FedInvent Patent Applications
Patent Application Details for Thursday, July 22, 2021
This page was updated on Thursday, July 22, 2021 at 12:32 PM GMT
Department of Health and Human Services (HHS)
| US 20210219844 | Tearney et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guillermo J. Tearney (Cambridge, Massachusetts); Milen Shishkov (Watertown, Massachusetts); Brett Eugene Bouma (Quincy, Massachusetts); Benjamin J. Vakoc (Cambridge, Massachusetts); Norman S. Nishioka (Wayland, Massachusetts) |
| ABSTRACT | Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/130585 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0062 (20130101) A61B 5/0066 (20130101) A61B 5/0068 (20130101) A61B 5/0084 (20130101) Original (OR) Class A61B 5/6852 (20130101) A61B 5/7271 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10056 (20130101) G06T 2207/10101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210219849 | Rudin et al. |
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| FUNDED BY |
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| APPLICANT(S) | CANON MEDICAL SYSTEMS CORPORATION (Otawara-shi, Japan); THE JACOBS INSTITUTE, INC (Buffalo, New York) |
| ASSIGNEE(S) | CANON MEDICAL SYSTEMS CORPORATION (Otawara-shi, Japan); THE JACOBS INSTITUTE, INC (Buffalo, New York) |
| INVENTOR(S) | Stephen Rudin (Williamsville, New York); Eugene A. Mensah (Tustin, California); Andrew Kuhls-Gilcrist (Long Beach, California) |
| ABSTRACT | The present disclosure relates to a method for vascular imaging and determining dynamic vascular parameters of blood flow. According to an embodiment, the present disclosure relates to an apparatus and method of determining dynamic vascular parameters of blood flow, comprising acquiring two-dimensional projection images of a vascular region of interest at a predetermined frequency, the vascular region of interest being downstream of a site of vascular administration of a radio-opaque medium, identifying, within the acquired two-dimensional projection images, heterogeneities of the radio-opaque medium, and determining the dynamic vascular parameters of the blood flow based on spatial movements of the identified heterogeneities of the radio-opaque medium. In an embodiment, the predetermined frequency is greater than 100 Hz. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 16/795469 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/026 (20130101) Original (OR) Class A61B 5/02125 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 11/003 (20130101) G06T 2207/30048 (20130101) G06T 2207/30104 (20130101) G06T 2211/404 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210219852 | COLBURN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | David COLBURN (New York, New York); Samuel K. SIA (New York, New York) |
| ABSTRACT | The disclosed subject matter includes a wearable device for cuffless blood pressure monitoring that does not require external per-person calibration, such as with a cuff-based measurement device. The embodiment employs photoplethysmography sensors to obtain pulse wave velocity and develops compensation for external pressure influences. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204352 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/0245 (20130101) A61B 5/681 (20130101) A61B 5/02125 (20130101) Original (OR) Class A61B 5/02416 (20130101) A61B 5/7264 (20130101) A61B 8/488 (20130101) A61B 2560/0223 (20130101) A61B 2560/0261 (20130101) A61B 2562/0219 (20130101) A61B 2562/0223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210219898 | He et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin He (Minneapolis, Minnesota); Long Yu (Minneapolis, Minnesota) |
| ABSTRACT | A system and method for cardiac activation imaging includes non-invasively or minimally invasively acquiring data about an electrical activation of a heart of a subject using at least one sensor. An activation image of the heart of the subject is reconstructed using a weighted sparse constrained reconstruction. |
| FILED | Wednesday, September 02, 2020 |
| APPL NO | 17/010264 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0044 (20130101) A61B 5/055 (20130101) A61B 5/282 (20210101) A61B 5/316 (20210101) Original (OR) Class A61B 5/318 (20210101) A61B 5/349 (20210101) A61B 5/7282 (20130101) A61B 6/032 (20130101) A61B 6/503 (20130101) A61B 6/5205 (20130101) A61B 2576/023 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210219899 | He et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin He (Arden Hills, Minnesota); Zhaoye Zhou (Minneapolis, Minnesota) |
| ABSTRACT | A system and method for non-invasively generating a report of cardiac electrical activities of a subject includes determining, using cardiac electrical activation information, equivalent current densities (ECDs). The ECDs are assembled into time-course ECD information and a spectrum of the time-course ECD information is analyzed to determine peaks for spectral characteristics of atrial fibrillation (AF). The spectral characteristics of AF are correlated with potential electrical sources of the AF and a report is generated indicating the potential electrical sources of the AF spatially registered with the medical imaging data. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/013003 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/316 (20210101) Original (OR) Class A61B 5/333 (20210101) A61B 5/361 (20210101) A61B 6/032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210219933 | Boone et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | John M. Boone (Sacramento, California); George W. Burkett (Sacramento, California) |
| ABSTRACT | A multimodal system for breast imaging includes an x-ray source, and an x-ray detector configured to detect x-rays from the x-ray source after passing through a breast. The system includes an x-ray detector translation system operatively connected to the x-ray detector so as to be able to translate the x-ray detector from a first displacement from the breast to a second displacement at least one of immediately adjacent to or in contact with the breast. The system includes an x-ray image processor configured to: receive a CT data set from the x-ray detector, the CT data set being detected by the x-ray detector at the first displacement; compute a CT image of the breast; receive a mammography data set from the x-ray detector, the mammography data set being detected by the x-ray detector at the second displacement; and compute a mammography image of the breast. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152188 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/54 (20130101) A61B 6/0414 (20130101) A61B 6/0421 (20130101) A61B 6/461 (20130101) A61B 6/467 (20130101) A61B 6/487 (20130101) A61B 6/502 (20130101) Original (OR) Class A61B 6/4085 (20130101) A61B 6/4291 (20130101) A61B 6/4447 (20130101) A61B 6/4452 (20130101) A61B 10/0041 (20130101) A61B 34/30 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220287 | Green et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan Jamieson Green (Nottingham, Maryland); Aleksander S. Popel (Lutherville, Maryland); Joel Chaim Sunshine (Pikesville, Maryland); Ron B. Shmueli (Baltimore, Maryland); Stephany Yi Tzeng (Baltimroe, Maryland); Kristen Lynn Kozielski (Baltimore, Maryland) |
| ABSTRACT | Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149583 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 9/19 (20130101) A61K 9/5026 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 31/711 (20130101) A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 38/39 (20130101) A61K 47/34 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) C12N 15/111 (20130101) C12N 2310/14 (20130101) C12N 2320/32 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2982 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220315 | Freeman et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Bruce A. Freeman (Pittsburgh, Pennsylvania); Francisco J. Schopfer (Pittsburgh, Pennsylvania) |
| ABSTRACT | Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-γ. |
| FILED | Tuesday, November 17, 2020 |
| APPL NO | 16/950805 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/20 (20130101) A61K 31/201 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220322 | Dagda et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the Nevada System of Higher Education,on Behalf of the University of Navada,Reno (Reno, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raul Y. Dagda (Reno, Nevada); Ruben K. Dagda (Reno, Nevada) |
| ABSTRACT | The present invention relates to the discovery that Forskolin can be used to treat Parkinson's disease (PD) in subjects in need thereof. In certain embodiments, the invention provides a method of treating PD, wherein a therapeutically effective amount of Forskolin is administered to a subject via intranasal or intrapulmonary routes. In other embodiments, the subject is further administered a therapeutically effective amount of Noopept. In yet other embodiments, the method reverses damage to the subject's brain caused by PD and promotes growth of new neurons. |
| FILED | Thursday, June 20, 2019 |
| APPL NO | 17/055349 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/12 (20130101) A61K 9/0043 (20130101) A61K 31/352 (20130101) Original (OR) Class A61K 31/4015 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220329 | Reinhold et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE (Bathesda, Maryland); GENOME RESEARCH LIMITED (London, United Kingdom); DANA FARBER CANCER INSTITUTE (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Curtis Reinhold (Rockville, Maryland); Mathew Garnett (Cambridge, United Kingdom); Vinodh Nalin Rajapakse (Rockville, Maryland); Yves Pommier (Bethesda, Maryland); Augustin Luna (Brookline, Massachusetts) |
| ABSTRACT | The disclosure provides a method of treating triple negative breast cancer in a patient, comprising administering a therapeutically effective amount of a compound selected from oxyphenisatin, oxyphenisatin acetate, and bisacodyl, or the pharmaceutically acceptable salts or hydrates of any of the foregoing to the patient. The disclosure also provides methods of using oxyphenisatin or bisacodyl, or a salt or hydrate thereof, as a first active agent in combination with one or more additional active agents to treat triple negative breast cancer. The disclosure further provides methods for determining whether a patient suffering from triple negative breast cancer would be responsive to treatment with oxyphenisatin or bisacodyl. |
| FILED | Friday, February 08, 2019 |
| APPL NO | 16/967472 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/131 (20130101) A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 31/404 (20130101) Original (OR) Class A61K 31/475 (20130101) A61K 31/513 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/4402 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220331 | Gera et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The United State Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph F. Gera (Lancaster, California); Alan Lichtenstein (Encino, California); Michael E. Jung (Los Angeles, California); Jihye Lee (Yeonsu-gu, Incheon, South Korea); Brent Holmes (Inglewood, California); Angelica Benavides-Serrato (Grenada Hills, California) |
| ABSTRACT | This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors. |
| FILED | Wednesday, May 03, 2017 |
| APPL NO | 16/098784 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 31/502 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/4015 (20130101) Original (OR) Class A61K 31/4035 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 207/448 (20130101) C07D 207/452 (20130101) C07D 207/456 (20130101) C07D 209/48 (20130101) C07D 217/24 (20130101) C07D 237/32 (20130101) C07D 239/54 (20130101) C07D 239/96 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220354 | XIONG et al. |
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| FUNDED BY |
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| APPLICANT(S) | MOREHOUSE SCHOOL OF MEDICINE (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhigang XIONG (Atlanta, Georgia); Roger P. SIMON (Atlanta, Georgia) |
| ABSTRACT | This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/248952 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/00 (20130101) A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 31/40 (20130101) A61K 31/55 (20130101) A61K 31/155 (20130101) A61K 31/4965 (20130101) Original (OR) Class Peptides C07K 14/43518 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220388 | Segura et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Tatiana Segura (Durham, North Carolina); Stanley Thomas Carmichael (Sherman Oaks, California); Lina R. Nih (Redondo Beach, California) |
| ABSTRACT | A therapeutic hydrogel material includes a hyaluronic acid-based hydrogel matrix containing naked heparin nanoparticles distributed and entrained within the matrix. The naked heparin nanoparticles contained in the matrix are not immobilized to any other molecules at the time of delivery. In one aspect of the invention, the therapeutic hydrogel material is used to repair ischemic tissue in a subject (e.g., mammal). The therapeutic hydrogel material may also be used to treat wounds or other damaged tissue. To treat the subject or patient, the site of application is located and the therapeutic hydrogel material is injected or otherwise delivered (with or without a delivery device) to the delivery location along with a crosslinker. |
| FILED | Thursday, May 10, 2018 |
| APPL NO | 17/054421 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1695 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/14 (20130101) A61K 31/727 (20130101) Original (OR) Class A61K 47/18 (20130101) A61K 47/36 (20130101) A61K 47/42 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220390 | Embury |
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| FUNDED BY |
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| APPLICANT(S) | Vanguard Therapeutics, Inc. (Half Moon Bay, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen H. Embury (Half Moon Bay, California) |
| ABSTRACT | This invention is directed to, inter alia, compositions comprised of pentosan polysulfate sodium (PPS) components and methods for making such compositions and using the same for the treatment of sickle cell disease (SCD). The disclosed compositions possess superior bioavailability as well as P-selectin blocking activity for the treatment of sickle-cell disease (SCD). Methods for using the same are additionally provided herein. Also provided herein is a method for detecting or quantifying PPS or a PPS fraction in solutions or in a biological sample obtained from an animal or an individual. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/132885 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/737 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) Polysaccharides; Derivatives Thereof C08B 37/0057 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220391 | Johnson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremiah A. Johnson (Boston, Massachusetts); Hung Vanthanh Nguyen (Cambridge, Massachusetts); Yivan Jiang (Revere, Massachusetts); Alexandre Detappe (Strasbourg, France); Michael Agius (Boston, Massachusetts); Irene Ghobrial (Boston, Massachusetts) |
| ABSTRACT | Disclosed multifunctional compounds, conjugates, macromolecules, and polymers that target dysregulated proteins for degradation. Also disclosed are methods of preparation, compositions, kits, and methods of use relating to the degraders. |
| FILED | Tuesday, November 10, 2020 |
| APPL NO | 17/093832 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/795 (20130101) Original (OR) Class A61K 47/55 (20170801) A61K 47/60 (20170801) Heterocyclic Compounds C07D 495/14 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) C08G 65/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220401 | Discher et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis E. Discher (Philadelphia, Pennsylvania); Kyle R. Spinler (La Jolla, California); Cory Alvey (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods that provide novel therapies in cancer. The invention includes a phagocytic cell modified with a repressor of signal regulatory protein-alpha (SIRPα) and bound to a targeting antibody to enhance phagocytic activity of the phagocytic cell toward tumor tissue. Methods of enhancing phagocytic activity and treating a tumor are also included. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/198103 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) Original (OR) Class A61K 35/28 (20130101) A61K 47/6851 (20170801) A61K 49/0041 (20130101) A61K 49/0097 (20130101) A61K 2035/124 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0645 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220403 | METELITSA et al. |
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| FUNDED BY |
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| APPLICANT(S) | Leonid S. METELITSA (Sugar Land, Texas); Daofeng Liu (Houston, Texas); Gianpietro Dotti (Houston, Texas); Andras Heczey (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Leonid S. METELITSA (Sugar Land, Texas); Daofeng Liu (Houston, Texas); Gianpietro Dotti (Houston, Texas); Andras Heczey (Houston, Texas) |
| ABSTRACT | The present invention regards methods and/or compositions related to Natural Killer T cells that are engineered to harbor an expression construct that encodes IL-2, IL-4, IL-7, and/or IL-15 and additionally or alternatively comprise a chimeric antigen receptor (CAR). In specific embodiments, the CAR is a CAR that targets the GD2 antigen, for example in neuroblastoma. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/071511 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) A61K 31/4545 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 39/00 (20130101) A61K 39/0011 (20130101) A61K 39/001171 (20180801) A61K 45/06 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) A61K 2039/55527 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) C12N 2500/02 (20130101) C12N 2501/2315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220434 | Wang |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Rong Wang (San Francisco, California) |
| ABSTRACT | Provided are novel treatments for treating various conditions of insufficient blood flow or circulation. The novel inventions disclosed herein are based upon the discovery that increased Notch signaling in arterial vessels has a beneficial effect on blood flow or circulation and tissue regeneration as well as a reduction in tissue damage following arterial occlusion, constriction, or other reduction in blood flow. Increased Notch signaling in arteries promotes beneficial effects, including acute vessel dilation and/or arteriogenesis and collateral arterial growth, and improves recovery following ischemia or other reduced circulation condition. Also provided are medical devices for the delivery of Notch-activating agents to blood vessels. |
| FILED | Thursday, July 25, 2019 |
| APPL NO | 17/262460 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/19 (20130101) A61K 31/26 (20130101) A61K 31/517 (20130101) A61K 31/4741 (20130101) A61K 35/18 (20130101) A61K 35/19 (20130101) A61K 38/177 (20130101) Original (OR) Class A61K 47/6803 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220438 | Ix et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joachim Ix (La Jolla, California); Michael Shlipak (San Francisco, California) |
| ABSTRACT | The present disclosure provides a panel of biomarkers for use in diagnosing and/or monitoring kidney health during a therapeutic treatment for a therapeutic regimen that induces renal impairment or chronic kidney disease. Such monitoring may be useful in subjects undergoing treatment a disease such as diabetes mellitus and/or hypertension, where a therapeutic regimen results in increased levels of blood creatinine. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/20 (20130101) A61K 38/1722 (20130101) Original (OR) Class A61K 38/1741 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220439 | Wagner |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEMS OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Amy Kathleen Wagner (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure relates to methods and compositions for treating traumatic brain injury (TBI) and TBI-associated impairments and improving outcome in subjects that have sustained traumatic brain injury comprising administering to the subject a sgp130 or an agent that promotes the binding of sgp130 and sIL-6R and/or reduces sIL-6R mediated trans-signaling. The present disclosure also relates to methods and kits for identifying a subject that is at risk of developing a TBI-associated impairment (e.g., headache, depression, cognitive deficits, and seizure) or monitoring the responsiveness to a treatment regimen for a TBI-associated impairment in the subject, using biomarkers (e.g., white blood cells indices (e.g., Neutrophil-Lymphocyte Ratio (NLR), absolute lymphocyte counts), sIL-6R, sgp130, IL-6, sgp130:sIL-6R ratio, sIL-2Ra, IL-2, sIL-2Ra:IL-2 ratio, TNFα, TNFRI, and TNFRI:TNFα ratio). |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135946 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1793 (20130101) Original (OR) Class A61K 47/6811 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/5412 (20130101) G01N 2333/7155 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220441 | Mulé et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | h. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Mulé (Odessa, Florida); Rana Falahat (Tampa, Florida); Genyuan Zhu (Columbia, South Carolina) |
| ABSTRACT | As disclosed herein, stromal cells are important for the recruitment and organization of lymphocytes in TLSs. Therefore, disclosed herein are composition and methods for bioengineering TLSs in animals, such as mice. These compositions involve chemokine-releasing microparticles or cells that can be implanted into the animals. Therefore, disclosed herein are chitosan hydrogels with chemokine releasing microparticles or cells. |
| FILED | Wednesday, May 08, 2019 |
| APPL NO | 17/052973 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 35/26 (20130101) A61K 38/191 (20130101) A61K 38/195 (20130101) Original (OR) Class A61K 47/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220450 | Danias |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Ioannis (John) Danias (Staten Island, New York) |
| ABSTRACT | Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175213 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/482 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Enzymes C12Y 304/21068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220454 | Mirkin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Shuya Wang (Evanston, Illinois); Kacper Skakuj (Durham, North Carolina); Xiaoyi S. Hu (Acton, Massachusetts) |
| ABSTRACT | The disclosure is generally directed to immunostimulatory protein-core spherical nucleic acids (SNAs) comprising a protein core and a ratio of immunostimulatory and non-immunostimulatory strands, methods of making the immunostimulatory protein-core SNAs as well as their use. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 16/886712 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/804 (20180801) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220455 | Hacohen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana Farber Cancer Institute, Inc. (Boston, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nir Hacohen (Brookline, Massachusetts); Catherine Ju-Ying Wu (Brookline, Massachusetts); Edward F. Fritsch (Concord, Massachusetts) |
| ABSTRACT | The invention provides a method of making a personalized neoplasia vaccine for a subject diagnosed as having a neoplasia, which includes identifying a plurality of mutations in the neoplasia, analyzing the plurality of mutations to identify a subset of at least five neo-antigenic mutations predicted to encode neo-antigenic peptides, the neo-antigenic mutations selected from the group consisting of missense mutations, neoORF mutations, and any combination thereof, and producing, based on the identified subset, a personalized neoplasia vaccine. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/089408 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/70 (20130101) A61K 2039/80 (20180801) A61K 2039/545 (20130101) A61K 2039/55561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220457 | Tran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Eric Tran (Portland, Oregon); Yong-Chen Lu (Rockville, Maryland); Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed are methods of isolating T cells having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous APCs of the patient to present the mutated amino acid sequence; co-culturing autologous T cells of the patient with the autologous APCs that present the mutated amino acid sequence; and selecting the autologous T cells. Also disclosed are related methods of preparing a population of cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195072 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 2039/5158 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220475 | Crew et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arvinas Operations, Inc. (New Haven, Connecticut); Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew P. Crew (Chester, Connecticut); Kurt Zimmermann (Durham, Connecticut); Jing Wang (Milford, Connecticut); Craig M. Crews (New Haven, Connecticut); Saul Jaime-Figueroa (Morris Plains, New Jersey); George Burslem (Sandwich, United Kingdom) |
