FedInvent™ Patent Applications
Patent Application Details for Thursday, July 29, 2021
This page was updated on Thursday, July 29, 2021 at 01:41 PM GMT
Department of Health and Human Services (HHS)
| US 20210227916 | Pan et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); BOISE STATE UNIVERSITY (Boise, Idaho) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); BOISE STATE UNIVERSITY (Boise, Idaho) |
| INVENTOR(S) | Christopher Pan (Morgantown, West Virginia); John Wu (Morgantown, West Virginia); Uwe Reischl (Boise, Idaho) |
| ABSTRACT | The present disclosure provides headgear protection systems for preventing or reducing work-related traumatic brain injury and/or risk. More particularly, the disclosure provides headgear systems having an air-bubble cushioning liner to improve shock absorption performance. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/160177 |
| CURRENT CPC | Hats; Head Coverings A42B 3/121 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228066 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiwen Liu (State College, Pennsylvania); Jian Yang (State College, Pennsylvania); Yizhu Chen (Fremont, California); Dingbowen Wang (State College, Pennsylvania) |
| ABSTRACT | A spectrally encoded fluorescence imaging system includes a multi-wavelength excitation light source emitting excitation light for illuminating a sample, optical components for introducing spectral encoding to focus different wavelengths of the excitation light at different positions in the sample to generate fluorescence at different, spatial positions, and band-shifting florescence imaging probes exhibiting excitation-dependent emission band, causing the fluorescence generated at different spatial positions to exhibit different band shifts, such that image information is encoded in the band-shifted fluorescence spectrums for parallel detection by a spectrometer or arrayed detectors operable to resolve different wavelengths. |
| FILED | Tuesday, July 30, 2019 |
| APPL NO | 17/264161 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/043 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 49/006 (20130101) A61K 49/0021 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 2021/6419 (20130101) G01N 2021/6421 (20130101) G01N 2021/6423 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228078 | Miyaoka et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Robert S. Miyaoka (Seattle, Washington); Hubert Vesselle (Seattle, Washington); Robert Stewart (Seattle, Washington); Robert L. Harrison (Seattle, Washington); Larry A. Pierce, II (Seattle, Washington) |
| ABSTRACT | A garment for detecting radiation washout (e.g., radioactivity concentrations) in organs includes a covering that wraps around and is secured to the body. The covering permits positron emission tomography-computed tomography (PET/CT) imaging of the body through the covering. The garment includes guides formed from a material that is visible in a computed tomography (CT) image of the garment, such that the guides are visible in CT images of user organs that the garment overlies. A plurality of radiation detectors are attached to the covering in a configuration customized for the body. A wiring system connects the plurality of radiation detectors to a power and data control system that is configured to transmit data from the garment to a remote service provider. |
| FILED | Friday, May 10, 2019 |
| APPL NO | 17/045112 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/0024 (20130101) Original (OR) Class A61B 5/0033 (20130101) A61B 5/066 (20130101) A61B 5/6805 (20130101) Measurement of Nuclear or X-radiation G01T 1/02 (20130101) G01T 1/29 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228096 | Qin |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
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| INVENTOR(S) | Qin Qin (Ellicott City, Maryland) |
| ABSTRACT | The present invention is directed to a system and method for determining blood volume in a subject. Blood volume is an important hemodynamic parameter for monitoring many disorders, such as stoke and cancer. Current MRI techniques for quantification of absolute blood volume for such clinical applications all require injecting exogenous contrast agents. To reduce associated safety risks and cost, the present invention is directed to a non-contrast-enhanced MRI method for blood volume mapping on MRI. The technique of the present invention employs velocity-selective (VS) pulse trains in paired control and label modules for separating vascular signal by subtraction. The Fourier-transform based VS saturation pulse train (FT-VSS) of the present invention has improved performance over conventional VS pulse trains for the blood volume measurement. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161420 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/029 (20130101) Original (OR) Class A61B 5/055 (20130101) A61B 5/7257 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/448 (20130101) G01R 33/5618 (20130101) G01R 33/56518 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228143 | Yeh et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Fang-Cheng Yeh (Pittsburgh, Pennsylvania); Robert Max Friedlander (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described are a system, method, and computer program product for detecting neurodegeneration using differential tractography and treating neurological disorders accordingly. The method includes obtaining a first diffusion magnetic resonance imaging (MRI) scan of the brain of the patient and obtaining a plurality of diffusion MRI scans of a group of other brains. The method also includes generating a control diffusion MRI scan based on the plurality of diffusion MRI scans of the group of other brains. The method further includes determining a first anisotropy of first neural tracks of the first diffusion MRI scan and a second anisotropy of second neural tracks of the control diffusion MRI scan. The method further includes determining a differential by comparing the first anisotropy to the second anisotropy and identifying at least one neurological disorder based on the differential and a location of the first neural tracks in the brain of the patient. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/160433 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/4082 (20130101) Original (OR) Class A61B 2576/026 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) G01R 33/56341 (20130101) Image Data Processing or Generation, in General G06T 7/0014 (20130101) G06T 2207/10088 (20130101) G06T 2207/30016 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/70 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228144 | HERNANDEZ et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (MENANDS, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (, None); THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (, None) |
| INVENTOR(S) | GUILLERMO HORGA HERNANDEZ (Brooklyn, New York); CLIFFORD MILLS CASSIDY (Ottawa, Canada) |
| ABSTRACT | An exemplary system, method and computer-accessible medium for determining a dopamine function of a patient(s) can include, for example, receiving imaging information of a brain of the patient(s), determining a Neuromelanin (NM) concentration of the patient(s) based on the imaging information, and determining the dopamine function based on the NM concentration. The NM concentration can be determined using a voxel-wise analysis procedure. The voxel-wise analysis procedure can be used to determine a topographical pattern(s) within a substantia nigra (SN) of the brain of the patient(s). The topographical pattern(s) can include a pattern(s) of cell loss in the SN. The NM concentration can be based on a NM loss in the brain of the patient(s). |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226375 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/4082 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) G01R 33/4835 (20130101) Image Data Processing or Generation, in General G06T 7/0014 (20130101) G06T 7/60 (20130101) G06T 2207/10088 (20130101) G06T 2207/30016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228292 | TSAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Tsu-Chin TSAO (Los Angeles, California); Jean-Pierre HUBSCHMAN (Los Angeles, California); Cheng-Wei CHEN (Los Angeles, California); Yu-Hsiu LEE (Los Angeles, California); Matthew GERBER (Los Angeles, California) |
| ABSTRACT | A surgical system includes: (1) an imaging device configured to acquire imaging data of a surgical site; (2) a surgical manipulator configured to hold a surgical tool; and (3) a controller connected to the imaging device and the surgical manipulator, wherein the controller is configured to receive the imaging data from the imaging device and derive, from the imaging data, an insertion trajectory for the surgical tool through an incision at the surgical site. |
| FILED | Tuesday, May 14, 2019 |
| APPL NO | 17/052758 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/14 (20130101) A61B 34/10 (20160201) A61B 34/32 (20160201) Original (OR) Class A61B 2034/107 (20160201) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00736 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228296 | Dupont et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Pierre Dupont (Boston, Massachusetts); Karl Price (Boston, Massachusetts) |
| ABSTRACT | A robotic device comprising a support structure, a robotic arm coupled to the support structure and having a working channel extending from a proximal end to a distal end of the robotic arm, a drive system coupled to the support structure, and a tool module configured to detachably couple to the drive system, wherein the tool module comprises an elongate tool configured to be advanced through the working channel to a surgical site at the distal end of the robotic arm and subsequently removed from the robotic arm without having to withdraw the robotic arm from the surgical site, and a transmission configured to operatively connect the drive system and the elongate tool when the tool module is coupled with the drive system thereby providing for operation of the elongate tool by the drive system. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154577 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/30 (20160201) A61B 34/71 (20160201) Original (OR) Class A61B 2034/301 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228323 | Esquivel-Upshaw et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Josephine F. Esquivel-Upshaw (Gainesville, Florida); Fan Ren (Gainesville, Florida); Patrick Carey (Malden, Massachusetts); Arthur E. Clark, Jr. (Newberry, Florida); Christopher D. Batich (Gainesville, Florida) |
| ABSTRACT | Disclosed herein is a method for forming an anti-microbial layer on an apparatus. Also disclosed is a method for improving the anti-bacterial properties of a titanium device coated with titanium-nitride (TiN). Also disclosed is a medical apparatus comprising an anti-microbial layer prepared by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Wednesday, July 31, 2019 |
| APPL NO | 17/258022 |
| CURRENT CPC | Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 8/0013 (20130101) A61C 13/0835 (20130101) Original (OR) Class A61C 2201/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228327 | BASARA et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California); CARBON, INC. (REDWOOD CITY, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | NITASH P. BASARA (EL CERRITO, California); HEE JUENG OH (Berkeley, California); STEVEN W. HETTS (Hillsborough, California); MARIAM S. ABOIAN (SAN FRANCISCO, California); JOSEPH M. DESIMONE (REDWOOD CITY, California); GREGORY R. ROBBINS (REDWOOD CITY, California) |
| ABSTRACT | A chemical absorber to absorb and release compounds includes a porous scaffold of lattices, modified surfaces of the scaffold, wherein the modification is selected based upon an ability to bond with or release a particular compound, and a center hole in the scaffold to accommodate a guide wire. |
| FILED | Tuesday, April 30, 2019 |
| APPL NO | 17/051686 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/011 (20200501) A61F 2/0103 (20200501) Original (OR) Class A61F 2230/0067 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/262 (20130101) B01J 20/3007 (20130101) B01J 20/3285 (20130101) B01J 20/3289 (20130101) B01J 20/28042 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228404 | Maier et al. |
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| FUNDED BY |
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| APPLICANT(S) | Reia, LLC (Lyme, New Hampshire) |
| ASSIGNEE(S) | Reia, LLC (Lyme, New Hampshire) |
| INVENTOR(S) | Kaitlin E. Maier (Darien, Connecticut); Ariana M. Sopher (Somerville, Massachusetts); Meegan P. Daigler (Portland, Maine) |
| ABSTRACT | A pessary device has a support portion, a stem and a loop attached to the stem to facilitate manipulation and control of the pessary device. The loop portion is flexible and provides a hole for receipt of a finger of the person inserting or removing the pessary device. The loop portion preferably includes a taper and/or a dimpled end to facilitate the use of a finger or an applicator for insertion of the device deeper into the vagina. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/210576 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 6/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228481 | Popov et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexey Popov (Waltham, Massachusetts); Elizabeth M. Enlow (Waltham, Massachusetts); Hongming Chen (Belmont, Massachusetts); James Bourassa (Somerville, Massachusetts) |
| ABSTRACT | Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207442 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) Original (OR) Class A61K 9/5031 (20130101) A61K 9/5123 (20130101) A61K 9/5138 (20130101) A61K 9/5146 (20130101) A61K 31/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228482 | Popov et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexey Popov (Waltham, Massachusetts); Elizabeth M. Enlow (Waltham, Massachusetts); Hongming Chen (Belmont, Massachusetts); James Bourassa (Somerville, Massachusetts) |
| ABSTRACT | Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207467 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) Original (OR) Class A61K 9/5031 (20130101) A61K 9/5123 (20130101) A61K 9/5138 (20130101) A61K 9/5146 (20130101) A61K 31/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228493 | Farokhzad et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omid Farokhzad (Waban, Massachusetts); Jun Wu (Boston, Massachusetts); Lili Zhao (Boston, Massachusetts) |
| ABSTRACT | Cationic polymers are provided for delivering anionic active agents, preferably in the form or nanoparticles and other nanostructures. The polymer can be a polycation homopolymer or a copolymer containing a polycation block. The polycations and polycation containing polymers can contain dicarboxylic acid ester units and units of (α-amino acid)-α,ω-alkylene diester units. The nanoparticles can contain high loadings of anionic active agents, with sustained release of the active agents. Methods of making the polycations and polycation containing polymers are provided. Methods of making the nanoparticles and formulating them for administration to an individual in need thereof are also provided. |
| FILED | Monday, August 24, 2020 |
| APPL NO | 17/001237 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5073 (20130101) A61K 9/5078 (20130101) A61K 9/5153 (20130101) Original (OR) Class A61K 9/5192 (20130101) A61K 38/28 (20130101) A61K 38/38 (20130101) A61K 38/385 (20130101) A61K 47/60 (20170801) A61K 47/593 (20170801) A61K 47/645 (20170801) A61K 47/6931 (20170801) A61K 47/6937 (20170801) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 81/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228499 | Ji et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ru-Rong Ji (Durham, North Carolina); Sangsu Bang (Durham, North Carolina); Zhen-Zhong Xu (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are methods and compositions for treating a disease or disorder in a subject in need thereof. The methods may include administering to the subject a therapeutically effective amount of a GPR37 agonist. The disease or disorder may be selected from inflammation, inflammatory pain, chronic pain, viral infection, bacterial infection, malaria, sepsis, or a combination thereof. |
| FILED | Tuesday, June 04, 2019 |
| APPL NO | 15/734543 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) Original (OR) Class A61K 31/202 (20130101) A61K 31/352 (20130101) A61K 31/357 (20130101) A61K 38/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228500 | GOLCZAK et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESRVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcin Bernard GOLCZAK (Cleveland, Ohio); Josie Ann SILVAROLI (Cleveland, Ohio) |
| ABSTRACT | A method of treating an ocular, inflammatory, immune, and/or metabolic disorder in a subject in need thereof includes administering to the subject a therapeutically effective amount of a compound having a structure of formula (I). |
| FILED | Friday, June 07, 2019 |
| APPL NO | 15/734781 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228518 | Kadam |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); KENNEDY KRIEGER INSTITUTE, INC. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shilpa D. Kadam (Pikesville, Maryland) |
| ABSTRACT | The present invention relates to the field of seizures. More specifically, the present invention provides compositions and methods for treating refractory seizures in neonates. In one embodiment, the method comprises the steps of (a) administering to the patient an amount of a KCC2 agonist and/or trkB antagonist effective to restore KCC2 expression to normal physiological levels; and (b) administering to the patient an effective amount of an anti-seizure medication. |
| FILED | Tuesday, September 08, 2020 |
| APPL NO | 17/014220 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2207/20 (20130101) A01K 2207/30 (20130101) A01K 2267/0356 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/196 (20130101) Original (OR) Class A61K 31/501 (20130101) A61K 31/515 (20130101) A61K 31/553 (20130101) A61K 31/4015 (20130101) A61K 31/4166 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228519 | Huang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADS (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yadong Huang (Daville, California); Alice Taubes (San Francisco, California); Phil Nova (San Francisco, California); Marina Sirota (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods of treating Alzheimer's Disease (AD) and rescuing cognitive deficits associated with AD in a subject having an apoE4/4 genotype, by administering a therapeutically effective amount of the loop-diuretic bumetanide to the subject. Also disclosed are kits for performing the method, including one or more doses of a bumetanide formulation; and which may also include instructions for treating a patient having an apoE4/4 genotype by administering bumetanide, and/or instructions and reagents for testing/identifying a subject having an apoE4/4 genotype. |
| FILED | Friday, April 12, 2019 |
| APPL NO | 17/046950 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 9/7023 (20130101) A61K 31/196 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228539 | Corson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy William Corson (Fishers, Indiana); Rania Sulaiman (Indianapolis, Indiana) |
| ABSTRACT | Methods of using compounds to inhibit ocular disease are disclosed herein. Methods are disclosed for inhibiting soluble epoxide hydrolase (sEH) for the treatment of ocular diseases, and in particular, wet age-related macular degeneration (AMD). |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226814 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 9/0053 (20130101) A61K 31/192 (20130101) A61K 31/353 (20130101) Original (OR) Class A61K 31/423 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228549 | Wrobel et al. |
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| FUNDED BY |
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| APPLICANT(S) | Biohaven Therapeutics Ltd. (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Edward Wrobel (Lawrenceville, New Jersey); Allen B. Reitz (Lansdale, Pennsylvania); Jeffrey Claude Pelletier (Lafayette Hill, Pennsylvania); Garry Robert Smith (Royersford, Pennsylvania); Haiyan Bian (Princeton, New Jersey) |
| ABSTRACT | Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process. |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/151585 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/006 (20130101) A61K 9/1617 (20130101) A61K 9/2004 (20130101) A61K 31/428 (20130101) Original (OR) Class A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/5377 (20130101) A61K 38/05 (20130101) A61K 38/06 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 277/82 (20130101) C07D 417/12 (20130101) Peptides C07K 5/0806 (20130101) C07K 5/0808 (20130101) C07K 5/0812 (20130101) C07K 5/06026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228591 | Pak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Pak (St. Louis, Missouri); David Perlmutter (St. Louis, Missouri); Gary Silverman (St. Louis, Missouri) |
| ABSTRACT | The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents. |
| FILED | Friday, April 19, 2019 |
| APPL NO | 17/048957 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/135 (20130101) A61K 31/138 (20130101) A61K 31/155 (20130101) A61K 31/444 (20130101) A61K 31/505 (20130101) A61K 31/4418 (20130101) A61K 31/4453 (20130101) A61K 31/5355 (20130101) A61K 31/5415 (20130101) Original (OR) Class A61K 31/7135 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228608 | BAASOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Technion Research and Development Foundation Limited (Haifa, Israel) |
| ASSIGNEE(S) | Technion Research and Development Foundation Limited (Haifa, Israel) |
| INVENTOR(S) | Timor BAASOV (Haifa, Israel); Dana ATIA-GLIKIN (Schania, Israel); Jeyakumar KANDASAMY (Trichy, India); Valery BELAKHOV (Haifa, Israel) |
| ABSTRACT | A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5″ position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/226050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7036 (20130101) Original (OR) Class A61K 45/06 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 79/00 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 5/06 (20130101) C07H 13/04 (20130101) C07H 15/23 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228618 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GLYCOMIRA THERAPEUTICS, INC. (SALT LAKE CITY, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Won Yong LEE (Bountiful, Utah); Abigail Pulsipher (Salt Lake City, Utah); Thomas P. Kennedy (Charlotte, North Carolina); Justin Rodney Savage (North Salt Lake, Utah); Glenn Prestwich (Spokane, Washington) |
| ABSTRACT | Described herein are methods for preventing a serious health consequence and/or tissue damage in a subject after the subject has been exposed to ionizing radiation and/or chemotherapy. The methods involve administering to the subject a sulfated polysaccharide or the pharmaceutically acceptable salt or ester thereof after the subject has been exposed to ionizing radiation and/or chemotherapy. The methods described herein are most beneficial to cancer patients who suffer from mucositis after exposure to ionizing radiation. |
| FILED | Monday, June 03, 2019 |
| APPL NO | 17/059982 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) Original (OR) Class A61K 31/728 (20130101) A61K 31/737 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228652 | Nakatsuji et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Teruaki Nakatsuji (San Diego, California); Richard L. Gallo (San Diego, California) |
| ABSTRACT | Methods and compositions comprising hogocidin peptides (SH-lantibiotics), derivatives and variants are provided. Also provided are methods and compositions comprising probiotic compositions utilizing strains of S. hominis and S. epidermidis that produce hogocidin, hogocidin-like peptides, or other inhibitors of skin pathogens. Methods of treatment for microbial skin infections and atopic dermatitis are also provided. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/220308 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) A61K 9/14 (20130101) A61K 35/741 (20130101) Original (OR) Class A61K 35/744 (20130101) A61K 38/164 (20130101) A61K 38/1729 (20130101) A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101) A61P 31/04 (20180101) Peptides C07K 14/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228655 | O'Toole et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); Dartmouth-Hitchcock Clinic (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George A. O'Toole (Hanover, New Hampshire); Juliette C. Madan (Lyme, New Hampshire) |
| ABSTRACT | The present disclosure relates to a method of altering intestinal microbiome in a patient having cystic fibrosis comprising administering at least one of Bifidobacterium and/or Bacteroides to a patient and allowing the Bifidobacterium and/or Bacteroides to alter the intestinal microbiome. |
| FILED | Tuesday, March 26, 2019 |
| APPL NO | 16/979824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 35/744 (20130101) A61K 35/745 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228664 | Archibong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Meharry Medical College (Nashville, Tennessee) |
| ASSIGNEE(S) | Meharry Medical College (Nashville, Tennessee) |
| INVENTOR(S) | Anthony E. Archibong (Antioch, Tennessee); Bindong Liu (Brentwood, Tennessee); G. William Bates (Brentwood, Tennessee); Elochukwu J. Ezekakpu (Nashville, Tennessee); Lorin W. Simon (Antioch, Tennessee); James E.K. Hildreth (Nashville, Tennessee) |
| ABSTRACT | Artificial cervical fluid is disclosed that contains a mucilaginous extract from the okra plant. The mucilaginous extract can be produced using a hot aqueous extractant or cold extraction process followed by separation of larger particles from the extract. The extract finds many uses, for example as a sperm storage medium, a sperm freezing medium, a sexual lubricant, an artificial insemination medium, an in vitro fertilization medium, and methods for treating and/or preventing infection, replication, and transmission of viruses, such as sexually transmitted viruses. |
| FILED | Sunday, March 21, 2021 |
| APPL NO | 17/207677 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Diagnosis; Surgery; Identification A61B 17/43 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 9/0036 (20130101) A61K 9/0053 (20130101) A61K 36/185 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2236/39 (20130101) A61K 2236/53 (20130101) A61K 2236/331 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228672 | Xing et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KUALITY HERBCEUTICS LLC (Gainesville, Florida) |
| ASSIGNEE(S) | KUALITY HERBCEUTICS LLC (Gainesville, Florida) |
| INVENTOR(S) | Chengguo Xing (Gainesville, Florida); Stephen Hecht (St. Paul, Minnesota); Junxuan Lu (Hershey, Pennsylvania); Pramod Upadhyaya (Atlanta, Georgia); Sharon Murphy (St. Paul, Minnesota); Pablo Leitzman (Minneapolis, Minnesota); Sreekanth Narayanapillai (St. Paul, Minnesota); Silvia Balbo (St. Paul, Minnesota) |
