FedInvent™ Patent Applications
Application Details for Thursday, August 19, 2021
This page was updated on Friday, August 20, 2021 at 12:09 PM GMT
Department of Health and Human Services (HHS)
| US 20210251200 | Carlson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Recombinetics, Inc. (Eagan, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel F. Carlson (Woodbury, Minnesota); Staci Lyn Solin (Minneapolis, Minnesota) |
| ABSTRACT | The present disclosure provides methods to produce non-human animal models for diseases that have a poor life-expectancy. The animal models provided herein are the result of gene editing to result in genetic lesions that recapitulate human diseases by virtue of introgressing lethal, dominant negative or non-functional mutations in animal genomes corresponding to those responsible for human diseases. In some cases, the genomic edit may result in a low number of pregnancies carried to term and/or a failure to thrive phenotype with those born failing to survive to sexual maturity. The present disclosure provides methods to produce non-chimeric animals containing a detrimental genetic lesion from healthy chimeric animals. In this method, the chimeric animals are derived from cells in which the genetic lesion is made with the defect being complemented by the genome of an animal that is gametogenically deficient (cannot produce gametes) and cannot pass on its own genes. Thus, the gametes of the chimera are completely derived from the edited animal. When a male and female chimera are mated with each other, the offspring are 100% of the edited genome. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/187121 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Original (OR) Class A01K 2217/075 (20130101) A01K 2227/108 (20130101) A01K 2267/0387 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/873 (20130101) C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251491 | Zharov |
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| FUNDED BY |
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| APPLICANT(S) | BioVentures, LLC (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Pavlovich Zharov (Little Rock, Arkansas) |
| ABSTRACT | A fractionated photoacoustic flow cytometry (PAFC) system and methods for the in vivo detection of target objects in biofluidic systems (e.g., blood, lymph, urine, or cerebrospinal fluid) of a living organism is described. The fractionated system includes a fractionated laser system, a fractionated optical system, a fractionated acoustic system, and combinations thereof. The fractionated laser system includes at least one laser or laser array for pulsing a target object within the circulatory vessel with fractionated focused laser beams. The fractionated optical system separates one or several laser beams into multiple beams in a spatial configuration on the skin above the circulatory vessel of the living organism. The fractionated acoustic system includes multiple focused ultrasound transducers for receiving photoacoustic signals emitted by the target object in response to the fractionated laser beams. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184284 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0095 (20130101) Original (OR) Class A61B 8/4461 (20130101) A61B 8/4477 (20130101) A61B 2560/04 (20130101) A61B 2562/0204 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1056 (20130101) G01N 15/1434 (20130101) G01N 15/1459 (20130101) G01N 15/1463 (20130101) G01N 15/1475 (20130101) G01N 2015/1006 (20130101) G01N 2015/1062 (20130101) G01N 2015/1075 (20130101) G01N 2015/1438 (20130101) G01N 2015/1477 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251514 | Linnes et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Jacqueline C. Linnes (West Lafayette, Indiana); Divya Tankasala (West Lafayette, Indiana); Shubhankar S. Takle (West Lafayette, Indiana); Orlando S. Hoilett (West Lafayette, Indiana); Gabriel P. Ng (West Lafayette, Indiana); Michael S. Smith (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to a novel device for selective collection and condensation of an exhaled breath, and the method of using the novel device. The novel device is portable and capable of collecting and condensing reproducible volumes of exhaled breath under about 10 minutes by using a unique temperature-based algorithm. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/251254 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/082 (20130101) A61B 5/097 (20130101) Original (OR) Class A61B 5/14532 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251539 | Al-Uzri et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); Simplexity Product Development Inc. (Vancouver, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amira Al-Uzri (Portland, Oregon); Dennis Koop (Beaverton, Oregon); Lisa Bleyle (Beaverton, Oregon); Andrew Chitty (West Linn, Oregon); Robert Beauchamp (Sant Cugat des Valles, Spain); Asa Weiss (Portland, Oregon); Ethan Vella (Portland, Oregon); Gerold Firl (Poway, California) |
| ABSTRACT | Apparatuses and methods for dried blood spot (DBS) sample collection are disclosed. A dried blood spot sampling device is configured to deliver blood through a passage to an absorbent disk in the device and control an amount of blood saturating the absorbent disk. The sampling device may include a manually actuatable component adjustable between a first position, in which an outlet of the passage is not in physical contact with the absorbent disk, and a second position, in which the outlet of the passage is in physical contact with the absorbent disk. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188059 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1513 (20130101) A61B 5/15019 (20130101) A61B 5/15113 (20130101) A61B 5/15117 (20130101) A61B 5/15144 (20130101) A61B 5/150022 (20130101) A61B 5/150213 (20130101) A61B 5/150358 (20130101) Original (OR) Class A61B 5/150412 (20130101) A61B 5/150503 (20130101) A61B 5/150832 (20130101) A61B 5/150908 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 3/502715 (20130101) B01L 2200/0678 (20130101) B01L 2300/069 (20130101) B01L 2300/105 (20130101) B01L 2300/0681 (20130101) B01L 2300/0816 (20130101) B01L 2300/0838 (20130101) B01L 2400/0406 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251540 | ANDESHMAND et al. |
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| FUNDED BY |
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| APPLICANT(S) | Talis Biomedical Corporation (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sayeed ANDESHMAND (Dublin, California); Thomas H. CAULEY, III (Redwood City, California); John DIXON (Moss Beach, California); David GLADE (San Ramon, California); Hédia MAAMAR (El Dorado Hills, California); Michael John McADAMS (Los Gatos, California); Dzam-Si Jesse NG (Fremont, California); David Alexander ROLFE (San Francisco, California) |
| ABSTRACT | Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/087479 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/150755 (20130101) A61B 5/150961 (20130101) Original (OR) Class Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251548 | Bose et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Soumya Bose (Corvallis, Oregon); Boyu Shen (Corvallis, Oregon); Matthew Johnston (Corvallis, Oregon) |
