FedInvent Patent Applications
Patent Application Details for Thursday, July 01, 2021
This page was updated on Saturday, July 17, 2021 at 01:40 AM GMT
Department of Health and Human Services (HHS)
| US 20210195879 | Howell et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine); Indiana University Research and Technology Corporation (Indianapolis, Indiana); Sage Bionetworks (Seattle, Washington) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine); Indiana University Research and Technology Corporation (Indianapolis, Indiana); Sage Bionetworks (Seattle, Washington) |
| INVENTOR(S) | Gareth Howell (Bar Harbor, Maine); Gregory Carter (Bar Harbor, Maine); Michael Sasner (Bar Harbor, Maine); Stacey Rizzo (Bar Harbor, Maine); Harriet Williams (Bar Harbor, Maine); Bruce Lamb (Carmel, Indiana); Paul Territo (Fishers, Indiana); Adrian Oblak (Fishers, Indiana); Ben Logsdon (Seattle, Washington); Lara Mangravite (Seattle, Washington); Leah Graham (Bar Harbor, Maine) |
| ABSTRACT | The present disclosure provides a genetically modified mouse comprising a genomic nucleic acid encoding human APOE4, a genomic nucleic acid encoding mouse TREM2 modified to include a R47H substitution, and at least one genomic modification selected from the group consisting of: (a) a genomic nucleic acid encoding mouse ABCA7 modified to include an A 1541 G substitution; (b) a genomic nucleic acid encoding mouse APP modified to include G601R, F606Y, and R609H substitutions; (c) a genomic nucleic acid encoding mouse PLCG2 modified to include a M28L substitution; (d) a genomic nucleic acid encoding mouse MTHFR modified to include a A262V substitution; (e) an inactivated Ceacam1 allele; and (f) an inactivated Il1rap allele. Methods of producing the genetically modified mouse and methods of using the genetically modified mouse are also provided. |
| FILED | Friday, June 21, 2019 |
| APPL NO | 17/253473 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Original (OR) Class A01K 2217/15 (20130101) A01K 2217/072 (20130101) A01K 2227/105 (20130101) A01K 2267/0312 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0008 (20130101) Peptides C07K 14/775 (20130101) C07K 14/70503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/0028 (20130101) Enzymes C12Y 105/0102 (20130101) C12Y 301/04011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210195891 | Uygun et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mustafa Korkut Uygun (Newton, Massachusetts); Shannon Noella Tessier (Framingham, Massachusetts); Renier Johan de Vries (Boston, Massachusetts) |
| ABSTRACT | This disclosure is related to methods of preserving biological samples such as organs, and tissue. The present disclosure relates to methods of subzero preservation of biological tissue samples, such as entire organs from mammals, e.g., humans. The present disclosure is based, at least in part, on the discovery that biological tissue samples can be supercooled while minimizing formation of ice crystals by reducing liquid-air interfaces and lowering the melting point of the tissue samples, e.g., organs, or liquid in the tissue samples by use of cryoprotective agents while ensuring uniform distribution of cryoprotective agents throughout the biological sample by using improved perfusion techniques. |
| FILED | Thursday, May 30, 2019 |
| APPL NO | 17/058279 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) A01N 1/0284 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196126 | PAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF THE NEW YORK (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingtian PAN (Stony Brook, New York); Wei CHEN (Stony Brook, New York); Congwu DU (Stony Brook, New York) |
| ABSTRACT | An exemplary system, method, and computer-accessible medium for generating an image(s) of an three-dimensional anatomical flow map(s) can include receiving an optical coherence tomography (“OCT”) signal(s), splitting the OCT signal(s) into a plurality of subspectra, averaging the plurality of subspectra, and generating the image(s) of the three-dimensional anatomical flow map(s) based on the averaged subspectra. The OCT signal(s) can be a swept-source OCT signal. The OCT signal(s) can be split into the subspectra based on a Hamming window. The Hamming distance window can be optimized to minimize a nearest side lobe for each of the subspectra. A position of at least one of the subspectra can be shifted prior to averaging the subspectra. The position of all but one of the subspectra can be shifted prior to averaging the subspectra. |
| FILED | Friday, October 12, 2018 |
| APPL NO | 16/755702 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/026 (20130101) A61B 5/0066 (20130101) Original (OR) Class A61B 5/0075 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02004 (20130101) G01B 9/02044 (20130101) G01B 9/02083 (20130101) G01B 9/02091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196211 | Tai et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yuan-Chuan Tai (St. Louis, Missouri); Joseph O'Sullivan (St. Louis, Missouri); Ke Li (St. Louis, Missouri); Qiang Wang (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Yuan-Chuan Tai (St. Louis, Missouri); Joseph O'Sullivan (St. Louis, Missouri); Ke Li (St. Louis, Missouri); Qiang Wang (St. Louis, Missouri) |
| ABSTRACT | A positron emission tomography (PET) technique that can enhance the image resolution and system sensitivity of a clinical PET/CT scanner for imaging a whole body or a target region of a subject is provided. The system includes a detector array and a detector panel. The detector array includes an array of gamma ray detectors defining a field of view of a scanner and configured to detect at least one coincidence event. The detector panel includes an array of gamma ray detectors having a higher intrinsic spatial resolution than the detector array and positioned in closer proximity to a patient table than the detector array. The detector panel is positioned outside the field of view defined by the detector array during at least a portion of scanning by the PET system. The detector panel is configured to detect at least one coincidence event in cooperation with the detector array. The control unit is configured to control the detector array, the detector panel, and the patient bed to operate in cooperation with each other. |
| FILED | Wednesday, November 27, 2019 |
| APPL NO | 16/697722 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/037 (20130101) Original (OR) Class A61B 6/4233 (20130101) Measurement of Nuclear or X-radiation G01T 1/2985 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196215 | SIEWERDSEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
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| INVENTOR(S) | JEFFREY H. SIEWERDSEN (BALTIMORE, Maryland); WOJCIECH ZBIJEWSKI (BALTIMORE, Maryland); ALEJANDRO SISNIEGA (BALTIMORE, Maryland); JOSEPH WEBSTER STAYMAN (BALTIMORE, Maryland) |
| ABSTRACT | The present invention is directed to a method of multi-motion compensation for high-quality cone-beam CT of the head. A multi-stage approach is incorporated that includes a pre-conditioning stage in which an initial estimation of the motion trajectory is obtained with 3D-2D registration using the motion-contaminated CBCT and projection data. In the present invention, the motion-contaminated CBCT is used as a basis for 3D-2D registration in the pre-conditioning stage to capture large amplitude, rapid movements of the head and provide better initialization of the autofocus solution. |
| FILED | Friday, May 17, 2019 |
| APPL NO | 17/056639 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/501 (20130101) A61B 6/4021 (20130101) Original (OR) Class A61B 6/4085 (20130101) A61B 6/5205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196229 | BOCTOR et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emad M. BOCTOR (Ellicott City, Maryland); Chloe AUDIGIER (Baltimore, Maryland); Younsu KIM (Baltimore, Maryland); Emran ANAS (Baltimore, Maryland); Arman RAHMIM (Baltimore, Maryland); Nicholas P.K. ELLENS (Baltimore, Maryland); Xiaoyu GUO (Baltimore, Maryland) |
| ABSTRACT | A system for monitoring an ablation therapy may include an ultrasound transmitter to transmit ultrasound signals through a region of tissue during an ablation procedure, an ultrasound receiver to receive the ultrasound signals after the ultrasound signals have passed through the region of tissue, and a signal processor to communicate with the ultrasound transmitter and the ultrasound receiver to obtain a set of measurements related to the ultrasound signals transmitted through the region of tissue during the ablation procedure. The signal processor may determine one or more acoustic characteristics of the ultrasound signals transmitted through the region of tissue based on the set of measurements and generate an image representing a thermal map of the region of tissue during the ablation procedure based on a mapping between the one or more acoustic characteristics of the ultrasound signals and changes in temperature. |
| FILED | Wednesday, May 29, 2019 |
| APPL NO | 17/057542 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) Original (OR) Class A61B 8/145 (20130101) A61B 8/485 (20130101) A61B 8/5223 (20130101) A61B 18/00 (20130101) A61B 2018/00577 (20130101) A61B 2018/00803 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196666 | Garkavtsev et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor Garkavtsev (Cambridge, Massachusetts); Rakesh K. Jain (Wellesley, Massachusetts) |
| ABSTRACT | This invention relates to compounds that are useful for inhibiting the secretion of secretory leukocyte protease inhibitor (SLPI) in a subject. Methods of inhibiting metastasis of cancer and methods of treating cancer in a subject are also provided. |
| FILED | Tuesday, October 09, 2018 |
| APPL NO | 16/754912 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/245 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196673 | Hsu |
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| FUNDED BY |
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| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| ASSIGNEE(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| INVENTOR(S) | Stephen D. Hsu (Evans, Georgia) |
| ABSTRACT | Modified green tea polyphenol compositions and their methods of use in treating and preventing SARS-CoV-2 infections are provided. An exemplary green tea polyphenol composition includes (−)-epigallocatechin-3-gallate that can be esterified with a C1-C30 group in at least one position and a carrier such as glycerol. The modified green tea polyphenol compositions can be used to treat and prevent SARS-CoV-2 infections without coming into contact with the viral cell. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/182425 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0073 (20130101) A61K 31/353 (20130101) Original (OR) Class A61K 47/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196679 | VIDYASAGAR et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sadasivan VIDYASAGAR (Gainesville, Florida); Paul OKUNIEFF (Gainesville, Florida); Lurong ZHANG (Gainesville, Florida) |
| ABSTRACT | The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/161811 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0095 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/405 (20130101) Original (OR) Class A61K 31/7004 (20130101) A61K 31/7016 (20130101) A61K 47/20 (20130101) A61K 47/183 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196684 | Pepe et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Antonella Pepe (West Lafayette, Indiana); Andrew Mesecar (West Lafayette, Indiana) |
| ABSTRACT | The present invention generally relates to 6-amino-2,4-dihydropyrano[2,3-c] pyrazoles as a ubiquitin specific protease 7 (USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/199559 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4162 (20130101) Original (OR) Class A61K 45/06 (20130101) Heterocyclic Compounds C07D 491/052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196695 | MCCORMICK et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Leidos Biomedical Research, Inc. (Frederick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank MCCORMICK (San Francisco, California); Adam R. Renslo (Oakland, California); David Turner (Frederick, Maryland); Stephan Gysin (Basel, Switzerland); Anna E. Maciag (Frederick, Maryland); Oleg Chertov (Frederick, Maryland) |
| ABSTRACT | Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/082125 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/445 (20130101) Original (OR) Class A61K 47/545 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 207/16 (20130101) C07D 211/28 (20130101) C07D 211/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196713 | Lairson et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California); Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Luke L. Lairson (San Diego, California); Michael J. Bollong (San Diego, California); Peter G. Schultz (La Jolla, California); Sendurai A. Mani (Houston, Texas) |
| ABSTRACT | The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin. |
| FILED | Tuesday, October 30, 2018 |
| APPL NO | 15/733051 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/497 (20130101) A61K 31/502 (20130101) Original (OR) Class A61K 31/551 (20130101) A61K 31/4704 (20130101) A61K 31/4741 (20130101) A61K 31/4985 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196716 | BESIRLI et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
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| INVENTOR(S) | Cagri Giray BESIRLI (Ann Arbor, Michigan); Thomas WUBBEN (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are compositions and methods for treating eye disorders. In particular, provided herein are neuroprotective compositions and methods for treating vision loss and related disorders. |
| FILED | Thursday, October 18, 2018 |
| APPL NO | 16/757179 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 31/5025 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196745 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mei Zhang (Cleveland, Ohio); Alex Y. Huang (Cleveland, Ohio); Julian Kim (Cleveland, Ohio) |
| ABSTRACT | A method of treating a subject having cancer is described that includes administering a therapeutically effective amount of a β-(1,3)-(1,4) glucan to the subject. Methods of immunostimulating in a subject by administering an effective amount of a β-(1,3)-(1,4) glucan to the subject are also described. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172150 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/716 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196750 | Vivas-Mejia et al. |
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| FUNDED BY |
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| APPLICANT(S) | Pablo Vivas-Mejia (San Juan, Puerto Rico); Nilmary Grafals (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pablo Vivas-Mejia (San Juan, Puerto Rico); Nilmary Grafals (San Juan, Puerto Rico) |
| ABSTRACT | The present invention discloses targeting microRNAs as a potential therapeutic target for cancer, more particularly glioblastoma (GBM). It discloses targeting microRNAs with gold-nanoliposomes labeled with brain targeting-peptides inducing a significant cell growth arrest and inhibition of miRNA-92b, an aberrantly abundant miRNA found in GBM cells. Furthermore, it delivers gold-nanoliposomes to the brain by crossing the blood brain barrier (BBB) and reaching cancer tumors. |
| FILED | Monday, October 05, 2020 |
| APPL NO | 17/063423 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1275 (20130101) A61K 33/242 (20190101) Original (OR) Class A61K 47/62 (20170801) A61K 47/6911 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196755 | Powell |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. Powell (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | The invention provides compositions and methods for overcoming poor response to antibody therapy, for example, antibody resistance. The invention also relates to at least one immune receptor (IR) specific to the Fc receptor, vectors comprising the same, and recombinant T cells comprising the Fc immune receptor. The invention also includes methods of administering a modified T cell expressing an immune receptor that comprises a Fc binding domain. |
| FILED | Tuesday, August 11, 2020 |
| APPL NO | 16/990421 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 39/0011 (20130101) A61K 39/001102 (20180801) A61K 39/3955 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70535 (20130101) C07K 14/70578 (20130101) C07K 16/30 (20130101) C07K 16/32 (20130101) C07K 16/2863 (20130101) C07K 16/2887 (20130101) C07K 16/2893 (20130101) C07K 16/3069 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196757 | Wu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chia-Yung Wu (San Francisco, California); James Onuffer (Alameda, California); Wendell A. Lim (San Francisco, California) |
| ABSTRACT | The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided. |
| FILED | Tuesday, December 08, 2020 |
| APPL NO | 17/115565 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 47/6891 (20170801) A61K 2039/505 (20130101) Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70575 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2803 (20130101) C07K 16/2866 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/14 (20130101) C12N 9/90 (20130101) Enzymes C12Y 502/01008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196771 | KIEFER et al. |
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| FUNDED BY |
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| APPLICANT(S) | SYSTEMS ONCOLOGY, LLC (Scottsdale, Arizona); MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| ASSIGNEE(S) | SYSTEMS ONCOLOGY, LLC (Scottsdale, Arizona); MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| INVENTOR(S) | Jeff KIEFER (Scottsdale, Arizona); Ramon MORENO (Scottsdale, Arizona); Spyro MOUSSES (Scottsdale, Arizona); Eric BARTEE (John's Island, South Carolina) |
| ABSTRACT | The present disclosure provides a recombinant oncolytic virus engineered to express a soluble form of an immune checkpoint protein. In certain aspects, the oncolytic vims is a replication competent virus such as myxoma vims. Methods of cancer treatment comprising administering the recombinant oncolytic virus expressing the soluble form of the immune checkpoint protein are also provided. |
| FILED | Friday, August 16, 2019 |
| APPL NO | 17/268656 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/768 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/55 (20130101) C07K 14/5434 (20130101) C07K 14/70521 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196782 | Lee et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yeon Sun Lee (Tucson, Arizona); Victor J. Hruby (Tucson, Arizona); Frank Porreca (Tucson, Arizona) |
| ABSTRACT | Opioid receptor ligands (ORLs) that are multifunctional having agonist activity at mu opioid receptor (MOR), agonist activity at delta opioid receptor (DOR), and antagonist (or partial agonist) activity at kappa opioid receptor (KOR) are for the treatment of pain. The ORLs comprise peptide portions that are analogs derived from enkephalins, endomorphins, or [DArg2, Lys4]-dermorphine (DALDA), as well as tail portions that comprise a lipophilic molecule such as a 4-anilidopiperidine moiety. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197980 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196797 | Wagner |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Amy Kathleen Wagner (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure relates to methods, compositions, and kits for treating traumatic brain injury (TBI) and TBI-associated impairments in a subject. The methods include administering to the subject an interleukin-7 (IL-7) or IL-7 agonist, a TNFα inhibitor, or both. The present disclosure also relates to methods of using biomarkers for identifying a subject that is likely to respond to a treatment for TBI-associated impairments, and monitoring the subject's response to such treatment. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135970 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2046 (20130101) Original (OR) Class Peptides C07K 16/241 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/70578 (20130101) G01N 2800/28 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196812 | Amanna et al. |
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| FUNDED BY |
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| APPLICANT(S) | Najít Technologies, Inc. (Beaverton, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ian J. Amanna (Hillsboro, Oregon); Elizabeth A. Poore (Portland, Oregon) |
| ABSTRACT | Provided are methods for rapidly inactivating a pathogen, or for producing a vaccine composition containing an inactivated noninfectious pathogen having retained antigenicity and/or immunogenicity, comprising exposing the pathogen to a chemical inactivating agent (e.g., one or more chemical oxidizing, alkylating or crosslinking agents) in the presence of inorganic polyatomic oxyanions in an amount and for a time sufficient to render the pathogen noninfectious while enhancing retention of pathogen antigenicity and/or immunogenicity relative to that retained by contacting the pathogen with the chemical inactivating agent alone. The methods are broadly applicable to pathogens having RNA or DNA genomes (e.g., including viruses, bacteria, fungi, and parasites). Also provided are vaccine compositions (medicaments) containing a pathogen inactivated by exposure to an inactivating agent in the presence of elevated concentrations of inorganic polyatomic oxyanions, and methods for eliciting an immune response in a subject by administering the vaccine compositions. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 16/994500 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/40 (20130101) A61K 39/02 (20130101) A61K 39/12 (20130101) A61K 39/105 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 39/275 (20130101) A61K 39/0283 (20130101) A61K 2039/521 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196830 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Baker (Austin, Texas); Anthony Monteforte (Austin, Texas) |