| ABSTRACT | Certain embodiments of the invention provide a composition comprising at least two compounds selected from the group consisting of dihydromethysticin, methysticin, dihydrokavain, kavain, desmethoxyyangonin and 11-methoxyyangonin, wherein the composition is substantially free of flavokawain B. Certain embodiments of the invention also provide a method for treating or preventing cancer in a mammal (e.g., a human) in need of such treatment comprising, administering to the mammal a carrier and a compound selected from the group consisting of dihydromethysticin, methysticin, dihydrokavain, kavain, desmethoxyyangonin and 11-methoxyyangonin, wherein the compound is substantially free of other kava extract components. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/141313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/353 (20130101) A61K 31/366 (20130101) A61K 36/67 (20130101) Original (OR) Class A61K 2236/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228699 | Novina et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Carl Novina (Newton, Massachusetts); Robert Distel (Framingham, Massachusetts); Alberto Nobili (Brookline, Massachusetts); Steven Neier (Waltham, Massachusetts) |
| ABSTRACT | The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers. |
| FILED | Tuesday, June 04, 2019 |
| APPL NO | 15/734116 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/1774 (20130101) A61K 39/0013 (20130101) Original (OR) Class A61K 39/385 (20130101) A61K 41/0042 (20130101) A61K 41/0057 (20130101) A61K 45/06 (20130101) A61K 47/545 (20170801) A61K 47/555 (20170801) A61K 47/6889 (20170801) A61K 47/6897 (20170801) A61K 2035/124 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228706 | Ravetch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Jeffrey V. Ravetch (New York, New York); Taia Wang (New York, New York); Jad Mamaary (New York, New York) |
| ABSTRACT | The present invention relates to immunogenic immune complexes, related compositions, and related methods. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/301626 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/12 (20130101) A61K 39/42 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2039/5252 (20130101) A61K 2039/55516 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) A61P 35/00 (20180101) Peptides C07K 14/005 (20130101) C07K 14/4748 (20130101) C07K 16/1018 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/41 (20130101) C07K 2317/72 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228716 | Bakaletz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| INVENTOR(S) | Lauren O. Bakaletz (Hilliard, Ohio); Steven D. Goodman (Hilliard, Ohio) |
| ABSTRACT | This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that are released from the biofilm by our technology are more readily cleared by the remainder of the host's immune system. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150731 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/64 (20130101) A61K 39/12 (20130101) A61K 39/40 (20130101) Original (OR) Class A61K 39/395 (20130101) A61K 2039/507 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 29/16 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 11/00 (20130101) A61Q 17/005 (20130101) Peptides C07K 16/12 (20130101) C07K 16/18 (20130101) C07K 16/1217 (20130101) C07K 16/1232 (20130101) C07K 16/1242 (20130101) C07K 16/1271 (20130101) C07K 16/1275 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228733 | Khaled et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Annette Khaled (Orlando, Florida); Jesus Manuel Perez Figueroa (Los Angeles, California); Santimukul Santra (Pittsburg, Kansas); Charalambos Kaittanis (Cambridge, Massachusetts); Oscar Santiesteban (El Segundo, California); Jan Grimm (Larchmont, New York); Hampton Sessions (Orlando, Florida) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida); Sanford Burnham Prebys Medical Discovery Institute at Lake Nona (Orlando, Florida); Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Annette Khaled (Orlando, Florida); Jesus Manuel Perez Figueroa (Los Angeles, California); Santimukul Santra (Pittsburg, Kansas); Charalambos Kaittanis (Cambridge, Massachusetts); Oscar Santiesteban (El Segundo, California); Jan Grimm (Larchmont, New York); Hampton Sessions (Orlando, Florida) |
| ABSTRACT | Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228286 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 45/06 (20130101) A61K 47/6869 (20170801) Original (OR) Class A61K 47/6935 (20170801) A61K 51/1072 (20130101) A61K 51/1244 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228740 | Hinderer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Hinderer (New Orleans, Louisiana); James M. Wilson (Philadelphia, Pennsylvania) |
| ABSTRACT | A suspension useful for AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDUA gene is provided herein. Also provided are methods and kits containing these vectors and compositions useful for treating MPSI and the symptoms associated with Hurler, Hurler-Scheie and Scheie syndromes. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/201301 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) C12N 15/86 (20130101) C12N 15/8645 (20130101) C12N 2750/14143 (20130101) C12N 2830/15 (20130101) Enzymes C12Y 302/01076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228741 | REH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (SEATTLE, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (SEATTLE, Washington) |
| INVENTOR(S) | Thomas A. REH (SEATTLE, Washington); Nikolas L. JORSTAD (SEATTLE, Washington); Stefanie G. WOHL (SEATTLE, Washington) |
| ABSTRACT | Methods and compositions are provided for regeneration of retinal neurons and vision restoration after injury, disease, or loss comprising, administration of a nucleic acid sequence encoding Ascl1 and retinal reprogramming potentiating agents, including HDAC inhibitors, STAT-signaling inhibitors and microRNA manipulations in Ascl1-induced retinal regeneration. |
| FILED | Monday, April 29, 2019 |
| APPL NO | 17/050999 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/80 (20130101) C12N 15/113 (20130101) C12N 2310/141 (20130101) Enzymes C12Y 305/01098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228742 | MIAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital D/B/A Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Carol Hsing MIAO (Seattle, Washington); David J. RAWLINGS (Seattle, Washington); Chong LI (Seattle, Washington) |
| ABSTRACT | Methods, compositions, and systems for treating subject(s) in need of plasma Factor VIII, particularly a subject having preexisting anti-FVIII inhibitory antibodies, are provided. The methods involve administering to the subject a therapeutically effective amount of an inflammation suppressor, a therapeutically effective amount of a CD8+ T cell depleting agent, and a therapeutically effective amount of a composition comprising a lentiviral vector (LV) comprising an optimized FVIII expression cassette expressibly linked to a megakaryocyte-specific promoter. Such methods, compositions, and systems are useful to treat subjects with blood clotting disorder(s), such as hemophilia A. |
| FILED | Friday, April 26, 2019 |
| APPL NO | 17/051137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) A61K 39/3955 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) Peptides C07K 16/2815 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228743 | KASPAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio); OHIO STATE INNOVATIONFOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian K. KASPAR (Columbus, Ohio); Arthur BURGHES (Columbus, Ohio); Paul PORENSKY (Columbus, Ohio) |
| ABSTRACT | The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-os-molar contrast agent, together with a rAA9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/206878 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 48/00 (20130101) A61K 48/0008 (20130101) A61K 48/0075 (20130101) Original (OR) Class A61K 49/0438 (20130101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228747 | Baranowska-Kortylewicz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janina Baranowska-Kortylewicz (Omaha, Nebraska); Zbigniew Kortylewicz (Omaha, Nebraska) |
| ABSTRACT | Compositions and methods for treating, detecting, and diagnosing cancer are disclosed. |
| FILED | Thursday, April 04, 2019 |
| APPL NO | 16/967527 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/037 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/4184 (20130101) A61K 51/0453 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1007 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 235/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228771 | AKKUS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ozan AKKUS (Cleveland Heights, Ohio); Adonis HIJAZ (Westlake, Ohio) |
| ABSTRACT | A biologic material is disclosed. The biologic material comprises a crosslinked structural protein and macrophages seeded on the crosslinked structural protein. A method of use of the biologic material for an immunoregenerative treatment in a patient in need thereof also is disclosed. The method comprises steps of: (1) seeding the macrophages on the crosslinked structural protein, thereby obtaining the biologic material; and (2) implanting the biologic material into the patient. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/158424 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) A61L 27/52 (20130101) A61L 27/222 (20130101) A61L 27/225 (20130101) A61L 27/227 (20130101) Original (OR) Class A61L 27/3683 (20130101) A61L 2430/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228774 | Shea et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lonnie D. Shea (Ann Arbor, Michigan); Richard Youngblood (Ann Arbor, Michigan); Tadas Kaspuyis (Ann Arbor, Michigan) |
| ABSTRACT | An in vitro method of preparing insulin-producing cell clusters for transplantation into a subject, comprising (a) seeding pancreatic progenitor cells onto a three-dimensional, porous scaffold at a seeding density greater than about 12.5 million cells per cm3 of scaffold and less than about 150 million cells per cm3 of scaffold, wherein the scaffold comprises a plurality of pores having an average pore diameter greater than about 225 μm and less than about 550 pm, and (b) culturing the cells on the scaffold for more than about 3 days in culture medium to obtain insulin-producing cell clusters within the pores of the scaffold for transplantation into a subject. In exemplary aspects, the pancreatic progenitor cells are cells derived from pluripotent stem cells. |
| FILED | Tuesday, May 21, 2019 |
| APPL NO | 17/056848 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/3633 (20130101) A61L 27/3834 (20130101) Original (OR) Class A61L 27/3895 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0677 (20130101) C12N 5/0678 (20130101) C12N 2513/00 (20130101) C12N 2533/30 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228792 | POTKAY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph POTKAY (Plymouth, Michigan); Robert H. BARTLETT (Ann Arbor, Michigan); Alvaro ROJAS-PENA (Ann Arbor, Michigan) |
| ABSTRACT | An artificial lung system for a patient having a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust; a gas system operably coupled to the gas inlet of the membrane lung system; a gas phase CO2 sensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas CO2 (EGCO2) level and/or an blood oxygen saturation sensor disposed upstream of the blood inlet of the membrane lung system and monitoring a blood oxygen saturation level; and a feedback controller receiving the CO2 signal and/or blood oxygen saturation signal and outputting a control signal to control gas flow and/or blood flow. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/054909 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1603 (20140204) A61M 1/1698 (20130101) Original (OR) Class A61M 1/3638 (20140204) A61M 2205/3327 (20130101) A61M 2205/3334 (20130101) A61M 2230/202 (20130101) A61M 2230/205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210228880 | Machado et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andre Machado (Pepper Pike, Ohio); Raghavan Gopalakrishnan (Brecksville, Ohio); Kenneth Baker (Chesterland, Ohio) |
| ABSTRACT | Deep brain stimulation (DBS) can be used to treat many neurological conditions beyond traditional movement disorders. When patients do not suffer from traditional movement disorders, medical professionals cannot use traditional observation-based methods to configure the DBS system. A new method for selecting stimulation configurations can include recording internal data and external data as the patient performs (or attempts to perform) a motor task. The internal data is electrophysiology data recorded by a plurality of DBS electrodes, used to identify at least one of the plurality of electrodes closest to a neuronal population involved in control of the at least one motor task. The external data is electroencephalogram (EEG) data recorded by scalp electrodes, which is used to select at least one of the potential stimulation electrodes to deliver the DBS. When the electrode(s) delivering the DBS are selected, optimal parameters for the DBS are then chosen. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154045 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0534 (20130101) A61N 1/36067 (20130101) Original (OR) Class A61N 1/36135 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229038 | Roy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shuvo Roy (San Ramon, California); Benjamin W. Chui (Sunnyvale, California); Nathan Wright (San Francisco, California) |
| ABSTRACT | Filtration membrane with improved mechanical stability and increased resistance to pressure is provided. The filtration membrane is useful for in vivo implantable filtration devices, such as, an artificial kidney. In vivo implantable filtration devices are also provided. |
| FILED | Friday, May 17, 2019 |
| APPL NO | 17/055326 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/16 (20130101) Separation B01D 61/18 (20130101) B01D 61/28 (20130101) Original (OR) Class B01D 69/02 (20130101) B01D 2221/10 (20130101) B01D 2323/28 (20130101) B01D 2325/08 (20130101) B01D 2325/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229364 | McLeod et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert R. McLeod (Boulder, Colorado); Camila Uzcategui (Boulder, Colorado); John Elliott Hergert (Boulder, Colorado); Archish Muralidharan (Boulder, Colorado) |
| ABSTRACT | Stereolithography with micron scale control of properties is described herein. In one aspect, a computer-implemented method for 3-D printing of a material can include generating a functional relation predicting one or more physical properties of the material resulting from printing parameters; algebraically or numerically solving the functional relation to generate a second functional relation predicting expected printing parameters resulting in the one or more physical properties; and printing the material via a photopolymerization printer according to the set of printing parameters determined by the second functional relation. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149423 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/264 (20170801) B29C 64/393 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2023/0691 (20130101) B29K 2105/0002 (20130101) B29K 2105/24 (20130101) B29K 2995/0094 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/02 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230101 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Priscilla L. Yang (Boston, Massachusetts); Nathanael S. Gray (Boston, Massachusetts); Jaebong Jang (Seo-gu Daejeon, South Korea); Jinhua Wang (Winchester, Massachusetts); Nicholas Paul Kwiatkowski (Brookline, Massachusetts); Wenlong Lian (Lebanon, New Hampshire); Zhengnian Li (Allston, Massachusetts) |
| ABSTRACT | Provided herein are compounds, pharmaceutical compositions, methods, and kits for treating viral infections (e.g., Dengue viral infections). In certain embodiments, compounds useful in the methods described herein are of Formula (I) or (II). |
| FILED | Wednesday, May 15, 2019 |
| APPL NO | 17/055366 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Acyclic or Carbocyclic Compounds C07C 233/75 (20130101) Original (OR) Class C07C 255/44 (20130101) C07C 323/31 (20130101) C07C 2601/16 (20170501) Heterocyclic Compounds C07D 209/08 (20130101) C07D 213/65 (20130101) C07D 235/08 (20130101) C07D 295/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230121 | Katzenellenbogen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Katzenellenbogen (Urbana, Illinois); Seema K. Tiwari-Woodruff (Riverside, California); Sung Hoon Kim (Champaign, Illinois); Benita Katzenellenbogen (Urbana, Illinois) |
| ABSTRACT | 4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/054878 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 231/56 (20130101) Original (OR) Class C07D 409/04 (20130101) C07D 409/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230180 | Lindsley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig W. Lindsley (Brentwood, Tennessee); P. Jeffrey Conn (Nashville, Tennessee); Darren W. Engers (Brentwood, Tennessee); Katrina A. Bollinger (Murfreesboro, Tennessee); Julie L. Engers (Brentwood, Tennessee) |
| ABSTRACT | Described are positive allosteric modulators of muscarinic acetylcholine receptor M1 (mAChR M1), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof. |
| FILED | Thursday, February 16, 2017 |
| APPL NO | 15/998899 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) C07D 495/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230202 | Oscarson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); University College Dublin (Dublin, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan Oscarson (Dublin, Ireland); John Vincent Fahy (San Francisco, California); Irina Gitlin (San Francisco, California); Wilfred Raymond (San Francisco, California) |
| ABSTRACT | There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a dithiolsaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods. |
| FILED | Tuesday, September 10, 2019 |
| APPL NO | 17/270805 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/008 (20130101) A61K 9/0075 (20130101) A61K 9/0078 (20130101) A61K 47/26 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/12 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 5/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230215 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Christopher J. Chang (Berkeley, California); Shang Jia (Berkeley, California) |
| ABSTRACT | Proteins are labeled by contacting the protein with a thiophosphorodichloridate reagent under conditions to effect chemoselective histidine conjugation. |
| FILED | Saturday, March 20, 2021 |
| APPL NO | 17/207609 |
| CURRENT CPC | Peptides C07K 1/13 (20130101) Original (OR) Class C07K 1/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230219 | Morse et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona); UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Morse (Tampa, Florida); Josef Vagner (Tucson, Arizona); Mark McLaughlin (Tampa, Florida); Robert Gillies (Tampa, Florida); Amanda Huynh (Land O'Lakes, Florida); Michael Doligalski (Lutz, Florida) |
| ABSTRACT | Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation. |
| FILED | Monday, October 05, 2020 |
| APPL NO | 17/063158 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0019 (20130101) A61K 49/0032 (20130101) A61K 49/0052 (20130101) A61K 51/0497 (20130101) Peptides C07K 5/081 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230229 | CHURCH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | George M. CHURCH (Brookline, Massachusetts); Eric KELSIC (Cambridge, Massachusetts); Pierce OGDEN (Cambridge, Massachusetts); Sam SINAI (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein provides viral capsid polypeptides bearing mutations that alters tissue tropism of a virus comprising the viral capsid polypeptide. In various embodiments, tissue tropisim to the heart, kidney, liver, lung, spleen, or blood is altered. |
| FILED | Wednesday, May 08, 2019 |
| APPL NO | 17/055318 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230230 | Broder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland) |
| ASSIGNEE(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland) |
| INVENTOR(S) | Christopher C. Broder (Silver Spring, Maryland); Katharine N. Bossart (San Francisco, California) |
| ABSTRACT | This invention relates to soluble forms of G glycoprotein from Hendra and Nipah virus. In particular, this invention relates to compositions comprising soluble forms of G glycoprotein from Hendra and Nipah virus and also to diagnostic and therapeutic methods using the soluble forms of G glycoprotein from Hendra and Nipah virus. Further, the invention relates to therapeutic antibodies including neutralizing antibodies, and vaccines for the prevention and treatment of infection by Hendra and Nipah viruses. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/161720 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/12 (20130101) A61K 39/155 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/07 (20130101) C07K 14/115 (20130101) C07K 16/1027 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230231 | Dudman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Howard Hughes Medical Institute (Chevy Chase, Maryland); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Dudman (Leesburg, Virginia); Adam Hantman (Ashburn, Virginia); Bum-Yeol Hwang (Moraga, California); Alla Karpova (Ashburn, Virginia); Loren Looger (Sterling, Virginia); Kimberly Ritola (Ashburn, Virginia); David Schaffer (Danville, California); Dougal Gowanlock Robinson Tervo (Ashburn, Virginia); Sarada Viswanathan (Ashburn, Virginia) |
| ABSTRACT | The present disclosure provides AAV variants that exhibit a preference for retrograde movement in neurons and methods of using such variants. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209336 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/005 (20130101) C07K 14/015 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14145 (20130101) C12N 2810/6027 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/06 (20130101) C40B 40/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230254 | Scheid et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Johannes Scheid (New York, New York); Michel Nussenzweig (New York, New York); Pamela J. Bjorkman (Altadena, California); Ron Diskin (Rehovot, Israel) |
| ABSTRACT | The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/248143 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/1045 (20130101) Original (OR) Class C07K 16/1063 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230258 | Kurtis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Kurtis (Providence, Rhode Island); Dipak K. Raj (Providence, Rhode Island); Alok Das Mohapatra (Providence, Rhode Island); Jenna Zuromski (Providence, Rhode Island) |
| ABSTRACT | Provided herein are methods, compositions and kits for preventing and treating malaria. Also included herein are kits for preventing and treating malaria. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/146423 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) Peptides C07K 16/205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230268 | Hendifar |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| INVENTOR(S) | Andrew Hendifar (Santa Monica, California) |
| ABSTRACT | A composition for IL-1 inhibition in combination with cancer therapies (e.g., chemotherapeutics including chemotherapy protective drugs) is provided for use in treating pancreatic cancer cachexia in patients, so as to reduce weight loss and improve the quality of life and survival of the patients. In one embodiment, the IL-1 inhibitor is an antibody, such as bermekimab, anakinra, canakinumab, gevokizumab, or rilonacept, administered simultaneously or sequentially with iritenocan, 5-fluorouracil and folinic acid to a pancreatic cancer patient. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/4745 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230275 | Pardoll et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); St. Jude's Children's Research Hospital, Inc. (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Drew Pardoll (Brookeville, Maryland); Ching-Tai Huang (Taipei, Taiwan); Jonathan Powell (Baltimore, Maryland); Charles G. Drake (Baltimore, Maryland); Dario A. Vignali (Pittsbugh, Pennsylvania); Creg J. Workman (Memphis, Tennessee) |
| ABSTRACT | Combinations of anti-cancer antibodies and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The inhibitory antibodies may be generated in an animal by injection of fragments of CD223. Antibodies may be monoclonal antibodies or single chain antibodies or humanized antibodies. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/155228 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) A01K 67/0276 (20130101) A01K 2267/0381 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/001129 (20180801) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 2035/122 (20130101) Peptides C07K 14/70503 (20130101) C07K 16/18 (20130101) C07K 16/42 (20130101) C07K 16/2803 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230279 | Nishimura et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen L. Nishimura (San Francisco, California); Jianlong Lou (San Francisco, California); James D. Marks (San Francisco, California); Jody L. Baron (San Francisco, California); Yifan Cheng (San Francisco, California); Shenping Wu (San Francisco, California); Anthony Cormier (San Francisco, California); Naoki Takasaka (San Francisco, California) |
| ABSTRACT | New antibodies and methods of use are described. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/155784 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/04 (20180101) A61P 31/20 (20180101) A61P 35/04 (20180101) A61P 37/04 (20180101) Peptides C07K 14/705 (20130101) C07K 16/22 (20130101) C07K 16/2839 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/563 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230313 | DeAngelis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Oklahoma City, Oklahoma); Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul L. DeAngelis (Edmond, Oklahoma); Dixy E, Green (Edmond, Oklahoma); Robert J. Linhardt (Albany, New York); Xing Zhang (Albany, New York); Victor Schuitz (Gloversville, New York) |
| ABSTRACT | Described herein are sulfur-containing glycosaminoglycans, and methods of making and using them. For example, heparosan and hyaluronan analogs are described which incorporate one or more sulfur-containing sugar units that include one or more free sulfhydryls and/or one or more thio-glycosidic linkages. In some embodiments, the glycosaminoglycans are included in pharmaceutical or bioadhesive compositions. |
| FILED | Friday, May 24, 2019 |
| APPL NO | 15/734499 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/61 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/08 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0072 (20130101) C08B 37/0075 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/04 (20130101) C12P 19/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230343 | Langer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Biocant-Center of Innovation and Biotechnology (Cantanhede, Portugal) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert S. Langer (Newton, Massachusetts); Jeffrey M. Karp (Chestnut Hill, Massachusetts); Maria Jose Maio Nunes-Pereira (Lisbon, Portugal); Ben Ouyang (Toronto, Canada); Lino da Silva Ferreira (Coimbra, Portugal); Debanjan Sarkar (Williamsville, New York) |
| ABSTRACT | Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185528 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/703 (20130101) A61K 9/7084 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/14 (20130101) C08G 18/4236 (20130101) Original (OR) Class C08G 18/4238 (20130101) C08G 18/4283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230527 | Vunjak-Novakovic et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gordana Vunjak-Novakovic (New York, New York); Keith Yeager (Springfield, New Jersey); Kacey Ronaldson (New York, New York) |
