanoparticles bonded to the surface of the substrate, or a combination thereof.
FILED Wednesday, December 19, 2018
APPL NO 16/764735
CURRENT CPC
Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials
C03C 17/004 (20130101)
C03C 17/005 (20130101)
C03C 17/25 (20130101)
C03C 2217/213 (20130101)
C03C 2217/732 (20130101)
C03C 2218/32 (20130101)
C03C 2218/111 (20130101)
C03C 2218/115 (20130101)

Optical Elements, Systems, or Apparatus
G02B 1/12 (20130101)
G02B 1/118 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181542 Currie et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
Department of the Navy (DON)
Naval Research Laboratory (NRL)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Marc Currie (Washington, District of Columbia);  Virginia D. Wheeler (Alexandria, Virginia);  Guy Beadie (Falls Church, Virginia)
ABSTRACT A tunable spectral filter comprising a phase change material is incorporated into a multilayered dielectric structure. The dielectric permittivity, and thus the filter properties, of the structure can be modified by producing a change in the phase change material, e.g., causing a metal-insulator transition. By controllably causing such a change in the dielectric permittivity of the phase change material, the spectral transmittance and reflectance of the structure, and thus its filter properties, can be modified to provide a predetermined transmittance or reflectance of electromagnetic radiation incident on the structure. In preferred embodiments, the phase change material layer is a vanadium dioxide (VO2) film formed by atomic layer deposition (ALD).
FILED Friday, December 13, 2019
APPL NO 16/713032
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/0102 (20130101)
G02F 1/0147 (20130101) Original (OR) Class
G02F 2203/055 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181553 Idehenre et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Secretary of the Air Force (SECAF)
APPLICANT(S) Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S) Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S) Ighodalo U. Idehenre (Tipp City, Ohio);  Dean R. Evans (Beavercreek, Ohio)
ABSTRACT A transparent device for use in optical applications, and methods for using and manufacturing the device are disclosed. The device generally requires several layers, including (i) a first layer comprising a transparent conductive oxide (such as indium tin oxide (ITO)), (ii) a second layer comprising a transparent semiconductor (e.g., a pn-heterojunction or a pn-homojunction), the second layer having a surface facing the first layer, (iii) a third layer comprising a liquid crystal (such as E7), the third layer having a surface facing the second layer, and (iv) a fourth layer comprising either a second transparent conductive oxide or a second transparent semiconductor, the fourth layer having a surface facing the third layer. When light illuminates a surface of the transparent metal oxide pn-heterojunction or transparent metal oxide pn-homojunction, it induces photoconductivity, modifying the surface charges.
FILED Wednesday, December 16, 2020
APPL NO 17/123157
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/1354 (20130101) Original (OR) Class
G02F 1/1357 (20210101)
G02F 1/133784 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181673 Ozcan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Office of the Director (NIHOD)
National Science Foundation (NSF)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Aydogan Ozcan (Los Angeles, California);  Alon Grinbaum (Durham, North Carolina);  Yibo Zhang (Los Angeles, California);  Alborz Feizi (Chino, California);  Wei Luo (Los Angeles, California)
ABSTRACT A method for lens-free imaging of a sample or objects within the sample uses multi-height iterative phase retrieval and rotational field transformations to perform wide FOV imaging of pathology samples with clinically comparable image quality to a benchtop lens-based microscope. The solution of the transport-of-intensity (TIE) equation is used as an initial guess in the phase recovery process to speed the image recovery process. The holographically reconstructed image can be digitally focused at any depth within the object FOV (after image capture) without the need for any focus adjustment, and is also digitally corrected for artifacts arising from uncontrolled tilting and height variations between the sample and sensor planes. In an alternative embodiment, a synthetic aperture approach is used with multi-angle iterative phase retrieval to perform wide FOV imaging of pathology samples and increase the effective numerical aperture of the image.
FILED Thursday, November 19, 2020
APPL NO 16/952492
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1429 (20130101)
G01N 15/1434 (20130101)
G01N 15/1475 (20130101)
G01N 2015/1006 (20130101)

Holographic Processes or Apparatus
G03H 1/0005 (20130101) Original (OR) Class
G03H 1/0443 (20130101)
G03H 1/0866 (20130101)
G03H 1/0891 (20130101)

Pictorial Communication, e.g Television
H04N 5/2256 (20130101)
H04N 5/23238 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181991 Brewer
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Tony M. Brewer (Plano, Texas)
ABSTRACT A memory controller circuit is disclosed which is coupleable to a first memory circuit, such as DRAM, and includes: a first memory control circuit to read from or write to the first memory circuit; a second memory circuit, such as SRAM; a second memory control circuit adapted to read from the second memory circuit in response to a read request when the requested data is stored in the second memory circuit, and otherwise to transfer the read request to the first memory control circuit; predetermined atomic operations circuitry; and programmable atomic operations circuitry adapted to perform at least one programmable atomic operation. The second memory control circuit also transfers a received programmable atomic operation request to the programmable atomic operations circuitry and sets a hazard bit for a cache line of the second memory circuit.
FILED Monday, February 08, 2021
APPL NO 17/170001
CURRENT CPC
Electric Digital Data Processing
G06F 3/0604 (20130101)
G06F 3/0659 (20130101) Original (OR) Class
G06F 3/0683 (20130101)
G06F 12/0875 (20130101)
G06F 2212/452 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182244 Kaddoura
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
APPLICANT(S) ARCHITECTURE TECHNOLOGY CORPORATION (Eden Prairie, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Maher N. Kaddoura (Maple Grove, Minnesota)
ABSTRACT Software generates a ledger fragment by generating a first block having first data in a first record data field, a nonce value in a first previous block pointer field, and a first hash in a first hash field. Generating the ledger fragment also includes generating a second block having second data in a second record data field, the first hash in a second previous block pointer field, and a second hash in a second hash field. The ledger fragment is appended to a main ledger with a linking block. The linking block is positioned between the first block of the ledger fragment and an end block of the main ledger. The linking block includes a third hash from the end block in a fourth previous block pointer field and the nonce value in a fourth hash field. The linking block is signed by a plurality of voting peers.
FILED Wednesday, September 30, 2020
APPL NO 17/039323
CURRENT CPC
Electric Digital Data Processing
G06F 16/1834 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182387 Zhu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) Ziyun Zhu (Jersey City, New Jersey);  Xiaokui Shu (Ossining, New York);  Dhilung Hang Kirat (White Plains, New York);  Jiyong Jang (White Plains, New York);  Marc Philippe Stoecklin (White Plains, New York)
ABSTRACT A method to detect anomalous behavior in an execution environment. A set of system events captured from a monitored computing system are received. Using the received system events, a model is then trained using machine learning. The model is trained to automatically extract one or more features for the received set of system events, wherein a system event feature is determined by a semantic analysis and represents a semantic relationship between or among a grouping of system events that are observed to co-occur in an observation sample. An observation sample is associated with an operating scenario that has occurred in the execution environment. Once trained, and using the features, the model is used to detect anomalous behavior. As an optimization, prior to training, the set of system events are pre-processed into a reduced set of system events. The modeler may comprise a component of a malware detection system.
FILED Thursday, December 12, 2019
APPL NO 16/711688
CURRENT CPC
Electric Digital Data Processing
G06F 21/52 (20130101)
G06F 21/554 (20130101) Original (OR) Class

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6215 (20130101)
G06K 9/6232 (20130101)

Computer Systems Based on Specific Computational Models
G06N 7/005 (20130101)
G06N 20/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210183469 Lu et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Universidade Católica de Brasília (Aguas Claras, Brazil)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Universidade Católica de Brasília (Aguas Claras, Brazil)
INVENTOR(S) Timothy Kuan-Ta Lu (Cambridge, Massachusetts);  Cesar De la Fuente Nunez (Somerville, Massachusetts);  William Porto (Brasília-DF, Brazil);  Octavio Franco (Brasília-DF, Brazil)
ABSTRACT Disclosed herein are methods of designing peptides having at least one property of interest, such as α-helical propensity, higher net charge, hydrophobicity, and/or hydrophobic moment. Also disclosed herein are novel artificially evolved peptides (e.g., antimicrobial peptides), which may be designed according to the methods described herein, and methods of use thereof.
FILED Tuesday, March 12, 2019
APPL NO 16/299641
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Peptides
C07K 14/001 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 35/10 (20190201) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210183808 Esler et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Air Force Research Laboratory (AFRL)
United States Air Force (USAF)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) David Richard Esler (Gloversville, New York);  Nancy Cecelia Stoffel (Niskayuna, New York)
ABSTRACT A sensor assembly includes a die substrate and a metalized layer formed on the die substrate. The metalized layer is formed of a first metal material and includes a bonding pad to facilitate electrically coupling the sensor assembly to a sensor system. A re-metalized bump is formed on the bonding pad of a second metal material and is electrically coupled to the metalized layer. An adhesive is applied to the re-metalized bump and facilitates mechanically coupling the sensor assembly to the sensor system.
FILED Friday, December 13, 2019
APPL NO 16/713437
CURRENT CPC
Microstructural Devices or Systems, e.g Micromechanical Devices
B81B 7/0006 (20130101)
B81B 2207/098 (20130101)

Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems
B81C 1/00301 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 24/05 (20130101)
H01L 24/08 (20130101)
H01L 24/11 (20130101)
H01L 24/13 (20130101)
H01L 24/32 (20130101)
H01L 24/73 (20130101) Original (OR) Class
H01L 24/92 (20130101)
H01L 41/0475 (20130101)
H01L 2224/05124 (20130101)
H01L 2224/05686 (20130101)
H01L 2224/9211 (20130101)
H01L 2224/13124 (20130101)
H01L 2224/13144 (20130101)
H01L 2224/13147 (20130101)
H01L 2224/13164 (20130101)
H01L 2224/13169 (20130101)
H01L 2224/16157 (20130101)
H01L 2224/16227 (20130101)
H01L 2224/32157 (20130101)
H01L 2224/32227 (20130101)
H01L 2224/73104 (20130101)
H01L 2224/73204 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184098 TAYLOR et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
Space and Naval Warfare Systems (SPAWAR)
APPLICANT(S) THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (SAN DIEGO, California)
ASSIGNEE(S) THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (SAN DIEGO, California)
INVENTOR(S) BENJAMIN J. TAYLOR (ESCONDIDO, California);  TERESA H. EMERY (SAN DIEGO, California)
ABSTRACT A method includes providing a film of a high-temperature superconductor compound on a flexible substrate, where a portion of the film has a first oxygen state, and exposing a portion of the film to a focused ion beam to create a structure within the film. The structure may result from the portion of the film being partially or completely removed. The structure may be a trench along the length or width of the film. The method may include annealing the exposed portion of the film to a second oxygen state. The oxygen content of the second oxygen state may be greater or less than the oxygen content of the first oxygen state.
FILED Monday, December 16, 2019
APPL NO 16/716179
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 39/249 (20130101)
H01L 39/2454 (20130101) Original (OR) Class
H01L 39/2467 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184209 LIU et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Secretary of the Army (SECARMY)
APPLICANT(S) HYDRO-QUEBEC (Montreal, Canada);  Government of the United States of America, as Represented by the Secretary of the Army (Aberdeen Proving Ground, Maryland)
ASSIGNEE(S)
INVENTOR(S) DONGQIANG LIU (Longueuil, Canada);  AMELIE FORAND (Boucherville, Canada);  CHISU KIM (Longueuil, Canada);  KARIM ZAGHIB (Longueuil, Canada);  JAN L. ALLEN (Aberdeen Proving Ground, Maryland);  SAMUEL A. DELP, III (Aberdeen Proving Ground, Maryland);  RICHARD T. JOW (Aberdeen Proving Ground, Maryland);  MYUNGHUN CHO (Brossard, Canada);  ABDELBAST GUERFI (Brossard, Canada)
ABSTRACT The disclosure provides a coated positive electrode active material particle including an active material having the general chemical formula AxMyEz(XO4)q, wherein A is an alkali metal or an alkaline earth metal, M includes cobalt, E is a non-electrochemically active metal, a boron group element, or silicon or any alloys or combinations thereof, X is phosphorus or sulfur or a combination thereof, 0<x≤1, y>0, z≥0, q>0, and the relative values of x, y, z, and q are such that the general chemical formula is charge balanced. The disclosure provides a method of attritor-mixing the active material. The disclosure provides an alkali metal or alkaline earth metal rechargeable battery including an electrolyte including an ionic liquid and an alkali metal salt or alkaline earth metal salt. The battery includes a pressure application system that applies pressure to at least a portion of the electrode surfaces contacting the electrolyte.
FILED Wednesday, February 24, 2021
APPL NO 17/184447
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/58 (20130101)
H01M 4/366 (20130101) Original (OR) Class
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184263 LIU et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Secretary of the Army (SECARMY)
APPLICANT(S) HYDRO-QUEBEC (Montreal, Canada);  Government of the United States of America, as Represented by the Secretary of the Army (Aberdeen Proving Ground, Maryland)
ASSIGNEE(S)
INVENTOR(S) DONGQIANG LIU (Longueuil, Canada);  AMELIE FORAND (Boucherville, Canada);  CHISU KIM (Longueuil, Canada);  KARIM ZAGHIB (Longueuil, Canada);  JAN L. ALLEN (Aberdeen Proving Ground, Maryland);  SAMUEL A. DELP, III (Aberdeen Proving Ground, Maryland);  RICHARD T. JOW (Aberdeen Proving Ground, Maryland)
ABSTRACT The disclosure provides an alkali metal or alkaline earth metal rechargeable battery including an electrolyte including an ionic liquid and an alkali metal salt or alkaline earth metal salt. The battery also includes a negative electrode including a surface that contacts the electrolyte. The negative electrode also includes a negative electrode active material. The battery further includes a positive electrode including a surface that contacts the electrolyte. The positive electrode also includes a positive electrode active material. The battery also includes an electronically insulative separator between the positive electrode and the negative electrode and a casing surrounding the electrolyte, electrodes, and separator. The battery additionally includes a pressure application system that applies pressure to at least a portion of the electrode surfaces contacting the electrolyte.
FILED Wednesday, February 24, 2021
APPL NO 17/184436
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/58 (20130101)
H01M 4/136 (20130101)
H01M 4/139 (20130101)
H01M 10/44 (20130101)
H01M 10/0525 (20130101)
H01M 10/0567 (20130101)
H01M 10/0568 (20130101) Original (OR) Class
H01M 10/0569 (20130101)
H01M 2004/027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20210177756 NOY et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
National Science Foundation (NSF)
APPLICANT(S) Nga Thuy HO (, None);  Lawrence Livermore National Security, LLC (Livermore, California);  Max-Planck-Gesellschaft Zur Foerderung Dur Wissenschaften E.V. (Munich, Germany)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California);  Max-Planck-Gesellschaft Zur Foerderung Dur Wissenschaften E.V. (Munich, Germany)
INVENTOR(S) Aleksandr NOY (Livermore, California);  Nga Thuy HO (Oakland, California);  Gerhard HUMMER (Munchen, Germany);  Marc SIGGEL (Munchen, Germany)
ABSTRACT Disclosed herein is an engineered lipid-based vesicle optionally used for delivery of one or more payloads. The vesicle comprises a nanotube dimer or complex embedded with a lipid bilayer of the lipid-based vesicle. Also described herein are compositions, e.g., pharmaceutical compositions, and kits comprising the engineered lipid-based vesicle. In additional embodiments, further described herein are use of the engineered lipid-based vesicle for treating a disease or condition, for delivery to a target, or for labeling of a cell.
FILED Monday, December 14, 2020
APPL NO 17/121578
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/1271 (20130101) Original (OR) Class
A61K 31/65 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177769 HAYES et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
National Science Foundation (NSF)
APPLICANT(S) THE PENN STATE RESEARCH FOUNDATION (UNIVERSITY PARK, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Daniel J HAYES (State College, Pennsylvania);  Mohammad ABU-LABAN (State College, Pennsylvania)
ABSTRACT In one aspect, compositions are described herein. A composition described herein comprises a nanoparticle, a therapeutic species, and a linker joining the nanoparticle to the therapeutic species. The linker joining the nanoparticle to the therapeutic species comprises a Diels-Alder cyclo-addition reaction product. Additionally, in some embodiments, the nanoparticle is a magnetic nanoparticle.
FILED Friday, July 13, 2018
APPL NO 16/630806
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5094 (20130101) Original (OR) Class
A61K 9/5115 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177770 SAILOR et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Eye Institute (NEI)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) SPINNAKER BIOSCIENCES, INC. (Solana Beach, California);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S) SPINNAKER BIOSCIENCES, INC. (Solana Beach, California);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S) Michael J. SAILOR (La Jolla, California);  Jinyoung KANG (La Jolla, California);  Jinmyoung JOO (Seoul, South Korea);  Emily ANGLIN (San Marcos, California);  Ester KWON (Cambridge, Massachusetts);  Matthew SKALAK (Boston, Massachusetts);  Sangeeta BHATIA (Lexington, Massachusetts)
ABSTRACT Compositions useful in the controlled delivery of therapeutic agents and their methods of preparation and use are provided. The compositions comprise an optionally oxidized porous silicon core, a layer on the surface of the porous silicon core that comprises a metal silicate, and a therapeutic agent. The compositions optionally further comprise one or more targeting agents and/or cell-penetrating agents to enable the particles to target and enter cells or tissues of interest in a treated subject.
FILED Friday, April 14, 2017
APPL NO 16/093131
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5115 (20130101) Original (OR) Class
A61K 9/5192 (20130101)
A61K 38/17 (20130101)
A61K 38/162 (20130101)
A61K 49/0004 (20130101)
A61K 49/0013 (20130101)
A61K 49/0093 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)
C12N 2310/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177974 Taylor et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) NORTH CAROLINA CENTRAL UNIVERSITY (DURHAM, North Carolina)
ASSIGNEE(S) NORTH CAROLINA CENTRAL UNIVERSITY (Durham, North Carolina)
INVENTOR(S) Darlene K. Taylor (Burlington, North Carolina);  Melony A. Ochieng (Durham, North Carolina)
ABSTRACT A delivery system using materials that form a liquogel or nanocarrier are described. The delivery system comprises hyperbranched polyglycerols (HPGs). The delivery system can include a drug or therapeutic agent and this system can be used to administer the drug or therapeutic agent locally. The delivery system provides for controlled release of the drug or therapeutic agent.
FILED Friday, October 16, 2020
APPL NO 17/072804
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 9/0024 (20130101)
A61K 31/565 (20130101)
A61K 31/4745 (20130101)
A61K 47/34 (20130101) Original (OR) Class
A61K 47/59 (20170801)
A61K 47/551 (20170801)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 83/006 (20130101)

Compositions of Macromolecular Compounds
C08L 101/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177982 Ahmad et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) DNALite Therapeutics, Inc. (San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Mubhij Ahmad (San Francisco, California);  Timothy Paul Day (San Francisco, California);  Cassandra Callmann (San Francisco, California);  Xixi Zhu (San Francisco, California);  Ismail Hafez (San Francisco, California)
ABSTRACT Provided are compositions including delivery vehicles with at least one mucus-penetrating property and mucus-penetrating peptides. Also disclosed are such compositions including a cargo and methods of making and using the same.
FILED Friday, November 13, 2020
APPL NO 17/098053
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/64 (20170801) Original (OR) Class
A61K 47/6929 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178340 Knauss et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) Daniel M. Knauss (Golden, Colorado);  Derek J. Strasser (Parker, Colorado)
ASSIGNEE(S)
INVENTOR(S) Daniel M. Knauss (Golden, Colorado);  Derek J. Strasser (Parker, Colorado)
ABSTRACT The invention relates to membranes, monomers and polymers. The monomers can form polymers, which can be used for membranes. The membranes can be used in alkaline fuel cells, for water purification, for electrolysis, for flow batteries, and for anti-bacterial membranes and materials, as well as membrane electrode assemblies for fuel cells. In addition to the membranes, polymers and monomers and methods of using the membranes, the present invention also relates to methods of making the membranes, monomers and polymers.
FILED Friday, February 19, 2021
APPL NO 17/180629
CURRENT CPC
Separation
B01D 67/0009 (20130101)
B01D 67/0013 (20130101)
B01D 67/0093 (20130101)
B01D 71/62 (20130101) Original (OR) Class
B01D 71/76 (20130101)
B01D 71/80 (20130101)
B01D 71/82 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 75/20 (20130101)
C08G 75/045 (20130101)
C08G 81/024 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/2262 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/38 (20130101)

Compositions of Macromolecular Compounds
C08L 53/00 (20130101)
C08L 81/02 (20130101)
C08L 81/06 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 8/1032 (20130101)
H01M 8/1067 (20130101)
H01M 8/1072 (20130101)
H01M 8/1081 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178436 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Wareham, Massachusetts)
ASSIGNEE(S) Loci Controls, Inc. (Wareham, Massachusetts)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Joseph G. Michels (New York, New York);  Melinda Sims (Seattle, Washington)
ABSTRACT A control system for controlling extraction of landfill gas from a landfill via a gas extraction system comprising well piping, the landfill gas having a first temperature when extracted, the control system comprising: a gas composition chamber coupled to the well piping and comprising at least one sensor configured to measure one or more characteristics of a landfill gas sample in the gas composition chamber; a temperature control mechanism configured to heat the landfill gas sample in the gas composition chamber to a second temperature at least a threshold amount greater than the first temperature; and a controller configured to control the at least one sensor to measure the one or more characteristics of the landfill gas sample in the gas composition chamber when a temperature of the landfill gas sample in the gas composition chamber is at least the threshold amount greater than the first temperature.
FILED Thursday, February 04, 2021
APPL NO 17/167539
CURRENT CPC
Disposal of Solid Waste
B09B 1/00 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/0016 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178636 LeDuc et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Army (DOA)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania);  University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S) Philip R. LeDuc (Wexford, Pennsylvania);  O. Burak Ozdoganlar (Sewickley, Pennsylvania);  Mary E. Wilson (Baltimore, Maryland);  Emrullah Korkmaz (Pittsburgh, Pennsylvania);  Yadong Wang (Pittsburgh, Pennsylvania);  Donna Beer-Stolz (Pittsburgh, Pennsylvania)
ABSTRACT The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a shape that mimics a biological network. Cellular material can be seeded around the template or a space created by the template and grown into an engineered tissue-construct.
FILED Monday, February 08, 2021
APPL NO 17/170706
CURRENT CPC
Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics
B29B 11/14 (20130101) Original (OR) Class

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 33/3842 (20130101)

Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles
B29L 2031/7534 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178738 HEMNANI et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The George Washington University (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Rohit Anil HEMNANI (Washington, District of Columbia);  Volker J. SORGER (Alexandria, Virginia)
ABSTRACT Precision and chip contamination-free placement of two-dimensional (2D) material and van der Waals (VDW) layered materials accelerates both the study of fundamental properties and novel device functionality. The system transfers 2D materials utilizing a combination of a narrow transfer-stamper and viscoelastic and optically transparent film. Precise placement of individual 2D materials results in vanishing cross-contamination to the substrate. The 2D printer results in an aerial cross-contamination improvement of two to three orders of magnitude relative to state-of-the-art transfer methods from a source of average area sub um{circumflex over ( )}2. The transfer-stamper does not physically harm any micro/nanostructures preexisting on the target substrates receiving the 2D material such as, nanoelectronics, waveguides or micro-ring resonators. Such accurate and substrate-benign transfer method for 2D and VDW layered materials provides rapid device prototyping due to its high time-reduction, accuracy, and contamination-free process.
FILED Monday, February 15, 2021
APPL NO 17/176142
CURRENT CPC
Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 37/025 (20130101) Original (OR) Class
B32B 41/00 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 10/00 (20130101)
B82Y 40/00 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/762 (20130101)
H01L 29/778 (20130101)
H01L 29/1606 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179553 TOSCANO et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) John Pasquale TOSCANO (Baltimore, Maryland);  Vinayak S. KHODADE (Baltimore, Maryland)
ABSTRACT A hydropersulfide precursor compound having the formula (I): formula (I) as defined in the specification. A process for preparing the hydropersulfide precursor, and a method of using the precursor to generate hydropersulfide are also described.
FILED Friday, August 30, 2019
APPL NO 17/268616
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 335/30 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179588 Hollis et al.
FUNDED BY
Department of Education (ED)
National Science Foundation (NSF)
APPLICANT(S) Mississippi State University (Starkville, Mississippi)
ASSIGNEE(S)
INVENTOR(S) Thedford Keith Hollis (Starkville, Mississippi);  Charles Edwin Webster (Starkville, Mississippi)
ABSTRACT Provided herein are unsymmetrical bis(azolium) salts, unsymmetrical CCC—NHC metal complexes, and methods of forming the same. The unsymmetrical bis(azolium) salts include a central aryl ring that is substituted with two heterocyclic rings in an ortho, meta, or para fashion. The unsymmetrical CCC—NHC metal complexes include metalated unsymmetrical bis(azolium) salts. The method of forming the unsymmetrical CCC—NHC metal complexes includes reacting a dihalogenated benzene with a first azole to form a mono(azole)benzene, reacting the mono(azole)benzene with a second azole to form an unsymmetrical bis(azole)benzene, alkylating the unsymmetrical bis(azole)benzene to form an unsymmetrical bis(azolium) salt, and metalating the unsymmetrical bis(azolium) salt to form the unsymmetrical CCC—NHC metal complex. Also provided are a bis-ligated CCC—NHC metal complex and an unsymmetrical bimetallic complex.
FILED Monday, February 22, 2021
APPL NO 17/182199
CURRENT CPC
Heterocyclic Compounds
C07D 403/10 (20130101) Original (OR) Class