| ABSTRACT | A battery-less heartbeat monitoring system that operates continuously using energy harvested from a low-grade heat source or small thermal gradient, such as human body heat and the gradient that exists between skin and the ambient environment in most circumstances. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169136 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/308 (20210101) Original (OR) Class A61B 5/7225 (20130101) A61B 2560/0214 (20130101) A61B 2560/0252 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251552 | DeMazumder et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
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| INVENTOR(S) | Deeptankar DeMazumder (Baltimore, Maryland); Gordon Tomaselli (Lutherville, Maryland) |
| ABSTRACT | In accordance with an aspect of the present invention, a system and method allows for the assessment of health and mortality based on dynamic nonlinear calculations of self-similar fluctuation patterns in a time series of QT intervals and of other physiological signals, such as RR intervals, temperature, blood pressure, respiration, saturation of peripheral oxygen, intracardiac pressures, and electroencephalogram. In order to nonlinearly determine health and mortality, time series of QT intervals and of other physiological signals (e.g., RR intervals) are simultaneously obtained, and entropy values are calculated for each signal over the same temporal interval. “EntropyX” is calculated from relative changes between moments and entropy of QT intervals and those of other physiological signals over seconds to days. The absolute and relative entropy values at a specific time point and/or subsequent changes in entropy over future time points can be used to determine a treatment plan for the subject. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/233208 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/0006 (20130101) A61B 5/316 (20210101) A61B 5/349 (20210101) A61B 5/352 (20210101) A61B 5/364 (20210101) Original (OR) Class A61B 5/369 (20210101) A61B 5/02055 (20130101) A61B 5/6898 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251582 | Bambot et al. |
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| FUNDED BY |
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| APPLICANT(S) | Shabbir Bambot (West Hills, California); Joesph Webster Stayman (Baltimore, Maryland); Andrew Leong (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shabbir Bambot (West Hills, California); Joesph Webster Stayman (Baltimore, Maryland); Andrew Leong (Baltimore, Maryland) |
| ABSTRACT | A method is provided to perform an imaging scan on a target tissue. The imaging scan includes generating a signal directed at a portion of a target tissue using a collimator that includes a slot, wherein a source of a signal assembly is incoherently interrupted. The method also includes receiving at least a portion of the signal from the portion of the target tissue at a linear signal detector positioned directly opposite from the signal assembly with respect to the target tissue, and simultaneously translating the linear signal detector and adjusting a width of the at least one slot of the collimator such that a fan width of the signal at the linear signal detector corresponds to a width of a detector window disposed in the linear signal detector. The method also includes rotating a stage about the target tissue, and repeating performing the imaging scan on the target tissue. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176593 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/06 (20130101) Original (OR) Class A61B 6/032 (20130101) A61B 6/54 (20130101) A61B 6/502 (20130101) A61B 6/4078 (20130101) A61B 6/4452 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251611 | Mitra et al. |
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| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York); Wisconsin Alumni Research Foundation (Vladison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jhimli Mitra (Niskayuna, New York); Sudhanya Chatterjee (Bangalore, India); Thomas Kwok-Fah Foo (Clifton Park, New York); Desmond Teck Beng Yeo (Clifton Park, New York); Bryan Patrick Bednarz (Madison, Wisconsin); Sydney Jupitz (Madison, Wisconsin) |
| ABSTRACT | The present disclosure relates to automatically determining respiratory phases (e.g., end-inspiration/expiration respiratory phases) in real time using ultrasound beamspace data. The respiratory phases may be used subsequently in a therapy or treatment (e.g., image-guided radiation-therapy (IGRT)) for precise dose-delivery. In certain implementations, vessel bifurcation may be tracked and respiration phases determined in real time using the tracked vessel bifurcations to facilitate respiration gating of the treatment or therapy. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 16/795220 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/055 (20130101) A61B 5/7267 (20130101) A61B 6/032 (20130101) A61B 6/469 (20130101) A61B 6/5247 (20130101) A61B 8/13 (20130101) A61B 8/0891 (20130101) A61B 8/5223 (20130101) A61B 8/5261 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4814 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251848 | TRACEY et al. |
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| APPLICANT(S) | The Feinstein Institutes for Medical Research (Manhasset, New York) |
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| INVENTOR(S) | Kevin J. TRACEY (Old Greenwich, Connecticut); Howland Shaw WARREN (Cambridge, Massachusetts); Michael Allen FALTYS (Valencia, California); Carol Ann AMELLA (East Northport, New York); Christopher CZURA (Lake Grove, New York); Jared M. HUSTON (New York, New York) |
| ABSTRACT | Devices, systems and methods for stimulating (e.g., noninvasively) a subject's inflammatory reflex are provided to reduce bleed time. The method may include the step of non-invasively stimulating the inflammatory reflex (e.g., the vagus nerve, the splenic nerve, the hepatic nerve, the facial nerve, and the trigeminal nerve) of a subject, such as by mechanical stimulation, in a manner which significantly reduces bleed time in the subject. Devices for non-invasively stimulating the inflammatory reflex may include a movable tip or actuator that is controlled to mechanically stimulate the ear. The devices may be hand-held or wearable, and may stimulate the cymba conchae region of the subject's ear. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170772 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 23/00 (20130101) A61H 39/04 (20130101) Original (OR) Class A61H 2201/1207 (20130101) A61H 2205/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251897 | O'Halloran et al. |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Thomas V. O'Halloran (Chicago, Illinois); Haimei Chen (Evanston, Illinois); Andrew Mazar (Highland Park, Illinois) |
| ABSTRACT | The present invention relates to nanoparticle encapsulated arsenic and platinum compositions and methods of use thereof. In particular, the present invention provides co-encapsulation of active forms of arsenic and platinum drugs into liposomes, and methods of using such compositions for the diagnosis and treatment of cancer. |
| FILED | Thursday, October 03, 2019 |
| APPL NO | 16/592263 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 9/1271 (20130101) A61K 31/282 (20130101) A61K 33/24 (20130101) A61K 33/36 (20130101) A61K 38/40 (20130101) A61K 38/193 (20130101) A61K 45/06 (20130101) A61K 47/6913 (20170801) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/72 (20130101) C07F 15/0093 (20130101) Peptides C07K 16/2887 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251922 | Koeberl et al. |