| ABSTRACT | An integrated modular microphysiological system is provided which includes a two or more chambers and a vascular network which includes at least one channel. The chamber can be configured for culturing a tissue and includes a layer of endothelial cells which forms an endothelial barrier within the well. The endothelial barrier can be in fluid contact with at least one of the at least one channels in the vascular network. The endothelial barrier can also be in fluid contact with a fluid in the chamber. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/159037 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/44 (20130101) C12M 27/16 (20130101) C12M 29/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230538 | Theunissen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Thorold W. Theunissen (Belmont, Massachusetts); Nathanael S. Gray (Boston, Massachusetts); Rudolf Jaenisch (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure provides compounds of any one of Formulae (A) to (L). The present disclosure also provides compositions, uses, and methods that include or involve a compound described herein, a serine/threonine-protein kinase B-Raf (BRAF) inhibitor, an epidermal growth factor receptor (EGFR) inhibitor, a vascular endothelial growth factor 1 (VEGFR1) inhibitor, a fibroblast growth factor receptor 1 (FGFR1) inhibitor, or a combination thereof. The compounds, compositions, uses, and methods are useful in changing the pluripotency state of a vertebrate cell to a more nave state. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/071627 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) Original (OR) Class C12N 5/0696 (20130101) C12N 2501/11 (20130101) C12N 2501/115 (20130101) C12N 2501/165 (20130101) C12N 2501/727 (20130101) C12N 2501/999 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230545 | Zebley et al. |
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| FUNDED BY |
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| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| INVENTOR(S) | Caitlin Zebley (Memphis, Tennessee); Hossam Abdelsamed (Pittsburgh, Pennsylvania); Benjamin Youngblood (Memphis, Tennessee) |
| ABSTRACT | Provided herein are methods and compositions for modulating T-cell activity by incubating a CD8 T cell with a signal 3 cytokine, such as IL-12. Incubation of naïve CD8 T cells, particularly, with a signal 3 cytokine can acquire long-lived memory associated gene expression characteristic of the stem cell memory subset of CD8 T cells. Further, incubation with signal 3 cytokines can induce changes to the epigenetic profile of naïve CD8 T cells that are more characteristic of bona fide Tscm cells than in vitro generated cells using traditional differentiation protocols. On account of epigenetic profiles being preserved during in vivo homeostasis, signal 3 cytokines such as IL-12 can be used to engineer a T cell population with the desired epigenetic profile that maintains effector functions and proliferative capacity. |
| FILED | Monday, July 08, 2019 |
| APPL NO | 17/258533 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/7051 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 2501/51 (20130101) C12N 2501/515 (20130101) C12N 2501/998 (20130101) C12N 2501/2312 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230576 | MARSHALL et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purigen Biosystems, Inc. (Pleasanton, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lewis A. MARSHALL (Oakland, California); Amy L. HIDDESSEN (Pleasanton, California); Nathan P. HOVERTER (Pleasanton, California); Klint A. ROSE (Oakland, California); Juan G. SANTIAGO (Stanford, California); Matthew S. MUNSON (Evanston, Illinois); Janine MOK (Palo Alto, California); Sean ARIN (Oakland, California); Yatian QU (Sunnyvale, California); Andrew LEE (Hayward, California); Michael Christopher De Renzi (Pleasanton, California) |
| ABSTRACT | The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230582 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 3/502761 (20130101) B01L 3/502776 (20130101) B01L 9/527 (20130101) B01L 2200/0621 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/101 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44717 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230588 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harwar College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Seth Lawler Shipman (Boston, Massachusetts); Jeffrey D. Manklis (Brookline, Massachusetts); Jeffrey Matthew Nivala (Allston, Massachusetts) |
| ABSTRACT | This invention provides methods of altering a cell including providing the cell with a nucleic acid sequence encoding a Cas1 protein and/or a Cas2 protein of a CRISPR adaptation system, providing the cell with a CRISPR array nucleic acid sequence including a leader sequence and at least one repeat sequence, wherein the cell expresses the Cas1 protein and/or the Cas2 protein and wherein the CRISPR array nucleic acid sequence is within genomic DNA of the cell or on a plasmid. Also provided are methods and systems for nucleic acid storage and in vivo molecular recordings of events into a cell. |
| FILED | Thursday, February 16, 2017 |
| APPL NO | 15/999616 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/122 (20130101) Computer Systems Based on Specific Computational Models G06N 3/123 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230592 | Scheinberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | David A. Scheinberg (New York, New York); Michael R. McDevitt (Bronx, New York); Carlos H. Villa (Philadelphia, Pennsylvania); J. Justin Mulvey (New York, New York) |
| ASSIGNEE(S) | Sloan-Kettering Institute for Cancer Research (New York, New York) |
| INVENTOR(S) | David A. Scheinberg (New York, New York); Michael R. McDevitt (Bronx, New York); Carlos H. Villa (Philadelphia, Pennsylvania); J. Justin Mulvey (New York, New York) |
| ABSTRACT | Provided herein are single wall nanotube constructs to which are convalently linked a plurality of a bifunctional chelator, a therapeutic or a diagnostic radionuclide chelated to each bifunctional chelator and a plurality of morpholino oligonucleotides conjugated to the single wall nanotube. Also provided are single wall nanotube complexes which have the morpholino oligonucleotides on the single wall nanotube constructs hybridized to other morpholino oligonucleotides. The other morpholino oligonucleotides are each conjugated to a therapeutic antibody. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/158132 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6849 (20170801) A61K 51/1027 (20130101) A61K 51/1093 (20130101) A61K 51/1203 (20130101) A61K 51/1248 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 16/30 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) C07K 2317/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/351 (20130101) C12N 2310/3233 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230593 | HAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Si-ping HAN (Duarte, California); William A. GODDARD, III (Pasadena, California); Marwa Ben HAJ SALAH (Duarte, California); Lisa SCHERER (Duarte, California); John J. ROSSI (Duarte, California) |
| ABSTRACT | Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents. The Cond-siRNA comprises a sensor strand, a core strand, and a guide strand, which crossover to form a sensor duplex and a RNAi duplex attached to each other to form a single structure. Upon binding an input strand to the sensor strand, the Cond-siRNA is activated and releases RNAi targeting a desired gene. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172461 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230611 | Naughton et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Brian Thomas Naughton (Mountain View, California); Colin Harvey (Mountain View, California); Ulrich Schlecht (Sunnyvale, California); Maureen Elizabeth Hillenmeyer (Palo Alto, California); Joe Horecka (Fremont, California) |
| ABSTRACT | Methods for identifying biosynthetic gene clusters that include genes for producing compounds that interact with specific target proteins are disclosed. Some methods relate to bioinformatics methods for identifying and/or prioritizing biosynthetic gene clusters. Related systems, components, and tools for the identification and expression of such gene clusters are also disclosed. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/158942 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/81 (20130101) Original (OR) Class C12N 15/1079 (20130101) C12N 15/1089 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230660 | RUVKUN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Gary B. RUVKUN (Malden, Massachusetts); Jothi Amaranath GOVINDAN (Malden, Massachusetts); Elamparithi JAYAMANI (Malden, Massachusetts) |
| ABSTRACT | Methods and compositions comprising carotenoids for the treatment or prevention of nausea, e.g., chemotherapy-induced nausea and vomiting. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228110 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/047 (20130101) A61K 35/66 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/01 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 23/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230667 | Bell et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Avery Davis Bell (Cambridge, Massachusetts); Steven A. McCarroll (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods for performing droplet-based high throughput sequencing upon genomic DNA of single cells (e.g., individual sperm). The instant disclosure provides a droplet that includes: i) a mammalian cell nucleus; and ii) a microbead presenting attached oligonucleotides, where the attached oligonucleotides include a nucleic acid sequence capable of hybridization and capture of genomic DNA and a microbead identification sequence that is common to all oligonucleotides attached to the microbead, where the mammalian cell nucleus is accessible to the microbead-attached oligonucleotides to an extent sufficient to allow for genomic DNA capture and amplification of genomic DNA to occur within the droplet. |
| FILED | Friday, April 26, 2019 |
| APPL NO | 17/053418 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230675 | Hung et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Deborah Hung (Cambridge, Massachusetts); Roby Bhattacharyya (Boston, Massachusetts); Jonathan Livny (Cambridge, Massachusetts); Peijun Ma (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions, methods, and kits for rapid phenotypic detection of antibiotic resistance/susceptibility. |
| FILED | Monday, August 26, 2019 |
| APPL NO | 17/271496 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/06 (20130101) C12N 1/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230678 | Pourmand et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nader Pourmand (San Mateo, California); Miloslav Karhanek (Santa Cruz, California); Ronald W. Davis (Stanford, California) |
| ABSTRACT | Methods and apparatus for direct detection of chemical reactions are provided. Electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The charge perturbation caused by the polymerase reaction can uniquely identify a DNA sequence. The polymerization process generates local perturbations of charge in the solution near the electrode surface and induces a charge in a polarazible gold electrode. This event is detected as a transient current by a voltage clamp amplifier. Detection of single nucleotides in a sequence can be determined by dispensing individual dNTPs to the electrode solution and detecting the charge perturbations. Alternatively, multiple bases can be determined at the same time using a mix of all dNTPs with subsequent analysis of the resulting signal. This technique may be adapted to other reaction determinations, such as enzymatic reactions, other electrode configurations, and other amplifying circuits. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/087336 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) B82Y 30/00 (20130101) B82Y 40/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3275 (20130101) G01N 27/3276 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230679 | Rao et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Anjana Rao (La Jolla, California); Mamta Tahiliani (New York, New York); Kian Peng Koh (Jamaica Plain, Massachusetts); Suneet Agarwal (Belmont, Massachusetts); Aravind Iyer (Bethesda, Maryland) |
| ABSTRACT | The present invention provides for methods of epigenetic analysis. In some cases, the methods may include obtaining a sample comprising a nucleic acid sequence. In some cases, the nucleic acid sequence may comprise one or more epigenetic marks. The methods may include performing a sequencing. The methods may include distinguishing a hydroxymethylated base from a methylated base. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208940 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2501/70 (20130101) C12N 2501/71 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/26 (20130101) C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 2521/531 (20130101) C12Q 2522/10 (20130101) C12Q 2537/164 (20130101) C12Q 2600/154 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230688 | Johnson-Buck |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Johnson-Buck (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein is technology relating to analyte detection and particularly, but not exclusively, to compositions, methods, systems, and kits for high-specificity detection of analytes using molecular probes that integrate cumulative repeated binding of probes to the same analyte molecule. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/160768 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6837 (20130101) C12Q 1/6874 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 21/6486 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230694 | Storch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Gregory Storch (St. Louis, Missouri); Jinsheng Yu (St. Louis, Missouri); Thomas J. Mariani (St. louis, Missouri) |
| ABSTRACT | The present disclosure provides molecular methods to improve the rapid diagnosis of respiratory infections. In general, the present disclosure provides method of detecting host gene signatures which aid in determining the etiology of a respiratory infection and thereby improve the treatment. |
| FILED | Wednesday, June 05, 2019 |
| APPL NO | 16/972440 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230697 | Kurian et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunil M. Kurian (San Diego, California); Michael M. Abecassis (Chicago, Illinois); John J. Friedewald (Chicago, Illinois) |
| ABSTRACT | This disclosure provides methods of detecting sub-acute rejection and other categories of rejection in kidney transplant recipients using unique sets of gene expression markers. |
| FILED | Friday, May 10, 2019 |
| APPL NO | 17/053834 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/142 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) G16B 50/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230699 | Giudice et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linda C. Giudice (Los Altos Hills, California); Juan C. Irwin (El Cerrito, California); John S. Tamaresis (Redwood City, California) |
| ABSTRACT | The present disclosure provides methods and compositions that are useful for diagnosing the presence or absence of endometriosis and the severity of endometriosis in a subject. The methods and compositions are also useful for distinguishing endometriosis from other uterine or pelvic pathologies in a subject. Also described are sets of genes whose expression levels in a biological sample are diagnostic for endometriosis, and compositions useful for diagnosis, prognosis, and/or treatment of endometriosis. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/153789 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230703 | CZERNIAK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Bogdan CZERNIAK (Houston, Texas); Keith BAGGERLY (Houston, Texas); Jolanta BONDARUK (Houston, Texas); Tadeusz MAJEWSKI (Houston, Texas); Colin DINNEY (Houston, Texas); Shizhen ZHANG (Houston, Texas); Yan WANG (Houston, Texas) |
| ABSTRACT | The present disclosure provides methods and compositions for the detection of bladder in a subject using four locus-specific probes to 6p22, 8q22, 11q13, and 20p11.2. |
| FILED | Wednesday, January 30, 2019 |
| APPL NO | 16/965409 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230704 | Song et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin Song (Baltimore, Maryland); Zhen Zhang (Dayton, Maryland); Daniel Wan-yui Chan (Clarksville, Maryland) |
| ABSTRACT | Provided herein are methods of detecting pancreatic cancer in a subject, the method comprising measuring in a sample from the subject a level of CA19-9 polysaccharide relative to a reference, and a level of a polynucleotide or polypeptide of at least one marker selected from the group consisting of: OPN, MIA, CEACAM-1, MIC-1, SPON1, HSP27, POSTN, and LGALS3BP relative to a reference, wherein an increased level of the CA19-9 polysaccharide relative to a reference and an increased level of the polynucleotide or polypeptide relative to a reference indicates presence of pancreatic cancer in the subject. |
| FILED | Tuesday, September 08, 2020 |
| APPL NO | 17/013989 |
| CURRENT CPC | Peptides C07K 14/4748 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231554 | Vacca et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kinetic River Corp. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giacomo Vacca (Campbell, California); Ralph Jimenez (Boulder, Colorado) |
| ABSTRACT | Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/209057 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) Original (OR) Class G01N 15/147 (20130101) G01N 15/1429 (20130101) G01N 15/1434 (20130101) G01N 2015/149 (20130101) G01N 2015/1006 (20130101) G01N 2015/1477 (20130101) G01N 2015/1488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231563 | ÜNLÜ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | M. Selim ÜNLÜ (Newton, Massachusetts); George G. Daaboul (Watertown, Massachusetts); Marcella Chiari (Milan, Italy) |
| ABSTRACT | Provided herein are methods for capturing extracellular vesicles from a biological sample for quantification and/or characterization (e.g., size and/or shape discrimination) using an SP-IRIS system. Also provided herein are methods of detecting a biomarker on captured extracellular vesicles or inside the captured vesicles (e.g., intra-vesicular or intra-exosomal biomarkers). |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/148855 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Original (OR) Class G01N 21/6458 (20130101) G01N 33/5432 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210231645 — METHODS AND COMPOSITIONS FOR INVESTIGATING MULTIPLE DRUG-DRUG TRANSPORTER INTERACTIONS
| US 20210231645 | LANGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert S. LANGER (Newton, Massachusetts); Carlo Giovanni TRAVERSO (Newton, Massachusetts); Yunhua SHI (Belmont, Massachusetts); Vance SOARES (Boston, Massachusetts); Daniel REKER (Durham, North Carolina) |
| ABSTRACT | Methods and compositions for determining multiplex interactions between drugs and drug transporters using an intestinal tissue explant are provided. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/118267 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) G01N 33/5088 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231650 | LINDSAY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arzona State University (SCOTTSDALE, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart LINDSAY (SCOTTSDALE, Arizona); Bintian ZHANG (SCOTTSDALE, Arizona) |
| ABSTRACT | The present disclosure relates to a sensing device and methods for detecting, and quantifying the amount of, a target protein in a sample. |
| FILED | Wednesday, May 08, 2019 |
| APPL NO | 17/053522 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5438 (20130101) Original (OR) Class G01N 33/6854 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231652 | LIOTTA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | George Mason Research Foundation, Inc. (Fairfax, Virginia) |
| ASSIGNEE(S) | George Mason Research Foundation, Inc. (Fairfax, Virginia) |
| INVENTOR(S) | Lance A. LIOTTA (Bethesda, Maryland); Alessandra Luchini KUNKEL (Burke, Virginia); Amanda N. Haymond STILL (Manassas, Virginia) |
| ABSTRACT | A labeling molecule is provided. The labeling molecule includes a compound of the following formula: CA-(M)-A]n. In the formula, “A” is a label anchor moiety, “M” is an identification moiety, and “CA” is a coordination agent moiety. The label anchor is an organic moiety that binds to a surface of a targeted biomolecule through noncovalent or covalent interactions at one end of the label anchor and binds a coordination moiety. The coordination moiety includes an identification moiety at an end that is distal to the end conjugated to the surface of the targeted biomolecule, and the subscript “n” is 1, 2, 3, 4, or 5. |
| FILED | Thursday, May 30, 2019 |
| APPL NO | 17/059081 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/2252 (20130101) G01N 33/54346 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231657 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Melody Smith (New York, New York); Marcel van den Brink (New York, New York); Eric Pamer (Montclair, New Jersey); Eric Littmann (Brooklyn, New York) |
| ABSTRACT | The present invention relates to compositions, methods, and kits for predicting a subject's response to a CAR T cell therapy, by analyzing the intestinal microbiome of the subject. The present disclosure also provides a method of detecting patients at risk for a poor response to CAR T cell therapy by measuring the level of the presently disclosed bacteria or bacterial genes in the microflora or microbiome of a patient receiving or considered for CAR T cell therapy. The present disclosure further provides therapeutic compositions and methods for treating a subject having a cancer, by improving the subject's response to a CAR T cell therapy. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/74 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) Original (OR) Class G01N 2496/00 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231666 | HEDRICK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Claire OLINGY (La Jolla, California); Huy DINH (La Jolla, California); LA JOLLA INSTITUTE FOR IMMUNOLOGY (La Jolla, California) |
| ASSIGNEE(S) | LA JOLLA INSTITUTE FOR IMMUNOLOGY (La Jolla, California) |
| INVENTOR(S) | Catherine HEDRICK (La Jolla, California); Claire OLINGY (La Jolla, California); Huy DINH (La Jolla, California) |
| ABSTRACT | Provided herein are methods of determining whether a subject will respond to a treatment for a neoplasia, neoplastic disorder, tumor, cancer or malignancy, the method comprising detecting the presence or amount of CDS 3 expressing cells in a biological sample from the subject, comparing the measured presence or amount to a reference presence or amount, wherein a modified measured presence or amount as compared to the reference presence or amount is indicative that the subject will or will not respond to the treatment for a neoplasia, neoplastic disorder, tumor, cancer or malignancy. Also described herein are methods of treating a neoplasia, neoplastic disorder, tumor, cancer or malignancy in a subject, the method comprising modulating CDS 3 activity or expression in a myeloid cell, or alternatively, comprising administering a population of CD33hi monocytes or CD33hi macrophages. |
| FILED | Thursday, June 06, 2019 |
| APPL NO | 15/734974 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) Original (OR) Class G01N 2333/70578 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231670 | Bitler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin G. Bitler (Denver, Colorado); Lindsay J. Wheeler (Denver, Colorado) |
| ABSTRACT | Disclosed herein are method and compounds useful in the analysis, diagnosis, and treatment of high grade serous ovarian carcinoma (HGSOC). Also disclosed are methods, compounds, and compositions useful in regulating Chromobox 2 (CBX2) expression and therapies for stem-ness, anoikis escape, HGSOC dissemination, and HGSCO chemoresistance. Applicants have identified CBX2 expression as being significantly elevated in HGSOC cells and tissues compared to benign counterparts. Also disclosed is elevated CBX2 expression in HGSOC cell lines, as well as elevated CBX2 expression in cells that are forced to grown in suspension. Reducing CBX2 results in inhibition of anchorage-independent proliferation and potentiation of anoikis-dependent apoptosis, as well as re-sensitization of HGSOC cells to platinum-based chemotherapy. |
| FILED | Friday, June 14, 2019 |
| APPL NO | 17/251645 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/243 (20190101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/531 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/57449 (20130101) Original (OR) Class G01N 2333/4704 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231672 | SHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaokun SHU (San Francisco, California); William Degrado (San Francisco, California); Tsz-Leung To (San Francisco, California); Hyunil Jo (San Francisco, California) |
| ABSTRACT | Provided herein are systems, methods and reagents for determining interactors (proteins or nucleic acids) that interact with a protein of interest. The subject system, methods and reagents advantageously allow for the identification of weak and transient protein-protein interactions. Such subject system, methods and reagents are useful, for example, for the determination of specific protein-interactor interactions that exist in particular diseases. Determination of these differences is useful, for example, in the drug development for the treatment of such diseases. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/227055 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/531 (20130101) G01N 33/582 (20130101) Original (OR) Class G01N 33/6803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231683 | Wandinger-Ness et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Angela Wandinger-Ness (Albuquerque, New Mexico); Tione Buranda (Albuquerque, New Mexico); Peter Simons (Albuquerque, New Mexico); Steve Young (Albuquerque, New Mexico) |
| ABSTRACT | The present invention is directed to the discovery that RapI-GTP, Racl-GTP and Flt3-L can be used as Biomarkers for the early detection of sepsis in patients suspected of a bacterial infection which presents as sepsis or is likely to produce sepsis. In particular, the present invention is directed to methods, assays and kits which may be used to distinguish sepsis (infection) from systematic inflammatory response caused by sterile inflammation in trauma patients. The method may he used to diagnose bacteria infection and/or sepsis and monitor therapy of a patient to allow modification of treatment and/or cessation of treatment. |
| FILED | Thursday, April 18, 2019 |
| APPL NO | 17/048941 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/563 (20130101) G01N 33/588 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/26 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231684 | Laurie |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gordon W. Laurie (Charlottesville, Virginia) |
