FedInvent Patent Applications

Patent Application Details for Thursday, June 24, 2021 

This page was updated on Saturday, July 17, 2021 at 01:40 AM GMT

Department of Health and Human Services (HHS) 

US 20210185990 Fahrenkrug et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Recombinetics, Inc. (Eagan, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Scott C. Fahrenkrug (Minneapolis, Minnesota);  Daniel F. Carlson (Woodbury, Minnesota)
ABSTRACT Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature. One embodiment includes compositions and methods for making livestock with a polled allele, including migrating a polled allele into a bovine species without changing other genes or chromosomal portions.
FILED Thursday, December 10, 2020
APPL NO 17/118064
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0275 (20130101)
A01K 67/0276 (20130101) Original (OR) Class
A01K 2227/40 (20130101)
A01K 2227/101 (20130101)
A01K 2227/102 (20130101)
A01K 2227/103 (20130101)
A01K 2227/107 (20130101)
A01K 2227/108 (20130101)

Peptides
C07K 14/47 (20130101)
C07K 14/715 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101)
C12N 15/90 (20130101)
C12N 15/902 (20130101)
C12N 15/907 (20130101)
C12N 15/8509 (20130101)
C12N 15/8771 (20130101)
C12N 15/8778 (20130101)
C12N 2750/14143 (20130101)
C12N 2800/30 (20130101)
C12N 2800/90 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186010 Bassler et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S) The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S) Bonnie L. Bassler (Princeton, None);  Howard A. Stone (Princeton, None);  Min Young Kim (Seoul, South Korea);  Thomas William Muir (Princeton, New Jersey);  Aishan Zhao (Princeton, New Jersey)
ABSTRACT The invention relates to compositions comprising Quorum-Sensing (QS) modulating molecules attached to a surface via a linker. This QS modulator attached surface can then be used to modulate QS, biofilm production, biofilm streamer production and/or virulence factor production. The length of the linker that attaches the QS modulating molecule to the surface as well as the surface coverage density impact QS modulation on surfaces. These QS modulator attached surfaces can be used to treat areas known to contain human pathogens notorious for causing hospital-acquired infections as well as fatal infections that occur outside of health care settings. Other surfaces that can be coated according to embodiments of the invention include abiotic materials, such as intravenous catheters, implants, medical devices, and cooling towers. Preferred microorganisms that can be treated with the compositions of the invention include, but are not limited to S. aureus and/or P. aeruginosa. The QS modulator attached surface also demonstrates exceptional stability.
FILED Saturday, October 17, 2020
APPL NO 17/073326
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 25/08 (20130101)
A01N 25/10 (20130101) Original (OR) Class
A01N 35/04 (20130101)
A01N 43/16 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/18 (20130101)
C12Q 1/025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186353 Ernst et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) THE QUEEN'S MEDICAL CENTER (Honolulu, Hawaii);  THE UNIVERSITY OF HAWAII (Honolulu, Hawaii);  THE MEDICAL COLLEGE OF WISCONSIN, INC. (Milwaukee, Wisconsin);  UWM RESEARCH FOUNDATION, INC. (Milwaukee, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Thomas Michael Ernst (Honolulu, Hawaii);  Thomas Edmund Prieto (Grafton, Wisconsin);  Brian Stewart Randall Armstrong (Shorewood, Wisconsin)
ABSTRACT This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P). This invention also provides for internal calibration and for co-registration over time of the scanner's and tracking system's reference frames to compensate for drift and other inaccuracies that may arise over time.
FILED Monday, December 14, 2020
APPL NO 17/121585
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/055 (20130101) Original (OR) Class
A61B 5/0077 (20130101)
A61B 5/721 (20130101)
A61B 5/1127 (20130101)
A61B 5/1128 (20130101)
A61B 5/7292 (20130101)
A61B 6/0492 (20130101)
A61B 6/547 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/28 (20130101)
G01R 33/56509 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00624 (20130101)
G06K 2009/3291 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 7/70 (20170101)

Pictorial Communication, e.g Television
H04N 7/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186372 BaTES
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of Vermont and State Agricultural College (Burlington, Vermont)
ASSIGNEE(S)
INVENTOR(S) Jason T BaTES (South Burlington, Vermont)
ABSTRACT A novel method and apparatus for analyzing multi-breath nitrogen washout (MBNW) data from a lung is provided. The novel method includes fitting multi-compartment lung model, having five free parameters, to an exhaled nitrogen concentration profile over the entire duration of expiration for each breath from the lung. The five free parameters include 1) functional residual capacity, 2) dead space volume, 3) the standard deviation of the rate of change of fractional contribution to expired flow from each lung region as a function of lung volume, 4) the intrinsic slope of Phase-Ill due to acinar asymmetry, and 5) the coefficient of variation of regional specific ventilation.
FILED Thursday, October 25, 2018
APPL NO 16/757481
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/087 (20130101)
A61B 5/091 (20130101) Original (OR) Class
A61B 5/097 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186380 Liberman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Massachusetts Eye and Ear Infirmary (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) M. Charles Liberman (Milton, Massachusetts);  Stephane Maison (Boston, Massachusetts)
ABSTRACT Non-invasive methods of detecting hidden hearing loss (cochlear synaptopathy) based on detection of an abnormal ratio of Summating Potential (SP)/Action Potential (AP) (SP/AP) Ratios.
FILED Friday, January 20, 2017
APPL NO 16/071372
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/126 (20130101) Original (OR) Class
A61B 5/4836 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186405 Davids et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Mathias Davids (Cambridge, Massachusetts);  Lawrence L. Wald (Cambridge, Massachusetts);  Bastien Guerin (Cambridge, Massachusetts)
ABSTRACT A method for assessing peripheral nerve stimulation (PNS) for a coil geometry includes retrieving a PNS Huygens' P-matrix for a body model. The PNS Huygens' P-matrix is defined on a Huygens' surface enclosing the body model. The method further includes generating a coil specific PNS P-matrix for the coil geometry based on at least the PNS Huygens' P-matrix for the body model, determining at least one PNS threshold for the coil geometry based on the coil specific PNS P-matrix, and storing the at least one PNS threshold in a storage device.
FILED Thursday, December 10, 2020
APPL NO 17/118155
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/311 (20210101) Original (OR) Class
A61B 5/388 (20210101)
A61B 5/0515 (20130101)
A61B 2560/04 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/0029 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186411 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Lihong Wang (Pasadena, California);  Konstantin Maslov (Pasadena, California);  Methodius Tuuli (Indianapolis, Indiana);  Molly Stout (St. Louis, Missouri);  George Macones (St. Louis, Missouri);  Chiye Li (St. Louis, Missouri);  Junhui Shi (Pasadena, California);  Yuan Qu (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri);  California Institute of Technology (Pasadena, California)
INVENTOR(S) Lihong Wang (Pasadena, California);  Konstantin Maslov (Pasadena, California);  Methodius Tuuli (Indianapolis, Indiana);  Molly Stout (St. Louis, Missouri);  George Macones (St. Louis, Missouri);  Chiye Li (St. Louis, Missouri);  Junhui Shi (Pasadena, California);  Yuan Qu (St. Louis, Missouri)
ABSTRACT The present disclosure describes a fast-scanning optical-resolution photoacoustic (fsOR-PAE) endoscope for imaging vasculature within tissues in vivo that includes an ultrasonic transducer and a scanning mirror within a lumen of an elongate casing. The scanning mirror is configured to direct the laser pulses from the pulsed laser source to a focal spot outside the casing in a scanning pattern via an imaging window formed in the casing. The scanning mirror is further configured to direct a plurality of photoacoustic signals from the focal spot to the ultrasonic transducer via the imaging window.
FILED Tuesday, December 22, 2020
APPL NO 17/130021
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/07 (20130101)
A61B 1/00172 (20130101)
A61B 1/303 (20130101)
A61B 5/0095 (20130101)
A61B 5/435 (20130101) Original (OR) Class
A61B 5/02007 (20130101)
A61B 2562/028 (20130101)

Optical Elements, Systems, or Apparatus
G02B 26/105 (20130101)
G02B 26/0833 (20130101)

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/17 (20130101)
G02F 2203/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186426 Raju et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Science Foundation (NSF)
APPLICANT(S) University of Washington (Seattle, Washington);  Seattle Children's Hospital (DBA Seattle Children's Research Institute) (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington);  Seattle Children's Hospital (DBA Seattle Children's Research Institute) (Seattle, Washington)
INVENTOR(S) Sharat Raju (Seattle, Washington);  Shyamnath Gollakota (Seattle, Washington);  Justin Chan (Seattle, Washington);  Randall Bly (Seattle, Washington);  Rajalakshmi Nandakumar (Seattle, Washington)
ABSTRACT Examples of systems and methods described herein may estimate a state of the ear canal of a patient utilizing a smart phone by characterizing acoustic waveforms reflected off the patient's eardrum. Examples may include an acoustic focusing apparatus that may be connected to a smart phone to provide acoustic signals to and receive reflected signals from an ear canal.
FILED Friday, September 06, 2019
APPL NO 17/274137
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/742 (20130101)
A61B 5/6817 (20130101) Original (OR) Class
A61B 5/6898 (20130101)
A61B 5/7264 (20130101)
A61B 2560/0223 (20130101)
A61B 2562/12 (20130101)

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding
G10L 25/51 (20130101)

Telephonic Communication
H04M 1/035 (20130101)
H04M 1/2155 (20130101)

Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 1/08 (20130101)
H04R 1/025 (20130101)
H04R 1/345 (20130101)
H04R 2499/11 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186801 Thomas et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) UNIVERSITY OF MIAMI (Miami, Florida)
ASSIGNEE(S)
INVENTOR(S) Christine Thomas (Miami, Florida);  Jorge Bohorquez (Doral, Florida);  Khema Sharma (Miami, Florida);  Bradley Deforest (Pembroke Pines, Florida)
ABSTRACT A personalized wearable device can detect muscle contractions, such as spasms, and provide vibrational energy that treats these muscle contractions.
FILED Thursday, September 05, 2019
APPL NO 17/273494
CURRENT CPC
Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body
A61H 23/02 (20130101) Original (OR) Class
A61H 2201/0157 (20130101)
A61H 2201/165 (20130101)
A61H 2201/5007 (20130101)
A61H 2205/10 (20130101)
A61H 2230/605 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186831 Cheng et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Ke Cheng (Raleigh, North Carolina);  Shiqi Hu (Raleigh, North Carolina)
ABSTRACT The present disclosure provides compositions and methods relating to the use of exosomes derived from human dermal fibroblasts (HDFs). In particular, the present disclosure provides novel compositions and methods for generating and maintaining exosomes derived from HDF spheroids, as well as compositions and methods for delivering the exosomes to a subject for various therapeutic purposes, such as the treatment of skin conditions.
FILED Friday, December 18, 2020
APPL NO 17/126572
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 8/14 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0062 (20130101)
C12N 5/0656 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186888 SINGH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Wake Forest University Health Sciences (Winston-Salem, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Ravi SINGH (Gastonia, North Carolina);  Jessica SWANNER (Winston-Salem, North Carolina);  Cale FAHRENHOLTZ (Winston-Salem, North Carolina)
ABSTRACT In one aspect, methods of treating cancer are disclosed. A method described herein, in some embodiments, comprises quantifying ZEB1 expression in a cancerous cell population and administering silver nanoparticles to the cancerous population if the quantified ZEB1 expression meets or exceeds a ZEB1 expression threshold. In some embodiments, the quantified ZEB1 expression is compared to a ZEB1 expression threshold above which a cancerous cell population response to silver nanoparticles.
FILED Tuesday, June 12, 2018
APPL NO 16/622128
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5115 (20130101) Original (OR) Class
A61K 9/5138 (20130101)
A61K 31/4436 (20130101)
A61K 33/38 (20130101)
A61K 45/06 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57484 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186921 Martinez-Lemus et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Curators Of The University Of Missouri (Columbia, Missouri)
ASSIGNEE(S)
INVENTOR(S) Luis A. Martinez-Lemus (Columbia, Missouri);  Christopher A. Foote (Columbia, Missouri);  Jaume Padilla (Columbia, Missouri)
ABSTRACT Disclosed are methods for ameliorating glycocalyx damage by administering a neuraminidase inhibitor. Also disclosed are methods for treating endothelial dysfunction and for improving flow mediated dilation.
FILED Wednesday, October 10, 2018
APPL NO 16/754814
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/196 (20130101)
A61K 31/215 (20130101)
A61K 31/351 (20130101) Original (OR) Class
A61K 31/445 (20130101)
A61K 38/47 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186936 Prossnitz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Eric R. Prossnitz (Albuquerque, New Mexico);  Geetanjali Sharma (Albuquerque, New Mexico);  Matthias Barton (Zurich, Switzerland);  Matthias R. Meyer (Stallikon, Switzerland)
ABSTRACT The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).
FILED Monday, March 01, 2021
APPL NO 17/188384
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/16 (20130101)
A61K 31/435 (20130101)
A61K 31/436 (20130101) Original (OR) Class
A61K 31/437 (20130101)
A61K 31/4355 (20130101)
A61K 31/7088 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186963 Wipf et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S) Peter Wipf (Pittsburgh, Pennsylvania);  James K. Johnson (Silver Spring, Maryland);  Erin M. Skoda (Silver Spring, Maryland);  Joel B. Nelson (Pittsburgh, Pennsylvania);  Zhou Wang (Pittsburgh, Pennsylvania);  Serene Tai (Pittsburgh, Pennsylvania);  Keita Takubo (Pittsburgh, Pennsylvania);  John Milligan (Philadelphia, Pennsylvania)
ABSTRACT A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I:
R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(═O), S(═O)(═O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is —C(═O)—, —S(═O)(═O)—, or —N(H)C(═O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.
FILED Wednesday, November 04, 2020
APPL NO 17/089519
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0053 (20130101)
A61K 31/47 (20130101)
A61K 31/122 (20130101)
A61K 31/167 (20130101)
A61K 31/401 (20130101)
A61K 31/407 (20130101)
A61K 31/497 (20130101)
A61K 31/504 (20130101) Original (OR) Class
A61K 31/4166 (20130101)
A61K 31/4439 (20130101)
A61K 31/4985 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186964 D'Andrea et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Alan D'Andrea (Winchester, Massachusetts);  Kah Suan Lim (Boston, Massachusetts)
ABSTRACT The disclosure relates to methods for treating cancers (e.g., cancers having a BRCA1 and/or BRCA2 mutation(s)) by administering to the subject an effective amount of a ubiquitin-specific protease 1 (USP1) inhibitor.
FILED Monday, October 15, 2018
APPL NO 16/755686
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/423 (20130101)
A61K 31/454 (20130101)
A61K 31/506 (20130101) Original (OR) Class
A61K 31/713 (20130101)
A61K 31/4439 (20130101)
A61K 38/45 (20130101)
A61K 38/1761 (20130101)
A61K 39/3955 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/40 (20130101)
C07K 2317/24 (20130101)
C07K 2317/54 (20130101)
C07K 2317/55 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1137 (20130101)
C12N 2310/11 (20130101)
C12N 2310/14 (20130101)

Enzymes
C12Y 203/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186972 Rudloff et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland);  University of Kansas (Lawrence, Kansas);  Northwestern University (Evanston, Illinois)
ASSIGNEE(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland);  University of Kansas (Lawrence, Kansas);  Northwestern University (Evanston, Illinois)
INVENTOR(S) Udo Rudloff (Bethesda, Maryland);  Serguei Kozlov (Bethesda, Maryland);  Juan Jose Marugan (Gaithersburg, Maryland);  Sui Huang (Chicago, Illinois);  Samarjit Patnaik (Gaithersburg, Maryland);  John C. Braisted (Boyds, Maryland);  Noel T. Southall (Potomac, Maryland);  Marc Ferrer (Potomac, Maryland);  Christopher Dextras (Frederick, Maryland);  John Haslam (Lawrence, Kansas);  Michael Baltezor (Shawnee, Kansas)
ABSTRACT Disclosed are pharmaceutical formulations comprising a compound of formula (I): in which R1, R2, R3, and R4 are as described herein, or a pharmaceutically acceptable salt thereof. Also provided are methods for treating pancreatic adenocarcinoma comprising administration of a compound of formula (I), or a pharmaceutically acceptable salt thereof, and methods of detecting the change in expression levels of one or both of FoxA1 and FoxO6 in a pancreatic adenocarcinoma tumor sample from a mammal, wherein the mammal has been administered a compound of formula (I), or a pharmaceutically acceptable salt thereof.
FILED Wednesday, May 15, 2019
APPL NO 17/055256
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/519 (20130101) Original (OR) Class
A61K 31/7068 (20130101)
A61K 45/06 (20130101)
A61K 47/12 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186979 Roush et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S)
INVENTOR(S) William R. Roush (Jupiter, Florida);  Derek R. Duckett (Jupiter, Florida);  Andrii Monastyrskyi (Jupiter, Florida)
ABSTRACT The invention provides compounds and methods of inhibiting a cyclin-dependent kinase, comprising contacting the cyclin-dependent kinase and an effective amount or concentration of a compound of formula (I) wherein variables are as defined herein. Compounds of formula (I) can be highly selective inhibitors of cyclin-dependent kinases such as CDK12/13, relative to other kinases such as casein kinases, such as CK1δ/ε. Compounds can be used in treatment of cancers, such as breast cancer, brain cancer and ovarian cancer.
FILED Tuesday, May 07, 2019
APPL NO 17/053652
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/5377 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186993 Altieri et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Dario C. Altieri (Philadelphia, Pennsylvania);  Jagadish C. Ghosh (Aldan, Pennsylvania)
ABSTRACT Pharmaceutical compositions for the treatment of cancer are provided. In one embodiment, the composition comprises Gamitrinib and a PI3K inhibitor selected from PX-866, AZD6482, LY294002, BEZ235, GSK458, GDC0941, ZSTK474, BKM120 and GSK2636771B. Methods of treating cancer are also provided.
FILED Friday, August 07, 2020
APPL NO 16/987974
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/66 (20130101)
A61K 31/501 (20130101)
A61K 31/519 (20130101)
A61K 31/585 (20130101)
A61K 31/665 (20130101) Original (OR) Class
A61K 31/4745 (20130101)
A61K 31/5377 (20130101)
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187013 Counter et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) DUKE UNIVERSITY (Durham, North Carolina)
ASSIGNEE(S) DUKE UNIVERSITY (Durham, North Carolina)
INVENTOR(S) Chris M. Counter (Durham, North Carolina);  Donita C. Brady (Durham, North Carolina);  Michelle L. Turski (San Francisco, California);  Dennis J. Thiele (Chapel Hill, North Carolina)
ABSTRACT The present disclosure provides methods of treating and/or preventing cancer in a subject comprising administering to the subject a copper-reduced diet by itself or as a supplement along with a regular diet to create a copper-reduced melieu, maintain a reduced-copper melieu, or both, thereby treating and/or preventing the development of the cancer. Methods also comprise further adding a copper chelator, MEK inhibitor, or combinations thereof.
FILED Friday, January 08, 2021
APPL NO 17/144967
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/18 (20130101)
A61K 31/095 (20130101)
A61K 31/132 (20130101)
A61K 31/198 (20130101)
A61K 31/275 (20130101)
A61K 31/416 (20130101)
A61K 31/519 (20130101)
A61K 31/4523 (20130101)
A61K 31/4745 (20130101)
A61K 33/24 (20130101) Original (OR) Class
A61K 33/30 (20130101)
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187023 Rabinowitz
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Joshua D. Rabinowitz (Princeton, New Jersey)
ABSTRACT The present invention provides, in some embodiments, methods of promoting an immune response in a subject in need thereof, comprising administering to a subject a population of immune cells that express an exogenous enzyme that facilitates immune cell function in a nutrient-poor environment. Other embodiments of the invention include methods of promoting an immune response to a tumor in a subject in need thereof, comprising administering to the subject an effective amount of an agent that provides a one-carbon unit (e.g., formate) and an agent that promotes an anti-tumor response, and methods of promoting an immune response to a tumor in a subject in need thereof, comprising administering to a subject an effective amount of an agent that inhibits consumption of metabolic fuels by tumor cells. The invention also provides, in other embodiments, compositions comprising an ex vivo population of immune cells expressing an exogenous enzyme that enhances immune cell function in nutrient poor environments, and compositions comprising a nucleic acid expression construct encoding an inhibitor of glucose metabolism, and a pharmaceutically acceptable carrier or excipient.
FILED Wednesday, June 27, 2018
APPL NO 16/621660
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class

Peptides
C07K 16/2818 (20130101)
C07K 16/3084 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
C12N 15/1138 (20130101)
C12N 2310/14 (20130101)
C12N 2500/02 (20130101)
C12N 2501/71 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187038 KAUSHAL
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of Maryland, Baltimore (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Sunjay KAUSHAL (Ruxton, Maryland)
ABSTRACT Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof.
FILED Wednesday, March 03, 2021
APPL NO 17/191526
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/34 (20130101) Original (OR) Class
A61K 38/19 (20130101)
A61K 38/195 (20130101)
A61K 38/1833 (20130101)
A61K 38/1866 (20130101)
A61K 38/1891 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187042 Liu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Meharry Medical College (Nashville, Tennessee)
ASSIGNEE(S) Meharry Medical College (Nashville, Tennessee)
INVENTOR(S) Bindong Liu (Brentwood, Tennessee);  Qiujia Shao (Brentwood, Tennessee)
ABSTRACT Compositions of glycan strands and oligosaccharides derived from gram-positive bacteria and methods of use thereof are provided. The disclosed compositions have inhibitory activity toward both early and late stages of viral infection and transmission. The disclosed compositions may be used to treat and/or prevent infection and transmission of viruses, such as HIV, to upregulate one or both of AG3 and MX2, to enhance immune function, and/or to inhibit replication of a virus.
FILED Thursday, May 23, 2019
APPL NO 17/057599
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0014 (20130101)
A61K 9/0019 (20130101)
A61K 31/34 (20130101)
A61K 31/52 (20130101)
A61K 31/427 (20130101)
A61K 31/439 (20130101)
A61K 31/513 (20130101)
A61K 31/675 (20130101)
A61K 31/702 (20130101)
A61K 31/715 (20130101)
A61K 31/4418 (20130101)
A61K 31/5377 (20130101)
A61K 31/7072 (20130101)
A61K 35/74 (20130101) Original (OR) Class
A61K 38/162 (20130101)
A61K 38/212 (20130101)
A61K 45/06 (20130101)
A61K 47/60 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/18 (20180101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 3/06 (20130101)

Polysaccharides; Derivatives Thereof
C08B 37/0003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187056 Szeto et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Aging (NIA)
APPLICANT(S) Cornell University (Ithaca, New York);  University of Washington (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Hazel H. Szeto (New York, New York);  Peter S. Rabinovitch (Shoreline, Washington);  Dao-Fu Dai (Seattle, Washington)
ABSTRACT The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.
FILED Thursday, October 29, 2020
APPL NO 17/084046
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 38/07 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/00 (20180101)

Peptides
C07K 5/0817 (20130101)
C07K 5/1016 (20130101)
C07K 5/1019 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187069 DiAntonio et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Aaron DiAntonio (St. Louis, Missouri);  Jeffrey D. Milbrandt (St. Louis, Missouri);  Daniel Summers (St. Louis, Missouri);  Stefanie Geisler (St. Louis, Missouri);  Xianrong Mao (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Aaron DiAntonio (St. Louis, Missouri);  Jeffrey D. Milbrandt (St. Louis, Missouri);  Daniel Summers (St. Louis, Missouri);  Stefanie Geisler (St. Louis, Missouri);  Xianrong Mao (St. Louis, Missouri)
ABSTRACT The present invention provides compositions useful as inhibitors of SARM1 activity, pharmaceutical compositions thereof, and methods of using the same. The present invention provides dominant negative SARM1 molecules useful for treating a neurodegenerative or neurological disease or disorder, pharmaceutical compositions thereof, and methods of using the same.
FILED Thursday, October 18, 2018
APPL NO 16/757254
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/76 (20130101)
A61K 38/1709 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187076 Waller et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Emory University (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Giacomo Waller (Atlanta, Georgia);  Yiwen Li (Atlanta, Georgia);  Edmund Waller (Atlanta, Georgia)
ABSTRACT In certain embodiments, this disclosure relates to VIP and VIP agonists, optionally conjugated to nanoparticles, for use in methods of treating inflammatory T cell-mediated diseases or conditions, e.g., treating or preventing GvHD. In certain embodiments, this disclosure relates to methods of pulmonary administration of VIP and VIP agonists, optionally conjugated to nanoparticles. In certain embodiments, this disclosure contemplates nanoparticles disclosed herein.
FILED Tuesday, April 23, 2019
APPL NO 17/050348
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0075 (20130101)
A61K 9/124 (20130101)
A61K 38/26 (20130101) Original (OR) Class
A61K 47/24 (20130101)
A61K 47/6935 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187087 McNeel et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Douglas G. McNeel (Madison, Wisconsin);  Viswa T. Colluru (Madison, Wisconsin)
ABSTRACT It is disclosed herein that B cells, not dendritic cells or myeloid-derived populations, are primary human antigen presenting cells for plasmid DNA. Based on this finding, improved methods and compositions for administering DNA vaccines are disclosed. Specifically, DNA vaccines are co-administered with a B cell targeting agent, B-cell recruiting agent, or a monocyte or dendritic cell recruiting agent. To increase the immunogenicity of the DNA vaccines, the B cell targeting agent or B cell recruiting agent is administered at the same location where the DNA vaccine is administered. In contrast, the monocyte or dendritic cell recruiting agent can be administered in a different location, in order to recruit cells competing with the B cells for DNA uptake away from the location where the DNA vaccine is administered.
FILED Wednesday, March 03, 2021
APPL NO 17/191378
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/0011 (20130101) Original (OR) Class
A61K 39/001106 (20180801)
A61K 39/001184 (20180801)
A61K 39/001193 (20180801)
A61K 39/001194 (20180801)
A61K 2039/53 (20130101)
A61K 2039/60 (20130101)
A61K 2039/555 (20130101)
A61K 2039/572 (20130101)
A61K 2039/585 (20130101)
A61K 2039/6031 (20130101)
A61K 2039/6056 (20130101)
A61K 2039/55522 (20130101)
A61K 2039/55555 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187133 Namavari et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Mohammad Namavari (Palo Alto, California);  Sanjiv S. GAMBHIR (Portola Valley, California);  Beverly S. Mitchell (Menlo Park, California)
ABSTRACT Embodiments of the present disclosure provide for compounds and methods of making compounds such as those shown in FIG. 1.1A and 1.1B having formula 2, 3, 4, 5, 11, and 12 and formula 2′, 4′, and 11′, as well as uses for the compounds for imaging, and the like.
FILED Thursday, February 25, 2021
APPL NO 17/185502
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 51/0491 (20130101) Original (OR) Class