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| APPLICANT(S) | Duke University (Durham, North Carolina); National University of Singapore (Singapore, Singapore) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina); National University of Singapore (Singapore, Singapore) |
| INVENTOR(S) | Dwight D. Koeberl (Durham, North Carolina); Paul M. Yen (Singapore, Singapore); Benjamin L. Farah (Rocky River, Ohio) |
| ABSTRACT | The present disclosure is directed to methods of treating a steatosis-associated disorder by administering a therapeutic agent selected from a lysosomal enzyme, an autophagy-inducing agent, or a combination thereof. Steatosis-associated disorders discussed herein include GSD Ia, GSD Ib, GSD Ic, NAFLD, and NASH. Other embodiments are directed to methods of reversing steatosis, modulating autophagy, inducing autophagy, and reversing glycogen storage. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/190018 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/12 (20130101) A61K 31/55 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 31/155 (20130101) A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 31/198 (20130101) A61K 31/216 (20130101) A61K 31/277 (20130101) A61K 31/352 (20130101) A61K 31/355 (20130101) A61K 31/385 (20130101) A61K 31/436 (20130101) A61K 31/522 (20130101) A61K 31/575 (20130101) A61K 31/5415 (20130101) A61K 31/7016 (20130101) A61K 33/00 (20130101) A61K 38/47 (20130101) A61K 38/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Enzymes C12Y 301/04012 (20130101) C12Y 302/0102 (20130101) C12Y 302/01022 (20130101) C12Y 302/01045 (20130101) C12Y 302/01049 (20130101) C12Y 302/01076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210251925 — TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF
| US 20210251925 | DORN, II |
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| FUNDED BY |
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| APPLICANT(S) | MITOCHONDRIA EMOTION, INC. (Hamilton, Ohio) |
| ASSIGNEE(S) | MITOCHONDRIA EMOTION, INC. (Hamilton, Ohio) |
| INVENTOR(S) | Gerald W. DORN, II (Hamilton, Ohio) |
| ABSTRACT | Compounds and compositions including stereoisomers of 6-phenylhexanamide derivative small molecule mitofusin activators are described. In particular, mitofusin activators comprising derivatives of (trans-4-hydroxycyclohexyl)-6-phenylhexanamide, which are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin-1 (MFN1) and/or mitofusin-2 (MFN2), or mitochondrial dysfunction, are described. Methods of treatment and pharmaceutical formulations are also described. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245388 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/165 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251928 | GALAZYUK |
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| FUNDED BY |
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| APPLICANT(S) | Northeast Ohio Medical University (Rootstown, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander V. GALAZYUK (Kent, Ohio) |
| ABSTRACT | A method of treating tinnitus in a subject is described that includes administering a therapeutically effective amount of a group II metabotropic glutamate receptor (mGluR) agonist to the subject. A method of screening a subject having tinnitus for treatment with a group II mGluR agonist that includes testing the use of residual inhibition to suppress tinnitus in the subject, wherein suppression of tinnitus by residual inhibition indicates that a group II mGluR agonist would be effective for treating tinnitus in the subject, is also described. |
| FILED | Friday, February 19, 2016 |
| APPL NO | 15/999753 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/196 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251958 | Ausubel et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); RHODE ISLAND HOSPITAL, A LIFESPAN-PARTNER (Providence, Rhode Island); EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederick M. Ausubel (Newton, Massachusetts); Wooseong Kim (Providence, Rhode Island); Eleftherios Mylonakis (Providence, Rhode Island); William M. Wuest (Atlanta, Georgia) |
| ABSTRACT | The present application provides compounds of formula: Methods of using these compounds for killing bacterial growth and treating bacterial infections are also provided. |
| FILED | Wednesday, April 10, 2019 |
| APPL NO | 17/046463 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) A61K 31/404 (20130101) Original (OR) Class A61K 31/4439 (20130101) A61K 31/7036 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 209/36 (20130101) C07D 209/42 (20130101) C07D 401/06 (20130101) C07D 403/04 (20130101) C07D 405/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251959 | Fu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Fu (Baltimore, Maryland); Justin Hanes (Baltimore, Maryland); Donald Jeffrey Zack (Baltimore, Maryland); Zhiyong Yang (San Diego, California); Derek Stuart Welsbie (Lutherville, Maryland); Cynthia Ann Berlinicke (Baltimore, Maryland) |
| ABSTRACT | Methods for increasing the encapsulation or incorporation of Sunitinib into polymeric matrices have been developed. The resulting formulations provide for more sustained controlled release of sunitinib or other inhibitors of JNK signaling, which bind to DLK. Increased loading is achieved using an alkaline solvent system. The pharmaceutical compositions can be administered to treat or reduce neuronal death due to elevated intraocular pressure. Upon administration, the sunitinib or other inhibitor is released over an extended period of time at concentrations which are high enough to produce therapeutic benefit, but low enough to avoid unacceptable levels of cytotoxicity, and which provide much longer release than inhibitor without conjugate. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228423 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 9/0051 (20130101) A61K 9/1647 (20130101) A61K 9/5153 (20130101) A61K 9/5192 (20130101) A61K 31/404 (20130101) Original (OR) Class A61K 31/506 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251960 | Marnett et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Lawrence J. Marnett (Nashville, Tennessee); Andy J. Liedtke (Nashville, Tennessee); Trevor M. Penning (Springfield, Pennsylvania); Adegoke O. Adeniji (Drexel Hill, Pennsylvania); Michael C. Byrns (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236694 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Original (OR) Class A61K 31/405 (20130101) Heterocyclic Compounds C07D 209/08 (20130101) C07D 209/26 (20130101) C07D 209/70 (20130101) C07D 231/56 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251969 | Abdallah et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut); The Unied States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chadi Abdallah (Fairfield, Connecticut); John Krystal (Woodbridge, Connecticut); Ronald Duman (Guilford, Connecticut); Gerard Sanacora (Guilford, Connecticut) |
| ABSTRACT | The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269470 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0053 (20130101) A61K 31/135 (20130101) A61K 31/436 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/24 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251987 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Rugang Zhang (Elkins Park, Pennsylvania); Sergey Karakashev (Philadelphia, Pennsylvania) |