| ABSTRACT | The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ˜90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ˜25 kDa syndecan-1 fragment is detectable in dry, but not normal tears. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/086188 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/18 (20130101) A61K 38/1709 (20130101) Peptides C07K 14/475 (20130101) Enzymes C12Y 302/01166 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/573 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/924 (20130101) G01N 2333/4706 (20130101) G01N 2333/4722 (20130101) G01N 2333/4728 (20130101) G01N 2333/70596 (20130101) G01N 2800/16 (20130101) G01N 2800/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231685 | Davies et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stella M. Davies (Cincinnati, Ohio); Nathan Luebbering (Cincinnati, Ohio) |
| ABSTRACT | The present invention relates to methods for improving the clinical management of hematopoietic stem cell transplant (HSCT) recipients by identifying patients at increased risk for non-relapse mortality or a transplantation associated adverse event using serum or plasma levels of vitamin D binding protein (VDBP) as a biomarker and related methods of monitoring therapy using same and the use of VDBP in therapy to prevent non-relapse mortality or a transplantation associated adverse event in a HSCT recipient, especially recipients identified as being at high risk. |
| FILED | Tuesday, May 07, 2019 |
| APPL NO | 17/250025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1722 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/82 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231691 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan D. Smith (Shaker Heights, Ohio); Stanley L. Hazen (Pepper Pike, Ohio); Shuhui Wang Lorkowski (Shaker Heights, Ohio) |
| ABSTRACT | Provided herein are compositions, systems, kits, and methods for performing an apoA1 exchange assay to determine the risk of MACE and/or for conducting an action based on the assay results. In some embodiments, methods are provided for generating, or receiving, a report that graphically displays: i) the subjects ApoA1 exchange rate in a sample as lower than a control or threshold value, and ii) the subjects risk of a major adverse cardiac event (MACE) and/or cardiovascular disease as being higher than normal. |
| FILED | Monday, June 03, 2019 |
| APPL NO | 15/734631 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 2333/775 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210233659 | CHENNUBHOTLA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | SRINIVAS C. CHENNUBHOTLA (PITTSBURGH, Pennsylvania); DOUGLASS L. TAYLOR (PITTSBURGH, Pennsylvania); SHIKHAR UTTAM FNU (PITTSBURGH, Pennsylvania) |
| ABSTRACT | A method of predicting cancer recurrence risk for an individual includes receiving patient spatial multi-parameter cellular and sub-cellular imaging data for a tumor of the individual, and analyzing the patient spatial multi-parameter cellular and sub-cellular imaging data using a prognostic model for predicting cancer recurrence risk to determine a predicted cancer recurrence risk for the individual, wherein the joint prognostic model is based on spatial correlation statistics among features derived for a plurality of intra-tumor spatial domains from spatial multi-parameter cellular and sub-cellular imaging data obtained from a plurality of cancer patients. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/056080 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/34 (20130101) G06K 9/4642 (20130101) G06K 9/6228 (20130101) G06K 9/6262 (20130101) G06K 2209/05 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210233753 | Krutchinsky et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Krutchinsky (New York, New York); Brian Chait (New York, New York) |
| ABSTRACT | A parallel multi-beam mass spectrometer includes an ion trap and a single multi-beam time-of-flight analyzer. The trap has a plurality of alternating electrodes configured to form a plurality of quadrupoles defining a surface of the trap, wherein at least two of the plurality of quadrupoles are configured as mass filters for selective ejection of concurrent parallel beams of ions from the trap in respective predetermined ion mass-to-charge windows. The single multi-beam time-of-flight analyzer has a position sensitive detector or a plurality of individual detectors for simultaneously receiving and analyzing the concurrent parallel beams of ions. |
| FILED | Wednesday, June 05, 2019 |
| APPL NO | 15/734808 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/009 (20130101) Original (OR) Class H01J 49/40 (20130101) H01J 49/4225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234570 | ELETREBY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rashad ELETREBY (Pittsburgh, Pennsylvania); Swarun KUMAR (Pittsburgh, Pennsylvania); Osman YAGAN (Pittsburgh, Pennsylvania); Diana ZHANG (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein is a system that overcomes challenges pertaining to density and range of urban LP-WANs despite the limited capabilities of base station and client hardware. The invention proposes a novel technique that aims to disentangle and decode large numbers of interfering transmissions at a simple, single-antenna LP-WAN base station by exploiting the hardware imperfections of low-cost LP-WAN clients to its advantage. Second, the present invention exploits the correlation of sensed data collected by LP-WAN nodes to collaboratively reach a far-away base station, even if individual clients are beyond its range. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/053406 |
| CURRENT CPC | Transmission H04B 1/69 (20130101) Original (OR) Class H04B 2001/6912 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0202 (20130101) H04L 27/103 (20130101) H04L 27/144 (20130101) H04L 27/265 (20130101) Wireless Communication Networks H04W 52/0209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210228426 | Darrah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Athena GTX, Inc. (Johnston, Iowa) |
| ASSIGNEE(S) | Athena GTX, Inc. (Johnston, Iowa) |
| INVENTOR(S) | Mark Darrah (Cumming, Iowa); Cesar Gradilla (Des Moines, Iowa); John Elson (San Antonio, Texas); Gregory T. Darrah (West Des Moines, Iowa); Allen E. Brandenburg (Dripping Springs, Texas) |
| ABSTRACT | Systems, devices, and methods for monitoring and treating a patient on route to a medical facility are disclosed. The system comprises a critical care unit; at least one patient monitoring device coupled to the critical care unit, wherein the critical care unit obtains physiological data about the patient from each patient monitoring device; at least one patient treatment device coupled to the critical care unit, wherein the critical care unit provides treatment instructions to each patient treatment device; a two way communications device coupled to the critical care unit; and a remote communications terminal in communication with the two way communications device. The critical care unit preferably sends the physiological data to the remote communications terminal and receives the treatment instructions from the remote communications terminal via the two way communications device. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/141654 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0002 (20130101) A61B 5/0022 (20130101) A61B 5/024 (20130101) A61B 5/6892 (20130101) Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 1/04 (20130101) A61G 1/06 (20130101) Original (OR) Class A61G 1/013 (20130101) A61G 2210/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229560 | Cavaroc et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America as Represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peyton B. Cavaroc (Hollywood, South Carolina); Jordan Chase McMahan (Ladson, South Carolina); Ray Austin Freeman (Ladson, South Carolina) |
| ABSTRACT | An unmanned aerial vehicle (UAV) for a remote oceanic environment includes a float system, at least one electric motor, and a seawater battery. The float system allows the UAV to maintain buoyancy on a body of water. The electric motor or motors produce the required lift for the UAV to achieve and maintain flight. The flight includes the UAV landing on the body of water and takeoff from the body of water. The seawater battery directly or indirectly powers the electric motor or motors using seawater from the body of water while the UAV is floating on the body of water. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/121120 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 8/003 (20130101) B60L 50/60 (20190201) B60L 53/00 (20190201) Original (OR) Class B60L 53/51 (20190201) B60L 2200/10 (20130101) Aeroplanes; Helicopters B64C 35/001 (20130101) B64C 35/006 (20130101) B64C 39/024 (20130101) B64C 2201/027 (20130101) B64C 2201/042 (20130101) B64C 2201/108 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 6/34 (20130101) H01M 10/465 (20130101) H01M 2220/20 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229798 | CHRISTENSEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bell Textron Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Bell Textron Inc. (Fort Worth, Texas) |
| INVENTOR(S) | Kevin Thomas CHRISTENSEN (Plano, Texas); Hunter Barton NELSON (North Richland Hills, Texas); Martin Wesley SHUBERT (Tall Timbers, Maryland); Paul David RUCKEL (Fort Worth, Texas) |
| ABSTRACT | An exemplary method for controlling low speed flight of an aircraft having a controller receiving pilot input includes transitioning from a translational rate command (TRC) to a linear acceleration command (LAC) when the controller is displaced above a control transition displacement (CTD), and while in LAC holding speed when the controller is relaxed to CTD. |
| FILED | Wednesday, January 29, 2020 |
| APPL NO | 16/775531 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 15/12 (20130101) B64C 19/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229827 | Doman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | David B. Doman (Springfield, Ohio) |
| ABSTRACT | A thermal management system for an aircraft and method of using same are provided. The system includes a fuel reservoir, a fuel recirculation loop, a fuel mixing valve, and a control module. The fuel recirculation loop includes a fuel recirculation tank, heat exchanger that transfers waste thermal energy to the fuel, and another heat exchanger that transfers waste thermal energy out of the heated fuel. The fuel recirculation loop supplies heated fuel to a combustion engine and is configured to return a portion of the heated fuel to the recirculation tank via a return line. The fuel mixing valve fluidly couples the fuel reservoir and the fuel recirculation tank to provide a mixture of the two fuel sources based on the temperature of the heated fuel. The thermal management system increases an aircraft thermal endurance over that which can be attained by a single tank fuel flow topology. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/110448 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 37/34 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229947 | Bultman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Alan Bultman (San Diego, California); Rudy Padilla (San Diego, California) |
| ABSTRACT | A system and method for non-contact measurement of remaining spooled material. The system comprises at least one optical signal source configured to illuminate spooled material with an optical beam having an optical beam width that illuminates the material remaining in the spool. The optical beam width and spacing are such that spooled material is illuminated by each optical signal source. The system includes drive circuitry configured to drive the at least one optical signal source using pulses. The system further includes at least one optical signal receiver configured to receive light reflected from each of said light pulses. The system still further includes a processor configured to: establish a number and drive strength of the pulses; and cause measurements to be performed of the remaining spooled material. |
| FILED | Monday, January 27, 2020 |
| APPL NO | 16/773753 |
| CURRENT CPC | Handling Thin or Filamentary Material, e.g Sheets, Webs, Cables B65H 61/00 (20130101) Original (OR) Class B65H 2511/112 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/00 (20130101) Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 17/00 (20130101) Image Data Processing or Generation, in General G06T 7/62 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229987 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chi Hwan Lee (West Lafayette, Indiana); Zahyun Ku (Beavercreek, Ohio); Augustine Michael Urbas (Oakwood, Ohio); Bongjoong Kim (West Lafayette, Indiana) |
| ABSTRACT | Nanoassembly methods for producing quasi-3D plasmonic films with periodic nanoarrays of nano-sized surface features. A sacrificial layer is deposited on a surface of a donor substrate having periodic nanoarrays of nanopattern features formed thereon. A plasmon film is deposited onto the sacrificial layer and a dielectric spacer is deposited on the plasmon film. The donor substrate having the sacrificial layer, plasmon film, and dielectric spacer thereon is immersed in a bath of etchant to selectively remove the sacrificial layer such that the plasmon film and the dielectric spacer thereon adhere to the surface of the donor substrate. The dielectric spacer and the plasmon film are mechanically separated from the donor substrate to define a quasi-three dimensional (3D) plasmonic film having periodic nanoarrays of nano-sized surface features defined by the nanopattern features of the donor substrate surface. The quasi-3D plasmonic film is then applied to a receiver substrate. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/126316 |
| CURRENT CPC | Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 3/0014 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230040 | Nguyen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinh Q. Nguyen (Fairfax, Virginia); Jasbinder S. Sanghera (Ashburn, Virginia); Daniel J. Gibson (Falls Church, Virginia); Mikhail Kotov (Silver Spring, Maryland); Gryphon A. Drake (Potomac, Maryland); Shyam S. Bayya (Ashburn, Virginia) |
| ABSTRACT | A high optical quality multicomponent chalcogenide glasses without refractive index perturbations due to striae, phase separation or crystal formation made using a sealed ampoule with chemical components enclosed inside, a two-zone furnace, a convection heating/mixing step, and multiple fining steps. Initially, the sealed ampoule is oriented vertically within the two-zone furnace and heated to melt the chemical components contained within, and a temperature gradient is created between the top zone and the bottom zone such that the bottom zone has a higher temperature. This temperature gradient causes convection currents within the viscous liquid until it is sufficiently mixed due to the convective flow. Then the temperature gradient is reversed such that the top zone now has a higher temperature and the convective flow ceases. The furnace temperatures are then reduced over a period of time, with holds at multiple temperatures for fining and cooling to form a solid glass. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228313 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 17/00 (20130101) Manufacture, Shaping, or Supplementary Processes C03B 5/06 (20130101) C03B 5/235 (20130101) Original (OR) Class C03B 2201/86 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 1/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230072 | Dickerson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew B. Dickerson (Beavercreek, Ohio); Kara L. Martin (Beavercreek, Ohio) |
| ABSTRACT | The present invention relates to preceramic polymer grafted nanoparticles and as well as methods of making and using same. Advantages of such preceramic polymer grafted nanoparticles include, reduced out gassing, desired morphology control and desirable, distinct rheological properties that are not found in simple mixtures. As a result, Applicants' preceramic polymer grafted nanoparticles can be used to provide significantly improved, items including but not limited to hypersonic vehicles, jets, rockets, mirrors, signal apertures, furnaces, glow plugs, brakes, and armor. |
| FILED | Tuesday, December 08, 2020 |
| APPL NO | 17/114628 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/571 (20130101) C04B 35/589 (20130101) Original (OR) Class C04B 35/626 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230118 | Gorodetsky et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Alon Gorodetsky (Irvine, California); David Joshua Dibble (Santa Ana, California); Mehran Umerani (Irvine, California); Amir Mazaheripour (Irvine, California); Young Suk Park (Huntington Beach, California); Anthony Burke (Fountain Valley, California) |
| ABSTRACT | Quinolines, polyquinolines, polybenzoquinolines, molecular segments of fullerenes and graphene nanoribbons, and graphene nanoribbons and processes for producing such materials are provided. The processes utilize a form of an aza-Diels-Alder (Povarov) reaction to first form quinolines and/or polyquinolines. In some such embodiments polyquinolines thus produced are used to form graphene nanoribbon precursors, and molecular segments and graphene nanoribbons. In many such embodiments the graphene nanoribbone precursors are formed from polybenzoquinolines. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/156403 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/152 (20170801) Acyclic or Carbocyclic Compounds C07C 5/02 (20130101) Heterocyclic Compounds C07D 215/04 (20130101) C07D 215/06 (20130101) Original (OR) Class C07D 215/12 (20130101) C07D 215/18 (20130101) C07D 221/06 (20130101) C07D 221/12 (20130101) C07D 401/14 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/7862 (20130101) C08G 73/0688 (20130101) Compositions of Macromolecular Compounds C08L 79/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230191 | Mirica et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Katherine A. Mirica (Hanover, New Hampshire); Lukasz K. Mendecki (White River Junction, Vermont); Michael KO (West Lebanon, New Hampshire) |
| ABSTRACT | In some embodiments, the present disclosure pertains to a method of forming metalorganic frameworks. In some embodiments, the method includes exposing a plurality of zerooxidation state metal atoms to an oxidizing agent. In some embodiments, the exposing facilitates oxidation of the plurality of zero-oxidation state metal atoms to a plurality of metallic ions. In some embodiments, the plurality of metallic ions react with a plurality of ligands to form the metal-organic frameworks. In some embodiments, the formed metal-organic frameworks comprise one or more metals and one or more ligands coordinated with the one or more metals. |
| FILED | Thursday, June 06, 2019 |
| APPL NO | 15/734789 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) Original (OR) Class C07F 15/045 (20130101) C07F 15/065 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/18 (20130101) C23C 14/26 (20130101) C23C 14/5846 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230230 | Broder et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland) |
| ASSIGNEE(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland) |
| INVENTOR(S) | Christopher C. Broder (Silver Spring, Maryland); Katharine N. Bossart (San Francisco, California) |
| ABSTRACT | This invention relates to soluble forms of G glycoprotein from Hendra and Nipah virus. In particular, this invention relates to compositions comprising soluble forms of G glycoprotein from Hendra and Nipah virus and also to diagnostic and therapeutic methods using the soluble forms of G glycoprotein from Hendra and Nipah virus. Further, the invention relates to therapeutic antibodies including neutralizing antibodies, and vaccines for the prevention and treatment of infection by Hendra and Nipah viruses. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/161720 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00 (20130101) A61K 39/12 (20130101) A61K 39/155 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/07 (20130101) C07K 14/115 (20130101) C07K 16/1027 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230586 | Jewett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Joongoo Lee (Evanston, Illinois); Jeffrey S. Moore (Savoy, Illinois); Kenneth E. Schwieter (Champaign, Illinois); Kevin Jerome Schwarz (Champaign, Illinois) |
| ABSTRACT | Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer. |
| FILED | Monday, June 03, 2019 |
| APPL NO | 15/734182 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230601 | YAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao YAN (Chandler, Arizona); Fei ZHANG (Chandler, Arizona); Xiaodong QI (Tempe, Arizona) |
| ABSTRACT | In some embodiments, complex molecular knots with high crossing numbers are achieved by folding, following a prescribed folding order, single-stranded DNA or RNA of customized sequences into target shapes. Such complex molecular knots with high crossing numbers are useful for biomedical applications including use as immunostimulatory agents and/or protein hosts and carriers. |
| FILED | Thursday, April 25, 2019 |
| APPL NO | 17/050918 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) Original (OR) Class C12N 2310/17 (20130101) C12N 2310/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230661 | Petillo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Design-Zyme LLC (Lawrence, Kansas) |
| ASSIGNEE(S) | Design-Zyme LLC (Lawrence, Kansas) |
| INVENTOR(S) | Peter Albert Petillo (Lawrence, Kansas); Dwight O'Dell Deay, III (Lawrence, Kansas); Michael Gregory Branden (Lawrence, Kansas) |
| ABSTRACT | The present invention is broadly concerned with new in vitro glycosylation methods that provide rational approaches for producing glycosylated proteins, and the use of glycosylated proteins. In more detail, the present invention comprises methods of glycosylating a starting protein having an amino sidechain with a nucleophilic moiety, comprising the step of reacting the protein with a carbohydrate having an oxazoline moiety on the reducing end thereof, to covalently bond the amino sidechain of the starting protein with the oxazoline moiety, wherein the glycosylated protein substantially retains the structure and function of the starting protein. Target proteins include oxidase, oxidoreductase and dehydrogenase enzymes. The glycosylated proteins advantageously have molecular weights of at least about 7500 Daltons. In a further embodiment, the present invention concerns the use of glycosylated proteins, fabricated by the methods disclosed herein, in the assembly of amperometric biosensors. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/301590 |
| CURRENT CPC | Peptides C07K 1/006 (20130101) C07K 1/1077 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0004 (20130101) C12N 9/0006 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231198 | Emmons |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HAMILTON SUNDSTRAND CORPORATION (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Floyd Richard Emmons (West Hartford, Connecticut) |
| ABSTRACT | A linear actuator includes a planetary gear system includes a sun gear, a ring gear, and a planet carrier. A linear output mechanism is coupled to the planetary gear system. A first motor is configured to drive a first input shaft, and the first input shaft is coupled to the planet carrier. A second motor is configured to drive a second input shaft, and the second input shaft is coupled to the ring gear. A first brake is coupled to the first motor and is configured to be engaged into a braked position that holds the planet carrier fixed. In the braked position, rotation of the ring gear results in rotation of the sun gear for linear displacement of the linear output mechanism. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/153025 |
| CURRENT CPC | Gearing F16H 25/205 (20130101) Original (OR) Class F16H 2025/2081 (20130101) F16H 2025/2087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231234 | Di Carlo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Di Carlo (Long Beach, California); Brian T. Vaniman (Fountain Valley, California); John P. Leuer (Newport Beach, California) |
| ABSTRACT | A conduit (100) for transporting a fluid comprises a first collar (102), a second collar (103), and a bellows (108). The bellows (108) comprises a first corrugated outboard ply (114), a corrugated inboard ply (110), an interstitial space (126), interposed between the corrugated inboard ply (110) and the first corrugated outboard ply (114), and a second corrugated outboard ply (112) within the interstitial space (126). The first corrugated outboard ply (114) and the corrugated inboard ply (110) are hermetically coupled to the first collar (102) and the second collar (103). The conduit (100) additionally comprises a first sensor 116, communicatively coupled with an interstitial space (126). The second corrugated outboard ply (112) is not hermetically coupled to the first collar (102) or the second collar (103). |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/143073 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 5/022 (20130101) Original (OR) Class F16L 27/111 (20130101) F16L 2201/30 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231235 | Di Carlo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Di Carlo (Long Beach, California); Brian T. Vaniman (Fountain Valley, California); John P. Leuer (Newport Beach, California) |
| ABSTRACT | A conduit (100) for transporting a fluid comprises a first collar (102), a second collar (103), and a bellows (108). The bellows (108) comprises a corrugated inboard ply (110), a corrugated outboard ply (112), and an interstitial space (126), interposed between the corrugated inboard ply (110) and the corrugated outboard ply (112). The conduit additionally comprises a first weld (138), hermetically coupling the corrugated inboard ply (110) and a first outer collar portion (104), a second weld (134), hermetically coupling the corrugated outboard ply (112) and a first inner collar portion (106), a third weld (186), hermetically coupling the corrugated inboard ply (110) and a second outer collar portion (105), a fourth weld (184), hermetically coupling the corrugated outboard ply (112) and a second inner collar portion (107), and a first sensor (116), communicatively coupled with the interstitial space (126). |
| FILED | Thursday, January 07, 2021 |
| APPL NO | 17/143888 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 5/022 (20130101) Original (OR) Class F16L 27/111 (20130101) F16L 2201/30 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231425 | Zemany et al. |
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| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Paul Zemany (Amherst, New Hampshire); Matthew Chrobak (Groton, Massachusetts); Egor V. Degtiarev (Merrimack, New Hampshire) |
| ABSTRACT | A guided projectile including a precision guidance munition assembly utilizes at least one maneuver envelope to optimally control movement of at least one canard to steer the guided projectile during flight. The maneuver envelopes optimize movements of the at least one canard that effectuate movement in either the range direction or the cross-range direction, or both. The maneuver envelope enables optimal timing such that maneuvering in one direction does not come at the expense of maneuver authority in the other direction. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/263960 |