| ABSTRACT | The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) TBK1. In particular, the present invention is directed to compounds, which contain on one end an E3 ubiquitin ligase binding moiety which binds to an E3 ubiquitin ligase and on the other end a moiety which binds TBK1 such that TBK1 is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of TBK1. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of TBK1. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/192083 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/55 (20130101) A61K 31/427 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/551 (20130101) A61K 38/07 (20130101) A61K 45/06 (20130101) A61K 47/55 (20170801) A61K 47/545 (20170801) Original (OR) Class Heterocyclic Compounds C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220482 | Rao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianghong Rao (Palo Alto, California); Liyang Cui (Sunnyvale, California) |
| ABSTRACT | Provided is a mitochondrial copper depleting strategy that exploits the potential vulnerability for this metabolic by cancer cells such as Triple Negative Breast Cancer cells. A nanoparticle is provided that comprises a self-reporting copper-depleting moiety (CDM) embedded in or on the matrix comprising a semi-conducting polymer and a phospholipid-polyethylene glycol (PEG). The positively charged copper-depleting complex targets mitochondria and deprives cytochrome c oxidase of its necessary copper co-factor. Inhibition of the electron transport chain complex IV compromises oxygen consumption and abrogates fatty acid oxidation, resulting in energy deficiency induced apoptosis of the targeted cancer cells. The copper-depleting nanoparticle can report the copper depleting status through multimodal optical signal changes while decreasing the copper level in tumors to inhibit tumor growth with low toxicity and significantly prolonged survival. |
| FILED | Wednesday, December 09, 2020 |
| APPL NO | 17/116357 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 31/4439 (20130101) A61K 47/6935 (20170801) Original (OR) Class A61K 49/222 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220483 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark E. Davis (Pasadena, California); Emily A. Wyatt (Encino, California) |
| ABSTRACT | The present application discloses nanoparticles carrying therapeutic agents, including chemotherapeutic agents, and targeting ligands suitable for delivering these therapeutic agents through the blood brain barrier and methods of using these patients on those patients in need of such treatment. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215443 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1641 (20130101) A61K 31/137 (20130101) A61K 31/4045 (20130101) A61K 31/4745 (20130101) A61K 47/6935 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 16/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220484 | Martin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDEREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Taylor Martin (Columbus, Ohio) |
| ABSTRACT | The present disclosure relates to recombinant adeno-associated virus (rAAV) delivery of a GALGT2 polynucleotide. The disclosure provides rAAV and methods of using the rAAV for GALGT2 gene therapy of neuromuscular disorders. Exemplary neuromuscular disorders include, but are not limited to, muscular dystrophies such as Duchenne muscular dystrophy, Congenital Muscular Dystrophy 1A and Limb Girdle Muscular Dystrophy 2D. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/203232 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1048 (20130101) C12N 9/1051 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2830/008 (20130101) C12N 2830/42 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Enzymes C12Y 204/01165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220487 | Kaspar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian K. Kaspar (Columbus, Ohio); Arthur Burghes (Columbus, Ohio); Paul Porensky (Columbus, Ohio) |
| ABSTRACT | The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-osmolar contrast agent, together with a rAAV9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 48/00 (20130101) A61K 48/0008 (20130101) A61K 48/0075 (20130101) Original (OR) Class A61K 49/0438 (20130101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220489 | Scherrer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Scherrer (Chapel Hill, North Carolina); Mark Schnitzer (Redwood City, California); Benjamin Grewe (Zurich, Switzerland); Dong Wang (Palo Alto, California); Biafra Ahanonu (San Francisco, California); Gregory Corder (Philadelphia, Pennsylvania) |
| ABSTRACT | An ensemble of neurons in the basolateral amygdala (BLA) has been identified that encodes nociceptive information across pain modalities, including pain evoked by noxious thermal and mechanical stimuli. Methods are provided for screening candidate agents for inhibition of neural activity of the BLA nociceptive ensemble. Screening assays further include determining the effectiveness of candidate agents in alleviating pain and reducing aversive pain avoidance behavior. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/148377 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 49/0004 (20130101) Original (OR) Class Peptides C07K 16/28 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220490 | Schnermann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Martin J. Schnermann (Rockville, Maryland); Megan S. Michie (Frederick, Maryland) |
| ABSTRACT | Conformationally restricted cyanine fluorophores, as well as methods of making and using the compounds, are described. The conformationally restricted cyanine fluorophores have a chemical structure according to Formula I, or a stereoisomer or pharmaceutically acceptable salt thereof: wherein A is and wherein each “*” designates an attachment point of A. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/198004 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) Original (OR) Class A61K 2123/00 (20130101) Heterocyclic Compounds C07D 491/147 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220494 | Bradbury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle S. Bradbury (New York, New York); Michael Overholtzer (New York, New York); Cameron Brennan (Haworth, New Jersey); Barney Yoo (New York, New York); Jedd D. Wolchok (New York, New York); Ulrich Wiesner (Ithaca, New York) |
| ABSTRACT | Described herein are nanoparticle conjugates that demonstrate enhanced penetration of tumor tissue (e.g., brain tumor tissue) and diffusion within the tumor interstitium, e.g., for treatment of cancer. Further described are methods of targeting tumor-associated macrophages, microglia, and/or other cells in a tumor microenvironment using such nanoparticle conjugates. Moreover, diagnostic, therapeutic, and theranostic (diagnostic and therapeutic) platforms featuring such nanoparticle conjugates are described for treating targets in both the tumor and surrounding microenvironment, thereby enhancing efficacy of cancer treatment. Use of the nanoparticle conjugates described herein with other conventional therapies, including chemotherapy, radiotherapy, immunotherapy, and the like, is also envisaged. |
| FILED | Friday, April 28, 2017 |
| APPL NO | 16/095780 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6923 (20170801) A61K 47/6929 (20170801) A61K 51/0474 (20130101) A61K 51/1244 (20130101) Original (OR) Class A61K 2121/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220656 | Lujan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Luis Lujan (Mayfield Heights, Ohio); Ashutosh Chaturvedi (Powell, Ohio); Cameron McIntyre (Cleveland, Ohio) |
| ABSTRACT | A computer-implemented method for determining the volume of activation of neural tissue. In one embodiment, the method uses one or more parametric equations that define a volume of activation, wherein the parameters for the one or more parametric equations are given as a function of an input vector that includes stimulation parameters. After receiving input data that includes values for the stimulation parameters and defining the input vector using the input data, the input vector is applied to the function to obtain the parameters for the one or more parametric equations. The parametric equation is solved to obtain a calculated volume of activation. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/203044 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36185 (20130101) A61N 1/37252 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220665 | RUIZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Alberto J. RUIZ (Hanover, New Hampshire); Ethan P.M. LAROCHELLE (Thetford Center, Vermont); Brian POGUE (Hanover, New Hampshire) |
| ABSTRACT | While clinical treatment of actinic keratosis by photodynamic therapy (PDT) is widely practiced, there is well-known variability in response, primarily caused by heterogeneous accumulation and PDT-induced photobleaching of the photosensitizer protoporphyrin IX (PpIX) between patients and between lesions. One of the key factors in regularizing this treatment would be to have an easily accessible indicator of PpIX present in the lesions at the time of light delivery. Described herein, a smartphone-based fluorescence imager was developed to allow simple quantitative photography of the lesions and their PpIX levels. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154430 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Original (OR) Class A61N 2005/063 (20130101) A61N 2005/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220780 | LOUSENBERG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Compact Membrane Systems Inc. (Newport, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ROBERT D. LOUSENBERG (WILMINGTON, Delaware); EVAN A. SOHODSKI (HOCKESSIN, Delaware); KENNETH J. PENNISI (BEAR, Delaware) |
| ABSTRACT | This invention discloses a thin-film composite thin-film composite membrane that is useful for the separation of solute species in organic solvents and particularly in aggressive, high boiling-point, polar-aprotic solvents such as dimethylsulfoxide, (DMSO), N-Methyl-2-pyrrolidone (NMP), dimethylacetamide (DMAc), dimethylformamide (DMF). Thin-film composite separation performance and durability is greatly enhanced through electrostatic crosslinking of an ionomer selective layer by incorporation of a multi-valent counter-ion. The thin-film composite is resistant to contact with amines and the separation efficiency is tunable by choice of multi-valent counter-ion or through the applied pressure differential across the membrane. |
| FILED | Monday, January 14, 2019 |
| APPL NO | 15/734029 |
| CURRENT CPC | Separation B01D 67/0083 (20130101) B01D 69/02 (20130101) B01D 69/10 (20130101) B01D 69/12 (20130101) B01D 71/32 (20130101) Original (OR) Class B01D 2323/30 (20130101) B01D 2323/36 (20130101) B01D 2325/04 (20130101) B01D 2325/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220822 | Cummins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian M. Cummins (Raleigh, North Carolina); Frances Smith Ligler (Fuquay Varina, North Carolina); Glenn Walker (Cary, North Carolina) |
| ABSTRACT | Provided herein are passive microfluidic pumps. The pumps can comprise a fluid inlet, an absorbent region, a resistive region fluidly connecting the fluid inlet and the absorbent region, and an evaporation barrier enclosing the resistive region, the absorbent region, or a combination thereof. The resistive region can comprise a first porous medium, and a fluidly non-conducting boundary defining a path for fluid flow through the first porous medium from the fluid inlet to the absorbent region. The absorbent region can comprise a fluidly non-conducting boundary defining a volume of a second porous medium sized to absorb a predetermined volume of fluid imbibed from the resistive region. The resistive region and the absorbent region can be configured to establish a capillary-driven fluid front advancing from the fluid inlet through the resistive region to the absorbent region when the fluid inlet is contacted with fluid. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200464 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 3/50273 (20130101) Original (OR) Class B01L 3/502746 (20130101) B01L 2200/06 (20130101) B01L 2200/12 (20130101) B01L 2200/027 (20130101) B01L 2300/12 (20130101) B01L 2300/069 (20130101) B01L 2300/087 (20130101) B01L 2300/126 (20130101) B01L 2300/0816 (20130101) B01L 2300/0883 (20130101) B01L 2300/0887 (20130101) B01L 2400/084 (20130101) B01L 2400/0406 (20130101) B01L 2400/0457 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 19/006 (20130101) F04B 19/16 (20130101) F04B 37/02 (20130101) F04B 37/04 (20130101) Pumping of Fluid by Direct Contact of Another Fluid or by Using Inertia of Fluid to be Pumped; Siphons F04F 99/00 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2280/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220872 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Ma (Palo Alto, California); Kamyar Firouzi (Palo Alto, California); Butrus T. Khuri-Yakub (Palo Alto, California); Jose Joseph (Stanford, California) |
| ABSTRACT | Aspects of this disclosure relate to driving a capacitive micromachined ultrasonic transducer (CMUT) with a pulse train of unipolar pulses. The CMUT may be electrically excited with a pulse train of unipolar pulses such that the CMUT operates in a continuous wave mode. In some embodiments, the CMUT may have a contoured electrode. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152563 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0215 (20130101) Original (OR) Class B06B 1/0651 (20130101) B06B 1/0662 (20130101) B06B 2201/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220873 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Ma (Palo Alto, California); Jose Joseph (Stanford, California); Kamyar Firouzi (Palo Alto, California); Butrus T. Khuri-Yakub (Palo Alto, California) |
| ABSTRACT | Aspects of this disclosure relate to a capacitive micromachined ultrasonic transducer (CMUT) with a contoured electrode. In certain embodiments, the CMUT has a contoured electrode. The electrode may be non-planar to correspond to a deflected shape of the outer plate. A change in distance between the electrode and the plate after deflection may be greater than a minimum threshold across the width of the CMUT. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152555 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0215 (20130101) B06B 1/0292 (20130101) Original (OR) Class Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0021 (20130101) B81B 2201/0271 (20130101) B81B 2203/04 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00166 (20130101) B81C 2201/0157 (20130101) B81C 2201/0178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221715 | WILSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Justin WILSON (Ithaca, New York); Nikki THIELE (Brooktondale, New York) |
| ABSTRACT | Metal-chelating compositions having the structure (1a) wherein: R1, R2, R3, and R4 are independently selected from the following groups: (i) hydrogen atom, (ii) hydrocarbon groups (R) containing 1-12 carbon atoms; (iii) halogen atoms; (iv) —P(R5)(═O)OH groups; (v) —C(═O)OH groups; (vi) —S(═O)2OH groups; and (vii) —OH groups, wherein R5 is selected from hydrocarbon groups (R) and —OH; R1 and R2 may optionally interconnect to form Ring A fused to the ring on which R1 and R2 are present; R3 and R4 may optionally interconnect to form Ring B fused to the ring on which R3 and R4 are present; wherein Ring A and Ring B are optionally and independently substituted with one or more of groups (ii)-(vii). Methods of using the above-described compositions for chelating metal ions having an atomic number of at least 56 (e.g., Ba or Ra) are also described. |
| FILED | Friday, May 31, 2019 |
| APPL NO | 15/734061 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/683 (20130101) Original (OR) Class C02F 5/12 (20130101) C02F 5/14 (20130101) C02F 2101/006 (20130101) Heterocyclic Compounds C07D 413/14 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6533 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221790 | OGASAWARA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daisuke OGASAWARA (La Jolla, California); Taka-Aki ICHU (La Jolla, California); Jonathan HULCE (La Jolla, California); Benjamin F. CRAVATT (La Jolla, California) |
| ABSTRACT | Provided herein are compounds and compositions useful as modulators of ABHD12. Furthermore, the subject compounds and compositions are useful as immunotherapies in treating, for instance, cancer or infectious diseases. |
| FILED | Tuesday, May 14, 2019 |
| APPL NO | 17/055081 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/04 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) Original (OR) Class C07D 471/04 (20130101) C07D 471/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221796 | TENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Forge Therapeutics, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min TENG (San Diego, California); Baskar NAMMALWAR (San Diego, California); Xiaoming LI (San Diego, California); Christian PEREZ (San Diego, California); Ian YULE (Abingdon, United Kingdom); Adele FAULKNER (Abingdon, United Kingdom); Holly ATTON (Abingdon, United Kingdom); Alastair PARKES (Abingdon, United Kingdom); Serge CONVERS-REIGNIER (Abingdon, United Kingdom); Michelle SOUTHEY (Abingdon, United Kingdom); David T. PUERTA (San Diego, California) |
| ABSTRACT | Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/205750 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 239/54 (20130101) C07D 401/06 (20130101) C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 403/10 (20130101) C07D 403/14 (20130101) Original (OR) Class C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 409/12 (20130101) C07D 413/14 (20130101) C07D 487/04 (20130101) C07D 491/048 (20130101) C07D 491/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221805 | HAWKINS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William HAWKINS (St. Louis, Missouri); Robert MACH (St. Louis, Missouri); Dirk SPITZER (St. Louis, Missouri); Suwanna VANGVERAVONG (St. Louis, Missouri); Brian VAN TINE (St. Louis, Missouri) |
| ABSTRACT | Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC50 value below 5 μM against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo, and led to 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196286 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/517 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 451/14 (20130101) Original (OR) Class C07D 471/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221826 | Bradner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | James E. Bradner (Weston, Massachusetts); Jun Qi (Sharon, Massachusetts); Minoru Tanaka (Boston, Massachusetts); Justin M. Roberts (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V), and (VI). Some bromodomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 17/122258 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/551 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/16 (20180101) Heterocyclic Compounds C07D 519/00 (20130101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221835 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Atlanta, Georgia) |
| ASSIGNEE(S) | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Atlanta, Georgia) |
| INVENTOR(S) | Binghe WANG (Marietta, Georgia); Xingyue Jl (Atlanta, Georgia); Zhixiang PAN (Atlanta, Georgia) |
| ABSTRACT | Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described. |
| FILED | Wednesday, November 15, 2017 |
| APPL NO | 16/487402 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Acyclic or Carbocyclic Compounds C07C 49/573 (20130101) C07C 69/757 (20130101) C07C 233/58 (20130101) Heterocyclic Compounds C07D 295/192 (20130101) C07D 487/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/1804 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/20 (20130101) C07H 15/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221843 | PELLECCHIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maurizio PELLECCHIA (San Diego, California); Luca GAMBINI (Riverside, California); Ahmed SALEM (Riverside, California); Alexander ARONSON (Riverside, California) |
| ABSTRACT | The methods and compositions of the disclosure provide for novel therapeutic compounds to treat obesity and aspects related thereto. Embodiments of the disclosure relate to oligonucleotide therapeutic (ONT) agents targeting miR-22 miRNA for the treatment of human obesity and related cardiometabolic disorders. Accordingly, aspects of the disclosure relate to modified nucleic acids, including locked nucleic acids, ethylene-bridged nucleotides, peptide nucleic acids, phosphorodiamidate morpholino oligonucleotides, and/or a 5′(E)-vinyl-phosphonate modification. |
| FILED | Friday, June 07, 2019 |
| APPL NO | 17/058519 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221850 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Holland Cheng (Oakland, California); Chun Chieh Chen (Oakland, California); Mohammad Ali Baikoghli (Oakland, California); Marie Stark (Oakland, California) |
| ABSTRACT | A Hepatitis E virus (HEV)-based virus like nanoparticle (HEVNP) made with a modified capsid protein containing at least a portion of open reading frame 2 (ORF2) protein conjugated with gold nanocluster is provided. Also provided are methods of targeted delivery of a nucleic acid using the HEVNP. |
| FILED | Thursday, June 06, 2019 |
| APPL NO | 15/734877 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/62 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/28122 (20130101) C12N 2770/28123 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221858 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabsang Lee (Ellicott City, Maryland); Hyesoo Kim (Baltimore, Maryland); InYoung Choi (Baltimore, Maryland); HoTae Lim (Baltimore, Maryland); Alex V. Huynh (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of stem cells. More specifically, the present invention provides compositions and methods for using optogenetics to sustain the pluripotency of stem cells. In one embodiment, a vector comprises a nucleotide sequencing encoding a fusion protein comprising the intracellular domain of fibroblast growth factor 1 receptor (FGFR1) and a photoactivatable domain. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152220 |
| CURRENT CPC | Peptides C07K 14/71 (20130101) C07K 14/405 (20130101) Original (OR) Class C07K 2319/02 (20130101) Apparatus for Enzymology or Microbiology; C12M 31/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0696 (20130101) C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221872 | Ahmed et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafi Ahmed (Atlanta, Georgia); Carl Davis (Atlanta, Georgia); Erica Ollmann Saphire (Solana Beach, California) |
| ABSTRACT | This disclosure relates to antibodies and antigen binding fragments that specifically bind Ebola virus particles. In certain embodiments, the antibodies and fragments are capable of treating or preventing an Ebola viral infection. In certain embodiments, the antibodies and antigen binding fragments are also contemplated for diagnostic methods and compositions related thereto. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196418 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/71 (20130101) C07K 2317/72 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/524 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221873 | Marasco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Burnham Institute for Medical Research (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne A. Marasco (Wellesley, Massachusetts); Jianhua Sui (Boston, Massachusetts); Robert C. Liddington (La Jolla, California) |
| ABSTRACT | Disclosed are antibodies that bind to the stem region of influenza hemagglutinin in the neutral pH conformation, hemagglutinin epitopes in the stem region, and methods of making and using both. |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/020255 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) Peptides C07K 14/005 (20130101) C07K 16/1018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221874 | SHOEMAKER |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF TUFTS COLLEGE (Medford, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF TUFTS COLLEGE (MEDFORD, Massachusetts) |
| INVENTOR(S) | CHARLES B. SHOEMAKER (MEDFORD, Massachusetts) |