| ABSTRACT | Disclosed herein are proteovesicles, referred to herein as a “glypisomes”, that comprise a recombinant glypican polypeptide embedded in a lipid vesicle. Also disclosed is the use of these glypisomes to enhance the activity of growth factors. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/174641 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/107 (20130101) A61K 9/1272 (20130101) A61K 9/1652 (20130101) A61K 9/5036 (20130101) A61K 38/18 (20130101) A61K 38/30 (20130101) A61K 38/185 (20130101) A61K 38/1709 (20130101) A61K 38/1825 (20130101) A61K 38/1858 (20130101) A61K 38/1866 (20130101) A61K 47/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196837 | Ensign et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laura Ensign (Towson, Maryland); Justin Hanes (Baltimore, Maryland); Abhijit Date (Baltimore, Maryland); Yoo Chun Kim (Odenton, Maryland) |
| ABSTRACT | Hypotonic gelling vehicles are used as solubilizing agents for drugs and as a means to provide sustained drug delivery to a mucosal tissue. Solubilizing drugs at higher concentrations enhances drug penetration into the tissues of the body, while the hypotonic gelling vehicle further improves distribution of the drug over a larger surface area for increased absorption and sustained release for reduced side effects and longer duration of action. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193896 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0048 (20130101) A61K 31/404 (20130101) A61K 31/473 (20130101) A61K 47/6903 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196839 | Meruelo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Meruelo (Scarborough, New York); Tomer Granot (Brooklyn, New York); Yoshihide Yamanashi (Brooklyn, New York) |
| ABSTRACT | The subject application is directed to a method for treating a mammal harboring a tumor comprising identifying a tumor associated antigen (TAA) expressed by the tumor and parenterally administering to the mammal a therapeutically effective amount of a Sindbis viral vector carrying a gene encoding the TAA to the mammal sufficient to elicit an immune response directed against the tumor, and thereby treating the tumor. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195236 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/001182 (20180801) A61K 39/001188 (20180801) A61K 48/0058 (20130101) Original (OR) Class A61K 2039/572 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/36143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196856 | Boyden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Stuart Boyden (Chestnut Hill, Massachusetts); Nikita Obidin (Somerville, Massachusetts); Ruixuan Gao (Cambridge, Massachusetts); Linyi Gao (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides a method for preparing an expanded cell or tissue sample suitable for microscopic analysis. Expanding the sample can be achieved by binding, e.g., anchoring, key biomolecules to a DMAA-TF polymer network and swelling, or expanding, the polymer network, thereby moving the biomolecules apart as further described herein. As the biomolecules are anchored to the polymer network isotropic expansion of the polymer network retains the spatial orientation of the biomolecules resulting in an expanded, or enlarged, sample. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/144551 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) Original (OR) Class A61L 27/56 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/56 (20130101) Compositions of Macromolecular Compounds C08L 33/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/312 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196863 | Segura et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Tatiana Segura (Durham, North Carolina); Lina R. Nih (Los Angeles, California); Elias Sideris (Pasadena, California) |
| ABSTRACT | A hydrogel material for the treatment of stroke or other brain injury includes a collection of hyaluronic acid-based microgel particles comprising one or more network crosslinker components, wherein the hyaluronic acid-based microgel particles, when exposed to an endogenous annealing agent (e.g., Factor XIIIa), links the hyaluronic acid-based microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. The hydrogel material may be injected into a stroke cavity and was shown to promote brain tissue repair by promoting the recruitment of neural stem cells to the injured site and reducing the post-stroke inflammatory response. |
| FILED | Wednesday, February 01, 2017 |
| APPL NO | 16/075100 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/52 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 2300/42 (20130101) A61L 2300/414 (20130101) A61L 2300/622 (20130101) A61L 2400/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196935 | TONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MORNINGSIDE VENTURE INVESTIMENTS LIMITED (Monaco, Monaco) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ling-Kang TONG (Hayward, California); Daniela Tamar BUCHMAN (Mountain View, California); Jackie Joe HANCOCK (Berkeley, California); Nicholas TERZULLI (Oakland, California) |
| ABSTRACT | A two-part bioactive agent delivery system includes a disposable part, a reusable part, and a solvent removal element. The disposable part includes an agent reservoir, a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user. The transdermal patch has a bottom surface adapted to contact skin of the user, a top surface opposite the bottom surface, and a gas permeable membrane disposed over the top surface of the transdermal patch. The reusable part includes a power source and control electronics that are adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch. The solvent removal element includes a gap disposed between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system. |
| FILED | Wednesday, May 29, 2019 |
| APPL NO | 17/057318 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 35/10 (20190501) Original (OR) Class A61M 2205/14 (20130101) A61M 2205/0272 (20130101) A61M 2205/8206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196937 | McALLISTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Devin V. McALLISTER (Marietta, Georgia); Mark R. PRAUSNITZ (Atlanta, Georgia); Sebastien HENRY (Smyrna, Georgia) |
| ABSTRACT | Drug delivery devices and methods are provided for delivering one or more drugs into a biological tissue. The devices include microneedles that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release. Methods for delivery drug with microneedles also are provided. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184140 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0007 (20130101) A61M 2037/0023 (20130101) A61M 2037/0046 (20130101) A61M 2037/0061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196939 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Wang (State College, Pennsylvania); James Coyne (State College, Pennsylvania); David Kauffman (Ambler, Pennsylvania); Brandon Davis (Yardley, Pennsylvania) |
| ABSTRACT | A method of providing therapeutic treatment by delivering therapeutic aptamers locally to a target site using microneedles includes providing complementary sequence modified microneedles by reacting a complementary sequence (CS) with a polymer thereby forming a covalent bond between the polymer and the CS, forming microneedle patches using an initial casting solution consisting of the polymer, the therapeutic aptamer, and a covalent bond between a complementary sequence (CS) and the polymer, thereby loading the therapeutic aptamer into the microneedles, each microneedle having a base, shaft and tip, physically binding the therapeutic aptamer to the CS, inserting the microneedles into the tissue such that the tips and shafts are embedded into the target site and the bases are on a surface of the target site, and sustained release of the aptamer to the target site due to dissociation of the aptamer from the CS over time. |
| FILED | Tuesday, August 27, 2019 |
| APPL NO | 17/271486 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) A61K 38/1866 (20130101) A61K 47/32 (20130101) A61K 47/61 (20170801) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0023 (20130101) A61M 2037/0046 (20130101) A61M 2210/125 (20130101) A61M 2210/0612 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196955 | Kressel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Feinstein Institutes for Medical Research (Manhasset, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam M. Kressel (Plainview, New York); Valentin A. Pavlov (Bayside, New York); Sangeeta S. Chavan (Syosset, New York); Kevin J. Tracey (Old Greenwich, Connecticut) |
| ABSTRACT | Methods for electrical modulation of inflammation or serum TNF levels in a subject. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184197 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0412 (20130101) A61N 1/0504 (20130101) A61N 1/0536 (20130101) A61N 1/3615 (20130101) A61N 1/36053 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210197194 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178824 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 2400/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210197202 | Zayac et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Combinati Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Zayac (Belmont, California); Sammy Datwani (Pleasanton, California); Megan Dueck (San Francisco, California); Ju-Sung Hung (Palo Alto, California) |
| ABSTRACT | The present disclose provides devices, methods and systems that may be used for amplifying and quantifying nucleic acid molecules. Methods for amplifying and quantifying nucleic acids may comprise isolating a sample comprising nucleic acid molecules into a plurality of chambers, performing a polymerase chain reaction on the plurality of chambers, and analyzing the results of the polymerase chain reaction. |
| FILED | Tuesday, September 22, 2020 |
| APPL NO | 17/028839 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 7/52 (20130101) Original (OR) Class B01L 2200/0689 (20130101) B01L 2300/18 (20130101) B01L 2300/0609 (20130101) B01L 2300/0663 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198196 | Schnermann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Martin John Schnermann (Rockville, Maryland); Michael Philip Luciano (Frederick, Maryland); Roger Rauhauser Nani (Frederick, Maryland) |
| ABSTRACT | Heptamethine cyanine fluorophore conjugates and conjugate precursors are disclosed. Methods of using the conjugates and conjugate precursors are also disclosed. The disclosed conjugates are neutral zwitterionic molecules and exhibit little or no aggregation. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/179217 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0058 (20130101) Heterocyclic Compounds C07D 209/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/533 (20130101) G01N 33/582 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198238 | BACKES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattie, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley BACKES (San Francisco, California); Feroz R. PAPA (San Francisco, California); Scott Andre OAKES (San Francisco, California); Dustin J. MALY (Seattle, Washington) |
| ABSTRACT | Disclosed herein are, inter alia, compounds modulating Inositol-Requiring Enzyme 1α (IRE1α) and IRE1β activity and methods of use thereof for treating IRE1α-mediated and IRE1β-mediated disorders. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/271363 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198254 | MILLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| ASSIGNEE(S) | UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Indiana) |
| INVENTOR(S) | Marvin J. MILLER (South Bend, Indiana); Garrett C. MORASKI (Bozeman, Montana) |
| ABSTRACT | Described herein are compounds and compositions, and methods of making and their use as effective agents against mycobacterial infections. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135927 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 513/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198265 | Emrick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd Emrick (South Deerfield, Massachusetts); Matthew Skinner (Amherst, Massachusetts); Sarah M. Ward (Amherst, Massachusetts); Banishree Saha (Greenfield, Massachusetts) |
| ABSTRACT | A temozolomide compound according to formula (I) is described, wherein R1, L1, and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188162 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/787 (20130101) A61K 47/58 (20170801) A61K 47/60 (20170801) A61K 47/545 (20170801) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 22/10 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198266 | Cousins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott W. Cousins (Durham, North Carolina); Priyatham S. Mettu (Durham, North Carolina); David M. Gooden (Durham, North Carolina) |
| ABSTRACT | The presently disclosed subject matter is directed to compositions and methods for treating CaMKK2-mediated ophthalmic diseases, including but not limited to 1) ocular surface inflammatory diseases (OSIDs), including but not limited to ocular graft versus host disease, ocular cicatricial pemphigoid, vernal keratoconjunctivitis, allergic eye disease, meibomian gland dysfunction, aqueous tear deficiency (common dry eye disease), corneal scarring, and conjunctival scarring and fibrosis; 2) uveitis and other inflammatory diseases of the eye, including but not limited to keratitis, scleritis, iritis, iridocyclitis, intermediate uveitis, pars planitis, posterior uveitis, choroiditis, chorioretinitis, retinitis, or panuveitis of noninfectious, infectious, or idiopathic etiologies; and 3) “back of the eye” retinal diseases, which include dry age-related macular degeneration, neovascular age-related macular degeneration, diabetic retinopathy, retinal vascular diseases (e.g. retinal vein occlusion, retinal artery occlusion), and retinal degenerations and dystrophies, in a subject. Particularly, the disclosed compounds exhibit improvements over STO-609, a well characterized specific inhibitor of CaMKK2. The disclosed compounds exhibit enhanced aqueous solubility and formulation, as well as elimination of non-binding isomers during production. The disclosed inhibitor compounds can be used to effectively treat ophthalmic diseases, cancers, appetite disorders, systemic inflammatory diseases, and the like. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269830 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 37/06 (20180101) Heterocyclic Compounds C07D 471/06 (20130101) C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198279 | EBRIGHT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| ASSIGNEE(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| INVENTOR(S) | Richard H. EBRIGHT (New Brunswick, New Jersey); Yon W. EBRIGHT (New Brunswick, New Jersey); Chih-Tsung LIN (New Brunswick, New Jersey) |
| ABSTRACT | The invention provides bipartite, dual-targeted inhibitors of bacterial RNA polymerase having the general structural formula (I): X-α-Y (I) wherein X is an moiety that binds to the Rif target of a bacterial RNA polymerase; Y is a moiety that binds to the bridge-helix N-terminus target of a bacterial RNA polymerase; and is a covalent bond or a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/058589 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Heterocyclic Compounds C07D 498/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198284 | YAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingdi YAN (Lowell, Massachusetts); Bin WU (Lowell, Massachusetts); William G. NDUGIRE (Lowell, Massachusetts); Olof RAMSTROM (Lowell, Massachusetts) |
| ABSTRACT | Gold compounds and pharmaceutically acceptable salts thereof are disclosed. Certain compounds and salts are active as antibacterial, antifungal, and/or anti-parasitic agents. The disclosure provides pharmaceutical compositions containing the gold compounds. Methods of using the gold compounds to treat bacterial infections are disclosed. |
| FILED | Friday, August 16, 2019 |
| APPL NO | 17/268845 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198288 | BURNS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VenatoRx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. BURNS (Malvern, Pennsylvania); Denis DAIGLE (Street, Maryland); Guo-Hua CHU (Exton, Pennsylvania); Jodie HAMRICK (New Holland, Pennsylvania); Steven A. BOYD (Chester Springs, Pennsylvania); Allison L. ZULLI (Chesterbrook, Pennsylvania); Eugen F. MESAROS (Wallingford, Pennsylvania); Stephen M. CONDON (Glenmoore, Pennsylvania); Robert E. Lee TROUT (Collegeville, Pennsylvania); Cullen L. MYERS (Exton, Pennsylvania); Zhenrong XU (Chalfont, Pennsylvania) |
| ABSTRACT | Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057593 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198321 | CAPONE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| ASSIGNEE(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| INVENTOR(S) | Stefania CAPONE (Rome, Italy); Antonella FOLGORI (Rome, Italy); Armin LAHM (Rome, Italy); Benjamin WIZEL (Rockville, Maryland) |
| ABSTRACT | The invention provides Epstein-Barr Virus antigen polynucleotides, polypeptides and vectors; as well as immunogenic compositions comprising the same. It includes the use of Epstein-Barr Virus antigen constructs to produce vaccines for treating and preventing Epstein-Barr Virus infections and Epstein-Barr Virus-associated diseases, such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. |
| FILED | Friday, December 14, 2018 |
| APPL NO | 16/770963 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/245 (20130101) A61K 2039/70 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16222 (20130101) C12N 2710/16234 (20130101) C12N 2710/16271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198323 | DURBIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York); RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York); RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| INVENTOR(S) | Joan E. DURBIN (Sergeantsville, New Jersey); Russell K. DURBIN (Sergeantsville, New Jersey); Adolfo GARCIA-SASTRE (New York, New York); Ignacio MENA (New York, New York); Peter PALESE (New York, New York) |
| ABSTRACT | Described herein are recombinant Newcastle disease viruses (“NDVs”) comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a respiratory syncytial virus (“RSV”) F protein or human metapneumovirus (“hMPV”) F protein. Also described herein are recombinant NDVs comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a chimeric F protein, wherein the chimeric F protein comprises (i) an RSV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains; or (ii) an hMPV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains. The recombinant NDVs and compositions thereof are useful for the immunizing against RSV or hMPV as well as the prevention of RSV disease or hMPV disease. |
| FILED | Friday, August 16, 2019 |
| APPL NO | 17/268403 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/08 (20130101) Original (OR) Class C07K 16/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198324 | Kwong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Peter Kwong (Washington, District of Columbia); Ivelin Georgiev (Nashville, Tennessee); Michael Gordon Joyce (Washington, District of Columbia); Masaru Kanekiyo (Chevy Chase, Maryland); Aliaksandr Druz (Germantown, Maryland); Ulrich Baxa (Frederick, Maryland); Joseph Van Galen (North Wales, Pennsylvania); Cheng Cheng (Rockville, Maryland); John Mascola (Rockville, Maryland); Yaroslav Tsybovsky (Brunswick, Maryland); Yongping Yang (Potomac, Maryland); Barney Graham (Rockville, Maryland); Syed Mohammad Moin (Bethesda, Maryland); Jeffrey Boyington (Clarksburg, Maryland) |
| ABSTRACT | Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/202231 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) A61K 2039/55555 (20130101) Peptides C07K 14/11 (20130101) Original (OR) Class C07K 14/082 (20130101) C07K 14/162 (20130101) C07K 14/165 (20130101) C07K 14/43563 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198330 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Luke W. Koblan (Cambridge, Massachusetts); Christopher Gerard Wilson (Cambridge, Massachusetts); Jordan Leigh Doman (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. The disclosure provides fusion proteins of nucleic acid programmable DNA binding proteins (napDNAbp), e.g., Cas9 or variants thereof, and nucleic acid editing proteins such as cytidine deaminase domains (e.g., novel cytidine deaminases generated by ancestral sequence reconstruction), and adenosine deaminases that deaminate adenine in DNA. Aspects of the disclosure relate to fusion proteins (e.g., base editors) that have improved expression and/or localize efficiently to the nucleus. In some embodiments, base editors are codon optimized for expression in mammalian cells. In some embodiments, base editors include multiple nuclear localization sequences (e.g., bipartite NLSs), e.g., at least two NLSs. In some embodiments, methods for targeted nucleic acid editing are provided. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057398 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) Original (OR) Class C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) Enzymes C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198333 | Storkus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | Walter J. Storkus (Glenshaw, Pennsylvania); Michael S. Kinch (Laytonsville, Maryland) |