General Methods of Organic Chemistry; Apparatus Therefor
C07B 59/005 (20130101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 19/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187162 Wagner et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of Vermont and State Agricultural College (Burlington, Vermont)
ASSIGNEE(S)
INVENTOR(S) Darcy Wagner (Burlington, Vermont);  Daniel J. Weiss (Essex Junction, Vermont);  Nicholas Bonenfant (Essex Junction, Vermont);  Rachael Oldinski (Colchester, Vermont);  Spencer Fenn (Rutland, Vermont)
ABSTRACT The present invention provides systems and methods for the decellularization and recellularization of tissue segments. In certain instances the invention comprises coating or sealing decellularized tissue segments with a cross-linked alginate hydrogel. The present invention also provides a decellularization kit, which may be used to generate decellularized tissue segments for high throughput studies. Also included are compositions and methods of tissue sealants comprising methacrylated alginate.
FILED Wednesday, January 13, 2021
APPL NO 17/148139
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 17/00 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 24/08 (20130101)
A61L 24/0031 (20130101)
A61L 24/046 (20130101)
A61L 27/34 (20130101)
A61L 27/38 (20130101)
A61L 27/52 (20130101)
A61L 27/54 (20130101)
A61L 27/3604 (20130101) Original (OR) Class
A61L 27/3687 (20130101)
A61L 2430/40 (20130101)

Polysaccharides; Derivatives Thereof
C08B 37/0084 (20130101)

Compositions of Macromolecular Compounds
C08L 5/04 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 105/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187165 VUKELIC et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Sinisa VUKELIC (New York, New York);  Gerard A. ATESHIAN (New York, New York);  Chao WANG (New York, New York);  Krista M. DURNEY (Upton, New York)
ABSTRACT Treatment systems and methods are disclosed that may be used to strengthen cartilage. The disclosed subject matter includes description of this advantage and associated experimental results. The systems and methods employ ultrafast laser-based treatment to induce crosslinks into the collagen network of the tissue media without the addition of a chemical agent. The system and related methods may also be used for other purposes discussed herein.
FILED Tuesday, December 15, 2020
APPL NO 17/122392
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/24 (20130101)
A61L 27/3654 (20130101)
A61L 27/3662 (20130101)
A61L 27/3687 (20130101) Original (OR) Class
A61L 2430/06 (20130101)
A61L 2430/40 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187262 Ozdoganlar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Carnegie Mellon University (Pittsburgh, Pennsylvania);  University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) O. Burak Ozdoganlar (Sewickley, Pennsylvania);  Marcel P. Bruchez (Edgewood, Pennsylvania);  Phil G. Campbell (Pittsburgh, Pennsylvania);  Jonathan W. Jarvik (Pittsburgh, Pennsylvania);  Louis Falo (Wexford, Pennsylvania);  Geza Erdos (Wexford, Pennsylvania)
ABSTRACT Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
FILED Wednesday, December 23, 2020
APPL NO 17/132511
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0006 (20130101)
A61K 49/0045 (20130101)
A61K 49/0097 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 37/0015 (20130101) Original (OR) Class
A61M 37/0084 (20130101)
A61M 2037/0061 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2750/14143 (20130101)
C12N 2830/002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187280 Park et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Hongkun Park (Cambridge, Massachusetts);  Donhee Ham (Cambridge, Massachusetts);  Jeffrey T. Abbott (Cambridge, Massachusetts);  Ling Qin (Cambridge, Massachusetts);  Marsela Jorgolli (Cambridge, Massachusetts);  Tianyang Ye (Cambridge, Massachusetts)
ABSTRACT The present invention generally relates to nanowires. In one aspect, the present invention is generally directed to systems and methods of individually addressing nanowires on a surface, e.g., that are substantially upstanding or vertically-oriented with respect to the surface. In some cases, one or more nanowires may be individually addressed using various integrated circuit (“IC”) technologies, such as CMOS. For example, the nanowires may form an array on top of an active CMOs integrated circuit.
FILED Friday, January 08, 2021
APPL NO 17/144387
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/05 (20130101)
A61N 1/06 (20130101)
A61N 1/0531 (20130101) Original (OR) Class
A61N 1/0536 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 23/48 (20130101)
H01L 23/49 (20130101)
H01L 29/0676 (20130101)
H01L 2924/0002 (20130101)
H01L 2924/14 (20130101)
H01L 2924/10253 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187330 Bailey et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Michael R. Bailey (Seattle, Washington);  Adam D. Maxwell (Seattle, Washington);  Akshay Purushottamji Randad (Seattle, Washington);  Mohamed Abdalla Ghanem (Seattle, Washington)
ABSTRACT Apparatus and method for ultrasound beam shaping are disclosed herein. In one embodiment, an ultrasonic therapy system is configured to apply ultrasound to a target in a body. The system includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable lens configured to focus the ultrasound onto a focal area of the target. The target is an object or a portion of the object in the body. The customizable lens is designed and produced based on at least one acquired image of the target.
FILED Wednesday, August 14, 2019
APPL NO 17/268838
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/225 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 7/00 (20130101) Original (OR) Class

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/40 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188763 Chute et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) John P. Chute (Los Angeles, California);  Michael E. Jung (Los Angeles, California);  Emelyne Diers (Dundee, Scotland, United Kingdom);  Hyo Jin Gim (Los Angeles, California);  Martina Roos (Los Angeles, California)
ABSTRACT The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.
FILED Thursday, November 29, 2018
APPL NO 16/767919
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/06 (20180101)

Acyclic or Carbocyclic Compounds
C07C 205/43 (20130101)
C07C 225/20 (20130101) Original (OR) Class
C07C 225/22 (20130101)
C07C 233/15 (20130101)
C07C 233/66 (20130101)
C07C 233/88 (20130101)
C07C 255/58 (20130101)
C07C 311/39 (20130101)

Heterocyclic Compounds
C07D 207/333 (20130101)
C07D 211/58 (20130101)
C07D 213/50 (20130101)
C07D 213/74 (20130101)
C07D 231/12 (20130101)
C07D 231/56 (20130101)
C07D 249/06 (20130101)
C07D 307/52 (20130101)
C07D 317/66 (20130101)
C07D 333/22 (20130101)
C07D 333/36 (20130101)
C07D 401/06 (20130101)

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 7/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188792 RIVKEES
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Scott A. RIVKEES (Gainesville, Florida)
ABSTRACT The invention is directed towards compounds, methods of stimulating myelination, stimulating proliferation of oligodendrocytes (OLs) or stimulating oligodendrocyte precursor cells and methods of treating diseases, disorders or symptoms thereof.
FILED Friday, May 10, 2019
APPL NO 17/054600
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Heterocyclic Compounds
C07D 285/24 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188793 CISAR et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) Lundbeck La Jolla Research Center, Inc. (San Diego, California);  THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
ASSIGNEE(S)
INVENTOR(S) Justin S. CISAR (San Diego, California);  Cheryl A. GRICE (Encinitas, California);  Todd K. JONES (Solana Beach, California);  Micah J. NIPHAKIS (San Diego, California);  Jae Won CHANG (San Diego, California);  Kenneth M. LUM (San Diego, California);  Benjamin F. CRAVATT (San Diego, California)
ABSTRACT This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
FILED Monday, March 08, 2021
APPL NO 17/195351
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/22 (20180101)

Acyclic or Carbocyclic Compounds
C07C 271/10 (20130101)
C07C 271/12 (20130101)

Heterocyclic Compounds
C07D 205/04 (20130101)
C07D 207/09 (20130101)
C07D 207/14 (20130101)
C07D 213/38 (20130101)
C07D 213/40 (20130101)
C07D 213/55 (20130101)
C07D 215/42 (20130101)
C07D 215/46 (20130101)
C07D 231/12 (20130101)
C07D 231/16 (20130101)
C07D 231/56 (20130101)
C07D 241/04 (20130101)
C07D 261/08 (20130101)
C07D 263/32 (20130101)
C07D 271/06 (20130101)
C07D 295/26 (20130101)
C07D 295/205 (20130101) Original (OR) Class
C07D 307/79 (20130101)
C07D 317/46 (20130101)
C07D 317/58 (20130101)
C07D 401/04 (20130101)
C07D 401/10 (20130101)
C07D 403/10 (20130101)
C07D 405/14 (20130101)
C07D 407/06 (20130101)
C07D 413/06 (20130101)
C07D 413/10 (20130101)
C07D 471/04 (20130101)
C07D 471/10 (20130101)
C07D 487/04 (20130101)
C07D 491/107 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188843 Huang et al.
FUNDED BY
Department of Defense (DOD)
Uniformed Services University of the Health Sciences (USU)
Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancment of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S) Wenwei Huang (Rockville, Maryland);  Hao Li (Rockville, Maryland);  Wei Zheng (Potomac, Maryland);  Wei Sun (Germantown, Maryland);  Xiuli Huang (Potomac, Maryland);  Xiao Lu (Rockville, Maryland);  Philip E. Sanderson (Bethesda, Maryland);  Xin Xu (Rockville, Maryland);  Pranav Shah (Gaithersburg, Maryland);  Kim C. Williamson (Bethesda, Maryland);  Zhiji Luo (Rockville, Maryland);  Gregory J. Tawa (Doylestown, Pennsylvania)
ABSTRACT Disclosed are compounds of formula (I) wherein R1, R2, R3, A, and B are as defined herein, and a method of preparing such compounds. Also disclosed are pharmaceutical compositions containing the compound of formula (I) and a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria by killing or arresting the growth of Plasmodium organisms in a mammal, wherein the Plasmodium organisms are in a liver stage, an asexual stage, or gametocytes, comprising administering to an animal an effective amount of a compound of formula (I).
FILED Monday, May 13, 2019
APPL NO 17/054614
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 33/06 (20180101)

Heterocyclic Compounds
C07D 471/04 (20130101) Original (OR) Class
C07D 519/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188851 BURNS et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) VenatoRx Pharmaceuticals, Inc. (Malvern, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Christopher J. BURNS (Malvern, Pennsylvania);  Guo-Hua CHU (Exton, Pennsylvania);  Jodie HAMRICK (New Holland, Pennsylvania);  Steven A. Boyd (Chester Springs, Pennsylvania);  Stephen M. CONDON (Glenmoore, Pennsylvania)
ABSTRACT The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.
FILED Wednesday, May 29, 2019
APPL NO 17/057594
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/407 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Heterocyclic Compounds
C07D 477/20 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188858 Gangjee
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Duquesne University of the Holy Spirit (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Aleem Gangjee (Allison Park, Pennsylvania)
ABSTRACT This invention provides substituted bicyclic pyrimidine compounds of the following formula: or a pharmaceutically acceptable salt thereof, wherein R is NH2. Methods of treating a patient diagnosed with cancer are disclosed comprising administering to the patient a therapeutically effective amount of the substituted bicyclic pyrimidine compounds, or a pharmaceutically acceptable salt thereof.
FILED Tuesday, December 22, 2020
APPL NO 17/130395
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
A61P 35/02 (20180101)

Heterocyclic Compounds
C07D 487/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188880 Ting et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York);  MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Richard Ting (New York, New York);  Omer Aras (New York, New York);  Feifei An (New York, New York);  Nandi Chen (New York, New York)
ABSTRACT A compound according to Formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, wherein X1 and X2 are each independently 18F or 19F; R1 and R2 are each independently alkyl, amine, perfluoroalkyl, alkenyl, alkynyl, aryl, or aralkenyl; and R3 is H, halo, alkyl, alkyl ester, alkenyl, alkynyl, aryl, or aralkenyl; or wherein: R1 and R3 or R2 and R3 join to form a 6-membered cycloalkyl or heterocyclyl; or R1 and R3, R2 and R3, or R1, R2, and R3 join to form a substituted or unsubstituted polycyclic ring, wherein the polycyclic ring comprises fused cycloalkyl, heterocycloalkyl, aryl, or heteroaryl rings.
FILED Thursday, May 23, 2019
APPL NO 17/057284
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)

General Methods of Organic Chemistry; Apparatus Therefor
C07B 2200/05 (20130101)

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 5/025 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188891 BLAGG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) UNIVERSITY OF KANSAS (Lawrence, Kansas)
ASSIGNEE(S)
INVENTOR(S) Brian S.J. BLAGG (Lawrence, Kansas);  Bhaskar Reddy KUSUMA (Lake Ronkonkoma, New York);  Teather SUNDSTROM (Eckelson, North Dakota)
ABSTRACT Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.
FILED Friday, December 04, 2020
APPL NO 17/112060
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 211/17 (20130101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 15/203 (20130101)
C07H 15/207 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188898 Micalizio
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S)
INVENTOR(S) Glenn C. Micalizio (Norwich, Vermont)
ABSTRACT The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma.
FILED Wednesday, March 03, 2021
APPL NO 17/191281
CURRENT CPC
Steroids
C07J 1/0055 (20130101)
C07J 75/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188907 Paskewitz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Susan M. Paskewitz (Madison, Wisconsin);  Mayur K. Kajla (Madison, Wisconsin)
ABSTRACT Insect-repellent compositions containing compounds of Formula I: wherein R is a 5-membered or 6-membered carbon-containing ring, having zero, one, two, or three double bonds, and having zero, one, two, or three heteroatoms, wherein the one, two, or three heteroatoms, if present, are selected from nitrogen, oxygen, and sulfur; “x” is an integer from 0 to 5; and “y” is an integer from 1 to 10.
FILED Thursday, October 10, 2019
APPL NO 16/598489
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 43/64 (20130101)

Peptides
C07K 7/02 (20130101) Original (OR) Class
C07K 7/56 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188909 Teesalu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California)
ASSIGNEE(S) Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California)
INVENTOR(S) Tambet Teesalu (La Jolla, California);  Erkki Ruoslahti (La Jolla, California);  Kazuki Sugahara (La Jolla, California);  Shweta Sharma (La Jolla, California)
ABSTRACT Disclosed are peptides and peptidomimetics that in some embodiments include the amino acid sequence KRGARST or (SEQ ID NO: 1), AKRGARSTA or (SEQ ID NO: 2), or CKRGARSTC (SEQ ID NO: 3). Also disclosed are conjugates and compositions that include the peptides and/or peptidomimetics, methods for directing a moiety to tumor lymphatic vasculature, methods for imaging tumor lymphatic vasculature, methods for reducing or inhibiting tumor metastasis, methods for reducing the number of tumor lymphatic vessels, methods for treating cancer, methods for treating a disease or disorder associated with a gC1q/p32 receptor biological activity, methods for detecting the presence of a gC1q/p32 receptor, methods for detecting interactions between gC1q/p32 receptors and the presently disclosed conjugates and compositions, methods for delivering the presently disclosed conjugates and compositions to gC1q/p32 receptors, methods for assessing gC1q/p32 receptor levels in cells, methods for identifying subjects having diseases associated with gC1q/p32 receptor biological activities, and methods for screening for compounds that interact with gC1q/p32 receptors.
FILED Monday, June 01, 2020
APPL NO 16/889137
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 47/64 (20170801)
A61K 49/1866 (20130101)

Peptides
C07K 7/06 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6872 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188914 Liu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Jun O. Liu (Clarksville, Maryland);  Jingxin Wang (Baltimore, Maryland);  Zufeng Guo (Baltimore, Maryland);  Wei Li (Xiangtan, China PRC);  Shridhar Bhat (Cockeysville, Maryland);  Manisha Das (Centreville, Virginia)
ABSTRACT Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
FILED Thursday, February 25, 2021
APPL NO 17/185658
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/436 (20130101)
A61K 31/4353 (20130101)

Heterocyclic Compounds
C07D 471/04 (20130101)
C07D 498/04 (20130101)
C07D 498/14 (20130101)
C07D 515/04 (20130101)
C07D 515/14 (20130101)

Peptides
C07K 7/645 (20130101) Original (OR) Class
C07K 17/08 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/566 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188917 Chang et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Gwong-Jen J. Chang (Fort Collins, Colorado);  Brent S. Davis (Fort Collins, Colorado)
ABSTRACT Transcriptional units encoding Zika virus (ZIKV) premembrane (prM) and envelope (E) proteins, which upon translation form Zika virus-like particles (VLPs), are described. Use of the transcriptional units and VLPs in three different ZIKV vaccine platforms is described. Immunoassay-based detection methods using ZIKV VLPs are described for the diagnosis of ZIKV infection.
FILED Friday, February 05, 2021
APPL NO 17/168889
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 2039/53 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 14/005 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56983 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188920 LENOUEN et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland);  CODAGENIX, INC. (Farmingdale, New York)
ASSIGNEE(S)
INVENTOR(S) Cyril LENOUEN (Bethesda, Maryland);  Ursula J. BUCHHOLZ (Silver Spring, Maryland);  Peter L. COLLINS (Silver Spring, Maryland);  Steffen MUELLER (Stony Brook, New York)
ABSTRACT Reported herein are presumptively de-attenuating mutations that are useful, either individually or in combinations that may include other known mutations, in producing recombinant strains of human respiratory syncytial virus (RSV) exhibiting attenuation phenotypes. Also described herein is a novel RSV construct, Min_L-NPM2-1(N88K)L, which exhibits an attenuated phenotype, is stable and is as immunogenic as wild type RSV. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Exemplary vaccine candidates are described. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses.
FILED Monday, August 31, 2020
APPL NO 17/008025
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/0043 (20130101)
A61K 39/155 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/20 (20180101)

Peptides
C07K 14/08 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/04 (20130101)
C12N 2760/00021 (20130101)
C12N 2760/00034 (20130101)
C12N 2760/00062 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188921 Kwong et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary,Department of Health and Human Service (Bethesda, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary,Department of Health and Human Service (Bethesda, Maryland)
INVENTOR(S) Peter Kwong (Washington, District of Columbia);  John Mascola (Rockville, Maryland);  Gwo-Yu Chuang (Rockville, Maryland);  Hui Geng (Rockville, Maryland);  Yongping Yang (Potomac, Maryland);  Cheng Cheng (Bethesda, Maryland);  Jeffrey Boyington (Clarksburg, Maryland);  Yen-Ting Lai (Bethesda, Maryland)
ABSTRACT Immunogens comprising a recombinant HIV-1 Env ectodomain trimer stabilized in a prefusion closed conformation and methods of their use and production are disclosed. In several embodiments, the immunogen can be used to elicit an immune response to HIV-1 in a subject.
FILED Tuesday, October 16, 2018
APPL NO 16/756777
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/39 (20130101)
A61K 2039/64 (20130101)

Peptides
C07K 14/162 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188948 Zanini et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Chan Zuckerberg Biohub, Inc. (San Francisco, California);  The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Fabio Zanini (Stanford, California);  Derek Croote (Stanford, California);  Makeda L. Robinson (Stanford, California);  Leslie Goo (San Francisco, California);  Stephen R. Quake (San Francisco, California);  Shirit Einav (Stanford, California);  Krista McCutcheon (San Francisco, California);  Eric Waltari (San Francisco, California)
ABSTRACT Provided are antibodies or antigen binding portions thereof that specifically bind Dengue virus, various compositions of such antibodies or antigen binding portions thereof, and methods of their use. The disclosure provides such antibodies, fragments of such antibodies retaining Dengue virus-binding ability, pharmaceutical compositions including such antibodies or antigen binding fragments thereof, and diagnostic compositions including such antibodies or antigen binding fragments thereof. This disclosure further provides for isolated nucleic acids encoding such antibodies, amino acid sequences of such antibodies, and host cells transformed therewith. Additionally, this disclosure provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the disclosure.
FILED Wednesday, August 07, 2019
APPL NO 17/265704
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/505 (20130101)

Peptides
C07K 16/10 (20130101) Original (OR) Class
C07K 2317/565 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/563 (20130101)
G01N 33/56983 (20130101)
G01N 2333/185 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188952 RICE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Peter A. RICE (Southborough, Massachusetts);  Sunita GULATI (Spencer, Massachusetts);  Sanjay RAM (Worcester, Massachusetts)
ABSTRACT Provided are humanized antibodies that bind to the 2C7 epitope of Neisseria gonorrhoeae. Also provided are compositions and methods for treating Neisseria gonorrhoeae infection in a subject in need thereof.
FILED Friday, November 16, 2018
APPL NO 16/762032
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Peptides
C07K 16/1217 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/732 (20130101)
C07K 2317/734 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188953 Shoemaker
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Trustees of Tufts College (Medford, Massachusetts)
ASSIGNEE(S) Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S) Charles B. Shoemaker (Medford, Massachusetts)
ABSTRACT Provided are multicomponent heteromultimeric binding protein molecules, which comprise heavy-chain-only variable domains (VHH) that specifically bind and neutralize target disease-causing agents, e.g., toxin proteins, such as C. difficile toxin A and/or toxin B, or C. botulinum toxin A and/or toxin B. The multimeric or heteromultimeric VHH-based neutralizing agents are called VNA binding molecules. Also provided are polynucleotides which encode the VNA binding molecules. Compositions, methods and kits comprising such multimeric binding protein molecules and polynucleotides are provided for treating a subject who has been exposed to, or who is at risk of exposure to, such disease-causing agents.
FILED Thursday, September 06, 2018
APPL NO 16/761969
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5123 (20130101)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Peptides
C07K 16/1282 (20130101) Original (OR) Class
C07K 2317/31 (20130101)
C07K 2317/76 (20130101)
C07K 2317/569 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188959 Liu et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Augusta University Research Institute, Inc. (Augusta, Georgia);  Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Kebin Liu (Augusta, Georgia);  John Klement (Augusta, Georgia);  Priscilla S. Redd (Augusta, Georgia)
ABSTRACT Antibodies and antigen binding fragments thereof that immunospecifically bind OPN (OPN) and inhibit OPN activity are provided herein. The disclosed antibodies and antigen binding fragments are useful for modulating signal transduction through OPN proteins. The antibodies and antigen-binding fragments are useful for the treatment or prevention of cancer, osteoporosis, or other immune diseases.
FILED Friday, December 04, 2020
APPL NO 17/112098
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)
A61K 2039/505 (20130101)

Peptides
C07K 16/24 (20130101) Original (OR) Class
C07K 2317/565 (20130101)
C07K 2319/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189012 Mao et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S)
INVENTOR(S) Chuanbin Mao (Norman, Oklahoma);  Lin Wang (Norman, Oklahoma);  Penghe Qiu (Norman, Oklahoma)
ABSTRACT A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide.
FILED Thursday, April 02, 2020
APPL NO 16/838798
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/0011 (20130101)
A61K 39/39 (20130101)
A61K 39/385 (20130101)
A61K 2039/60 (20130101)
A61K 2039/627 (20130101)
A61K 2039/645 (20130101)
A61K 2039/55561 (20130101)

Peptides
C07K 17/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189313 Laurencin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Cato T. Laurencin (Farmington, Connecticut);  Lakshimi S. Nair (Farmington, Connecticut);  Mohammed Barajaa (Farmington, Connecticut)
ABSTRACT System and methods for the culturing of multiple independent cell types under uniform conditions.
FILED Thursday, December 17, 2020
APPL NO 17/124728
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/12 (20130101)
C12M 23/34 (20130101) Original (OR) Class
C12M 37/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189345 KLEMKE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (La Jolla, California)
ASSIGNEE(S)
INVENTOR(S) Richard KLEMKE (La Jolla, California);  Huawei WANG (San Diego, California)
ABSTRACT Provided are cytoplasts (enucleated cells), methods for making cytoplasts, compositions comprising cytoplasts, and methods for using cytoplasts.
FILED Monday, January 11, 2021
APPL NO 17/145848
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 35/28 (20130101)
A61K 38/2066 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0662 (20130101) Original (OR) Class
C12N 15/85 (20130101)
C12N 2501/999 (20130101)
C12N 2510/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189349 Wells et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) Children's Hospital Medical Center (Cincinnati, Ohio)
ASSIGNEE(S)
INVENTOR(S) James M. Wells (Cincinnati, Ohio);  Stephen Trisno (Cincinnati, Ohio)
ABSTRACT The instant disclosure relates to methods for converting mammalian definitive endoderm (DE) cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the disclosure relates to formation of esophageal tissue and/or organoids formed from differentiated definitive endoderm.
FILED Friday, October 05, 2018
APPL NO 16/755193
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0271 (20130101)
A01K 2207/30 (20130101)
A01K 2227/105 (20130101)
A01K 2267/0306 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 35/37 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/04 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0062 (20130101)
C12N 5/0679 (20130101) Original (OR) Class
C12N 2500/38 (20130101)
C12N 2501/11 (20130101)
C12N 2501/41 (20130101)
C12N 2501/119 (20130101)
C12N 2501/155 (20130101)
C12N 2501/415 (20130101)
C12N 2506/02 (20130101)
C12N 2506/45 (20130101)
C12N 2513/00 (20130101)
C12N 2533/54 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5044 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189359 Zhan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)
INVENTOR(S) Chang-Guo Zhan (Lexington, Kentucky);  Fang Zheng (Lexington, Kentucky);  Xiabin Chen (Lexington, Kentucky)
ABSTRACT The presently-disclosed subject matter describes fusion proteins comprising butyrylcholinesterase (BChE) having an improved production yield and biological half-life and nucleotides encoding the same.
FILED Monday, December 21, 2020
APPL NO 17/129736
CURRENT CPC
Peptides
C07K 2319/30 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/18 (20130101) Original (OR) Class

Enzymes
C12Y 301/01008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189361 Chiba-Falek et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Ornit Chiba-Falek (Durham, North Carolina);  Boris Kantor (Durham, North Carolina)
ABSTRACT Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based epigenome modifier compositions for epigenomic modification of a SNCA gene and methods of use thereof.
FILED Tuesday, April 23, 2019
APPL NO 17/050009
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 2319/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101) Original (OR) Class
C12N 9/1007 (20130101)
C12N 15/11 (20130101)
C12N 15/86 (20130101)
C12N 2310/20 (20170501)
C12N 2740/15043 (20130101)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189381 CRAIGHEAD et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S) CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S) Harold G. CRAIGHEAD (Ithaca, New York);  Juraj TOPOLANCIK (San Jose, California);  Harvey TIAN (Fayetteville, Arkansas);  Christopher WALLIN (Ithaca, New York)
ABSTRACT The present invention relates to a microfluidic device for extracting and isolating DNA from cells. The device includes a support having an inlet port for receiving a sample containing a cell, an outlet port for dispensing DNA isolated from the cell, and a microfluidic channel disposed within the support and extending from the inlet port to the outlet port. The microfluidic channel includes a micropillar array, an inflow channel disposed between the inlet port and the micropillar array, and an outflow channel disposed between the micropillar array and the outlet port. The micropillar array includes micropillars spatially configured to entrap, by size exclusion, the cell, to immobilize DNA released from the cell, and to maintain the immobilized DNA in elongated or non-elongated form when hydrodynamic force is applied to the microfluidic channel. Systems and methods of making and using the device are also provided herein.
FILED Saturday, March 06, 2021
APPL NO 17/194253
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502761 (20130101)
B01L 2200/0663 (20130101)
B01L 2400/086 (20130101)
B01L 2400/0415 (20130101)
B01L 2400/0487 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 47/10 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1017 (20130101) Original (OR) Class