| CURRENT CPC | Weapon Sights; Aiming F41G 7/008 (20130101) F41G 7/346 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 15/01 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231612 | Dogaru et al. |
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| FUNDED BY |
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| APPLICANT(S) | Southwest Research Institute (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Teodor Dogaru (San Antonio, Texas); Clinton J. Thwing (Bulverde, Texas); Darryl Wagar (San Antonio, Texas) |
| ABSTRACT | A method of testing the residual stress around a cold-worked hole in a test material. The test uses two identical eddy current coil pairs, each pair having a driving coil and a pickup coil. One coil pair is placed into the cold-worked hole. The other coil pair is placed into a non-cold worked hole in a reference material. When the coils are activated, and with a properly chosen phase difference between the excitation signal and the output signal, the in-phase component of the output voltage signal can be correlated to residual stress around the cold-worked hole. |
| FILED | Tuesday, January 28, 2020 |
| APPL NO | 16/774119 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 7/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/904 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231633 | Lock et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evgeniya H. Lock (Annandale, Virginia); F. Keith Perkins (Alexandria, Virginia); Anthony K. Boyd (Arlington, Virginia); Rachael L. Myers-Ward (Springfield, Virginia); David Kurt Gaskill (Alexandria, Virginia); Anindya Nath (Fairfax, Virginia) |
| ABSTRACT | A sensitive and selective, in-line method to measure and validate the sulfur content at ppb levels in both the liquid and gas phase of an analyte. The method includes patterning graphene, for example to form a mesa structure comprising horizontal or vertical lines or an array of multidentate star features; functionalizing the patterned graphene and attaching nanoparticles to the functionalized graphene to form a device; exposing the device to an analyte in the gas or liquid phase; detecting a change in electrical response when sulfur is present in the analyte; and recovering the device for future use. Also disclosed is the related sulfur detector. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228247 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/127 (20130101) G01N 33/00 (20130101) G01N 33/22 (20130101) G01N 33/0044 (20130101) G01N 33/287 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231677 | Mrksich et al. |
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| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milan Mrksich (Hinsdale, Illinois); Kazi Y. Helal (Evanston, Illinois) |
| ABSTRACT | The present disclosure is directed to materials and methods of high throughput, traceless immobilization of analytes for use in self-assembled monolayer for matrix-assisted laser desorption and ionization (SAMDI) mass spectrometry. Methods of the disclosure are useful, in various embodiments, for measuring the activity of an enzyme or for monitoring a chemical reaction. |
| FILED | Friday, June 07, 2019 |
| APPL NO | 16/972386 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2610/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231683 | Wandinger-Ness et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Angela Wandinger-Ness (Albuquerque, New Mexico); Tione Buranda (Albuquerque, New Mexico); Peter Simons (Albuquerque, New Mexico); Steve Young (Albuquerque, New Mexico) |
| ABSTRACT | The present invention is directed to the discovery that RapI-GTP, Racl-GTP and Flt3-L can be used as Biomarkers for the early detection of sepsis in patients suspected of a bacterial infection which presents as sepsis or is likely to produce sepsis. In particular, the present invention is directed to methods, assays and kits which may be used to distinguish sepsis (infection) from systematic inflammatory response caused by sterile inflammation in trauma patients. The method may he used to diagnose bacteria infection and/or sepsis and monitor therapy of a patient to allow modification of treatment and/or cessation of treatment. |
| FILED | Thursday, April 18, 2019 |
| APPL NO | 17/048941 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/563 (20130101) G01N 33/588 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/26 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231813 | Camparo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Camparo (Redondo Beach, California); Travis Driskell (Santa Monica, California) |
| ABSTRACT | Time-synchronization of a space-system having a plurality of satellites is described herein. During a first period, a first satellite of the plurality of satellites is designated as a master satellite. A clock of the master satellite is configured to provide time and frequency to remaining satellites of the plurality of satellites and the remaining satellites are designated as slave satellites. During a second period, a second satellite of the slave satellites is designated as the master satellite based on a performance indictor and the first satellite is designated as a slave satellite. During the first period and the second period, clocks of the slave satellites are cross-linked with a clock of the master satellite using time transfer. At least one satellite during the first period and the second period, delivers time data having the time and the frequency generated by a clock of the at least one satellite. |
| FILED | Thursday, January 23, 2020 |
| APPL NO | 16/751028 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/02 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231913 | Guzman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Andrew Guzman (Wakefield, Massachusetts); Joseph Flaherty (Boston, Massachusetts); Steven R. Gillmer (Somerville, Massachusetts); Kevin Edward Sullivan (Medford, Massachusetts); Steven Augst (Acton, Massachusetts) |
| ABSTRACT | A ruggedized adjustable mounting system is described for adjustably coupling and selectively locking a component supported in a fixture of the mount in a desired orientation. In some embodiments, the mounting system includes one or more kinematic couplings that support a fixture on a base and one or more adjustable couplings that are configured to adjust a separation distance between two opposing portions of the fixture and the base to selectively pivot the fixture about one or more axes of rotation. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 16/953001 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 7/1825 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232045 | Shi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Phase Sensitive Innovations, Inc. (Newark, Delaware) |
| ASSIGNEE(S) | Phase Sensitive Innovations, Inc. (Newark, Delaware) |
| INVENTOR(S) | Shouyuan Shi (Newark, Delaware); Dennis Prather (Newark, Delaware); Peng Yao (Newark, Delaware); Janusz MURAKOWSKI (Bear, Delaware) |
| ABSTRACT | This disclosure is directed to two-dimensional conformal optically-fed phased arrays and methods for manufacturing the same. The method includes providing a wafer substrate, depositing a first cladding layer on the wafer substrate, and depositing a core layer on the first cladding layer. The method further includes photolithographically patterning the core layer to provide a plurality of optical waveguide cores, and depositing a second cladding layer on the core layer to cover the plurality of optical waveguide cores to provide a plurality of optical waveguides. In addition, the method includes forming a plurality of antennas on the second cladding layer, each antenna of the plurality of antennas located near a termination of a corresponding optical waveguide of the plurality of optical waveguides, and providing a plurality of photodiodes on the second cladding layer, each photodiode of the plurality of photodiodes connected to a corresponding antenna. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/159628 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0005 (20130101) Original (OR) Class G03F 7/16 (20130101) Antennas, i.e Radio Aerials H01Q 1/38 (20130101) H01Q 3/2676 (20130101) H01Q 21/062 (20130101) H01Q 21/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232091 | Hong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiarong Hong (New Brighton, Minnesota); Siyao Shao (Minneapolis, Minnesota); Kevin Mallery (St Paul, Minnesota) |
| ABSTRACT | A method comprises obtaining input data comprising a hologram of a 3-dimensional (3D) particle field, a depth map of the 3D particle field, and a maximum phase projection of the 3D particle field. The method also comprises applying a U-net convolutional neural network (CNN) to the input data to generate output data. Encoder blocks have residual connections between a first layer and a second layer that skips over a convolution layer of the encoder block. Decoder blocks have residual connections between a first layer and a second layer that skips over a convolution layer of the decoder block. The output data includes a channel in which pixel intensity corresponds to relative depth of particles in the 3D particle field and an output image indicating locations of centroids of the particles in the 3D particle field. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/248584 |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/0443 (20130101) Original (OR) Class G03H 2210/30 (20130101) G03H 2210/55 (20130101) G03H 2210/56 (20130101) Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/50 (20170101) G06T 7/60 (20130101) G06T 7/70 (20170101) G06T 2207/10028 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232379 | Baskaran et al. |
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| FUNDED BY |
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| APPLICANT(S) | Reservoir Labs, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Muthu Manikandan Baskaran (Old Tappan, New Jersey); Benoit J. Meister (New York, New York); Benoit Pradelle (Brooklyn, New York) |
| ABSTRACT | A system for compiling programs for execution thereof using a hierarchical processing system having two or more levels of memory hierarchy can perform memory-level-specific optimizations, without exceeding a specified maximum compilation time. To this end, the compiler system employs a polyhedral model and limits the dimensions of a polyhedral program representation that is processed by the compiler at each level using a focalization operator that temporarily reduces one or more dimensions of the polyhedral representation. Semantic correctness is provided via a defocalization operator that can restore all polyhedral dimensions that had been temporarily removed. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/034895 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/41 (20130101) G06F 8/452 (20130101) G06F 8/4436 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232511 | BOETTCHER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arm Limited (Cambridge, Cambridgeshire, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias Lothar BOETTCHER (Cambridge, Cambridgeshire, United Kingdom); François Christopher Jacques BOTMAN (Cambridge, Cambridgeshire, United Kingdom) |
| ABSTRACT | An apparatus comprises capability checking circuitry 86 to perform a capability validity checking operation to determine whether use of a capability satisfies one or more use-limiting conditions. The capability comprises a pointer and pointer-use-limiting information specifying the one or more use-limiting conditions. The one or more use-limiting conditions comprise at least an allowable range of addresses for the pointer. In response to a capability write request requesting that a capability is written to a memory location associated with a capability write target address, when capability write address tracking is enabled, capability write address tracking circuitry 200 updates a capability write address tracking structure 100 based on the capability write target address. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 16/975255 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0238 (20130101) G06F 12/1009 (20130101) G06F 12/1441 (20130101) Original (OR) Class G06F 2212/1052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232729 | Stacy et al. |
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| FUNDED BY |
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| APPLICANT(S) | Aptima, Inc. (Woburn, Massachusetts) |
| ASSIGNEE(S) | Aptima, Inc. (Woburn, Massachusetts) |
| INVENTOR(S) | E. Webb Stacy (Andover, Massachusetts); John Colonna-Romano (Stow, Massachusetts) |
| ABSTRACT | Systems and methods to define a scenario of conditions comprising the steps of defining at least one condition for at least one educational objective, the at least one condition being represented by a constraint and scheduling the conditions into a scenario of conditions. In some embodiments, the scheduling is performed by analyzing the constraints using constraint programming. In some embodiments, the constraints comprise mathematical or computational constraints representing a range of variables. Also disclosed are systems and methods to monitor a scenario of conditions. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/132888 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class G06F 2111/04 (20200101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232772 | Scott |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Alicia L Scott (Bloomington, Indiana) |
| ABSTRACT | The present invention relates to a system that uses natural language processing (NLP) to read data from a file and analyze the data based on user defined parameters. According to an illustrative embodiment of the present disclosure, a system can process and analyze a data file by finding trending themes across data entries. According to a further illustrative embodiment of the present disclosure, the system can search for reoccurring words/phrases based on Ngrams (i.e. n-grams). The system can be adapted to search for Ngrams of varying length depending on the information sought and can sort the results by Ngram length. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157122 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/30 (20200101) Original (OR) Class G06F 40/226 (20200101) G06F 40/284 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232902 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Spero Devices, Inc. (Acton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jai Gupta (Westford, Massachusetts); Nihar Athreyas (Marlborough, Massachusetts); Abbie Mathew (Westford, Massachusetts); Marc Edouard Gauthier (Verdun, Canada) |
| ABSTRACT | A high-endurance, computation-in-memory processor includes a plurality of memory computation modules (MCMs). Each of the MCMs comprise a plurality of memory arrays and a respective module controller to program the plurality of memory arrays to perform mathematical operations on a data set, as well as communicate with other of the MCMs to control a data flow between the MCMs. An inter-module interconnect transports operational data between the MCMs, and communicates with the MCMs to maintain queues storing the operational data during transport between the MCMs. A digital signal processor (DSP) transmits input data to the MCMs and retrieves processed data output by the MCMs. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/156172 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0604 (20130101) G06F 3/0656 (20130101) G06F 3/0688 (20130101) G06F 9/545 (20130101) G06F 9/3005 (20130101) G06F 9/30036 (20130101) Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232961 | Higa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center, Pacific (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by Secretary of the Navy (San Diego, California) |
| INVENTOR(S) | Brian A. Higa (San Diego, California); Kenneth S. Simonsen (San Diego, California); Osama M. Nayfeh (San Diego, California) |
| ABSTRACT | A method useful for network and spectrum defense which operates to analyze cyber data and spectra while performing real time optimization which is based on the analyzed cyber data or spectrum. The method utilizes quantum computing and reconfigurable qubits with built-in memory to sample a target cyber data or spectrum, search through the sample and determine a desired or required network or spectrum reallocation, and determine optimal values for its order parameters and Hamiltonian and tune the qubits in accordance with the determination. An embodiment may provide for spectrum optimization that minimizes frequency bandwidth, power, and bit error rate. The desired or required network or spectrum reallocation and optimal values order parameters and Hamiltonian may be stored in the built-in memory to facilitate machine learning. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 16/751339 |
| CURRENT CPC | Electric Digital Data Processing G06F 15/7867 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232962 | Wei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Xuan Wei (White Plains, New York); Sarah Elizabeth Sheldon (Tarrytown, New York); Maika Takita (Hudson, New York); Jay Michael Gambetta (Yorktown Heights, New York) |
| ABSTRACT | An embodiment includes (CR) gate having a first control qubit coupled with a first target qubit, and a second CR gate having a second control qubit coupled with a second target qubit and the first control qubit. The embodiment also includes controller circuitry for performing operations including first and second iterations of: during a first time period, directing respective CR pulses to the first and second control qubits; during a second time period, directing respective single qubit pulses to the first control qubit and to the second target qubit; during a third time period, directing respective CR pulses to the first and second control qubits; and during a fourth time period, directing respective single qubit pulses to the second control qubit and to the first target qubit. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/128661 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210233316 | Manser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Army (Fort Belvoir, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kimberly E. Manser (Alexandria, Virginia); Sina Simingalam (Mclean, Virginia); Joseph P. Reynolds (Haymarket, Virginia); Jason A. Willis (Dumfries, Virginia); Van A. Hodgkin (Stafford, Virginia); Roger W. Thompson, JR. (Springfield, Virginia) |
| ABSTRACT | A method for generating an augmented set of images involves data collection, data processing, and data augmentation processing performed to merge images. The data collection comprises the steps of choosing objects as selected objects, choosing configurations for imaging of the selected objects, and taking pictures with a second camera to create a set of raw object images. The data processing comprises the steps of performing dynamic range adjustment on the raw object image, performing color correction for corrected images, and removing uniform background from the corrected images to result in object images. The data augmentation processing performed to merge images comprises the steps of performing range simulation or magnification for resampled images, adding blur to the resampled images, adding noise to create final object images, and merging the final object images to the field images of a first camera to create a set of augmented images. |
| FILED | Friday, November 27, 2020 |
| APPL NO | 17/105700 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/003 (20130101) G06T 5/009 (20130101) G06T 5/50 (20130101) G06T 19/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210233508 | McLoughlin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zeteo Tech, Inc. (Sykesville, Maryland) |
| ASSIGNEE(S) | Zeteo Tech, Inc. (Sykesville, Maryland) |
| INVENTOR(S) | Michael McLoughlin (Sykesville, Maryland) |
| ABSTRACT | Systems and methods for enhanced hearing protection and data recording are disclosed. Recorded data is analyzed to determine user compliance with standard operating procedures. Additionally, hearing loss is monitored using neurological response of the auditory system to environmental noise. Optional sensors such as temperature sensors, accelerometers, GPS sensors are used to correlate noise data with external events. An optional acoustic source may be used to identify unusual conditions such as ear drum perforations and capture information related to health of the tympanic membrane and external auditory meatus. The systems and methods may also be used to protect the hearing and utility of military working dogs. |
| FILED | Monday, June 03, 2019 |
| APPL NO | 15/734964 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/002 (20130101) A61B 5/0022 (20130101) A61B 5/126 (20130101) A61B 5/388 (20210101) A61B 5/1112 (20130101) A61B 5/6817 (20130101) A61B 5/14551 (20130101) A61B 2562/0219 (20130101) A61B 2562/0271 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 11/08 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/17815 (20180101) Original (OR) Class G10K 11/17861 (20180101) G10K 11/17881 (20180101) G10K 2210/1081 (20130101) G10K 2210/3026 (20130101) G10K 2210/3027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210233857 | HERRAULT |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Florian G. HERRAULT (Malibu, California) |
| ABSTRACT | An electronic assembly comprising a carrier wafer having a top wafer surface and a bottom wafer surface; an electronic integrated circuit being formed in the carrier wafer and comprising an integrated circuit contact pad on the top wafer surface; said carrier wafer comprising a through-wafer cavity having walls that join said top wafer surface to said bottom wafer surface; a component chip having a component chip top surface, a component chip bottom surface and component chip side surfaces, the component chip being held in said through-wafer cavity by direct contact of at least a side surface of said component chip with an attachment metal that fills at least a portion of said through-wafer cavity; said component chip comprising at least one component contact pad on said component chip bottom surface; and a conductor connecting said integrated circuit contact pad and said component contact pad. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/214374 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/5386 (20130101) Original (OR) Class H01L 24/40 (20130101) H01L 24/48 (20130101) H01L 25/50 (20130101) H01L 25/0655 (20130101) H01L 2224/40157 (20130101) H01L 2224/48157 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234001 | Chabak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelson D. Chabak (Springboro, Ohio); Andrew J. Green (Beavercreek, Ohio); Gregg H. Jessen (Beavercreek, Ohio) |
| ABSTRACT | Methods of forming a self-aligned gate (SAG) and self-aligned source (SAD) device for high Ecrit semiconductors are presented. A dielectric layer is deposited on a high Ecrit substrate. The dielectric layer is etched to form a drift region. A refractory material is deposited on the substrate and dielectric layer. The refractory material is etched to form a gate length. Implant ionization is applied to form high-conductivity and high-critical field strength source with SAG and SAD features. The device is annealed to activate the contact regions. Alternately, a refractory material may be deposited on a high Ecrit substrate. The refractory material is etched to form a channel region. Implant ionization is applied to form high-conductivity and high Ecrit source and drain contact regions with SAG and SAD features. The refractory material is selectively removed to form the gate length and drift regions. The device is annealed to activate the contact regions. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/210635 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/0856 (20130101) H01L 29/0873 (20130101) Original (OR) Class H01L 29/41775 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234277 | Zekios et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Constantinos L. Zekios (Miami, Florida); Stavros Georgakopoulos (Miami, Florida); Muhammad Hamza (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Constantinos L. Zekios (Miami, Florida); Stavros Georgakopoulos (Miami, Florida); Muhammad Hamza (Miami, Florida) |
| ABSTRACT | Antenna devices are provided, including tightly coupled arrays, transmitarrays, and reflectarrays. An antenna device can include a plurality of substrates each having an antenna element. The substrates can be provided in connected series or in an array. The substrates can be part of an origami array such that the entire array is foldable. The substrates can optionally be attached to a framework that can actuate the substrates to different configurations. By bending, folding, or otherwise repositioning the substrates/array, the electromagnetic characteristics of the antenna device can be easily reconfigured for the desired task. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213645 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/08 (20130101) H01Q 1/38 (20130101) H01Q 9/285 (20130101) H01Q 9/0414 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234528 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yansong Yang (Urbana, Illinois); Ruochen Lu (Champaign, Illinois); Liuqing Gao (Champaign, Illinois); Songbin Gong (Champaign, Illinois) |
| ABSTRACT | A piezoelectric thin film suspended above a carrier substrate is adapted to propagate an acoustic wave in a Lamb mode excited by a component of an electric field that is oriented in a longitudinal direction along a length of the piezoelectric thin film. A first signal electrode is located on the piezoelectric thin film and oriented in a transverse direction perpendicular to the longitudinal direction. A first ground electrode is located on the piezoelectric thin film and oriented in the transverse direction. The first ground electrode is separated from the first signal electrode by a gap in which the acoustic wave resonates. A first release window and a second release window are located at a first end and a second end of the piezoelectric thin film, respectively. Intermittent release windows are located beyond distal ends of the first signal electrode and the first ground electrode. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/248402 |
| CURRENT CPC | Impedance Networks, e.g Resonant Circuits; Resonators H03H 3/02 (20130101) H03H 9/132 (20130101) H03H 9/173 (20130101) H03H 9/176 (20130101) H03H 9/542 (20130101) H03H 9/562 (20130101) H03H 9/564 (20130101) H03H 9/568 (20130101) H03H 9/02031 (20130101) H03H 9/02228 (20130101) Original (OR) Class H03H 2003/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234562 | Pister et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Kristofer Pister (Orinda, California); Osama Ullah Khan (Berkeley, California); Bradley Wheeler (Berkeley, California) |
| ABSTRACT | A crystal-free wireless device includes a frequency calibration module and a local radio frequency (RF) oscillator having a first frequency and configured to communicate with the frequency calibration module. The crystal-free wireless device also includes a relaxation ring oscillator configured to communicate with the frequency calibration module. The relaxation ring oscillator is further configured to receive a calibration signal or periodic radio frequency packets from a wireless network and provide a reference signal to the frequency calibration module. The relaxation ring oscillator is a crystal-free oscillator. The frequency calibration module is configured to generate a calibration signal that is fed back through a Frequency Locked Loop (FLL) to the local RF oscillator to calibrate the local RF oscillator. The calibrated local RF oscillator is configured to generate a clock signal. |