| ABSTRACT | EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative derivatives thereof. The EphA2 T-cell epitopes are useful in an assay, such as an ELISPOT assay, that may be used to determine and/or quantify a patient's immune responsiveness to EphA2. The epitopes also are useful in methods of modulating a patient's immune reactivity to EphA2, which has substantial utility as a treatment for cancers that overexpress EphA2, such as renal cell carcinoma (RCC). The EphA2 epitopes also can be used to vaccinate a patient against EphA2, by in vivo or ex vivo methods. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 16/997197 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1793 (20130101) A61K 39/0011 (20130101) A61K 2039/55566 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/47 (20130101) C07K 14/705 (20130101) C07K 14/4748 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/5091 (20130101) G01N 33/56966 (20130101) G01N 33/56972 (20130101) G01N 2333/57 (20130101) G01N 2333/5409 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198349 | Sigurdsson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | New York University (New York, New York) |
| INVENTOR(S) | Einar Sigurdsson (Scarsdale, New York) |
| ABSTRACT | The present invention relates to antibody-based molecules (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to the truncated Asp421 epitope of Tau. Such antibody-based molecules are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis and/or treatment of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The antibody-based molecules of the present invention have particular utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176374 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/532 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198370 | FAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Zhen FAN (Houston, Texas); Yang LU (Houston, Texas); Songho QIU (Houston, Texas) |
| ABSTRACT | The present disclosure provides a bispecific antibody comprising an IgG linked to an scFv, wherein the VH domain of the IgG is linked to the VH domain of the scFv, the bispecific antibody binding a human vascular endothelial growth factor (VEGF) family protein and an epidermal growth factor receptor (EGFR) family protein. Further embodiments provide pharmaceutical compositions comprising the bispecific antibody of the embodiments and aspects thereof and a pharmaceutically acceptable carrier. Further embodiments provide various methods of treating cancer in a subject comprising administering a bispecific antibody of the embodiments and aspects thereof to the subject. A further embodiment provides a kit comprising the bispecific antibody. |
| FILED | Friday, May 31, 2019 |
| APPL NO | 17/058414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/22 (20130101) C07K 16/2863 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198371 | Zou |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yimin Zou (La Jolla, California) |
| ABSTRACT | Methods for inhibiting degeneration of a neuron, methods of treating a neurological/neurodegenerative disease, methods of modulating the directional growth of a neuron, and methods of interfering with the interaction of Wnt and Ryk are provided herein. Also provided are isolated anti-Ryk antibodies and antibody fragments that specifically bind to a binding domain of Wnt. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127913 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/545 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/00 (20130101) C07K 16/28 (20130101) C07K 16/2863 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198410 | GAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jinming GAO (Plano, Texas); David BOOTHMAN (Deceased, None); Kejin ZHOU (Dallas, Texas); Xiaonan HUANG (Beijing, China PRC); Yiguang WANG (Dallas, Texas) |
| ABSTRACT | Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/198006 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 9/1273 (20130101) A61K 9/5031 (20130101) A61K 31/337 (20130101) A61K 31/352 (20130101) A61K 31/704 (20130101) A61K 47/58 (20170801) A61K 47/62 (20170801) A61K 47/6811 (20170801) A61K 47/6845 (20170801) A61K 47/6907 (20170801) A61K 49/005 (20130101) A61K 49/0032 (20130101) A61K 49/0054 (20130101) A61K 49/0056 (20130101) A61K 49/0082 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 311/92 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/34 (20130101) C08F 293/005 (20130101) Original (OR) Class C08F 299/024 (20130101) C08F 2438/01 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 81/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198516 | LOCKLIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason J. LOCKLIN (Bogart, Georgia); Qiaohong LIU (Athens, Georgia); Priyadarshini SINGHA (Athens, Georgia); Hitesh HANDA (Athens, Georgia); Jitendra PANT (Athens, Georgia); Marcus J GOUDIE (Athens, Georgia); Sean HOPKINS (Athens, Georgia) |
| ABSTRACT | Coating compositions, coated articles including the coating compositions, and methods of making the coating compositions and coated articles are provided. In some aspects, the coating compositions are applied to a substrate having nitric oxide-releasing properties. The coating compositions can include copolymers having crosslinking agents that can be activated with mild UV light (about 345 nm to 365 nm) to avoid damaging the substrate while creating strong covalent bonds to the substrate. The copolymers can include hydrophilic repeat units, and in particular zwitterionic repeat units such as repeat units containing phosphorylcholine groups. In some aspects, the coating compositions are applied to a surface of a polymer substrate, wherein the polymer substrate had nitric oxide releasing properties. The coating compositions and the coated articles can have antifouling, antithrombotic, and/or antibacterial properties. |
| FILED | Friday, October 19, 2018 |
| APPL NO | 16/757701 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/197 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/16 (20130101) A61L 29/085 (20130101) A61L 2300/21 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 133/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198607 | WIKSWO et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. WIKSWO (Brentwood, Tennessee); Eric C. SPIVEY (Nashville, Tennessee); David K. SCHAFFER (Nashville, Tennessee); Ronald S. REISERER (Nashville, Tennessee); Kevin T. SEALE (Nashville, Tennessee); Frank E. BLOCK, III (Potomac, Maryland) |
| ABSTRACT | One aspect of the invention provides a multichamber bioreactor. The multichamber bioreactor includes multiple planar layers stacked on each other defining at least one chamber and a clamping mechanism. The clamping mechanism includes a housing and retaining means received in the housing and configured to generate a controlled and uniform pressure to secure the stacked multiple planar layers in the housing. Each chamber is implemented from a separate fluidic layer, with each fluidic layer having ports and valves independent of the other layers. The micro fluidic ports can be actuated through a micro fluidic interconnect system utilizing rotary cylinder valves. |
| FILED | Wednesday, May 29, 2019 |
| APPL NO | 17/057267 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0247 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502715 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/44 (20130101) C12M 23/58 (20130101) C12M 29/00 (20130101) C12M 41/48 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/0045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198613 | Curley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AXOSIM, INC. (New Orleans, Louisiana); UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Lowry Curley (New Orleans, Louisiana); Michael James Moore (New Orelans, Louisiana); Corey Michael Rountree (New Orleans, Louisiana); Hieu Trung Nguyen (New Orleans, Louisiana); Swaminathan Rajaraman (Orlando, Florida); Avra Kundu (Orlando, Florida) |
| ABSTRACT | The present invention is directed to a microelectrode array for use in microengineered physiological systems and methods of using the same. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193589 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 41/46 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4836 (20130101) G01N 33/5014 (20130101) G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198619 | SURANA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neeraj K. SURANA (Boston, Massachusetts); Dennis Kasper (Brookline, Massachusetts) |
| ABSTRACT | In certain aspects, described herein are methods, bacteria, and compositions for the reduction of the amount, activity and/or proliferation of colonic group 3 innate lymphoid cells (ILC3s) and for the treatment and/or prevention of diseases associated with pathological immune responses, such as inflammatory bowel diseases. |
| FILED | Friday, June 22, 2018 |
| APPL NO | 16/625217 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 1/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198630 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | Rhode Island Hospital (Providence, Rhode Island); Rhode Island Hospital (Providence, Rhode Island) |
| INVENTOR(S) | Qian Chen (Barrington, Rhode Island); Chathuraka T. Jayasuriya (Barrington, Rhode Island) |
| ABSTRACT | This invention is directed to, inter alia, stable cartilage-derived progenitor cell lines as well as methods for producing stable cartilage-derived progenitor cell lines from diseased human cartilaginous tissues and lesions. Also provided herein are methods for using cartilage-derived progenitor cell lines for treatment of cartilage and bone degenerative diseases. |
| FILED | Tuesday, February 28, 2017 |
| APPL NO | 16/081029 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/32 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0655 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2740/10043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198634 | TSOKOS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George C. TSOKOS (Boston, Massachusetts); Abhigyan SATYAM (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods of growing podocytes in culture. Also provided are cell culture systems comprising decellularized extracellular matrix, tissue culture substrates, and podocytes. Further provided are podocytes produced by the methods and cell culture systems described herein and methods of using the podocytes. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/250791 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0686 (20130101) Original (OR) Class C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) G01N 2800/50 (20130101) G01N 2800/245 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198647 | Karamyan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vardan T. Karamyan (Amarillo, Texas); Paul Trippier (Papillion, Nebraska); David A. Ostrov (Gainesville, Florida); Tom Abbruscato (Amarillo, Texas); Srinidhi Jayaraman (Amarillo, Texas) |
| ABSTRACT | The present invention includes a composition and method of allosterically potentiating the activity of neurolysin comprising contacting the neurolysin with an amount of a histidine-containing dipeptide that is an allosteric that increases the activity of neurolysin. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186489 |
| CURRENT CPC | Peptides C07K 5/06147 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6416 (20130101) Original (OR) Class Enzymes C12Y 304/24016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198657 | Gao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| INVENTOR(S) | Jianmin Gao (Newton, Massachusetts) |
| ABSTRACT | Provided is a chemically modified phage display platform and method of use thereof. More specifically, the present disclosure provides a chemically modified phage display library that incorporates 2-acetylphenylboronic acid (APBA) moieties to elicit dynamic covalent binding to the bacterial cell surface. The APBA-modified phage display libraries described herein are applicable to a wide array of bacterial strains and/or mammalian cells, paving the way to facile diagnosis and development of strain-specific antibiotics, and/or peptide-antibiotic conjugates for effective and targeted treatment. Also provided are therapeutic peptides, and pharmaceutical compositions thereof, that are identified by screening the phage display library of the present disclosure, and method of use of such therapeutic peptides for effective and targeted treatment. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/156908 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/1037 (20130101) Original (OR) Class C12N 2795/00011 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198659 | Salathia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Illumina, Inc. (San Diego, California) |
| ASSIGNEE(S) | Illumina, Inc. (San Diego, California) |
| INVENTOR(S) | Neeraj Salathia (San Diego, California); Jian-Bing Fan (San Diego, California); Fiona Kaper (San Diego, California); Gordon M. Cann (San Diego, California); Arash Jamshidi (San Diego, California); Alex Aravanis (San Diego, California) |
| ABSTRACT | Presented herein are methods and compositions for multiplexed single cell gene expression analysis. Some methods and compositions include the use of droplets and/or beads bearing unique barcodes such as unique molecular barcodes (UMI). |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197836 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class C12N 15/1093 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6853 (20130101) C12Q 1/6869 (20130101) C12Q 2525/155 (20130101) C12Q 2525/161 (20130101) C12Q 2525/179 (20130101) C12Q 2525/191 (20130101) C12Q 2563/159 (20130101) C12Q 2563/179 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198669 | HEIER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's National Medical Center (Washington, District of Columbia) |
| ASSIGNEE(S) | Children's National Medical Center (Washington, District of Columbia) |
| INVENTOR(S) | Christopher HEIER (Washington, District of Columbia); Alyson FIORILLO (Washington, District of Columbia) |
| ABSTRACT | The present disclosure relates to compositions comprising an antisense RNA sequence comprising a region of complementarity that is substantially complementary to an miRNA. Pharmaceutical compositions comprising the antisense RNA molecule, optionally further comprising an anti-inflammatory corticosteroid are also disclosed. Methods of treating or preventing inflammation, a steroid side effect, or a muscle disease using the one or the pharmaceutical compositions are also disclosed. |
| FILED | Monday, June 03, 2019 |
| APPL NO | 17/059700 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2320/31 (20130101) C12N 2320/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198673 | Mali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (, None) |
| INVENTOR(S) | Prashant Mali (La Jolla, California); Dhruva Katrekar (La Jolla, California) |
| ABSTRACT | Aspects of the disclosure relate to a gene therapy approach for diseases, disorders, or conditions caused by mutation in the stop codon utilizing modified tRNA. At least 10-15% of all genetic diseases, including muscular dystrophy (e.g. Duchene muscular dystrophy), some cancers, beta thalassemia, Hurler syndrome, and cystic fibrosis, fall into this category. Not to be bound by theory, it is believed that this approach is safer than CRISPR approaches due to minimal off-target effects and the lack of genome level changes. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170671 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/78 (20130101) C12N 15/115 (20130101) Original (OR) Class Enzymes C12Y 305/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198688 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts) |
| ABSTRACT | Disclosed are methods and constructs for engineering circular RNA. Disclosed is a vector for making circular RNA, said vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, said vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. In another embodiment, the vector can comprise the 5′ spacer sequence, but not the 3′ spacer sequence. In yet another embodiment, the vector can comprise the 3′ spacer sequence, but not the 5′ spacer sequence. Also disclosed is a method for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191697 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198735 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia Guo (Tempe, Arizona); Joshua LaBaer (Chandler, Arizona) |
| ABSTRACT | Provided herein are methods and systems for sensitive and multiplexed in situ analysis of samples such as biological samples using cleavable hapten linked targeting agents and cleavable detectably-labeled hapten-binding agents. In particular, provided herein are methods for multiplexed single-cell in situ biomolecule profiling in samples, including fixed or fresh tissues, and also allows the investigation of the different cell compositions and their spatial organizations in intact tissues through consecutive cycles of probe hybridization, fluorescence imaging, and signal removal. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/138287 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2563/131 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198738 | Schwartz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Jewish Health (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Schwartz (Aurora, Colorado); Max Seibold (Denver, Colorado) |
| ABSTRACT | The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/091507 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/172 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/4725 (20130101) G01N 2800/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198739 | van der Maarel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); University of Rochester (Rochester, New York); Leiden University Medical Center (Leiden, Netherlands) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); University of Rochester (Rochester, New York); Leiden University Medical Center (Leiden, Netherlands) |
| INVENTOR(S) | Silvere M. van der Maarel (Leiden, Netherlands); Stephen J. Tapscott (Seattle, Washington); Rabi Tawil (Rochester, New York); Richard J.L.F. Lemmers (Leiden, Netherlands); Linda Geng (Seattle, Washington); Laura Snider (Seattle, Washington) |
| ABSTRACT | In one aspect, the invention provides a method of screening a human subject to determine if said subject has a genetic predisposition to develop, or is suffering from Facioscapulohumeral Dystrophy (FSHD), said method comprising: (a) providing a biological sample comprising genomic DNA from the subject; and (b) analyzing the portion of the genomic DNA in the sample corresponding to the distal D4Z4-pLAM region on chromosome 4 and determining the presence or absence of a polymorphism resulting in a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/113778 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 1/6897 (20130101) C12Q 2600/156 (20130101) C12Q 2600/172 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2800/2878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198740 | Pollak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Pollak (Brookline, Massachusetts); Elizabeth J. Brown (Dallas, Texas); Johannes Schlondorff (Chestnut Hill, Massachusetts) |
| ABSTRACT | This document features method related to variants in the Inverted Formin 2 (INF2) gene that are associated with susceptibility to focal segmental glomerulosclerosis (FSGS). For example, methods of using such variants for risk assessment and for diagnosing and optimizing treatment of FSGS are provided. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/113957 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6811 (20130101) C12Q 1/6813 (20130101) C12Q 1/6816 (20130101) C12Q 1/6827 (20130101) C12Q 1/6876 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198747 | Velculescu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor E. Velculescu (Dayton, Maryland); Stephen Cristiano (Baltimore, Maryland); Alessandro Leal (Baltimore, Maryland); Jillian A. Phallen (Baltimore, Maryland); Jacob Fiksel (Baltimore, Maryland); Vilmos Adleff (Baltimore, Maryland); Robert B. Scharpf (Baltimore, Maryland) |
| ABSTRACT | This document relates to methods and materials for assessed, monitored, and/or treated mammals (e.g., humans) having cancer. For example, methods and materials for identifying a mammal as having cancer (e.g., a localized cancer) are provided. For example, methods and materials for assessing, monitoring, and/or treating a mammal having cancer are provided. |
| FILED | Friday, May 17, 2019 |