| ABSTRACT | Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent, methods, compositions and kits having a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes at least one or a plurality of disease agents that are toxins, for example at least one of a Botulinum toxin or an Anthrax toxin. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/221177 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/1278 (20130101) C07K 16/1282 (20130101) Original (OR) Class Enzymes C12Y 304/24069 (20130101) C12Y 304/24083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221904 | ZURAWSKI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| ASSIGNEE(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| INVENTOR(S) | Gerard ZURAWSKI (Midlothian, Texas); Jacques F. Banchereau (Montclair, New Jersey); Anne-Laure FLAMAR (New York, New York); Yves Levy (, None); Monica Montes (Dallas, Texas) |
| ABSTRACT | The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/301118 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/385 (20130101) A61K 2039/6056 (20130101) Peptides C07K 14/005 (20130101) C07K 16/00 (20130101) C07K 16/2878 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221906 | MARASCO |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne A. MARASCO (Wellesley, Massachusetts) |
| ABSTRACT | The present invention provides chimeric antigen receptor cells specific for carbonic anhydrase IX (CAIX) and methods of using same for treatment of CAIX expressing cancers such as renal cell carcinoma. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/129369 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/2013 (20130101) A61K 39/0011 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/40 (20130101) C07K 2317/51 (20130101) C07K 2317/60 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 5/0638 (20130101) C12N 9/88 (20130101) C12N 2510/00 (20130101) Enzymes C12Y 402/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221916 | Tsimikas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sotirios Tsimikas (San Diego, California); Joseph L. Witztum (San Diego, California); Xuchu Que (San Diego, California) |
| ABSTRACT | The disclosure provides for methods and treatments of ischemic injury, reperfusion injury, stroke and myocardial infarctions by administering within minutes to hours an antibody or antibody fragment that bind to and inhibits the biological activity of OxPL in an affected tissue. |
| FILED | Friday, October 26, 2018 |
| APPL NO | 16/759331 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/39583 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 9/10 (20180101) Peptides C07K 16/44 (20130101) Original (OR) Class C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221961 | Turng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lih-Sheng Turng (Madison, Wisconsin); Yiyang XU (Madison, Wisconsin); Dongfang Wang (Madison, Wisconsin) |
| ABSTRACT | Methods of making polytetrafluoroethylene (PTFE)/polymer composites are disclosed herein. The products can be used in the field of bio- and medical applications, such as for use in artificial blood vessels, vascular grafts, cardiovascular and soft tissue patches, facial implants, surgical sutures, and endovascular prosthesis, and for any products known in the aerospace, electronics, fabrics, filtration, industrial and sealant arts. |
| FILED | Thursday, January 16, 2020 |
| APPL NO | 16/744497 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/618 (20130101) A61K 47/32 (20130101) A61K 47/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/18 (20130101) A61L 27/26 (20130101) A61L 27/48 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/507 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/0012 (20190201) B29C 48/022 (20190201) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2027/18 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/005 (20130101) Original (OR) Class C08J 9/283 (20130101) C08J 2327/18 (20130101) C08J 2467/04 (20130101) C08J 2475/04 (20130101) Compositions of Macromolecular Compounds C08L 27/18 (20130101) C08L 2201/06 (20130101) C08L 2203/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222104 | MARTIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SAINT LOUIS UNIVERSITY (St. Louis, Missouri) |
| ASSIGNEE(S) | Saint Louis University (St. Louis, Missouri) |
| INVENTOR(S) | Robert Scott MARTIN (Kirkwood, Missouri); Chengpeng CHEN (St. Louis, Missouri); Scott Allen SELL (St. Louis, Missouri) |
| ABSTRACT | Disclosed are fluidic devices and methods for preparing fluidic devices. More particularly, disclosed are fluidic devices having fiber scaffolds and methods for their preparation. Also disclosed are methods for culturing cells using the fluidic devices having fiber scaffolds. |
| FILED | Tuesday, April 18, 2017 |
| APPL NO | 16/094086 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/14 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0985 (20130101) D01D 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222123 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Su-Chun Zhang (Waunakee, Wisconsin); Xiang Li (Pacifica, California) |
| ABSTRACT | Methods and compositions for expanding dopaminergic neuron progenitor cells are described herein that include use of compositions and culture media that have at least the following components: an FGF, an agonist of SHH signaling, an agonist of canonical Wnt signaling, and Wnt-C59. The methods include contacting dopaminergic neuron progenitor cells with a culture medium comprising an FGF, an agonist of SHH signaling, an agonist of canonical Wnt signaling, and Wnt-C59, to generate an expanded dopaminergic neuron progenitor cell population. |
| FILED | Wednesday, December 09, 2020 |
| APPL NO | 17/117062 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0031 (20130101) C12N 5/0056 (20130101) C12N 5/0619 (20130101) Original (OR) Class C12N 2500/90 (20130101) C12N 2500/98 (20130101) C12N 2501/41 (20130101) C12N 2501/119 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222125 | Shah |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dhvanit I. Shah (Malden, Massachusetts) |
| ABSTRACT | In some aspects and embodiments, the invention provides methods for making hematopoietic stem cells, including for HSCT. The method comprises providing a cell population comprising hemogenic endothelial (HE) or endothelial cells, and increasing activity or expression of DNA (cytosine-5-)-methyltransferase 3 beta (Dnmt3b) and/or GTPase IMAP Family Member 6 (Gimap6) in the HE and/or endothelial cells under conditions sufficient for stimulating formation of HSCs. |
| FILED | Friday, June 07, 2019 |
| APPL NO | 16/972212 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 2501/999 (20130101) C12N 2506/28 (20130101) C12N 2527/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222128 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher S. CHEN (Newton, Massachusetts); Sangeeta N. BHATIA (Lexington, Massachusetts); Arnav CHHABRA (Cambridge, Massachusetts); Amanda CHEN (East Cambridge, Massachusetts); Hyun Ho SONG (Long Island City, New York) |
| ABSTRACT | Inducible engineered tissue constructs comprising at least one cell population comprising a genetic construct are provided. Methods of making and using said constructs are also provided. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 16/953002 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3886 (20130101) A61L 27/3895 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0656 (20130101) C12N 5/0671 (20130101) Original (OR) Class C12N 9/6472 (20130101) C12N 2502/1323 (20130101) C12N 2513/00 (20130101) Enzymes C12Y 304/22062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222139 | Rex et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tonia S. Rex (Nashville, Tennessee); Jon R. Backstrom (Nashville, Tennessee) |
| ABSTRACT | A nucleic acid molecule is uniquely designed and encodes an entire CRISPRi or CRISPRa system, while being sized for packaging within a single adeno-associated virus (AAV) vector. Examples of the nucleic acid molecule include about 4600 to 4700 base pairs. Examples of the nucleic acid molecule can include a nucleotide encoding a Cas polypeptide; a nucleotide encoding a repressor or an activator domain attached to the nucleotide encoding the Cas polypeptide via a linker; a first promoter operably connected to the nucleotide encoding the repressor or activator domain or the nucleotide encoding the Cas polypeptide; a nucleotide encoding an alpha-helical connecting the nucleotide encoding the Cas polypeptide to a nuclear localization signal (NLS); and a second promoter operably connected to a guide RNA (gRNA). |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150562 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2750/14143 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222147 | PTACIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SYNTHORX, INC. (La Jolla, California); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerod PTACIN (La Jolla, California); Carolina CAFFARO (La Jolla, California); Hans AERNI (La Jolla, California); Yorke ZHANG (La Jolla, California); Emil C. FISCHER (La Jolla, California); Aaron W. FELDMAN (La Jolla, California); Vivian T. DIEN (La Jolla, California); Floyd E. ROMESBERG (La Jolla, California) |
| ABSTRACT | Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196151 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/90 (20130101) C12N 15/113 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222152 | Pattenden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samantha Gail Pattenden (Mebane, North Carolina); Paul Alexander Dayton (Carrboro, North Carolina); Ian Jonathan Davis (Chapel Hill, North Carolina); Austin Louis Quimby (Chapel Hill, North Carolina) |
| ABSTRACT | Methods of extracting chromatin from tissue, such as formalin fixed, paraffin embedded (FFPE) tissue, are provided. The methods are rapid, simple, and preserve the chromatin signature. The methods can include, for example, removal of the tissue from the paraffin, enzymatic digestion of the extracellular matrix, and exposure to ultrasound energy, optionally in the presence of a cavitation enhancement agent, such as microbubbles, nanobubbles, and/or phase-change nanodroplets. The methods can also include a mechanical tissue dissociation step. The methods provide chromatin fragments that are free of enzyme bias from fragmentation by enzymes such as micrococcal nuclease (MNase) and that are of optimal size for further quantification and/or identification. Kits for extracting chromatin from tissue are also provided. |
| FILED | Friday, May 10, 2019 |
| APPL NO | 17/054383 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222164 | CHOUDHARY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Basudeb MAJI (Cambridge, Massachusetts); Bernd ZETSCHE (Cambridge, Massachusetts); Feng ZHANG (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure includes non-naturally occurring or engineered DNA- or RNA-guided nuclease systems, comprising guide-binding adaptors each associated with at least one destabilization domain (DD), along with compositions, systems and complexes involving such systems, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses therefor. |
| FILED | Thursday, June 29, 2017 |
| APPL NO | 16/314375 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222167 | Monani et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Umrao Monani (Oradell, New Jersey); Maoxue Tang (New York, New York) |
| ABSTRACT | The present invention relates to a novel antisense transcript to the human SLC2A1 (Glut1) gene, variants and fragments thereof. This antisense transcript can be used to modulate Glut1 expression and serve to restore Glut1, and as a therapeutic for treating or preventing Glut 1 deficiency syndrome, or other Glut1 related conditions including certain cancers, diabetes, Alzheimer's disease, and retinitis pigmentosa. |
| FILED | Friday, October 12, 2018 |
| APPL NO | 16/755484 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222168 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeannie T. Lee (Boston, Massachusetts); Lieselot Carrette (Beernem, Belgium) |
| ABSTRACT | Methods for reactivating genes on the inactive X chromosome that include administering an inhibitor of XIST RNA and an inhibitor of an Xist-interacting protein, e.g., a chromatin-modifying protein, e.g., a small molecule or an inhibitory nucleic acid (such as a small inhibitory RNA (siRNAs) or antisense oligonucleotide (ASO)) that targets XIST RNA and/or a gene encoding an Xist-interacting protein, e.g., a chromatin-modifying protein. |
| FILED | Monday, December 03, 2018 |
| APPL NO | 16/769078 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/712 (20130101) A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/113 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/341 (20130101) C12N 2310/346 (20130101) C12N 2310/3231 (20130101) C12N 2320/31 (20130101) C12N 2320/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222170 | NIMJEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina); Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Shahid M. NIMJEE (Columbus, Ohio); Bruce SULLENGER (Durham, North Carolina); George A. PITOC (Durham, North Carolina); Juliana LAYZER (Durham, North Carolina) |
| ABSTRACT | Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/146147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 31/7115 (20130101) A61K 45/06 (20130101) A61K 47/60 (20170801) A61K 47/64 (20170801) A61K 47/554 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 15/115 (20130101) C12N 2310/16 (20130101) C12N 2310/113 (20130101) C12N 2310/317 (20130101) C12N 2310/3183 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222172 | Monga et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Satdarshan Monga (Wexford, Pennsylvania); Kari Nejak-Bowen (Wexford, Pennsylvania) |
| ABSTRACT | A method of treating porphyria in a patient is provided comprising knocking down or reducing expression or activity of β-catenin in the patient, e.g., in the liver of a patient, to an extent effective to treat porphyria in a patient. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/194706 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/444 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222175 | Rogers |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Faye A. Rogers (Norwalk, Connecticut) |
| ABSTRACT | Disclosed herein are methods and agents for the treatment of cancer using p53-independent apoptosis to reduce the number of cancer cells that have an amplified HER2 gene, such as p53-depleted or p53-mutated cancer cells that have an amplified HER2 gene. Also disclosed herein are methods and agents for the treatment of HER2-positive cancer in individuals with Li-Fraumeni Syndrome. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/160050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6937 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222180 | VALDIVIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Raphael VALDIVIA (Durham, North Carolina); Per MALKUS (Durham, North Carolina); Lauren DAVEY (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides methods and systems for genetically altering and screening Akkermansia bacteria, including Akkermansia muciniphila. The methods also provide genetically altered bacteria, libraries of genetically altered bacteria and use of such bacteria for treatment of diseases. |
| FILED | Wednesday, May 15, 2019 |
| APPL NO | 17/055478 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/74 (20130101) Original (OR) Class C12N 15/1079 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222193 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Prashant G. Mali (La Jolla, California); Luhan Yang (Somerville, Massachusetts) |
| ABSTRACT | A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186139 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/01 (20130101) C12N 15/10 (20130101) C12N 15/63 (20130101) C12N 15/81 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 15/87 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) C12N 15/1024 (20130101) C12N 15/8201 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) C12N 2810/55 (20130101) Enzymes C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222194 | ZOLOTUKHIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Sergei ZOLOTUKHIN (Gainesville, Florida); Oleksandr KONDRATOV (Gainesville, Florida) |
| ABSTRACT | Provided herein are methods and compositions useful in the production of recombinant AAV (rAAV) in insect cells. In some embodiments, methods and compositions include the use of modified Kozak sequences to express AAV VP1 proteins in amounts that are useful for producing infective rAAV particles. |
| FILED | Sunday, April 16, 2017 |
| APPL NO | 16/093586 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2710/14144 (20130101) C12N 2750/14143 (20130101) C12N 2800/50 (20130101) C12N 2840/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222195 | PICKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louis PICKER (Portland, Oregon); Klaus FRÜH (Portland, Oregon); Scott G. Hansen (Portland, Oregon) |
| ABSTRACT | Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of the heterologous antigen. The CMV vector may comprise a deleterious mutation in the US11 glycoprotein or a homolog thereof. |
| FILED | Tuesday, July 21, 2020 |
| APPL NO | 16/934495 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222196 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Guangping Gao (Westborough, Massachusetts); Jun Xie (Shrewsbury, Massachusetts) |
| ABSTRACT | In some aspects the disclosure relates to recombinant adeno-associated vims (rAAV) vectors and rAAVs (e.g., viral particles) engineered to express a transgene comprising an inhibitory nucleic acid (e.g., an artificial miRNA, amiRNA) having a pri-miRNA scaffold and a guide strand that targets a human target gene. |
| FILED | Wednesday, May 15, 2019 |
| APPL NO | 17/054794 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2320/32 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222199 | ABBADI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dounia ABBADI (New York, New York); Robert J. SCHNEIDER (New York, New York) |
| ABSTRACT | The present application relates to an adeno-associated viral (AAV) vector, comprising a muscle cell-specific promoter and a nucleic acid molecule encoding an AU-rich mRNA binding factor 1 (AUF1) protein or a functional fragment thereof, where the nucleic acid molecule is heterologous to and operatively coupled to the muscle cell-specific promoter. Also disclosed are compositions comprising the AAV vector, as well as methods of promoting muscle regeneration in injured muscle, a method of treating degenerative skeletal muscle loss in a subject, methods of preventing traumatic muscle injury in a subject such as Duchenne Muscular Dystrophy, methods of treating traumatic muscle injury in a subject, and methods of treating muscle loss due to aging in a subject. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152463 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222204 | Rose et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | John C. Rose (Seattle, Washington); Dustin James Maly (Seattle, Washington); Douglas Fowler (Seattle, Washington); Nicholas Popp (Seattle, Washington) |
| ABSTRACT | The disclosure provides compositions and methods for suppressing off-target editing guide RNA-nuclease complexes. The disclosed strategies incorporate use of catalytically inactive truncated guide RNA/nuclease complexes to shield off-target editing. In some embodiments, the disclosure provides a method of inhibiting off-target cleavage of DNA by a first guide RNA-endonuclease complex by contacting the DNA with a second guide RNA-endonuclease complex that comprises a second guide RNA corresponding to the off-target site but with a recognition sequence of 16 or fewer nucleotides. In another aspect, the disclosure provides a method for preventing cleavage of DNA after editing and subsequent homology-directed repair (HDR) by contacting the repaired DNA with a guide RNA-endonuclease complex that comprises a guide RNA with a guide RNA corresponding to the repaired sequence but with a recognition sequence of 16 or fewer nucleotides. Additional methods, compositions, and kits are also provided. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/144944 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222245 | Leppert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LineaGen, Inc. (Salt Lake City, Utah); University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Leppert (Salt Lake City, Utah); William McMahon (Salt Lake City, Utah); Nori Matsunami (Salt Lake City, Utah); Michael S. Paul (Salt Lake City, Utah); Alex S. Lindell (Salt Lake City, Utah) |
| ABSTRACT | The present disclosure relates to the identification of a subject that is affected with, or predisposed to, autism or to one or more autism spectrum disorders (ASD). The present disclosure includes methods related to the association of certain genetic markers with autism and/or ASD. More particularly, the present disclosure is related to methods and diagnostic tests for diagnosing or predicting ASD in an individual. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/099195 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/172 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223177 | RAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Govind RAO (Ellicott City, Maryland); Yordan KOSTOV (Ellicott City, Maryland); Mustafa AL-ADHAMI (Silver Spring, Maryland); Chandrasekhar GURRAMKONDA (Baltimore, Maryland) |
| ABSTRACT | A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/156915 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 2300/0867 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2304/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/645 (20130101) G01N 21/6428 (20130101) Original (OR) Class G01N 2021/0112 (20130101) G01N 2333/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223230 | Hu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guofu Hu (Wellesley, Massachusetts) |
| ABSTRACT | Provided herein are compositions containing neamine, or a composition containing an agent that possesses one or more activities of neamine, and the research, diagnostic and therapeutic uses of such compounds, such as for the treatment of cancer. |
| FILED | Thursday, September 25, 2014 |
| APPL NO | 14/496721 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/7036 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/118 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class G01N 33/5064 (20130101) G01N 33/57415 (20130101) G01N 33/57434 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223233 | Kirichok et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yuriy Kirichok (Lafayette, California); Francesca Fieni (San Francisco, California) |
| ABSTRACT | Disclosed herein is a newly discovered mitochondrial inner membrane nonspecific monovalent cation conductance. Methods of measuring the conductance are provided, including by patch clamp electrophysiology techniques, as well as methods of identifying inhibitors of the conductance. Inhibitors of the conductance are provided, as well as methods of using such inhibitors in the treatment of disease. |
| FILED | Tuesday, May 21, 2019 |
| APPL NO | 15/733874 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/4965 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 33/5076 (20130101) Original (OR) Class G01N 2015/0038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223240 | STOJANOVIC et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Milan STOJANOVIC (Ridgewood, New Jersey); Anne Milasincic ANDREWS (Los Angeles, California); Kyungae YANG (New York, New York); Paul S. WEISS (Los Angeles, California); Nako NAKATSUKA (Adliswill, Switzerland) |
| ABSTRACT | Devices for detecting at least one target molecule in a sample are provided. The devices comprise a field-effect transistor and an aptamer attached to the field-effect transistor. The aptamer comprises a capture region and a stem region, wherein the target molecule can selectively bind to the capture region of the aptamer. The stem region can change a conformation of the aptamer when the capture region binds to the target molecule. Techniques for detecting a target molecule using such devices are also provided. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175190 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4145 (20130101) G01N 27/4148 (20130101) G01N 33/6818 (20130101) G01N 33/54373 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223248 | TURTLE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cameron J. TURTLE (Seattle, Washington); Kevin A. HAY (Vancouver, Canada); Alexandre Vinaud HIRAYAMA (Seattle, Washington); Jordan GAUTHIER (Seattle, Washington) |