| FILED | Friday, May 17, 2019 |
| APPL NO | 17/052784 |
| CURRENT CPC | Transmission H04B 1/04 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/023 (20130101) H04W 56/002 (20130101) H04W 56/0015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234605 | GANDY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Applied Minds, LLC (Burbank, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles L. GANDY (Annapolis, Maryland); Clinton Blake HOPE (Los Angeles, California); Edward Francis ADAMS (Los Angeles, California); Donald Gregory LARIVIERE (Glendale, California); Houstin L. LICHTENWALNER (Macungie, Pennsylvania) |
| ABSTRACT | Disclosed are passive reflector radio communications systems, such as for UHF frequencies or greater than UHF frequencies, and related deployment systems and devices that provide underground communications. Embodiments of the system include reflector elements to provide passive radio communications, structural frameworks to support and orient the reflector elements, methods for calculating reflector size, shape, and position corresponding to a desired wavelength, and deployment methods and devices to install the communication system at a desired location. The passive reflectors can be placed in a folded or otherwise compact mode, for transport into underground tunnels. Once at the desired installation location, the system can be installed, with the reflectors positioned appropriately for the radio frequencies used at the location. Some of the embodiments include any of vertical or horizontal foldable reflector poles, reflective sheets, reflective mesh sheets and/or ropes, inflatable reflective pucks, and rapid deployment systems and methods. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139545 |
| CURRENT CPC | Transmission H04B 7/145 (20130101) Original (OR) Class H04B 7/15507 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234882 | Lee |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | The Aerospace Corporation (El Segundo, California) |
| INVENTOR(S) | Richard M. Lee (El Segundo, California) |
| ABSTRACT | Interactive interfaces and data structures representing physical and/or visual information are provided using smart pins (also called “pins” herein). Pins representing vectors of information may be provided. For instance, in the context of cybersecurity, each pin may represent an attack vector that an adversary can use to attack a system. Each pin may have a depth meter and may move up or down according to its value in an operating range. Each pin may also have a color, a number, or both, representing its current value in the operating range. Such pins may provide both a three-dimensional representation of data that is intuitive to users. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 16/751261 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/577 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 15/005 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1433 (20130101) Original (OR) Class H04L 63/1441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210229039 | Wong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tak-Sing Wong (Penn State, Pennsylvania); Birgitt Boschitsch (Penn State, Pennsylvania) |
| ABSTRACT | A free standing liquid membrane is disclosed that can selectively separate objects based on the kinetic energy value of the objects such that either an object having a first kinetic energy value can pass through the free standing liquid membrane while retaining the membrane and/or an object having a second kinetic energy value is prevented from passing through the membrane while retaining the membrane. Advantageously, the free standing liquid membrane can remain intact for seconds to hours with multiple objects passing through the membrane. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/227535 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 61/38 (20130101) Original (OR) Class B01D 69/02 (20130101) B01D 2325/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229064 | GEITNER |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas GEITNER (Durham, North Carolina) |
| ABSTRACT | A graphene oxide adsorbent material for filtering contaminants from water is formed of graphene oxide plates cross-linked by branched polymer nanoparticles. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/159772 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/02 (20130101) Original (OR) Class B01J 20/267 (20130101) B01J 20/3071 (20130101) B01J 2220/46 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/198 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/20 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/288 (20130101) C02F 2305/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/07 (20130101) C08K 5/132 (20130101) C08K 5/405 (20130101) Compositions of Macromolecular Compounds C08L 79/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229099 | Weitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Adam R. Abate (Cambridge, Massachusetts) |
| ABSTRACT | The present invention is generally related to systems and methods for producing droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, at least one droplet is used to create a plurality of droplets, using techniques such as flow-focusing techniques. In one set of embodiments, a plurality of droplets, containing varying species, can be divided to form a collection of droplets containing the various species therein. A collection of droplets, according to certain embodiments, may contain various subpopulations of droplets that all contain the same species therein. Such a collection of droplets may be used as a library in some cases, or may be used for other purposes. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/148287 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 3/0807 (20130101) B01F 13/0062 (20130101) B01F 13/0071 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 3/502784 (20130101) B01L 2200/0636 (20130101) B01L 2200/0652 (20130101) B01L 2300/0681 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) Y10T 137/8593 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229106 | Meegoda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Jay Meegoda (Orange, New Jersey); Jitendra Kewalramani (Iselin, New Jersey) |
| ABSTRACT | Systems and methods to remediate, degrade, and/or remove pollutants within various contaminated environmental solid media that includes contaminated soils and sediments, biosolids and slurries by subjecting a mixture of the contaminated solids and a liquid to acoustic cavitation generated by more than one type of ultrasonic device. One of the ultrasonic devices operates at a low frequency and the other ultrasonic device operates at a high frequency. The system advantageously provide an efficient, sustainable, and easy to handle approach to degrade contaminant, requiring only electrical energy |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154872 |
| CURRENT CPC | Crushing, Pulverising, or Disintegrating in General; Milling Grain B02C 19/18 (20130101) Original (OR) Class Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229142 | Quigley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Quigley (Duxbury, Massachusetts); Ian Martin (Sharon, Massachusetts); Jack Rowbottom (Swansea, Massachusetts); Nicole Neff (Colorado Springs, Colorado) |
| ABSTRACT | A method for use by a system coupled to at least one sensor and at least one flow control mechanism of a gas extraction system, the system comprising at least one controller and configured for use in connection with a landfill gas extraction process for extraction of landfill gas from a landfill via the gas extraction system, the method comprising: using the at least one controller to perform: obtaining, based on at least one measurement made by the at least one sensor, at least one current value indicative of a selected characteristic of the landfill gas extraction process, determining, at discrete time intervals, whether the at least one current value satisfies at least one compliance criterion for the selected characteristic, and when it is determined that the at least one current value does not satisfy the at least one compliance criterion for the selected characteristic, performing a corrective action. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152252 |
| CURRENT CPC | Disposal of Solid Waste B09B 1/006 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/123 (20130101) E21B 47/07 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229364 | McLeod et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert R. McLeod (Boulder, Colorado); Camila Uzcategui (Boulder, Colorado); John Elliott Hergert (Boulder, Colorado); Archish Muralidharan (Boulder, Colorado) |
| ABSTRACT | Stereolithography with micron scale control of properties is described herein. In one aspect, a computer-implemented method for 3-D printing of a material can include generating a functional relation predicting one or more physical properties of the material resulting from printing parameters; algebraically or numerically solving the functional relation to generate a second functional relation predicting expected printing parameters resulting in the one or more physical properties; and printing the material via a photopolymerization printer according to the set of printing parameters determined by the second functional relation. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149423 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/264 (20170801) B29C 64/393 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2023/0691 (20130101) B29K 2105/0002 (20130101) B29K 2105/24 (20130101) B29K 2995/0094 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/02 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229987 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chi Hwan Lee (West Lafayette, Indiana); Zahyun Ku (Beavercreek, Ohio); Augustine Michael Urbas (Oakwood, Ohio); Bongjoong Kim (West Lafayette, Indiana) |
| ABSTRACT | Nanoassembly methods for producing quasi-3D plasmonic films with periodic nanoarrays of nano-sized surface features. A sacrificial layer is deposited on a surface of a donor substrate having periodic nanoarrays of nanopattern features formed thereon. A plasmon film is deposited onto the sacrificial layer and a dielectric spacer is deposited on the plasmon film. The donor substrate having the sacrificial layer, plasmon film, and dielectric spacer thereon is immersed in a bath of etchant to selectively remove the sacrificial layer such that the plasmon film and the dielectric spacer thereon adhere to the surface of the donor substrate. The dielectric spacer and the plasmon film are mechanically separated from the donor substrate to define a quasi-three dimensional (3D) plasmonic film having periodic nanoarrays of nano-sized surface features defined by the nanopattern features of the donor substrate surface. The quasi-3D plasmonic film is then applied to a receiver substrate. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/126316 |
| CURRENT CPC | Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 3/0014 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230013 | Weller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jon Mark Weller (Phoenix, Arizona); Candace Chan (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jon Mark Weller (Phoenix, Arizona); Candace Chan (Phoenix, Arizona) |
| ABSTRACT | Nanosized cubic lithium lanthanum zirconate is synthesized by forming a solution including an organic compound and compounds of lithium, lanthanum, and zirconium; drying the solution to yield a solid; and heating the solid in the presence of oxygen to pyrolyze the organic compound to yield a product comprising nanosized cubic lithium lanthanum zirconate. |
| FILED | Friday, December 04, 2020 |
| APPL NO | 17/112228 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/006 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/52 (20130101) C01P 2002/72 (20130101) C01P 2002/74 (20130101) C01P 2002/76 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2006/40 (20130101) C01P 2006/80 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) H01M 10/0562 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230028 | Doudrick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Doudrick (South Bend, Indiana); Robert Nerenberg (South Bend, Indiana); Randal Marks (South Bend, Indiana) |
| ABSTRACT | Provided are catalytic assemblies which include a hollow fiber membrane permeable to a gas; a reactive coating permeable to the gas and a contaminant; and a plurality of catalytic nanoparticles embedded in the reactive coating adapted to catalyze a reaction between the gas and the contaminant. Also provided are preparation methods for the catalytic assemblies, and use thereof for treating contaminated water. |
| FILED | Friday, November 08, 2019 |
| APPL NO | 17/269204 |
| CURRENT CPC | Separation B01D 67/0088 (20130101) B01D 69/02 (20130101) B01D 69/08 (20130101) B01D 69/145 (20130101) B01D 71/027 (20130101) B01D 2325/04 (20130101) B01D 2325/10 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/44 (20130101) B01J 35/0013 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/70 (20130101) Original (OR) Class C02F 2101/166 (20130101) C02F 2305/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230075 | Randall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clive A. Randall (University Park, Pennsylvania); Jing Guo (University Park, Pennsylvania); Amanda Baker (University Park, Pennsylvania); Michael Lanagan (University Park, Pennsylvania); Hanzheng Guo (University Park, Pennsylvania) |
| ABSTRACT | Cold sintering of materials includes using a process of combining at least one inorganic compound, e.g., ceramic, in particle form with a solvent that can partially solubilize the inorganic compound to form a mixture; and applying pressure and a low temperature to the mixture to evaporate the solvent and densify the at least one inorganic compound to form sintered materials. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226653 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/16 (20130101) B32B 7/04 (20130101) B32B 9/005 (20130101) B32B 9/045 (20130101) B32B 9/048 (20130101) B32B 15/08 (20130101) B32B 15/16 (20130101) B32B 18/00 (20130101) B32B 27/08 (20130101) B32B 27/14 (20130101) B32B 27/32 (20130101) B32B 27/34 (20130101) B32B 27/40 (20130101) B32B 27/281 (20130101) B32B 27/285 (20130101) B32B 27/286 (20130101) B32B 27/288 (20130101) B32B 27/302 (20130101) B32B 27/304 (20130101) B32B 27/308 (20130101) B32B 27/322 (20130101) B32B 27/365 (20130101) B32B 2250/02 (20130101) B32B 2262/101 (20130101) B32B 2262/106 (20130101) B32B 2264/107 (20130101) B32B 2307/20 (20130101) B32B 2307/50 (20130101) B32B 2307/202 (20130101) B32B 2307/204 (20130101) B32B 2307/546 (20130101) B32B 2307/702 (20130101) B32B 2307/704 (20130101) B32B 2307/728 (20130101) B32B 2307/732 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/447 (20130101) C04B 35/453 (20130101) C04B 35/486 (20130101) C04B 35/495 (20130101) C04B 35/634 (20130101) C04B 35/638 (20130101) C04B 35/645 (20130101) Original (OR) Class C04B 35/4682 (20130101) C04B 35/5152 (20130101) C04B 35/6263 (20130101) C04B 35/6264 (20130101) C04B 35/62222 (20130101) C04B 35/62685 (20130101) C04B 2235/77 (20130101) C04B 2235/604 (20130101) C04B 2235/656 (20130101) C04B 2235/785 (20130101) C04B 2235/3201 (20130101) C04B 2235/3203 (20130101) C04B 2235/3224 (20130101) C04B 2235/3236 (20130101) C04B 2235/3239 (20130101) C04B 2235/3256 (20130101) C04B 2235/3258 (20130101) C04B 2235/3272 (20130101) C04B 2235/3284 (20130101) C04B 2235/3291 (20130101) C04B 2235/3298 (20130101) C04B 2235/5436 (20130101) C04B 2235/6026 (20130101) C04B 2235/6562 (20130101) C04B 2235/6567 (20130101) C04B 2235/6588 (20130101) C04B 2237/068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230198 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Li (Tempe, Arizona); Eric Turner (Phoenix, Arizona) |
| ABSTRACT | Disclosed herein are metal complexes that exhibit multiple radiative decay mechanisms, together with methods for the preparation and use thereof. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212209 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) C07F 1/10 (20130101) C07F 1/12 (20130101) C07F 3/06 (20130101) C07F 13/00 (20130101) C07F 15/04 (20130101) C07F 15/006 (20130101) Original (OR) Class C07F 15/06 (20130101) C07F 15/0033 (20130101) C07F 15/0073 (20130101) C07F 15/0086 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/185 (20130101) C09K 2211/187 (20130101) C09K 2211/188 (20130101) C09K 2211/1029 (20130101) C09K 2211/1033 (20130101) C09K 2211/1044 (20130101) C09K 2211/1088 (20130101) C09K 2211/1092 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0083 (20130101) H01L 51/0084 (20130101) H01L 51/0085 (20130101) H01L 51/0087 (20130101) H01L 51/0091 (20130101) H01L 51/0092 (20130101) H01L 51/0094 (20130101) H01L 51/5012 (20130101) H01L 51/5016 (20130101) H01L 51/5028 (20130101) H01L 51/5036 (20130101) H01L 2251/5376 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 33/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230203 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cheng-Wei Tom Chang (LOGAN, Utah); JON Y TAKEMOTO (NORTH LOGAN, Utah) |
| ASSIGNEE(S) | Utah State University (North Logan, Utah) |
| INVENTOR(S) | Cheng-Wei Tom Chang (LOGAN, Utah); JON Y TAKEMOTO (NORTH LOGAN, Utah) |
| ABSTRACT | The present relates to novel bioactive amphiphilic kanamycin compounds having the general formula of: where R may be a C4 to C20 branched or straight chained alkyl group or a substituted or unsubstituted aryl group. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating and preventing various fungal and bacterial diseases. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157752 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/23 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230343 | Langer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Biocant-Center of Innovation and Biotechnology (Cantanhede, Portugal) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert S. Langer (Newton, Massachusetts); Jeffrey M. Karp (Chestnut Hill, Massachusetts); Maria Jose Maio Nunes-Pereira (Lisbon, Portugal); Ben Ouyang (Toronto, Canada); Lino da Silva Ferreira (Coimbra, Portugal); Debanjan Sarkar (Williamsville, New York) |
| ABSTRACT | Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185528 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/703 (20130101) A61K 9/7084 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/14 (20130101) C08G 18/4236 (20130101) Original (OR) Class C08G 18/4238 (20130101) C08G 18/4283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230427 | LUNT, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Richard R. LUNT, III (Williamston, Michigan); Babak BORHAN (Okemos, Michigan); Benjamin G. LEVINE (East Lansing, Michigan); Wei SHENG (Ann Arbor, Michigan); Jun ZHANG (San Luis Obispo, California); Chenchen YANG (Holt, Michigan) |
| ABSTRACT | A luminescent solar concentrator (LSC) device is provided. The LSC device has an active layer including a modified luminophore having a polymethine component including a plurality of methine groups (═CH—)n, where n is an odd integer greater than 1. A hydrogen atom (H) of one of the plurality of methine groups is replaced by one of -AR1R2 or -DR3, where A is selected from nitrogen (N), phosphorus (P), arsenic (As) and antimony (Sb) and D is selected from oxygen (O), sulfur (S), selenium (Se), and tellurium (Te), R1 and R2 are independently selected from H, aliphatic groups, and aromatic groups bound to A through a carbon atom, or R1 and R2 together form an alicyclic ring containing A, and R3 is selected from H, aliphatic groups, aromatic groups, and alicyclic groups bound to D through a carbon atom. |
| FILED | Wednesday, May 08, 2019 |
| APPL NO | 17/053493 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 23/0025 (20130101) C09B 23/0033 (20130101) C09B 23/0041 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230533 | Fan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhonghui Hugh Fan (Gainesville, Florida); Xiao Jiang (Gainesville, Florida); Trevor B. Tilly (Gainesville, Florida); John Lednicky (Gainesville, Florida); Chang-Yu Wu (Gainesville, Florida) |
| ABSTRACT | An apparatus and method are provided for performing detection of microorganisms (e.g., viruses) with high sensitivity. The apparatus and method are well suited for point-of-care (POC) testing in resource-limited regions and are capable of being operated with very little manual intervention and without the need for lab equipment. A variety of viruses can be detected with high sensitivity, including, for example, coronaviruses, Zika virus and flu viruses. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140696 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/44 (20130101) C12M 41/46 (20130101) Original (OR) Class C12M 41/48 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56916 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230593 | HAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Si-ping HAN (Duarte, California); William A. GODDARD, III (Pasadena, California); Marwa Ben HAJ SALAH (Duarte, California); Lisa SCHERER (Duarte, California); John J. ROSSI (Duarte, California) |
| ABSTRACT | Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents. The Cond-siRNA comprises a sensor strand, a core strand, and a guide strand, which crossover to form a sensor duplex and a RNAi duplex attached to each other to form a single structure. Upon binding an input strand to the sensor strand, the Cond-siRNA is activated and releases RNAi targeting a desired gene. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172461 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230601 | YAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao YAN (Chandler, Arizona); Fei ZHANG (Chandler, Arizona); Xiaodong QI (Tempe, Arizona) |
| ABSTRACT | In some embodiments, complex molecular knots with high crossing numbers are achieved by folding, following a prescribed folding order, single-stranded DNA or RNA of customized sequences into target shapes. Such complex molecular knots with high crossing numbers are useful for biomedical applications including use as immunostimulatory agents and/or protein hosts and carriers. |
| FILED | Thursday, April 25, 2019 |
| APPL NO | 17/050918 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) Original (OR) Class C12N 2310/17 (20130101) C12N 2310/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230623 | Thelan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Thelan (Columbia, Missouri); Yajin Ye (Columbia, Missouri) |
| ABSTRACT | A method of altering fatty acid and/or triacylglycerol production in plants and/or algae is provided. The method includes altering activity levels of alpha-carboxyltransferase (α-CT), a catalytic subunit of acetyl-CoA carboxylase (ACCase) by modulating an expression of at least one carboxyltransferase interaction (CTI) gene encoding at least one CTI protein. |
| FILED | Thursday, May 30, 2019 |
| APPL NO | 17/250117 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1018 (20130101) C12N 15/8213 (20130101) C12N 15/8218 (20130101) C12N 15/8247 (20130101) Original (OR) Class Enzymes C12Y 604/01002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231683 | Wandinger-Ness et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Angela Wandinger-Ness (Albuquerque, New Mexico); Tione Buranda (Albuquerque, New Mexico); Peter Simons (Albuquerque, New Mexico); Steve Young (Albuquerque, New Mexico) |
| ABSTRACT | The present invention is directed to the discovery that RapI-GTP, Racl-GTP and Flt3-L can be used as Biomarkers for the early detection of sepsis in patients suspected of a bacterial infection which presents as sepsis or is likely to produce sepsis. In particular, the present invention is directed to methods, assays and kits which may be used to distinguish sepsis (infection) from systematic inflammatory response caused by sterile inflammation in trauma patients. The method may he used to diagnose bacteria infection and/or sepsis and monitor therapy of a patient to allow modification of treatment and/or cessation of treatment. |
| FILED | Thursday, April 18, 2019 |
| APPL NO | 17/048941 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/563 (20130101) G01N 33/588 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/26 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231716 | Zhan et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee); UT-Battelle (ORNL) (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingwei Zhan (Knoxville, Tennessee); Bailu Xiao (Knoxville, Tennessee); He Yin (Knoxville, Tennessee); Fuhua Li (Knoxville, Tennessee); Wenxuan Yao (Knoxville, Tennessee); Zhi Li (Knoxville, Tennessee); Thomas King (Knoxville, Tennessee); Yilu Liu (Knoxville, Tennessee) |
| ABSTRACT | Respective phasor values are recursively computed from respective ones of a series of signal samples for a node of a power system such that each phasor value is computed from a previously computed phasor value. Frequency values are recursively computed from the phasor values for respective ones of the signal samples. Recursive computing of frequency values may include computing respective phase angle values from respective ones of the phasor values, recursively computing coefficient values for a polynomial that fits the phase angle values, and recursively computing the frequency values from the coefficient values. The samples may be generated at a sampling rate and the phasor values and the frequency values may be produced at a rate that is the same as the sampling rate. Embodiments may provide methods, apparatus and computer readable media that implement such operations. |
| FILED | Thursday, January 16, 2020 |
| APPL NO | 16/744805 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 23/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231852 | KOTOV et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Nicholas A. KOTOV (Ypsilanti, Michigan); Sharon GLOTZER (Chelsea, Michigan); Brian SHAHBAZIAN (Petaluma, California); Ryan BRANCH (Indianapolis, Indiana); Lizhi XU (Ann Arbor, Michigan); Wonjin CHOI (Ann Arbor, Michigan); Minjeong CHA (Ann Arbor, Michigan); Matthew SPELLINGS (Mercer, Tennessee) |
| ABSTRACT | Material-Sensing Light Imaging, Detection, And Ranging (LIDAR) systems optionally include a laser configured to generate a light pulse, a beam steerer configured to produce a polarization-adjusted light pulse emitted towards an object, at least one polarizer configured to polarize reflected, scattered, or emitted light returned from the object, and a processor configured to detect at least one material of the object based on an intensity and polarization of the polarized reflected, scattered or emitted light from the object. The beam steerer may include a kirigami nanocomposite. Methods are also provided, including, for example, generating a light pulse, adjusting a polarization of the light pulse to produce a polarization-adjusted light pulse emitted towards an object, polarizing reflected, scattered, or emitted light returned from the object, and detecting at least one material of the object based on an intensity and polarization of the polarized reflected, scattered or emitted light from the object. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231736 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/481 (20130101) G01S 17/89 (20130101) G01S 17/931 (20200101) Optical Elements, Systems, or Apparatus G02B 5/3025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232092 | Chrysler et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Chrysler (Tucson, Arizona); Raymond K. Kostuk (Tucson, Arizona) |