| APPL NO | 17/056726 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1068 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198753 | Mouneimne et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ghassan Mouneimne (Tucson, Arizona); Marco Padilla-Rodriguez (Tucson, Arizona) |
| ABSTRACT | The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to compositions and methods for determining responsiveness to estrogen and estrogen blocking therapies for cancer. |
| FILED | Friday, June 21, 2019 |
| APPL NO | 17/253690 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/10 (20130101) A61K 31/015 (20130101) A61K 31/138 (20130101) A61K 31/4196 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/723 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199543 | FEDOROV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrej G. FEDOROV (Atlanta, Georgia); Mason CHILMONCZYK (Atlanta, Georgia); Peter Arthur KOTTKE (Atlanta, Georgia) |
| ABSTRACT | The present disclosure provides for analysis systems that are configured to extract a fluid sample from a fluid (e.g., aqueous solution) in a reactor (e.g., bioreactor) at a first rate and then flow the fluid sample to a sensor system at a second rate to analyze the fluid sample. The sensor system can detect the presence and/or concentration of molecules (e.g., biomolecules such as biomarkers (e.g., metabolites, proteins, peptides, cytokines, growth factors, DNA, RNA, lipids) and cells of different types and cell properties, e.g., mechanical stiffness, etc.)). The data obtained can be used by a feedback control system to modify, as needed, the conditions in the reactor to enhance the productively of the reactor. |
| FILED | Thursday, August 15, 2019 |
| APPL NO | 17/265914 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 1/2035 (20130101) Original (OR) Class G01N 2001/205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199669 | Sarwal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Minnie M. Sarwal (Portola Valley, California); Tara Sigdel (Palo Alto, California); Amit Kaushal (Mountain View, California); Li Li (Stanford, California); Wenzhong Xiao (San Jose, California); Atul J. Butte (Menlo Park, California); Purvesh Khatri (Menlo Park, California) |
| ABSTRACT | Aspects of the present invention include methods for determining a transplant category of a subject having a transplant. Common mechanisms of rejection injury are uncovered across different tissue transplants, and provide a means to understand rational drug design. Various sources of tissues are examined form the patient for understanding AR mechanism (graft biopsy), as well as monitoring by minimal invasive means (blood) or non-invasive means (urine for the kidney allograft). For biomarker discovery different categories of markers are examined such as genes, proteins, peptides and antibodies. These biomarkers can help determine the subject's transplant category (e.g., acute allograft rejection (AR), stable allograft (STA), BK viremia, BK nephritis, drug toxicity or chronic allograft injury (CAI), and the like). Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods. The methods and compositions find use in a variety of applications. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162093 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199743 | Yap et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pew-Thian Yap (Chapel Hill, North Carolina); Yoonmi Hong (Chapel Hill, North Carolina); Wei-Tang Chang (Chapel Hill, North Carolina) |
| ABSTRACT | A method for accelerating diffusion magnetic resonance imaging (MRI) acquisition via slice interleaved diffusion encoding (SIDE) includes conducting a plurality of simultaneous multislice (SMS) excitations for each of a plurality of SIDE diffusion-weighted volumes to obtain SMS images of an MRI subject at different diffusion orientations, regrouping the images into slice groups with different orientations, generating a plurality of slice-undersampled diffusion weighted volumetric images of the subject, wherein each of the plurality of slice-undersampled diffusion weighted volumetric images is produced by cyclically interleaving the slice groups, such that each slice group is associated with a different diffusion wavevector, and reconstructing a full diffusion-weighted volumetric image of the subject by providing the plurality of slice-undersampled diffusion weighted volumetric images to a neural network trained to produce full diffusion-weighted volumetric versions of diffusion magnetic resonance images from undersampled versions of the diffusion magnetic resonance images. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139426 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4835 (20130101) G01R 33/5608 (20130101) G01R 33/56545 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) G06T 11/006 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199993 | Peli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts); University of Murcia (Murcia, Spain) |
| ASSIGNEE(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Eliezer Peli (Boston, Massachusetts); Fernando Vargas-Martin (Murcia, Spain) |
| ABSTRACT | An implementation of an optical system for expanding the field of view can include a first optical element and a second optical element. The first optical element can include a first surface and a second surface. The first surface can be configured to reflect a first light beam incident on the first surface at a first incident angle greater than a first predetermined angle, and the second surface can be configured to reflect the reflected first light beam towards a location. The second optical element can include a third surface and a fourth surface. The third surface can be configured to reflect a second light beam incident on the third surface at a second incident angle greater than a second predetermined angle, and the fourth surface can be configured to reflect the reflected second light beam towards the location. Related apparatus, systems, techniques and articles are also described. |
| FILED | Thursday, October 11, 2018 |
| APPL NO | 16/754224 |
| CURRENT CPC | Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/086 (20130101) Original (OR) Class G02C 11/10 (20130101) G02C 2202/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210201479 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wensheng Fan (Plano, Texas); John Michael DiMaio (Dallas, Texas); Jeffrey E. Thatcher (Irving, Texas); Peiran Quan (Dallas, Texas); Faliu Yi (Allen, Texas); Kevin Plant (Dallas, Texas); Ronald Baxter (Grand Prairie, Texas); Brian McCall (Dallas, Texas); Zhicun Gao (Plano, Texas); Jason Dwight (Dallas, Texas) |
| ABSTRACT | Machine learning systems and methods are disclosed for prediction of wound healing, such as for diabetic foot ulcers or other wounds, and for assessment implementations such as segmentation of images into wound regions and non-wound regions. Systems for assessing or predicting wound healing can include a light detection element configured to collect light of at least a first wavelength reflected from a tissue region including a wound, and one or more processors configured to generate an image based on a signal from the light detection element having pixels depicting the tissue region, determine reflectance intensity values for at least a subset of the pixels, determine one or more quantitative features of the subset of the plurality of pixels based on the reflectance intensity values, and generate a predicted or assessed healing parameter associated with the wound over a predetermined time interval. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/013336 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/445 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/30088 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210201702 | MALI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Prashant MALI (La Jolla, California); Udit PAREKH (La Jolla, California); Amir DAILAMY (La Jolla, California); Xin LEI (La Jolla, California); Michael HU (La Jolla, California) |
| ABSTRACT | The present disclosure provides information on the methodology used in the fabrication of three-dimensional cellularized tissue constructs from free-standing evacuable 3D printed composites and/or scaffolds embedded in an extracellular matrix mimic generated from biocompatible materials. The purposes of using these composite and/or scaffold materials is to generate complex embedded lumens that allow for complete perfusion of the matrix construct by standard cell culture media, thereby allowing for maintenance of large-scale 3D cell cultures in specific geometric forms. The use of biological extracellular matrix materials is to provide essential biological and mechanical signals needed to regulate the behavior of encapsulated cells. Furthermore, the methodology can be adapted such that the lumens generated are capable of being seeded with various endothelial and epithelial cell types as desired, thereby allowing for mimicry of in vivo vasculature, intestinal tracts, and other lumen-containing constructs. This disclosure provides the methodology for generating the tissue constructs. |
| FILED | Tuesday, May 21, 2019 |
| APPL NO | 17/056724 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 2502/00 (20130101) C12N 2513/00 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) C12N 2533/74 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/306 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210196161 | Plaxco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Kevin Plaxco (Santa Barbara, California); Netzahualcoyotl Arroyo Curras (Baltimore, Maryland) |
| ABSTRACT | Typical electrochemical sensors measure target-induced changes in current output. Such measures of target binding are inconsistent across individual sensors, and furthermore, signal will drift over time when the sensor is deployed for long periods. These shortcomings can be avoided by the novel use of chronoamperometry to measure current decay kinetics as the indicator of target binding. Current decay lifetimes will vary in a concentration dependent manner, but remain stable across individual sensors and over time, allowing for calibration-free operation. By these methods, aptamer based electrochemical sensors and other sensor types may be deployed in vivo for extended periods of time and will provide accurate measurement of target binding without calibration. |
| FILED | Monday, October 29, 2018 |
| APPL NO | 16/756681 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1451 (20130101) A61B 5/4277 (20130101) A61B 5/4866 (20130101) A61B 5/14517 (20130101) A61B 5/14546 (20130101) A61B 5/14735 (20130101) Original (OR) Class A61B 2503/40 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54386 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196227 | Salinas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| INVENTOR(S) | Jose Salinas (San Antonio, Texas); Ronald D. Grisell (Spring Branch, Texas); Sena R. Veazey (San Antonio, Texas); Saul J. Vega (San Antonio, Texas) |
| ABSTRACT | Improved systems and methods for diagnosing an injury of a patient. The system and methods provide for more accurate scans of the injury thereby enabling a combat medic, a medical technician, or even untrained individuals to quickly diagnose the injury. By providing more accurate information, the systems and methods provide the technician with additional information regarding treatment options, such as whether to transport the patient or treat the patient in place, potential for aspiration, and other information about dangerous fluid build-up such as size, depth, and types of surrounding tissues, thereby increasing survivability of the patient. The systems and methods can also provide a diagnosis of the injury as well as suggestions on actions to take to treat the patient. |
| FILED | Wednesday, August 21, 2019 |
| APPL NO | 17/269739 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) Original (OR) Class A61B 8/465 (20130101) A61B 8/469 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0607 (20130101) B06B 2201/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196245 | Berthier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tasso, Inc. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erwin Berthier (Seattle, Washington); Ben Casavant (Seattle, Washington); Jake Myre (Seattle, Washington) |
| ABSTRACT | Devices and methods for withdrawing bodily fluid from a patient are disclosed herein. A handheld device configured in accordance with the present technology can include a housing having an opening, a skin-piercing assembly located at least partially within the housing, and an actuator movable relative to the housing along a deployment direction. The skin-piercing assembly can include a skin-piercing feature and a biasing member. The biasing member can be coupled to the skin-piercing feature to bias the skin-piercing feature along the deployment direction. Movement of the actuator along the deployment direction to a predetermined position can increase a load on the biasing member to at least a partially loaded state. Movement of the actuator along the deployment direction beyond the predetermined position can release the load on the biasing member so that the biasing member actively drives the skin-piercing feature along the deployment direction. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186369 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/15117 (20130101) A61B 5/150053 (20130101) A61B 5/150221 (20130101) A61B 5/150374 (20130101) A61B 10/0045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196797 | Wagner |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Amy Kathleen Wagner (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure relates to methods, compositions, and kits for treating traumatic brain injury (TBI) and TBI-associated impairments in a subject. The methods include administering to the subject an interleukin-7 (IL-7) or IL-7 agonist, a TNFα inhibitor, or both. The present disclosure also relates to methods of using biomarkers for identifying a subject that is likely to respond to a treatment for TBI-associated impairments, and monitoring the subject's response to such treatment. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135970 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2046 (20130101) Original (OR) Class Peptides C07K 16/241 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/70578 (20130101) G01N 2800/28 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210197194 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178824 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 2400/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210197498 | SAHIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Ozgur SAHIN (New York, New York); Eran SCHENKER (New York, New York); Yocheved UNGAR (New York, New York); Onur CAKMAK (Mineola, New York) |
| ABSTRACT | Systems and methods for developing a composite material are disclosed. The system can include a plurality of particles and a plurality of filaments. The plurality of particles can generate mechanical force in response to changing relative humidity, and the plurality of filaments can transfer the mechanical force throughout the composite material. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/187135 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/025 (20130101) Original (OR) Class B29C 70/88 (20130101) B29C 70/305 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198288 | BURNS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VenatoRx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. BURNS (Malvern, Pennsylvania); Denis DAIGLE (Street, Maryland); Guo-Hua CHU (Exton, Pennsylvania); Jodie HAMRICK (New Holland, Pennsylvania); Steven A. BOYD (Chester Springs, Pennsylvania); Allison L. ZULLI (Chesterbrook, Pennsylvania); Eugen F. MESAROS (Wallingford, Pennsylvania); Stephen M. CONDON (Glenmoore, Pennsylvania); Robert E. Lee TROUT (Collegeville, Pennsylvania); Cullen L. MYERS (Exton, Pennsylvania); Zhenrong XU (Chalfont, Pennsylvania) |
| ABSTRACT | Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057593 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198330 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Luke W. Koblan (Cambridge, Massachusetts); Christopher Gerard Wilson (Cambridge, Massachusetts); Jordan Leigh Doman (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. The disclosure provides fusion proteins of nucleic acid programmable DNA binding proteins (napDNAbp), e.g., Cas9 or variants thereof, and nucleic acid editing proteins such as cytidine deaminase domains (e.g., novel cytidine deaminases generated by ancestral sequence reconstruction), and adenosine deaminases that deaminate adenine in DNA. Aspects of the disclosure relate to fusion proteins (e.g., base editors) that have improved expression and/or localize efficiently to the nucleus. In some embodiments, base editors are codon optimized for expression in mammalian cells. In some embodiments, base editors include multiple nuclear localization sequences (e.g., bipartite NLSs), e.g., at least two NLSs. In some embodiments, methods for targeted nucleic acid editing are provided. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057398 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) Original (OR) Class C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) Enzymes C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198427 | McLeod et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David C. McLeod (Abingdon, Maryland); Robert H. Lambeth, III (Elkton, Maryland); Kevin R. Waters (Baltimore, Maryland); Emil J. Sandoz-Rosado (Baltimore, Maryland); Eric D. Wetzel (Bel Air, Maryland) |
| ABSTRACT | Two-dimensional (2D) polymers and methods for their formation are described herein. To create oriented 2D polymer films, monomers are combined with processing additives within a solvent, creating a solution that can be cast and dried to remove the solvent and form a solid film. The methods can enable transformation of the monomers into oriented films. Film quality can be controlled via multiple processing parameters, including monomer and additive concentrations, shear and elongational flow rates during casting, evaporation rates, and post-process rinsing, buffering, stretching, and thermal treatments. By combining stiff carbon-containing cyclic polymer nodal units with more compliant linear polymer bridge units in an ordered, 2D repeating molecular structure it is possible to tailor the mechanical properties of 2D polymers and their assemblies to provide high stiffness, strength, and toughness. The 2D polymer can also be combined with other 2D materials, linear polymers, or reinforcing materials to create 2D polymer composites. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195263 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/00 (20130101) C08G 63/065 (20130101) C08G 63/78 (20130101) C08G 63/127 (20130101) C08G 63/133 (20130101) C08G 69/32 (20130101) C08G 73/18 (20130101) C08G 73/22 (20130101) C08G 73/028 (20130101) C08G 73/1067 (20130101) Original (OR) Class C08G 75/32 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198607 | WIKSWO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. WIKSWO (Brentwood, Tennessee); Eric C. SPIVEY (Nashville, Tennessee); David K. SCHAFFER (Nashville, Tennessee); Ronald S. REISERER (Nashville, Tennessee); Kevin T. SEALE (Nashville, Tennessee); Frank E. BLOCK, III (Potomac, Maryland) |
| ABSTRACT | One aspect of the invention provides a multichamber bioreactor. The multichamber bioreactor includes multiple planar layers stacked on each other defining at least one chamber and a clamping mechanism. The clamping mechanism includes a housing and retaining means received in the housing and configured to generate a controlled and uniform pressure to secure the stacked multiple planar layers in the housing. Each chamber is implemented from a separate fluidic layer, with each fluidic layer having ports and valves independent of the other layers. The micro fluidic ports can be actuated through a micro fluidic interconnect system utilizing rotary cylinder valves. |
| FILED | Wednesday, May 29, 2019 |
| APPL NO | 17/057267 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0247 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502715 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/44 (20130101) C12M 23/58 (20130101) C12M 29/00 (20130101) C12M 41/48 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/0045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198669 | HEIER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's National Medical Center (Washington, District of Columbia) |
| ASSIGNEE(S) | Children's National Medical Center (Washington, District of Columbia) |
| INVENTOR(S) | Christopher HEIER (Washington, District of Columbia); Alyson FIORILLO (Washington, District of Columbia) |
| ABSTRACT | The present disclosure relates to compositions comprising an antisense RNA sequence comprising a region of complementarity that is substantially complementary to an miRNA. Pharmaceutical compositions comprising the antisense RNA molecule, optionally further comprising an anti-inflammatory corticosteroid are also disclosed. Methods of treating or preventing inflammation, a steroid side effect, or a muscle disease using the one or the pharmaceutical compositions are also disclosed. |
| FILED | Monday, June 03, 2019 |