| ABSTRACT | In some embodiments, therapeutic treatments for a disease such as a cancer arc disclosed, including pharmaceutical compositions and methods of using pharmaceutical compositions for treating the cancer wherein the cancer cells overexpress arginine methyltransferase CARM1. In some embodiments, the therapeutic treatments disclosed include methods comprising the step of administering a therapeutically effective dose of an enhancer of zeste homolog 2 (EZH2) inhibitor to a subject, including a human subject, wherein the cancer cells of the subject overexpress arginine methyltransferase CARM1. In some embodiments, the EZH2 inhibitors are administered in conjunction with platinum-based antineoplastic drugs. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240594 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/444 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 33/24 (20130101) A61K 33/243 (20190101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 405/12 (20130101) C07D 471/04 (20130101) C07D 473/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252003 | Margulies et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan S. Margulies (Villanova, Pennsylvania); Tamas Dolinay (Wynnewood, Pennsylvania) |
| ABSTRACT | Disclosed herein are methods of preventing and/or treating lung injury and/or lung inflammation in a subject comprising administering to the subject a therapeutically effective dose of a PERK pathway inhibitor. Pharmaceutical compositions for the prevention and/or treatment of lung injury and/or lung inflammation comprising PERK pathway inhibitors are also provided. Also disclosed are uses of a PERK inhibitor in the manufacture of a medicament for the prevention and/or treatment of a lung injury and/or inflammation. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313154 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252016 | SLAGA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, the University of Texas System (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas J. SLAGA (San Antonio, Texas); Jacob JUNCO (San Antonio, Texas); Huiyun LIANG (San Antonio, Texas); Sara REYNA (San Antonio, Texas) |
| ABSTRACT | Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol. |
| FILED | Saturday, April 17, 2021 |
| APPL NO | 17/233457 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/05 (20130101) A61K 31/19 (20130101) A61K 31/56 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252026 | Poddar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ranjana Poddar (Albuquerque, New Mexico); Surojit Paul (Albuquerque, New Mexico); UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ranjana Poddar (Albuquerque, New Mexico); Surojit Paul (Albuquerque, New Mexico) |
| ABSTRACT | A method for treating a hyperhomocysteinemic subject having cerebral ischemic stroke generally includes administering to the hyperhomocysteinemic subject, following cerebral stroke, a composition that includes an inhibitor or an antagonist of a GluN2A-containing N-methyl-D-aspartate receptor (NMDAR) in an amount effective to ameliorate at least one symptom or clinical sign of cerebral stroke. |
| FILED | Monday, July 08, 2019 |
| APPL NO | 16/973825 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/415 (20130101) A61K 31/497 (20130101) A61K 31/675 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252033 | PAINTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George R. PAINTER (Atlanta, Georgia); Gregory R. BLUEMLING (Decatur, Georgia); Michael C. NATCHUS (Alpharetta, Georgia); Shuli MAO (Marietta, Georgia); Jose MARENGO (Atlanta, Georgia); Michael W. HAGER (Kennesaw, Georgia); David PERRYMAN (Decatur, Georgia) |
| ABSTRACT | This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of human coronavirus 2019-nCoV. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170172 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/008 (20130101) A61K 9/0075 (20130101) A61K 9/0078 (20130101) A61K 31/34 (20130101) A61K 31/52 (20130101) A61K 31/341 (20130101) A61K 31/403 (20130101) A61K 31/404 (20130101) A61K 31/496 (20130101) A61K 31/513 (20130101) A61K 31/522 (20130101) A61K 31/536 (20130101) A61K 31/665 (20130101) A61K 31/675 (20130101) A61K 31/4178 (20130101) A61K 31/4406 (20130101) A61K 31/4965 (20130101) A61K 31/7068 (20130101) Original (OR) Class A61K 31/7076 (20130101) A61K 45/06 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 11/005 (20130101) A61M 11/007 (20140204) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/06 (20130101) C07H 19/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252034 | Hirano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michio Hirano (New York, New York); Caterina Garone (Cambridge, United Kingdom) |
| ABSTRACT | The invention relates generally to a pharmacological therapy for a human genetic diseases, specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxyribonucleoside monophosphate, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine monophosphate (dTMP) or deoxycytidine monophosphate (dCMP), or mixtures thereof. This molecular bypass approach is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242862 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/708 (20130101) A61K 31/7068 (20130101) A61K 31/7072 (20130101) Original (OR) Class A61K 31/7076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252040 | ALVERDY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois); RUSH UNIVERSITY MEDICAL CENTER (Chicago, Illinois) |
| ASSIGNEE(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois); RUSH UNIVERSITY MEDICAL CENTER (Chicago, Illinois) |
| INVENTOR(S) | John C. ALVERDY (Glenview, Illinois); Olga Y. ZABORINA (Brookfield, Illinois); Richard A. JACOBSON (Chicago, Illinois) |
| ABSTRACT | Disclosed herein is the de novo synthesis of phosphorylated polyethylene glycol compounds with three defined ABA (hydrophilic/-phobic/-philic) structures: ABA-PEG10k-Pi10, ABA-PEG16k-Pi14, and ABA-PEG20k-Pi20 and linear polymer PEG20k-Pi20 absent of hydrophobic block. The disclosure also provides materials and methods for treating or reducing the risk or likelihood of developing, anastomotic leak or other microbe-mediated disorders by administering a therapeutically effective amount of a plasminogen inhibitor such as tranexamic acid and/or a phosphate-loaded polymer. |
| FILED | Tuesday, April 23, 2019 |
| APPL NO | 17/049793 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/80 (20130101) Original (OR) Class A61K 31/196 (20130101) A61K 31/197 (20130101) A61K 38/57 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 41/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252057 | CHAPUIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aude CHAPUIS (Seattle, Washington); Paul NGHIEM (Redmond, Washington); Megan MCAFEE (Seattle, Washington); Natalie MILLER (Seattle, Washington); Kelly PAULSON (Shoreline, Washington); David KOELLE (Seattle, Washington); Thomas SCHMITT (Seattle, Washington); Candice CHURCH (Seattle, Washington) |
| ABSTRACT | The present disclosure provides binding proteins and TCRs with high affinity and specificity against Merkel cell polyomavirus T antigen epitopes or peptides, T cells expressing such high affinity Merkel cell polyomavirus T antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating Merkel cell carcinoma. |