| ABSTRACT | Provided are methods for replication (copying) of volume Holographic Optical Elements (HOE) using a master hologram in optical contact with a prism, wherein the master hologram comprises distinct object and reference beam coupling elements, and wherein in the replication process light is coupled from one face of the prism and transmitted through another face of the prism using the distinct object and reference beam coupling elements. Methods for making the master hologram by sequentially forming the distinct object and reference beam coupling elements therein are provided. Further methods for encoding aperture functions directly to the master hologram are provided. Yet further methods provide for forming a copy HOE in an array configuration using a step-and-repeat method wherein the copy HOE is translated laterally by a specified distance before the next exposure is made. |
| FILED | Tuesday, May 07, 2019 |
| APPL NO | 17/053669 |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/202 (20130101) Original (OR) Class G03H 1/0248 (20130101) G03H 1/0404 (20130101) G03H 2001/0439 (20130101) G03H 2223/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232903 | Friedman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph S. Friedman (Dallas, Texas); Wesley H. Brigner (Frisco, Texas); Naimul Hassan (Dallas, Texas); Xuan Hu (Plano, Texas); Alvaro Velasquez (West Palm Beach, Florida) |
| ABSTRACT | The present disclosure provides a domain wall magnetic tunnel junction device. Integration of input spikes pushes a domain wall within a ferromagnetic track toward a magnetic tunnel junction (MTJ). An energy gradient within the track pushes the domain wall away from the MTJ by leaking accumulated energy from the input spikes. If the integrated input spikes exceed the energy leak of the gradient within a specified time period, the domain wall reaches the MTJ and reverses its resistance, producing an output spike. The leaking energy gradient can be created by a magnetic field, a trapezoidal shape of the ferromagnetic track, or nonuniform material properties in the ferromagnetic track. A feedback and feedforward crossbar configuration is disclosed that provides for a neuromorphic computing system suitable for unsupervised learning. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/211722 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Original (OR) Class G06N 3/084 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 43/02 (20130101) H01L 43/08 (20130101) H01L 45/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210232977 | Chakrabartty et al. |
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| FUNDED BY |
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| APPLICANT(S) | Shantanu Chakrabartty (St. Louis, Missouri); Oindrila Chatterjee (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Shantanu Chakrabartty (St. Louis, Missouri); Oindrila Chatterjee (St. Louis, Missouri) |
| ABSTRACT | Devices, systems, and methods related to an energy-efficient machine learning framework which exploits structural and functional similarities between a machine learning network and a general electrical network satisfying the Tellegen's theorem are described. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 16/999082 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/10 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210233242 | Kandlikar et al. |
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| FUNDED BY |
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| APPLICANT(S) | Bired Imaging, Inc. (Rochester, New York) |
| ASSIGNEE(S) | Bired Imaging, Inc. (Rochester, New York) |
| INVENTOR(S) | Satish G. Kandlikar (Rochester, New York); Donnette Dabydeen (Pittsford, New York); Lori Medeiros (Pittsford, New York); Pradyumna Phatak (Pittsford, New York); Jose Luis Gonzalez Hernandez (Rochester, New York); Alyssa Owens (East Rochester, New York) |
| ABSTRACT | Processes and techniques are disclosed to identify regions of suspected malignancy and their localization within a body part or organ. These methods rely on the analysis of infrared images to identify thermal abnormalities using image post-processing techniques, numerical modeling, iterative solutions methodology or a digital library. The methods utilize noninvasive, non-radiative and no contact infrared imaging that can be used for breast cancer screening for improved prognosis. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208001 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/015 (20130101) A61B 5/489 (20130101) A61B 5/4312 (20130101) Image Data Processing or Generation, in General G06T 7/0014 (20130101) Original (OR) Class G06T 7/30 (20170101) G06T 7/62 (20170101) G06T 17/00 (20130101) G06T 2207/10048 (20130101) G06T 2207/10088 (20130101) G06T 2207/10116 (20130101) G06T 2207/10132 (20130101) G06T 2207/20221 (20130101) G06T 2207/30068 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234070 | Brueck et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven R.J. Brueck (Albuquerque, New Mexico); Seung-Chang Lee (Albuquerque, New Mexico); Christian Wetzel (Troy, New York); Mark Durniak (Troy, New York) |
| ABSTRACT | A method of forming a semiconductor structure includes providing a substrate comprising a first material portion and a single crystal silicon layer on the first material portion. The substrate further comprises a major front surface, a major backside surface opposing the major front surface, and a plurality of grooves positioned in the major front surface. A buffer layer is deposited in one or more of the plurality of grooves. A semiconductor material is epitaxially grown over the buffer layer and in the one or more plurality of grooves, the epitaxially grown semiconductor material comprising a hexagonal crystalline phase layer and a cubic crystalline phase structure disposed over the hexagonal crystalline phase. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208905 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0243 (20130101) H01L 21/0251 (20130101) H01L 21/0254 (20130101) H01L 21/02381 (20130101) H01L 21/02395 (20130101) H01L 21/02433 (20130101) H01L 21/02458 (20130101) H01L 21/02494 (20130101) H01L 21/02502 (20130101) H01L 21/02587 (20130101) H01L 21/02609 (20130101) H01L 21/7806 (20130101) H01L 29/04 (20130101) H01L 33/04 (20130101) H01L 33/18 (20130101) H01L 33/32 (20130101) Original (OR) Class H01L 33/0075 (20130101) H01L 33/0093 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234570 | ELETREBY et al. |
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| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rashad ELETREBY (Pittsburgh, Pennsylvania); Swarun KUMAR (Pittsburgh, Pennsylvania); Osman YAGAN (Pittsburgh, Pennsylvania); Diana ZHANG (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein is a system that overcomes challenges pertaining to density and range of urban LP-WANs despite the limited capabilities of base station and client hardware. The invention proposes a novel technique that aims to disentangle and decode large numbers of interfering transmissions at a simple, single-antenna LP-WAN base station by exploiting the hardware imperfections of low-cost LP-WAN clients to its advantage. Second, the present invention exploits the correlation of sensed data collected by LP-WAN nodes to collaboratively reach a far-away base station, even if individual clients are beyond its range. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/053406 |
| CURRENT CPC | Transmission H04B 1/69 (20130101) Original (OR) Class H04B 2001/6912 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0202 (20130101) H04L 27/103 (20130101) H04L 27/144 (20130101) H04L 27/265 (20130101) Wireless Communication Networks H04W 52/0209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234742 | Brandt-Pearce et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maite Brandt-Pearce (Free Union, Virginia); Jie Lian (Charlottesville, Virginia) |
| ABSTRACT | A system and method for communication of digital data includes receiving a plurality of data bits to be transmitted, and generating an output signal for transmission by a transmitter circuit. The generating includes generating a portion of the output signal comprising values of the output signal with magnitude less than a specified threshold, the specified threshold corresponding to a specified transmitter circuit maximum output power; and generating a portion of the output signal comprising a representation of values of the output signal with magnitude greater than the specified threshold. |
| FILED | Thursday, May 09, 2019 |
| APPL NO | 17/053533 |
| CURRENT CPC | Transmission H04B 10/116 (20130101) H04B 10/556 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/2624 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210235273 | Pierson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy J. Pierson (Hanover, New Hampshire); Ronald Peterson (Brattleboro, Vermont); David F. Kotz (Lyme, New Hampshire) |
| ABSTRACT | A single-antenna device includes a single antenna, at least one processor, and at least one memory. The single-antenna device is operable to receive a signal including at least one frame. Each of said frame includes a repeating portion. The single-antenna device determines a difference of phase and amplitude of the repeating portion and further determines whether the signal is transmitted from a trusted source based at least in part on the difference of phase and amplitude of the repeating portion. |
| FILED | Friday, April 26, 2019 |
| APPL NO | 17/050764 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0284 (20130101) G01S 5/0295 (20200501) G01S 2205/07 (20200501) Information and Communication Technology Specially Adapted for the Internet of Things [IOT] G16Y 40/50 (20200101) Wireless Communication Networks H04W 4/80 (20180201) H04W 12/63 (20210101) Original (OR) Class H04W 48/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210228327 | BASARA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California); CARBON, INC. (REDWOOD CITY, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | NITASH P. BASARA (EL CERRITO, California); HEE JUENG OH (Berkeley, California); STEVEN W. HETTS (Hillsborough, California); MARIAM S. ABOIAN (SAN FRANCISCO, California); JOSEPH M. DESIMONE (REDWOOD CITY, California); GREGORY R. ROBBINS (REDWOOD CITY, California) |
| ABSTRACT | A chemical absorber to absorb and release compounds includes a porous scaffold of lattices, modified surfaces of the scaffold, wherein the modification is selected based upon an ability to bond with or release a particular compound, and a center hole in the scaffold to accommodate a guide wire. |
| FILED | Tuesday, April 30, 2019 |
| APPL NO | 17/051686 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/011 (20200501) A61F 2/0103 (20200501) Original (OR) Class A61F 2230/0067 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/262 (20130101) B01J 20/3007 (20130101) B01J 20/3285 (20130101) B01J 20/3289 (20130101) B01J 20/28042 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229080 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lucun Wang (Idaho Falls, Idaho); Dong Ding (Idaho Falls, Idaho); Yunya Zhang (Idaho Falls, Idaho); Ting He (Idaho Falls, Idaho) |
| ABSTRACT | A composite media for non-oxidative C2H6 dehydrogenation comprises an aluminosilicate zeolite matrix, and an EDH catalyst on one or more of an external surface of the aluminosilicate zeolite matrix and internal surfaces within pores of the aluminosilicate zeolite matrix. The EDH catalyst comprises one or more of Fe, Zn, Pt, Ga, alloys thereof, and oxides thereof. A C2H6 activation system, and a method of processing a C2H6-containing stream are also described. |
| FILED | Monday, July 15, 2019 |
| APPL NO | 17/260486 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/009 (20130101) B01J 8/0285 (20130101) B01J 8/0292 (20130101) B01J 29/44 (20130101) B01J 29/46 (20130101) Original (OR) Class B01J 29/405 (20130101) B01J 35/023 (20130101) B01J 35/026 (20130101) B01J 35/1019 (20130101) B01J 35/1038 (20130101) B01J 2208/00017 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/26 (20130101) C01B 2203/041 (20130101) C01B 2203/0277 (20130101) Acyclic or Carbocyclic Compounds C07C 5/3335 (20130101) C07C 5/3337 (20130101) C07C 2529/44 (20130101) C07C 2529/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229133 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sortera Alloys, Inc. (Forth Worth, Texas) |
| ASSIGNEE(S) | Sortera Alloys, Inc. (Forth Worth, Texas) |
| INVENTOR(S) | Nalin Kumar (Fort Worth, Texas); Manuel Gerardo Garcia, JR. (Lexington, Kentucky); Isha Kamleshbhai Maun (Arlington, Texas) |
| ABSTRACT | A material sorting system sorts materials utilizing an x-ray fluorescence and/or a vision system that implements a machine learning system in order to identify or classify each of the materials, which are then sorted into separate groups based on such an identification or classification determining that the materials are composed of either wrought aluminum, extruded aluminum, or cast aluminum. The system is capable of sorting between cast aluminum alloys and also between wrought aluminum alloys. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/227245 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229217 | Rodelas et al. |
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| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Rodelas (Albuquerque, New Mexico); Donald F. Susan (Albuquerque, New Mexico); Andrew Kustas (Albuquerque, New Mexico) |
| ABSTRACT | The present invention relates to methods of enhancing the surface properties of soft alloys by using a high energy beam. In particular embodiments, the methods can also allow for beam-based welding of such soft alloys to another metal component. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157550 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/24 (20130101) B23K 26/323 (20151001) Original (OR) Class B23K 2103/18 (20180801) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 15/011 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 3/02 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/147 (20130101) H01F 41/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229315 | LEE et al. |
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| FUNDED BY |
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| APPLICANT(S) | San Diego State University (San Diego, California) |
| ASSIGNEE(S) | UNITED STATES OF AMERICA has certain rights in the invention from DOE Grant No. DE-SC0008581 (Washington, District of Columbia) |
| INVENTOR(S) | GEUNTAK LEE (Seoul, South Korea); Eugene Olevsky (San Diego, California); Charles Maniere (Toulouse, France) |
| ABSTRACT | The invention relates to a process for fabricating complex mechanical shapes from metal or ceramic, and in particular to fabricating complex mechanical shapes using a pressure-assisted sintering technique to address problems relating to variations in specimen thickness and tooling, or densification gradients, by 3-D printing of a sacrificial, self-destructing powder mold is created using e.g. alumina and swellable binders such as polysaccharides. The binder-free sintering powder that forms the manufactured item is injected into the mold, and high pressure is applied. The powder assembly can then be sintered by any pressure assisted technique to full densification and the self-destructing mold allows the release of the fully densified complex manufactured item. |
| FILED | Friday, April 26, 2019 |
| APPL NO | 17/050835 |
| CURRENT CPC | Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 5/77 (20170201) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/04 (20130101) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) B28B 7/342 (20130101) Original (OR) Class B28B 7/346 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/10 (20130101) C04B 35/48 (20130101) C04B 35/6455 (20130101) C04B 2235/3217 (20130101) C04B 2235/3244 (20130101) C04B 2235/3246 (20130101) C04B 2235/6026 (20130101) C04B 2235/6562 (20130101) C04B 2235/6567 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229327 | AITHARAJU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Venkateshwar R. AITHARAJU (Troy, Michigan); William R. RODGERS (Bloomfield Township, Michigan); Selina X. ZHAO (Rochester Hills, Michigan); Terrence WATHEN (Sterling Heights, Michigan) |
| ABSTRACT | A method of manufacturing a composite component according to various aspects of the present disclosure includes disposing a fiber preform in a mold. The fiber preform includes a first portion having a first edge and a second portion having a second edge. The first edge and the second edge cooperate to at least partially define a gap. One of the first portion or the second portion includes a first ferromagnetic material and the other of the first portion or the second portion includes a first magnetic or magnetizable component. The method further includes closing the gap by generating a magnetic field from the first magnetic or magnetizable component. The method further includes injecting a polymer precursor into the mold. The method further includes forming the composite component by solidifying the polymer precursor to form a polymer. The composite component includes the fiber preform and the polymer. |
| FILED | Monday, January 27, 2020 |
| APPL NO | 16/773516 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 31/008 (20130101) B29C 33/16 (20130101) B29C 33/32 (20130101) B29C 45/14008 (20130101) B29C 45/14065 (20130101) Original (OR) Class B29C 2045/14131 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229997 | BAGRI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prashant BAGRI (Hillsboro, Oregon); Sheng DAI (Knoxville, Tennessee); Huimin LUO (Knoxville, Tennessee) |
| ABSTRACT | A method for converting amorphous boron nitride to crystalline boron nitride, the method comprising immersing the amorphous boron nitride into anhydrous molten magnesium chloride maintained within a temperature range of 720° C.-820° C. while the amorphous boron nitride is cathodically polarized at a voltage within a range of −2.2V to −2.8V for a period of time of at least 2 minutes to result in conversion of the amorphous boron nitride to the crystalline form. Also described herein is a method for converting an amorphous carbon material to a crystalline carbon material, the method comprising immersing said amorphous carbon material into anhydrous molten magnesium chloride maintained within a temperature range of 780° C.-820° C. while the amorphous carbon material is cathodically polarized at a voltage within a range of −2.2V to −2.8V for a period of time of at least 2 minutes to result in conversion of the amorphous carbon material to the crystalline form. |
| FILED | Tuesday, January 28, 2020 |
| APPL NO | 16/774684 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 21/064 (20130101) Original (OR) Class Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 5/32 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/02 (20130101) C01P 2002/74 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230076 | Petrie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian M. Petrie (Oak Ridge, Tennessee); Brian C. Jolly (Oak Ridge, Tennessee); Kurt A. Terrani (Oak Ridge, Tennessee); Michael P. Trammell (Oak Ridge, Tennessee) |
| ABSTRACT | An improved method for embedding one or more sensors in SiC is provided. The method includes depositing a binder onto successive layers of a SiC powder feedstock to produce a dimensionally stable green body have a true-sized cavity. A sensor component is then press-fit into the true-sized cavity. Alternatively, the green body is printed around the sensor component. The assembly (the green body and the sensor component) is heated within a chemical vapor infiltration (CVI) chamber for debinding, and a precursor gas is introduced for densifying the SiC matrix material. During infiltration, the sensor component becomes bonded to the densified SiC matrix, the sensor component being selected to be thermodynamically compatible with CVI byproducts at elevated temperatures, including temperatures in excess of 1000° C. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/142315 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/63 (20130101) C04B 35/565 (20130101) C04B 37/021 (20130101) Original (OR) Class C04B 37/042 (20130101) C04B 2235/3826 (20130101) C04B 2235/6026 (20130101) C04B 2237/62 (20130101) C04B 2237/365 (20130101) C04B 2237/403 (20130101) C04B 2237/408 (20130101) Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 11/245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230398 | Zhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yu Zhu (Copley, Ohio); Bryan D. Vogt (State College, Pennsylvania); Clinton J. Taubert (Akron, Ohio); Kun Chen (Akron, Ohio) |
| ASSIGNEE(S) | THE UNIVERSITY OF AKRON (Akron, Ohio) |
| INVENTOR(S) | Yu Zhu (Copley, Ohio); Bryan D. Vogt (State College, Pennsylvania); Clinton J. Taubert (Akron, Ohio); Kun Chen (Akron, Ohio) |
| ABSTRACT | In one or more embodiments, the present invention is directed to an electrically conductive polymer composition comprising a conductive metal filler material comprising a plurality of metal particles and one or more carbon-based filler material substantially homogenously dispersed throughout a polymer matrix, wherein the aspect ratio of the one or more carbon-based filler material is at least ten times greater than the aspect ratio of the conductive metal filler material comprising a plurality of metal particles. In one or more embodiment, the carbon-based filler material will comprise at least one of carbon nanotubes, multi-walled carbon nanotubes and edge-functionalized graphene. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/104283 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/203 (20130101) C08J 3/205 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/08 (20130101) C08K 3/041 (20170501) C08K 7/00 (20130101) C08K 13/04 (20130101) Original (OR) Class C08K 2003/0806 (20130101) C08K 2201/001 (20130101) C08K 2201/004 (20130101) C08K 2201/005 (20130101) C08K 2201/011 (20130101) C08K 2201/014 (20130101) C08K 2201/016 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/22 (20130101) H01B 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230444 | PEARSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| INVENTOR(S) | Ryan Michael PEARSON (Berkeley, California); Matthew David RYAN (Berkeley, California); Garret MIYAKE (Fort Collins, Colorado) |
| ABSTRACT | Polymer composite photonic crystal materials are disclosed as coatings and topcoats which have high reflection (>30%) in a specific range of the electromagnetic spectrum, such as ultraviolet (<400 nm), visible (Vis, 400 nm-700 nm), or near-infrared radiation range (NIR, 700-2000 nm), and relatively low reflection (<20% reflection) in a second, different range of the electromagnetic spectrum. Surprisingly, it was found that through a formulation and additives approach, the optical properties of polymer composite photonic crystal films can be selectively modified from a variety of different coating methods, including spray deposition. |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 16/964463 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 4/00 (20130101) C09D 5/002 (20130101) C09D 7/41 (20180101) C09D 7/61 (20180101) C09D 133/10 (20130101) C09D 155/005 (20130101) Original (OR) Class C09D 175/14 (20130101) C09D 181/02 (20130101) Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230592 | Scheinberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David A. Scheinberg (New York, New York); Michael R. McDevitt (Bronx, New York); Carlos H. Villa (Philadelphia, Pennsylvania); J. Justin Mulvey (New York, New York) |
| ASSIGNEE(S) | Sloan-Kettering Institute for Cancer Research (New York, New York) |
| INVENTOR(S) | David A. Scheinberg (New York, New York); Michael R. McDevitt (Bronx, New York); Carlos H. Villa (Philadelphia, Pennsylvania); J. Justin Mulvey (New York, New York) |
| ABSTRACT | Provided herein are single wall nanotube constructs to which are convalently linked a plurality of a bifunctional chelator, a therapeutic or a diagnostic radionuclide chelated to each bifunctional chelator and a plurality of morpholino oligonucleotides conjugated to the single wall nanotube. Also provided are single wall nanotube complexes which have the morpholino oligonucleotides on the single wall nanotube constructs hybridized to other morpholino oligonucleotides. The other morpholino oligonucleotides are each conjugated to a therapeutic antibody. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/158132 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6849 (20170801) A61K 51/1027 (20130101) A61K 51/1093 (20130101) A61K 51/1203 (20130101) A61K 51/1248 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 16/30 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) C07K 2317/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/351 (20130101) C12N 2310/3233 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230643 | Steele et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James L. Steele (Madison, Wisconsin); Jeff R. Broadbent (Amalga, Utah) |
| ABSTRACT | An engineered bacterium for producing ethanol from one or more carbohydrates is disclosed. The bacterium can be made by (a) inactivating within a Lactobacillus casei bacterium one or more endogenous genes encoding a lactate dehydrogenase; or (b) introducing into a Lactobacillus casei bacterium one or more exogenous genes encoding a pyruvate decarboxylase and one or more exogenous genes encoding an alcohol dehydrogenase II; or (c) performing both steps (a) and (b). The resulting engineered bacterium produces significantly more ethanol than the wild-type Lactobacillus casei bacterium, and can be used in producing ethanol from a substrate such as biomass that includes carbohydrates. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228170 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/88 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/065 (20130101) Original (OR) Class Enzymes C12Y 101/01001 (20130101) C12Y 101/01027 (20130101) C12Y 401/01001 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231387 | Lance et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Blake Lance (Albuquerque, New Mexico); Clifford K. Ho (Albuquerque, New Mexico); Kevin Albrecht (Albuquerque, New Mexico) |
| ABSTRACT | The present disclosure is directed to dry cooling systems and methods that use particles to drastically increase air-side heat transfer for dry cooling. The systems may be used for the dry cooling of power plants and other industrial processes that require cooling. The systems further use moving particles to remove heat from a hot fluid or system through a heat exchanger of some form. This may be a fluidized bed or moving bed heat exchanger, or similar concept. The moving particles are then cooled easily with exposure to air, the ultimate heat sink. Particles enable thermal ‘cold’ storage that can increase cooling and power cycle efficiencies, especially in arid climates, by cooling particle storage at night. This novel cooling method decreases both capital and operating expenses compared with traditional air-cooled units by a factor of four and two, respectively. |
| FILED | Thursday, May 02, 2019 |
| APPL NO | 16/618711 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231544 | Busenitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Clark Busenitz (Overland Park, Kansas); Weston A. McGuire (Overland Park, Kansas) |