| ABSTRACT | The instant disclosure provides biomarkers and methods for identifying subjects at risk of relapse or suitable for allogeneic hematopoietic stem cell transplant after adoptive immunotherapy to guide preemptive intervention, modified therapy, or the like. Exemplary biomarkers include pre-lymphodepletion levels of serum lactate dehydrogenase (LDH), pre-lymphodepletion levels of platelets, levels of MCP-1, levels of IL-17, and pre-treatment regimen disease pathology. Based on the determined risk-relapse profile, an at-risk subject may be treated with pre-emptive therapy, while a subject not at risk for relapse may not receive further treatment, or may receive an allogeneic hematopoietic stem cell transplant. Also provided are methods for treating a hematological malignancy, wherein certain embodiments of the methods comprise adoptive cell therapy in the context of BTK-inhibitor therapy and/or BTK-inhibitor therapy in the context of adoptive cell therapy. Also provided are methods for treating follicular lymphoma (FL). |
| FILED | Friday, May 31, 2019 |
| APPL NO | 15/734205 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57426 (20130101) Original (OR) Class G01N 33/57484 (20130101) G01N 2333/904 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223250 | Condeelis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John S. Condeelis (Bronx, New York); Allison S. Harney (Bronx, New York) |
| ABSTRACT | Disclosed are kits and methods for detecting the presence of tumor sites that are active in tumor cell dissemination and uses thereof for determining the risk of tumor cells undergoing hematogenous metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, for determining a course of treatment for a localized tumor, and for identifying agents to treat or prevent hematogenous metastasis. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209670 |
| CURRENT CPC | Peptides C07K 16/22 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/57415 (20130101) G01N 33/57484 (20130101) Original (OR) Class G01N 2800/50 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223255 | Weinberger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GenNext Technologies, Inc. (Montara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scot Randy Weinberger (Montara, California); Joshua S. Sharp (Oxford, Mississippi); Sandeep Misra (Oxford, Mississippi) |
| ABSTRACT | The three-dimensional structural analysis of pharmaceutical and/or biological molecules is performed by the reaction of OH radicals on the surfaces of the molecules of interest. Quantitation and/or completeness of the OH radicals are optionally measured using buffers intrinsic to the sample solutions as internal standards. Measurements of the reactions of these buffers with OH radicals provide an internal standard while avoiding the use of prior art internal standards that can have unwanted effects on the three-dimensional structures of interest. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193913 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/33 (20130101) G01N 21/6428 (20130101) G01N 33/6803 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223257 | JOHNSTON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Albert JOHNSTON (Tempe, Arizona); Phillip STAFFORD (Phoenix, Arizona); Jian ZHANG (Peoria, Arizona); Luhui SHEN (Tempe, Arizona) |
| ABSTRACT | Disclosed herein are methods and systems for determining microsatellite instability. In some embodiments, the disclosed methods and systems are used for determining whether a cancer patient has high microsatellite instability (MSI-H). MSI-H patients have remarkably good responses to immunotherapy, such as checkpoint inhibitors immunotherapy. Therefore, the disclosed methods and systems can be used for identifying MSI-H and thus, patients as candidates for immunotherapy. In turn, the disclosed methods and systems can be used to predict responsiveness to immunotherapy. In some embodiments, the methods further include providing an immunotherapy to the MSI-H patient. Also disclosed are vaccines and compositions. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/249863 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/39 (20130101) A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) Original (OR) Class G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223263 | Horton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Shriners Hospitals for Children (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William A. Horton (Portland, Oregon); Gregory P. Lunstrum (Portland, Oregon); Ryan F. Coghlan (Portland, Oregon); Jon A. Oberdorf (Warren, Oregon) |
| ABSTRACT | The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215629 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/78 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/535 (20130101) G01N 33/566 (20130101) G01N 33/5029 (20130101) G01N 33/5044 (20130101) G01N 33/5082 (20130101) G01N 33/6887 (20130101) Original (OR) Class G01N 33/54306 (20130101) G01N 33/57488 (20130101) G01N 2800/10 (20130101) G01N 2800/52 (20130101) G01N 2800/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223265 | Stappenbeck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Thaddeus Stappenbeck (St. Louis, Missouri); Ta-Chiang Liu (St. Louis, Missouri); Kelli VanDussen (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Thaddeus Stappenbeck (St. Louis, Missouri); Ta-Chiang Liu (St. Louis, Missouri); Kelli VanDussen (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides methods for classifying a cell as abnormal based on HD5 protein detection as well as methods for predicting prognosis of a subject with Crohn's disease based on HD5 protein detection. |
| FILED | Thursday, April 27, 2017 |
| APPL NO | 16/097104 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223268 | Soto Jara et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Texas System (Austin, Texas); Amprion, Inc. (San Francisco, California) |
| ASSIGNEE(S) | Board of Regents of the University of Texas System (Austin, Texas); Amprion, Inc. (San Francisco, California) |
| INVENTOR(S) | Claudio Soto Jara (Friendswood, Texas); Mohammad Shahnawaz (Houston, Texas); Luis Concha (San Diego, California) |
| ABSTRACT | A method is provided for distinguishing between and/or diagnosing Parkinson's disease (PD) or multiple system atrophy (MSA) in a subject who is exhibiting symptoms associated with both PD and MSA. The method comprises: (A) contacting a biological sample obtained from the subject and comprising soluble, misfolded alpha-synuclein (αS) protein with a pre-incubation mixture comprising a monomeric αS substrate and an indicator to form an incubation mixture; (B) conducting an incubation cycle two or more times on the incubation mixture to form misfolded αS aggregates; (C) subjecting the incubation mixture to excitation and detecting via indicator fluorescence emission the misfolded αS aggregates; and (D) diagnosing the subject has having PD or MSA depending on the fluorescence emission intensity. In some aspects, the incubation cycles are conducted in the presence of a bead. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154431 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) G01N 23/06 (20130101) G01N 23/046 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2223/04 (20130101) G01N 2223/40 (20130101) G01N 2800/28 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223269 | Garcia-Jaramillo Rodriguez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon State University (Corvallis, Oregon); Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon); Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | Manuel Garcia-Jaramillo Rodriguez (Corvallis, Oregon); Gerd Bobe (Corvallis, Oregon); Claudia Susanne Maier (Corvallis, Oregon); Donald Bradley Jump (Philomath, Oregon); Armando Alcázar-Magaña (Apatzingan, Mexico); Dai-Trang Elizabeth Le (Portland, Oregon); Sanjiv Kaul (Portland, Oregon); Nabil J. Alkayed (West Linn, Oregon) |
| ABSTRACT | The present disclosure provides biomarkers for the detection of coronary artery disease. The biomarkers comprise oxylipins and the detection, identification, and quantification can provide a means to diagnose, prognose, and manage subject at risk for cardiovascular disease. Methods of also provided for the detection and quantification of the oxylipins, for treating, and for predicting the survival of a subject at high risk for coronary artery disease. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/156431 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223345 | PAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | JULLIE W. PAN (WEXFORD, Pennsylvania); CHAN-HONG MOON (PITTSBURGH, Pennsylvania); HOBY HETHERINGTON (WEXFORD, Pennsylvania) |
| ABSTRACT | A magnetic resonance imaging method includes performing an inversion pulse sequence using an MRI system, the inversion pulse sequence producing an inversion recovery period, and during the inversion recovery period: (i) performing a longitudinal T2 encoding pulse sequence using the MRI system; (ii) acquiring a post longitudinal T2 encoding pulse sequence image signal block immediately following the longitudinal T2 encoding pulse sequence using the MRI system; and (iii) acquiring an additional image signal block either before the longitudinal T2 encoding pulse sequence or following the acquiring of the post longitudinal T2 encoding pulse sequence image signal block using the MRI system. The method further include generating calculated image data based on at least the post longitudinal T2 encoding pulse sequence image signal block using a self-correcting normalization image combination scheme. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 15/734337 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/4822 (20130101) G01R 33/5602 (20130101) Original (OR) Class G01R 33/5616 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223414 | Harmon |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LightSpin Technologies Inc. (Endicott, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Harmon (Norfolk, Massachusetts) |
| ABSTRACT | A gamma-ray detector includes a plurality of modular one-dimensional arrays of monolithic detector sub-modules. Each monolithic detector sub-module includes a scintillator layer, a light-spreading layer, and a photodetector layer. The photodetector layer comprises a two-dimensional array of photodetectors that are arranged in columns and rows. A common printed circuit board is electrically coupled to the photodetectors of the monolithic detector sub-modules of a corresponding modular one-dimensional array. The photodetectors can be electrically coupled in a split-row configuration or in a checkerboard configuration. The photodetectors can also have a differential readout. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154217 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2985 (20130101) G01T 1/20182 (20200501) Original (OR) Class G01T 1/20186 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223532 | HILLMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Elizabeth M.C. HILLMAN (New York, New York); Venkatakaushik VOLETI (Cupertino, California) |
| ABSTRACT | In some embodiments of SCAPE imaging systems, a Powell lens is used to expand light from a light source into a sheet of illumination light. An optical system sweeps the sheet of illumination light through a sample, and forms an image at an intermediate image plane from detected return light. A camera captures images of the intermediate image plane. In some embodiments of SCAPE imaging systems, an optical system sweeps the sheet of illumination light through a sample, and forms an image at an intermediate image plane from detected return light. A camera captures images of the intermediate image plane. In the latter embodiments, the optical system is deliberately misaligned with respect to a true alignment position so that a significant portion of light that would be lost at the true alignment position will arrive at the camera. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/206778 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/22 (20130101) Original (OR) Class G02B 21/0032 (20130101) G02B 21/082 (20130101) G02B 21/361 (20130101) G02B 27/095 (20130101) G02B 27/0927 (20130101) G02B 27/0955 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210225385 | HEALY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric HEALY (Dublin, Ohio); Jordan L. VASKO (Strongsville, Ohio) |
| ABSTRACT | Auditory communication devices and related methods are described herein. An example auditory communication device can include a microphone configured to collect acoustic energy and convert the collected acoustic energy into an audio signal, a processor operably coupled to the microphone, and a memory operably coupled to the processor. The processor can be configured to receive the audio signal from the microphone, create a time-frequency (T-F) representation of the audio signal, classify each of a plurality of T-F units into one of N discrete categories, and attenuate the T-F representation of the audio signal. A respective level of attenuation for each of the T-F units is determined by its respective classification. The processor can be further configured to create a synthesized signal from the attenuated T-F representation of the audio signal. |
| FILED | Thursday, May 16, 2019 |
| APPL NO | 17/055430 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 21/0208 (20130101) Original (OR) Class G10L 21/0224 (20130101) G10L 21/0232 (20130101) G10L 25/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210219895 | Currano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luke J. Currano (Columbia, Maryland); Korine A. Ohiri (Laurel, Maryland); Leslie H. Hamilton (Silver Spring, Maryland); Matthew T. McGuire (Laurel, Maryland); Paul J. Biermann (Columbia, Maryland); Leah M. Strohsnitter (Baltimore, Maryland) |
| ABSTRACT | A muscle activity sensor includes a base textile, an electrode, and an interconnect. The base textile is configured to apply a compression force against a dermal surface of the user. The electrode is coupled to the base textile and includes a sensor layer including a conductive textile coupled to a dermal side of the base textile. The sensor layer is configured to receive electrical signals associated with muscle activity of the user. The electrode may also be configured to provide the electrical signals as an output signal. The interconnect may be coupled to the base textile over a distance from the electrode to an interconnect junction contact such that the interconnect moves with the base textile as the user moves. The interconnect may be further configured to deliver the output signal from the electrode to the interconnect junction contact. |
| FILED | Tuesday, November 10, 2020 |
| APPL NO | 17/093799 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/256 (20210101) Original (OR) Class A61B 5/271 (20210101) A61B 5/296 (20210101) A61B 5/313 (20210101) A61B 5/389 (20210101) A61B 5/6804 (20130101) A61B 5/6843 (20130101) A61B 2562/04 (20130101) A61B 2562/0209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220154 | Caldwell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Caldwell (Long Grove, Illinois); Matthew J. Major (Chicago, Illinois) |
| ABSTRACT | Pump systems for use in suspension of a prosthetic device from a residual limb and methods of suspending a prosthetic device from a residual limb are disclosed. The pump systems include a mechanically activated pump having a first compression member coupled to a second compression member, a diaphragm disposed between the first and second compression members, and coupling elements that engage and couple together the first and second compression members. The mechanically activated pump may be connected with an electrically activated pump, forming a hybrid pump system to provide vacuum engagement between a prosthetic device and a residual limb. |
| FILED | Wednesday, October 07, 2020 |
| APPL NO | 17/065167 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/70 (20130101) Original (OR) Class A61F 2/80 (20130101) A61F 2002/742 (20130101) A61F 2002/802 (20130101) A61F 2002/807 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220333 | MITRE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Elias Saul MITRE (Rockville, Maryland); Christopher Paul MORRIS (Frederick, Maryland); Alexander Francis FLYNN (Odenton, Maryland); Thomas B. NUTMAN (Chevy Chase, Maryland); Sasisekhar BENNURU (Rockville, Maryland) |
| ABSTRACT | The present disclosure is directed to methods for preventing or treating helminth (e.g., filarial) diseases in animals. The methods are accomplished by administering to the animal a therapeutically effective amount of an inhibitor of UDP-glucoronosyl transferase (UGT) or immunoglobulin I-set domain containing protein (Igl-DCP, also known as BMA-Lad-2). The inhibitors include those known to inhibit glucuronyltransferase enzyme activity as well as cell adhesion molecule inhibitors and antibodies specific for Igl-DCP and/or UGT. |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/273212 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/195 (20130101) A61K 31/4152 (20130101) Original (OR) Class A61K 31/4184 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/10 (20180101) Peptides C07K 16/40 (20130101) C07K 16/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220403 | METELITSA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Leonid S. METELITSA (Sugar Land, Texas); Daofeng Liu (Houston, Texas); Gianpietro Dotti (Houston, Texas); Andras Heczey (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Leonid S. METELITSA (Sugar Land, Texas); Daofeng Liu (Houston, Texas); Gianpietro Dotti (Houston, Texas); Andras Heczey (Houston, Texas) |
| ABSTRACT | The present invention regards methods and/or compositions related to Natural Killer T cells that are engineered to harbor an expression construct that encodes IL-2, IL-4, IL-7, and/or IL-15 and additionally or alternatively comprise a chimeric antigen receptor (CAR). In specific embodiments, the CAR is a CAR that targets the GD2 antigen, for example in neuroblastoma. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/071511 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) A61K 31/4545 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 39/00 (20130101) A61K 39/0011 (20130101) A61K 39/001171 (20180801) A61K 45/06 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) A61K 2039/55527 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) C12N 2500/02 (20130101) C12N 2501/2315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220434 | Wang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Rong Wang (San Francisco, California) |
| ABSTRACT | Provided are novel treatments for treating various conditions of insufficient blood flow or circulation. The novel inventions disclosed herein are based upon the discovery that increased Notch signaling in arterial vessels has a beneficial effect on blood flow or circulation and tissue regeneration as well as a reduction in tissue damage following arterial occlusion, constriction, or other reduction in blood flow. Increased Notch signaling in arteries promotes beneficial effects, including acute vessel dilation and/or arteriogenesis and collateral arterial growth, and improves recovery following ischemia or other reduced circulation condition. Also provided are medical devices for the delivery of Notch-activating agents to blood vessels. |
| FILED | Thursday, July 25, 2019 |
| APPL NO | 17/262460 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/19 (20130101) A61K 31/26 (20130101) A61K 31/517 (20130101) A61K 31/4741 (20130101) A61K 35/18 (20130101) A61K 35/19 (20130101) A61K 38/177 (20130101) Original (OR) Class A61K 47/6803 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220439 | Wagner |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEMS OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Amy Kathleen Wagner (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure relates to methods and compositions for treating traumatic brain injury (TBI) and TBI-associated impairments and improving outcome in subjects that have sustained traumatic brain injury comprising administering to the subject a sgp130 or an agent that promotes the binding of sgp130 and sIL-6R and/or reduces sIL-6R mediated trans-signaling. The present disclosure also relates to methods and kits for identifying a subject that is at risk of developing a TBI-associated impairment (e.g., headache, depression, cognitive deficits, and seizure) or monitoring the responsiveness to a treatment regimen for a TBI-associated impairment in the subject, using biomarkers (e.g., white blood cells indices (e.g., Neutrophil-Lymphocyte Ratio (NLR), absolute lymphocyte counts), sIL-6R, sgp130, IL-6, sgp130:sIL-6R ratio, sIL-2Ra, IL-2, sIL-2Ra:IL-2 ratio, TNFα, TNFRI, and TNFRI:TNFα ratio). |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135946 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1793 (20130101) Original (OR) Class A61K 47/6811 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/5412 (20130101) G01N 2333/7155 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220454 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Shuya Wang (Evanston, Illinois); Kacper Skakuj (Durham, North Carolina); Xiaoyi S. Hu (Acton, Massachusetts) |
| ABSTRACT | The disclosure is generally directed to immunostimulatory protein-core spherical nucleic acids (SNAs) comprising a protein core and a ratio of immunostimulatory and non-immunostimulatory strands, methods of making the immunostimulatory protein-core SNAs as well as their use. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 16/886712 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/804 (20180801) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220482 | Rao et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianghong Rao (Palo Alto, California); Liyang Cui (Sunnyvale, California) |
| ABSTRACT | Provided is a mitochondrial copper depleting strategy that exploits the potential vulnerability for this metabolic by cancer cells such as Triple Negative Breast Cancer cells. A nanoparticle is provided that comprises a self-reporting copper-depleting moiety (CDM) embedded in or on the matrix comprising a semi-conducting polymer and a phospholipid-polyethylene glycol (PEG). The positively charged copper-depleting complex targets mitochondria and deprives cytochrome c oxidase of its necessary copper co-factor. Inhibition of the electron transport chain complex IV compromises oxygen consumption and abrogates fatty acid oxidation, resulting in energy deficiency induced apoptosis of the targeted cancer cells. The copper-depleting nanoparticle can report the copper depleting status through multimodal optical signal changes while decreasing the copper level in tumors to inhibit tumor growth with low toxicity and significantly prolonged survival. |
| FILED | Wednesday, December 09, 2020 |
| APPL NO | 17/116357 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 31/4439 (20130101) A61K 47/6935 (20170801) Original (OR) Class A61K 49/222 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220823 | McFarland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirsty A. McFarland (Melrose, Massachusetts); Charles A. Lissandrello (Newtonville, Massachusetts); Andrew P. Magyar (Arlington, Massachusetts); Erin Rosenberger (Quincy, Massachusetts) |
| ABSTRACT | Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency. |
| FILED | Friday, October 12, 2018 |
| APPL NO | 16/755505 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50853 (20130101) Original (OR) Class B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 7/00 (20130101) B01L 2200/16 (20130101) B01L 2200/0689 (20130101) B01L 2300/044 (20130101) B01L 2300/168 (20130101) B01L 2300/0636 (20130101) Centrifuges B04B 3/00 (20130101) B04B 5/0414 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221497 | Dunn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Dunn (Trumbull, Connecticut); Joseph Nathan Hull (Azle, Texas) |
| ABSTRACT | A pitch beam movable by a pitch change shaft to adjust a pitch of at least one rotor blade of a rotor system via a pitch linkage includes a first surface having a generally planar configuration, a smooth second surface disposed opposite the first surface, and a sidewall extending between the first surface and the second surface. A pitch linkage connection point is disposed at the sidewall to which the pitch linkage is attachable. An interior is defined between the first surface and the second surface and an opening extends through the first and second surface at a rotational axis of the rotor system to which the pitch change shaft is attached. Movement of the pitch change shaft moves the pitch beam and adjusts the pitch of the at least one rotor blade via the pitch linkage attached at the pitch linkage connection point. |
| FILED | Monday, January 20, 2020 |
| APPL NO | 16/747199 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/59 (20130101) Original (OR) Class B64C 27/78 (20130101) B64C 27/82 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221676 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Arum Han (College Station, Texas); Jose A. Wippold (Bryan, Texas); Adrian R. Guzman (Houston, Texas); Can Huang (Houston, Texas); Dimitra Stratis-Cullum (Laurel, Maryland) |