| APPL NO | 17/059700 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2320/31 (20130101) C12N 2320/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198688 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts) |
| ABSTRACT | Disclosed are methods and constructs for engineering circular RNA. Disclosed is a vector for making circular RNA, said vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, said vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. In another embodiment, the vector can comprise the 5′ spacer sequence, but not the 3′ spacer sequence. In yet another embodiment, the vector can comprise the 3′ spacer sequence, but not the 5′ spacer sequence. Also disclosed is a method for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191697 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198714 | Pirmoradi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatemeh Nazly Pirmoradi (Menlo Park, California); Gregory Whiting (Menlo Park, California) |
| ABSTRACT | A method comprises printing a conductive ink on a substrate to form one or more electrodes and printing an electrode ink on one or more of the electrodes. The conductive and electrode inks are cured. Next, an enzyme ink layer is printed on at least one electrode, and the enzyme ink layer is cured with ultraviolet light. Each of the printing and curing processes are performed in an in-line process. |
| FILED | Tuesday, December 31, 2019 |
| APPL NO | 16/731323 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/08 (20130101) C12N 13/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198726 | McFarland et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirsty A. McFarland (Melrose, Massachusetts); Andrew P. Magyar (Arlington, Massachusetts); Ting Pang (Cambridge, Massachusetts); Michael Springer (Brookline, Massachusetts) |
| ABSTRACT | Methods of detecting unknown genetic modifications in a DNA sample from an organism are disclosed. |
| FILED | Friday, October 12, 2018 |
| APPL NO | 16/755710 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198817 | Göktepe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Özer Göktepe (Istanbul, Turkey); Fatma Göktepe (Istanbul, Turkey); Na Li (Dallas, Texas); Shaoli Fang (Richardson, Texas); Ray H. Baughman (Dallas, Texas); Marcio Dias Lima (Richardson, Texas); Carter S. Haines (Murphy, Texas) |
| ABSTRACT | A smart (intelligent) textile that can control its porosity, shape, texture, loft, stiffness, or color by temperature change or moisture absorption by using polymer fiber torsional and tensile actuators. This temperature change can be due to a change in ambient temperature or by an external stimulus, such as electrothermal heating. Mechanisms to accomplish this include (a) direct actuation (contraction or expansion) of polymer fiber actuators in a textile structure (b) rotation of polymer fiber actuators helically wrapped around warp and/or weft yarns in a textile structure; (c) rotation of chenille type or ribbon-like warp (or weft) ends by polymer fiber torsional actuators; (d) contraction or expansion of piles or loops in a chenille type fancy yarn produced by using mandrel actuators as pile or loop part of the yarn; (e) buckling of warp (or weft) yarns by contraction of tensile polymer fiber actuators; (f) decrease in yarn diameter by a twisting effect of polymer fiber actuators; (g) contraction or expansion of segmented mandrel actuators with core filament, wire or yarns; or (h) rotation of differentially dyed polymer fiber actuators for color changing textiles. |
| FILED | Tuesday, March 21, 2017 |
| APPL NO | 16/087540 |
| CURRENT CPC | Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/26 (20130101) Original (OR) Class Woven Fabrics; Methods of Weaving; Looms D03D 15/567 (20210101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2401/02 (20130101) D10B 2401/046 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199408 | Reed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | Dean Reed (Titusville, Florida); Devyn Dodge (Orlando, Florida); Troyle Thomas (Winter Springs, Florida) |
| ABSTRACT | A device can include one or more sensors configured to output sensor data, and a trigger detection module configured to receive the sensor data from the one or more sensors and to determine whether a trigger event has occurred. The trigger detection module can be configured to output a trigger detection signal when the trigger event is detected. The trigger detection signal can be configured to be used by an augmented reality or virtual reality system to cause an augmented reality or virtual reality event. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/137287 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 33/02 (20130101) Weapon Sights; Aiming F41G 3/32 (20130101) F41G 3/2633 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 19/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199651 | ZENHAUSERN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederic ZENHAUSERN (Chandler, Arizona); Peng CHEN (Chandler, Arizona); Jian GU (Chandler, Arizona); Jerome LACOMBE (Chandler, Arizona) |
| ABSTRACT | Provided are vertical flow detection devices and related methods. The devices may comprise a membrane having a first surface and a second surface with a plurality of porous structures extending between the first and second surfaces to form fluid conduits from a first fluid chamber formed by the first surface and a second fluid chamber formed by the second fluid surface. A capture agent is immobilized on and/or in the membrane. A rigid porous membrane support mechanically supports the membrane and to provide a relatively uniform flow across the membrane. Various gaskets or holder elements are positioned around an outer edge of the membrane to prevent fluid leakage around the membrane. A fluid pump is configured to force a fluid sample flow in a direction from the first fluid chamber to the second fluid chamber. |
| FILED | Friday, March 29, 2019 |
| APPL NO | 17/040417 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2300/0877 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54386 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199815 | Kassas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zak M. Kassas (Riverside, California); Joe Khalife (Riverside, California); Kimia Shamaei (Riverside, California) |
| ABSTRACT | A GNSS augmented using signals of opportunity (SOPs) provides various technical solutions to technical problems facing GNSS implementations. SOPs may enhance or enable otherwise unavailable navigation, such as whenever GNSS signals become inaccessible or untrustworthy, Terrestrial SOPs are abundant and are available at varying geometric configurations, and may be used to improve GNSS by reducing VDOP, VDOP may be reduced by exploiting existing terrestrial SOPs, particularly cellular code division multiple access (CDMA) signals, which have inherently low elevation angles and are free to use. |
| FILED | Friday, February 10, 2017 |
| APPL NO | 16/077404 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/46 (20130101) Original (OR) Class G01S 19/51 (20130101) G01S 19/396 (20190801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210201121 | Fink et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Yoel Fink (Brookline, Massachusetts); Gabriel Zi Jie Loke (Cambridge, Massachusetts); Tural Khudiyev (Revere, Massachusetts) |
| ABSTRACT | A fiber computer has a fiber body including electrically insulating fiber body material along the length of the fiber body. Electrical conductors are disposed within the fiber body and are operative to transmit electrical power, electrical ground, clock signals, and data signals through the fiber body. Input units disposed within the fiber body accept external stimuli. Microcontroller microchips disposed within the fiber body process stimuli accepted by an input unit. Memory module microchips within the fiber body store data and communicate with microcontroller microchips. Output units produce an output directed out of the fiber body. A clock signal generator within the fiber body synchronizes operation of input units, microcontroller microchips, memory module microchips, and output units. Each of the computer input units, microcontroller microchips, memory module microchips, and computer output units are disposed in electrical connection with the plurality of electrical conductors for fiber computer operation within the fiber body. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/086154 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/063 (20130101) Original (OR) Class Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) H01B 3/30 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/08 (20130101) H04R 1/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210201479 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wensheng Fan (Plano, Texas); John Michael DiMaio (Dallas, Texas); Jeffrey E. Thatcher (Irving, Texas); Peiran Quan (Dallas, Texas); Faliu Yi (Allen, Texas); Kevin Plant (Dallas, Texas); Ronald Baxter (Grand Prairie, Texas); Brian McCall (Dallas, Texas); Zhicun Gao (Plano, Texas); Jason Dwight (Dallas, Texas) |
| ABSTRACT | Machine learning systems and methods are disclosed for prediction of wound healing, such as for diabetic foot ulcers or other wounds, and for assessment implementations such as segmentation of images into wound regions and non-wound regions. Systems for assessing or predicting wound healing can include a light detection element configured to collect light of at least a first wavelength reflected from a tissue region including a wound, and one or more processors configured to generate an image based on a signal from the light detection element having pixels depicting the tissue region, determine reflectance intensity values for at least a subset of the pixels, determine one or more quantitative features of the subset of the plurality of pixels based on the reflectance intensity values, and generate a predicted or assessed healing parameter associated with the wound over a predetermined time interval. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/013336 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/445 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/30088 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202029 | Atallah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle Atallah (Stanford, California); Parag Mallick (Stanford, California) |
| ABSTRACT | A software model for directed graph representation of the intercellular immune interaction network which can be used to extract mechanistic insight from immune data in order to predict the outcome of immune system perturbations, identify effective drug targets, stratify patients, and inform therapeutic selection. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/132752 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202141 | Familiant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Eaton Intelligent Power Limited (Dublin, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yakov L. Familiant (Thiensville, Wisconsin); Paul J. Rollmann (Menomonee Falls, Wisconsin); Andrew A. Rockhill (Waukesha, Wisconsin) |
| ABSTRACT | An apparatus includes a laminated bus bar assembly with first and second bus bars and an intervening insulator layer. A surge arrestor (e.g., a metal oxide varistor) has a body mounted on the bus bar assembly and first and second terminals on first and second opposite sides of the body. In some embodiments, the body may be at least partially disposed in an opening in the first bus bar and the second terminal may be conductively bonded to a surface of the second bus bar that faces the insulator layer. In some embodiments, the second terminal may include a conductive stud passing through an opening in the second bus bar. The apparatus may include a spring clamp attached to the first bus bar and contacting the first side of the body to retain the body. |
| FILED | Monday, August 10, 2020 |
| APPL NO | 16/989531 |
| CURRENT CPC | Resistors H01C 7/12 (20130101) Original (OR) Class Installation of Electric Cables or Lines, or of Combined Optical and Electric Cables or Lines H02G 5/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202870 | Yoon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Young Jun Yoon (Atlanta, Georgia); Zhiqun Lin (Atlanta, Georgia); Zhitao Kang (Atlanta, Georgia); Brent Wagner (Atlanta, Georgia); Jonathan Christopherv James (Atlanta, Georgia) |
| ABSTRACT | The disclosed technology includes an infrared-emitting quantum dot comprising a core comprising a first semiconductor material, a shell comprising a second semiconductor material, and a gradient interface between the core and the shell. The disclosed technology also includes methods of manufacturing the same. |
| FILED | Wednesday, August 21, 2019 |
| APPL NO | 17/267103 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/56 (20130101) C09K 11/661 (20130101) C09K 11/883 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/502 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202936 | Oh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyukkeun Oh (Boulder, Colorado); Se-Hee Lee (Superior, Colorado); Joshua Buettner-Garrett (Arvada, Colorado) |
| ABSTRACT | A solid-state battery includes an anode material including silicon or tin. The anode material may include silicon and/or tin in various forms including layers or intermixed particles of various phases and crystallinity. |
| FILED | Tuesday, October 16, 2018 |
| APPL NO | 16/756686 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) H01M 4/382 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/387 (20130101) H01M 10/0562 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202943 | Tour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | James M. Tour (Bellaire, Texas); Rodrigo Villegas Salvatierra (Houston, Texas); Gladys Anahi Lopez Silva (Houston, Texas); Abdul-Ramahn O. Raji (Houston, Texas) |
| ABSTRACT | Alkali metal-sulfur cells and batteries with cathode layers that store alkali metal charge carriers (e.g., lithium ions) in agglomerates of sulfurized carbon. The cathode layers lack costly and environmentally unfriendly nickel and cobalt. The cathode layers are composites that include agglomerates of sulfurized-carbon particles in a conductive binder and interconnected by sp2-bonded carbon materials, such as carbon nanotubes or nanoribbons, that extend within the agglomerates and between the sulfurized-carbon particles. |
| FILED | Tuesday, September 01, 2020 |
| APPL NO | 17/009530 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/583 (20130101) Original (OR) Class H01M 4/623 (20130101) H01M 4/667 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202964 | Junaedi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRECISION COMBUSTION, INC. (North Haven, Connecticut) |
| ASSIGNEE(S) | PRECISION COMBUSTION, INC. (, None) |
| INVENTOR(S) | Christian Junaedi (Cheshire, Connecticut); Subir Roychoudhury (Madison, Connecticut); Kyle Hawley (Woodbury, Connecticut); Saurabh Vilekar (Woodbridge, Connecticut) |
| ABSTRACT | An individual solid oxide cell (SOC) constructed of a sandwich configuration including in the following order: an oxygen electrode, a solid oxide electrolyte, a fuel electrode, a fuel manifold, and at least one layer of mesh. In one embodiment, the mesh supports a reforming catalyst resulting in a solid oxide fuel cell (SOFC) having a reformer embedded therein. The reformer-modified SOFC functions internally to steam reform or partially oxidize a gaseous hydrocarbon, e.g. methane, to a gaseous reformate of hydrogen and carbon monoxide, which is converted in the SOC to water, carbon dioxide, or a mixture thereof, and an electrical current. In another embodiment, an electrical insulator is disposed between the fuel manifold and the mesh resulting in a solid oxide electrolysis cell (SOEC), which functions to electrolyze water and/or carbon dioxide. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193054 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/00 (20130101) C25B 1/04 (20130101) C25B 9/19 (20210101) C25B 9/70 (20210101) C25B 9/77 (20210101) C25B 11/00 (20130101) C25B 15/02 (20130101) C25B 15/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/12 (20130101) H01M 8/184 (20130101) H01M 8/0258 (20130101) H01M 8/0625 (20130101) H01M 8/0631 (20130101) H01M 8/2425 (20130101) H01M 8/2483 (20160201) H01M 8/04037 (20130101) Original (OR) Class H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210203049 | RINALDI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matteo RINALDI (Boston, Massachusetts); Giuseppe MICHETTI (Somerville, Massachusetts) |
| ABSTRACT | Adaptive RF filters based on modulated resonators are provided. The filter architecture is based on time-interleaved commutation of passive RF resonators. The architecture can behave as a two-port filter network, with a fully tunable instantaneous filter bandwidth. The filters are applicable as miniaturized, environment-aware RF signal processing components and can be used in mobile communications. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/131964 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/2053 (20130101) Original (OR) Class H01P 7/06 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/542 (20130101) Transmission H04B 1/7093 (20130101) H04B 2001/70935 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210203085 | Jordan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cubic Corporation (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared W Jordan (Raleigh, North Carolina); Kenneth J Vanhille (Cary, North Carolina); Timothy A Smith (Durham, North Carolina); William Stacy (Blacksburg, Virginia); Benjamin L Cannon (Apex, North Carolina); David W Sherrer (Cary, North Carolina) |
| ABSTRACT | Antenna arrays, including a broadband single or dual polarized, tightly coupled radiator arrays. |
| FILED | Tuesday, June 19, 2018 |
| APPL NO | 16/076354 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/40 (20130101) H01Q 9/065 (20130101) H01Q 13/085 (20130101) H01Q 21/24 (20130101) H01Q 21/062 (20130101) H01Q 21/064 (20130101) H01Q 21/0093 (20130101) H01Q 25/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210203385 | Lanham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | S. Andrew Lanham (Austin, Texas); Travis Cuvelier (Austin, Texas); Brian R. La Cour (Austin, Texas); Robert Heath, Jr. (Raleigh, North Carolina) |
| ABSTRACT | A disclosed transmitter for wireless communication includes multiple transmitting antennas, a symbol mapper for mapping an input block including multiple binary bits and representing information to be transmitted to a symbol representing an ordered plurality of complex numbers, a space-time encoder for applying an encoding operator to the symbol to produce a vectorized space-time codeword defining electrical signals to be transmitted by the transmitter, the encoding operator being dependent on a set of predefined stabilizer generators, and circuitry to collectively transmit, by the antennas to multiple receiving antennas of a receiver over a wireless transmission channel, the electrical signals defined by the vectorized space-time codeword. The receiver includes a space-time decoder for recovering the symbol from the electrical signals transmitted by the transmitter using a decoding operation that is based on maximum likelihood inference, and a symbol de-mapper for recovering the input block from the symbol. |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/124019 |
| CURRENT CPC | Transmission H04B 7/0413 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0014 (20130101) Wireless Communication Networks H04W 72/046 (20130101) H04W 72/0466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210203886 | Byrne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Systems and Technology Research, LLC (Woburn, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Byrne (Lexington, Massachusetts); Brian DeCann (Boston, Massachusetts); Scott Harris Bloom (Encinitas, California) |
| ABSTRACT | A system for inferring features in a digital image includes a vision sensor for capturing and optically encrypting an image of a visual scene so as to shroud any human-perceivable features contained therein. An image interpreter in communication with the vision sensor is programmed to recognize and classify features in the encrypted image without prior decryption, thereby ensuring the privacy of any subjects depicted therein. The vision sensor is encoded with a calibration key that applies a unique transformation function to optically encrypt the captured image. The image interpreter is permitted access to the calibration key and applies a convolutional network constructed using the calibration key, a source convolutional network, and a set of private layer keys in order to infer features in the encrypted image without prior decryption. For applications requiring enhanced privacy protection, the inference output produced by the image interpreter remains encrypted but available for further feature detection. |
| FILED | Saturday, November 28, 2020 |
| APPL NO | 17/106077 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Image Data Processing or Generation, in General G06T 5/40 (20130101) Pictorial Communication, e.g Television H04N 7/183 (20130101) H04N 7/1675 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210204122 | Pratt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| INVENTOR(S) | Thomas G. Pratt (South Bend, Indiana); Joseph Lawrence Loof (South Bend, Indiana); Eric Jesse (South Bend, Indiana) |