| ABSTRACT | An assembly for shock testing a specimen, the assembly including first and second opposing brackets and opposing lower and upper caps. The opposing brackets include lower and upper angled surfaces. The lower cap includes lower angled surfaces configured to engage the lower angled surfaces of the left and right brackets. The upper cap includes upper angled surfaces configured to engage the upper angled surfaces of the left and right brackets. The first and second brackets are configured to be drawn toward each other via fasteners, thereby wedging the lower and upper caps toward each other against the specimen. |
| FILED | Tuesday, January 28, 2020 |
| APPL NO | 16/774354 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 7/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/04 (20130101) Original (OR) Class G01N 3/30 (20130101) G01N 2203/026 (20130101) G01N 2203/0256 (20130101) G01N 2203/0405 (20130101) G01N 2203/0482 (20130101) G01N 2203/0676 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231628 | Nenoff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tina M. Nenoff (Albuquerque, New Mexico); Dorina F. Sava Gallis (Albuquerque, New Mexico); Dayton Jonathan Vogel (Albuquerque, New Mexico); Jessica Rimsza (Albuquerque, New Mexico) |
| ABSTRACT | The present invention relates to a metal-organic framework composition, as well as constructs and methods thereof. In one particular example, the composition is employed to detect the presence of an acid gas. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/142443 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 33/0037 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210233688 | Klausner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James F. Klausner (Haslett, Michigan); Renwei Mei (Gainesville, Florida); Ayyoub Mehdizadeh Momen (Knoxville, Tennessee); Kyle Allen (San Ramon, California) |
| ABSTRACT | Disclosed herein is a method comprising disposing a first particle in a reactor; the first particle being a magnetic particle or a particle that can be influenced by a magnetic field, an electric field or a combination of an electrical field and a magnetic field; fluidizing the first particle in the reactor; applying a uniform magnetic field, a uniform electrical field or a combination of a uniform magnetic field and uniform electrical field to the reactor; elevating the temperature of the reactor; and fusing the first particles to form a monolithic solid. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/210742 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/745 (20130101) B01J 37/0009 (20130101) B01J 37/0221 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/50 (20170801) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/515 (20130101) C04B 38/0038 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/01 (20130101) Original (OR) Class H01F 41/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234214 | PUGLIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Frank PUGLIA (East Greenwich, Rhode Island); Ralph ROARK (North Stonington, Connecticut); Gregory J. MOORE (Griswold, Connecticut); Arthur DOLBEY (East Greenwich, Rhode Island); LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); EAGLEPICHER TECHNOLOGIES, LLC (St. Louis, Missouri) |
| ASSIGNEE(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); EAGLEPICHER TECHNOLOGIES, LLC (St. Louis, Missouri) |
| INVENTOR(S) | Frank PUGLIA (East Greenwich, Rhode Island); Ralph ROARK (North Stonington, Connecticut); Gregory J. MOORE (Griswold, Connecticut); Arthur DOBLEY (East Greenwich, Rhode Island); Thomas J. MCCARVILLE (Tracy, California); John CHANG (Danville, California); Jacquelyn N. ETTER (Livermore, California); Jack KOTOVSKY (Alameda, California); Rudy ROBLES (Livermore, California); Eric M. ZIEBARTH (San Leandro, California) |
| ABSTRACT | The present disclosure relates to an energy module having a plurality of energy generating cells, and at least one cooling plate having opposing surfaces. The cooling plate is disposed between an adjacent pair of the energy generating cells such that the opposing surfaces of the cooling plate are in contact with surfaces of the adjacent pair of energy generating cells. The cooling plate has at least one coolant flow channel configured to receive a coolant flow therethrough to limit propagation of heat from one to the other of either one of the adjacent pair of energy generating cells when either one of the adjacent pair of energy generating cells fails. |
| FILED | Thursday, May 02, 2019 |
| APPL NO | 17/052760 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 1/0316 (20130101) F28D 2021/0029 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 3/12 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/613 (20150401) H01M 10/6555 (20150401) H01M 10/6557 (20150401) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234371 | Arnold et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Arnold (Danville, California); Michael Sankur (Emeryville, California) |
| ABSTRACT | Embodiments relate to an operating system coupled to and controlling at least one Distributed Energy Resource (DER) in a smart grid and includes an electricity distribution network and a 2-dimensional Extremum Seeking (2D-ES) controller coupled to network. The electricity distribution network has first and second inputs and one output and maps all active power and reactive power inputs to the smart grid providing measurements of an objective function. The 2D-ES controller controls the DER and includes an active power loop and a reactive power loop. The active power loop is in communication with the first input and the output, governs active power contribution, and receives measurements of the objective function which contain static and oscillatory components. The reactive power loop is in communication with the second input and the output, governs reactive power contribution, and receives measurements of the objective function which contain static and oscillatory components. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/145259 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/042 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/18 (20130101) Original (OR) Class H02J 3/32 (20130101) H02J 3/381 (20130101) H02J 2300/24 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210234424 — APPARATUS AND METHODS FOR MANUFACTURING HIGH-DENSITY COIL WITH FORMED COOLING CHANNELS
| US 20210234424 | Brown |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ian Patrick Brown (Evanston, Illinois) |
| ASSIGNEE(S) | ILLINOIS INSTITUTE OF TECHNOLOGY (Chicago, Illinois) |
| INVENTOR(S) | Ian Patrick Brown (Evanston, Illinois) |
| ABSTRACT | A conductive coil for an electric application having a cooling channel for a coolant liquid or gas. The coil includes a wire winding of a plurality of wire turns. The wire winding is compressed about a cooling channel which is disposed between adjacent turn segments of the plurality of wire turns. The wire winding is formed and pressed against a shaping element to form the coolant channel within the compressed winding. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157396 |
| CURRENT CPC | Dynamo-electric Machines H02K 1/20 (20130101) H02K 3/24 (20130101) Original (OR) Class H02K 3/28 (20130101) H02K 15/0093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210228550 | Abel-Santos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada (Las Vegas, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ernesto Abel-Santos (Las Vegas, Nevada); Norma Ramirez (Guanajuato, Mexico); Marc Liggins (Irvine, California) |
| ABSTRACT | Provided herein are materials and methods useful for reducing, preventing, and/or inhibiting germination of C. perfringens spores, including methods for inhibiting C. perfringens germination to reduce necrotizing enteritis (NE, also referred to as necrotic enteritis) in animals. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/168155 |
| CURRENT CPC | Fodder A23K 20/195 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/0056 (20130101) A61K 9/1611 (20130101) A61K 31/428 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230097 | BIRESAW et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | GIRMA BIRESAW (PEORIA, Illinois); STEVEN C. CERMAK (GALESBURG, Illinois); HELEN N. LEW (WYNNEWOOD, Pennsylvania) |
| ABSTRACT | A branched estolide compound of the formula: wherein x and y are equal to 1 or greater; wherein x+y=14; wherein n is 0, 1, or greater than 1; wherein R is H or wherein R=C1 to C18 straight alcohols or C4 to C12 branched alcohols; wherein R1 is a residual fragment of octanoic, decanoic, lauric, coconut, myristic, palmitic, stearic, oleic, iso-stearic or iso-oleic acids. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157046 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 69/675 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230203 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cheng-Wei Tom Chang (LOGAN, Utah); JON Y TAKEMOTO (NORTH LOGAN, Utah) |
| ASSIGNEE(S) | Utah State University (North Logan, Utah) |
| INVENTOR(S) | Cheng-Wei Tom Chang (LOGAN, Utah); JON Y TAKEMOTO (NORTH LOGAN, Utah) |
| ABSTRACT | The present relates to novel bioactive amphiphilic kanamycin compounds having the general formula of: where R may be a C4 to C20 branched or straight chained alkyl group or a substituted or unsubstituted aryl group. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating and preventing various fungal and bacterial diseases. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157752 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/23 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230643 | Steele et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James L. Steele (Madison, Wisconsin); Jeff R. Broadbent (Amalga, Utah) |
| ABSTRACT | An engineered bacterium for producing ethanol from one or more carbohydrates is disclosed. The bacterium can be made by (a) inactivating within a Lactobacillus casei bacterium one or more endogenous genes encoding a lactate dehydrogenase; or (b) introducing into a Lactobacillus casei bacterium one or more exogenous genes encoding a pyruvate decarboxylase and one or more exogenous genes encoding an alcohol dehydrogenase II; or (c) performing both steps (a) and (b). The resulting engineered bacterium produces significantly more ethanol than the wild-type Lactobacillus casei bacterium, and can be used in producing ethanol from a substrate such as biomass that includes carbohydrates. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228170 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/88 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/065 (20130101) Original (OR) Class Enzymes C12Y 101/01001 (20130101) C12Y 101/01027 (20130101) C12Y 401/01001 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230673 | PEREZ de LEON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia); THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ADALBERTO A. PEREZ de LEON (WAKE FOREST, North Carolina); MARIA D. ESTEVE-GASENT (COLLEGE STATION, Texas); PAMELA J. FERRO (BRYAN, Texas); JOSEPH J. MODARELLI (BLUFFTON, Texas) |
| ABSTRACT | Kits, methods, and material for use in detecting tick-borne microorganism(s) are provided herein. One is able to detect DNA from several different species of microorganisms from samples (bodily fluid, tissue, etc.) from ticks and/or mammals to determine if one or more of the microorganisms has infected the tick and/or mammal. The assay uses PCR techniques with a multiple primers and probes. The microorganisms can be in the Borrelial Layer, the Rickettsiales Layer, and/or the Babesial Layer. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/228749 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 2600/16 (20130101) C12Q 2600/112 (20130101) C12Q 2600/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230777 | Reed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Jess Dreher Reed (Verona, Wisconsin); Christian Gerald KRUEGER (Cambridge, Wisconsin); Emilia ALFARO-VIQUEZ (Madison, Wisconsin); Sergio MADRIGAL-CARBALLO (Madison, Wisconsin); Hilary Urena SABORIO (Madison, Wisconsin); Sundaram GUNASEKARAN (Madison, Wisconsin) |
| ABSTRACT | Composite nanofibers comprising polymers and tannins, methods of making same, and methods of use. The nanofibers include a polymer, such as a synthetic polymer, and a tannin. The tannin can include condensed tannins (proanthocyanidins) and/or hydrolyzable tannins. The nanofibers exhibit a number of structural and functional characteristics, such as enhanced swelling in aqueous liquid, enhanced antibacterial activity, enhanced bacterial adsorption, enhanced fibroblast adhesion, enhanced fibroblast proliferation, and enhanced surface coating of silver nanoparticles, among others. The nanofibers can be made by electrospinning a solvent mixture comprising the synthetic polymer and the tannin in a solvent. The nanofibers can be used in methods of isolating cells, methods of filtration, and methods of detecting cells, among others. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 16/898633 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0266 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 11/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 8/14 (20130101) D01F 8/18 (20130101) Original (OR) Class Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210231646 | Stanciu-Gregory et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Lia Antoaneta Stanciu-Gregory (West Lafayette, Indiana); Jan P. Allebach (West Lafayette, Indiana); George Tsu-Chih Chiu (West Lafayette, Indiana); Lixby S. Diaz (West Lafayette, Indiana); Min Zhao (West Lafayette, Indiana) |
| ABSTRACT | A μPAD may include a substrate comprising a substrate. The μPAD may further include a non-polar material printed on a surface of the substrate such that a portion the surface is exposed. The exposed portion may include a receiving area, a plurality of test areas, and a plurality of channels disposed between the receiving area and the test areas. The μPAD may further include colorimetric sensors respectively positioned in the test areas. The channel regions may be configured to receive an analyte solution from the receiving area and direct the analyte solution to the colorimetric sensors. A system may perform image processing on captured images of the μPAD to provide multiplexed analysis of analyte solutions applied to the μPAD. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161287 |
| CURRENT CPC | Printing, Duplicating, Marking, or Copying Processes; Colour Printing, B41M 1/12 (20130101) B41M 3/006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/79 (20130101) G01N 33/52 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210228404 | Maier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Reia, LLC (Lyme, New Hampshire) |
| ASSIGNEE(S) | Reia, LLC (Lyme, New Hampshire) |
| INVENTOR(S) | Kaitlin E. Maier (Darien, Connecticut); Ariana M. Sopher (Somerville, Massachusetts); Meegan P. Daigler (Portland, Maine) |
| ABSTRACT | A pessary device has a support portion, a stem and a loop attached to the stem to facilitate manipulation and control of the pessary device. The loop portion is flexible and provides a hole for receipt of a finger of the person inserting or removing the pessary device. The loop portion preferably includes a taper and/or a dimpled end to facilitate the use of a finger or an applicator for insertion of the device deeper into the vagina. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/210576 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 6/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210229142 | Quigley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Loci Controls, Inc. (Wareham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Quigley (Duxbury, Massachusetts); Ian Martin (Sharon, Massachusetts); Jack Rowbottom (Swansea, Massachusetts); Nicole Neff (Colorado Springs, Colorado) |
| ABSTRACT | A method for use by a system coupled to at least one sensor and at least one flow control mechanism of a gas extraction system, the system comprising at least one controller and configured for use in connection with a landfill gas extraction process for extraction of landfill gas from a landfill via the gas extraction system, the method comprising: using the at least one controller to perform: obtaining, based on at least one measurement made by the at least one sensor, at least one current value indicative of a selected characteristic of the landfill gas extraction process, determining, at discrete time intervals, whether the at least one current value satisfies at least one compliance criterion for the selected characteristic, and when it is determined that the at least one current value does not satisfy the at least one compliance criterion for the selected characteristic, performing a corrective action. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152252 |
| CURRENT CPC | Disposal of Solid Waste B09B 1/006 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/123 (20130101) E21B 47/07 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210230203 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cheng-Wei Tom Chang (LOGAN, Utah); JON Y TAKEMOTO (NORTH LOGAN, Utah) |
| ASSIGNEE(S) | Utah State University (North Logan, Utah) |
| INVENTOR(S) | Cheng-Wei Tom Chang (LOGAN, Utah); JON Y TAKEMOTO (NORTH LOGAN, Utah) |
| ABSTRACT | The present relates to novel bioactive amphiphilic kanamycin compounds having the general formula of: where R may be a C4 to C20 branched or straight chained alkyl group or a substituted or unsubstituted aryl group. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating and preventing various fungal and bacterial diseases. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157752 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/23 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210231385 | Hwang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wichita State University (Wichita, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gisuk Hwang (Wichita, Kansas); Rajeev Nair (Wichita, Kansas) |
| ABSTRACT | In a method of forming a porous wick structure, a space is filled with particles formed from electrically conductive material such that the particles contact one another at contact points within the space. The particles are compressed within the space at a pressure of less than 0.1 MPa. While compressing the particles, electrical current is imparted through the particles in to simultaneously form bonds between adjacent particles at points of contact between the particles. The bonds fix the particles in position with respect to one another such that pores are defined between adjacent particles. A porous wick structure can be formed by this method. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157124 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/02 (20130101) B22F 5/10 (20130101) B22F 2202/06 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/046 (20130101) Original (OR) Class F28D 15/0233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210234083 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sang H. Choi (Poquoson, Virginia); Adam J. Duzik (Yorktown, Virginia) |
| ABSTRACT | Systems, methods, and devices of the various embodiments provide for microfabrication of devices, such as semiconductors, thermoelectric devices, etc. Various embodiments may include a method for fabricating a device, such as a semiconductor (e.g., a silicon (Si)-based complementary metal-oxide-semiconductor (CMOS), etc.), thermoelectric device, etc., using a mask. In some embodiments, the mask may be configured to allow molecules in a deposition plume to pass through one or more holes in the mask. In some embodiments, molecules in a deposition plume may pass around the mask. Various embodiments may provide thermoelectric devices having metallic junctions. Various embodiments may provide thermoelectric devices having metallic junctions rather than junctions formed from semiconductors. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140548 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/14 (20130101) C23C 14/042 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/16 (20130101) H01L 35/20 (20130101) H01L 35/30 (20130101) H01L 35/34 (20130101) Original (OR) Class H01L 35/325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20210232695 | Eldefrawy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karim Eldefrawy (Palo Alto, California); Hassen Saidi (Palo Alto, California); Michael E. Locasto (Lebanon, New Jersey); Norrathep Rattanavipanon (Irvine, California) |
| ABSTRACT | In general, this disclosure describes techniques for replacing target cryptographic primitives in executable binary files with other, potentially more secure, cryptographic primitives. In some examples, a computing system for augmenting cryptographic executables includes a locator to determine if an executable program in an executable binary file includes a target cryptographic primitive. The computing system can include a patch generator to generate patch instructions in response to a determination by the locator that the executable program includes the target cryptographic primitive. The patch instructions cause the executable program to execute a replacement cryptographic primitive instead of the target cryptographic primitive. A rewriter engine of the computing system can modify, based on the patch instructions, the executable program to generate a modified executable binary file. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 16/938664 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30032 (20130101) G06F 21/602 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20210231558 | PAVLICHENKO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ida PAVLICHENKO (Watertown, Massachusetts); Elijah SHIRMAN (Arlington, Massachusetts); Sören BRANDT (Somerville, Massachusetts); Timothy Sheung Bun WONG (Richmond Hill, Canada); Austin TRIPP (North York, Canada); Joanna AIZENBERG (Boston, Massachusetts) |
| ABSTRACT | A method for analyzing a volatile liquid mixture is described. The method includes providing a sensor, and placing the sensor within a chamber. The mixture is stored in the chamber for a duration sufficient to achieve a series of dynamic non-equilibrium mass-transfer processes: (1) spreading and wetting of the analyte on at least a portion of the bottom-inside surface of the chamber from the source of the injection, (2) evaporation of at least a portion of the analyte liquid into a vaporized analyte, (3) convection and/or diffusion of the vaporized analyte through the chamber to the sensor, and (4) sorption of the vaporized analyte on the sensor. The sensor detects, over time, a plurality of non-equilibrium spectral responses, each corresponding to at least one compositional change in the analyte liquid. The method further includes machine learning algorithms to measure or predict the compositional change and/or presence of contaminants. |
| FILED | Thursday, May 16, 2019 |
| APPL NO | 17/054868 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) Original (OR) Class G01N 21/41 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210230117 | Ohlmeyer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael Ohlmeyer (New York, New York); Dongming Cai (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Ohlmeyer (New York, New York); Dongming Cai (New York, New York) |
| ABSTRACT | A genus of dihydropyridine chemical modulators of synaptojanin is disclosed. These modulators are selective inhibitors of synaptojanin 1 and may be used to treat cognitive impairment or traumatic brain injury, including promoting regeneration in cases of traumatic brain injury, or for treating neurodegenerative disorders. |
| FILED | Tuesday, November 20, 2018 |
| APPL NO | 16/763962 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 211/90 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20210228655 | O'Toole et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); Dartmouth-Hitchcock Clinic (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George A. O'Toole (Hanover, New Hampshire); Juliette C. Madan (Lyme, New Hampshire) |
| ABSTRACT | The present disclosure relates to a method of altering intestinal microbiome in a patient having cystic fibrosis comprising administering at least one of Bifidobacterium and/or Bacteroides to a patient and allowing the Bifidobacterium and/or Bacteroides to alter the intestinal microbiome. |
| FILED | Tuesday, March 26, 2019 |
| APPL NO | 16/979824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 35/744 (20130101) A61K 35/745 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
General Services Administration (GSA)
| US 20210232707 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tenet 3, LLC (Dayton, Ohio) |
| ASSIGNEE(S) | Tenet 3, LLC (, None) |
| INVENTOR(S) | Kelce S. Wilson (Murphy, Texas); Jeff A. Hughes (Dayton, Ohio); Tyler J. Moody (Fairborn, Ohio); Derek E. Doran (Hilliard, Ohio); Gary R. Tuttle (Middletown, Ohio); Joel B. Rieman (Xenia, Ohio) |
| ABSTRACT | A permissioned blockchain, using off-chain storage, provides advantages over blockchains that rely on consensus and/or store information within the blockchain. Advantages include enhanced viability, compactness, and the ability to register material with distribution limitations (e.g., military classified). Examples create an immutable public record of data signatures that confirm when data is intact, without distributing the data itself, so that widespread availability of the blockchain (beyond those privileged to see the data) advantageously increases the size of the community that is able to detect spoofing or forgery attempts. A permissioning entity limits submissions to manage blockchain growth, foreclosing problematic material that may risk long-term viability. Examples render blockchain operations resistant to advanced persistent threats (APTs), leverage digital signatures as additional trust elements for high-risk data, link records to track pedigree and enable identification of superseded (obsolete) data, and leverage out-of-band date proof to enable independent verification of integrity and no-later-than data-of-existence. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139694 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/64 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3239 (20130101) H04L 9/3247 (20130101) H04L 2209/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20210229930 | Potter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas C. Potter (Oak Hill, Virginia); Daniel Mark (Sterling, Virginia) |
| ABSTRACT | A sorting machine can include an output bin that includes a transport belt to transport a delivery item (e.g., a letter) from a distribution belt at a first speed. The output bin can include a braking roller to reduce the speed of the delivery item by operating at a second tangential speed that is slower than the first speed. The output bin can also include an auger assembly to apply a force to move at least the trailing portion of the item in a manner that clears the path to the braking roller for additional delivery items. The output bin can also include a bumper pad to stop the delivery item, where the delivery item is stopped against the bumper pad after being slowed down by contact with the braking roller. The slowed speed causes the delivery item to come to rest approximately in alignment with additional delivery items. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/160555 |
| CURRENT CPC | Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 47/31 (20130101) B65G 47/49 (20130101) B65G 47/261 (20130101) Original (OR) Class B65G 2201/0285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 29, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page