| ABSTRACT | A microfluidic device includes a microfluidic channel formed in the microfluidic device and defined by a floor and a ceiling positioned vertically above the floor, wherein the microfluidic channel includes at least one fluid inlet configured to receive a fluid flow and at least one fluid outlet, and wherein at least one of the ceiling and the floor of the microfluidic channel is sloped relative to a horizontal plane. |
| FILED | Wednesday, October 07, 2020 |
| APPL NO | 17/065471 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00031 (20130101) Original (OR) Class B81C 2201/034 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/48 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221747 | SAMBASIVAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Applied Thin Films, Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sankar SAMBASIVAN (Chicago, Illinois); Vikram S. KAUL (Atlanta., Georgia); Francis R. CHAPMAN (Chicago, Illinois) |
| ABSTRACT | A material contains open pores in which the channels and pores that are internally coated with at least one layer of phosphorus-containing alumina. Such material is formed by infiltrating a porous material one or more times with a non-colloidal, low-viscosity liquid coating precursor, drying, and curing the coating precursor to form a phosphorus-containing alumina layer within pores of the material. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 17/073486 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/195 (20130101) C04B 35/522 (20130101) C04B 38/0054 (20130101) C04B 38/0096 (20130101) Original (OR) Class C04B 41/009 (20130101) C04B 41/85 (20130101) C04B 41/5092 (20130101) C04B 2235/3206 (20130101) C04B 2235/3208 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/125 (20130101) C23C 18/1216 (20130101) C23C 18/1229 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/288 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2300/514 (20130101) F05D 2300/6033 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/60 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/268 (20150115) Y10T 428/24997 (20150401) Y10T 428/249921 (20150401) Y10T 428/249967 (20150401) Y10T 428/249969 (20150401) Y10T 428/249978 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221872 | Ahmed et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafi Ahmed (Atlanta, Georgia); Carl Davis (Atlanta, Georgia); Erica Ollmann Saphire (Solana Beach, California) |
| ABSTRACT | This disclosure relates to antibodies and antigen binding fragments that specifically bind Ebola virus particles. In certain embodiments, the antibodies and fragments are capable of treating or preventing an Ebola viral infection. In certain embodiments, the antibodies and antigen binding fragments are also contemplated for diagnostic methods and compositions related thereto. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196418 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/71 (20130101) C07K 2317/72 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/524 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222139 | Rex et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tonia S. Rex (Nashville, Tennessee); Jon R. Backstrom (Nashville, Tennessee) |
| ABSTRACT | A nucleic acid molecule is uniquely designed and encodes an entire CRISPRi or CRISPRa system, while being sized for packaging within a single adeno-associated virus (AAV) vector. Examples of the nucleic acid molecule include about 4600 to 4700 base pairs. Examples of the nucleic acid molecule can include a nucleotide encoding a Cas polypeptide; a nucleotide encoding a repressor or an activator domain attached to the nucleotide encoding the Cas polypeptide via a linker; a first promoter operably connected to the nucleotide encoding the repressor or activator domain or the nucleotide encoding the Cas polypeptide; a nucleotide encoding an alpha-helical connecting the nucleotide encoding the Cas polypeptide to a nuclear localization signal (NLS); and a second promoter operably connected to a guide RNA (gRNA). |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150562 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2750/14143 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222155 | Barbieri et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Barbieri (Lindenhurst, New York); Farren Isaacs (Stamford, Connecticut) |
| ABSTRACT | Compositions and methods for gene editing are provided. The methods employ an oligo-based annealing mechanism that is rooted in the process of DNA replication rather than homologous recombination (HR). Oligo incorporation efficiencies are comparable and often exceed those of CRISPR/cas9 editing without the need for double strand breaks (DSBs). By relying on the multiplex annealing of oligos rather than DSBs the process is highly scalable across a genomic region of interest and can generate many scarless modifications of a chromosome simultaneously. Combinatorial genomic diversity can be generated across a population of cells in a single transformation event; genomic landscapes can be traversed through successive iterations of the process, and genome-wide changes can be massively parallelized and amplified through systematic strain mating. |
| FILED | Thursday, April 27, 2017 |
| APPL NO | 16/097091 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222626 | Nieto et al. |
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| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andy Nieto (Marina, California); Michael J. Walock (Bel Air, Maryland); Anindya Ghoshal (Phoenix, Maryland); Blake D. Barnett (Colombus, Ohio); Clara M. Mock (Belcamp, Maryland); Mark L. Graybeal (Conowingo, Maryland); Marc S. Pepi (Oxford, Pennsylvania); Muthuvel Murugan (Abingdon, Maryland) |
| ABSTRACT | A thermal barrier coating (TBC) material includes calcic-magnesia-alumina-silicates-resistant rare-earth (RE) oxide powder blended with yttria-stabilized zirconia (YSZ). The RE oxide powder may include any of gadolinium oxide, samarium oxide, ytterbium oxide and cerium oxide. The RE oxide powder may include gadolinium zirconate (GZO). |
| FILED | Wednesday, January 22, 2020 |
| APPL NO | 16/748971 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/28 (20130101) C23C 14/081 (20130101) C23C 16/403 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/24 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/31 (20130101) F05D 2230/90 (20130101) F05D 2300/603 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222920 | Pauzauskie et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Peter J. Pauzauskie (Seattle, Washington); Anupum Pant (Seattle, Washington); Xiaojing Xia (Seattle, Washington); Elena Dobretsova (Seattle, Washington); E. James Davis (Seattle, Washington); Alexander B. Bard (Seattle, Washington); Robert G. Felsted (Seattle, Washington) |
| ABSTRACT | An apparatus and method of indirectly cooling an optomechanical resonator, comprising impinging a laser on an optomechanical resonator attached to a substrate, wherein the optomechanical resonator comprises a cantilever, a cooling end of the cantilever, having a cooling end comprising a laser-induced cooling element, an attachment end of the cantilever, attached to a substrate, and wherein the laser has a peak wavelength in the near-infrared band. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152572 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 23/00 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1618 (20130101) H01S 3/1645 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222965 | Monacchio et al. |
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| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Monacchio (Windsor Locks, Connecticut); Eric Chrabascz (Longmeadow, Massachusetts); Luke J. Mayo (Coventry, Connecticut); John H. Whiton (South Windsor, Connecticut); Robert H. Dold (Monson, Massachusetts); Christopher Adriaan van Oss (Wethersfield, Connecticut); Usman Khan (South Windsor, Connecticut) |
| ABSTRACT | An outlet manifold is provided and includes an outlet portion having first and second sides and an inlet portion to which the outlet portion is fluidly coupled. The inlet portion has first and second sides corresponding to the first and second sides of the outlet portion. Each of the first and second sides of the inlet portion includes one or more tubular members connectable with corresponding tube joints and a mixing chamber fluidly interposed between each of the one or more tubular members and the outlet portion. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/136694 |
| CURRENT CPC | Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines F01N 13/06 (20130101) F01N 13/10 (20130101) F01N 13/107 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 9/0275 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223011 | Nguyen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huy P. Nguyen (Tucson, Arizona); Rob J. Fuentes (Tucson, Arizona); Michael Schmidt (Tucson, Arizona) |
| ABSTRACT | A kinetic energy vehicle (or warhead) has a divert thruster system and an attitude control system, both operatively coupled to receive pressurized gasses from a solid rocket motor that is operatively coupled to both systems. The attitude control system may have two pairs of attitude control thrusters, with one of the pairs diametrically opposed from the other pair, on opposite sides of an end (such as a rear end) of the vehicle. The attitude control thrusters all have radial and circumferential components to their thrust, and various combinations of the attitude control thrusters may be used to achieve desired roll, pitch, and/or yaw. |
| FILED | Wednesday, January 22, 2020 |
| APPL NO | 16/749324 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 10/663 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223230 | Hu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guofu Hu (Wellesley, Massachusetts) |
| ABSTRACT | Provided herein are compositions containing neamine, or a composition containing an agent that possesses one or more activities of neamine, and the research, diagnostic and therapeutic uses of such compounds, such as for the treatment of cancer. |
| FILED | Thursday, September 25, 2014 |
| APPL NO | 14/496721 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/7036 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/118 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class G01N 33/5064 (20130101) G01N 33/57415 (20130101) G01N 33/57434 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223235 | Mrksich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milan Mrksich (Hinsdale, Illinois); Patrick O'Kane (Chicago, Illinois) |
| ABSTRACT | Disclosed herein are methods of using an immobilized substrate, immobilized ligand, and a fusion protein of an enzyme for the substrate and a receptor for the ligand, where the immobilized substrate can react to form an immobilized product that has a different mass than the immobilized substrate, and using this transformation to indirectly determine the binding of the receptor and the ligand. These methods can be used for high-throughput screening for possible modulators (e.g., inhibitors or activators) of the ligand-receptor interaction. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/216307 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54306 (20130101) Original (OR) Class G01N 33/54353 (20130101) G01N 2333/47 (20130101) G01N 2333/98 (20130101) G01N 2560/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223250 | Condeelis et al. |
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| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John S. Condeelis (Bronx, New York); Allison S. Harney (Bronx, New York) |
| ABSTRACT | Disclosed are kits and methods for detecting the presence of tumor sites that are active in tumor cell dissemination and uses thereof for determining the risk of tumor cells undergoing hematogenous metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, for determining a course of treatment for a localized tumor, and for identifying agents to treat or prevent hematogenous metastasis. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209670 |
| CURRENT CPC | Peptides C07K 16/22 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/57415 (20130101) G01N 33/57484 (20130101) Original (OR) Class G01N 2800/50 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223252 | Dieterich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Daniela C. Dieterich (Pasadena, California); David Tirrell (Pasadena, California); Erin Schuman (Pasadena, California); Aaron J. Link (Pasadena, California) |
| ABSTRACT | The invention provides methods, reagents and systems for incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism. The incorporated non-natural amino acids contain reactive groups for further chemical reagents, which may serve as a “handle” to enrich the proteins or fragments thereof in a number of uses, such as proteomic analysis, imaging of diseased tissues/cells, etc. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/067028 |
| CURRENT CPC | Peptides C07K 7/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) Original (OR) Class G01N 33/5091 (20130101) G01N 33/6842 (20130101) G01N 33/6848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223288 | WEIKLE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Robert M. WEIKLE (Crozet, Virginia); Linli XIE (Charlottesville, Virginia); Michael E. CYBEREY (Charlottesville, Virginia); Souheil NADRI (Charlottesville, Virginia); Matthew F. BAUWENS (Chesapeake, Virginia); Arthur Weston LICHTENBERGER (Charlottesville, Virginia); Nicolas Scott BARKER (Charlottesville, Virginia) |
| ABSTRACT | A probe chip device and a method for fabricating a probe chip device with an integrated diode sensor are disclosed. In one example, a probe chip device includes a beam head element that includes at least one probe tip that is configured to electrically probe a device under test. The probe chip device further includes a diode sensor that is heterogeneously integrated on the beam head element and is proximally positioned to the at least one probe tip. |
| FILED | Friday, May 10, 2019 |
| APPL NO | 17/053930 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/015 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 1/06772 (20130101) Original (OR) Class G01R 3/00 (20130101) G01R 19/0046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223380 | Chi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia-Chi Samuel Chi (San Diego, California); Everly Yeo (San Diego, California); Max Kerber (San Diego, California); Randall B. Olsen (US, California) |
| ABSTRACT | A need exists for a method to do monopulse tracking with a single beam phased array antenna. With a monopulse tracker antenna, the satellite, or moving target, will have a beacon signal that the tracker can acquire. The beacon signal may be a preamble in the transmitted signal from the satellite. The monopulse tracker antennas are scanned over the volume, minimizing the error signal. When the error signal is minimal, the antenna is pointed in the direction of the satellite or moving target. Because the tracker needs to know direction offsets in both azimuth and elevation planes, error signals from both planes are needed. The monopulse tracker antenna maintains a radio frequency link to the beacon signal, causing the antenna to lock in the direction of the satellite when the error signal is minimized to zero. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 16/855002 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/32 (20130101) G01S 7/282 (20130101) G01S 7/2925 (20130101) G01S 13/426 (20130101) G01S 13/4463 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 25/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223868 | DANKOVICH |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louis J. DANKOVICH (Hyattsville, Maryland) |
| ABSTRACT | A gesture recognizing system for recognizing gestures includes a wearable band configured to wrap around an appendage of a user and a printed circuit board (PCB). The wearable band includes a first dielectric layer and a plurality of electrodes affixed on an outer surface of the first dielectric layer. When the first dielectric layer of the wearable band wraps around the appendage, each electrode is configured to form a capacitive sensor with skin of the user. The PCB includes a processor and a data collection hardware configured to collect data from capacitive sensors. The processor is configured to process the collected data and to recognize a gesture of the appendage of the user based on the processed data. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/000262 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/017 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210224213 | RAJ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swapna RAJ (Norwalk, Connecticut); Samantika S. SURY (Westford, Massachusetts); Kermin CHOFLEMING (Hudson, Massachusetts); Simon C. STEELY, JR. (Hudson, New Hampshire) |
| ABSTRACT | Examples include techniques for near data acceleration for a multi-core architecture. A near data processor included in a memory controller of a processor may access data maintained in a memory device coupled with the near data processor via one or more memory channels responsive to a work request to execute a kernel, an application or a loop routine using the accessed data to generate values. The near data processor provides an indication to the requestor of the work request that values have been generated. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/206961 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0815 (20130101) G06F 13/1668 (20130101) G06F 13/4027 (20130101) Original (OR) Class G06F 2212/1024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210224678 | WAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Noel WAN (Cambridge, Massachusetts); Jacques Johannes CAROLAN (Cambridge, Massachusetts); Tsung-Ju Lu (Cambridge, Massachusetts); Ian Robert Christen (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Noel WAN (Cambridge, Massachusetts); Jacques Johannes CAROLAN (Cambridge, Massachusetts); Tsung-Ju Lu (Cambridge, Massachusetts); Ian Robert Christen (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | A process is provided for the high-yield heterogeneous integration of ‘quantum micro-chiplets’ (QMCs, diamond waveguide arrays containing highly coherent color centers) with an aluminum nitride (AlN) photonic integrated circuit (PIC). As an example, the process is useful for the development of a 72-channel defect-free array of germanium-vacancy (GeV) and silicon-vacancy (SiV) color centers in a PIC. Photoluminescence spectroscopy reveals long-term stable and narrow average optical linewidths of 54 MHz (146 MHz) for GeV (SiV) emitters, close to the lifetime-limited linewidth of 32 MHz (93 MHz). Additionally, inhomogeneities in the individual qubits can be compensated in situ with integrated tuning of the optical frequencies over 100 GHz. The ability to assemble large numbers of nearly indistinguishable artificial atoms into phase-stable PICs is useful for development of multiplexed quantum repeaters and general-purpose quantum computers. |
| FILED | Monday, January 06, 2020 |
| APPL NO | 16/734727 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/005 (20130101) H01L 33/06 (20130101) H01L 33/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210225455 | Chowdhury et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | Zymergen Inc. (Emeryville, California) |
| INVENTOR(S) | Anupam Chowdhury (Oakland, California); Alexander Glennon Shearer (San Francisco, California); Stepan Tymoshenko (Emeryville, California); Michelle L. Wynn (Alameda, California); Erik Jedediah Dean (Lafayette, California) |
| ABSTRACT | Systems, methods and non-transitory computer-readable media identify a candidate biological sequence for enabling a function in a host cell. Embodiments access a predictive model that associates a plurality of biological sequences, such as enzymes, with one or more functions, such as reaction catalysis; predict, using the predictive model, that one or more candidate sequences of the plurality of biological sequences enable a desired function; and classify using a processor, candidate sequences that satisfy a confidence threshold as filtered candidate sequences. |
| FILED | Wednesday, August 14, 2019 |
| APPL NO | 17/267648 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) Original (OR) Class G16B 30/10 (20190201) G16B 40/20 (20190201) G16B 40/30 (20190201) G16B 50/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210225749 | Vaisband et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Boris Vaisband (Los Angeles, California); Subramanian S. Iyer (Los Angeles, California); Adeel A. Bajwa (Los Angeles, California) |
| ABSTRACT | A silicon interconnect fabric includes: (1) a substrate having a front side and a back side; (2) a front side patterned metal layer on the front side of the substrate; (3) a back side patterned metal layer on the back side of the substrate; (4) multiple conductive vias extending through the substrate and connecting the front side patterned metal layer and the back side patterned metal layer; and (5) multiple conductive posts connected to the back side patterned metal layer. |
| FILED | Thursday, November 01, 2018 |
| APPL NO | 16/760845 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/147 (20130101) H01L 23/473 (20130101) H01L 23/49811 (20130101) H01L 23/49827 (20130101) Original (OR) Class H01L 23/49866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226014 | Zakar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabiities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene S. Zakar (Bethesda, Maryland) |
| ABSTRACT | A maskless, patterned graphene film is produced through use of a tunable metal as a catalyst for graphene growth. The metal layer contains precisely defined textures that control the formation of the graphene film. Specifically, graphene growth can be controlled from F-LG (few layer graphene) down to 2-LG (2-layer graphene) and 1-LG (1-layer graphene). More than one texture can be created to form maskless patterns of graphene. Once the graphene layer(s) are grown, the film can be released from the metal and applied to any form and shape of rigid or flexible substrate for a variety of different applications where graphene cannot be normally grown directly. |
| FILED | Tuesday, January 21, 2020 |
| APPL NO | 16/748364 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/186 (20170801) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02527 (20130101) H01L 29/1606 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226078 | Derkacs |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SolAero Technologies Corp. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | SolAero Technologies Corp. (Albuquerque, New Mexico) |
| INVENTOR(S) | Daniel Derkacs (Albuquerque, New Mexico) |
| ABSTRACT | A multijunction solar cell including an upper first solar subcell having a first band gap and positioned for receiving an incoming light beam; a second solar subcell disposed below and adjacent to and lattice matched with said upper first solar subcell, and having a second band gap smaller than said first band gap; wherein a layer of light scattering elements is provided below and adjacent to the bottom solar subcell for redirecting the incoming light to be totally internally reflected within the solar cell. |
| FILED | Wednesday, January 22, 2020 |
| APPL NO | 16/749677 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0547 (20141201) H01L 31/0725 (20130101) Original (OR) Class H01L 31/0735 (20130101) H01L 31/1844 (20130101) H01L 31/02363 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226280 | Dieckmann |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TIAX LLC (Lexington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Dieckmann (Lexington, Massachusetts) |
| ABSTRACT | Provided is a thermal management device for an energy storage device with suitable architecture to accommodate any design of electrochemical ceil. A thermal management device may include a plurality of posts suitably shaped and sized to house a fluid feed tube and a fluid return tube in fluid communication with the fluid feed tube, a fluid supply manifold in fluid communication with the fluid feed tube, and a fluid return manifold in fluid communication with the fluid return tube. |
| FILED | Wednesday, May 16, 2018 |
| APPL NO | 17/055183 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/18 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/613 (20150401) H01M 10/6556 (20150401) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226357 | Jaworski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (, None) |
| INVENTOR(S) | Bradley S. Jaworski (Bedford, Massachusetts); Peter D. Morico (North Grafton, Massachusetts) |