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 29/49826 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189388 Church et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) George M. Church (Brookline, Massachusetts);  Luhan Yang (Somerville, Massachusetts);  Margo R. Monroe (Boston, Massachusetts);  Po-Yi Huang (Boston, Massachusetts)
ABSTRACT Methods and compositions of altering a eukaryotic cell are described including providing to the eukaryotic cell a guide DNA sequence complementary to a target nucleic acid sequence, providing to the eukaryotic cell an Ago enzyme or a nuclease null Ago protein that interacts with the guide DNA sequence for DNA-guided gene editing and regulation of the target nucleic acid sequence in a site specific manner.
FILED Tuesday, February 07, 2017
APPL NO 16/076022
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/113 (20130101) Original (OR) Class

Enzymes
C12Y 306/04013 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189399 Hromas et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Robert A. Hromas (Gainesville, Florida);  Elizabeth Williamson (Gainesville, Florida);  Gayathri Srinivasan (Gainesville, Florida)
ABSTRACT The subject invention provides a pharmaceutical composition comprising an inhibitory RNA (iRNA) that mediates sequence-specific degradation of the mRNA encoding Poly (ADP-ribose) polymerase 1 (PARP1) and methods of treating cancers by administering the pharmaceutical composition to a subject in need thereof. In one embodiment, the iRNA is miR-223, particularly, miR-223-3p or a modified miR-223-3p having substitutions and/or deletions in the sequence of miR-223-3p. In another embodiment, the cancer cells comprise one or more mutations in the genes that mediate homologous recombination DNA repair, for example, BRCA1 and/or BRCA2 genes. The cancer can be breast cancer, ovarian cancer, prostate cancer, pancreatic cancer or mesothelioma. Methods of treating cancer, for example, a cancer comprising BRCA1 and/or 2 mutations, using a combination of iRNA and a second cancer therapeutic are also provided.
FILED Friday, April 14, 2017
APPL NO 16/093465
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/127 (20130101)
A61K 31/7068 (20130101)
A61K 47/646 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1137 (20130101) Original (OR) Class
C12N 2310/141 (20130101)
C12N 2310/3513 (20130101)
C12N 2320/31 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189407 WILLIAMS
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Nature Technology Corporation (Lincoln, Nebraska)
ASSIGNEE(S) Nature Technology Corporation (Lincoln, Nebraska)
INVENTOR(S) James A. WILLIAMS (Lincoln, Nebraska)
ABSTRACT A eukaryotic replicative pUC-free minicircle expression vector is provided. The eukaryotic replicative pUC-free minicircle expression vector includes a pUC-free eukaryotic region sequence encoding a transgene of interest and comprising 5′ and 3′ ends and a ii) pUC-free spacer region of less than 500 basepairs in length linking the 5′ and 3′ ends of the eukaryotic region sequences and comprising a bacterial R6K replication origin having at least 95% sequence identity to SEQ ID NO: 11 and SEQ ID NO: 12 and a RNA selectable marker, the RNA selectable marker being an RNA-IN regulating RNA-OUT functional variant having at least 95% sequence identity to SEQ ID NO: 20 or SEQ ID NO: 22.
FILED Thursday, September 24, 2020
APPL NO 17/031791
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/63 (20130101)
C12N 15/64 (20130101)
C12N 15/67 (20130101)
C12N 15/79 (20130101) Original (OR) Class
C12N 15/85 (20130101)
C12N 2800/24 (20130101)
C12N 2820/55 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 19/34 (20130101)
C12P 21/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189425 Munir et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Shirin Munir (Potomac, Maryland);  Linda G. Brock (Wyckoff, New Jersey);  Ursula J. Buchholz (Silver Spring, Maryland);  Peter L. Collins (Silver Spring, Maryland)
ABSTRACT Disclosed are live, chimeric non-human Mononegavirales vectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.
FILED Tuesday, April 23, 2019
APPL NO 17/049916
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/155 (20130101)
A61K 2039/5256 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101) Original (OR) Class
C12N 2760/18534 (20130101)
C12N 2760/18544 (20130101)
C12N 2760/18551 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189428 Lu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S) Yuan Lu (Gainesville, Florida);  Chen Ling (Shanghai, China PRC);  Arun Srivastava (Gainesville, Florida)
ABSTRACT Provided herein are recombinant adeno-associated virus (rAAV) nucleic acid vectors that comprise one or more modifications within at least one inverted terminal repeat (ITR) region. Exemplary modifications include ITR sequences comprising a glucocorticoid responsive element and/or a transcription factor binding site. Also provided are plasmids, libraries, rAAV particles, compositions, kits, and methods related to such vectors.
FILED Wednesday, January 13, 2021
APPL NO 17/148425
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101) Original (OR) Class
C12N 2750/14122 (20130101)
C12N 2750/14143 (20130101)
C12N 2830/002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189431 Putman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Yale University (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Rachael Putman (Belton, Missouri);  Adele S. Ricciardi (New Haven, Connecticut);  Peter M. Glazer (Guilford, Connecticut);  W. Mark Saltzman (New Haven, Connecticut)
ABSTRACT Methods for gene editing of embryos in vitro are provided. The methods typically include contacting an embryo in vitro with an effective amount of non-enzymatic (e.g., non-nuclease) gene editing active agent(s) optionally encapsulated, entrapped, complexed to or dispersed in polymeric particles to induce at least one alteration in the genome of the embryo. The embryo can be a single cell zygote, however, treatment of male and female gametes prior to fertilization, and embryos having 2, 4, 8, or 16 cells, and including not only zygotes, but also morulas and blastocysts are also provided. Typically, the embryo is contacted with the particles on culture days 0-6 during or following in vitro fertilization.
FILED Monday, August 12, 2019
APPL NO 17/267755
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/88 (20130101)
C12N 15/873 (20130101) Original (OR) Class
C12N 15/907 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189445 Smolke et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Science Foundation (NSF)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Christina D. Smolke (Menlo Park, California);  Catherine Thodey (Mountain View, California);  Isis Trenchard (Redwood City, California);  Stephanie Galanie (Palo Alto, California)
ABSTRACT Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention.
FILED Tuesday, October 13, 2020
APPL NO 17/069066
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0073 (20130101)
C12N 9/1007 (20130101)
C12N 15/52 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 17/18 (20130101)
C12P 17/182 (20130101) Original (OR) Class

Enzymes
C12Y 121/03003 (20130101)
C12Y 201/0114 (20130101)
C12Y 201/01116 (20130101)
C12Y 201/01128 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189463 Seelig et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Georg Seelig (Seattle, Washington);  Richard Muscat (Seattle, Washington);  Alexander B. Rosenberg (Seattle, Washington)
ABSTRACT Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
FILED Thursday, February 25, 2021
APPL NO 17/249257
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101) Original (OR) Class
C12Q 1/6855 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189466 Shepard et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) BioSpyder Technologies, Inc. (Carlsbad, California)
ASSIGNEE(S)
INVENTOR(S) Peter J. Shepard (Carlsbad, California);  Joanne M. Yeakley (Encinitas, California);  Bruce Seligmann (Tucson, California)
ABSTRACT Methods for designing oligonucleotide probes for detecting and profiling expression products at transcriptome scale.
FILED Monday, March 01, 2021
APPL NO 17/188319
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6813 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189480 Gundlach et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) University of Washington (Seattle, Washington);  The UAB Research Foundation (Birmingham, Alabama)
ASSIGNEE(S) University of Washington (Seattle, Washington);  The UAB Research Foundation (Birmingham, Alabama)
INVENTOR(S) Jens H. Gundlach (Seattle, Washington);  Michael Niederweis (Homewood, Alabama);  Thomas Z. Butler (Seattle, Washington);  Mikhail Pavlenok (Birmingham, Alabama);  Mark A. Troll (Seattle, Washington);  Suja Sukumaran (Dublin, California)
ABSTRACT Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
FILED Monday, December 14, 2020
APPL NO 17/121621
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/00 (20130101)
A61K 39/04 (20130101)

Peptides
C07K 14/35 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 13/00 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/44704 (20130101)
G01N 27/44791 (20130101)
G01N 33/6872 (20130101)
G01N 33/48721 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189482 Akeson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Mark A. Akeson (Santa Cruz, California);  David W. Deamer (Santa Cruz, California);  William B. Dunbar (Santa Cruz, California);  Roger Jinteh Arrigo Chen (Saratoga, California);  Noah A. Wilson (Felton, California)
ABSTRACT Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
FILED Friday, November 13, 2020
APPL NO 17/098101
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/54 (20130101)
C12Q 1/6869 (20130101)
C12Q 1/6874 (20130101) Original (OR) Class

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 3/29 (20210101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/3278 (20130101)
G01N 27/4166 (20130101)
G01N 33/48721 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189485 Cheng et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Jackson Laboratory (Bar Harbor, Maine)
ASSIGNEE(S) The Jackson Laboratory (Bar Harbor, Maine)
INVENTOR(S) Albert Cheng (Bar Harbor, Maine);  Aziz Taghbalout (Bristol, Connecticut);  Nathaniel Lee Jillette (Bar Harbor, Maine)
ABSTRACT The present disclosure, in some embodiments, provides sequence detection systems (sequence detectors) for the detection of specific nucleotides sequences present in the genome of live cells (e.g., single live cells) to achieve, for example, in vivo and in situ imaging, cell selection, and/or cell ablation.
FILED Tuesday, November 06, 2018
APPL NO 16/761298
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101)
C12Q 1/6876 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189499 DENG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Metabolomic Technologies Inc. (Edmonton, Canada)
ASSIGNEE(S) Metabolomic Technologies Inc. (Edmonton, Canada)
INVENTOR(S) Lu DENG (Edmonton, Canada);  David CHANG (Edmonton, Canada)
ABSTRACT The invention relates to methods and compositions for detecting colorectal cancer and colorectal polyps by measurement of metabolites in bodily fluids such as urine, including diacetylspermine and kynurenine.
FILED Monday, December 23, 2019
APPL NO 16/725914
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/106 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 2800/50 (20130101)
G01N 2800/52 (20130101)
G01N 2800/7028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189502 Feinberg
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Human Genome Research Institute (NHGRI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S) The Johns Hopkins University (, None)
INVENTOR(S) Andrew P. Feinberg (Lutherville, Maryland)
ABSTRACT Provided herein are tissue-specific differential methylated regions (T-DMRs) and cancer-related differential methylated regions (C-DMRs) and methods of use thereof. In one embodiment of the invention, there are provided methods of detecting a cell proliferative disorder by detecting altered methylation in one or more DMRs identified herein. In another embodiment of the invention, there are provided methods of determining clinical outcome by detecting altered methylation in one or more DMRs identified herein.
FILED Thursday, February 18, 2021
APPL NO 17/179311
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/154 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 436/143333 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189503 VASAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S) MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
INVENTOR(S) Neil VASAN (New York, New York);  Jose BASELGA (New York, New York);  Maurizio SCALTRITI (Long Island City, New York)
ABSTRACT The present disclosure relates to methods for determining the responsiveness of a cancer to a PI3K inhibitor and kits relating thereof. The present disclosure also relates to methods for treating a subject having a cancer, where the cancer has been determined to be responsive to a PI3K inhibitor. In particular, the present disclosure provides combinations of two or more PI3KCA mutations as biomarkers for determining the responsiveness of a cancer cell to a PI3K inhibitor.
FILED Tuesday, February 23, 2021
APPL NO 17/182700
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/106 (20130101)
C12Q 2600/156 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190646 Volckens et al.
FUNDED BY
Department of Health and Human Services (HHS)
Centers for Disease Control and Prevention (CDC)
National Institute for Occupational Safety and Health (NIOSH)
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S) Colorado State University Research Foundation (Fort Collins, Colorado);  Access Sensor Technologies LLC (For Colling, Colorado)
ASSIGNEE(S)
INVENTOR(S) John Volckens (Fort Collins, Colorado);  Daniel D. Miller-Lionberg (Denver, Colorado);  Josephine Hofstetter (Commerce City, Colorado);  Casey William Quinn (Olympia, Washington);  Carter Ellison (Fort Collins, Colorado);  David Leith (Chapel Hill, North Carolina)
ABSTRACT A portable sampling device includes a sampling housing at least partially enclosing an inner chamber; at least one pumping element disposed within the inner chamber and configured to facilitate airflow through the device; and at least one gas sensor disposed within the inner chamber and configured to detect and/or characterize one or more gases in the airflow.
FILED Thursday, May 23, 2019
APPL NO 17/057256
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/24 (20130101)
G01N 1/2205 (20130101)
G01N 1/2214 (20130101)
G01N 1/2273 (20130101) Original (OR) Class
G01N 2001/2276 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190760 Adusumilli
FUNDED BY
Department of Defense (DOD)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S) MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
INVENTOR(S) Prasad S. Adusumilli (New York, New York)
ABSTRACT The present disclosure relates to methods, kits and systems for assessing cytotoxicity of immunoresponsive cells using a pleural effusion. The present disclosure also relates to methods, kits and systems for assessing effect of an immunotherapeutic agent on cytotoxicity of immunoresponsive cells using a pleural effusion.
FILED Friday, March 05, 2021
APPL NO 17/193367
CURRENT CPC
Peptides
C07K 14/7051 (20130101)
C07K 14/70521 (20130101)
C07K 16/30 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/505 (20130101) Original (OR) Class
G01N 2800/7004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190763 Liu
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Misum Biotechnology, LLC (Millburn, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Dongfang Liu (Bellaire, Texas)
ABSTRACT Embodiments of the disclosure concern methods of determining the effectiveness of immune cells, such as T cells, with particular chimeric antigen receptors. In specific embodiments, a synapse between the CAR and the tumor antigen is measured for structure, signaling, and functionality by imaging. As such, the quality of the synapse is determined and positively correlates with effectiveness of the particular CAR immune cells.
FILED Monday, June 08, 2020
APPL NO 16/895707
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)
A61K 39/0011 (20130101)
A61K 2039/5156 (20130101)
A61K 2039/5158 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/30 (20130101)
C07K 16/2803 (20130101)
C07K 16/2818 (20130101)
C07K 16/2878 (20130101)
C07K 17/02 (20130101)
C07K 19/00 (20130101)
C07K 2317/622 (20130101)
C07K 2319/03 (20130101)
C07K 2319/33 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/502 (20130101)
G01N 33/505 (20130101)
G01N 33/544 (20130101)
G01N 33/5032 (20130101) Original (OR) Class
G01N 2333/9645 (20130101)
G01N 2500/00 (20130101)
G01N 2500/04 (20130101)
G01N 2500/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190769 Eng et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Charis Eng (Cleveland, Ohio);  Dennis Lal (Cleveland, Ohio)
ABSTRACT A method of providing a diagnosis for a subject having Cowden-like syndrome or PTEN germline mutations is described. The method includes the steps of: (a) obtaining a biological sample from a subject; (b) conducting a germline PTEN mutation and deletion analysis of genomic DNA from the biological sample; (c) determining the level of copy number variation in the genomic DNA; (d) comparing the level of copy number variation in the genomic DNA to a control value for copy number variation; and (e) diagnosing the subject as having an increased risk of developing a neurodevelopmental disorder if the copy number variation level is higher than the control value.
FILED Monday, December 21, 2020
APPL NO 17/128446
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5308 (20130101) Original (OR) Class
G01N 2496/00 (20130101)
G01N 2800/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190889 YAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Xinqiang YAN (Nashville, Tennessee);  John C. GORE (Nashville, Tennessee);  William A. GRISSOM (Nashville, Tennessee)
ABSTRACT A self-decoupled RF coil and method for adjusting the same is disclosed. The RF coil is an array of elements including at least one loop. Electromagnetic coupling between elements in the array causes an induced current in the at least one loop. The induced current has two modes. A reactance inserted in the at least one loop balances the two modes. The balanced current modes cancel. This cancelation results in self-decoupling of at the least one loop from the other elements in the RF coil array.
FILED Wednesday, March 21, 2018
APPL NO 16/495135
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/365 (20130101) Original (OR) Class
G01R 33/3415 (20130101)
G01R 33/3635 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190892 Yap et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Mental Health (NIMH)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Pew-Thian Yap (Chapel Hill, North Carolina);  Siyuan Liu (Chapel Hill, North Carolina)
ABSTRACT A method for performing retrospective magnetic resonance imaging (MRI) artifact correction includes receiving, as input, an MRI image having at least one artifact; using a trained adversarial network for performing retrospective artifact correction on the MRI image, wherein the trained adversarial network is trained using unpaired artifact-free MRI images and artifact-containing MRI images; and outputting, by the trained adversarial network, a derivative MRI image related to the input, wherein the at least one artifact is corrected in the derivative MRI image.
FILED Friday, December 18, 2020
APPL NO 17/127366
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/055 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/56509 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192727 Ward et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Kevin Ward (Glen Allen., Virginia);  Daniel Francis Taylor (Belleville, Michigan);  Michael W. Sjoding (Ann Arbor, Michigan);  Christopher Elliot Gillies (Ann Arbor, Michigan)
ABSTRACT A computer-implemented method includes preprocessing a variable dimension medical image, identifying one or more areas of interest in the medical image; and analyzing the one or more areas of interest using a deep learning model. A computing system includes one or more processors; and one or more memories storing instructions that, when executed by the one or more processors, cause the computing system to preprocess a variable dimension medical image, identify one or more areas of interest in the medical image; and analyze the one or more areas of interest using a deep learning model. A non-transitory computer readable medium contains program instructions that when executed, cause a computer to preprocess a variable dimension medical image, identify one or more areas of interest in the medical image, and analyze the one or more areas of interest using a deep learning model.
FILED Wednesday, October 28, 2020
APPL NO 17/082145
CURRENT CPC
Electric Digital Data Processing
G06F 17/18 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101) Original (OR) Class
G06T 11/20 (20130101)
G06T 2207/10116 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30061 (20130101)
G06T 2210/12 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/60 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193173 Berisha et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Visar Berisha (Tempe, Arizona);  Ming Tu (Tempe, Arizona);  Alan Wisler (Plano, Texas);  Julie Liss (Scottsdale, Arizona)
ABSTRACT Systems and methods use patient speech samples as inputs, use subjective multi-point ratings by speech-language pathologists of multiple perceptual dimensions of patient speech samples as further inputs, and extract laboratory-implemented features from the patient speech samples. A predictive software model learns the relationship between speech acoustics and the subjective ratings of such speech obtained from speech-language pathologists, and is configured to apply this information to evaluate new speech samples. Outputs may include objective evaluation of the plurality of perceptual dimensions for new speech samples and/or evaluation of disease onset, disease progression, or disease treatment efficacy for a condition involving dysarthria as a symptom, utilizing the new speech samples.
FILED Monday, August 31, 2020
APPL NO 17/008552
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/4803 (20130101)

Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding
G10L 25/51 (20130101)
G10L 25/66 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193267 Cahan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Patrick Cahan (Baltimore, Maryland);  Da Peng (Baltimore, Maryland);  Rachel Gleyzer (Baltimore, Maryland)
ABSTRACT Provided herein are methods of generating training classifiers and/or evaluating cancer models. Related systems and computer program products are also provided.
FILED Wednesday, December 16, 2020
APPL NO 17/123591
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 5/20 (20190201)
G16B 40/00 (20190201) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193297 Buckland et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) Translational Imaging Innovations, Inc. (Hickory, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Eric L. Buckland (Hickory, New York);  Joseph Carroll (New Berlin, Wisconsin);  Robert C. Williams (Durham, North Carolina);  Andrew J. Witchger, JR. (Durham, North Carolina)
ABSTRACT Integrated systems for collecting, storing, and distribution of images acquired of subjects in a research or clinical environment are provided. The system includes an image and data repository including a plurality of images originating from one or more image-generating devices, data associated with the images, and data associated with imaged subjects; and a workflow management module in direct communication with the image and data repository and with the one or more image-generating devices and/or storage devices that store the images of the imaged subjects, the workflow management module being configured to transport the images directly from the one or more image-generating devices and/or storage devices to the image and data repository and to manage the collation and distribution of images, data associated with the raw images and the data associated with the imaged subjects in the image and data repository. The workflow management module includes a data integration module, a data management module, a pre-processing engine and a data utilization module.
FILED Friday, April 03, 2020
APPL NO 16/839475
CURRENT CPC
Electric Digital Data Processing
G06F 9/542 (20130101)
G06F 11/3476 (20130101)
G06F 21/6218 (20130101)
G06F 2221/2141 (20130101)

Image Data Processing or Generation, in General
G06T 7/20 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 30/20 (20180101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194565 Paramesh et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Jeyanandh Paramesh (Pittsburgh, Pennsylvania);  Susnata Mondal (Pittsburgh, Pennsylvania);  L. Richard Carley (Pittsburgh, Pennsylvania)
ABSTRACT Disclosed herein is an innovative multi-layer hybrid/digital MIMO architecture that comprises single-stream or fully-connected (FC) multi-stream beamforming tiles (with RF complex-weights) in the first layer, followed by a fully connected (analog/digital) baseband layer. This architecture overcomes the complexity versus spectral-efficiency tradeoffs of existing hybrid MIMO architectures and enables MIMO stream/user scalability, superior energy-efficiency, and spatial-processing flexibility.
FILED Monday, February 01, 2021
APPL NO 17/164079
CURRENT CPC
Transmission
H04B 1/16 (20130101)
H04B 1/0028 (20130101)
H04B 1/0078 (20130101)
H04B 7/088 (20130101) Original (OR) Class
H04B 7/0413 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20210186326 Sherwood et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Mark B. Sherwood (Gainesville, Florida);  Peng Jiang (Gainesville, Florida);  Aaron David Webel (Columbia, Missouri)
ABSTRACT Described herein are eye implants that can include a pressure-responsive material that can be capable of changing color in response to pressure exerted on it. Also described here are methods of implanting and using the eye implants described herein to monitor intraocular pressure in a subject. The pressure-responsive material can be used to diagnose and monitor human or animal subjects.
FILED Thursday, June 20, 2019
APPL NO 17/051051
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 3/16 (20130101) Original (OR) Class
A61B 5/0075 (20130101)
A61B 5/686 (20130101)

Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/16 (20130101)
A61F 9/00781 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 25/0045 (20130101)
A61M 2205/584 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186963 Wipf et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S) Peter Wipf (Pittsburgh, Pennsylvania);  James K. Johnson (Silver Spring, Maryland);  Erin M. Skoda (Silver Spring, Maryland);  Joel B. Nelson (Pittsburgh, Pennsylvania);  Zhou Wang (Pittsburgh, Pennsylvania);  Serene Tai (Pittsburgh, Pennsylvania);  Keita Takubo (Pittsburgh, Pennsylvania);  John Milligan (Philadelphia, Pennsylvania)
ABSTRACT A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I:
R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(═O), S(═O)(═O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is —C(═O)—, —S(═O)(═O)—, or —N(H)C(═O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.
FILED Wednesday, November 04, 2020
APPL NO 17/089519
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0053 (20130101)
A61K 31/47 (20130101)
A61K 31/122 (20130101)
A61K 31/167 (20130101)
A61K 31/401 (20130101)
A61K 31/407 (20130101)
A61K 31/497 (20130101)
A61K 31/504 (20130101) Original (OR) Class
A61K 31/4166 (20130101)
A61K 31/4439 (20130101)
A61K 31/4985 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187028 COOPER et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Laurence J.N. COOPER (Houston, Texas);  Drew C. DENIGER (Germantown, Maryland)
ABSTRACT Provided herein is a method of expanding clinically-relevant quantities of polyclonal γδ T cells that have anti-tumor, anti-viral, and anti-bacterial reactivity. Polyclonal γδ T cells can target a variety of tumors, including solid tumors as well as other conditions, such as viral and bacterial infections.
FILED Friday, December 18, 2020
APPL NO 17/127627
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class
A61K 39/0011 (20130101)
A61K 2039/572 (20130101)
A61K 2039/5158 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
C12N 5/0638 (20130101)
C12N 2501/515 (20130101)
C12N 2501/2302 (20130101)
C12N 2501/2321 (20130101)
C12N 2502/11 (20130101)
C12N 2502/99 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187447 Kolel-Veetil et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Manoj K. Kolel-Veetil (Alexandria, Virginia);  Paul E. Sheehan (Springfield, Virginia)
ABSTRACT An article having a nanoporous membrane and a nanoporous graphene sheet layered on the nanoporous membrane. A method of: depositing a layer of a diblock copolymer onto a graphene sheet, and etching a minor phase of the diblock copolymer and a portion of the graphene in contact with the minor phase to form a nanoporous article having a nanoporous graphene sheet and a nanoporous layer of a polymer. A method of: depositing a hexaiodo-substituted macrocycle onto a substrate having a Ag(111) surface; coupling the macrocycle to form a nanoporous graphene sheet; layering the graphene sheet and substrate onto a nanoporous membrane with the graphene sheet in contact with the nanoporous membrane; and etching away the substrate.
FILED Thursday, March 04, 2021
APPL NO 17/192380
CURRENT CPC
Separation
B01D 53/228 (20130101)
B01D 69/148 (20130101)
B01D 71/021 (20130101)
B01D 71/44 (20130101) Original (OR) Class
B01D 2053/221 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/442 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187474 SHAIKH et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) XPLOSAFE, LLC (Stillwater, Oklahoma)
ASSIGNEE(S) XPLOSAFE, LLC (Stillwater, Oklahoma)
INVENTOR(S) Shoaib F. SHAIKH (Stillwater, Oklahoma);  Allen W. APBLETT (Stillwater, Oklahoma);  Nicholas F. MATERER (Stillwater, Oklahoma);  Evgueni KADOSSOV (Stillwater, Oklahoma)
ABSTRACT The present invention provides an improved sorbent and corresponding device(s) and uses thereof for the capture and stabilization of volatile organic compounds (VOC) or semi-volatile organic compounds (SVOC) from a gaseous atmosphere. The sorbent is capable of rapid and high uptake of one or more compounds and provides quantitative release (recovery) of the compound(s) when exposed to elevated temperature and/or organic solvent. Uses of particular improved grades of mesoporous silica are disclosed.
FILED Wednesday, December 09, 2020
APPL NO 17/116492
CURRENT CPC
Separation
B01D 53/02 (20130101)
B01D 2253/106 (20130101)
B01D 2257/708 (20130101)
B01D 2259/4583 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/103 (20130101) Original (OR) Class
B01J 20/3204 (20130101)
B01J 20/3219 (20130101)
B01J 20/3246 (20130101)
B01J 20/3293 (20130101)
B01J 20/28021 (20130101)
B01J 20/28064 (20130101)
B01J 20/28073 (20130101)
B01J 20/28076 (20130101)
B01J 20/28083 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 33/18 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/82 (20130101)
C01P 2004/04 (20130101)
C01P 2004/13 (20130101)
C01P 2006/12 (20130101)
C01P 2006/14 (20130101)
C01P 2006/16 (20130101)

Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives
C06B 21/0091 (20130101)
C06B 23/00 (20130101)
C06B 45/00 (20130101)