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 15/02 (20130101)
C07F 15/0086 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179939 Stokes et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) The Regents Of The University Of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Benjamin J. Stokes (Merced, California);  Amir Keshavarz (Merced, California)
ABSTRACT Organic ligands and methods for preparing a variety of organic ligands are provided. The subject methods provide for the preparation of organic ligands in high yield and purity for use as ligands for attachment to nanoparticles to enable the formation of three dimensional nanocapsules of stably associated organic ligand-functionalized nanoparticles. Compositions that include these nanocapsules, as well as methods of making the nanocapsules are also provided.
FILED Tuesday, October 30, 2018
APPL NO 16/758685
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Acyclic or Carbocyclic Compounds
C07C 213/08 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/565 (20130101)
C09K 11/883 (20130101)
C09K 19/12 (20130101) Original (OR) Class
C09K 19/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180028 Melvin et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana)
ASSIGNEE(S)
INVENTOR(S) Adam Melvin (Baton Rouge, Louisiana);  John Pojman (Baton Rouge, Louisiana);  Anowar Khan (Baton Rouge, Louisiana)
ABSTRACT Provided are thiol-acrylate hydrogels and tunable cell culture materials including thiol-acrylate hydrogels, and methods of making thereof. Also provided are systems for forming three-dimensional cell culture scaffolds including the materials, and methods of culturing cells, including cancer cells, using thiol-acrylate hydrogels and tunable cell culture materials. The materials herein can be used in microfluidic droplet-generating devices.
FILED Wednesday, December 09, 2020
APPL NO 17/116289
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/16 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0062 (20130101)
C12N 5/0693 (20130101) Original (OR) Class
C12N 2500/05 (20130101)
C12N 2500/34 (20130101)
C12N 2513/00 (20130101)
C12N 2533/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180076 QI
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Organismal Systems (IOS)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) YIPING QI (POTOMAC, Maryland)
ABSTRACT Compositions and methods for modifying genomic DNA sequences of a plant cell are provided. The methods produce double stranded breaks at target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. The compositions comprise DNA constructs comprising nucleotide sequences that encode a Cas12b protein. The DNA constructs can be used to direct the modification of genomic DNA at a target site. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.
FILED Thursday, December 17, 2020
APPL NO 17/247582
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/8213 (20130101) Original (OR) Class
C12N 15/8216 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180937 Jin et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Camegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Haojian Jin (Pittsburgh, Pennsylvania);  Jingxian Wang (Pittsburgh, Pennsylvania);  Swarun Kumar Suresh Kumar (Pittsburgh, Pennsylvania);  Jason I. Hong (Pittsburgh, Pennsylvania)
ABSTRACT A method, system, and computer program product is provided for tracking the shape of a surface. The method includes generating a first plurality of surface models based on the surface, each surface model associated with surface parameter values and representing a different shape, determining an estimated position of the plurality of RF transponders on each surface model of the first plurality of surface models, communicating at least one activation signal to the plurality of RF transponders arranged on the surface, the surface comprising an unknown shape, receiving a plurality of response signals from at least a subset of the plurality of RF transponders, determining radio environment parameters for each surface model of the first plurality of surface models, and determining at least one selected surface model of the first plurality of surface models.
FILED Wednesday, April 24, 2019
APPL NO 17/050010
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 7/16 (20130101)
G01B 7/287 (20130101) Original (OR) Class

Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 13/75 (20130101)
G01S 13/89 (20130101)
G01S 13/878 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181188 Carter et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
Office of the Director (NIHOD)
National Library of Medicine (NLM)
National Resource for Network Biology (NRNB)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Hannah Carter (San Diego, California);  Rachel Marty (San Diego, California);  Maurizio Zanetti (La Jolla, California);  Wesley Kurt Thompson (Arcadia, California);  Joan Font-Burgada (San Diego, California)
ABSTRACT The present disclosure provides methods of determining the risk of a subject having or developing a cancer based on the affinity of the subjects MHC-II alleles for oncogenic mutations, methods for improving cancer diagnosis, and kits comprising agents that detect the oncogenic mutations in a subject.
FILED Friday, August 23, 2019
APPL NO 17/270653
CURRENT CPC
Peptides
C07K 7/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5308 (20130101) Original (OR) Class
G01N 2333/70539 (20130101)
G01N 2800/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181276 Mandal et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Soumyajit Mandal (Shaker Heights, Ohio);  David Ariando (Cleveland, Ohio);  Mason Greer (Cleveland Heights, Ohio);  Cheng Chen (Cleveland, Ohio)
ABSTRACT An example multi-channel magnetic resonance (MR) system is described. The system includes a plurality of radio frequency (RF) coils and a plurality of spectrometer transceiver channels. Each of the channels including a spectrometer coupled a respective set of the RF coils. The spectrometer is configured to transmit RF signals to excite respective RF coils and to receive MR sensor signals from the excited respective RF coils responsive to excitation thereof. The spectrometer is configured to perform MR spectrometry to provide MR measurement data based on the received MR sensor signals for the respective channel. A synchronization module is coupled to the spectrometer of the respective channel. The synchronization module is configured to synchronize the spectrometer of the respective channel with spectrometers in other channels via a communication link.
FILED Thursday, December 17, 2020
APPL NO 17/125563
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/543 (20130101)
G01R 33/3607 (20130101)
G01R 33/3621 (20130101)
G01R 33/3635 (20130101)
G01R 33/5608 (20130101)
G01R 33/34092 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181380 WONG et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Science Foundation (NSF)
APPLICANT(S) THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Tak-Sing WONG (University Park, Pennsylvania);  Shikuan YANG (University Park, Pennsylvania);  Nan SUN (University Park, Pennsylvania);  Birgitt BOSCHITSCH (University Park, Pennsylvania)
ABSTRACT Synthetic brochosomes can be prepared by disposing a monolayer of first polymer microspheres on a substrate and forming a layer of metal on the monolayer of the first polymer microspheres. A monolayer of second polymer microspheres is then disposed on the layer of metal to form a template. The second polymer microspheres are smaller than the first polymer microspheres. A brochosome material is then electrodeposited on the template. The brochosome material is selected from the group consisting of a metal, a metal oxide, a polymer or a hybrid thereof. The first polymer microspheres and the second polymer microspheres are then removed to form a coating of synthetic brochosomes of the brochosome material on the substrate.
FILED Monday, January 11, 2021
APPL NO 17/145749
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 9/24 (20130101)

Alloys
C22C 5/02 (20130101)
C22C 5/06 (20130101)

Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor
C25D 1/003 (20130101)
C25D 1/006 (20130101)
C25D 3/48 (20130101)
C25D 5/02 (20130101)
C25D 7/00 (20130101)
C25D 7/006 (20130101)
C25D 9/06 (20130101)
C25D 13/12 (20130101)

Optical Elements, Systems, or Apparatus
G02B 1/116 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181381 LEO et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Sin-Yen LEO (Gainesville, Florida);  Peng JIANG (Gainesville, Florida);  Zhuxiao GU (Gainesville, Florida)
ABSTRACT Described herein are antireflective layers, methods for forming antireflective layers, and structures including antireflective layers. Methods are included for forming a durable antireflective layer on the surface of a substrate, wherein the substrate has a complex three-dimensional shape, wherein the durable antireflective layer comprises a uniform monolayer of silica nanoparticles interconnected by SiO2, a uniform monolayer of silica nanoparticles bonded to the surface of the substrate, or a combination thereof.
FILED Wednesday, December 19, 2018
APPL NO 16/764735
CURRENT CPC
Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials
C03C 17/004 (20130101)
C03C 17/005 (20130101)
C03C 17/25 (20130101)
C03C 2217/213 (20130101)
C03C 2217/732 (20130101)
C03C 2218/32 (20130101)
C03C 2218/111 (20130101)
C03C 2218/115 (20130101)

Optical Elements, Systems, or Apparatus
G02B 1/12 (20130101)
G02B 1/118 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181673 Ozcan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Office of the Director (NIHOD)
National Science Foundation (NSF)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Aydogan Ozcan (Los Angeles, California);  Alon Grinbaum (Durham, North Carolina);  Yibo Zhang (Los Angeles, California);  Alborz Feizi (Chino, California);  Wei Luo (Los Angeles, California)
ABSTRACT A method for lens-free imaging of a sample or objects within the sample uses multi-height iterative phase retrieval and rotational field transformations to perform wide FOV imaging of pathology samples with clinically comparable image quality to a benchtop lens-based microscope. The solution of the transport-of-intensity (TIE) equation is used as an initial guess in the phase recovery process to speed the image recovery process. The holographically reconstructed image can be digitally focused at any depth within the object FOV (after image capture) without the need for any focus adjustment, and is also digitally corrected for artifacts arising from uncontrolled tilting and height variations between the sample and sensor planes. In an alternative embodiment, a synthetic aperture approach is used with multi-angle iterative phase retrieval to perform wide FOV imaging of pathology samples and increase the effective numerical aperture of the image.
FILED Thursday, November 19, 2020
APPL NO 16/952492
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1429 (20130101)
G01N 15/1434 (20130101)
G01N 15/1475 (20130101)
G01N 2015/1006 (20130101)

Holographic Processes or Apparatus
G03H 1/0005 (20130101) Original (OR) Class
G03H 1/0443 (20130101)
G03H 1/0866 (20130101)
G03H 1/0891 (20130101)

Pictorial Communication, e.g Television
H04N 5/2256 (20130101)
H04N 5/23238 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181855 Yetkin et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Oguz Yetkin (Dallas, Texas);  Joseph D. Sanford (Dallas, Texas);  Dan O. Popa (Louisville, Kentucky);  Lena C. Wallace (Grand Prairie, Texas);  Fahad Mirza (Arlington, Texas);  Roopak Karulkar (Arlington, Texas);  Sumit Kumar Das (Louisville, Kentucky);  Joshua R. Baptist (Louisville, Kentucky);  J. Paul Carpenter (Fort Worth, Texas)
ABSTRACT Systems and methods for manual gesture recognition to control prosthetic devices. Low encumbrance systems utilizing glove-based recognition to control prosthetic devices. Prosthetic control systems and methods are also provided utilizing elements for application on the user's fingernails.
FILED Monday, November 30, 2020
APPL NO 17/106478
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/72 (20130101)
A61F 2002/707 (20130101)