| ABSTRACT | Devices and techniques for authenticating wireless communications are disclosed. In some embodiments, the techniques can be performed by a network access point that includes a receiver to receive a wireless signal from a remote device. The network access point can also include a processor to calculate polarization data for the wireless signal and to determine whether the polarization data includes at least one characteristic that corresponds to a characteristic of a stored authenticated polarization signature. |
| FILED | Wednesday, June 19, 2019 |
| APPL NO | 17/126762 |
| CURRENT CPC | Transmission H04B 7/10 (20130101) Wireless Communication Networks H04W 12/06 (20130101) Original (OR) Class H04W 12/79 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210204388 | McDonald |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael McDonald (Washington, District of Columbia) |
| ABSTRACT | Methods and apparatuses for emitting electrons from a hollow cathode are provided. The cathode includes a plasma holding region configured to hold a plasma, a gas supply source configured to supply gas to the plasma holding region, and an orifice plate disposed on a periphery of the plasma holding region. The orifice plate comprises a plurality of openings constructed to receive electrons from the plasma. The plurality of openings decouple gas conductance and electrical conductance across the orifice plate. The diameters of the plurality of openings are within a range of 20%-60%, inclusive, of a diameter of a circular opening with an area equal to a sum of the areas of the plurality of openings. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/183328 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/48 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210197099 | Peterson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rick Peterson (Columbus, Ohio); Steven M. Risser (Reynoldsburg, Ohio) |
| ABSTRACT | Disclosed are methods of separating solute from solvent using a photoactive extractant. The photoactive extractant can be switched between two states by exposure to light. This can change the affinity of the photoactive extractant for either the solute or the solvent, causing absorption of the solute or solvent. The photoactive extractant can then be separated from the fluid stream containing the solute or solvent. The absorbed solute or solvent is then separated from the photoactive extractant. The photoactive extractant is a photoisomer. Applications for these methods include desalination, water purification, and metal extraction. |
| FILED | Friday, May 31, 2019 |
| APPL NO | 17/057388 |
| CURRENT CPC | Separation B01D 11/0492 (20130101) Original (OR) Class Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/30 (20130101) C02F 1/265 (20130101) C02F 2103/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210197172 | GOEPPERT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alain GOEPPERT (Los Angeles, California); Hang ZHANG (Los Angeles, California); George A. OLAH (Los Angeles, California); G.K. Surya PRAKASH (Los Angeles, None) |
| ABSTRACT | The invention relates to regenerative, solid sorbents for adsorbing carbon dioxide from a gas mixture, including air, with the sorbent including a modified polyamine and a solid support. The modified polyamine is the reaction product of an amine and an epoxide. The sorbent provides structural integrity, as well as high selectivity and increased capacity for efficiently capturing carbon dioxide from gas mixtures, including the air. The sorbent is regenerative, and can be used through multiple cycles of adsorption-desorption. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/199252 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 53/04 (20130101) B01D 2253/25 (20130101) B01D 2253/202 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) Original (OR) Class B01J 20/262 (20130101) B01J 20/3078 (20130101) B01J 20/3204 (20130101) B01J 20/3231 (20130101) B01J 20/3272 (20130101) B01J 20/3425 (20130101) B01J 20/3483 (20130101) B01J 20/3491 (20130101) B01J 20/28007 (20130101) Acyclic or Carbocyclic Compounds C07C 29/48 (20130101) C07C 41/01 (20130101) C07C 51/16 (20130101) Capture, Storage, Sequestration or Disposal of Greenhouse Gases [GHG] Y02C 20/40 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210197194 | Schaffer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178824 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 2400/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210197241 | Grant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (, None) |
| INVENTOR(S) | Glenn J. Grant (Benton City, Washington); Keerti S. Kappagantula (Richland, Washington); Xiao Li (Richland, Washington) |
| ABSTRACT | Shear assisted extrusion processes (ShAPE) for forming Metal-NCCF extrusions are provided. The processes can include: using a die tool, applying a rotational shearing force and an axial extrusion force to a feedstock material comprising a metal and NCCF (NanoCrystalline Carbon Films); and extruding a mixture comprising the metal and NCCF through an opening in the die tool to form the Metal-NCCF extrusion. ShAPE feedstock materials are provided that can include a metal and NCCF. Conductive solid material mixtures are provided that can include a metal and a NCCF. Portions of the metals and NCCF of the material mixtures can have an isotropic crystallographic orientation. Assemblies relying in part on conductivity can include: a conductive solid material mixture that includes: a metal; and a NCCF. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/035597 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/002 (20130101) Original (OR) Class B21C 23/04 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 20/1255 (20130101) B23K 2103/20 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210197691 | STEFANOPOULOU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Anna G. STEFANOPOULOU (Ann Arbor, Michigan); Nassim ABDUL SAMAD (Ann Arbor, Michigan); Youngki KIM (Ann Arbor, Michigan); Jason B. SIEGEL (Ann Arbor, Michigan) |
| ABSTRACT | There is disclosed an electrical device including a battery, and a battery management system. The battery management system includes a controller in electrical communication with a pressure sensor to monitor the state of health of the battery. The controller applies a method for determining the state of health that uses a non-electrical (mechanical) signal of force measurements combined with incremental capacity analysis to estimate the capacity fading and other health indicators of the battery with better precision than existing methods. The pressure sensor may provide the force measurement signal to the controller, which may determine which incremental capacity curve based on force to use for the particular battery. The controller then executes a program utilizing the data from the pressure sensor and the stored incremental capacity curves based on force to estimate the capacity fading and signal a user with the state of health percentage. |
| FILED | Friday, November 18, 2016 |
| APPL NO | 15/777384 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/64 (20190201) B60L 58/16 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198117 | DURHAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessica L. DURHAM (Braidwood, Illinois); Albert L. LIPSON (Oak Park, Illinois); Ozgenur KAHVECIOGLU (Naperville, Illinois) |
| ABSTRACT | A process for preparing doped-lithium lanthanum zirconium oxide (doped-LLZO) is described herein. The method involves dry doping of a co-precipitated lanthanum zirconium oxide (LZO) precursor. Dry doping is a process in which a dry powdered dopant is ground and mixed with a pre-prepared co-precipitated LZO precursor and a lithium salt to provide a LLZO precursor composition, which is subsequently calcined to form a doped-LLZO. The process described herein comprises calcining a dry, powdered (e.g., micron, sub-micron or nano-powdered) mixture of a co-precipitated LZO precursor, a dopant salt or oxide, and a lithium salt under an oxygen-containing atmosphere at a temperature in the range of about 500 to about 1100° C., and recovering the doped-LLZO after calcining. |
| FILED | Thursday, December 26, 2019 |
| APPL NO | 16/727191 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/02 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/70 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 2300/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198708 | Gladden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M. Gladden (Alameda, California); Tanmoy Dutta (Berkeley, California); Jian Sun (Albany, California); Seema Singh (Clarksburg, Maryland); Blake A. Simmons (San Francisco, California) |
| ABSTRACT | Disclosed herein are methods for preparing sugar compositions. The methods include: i) forming a mixture including polysaccharide biomass and an ionic liquid solution, wherein the ionic liquid solution contains water and an ionic liquid, and the ionic liquid contains a) a cation and b) a sugar acid anion or a ketoacid anion; ii) maintaining the mixture under conditions sufficient to dissolve at least a portion of the polysaccharide present in the polysaccharide biomass; iii) adding at least one glycoside hydrolase to the mixture; and iv) maintaining the mixture containing the glycoside hydrolase under conditions sufficient to hydrolyze at least a portion of the dissolved polysaccharide, thereby forming the sugar compositions. The sugar compositions contain at least one monosaccharide or oligosaccharide. New sugar-based ionic liquids are also described. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/190050 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 3/02 (20130101) C07H 3/06 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) C12P 19/14 (20130101) Original (OR) Class C12P 2201/00 (20130101) Enzymes C12Y 302/01021 (20130101) C12Y 302/01032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198816 | Naskar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit K. Naskar (Knoxville, Tennessee); Connie D. Jackson (Harriman, Tennessee) |
| ABSTRACT | A method of producing carbon fibers includes the step of providing polyacrylonitrile precursor polymer fiber filaments. The polyacrylonitrile precursor filaments include from 87-97 mole % acrylonitrile, and less than 0.5 mole % of accelerant functional groups. The filaments are no more than 3 deniers per filament. The polyacrylonitrile precursor fiber filaments can be arranged into tows of at least 150,000 deniers per inch width. The arranged polyacrylonitrile precursor fiber tows are stabilized by heating the tows in at least one oxidation zone containing oxygen gas and maintained at a first temperature T1 while stretching the tows at least 10% to yield a stabilized precursor fiber tow. The stabilized precursor fiber tows are carbonized by passing the stabilized precursor fiber tows through a carbonization zone. Carbon fibers produced by the process are also disclosed. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196964 |
| CURRENT CPC | Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/225 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198923 | Ancheta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dione Ancheta (Livermore, California); Raymond A. Swan (Livermore, California) |
| ABSTRACT | A lockout padlock controls access to a hazardous energy source control box. The control box has a box body and a door that closes the box body. The door has an aperture. A staple is connected to the box body and the staple extends through the aperture in the door of the control box. A first lockout hinge part has a first lockout hinge part padlock hole. A second lockout hinge part has a second lockout hinge part padlock hole. The first lockout hinge part and the second lockout hinge part are position together to form a padlock pocket. A first padlock is positioned and locked in the staple. The first padlock is positioned in said padlock pocket and covered by said first lockout hinge part and said second lockout hinge part. A second padlock is positioned in the first lockout hinge part padlock hole and in said second lockout hinge part padlock hole. |
| FILED | Thursday, December 26, 2019 |
| APPL NO | 16/727555 |
| CURRENT CPC | Locks; Accessories Therefor; Handcuffs E05B 67/383 (20130101) Original (OR) Class Displaying; Advertising; Signs; Labels or Name-plates; Seals G09F 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199298 | Berry |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Dwight Berry (Simpsonville, South Carolina) |
| ABSTRACT | A combustor may include a combustor liner and flow sleeve. A high pressure air cools an outer surface of the combustor liner via openings in the flow sleeve, creating a lower pressure air in an annulus between the combustor liner and the flow sleeve. A first fuel nozzle is positioned at a primary combustion zone, and a second fuel nozzle is positioned at a secondary combustion zone of the liner. A fuel source is configured to deliver a fuel to the fuel nozzles. The fuel nozzles produce a premixture of high pressure air and the fuel, and produce a mixture of the premixture and the lower pressure air, prior to introducing the mixture to a respective primary or secondary combustion zone of the combustor. The combustor provides improved fuel premixing and is fuel flexible, and reduces pressure drop requirements. The combustor is usable in a can, annular, or segmented annular combustor assembly. |
| FILED | Tuesday, December 31, 2019 |
| APPL NO | 16/731207 |
| CURRENT CPC | Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/005 (20130101) F23R 3/10 (20130101) F23R 3/26 (20130101) F23R 3/36 (20130101) F23R 3/286 (20130101) Original (OR) Class F23R 3/346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199299 | Berry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | General Electric Company (Schenectady, New York) |
| INVENTOR(S) | Jonathan Dwight Berry (Simpsonville, South Carolina); Wei Zhao (Greenville, South Carolina); Michael John Hughes (State College, Pennsylvania) |
| ABSTRACT | A fluid mixing apparatus includes mixing conduits that extend through a fluid plenum and that define injection holes therethrough. The fluid plenum, which surrounds a first wall defining a main passage fluidly coupled to a low-pressure fluid source, is surrounded itself by a second wall defining a high-pressure plenum fluidly coupled to a high-pressure fluid source. The mixing conduits fluidly couple the high-pressure plenum to the main passage, and the fluid from the fluid plenum is delivered with the high-pressure fluid to the main passage, where the fluids mix before being discharged from an outlet of the main passage. The fluid mixing apparatus may be used to mix one or more fuels with high- and low-pressure air in a gas turbine combustor. Alternately, the fluid mixing apparatus may mix a fluid with high- and low-pressure water streams. |
| FILED | Tuesday, December 31, 2019 |
| APPL NO | 16/731283 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 3/0865 (20130101) B01F 3/04049 (20130101) B01F 5/0486 (20130101) B01F 2215/008 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199300 | Berry |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | General Electric Company (Schenectady, New York) |
| INVENTOR(S) | Jonathan Dwight Berry (Simpsonville, South Carolina) |
| ABSTRACT | A fluid mixing apparatus includes mixing conduits that extend through a fluid plenum. The fluid plenum, which surrounds a first wall defining a main passage fluidly coupled to a low-pressure fluid source, is surrounded itself by a second wall defining a high-pressure plenum fluidly coupled to a high-pressure fluid source. An insulated tube disposed at the inlet of the first wall delivers a third fluid. The mixing conduits fluidly couple the high-pressure plenum to the main passage, where the high-pressure fluid is mixed with low-pressure fluid and the third fluid. Optionally, the fluid plenum may house a fourth fluid that is injected through injection holes in the mixing conduits. The fluid mixing apparatus may be used to mix one or more fuels with high- and low-pressure air in a gas turbine combustor. Alternately, the fluid mixing apparatus may mix a fluid with high- and low-pressure water streams. |
| FILED | Tuesday, December 31, 2019 |
| APPL NO | 16/731306 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/22 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199316 | Poerschke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RHEIA, LLC. (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Poerschke (Pittsburgh, Pennsylvania); Anthony Grisolia (West Leechburg, Pennsylvania); Robert Beach (Pittsburgh, Pennsylvania) |
| ABSTRACT | An indoor environmental control and air distribution system for a building includes: an air handling unit; a manifold connected to the air handling unit having a chamber formed by a plurality of walls and a plurality of orifices formed through at least one of the walls; air distribution conduits each independently having a first end connected to the orifices of the manifold and a second end extending out from the manifold into different zones throughout the building; and an airflow modulating device having one or more airflow regulating dampers independently configured to move into at least two positions in which each position provides a different percentage of total air volume to each air distribution conduit. A method of using the indoor environmental control and air distribution system is also included. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198797 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 3/044 (20130101) Original (OR) Class F24F 13/10 (20130101) F24F 13/14 (20130101) F24F 13/105 (20130101) F24F 2110/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199590 | Shashurin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexey Shashurin (West Lafayette, Indiana); Xingxing Wang (West Lafayette, Indiana) |
| ABSTRACT | Methods and systems capable of measuring gas temperatures utilizing plasma discharges. Such a method performs a measurement of a temperature of a gas by generating a probing nanosecond plasma pulse in the gas, and then using an optical emission spectroscopy technique to measure the temperature of the gas by processing a light emission signal excited by the probing nanosecond plasma pulse. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085856 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/67 (20130101) Original (OR) Class G01N 21/1702 (20130101) G01N 2021/1704 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199638 | Qian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fang Qian (Santa Cruz, California); Chao Huang (San Jose, California); Anna Nikolaevna Ivanovskaya (Mountain View, California); Kris Kulp (Livermore, California); Elizabeth K. Wheeler (Livermore, California) |
| ABSTRACT | A method includes simultaneously measuring electrophysiological responses and contractility responses of a plurality of cells forming a tissue culture using a system comprising a sensor array configured to simultaneously measure the electrophysiological responses and the contractility responses of the plurality of cells forming the tissue culture. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array. |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/144008 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 35/02 (20130101) C12M 41/46 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4836 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199737 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Jian Z. Hu (Richland, Washington); Nicholas R. Jaegers (Richmond, California); Mark R. Townsend (Kennewick, Washington); Mary Y. Hu (Richland, Washington) |
| ABSTRACT | A sample chamber holder for MAS-NMR capable of operating at both low and high pressures. In one example the sample chamber holder is made up of a sample holder body defining a sample chamber therein, a connector configured to operatively statically hold an in situ rotor within the sample chamber; a coupler configured to operatively connect the sampler holder body to a magnetically coupled rotation member. The magnetically coupled rotation member is configured to engage and rotate a sealing cap from an NMR rotor in such a way so as to allow an NMR cap to be alternatively opened or sealed in-situ while the NMR rotor remains statically positioned in an NMR device. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/072617 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/508 (20130101) B01L 9/00 (20130101) B01L 2200/026 (20130101) B01L 2300/0832 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) G01R 33/305 (20130101) G01R 33/307 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199841 | Labov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon E. Labov (Berkeley, California); Karl E. Nelson (Livermore, California); Brandon S. Seilhan (Emeryville, California) |