Blasting
F42D 5/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188076 Morrow et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Oshkosh Defense, LLC (Oshkosh, Wisconsin)
ASSIGNEE(S) Oshkosh Defense, LLC (Oshkosh, Wisconsin)
INVENTOR(S) Jon Morrow (Neenah, Wisconsin);  Dave Steinberger (Oshkosh, Wisconsin);  Eric Braun (Oshkosh, Wisconsin);  Andrew Kotloski (Oshkosh, Wisconsin);  Nader Nasr (Neenah, Wisconsin)
ABSTRACT A drive train includes a first gear set including a sun gear, a ring gear and planetary gears coupling the sun gear to the ring gear, a second gear set including a sun gear, a ring gear and planetary gears coupling the sun gear to the ring gear, a first motor/generator coupled to the first gear set, a second motor/generator coupled to the second gear set, and at least one of (a) a first clutch that selectively engages the second motor/generator with the first gear set and (b) a second clutch that selectively engages the ring gear of the second gear set with the planetary gear carrier of at least one of the first gear set and the second gear set. The planetary gears of both sets are rotatably supported by respective planetary gear carriers.
FILED Monday, November 23, 2020
APPL NO 17/101837
CURRENT CPC
Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles
B60K 6/52 (20130101) Original (OR) Class
B60K 6/365 (20130101)
B60K 6/445 (20130101)
B60K 6/543 (20130101)

Gearing
F16H 3/728 (20130101)
F16H 37/065 (20130101)
F16H 2037/0866 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188420 Louie
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) Jennifer Lai-Jhing Louie (Fredericksburg, Virginia)
ASSIGNEE(S) United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Jennifer Lai-Jhing Louie (Fredericksburg, Virginia)
ABSTRACT A modular quadcopter is provided for vertical flight. The quadcopter includes a housing, a quadrilateral set of extensions, and a quadrilateral set of arms. The housing contains flight control and sensor equipment, and has a relative vertical orientation. The housing is configurable for either stowage or deployment. The extensions are disposed on each corner of the housing. Each extension has a hinge that pitches outward and upward. Each arm is disposed on the hinge and contains an electric motor and a speed controller. The configurable below the housing for the stowage and extends radially from respective the extension in relation to the orientation for the deployment.
FILED Monday, December 23, 2019
APPL NO 16/724478
CURRENT CPC
Aeroplanes; Helicopters
B64C 1/30 (20130101) Original (OR) Class
B64C 39/024 (20130101)
B64C 2201/108 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188716 Laskoski et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Matthew Laskoski (Springfield, Virginia);  Boris Dyatkin (Washington, District of Columbia);  Teddy M. Keller (Fairfax Station, Virginia)
ABSTRACT Disclosed is a composition having nanoparticles or particles of a refractory metal, a refractory metal hydride, a refractory metal carbide, a refractory metal nitride, or a refractory metal boride, an organic compound consisting of carbon and hydrogen, and a nitrogenous compound consisting of carbon, nitrogen, and hydrogen. The composition, optionally containing the nitrogenous compound, is milled, cured to form a thermoset, compacted into a geometric shape, and heated in a nitrogen atmosphere at a temperature that forms a nanoparticle composition comprising nanoparticles of metal nitride and optionally metal carbide. The nanoparticles have a uniform distribution of the nitride or carbide.
FILED Wednesday, March 03, 2021
APPL NO 17/190977
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 21/0617 (20130101)
C01B 21/0641 (20130101)
C01B 21/0682 (20130101)
C01B 21/0761 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/72 (20130101)

Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 35/64 (20130101) Original (OR) Class
C04B 35/76 (20130101)
C04B 35/83 (20130101)
C04B 35/524 (20130101)
C04B 35/583 (20130101)
C04B 35/584 (20130101)
C04B 35/591 (20130101)
C04B 35/6261 (20130101)
C04B 35/6264 (20130101)
C04B 35/58007 (20130101)
C04B 35/58014 (20130101)
C04B 35/58028 (20130101)
C04B 35/58035 (20130101)
C04B 2235/46 (20130101)
C04B 2235/48 (20130101)
C04B 2235/77 (20130101)
C04B 2235/80 (20130101)
C04B 2235/95 (20130101)
C04B 2235/386 (20130101)
C04B 2235/404 (20130101)
C04B 2235/421 (20130101)
C04B 2235/428 (20130101)
C04B 2235/604 (20130101)
C04B 2235/656 (20130101)
C04B 2235/658 (20130101)
C04B 2235/761 (20130101)
C04B 2235/3817 (20130101)
C04B 2235/3856 (20130101)
C04B 2235/3873 (20130101)
C04B 2235/3886 (20130101)
C04B 2235/5248 (20130101)
C04B 2235/5454 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188843 Huang et al.
FUNDED BY
Department of Defense (DOD)
Uniformed Services University of the Health Sciences (USU)
Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancment of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S) Wenwei Huang (Rockville, Maryland);  Hao Li (Rockville, Maryland);  Wei Zheng (Potomac, Maryland);  Wei Sun (Germantown, Maryland);  Xiuli Huang (Potomac, Maryland);  Xiao Lu (Rockville, Maryland);  Philip E. Sanderson (Bethesda, Maryland);  Xin Xu (Rockville, Maryland);  Pranav Shah (Gaithersburg, Maryland);  Kim C. Williamson (Bethesda, Maryland);  Zhiji Luo (Rockville, Maryland);  Gregory J. Tawa (Doylestown, Pennsylvania)
ABSTRACT Disclosed are compounds of formula (I) wherein R1, R2, R3, A, and B are as defined herein, and a method of preparing such compounds. Also disclosed are pharmaceutical compositions containing the compound of formula (I) and a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria by killing or arresting the growth of Plasmodium organisms in a mammal, wherein the Plasmodium organisms are in a liver stage, an asexual stage, or gametocytes, comprising administering to an animal an effective amount of a compound of formula (I).
FILED Monday, May 13, 2019
APPL NO 17/054614
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 33/06 (20180101)

Heterocyclic Compounds
C07D 471/04 (20130101) Original (OR) Class
C07D 519/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188901 Thomas, III et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Space and Naval Warfare Systems (SPAWAR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Dale Arlington Thomas, III (Hampden, Maine);  Alexander James Mijalis (Shreveport, Louisiana);  Bradley L. Pentelute (Cambridge, Massachusetts);  Mark David Simon (Boston, Massachusetts);  Andrea Adamo (Cambridge, Massachusetts);  Patrick Louis Heider (Midland, Michigan);  Klavs F. Jensen (Lexington, Massachusetts)
ABSTRACT Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.
FILED Friday, October 30, 2020
APPL NO 17/086196
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/24 (20130101)
B01J 2219/24 (20130101)

Peptides
C07K 1/045 (20130101)
C07K 1/084 (20130101) Original (OR) Class
C07K 7/06 (20130101)
C07K 14/47 (20130101)
C07K 14/60 (20130101)
C07K 14/61 (20130101)
C07K 14/62 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188950 Chan et al.
FUNDED BY
Department of Defense (DOD)
Uniformed Services University of the Health Sciences (USU)
Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
APPLICANT(S) The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S) The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S) Yee-Peng Chan (Bethesda, Maryland);  Christopher C. Broder (Silver Spring, Maryland)
ABSTRACT The present invention relates to antibodies or antibody fragments that bind, neutralize, and/or inhibit Hendra or Nipah virus. The invention provides antibodies or antibody fragments that selectively bind to the F glycoprotein of Hendra or Nipah virus, and pharmaceutical compositions including such antibodies and/or fragments. The invention further provides polynucleotides encoding the antibodies and fragments of the invention and host cells transformed therewith. Additionally, the invention discloses prophylactic, therapeutic, and diagnostic methods employing the antibodies, fragments, polynucleotides, and/or compositions of the invention.
FILED Monday, August 10, 2020
APPL NO 16/988835
CURRENT CPC
Peptides
C07K 16/1027 (20130101) Original (OR) Class
C07K 2317/21 (20130101)
C07K 2317/24 (20130101)
C07K 2317/34 (20130101)
C07K 2317/51 (20130101)
C07K 2317/55 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)
C07K 2317/565 (20130101)
C07K 2317/569 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188953 Shoemaker
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Trustees of Tufts College (Medford, Massachusetts)
ASSIGNEE(S) Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S) Charles B. Shoemaker (Medford, Massachusetts)
ABSTRACT Provided are multicomponent heteromultimeric binding protein molecules, which comprise heavy-chain-only variable domains (VHH) that specifically bind and neutralize target disease-causing agents, e.g., toxin proteins, such as C. difficile toxin A and/or toxin B, or C. botulinum toxin A and/or toxin B. The multimeric or heteromultimeric VHH-based neutralizing agents are called VNA binding molecules. Also provided are polynucleotides which encode the VNA binding molecules. Compositions, methods and kits comprising such multimeric binding protein molecules and polynucleotides are provided for treating a subject who has been exposed to, or who is at risk of exposure to, such disease-causing agents.
FILED Thursday, September 06, 2018
APPL NO 16/761969
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5123 (20130101)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Peptides
C07K 16/1282 (20130101) Original (OR) Class
C07K 2317/31 (20130101)
C07K 2317/76 (20130101)
C07K 2317/569 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189322 RAO et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
APPLICANT(S) UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (BALTIMORE, Maryland)
ASSIGNEE(S)
INVENTOR(S) GOVIND RAO (ELLICOTT CITY, Maryland);  YORDAN KOSTOV (COLUMBIA, Maryland);  BENJAMIN PUNSHON-SMITH (GWYNN OAK, Maryland);  RAJANI ADIGA (LAUREL, Maryland)
ABSTRACT The present invention relates to cell free protein manufacturing, and more particularly, for integrating machine learning into a portable cell-free bioprocessing system for producing proteins with increased and consistent purity, potency and quality wherein such proteins are prepared on-demand and for point-of-care delivery.
FILED Wednesday, May 15, 2019
APPL NO 17/055149
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/54 (20130101)
C12M 41/48 (20130101) Original (OR) Class
C12M 47/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189379 ISMAGILOV et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Defense Threat Reduction Agency (DTRA)
APPLICANT(S) CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Rustem F. ISMAGILOV (Altadena, California);  Erik JUE (Pasadena, California);  Daan WITTERS (San Diego, California)
ABSTRACT Methods and systems and related compositions for separating through a solid matrix a mixture comprising a nucleic acid in a concentration of 1 μM or less, together with a target compound having a water solubility equal to or greater than 0.001 g per 100 mL, which can be used for managing fluid flow, biochemical reactions and purification of the nucleic acid or other target analytes. The method comprises contacting the solid matrix with a target compound removing agent having a water solubility equal to or less than 0.05 g per 100 mL at 25° C. at 1 atm pressure with water having a solubility in the removing agent of less than 10 g per 100 mL at 25° C. at 1 atm pressure, the contacting performed to remove the target compound from the solid matrix.
FILED Tuesday, December 22, 2020
APPL NO 17/131449
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1006 (20130101) Original (OR) Class
C12N 15/1013 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189580 Matzdorf et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) Craig Matzdorf (Hollywood, Maryland);  Alan Grieve (Springfield, Virginia);  Alexander Westbrook (Lexington Park, Maryland);  Jeremy Mattison (California, Maryland)
ASSIGNEE(S) United States of America as represented by the Secretary of the Navy (Patuxent River, Maryland)
INVENTOR(S) Craig Matzdorf (Hollywood, Maryland);  Alan Grieve (Springfield, Virginia);  Alexander Westbrook (Lexington Park, Maryland);  Jeremy Mattison (California, Maryland)
ABSTRACT This invention is directed to a process of coating metal in a trivalent chromium conversion-electrolyte coating wherein the metal anode or cathode is subjected to a current density ranging up to about 3.0 amperes per square foot for a period ranging up to 60 minutes.
FILED Thursday, December 19, 2019
APPL NO 16/720483
CURRENT CPC
Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor
C25D 3/06 (20130101) Original (OR) Class
C25D 7/0642 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189605 Wetzel et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Laboratory (ARL)
APPLICANT(S) U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland)
ASSIGNEE(S)
INVENTOR(S) Eric D. Wetzel (Baltimore, Maryland);  Larry R. Holmes, JR. (Peach Bottom, Pennsylvania);  Ricardo X. Rodriguez (Pembroke Pines, Florida);  Patrick M. Toal, JR. (Pearl River, New York)
ABSTRACT A thermoplastic filament comprising multiple polymers of differing flow temperatures in a geometric arrangement and an interior channel containing a structural or functional thread therein is described. A method for producing such a filament is also described. Because of the difference in flow temperatures, there exists a temperature range at which one polymer is mechanically stable while the other is flowable. This property is extremely useful for creating thermoplastic monofilament feedstock for three-dimensionally printed parts, wherein the mechanically stable polymer enables geometric stability while the flowable polymer can fill gaps and provide strong bonding and homogenization between deposited material lines and layers. These multimaterial filaments can be produced via thermal drawing from a thermoplastic preform, which itself can be three-dimensionally printed. Furthermore, the preform can be printed with precisely controlled and complex geometries, enabling the creation of a filament or fiber with an interior thread contained within the outer, printed filament or fiber. This thread adds structural reinforcement or functional properties, such as electrical conductivity or optical waveguiding, to the filament.
FILED Tuesday, February 23, 2021
APPL NO 17/182678
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 35/02 (20130101)
B29C 55/00 (20130101)
B29C 64/106 (20170801)
B29C 64/118 (20170801)
B29C 65/565 (20130101)
B29C 66/53 (20130101)
B29C 66/61 (20130101)
B29C 66/5241 (20130101)

Producing Particular Articles From Plastics or From Substances in a Plastic State
B29D 11/00663 (20130101)
B29D 11/00701 (20130101)
B29D 11/00721 (20130101)

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2069/00 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 70/00 (20141201)

Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons
D01D 5/24 (20130101)
D01D 5/30 (20130101)

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 8/00 (20130101)
D01F 8/10 (20130101)
D01F 8/14 (20130101) Original (OR) Class
D01F 8/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189620 Pourdeyhimi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
U.S. Air Force
APPLICANT(S) North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Behnam Pourdeyhimi (Raleigh, North Carolina);  Pierre Grondin (Raleigh, North Carolina);  Benoit Maze (Raleigh, North Carolina)
ABSTRACT Composites where nonwoven fabrics having multicomponent synthetic fibers with adhered particles thereon are disclosed. The multicomponent fibers have at least one polymer component with a melting point below that of the other components, and the average apparent particle diameter is less than the average apparent fiber diameter. Methods of making the disclosed composites are also disclosed.
FILED Friday, November 13, 2020
APPL NO 17/097868
CURRENT CPC
Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding
D04H 1/541 (20130101) Original (OR) Class
D04H 3/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189882 Hayes
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
United States Air Force (USAF)
APPLICANT(S) Special Aerospace Services, LLC (Boulder, Colorado)
ASSIGNEE(S) Special Aerospace Services, LLC (Boulder, Colorado)
INVENTOR(S) Christopher Hayes (Denver, Colorado)
ABSTRACT Methods and systems for manipulating surface topology of additively manufactured fluid interacting structures, such as additively manufactured heat exchangers or airfoils, and associated additively manufactured articles, are disclosed. In one aspect, an article which interacts with a fluid is imparted with surface topology features which affect performance parameters related to the fluid flow. The topological features may be sequenced, combined, intermixed, and functionally varied in size and form to locally manipulate and co-optimize multiple performance parameters at each or selectable differential lengths along a flow path. The co-optimization method may uniquely prioritize selectable performance parameters at different points along the flow path to improve or enhance overall system performance. Topological features may include design features such as dimples, fins, boundary layer disruptors, and biomimicry surface textures, and manufacturing artefacts such as surface roughness and subsurface porosity distribution and morphology.
FILED Tuesday, December 22, 2020
APPL NO 17/130916
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/14 (20130101) Original (OR) Class

Jet-propulsion Plants
F02K 9/60 (20130101)

Electric Digital Data Processing
G06F 30/15 (20200101)
G06F 30/28 (20200101)
G06F 2113/10 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189969 McCaffrey
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
APPLICANT(S) Raytheon Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S) Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S) Michael G. McCaffrey (Windsor, Connecticut)
ABSTRACT An interface for a gas turbine engine. The interface includes a full-hoop vane ring around the engine axis, the full-hoop vane ring comprises a forward vane rail with a vane ring forward contact surface and a vane ring anti-rotation tab, the vane ring anti-rotation tab engaged with the anti-rotation case slot; and a multiple of BOAS segments around the engine axis, each of the multiple of BOAS segments comprise a BOAS aft engagement feature and a BOAS aft contact surface, the BOAS aft engagement feature engaged with the outer case and the anti-rotation case slot, the BOAS aft contact surface abuts the vane ring forward contact surface.
FILED Wednesday, February 10, 2021
APPL NO 17/172858
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 11/122 (20130101)
F01D 25/24 (20130101)

Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants
F02C 7/28 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2240/55 (20130101)
F05D 2260/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190047 Swanson
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Information Warfare Center (NIWC)
Secretary of the Navy (SECNAV)
APPLICANT(S) Naval Information Warfare Center, Pacific (San Diego, California)
ASSIGNEE(S) United States of America as represented by Secretary of the Navy (San Diego, California)
INVENTOR(S) Paul D. Swanson (Santee, California)
ABSTRACT A propulsion system involving a boost feature comprising a stationary electrical conductor, the boost feature configured to couple with a combustion engine, the stationary electrical conductor disposed in a path of a moving high-velocity plasma of exhaust from the combustion engine, and the stationary electrical conductor electrically biased, whereby the moving high-velocity plasma is accelerated, and whereby propulsion is boosted.
FILED Monday, December 23, 2019
APPL NO 16/724834
CURRENT CPC
Producing a Reactive Propulsive Thrust, Not Otherwise Provided for
F03H 1/0006 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190062 Adamo et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
APPLICANT(S) Zaiput Flow Technologies LLC (Waltham, Massachusetts)
ASSIGNEE(S) Zaiput Flow Technologies LLC (Waltham, Massachusetts)
INVENTOR(S) Andrea Adamo (Cambridge, Massachusetts);  Kevin Sheehan (Waltham, Massachusetts)
ABSTRACT Liquid pumps and related systems and methods are generally described.
FILED Tuesday, October 20, 2020
APPL NO 17/074846
CURRENT CPC
Positive-displacement Machines for Liquids; Pumps
F04B 43/02 (20130101) Original (OR) Class
F04B 43/0054 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190434 Johnson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Secretary of the Air Force (SECAF)
APPLICANT(S) Government of the United States, as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S) Douglas J. Johnson (Kent, Ohio);  Nicholas P. Niedbalski (Springfield, Ohio);  Jamie S. Ervin (Springboro, Ohio);  Soumya S. Patnaik (Mason, Ohio)
ABSTRACT A thermal management system includes a slurry generator, an injector pump coupled to the slurry generator, a heat exchanger reactor coupled to the injector pump, wherein the heat exchanger reactor is adapted to subject a thermally expendable heat absorption material to a temperature above 60° C. and a pressure below 3 kPa, and wherein the expendable heat absorption material endothermically decomposes into a gaseous by-product. A vapor cycle system is coupled to the heat exchanger reactor and is operatively connected to a thermal load. A thermal energy storage system may be coupled to the vapor cycle system and the thermal load. The thermal energy storage system may isolate the heat exchanger reactor from thermal load transients of the thermal load.
FILED Tuesday, March 09, 2021
APPL NO 17/195683
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/423 (20130101)

Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact
F28D 15/06 (20130101)
F28D 15/0266 (20130101) Original (OR) Class
F28D 20/02 (20130101)
F28D 20/003 (20130101)
F28D 2021/0021 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190593 Yao et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S) Yu Yao (Chandler, Arizona);  Chao Wang (Chandler, Arizona);  Chu Wang (Mesa, Arizona);  Jing Bai (Tempe, Arizona);  Ali Basiri (Tempe, Arizona);  Xiahui Chen (Mesa, Arizona)
ABSTRACT A polarization sensor is described. It includes a quarter-wave plate to convert circularly polarized light into linearly polarized light. The quarter-wave plate is realized as a metasurface. The sensor also includes a linear polarizer to analyze the light generated by the quarter-wave plate, and a photodetector to receive the analyzed light. The sensor may be combined with other linear polarization sensors to form a sensor capable of complete measurement of the polarization state of incident light. An array of these sensors can be integrated directly onto image sensors to form a polarimetric imager.
FILED Friday, December 21, 2018
APPL NO 16/956988
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 4/04 (20130101) Original (OR) Class

Optical Elements, Systems, or Apparatus
G02B 5/3025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190597 Sanyal et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Surface Warfare Center (NSWC)
Secretary of the Navy (SECNAV)
APPLICANT(S) The United States of America, as represented by the Secretary of the Navy (Crane, Indiana)
ASSIGNEE(S) The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Subrata Sanyal (Eastvale, California);  Joseph A. Fiordilino (Corona, California)
ABSTRACT The present invention relates to a system for measuring the power of electromagnetic radiation (EMR) using piezoelectric transducers (PZTs) and pyroelectric transducers (PRTs). According to an illustrative embodiment of the present disclosure, a target cell has a mirrored surface that can partially reflect and partially absorb EMR. Each target cell can include or be coupled to PZTs and PRTs. When incident EMR reflects off of targets cells, the reflected portion creates radiation pressure and the non-reflected portions creates heat. The PZTs convert the pressure into a first electric current, and the PRTs convert the heat into a second electric current. Measuring the first and/or second currents allows a user to calculate the original power of an EMR source. By utilizing multiple target cells placed in specially designed arrays, a user can calculate fluctuations of EMR power by time and location across the target cells.
FILED Thursday, June 11, 2020
APPL NO 16/898694
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 5/34 (20130101) Original (OR) Class
G01J 2005/345 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190760 Adusumilli
FUNDED BY
Department of Defense (DOD)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S) MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
INVENTOR(S) Prasad S. Adusumilli (New York, New York)
ABSTRACT The present disclosure relates to methods, kits and systems for assessing cytotoxicity of immunoresponsive cells using a pleural effusion. The present disclosure also relates to methods, kits and systems for assessing effect of an immunotherapeutic agent on cytotoxicity of immunoresponsive cells using a pleural effusion.
FILED Friday, March 05, 2021
APPL NO 17/193367
CURRENT CPC
Peptides
C07K 14/7051 (20130101)
C07K 14/70521 (20130101)
C07K 16/30 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/505 (20130101) Original (OR) Class
G01N 2800/7004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191362 Nelaturi et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S)
INVENTOR(S) Saigopal Nelaturi (Mountain View, California);  Morad Behandish (Mountain View, California)
ABSTRACT Algorithmic reasoning about a cutting tool assembly's space of feasible configurations can be effectively harnessed to construct a sequence of motions that guarantees a collision-free path for the tool assembly to remove each support structure in the sequence. A greedy algorithm models the motion of the cutting tool assembly through the free-spaces around the intermediate shapes of the part as the free-spaces iteratively reduce in size to the near-net shape to determine feasible points of contact for the cutting tool assembly. Each support beam is evaluated for a contact feature along the boundary of the near-net shape that constitutes a feasible point of contact. If a support beam has at least one feasible configuration at each point, the support beam is deemed ‘accessible’ and a collection of tool assembly configurations that are guaranteed to be non-colliding but which can access all points of contact of each accessible support beam can be generated.
FILED Friday, February 12, 2021
APPL NO 17/174734
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/40 (20170801)
B29C 64/393 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 50/00 (20141201)
B33Y 50/02 (20141201)

Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 19/4099 (20130101) Original (OR) Class
G05B 2219/35012 (20130101)
G05B 2219/35134 (20130101)
G05B 2219/35204 (20130101)
G05B 2219/40519 (20130101)
G05B 2219/42155 (20130101)
G05B 2219/49007 (20130101)
G05B 2219/49012 (20130101)
G05B 2219/49038 (20130101)
G05B 2219/49041 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191503 KHAZANOVICH
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
APPLICANT(S) BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S) BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S) Roman KHAZANOVICH (Centereach, New York)
ABSTRACT The system and method of externally powered cold key load injects a voltage into a cryptographic computer without disturbing any data pins. There are several mechanical approaches that are viable, a Y cable implementation, a two cable solution, a direct connect solution, and more. The system includes the ability to provide a variable voltage power source to the cryptographic computer.
FILED Thursday, December 19, 2019
APPL NO 16/720130
CURRENT CPC
Electric Digital Data Processing
G06F 1/3296 (20130101) Original (OR) Class
G06F 13/4068 (20130101)
G06F 21/602 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191916 Medard et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Northeastern University (Boston, Massachusetts);  University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Muriel Medard (Belmont, Massachusetts);  Kishori Mohan Konwar (Revere, Massachusetts);  Prakash Narayana Moorthy (Hillsboro, Oregon);  Nancy Ann Lynch (Brookline, Massachusetts);  Erez Kantor (Brookline, Massachusetts);  Alexander Allister Schwarzmann (Storrs, Connecticut)
ABSTRACT Described are devices, systems and techniques for implementing atomic memory objects in a multi-writer, multi-reader setting. In an embodiment, the devices, systems and techniques use maximum distance separable (MDS) codes, and may be specifically designed to optimize a total storage cost for a given fault-tolerance requirement. Also described is an embodiment to handle the case where some of the servers can return erroneous coded elements during a read operation.
FILED Monday, November 23, 2020
APPL NO 17/101400
CURRENT CPC
Electric Digital Data Processing
G06F 3/067 (20130101)
G06F 16/00 (20190101)
G06F 16/27 (20190101)
G06F 16/2329 (20190101) Original (OR) Class

Transmission of Digital Information, e.g Telegraphic Communication
H04L 67/1097 (20130101)
H04L 69/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192018 BHUNIA et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) SWARUP BHUNIA (Gainesville, Florida);  MD MOSHIUR RAHMAN (Gainesville, Florida);  ABDULRAHMAN ALAQL (Gainesville, Florida)
ABSTRACT The present disclosure describes exemplary methods and systems of protecting an integrated circuit. One exemplary method comprises receiving a plurality of key inputs for enabling operation of the integrated circuit; determining whether the received key inputs are correct key inputs for enabling operation of the integrated circuit; and if the received key inputs are determined to be incorrect key inputs, locking sequential logic and combinational logic of the integrated circuit until correct key inputs are received.
FILED Monday, December 14, 2020
APPL NO 17/120778
CURRENT CPC
Electric Digital Data Processing
G06F 9/4498 (20180201)
G06F 21/14 (20130101) Original (OR) Class
G06F 21/602 (20130101)
G06F 30/327 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192105 Behandish, III et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S) Palo Alto Research Center Incorporated (Palo Alto, California)
INVENTOR(S) Morad Behandish, III (Mountain View, California);  Johan de Kleer (Los Altos, California);  Randi Wang (Cupertino, California)
ABSTRACT The techniques discussed herein generally relate to a method and system for qualitative modeling of and reasoning about the behavior of spatio-temporal physical systems. In some embodiments, qualitative representations based on Tonti diagrams are used to describe lumped or distributed parameter systems. Using a topological structure of the physical system, some embodiments generate qualitative governing equations as symbolic constraints on qualitative state variables. The qualitative constraints may be used to produce a qualitative simulation of the physical system. The qualitative simulation may be used to guide conceptual design iterations with given design criteria, or for instantiation of quantitative or hybrid (qualitative and quantitative) models and simulations.
FILED Monday, December 23, 2019
APPL NO 16/724983
CURRENT CPC
Electric Digital Data Processing
G06F 30/20 (20200101) Original (OR) Class
G06F 2111/04 (20200101)