Electric Digital Data Processing
G06F 1/163 (20130101)
G06F 3/014 (20130101)
G06F 3/015 (20130101)
G06F 3/017 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182073 Karageorgos et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Yale University (New Haven, Connecticut)
ASSIGNEE(S) Yale University (New Haven, Connecticut)
INVENTOR(S) Ioannis Karageorgos (New Haven, Connecticut);  Karthik Sriram (New Haven, Connecticut);  Jan Vesely (Hamden, Connecticut);  Rajit Manohar (New Haven, Connecticut);  Abhishek Bhattacharjee (New Haven, Connecticut)
ABSTRACT One aspect of the invention provides a computer processing architecture including: a plurality of processors, each processor configured to: receive a set of data from one or more input channels or from another processor; execute at least one of a plurality of individualized processes on the data; and output the processed data according to an independent clock domain of the processor; a plurality of switches, wherein each switch connects a processor to an input channel of the one or more input channels or to another processor; and a micro-controller configured to: receive the processed data; control the plurality of switches by activating or deactivating each switch; generate a pipeline of processors from activating and deactivating the plurality of switches; and select one or more individualized processes of the plurality of individualized processes that each processor within the pipeline executes.
FILED Tuesday, December 08, 2020
APPL NO 17/115195
CURRENT CPC
Electric Digital Data Processing
G06F 1/10 (20130101)
G06F 3/015 (20130101)
G06F 9/3871 (20130101) Original (OR) Class
G06F 9/4881 (20130101)
G06F 13/4022 (20130101)
G06F 17/142 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182601 FRANK et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Lawrence R. FRANK (San Diego, California);  Vitaly L. GALINSKY (San Diego, California)
ABSTRACT A method for analysis of complex spatio-temporal data within a dynamic system that includes spatial positions and fields, at least a portion of which are interacting, includes determining values of mean field at every spatial position, determining spatio-temporal eigenmodes in spatial-frequency space assuming interacting fields, and determining spatial and temporal interactions between the eigenmodes. The resulting display indicates space/time localization patterns that are indicative of connectivity within the dynamic system.
FILED Sunday, January 31, 2021
APPL NO 17/163481
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/00 (20130101)
A61B 5/055 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/4806 (20130101)
G01R 33/5608 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00536 (20130101)
G06K 9/6214 (20130101) Original (OR) Class
G06K 9/6247 (20130101)
G06K 9/6271 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 2207/10088 (20130101)
G06T 2207/30016 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182683 DAI et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S) The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S) Xiaoliang DAI (Princeton, New Jersey);  Hongxu YIN (Princeton, New Jersey);  Niraj K. JHA (Princeton, New Jersey)
ABSTRACT According to various embodiments, a method for generating one or more optimal neural network architectures is disclosed. The method includes providing an initial seed neural network architecture and utilizing sequential phases to synthesize the neural network until a desired neural network architecture is reached. The phases include a gradient-based growth phase and a magnitude-based pruning phase.
FILED Thursday, October 25, 2018
APPL NO 16/760209
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/04 (20130101)
G06N 3/082 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210183085 Pau et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) Stanley Pau (Tucson, Arizona);  Rongguang Liang (Tucson, Arizona)
ABSTRACT Methods and systems are described that enable three-dimensional (3D) imaging of objects. One example system includes a light source that produces multiple light beams having specific spectral content and polarization states. The system also includes phase masks that modify the intensity or phase of the light, and projection optics that allow simultaneously projection of at least three fringe patterns onto an object having particular phase, polarization and spectral characteristics. The detection system includes a camera that simultaneously receives light associated with the at the fringe patterns upon reflection from the object, and a processing unit coupled to the camera unit that determines one or both of a phase or a depth information associated with the object. The system and associated methods can efficiency produce 2D images of the object and allow determination of characteristics such as surface profile. The disclosed systems and methods can be effectively implemented with moving objects.
FILED Friday, December 07, 2018
APPL NO 16/770793
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 11/25 (20130101)

Image Data Processing or Generation, in General
G06T 7/521 (20170101) Original (OR) Class
G06T 17/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210183473 PROCYON ESTRADA-PIEDRA et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) STC.UNM. (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Trilce PROCYON ESTRADA-PIEDRA (Albuquerque, New Mexico);  Jeremy BENSON (Albuquerque, New Mexico);  Hector CARRILLO-CABADA (Albuquerque, New Mexico);  Ewa DEELMAN (Albuquerque, New Mexico);  Michela TAUFER (Newark, Delaware)
ABSTRACT The present invention is directed to a system and methods of predicting protein function through a process of encoding protein structural information into a computer readable format and the use of a convolutional neural network designed to recognize such encoded format.
FILED Thursday, November 08, 2018
APPL NO 16/761663
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 15/20 (20190201)
G16B 15/30 (20190201)
G16B 40/00 (20190201)
G16B 45/00 (20190201) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210183555 Hartman et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Science Foundation (NSF)
APPLICANT(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S) Seth Hartman (Belton, Missouri);  Erik Timpson (Lee's Summit, Missouri)
ABSTRACT An electromagnetic propulsion system is provided. The system comprises first and second pluralities of stator coils wound about first and second axes, a plurality of support structures, first and second couplers that surround portions of the first and second pluralities of stator coils, and first and second pluralities of sets of rotor coils wound about axes that are parallel to the first and second axes. The stator coils are configured to receive electric current through an outside controller selecting appropriately coupled stator sections or through a sliding electrical contact system or bearing system to induce at least a first magnetic field. The plurality of support structures supports the first and second plurality of stator coils. The first and second couplers include notches and are oriented so that their notches pass over the plurality of support structures when the couplers move along the stator coils. The couplers may have an adjustable segment to close the notch. The sets of rotor coils are equidistantly attached to the couplers and are configured to receive electric current to induce magnetic fields that interact with the magnetic fields of the stator coils so that magnetic forces are applied to the plurality of rotor coils, thereby propelling the couplers along the stator coils.
FILED Thursday, December 12, 2019
APPL NO 16/711776
CURRENT CPC
Weapons for Projecting Missiles Without Use of Explosive or Combustible Propellant Charge; Weapons Not Otherwise Provided for
F41B 6/006 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 7/17 (20130101)
H01F 7/064 (20130101) Original (OR) Class

Dynamo-electric Machines
H02K 1/2786 (20130101)
H02K 5/167 (20130101)
H02K 7/09 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184203 ZHOU et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina)
ASSIGNEE(S)
INVENTOR(S) XIAO-DONG ZHOU (IRMO, South Carolina);  KUBER MISHRA (COLUMBIA, South Carolina);  FU-SHENG KE (WUHAN, China PRC)
ABSTRACT Methods are provided for forming an electrode. The method can comprise thermally reducing GeO2 powders at a reducing temperature of 300° C. to 600° C. to produce Ge particles; mixing the Ge particles with an organic binder and a carbon source; and pressing the Ge particles with the binder and the carbon source to form the electrode. Electrodes are also provided that include a plurality of microparticles comprising Ge grains, an organic binder, and a carbon source, wherein the Ge grains comprise cubic Ge and are bonded together to form Ge particles, and wherein the Ge grains define nanopores within the electrode.
FILED Wednesday, February 03, 2021
APPL NO 17/166076
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/134 (20130101)
H01M 4/622 (20130101)
H01M 4/625 (20130101)
H01M 4/1395 (20130101) Original (OR) Class
H01M 2004/021 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184363 MENDIS et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) BROWN UNIVERSITY (Providence, Rhode Island)
ASSIGNEE(S)
INVENTOR(S) Rajind MENDIS (Providence, Rhode Island);  Masaya NAGAI (Osaka, Japan);  Daniel M. MITTLEMAN (Providence, Rhode Island)
ABSTRACT An isolator based on a waveguide-based artificial dielectric medium is scalable to a range of desired terahertz frequencies, has non-reciprocal transmission and provides low insertion loss and high isolation at various tunable terahertz frequencies, far exceeding the performance of other terahertz isolators, and rivaling that of commercial optical isolators based on the Faraday effect. This approach offers a promising new route for polarization control of free-space terahertz beams in various instrumentation applications. Artificial dielectrics are man-made media that mimic properties of naturally occurring dielectric media, or even manifest properties that cannot generally occur in nature. A simple and effective strategy implements a polarizing-beam-splitter and a quarter wave plate to form a highly effective isolator. Performance of the device is believed to exceed that of any other experimentally demonstrated method for isolation of back-reflections for terahertz beams.
FILED Tuesday, March 13, 2018
APPL NO 16/494221
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 5/3008 (20130101)
G02B 5/3058 (20130101)
G02B 27/285 (20130101)

Antennas, i.e Radio Aerials
H01Q 15/242 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184495 Abur et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Ali Abur (Brookline, Massachusetts);  Pengxiang Ren (Boston, Massachusetts)
ABSTRACT Divergence of state estimation solutions for multi-area power grids typically occurs due to a single anomaly in the measurement set or network model, yet will cause failure of the state estimator to provide the solution for the entire system. Disclosed herein are methods and systems that allow detection, identification and isolation of the anomaly during the state estimation solution so that a large percentage of the system states can still be estimated, while isolating the anomaly that is causing the divergence for the estimator.
FILED Friday, December 11, 2020
APPL NO 17/119248
CURRENT CPC
Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 13/00028 (20200101) Original (OR) Class
H02J 2203/20 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184652 Tabrizian et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida);  OEM Group, LLC (Gilbert, Arizona)
ASSIGNEE(S)
INVENTOR(S) Roozbeh Tabrizian (Gainesville, Florida);  Farid S. Alokozai (Scottsdale, Arizona)
ABSTRACT A method for fabricating an acoustic wave resonator includes, in part, forming a micro-fin structure that includes one or more sidewalls on a substrate. The sidewalls are thereafter annealed. A bottom electrode layer is then deposited on top of the micro-fin structure. Afterwards, a layer of aluminum nitride is formed on the bottom electrode layer where the layer of aluminum nitride includes a textured aluminum nitride layer with a c-axis substantially perpendicular to the one or more sidewalls. A top electrode layer is then formed on top of the layer of aluminum nitride. In addition, the top electrode layer can be patterned, and the layer of aluminum nitride can be etched to provide access windows to the bottom electrode layer.
FILED Friday, December 11, 2020
APPL NO 17/119557
CURRENT CPC
Impedance Networks, e.g Resonant Circuits; Resonators
H03H 3/02 (20130101)
H03H 9/13 (20130101)
H03H 9/172 (20130101) Original (OR) Class
H03H 9/176 (20130101)
H03H 9/02031 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184988 Anwer et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) AT and T Intellectual Property I, L.P. (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Muhammad Bilal Anwer (Branchburg, New Jersey);  Aman Shaikh (Berkeley Heights, New Jersey);  Junzhi Gong (Cambridge, Massachusetts);  Minlan Yu (Cambridge, Massachusetts);  Yuliang Li (Cambridge, Massachusetts)
ABSTRACT Performance issues in a service function chain having a plurality of resources and a plurality of network functions each having a network function queue are diagnosed. Each network function queue is monitored and queueing information for input packets for each of the plurality of network functions is dumped to a data store. Each resource that is under contention is identified as well as which of the network functions is a contender for the resources. A diagnosing algorithm is used to diagnose performance problems and an impact graph for each victim packet is generated. A summary of results as a list of rules is then provided.
FILED Friday, December 13, 2019
APPL NO 16/714117
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 43/062 (20130101)
H04L 43/0876 (20130101)
H04L 47/522 (20130101)
H04L 47/746 (20130101)
H04L 47/748 (20130101)
H04L 47/762 (20130101) Original (OR) Class
H04L 47/803 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20210177297 Bouton
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
APPLICANT(S) Battelle Memorial Institute (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Chad E. Bouton (Powell, Ohio)
ABSTRACT A system and method enhance clinical effectiveness for monitoring for a change in a level of fluid in tissue by using a device attached to a body portion that wirelessly reports to a remote apparatus or receiver a current received power level for indications of extravasation or infiltration. Adjusting an activation rate of fluid detection, reporting or both extends service life of the device.
FILED Friday, February 26, 2021
APPL NO 17/249321
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0022 (20130101)
A61B 5/0507 (20130101) Original (OR) Class
A61B 5/0537 (20130101)
A61B 5/4839 (20130101)
A61B 5/4875 (20130101)
A61B 5/4878 (20130101)
A61B 5/6824 (20130101)
A61B 5/7203 (20130101)
A61B 5/7246 (20130101)
A61B 5/7282 (20130101)
A61B 8/08 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/16831 (20130101)
A61M 5/16836 (20130101)
A61M 2205/3317 (20130101)

Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps
F04C 2270/041 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210177756 NOY et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
National Science Foundation (NSF)
APPLICANT(S) Nga Thuy HO (, None);  Lawrence Livermore National Security, LLC (Livermore, California);  Max-Planck-Gesellschaft Zur Foerderung Dur Wissenschaften E.V. (Munich, Germany)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California);  Max-Planck-Gesellschaft Zur Foerderung Dur Wissenschaften E.V. (Munich, Germany)
INVENTOR(S) Aleksandr NOY (Livermore, California);  Nga Thuy HO (Oakland, California);  Gerhard HUMMER (Munchen, Germany);  Marc SIGGEL (Munchen, Germany)
ABSTRACT Disclosed herein is an engineered lipid-based vesicle optionally used for delivery of one or more payloads. The vesicle comprises a nanotube dimer or complex embedded with a lipid bilayer of the lipid-based vesicle. Also described herein are compositions, e.g., pharmaceutical compositions, and kits comprising the engineered lipid-based vesicle. In additional embodiments, further described herein are use of the engineered lipid-based vesicle for treating a disease or condition, for delivery to a target, or for labeling of a cell.
FILED Monday, December 14, 2020
APPL NO 17/121578
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/1271 (20130101) Original (OR) Class
A61K 31/65 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178323 Boscoboinik et al.
FUNDED BY
Department of Energy (DOE)
Brookhaven National Laboratory (BNL)
Brookhaven Science Associates, LLC (BSA)
Office of Science (DOEOS)
APPLICANT(S) Brookhaven Science Associates, LLC (Upton, New York)
ASSIGNEE(S)
INVENTOR(S) Jorge A. Boscoboinik (Stony Brook, New York);  Mengen Wang (Coram, New York);  Deyu Lu (South Setauket, New York);  Nusnin Akter (Bronx, New York);  Jianqiang Zhang (Berlin, Germany);  Yixin Xu (Port Jefferson, New York);  Dario J. Stacchiola (South Setauket, New York);  Alejandro Miguel Boscoboinik (Milwaukee, Wisconsin)
ABSTRACT A method for trapping noble gas atoms and molecules in oxide nanocages that includes providing oxide nanocages on a metallic substrate, ionizing a noble gas to form noble gas cations, applying a voltage to the metallic substrate, contacting the oxide nanocages with the noble gas cations, and deionizing the cations to form noble gas atoms and molecules that are trapped within the oxide nanocages. In one embodiment of the present device, polygonal prism organosilicate cages on a ruthenium thin film can trap noble gases.
FILED Monday, August 31, 2020
APPL NO 17/008198
CURRENT CPC
Separation
B01D 53/32 (20130101) Original (OR) Class
B01D 53/76 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/3204 (20130101)
B01J 20/3297 (20130101)
B01J 20/28042 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210178996 Verma et al.
FUNDED BY
Department of Energy (DOE)
Pacific Northwest National Laboratory (PNNL)
UT-Battelle, LLC (UT-BATTELLE)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Kiren E. Verma (Oak Ridge, Tennessee);  Robert A. Bridges (Oak Ridge, Tennessee);  Samuel C. Hollifield (Oak Ridge, Tennessee)
ABSTRACT A system and method for decoding an unknown automotive controller area network (“CAN”) message definitions. CAN data vehicle signal mappings are typically held in secret and varied by automotive model and year. Without knowledge of the mappings, the wealth of real-time vehicle data hidden in the automotive CAN packets is uninterpretable—impeding research, after-market tuning, efficiency and performance monitoring, fault diagnosis, and privacy-related technologies. This technology can ascertain the CAN signals' boundaries (start bit and length), endianness (byte ordering), signedness (binary-to-integer encoding) from raw CAN data. This allows conversion of CAN data to time series. Interpreting the translated CAN data's physical meaning and finding a linear mapping to standard units (e.g., knowing the signal is speed and scaling values to represent units of miles per hour) can be achieved for many signals by leveraging diagnostic standards to obtain real-time measurements of in-vehicle systems. The system and method can be integrated into lightweight hardware enabling an OBD-II plugin for real-time in-vehicle CAN decoding or run on standard computers. The system can output a standard DBC file with the signal definition information.
FILED Thursday, December 10, 2020
APPL NO 17/117535
CURRENT CPC
Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for
B60R 16/0232 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere
G07C 5/008 (20130101)
G07C 5/10 (20130101)
G07C 5/0808 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179432 Preda et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) Physical Sciences, Inc. (Andover, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Dorin V. Preda (Medford, Massachusetts);  Min K. Song (Newark, Delaware);  Jake T. Herb (West Chester, Pennsylvania);  Christopher M Lang (Hampstead, New Hampshire);  David P. Gamliel (Medford, Massachusetts)
ABSTRACT A method of producing high conductivity carbon material from coal includes subjecting the coal to a dissolution process to produce a solubilized coal material, and subjecting the solubilized coal material to a pyrolysis process to produce the high conductivity carbon material.
FILED Thursday, December 10, 2020
APPL NO 17/117538
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 32/184 (20170801) Original (OR) Class
C01B 2204/22 (20130101)
C01B 2204/30 (20130101)
C01B 2204/32 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2004/03 (20130101)

Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases
C10J 3/46 (20130101)
C10J 2300/093 (20130101)
C10J 2300/1625 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179759 Lee et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Laboratory (LANL)
National Nuclear Security Administration (NNSA)
Triad National Security, LLC (Triad)
APPLICANT(S) Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S) Triad National Security, LLC. (, None)
INVENTOR(S) Matthew N. Lee (Los Alamos, New Mexico);  Nicholas G. Parra-Vasquez (Los Alamos, New Mexico);  Kyle J. Cluff (Los Alamos, New Mexico)
ABSTRACT Disclosed herein are embodiments of a printable composition that can be used to make printed products of a chosen material chemistry that have different levels of porosity within the printed product's structure Also disclosed herein are embodiments of a printed product that has multiple levels of porosity throughout its structure, which can include a macroscale level of porosity, a microscale level of porosity, a nanoscale level of porosity and any combination thereof. These printed products can be made using a 3-D printer and can be made from a single printable composition without the need to add different structural components during the production process. Also disclosed herein are embodiments of a method for making and using a printed product.
FILED Friday, February 01, 2019
APPL NO 16/265641
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 3/008 (20130101)

Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster
B28B 1/001 (20130101)

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/124 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 70/00 (20141201)
B33Y 80/00 (20141201)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 222/20 (20130101) Original (OR) Class

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 4/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179844 Bova et al.
FUNDED BY
Department of Energy (DOE)
Pacific Northwest National Laboratory (PNNL)
UT-Battelle, LLC (UT-BATTELLE)
Oak Ridge National Laboratory (ORNL)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee);  University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee);  University of Tennessee Research Foundation (Knoxville, Tennessee)
INVENTOR(S) Anthony S. Bova (McLean, Virginia);  Amit K. Naskar (Knoxville, Tennessee)
ABSTRACT A solid multiphase polymer blend material comprising: (i) a polyphenolic substance having a molecular weight of at least 500 g/mol; and (ii) a polyester having a molecular weight of at least 500 g/mol; wherein at least a portion of the polyphenolic substance is covalently bonded directly or through a linking moiety to the polyester. Methods for producing the blend material are also described, e.g., homogeneously melt blending a mixture comprising components (i) and (ii) under conditions resulting in covalent attachment of at least a portion of the polyphenolic substance directly or through a linking moiety to the polyester. Methods for producing objects made of the blend material by melt extrusion are also described.
FILED Friday, January 29, 2021
APPL NO 17/162658
CURRENT CPC
Compositions of Macromolecular Compounds
C08L 67/03 (20130101)
C08L 67/04 (20130101) Original (OR) Class
C08L 71/02 (20130101)
C08L 97/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179879 Boyle et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Timothy J. Boyle (Albuquerque, New Mexico);  Nelson S. Bell (Albuquerque, New Mexico);  Adam W. Cook (Albuquerque, New Mexico);  Jessica Rimsza (Albuquerque, New Mexico);  Ethan Benjamin Secor (Ames, Iowa)
ABSTRACT Metal hydride nanoparticle inks provide an alternative to traditional metal inks. Metal hydride nanoinks can be printed by aerosol jet printing and cured at elevated temperatures to provide conductive patterns. As an example, printed patterns of titanium hydride nanoink on polyimide and cured by pulsed photonic curing were found to exhibit electrical conductivity, with a sheet resistance on the order of ˜150 Ω/□.
FILED Tuesday, December 08, 2020
APPL NO 17/114839
CURRENT CPC
Typewriters; Selective Printing Mechanisms,, i.e Mechanisms Printing Otherwise Than From a Forme; Correction of Typographical Errors
B41J 2/175 (20130101)
B41J 2/442 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 6/02 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 11/03 (20130101)
C09D 11/52 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179889 KIM et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Adaptive Surface Technologies, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Philseok KIM (Waltham, Massachusetts);  Teluka Pasan GALHENAGE (Chestnut Hill, Massachusetts);  Joseph LOMAKIN (Arlington, Massachusetts)
ABSTRACT The present teachings generally provide curable polysiloxane compositions including a base resin including a surface active polymer. Articles of manufacture including the curable polysiloxane compositions and slippery coatings and materials also are provided. The compositions may be used to provide slippery, lubricious, or repellent materials and coatings and may provide anti-fouling function. The compositions can provide anti-fouling or foul-release function on open surfaces, internal surfaces, membranes; to provide pinning free or low contact angle hysteresis surfaces; to provide homogeneous interface to suppress nucleation; to provide a barrier layer such as anti-corrosion; to provide anti-stain, anti-smudge, anti-fingerprint, anti-soil function.
FILED Tuesday, February 23, 2021
APPL NO 17/183184
CURRENT CPC
Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 3/26 (20130101)
B32B 7/12 (20130101)
B32B 9/04 (20130101)
B32B 25/04 (20130101)
B32B 25/06 (20130101)
B32B 25/10 (20130101)
B32B 25/20 (20130101)
B32B 27/06 (20130101)
B32B 27/10 (20130101)
B32B 27/12 (20130101)
B32B 27/20 (20130101)
B32B 27/30 (20130101)
B32B 27/283 (20130101)
B32B 27/285 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 77/16 (20130101)
C08G 77/28 (20130101)

Compositions of Macromolecular Compounds
C08L 83/04 (20130101)
C08L 83/08 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 5/1675 (20130101)
C09D 183/04 (20130101) Original (OR) Class

Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition
C10M 107/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180007 BECKHAM et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
UT-Battelle, LLC (UT-BATTELLE)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado);  UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Gregg Tyler BECKHAM (Golden, Colorado);  Thelhawadigedara Lahiru Niroshan JAYAKODY (Wheat Ridge, Colorado);  Adam Michael GUSS (Oak Ridge, Tennessee);  Thomas David MAND (Oak Ridge, Tennessee);  Christopher W. JOHNSON (Denver, Colorado);  Isabel PARDO MENDOZA (Dos Hermanas, Spain)
ABSTRACT Disclosed herein are engineered P. putida KT2440 co-expressing PETase and MHETase enzymes that selectively degrades PET into monomers, ethylene glycol and terephthalate (TPA). In another embodiment, disclosed herein are methods for making and using a highly efficient EG metabolizing P. putida KT2440 strain. Given that native P. putida does not have a TPA metabolic pathway, nor the proteins to transport TPA into the cell, the next metabolic engineering challenge for developing synthetic P. putida strain to plastic upcycling was enabling TPA catabolism in P. putida KT2440. TPA transporters and catabolic pathway have been characterized in several microorganisms including Comamonas sp. strain E6 and Rhodococcus jostii RHA1.
FILED Wednesday, May 15, 2019
APPL NO 17/055626
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101) Original (OR) Class
C12N 9/18 (20130101)

Enzymes
C12Y 301/01 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180165 Pasebani et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency Energy (ARPAE)
APPLICANT(S) Oregon State University (Corvallis, Oregon)
ASSIGNEE(S) Oregon State University (Corvallis, Oregon)
INVENTOR(S) Somayeh Pasebani (Corvallis, Oregon);  S. Milad Ghayoor Baghbani (Corvallis, Oregon);  Brian K. Paul (Corvallis, Oregon);  Chih-hung Chang (Corvallis, Oregon);  Kijoon Lee (Corvallis, Oregon);  Yujuan He (Corvallis, Oregon)
ABSTRACT Disclosed herein are embodiments of an additive-containing alloy that exhibit improved strength, particularly at high temperatures, creep resistance, thermal fatigue resistance, and oxidation resistance. Also disclosed herein are embodiments of a method for making such additive-containing alloys, including methods whereby the additive component of such alloys can be selectively deposited according to a pre-designed pattern. Such method embodiments facilitate producing programmable alloy embodiments wherein the additive component can be provided in desired regions of the alloy and/or at desired concentrations within the alloy.
FILED Monday, February 22, 2021
APPL NO 17/181955
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering
C21D 8/005 (20130101)

Alloys
C22C 38/34 (20130101)
C22C 38/58 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180174 BRADY et al.
FUNDED BY
Department of Energy (DOE)
UT-Battelle, LLC (UT-BATTELLE)
APPLICANT(S) Regents of the University of Minnesota (Minneapolis, Minnesota);  UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Michael P. BRADY (Oak Ridge, Tennessee);  Orlando RIOS (Knoxville, Tennessee);  YanFeng JIANG (Berkeley, California);  Gerard M. LUDTKA (Oak Ridge, Tennessee);  Craig A. BRIDGES (Knoxville, Tennessee);  Jian-Ping WANG (Shoreview, Minnesota);  Xiaowei ZHANG (Minneapolis, Minnesota);  Lawrence F. ALLARD (Knoxville, Tennessee);  Edgar LARA-CURZIO (Lenoir City, Tennessee)
ABSTRACT A method may include annealing a material including iron and nitrogen in the presence of an applied magnetic field to form at least one Fe16N2 phase domain. The applied magnetic field may have a strength of at least about 0.2 Tesla (T).
FILED Tuesday, February 23, 2021
APPL NO 17/182857
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 21/0622 (20130101)

Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering
C21D 1/26 (20130101)
C21D 6/00 (20130101)

Alloys
C22C 33/00 (20130101)
C22C 38/00 (20130101)
C22C 38/001 (20130101)

Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 8/26 (20130101) Original (OR) Class
C23C 28/34 (20130101)
C23C 28/322 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 1/047 (20130101)
H01F 1/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180191 FOULIARD et al.
FUNDED BY
Department of Energy (DOE)
National Energy Technology Laboratory (NETL)
APPLICANT(S) UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
ASSIGNEE(S)
INVENTOR(S) Quentin FOULIARD (Winter Park, Florida);  Ranajay Ghosh (Oviedo, Florida);  Seetha Raghavan (Oviedo, Florida)
ABSTRACT A thermal barrier coated component, such as a turbine blade formed from a superalloy substrate, includes a thermal barrier coating applied onto the substrate. A metallic bond coat layer is on the substrate and includes rare-earth luminescent dopants. A ceramic top coat layer is on the bond coat layer. A temperature sensing thermally grown oxide (TGO) layer is formed at the interface of the bond coat layer and ceramic top coat layer. The temperature sensing TGO layer includes grown rare-earth luminescent ions migrated from the metallic bond coat layer in an amount sufficient to enable luminescence sensing of the TGO layer for real-time phosphor thermometry temperature measurements at the TGO layer.
FILED Monday, September 28, 2020
APPL NO 17/034065
CURRENT CPC
Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/7783 (20130101)

Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 28/321 (20130101)
C23C 28/3455 (20130101) Original (OR) Class

Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for
G01K 11/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180284 Mo et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) University of Houston System (Houston, Texas)
ASSIGNEE(S) University of Houston System (Houston, Texas)
INVENTOR(S) Yi-Lung Mo (Pearland, Texas);  Fnu Witarto (Houston, Texas)
ABSTRACT A seismic isolation system for underground structures comprises a periodic foundation and periodic arrays of piles in the soil or periodic piles that surround the underground structure. The periodic foundation may be a foundation of periodic materials. The periodic piles can substantially reduce the incoming seismic waves from the lateral direction. The periodic piles may be vertically arranged layers of periodic materials. The combination of the periodic foundation and periodic piles can result in total isolation for the underground structure. This total isolation may be of particular interest for underground facilities, such as underground nuclear power plants and structures with basements.
FILED Wednesday, February 01, 2017
APPL NO 16/074227
CURRENT CPC
Foundations; Excavations; Embankments; Underground or Underwater Structures
E02D 27/34 (20130101)
E02D 29/045 (20130101) Original (OR) Class

Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General
E04H 9/022 (20130101)

Springs; Shock-absorbers; Means for Damping Vibration
F16F 15/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181027 Bora
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Mihail Bora (Livermore, California)
ABSTRACT Exemplary methods for detecting presence of water in a sample include: heating a light source to a predetermined temperature at which the light source emits thermal radiation; placing a sample between the light source and a detector; transmitting the thermal radiation from the light source through the sample and onto the detector; and determining a presence or an absence of water within the sample based on the thermal radiation transmitted onto the detector. Exemplary systems for detecting presence of water in a sample are also disclosed.
FILED Tuesday, February 23, 2021
APPL NO 17/183122
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 5/0037 (20130101)
G01J 5/0806 (20130101)
G01J 5/0896 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182070 GUO et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) DAHAI GUO (CHAMPAIGN, Illinois);  DAVID GEORGE SOLT (FRISCO, Texas);  JOSHUA J. HURSEY (LA CROSSE, Wisconsin);  AUSTEN WILLIAM LAURIA (WAPPINGERS FALLS, New York);  XIN GUO (BEIJING CITY, China PRC)
ABSTRACT A method uses an explicit resource file (ERF) to repetitively execute a set of processes using consistent resources. The method generates the ERF for a set of processes. The ERF identifies one or more specified central processing units (CPUs), one or more specified graphics processing units (GPUs), and one or more memory ranges in memory to be used by the one or more specified CPUs and the one or more specified GPUs when executing the set of processes. The method enforces compliance with the ERF when repetitively executing the set of processes.
FILED Wednesday, December 11, 2019
APPL NO 16/710816
CURRENT CPC
Electric Digital Data Processing
G06F 9/3855 (20130101) Original (OR) Class
G06F 9/3887 (20130101)
G06F 9/3889 (20130101)

Image Data Processing or Generation, in General
G06T 1/20 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 67/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182193 NA et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
Lawrence Livermore National Laboratory (LLNL)
APPLICANT(S) ADVANCED MICRO DEVICES, INC. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Weon Taek NA (Bellevue, Washington);  Jagadish B. KOTRA (Austin, Texas);  Yasuko ECKERT (Bellevue, Washington);  Steven RAASCH (Boxborough, Massachusetts);  Sergey BLAGODUROV (Bellevue, Washington)
ABSTRACT A processing system selectively allocates space to store a group of one or more cache lines at a cache level of a cache hierarchy having a plurality of cache levels based on memory access patterns of a software application executing at the processing system. The processing system generates bit vectors indicating which cache levels are to allocate space to store groups of one or more cache lines based on the memory access patterns, which are derived from data granularity and movement information. Based on the bit vectors, the processing system provides hints to the cache hierarchy indicating the lowest cache level that can exploit the reuse potential for a particular data.
FILED Friday, December 13, 2019
APPL NO 16/713940
CURRENT CPC
Electric Digital Data Processing
G06F 9/30036 (20130101)
G06F 12/0811 (20130101) Original (OR) Class
G06F 12/0831 (20130101)
G06F 12/0871 (20130101)
G06F 12/0882 (20130101)
G06F 12/1027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182213 Yin et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
Lawrence Livermore National Laboratory (LLNL)
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Jieming Yin (Bothell, Washington);  Yasuko Eckert (Redmond, Washington);  Subhash Sethumurugan (Minneapolis, Minnesota)
ABSTRACT Systems, apparatuses, and methods for implementing cache line re-reference interval prediction using a physical page address are disclosed. When a cache line is accessed, a controller retrieves a re-reference interval counter value associated with the line. If the counter is less than a first threshold, then the address of the cache line is stored in a small re-use page buffer. If the counter is greater than a second threshold, then the address is stored in a large re-use page buffer. When a new cache line is inserted in the cache, if its address is stored in the small re-use page buffer, then the controller assigns a high priority to the line to cause it to remain in the cache to be re-used. If a match is found in the large re-use page buffer, then the controller assigns a low priority to the line to bias it towards eviction.
FILED Monday, December 16, 2019
APPL NO 16/716165
CURRENT CPC
Electric Digital Data Processing
G06F 12/122 (20130101) Original (OR) Class
G06F 2212/1021 (20130101)
G06F 2212/1044 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182216 Yin et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
Lawrence Livermore National Laboratory (LLNL)
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Jieming Yin (Bothell, Washington);  Yasuko Eckert (Redmond, Washington);  Subhash Sethumurugan (Minneapolis, Minnesota)
ABSTRACT Systems, apparatuses, and methods for cache management based on access type priority are disclosed. A system includes at least a processor and a cache. During a program execution phase, certain access types are more likely to cause demand hits in the cache than others. Demand hits are load and store hits to the cache. A run-time profiling mechanism is employed to find which access types are more likely to cause demand hits. Based on the profiling results, the cache lines that will likely be accessed in the future are retained based on their most recent access type. The goal is to increase demand hits and thereby improve system performance. An efficient cache replacement policy can potentially reduce redundant data movement, thereby improving system performance and reducing energy consumption.
FILED Monday, December 16, 2019
APPL NO 16/716194
CURRENT CPC
Electric Digital Data Processing
G06F 12/126 (20130101) Original (OR) Class
G06F 2212/602 (20130101)
G06F 2212/1021 (20130101)
G06F 2212/1044 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182385 Roychowdhury et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) GENERAL ELECTRIC COMPANY (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Subhrajit Roychowdhury (Schenectady, New York);  Masoud Abbaszadeh (Clifton Park, New York);  Mustafa Tekin Dokucu (Latham, New York)
ABSTRACT An industrial asset may have monitoring nodes (e.g., sensor or actuator nodes) that generate current monitoring node values. An abnormality detection and localization computer may receive the series of current monitoring node values and output an indication of at least one abnormal monitoring node that is currently being attacked or experiencing a fault. An actor-critic platform may tune a dynamic, resilient state estimator for a sensor node and output tuning parameters for a controller that improve operation of the industrial asset during the current attack or fault. The actor-critic platform may include, for example, a dynamic, resilient state estimator, an actor model, and a critic model. According to some embodiments, a value function of the critic model is updated for each action of the actor model and each action of the actor model is evaluated by the critic model to update a policy of the actor-critic platform.
FILED Wednesday, December 11, 2019
APPL NO 16/710051
CURRENT CPC
Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 13/027 (20130101)
G05B 13/042 (20130101)
G05B 13/048 (20130101)

Electric Digital Data Processing
G06F 21/552 (20130101) Original (OR) Class
G06F 2221/034 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)
G06N 3/0454 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210183555 Hartman et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Science Foundation (NSF)
APPLICANT(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S) Seth Hartman (Belton, Missouri);  Erik Timpson (Lee's Summit, Missouri)
ABSTRACT An electromagnetic propulsion system is provided. The system comprises first and second pluralities of stator coils wound about first and second axes, a plurality of support structures, first and second couplers that surround portions of the first and second pluralities of stator coils, and first and second pluralities of sets of rotor coils wound about axes that are parallel to the first and second axes. The stator coils are configured to receive electric current through an outside controller selecting appropriately coupled stator sections or through a sliding electrical contact system or bearing system to induce at least a first magnetic field. The plurality of support structures supports the first and second plurality of stator coils. The first and second couplers include notches and are oriented so that their notches pass over the plurality of support structures when the couplers move along the stator coils. The couplers may have an adjustable segment to close the notch. The sets of rotor coils are equidistantly attached to the couplers and are configured to receive electric current to induce magnetic fields that interact with the magnetic fields of the stator coils so that magnetic forces are applied to the plurality of rotor coils, thereby propelling the couplers along the stator coils.
FILED Thursday, December 12, 2019
APPL NO 16/711776
CURRENT CPC
Weapons for Projecting Missiles Without Use of Explosive or Combustible Propellant Charge; Weapons Not Otherwise Provided for
F41B 6/006 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 7/17 (20130101)
H01F 7/064 (20130101) Original (OR) Class

Dynamo-electric Machines
H02K 1/2786 (20130101)
H02K 5/167 (20130101)
H02K 7/09 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184200 Dharmasena et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
ASSIGNEE(S) GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
INVENTOR(S) Ruchira R. Dharmasena (Shelby Township, Michigan);  Shuru Chen (Troy, Michigan);  Fang Dai (Troy, Michigan);  Mei Cai (Bloomfield Hills, Michigan)
ABSTRACT A method of applying a homogenous film coating to a constituent particle of component includes setting up a target element in a sputtering chamber. The method also includes arranging a receptacle in the sputtering chamber. The method additionally includes arranging the constituent particle on the receptacle. The method also includes bombarding the target element via energetic particles to eject material from the target element and deposit the material onto the constituent particle. The method further includes agitating the receptacle during the bombarding to apply the material to the constituent particle as the homogenous film coating. The method may be used to apply a homogenous thin film coating to a sulfur-infused constituent particle for a sulfur cathode in a lithium-sulfur battery.
FILED Wednesday, December 11, 2019
APPL NO 16/710793
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/34 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/045 (20130101)
H01M 4/136 (20130101)
H01M 4/0426 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184364 Han et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Jinkyu Han (San Ramon, California);  Thomas Han (Livermore, California)
ABSTRACT A product includes a nanostructure having a core and a shell. The core has a coercive field of at least 3 kOe and the shell has a saturation magnetization of at least 50 emu per gram. A product includes a nanostructure having a core and a shell. The shell has a coercive field of at least 3 kOe and the core has a saturation magnetization of at least 50 emu per gram. A method includes forming core/shell nanostructures and forming millimeter wave absorbers including the core/shell nanostructures and a support structure.
FILED Thursday, December 12, 2019
APPL NO 16/712812
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 25/00 (20130101)