| ABSTRACT | A system identifying a source of radiation is provided. The system includes a radiation source detector and a radiation source identifier. The radiation source detector receives measurements of radiation; for one or more sources, generates a detection metric indicating whether that source is present in the measurements; and evaluates the detection metrics to detect whether a source is present in the measurements. When the presence of a source in the measurements is detected, the radiation source identifier for one or more sources, generates an identification metric indicating whether that source is present in the measurements; generates a null-hypothesis metric indicating whether no source is present in the measurements; evaluates the one or more identification metrics and the null-hypothesis metric to identify the source, if any, that is present in the measurements. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184171 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/36 (20130101) G01T 1/167 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/0075 (20130101) Original (OR) Class G01V 5/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202116 | Griffith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George W. Griffith (Idaho Falls, Idaho); Isabella J. van Rooyen (Idaho Falls, Idaho) |
| ABSTRACT | A nuclear fuel element comprises a core comprising a fissile element and an additional element, a first material surrounding the nuclear fuel, the first material comprising the fissile element and the additional element, the first material comprising a greater than stoichiometric amount of the additional element, and a metal around an outer portion of the nuclear fuel element. Related nuclear fuel elements, and related methods are disclosed. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/072903 |
| CURRENT CPC | Nuclear Reactors G21C 3/20 (20130101) Original (OR) Class G21C 3/28 (20130101) G21C 3/623 (20130101) G21C 3/626 (20130101) G21C 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202240 | Lagally et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); The Regents of the University of New Mexico (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Max G. Lagally (Madison, Wisconsin); Francesca Cavallo (Albuquerque, New Mexico); Vijay Saradhi Mangu (Albuquerque, New Mexico) |
| ABSTRACT | Methods for fabricating thin, high-aspect-ratio Ge nanostructures from high-quality, single-crystalline Ge substrates are provided. Also provided are grating structures made using the methods. The methods utilize a thin layer of graphene between a surface of a Ge substrate, and an overlying resist layer. The graphene passivates the surface, preventing the formation of water-soluble native Ge oxides that can result in the lift-off of the resist during the development of the resist. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/134783 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Optical Elements, Systems, or Apparatus G02B 5/3075 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0277 (20130101) H01L 21/02115 (20130101) Original (OR) Class H01L 21/3065 (20130101) H01L 21/8258 (20130101) H01L 27/0886 (20130101) H01L 29/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202257 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yuji Zhao (Chandler, Arizona); Houqiang Fu (Tempe, Arizona); Kai Fu (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuji Zhao (Chandler, Arizona); Houqiang Fu (Tempe, Arizona); Kai Fu (Tempe, Arizona) |
| ABSTRACT | A p-n diode includes a first electrode, a n-GaN layer on the first electrode, a p-GaN layer on the n-GaN layer, and a second electrode on a first portion of the p-GaN layer. A region of the p-GaN layer surrounding the electrode is a passivated region. Treating a GaN power device having a p-GaN layer includes covering a portion of the p-GaN layer with a metal layer, exposing the p-GaN layer to a hydrogen plasma, and thermally annealing the p-GaN layer, thereby passivating a region of the p-GaN layer proximate the metal layer. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/072622 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/3006 (20130101) Original (OR) Class H01L 21/3245 (20130101) H01L 23/585 (20130101) H01L 29/861 (20130101) H01L 29/2003 (20130101) H01L 29/66136 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202955 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Di-Jia LIU (Elmhurst, Illinois); Dominic REBOLLAR (New Lenox, Illinois) |
| ABSTRACT | A pyrolyzed MOF catalyst for in the carbon dioxide reduction reaction and methods of making the catalyst. The catalysts are composed of highly porous transition metal organic frameworks exhibiting large pores with regular distribution of transition metals within the structure. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200102 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1691 (20130101) B01J 37/086 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/25 (20210101) C25B 11/095 (20210101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/90 (20130101) H01M 4/9041 (20130101) Original (OR) Class H01M 4/9083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210204389 | Agustsson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RADIABEAM TECHNOLOGIES, LLC (Santa Monica, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald Agustsson (Venice, California); Salime Boucher (Santa Monica, California); Sergey Kutsaev (Santa Monica, California) |
| ABSTRACT | A particle accelerator can include a first waveguide portion and a second waveguide portion. The first waveguide portion can include a first plurality of cell portions and a first iris portion that is disposed between two of the first plurality of cell portions. The first iris portion can include a first portion of an aperture such that the aperture is configured to be disposed about a beam axis. The first waveguide portion can further include a first bonding surface. The second waveguide portion can include a second plurality of cell portions and a second iris portion that is disposed between two of the second plurality of cell portions. The second iris portion can include a second portion of the aperture. The second waveguide portion can include a second bonding surface. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180458 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/127 (20130101) H01P 11/002 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/16 (20130101) Original (OR) Class H05H 7/22 (20130101) H05H 2007/225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210196229 | BOCTOR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emad M. BOCTOR (Ellicott City, Maryland); Chloe AUDIGIER (Baltimore, Maryland); Younsu KIM (Baltimore, Maryland); Emran ANAS (Baltimore, Maryland); Arman RAHMIM (Baltimore, Maryland); Nicholas P.K. ELLENS (Baltimore, Maryland); Xiaoyu GUO (Baltimore, Maryland) |
| ABSTRACT | A system for monitoring an ablation therapy may include an ultrasound transmitter to transmit ultrasound signals through a region of tissue during an ablation procedure, an ultrasound receiver to receive the ultrasound signals after the ultrasound signals have passed through the region of tissue, and a signal processor to communicate with the ultrasound transmitter and the ultrasound receiver to obtain a set of measurements related to the ultrasound signals transmitted through the region of tissue during the ablation procedure. The signal processor may determine one or more acoustic characteristics of the ultrasound signals transmitted through the region of tissue based on the set of measurements and generate an image representing a thermal map of the region of tissue during the ablation procedure based on a mapping between the one or more acoustic characteristics of the ultrasound signals and changes in temperature. |
| FILED | Wednesday, May 29, 2019 |
| APPL NO | 17/057542 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) Original (OR) Class A61B 8/145 (20130101) A61B 8/485 (20130101) A61B 8/5223 (20130101) A61B 18/00 (20130101) A61B 2018/00577 (20130101) A61B 2018/00803 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196854 | Shanov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vesselin N. Shanov (Cincinnati, Ohio); Vibhor Chaswal (Cincinnati, Ohio); Pravahan Salunke (Cincinnati, Ohio); Madhura Joshi (Cincinnati, Ohio); Guangqi Zhang (Cincinnati, Ohio); Mark J. Schulz (West Chester, Ohio); Sergey N. Yarmolenko (Chapel Hill, North Carolina); Doug Nienaber (Loveland, Ohio) |
| ABSTRACT | A biomedical implant (16, 18) is formed from magnesium (Mg) single crystal (10). The biomedical implant (16, 18) may be biodegradable. The biomedical implant (16, 18) may be post treated to control the mechanical properties and/or corrosion rate thereof said Mg single crystal (10) without changing the chemical composition thereof. A method of making a Mg single crystal (10) for biomedical applications includes filling a single crucible (12) with more than one chamber with polycrystalline Mg, melting at least a portion of said polycrystalline Mg, and forming more than one Mg single crystal (10) using directional solidification. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/195997 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/80 (20130101) A61B 17/86 (20130101) A61B 2017/00526 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/3099 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/047 (20130101) Original (OR) Class A61L 27/58 (20130101) A61L 31/02 (20130101) A61L 31/022 (20130101) A61L 31/148 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 11/30 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 11/00 (20130101) C30B 11/02 (20130101) C30B 13/00 (20130101) C30B 15/00 (20130101) C30B 23/00 (20130101) C30B 25/00 (20130101) C30B 29/02 (20130101) C30B 33/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196989 | RINALDI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matteo RINALDI (Boston, Massachusetts); Flavius POP (Boston, Massachusetts); Bernard HERRERA (Cambridge, Massachusetts) |
| ABSTRACT | Implantable bio-heating and intrabody communication systems use arrays of piezoelectric micromachined ultrasonic transducers (pMUTs) to provide ultrasound-based diagnosis and treatment of medical conditions. Systems involving one or more pMUT arrays can be implanted into the body or integrating into smart ingestible pills to enable monitoring of a medical condition and/or continuous or intermittent application of hyperthermia and other treatments. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/121703 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) Original (OR) Class A61N 7/022 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0215 (20130101) B06B 1/0622 (20130101) B06B 2201/20 (20130101) B06B 2201/55 (20130101) B06B 2201/76 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210197146 | Weitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Adam R. Abate (Cambridge, Massachusetts); Tony Hung (Cambridge, Massachusetts); Pascaline Mary (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/145684 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 5/0471 (20130101) Original (OR) Class B01F 13/0071 (20130101) B01F 13/0072 (20130101) B01F 13/0076 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0093 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502784 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0017 (20130101) F16K 99/0051 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/206 (20150401) Y10T 137/0391 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210197191 | Haun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Jered Haun (Irvine, California); Xiaolong Qiu (Chula Vista, California); Elliot Hui (Arcadia, California); Amrith Karunaratne (Carson, California); Erik Werner (Irvine, California) |
| ABSTRACT | A microfluidic device uses hydrodynamic shear forces on a sample to improve the speed and efficiency of tissue digestion is disclosed. The microfluidic channels are designed to apply hydrodynamic shear forces at discrete locations on tissue specimens up to 1 cm in length and 1 mm in diameter, thereby accelerating digestion through hydrodynamic shear forces and improved enzyme-tissue contact. The microfluidic digestion device can eliminate or reduce the need to mince tissue samples with a scalpel, while reducing sample processing time and preserving cell viability. Another advantage is that downstream microfluidic operations could be integrated to enable advanced cell processing and analysis capabilities. The device may be used in research and clinical settings to promote single cell-based analysis technologies, as well as to isolate primary, progenitor, and stem cells for use in the fields of tissue engineering and regenerative medicine. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180711 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 2200/027 (20130101) B01L 2200/0647 (20130101) B01L 2300/042 (20130101) B01L 2300/0816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198157 | SANT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Gaurav SANT (Los Angeles, California); Kirk E. VANCE (Beverly Hills, California); Magdalena BALONIS (Los Angeles, California) |
| ABSTRACT | A manufacturing process of a cement product includes: (a) reacting at least one anhydrous or hydrated cement component with liquid or supercritical CO2 to form a cement composition; and (b) curing the cement composition to form a cement product. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/199215 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 11/245 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 28/04 (20130101) C04B 28/06 (20130101) C04B 28/10 (20130101) C04B 28/065 (20130101) C04B 28/105 (20130101) C04B 40/0231 (20130101) Original (OR) Class Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 40/18 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198171 | Papish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama); University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Papish (Tuscaloosa, Alabama); Aaron Vannucci (Columbia, South Carolina) |
| ABSTRACT | Disclosed are methods of selective hydrodeoxygenation of aromatic compounds by using catalyst systems comprising N-heterocyclic carbene (NHC) and 4-pyridinol-derived pincer ligands and metal complexes containing these ligands. |
| FILED | Thursday, October 01, 2020 |
| APPL NO | 17/060455 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2295 (20130101) B01J 2531/821 (20130101) Acyclic or Carbocyclic Compounds C07C 41/18 (20130101) Original (OR) Class C07C 2601/16 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198175 | Sibi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mukund P. Sibi (Fargo, North Dakota); Selvakumar Sermadurai (Kyoto, Japan); Nicolas Zimmermann (Treillères, France); Eric Serum (Eau Claire, Wisconsin); Gaoyuan Ma (Irvine, California); Ramkumar Moorthy (Saint Paul, Minnesota); Krystal Kalliokoski (Fargo, North Dakota) |
| ASSIGNEE(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| INVENTOR(S) | Mukund P. Sibi (Fargo, North Dakota); Selvakumar Sermadurai (Kyoto, Japan); Nicolas Zimmermann (Treillères, France); Eric Serum (Eau Claire, Wisconsin); Gaoyuan Ma (Irvine, California); Ramkumar Moorthy (Saint Paul, Minnesota); Krystal Kalliokoski (Fargo, North Dakota) |
| ABSTRACT | Compounds derived from biomass, e.g., cellulose and lignins, methods of forming such compounds and polymers and products formed using such compounds. |
| FILED | Friday, December 20, 2019 |
| APPL NO | 16/722710 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 57/34 (20130101) Original (OR) Class C07C 57/40 (20130101) C07C 59/64 (20130101) C07C 59/84 (20130101) Heterocyclic Compounds C07D 307/54 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/065 (20130101) C08G 63/181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198265 | Emrick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd Emrick (South Deerfield, Massachusetts); Matthew Skinner (Amherst, Massachusetts); Sarah M. Ward (Amherst, Massachusetts); Banishree Saha (Greenfield, Massachusetts) |
| ABSTRACT | A temozolomide compound according to formula (I) is described, wherein R1, L1, and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188162 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/787 (20130101) A61K 47/58 (20170801) A61K 47/60 (20170801) A61K 47/545 (20170801) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 22/10 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198291 | Toutov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute Of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton A. Toutov (Pasadena, California); Kerry N. Betz (Boulder, Colorado); Andrew M. Romine (San Diego, California); Robert H. Grubbs (South Pasadena, California) |
| ABSTRACT | The present disclosure is directed to hydrosilyl amines and fluorosilyl amines and methods of making the same. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/192129 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198533 | Peyton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shelly Peyton (Amherst, Massachusetts); John Klier (Leverett, Massachusetts); Yen Tran (Amherst, Massachusetts); Todd Emrick (South Deerfield, Massachusetts) |
| ABSTRACT | A crosslinkable polymer composition includes repeating units of formula (I) and repeating units derived from a monomer having an ethylenically unsaturated group and a crosslinkable functional group, wherein the crosslinkable functional group is capable of forming a covalent linkage with a crosslinkable functional group of an adjacent repeating unit. R1 and R2 are as defined herein. The crosslinkable polymer composition can be particularly useful, for example, for pressure sensitive adhesive or coating compositions. A method of making the polymer composition and a pressure sensitive adhesive and a coating are also described. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198706 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/20 (20130101) C08F 220/28 (20130101) C08F 220/34 (20130101) C08F 220/38 (20130101) C08F 220/281 (20200201) C08F 220/286 (20200201) C08F 220/382 (20200201) C08F 2800/10 (20130101) C08F 2810/20 (20130101) C08F 2810/50 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/385 (20180101) Original (OR) Class C09J 2301/414 (20200801) C09J 2433/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198806 | YU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Abalone Bio, Inc. (Richmond, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard YU (Richmond, California); Carlos Gustavo PESCE (Richmond, California); Rodrigo BALTANAS (Richmond, California); Brett ROBISON (Richmond, California) |
| ABSTRACT | Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display. |
| FILED | Monday, December 10, 2018 |
| APPL NO | 16/771128 |
| CURRENT CPC | Peptides C07K 16/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) C40B 30/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199543 | FEDOROV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrej G. FEDOROV (Atlanta, Georgia); Mason CHILMONCZYK (Atlanta, Georgia); Peter Arthur KOTTKE (Atlanta, Georgia) |
| ABSTRACT | The present disclosure provides for analysis systems that are configured to extract a fluid sample from a fluid (e.g., aqueous solution) in a reactor (e.g., bioreactor) at a first rate and then flow the fluid sample to a sensor system at a second rate to analyze the fluid sample. The sensor system can detect the presence and/or concentration of molecules (e.g., biomolecules such as biomarkers (e.g., metabolites, proteins, peptides, cytokines, growth factors, DNA, RNA, lipids) and cells of different types and cell properties, e.g., mechanical stiffness, etc.)). The data obtained can be used by a feedback control system to modify, as needed, the conditions in the reactor to enhance the productively of the reactor. |
| FILED | Thursday, August 15, 2019 |
| APPL NO | 17/265914 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 1/2035 (20130101) Original (OR) Class G01N 2001/205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199547 | Gomez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eliot Gomez (Cincinnati, Ohio); Andrew Jajack (North Canton, Ohio); Amy Drexelius (Covington, Kentucky) |
| ABSTRACT | Hydrogel-based or aerogel-based devices and methods for pretreatment of a sample. The devices and method may include an aerogel-based device for pretreating a sample comprising at least one aerogel; a hydrogel-based device for pretreating a sample comprising at least one hydrogel; or a combination aerogel-based and hydrogel-based device for pretreating a sample comprising at least one aerogel in fluid communication with at least one hydrogel. |
| FILED | Friday, June 07, 2019 |
| APPL NO | 15/734340 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) Original (OR) Class G01N 1/4077 (20130101) G01N 33/5436 (20130101) G01N 33/54313 (20130101) G01N 2001/2826 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199590 | Shashurin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexey Shashurin (West Lafayette, Indiana); Xingxing Wang (West Lafayette, Indiana) |
| ABSTRACT | Methods and systems capable of measuring gas temperatures utilizing plasma discharges. Such a method performs a measurement of a temperature of a gas by generating a probing nanosecond plasma pulse in the gas, and then using an optical emission spectroscopy technique to measure the temperature of the gas by processing a light emission signal excited by the probing nanosecond plasma pulse. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085856 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/67 (20130101) Original (OR) Class G01N 21/1702 (20130101) G01N 2021/1704 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210200058 | Halasyamani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | P. Shiv Halasyamani (Houston, Texas); Hongwei Yu (Houston, Texas); Hongping Wu (Houston, Texas); Weiguo Zhang (Houston, Texas) |