Computer Systems Based on Specific Computational Models
G06N 5/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192113 NAM et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland);  IonQ, Inc. (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) Yunseong NAM (North Bethesda, Maryland);  Dmitri MASLOV (Falls Church, Virginia);  Andrew CHILDS (Bethesda, Maryland);  Neil Julien ROSS (Halifax, Canada);  Yuan SU (Hyattsville, Maryland)
ABSTRACT The disclosure describes the implementation of automated techniques for optimizing quantum circuits of the size and type expected in quantum computations that outperform classical computers. The disclosure shows how to handle continuous gate parameters and report a collection of fast algorithms capable of optimizing large-scale-scale quantum circuits. For the suite of benchmarks considered, the techniques described obtain substantial reductions in gate counts. In particular, the techniques in this disclosure provide better optimization in significantly less time than previous approaches, while making minimal structural changes so as to preserve the basic layout of the underlying quantum algorithms. The results provided by these techniques help bridge the gap between computations that can be run on existing quantum computing hardware and more advanced computations that are more challenging to implement in quantum computing hardware but are the ones that are expected to outperform what can be achieved with classical computers.
FILED Tuesday, February 02, 2021
APPL NO 17/165707
CURRENT CPC
Electric Digital Data Processing
G06F 30/39 (20200101)
G06F 30/327 (20200101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192302 Wang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Contracting Command (ACC)
APPLICANT(S) Advanced Functional Fabrics of America (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Tairan Wang (Chelmsford, Massachusetts);  Yoel Fink (Brookline, Massachusetts);  Carson Gee (Boston, Massachusetts);  Jason Cox (Ashland, Massachusetts);  Tosha Hays (Atlanta, Georgia);  Alexander Stolyarov (Belmont, Massachusetts);  Mihai Ibanescu (Somerville, Massachusetts)
ABSTRACT A fabric or article has a pattern on an exposed surface that encodes a unique identification code, wherein the pattern is configured to be read and decoded by a mobile computing device in a manner wherein the selected article is contextually recognizable. A two-dimensional plaid pattern may be used to carry the identification code, which can be decoded according to described methods. The pattern may be a plaid code or may be incorporated into a representational aesthetic environment. Fabrics may include optical transmitters embedded therein and configured to transmit information that can be detected by a mobile computing device, directed to the wearable article, and executing a suitable application. Fabrics may include optical receives configured to receive information such as from a free-space optical communication system of certain embodiments.
FILED Tuesday, December 01, 2020
APPL NO 17/109037
CURRENT CPC
Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 15/02 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 19/06028 (20130101)
G06K 19/06037 (20130101) Original (OR) Class
G06K 19/06103 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192330 Bilodeau et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey);  Universal Display Corporation (Ewing, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Simon Bilodeau (Princeton, New Jersey);  Paul Prucnal (Princeton, New Jersey);  Michael Hack (Ewing, New Jersey);  Thomas Ferreira de Lima (Princeton, New Jersey);  Hsuan-Tung Peng (Princeton, New Jersey);  Eric Blow (Princeton, New Jersey)
ABSTRACT A processing device comprises a plurality of artificial neurons comprising first and second artificial neurons, at least one optical connection between an optical output of the first artificial neuron and an optical input of the second artificial neuron, the optical input comprising a photosensitive element, at least one weighting element connected to the optical input of the second artificial neuron, configured to modify a gain of the optical input of the second artificial neuron, and at least one nonlinear element having an input and connected to the optical output of the first artificial neuron, configured to activate the optical output when a signal received at the input of the at least one nonlinear element rises above a threshold, wherein the optical output of the first artificial neuron comprises at least one thin film light-generating component. An LED neuron is also described.
FILED Thursday, December 17, 2020
APPL NO 17/125287
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)
G06N 3/067 (20130101) Original (OR) Class

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/288 (20130101)
H01L 27/3232 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192342 Hughes et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) Tyler William Hughes (Stanford, California);  Momchil Minkov (Stanford, California);  Ian Williamson (Stanford, California);  Shanhui Fan (Stanford, California)
ABSTRACT Systems and methods for training photonic neural networks in accordance with embodiments of the invention are illustrated. One embodiment includes a method for training a set of one or more optical interference units (OIUs) of a photonic artificial neural network (ANN), wherein the method includes calculating a loss for an original input to the photonic ANN, computing an adjoint input based on the calculated loss, measuring intensities for a set of one or more phase shifters in the set of OIUs when the computed adjoint input and the original input are interfered with each other within the set of OIUs, computing a gradient from the measured intensities, and tuning phase shifters of the OIU based on the computed gradient.
FILED Friday, May 10, 2019
APPL NO 17/054125
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/2935 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101) Original (OR) Class
G06N 3/063 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192363 Kolouri et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)
INVENTOR(S) Soheil Kolouri (Agoura Hills, California);  Mohammad Rostami (Los Angeles, California);  Praveen K. Pilly (West Hills, California)
ABSTRACT Described is a system for continual adaptation of a machine learning model implemented in an autonomous platform. The system adapts knowledge previously learned by the machine learning model for performance in a new domain. The system receives a consecutive sequence of new domains comprising new task data. The new task data and past learned tasks are forced to share a data distribution in an embedding space, resulting in a shared generative data distribution. The shared generative data distribution is used to generate a set of pseudo-data points for the past learned tasks. Each new domain is learned using both the set of pseudo-data points and the new task data. The machine learning model is updated using both the set of pseudo-data points and the new task data.
FILED Thursday, October 08, 2020
APPL NO 17/066457
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 5/022 (20130101) Original (OR) Class
G06N 20/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192379 Lee
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Information Warfare Center (NIWC)
Secretary of the Navy (SECNAV)
APPLICANT(S) Naval Information Warfare Center, Pacific (San Diego, California)
ASSIGNEE(S) United States of America as Represented by the Secretary of the Navy (San Diego, California)
INVENTOR(S) Dean-Yue Lee (San Diego, California)
ABSTRACT A computer-implemented method of improving maintenance of a complex system, the complex system having a plurality of components, the method involving: preparing data across a plurality of data streams from a plurality of data sources; generating a matrix representation of the data; calculating a time proximity of the data; calculating a plurality of corresponding cell values of the matrix representation; matching event information across the plurality of data streams from a plurality of data sources, the plurality of data sources corresponding to the plurality of components, wherein at least one data stream of the plurality of data streams has at least one of low fidelity data and imprecise event generation information; and scoring the imprecise event generation information across the plurality of data streams, thereby providing a score indicating a match quality of the imprecise event generation information.
FILED Monday, December 23, 2019
APPL NO 16/725833
CURRENT CPC
Electric Digital Data Processing
G06F 16/2282 (20190101)
G06F 16/9024 (20190101)

Computer Systems Based on Specific Computational Models
G06N 7/005 (20130101)
G06N 7/023 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192702 VOLANTE et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
APPLICANT(S) BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S) BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S) Jackson W. VOLANTE (Merrimack, New Hampshire);  Thomas E. NIELSON (Westford, Massachusetts);  Katharine S. STEER (Newmarket, New Hampshire)
ABSTRACT The system and method of frame differencing in high frame rate video to mitigate distortion caused by a bladed rotating assembly in the high frame rate video. The system and method applies one or more thresholds and a scaling factor and use a buffer of pixel values to mitigate distortions caused by blades as they pass in front of an imager.
FILED Thursday, December 19, 2019
APPL NO 16/720404
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6202 (20130101)

Image Data Processing or Generation, in General
G06T 1/60 (20130101)
G06T 3/40 (20130101)
G06T 5/002 (20130101)
G06T 5/30 (20130101) Original (OR) Class

Pictorial Communication, e.g Television
H04N 5/357 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193372 Montoya et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Information Warfare Center (NIWC)
Secretary of the Navy (SECNAV)
APPLICANT(S) The United States of America as Represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) Sergio A. Montoya (Chula Vista, California);  Benjamin J. Taylor (Escondido, California)
ABSTRACT An electronic package includes a mounting platform for mounting an electrically small device, at least one coil, and an insulator. The coil regulates a magnetic field through the electrically small device at the mounting platform. The coil is adapted to conduct a current for nullifying the magnetic field through the electrically small device at the mounting platform. The insulator is between the mounting platform and the coil for isolating the electrically small device from the coil. An electronic circuit includes this electronic package and the electrically small device mounted at the mounting platform of the electronic package. The electrically small device can be a quantum device and/or a topological device when cooled to a cryogenic temperature. The magnetic field is nullified to prevent the magnetic field from adversely affecting the electrically small device.
FILED Wednesday, December 18, 2019
APPL NO 16/718690
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/025 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 6/04 (20130101)
H01F 27/289 (20130101) Original (OR) Class
H01F 27/306 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193586 KHAZANOVICH et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
APPLICANT(S) BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S) BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S) Roman KHAZANOVICH (Centereach, New York);  David C. RINGLEN (Coram, New York)
ABSTRACT A Cryptographic System-in-Package (CSiP) including a built in TEMPEST shield surrounding the sides and the top of the device. In some cases the TEMPEST shield is metal and acts as a thermal path to conduct heat off of the CSiP. In some cases, the TEMPEST shield comprises a microscopic wire mesh and/or includes a power supply filter to block information leakage on the input voltage pins, a ball grid array (BGA) with ground encompassing the full perimeter the bottom of the package, and an encapsulation layer.
FILED Wednesday, December 18, 2019
APPL NO 16/718586
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 23/552 (20130101) Original (OR) Class
H01L 23/3107 (20130101)
H01L 23/49816 (20130101)
H01L 25/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193858 Cornfeld et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
United States Air Force (USAF)
APPLICANT(S) SolAero Technologies Corp. (Albuquerque, New Mexico)
ASSIGNEE(S) SolAero Technologies Corp. (Albuquerque, New Mexico)
INVENTOR(S) Arthur Cornfeld (Sandy Springs, Georgia);  Mark A. Stan (Albuquerque, New Mexico)
ABSTRACT A method of forming a multijunction solar cell that includes an InGaAs buffer layer and an InGaAlAs grading interlayer disposed below, and adjacent to, the InGaAs buffer layer. The grading interlayer achieves a transition in lattice constant from one solar subcell to another adjacent solar subcell.
FILED Friday, February 05, 2021
APPL NO 17/169223
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/06 (20130101) Original (OR) Class
H01L 31/184 (20130101)
H01L 31/0693 (20130101)
H01L 31/1844 (20130101)
H01L 31/03046 (20130101)
H01L 31/06875 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 10/544 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194177 Fang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Hui Fang (Brookline, Massachusetts);  Yi Qiang (Malden, Massachusetts);  Xun Han (Beijing, China PRC);  Kyung Jin Seo (Boston, Massachusetts)
ABSTRACT A soft neural interface connector apparatus includes a PCB having a two-dimensional array of solder balls, a transparent top board, a cushioning layer on one side of the transparent top board, and a soft neural interface including a flexible and/or stretchable microelectrode array (MEA) through which neural signals are obtained or delivered. The MEA includes a two-dimensional array of contact pads corresponding to the array of solder balls. The PCB, the transparent top board, the cushioning layer, and the MEA are stacked together such that the MEA is between the cushioning layer and the PCB, and the contact pads are aligned with and in electrical contact with associated solder balls. A magnetic connector system having at least one magnetic connector component on the transparent top board is magnetically connected with at least one magnetic connector component on the PCB to press the contact pads and associated solder balls together.
FILED Tuesday, November 24, 2020
APPL NO 17/103425
CURRENT CPC
Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors
H01R 12/79 (20130101)
H01R 12/85 (20130101)
H01R 13/6205 (20130101) Original (OR) Class
H01R 43/26 (20130101)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/18 (20130101)
H05K 1/118 (20130101)
H05K 2201/09063 (20130101)
H05K 2201/10189 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194620 James et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Information Warfare Center (NIWC)
Secretary of the Navy (SECNAV)
APPLICANT(S) Naval Information Warfare Center, Pacific (San Diego, California)
ASSIGNEE(S) United States of America as represented by Secretary of the Navy (San Diego, California)
INVENTOR(S) Justin O. James (San Diego, California);  Michael P. Daly (San Diego, California)
ABSTRACT A method and system are discussed for providing Unequal Error Protection (UEP) for heterogeneous multi-service provisioning. A transmitter in a network may determine a current status of the network. The transmitter may adaptively adjust a current asymmetric signal constellation and a current channel Forward Error Correction (FEC) coding rate based on the determined current status of the network, and initiate transmission of multi-service data, using the adaptively adjusted asymmetric signal constellation and the adaptively adjusted FEC coding rate for transmission of the multi-service data, based on hybrid Unequal Error Protection (UEP) transmission.
FILED Monday, December 23, 2019
APPL NO 16/724836
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 1/0003 (20130101)
H04L 1/007 (20130101) Original (OR) Class
H04L 1/0026 (20130101)
H04L 27/3405 (20130101)
H04L 2001/0098 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194905 Fong et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) Alexander Fong (San Francisco, California);  Xiaokui Shu (Ossining, New York);  Marc Philippe Stoecklin (White Plains, New York)
ABSTRACT An interactive display system enables a user to compose a graph pattern for a temporal graph on a display screen. The system comprises a canvas that provides an interactive editing surface. The editor receives an input a set of user interactions, such as the drawing of lines and boxes, the specifying of attributes, and the like, that together compose a graph pattern. During the graph pattern composition, the user may retrieve other graph patterns (e.g., from a data store) and integrate them into the pattern being composed. Once the graph pattern is composed (or as it is being composed), the system converts the graphical pattern into a text-based representation, such as a computer program in a particular graph programming language, which is then used for subsequent processing and matching in a cybersecurity threat discovery workflow. The pattern (program code) also is stored to disk, from which it may be retrieved and converted back into its graphical view on the screen, e.g., for further editing and revision.
FILED Monday, December 23, 2019
APPL NO 16/725207
CURRENT CPC
Electric Digital Data Processing
G06F 16/9024 (20190101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/1416 (20130101)
H04L 63/1425 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194928 Halford
FUNDED BY
Department of Defense (DOD)
United States Marine Corps (USMC)
Marine Corps Systems Command (MARCORSYSCOM)
APPLICANT(S) Caliola Engineering, LLC (Colorado Springs, Colorado)
ASSIGNEE(S) Caliola Engineering, LLC (Colorado Springs, Colorado)
INVENTOR(S) Thomas R. Halford (Colorado Springs, Colorado)
ABSTRACT A system and method for cryptographically securing data communications between a group of networked devices establishes and maintains an overlay network at the Application Layer, on top of a unicast routing service provided at the Internetworking Layer. The overlay network provides first, the routes that are used to deliver multicast datagrams and second, the cryptographic keys used to secure multicast datagrams. A common cryptographic key is established between all members of each group, and end-to-end encryption ensures that multicast datagrams can be accessed only by authorized group members. In other embodiments, keys are established between pairs of adjacent devices in the overlay network, and hop-by-hop encryption ensures that multicast datagrams can be accessed only by overlay network members.
FILED Thursday, June 04, 2020
APPL NO 16/892883
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/0841 (20130101)
H04L 63/065 (20130101)
H04L 63/168 (20130101) Original (OR) Class
H04L 63/0435 (20130101)
H04L 63/0464 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210195129 Pimpinella et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Sivananthan Laboratories, Inc. (Bolingbrook, Illinois)
ASSIGNEE(S) Sivananthan Laboratories, Inc. (Bolingbrook, Illinois)
INVENTOR(S) Richard Edward Pimpinella (Naperville, Illinois);  Anthony Joseph Ciani (Palatine, Illinois);  Christoph H. Grein (Wheaton, Illinois)
ABSTRACT A photodetector device is provided that includes a ROIC having a top surface with a plurality of electrically conductive first electrodes within a pattern of surface areas on the top surface each surface area having a border, and an electrically conductive electrode grid having a portion on the border of each of the surface areas; and a photodetector film overlying the surface area. The electrode grid can be configured to surround each surface area to define the borders of the surface areas as pixels. The photodetector film can be a colloidal quantum dot film. The ROIC has circuit elements signal-connected to the plurality of first electrodes. Methods for forming the photodetector device include photolithography and deposition methods.
FILED Monday, December 23, 2019
APPL NO 16/726047
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/14645 (20130101)
H01L 31/035218 (20130101)

Pictorial Communication, e.g Television
H04N 5/378 (20130101) Original (OR) Class
H04N 5/3745 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210195306 Brown
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Surface Warfare Center (NSWC)
Secretary of the Navy (SECNAV)
APPLICANT(S) The United States of America, as represented by the Secretary of the Navy (Crane, Indiana)
ASSIGNEE(S) The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Christopher A. Brown (Bloomington, Indiana)
ABSTRACT The present invention relates to a communication disruption system. In a first audio path, a microphone receives input sound, an amplifier system amplifies the sound, and a sound system transmits a first output sound. In a second audio path, the microphone receives input sound, a delay circuit delays the sound, the amplifier system amplifies the sound, and the sound system transmits a second output sound. A target speaker will hear the first and second output sounds, with the first output sound being a reproduction of their speech heard nearly simultaneously with the original speech, and the second output sound being a reproduction of their speech heard slightly after the original speech. Due to the delayed auditory feedback effect, the target speaker's concentration will be disrupted, making it difficult for them to continue speaking.
FILED Wednesday, December 18, 2019
APPL NO 16/718783
CURRENT CPC
Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 1/04 (20130101) Original (OR) Class
H04R 3/04 (20130101)
H04R 29/004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20210187091 HAYNES et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Laboratory (LANL)
Los Alamos National Security, LLC (LANS)
APPLICANT(S) Duke University (Durham, North Carolina);  Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Barton F. HAYNES (Durham, North Carolina);  Mattia BONSIGNORI (Durham, North Carolina);  Bette T. KORBER (Los Alamos, New Mexico);  Peter T. HRABER (Los Alamos, New Mexico);  Kevin SAUNDERS (Durham, North Carolina)
ABSTRACT In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
FILED Friday, March 03, 2017
APPL NO 16/081771
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101) Original (OR) Class
A61K 2039/55555 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187095 RIEDER et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
Department of Agriculture (USDA)
APPLICANT(S) LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (LIVERMORE, California);  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (WASHINGTON, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Aida E. RIEDER (Westbrook, Connecticut);  Teresa B. DE LOS SANTOS (Miller Place, New York);  Luis L. RODRIGUEZ (Clinton, Connecticut);  Devendra RAI (Old Saybrook, Connecticut);  Fayna C. DIAZ-SAN SEGUNDO (Ronkonkoma, New York);  Paul D. HOEPRICH (Pleasanton, California)
ABSTRACT Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.
FILED Tuesday, February 16, 2021
APPL NO 17/176989
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/135 (20130101) Original (OR) Class
A61K 2039/55566 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2770/32122 (20130101)
C12N 2770/32134 (20130101)
C12N 2770/32141 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/70 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/53 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187279 Bouton et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
APPLICANT(S) Battelle Memorial Institute (Columbus, Ohio)
ASSIGNEE(S) Battelle Memorial Institute (, None)
INVENTOR(S) Chad E. Bouton (Powell, Ohio);  Jeffrey Friend (Columbus, Ohio)
ABSTRACT The present disclosure describes systems, methods, devices for performing thought-controlled neuromuscular stimulation. Also described are methods for producing a neuromuscular stimulation cuff. The systems and methods generally relate to receiving and processing thought signals indicative of an intended action, and then delivering stimulation to effectuate the intended action through a neuromuscular stimulation cuff. The neuromuscular stimulation cuff includes a flexible printed circuit board having at least one finger and a plurality of electrogel discs disposed on the at least one finger. The neuromuscular stimulation cuff may be produced by providing a layer of polyimide, etching a conductive copper circuit including a plurality of electrodes into the layer of polyimide to form an etched circuit layer, adhering a cover layer onto the etched circuit layer to form a flexible printed circuit board (PCB), and cutting at least one finger from the flexible PCB. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
FILED Tuesday, March 09, 2021
APPL NO 17/196082
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/0452 (20130101)
A61N 1/0456 (20130101)
A61N 1/0476 (20130101)
A61N 1/0484 (20130101) Original (OR) Class
A61N 1/0492 (20130101)
A61N 1/36003 (20130101)
A61N 1/36031 (20170801)
A61N 1/36034 (20170801)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 3/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187442 Ardo et al.
FUNDED BY
Department of Energy (DOE)
Joint Center for Artificial Photosynthesis (JCAP)
Lawrence Berkeley National Laboratory (LBNL)
Office of Science (DOEOS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Shane Ardo (Irvine, California);  Gideon Segev (Berkeley, California);  Francesca Toma (Berkeley, California);  Joel Ager (Berkeley, California);  Rylan Kautz (Irvine, California);  David Larson (Berkeley, California)
ABSTRACT Described herein is an ion pump system implementing an electronic ratchet mechanism produced by modulating a spatially varying electric potential distribution that can result in a net ionic current and voltage. The ion pumping membrane system includes an ion-permeable layer that can also be integrated with ion-selective membranes. The electric potential distribution within the ion-permeable layer is modulated through external stimuli. When immersed in solution, ions within the ion-permeable layer experience a time varying, spatially asymmetric electric field distribution resulting in ratchet-driven direct ion pumping, which can be used in applications such as desalination.
FILED Thursday, December 17, 2020
APPL NO 17/125341
CURRENT CPC
Separation
B01D 61/46 (20130101) Original (OR) Class
B01D 61/445 (20130101)
B01D 2311/2684 (20130101)
B01D 2325/26 (20130101)
B01D 2325/42 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187646 Byers et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Science Foundation (NSF)
APPLICANT(S) HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
ASSIGNEE(S) HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
INVENTOR(S) Kyle J. Byers (Kansas City, Missouri);  Daniel Scott Krueger (Liberty, Missouri);  Michael Walsh (Overland Park, Kansas);  William Price (Easton, Kansas)
ABSTRACT A method of manufacturing a compound object, such as an antenna, is disclosed. The method includes creating, via additive manufacturing, a first component formed at least in part of an oxidizing metal; applying, via vapor deposition, a solderable coating to at least a portion of the first component; and soldering at least a portion of the first component to a second component by applying a solder to the solderable coating of the first component. The oxidizing metal may be a titanium allow, such as Ti-6Al-4V. The solderable coating may include copper and/or tin-lead.
FILED Thursday, December 19, 2019
APPL NO 16/720445
CURRENT CPC
Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam
B23K 1/0008 (20130101)
B23K 1/20 (20130101) Original (OR) Class
B23K 2103/14 (20180801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 70/00 (20141201)

Alloys
C22C 14/00 (20130101)

Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187860 Mitchell
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) John A. Mitchell (Albuquerque, New Mexico)
ABSTRACT A method and apparatus for identifying porosity in a structure made by an additive manufacturing process in which a laser is scanned across layers of material to form the structure. Pyrometry data comprising images of the layers acquired during additive manufacturing of the structure is received. The pyrometry data is used to generate temperature data comprising estimated temperatures of points in the layers in the images of the layers. The temperature data is used to identify shapes fit to high temperature areas in the images of the layers. Conditions of the shapes fit to the high temperature areas in the images of the layers are identified. Outlier shapes are identified in the shapes fit to the high temperature areas in the images of the layers using the conditions of the shapes.
FILED Thursday, March 12, 2020
APPL NO 16/817340
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/393 (20170801) Original (OR) Class

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 50/02 (20141201)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/088 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188074 Correa
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) CUMMINS INC. (Columbus, Indiana)
ASSIGNEE(S) CUMMINS INC. (Columbus, Indiana)
INVENTOR(S) Dixon Malcolm Correa (Columbus, Indiana)
ABSTRACT An energy recovery drive system includes a motor-generator that is structured to selectively operate in a motor mode and a generator mode. A first shaft is operatively coupled to a transmission power take-off shaft. A second shaft is operatively coupled to the motor-generator and to an alternative power source. The energy recovery drive system is controllably operated in a plurality of operating modes. In a first operating mode, the motor-generator is in torque providing engagement with each of the first and second shafts. In a second operating mode, the motor-generator is in torque communicating engagement with each of the first and second shafts. In a third operating mode, which the motor-generator is in torque communicating engagement with the second shaft and is disengaged from transferring torque to the first shaft and from receiving torque from the first shaft.
FILED Friday, February 12, 2021
APPL NO 17/175104
CURRENT CPC
Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles
B60K 6/48 (20130101)
B60K 6/387 (20130101) Original (OR) Class
B60K 6/547 (20130101)
B60K 25/06 (20130101)
B60K 2006/4808 (20130101)

Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles
B60L 7/10 (20130101)
B60L 50/15 (20190201)
B60L 2260/24 (20130101)

Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit
B60W 20/11 (20160101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188106 Asa et al.
FUNDED BY
Department of Energy (DOE)
Pacific Northwest National Laboratory (PNNL)
UT-Battelle, LLC (UT-BATTELLE)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Erdem Asa (Oak Ridge, Tennessee);  Veda Prakash Galigekere (Oak Ridge, Tennessee);  Omer C. Onar (Oak Ridge, Tennessee);  Burak Ozpineci (Oak Ridge, Tennessee);  Jason L. Pries (Oak Ridge, Tennessee);  Gui-Jia Su (Oak Ridge, Tennessee)
ABSTRACT A method for wirelessly or conductively (non-wireless) providing AC or DC power in AC or DC load applications and bidirectional applications.
FILED Friday, December 18, 2020
APPL NO 17/127197
CURRENT CPC
Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles
B60L 53/60 (20190201)
B60L 53/122 (20190201) Original (OR) Class
B60L 2210/20 (20130101)
B60L 2210/30 (20130101)

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 7/0047 (20130101)
H02J 50/12 (20160201)
H02J 50/80 (20160201)
H02J 2310/48 (20200101)

Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof
H02M 5/293 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188246 Li et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Cummins Inc. (Columbus, Indiana)
ASSIGNEE(S)
INVENTOR(S) Ke Li (Columbus, Indiana);  Kenneth M. Follen (Greenwood, Indiana);  John P. Kresse (Martinsville, Indiana)
ABSTRACT A controls system for a range-extended electric vehicle comprising an overall system control unit, an engine control module configured to control a range extender of the range-extended electric vehicle, power electronics configured to control a generator of the range-extended electric vehicle, and a supervisory control module coupled between the overall system control unit and the engine control module and the power electronics, the supervisory control module configured to receive information from the overall system control unit and provide commands to the engine control module and the power electronics.
FILED Friday, December 18, 2020
APPL NO 17/127057
CURRENT CPC
Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit
B60W 10/06 (20130101)
B60W 10/08 (20130101)
B60W 20/15 (20160101) Original (OR) Class
B60W 40/08 (20130101)
B60W 50/0205 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188636 Ambrosini et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
Sandia National Laboratories (SNL)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico);  Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Andrea Ambrosini (Albuquerque, New Mexico);  James E. Miller (Albuquerque, New Mexico);  Ellen B. Stechel (Albuquerque, New Mexico)
ABSTRACT The present disclosure is directed to renewable pathways to nitrogen production and ammonia (NH3) synthesis that utilize renewable heat as process heat instead of fossil fuels and operates at low to medium pressures (from 0.2-3 MPa). The renewable pathways result in both a decrease or elimination of greenhouse gas emissions as well as avoid the cost, complexity and safety issues inherent in high-pressure processes. Renewable thermochemical looping technology is used that produces nitrogen from air for the subsequent production of ammonia via an advanced two-stage process.
FILED Friday, December 18, 2020
APPL NO 17/127444
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 21/02 (20130101)
C01B 21/0422 (20130101) Original (OR) Class