| FILED | Wednesday, May 15, 2019 |
| APPL NO | 17/055969 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/215 (20130101) A61K 38/2013 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) C12N 2501/2302 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252058 | GOTTSCHALK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (Memphis, Tennessee); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (Memphis, Tennessee); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| INVENTOR(S) | Stephen GOTTSCHALK (Memphis, Tennessee); Brooke PRINZING (Memphis, Tennessee); Giedre KRENCIUTE (Memphis, Tennessee) |
| ABSTRACT | The application relates to a chimeric antigen receptor that targets Eph receptors and allows activation of co-stimulatory pathways. The application also relates to polynucleotides that encode the chimeric antigen receptor, vectors, and host cells comprising the chimeric antigen receptor. The application also relates to methods for preparing host cells comprising a chimeric antigen receptor in order to improve the in vivo effector function of the chimeric antigen receptor host cells. |
| FILED | Friday, May 17, 2019 |
| APPL NO | 17/056181 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70575 (20130101) C07K 14/70578 (20130101) C07K 14/70596 (20130101) C07K 16/2866 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252068 | Yang, Ph.D. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Otto O. Yang, Ph.D. (Los Angeles, California); Balamurugan Arumugam (Los Angeles, California) |
| ABSTRACT | Disclosed herein are fusion fragment chimeric antigen receptors (FF-CARs), engineered cells expressing FF-CARs, and methods of using thereof to treat, reduce, or inhibit infections by enveloped viruses in subjects. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 17/252228 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 35/28 (20130101) Peptides C07K 14/15 (20130101) C07K 14/7051 (20130101) C07K 14/70517 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252070 | Thon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Platelet Biogenesis, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan N. Thon (Watertown, Massachusetts); Brad Dykstra (Watertown, Massachusetts); Brenden William Smith (Watertown, Massachusetts) |
| ABSTRACT | Methods for producing megakaryocytes and platelets derived from inducible pluripotent stem cells and comprising a therapeutic agent are provided. The present disclosure further provides methods and compositions for loading a platelet or a megakaryocyte with a therapeutic agent and for genetically modifying a platelet or a megakaryocyte to express an agent. |
| FILED | Saturday, June 29, 2019 |
| APPL NO | 16/973688 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 35/19 (20130101) Original (OR) Class A61K 47/6901 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0644 (20130101) C12N 5/0696 (20130101) C12N 2501/26 (20130101) C12N 2501/91 (20130101) C12N 2501/115 (20130101) C12N 2501/125 (20130101) C12N 2501/145 (20130101) C12N 2501/155 (20130101) C12N 2501/165 (20130101) C12N 2501/415 (20130101) C12N 2501/2303 (20130101) C12N 2501/2306 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252108 | Butler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); U.S. DEPARTMENT OF VETERANS' AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Alistair Butler (St. Louis, Missouri); Susan Farr (St. Louis, Missouri); Clemence Girardet (Paris, France) |
| ABSTRACT | Disclosed are methods and compositions for treating cognitive decline in subjects in need. More specifically, disclosed are methods of administrating exogenous adropin to subjects suffering from, or at risk of, cognitive decline. Also disclosed are subjects who would benefit from such treatment and pharmaceutical acceptable compositions comprising adropin, adropin34-76, and derivatives or variations thereof. |
| FILED | Tuesday, June 04, 2019 |
| APPL NO | 17/054740 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/22 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252110 | STOFFERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (PHILADELPHIA, Pennsylvania); The Children's Hospital of Philadelphia (PHILADELPHIA, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (PHILADELPHIA, Pennsylvania); The Children's Hospital of Philadelphia (PHILADELPHIA, Pennsylvania) |
| INVENTOR(S) | Doris STOFFERS (Moorestown, New Jersey); Diva D. DE LEON (Penn Valley, Pennsylvania); Charles STANLEY (Drexel Hill, Pennsylvania) |
| ABSTRACT | This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/105484 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252114 | Khalili et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kamel Khalili (Bala Cynwyd, Pennsylvania); Wenhui Hu (Cherry Hill, New Jersey) |
| ABSTRACT | A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring. |
| FILED | Tuesday, October 13, 2020 |
| APPL NO | 17/068999 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 35/12 (20130101) A61K 38/465 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2320/30 (20130101) C12N 2740/16063 (20130101) Enzymes C12Y 301/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252115 | Mohler et al. |
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| FUNDED BY |
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| APPLICANT(S) | Health Research, Inc. (Buffalo, New York); University of Kentucky Research Foundation (Lexington, Kentucky); University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James L. Mohler (Buffalo, New York); Michael Fiandalo (Buffalo, New York); David Watt (Lexington, Kentucky); Elizabeth Wilson (Chapel Hill, North Carolina) |
| ABSTRACT | A method of inhibiting activity or expression of one or more 3α-oxidoreductase enzymes that share a common catalytic site and convert androstanediol to DHT. The method comprises introducing one or more agents into cells that comprise the one or more 3α-oxidoreductase enzymes, wherein said one or more agents: i) inhibit function of one or more of said enzymes; ii) inhibit translation of mRNA encoding said enzymes; iii) disrupt or delete genes encoding said enzymes; or a combination thereof. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/239196 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/7088 (20130101) A61K 38/465 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2310/12 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252130 | Watanabe et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shinji Watanabe (Tokyo, Japan); Tokiko Watanabe (Tokyo, Japan); Yoshihiro Kawaoka (Middleton, Wisconsin) |
| ABSTRACT | The invention provides a vaccine comprising an effective amount of an isolated recombinant influenza virus comprising a mutant M gene segment that is mutated so that upon viral replication the mutant M gene expresses a functional M1 protein and a mutant M2 protein with a deletion of the cytoplasmic tail and either lacking a transmembrane domain or having a mutated transmembrane domain. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229001 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/543 (20130101) A61K 2039/5254 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252137 | Mannie |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | East Carolina University (Greenville, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark D. Mannie (Greenville, North Carolina) |