Antennas, i.e Radio Aerials
H01Q 17/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184470 DALL'ANESE et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado);  Université catholique de Louvain (Louvain-la-Neuve, Belgium)
ASSIGNEE(S)
INVENTOR(S) Emiliano DALL'ANESE (Arvada, Colorado);  Andrey BERNSTEIN (Golden, Colorado);  Andrea SIMONETTO (Wavre, Belgium)
ABSTRACT An example device includes a processor configured to receive a plurality of voltage values representing respective voltage magnitudes at voltage nodes in a first portion of a power system and determine, for each voltage node, a respective value of first and second voltage-constraint coefficients. The processor is also configured to receive a power value corresponding to a connection point of the first portion of the power system with a second portion of the power system and determine for the connection point, a respective value of first and second power-constraint coefficients. The processor is also configured to cause at least one energy resource connected to the first portion of the power system to modify an output power of the at least one energy resource based on the value of the first and second voltage-constraint coefficients for each voltage node and the value of the first and second power-constraint coefficients.
FILED Friday, February 05, 2021
APPL NO 17/168810
CURRENT CPC
Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 19/042 (20130101)
G05B 2219/2639 (20130101)

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 3/00 (20130101)
H02J 3/32 (20130101)
H02J 3/46 (20130101)
H02J 3/381 (20130101) Original (OR) Class
H02J 2203/20 (20200101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 40/70 (20130101)
Y02E 60/00 (20130101)

Systems Integrating Technologies Related to Power Network Operation, Communication or Information Technologies for Improving the Electrical Power Generation, Transmission, Distribution, Management or Usage, i.e Smart Grids
Y04S 40/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184578 ERICKSON et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency Energy (ARPAE)
APPLICANT(S) The Regents of the University of Colorado, a body (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Robert ERICKSON (Boulder, Colorado);  Dragan MAKSIMOVIC (Boulder, Colorado);  Vivek SANKARANARAYANAN (Boulder, Colorado);  Aritra GHOSH (Boulder, Colorado);  Yucheng GAO (Boulder, Colorado)
ABSTRACT A bidirectional composite converter is provided. The bidirectional composite converter can be used with power electronics, such as but not limited to electric vehicles and other applications. In some implementations, for example, the composite converter may be used in a powertrain of an electric vehicle to couple batteries to a high voltage bus of the vehicle to provide power to the motors and to one or more integrated charging ports (e.g., ac grid wired connections or a wireless charging port) for extremely fast charging. In various implementations, the bidirectional converter architecture may comprise one or more dc transformer modules (DCX's) arranged with output port(s) coupled in series at an output port of the composite converter.
FILED Friday, August 16, 2019
APPL NO 17/268776
CURRENT CPC
Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 7/02 (20130101)

Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof
H02M 3/1582 (20130101) Original (OR) Class
H02M 3/33584 (20130101)
H02M 2001/0054 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20210180076 QI
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Organismal Systems (IOS)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) YIPING QI (POTOMAC, Maryland)
ABSTRACT Compositions and methods for modifying genomic DNA sequences of a plant cell are provided. The methods produce double stranded breaks at target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. The compositions comprise DNA constructs comprising nucleotide sequences that encode a Cas12b protein. The DNA constructs can be used to direct the modification of genomic DNA at a target site. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.
FILED Thursday, December 17, 2020
APPL NO 17/247582
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/8213 (20130101) Original (OR) Class
C12N 15/8216 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181115 He et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Lili He (Belchertown, Massachusetts);  Haoxin Chen (Amherst, Massachusetts);  Zhuansheng Lin (Boston, Massachusetts)
ABSTRACT The present disclosure provides a surface enhanced Raman scattering substrate assembly for detecting an analyte. The assembly can include an etched fiber base. The assembly can further include a metallic nanoparticle coating disposed over at least a portion of the surface etched fiber base.
FILED Wednesday, February 03, 2021
APPL NO 17/166204
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/658 (20130101) Original (OR) Class
G01N 33/025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210181174 RIVERS
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) ADAM R. RIVERS (GAINESVILLE, Florida)
ABSTRACT Volatile organic chemicals emitted by a shell egg embryo are used to identify the fertility, viability, and sex of the shell egg embryo. Shortly after the egg is laid, the egg is isolated in a vapor-tight compartment so that a vapor containing volatile organic chemicals emitted by the shell egg embryo collect in the headspace of the compartment. The chemicals in the vapor are analyzed to construct a chemical profile of the shell egg embryo, and then the chemical profile of the shell egg embryo vapor is loaded into a previously developed model. Based on the data generated by the model, the shell egg is embryo is predicted to be an alive male, an alive female, an infertile egg, or an egg containing a dead embryo.
FILED Monday, December 14, 2020
APPL NO 17/120656
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 43/00 (20130101)
A01K 45/007 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/08 (20130101) Original (OR) Class
G01N 33/6848 (20130101)
G01N 2560/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210185869 Deng
FUNDED BY
Department of Agriculture (USDA)
Agricultural Research Service (ARS)
Tropical and Subtropical Agricultural Research (TSTAR)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Florida Foundation Seed Producers, Inc. (Marianna, Florida)
ASSIGNEE(S)
INVENTOR(S) Zhanao Deng (Riverview, Florida)
ABSTRACT A new and distinct cultivar of Lantana camara plant named ‘UF-1013-1’, characterized by its moderate vigor, mounding growth habit, dense branches, round plant form and canopy, free flowering, bright yellow and red flowers, no to little fruiting, no to few seeds, a very high level of female infertility, a very low level of pollen stainability and viability, a very high level of male infertility, lack of hybridization with Lantana depressa, triploidy and a unique combination of DNA marker alleles, is disclosed.
FILED Wednesday, December 02, 2020
APPL NO 16/974252
CURRENT CPC
Plants
PLT/227
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Commerce (DOC) 

US 20210179234 Cardenas et al.
FUNDED BY
Department of Commerce (DOC)
National Oceanic and Atmospheric Administration (NOAA)
APPLICANT(S) Boston Engineering Corporation (Waltham, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Robert Lee Cardenas (Framingham, Massachusetts);  Michael Conry (Beverly, Massachusetts);  Michael Rufo (Hanover, Massachusetts);  Todd Scrimgeour (Brighton, Massachusetts)
ABSTRACT A variable buoyancy device has an inner region and an outer cavity. The outer cavity extends at least partially around the inner region and is adapted to contain fluids, such as a liquid and a gas, the relative proportions of which can be varied to vary buoyancy. The inner region provides an advantageous location for equipment, while the outer cavity provides a significant volume for achieving a wide range of buoyancy adjustments.
FILED Tuesday, December 15, 2020
APPL NO 17/122527
CURRENT CPC
Ships or Other Waterborne Vessels; Equipment for Shipping
B63B 22/20 (20130101) Original (OR) Class
B63B 79/40 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179639 Woodcock et al.
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)
INVENTOR(S) Jeremiah Wallace Woodcock (Gaithersburg, Maryland);  Jeffrey William Gilman (Mt. Airy, Maryland);  Douglas Matthew Fox (Reston, Virginia)
ABSTRACT A physiologically stable fluorophore includes a terminal moiety including a terminal reactive site that reacts with a reactive group of a substrate; a stability linker covalently bonded to the terminal moiety; and a bridge moiety covalently bonded to the stability linker such that the stability linker is interposed through chemical bonds between the bridge moiety and the terminal moiety; and a fluorescent moiety covalently bonded to the bridge moiety of the redox moiety and including: an electron bandgap mediator that is covalently bonded to the bridge moiety; a coordinate center covalently bonded to the electron bandgap mediator and that forms a Zwitterionic member with an atom in the electron bandgap mediator; and a steric hinder bonded to the electron bandgap mediator to provide steric hindrance for protection of the coordinate center.
FILED Thursday, December 10, 2020
APPL NO 17/117424
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0021 (20130101)

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 5/022 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179653 Woodcock et al.
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)
INVENTOR(S) Jeremiah Wallace Woodcock (Gaithersburg, Maryland);  Douglas Matthew Fox (Reston, Virginia);  Veronika Ann Szalai (Gaithersburg, Maryland)
ABSTRACT A redox reversible fluorescent probe for performing single-electron transfer fluorescence probing includes: a redox moiety including: a terminal moiety; an electron transfer metal coordinatively bonded to the terminal moiety; and a bridge moiety coordinatively bonded to the electron transfer metal; and a fluorescent moiety covalently bonded to the bridge moiety of the redox moiety and comprising: an electron bandgap mediator that is covalently bonded to the bridge moiety; a coordinate center covalently bonded to the electron bandgap mediator and that forms a Zwitterionic member with an atom in the electron bandgap mediator; and a steric hinder bonded to the electron bandgap mediator to provide steric hindrance for protection of the coordinate center.
FILED Monday, December 07, 2020
APPL NO 17/113228
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 17/02 (20130101) Original (OR) Class

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/07 (20130101)
C09K 2211/187 (20130101)
C09K 2211/1007 (20130101)
C09K 2211/1491 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/77 (20130101)
G01N 2021/7786 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

United States Postal Service (USPS) 

US 20210181359 McLellan et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Charles P. McLellan (Fairfax, Virginia);  Collier C. Apgar (Washington, District of Columbia)
ABSTRACT A system and method for tracking mobile devices. The system can include a data center and a plurality of mobile devices in communication with the data center via the network. Each mobile device can include at least one sensor configured to periodically generate tracking data records, a memory, and a processor in communication with the at least one sensor and the memory. The mobile devices can transmit sets of tracking data records to the data center using reduced bandwidth relative to the original records by implement compression algorithms that can include delta encoding and/or numeric base conversion of number valued fields, as well as additional compression techniques that may be reversed at the data center to reconstruct the original records or otherwise decompress the data.
FILED Friday, December 11, 2020
APPL NO 17/119990
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 19/42 (20130101) Original (OR) Class

Electric Digital Data Processing
G06F 16/13 (20190101)

Wireless Communication Networks
H04W 4/029 (20180201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182787 Mouli et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Venkat Mouli (Chantilly, Virginia);  Fharon M. Hicks (Washington, District of Columbia)
ABSTRACT Systems and methods for analyzing and improving delivery resource operation and efficiency. A delivery resource carries a mobile computing device which transmits delivery information to a server. The server combines the delivery information with stored route information for the route the delivery resource traverses to identify anomalies, to change routing, to dispatch additional resources, provide delivery predictions, and to improve overall performance.
FILED Monday, December 14, 2020
APPL NO 17/121464
CURRENT CPC
Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/047 (20130101)
G06Q 10/0838 (20130101) Original (OR) Class
G06Q 10/08355 (20130101)

Wireless Communication Networks
H04W 4/024 (20180201)
H04W 4/029 (20180201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210182792 Aryeetey et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, Delaware)
ASSIGNEE(S)
INVENTOR(S) Nii-Kwashie Aryeetey (Washington, District of Columbia);  Robert E. Dixon, JR. (Washington, District of Columbia);  Naomi Miller (Washington, District of Columbia)
ABSTRACT Systems and methods for generating and implementing a household customer database are disclosed. In one aspect, a method for processing items comprises receiving a first item to be delivered and identifying data corresponding to one or more of a source information and destination information of the first item. The method further comprises identifying secondary information of the first item, storing the source, destination, and secondary information in a database, creating associations between the source, destination, and secondary information, receiving a request to analyze information stored and associated in the database, determining whether the database comprises information necessary to perform the requested analysis, identifying if additional information is needed to perform the requested analysis, updating the secondary information associations to include the additional information if needed to perform the requested analysis, and analyzing the information stored and associated in the database based on the received analysis request or query.
FILED Monday, February 01, 2021
APPL NO 17/163809
CURRENT CPC
Electric Digital Data Processing
G06F 21/602 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/0838 (20130101)
G06Q 10/08355 (20130101) Original (OR) Class
G06Q 2220/00 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Education (ED) 