Ammonia; Cyanogen; Compounds Thereof
C01C 1/026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188654 O'Hara et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
Pacific Northwest National Laboratory (PNNL)
APPLICANT(S) BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
ASSIGNEE(S) BATTELLE MEMORIAL INSTITUTE (Richland, Washington)
INVENTOR(S) Matthew J. O'Hara (Richland, Washington);  Gabriel B. Hall (Richland, Washington);  Lucas P. Boron-Brenner (Richland, Washington)
ABSTRACT Systems and/or methods for producing free elements, systems and/or methods for producing element storage/generation vessel assemblies, element storage/generation vessel assemblies, system and/or methods for purifying elements and providing a progeny generating assemblies are provided.
FILED Friday, December 11, 2020
APPL NO 17/120084
CURRENT CPC
Separation
B01D 15/10 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/20 (20130101)

Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals
C01F 13/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188671 Sant et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Gaurav Sant (Los Angeles, California);  Zongsu Wei (Los Angeles, California);  Bu Wang (Los Angeles, California);  Erika Callagon La Plante (Los Angeles, California);  Dante Simonetti (Los Angeles, California)
ABSTRACT A method includes: (1) using a chelating agent, extracting divalent ions from a brine solution as complexes of the chelating agent and the divalent ions; (2) using a weak acid, regenerating the chelating agent and producing a divalent ion salt solution; and (3) introducing carbon dioxide to the divalent ion salt solution to induce precipitation of the divalent ions as a carbonate salt. Another method includes: (1) combining water with carbon dioxide to produce a carbon dioxide solution; (2) introducing an ion exchanger to the carbon dioxide solution to induce exchange of alkali metal cations included in the ion exchanger with protons included in the carbon dioxide solution and to produce a bicarbonate salt solution of the alkali metal cations; and (3) introducing a brine solution to the bicarbonate salt solution to induce precipitation of divalent ions from the brine solution as a carbonate salt.
FILED Friday, February 26, 2021
APPL NO 17/187252
CURRENT CPC
Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium
C01D 7/12 (20130101)
C01D 7/16 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/442 (20130101)
C02F 1/444 (20130101)
C02F 1/683 (20130101) Original (OR) Class
C02F 2103/08 (20130101)
C02F 2305/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188734 VARDON et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Derek Richard VARDON (Lakewood, Colorado);  Xiangchen HUO (Golden, Colorado);  Nabila HUQ (Golden, Colorado);  Huong Thi Thanh Nguyen (Arvada, Colorado)
ABSTRACT The present disclosure relates to a method that includes a first treating of a first mixture that includes a carboxylic acid having between 2 and 12 carbon atoms, inclusively, to form a second mixture that includes a ketone having between 2 and 25 carbon atoms, inclusively, and a second treating of at least a first portion of the second mixture to form a first product that includes a paraffin having 8 or more carbon atoms.
FILED Monday, December 14, 2020
APPL NO 17/121336
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 1/22 (20130101) Original (OR) Class
C07C 9/15 (20130101)
C07C 9/16 (20130101)
C07C 45/41 (20130101)
C07C 45/68 (20130101)

Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters
C10L 1/04 (20130101)
C10L 2200/0469 (20130101)
C10L 2270/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189012 Mao et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S)
INVENTOR(S) Chuanbin Mao (Norman, Oklahoma);  Lin Wang (Norman, Oklahoma);  Penghe Qiu (Norman, Oklahoma)
ABSTRACT A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide.
FILED Thursday, April 02, 2020
APPL NO 16/838798
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/0011 (20130101)
A61K 39/39 (20130101)
A61K 39/385 (20130101)
A61K 2039/60 (20130101)
A61K 2039/627 (20130101)
A61K 2039/645 (20130101)
A61K 2039/55561 (20130101)

Peptides
C07K 17/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189187 Hun et al.
FUNDED BY
Department of Energy (DOE)
Pacific Northwest National Laboratory (PNNL)
UT-Battelle, LLC (UT-BATTELLE)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee);  University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Diana Hun (Lenoir City, Tennessee);  Pengfei Cao (Knoxville, Tennessee);  Tomonori Saito (Knoxville, Tennessee);  Zhen Zhang (Knoxville, Tennessee);  Bingrui Li (Knoxville, Tennessee);  Natasha Ghezawi (Rock Top, Tennessee)
ABSTRACT A self-healing adhesive composition comprising a homogeneous mixture of: (i) a self-healing polymer containing hydrogen bonding groups or long-chain alkyl groups, wherein said hydrogen bonding groups comprise hydrogen bond donating groups and hydrogen bond accepting groups, and wherein said long-chain alkyl groups contain at least four carbon atoms; and (ii) an extrudable adhesive polymer base having a curable property and no self-healable property; wherein component (i) is present in the self-healing adhesive composition in an amount of at least 10 wt % and up to 70 wt % of the total of components (i) and (ii). Also described herein is a method of sealing a space (e.g., crack, gap, or pores) in a substrate material by at least partially filling the space with the self-healing adhesive composition described above and permitting the self-healing adhesive composition to harden over time without applying an external stimulus to induce hardening.
FILED Thursday, December 10, 2020
APPL NO 17/117827
CURRENT CPC
Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 220/343 (20200201)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/315 (20130101)

Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives
C09J 7/30 (20180101) Original (OR) Class
C09J 2433/00 (20130101)
C09J 2475/00 (20130101)
C09J 2483/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189574 REN et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas)
ASSIGNEE(S) University of Houston System (Houston, Texas)
INVENTOR(S) Zhifeng REN (Pearland, Texas);  Fang YU (Houston, Texas);  Haiqing ZHOU (Houston, Texas);  Shuo CHEN (Houston, Texas)
ABSTRACT A method of manufacturing a bifunctional electrocatalyst for overall water splitting comprising oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) by growing electrocatalyst comprising primarily metallic phosphides on a three-dimensional substrate by: immersing the substrate in an iron nitrate solution to form a once disposed substrate; subjecting the once disposed substrate to thermal phosphidation with phosphorus powder under inert gas to grow metal phosphides thereupon and form a once subjected substrate; cooling the once subjected substrate to form a cooled, once subjected substrate; immersing the cooled, once subjected substrate in an iron nitrate solution to form a twice disposed substrate; and subjecting the twice disposed substrate to thermal phosphidation with phosphorus powder under inert gas to provide an electrode comprising the bifunctional electrocatalyst on the three-dimensional substrate.
FILED Wednesday, April 10, 2019
APPL NO 17/047032
CURRENT CPC
Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 1/04 (20130101)
C25B 11/061 (20210101)
C25B 11/075 (20210101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189581 Li et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S) Qiang Li (Ames, Iowa);  Xinghang Zhang (West Lafayette, Indiana);  Haiyan Wang (West Lafayette, Indiana);  Jie Ding (West Lafayette, Indiana)
ABSTRACT A high-strength coatings and methods of fabrication to yield single-crystal-like nickel containing nanotwins and stacking faults.
FILED Tuesday, June 25, 2019
APPL NO 17/058246
CURRENT CPC
Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 15/01 (20130101)
B32B 15/20 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/165 (20130101)
C23C 28/023 (20130101)

Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor
C25D 3/18 (20130101) Original (OR) Class
C25D 5/18 (20130101)

Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 7/12 (20130101)
C30B 29/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189866 Kemp et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
Sandia National Laboratories (SNL)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico);  UNM Rainforest Innovations (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Richard A. Kemp (Albuquerque, New Mexico);  Timothy J. Boyle (Albuquerque, New Mexico)
ABSTRACT The present invention relates to modified proppants and methods of using the modified proppants that use metal ligand tracers to characterize subterranean fluid flow. The metal and ligands are best chosen to be a strongly-coordinating, chelating ligand with a functional group for the chosen flow environment.
FILED Thursday, December 10, 2020
APPL NO 17/118074
CURRENT CPC
Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 47/045 (20130101)

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/267 (20130101)
E21B 47/11 (20200501) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190245 KASHY
FUNDED BY
Department of Energy (DOE)
Pacific Northwest National Laboratory (PNNL)
Thomas Jefferson National Accelerator Facility (TJNAF)
APPLICANT(S) JEFFERSON SCIENCE ASSOCIATES, LLC (Newport News, Virginia)
ASSIGNEE(S)
INVENTOR(S) DAVID KASHY (Newport News, Virginia)
ABSTRACT A pipe coupling system including a pair of tubular flange halves and a plurality of clamp segments. A seal resides in a groove on the flange face. The tube mating ends are secured to the pipe or tubing. The flange halves are then drawn together and the seal is compressed. The clamp segments are placed around the periphery of the joined flanges. The pipe coupling system advantageously separates the functions of squeezing the seal from tightening the flanges, minimizes the total space required for achieving a seal, is easily disassembled and reassembled without causing significant process downtime, minimizes the radial space needed beyond the outer diameter of the pipe, and effectively seals against leakage of vacuum, liquid, or gas.
FILED Saturday, December 21, 2019
APPL NO 16/724238
CURRENT CPC
Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General
F16L 23/003 (20130101)
F16L 23/036 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190648 Dark
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Science Foundation (NSF)
APPLICANT(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S) Phillip Ryan Dark (Kansas City, Kansas)
ABSTRACT An apparatus for simulating an oscillating flight path is provided. The apparatus comprises a slide extending along a first axis; a support structure slidably coupled to the slide; and a table connected to the support structure. The support structure is operable to move along the slide. The table is coupled to the support structure and operable to rotate about a second axis orthogonal to the first axis. The table comprises a surface that is parallel to the second axis and that is operable to rotate about a third axis orthogonal to the second axis.
FILED Wednesday, December 16, 2020
APPL NO 17/123290
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/28 (20130101) Original (OR) Class
G01N 2001/002 (20130101)
G01N 2001/2893 (20130101)

Electric Digital Data Processing
G06F 16/901 (20190101)

Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils
H02P 29/40 (20160201)
H02P 29/60 (20160201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190753 Deng et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
Pacific Northwest National Laboratory (PNNL)
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Z. Daniel Deng (Richland, Washington);  Mitchell J. Myjak (Richland, Washington);  Jun Lu (Richland, Washington);  Jayson J. Martinez (Richland, Washington);  Chuan Tian (Richland, Washington);  Thomas J. Carlson (Holmes Beach, Florida);  Scott J. Morris (Kennewick, Washington);  Hongfei Hou (Richland, Washington)
ABSTRACT An improved sensor fish with robust design and enhanced measurement capabilities. This sensor fish contains sensors for acceleration, rotation, magnetic field intensity, pressure, and temperature. A low-power microcontroller collects data from the sensors and stores up to 5 minutes of data on a non-volatile flash memory. A rechargeable battery supplies power to the sensor fish. A recovery system helps locating sensor fish. The package, when ready for use is nearly neutrally buoyant and thus mimics the behavior of an actual fish.
FILED Thursday, February 11, 2021
APPL NO 17/174257
CURRENT CPC
Hydraulic Engineering
E02B 8/085 (20130101)

Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry
G01C 13/002 (20130101)

Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume
G01F 22/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/1886 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190757 Chang et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Baisong Chang (Wuhan, China PRC);  Zhen Cheng (Stanford, California)
ABSTRACT The disclosure provides NIR-II phosphorescent imaging probe and methods of using the NIR-II phosphorescent imaging probes for imaging tissues, such as cancerous tissues. NIR-II phosphorescent imaging probes of the present disclosure include CuInX2 nanotubes, where X is a chalcogen selected from S, Se, and Te, such as CuInSe2 nanotube.
FILED Friday, December 18, 2020
APPL NO 17/127661
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6486 (20130101)
G01N 33/4833 (20130101) Original (OR) Class
G01N 2800/7028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190819 Pooser et al.
FUNDED BY
Department of Energy (DOE)
Pacific Northwest National Laboratory (PNNL)
UT-Battelle, LLC (UT-BATTELLE)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Raphael C. Pooser (Oak Ridge, Tennessee);  Benjamin J. Lawrie (Oak Ridge, Tennessee);  Petro Maksymovych (Oak Ridge, Tennessee)
ABSTRACT A truncated non-linear interferometer-based atomic force microscope (AFM) includes an input port and a non-linear amplifier that renders a probe beam and a conjugate beam. The AFM includes local oscillators having a relationship with the probe beam and the conjugate beam. The displacement of the AFM's cantilever is transduced by the probe beam, and/or the conjugate beam or their respective local oscillators. The AFM's phase-sensitive detectors detect a phase modulation between the respective local oscillators and the probe beam and the conjugate beam. The detected phase modulation corresponds to the change in phase. The AFM's circuitry measures phase signals that are indicative of the cantilever displacement. The resulting measurement signals exhibit a quantum noise reduction in either the intensity difference or phase sum quadrature.
FILED Wednesday, December 18, 2019
APPL NO 16/719437
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 35/00 (20130101)

Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM]
G01Q 60/36 (20130101)
G01Q 60/38 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191620 SEYEDZADEHDELCHEH et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
Lawrence Livermore National Laboratory (LLNL)
APPLICANT(S) ADVANCED MICRO DEVICES, INC. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) SeyedMohammad SEYEDZADEHDELCHEH (Bellevue, Washington);  Xianwei ZHANG (Austin, Texas);  Bradford BECKMANN (Bellevue, Washington);  Shomit N. DAS (Austin, Texas)
ABSTRACT In some embodiments, a memory controller in a processor includes a base value cache, a compressor, and a metadata cache. The compressor is coupled to the base value cache and the metadata cache. The compressor compresses a data block using at least a base value and delta values. The compressor determines whether the size of the data block exceeds a data block threshold value. Based on the determination of whether the size of the compressed data block generated by the compressor exceeds the data block threshold value, the memory controller transfers only a set of the compressed delta values to memory for storage. A decompressor located in the lower level cache of the processor decompresses the compressed data block using the base value stored in the base value cache, metadata stored in the metadata cache and the delta values stored in memory.
FILED Monday, December 23, 2019
APPL NO 16/724609
CURRENT CPC
Electric Digital Data Processing
G06F 3/064 (20130101)
G06F 3/0608 (20130101) Original (OR) Class
G06F 3/0659 (20130101)
G06F 3/0673 (20130101)
G06F 12/0875 (20130101)
G06F 2212/1044 (20130101)

Image Data Processing or Generation, in General
G06T 1/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191727 Jacob et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) Philip Jacob (Congers, New York);  Philip Neil Strenski (Yorktown Heights, New York);  Charles Johns (Austin, Texas)
ABSTRACT A system and method for notifying a process about a creation or removal event of a named data element (NDE) in a coordination namespace distributed memory system. A controller runs methods to: generate a tuple corresponding to data generated by a requesting process, the tuple having a tuple name and data value; and generate a notification indicator in a pending notification list to indicate to one or more processes a notification of the creation or removal event associated with the corresponding tuple. Upon detecting the event performed on the tuple by a second process, the method further searches for NDEs in the distributed memory system having the same tuple name, and in response to determining an existence of an associated pending notification record in a pending notification list of records, notify each corresponding process of the one or more processes indicated in the list of the creation or removal event.
FILED Wednesday, December 18, 2019
APPL NO 16/719397
CURRENT CPC
Electric Digital Data Processing
G06F 9/3838 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191797 SeyedzadehDelcheh et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
Lawrence Livermore National Laboratory (LLNL)
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) SeyedMohammad SeyedzadehDelcheh (Bellevue, Washington);  Steven Raasch (Boxborough, Massachusetts)
ABSTRACT A method includes receiving a write request for writing incoming data to a target memory line and, in response to the write request, comparing the incoming data with existing data in the target memory line to determine a number of a first type of state transition. The method further includes, in response to determining that the number of the first type of state transition for the write request exceeds a threshold, prior to writing the incoming data to the target memory line, storing adjacent data from each of a set of memory lines adjacent to the target memory line, and after writing the incoming data to the target memory line, writing the stored data to the set of adjacent memory lines.
FILED Friday, December 20, 2019
APPL NO 16/723855
CURRENT CPC
Electric Digital Data Processing
G06F 9/30101 (20130101)
G06F 11/076 (20130101) Original (OR) Class
G06F 11/1044 (20130101)
G06F 13/1668 (20130101)

Static Stores
G11C 11/409 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191869 SeyedzadehDelcheh et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
Lawrence Livermore National Laboratory (LLNL)
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) SeyedMohammad SeyedzadehDelcheh (Bellevue, Washington);  Shomit N. Das (Austin, Texas);  Bradford Michael Beckmann (Redmond, Washington)
ABSTRACT Systems, apparatuses, and methods for implementing a multi-tiered approach to cache compression are disclosed. A cache includes a cache controller, light compressor, and heavy compressor. The decision on which compressor to use for compressing cache lines is made based on certain resource availability such as cache capacity or memory bandwidth. This allows the cache to opportunistically use complex algorithms for compression while limiting the adverse effects of high decompression latency on system performance. To address the above issue, the proposed design takes advantage of the heavy compressors for effectively reducing memory bandwidth in high bandwidth memory (HBM) interfaces as long as they do not sacrifice system performance. Accordingly, the cache combines light and heavy compressors with a decision-making unit to achieve reduced off-chip memory traffic without sacrificing system performance.
FILED Monday, December 23, 2019
APPL NO 16/725971
CURRENT CPC
Electric Digital Data Processing
G06F 11/3037 (20130101)
G06F 12/0246 (20130101)
G06F 12/0871 (20130101) Original (OR) Class
G06F 12/0897 (20130101)
G06F 2212/401 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191914 Jacob et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) Philip Jacob (Congers, New York);  Philip Neil Strenski (Yorktown Heights, New York);  Charles Johns (Austin, Texas)
ABSTRACT A system and method for supporting tuple record interlinking in one or more tuple space/coordinated namespace (CNS) extended memory storage systems. A system-wide CNS provides for efficient storing and communicating of data generated by local processes running at the nodes, and coordinated to generate a union/intersection of multiple CNS where tuple records are interlinked in multiple CNS hashtables, and/or share tuple data between two sets of processes that are part of different CNSs. Local node processes further generate multi-key tuples where two or more tuple records are interlinked within the same CNS hash table, thereby permitting a look up of the tuple data by either tuple name/keys. A CNS controller further provides a tuple iterator for a key-value storage in a CNS system that adds more links between tuples enables creation of iterator structures such as linked list or trees etc. of “different” tuples in a tuple database.
FILED Wednesday, December 18, 2019
APPL NO 16/719340
CURRENT CPC
Electric Digital Data Processing
G06F 9/546 (20130101)
G06F 9/3877 (20130101)
G06F 16/2246 (20190101)
G06F 16/2255 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193291 Blake et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Robert C. Blake (Mountain House, California);  Thomas J. O'Hara (Alameda, California);  Mikel L. Landajuela (Dublin, California);  Rushil Anirudh (Dublin, California)
ABSTRACT A computer-based system and process are disclosed for reconstructing the internal electrical behavior of a patient's heart based partly or wholly on the patient's electrocardiogram (ECG). The output of the process may include, for example, a cardiac activation map, and/or a representation of transmembrane potentials over time. The process advantageously does not require any medical imaging of the patient, and does not require any special medical equipment. For example, the patient's activation map and transmembrane potentials may be reconstructed based solely on a preexisting or newly-obtained 12-lead cardiac ECG of the patient. The process makes use of a machine learning model, such as a neural network based model, trained with actual and/or simulated ECGs and intracardiac electrical data (typically transmembrane potentials) of many thousands of patients. Because an insufficient quantity of such data exists for actual patients, model training may be performed using ECGs and intracardiac electrical data obtained through computer simulations.
FILED Tuesday, November 24, 2020
APPL NO 17/103624
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/04 (20130101)
G06N 3/08 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/30 (20180101) Original (OR) Class
G16H 50/20 (20180101)
G16H 50/50 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193398 RAMAN et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Maxwell Technologies, Inc. (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) Santhanam RAMAN (San Diego, California);  James BORKENHAGEN (Spring Valley, California);  Xiaomei XI (Carlsbad, California);  Xiang-Rong YE (San Diego, California)
ABSTRACT An energy storage device can include a cathode, an anode, and a separator between the cathode and the anode, where the anode and/or electrode includes an electrode film having a super-fibrillized binder material and carbon. The electrode film can have a reduced quantity of the binder material while maintaining desired mechanical and/or electrical properties. A process for fabricating the electrode film may include a fibrillization process using reduced speed and/or increased process pressure such that fibrillization of the binder material can be increased. The electrode film may include an electrical conductivity promoting additive to facilitate decreased equivalent series resistance performance. Increasing fibrillization of the binder material may facilitate formation of thinner electrode films, such as dry electrode films.
FILED Thursday, February 11, 2021
APPL NO 17/173748
CURRENT CPC
Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 11/06 (20130101)
H01G 11/28 (20130101)
H01G 11/38 (20130101)
H01G 11/42 (20130101) Original (OR) Class
H01G 11/50 (20130101)
H01G 11/52 (20130101)
H01G 11/86 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/043 (20130101)
H01M 4/133 (20130101)
H01M 4/0416 (20130101)
H01M 4/587 (20130101)
H01M 4/621 (20130101)
H01M 4/625 (20130101)
H01M 10/0525 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 60/13 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193936 Li
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Jian Li (Tempe, Arizona)
ASSIGNEE(S) Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S) Jian Li (Tempe, Arizona)
ABSTRACT An organic light emitting diode having a substrate, a first electrode, a hole transporting layer proximate the first electrode, a second electrode, an electron transporting layer proximate the second electrode, and an emissive layer between the hole transporting layer and the electron transporting layer. The emissive layer includes a square planar tetradentate platinum or palladium complex, and excimers formed by two or more of the complexes are aligned such that emitting dipoles of the excimers are substantially parallel to a surface of the substrate.
FILED Wednesday, October 17, 2018
APPL NO 16/756219
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 15/006 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/02 (20130101)
C09K 11/06 (20130101)
C09K 2211/185 (20130101)
C09K 2211/1007 (20130101)
C09K 2211/1014 (20130101)
C09K 2211/1022 (20130101)
C09K 2211/1029 (20130101)
C09K 2211/1044 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/0084 (20130101) Original (OR) Class
H01L 51/5056 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194003 HERSAM et al.
FUNDED BY
Department of Energy (DOE)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Mark C. HERSAM (Wilmette, Illinois);  David LAM (Chicago, Illinois);  Kan-Sheng CHEN (Chicago, Illinois);  Joohoon KANG (Evanston, Illinois)
ABSTRACT Anhydrous liquid-phase exfoliation of germanium sulfide to provide few-layer germanium sulfide, as can be incorporated into electronic devices such as but not limited to batteries and cells comprising such materials.
FILED Wednesday, October 17, 2018
APPL NO 16/755680
CURRENT CPC
Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 17/00 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/5815 (20130101) Original (OR) Class
H01M 10/0525 (20130101)
H01M 2004/027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194004 ABRUÑA et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York);  WUHAN UNIVERSITY (Wuhan, China PRC)
ASSIGNEE(S) CORNELL UNIVERSITY (Ithaca, New York);  WUHAN UNIVERSITY (Wuhan, China PRC)
INVENTOR(S) Héctor D. ABRUÑA (Ithaca, New York);  Yao YANG (Ithaca, New York);  Fu-Sheng KE (Wuhan, China PRC);  Xiao-Chen LIU (Wuhan, China PRC)
ABSTRACT A titanium disulfide-sulfur (TiS2—S) composite particle contains a titanium disulfide (TiS2) substrate having solid elemental sulfur (S) disposed directly on a surface of the TiS2. The TiS2 substrate has a layered crystalline hexagonal structure of space group P-3 ml and includes at least 100 distinct layers. The TiS2 and S are present in the composite in a weight ratio (TiS2:S) of 20:80 to 50:50. Cathodes and batteries containing the composite particle, as well as related methods, are also disclosed.
FILED Thursday, December 20, 2018
APPL NO 16/771776
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/366 (20130101)
H01M 4/0404 (20130101)
H01M 4/622 (20130101)
H01M 4/625 (20130101)
H01M 4/5815 (20130101) Original (OR) Class
H01M 10/0525 (20130101)
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194031 Yang
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Jenny Y. Yang (Irvine, California)
ABSTRACT Redox flow battery systems utilizing the reversible interconversion between carbon dioxide, (or bicarbonate or carbonate) and formate/formic acid. The battery system comprises an electrocatalyst that converts carbon dioxide, bicarbonate, or carbonate into formate to store electron equivalents, and oxidizes formate to release stored electrons and discharge. A non-limiting example of an electrocatalyst that can be used for reversible interconversion of carbon dioxide and formate is Pt(depe)2.
FILED Thursday, December 17, 2020
APPL NO 17/125506
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/925 (20130101)
H01M 4/5825 (20130101)
H01M 8/188 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194042 Wolverton et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
APPLICANT(S) Northwestern University (Evanston, Illinois);  ARGONNE NATIONAL LABORATORY (Avenue, Illinois)
ASSIGNEE(S)
INVENTOR(S) Christopher M. Wolverton (Wilmette, Illinois);  Zhenpeng Yao (Skokie, Illinois);  Chun Zhan (Chicago, Illinois);  Jun Lu (Chicago, Illinois);  Khalil Amine (Chicago, Illinois)
ABSTRACT Cathode materials for lithium ion batteries, lithium ion batteries incorporating the cathode materials, and methods of operating the lithium ionbatteries are provided. The materials, which are composed of lithium iron oxides, are able to undergo reversible anionic and cationic redox reactions with no O2(g) generation.
FILED Thursday, December 06, 2018
APPL NO 16/769340
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/523 (20130101)
H01M 10/44 (20130101)
H01M 10/0525 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194059 ZHANG et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Zhengcheng ZHANG (Naperville, Illinois);  Qian LIU (Darien, Illinois)
ABSTRACT The ionic liquids disclosed herein are salts comprising a nitrogen or phosphorus such as a quaternary ammonium ion, a quaternary phosphonium ion, or an N-alkylated nitrogen heterocycle, and which include at least one functional substituent, e.g., a fluoro, cyano, carbonate ester, an alkenyl group, or an alkynyl group bonded to a carbon atom the cation. In a preferred embodiment, the cation is represented by the structure of Formula (I) as described herein.
FILED Friday, December 20, 2019
APPL NO 16/722413
CURRENT CPC
Heterocyclic Compounds
C07D 207/06 (20130101)
C07D 207/10 (20130101)
C07D 211/14 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/0525 (20130101)
H01M 10/0569 (20130101) Original (OR) Class
H01M 2300/0028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194415 Basel et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency Energy (ARPAE)
APPLICANT(S) SUNFOLDING, INC. (San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Louis Hong Basel (Berkeley, California);  Joshua Earle Erickson (Oakland, California);  Dan Goldwater (Amherst, Massachusetts);  Jeffrey Charles Lamb (San Francisco, California);  Leila Madrone (San Francisco, California);  Vincent Domenic Romanin (San Francisco, California);  Matthew N Schneider (Sierra Madre, California)
ABSTRACT A fluidic actuation system for controlling rotation of one or more panels, having a first valve circuit configured to be fluidically coupled to a first vessel and a fluid source, having a first and second valve; and a second valve circuit configured to be fluidically coupled to a second vessel and the fluid source, having a third and fourth valve. The first valve is configured to control a supply of fluid from the fluid source to the first vessel; the second valve is configured to release fluid from the first vessel; the third valve is configured to control a supply of the fluid from the fluid source to the second vessel; and the fourth valve is configured to release the fluid from the second vessel. Introduction or release of fluid from one or both the first and second vessels is configured to cause rotation of the one or more panels.
FILED Wednesday, February 17, 2021
APPL NO 17/178152
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/142 (20130101)

Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for
F15B 15/10 (20130101)

Solar Heat Collectors; Solar Heat Systems
F24S 30/425 (20180501)
F24S 50/20 (20180501)
F24S 2030/12 (20180501)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/042 (20130101)

Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules
H02S 20/10 (20141201)
H02S 20/32 (20141201) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194513 Deng et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
Pacific Northwest National Laboratory (PNNL)
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Z. Daniel Deng (Richland, Washington);  Jun Lu (Richland, Washington);  Huidong Li (Richland, Washington);  Chuan Tian (Richland, Washington);  Mitchell J. Myjak (Richland, Washington);  Brian J. Bellgraph (Richland, Washington);  Sam Cartmell (Richland, Washington);  Jie Xiao (Richland, Washington)
ABSTRACT Methods for attaching a radio frequency (RF) transmitter to an animal are provided. The methods can include providing an RF transmitter and providing an injection device having a needle of gauge of 9 or smaller; providing the RF transmitter into the injection device; and providing the RF transmitter through the 9 gauge or smaller needle and into the animal.
FILED Tuesday, February 09, 2021
APPL NO 17/172066
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 11/006 (20130101)
A01K 11/008 (20130101)
A01K 61/90 (20170101)
A01K 99/00 (20130101)

Diagnosis; Surgery; Identification
A61B 5/6861 (20130101)

Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 1/02 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 19/0723 (20130101)
G06K 19/07762 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/382 (20130101)
H01M 4/5835 (20130101)

Transmission
H04B 1/034 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194850 Johnson et al.
FUNDED BY
Department of Energy (DOE)
Battelle Energy Alliance, LLC (BEA)
APPLICANT(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)
INVENTOR(S) Briam Johnson (Idaho Falls, Idaho);  Michael V. McCarty (Idaho Falls, Idaho);  Rishi R. Chatterjee (Ammon, Idaho);  Kristopher Watts (Idaho Falls, Idaho)
ABSTRACT A method of monitoring and controlling network traffic within an industrial control system including receiving one or more data packets at a smart network switching system operating software-defined networking, analyzing the one or more data packets at a protocol level within a control plane of the software-defined networking, based on the analysis, determining whether the one or more data packets are authorized data packets, and forwarding a data packet of the one or more data packets to a destination device within a data plane of the software-defined networking upon determining that the data packet is an authorized data packet. The method further includes providing information related to the analysis of the one or more data packets to an out-of-band monitoring and control system for display to a user, and receiving a response communication from the out-of-band monitoring and control system indicating whether the one or more data packets are authorized data packets.
FILED Wednesday, June 12, 2019
APPL NO 17/253724
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 43/18 (20130101)
H04L 63/0236 (20130101) Original (OR) Class
H04L 63/1408 (20130101)
H04L 67/36 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194955 Cintuglu et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) ABB Schweiz AG (Baden, Switzerland)
ASSIGNEE(S)
INVENTOR(S) Mehmet H. Cintuglu (Raleigh, North Carolina);  Dmitry Ishchenko (Cary, North Carolina)
ABSTRACT Systems, methods, techniques and apparatuses of asynchronous communication is distributed systems are disclosed. One exemplary embodiment is a method determining, with a plurality of agent nodes structured to communicate asynchronously in a distributed system, a first set of iterations including an iteration determined by each of the plurality of agent nodes; determining, with a first agent node of the plurality of agent nodes, a local vector clock; receiving, with the first agent node, a first iteration of the first set of iterations and a remote vector clock determined based on the first iteration; updating, with the first agent node, the local vector clock based on the received remote vector clock; and determining a first iteration of a second set of iterations based on the first set of iterations after determining all iterations of the first set of iterations have been received based on the local vector clock.
FILED Wednesday, December 18, 2019
APPL NO 16/718685
CURRENT CPC
Electric Digital Data Processing
G06F 17/16 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 29/0854 (20130101)
H04L 67/1095 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194958 Jacob et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) Philip Jacob (Congers, New York);  Philip Neil Strenski (Yorktown Heights, New York);  Charles Johns (Austin, Texas)
ABSTRACT A system and method for federating a tuple storage database across multiple coordinated namespace (CNS) extended memory storage systems allowing the sharing of tuples and tuple data across independent systems. The method provides a federation service for multiple coordination namespace systems. The method retrieves a tuple from connected independent CNS systems wherein a local CNS Controller sends a read request to the local gatekeeper to retrieve a first tuple and creates a local pending remote record. The local gatekeeper at a requesting node sends a broadcast query to a plurality of remote gatekeepers for the tuple and Remote gatekeepers at remote nodes query in its local CNS for the tuple. The Local gatekeeper process at the requesting node receives results from a plurality of remote gatekeepers for the said tuple and selects one remote gatekeeper to receive the requested tuple and broadcasts a read for tuple data with selected gatekeeper.
FILED Wednesday, December 18, 2019
APPL NO 16/719440
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 12/18 (20130101)
H04L 67/1097 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210195086 Baba et al.
FUNDED BY
Department of Energy (DOE)
Pacific Northwest National Laboratory (PNNL)
UT-Battelle, LLC (UT-BATTELLE)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Justin S. Baba (Knoxville, Tennessee);  Philip R. Bingham (Knoxville, Tennessee);  David S. Bolme (Knoxville, Tennessee);  Matthew R. Eicholtz (Lakeland, Florida);  Regina Kay Ferrell (Knoxville, Tennessee);  Christi R. Johnson (Kingston, Tennessee);  Hector J. Santos-Villalobos (Knoxville, Tennessee)
ABSTRACT Methods and apparatus are disclosed for producing high quality images in uncontrolled or impaired environments. In some examples of the disclosed technology, groups of cameras for high dynamic range (HDR), polarization diversity, and optional other diversity modes are arranged to concurrently image a common scene. For example, in a vehicle checkpoint application, HDR provides discernment of dark objects inside a vehicle, while polarization diversity aids in rejecting glare. Spectral diversity, infrared imaging, and active illumination can be applied for better imaging through a windshield. Preprocessed single-camera images are registered and fused. Faces or other features of interest can be detected in the fused image and identified in a library. Impairments can include weather, insufficient or interfering lighting, shadows, reflections, window glass, occlusions, or moving objects.
FILED Monday, August 10, 2020
APPL NO 16/989222
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/209 (20130101)
G06K 9/00255 (20130101)
G06K 9/00785 (20130101)
G06K 9/00832 (20130101)

Image Data Processing or Generation, in General
G06T 5/002 (20130101)
G06T 5/007 (20130101)
G06T 5/008 (20130101)
G06T 5/50 (20130101)
G06T 2207/10028 (20130101)
G06T 2207/10048 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/20208 (20130101)
G06T 2207/20221 (20130101)

Pictorial Communication, e.g Television
H04N 5/33 (20130101)
H04N 5/247 (20130101)
H04N 5/2256 (20130101)
H04N 5/2258 (20130101)
H04N 5/2355 (20130101) Original (OR) Class
H04N 13/327 (20180501)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20210186010 Bassler et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S) The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S) Bonnie L. Bassler (Princeton, None);  Howard A. Stone (Princeton, None);  Min Young Kim (Seoul, South Korea);  Thomas William Muir (Princeton, New Jersey);  Aishan Zhao (Princeton, New Jersey)
ABSTRACT The invention relates to compositions comprising Quorum-Sensing (QS) modulating molecules attached to a surface via a linker. This QS modulator attached surface can then be used to modulate QS, biofilm production, biofilm streamer production and/or virulence factor production. The length of the linker that attaches the QS modulating molecule to the surface as well as the surface coverage density impact QS modulation on surfaces. These QS modulator attached surfaces can be used to treat areas known to contain human pathogens notorious for causing hospital-acquired infections as well as fatal infections that occur outside of health care settings. Other surfaces that can be coated according to embodiments of the invention include abiotic materials, such as intravenous catheters, implants, medical devices, and cooling towers. Preferred microorganisms that can be treated with the compositions of the invention include, but are not limited to S. aureus and/or P. aeruginosa. The QS modulator attached surface also demonstrates exceptional stability.
FILED Saturday, October 17, 2020
APPL NO 17/073326
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 25/08 (20130101)
A01N 25/10 (20130101) Original (OR) Class
A01N 35/04 (20130101)
A01N 43/16 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/18 (20130101)
C12Q 1/025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186426 Raju et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Science Foundation (NSF)
APPLICANT(S) University of Washington (Seattle, Washington);  Seattle Children's Hospital (DBA Seattle Children's Research Institute) (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington);  Seattle Children's Hospital (DBA Seattle Children's Research Institute) (Seattle, Washington)
INVENTOR(S) Sharat Raju (Seattle, Washington);  Shyamnath Gollakota (Seattle, Washington);  Justin Chan (Seattle, Washington);  Randall Bly (Seattle, Washington);  Rajalakshmi Nandakumar (Seattle, Washington)
ABSTRACT Examples of systems and methods described herein may estimate a state of the ear canal of a patient utilizing a smart phone by characterizing acoustic waveforms reflected off the patient's eardrum. Examples may include an acoustic focusing apparatus that may be connected to a smart phone to provide acoustic signals to and receive reflected signals from an ear canal.
FILED Friday, September 06, 2019
APPL NO 17/274137
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/742 (20130101)
A61B 5/6817 (20130101) Original (OR) Class
A61B 5/6898 (20130101)
A61B 5/7264 (20130101)
A61B 2560/0223 (20130101)
A61B 2562/12 (20130101)

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding
G10L 25/51 (20130101)

Telephonic Communication
H04M 1/035 (20130101)
H04M 1/2155 (20130101)

Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 1/08 (20130101)
H04R 1/025 (20130101)
H04R 1/345 (20130101)
H04R 2499/11 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186794 Seim et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Caitlyn Seim (Atlanta, Georgia);  Thad Eugene Starner (Atlanta, Georgia)
ABSTRACT Systems, devices, and methods disclosed herein can generally include passive tactile stimulation (“PTS”) for rehabilitation of neurological conditions, conditions resulting from stroke, conditions resulting from brain damage, tremors resulting from Parkinson's disease, cardiovascular disorder, spatial neglect, sensitivity loss, and/or muscle spasticity. Devices can be worn or applied during daily life and can be effective treatment for aforementioned conditions without a patent engaging in exercises, forced muscle contraction due to electrostimulation or repeated muscle vibration, or even focusing on the stimulation treatment.
FILED Wednesday, September 26, 2018
APPL NO 16/650154
CURRENT CPC
Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body
A61H 1/0274 (20130101) Original (OR) Class
A61H 23/0254 (20130101)
A61H 2201/0157 (20130101)
A61H 2201/165 (20130101)
A61H 2205/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186865 GU et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Zhen GU (Los Angeles, California);  Jinqiang WANG (Raleigh, North Carolina)
ABSTRACT Disclosed are compositions and methods for microneedle patches comprising diblock copolymer micelles designed for pH cascade and H2O2 triggered insulin delivery.
FILED Wednesday, October 10, 2018
APPL NO 16/755191
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0021 (20130101) Original (OR) Class
A61K 9/1075 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187010 Won et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) You-Yeon Won (West Lafayette, Indiana);  Hyun Chang Kim (Wilmington, Delaware)
ABSTRACT Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.
FILED Monday, November 30, 2020
APPL NO 17/107295
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/08 (20130101)
A61K 9/0019 (20130101)
A61K 9/0082 (20130101)
A61K 9/107 (20130101)
A61K 9/1075 (20130101)
A61K 31/765 (20130101) Original (OR) Class
A61K 47/34 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 11/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187158 WAGNER et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania);  UNIVERSITY OF CINCINNATI (Cincinnati, Ohio)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania);  UNIVERSITY OF CINCINNATI (Cincinnati, Ohio)
INVENTOR(S) WILLIAM R. WAGNER (GIBSONIA, Pennsylvania);  SANG-HO YE (CHESWICK, Pennsylvania);  YINGQI CHEN (PITTSBURGH, Pennsylvania)
ABSTRACT The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.
FILED Wednesday, April 04, 2018
APPL NO 16/498035
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/34 (20130101)
A61L 27/44 (20130101)
A61L 27/047 (20130101) Original (OR) Class
A61L 27/56 (20130101)
A61L 27/58 (20130101)
A61L 27/3608 (20130101)
A61L 27/3687 (20130101)
A61L 27/3691 (20130101)
A61L 2400/12 (20130101)
A61L 2420/02 (20130101)
A61L 2430/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187166 Banquy et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) VALORISATION RECHERCHE, LIMITED PARTNERSHIP (Montreal, Canada);  VALORISATION HSJ, LIMITED PARTNERSHIP (Montreal, Canada);  CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Xavier Banquy (Saint-Laurent, Canada);  Jimmy Faivre (Villeurbanne, France);  Buddha Ratna Shrestha (Montreal, Canada);  Krzysztof Matyjaszewski (Pittsburgh, Pennsylvania);  Joanna Burdynska (Berkeley, California);  Florina Moldovan (Montreal, Canada)
ABSTRACT A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.
FILED Monday, March 01, 2021
APPL NO 17/189144
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/16 (20130101)
A61L 27/50 (20130101) Original (OR) Class
A61L 31/10 (20130101)
A61L 31/14 (20130101)
A61L 2400/06 (20130101)
A61L 2400/10 (20130101)

Polysaccharides; Derivatives Thereof
C08B 37/0072 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 265/06 (20130101)
C08F 2438/01 (20130101)

Compositions of Macromolecular Compounds
C08L 5/08 (20130101)
C08L 51/003 (20130101)

Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition
C10M 107/44 (20130101)
C10M 107/48 (20130101)
C10M 173/02 (20130101)

Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions
C10N 2040/50 (20200501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187646 Byers et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Science Foundation (NSF)
APPLICANT(S) HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
ASSIGNEE(S) HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri)
INVENTOR(S) Kyle J. Byers (Kansas City, Missouri);  Daniel Scott Krueger (Liberty, Missouri);  Michael Walsh (Overland Park, Kansas);  William Price (Easton, Kansas)
ABSTRACT A method of manufacturing a compound object, such as an antenna, is disclosed. The method includes creating, via additive manufacturing, a first component formed at least in part of an oxidizing metal; applying, via vapor deposition, a solderable coating to at least a portion of the first component; and soldering at least a portion of the first component to a second component by applying a solder to the solderable coating of the first component. The oxidizing metal may be a titanium allow, such as Ti-6Al-4V. The solderable coating may include copper and/or tin-lead.
FILED Thursday, December 19, 2019
APPL NO 16/720445
CURRENT CPC
Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam
B23K 1/0008 (20130101)
B23K 1/20 (20130101) Original (OR) Class
B23K 2103/14 (20180801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 70/00 (20141201)

Alloys
C22C 14/00 (20130101)

Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188101 Abu Qahouq et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama);  JAQ Energy LLC (Tuscaloosa, Alabama)
ASSIGNEE(S)
INVENTOR(S) Jaber A. Abu Qahouq (Tuscaloosa, Alabama);  Amer Abu Qahouq (Tuscaloosa, Alabama)
ABSTRACT The exemplified systems and methods provide fixed and exchangeable energy storage and delivery system in an electrified vehicle architecture with multi-mode controls. The exchangeable energy storage are configured to be optional and ultra-portable. The integration of fixed and exchangeable energy storage provides a vehicle configuration that is further optimized for size, weight, and convenience.
FILED Tuesday, October 20, 2020
APPL NO 17/075077
CURRENT CPC
Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles
B60K 1/04 (20130101)
B60K 2001/0438 (20130101)
B60K 2001/0455 (20130101)

Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles
B60L 50/64 (20190201) Original (OR) Class
B60L 53/16 (20190201)
B60L 53/53 (20190201)
B60L 53/57 (20190201)
B60L 53/66 (20190201)
B60L 53/80 (20190201)
B60L 58/12 (20190201)
B60L 2240/425 (20130101)
B60L 2240/427 (20130101)
B60L 2240/429 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 2/1083 (20130101)
H01M 2220/20 (20130101)

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 7/00041 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188741 Marks et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Tobin Jay Marks (Evanston, Illinois);  Tracy L. Lohr (Houston, Texas);  Shanfu Liu (Chicago, Illinois);  Allison Marie Arinaga (Bethesda, Maryland)
ABSTRACT The present disclosure provides a method for the oxidative dehydrogenation of an alkane, e.g., ethane, propane, etc. In embodiments, a method for oxidative dehydrogenation of an alkane comprises exposing a gas comprising an alkane having 2 or more carbons to elemental sulfur vapor at an elevated reaction temperature and for a period of time to convert the alkane to one or more products via oxidative dehydrogenation, the one or more products comprising a primary alkene.
FILED Thursday, February 11, 2021
APPL NO 17/173663
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 21/04 (20130101)
B01J 23/22 (20130101)
B01J 27/04 (20130101)

Acyclic or Carbocyclic Compounds
C07C 5/46 (20130101) Original (OR) Class
C07C 2521/04 (20130101)
C07C 2523/22 (20130101)
C07C 2527/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189238 Kavazanjian et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Edward Kavazanjian (Tempe, Arizona);  Nasser Hamdan (Scottsdale, Arizona);  Hamed Khodadadi Tirkolaei (Tempe, Arizona);  Abdullah Almajed (Tempe, Arizona)
ABSTRACT The present disclosure provides a method of biocementation comprising contacting a granular, cohesionless soil with a solution, wherein the solution comprises urea, urease, a source of calcium ions, and a source of non-urease proteins, wherein the urea, urease, source of calcium ions, and source of non-urease proteins are provided in effective amounts suitable to cause crystallization of calcium carbonate.
FILED Thursday, March 04, 2021
APPL NO 17/192337
CURRENT CPC
Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 24/14 (20130101)
C04B 28/003 (20130101)
C04B 2103/0001 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 17/44 (20130101) Original (OR) Class

Foundations; Excavations; Embankments; Underground or Underwater Structures
E02D 3/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189359 Zhan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)
INVENTOR(S) Chang-Guo Zhan (Lexington, Kentucky);  Fang Zheng (Lexington, Kentucky);  Xiabin Chen (Lexington, Kentucky)
ABSTRACT The presently-disclosed subject matter describes fusion proteins comprising butyrylcholinesterase (BChE) having an improved production yield and biological half-life and nucleotides encoding the same.
FILED Monday, December 21, 2020
APPL NO 17/129736
CURRENT CPC
Peptides
C07K 2319/30 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/18 (20130101) Original (OR) Class

Enzymes
C12Y 301/01008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189445 Smolke et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Science Foundation (NSF)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Christina D. Smolke (Menlo Park, California);  Catherine Thodey (Mountain View, California);  Isis Trenchard (Redwood City, California);  Stephanie Galanie (Palo Alto, California)
ABSTRACT Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention.
FILED Tuesday, October 13, 2020
APPL NO 17/069066
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0073 (20130101)
C12N 9/1007 (20130101)
C12N 15/52 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 17/18 (20130101)
C12P 17/182 (20130101) Original (OR) Class

Enzymes
C12Y 121/03003 (20130101)
C12Y 201/0114 (20130101)
C12Y 201/01116 (20130101)
C12Y 201/01128 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189463 Seelig et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Georg Seelig (Seattle, Washington);  Richard Muscat (Seattle, Washington);  Alexander B. Rosenberg (Seattle, Washington)
ABSTRACT Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
FILED Thursday, February 25, 2021
APPL NO 17/249257
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101) Original (OR) Class
C12Q 1/6855 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190593 Yao et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S) Yu Yao (Chandler, Arizona);  Chao Wang (Chandler, Arizona);  Chu Wang (Mesa, Arizona);  Jing Bai (Tempe, Arizona);  Ali Basiri (Tempe, Arizona);  Xiahui Chen (Mesa, Arizona)
ABSTRACT A polarization sensor is described. It includes a quarter-wave plate to convert circularly polarized light into linearly polarized light. The quarter-wave plate is realized as a metasurface. The sensor also includes a linear polarizer to analyze the light generated by the quarter-wave plate, and a photodetector to receive the analyzed light. The sensor may be combined with other linear polarization sensors to form a sensor capable of complete measurement of the polarization state of incident light. An array of these sensors can be integrated directly onto image sensors to form a polarimetric imager.
FILED Friday, December 21, 2018
APPL NO 16/956988
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 4/04 (20130101) Original (OR) Class

Optical Elements, Systems, or Apparatus
G02B 5/3025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190648 Dark
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Science Foundation (NSF)
APPLICANT(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S) Phillip Ryan Dark (Kansas City, Kansas)
ABSTRACT An apparatus for simulating an oscillating flight path is provided. The apparatus comprises a slide extending along a first axis; a support structure slidably coupled to the slide; and a table connected to the support structure. The support structure is operable to move along the slide. The table is coupled to the support structure and operable to rotate about a second axis orthogonal to the first axis. The table comprises a surface that is parallel to the second axis and that is operable to rotate about a third axis orthogonal to the second axis.
FILED Wednesday, December 16, 2020
APPL NO 17/123290
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/28 (20130101) Original (OR) Class
G01N 2001/002 (20130101)
G01N 2001/2893 (20130101)

Electric Digital Data Processing
G06F 16/901 (20190101)

Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils
H02P 29/40 (20160201)
H02P 29/60 (20160201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190772 Mendes et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky)
ASSIGNEE(S)
INVENTOR(S) Sergio Brito Mendes (Louisville, Kentucky);  Martin O'Toole (Louisville, Kentucky)
ABSTRACT Immunosensors according to present embodiments combine a sandwich bioassay with an electrochemical surface plasmon resonance device for electrochemical detection of analytes from a sample, whereby a coated substrate for receiving an electroactive probe may be located in a flow cell, and the coated substrate comprises a first layer which is a silver (Ag) layer and a second layer which is a gold (Au) layer arranged so that the gold layer isolates the silver layer from an operating environment.
FILED Friday, February 12, 2021
APPL NO 17/174658
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/648 (20130101)
G01N 21/1717 (20130101)
G01N 27/305 (20130101)
G01N 27/3277 (20130101)
G01N 33/5438 (20130101) Original (OR) Class
G01N 33/56983 (20130101)
G01N 2021/1721 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191036 LIPSON et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Michal LIPSON (New York, New York);  Mohammad Amin TADAYON (Bronx, New York)
ABSTRACT An optical apparatus comprises a waveguide and a plurality of optical components disposed in the waveguide. The optical components disposed in the waveguide direct light rays indicative of an image through at least a portion of the waveguide. The optical components can be configured to preserve a wave front of the represented image. In various embodiments, the optical elements are at least one of lenses, mirrors, and filters. Various methods of making and using the optical apparatus are disclosed herein.
FILED Tuesday, May 14, 2019
APPL NO 17/055465
CURRENT CPC
Producing Particular Articles From Plastics or From Substances in a Plastic State
B29D 11/00663 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 80/00 (20141201)