| ABSTRACT | The present invention provides methods of modulating an immunological disorder or an immune response. The methods include administering to a subject or a cell an effective amount of an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier. Compositions including an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier are also provided. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/161772 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 33/06 (20130101) A61K 38/19 (20130101) A61K 38/215 (20130101) A61K 39/0008 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 2039/577 (20130101) A61K 2039/55505 (20130101) A61K 2039/55511 (20130101) A61K 2039/55522 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252146 | Cao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENERON PHARMACEUTICALS, INC. (TARRYTOWN, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuan Cao (White Plains, New York); Dingjiang Liu (Pleasantville, New York); Long Xu (Shanghai, China PRC) |
| ABSTRACT | The present disclosure provides stable pharmaceutical formulations comprising a human antibody that specifically binds to Ebola Virus (EBOV). In certain embodiments, the formulations contain, in addition to an anti-EBOV antibody, a buffer, an amino acid, a non-ionic surfactant, and a stabilizer. The pharmaceutical formulations of the present disclosure exhibit a substantial degree of antibody stability upon stress, for example, agitation during transport, and storage, for example, storage at temperatures greater than 40° C. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/155432 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 39/39591 (20130101) Original (OR) Class A61K 47/22 (20130101) A61K 47/26 (20130101) Peptides C07K 16/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252150 | Crowe, Jr. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. Crowe, Jr. (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to antibodies binding previously undefined epitopes on influenza A virus hemagglutinin and methods for use thereof. |
| FILED | Thursday, August 22, 2019 |
| APPL NO | 17/270115 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252191 | LAURENCIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CONNECTICUT (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cato T. LAURENCIN (Avon, Connecticut); Lakshmi S. NAIR (Avon, Connecticut); Maumita BHATTACHARJEE (Farmington, Connecticut) |
| ABSTRACT | Compositions including a decellularized and enzymatically solubilized amnionic membrane (AM) hydrogel, methods for making such compositions, and methods for their use are disclosed. |
| FILED | Tuesday, June 11, 2019 |
| APPL NO | 16/973198 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/3604 (20130101) Original (OR) Class A61L 27/3687 (20130101) A61L 27/3691 (20130101) A61L 27/3695 (20130101) A61L 27/3834 (20130101) A61L 2400/06 (20130101) A61L 2430/06 (20130101) A61L 2430/16 (20130101) A61L 2430/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252263 | Masri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radi Masri (Ellicott City, Maryland); Didier Depireux (Ellicott City, Maryland) |
| ABSTRACT | The present invention provides a method of treating a condition affecting a tooth or periodontium in a subject, comprising administering to the subject's tooth or periodontium a composition comprising biocompatible magnetic, magnetizable, or magnetically responsive agents; and applying an external magnetic field, wherein the magnetic, magnetizable, or magnetically responsive agents migrate to a desired location in response to the externally applied magnetic field, thereby treating a condition affecting the tooth or periodontium in the subject. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/174055 |
| CURRENT CPC | Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 5/50 (20170201) A61C 19/06 (20130101) A61C 19/08 (20130101) A61C 19/063 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0063 (20130101) A61K 9/5094 (20130101) A61K 31/155 (20130101) A61K 41/00 (20130101) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 19/00 (20130101) A61M 37/00 (20130101) Original (OR) Class A61M 2037/0007 (20130101) A61M 2210/0637 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) A61N 2/06 (20130101) A61N 2/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252308 | Jin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| INVENTOR(S) | Jian-Yue Jin (Indianapolis, Indiana); Wenhu Pi (Indianapolis, Indiana); Feng-Ming Kong (Indianapolis, Indiana); Weili Wang (Indianapolis, Indiana) |
| ABSTRACT | Methods for directly measuring a patient's relative sensitivity to radiation therapy are provided. In particular, the methods provide for calculating a radiation sensitivity quotient for monocytes in culture. The methods can be incorporated into radiotherapy (RT) treatment planning systems, which are also provided. The methods can be used to optimize patient treatment plans, thereby developing patient-specific radiation treatment plans. Methods for treating a patient with radiotherapy with an optimized treatment plan are provided. |
| FILED | Monday, June 10, 2019 |
| APPL NO | 16/973738 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1031 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5047 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252313 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen XU (Ann Arbor, Michigan); Clifford Suhyun CHO (Ann Arbor, Michigan) |
| ABSTRACT | Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161498 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252493 | Goodson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Boyd M. Goodson (Carbondale, Illinois); Eduard Y. Chekmenev (Troy, Michigan); Igor V. Koptyug (Novosibirsk, Russian Federation); Kirill V. Kovtunov (Novosibirsk, Russian Federation); Roman V. Shchepin (Nashville, Tennessee); Bryce E. Kidd (Carbondale, Illinois); Jonathan Gesiorski (Hickory Hills, Illinois); Max E. Gemeinhardt (Carbondale, Illinois); Danila A. Barskiy (Berkeley, California) |
| ABSTRACT | The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described. |
| FILED | Monday, February 17, 2020 |
| APPL NO | 16/792637 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1616 (20130101) B01J 31/2273 (20130101) B01J 31/2295 (20130101) B01J 31/4038 (20130101) Original (OR) Class B01J 38/02 (20130101) B01J 38/68 (20130101) B01J 2531/827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252510 | Schaffer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | In one aspect of the invention, the fluidic device includes a fluidic chip includes a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269349 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253420 | Tung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Steve Tung (Fayetteville, Arkansas); Bo Ma (Fayetteville, Arkansas); Ty Seiwert (Fayetteville, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steve Tung (Fayetteville, Arkansas); Bo Ma (Fayetteville, Arkansas); Ty Seiwert (Fayetteville, Arkansas) |