| ABSTRACT | A device comprising a nonlinear optical (NLO) material according to the formula XLi2Al4B6O20F. A device comprising a nonlinear optical material (NLO) according to the formula KSrCO3F, wherein the NLO comprises at least one single crystal. A nonlinear optical material selected from the group consisting of KSrCO3F Rb3Ba3Li2Al4B6O20F and K3Sr3Li2Al4B6O20F. |
| FILED | Friday, March 09, 2018 |
| APPL NO | 16/492261 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 7/54 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/20 (20130101) C01P 2002/60 (20130101) C01P 2002/80 (20130101) C01P 2004/61 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/12 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3551 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210201121 | Fink et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Yoel Fink (Brookline, Massachusetts); Gabriel Zi Jie Loke (Cambridge, Massachusetts); Tural Khudiyev (Revere, Massachusetts) |
| ABSTRACT | A fiber computer has a fiber body including electrically insulating fiber body material along the length of the fiber body. Electrical conductors are disposed within the fiber body and are operative to transmit electrical power, electrical ground, clock signals, and data signals through the fiber body. Input units disposed within the fiber body accept external stimuli. Microcontroller microchips disposed within the fiber body process stimuli accepted by an input unit. Memory module microchips within the fiber body store data and communicate with microcontroller microchips. Output units produce an output directed out of the fiber body. A clock signal generator within the fiber body synchronizes operation of input units, microcontroller microchips, memory module microchips, and output units. Each of the computer input units, microcontroller microchips, memory module microchips, and computer output units are disposed in electrical connection with the plurality of electrical conductors for fiber computer operation within the fiber body. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/086154 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/063 (20130101) Original (OR) Class Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) H01B 3/30 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/08 (20130101) H04R 1/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20210197194 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178824 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 2400/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198607 | WIKSWO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. WIKSWO (Brentwood, Tennessee); Eric C. SPIVEY (Nashville, Tennessee); David K. SCHAFFER (Nashville, Tennessee); Ronald S. REISERER (Nashville, Tennessee); Kevin T. SEALE (Nashville, Tennessee); Frank E. BLOCK, III (Potomac, Maryland) |
| ABSTRACT | One aspect of the invention provides a multichamber bioreactor. The multichamber bioreactor includes multiple planar layers stacked on each other defining at least one chamber and a clamping mechanism. The clamping mechanism includes a housing and retaining means received in the housing and configured to generate a controlled and uniform pressure to secure the stacked multiple planar layers in the housing. Each chamber is implemented from a separate fluidic layer, with each fluidic layer having ports and valves independent of the other layers. The micro fluidic ports can be actuated through a micro fluidic interconnect system utilizing rotary cylinder valves. |
| FILED | Wednesday, May 29, 2019 |
| APPL NO | 17/057267 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0247 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502715 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/44 (20130101) C12M 23/58 (20130101) C12M 29/00 (20130101) C12M 41/48 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/0045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198726 | McFarland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirsty A. McFarland (Melrose, Massachusetts); Andrew P. Magyar (Arlington, Massachusetts); Ting Pang (Cambridge, Massachusetts); Michael Springer (Brookline, Massachusetts) |
| ABSTRACT | Methods of detecting unknown genetic modifications in a DNA sample from an organism are disclosed. |
| FILED | Friday, October 12, 2018 |
| APPL NO | 16/755710 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210201136 | Chalamalasetti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sai Rahul Chalamalasetti (Milpitas, California); Paolo Faraboschi (Milpitas, California); Martin Foltin (Fort Collins, Colorado); Catherine Graves (Milpitas, California); Dejan S. Milojicic (Milpitas, California); John Paul Strachan (Milpitas, California); Sergey Serebryakov (Milpitas, California) |
| ABSTRACT | A crossbar array includes a number of memory elements. An analog-to-digital converter (ADC) is electronically coupled to the vector output register. A digital-to-analog converter (DAC) is electronically coupled to the vector input register. A processor is electronically coupled to the ADC and to the DAC. The processor may be configured to determine whether division of input vector data by output vector data from the crossbar array is within a threshold value, and if not within the threshold value, determine changed data values as between the output vector data and the input vector data, and write the changed data values to the memory elements of the crossbar array. |
| FILED | Monday, April 30, 2018 |
| APPL NO | 17/044633 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class Static Stores G11C 13/0069 (20130101) G11C 2213/77 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210196203 | Damaser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio); PARKER HANNIFIN CORPORATION (Cleveland, Ohio); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Margot S. Damaser (Cleveland, Ohio); Steve Majerus (Washington, District of Columbia); Hui Zhu (Cleveland, Ohio); Bradley C. Gill (Cleveland, Ohio); Ricardo Gonzalez (Cleveland, Ohio); Daniel Greene (Cleveland, Ohio); Joe Poliquin (Cleveland, Ohio); Glenn Craig (Cleveland, Ohio); Marie Lorentz (Cleveland, Ohio); Gino Banco (Cleveland, Ohio) |
| ABSTRACT | A sensing device can be used for ambulatory urodynamics. The sensing device can include an elongated outer housing constructed of flexible material that can curve within a patients bladder. At least a portion of the outer housing can be filled with a non-compressible fluid. A flexible printed circuit board can be disposed within the outer housing to curve with the outer housing. The printed circuit board can include a pressure sensor, comprising a diaphragm, to collect pressure data; a microcontroller miming control software; and a wireless transmitter to transmit the pressure data. A battery can be disposed within the outer housing and coupled to the printed circuit board. The flexible material of the outer housing is configured to be displaced by a pressure within the patients bladder, the displacement is transmitted through the non-compressible fluid to the pressure sensor that provides the pressure data based on the displacement. |
| FILED | Tuesday, May 28, 2019 |
| APPL NO | 17/058783 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/07 (20130101) A61B 5/204 (20130101) A61B 5/205 (20130101) A61B 5/0538 (20130101) A61B 5/6874 (20130101) Original (OR) Class A61B 2560/066 (20130101) A61B 2560/0209 (20130101) A61B 2562/06 (20130101) A61B 2562/164 (20130101) A61B 2562/166 (20130101) A61B 2562/168 (20130101) A61B 2562/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210196790 | Tyor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); MEIOGEN BIOTECHNOLOGY CORPORATION (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Tyor (Atlanta, Georgia); Rajeth Koneru (Cumming, Georgia); Jennifer Ward (Boston, Massachusetts); Leonard Maroun (Aurora, Colorado) |
| ABSTRACT | Disclosed are compositions comprising an interferon-alpha binding protein and combined anti-retroviral therapy (cART). In some aspects, the interferon-alpha binding protein is B18R. In some aspects, the compositions further comprise a pharmaceutically acceptable carrier. Disclosed are methods of treating a subject with HIV associated neurogenerative disorder (HAND) comprising administering a therapeutically effective amount of B18R and cART. Disclosed are methods of reversing behavioral abnormalities in subjects having HAND comprising administering a therapeutically effective amount of B18R. |
| FILED | Monday, October 15, 2018 |
| APPL NO | 16/755699 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/513 (20130101) A61K 31/675 (20130101) A61K 31/4418 (20130101) A61K 38/1793 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198221 | Patel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida); The United States Government as Represented by the Department of Veterans Affairs Office of General (Washington, District of Columbia) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida); The United States Government as Represented by the Department of Veterans Affairs Office of General (Washington, District of Columbia) |
| INVENTOR(S) | Niketa A. Patel (Tampa, Florida); Jianfeng Cai (Tampa, Florida) |
| ABSTRACT | Provided herein are compounds that can bind GAS5 long non-coding RNA, compositions thereof, and uses thereof. |
| FILED | Thursday, December 15, 2016 |
| APPL NO | 16/063077 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 285/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210199651 | ZENHAUSERN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederic ZENHAUSERN (Chandler, Arizona); Peng CHEN (Chandler, Arizona); Jian GU (Chandler, Arizona); Jerome LACOMBE (Chandler, Arizona) |
| ABSTRACT | Provided are vertical flow detection devices and related methods. The devices may comprise a membrane having a first surface and a second surface with a plurality of porous structures extending between the first and second surfaces to form fluid conduits from a first fluid chamber formed by the first surface and a second fluid chamber formed by the second fluid surface. A capture agent is immobilized on and/or in the membrane. A rigid porous membrane support mechanically supports the membrane and to provide a relatively uniform flow across the membrane. Various gaskets or holder elements are positioned around an outer edge of the membrane to prevent fluid leakage around the membrane. A fluid pump is configured to force a fluid sample flow in a direction from the first fluid chamber to the second fluid chamber. |
| FILED | Friday, March 29, 2019 |
| APPL NO | 17/040417 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2300/0877 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54386 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210202964 | Junaedi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRECISION COMBUSTION, INC. (North Haven, Connecticut) |
| ASSIGNEE(S) | PRECISION COMBUSTION, INC. (, None) |
| INVENTOR(S) | Christian Junaedi (Cheshire, Connecticut); Subir Roychoudhury (Madison, Connecticut); Kyle Hawley (Woodbury, Connecticut); Saurabh Vilekar (Woodbridge, Connecticut) |
| ABSTRACT | An individual solid oxide cell (SOC) constructed of a sandwich configuration including in the following order: an oxygen electrode, a solid oxide electrolyte, a fuel electrode, a fuel manifold, and at least one layer of mesh. In one embodiment, the mesh supports a reforming catalyst resulting in a solid oxide fuel cell (SOFC) having a reformer embedded therein. The reformer-modified SOFC functions internally to steam reform or partially oxidize a gaseous hydrocarbon, e.g. methane, to a gaseous reformate of hydrogen and carbon monoxide, which is converted in the SOC to water, carbon dioxide, or a mixture thereof, and an electrical current. In another embodiment, an electrical insulator is disposed between the fuel manifold and the mesh resulting in a solid oxide electrolysis cell (SOEC), which functions to electrolyze water and/or carbon dioxide. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193054 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/00 (20130101) C25B 1/04 (20130101) C25B 9/19 (20210101) C25B 9/70 (20210101) C25B 9/77 (20210101) C25B 11/00 (20130101) C25B 15/02 (20130101) C25B 15/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/12 (20130101) H01M 8/184 (20130101) H01M 8/0258 (20130101) H01M 8/0625 (20130101) H01M 8/0631 (20130101) H01M 8/2425 (20130101) H01M 8/2483 (20160201) H01M 8/04037 (20130101) Original (OR) Class H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210203085 | Jordan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cubic Corporation (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared W Jordan (Raleigh, North Carolina); Kenneth J Vanhille (Cary, North Carolina); Timothy A Smith (Durham, North Carolina); William Stacy (Blacksburg, Virginia); Benjamin L Cannon (Apex, North Carolina); David W Sherrer (Cary, North Carolina) |
| ABSTRACT | Antenna arrays, including a broadband single or dual polarized, tightly coupled radiator arrays. |
| FILED | Tuesday, June 19, 2018 |
| APPL NO | 16/076354 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/40 (20130101) H01Q 9/065 (20130101) H01Q 13/085 (20130101) H01Q 21/24 (20130101) H01Q 21/062 (20130101) H01Q 21/064 (20130101) H01Q 21/0093 (20130101) H01Q 25/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210198683 | Ulmasov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COVERCRESS INC. (ST. LOUIS, Missouri); BOARD OF TRUSTEES OF ILLINOIS STATE UNIVERSITY (Normal, Illinois); REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tim Ulmasov (Chesterfield, Missouri); John C. Sedbrook (Bloomington, Illinois); Michael David Marks (Roseville, Minnesota); Ratan Chopra (St. Paul, Minnesota) |
| ABSTRACT | Pennycress (Thlaspi arvense) seed, seed lots, seed meal, and compositions with reduced glucosinolate content as well as plants that yield such seed, seed lots, seed meal, and compositions are provided. Methods of making and using the pennycress plants and/or seed that provide such seed, seed lots, seed meal, and compositions are also provided. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/249431 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/10 (20130101) A01H 6/20 (20180501) Fodder A23K 10/30 (20160501) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210199658 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanping Chen (Laurel, Maryland); Matthew C. Heerman (Lanham, Maryland); Steven C. Cook (Capital Heights, Maryland); Jay D. Evans (Harwood, Maryland) |
| ABSTRACT | This disclosure relates generally to novel kits for measuring insect health, and to methods of making and using such compositions. More specifically, the invention relates to novel kits for a rapid and high-throughput measurement of lipase activity levels in insects, and the correlation of the measured lipase activity levels with insect stress. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135415 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 33/6839 (20130101) G01N 2333/43565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210197202 | Zayac et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Combinati Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Zayac (Belmont, California); Sammy Datwani (Pleasanton, California); Megan Dueck (San Francisco, California); Ju-Sung Hung (Palo Alto, California) |
| ABSTRACT | The present disclose provides devices, methods and systems that may be used for amplifying and quantifying nucleic acid molecules. Methods for amplifying and quantifying nucleic acids may comprise isolating a sample comprising nucleic acid molecules into a plurality of chambers, performing a polymerase chain reaction on the plurality of chambers, and analyzing the results of the polymerase chain reaction. |
| FILED | Tuesday, September 22, 2020 |
| APPL NO | 17/028839 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 7/52 (20130101) Original (OR) Class B01L 2200/0689 (20130101) B01L 2300/18 (20130101) B01L 2300/0609 (20130101) B01L 2300/0663 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210198288 | BURNS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VenatoRx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. BURNS (Malvern, Pennsylvania); Denis DAIGLE (Street, Maryland); Guo-Hua CHU (Exton, Pennsylvania); Jodie HAMRICK (New Holland, Pennsylvania); Steven A. BOYD (Chester Springs, Pennsylvania); Allison L. ZULLI (Chesterbrook, Pennsylvania); Eugen F. MESAROS (Wallingford, Pennsylvania); Stephen M. CONDON (Glenmoore, Pennsylvania); Robert E. Lee TROUT (Collegeville, Pennsylvania); Cullen L. MYERS (Exton, Pennsylvania); Zhenrong XU (Chalfont, Pennsylvania) |
| ABSTRACT | Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057593 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20210197231 | Bombaugh |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Bombaugh (Burke, Virginia) |
| ABSTRACT | Embodiments of a system and method for sorting and sequencing articles in a processing facility are disclosed. Delivery endpoints are divided and grouped into stop groups. A first sorter sorts items according to stop group and outputs the items to trays. The output trays from the first sorter are loaded to a second sorter in stop group order. The second sorter can then sort the items into output bins in delivery sequence order. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204637 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 1/025 (20130101) B07C 3/008 (20130101) Original (OR) Class B07C 3/10 (20130101) B07C 3/14 (20130101) B07C 2301/0041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210201249 | Crone |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald E. Crone (Frederick, Maryland) |
| ABSTRACT | An autonomous vehicle for delivery of items can detect its location and the location of targets on item receptacles in order to position the vehicle at a receptacle. The vehicle, in an autonomous mode, can automatically travel between delivery points along a delivery route. A presence sensor on the vehicle can detect ingress and egress from the vehicle to determine when the vehicle is ready to travel to the next delivery point. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198846 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/047 (20130101) G06Q 10/083 (20130101) Original (OR) Class G06Q 10/08355 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 20210196797 | Wagner |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Amy Kathleen Wagner (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure relates to methods, compositions, and kits for treating traumatic brain injury (TBI) and TBI-associated impairments in a subject. The methods include administering to the subject an interleukin-7 (IL-7) or IL-7 agonist, a TNFα inhibitor, or both. The present disclosure also relates to methods of using biomarkers for identifying a subject that is likely to respond to a treatment for TBI-associated impairments, and monitoring the subject's response to such treatment. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135970 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2046 (20130101) Original (OR) Class Peptides C07K 16/241 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/70578 (20130101) G01N 2800/28 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20210198660 | RASMUSSEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARC BIO, LLC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Morten RASMUSSEN (Cambridge, Massachusetts); Stephane B. GOURGUECHON (Cambridge, Massachusetts) |
| ABSTRACT | Provided are compositions and methods of making a guide nucleic acids (gNAs), methods of using gNAs, and ligation free methods of preparing libraries of nucleic acids for downstream applications such as high-throughput sequencing. |
| FILED | Friday, June 07, 2019 |
| APPL NO | 17/057390 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/1068 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20210197194 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178824 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 2400/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Leidos Biomedical Research, Inc
| US 20210196695 | MCCORMICK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Leidos Biomedical Research, Inc. (Frederick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank MCCORMICK (San Francisco, California); Adam R. Renslo (Oakland, California); David Turner (Frederick, Maryland); Stephan Gysin (Basel, Switzerland); Anna E. Maciag (Frederick, Maryland); Oleg Chertov (Frederick, Maryland) |
| ABSTRACT | Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/082125 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/445 (20130101) Original (OR) Class A61K 47/545 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 207/16 (20130101) C07D 211/28 (20130101) C07D 211/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 01, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
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THE PANEL
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FUNDED BY
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APPLICANT(S) and ASSIGNEES
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Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
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FILED
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3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
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CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
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