US 20210177626 Kuiken et al.
FUNDED BY
Department of Education (ED)
Office of Special Education and Rehabilitative Services (OSERS)
National Institute on Disability and Rehabilitation Research (NIDRR)
APPLICANT(S) Rehabilitation Institute of Chicago d/b/a Shirley Ryan AbilityLab (Chicago, Illinois)
ASSIGNEE(S) Rehabilitation Institute of Chicago d/b/a Shirley Ryan AbilityLab (Chicago, Illinois)
INVENTOR(S) Todd Kuiken (Chicago, Illinois);  Frank Ursetta (Chicago, Illinois)
ABSTRACT The present disclosure is directed to a compact wrist rotator and flexor mechanism for use with a prosthetic hand. The wrist rotator and flexor uses a set of motors to provide a driven mechanism having two degrees of freedom, a wrist rotation and a wrist flexion. The rotator uses a motor with an inverted shaft gearbox combined with a worm gear and a face gear transmission to generate continuous and non-backdrivable rotation. The rotator is integrated into a flexor that uses a lead screw acting as a linear actuator to provide strong non-backdrivable flexion and extension. Due to the arrangement of the drives, the resulting wrist rotator and flexor mechanism has a low and compact profile.
FILED Monday, December 14, 2020
APPL NO 17/121288
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/68 (20130101)
A61F 2/80 (20130101)
A61F 2/585 (20130101) Original (OR) Class
A61F 2002/6836 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210179588 Hollis et al.
FUNDED BY
Department of Education (ED)
National Science Foundation (NSF)
APPLICANT(S) Mississippi State University (Starkville, Mississippi)
ASSIGNEE(S)
INVENTOR(S) Thedford Keith Hollis (Starkville, Mississippi);  Charles Edwin Webster (Starkville, Mississippi)
ABSTRACT Provided herein are unsymmetrical bis(azolium) salts, unsymmetrical CCC—NHC metal complexes, and methods of forming the same. The unsymmetrical bis(azolium) salts include a central aryl ring that is substituted with two heterocyclic rings in an ortho, meta, or para fashion. The unsymmetrical CCC—NHC metal complexes include metalated unsymmetrical bis(azolium) salts. The method of forming the unsymmetrical CCC—NHC metal complexes includes reacting a dihalogenated benzene with a first azole to form a mono(azole)benzene, reacting the mono(azole)benzene with a second azole to form an unsymmetrical bis(azole)benzene, alkylating the unsymmetrical bis(azole)benzene to form an unsymmetrical bis(azolium) salt, and metalating the unsymmetrical bis(azolium) salt to form the unsymmetrical CCC—NHC metal complex. Also provided are a bis-ligated CCC—NHC metal complex and an unsymmetrical bimetallic complex.
FILED Monday, February 22, 2021
APPL NO 17/182199
CURRENT CPC
Heterocyclic Compounds
C07D 403/10 (20130101) Original (OR) Class

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 15/02 (20130101)
C07F 15/0086 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 20210177932 Song et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Moon K. Song (Washington, District of Columbia);  David S. Bischoff (Washington, District of Columbia);  Dean T. Yamaguchi (Washington, District of Columbia);  Koichi Uyemura (Washington, District of Columbia);  Ram Pyare Singh (Washington, District of Columbia)
ABSTRACT Disclosed herein are compositions and methods for the prevention and treatment of immune deficiency and inflammation using cyclic histidyl-proline plus zinc (Cyclo-Z). Disclosed herein are compositions that can be used to treat immune disorders and inflammation.
FILED Sunday, November 11, 2018
APPL NO 16/771427
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/48 (20130101)
A61K 9/0053 (20130101)
A61K 33/30 (20130101)
A61K 38/12 (20130101) Original (OR) Class
A61K 47/547 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180136 Delgado-Escueta et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Marco Tulio Medina-Hernandez (Los Angeles, California);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California);  RIKEN (SAITAMA, Japan);  INSTITUTO NACIONAL DE NEUROLOGIA Y NEUROCIRUGIA MANUEL VELASCO SUAREZ (DELEGACION TLALPAN, Mexico);  U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (WASHINGTON, District of Columbia)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California);  RIKEN (SAITAMA, Japan);  INSTITUTO NACIONAL DE NEUROLOGIA Y NEUROCIRUGIA MANUEL VELASCO SUAREZ (DELEGACION TLALPAN, Mexico);  U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (WASHINGTON, District of Columbia)
INVENTOR(S) Antonio V. Delgado-Escueta (MALIBU, California);  Kazuhiro Yamakawa (Saitama, Japan);  Toshimitsu Suzuki (SAITAMA, Japan);  Marco Tulio Medina-Hernandez (Tegucigalpa, Honduras);  Maria Elisa Alonso Vilatela (Delegacion Coyoacan, Mexico)
ABSTRACT Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1, EFHC1 agonists, or EFHC1 analogs are provided. Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1a, EFHC1a agonists, or EFHC1a analogs are provided.
FILED Monday, February 08, 2021
APPL NO 17/248798
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 2600/118 (20130101)
C12Q 2600/156 (20130101)
C12Q 2600/172 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

MITRE Corporation (MITRE) 

US 20210177327 RIESER et al.
FUNDED BY
MITRE Corporation (MITRE)
APPLICANT(S) The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S) The MITRE Corporation (McLean, Virginia)
INVENTOR(S) Cj RIESER (Charlottesville, Virginia);  Robyn J. WADE (Hamilton, Virginia);  David Michael SLATER (Herndon, Virginia);  Steven GUAN (Fairfax, Virginia);  Haoyang Haven LIU (Burke, Virginia)
ABSTRACT Described are methods and systems to provide an adaptive cognitive analytics platform to a user such that the user's data remains secure while enabling functionality adaptive to the user's needs. In some embodiments, a cognitive analytics application can be installed on the user's mobile device to analyze a plurality of data streams generated by sensors worn by the user. The cognitive analytics application is configured to allow the user to select and download one or more analytics programs from a plurality of vetted analytics programs depending on the user's desired functionality. The cognitive analytics application can be configured to determine the types of analytics program usable by the user based on the data streams available at the user's mobile device. To secure user data and protect the user's data privacy, the cognitive analytics application can prevent the plurality of analytics programs from transmitting monitored physiological data.
FILED Friday, November 13, 2020
APPL NO 17/098164
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0006 (20130101)
A61B 5/165 (20130101) Original (OR) Class
A61B 5/02405 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 50/20 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184416 MARLOW
FUNDED BY
MITRE Corporation (MITRE)
APPLICANT(S) The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S)
INVENTOR(S) Bonnie L. MARLOW (Ashburn, Virginia)
ABSTRACT A degenerate four-wave mixing (DFWM) squeezed light apparatus includes one or more pump beams, a probe beam, a vapor cell, a repump beam, and a detector. The one or more pump beams includes an input power of no greater than about 150 mW. The vapor cell includes an atomic vapor configured to interact with overlapped pump and probe beams to generate an amplified probe beam and a conjugate beam. The repump beam is configured to optically pump the atomic vapor to a ground state and decrease atomic decoherence of the atomic vapor. The detector is configured to measure squeezing due to quantum correlations between the amplified probe beam and the conjugate beam. The one or more pump beams, the probe beam, and the repump beam are configured to generate two-mode squeezed light by DFWM with squeezing of at least 3 dB below shot noise.
FILED Thursday, December 10, 2020
APPL NO 17/117331
CURRENT CPC
Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/0057 (20130101) Original (OR) Class
H01S 3/169 (20130101)
H01S 3/227 (20130101)
H01S 3/0941 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 20210178339 Glover
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Thomas Grant Glover (Spanish Fort, Alabama)
ASSIGNEE(S)
INVENTOR(S) Thomas Grant Glover (Spanish Fort, Alabama)
ABSTRACT A method of encapsulating an engineered pellet in a porous membrane is disclosed. The method includes the steps of: (i) dissolving a membrane solute in a membrane solvent to produce a membrane solution; (ii) applying the membrane solution to a pellet to form a pellet encapsulated with the membrane solution; (iii) subjecting the membrane solution that encapsulates the pellet to a phase inversion and; (iv) drying the pellet to form a porous membrane encapsulated pellet. A porous membrane encapsulated pellet is also described.
FILED Tuesday, December 15, 2020
APPL NO 17/121974
CURRENT CPC
Separation
B01D 53/08 (20130101)
B01D 53/1475 (20130101)
B01D 67/0002 (20130101)
B01D 69/141 (20130101) Original (OR) Class
B01D 2325/02 (20130101)
B01D 2325/14 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/226 (20130101)
B01J 20/262 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 20210178436 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Wareham, Massachusetts)
ASSIGNEE(S) Loci Controls, Inc. (Wareham, Massachusetts)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Joseph G. Michels (New York, New York);  Melinda Sims (Seattle, Washington)
ABSTRACT A control system for controlling extraction of landfill gas from a landfill via a gas extraction system comprising well piping, the landfill gas having a first temperature when extracted, the control system comprising: a gas composition chamber coupled to the well piping and comprising at least one sensor configured to measure one or more characteristics of a landfill gas sample in the gas composition chamber; a temperature control mechanism configured to heat the landfill gas sample in the gas composition chamber to a second temperature at least a threshold amount greater than the first temperature; and a controller configured to control the at least one sensor to measure the one or more characteristics of the landfill gas sample in the gas composition chamber when a temperature of the landfill gas sample in the gas composition chamber is at least the threshold amount greater than the first temperature.
FILED Thursday, February 04, 2021
APPL NO 17/167539
CURRENT CPC
Disposal of Solid Waste
B09B 1/00 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/0016 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Government Rights Acknowledged 

US 20210180516 Rambo
FUNDED BY
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Jeffrey Douglas Rambo (Mason, Ohio)
ABSTRACT A heat management system for a turbomachine may include a first heat exchanger configured and arranged to receive a first fluid stream from a first duct, a second heat exchanger configured and arranged to receive the first fluid stream after discharging from the first heat exchanger, and a second duct fluidly communicating with the first duct between the first heat exchanger and the second heat exchanger to introduce a second fluid stream from the second duct to the first duct. A method of cooling fluid streams may include directing a first fluid stream from a first duct across or through a first heat exchanger, directing the first fluid stream across or through a second heat exchanger after discharging from the first heat exchanger, and directing a second fluid stream from a second duct to the first duct, with the second duct fluidly communicating with the first duct between the first heat exchanger and the second heat exchanger.
FILED Monday, February 08, 2021
APPL NO 17/170029
CURRENT CPC
Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants
F02C 7/141 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2260/232 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210180651 Witlicki et al.
FUNDED BY
APPLICANT(S) United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Russell B. Witlicki (Wethersfield, Connecticut);  Todd A. Davis (Tolland, Connecticut);  Christopher M. Valva (Manchester, Connecticut);  David C. Kiely (Manchester, Connecticut);  Andrew Newton (Ellington, Connecticut)
ABSTRACT A gas turbine engine component includes a bearing configured to support a shaft for rotation about an axis, wherein the bearing includes an outer race and an inner race, and a bearing housing spaced radially outwardly of the outer race. A curved beam centering spring is positioned between the outer race and the bearing housing. A cylindrical wall is radially outward of the bearing housing and engages the outer race and the bearing housing.
FILED Wednesday, December 11, 2019
APPL NO 16/710667
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 25/16 (20130101)

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2220/32 (20130101)
F05D 2240/52 (20130101)

Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings
F16C 19/10 (20130101)
F16C 35/063 (20130101) Original (OR) Class
F16C 2360/23 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210184899 ROBINSON
FUNDED BY
APPLICANT(S) Rampart Communications, Inc. (Annapolis, Maryland)
ASSIGNEE(S) Rampart Communications, Inc. (Annapolis, Maryland)
INVENTOR(S) Matthew Brandon ROBINSON (Crownsville, Maryland)
ABSTRACT A system includes first and second sets of communication devices. A processor coupled to the first set of communication devices produces a first encoded vector and transmits the first encoded vector to the second set of communication devices via a communication channel that applies a channel transformation to the first encoded vector during transmission. A processor coupled to the second set of communication devices receives the transformed signal, detects an effective channel thereof, and identifies left and right singular vectors of the effective channel. A precoding matrix is selected from a codebook of unitary matrices based on a message, and a second encoded vector is produced based on a second known vector, the precoding matrix, a complex conjugate of the left singular vectors, and the right singular vectors. The second encoded vector is sent to the first set of communication devices for identification of the message.
FILED Thursday, January 28, 2021
APPL NO 17/161118
CURRENT CPC
Transmission
H04B 7/0413 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 25/0391 (20130101) Original (OR) Class
H04L 27/2602 (20130101)

Wireless Communication Networks
H04W 12/03 (20210101)
VIEW PATENT @ USPTO:  Full Text   PDF 

How To Use This Page 

THE FEDINVENT PATENT APPLICATION DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Thursday, June 17, 2021.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
     National Institutes of Health (NIH)
         National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
     Defense Advanced Research Projects Agency (DARPA)
         Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract is presented as it appears on the patent.

FILED
The date the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

  • A61B 1/149 (20130101)
  • A61B 1/71 (20130101)
  • A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

info@wayfinder.digital