Optical Elements, Systems, or Apparatus
G02B 6/02052 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191046 SEOK et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Tae Joon SEOK (Berkeley, California);  Ming Chiang A WU (Moraga, California)
ABSTRACT A large-scale single-photonics-based optical switching system that occupies an area larger than the maximum area of a standard step-and-repeat lithography reticle is disclosed. The system includes a plurality of identical switch blocks, each of is formed in a different reticle field that no larger than the maximum reticle size. Bus waveguides of laterally adjacent switch blocks are stitched together at lateral interfaces that include a second arrangement of waveguide ports that is common to all lateral interfaces. Bus waveguides of vertically adjacent switch blocks are stitched together at vertical interfaces that include a first arrangement of waveguide ports that is common to all vertical interfaces. In some embodiments, the lateral and vertical interfaces include waveguide ports having waveguide coupling regions that are configured to mitigate optical loss due to stitching error.
FILED Thursday, November 29, 2018
APPL NO 16/768233
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/3508 (20130101)
G02B 6/3546 (20130101) Original (OR) Class
G02B 6/12007 (20130101)
G02B 6/29344 (20130101)
G02B 2006/12145 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191095 Howard et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) UNIVERSITY OF NOTRE DAME (South Bend, Indiana)
ASSIGNEE(S)
INVENTOR(S) Scott Howard (Notre Dame, Indiana);  Genevieve Vigil (South Bend, Indiana);  Yide ZHANG (South Bend, Indiana)
ABSTRACT One aspect of the present disclosure relates to systems and methods that can be used for super-sensitivity multiphoton frequency-domain fluorescence lifetime imaging microscopy (MPM-FD-FLIM). One or more laser light sources can deliver excitation light with an intensity modulated by a periodic function to a sample, which includes a fluorophore concentration. A receiver can receive a fluorescence signal emitted from the fluorophore concentration over a time period. A computing device can transform the fluorescence signal to the frequency domain and measure a fluorescence lifetime associated with the sample in the frequency domain based on a DC component and at least one higher harmonic component generated by non-linear optical mixing of the modulated excitation light. Using the DC component and the at least one higher harmonic component can increase the sensitivity of an image created by the MPM-FD-FLIM system.
FILED Friday, March 10, 2017
APPL NO 16/076172
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/06 (20130101) Original (OR) Class
G02B 21/16 (20130101)
G02B 21/365 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210191717 Mayer et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Mikaël Mayer (Chicago, Illinois);  Ravi Chugh (Chicago, Illinois)
ABSTRACT A method of facilitating bidirectional programming of a user may include receiving an original program source code and evaluating the original program source code in the forward direction to generate a program output. The evaluation may occur in a programming environment. The program output may be displayed, and an indication of the user corresponding to modifying the program output may be received. The modified program output may be evaluated to generate an updated program source code, wherein the updated program source code, when evaluated, may generate the modified program output. The modified program output may be displayed in a display device of the user. A computing system including a bidirectional programming environment may also be included.
FILED Wednesday, January 27, 2021
APPL NO 17/160098
CURRENT CPC
Electric Digital Data Processing
G06F 8/34 (20130101)
G06F 8/71 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192113 NAM et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland);  IonQ, Inc. (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) Yunseong NAM (North Bethesda, Maryland);  Dmitri MASLOV (Falls Church, Virginia);  Andrew CHILDS (Bethesda, Maryland);  Neil Julien ROSS (Halifax, Canada);  Yuan SU (Hyattsville, Maryland)
ABSTRACT The disclosure describes the implementation of automated techniques for optimizing quantum circuits of the size and type expected in quantum computations that outperform classical computers. The disclosure shows how to handle continuous gate parameters and report a collection of fast algorithms capable of optimizing large-scale-scale quantum circuits. For the suite of benchmarks considered, the techniques described obtain substantial reductions in gate counts. In particular, the techniques in this disclosure provide better optimization in significantly less time than previous approaches, while making minimal structural changes so as to preserve the basic layout of the underlying quantum algorithms. The results provided by these techniques help bridge the gap between computations that can be run on existing quantum computing hardware and more advanced computations that are more challenging to implement in quantum computing hardware but are the ones that are expected to outperform what can be achieved with classical computers.
FILED Tuesday, February 02, 2021
APPL NO 17/165707
CURRENT CPC
Electric Digital Data Processing
G06F 30/39 (20200101)
G06F 30/327 (20200101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192132 Birnbaum et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) Narrative Science Inc. (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Lawrence A. Birnbaum (Evanston, Illinois);  Kristian J. Hammond (Chicago, Illinois);  Nicholas D. Allen (Chicago, Illinois);  John R. Templon (Chicago, Illinois)
ABSTRACT A system and method for automatically generating a narrative story receives data and information pertaining to a domain event. The received data and information and/or one or more derived features are then used to identify a plurality of angles for the narrative story. The plurality of angles is then filtered, for example through use of parameters that specify a focus for the narrative story, length of the narrative story, etc. Points associated with the filtered plurality of angles are then assembled and the narrative story is rendered using the filtered plurality of angles and the assembled points.
FILED Monday, March 08, 2021
APPL NO 17/195193
CURRENT CPC
Electric Digital Data Processing
G06F 16/22 (20190101)
G06F 16/2365 (20190101)
G06F 40/20 (20200101) Original (OR) Class
G06F 40/106 (20200101)
G06F 40/166 (20200101)
G06F 40/289 (20200101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192146 Lee et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Clinc, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Andrew Lee (Ann Arbor, Michigan);  Zhenguo Chen (Ann Arbor, Michigan);  Jonathan K. Kummerfeld (Ann Arbor, Michigan)
ABSTRACT A system and method for implementing slot-relation extraction for a task-oriented dialogue system that includes implementing dialogue intent classification machine learning models that predict a category of dialogue of a single utterance based on an input of utterance data relating to the single utterance, wherein the category of dialogue informs a selection of slot-filling machine learning models; implementing the slot-filling machine learning models that predict slot classification labels for each of a plurality of slots within the utterance based on the input of the utterance data; implementing a slot relation extraction machine learning model that predicts semantic relationship classifications between two or more distinct slots of tokens of the utterance; and generating a response to the single utterance or performing actions in response to the single utterance based on the semantic relationship classifications between the distinct pairings of the two or more distinct slots of the single utterance.
FILED Wednesday, February 10, 2021
APPL NO 17/172871
CURRENT CPC
Electric Digital Data Processing
G06F 40/35 (20200101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/049 (20130101)
G06N 20/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192352 Wang et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Yanzhi Wang (Newton Highlands, Massachusetts);  Xue Lin (Newton Highlands, Massachusetts)
ABSTRACT ADMM-NN is an algorithm-hardware co-optimization framework of DNNs using Alternating Direction Method of Multipliers (ADMM). The first part of ADMM-NN is a systematic, joint framework of DNN weight pruning and quantization using ADMM. The second part is a hardware-aware optimization to facilitate hardware-level implementations. ADMM-based weight pruning and quantization accounts for (i) computation reduction and energy efficiency improvement and (ii) performance overhead due to irregular sparsity. Experimental results demonstrate that by combining weight pruning and quantization, the proposed framework can achieve 1,910× and 231× reductions in the overall model size on the LeNet-5 and AlexNet models. Favorable results are also observed on VGGNet and ResNet models. Also, without any accuracy loss, 3.6× reduction in the amount of computation can be achieved, outperforming prior work.
FILED Monday, December 21, 2020
APPL NO 17/128763
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/063 (20130101)
G06N 3/082 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192762 Guan et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Junfeng Guan (Champaign, Illinois);  Seyedsohrab Madani (Champaign, Illinois);  Suraj S. Jog (Champaign, Illinois);  Haitham Al Hassanieh (Champaign, Illinois);  Saurabh Gupta (Champaign, Illinois)
ABSTRACT A method includes receiving data including a plurality of data items, each data item of the plurality of data items including a three-dimensional (3D) radar heat map of an object and a corresponding two-dimensional (2D) image of the object captured by a stereo camera, inputting the training dataset into a machine learning model including a neural network (NN) that generates, from the 3D radar heat map, a 2D depth map for the object and outputs a probability that the 2D depth map is the corresponding 2D image of the object, and training the machine learning model based on a training dataset to generate a trained machine learning model that iteratively learns to generate an updated 2D depth map that approximates the corresponding 2D image. The training dataset includes the plurality of data items, the 2D depth map and the probability.
FILED Thursday, December 17, 2020
APPL NO 17/124637
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00208 (20130101)

Image Data Processing or Generation, in General
G06T 7/593 (20170101) Original (OR) Class
G06T 15/04 (20130101)
G06T 15/06 (20130101)
G06T 2207/10028 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193127 Kang et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Clinc, Inc. (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Yiping Kang (Ann Arbor, Michigan);  Michael A. Laurenzano (Ann Arbor, Michigan);  Johann Hauswald (Ann Arbor, Michigan);  Lingjia Tang (Ann Arbor, Michigan);  Jason Mars (Ann Arbor, Michigan)
ABSTRACT Systems and methods for building a response for a machine learning-based dialogue agent includes implementing machine learning classifiers that predict slot segments of the utterance data based on an input of the utterance data; predict a slot classification label for each of the slot segments of the utterance data; computing a semantic vector value for each of the slot segments of the utterance data; assessing the semantic vector value of the slot segments of the utterance data against a multi-dimensional vector space of structured categories of dialogue, wherein the assessment includes: for each of a distinct structured categories of dialogue computing a similarity metric value; selecting one structured category of dialogue from the distinct structured categories of dialogue based on the computed similarity metric value for each of distinct structured categories; and producing a response to the utterance data.
FILED Tuesday, January 26, 2021
APPL NO 17/158052
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 5/04 (20130101)
G06N 20/00 (20190101)

Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding
G10L 15/04 (20130101)
G10L 15/22 (20130101)
G10L 15/1815 (20130101) Original (OR) Class
G10L 2015/223 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193447 JARROLD et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana)
ASSIGNEE(S)
INVENTOR(S) Martin F. JARROLD (Bloomington, Indiana);  Staci N. ANTHONY (Grandview, Ohio);  Benjamin E. DRAPER (Bloomington, Indiana)
ABSTRACT An interface transports ions from a first pressure environment to a lower pressure analysis instrument and may include a first region pumped to a second pressure less than the first pressure, a first ion funnel disposed in the first region, a first ion carpet in the first region opposite an ion outlet end of the first ion funnel, a second region pumped to a third pressure less than the second pressure and greater than the instrument pressure, a second ion funnel disposed in the second region and a second ion carpet in the second region opposite an ion outlet end of the second ion funnel. Ions from the environment pass sequentially through the first and second ion funnels and into the analysis instrument. Each of the first and second ion funnels define a tapered axial passageway therethrough each defining a respective virtual jet disrupter therein.
FILED Tuesday, June 04, 2019
APPL NO 17/058544
CURRENT CPC
Electric Discharge Tubes or Discharge Lamps
H01J 49/022 (20130101)
H01J 49/24 (20130101)
H01J 49/025 (20130101)
H01J 49/066 (20130101) Original (OR) Class
H01J 49/425 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193857 Gamelin et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Daniel R. Gamelin (Seattle, Washington);  Theodore Cohen (Seattle, Washington);  Daniel M. Kroupa (Seattle, Washington);  Matthew J. Crane (Seattle, Washington);  John Devin Mackenzie (Seattle, Washington);  Christine Keiko Luscombe (Seattle, Washington);  Tyler J. Milstein (Seattle, Washington)
ABSTRACT The present disclosure features a luminescent solar concentrator, including a layer including a quantum-cutting material; and a layer including a broadly light-absorbing material (that is also photoluminescent) optically coupled to and beneath the layer including the quantum-cutting material, relative to a light source.
FILED Wednesday, July 03, 2019
APPL NO 17/257846
CURRENT CPC
Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/621 (20130101)
C09K 11/7705 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/055 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210193880 ONG et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Shyue Ping ONG (La Jolla, California);  Jungmin HA (La Jolla, California);  Zhenbin WANG (La Jolla, California);  Joanna MCKITTRICK (La Jolla, California);  Won Bin IM (La Jolla, California);  Yoon Hwa KIM (La Jolla, California)
ABSTRACT A light emitting diode (LED) assembly includes an LED light source having a first light output with a characteristic spectrum and at least one phosphor through which the first light output passes. The phosphor includes the quaternary compound M-Li—Al—O, where M is Ba, Sr, or Ca, activated by Eu2+ or Ce3+.
FILED Monday, October 15, 2018
APPL NO 16/755533
CURRENT CPC
Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals
C01F 7/166 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/54 (20130101)
C01P 2002/72 (20130101)
C01P 2002/74 (20130101)
C01P 2002/77 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/7721 (20130101)
C09K 11/7734 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 33/502 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194003 HERSAM et al.
FUNDED BY
Department of Energy (DOE)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Mark C. HERSAM (Wilmette, Illinois);  David LAM (Chicago, Illinois);  Kan-Sheng CHEN (Chicago, Illinois);  Joohoon KANG (Evanston, Illinois)
ABSTRACT Anhydrous liquid-phase exfoliation of germanium sulfide to provide few-layer germanium sulfide, as can be incorporated into electronic devices such as but not limited to batteries and cells comprising such materials.
FILED Wednesday, October 17, 2018
APPL NO 16/755680
CURRENT CPC
Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 17/00 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/5815 (20130101) Original (OR) Class
H01M 10/0525 (20130101)
H01M 2004/027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194004 ABRUÑA et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York);  WUHAN UNIVERSITY (Wuhan, China PRC)
ASSIGNEE(S) CORNELL UNIVERSITY (Ithaca, New York);  WUHAN UNIVERSITY (Wuhan, China PRC)
INVENTOR(S) Héctor D. ABRUÑA (Ithaca, New York);  Yao YANG (Ithaca, New York);  Fu-Sheng KE (Wuhan, China PRC);  Xiao-Chen LIU (Wuhan, China PRC)
ABSTRACT A titanium disulfide-sulfur (TiS2—S) composite particle contains a titanium disulfide (TiS2) substrate having solid elemental sulfur (S) disposed directly on a surface of the TiS2. The TiS2 substrate has a layered crystalline hexagonal structure of space group P-3 ml and includes at least 100 distinct layers. The TiS2 and S are present in the composite in a weight ratio (TiS2:S) of 20:80 to 50:50. Cathodes and batteries containing the composite particle, as well as related methods, are also disclosed.
FILED Thursday, December 20, 2018
APPL NO 16/771776
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/366 (20130101)
H01M 4/0404 (20130101)
H01M 4/622 (20130101)
H01M 4/625 (20130101)
H01M 4/5815 (20130101) Original (OR) Class
H01M 10/0525 (20130101)
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194141 McKinstry et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Syght,Inc. (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Kevin D. McKinstry (Westminster, California);  Charles C. Partee (Golden, Colorado)
ABSTRACT An apparatus includes a horn having a horn body including at least one horn sidewall defining a first opening that tapers down to a second opening in a direction of elongation and a port that is tubular and dimensionally uniform transverse to the direction of elongation and extends in the direction of elongation from a first port end that is in communication with the second opening to a second port end that defines an external opening. A dielectric rod includes a rod length extending between a first rod end and a second rod end with the first rod end extending through the external opening of the second port end and into the port cavity such that the first rod end is in a spaced apart relationship from the port sidewall along the light path.
FILED Thursday, February 11, 2021
APPL NO 17/174071
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 5/0803 (20130101)

Antennas, i.e Radio Aerials
H01Q 13/02 (20130101) Original (OR) Class

Transmission
H04B 10/90 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194565 Paramesh et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Jeyanandh Paramesh (Pittsburgh, Pennsylvania);  Susnata Mondal (Pittsburgh, Pennsylvania);  L. Richard Carley (Pittsburgh, Pennsylvania)
ABSTRACT Disclosed herein is an innovative multi-layer hybrid/digital MIMO architecture that comprises single-stream or fully-connected (FC) multi-stream beamforming tiles (with RF complex-weights) in the first layer, followed by a fully connected (analog/digital) baseband layer. This architecture overcomes the complexity versus spectral-efficiency tradeoffs of existing hybrid MIMO architectures and enables MIMO stream/user scalability, superior energy-efficiency, and spatial-processing flexibility.
FILED Monday, February 01, 2021
APPL NO 17/164079
CURRENT CPC
Transmission
H04B 1/16 (20130101)
H04B 1/0028 (20130101)
H04B 1/0078 (20130101)
H04B 7/088 (20130101) Original (OR) Class
H04B 7/0413 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20210185990 Fahrenkrug et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Recombinetics, Inc. (Eagan, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Scott C. Fahrenkrug (Minneapolis, Minnesota);  Daniel F. Carlson (Woodbury, Minnesota)
ABSTRACT Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature. One embodiment includes compositions and methods for making livestock with a polled allele, including migrating a polled allele into a bovine species without changing other genes or chromosomal portions.
FILED Thursday, December 10, 2020
APPL NO 17/118064
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0275 (20130101)
A01K 67/0276 (20130101) Original (OR) Class
A01K 2227/40 (20130101)
A01K 2227/101 (20130101)
A01K 2227/102 (20130101)
A01K 2227/103 (20130101)
A01K 2227/107 (20130101)
A01K 2227/108 (20130101)

Peptides
C07K 14/47 (20130101)
C07K 14/715 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101)
C12N 15/90 (20130101)
C12N 15/902 (20130101)
C12N 15/907 (20130101)
C12N 15/8509 (20130101)
C12N 15/8771 (20130101)
C12N 15/8778 (20130101)
C12N 2750/14143 (20130101)
C12N 2800/30 (20130101)
C12N 2800/90 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186019 Chauhan
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Kamlesh R. Chauhan (Laurel, Maryland)
ABSTRACT Disclosed are compositions for attracting insects (e.g., harmful or troublesome insects such as blood-sucking and biting insects, ticks and mites) to an object (e.g., insect trap) or area (e.g., field, orchard). Also disclosed are methods for attracting insects involving treating (or exposing) the object or area with a composition containing compounds described herein (e.g., a pro-fragrance compound selected from the group consisting of an acetal, a ketal, hemiacetal and mixtures thereof, wherein at least one of a parent aldehyde, ketone, or alcohol of the pro-fragrance acetal or ketal is a fragrance compound), and optionally a carrier or carrier material.
FILED Wednesday, February 17, 2021
APPL NO 17/177370
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 31/06 (20130101)
A01N 35/02 (20130101)
A01N 43/08 (20130101)
A01N 43/28 (20130101) Original (OR) Class
A01N 43/30 (20130101)

Acyclic or Carbocyclic Compounds
C07C 43/184 (20130101)
C07C 43/317 (20130101)
C07C 2601/08 (20170501)
C07C 2601/14 (20170501)

Heterocyclic Compounds
C07D 307/20 (20130101)
C07D 317/12 (20130101)
C07D 317/72 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210186031 CANO MOGROVEJO et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) University of Florida Research Foundation, Inc. (Gainesville, Florida);  The United States of America as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Liliana M. CANO MOGROVEJO (Fort Pierce, Florida);  Marco PITINO (Fort Pierce, Florida);  Lorenzo ROSSI (Fort Pierce, Florida);  Robert SHATTERS (Fort Pierce, Florida)
ABSTRACT Disclosed herein are compositions, methods, and kits for suppression in huanglongbing (HLB) in a subject having HLB (or otherwise for treatment of symptoms of HLB in a subject in need thereof. In embodiments, compositions and methods as described herein comprise compositions relating to oak leaf extract to applied to or around citrus plants having or suspected of having HLB.
FILED Friday, December 18, 2020
APPL NO 17/126757
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 65/28 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210187095 RIEDER et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
Department of Agriculture (USDA)
APPLICANT(S) LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (LIVERMORE, California);  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (WASHINGTON, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Aida E. RIEDER (Westbrook, Connecticut);  Teresa B. DE LOS SANTOS (Miller Place, New York);  Luis L. RODRIGUEZ (Clinton, Connecticut);  Devendra RAI (Old Saybrook, Connecticut);  Fayna C. DIAZ-SAN SEGUNDO (Ronkonkoma, New York);  Paul D. HOEPRICH (Pleasanton, California)
ABSTRACT Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.
FILED Tuesday, February 16, 2021
APPL NO 17/176989
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/135 (20130101) Original (OR) Class
A61K 2039/55566 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2770/32122 (20130101)
C12N 2770/32134 (20130101)
C12N 2770/32141 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/70 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/53 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210188939 Rowland et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Kansas State University Research Foundation (Manhattan, Kansas)
ASSIGNEE(S)
INVENTOR(S) Raymond R.R. Rowland (Manhattan, Kansas);  Ana Stoian (Manhattan, Kansas)
ABSTRACT The present disclosure provides compositions and methods for decreasing permissiveness to infection by PRRSV. The methods involve inserting peptides or oligopeptides into the CD163 SRCR domain 5 to disrupt the protein structure and thereby prevent PRRSV infection. The deletion of the exon 13 region of PSTII eliminates infection. The replacement of cysteine residues with alanines in SRCR5 as a means to disrupt disulfide bond formation. The final method is the deletion of, or amino acid substitution within the SRCR4-5 interdomain region.
FILED Tuesday, October 16, 2018
APPL NO 16/756756
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/027 (20130101)

Peptides
C07K 14/705 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189410 DENG et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Zhanao DENG (Wimauma, Florida);  Saroj PARAJULI (Wimauma, Florida)
ABSTRACT Disclosed herein our novel methods of increasing resistance of Citrus plants to diseases, in particular, citrus canker disease caused by Xanthomonas citri ssp. citri and Huanglongbing disease. Some embodiments relate to novel methods of altering gene sequence, structure and expression of certain disease susceptibility genes in the Citrus plant. Other embodiments relate to gene constructs equipped to be introduced into Citrus cells and direct modifications to target gene sequences.
FILED Friday, November 27, 2020
APPL NO 17/105928
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/8213 (20130101) Original (OR) Class
C12N 15/8281 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210189511 HYLDIG-NIELSEN et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) APPLIED BIOSYSTEMS, LLC (Carlsbad, California)
ASSIGNEE(S)
INVENTOR(S) Jens J. HYLDIG-NIELSEN (Hillerod, Denmark);  Henrik STENDER (Gentofte, Denmark);  Kenneth M. OLIVEIRA (Sudbury, Massachusetts);  Susan RIGBY (Acton, Massachusetts)
ABSTRACT This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of one or more species of Candida yeast. Non-limiting examples of probing nucleobase sequences that can be used for the probes of this invention can be selected from the group consisting of: AGA-GAG-CAG-CAT-GCA (Seq. Id. No. 1), AGA-GAG-CAA-CAT-GCA (Seq. Id. No. 2), ACA-GCA-GAA-GCC-GTG (Seq. Id. No. 3), CAT-AAA-TGG-CTA-CCA-GA (Seq. Id. No. 4), CAT-AAA-TGG-CTA-CCC-AG (Seq. Id. No. 5), ACT-TGG-AGT-CGA-TAG (Seq. Id. No. 6), CCA-ACG-CTT-ATA-CTC-GC (Seq. Id. No. 7), CCC-CTG-AAT-CGG-GAT (Seq. Id. No. 8), GAC-GCC-AAA-GAC-GCC (Seq. Id. No. 9), ATC-GTC-AGA-GGC-TAT-AA (Seq. Id. No. 10), TAG-CCA-GAA-GAA-AGG (Seq. Id. No. 11), CAT-AAA-TGG-CTA-GCC-AG (Seq. Id. No. 12), CTC-CGA-TGT-GAC-TGC-G (Seq. Id. No. 13), TCC-CAG-ACT-GCT-CGG (Seq. Id. No. 14), TCC-AAG-AGG-TCG-AGA (Seq. Id. No. 15), GCC-AAG-CCA-CAA-GGA (Seq. Id. No. 16), GCC-GCC-AAG-CCA-CA (Seq. Id. No. 17), GGA-CTT-GGG-GTT-AG (Seq. Id. No. 18), CCG-GGT-GCA-TTC-CA (Seq. Id. No. 19), ATG-TAG-AAC-GGA-ACT-A (Seq. Id. No. 20), GAT-TCT-CGG-CCC-CAT-G (Seq. Id. No. 21), CTG-GTT-CGC-CAA-AAA-G (Seq. Id. No. 22) and AGT-ACG-CAT-CAG-AAA (Seq. Id. No. 23).
FILED Wednesday, September 23, 2020
APPL NO 17/029575
CURRENT CPC
Peptides
C07K 14/003 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101)
C12Q 1/6895 (20130101) Original (OR) Class
C12Q 2525/107 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210190782 Talaat
FUNDED BY
Department of Agriculture (USDA)
Agricultural Research Service (ARS)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Adel M. Talaat (Madison, Wisconsin)
ABSTRACT Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.
FILED Monday, February 08, 2021
APPL NO 17/170856
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5695 (20130101) Original (OR) Class
G01N 33/56933 (20130101)
G01N 2333/30 (20130101)
G01N 2469/10 (20130101)
G01N 2469/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

United States Postal Service (USPS) 

US 20210191930 ZENG et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Hui ZENG (Fairfax, Virginia);  Douglas R. SHUMWAY (Gaithersburg, Maryland);  Paul A. GESKE (Raleigh, North Carolina);  Wilairat UDOMSAWAT (Fairfax, Virginia)
ABSTRACT A computer-implemented method includes receiving data records from a plurality of different data sources, in which the data records include information regarding elements or components in one or more systems; consolidating the data records; extracting information from the consolidated data records to identify a plurality of nodes and connections between the plurality of nodes in the one or more systems; storing information identifying the plurality of nodes and the connections; and visually presenting the plurality of nodes and the connections in a user interface.
FILED Tuesday, December 22, 2020
APPL NO 17/131080
CURRENT CPC
Electric Digital Data Processing
G06F 16/252 (20190101)
G06F 16/258 (20190101)
G06F 16/2428 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192373 LUCKAY et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Ryan LUCKAY (Reston, Virginia);  Robert E. DIXON, JR. (Haymarket, Virginia);  Heather KELLY (Alexandria, Virginia)
ABSTRACT A computer-implemented method includes monitoring analytics data for a delivery item; accessing a user profile for a user associated with the delivery item; detecting the occurrence of an event trigger based on the analytics data and the user profile; and executing a proactive mitigating action based on detecting the occurrence of the event trigger. Associated systems and computer program products are also described.
FILED Friday, December 18, 2020
APPL NO 17/127404
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 5/04 (20130101) Original (OR) Class
G06N 20/00 (20190101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/109 (20130101)
G06Q 10/0833 (20130101)
G06Q 10/0838 (20130101)
G06Q 10/06312 (20130101)
G06Q 10/08355 (20130101)
G06Q 30/016 (20130101)
G06Q 30/0201 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192443 Hess et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Juliaann Sanders Hess (Pembroke Pines, Florida);  Seth Lee Johnson (Memphis, Tennessee)
ABSTRACT A system and method for geo-certifying delivery of items is disclosed. In some embodiments, a system tracks the intended delivery addresses of items as well as the actual delivery points. The system then determines if it has geo-verified geo-coordinates for the intended delivery points. If so, the system geo-certifies a delivery if the actual delivery point is within a geofence surrounding the intended delivery address.
FILED Monday, December 21, 2020
APPL NO 17/128617
CURRENT CPC
Electric Digital Data Processing
G06F 16/24575 (20190101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/0833 (20130101) Original (OR) Class
G06Q 10/0838 (20130101)

Wireless Communication Networks
H04W 4/021 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192444 QUINN et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Steven R. QUINN (Arlington, Virginia);  Han T. DINH (Falls Church, Virginia);  Charles P. MCLELLAN (Fairfax, Virginia)
ABSTRACT A scanning device mounting apparatus includes a mounting component, which may be magnetic; a hose coupled to the mounting component at a first distal end of the hose; an adjusting component coupled to a second distal end of the hose; and a cradle coupled to the adjusting component. The cradle can hold a scanning device, and the scanning device mounting apparatus is configured to position the scanning device in a manner that allows the scanning device to scan the labels on items that are being moved under or near the scanning device, such as packages or other items that are being loaded onto a delivery vehicle.
FILED Tuesday, December 22, 2020
APPL NO 17/131112
CURRENT CPC
Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/087 (20130101)
G06Q 10/0833 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210192795 Simpson
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Ryan J. Simpson (Vienna, Virginia)
ABSTRACT This application relates to a system for compressing captured images. The system may include an image capturing device configured to continuously capture images, for example, of a location, or frame, or field of view, and convert the captured images respectively into a plurality of sets of digital data, each of the plurality of sets of digital data including at least two consecutive rows of digital data. The system may also include a processor circuit configured to combine the at least two sets of the plurality of sets of digital data to generate a pre-compression set of digital data and simultaneously compress the pre-compression set of digital data simultaneously or together in a single compression operation.
FILED Tuesday, December 22, 2020
APPL NO 17/131191
CURRENT CPC
Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking
B07C 3/14 (20130101)

Image Data Processing or Generation, in General
G06T 7/13 (20170101)
G06T 9/20 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210194782 JUMP et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Theodore A. JUMP (Raleigh, North Carolina);  Jennifer S. MULHERIN (Morrisville, North Carolina)
ABSTRACT A computer-implemented method includes selecting, by a host endpoint device within a subnet, a test endpoint device, of a plurality of test endpoint devices within the subnet, with which to perform a connectivity performance quality test; determining, by the host endpoint device, a payload size for a test file to be used for performing a network throughput test as part of the connectivity performance quality test; performing, by the host endpoint device, the connectivity performance quality test with the test endpoint device, wherein performing the connectivity performance quality test comprises performing a plurality of network throughput tests using the test file having the payload size that was determined; and providing, by the host endpoint device, results data from the connectivity performance quality test to a central network administration device, whereby the central network administration device executes a computer-based instruction based on the results data from the connectivity performance quality test.
FILED Thursday, December 17, 2020
APPL NO 17/125472
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 41/12 (20130101)
H04L 43/50 (20130101)
H04L 43/087 (20130101)
H04L 43/0811 (20130101) Original (OR) Class
H04L 43/0864 (20130101)
H04L 43/0888 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 20210187474 SHAIKH et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) XPLOSAFE, LLC (Stillwater, Oklahoma)
ASSIGNEE(S) XPLOSAFE, LLC (Stillwater, Oklahoma)
INVENTOR(S) Shoaib F. SHAIKH (Stillwater, Oklahoma);  Allen W. APBLETT (Stil