| ABSTRACT | Systems and method are described for a terminal block that can include an insulating block that is composed of an electrically insulating material. The insulating structure can have a first via extending between a first and second opening in the insulating block. A second via can extend between a third and fourth opening in the insulating block. A distance between the first and second openings may be less than a distance between the third and fourth openings. A first electrical conducting element can extend between the first and second openings. A second electrical conducting element can extend between the third and fourth openings. The first and second electrical conducting elements can be separated from one another by a portion of the insulating block. |
| FILED | Tuesday, January 14, 2020 |
| APPL NO | 16/742822 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 9/16 (20130101) H01R 9/2408 (20130101) Original (OR) Class H01R 9/2416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226612 | Grout |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kevin Grout (Chandler, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Kevin Grout (Chandler, Arizona) |
| ABSTRACT | A system for generating an RFPWM signal comprises a delta sigma modulator having a plurality of outputs, a phase-locked loop comprising a plurality of phase quantization outputs, at least one multiplexer having a plurality of signal inputs, a plurality of selector inputs, and at least one output, the signal inputs communicatively connected to the phase quantization outputs of the phase-locked loop and the selector inputs electrically connected to the outputs of the delta sigma modulator, and a driver having an input communicatively connected to the output of the multiplexer and an output generating an RFPWM signal. A method of generating an RFPWM signal is also described. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154437 |
| CURRENT CPC | Pulse Technique H03K 3/012 (20130101) Original (OR) Class H03K 3/017 (20130101) H03K 19/20 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/08 (20130101) Coding; Decoding; Code Conversion in General H03M 3/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210227058 | Martinez-Heath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); AT and T Intellectual Property II, L.P. (Atlanta, Georgia); AT and T Global Network Services France SAS (Courbevoie, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miguel Martinez-Heath (East Windsor, New Jersey); Keylor Eng (Seattle, Washington); Aurelien Bruno (Colomars, France); Scott Sayers (Jackson, New Jersey) |
| ABSTRACT | Fault-tolerant signaling in a Long Term Evolution (LTE) network architecture is disclosed. A method can comprise initiating a primary signaling path to a signaling server device; in response to the initiating, establishing an alternate signaling path to a web application server device, wherein a call session is established over the primary signaling path; monitoring the primary signaling path for a session failure; and in response to the session failure, switching the call session from using the primary signaling path to using the alternate signaling path. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/201806 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/22 (20130101) H04L 65/104 (20130101) H04L 65/1016 (20130101) H04L 65/1066 (20130101) H04L 69/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210227384 | Harley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Michael Baab Harley (Annapolis, Maryland); Murali Tummala (Monterey, California); John Colin Mceachen (Carmel, California) |
| ABSTRACT | The invention relates to concealing information within error correction codes of adaptive rate wireless communication systems. In some embodiments, the invention includes selecting a modulation and coding scheme with a more robust error correction capacity than needed by current channel conditions; encoding a hidden message with a pre-shared key that is known by a covert transmitter and a covert receiver, and after a standard message is encoded by a transmitting station of the wireless communication systems, replacing codeword parity bits of codewords in the encoded standard message with the encoded hidden message at designated locations. Before a receiving station of the wireless communication systems decodes the encoded standard message, a covert receiver extracts the embedded hidden message from the encoded standard message, replaces bit values of the embedded hidden message with zero at the designated locations, and decodes the extracted hidden message with the pre-shared key. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/156425 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 13/353 (20130101) H03M 13/1102 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0002 (20130101) H04L 1/0054 (20130101) H04L 1/0061 (20130101) H04L 63/04 (20130101) Wireless Communication Networks H04W 12/037 (20210101) Original (OR) Class H04W 12/0431 (20210101) H04W 84/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210220823 | McFarland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirsty A. McFarland (Melrose, Massachusetts); Charles A. Lissandrello (Newtonville, Massachusetts); Andrew P. Magyar (Arlington, Massachusetts); Erin Rosenberger (Quincy, Massachusetts) |
| ABSTRACT | Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency. |
| FILED | Friday, October 12, 2018 |
| APPL NO | 16/755505 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50853 (20130101) Original (OR) Class B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 7/00 (20130101) B01L 2200/16 (20130101) B01L 2200/0689 (20130101) B01L 2300/044 (20130101) B01L 2300/168 (20130101) B01L 2300/0636 (20130101) Centrifuges B04B 3/00 (20130101) B04B 5/0414 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221945 | BECKHAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregg Tyler BECKHAM (Golden, Colorado); Nicholas A. RORRER (Golden, Colorado) |
| ABSTRACT | An aspect of the present disclosure is a composition that includes where R1 includes at least one of a saturated hydrocarbon and/or an unsaturated hydrocarbon, R3 includes at least one of a saturated hydrocarbon and/or an unsaturated hydrocarbon, A includes at least one of a saturated hydrocarbon or an unsaturated hydrocarbon, 1≤x≤1000, and 1≤y≤1000. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/205232 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/06 (20130101) C08F 222/06 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/52 (20130101) C08G 63/60 (20130101) C08G 63/91 (20130101) C08G 63/183 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 7/02 (20130101) Compositions of Macromolecular Compounds C08L 67/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222042 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sheng Dai (Knoxville, Tennessee); Carter W. Abney (Califon, New Jersey); Richard T. Mayes (Knoxville, Tennessee); Dmitriy Dolzhnikov (Oak Ridge, Tennessee); Huimin Luo (Knoxville, Tennessee) |
| ABSTRACT | A heat transfer (exchange) composition comprising a halide salt matrix having dispersed therein nanoparticles comprising elemental carbon in the absence of water and surfactants, wherein said halide is fluoride or chloride, wherein the halide salt may be an alkali halide salt (e.g., lithium fluoride, sodium fluoride, potassium fluoride, rubidium fluoride, sodium chloride, potassium chloride, rubidium chloride, and eutectic mixtures thereof) or an alkaline earth halide salt (e.g., fluoride or chloride salt of beryllium, magnesium, calcium, strontium, or barium), and wherein the nanoparticles comprising elemental carbon may be solid or hollow, and wherein the composition may further include nanoparticles comprising a fissile material (e.g., U, Th, or Pu) dispersed within the composition. Molten salt reactors (MSRs) containing these heat transfer compositions in coolant loops in thermal exchange with a reactor core, as well operation of such MSRs, are also described. |
| FILED | Thursday, July 19, 2018 |
| APPL NO | 16/039770 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/12 (20130101) Original (OR) Class Nuclear Reactors G21C 1/22 (20130101) G21C 3/44 (20130101) G21C 5/126 (20130101) G21C 15/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222208 | WYMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Charles E. WYMAN (Riverside, California); Abhishek S. PATRI (West Sacramento, California); Charles CAI (Riverside, California); Rajeev KUMAR (Ahmedabad, Gujarat, India); Priyanka SINGH (Riverside, California) |
| ABSTRACT | Described herein are microbial stimulating compounds that act as a surfactant to increase fermentation. Also described are methods for enhancing fermentation utilizing these compounds as well as methods for the producing the compounds from lignocellulosic biomass and biomass components during high temperature reactions with alcohols. The stimulating compounds can be produced from a variety of polysaccharides or sugars. |
| FILED | Thursday, June 27, 2019 |
| APPL NO | 17/256053 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 1/20 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222290 | lhala Gamaralalage et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chanaka Kapila Kumara lhala Gamaralalage (Oak Ridge, Tennessee); Jun Qu (Oak Ridge, Tennessee); Paul A. Menchhofer (Clinton, Tennessee) |
| ABSTRACT | A method for producing a structure containing an array of MWCNTs on a metal substrate, comprising: (i) subjecting a metal substrate to a surface oxidation process at a first elevated temperature in an oxygen-containing atmosphere and under a first reduced pressure; (ii) subjecting the metal substrate to a surface reduction process at a second elevated temperature in a reducing atmosphere and under a second reduced pressure of at least 0.01 atm and less than 1 atm to result in reduction of the surface of said metal substrate, wherein the reducing atmosphere contains hydrogen gas; (iii) subjecting the metal substrate to a third reduced pressure of no more than 0.1 atm; and (iv) contacting the metal substrate, while at the third reduced pressure and under an inert or reducing atmosphere, with an organic substance at a third elevated temperature for suitable time to produce the MWCNTs on the metal substrate. |
| FILED | Thursday, November 05, 2020 |
| APPL NO | 17/090216 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/168 (20170801) C01B 2202/06 (20130101) C01B 2202/08 (20130101) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 8/0278 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/52 (20130101) C23C 16/56 (20130101) C23C 16/0218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222532 | Sheng |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | Texas Tech University System (Lubbock, Texas) |
| INVENTOR(S) | James J. Sheng (Lubbock, Texas) |
| ABSTRACT | Methods for optimization of liquid oil production by huff-n-puff in shale reservoirs to achieve an improved (and optimal) oil recovery factor. The process determines and utilizes the optimum huff and puff times, number of cycles and soaking time under practical operation and reservoir conditions. The huff time in the process is a period so long that the pressure near the wellbore reaches the set maximum injection pressure during the huff period. The puff time in the process is the time required for the pressure near the wellbore to reach the set minimum production pressure during the puff period. Soaking is typically not necessary during the huff-n-puff gas injection in shale oil reservoirs. The number of huff-n-puff cycles is determinable by the time in which the economic rate cut-off is reached. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/221073 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/168 (20130101) Original (OR) Class E21B 47/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222570 | Jordan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | University of Connecticut (Farmington, Connecticut) |
| INVENTOR(S) | Eric Jordan (Storrs, Connecticut); Rishi Kumar (Ashford, Connecticut) |
| ABSTRACT | Thermal barrier coatings and methods to make such coatings present improved resistance to CMAS infiltration. The method for forming a thermal barrier coating includes applying a layer of the thermal barrier coating to a component having a surface, forming a plurality of first channels in the thermal barrier coating, and forming a plurality of second channels in the thermal barrier coating. The first channels extend through a thickness of the thermal barrier coating from an interface with the surface of the component to a free surface opposite the interface. The second channels are disposed between the free surface and the interface and extending lengthwise generally parallel to the free surface of the thermal barrier coating, wherein the thermal barrier coating comprises a material comprising yttrium aluminum garnet (YAG) or yttria stabilized zirconia (YSZ). |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085105 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/134 (20160101) C23C 14/28 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/288 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223073 | Sabharwall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Piyush Sabharwall (Idaho Falls, Idaho); Paul Marotta (Jersey City, New Jersey); Richard Christensen (Idaho Falls, Idaho); Nicholas Williams (Lapeer, Michigan); Jason Palmer (Rigby, Idaho) |
| ABSTRACT | Flow meters may include a body defining a fluid channel therein. At least one structure may be positioned within the fluid channel, and fixed relative to the body, that is shaped and positioned to produce a flow induced vibration that varies according to a rate of fluid flow through the fluid channel. A method of measuring a fluid flow rate may include directing a fluid over a first structure located in a first channel, and producing a first flow induced vibration that varies according to a rate of fluid flow in a first channel with the first structure. The method may further include measuring the vibration of a remote structure coupled to the first channel, and determining the rate of fluid flow in the first channel from the measured vibration. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/117427 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/3209 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223281 | Love et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Norman Love (El Paso, Texas); Yirong Lin (El Paso, Texas); Jad Aboud (El Paso, Texas); David Tucker (El Paso, Texas) |
| ABSTRACT | A method of measuring fluid flow rate is provided. The method comprises positioning a piezoelectric sensor in a fluid flow stream and measuring a voltage output from the piezoelectric sensor caused by mechanical stress from the fluid flow stream. A fluid flow rate is calculated based on the measured voltage output according to predefined relationships between the voltage output and a number physical parameters. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/100409 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/28 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 5/04 (20130101) G01P 5/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223805 | De Oliveira Vivi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rodrigo De Oliveira Vivi (Hillsboro, Oregon); John Kelbert (Aptos, California); David Lombard (Rossmoor, California); Eric Moret (Beaverton, Oregon); Mark Luckeroth (Portland, Oregon); Brad Bittel (Beaverton, Oregon); Phani Kumar Kandula (Bangalore, India) |
| ABSTRACT | Methods, apparatus, systems, and articles of manufacture to reduce thermal fluctuations in semiconductor processors are disclosed. An apparatus includes a temperature analyzer to determine a current temperature of a processor. The apparatus further includes a controller to provide an idle workload to the processor to execute in response to the current temperature falling below a setback temperature. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/133279 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 23/1917 (20130101) Original (OR) Class Electric Digital Data Processing G06F 9/4893 (20130101) G06F 9/5094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210225610 | Perea et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (, None) |
| INVENTOR(S) | Daniel E. Perea (Kennewick, Washington); James E. Evans (Richland, Washington); Jeffrey Ditto (Lake Oswego, Oregon) |
| ABSTRACT | A probe assembly for use with a charged particle instrument includes an elongate body having a proximal end for positioning outside of a charged particle instrument enclosed environment, a distal end for positioning within the enclosed environment and a longitudinal axis. A port interface is located on the body between the proximal and distal ends, and is coupleable to a nanomanipulator system of the charged particle instrument. A probe needle is positioned at a distal end of the body and is selectively positionable from outside the enclosed environment to contact a specimen within the enclosed environment. At least one gas injection needle is adjustably positioned near the probe needle. The gas injection needle is connectable to a source of pressurized gas to selectively inject gas in the area of the probe needle within the enclosed environment. |
| FILED | Tuesday, January 21, 2020 |
| APPL NO | 16/748705 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/28 (20130101) Original (OR) Class H01J 2237/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210225628 | Cahill et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John F. Cahill (Knoxville, Tennessee); Vilmos Kertesz (Oak Ridge, Tennessee); Scott T. Retterer (Knoxville, Tennessee) |
| ABSTRACT | A system for sampling a liquid includes a sample fluid conduit including a membrane having pores. The membrane prevents the passage of the sample liquid through the pores at a first pressure of the sample liquid in the sample fluid conduit. A surface sampling capture probe has a distal end. The capture probe includes a solvent supply conduit and a solvent exhaust conduit. A solvent composition flowing at the distal end of the capture probe establishes a liquid junction with the membrane and establishes a second pressure within the liquid junction at the membrane. The second pressure is lower than the first pressure. Sample liquid will be drawn through the pores of the membrane by the second pressure at the liquid junction. A method for sampling a liquid and for performing chemical analysis on a liquid are also disclosed. |
| FILED | Thursday, January 16, 2020 |
| APPL NO | 16/744980 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/10 (20130101) G01N 30/7233 (20130101) G01N 35/1095 (20130101) G01N 2001/028 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0454 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226115 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhong Lin Wang (Atlanta, Georgia); Haiyang Zou (Atlanta, Georgia) |
| ABSTRACT | An apparatus comprising a substrate, one or more nanowire pillars, each having a base portion and a tip portion, a first electrode connected to the tip portions of the one or more nanowire pillars, an internal hollow cavity positioned between the substrate and the first electrode, such that at least a portion of each of the one or more nanowire pillars extend through the internal hollow cavity, and a second electrode proximate the first side of the substrate. High-performance broadband photodetectors and other optoelectronics for converting light to electricity with enhanced absorption and carrier collection. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/098779 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1884 (20130101) H01L 31/022466 (20130101) H01L 31/035227 (20130101) H01L 41/27 (20130101) H01L 41/083 (20130101) Original (OR) Class H01L 41/0471 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226193 | SAKAMOTO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JEFFREY SAKAMOTO (Ann Arbor, Michigan); MICHAEL WANG (Ann Arbor, Michigan) |
| ABSTRACT | The present disclosure relates to a method of electrodeposition using pulsed currents to improve the uniformity of electrodeposited materials at solid-solid interfaces. It has been demonstrated that films of electrodeposited metals can be robustly deposited at a solid-solid interface without damage to the solid-electrolyte. Furthermore, the effects of the pulse parameters, including current density, pulse width, and duty cycle have shown to have dramatic effects on the spatial distribution of the electrodeposited metal. This methodology can aid in the manufacturing of thin films and microscopic structures for application in advanced functional materials and electrochemical devices. In one embodiment, the method provides for anode-free manufacturing in which a battery is fabricated in the discharged state, with a bare current collector replacing the conventional anode, and a metal anode is then formed electrochemically on the first charge cycle by electroplating a metal contained within the cathode. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154176 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/043 (20130101) H01M 4/0452 (20130101) Original (OR) Class H01M 10/052 (20130101) H01M 10/0562 (20130101) H01M 10/0585 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226203 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tongchao Liu (Westmont, Illinois); Jun Lu (Naperville, Illinois); Khalil Amine (Oakbrook, Illinois) |
| ABSTRACT | A cathode active material of formula LiNixMnyAlzMαO2-εBε or NaNix′Mny′Alz′M′α′O2-ε′Bε′, wherein M is a combination of Ti, and Mg; M′ is Ti, Mg, or a combination of thereof; B is selected from the group of F, S, Se, or Cl; 0.8<x<1, 0<y<0.2, 0<z≤0.2, 0≤α≤0.2, 0≤ε≤0.1, 0.5<x′<1, 0<y′<0.5, 0<z′≤0.2, 0≤α′≤0.2, and 0≤ε′≤0.1. The particle is a single crystal, a single particle, or a secondary particle comprising a plurality of primary particles; and the particle is a uniform composition or a concentration gradient composition. |
| FILED | Wednesday, January 22, 2020 |
| APPL NO | 16/749239 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/50 (20130101) C01G 53/66 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/52 (20130101) C01P 2002/85 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2004/32 (20130101) C01P 2004/61 (20130101) C01P 2004/64 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) Original (OR) Class H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226247 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiangwu Zhang (Raleigh, North Carolina); Chaoyi Yan (Raleigh, North Carolina); Mahmut Dirican (Raleigh, North Carolina) |
| ABSTRACT | Composite solid electrolytes (CSE) and metal or metal ion energy storage devices that include a CSE are provided. The CSE can include silane-decorated ceramic nanofibers a polymeric material, and a plurality of metal ions. The energy storage device includes a CSE operably coupled with an anode and a cathode. Methods for making a composite solid electrolyte are also provided. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/096457 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/58 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 10/0565 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226263 | PARK |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyusung PARK (Greenwood Village, Colorado) |
| ABSTRACT | Disclosed herein are improved methods and devices for recycling lithium cathodes from batteries. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/087303 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/4242 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226273 | PARK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyusung PARK (Greenwood Village, Colorado); Anthony Keiran BURRELL (Golden, Colorado) |
| ABSTRACT | Disclosed herein are improved methods and devices for recycling lithium cathodes from batteries using a Soxhlet extractor. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/087468 |
| CURRENT CPC | Separation B01D 11/0203 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/622 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/4285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226311 | Roberts |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brock Franklin Roberts (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brock Franklin Roberts (Albuquerque, New Mexico) |
| ABSTRACT | The harmonic combiner and divider efficiently combines multiple harmonic signals onto a common transmission line. Combined harmonic signals can be used to generate fast, high-fidelity arbitrary waveforms by superimposing the harmonics described in their Fourier series. Fast arbitrary waveforms have applications in communications, radar, and can be used for manipulating and controlling charged particle beams. The harmonic combiner and divider also efficiently divides fast arbitrary waveforms into their constituent harmonics and provides an efficient mechanism for waveform analysis and for multi-channel communications. |
| FILED | Thursday, January 16, 2020 |
| APPL NO | 16/873026 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 5/19 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226364 | KHALIGH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fariborz MUSAVI (, None); UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alireza KHALIGH (Arlington, Virginia); Fariborz MUSAVI (Redmond, Washington) |