| ABSTRACT | A method of fabricating a sensing device for DNA sequencing and biomolecule characterization including the steps of fabricating a microelectrode chip having a silicon substrate and a silicon nitride diaphragm, attaching a monolayer graphene sheet to the silicon nitride diaphragm, dicing a portion of the monolayer graphene sheet to form a graphene microribbon, converting the graphene microribbon to a graphene nanoribbon, and converting the graphene nanoribbon to a carbyne. A sensing device for DNA sequencing and biomolecule characterization is also disclosed. The sensing device includes a silicon substrate, a cavity in the silicon substrate covered by a silicon nitride layer, microelectrodes attached to the silicon nitride layer, graphene covering the microelectrodes, and carbyne attached to a portion of the silicon nitride layer covering said cavity. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/173839 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/02 (20130101) B32B 7/12 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00071 (20130101) Original (OR) Class B81C 3/001 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253519 | GE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Ying GE (Madison, Wisconsin); Song JIN (Madison, Wisconsin); Tania GUARDADO ALVAREZ (Madison, Wisconsin); Kyle BROWN (Madison, Wisconsin) |
| ABSTRACT | The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-trans-modifications. In addition, the present photo-cleavable anionic surfactants are also suitable for dissolving polypeptides in bottom-up proteomic experiments including extracellular matrix proteomics, and are suitable as a substitute for SDS in gel electrophoresis. |
| FILED | Tuesday, June 04, 2019 |
| APPL NO | 16/972881 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 309/15 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253524 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lan Huang (Irvine, California); Scott D. Rychnovsky (Irvine, California) |
| ABSTRACT | Synthesis of a sulfoxide-containing homobifunctional cysteine-reactive mass spectrometry-cleavable cross-linker for mapping intra-protein interactions in a protein and inter-protein interactions in a protein complex is provided. Methods for mapping intra-protein interactions in a protein and inter-protein interactions in a protein complex and cross-linking mass spectrometry for identifying one or more cross-linked peptides using the cross-linker are provided. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 16/870431 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/452 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) G01N 33/6848 (20130101) G01N 2560/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253558 | Mazitschek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ralph Mazitschek (Belmont, Massachusetts); Sofia A. Santos (Saugus, Massachusetts); Mark A. Tye (San Ramon, California); N. Connor Payne (Cambridge, Massachusetts); Dyann F. Wirth (Boston, Massachusetts) |
| ABSTRACT | The present application provides compounds which are inhibitors of aminoacyl tRNA-synthetase (e.g., prolyl-tRNA-synthetase) and are useful for treating disorders associated with aminoacyl tRNA-synthetase activity and/or expression. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also provided. |
| FILED | Monday, June 10, 2019 |
| APPL NO | 16/973080 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) Heterocyclic Compounds C07D 241/28 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) Original (OR) Class C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253561 | THAKUR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts); Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ganeshingh A. THAKUR (Cambridge, Massachusetts); Diomedes E. LOGOTHETIS (Brookline, Massachusetts); Lucas CANTWELL (Plymouth, Massachusetts); Yu XU (Malden, Massachusetts); Anantha SHEKAR (Indianapolis, Indiana) |
| ABSTRACT | Selective small molecule regulators of GIRK potassium channels are provided, which are effective in treatment of post-traumatic stress disorder and other medical conditions. |
| FILED | Tuesday, June 11, 2019 |
| APPL NO | 17/053458 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/22 (20180101) Heterocyclic Compounds C07D 231/40 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 409/12 (20130101) Original (OR) Class C07D 413/12 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253588 | Mekonnen et al. |
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| FUNDED BY |
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| APPLICANT(S) | AGENEBIO, INC. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Belew Mekonnen (Gilbertsville, Pennsylvania); John A. Butera (Clarksburg, New Jersey); Jianxing Huang (Bethlehem, Pennsylvania) |
| ABSTRACT | This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those benzodiazepine derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of a α5-containing GABAA receptor agonist (e.g., a α5-C containing GABAA receptor positive allosteric modulator) as described herein in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI (aMCI), Age-Associated Memory Impairment (AAMI), Age Related Cognitive Decline (ARCD), dementia, Alzheimer's Disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis (ALS), cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease (PD), autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction. It also relates to the use of a α5-containing GABAA receptor agonist (e.g., a α5-containing GABAA receptor positive allosteric modulator) as described herein in treating brain cancers (including brain tumors, e.g., medulloblastomas), and cognitive impairment associated therewith. |
| FILED | Wednesday, December 20, 2017 |
| APPL NO | 16/471237 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 487/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253625 | KAZAKOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RealSeq Biosciences, Inc. (Santa Cruz, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergei A. KAZAKOV (San Jose, California); Sergio BARBERAN-SOLER (Santa Cruz, California); Anne DALLAS (Santa Cruz, California); Brian H. JOHNSTON (Scotts Valley, California) |
| ABSTRACT | Disclosed herein are methods and compositions for the detection of small RNAs in a sample. The methods and compositions disclosed herein may be used for preparing sequencing libraries of the small RNAs, fragments of RNAs and DNAs. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/199968 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) C07H 21/02 (20130101) Original (OR) Class C07H 21/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6855 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253627 | NITZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DFH THERAPEUTICS (Gaithersburg, Maryland); The United States of American as represented by the Secretary,Department of Health and Human Service (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore J. NITZ (Boyds, Maryland); Carl T. WILD (Gaithersburg, Maryland); David E. MARTIN (Shawnee, Oklahoma); Eric O. FREED (Frederick, Maryland) |
| ABSTRACT | The present invention concerns novel pharmaceutically active triterpene amine derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the triterpene amine compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C-28 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus-1 (HIV-1). |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/254189 |
| CURRENT CPC | Steroids C07J 63/008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253639 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. Wang (Ann Arbor, Michigan); Jing Chen (Ann Arbor, Michigan) |