| ABSTRACT | In some embodiments, systems and methods for connector assembly for use with an AC or DC power interface of a power conversion device, such as a converter and an inverter, are provided. The connector assembly can include a circuit board, a power connector, and a pin. The power connector can have a base configured to be secured relative to the circuit board and define a first channel extending through the power connector along a first channel axis. The first pin can have a first pin body that extends along a first pin axis and a first connection element that extends along the first pin axis from the first pin body to a first terminal end that is skewed relative to the first pin axis. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/087343 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 12/7082 (20130101) Original (OR) Class H01R 13/2471 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/32 (20141201) H02S 40/36 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226578 | Basel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SUNFOLDING, INC. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louis Hong Basel (Berkeley, California); Kyle Douglass Betts (San Francisco, California); Alex Tan Kwan (San Gabriel, California); Jeffrey Charles Lamb (San Francisco, California); Erica S. C. Lin (Millbrae, California); Leila Madrone (San Francisco, California); James Vincent Nolan, IV (San Francisco, California); Matthew N Schneider (Sierra Madre, California); Youngjoo Shin (Chandler, Arizona); Eric Preston Lien Suan (Baltimore, Maryland) |
| ABSTRACT | A fluidic actuator including an angled bottom plate having a cap and first and second plate arms on opposing sides of and extending from the cap. The fluidic actuator further includes a top plate coupled about the cap of the angled bottom plate and a rotatable coupling of the angled bottom plate and top plate. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/130397 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/142 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/10 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 30/425 (20180501) F24S 50/20 (20180501) F24S 2030/12 (20180501) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/042 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/10 (20141201) H02S 20/32 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210226583 — AUTONOMOUS SOLAR FIELD AND RECEIVER INSPECTIONS BASED ON POLARIMETRIC-ENHANCED IMAGING
| US 20210226583 | Yao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona); Sandia National Laboratories (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu Yao (Chandler, Arizona); Chao Wang (Chandler, Arizona); Julius Yellowhair (Albuquerque, New Mexico); Jing Bai (Tempe, Arizona); Jiawei Zuo (Tempe, Arizona) |
| ABSTRACT | Provided herein are systems and related methods of performing solar field and receiver inspections based on polarimetric-enhanced imaging. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/153769 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/127 (20130101) Image Data Processing or Generation, in General G06T 7/0004 (20130101) G06T 2207/10032 (20130101) G06T 2207/10048 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 50/15 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226999 | Fisk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Triad National Security, LLC (Los Alamos, Minnesota) |
| ASSIGNEE(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Michael Edward Fisk (Los Alamos, New Mexico); Joshua Charles Neil (Los Alamos, New Mexico) |
| ABSTRACT | Processes for determining whether new subgraphs that are observed locally in dynamic graphs are indicative of anomalous behavior are disclosed. Community models including certain factors, such as the rate of creation of new subgraphs of given structures and labels, may provide a basis for measuring the likelihood of newly observed subgraphs. For instance, edge labels including attributes for these specific shapes, such as port numbers and/or other categories, may differentiate legitimate new local occurrences thereof from those that are anomalous. Such processes may have applications including anomaly detection in computer networks, distributed systems, other patterns of life applications including dynamic graphs (e.g., dynamic directed multi graphs), etc. |
| FILED | Tuesday, August 06, 2019 |
| APPL NO | 17/266916 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210227445 | Russell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John L. Russell (Albuquerque, New Mexico); David A. Wiegandt (Albuquerque, New Mexico); Dahlon D. Chu (Albuquerque, New Mexico); Kevin Robbins (Albuquerque, New Mexico); Douglas G. Brown (Cedar Crest, New Mexico); Dominic A. Perea (Albuquerque, New Mexico); Loren E. Riblett, JR. (Edgewood, New Mexico) |
| ABSTRACT | Systems and methods for ultra-high reliability (UHR) wireless communications systems and methods are disclosed. The disclosed UHR wireless communications systems and methods make the networked components on a communications infrastructure robust to interference caused by unintentional jamming, intermittent connectivity, weather, and physical barriers. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/201130 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/12 (20130101) Wireless Communication Networks H04W 4/02 (20130101) H04W 40/16 (20130101) Original (OR) Class H04W 48/18 (20130101) H04W 84/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210227678 | Tang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent Tang (Dublin, California); Glenn A. Meyer (Danville, California); Steven Falabella (Livermore, California); Gary Guethlein (Livermore, California); Brian Rusnak (Livermore, California); Stephen Sampayan (Manteca, California); Christopher Spadaccini (Oakland, California); Li-Fang Wang (Livermore, California); John Harris (Monterey, California); Jeff Morse (Westhampton, Massachusetts) |
| ABSTRACT | A method for producing a neutrons includes producing a voltage of negative polarity of at least −100 keV on a surface of a deuterated or tritiated target in response to a temperature change of a pyroelectric crystal of less than about 40° C., the pyroelectric crystal having the deuterated or tritiated target coupled thereto, pulsing a deuterium ion source to produce a deuterium ion beam, accelerating the deuterium ion beam to the deuterated or tritiated target, and directing the ion beam onto the deuterated or tritiated target to make neutrons using at least one element of the following: a voltage of the pyroelectric crystal and a high gradient insulator (HGI) surrounding the pyroelectric crystal. The accelerating of the deuterium ion beam is achieved by using an ion accelerating mechanism comprising a pyroelectric stack accelerator having a first thermal altering mechanism for changing a temperature of the pyroelectric stack accelerator. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 17/122918 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 4/02 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 3/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210219852 | COLBURN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | David COLBURN (New York, New York); Samuel K. SIA (New York, New York) |
| ABSTRACT | The disclosed subject matter includes a wearable device for cuffless blood pressure monitoring that does not require external per-person calibration, such as with a cuff-based measurement device. The embodiment employs photoplethysmography sensors to obtain pulse wave velocity and develops compensation for external pressure influences. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204352 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/0245 (20130101) A61B 5/681 (20130101) A61B 5/02125 (20130101) Original (OR) Class A61B 5/02416 (20130101) A61B 5/7264 (20130101) A61B 8/488 (20130101) A61B 2560/0223 (20130101) A61B 2560/0261 (20130101) A61B 2562/0219 (20130101) A61B 2562/0223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210219899 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin He (Arden Hills, Minnesota); Zhaoye Zhou (Minneapolis, Minnesota) |
| ABSTRACT | A system and method for non-invasively generating a report of cardiac electrical activities of a subject includes determining, using cardiac electrical activation information, equivalent current densities (ECDs). The ECDs are assembled into time-course ECD information and a spectrum of the time-course ECD information is analyzed to determine peaks for spectral characteristics of atrial fibrillation (AF). The spectral characteristics of AF are correlated with potential electrical sources of the AF and a report is generated indicating the potential electrical sources of the AF spatially registered with the medical imaging data. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/013003 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/316 (20210101) Original (OR) Class A61B 5/333 (20210101) A61B 5/361 (20210101) A61B 6/032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220289 | COFFMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Elektrofi, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chase COFFMAN (Boston, Massachusetts); Lyndon CHARLES, Jr. (Medford, Massachusetts); Paul BROWN (Boston, Massachusetts); Daniel Benjamin DADON (East Boston, Massachusetts); Lisa LIU (Somerville, Massachusetts); Sadiqua SHADBAR (Allston, Massachusetts); Chaitanya SUDRIK (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability. |
| FILED | Friday, May 24, 2019 |
| APPL NO | 17/058339 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5192 (20130101) Original (OR) Class A61K 31/167 (20130101) A61K 45/06 (20130101) A61K 47/02 (20130101) A61K 47/14 (20130101) A61K 47/26 (20130101) A61K 47/186 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220553 | Cho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sung Kwon Cho (Pittsburgh, Pennsylvania); Fang-Wei Liu (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system includes a delivery system a tube having a first open end and a second closed end, wherein the inner wall of the tube exhibits or includes surface roughness, a first liquid volume including a first liquid within the tube, and a first gas volume within the tube adjacent the first open end and separating the first liquid volume from a surrounding environment. The system further include a drive system, remote from the delivery system, which is configured to transmit a signal to controllably oscillate the first gas volume and one or more other gas volumes within the tube. |
| FILED | Sunday, January 17, 2021 |
| APPL NO | 17/151173 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/14276 (20130101) Original (OR) Class A61M 2205/3507 (20130101) A61M 2205/3553 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/17 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220587 | Gholami et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Autonomous Healthcare, Inc. (Hoboken, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Behnood Gholami (Hoboken, New Jersey); Timothy S. Phan (Brooklyn, New York) |
| ABSTRACT | The present disclosure describes a system that automatically detects patient-ventilator asynchrony and trends in patient-ventilator asynchrony. The present disclosure describes a framework that uses pressure, flow, and volume waveforms to detect patient-ventilator asynchrony and the presence of secretions in the ventilator circuit. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/201684 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/024 (20170801) Original (OR) Class A61M 16/026 (20170801) A61M 2016/0027 (20130101) A61M 2016/0033 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/3379 (20130101) A61M 2205/3584 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221850 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Holland Cheng (Oakland, California); Chun Chieh Chen (Oakland, California); Mohammad Ali Baikoghli (Oakland, California); Marie Stark (Oakland, California) |
| ABSTRACT | A Hepatitis E virus (HEV)-based virus like nanoparticle (HEVNP) made with a modified capsid protein containing at least a portion of open reading frame 2 (ORF2) protein conjugated with gold nanocluster is provided. Also provided are methods of targeted delivery of a nucleic acid using the HEVNP. |
| FILED | Thursday, June 06, 2019 |
| APPL NO | 15/734877 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/62 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/28122 (20130101) C12N 2770/28123 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221858 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabsang Lee (Ellicott City, Maryland); Hyesoo Kim (Baltimore, Maryland); InYoung Choi (Baltimore, Maryland); HoTae Lim (Baltimore, Maryland); Alex V. Huynh (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of stem cells. More specifically, the present invention provides compositions and methods for using optogenetics to sustain the pluripotency of stem cells. In one embodiment, a vector comprises a nucleotide sequencing encoding a fusion protein comprising the intracellular domain of fibroblast growth factor 1 receptor (FGFR1) and a photoactivatable domain. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152220 |
| CURRENT CPC | Peptides C07K 14/71 (20130101) C07K 14/405 (20130101) Original (OR) Class C07K 2319/02 (20130101) Apparatus for Enzymology or Microbiology; C12M 31/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0696 (20130101) C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221904 | ZURAWSKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| ASSIGNEE(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| INVENTOR(S) | Gerard ZURAWSKI (Midlothian, Texas); Jacques F. Banchereau (Montclair, New Jersey); Anne-Laure FLAMAR (New York, New York); Yves Levy (, None); Monica Montes (Dallas, Texas) |
| ABSTRACT | The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/301118 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/385 (20130101) A61K 2039/6056 (20130101) Peptides C07K 14/005 (20130101) C07K 16/00 (20130101) C07K 16/2878 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222147 | PTACIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SYNTHORX, INC. (La Jolla, California); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerod PTACIN (La Jolla, California); Carolina CAFFARO (La Jolla, California); Hans AERNI (La Jolla, California); Yorke ZHANG (La Jolla, California); Emil C. FISCHER (La Jolla, California); Aaron W. FELDMAN (La Jolla, California); Vivian T. DIEN (La Jolla, California); Floyd E. ROMESBERG (La Jolla, California) |
| ABSTRACT | Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196151 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class C12N 15/90 (20130101) C12N 15/113 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222155 | Barbieri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Barbieri (Lindenhurst, New York); Farren Isaacs (Stamford, Connecticut) |
| ABSTRACT | Compositions and methods for gene editing are provided. The methods employ an oligo-based annealing mechanism that is rooted in the process of DNA replication rather than homologous recombination (HR). Oligo incorporation efficiencies are comparable and often exceed those of CRISPR/cas9 editing without the need for double strand breaks (DSBs). By relying on the multiplex annealing of oligos rather than DSBs the process is highly scalable across a genomic region of interest and can generate many scarless modifications of a chromosome simultaneously. Combinatorial genomic diversity can be generated across a population of cells in a single transformation event; genomic landscapes can be traversed through successive iterations of the process, and genome-wide changes can be massively parallelized and amplified through systematic strain mating. |
| FILED | Thursday, April 27, 2017 |
| APPL NO | 16/097091 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222204 | Rose et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | John C. Rose (Seattle, Washington); Dustin James Maly (Seattle, Washington); Douglas Fowler (Seattle, Washington); Nicholas Popp (Seattle, Washington) |
| ABSTRACT | The disclosure provides compositions and methods for suppressing off-target editing guide RNA-nuclease complexes. The disclosed strategies incorporate use of catalytically inactive truncated guide RNA/nuclease complexes to shield off-target editing. In some embodiments, the disclosure provides a method of inhibiting off-target cleavage of DNA by a first guide RNA-endonuclease complex by contacting the DNA with a second guide RNA-endonuclease complex that comprises a second guide RNA corresponding to the off-target site but with a recognition sequence of 16 or fewer nucleotides. In another aspect, the disclosure provides a method for preventing cleavage of DNA after editing and subsequent homology-directed repair (HDR) by contacting the repaired DNA with a guide RNA-endonuclease complex that comprises a guide RNA with a guide RNA corresponding to the repaired sequence but with a recognition sequence of 16 or fewer nucleotides. Additional methods, compositions, and kits are also provided. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/144944 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222329 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Xiaochun Li (Manhattan Beach, California); Abdolreza Javadi (Los Angeles, California); Jingzhou Zhao (Los Angeles, California) |
| ABSTRACT | A method of forming a polymer-metal nanocomposite (PMNC) material with a substantially uniform dispersion of metal particles includes forming a composite solid preform by mixing a blend of micrometer-sized metal particles and polymer particles and subjecting the mixture to compression followed by sintering. The composite solid preform is drawn through a heated zone to form a reduced size fiber. The reduced size fiber is cut into segments and a next preform is formed using the bundle of the segments. The next preform is then drawn through the heated zone to form yet another reduced size fiber. This reduced size fiber may undergo one or more stack-and-draw operations to yield a final fiber having substantially uniform dispersion of nanometer-sized metal particles therein. |
| FILED | Wednesday, June 07, 2017 |
| APPL NO | 16/308430 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 43/003 (20130101) B29C 43/006 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/08 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/02 (20130101) Original (OR) Class Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/09 (20130101) D01F 6/66 (20130101) D01F 6/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223170 | ESCARRA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew David ESCARRA (New Orleans, Louisiana); Adam OLLANIK (Boulder, Colorado) |
| ABSTRACT | A method for measuring a refractive index of a medium includes exciting a first antisymmetric resonance of a first metasurface, including a first periodic array of resonators formed on a substrate surface, with illumination incident on the first metasurface at a non-normal incidence angle with respect to the substrate surface, the first metasurface including the medium encapsulating the first periodic array of resonators. The method also includes determining a refractive index of the medium from a first amplitude of a first transmitted signal that includes a portion of the illumination transmitted through the first metasurface. |
| FILED | Monday, May 13, 2019 |
| APPL NO | 17/055833 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/4133 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223177 | RAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Govind RAO (Ellicott City, Maryland); Yordan KOSTOV (Ellicott City, Maryland); Mustafa AL-ADHAMI (Silver Spring, Maryland); Chandrasekhar GURRAMKONDA (Baltimore, Maryland) |
| ABSTRACT | A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/156915 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 2300/0867 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2304/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/645 (20130101) G01N 21/6428 (20130101) Original (OR) Class G01N 2021/0112 (20130101) G01N 2333/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223240 | STOJANOVIC et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Milan STOJANOVIC (Ridgewood, New Jersey); Anne Milasincic ANDREWS (Los Angeles, California); Kyungae YANG (New York, New York); Paul S. WEISS (Los Angeles, California); Nako NAKATSUKA (Adliswill, Switzerland) |
| ABSTRACT | Devices for detecting at least one target molecule in a sample are provided. The devices comprise a field-effect transistor and an aptamer attached to the field-effect transistor. The aptamer comprises a capture region and a stem region, wherein the target molecule can selectively bind to the capture region of the aptamer. The stem region can change a conformation of the aptamer when the capture region binds to the target molecule. Techniques for detecting a target molecule using such devices are also provided. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175190 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4145 (20130101) G01N 27/4148 (20130101) G01N 33/6818 (20130101) G01N 33/54373 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223281 | Love et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Norman Love (El Paso, Texas); Yirong Lin (El Paso, Texas); Jad Aboud (El Paso, Texas); David Tucker (El Paso, Texas) |
| ABSTRACT | A method of measuring fluid flow rate is provided. The method comprises positioning a piezoelectric sensor in a fluid flow stream and measuring a voltage output from the piezoelectric sensor caused by mechanical stress from the fluid flow stream. A fluid flow rate is calculated based on the measured voltage output according to predefined relationships between the voltage output and a number physical parameters. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/100409 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/28 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 5/04 (20130101) G01P 5/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223288 | WEIKLE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Robert M. WEIKLE (Crozet, Virginia); Linli XIE (Charlottesville, Virginia); Michael E. CYBEREY (Charlottesville, Virginia); Souheil NADRI (Charlottesville, Virginia); Matthew F. BAUWENS (Chesapeake, Virginia); Arthur Weston LICHTENBERGER (Charlottesville, Virginia); Nicolas Scott BARKER (Charlottesville, Virginia) |
| ABSTRACT | A probe chip device and a method for fabricating a probe chip device with an integrated diode sensor are disclosed. In one example, a probe chip device includes a beam head element that includes at least one probe tip that is configured to electrically probe a device under test. The probe chip device further includes a diode sensor that is heterogeneously integrated on the beam head element and is proximally positioned to the at least one probe tip. |
| FILED | Friday, May 10, 2019 |
| APPL NO | 17/053930 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/015 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 1/06772 (20130101) Original (OR) Class G01R 3/00 (20130101) G01R 19/0046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210224330 | Miranker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | data.world, Inc. (Austin, Texas) |
| ASSIGNEE(S) | data.world, Inc. (Austin, Texas) |
| INVENTOR(S) | Daniel Paul Miranker (Austin, Texas); Juan Federico Sequeda (Austin, Texas) |
| ABSTRACT | The invention is a system for integrating data sets organized in one organization type with data sets organized in a second organization type so that data queries submitted to be processed in the manner of the first organization type can be translated into queries usable by the data set in the second data organization type and the results returned to satisfy the first query. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/114385 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/25 (20190101) G06F 16/81 (20190101) G06F 16/86 (20190101) G06F 16/353 (20190101) G06F 16/8358 (20190101) G06F 16/8365 (20190101) G06F 16/90332 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210224678 | WAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Noel WAN (Cambridge, Massachusetts); Jacques Johannes CAROLAN (Cambridge, Massachusetts); Tsung-Ju Lu (Cambridge, Massachusetts); Ian Robert Christen (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Noel WAN (Cambridge, Massachusetts); Jacques Johannes CAROLAN (Cambridge, Massachusetts); Tsung-Ju Lu (Cambridge, Massachusetts); Ian Robert Christen (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | A process is provided for the high-yield heterogeneous integration of ‘quantum micro-chiplets’ (QMCs, diamond waveguide arrays containing highly coherent color centers) with an aluminum nitride (AlN) photonic integrated circuit (PIC). As an example, the process is useful for the development of a 72-channel defect-free array of germanium-vacancy (GeV) and silicon-vacancy (SiV) color centers in a PIC. Photoluminescence spectroscopy reveals long-term stable and narrow average optical linewidths of 54 MHz (146 MHz) for GeV (SiV) emitters, close to the lifetime-limited linewidth of 32 MHz (93 MHz). Additionally, inhomogeneities in the individual qubits can be compensated in situ with integrated tuning of the optical frequencies over 100 GHz. The ability to assemble large numbers of nearly indistinguishable artificial atoms into phase-stable PICs is useful for development of multiplexed quantum repeaters and general-purpose quantum computers. |
| FILED | Monday, January 06, 2020 |
| APPL NO | 16/734727 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/005 (20130101) H01L 33/06 (20130101) H01L 33/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226609 | BAHAMONDE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose Antonio BAHAMONDE (New York, New York); Ioannis KYMISSIS (New York, New York) |
| ABSTRACT | A non-reciprocal filter with parametric amplification to obtain non-reciprocal propagation of forward and reverse signals is disclosed. The non-reciprocal filter may include two asymmetrical transmission lines and a current source. The filter, when implemented in the acoustics domain using surface acoustic waves (SAW), may operate in a phase-coherent or a phase-incoherent degenerate mode, providing low insertion loss and high decibels of isolation. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150579 |
| CURRENT CPC | Amplifiers H03F 7/00 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/64 (20130101) Original (OR) Class H03H 9/145 (20130101) H03H 9/02559 (20130101) H03H 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226670 | Almasi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOISE STATE UNIVERSITY (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mojtaba Ahmadi Almasi (Boise, Idaho); Hani Mehrpouyan (Boise, Idaho) |
| ABSTRACT | A system may include a radio frequency chain configured to process a signal. The system may further include a reconfigurable antenna including multiple antenna feeds, each of the antenna feeds associated with a beam direction. The system may also include a beam selection network configured to couple the radio frequency chain to a first antenna feed of the multiple antenna feeds to generate a first beam in a first direction, and simultaneously couple the radio frequency chain to a second antenna feed of the multiple antenna feeds to generate a second beam in a second direction. |
| FILED | Monday, October 12, 2020 |
| APPL NO | 17/068638 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/36 (20130101) H01Q 1/241 (20130101) Transmission H04B 7/024 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210226803 | Traynor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick G. Traynor (Gainesville, Florida); Bradley G. Reaves (Raleigh, North Carolina); Logan E. Blue (Palm Bay, Florida) |
| ABSTRACT | Methods and apparatuses for providing cryptographic authentication within a voice channel are disclosed. The methods and apparatuses can provide cryptographic authentication solely within a voice channel or can use a combination of a voice channel and another data channel. A method for providing cryptographic authentication within a voice channel can operate between telephonic systems and be suitable for operating over G.711/PCMu, AMR and SPEEX™ codecs, and suitable for operating over mobile, PSTN, and VOIP networks. The method can include providing a modem that is codec agnostic and suitable for executing a TLS-based authentication protocol. The method can include using frequency-shift modulation within a frequency range of 300-3400 Hz. |
| FILED | Thursday, June 08, 2017 |
| APPL NO | 16/304412 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0825 (20130101) H04L 9/3066 (20130101) H04L 9/3242 (20130101) H04L 9/3268 (20130101) Original (OR) Class H04L 27/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210219862 | Loecher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government As Represented By The Department Of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Loecher (Santa Monica, California); Daniel B. Ennis (Palo Alto, California) |
| ABSTRACT | A method for magnetic resonance imaging (MRI) tag tracking includes: synthetically generating tagged data from natural images combined with programmed tag motion and a full Bloch simulation; training a convolutional neural network (CNN) with the synthetically generated tagged data to generate grid tag motion paths; acquiring MRI images using a tagged imaging method; inputting the acquired images into the CNN to estimate motion paths of tracked points; and determining from the estimated motion paths a path of tag lines through the cardiac cycle from a set of tagged MRI images. The method can calculate strain curves from the estimated motion paths using Ecc derivation. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152302 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0044 (20130101) A61B 5/055 (20130101) Original (OR) Class A61B 5/318 (20210101) A61B 5/748 (20130101) A61B 5/1128 (20130101) A61B 5/7267 (20130101) A61B 5/7289 (20130101) A61B 2576/023 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210220331 | Gera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The United State Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph F. Gera (Lancaster, California); Alan Lichtenstein (Encino, California); Michael E. Jung (Los Angeles, California); Jihye Lee (Yeonsu-gu, Incheon, South Korea); Brent Holmes (Inglewood, California); Angelica Benavides-Serrato (Grenada Hills, California) |
| ABSTRACT | This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors. |
| FILED | Wednesday, May 03, 2017 |
| APPL NO | 16/098784 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 31/502 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/4015 (20130101) Original (OR) Class A61K 31/4035 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 207/448 (20130101) C07D 207/452 (20130101) C07D 207/456 (20130101) C07D 209/48 (20130101) C07D 217/24 (20130101) C07D 237/32 (20130101) C07D 239/54 (20130101) C07D 239/96 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210221030 | STOECKL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BRENDAN D. STOECKL (Philadelphia, Pennsylvania); ROBERT L. MAUCK (Philadelphia, Pennsylvania); HANNAH ZLOTNICK (Philadelphia, Pennsylvania); MEGAN FARRELL (Philadelphia, Pennsylvania); LIANE MILLER (Philadelphia, Pennsylvania); DAVID STEINBERG (Philadelphia, Pennsylvania) |
| ABSTRACT | A method for forming a prosthesis comprising a bone-like portion and a cartilage-like portion can comprise additively manufacturing a first positive mold in accordance with a portion of a first three-dimensional model of a portion of a bone. A first negative mold can be formed from the first positive mold. The bone-like portion can be created within the first negative mold. A second positive mold of the bone and a cartilage can be additively manufactured from a second three-dimensional model. A portion of the second three-dimensional model can correspond to a portion of the first three-dimensional model. A second negative mold can be formed from the second positive mold. The bone-like portion can be positioned in the second negative mold so that the second negative mold and the bone-like portion can define a cartilage space that can be filled with a material to form the cartilage-like portion of the prosthesis. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152647 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/4261 (20130101) A61F 2/30942 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/26 (20130101) A61L 27/52 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/3842 (20130101) Original (OR) Class B29C 64/386 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2067/04 (20130101) B29K 2883/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210220803 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yat Li (Santa Cruz, California); Tianyi Kou (Santa Cruz, California); Mingpeng Chen (Santa Cruz, California) |
| ABSTRACT | A catalyst composition including nickel foam and a plurality of carbon-doped nickel oxide nanorods disposed on the nickel foam. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/153383 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/755 (20130101) Original (OR) Class B01J 27/20 (20130101) B01J 35/04 (20130101) B01J 35/0073 (20130101) B01J 37/08 (20130101) B01J 37/348 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/26 (20130101) C01B 2203/1058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210223387 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Wang (Boulder, Colorado); Yu T. Morton (Boulder, Colorado) |
| ABSTRACT | A direct line-of-sight (DLOS) radio frequency (RF) signal component and a reflected RF signal component of an RF carrier signal are received from a transmitter. The reflected component is reflected from a point on the surface of the earth. The DLOS component is converted to a digital DLOS intermediate frequency (IF) signal and the reflected component that is converted to a digital reflected IF signal. Modeled reference signal parameters are generated using the digital DLOS IF signal and known locations of the one or more antennas, the transmitter, and the point. A reference signal is generated based on the modeled reference signal parameters and feedback of a previously estimated phase correction (Δϕ). The reference signal is correlated with the digital reflected IF signal to produce in-phase and quadrature-phase correlation results. Estimated carrier-to-noise ratio (C/N0) and Δϕ values are calculated for the digital reflected IF signal from the correlation results. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/141450 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/003 (20130101) G01S 13/89 (20130101) Original (OR) Class G01S 19/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210225177 | KOSTIUK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Robust Analytics, Inc. (Crofton, Maryland) |
| ASSIGNEE(S) | Robust Analytics, Inc. (Crofton, Maryland) |
| INVENTOR(S) | Peter F KOSTIUK (Crofton, Maryland); Hugo KANG (Crofton, Maryland); Michael MOHEN (Crofton, Maryland) |
| ABSTRACT | A system, a method, and a computer program embodied on a non-transitory computer-readable medium, the program configured to cause at least one processor to perform steps including gathering observations and forecasts of a plurality of aviation environmental and operational data of a terminal airspace, independently transforming the observations and forecasts into respective terminal airspace risk factors; integrating the terminal airspace risk factors into operational time periods; weighting the integrated terminal airspace risk factors into an overall airspace risk score for each operational time period; categorizing the overall airspace risk score into a terminal airspace risk category based upon at least one predetermined risk score threshold; and displaying the risk categories and selected underlying risk factors data on a map with a plurality of display panes. |
| FILED | Tuesday, January 21, 2020 |
| APPL NO | 16/748321 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/06 (20130101) Electric Digital Data Processing G06F 3/0482 (20130101) Traffic Control Systems G08G 5/0026 (20130101) G08G 5/0043 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20210220823 | McFarland et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirsty A. McFarland (Melrose, Massachusetts); Charles A. Lissandrello (Newtonville, Massachusetts); Andrew P. Magyar (Arlington, Massachusetts); Erin Rosenberger (Quincy, Massachusetts) |
| ABSTRACT | Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency. |
| FILED | Friday, October 12, 2018 |
| APPL NO | 16/755505 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50853 (20130101) Original (OR) Class B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 7/00 (20130101) B01L 2200/16 (20130101) B01L 2200/0689 (20130101) B01L 2300/044 (20130101) B01L 2300/168 (20130101) B01L 2300/0636 (20130101) Centrifuges B04B 3/00 (20130101) B04B 5/0414 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210224678 | WAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Noel WAN (Cambridge, Massachusetts); Jacques Johannes CAROLAN (Cambridge, Massachusetts); Tsung-Ju Lu (Cambridge, Massachusetts); Ian Robert Christen (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Noel WAN (Cambridge, Massachusetts); Jacques Johannes CAROLAN (Cambridge, Massachusetts); Tsung-Ju Lu (Cambridge, Massachusetts); Ian Robert Christen (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | A process is provided for the high-yield heterogeneous integration of ‘quantum micro-chiplets’ (QMCs, diamond waveguide arrays containing highly coherent color centers) with an aluminum nitride (AlN) photonic integrated circuit (PIC). As an example, the process is useful for the development of a 72-channel defect-free array of germanium-vacancy (GeV) and silicon-vacancy (SiV) color centers in a PIC. Photoluminescence spectroscopy reveals long-term stable and narrow average optical linewidths of 54 MHz (146 MHz) for GeV (SiV) emitters, close to the lifetime-limited linewidth of 32 MHz (93 MHz). Additionally, inhomogeneities in the individual qubits can be compensated in situ with integrated tuning of the optical frequencies over 100 GHz. The ability to assemble large numbers of nearly indistinguishable artificial atoms into phase-stable PICs is useful for development of multiplexed quantum repeaters and general-purpose quantum computers. |
| FILED | Monday, January 06, 2020 |
| APPL NO | 16/734727 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/005 (20130101) H01L 33/06 (20130101) H01L 33/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Classified Government Agency
| US 20210224213 | RAJ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swapna RAJ (Norwalk, Connecticut); Samantika S. SURY (Westford, Massachusetts); Kermin CHOFLEMING (Hudson, Massachusetts); Simon C. STEELY, JR. (Hudson, New Hampshire) |
| ABSTRACT | Examples include techniques for near data acceleration for a multi-core architecture. A near data processor included in a memory controller of a processor may access data maintained in a memory device coupled with the near data processor via one or more memory channels responsive to a work request to execute a kernel, an application or a loop routine using the accessed data to generate values. The near data processor provides an indication to the requestor of the work request that values have been generated. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/206961 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0815 (20130101) G06F 13/1668 (20130101) G06F 13/4027 (20130101) Original (OR) Class G06F 2212/1024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210221850 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Holland Cheng (Oakland, California); Chun Chieh Chen (Oakland, California); Mohammad Ali Baikoghli (Oakland, California); Marie Stark (Oakland, California) |
| ABSTRACT | A Hepatitis E virus (HEV)-based virus like nanoparticle (HEVNP) made with a modified capsid protein containing at least a portion of open reading frame 2 (ORF2) protein conjugated with gold nanocluster is provided. Also provided are methods of targeted delivery of a nucleic acid using the HEVNP. |
| FILED | Thursday, June 06, 2019 |
| APPL NO | 15/734877 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/62 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/28122 (20130101) C12N 2770/28123 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20210226113 | David et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald David (Broomfield, Colorado); David Pappas (Boulder, Colorado); Xian Wu (Westminster, Colorado) |
| ABSTRACT | This disclosure describes systems, methods, and apparatus for multilayer superconducting structures comprising electroplated Rhenium, where the Rhenium operates in a superconducting regime at or above 4.2 K, or above 1.8 K where specific temperatures and times of annealing have occurred. The structure can include at least a first conductive layer applied to a substrate, where the Rhenium layer is electroplated to the first layer. A third layer formed from the same or a different conductor as the first layer can be formed atop the Rhenium layer. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/221346 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/043 (20130101) B32B 2255/06 (20130101) B32B 2255/205 (20130101) B32B 2307/202 (20130101) B32B 2457/08 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 12/02 (20130101) H01B 12/06 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/12 (20130101) Original (OR) Class H01L 39/14 (20130101) H01L 39/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 20210220439 | Wagner |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEMS OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Amy Kathleen Wagner (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure relates to methods and compositions for treating traumatic brain injury (TBI) and TBI-associated impairments and improving outcome in subjects that have sustained traumatic brain injury comprising administering to the subject a sgp130 or an agent that promotes the binding of sgp130 and sIL-6R and/or reduces sIL-6R mediated trans-signaling. The present disclosure also relates to methods and kits for identifying a subject that is at risk of developing a TBI-associated impairment (e.g., headache, depression, cognitive deficits, and seizure) or monitoring the responsiveness to a treatment regimen for a TBI-associated impairment in the subject, using biomarkers (e.g., white blood cells indices (e.g., Neutrophil-Lymphocyte Ratio (NLR), absolute lymphocyte counts), sIL-6R, sgp130, IL-6, sgp130:sIL-6R ratio, sIL-2Ra, IL-2, sIL-2Ra:IL-2 ratio, TNFα, TNFRI, and TNFRI:TNFα ratio). |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135946 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1793 (20130101) Original (OR) Class A61K 47/6811 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/5412 (20130101) G01N 2333/7155 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20210227058 | Martinez-Heath et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); AT and T Intellectual Property II, L.P. (Atlanta, Georgia); AT and T Global Network Services France SAS (Courbevoie, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miguel Martinez-Heath (East Windsor, New Jersey); Keylor Eng (Seattle, Washington); Aurelien Bruno (Colomars, France); Scott Sayers (Jackson, New Jersey) |
| ABSTRACT | Fault-tolerant signaling in a Long Term Evolution (LTE) network architecture is disclosed. A method can comprise initiating a primary signaling path to a signaling server device; in response to the initiating, establishing an alternate signaling path to a web application server device, wherein a call session is established over the primary signaling path; monitoring the primary signaling path for a session failure; and in response to the session failure, switching the call session from using the primary signaling path to using the alternate signaling path. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/201806 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/22 (20130101) H04L 65/104 (20130101) H04L 65/1016 (20130101) H04L 65/1066 (20130101) H04L 69/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20210222263 | SHANKS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as Represented by the Administrator of the U.S. Environmental (Washington, District of Columbia); University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Government of the United States as Represented by the Administrator of the U.S. Environmental (Washington, District of Columbia); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Orin C. SHANKS (Lebanon, Ohio); Kyle J. BIBBY (Granger, Indiana); Elyse STACHLER (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods and reagents are used to determine the presence of human fecal contamination. These relate to detection of human crAssphage, a bacteriophage present in Bacteroides. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/201403 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20210224741 | Dearing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen M. Dearing (Herndon, Virginia); C. Scot Atkins (Chantilly, Virginia); James DeForrest Wilson (Collierville, Tennessee); Scott R. Bombaugh (Burke, Virginia); Carla F. Sherry (Annandale, Virginia) |
| ABSTRACT | Systems and methods for handling a plurality items by using a sorter to receive items and obtain item information and delivery destinations from the items. A run manifest is generated having an item identifier and a destination for each of the plurality of items. The run manifest data is used in a routing module to generate dynamic routes for delivering the plurality of items, and generating a sequence identifier for each of the plurality of items according to the dynamically generated routes. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/221578 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/00 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/08355 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20210222571 | Knortz |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. Knortz (West Hartford, Connecticut) |
| ABSTRACT | A rotor assembly is provided for a piece of rotational equipment. This rotor assembly includes a rotor disk, a rotor blade and a seal element. The rotor disk is configured to rotate about a rotational axis. The rotor blade includes an airfoil, a platform and a mount attaching the rotor blade to the rotor disk. The seal element is seated in a groove of the rotor disk. The seal element is configured to sealingly engage the platform and the mount. |
| FILED | Monday, January 20, 2020 |
| APPL NO | 16/747089 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/30 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/30 (20130101) F05D 2240/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222580 | Pratt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | United Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | William S. Pratt (West Hartford, Connecticut); Matthew E. Bintz (West Hartford, Connecticut); Weston Behling (Norwalk, Connecticut); Kevin N. McCusker (West Hartford, Connecticut); Erica J. Harvie (Middletown, Connecticut) |
| ABSTRACT | A rotor stack for a gas turbine engine includes a first rotor disk with a first rotor spacer arm, the first rotor spacer arm having a first flange with an outboard flange surface and an inboard flange surface, a first hole along an axis through the first flange, the first hole having a counterbore in the outboard flange surface; a second rotor disk with a web having a second hole along the axis; a third rotor disk with a third rotor spacer arm, the third rotor spacer arm having a third flange with an outboard flange surface and an inboard flange surface, a third hole along the axis through the third flange, the third hole having a counterbore in the inboard flange surface; and a bushing with a tubular body and a flange that extends therefrom, the tubular body comprising at least one axial groove along an outer diameter thereof, the bushing extends through the first hole, the second hole and partially into the counterbore in the inboard flange surface of the third hole. |
| FILED | Monday, January 20, 2020 |
| APPL NO | 16/747065 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/127 (20130101) Original (OR) Class F01D 25/12 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/18 (20130101) F02C 7/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210222587 | Cerino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph N. Cerino (Middletown, Connecticut); Andrew Yanaros (West Hartford, Connecticut); Paul W. Duesler (Manchester, Connecticut) |
| ABSTRACT | An assembly is provided for a turbine engine with an axial centerline. This assembly includes a turbine engine structure and a valve assembly. The turbine engine structure includes an outer duct wall, an inner duct wall, a first flow path and a second flow path. The inner duct wall is radially inward of the outer duct wall. The first flow path is radially inward of the inner duct wall. The second flow path is radially outward of the inner duct wall and is radially inward of the outer duct wall. The valve assembly includes a valve element and a valve actuator. The valve element is configured to regulate flow of fluid between the first flow path and the second flow path. The valve actuator is configured to move the valve element. The valve actuator is positioned entirely radially outward of the outer duct wall. |
| FILED | Monday, January 20, 2020 |
| APPL NO | 16/747330 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
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THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 22, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page