| ABSTRACT | The disclosure is directed to heterodimeric peptide reagents that specifically bind epidermal growth factor receptor (EGFR) and epidermal receptor growth factor 2 (ErbB2), as well as methods for detecting, targeting, diagnosing and/or treating diseases of the esophagus, including esophageal carcinoma, esophageal adenocarcinoma (EAC), high grade dysplasia (HGD) of the esophagus, and Barrett's neoplasia in a patient using the heterodimeric peptide reagents. |
| FILED | Thursday, May 16, 2019 |
| APPL NO | 17/054900 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0056 (20130101) Peptides C07K 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253644 | Srivastava et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Arun Srivastava (Gainesville, Florida); Li Zhong (Boxborough, Massachusetts); Sergei Zolotukhin (Gainesville, Florida); George Vladimirovich Aslanidi (Austin, Minnesota); Mavis Agbandje-McKenna (Gainesville, Florida); Kim M. Van Vliet (Gainesville, Florida); Chen Ling (Gainesville, Florida) |
| ABSTRACT | Disclosed are next-generation multi-mutated capside protein-modified rAAV expression vector, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using these high transduction efficiency vector constructs in a variety of therapeutic applications including, inter alia, as delivery agents for the treatment or amelioration of one or more diseases or abnormal conditions in an affected mammal using in vivo and/or ex situ viral vector-based gene therapy protocols. Also disclosed are large-scale production methods for the multi-mutated, capsid-modified rAAV expression vector, viral particles, and infectious virions, as well as use of the disclosed compositions in the manufacture of medicaments for use in a variety of in vitro and/or in vivo therapeutic methodologies. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/132607 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 48/005 (20130101) A61K 48/0008 (20130101) A61K 48/0091 (20130101) A61K 2039/5158 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/8645 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) C12N 2750/14171 (20130101) C12N 2810/6027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253655 | MILLAY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPT, OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| INVENTOR(S) | Douglas MILLAY (Park Hills, Kentucky); Dilani GAMAGE (Cincinnati, Ohio); Leonid CHERNOMORDIK (North Potomac, Maryland); Evgenia LEIKINA (Derwood, Maryland) |
| ABSTRACT | Some embodiments of the invention include polypeptides comprising a myomerger polypeptide or an extracellular myomerger polypeptide. Other embodiments of the invention include nucleic acid molecules encoding polypeptides comprising a myomerger polypeptide or an extracellular myomerger polypeptide. Other embodiments of the invention include vectors comprising the nucleic acid molecule. Yet other embodiments of the invention include methods of using a myomerger polypeptide or an extracellular myomerger polypeptide. Additional embodiments of the invention are also discussed herein. |
| FILED | Friday, June 14, 2019 |
| APPL NO | 17/251019 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4716 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253656 | Schlom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Schlom (Potomac, Maryland); Kwong-Yok Tsang (Bethesda, Maryland) |
| ABSTRACT | The invention provides a human cytotoxic T lymphocyte (CTL) agonist epitope from the C-terminal subunit of mucin 1 (MUC1-C), which can be used as a peptide, polypeptide (protein), and/or in vaccine or other composition for the prevention or therapy of cancer. The invention further provides a nucleic acid encoding the peptide, protein, or polypeptide, a vector comprising the nucleic acid, a cell comprising the peptide, polypeptide, nucleic acid, or vector, and compositions thereof. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240260 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 38/00 (20130101) A61K 38/20 (20130101) A61K 38/22 (20130101) A61K 38/191 (20130101) A61K 38/193 (20130101) A61K 38/195 (20130101) A61K 38/217 (20130101) A61K 39/39 (20130101) A61K 39/00117 (20180801) A61K 45/06 (20130101) Peptides C07K 14/82 (20130101) C07K 14/4727 (20130101) Original (OR) Class C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253683 | Seder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland); Sanaria Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland); Sanaria Inc. (Rockville, Maryland) |
| INVENTOR(S) | Robert Seder (Chevy Chase, Maryland); Neville Kisalu (Bethesda, Maryland); Azza Idris (Bethesda, Maryland); Barbara Flynn (Bethesda, Maryland); Stephen Hoffman (Rockville, Maryland) |
| ABSTRACT | Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/243455 |
| CURRENT CPC | Peptides C07K 16/205 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253705 | BELPERIO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | John A. BELPERIO (Los Angeles, California) |
| ABSTRACT | A method is described for treating or preventing organ injury, delayed type hypersensitivity, graft-versus-host disease or allograft rejection, for example in the lung, kidney, heart, liver in a subject by administering to the subject an effective amount of a CCR4 inhibitor or antagonist. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/177890 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/2818 (20130101) Original (OR) Class C07K 16/2866 (20130101) C07K 16/4291 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253731 | ROBSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Antagen Institute for Biomedical Research (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon C. ROBSON (Weston, Massachusetts); Yan Wu SHANG (North Reading, Massachusetts); Wenda GAO (Sharon, Massachusetts); Haohai ZHANG (Brighton, Massachusetts); Paola DE ANDRADE MELLO (Cambridge, Massachusetts) |
| ABSTRACT | In combination with conventional therapies (e.g., targeted therapy, chemotherapy, and angiogenesis inhibitors etc.), immunotherapies targeting checkpoint molecules have shown promise in the treatment of solid or liquid tumors. However, apoptotic regulatory T cells (Treg) induced by such therapies often become more suppressive in the tumor microenvironment (TME), through increased generation of adenosine tightly controlled by ectonucleotidases, viz. CD39 and CD73. CD39/ENTPD1, a novel checkpoint molecule, is highly expressed and activated on the tumor vasculature and infiltrating immune cells, promoting tumor growth. Deletion or blockade of CD39 enhances anti-tumor activity by augmenting anti-tumor immune responses and inhibiting tumor angiogenesis. The present invention is based at least in part on the development of anti-CD39 antibodies which mediate CD39 downregulation on immune cells, such as T-cells with markers of T-cell exhaustion, and the demonstrated utility of these antibodies in blocking tumor growth with minimal side effects in pre-clinical models. |
| FILED | Friday, June 14, 2019 |
| APPL NO | 17/251507 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/2896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253734 | LU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IMCARE BIOTECH, LLC (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanyong LU (Horsham, Pennsylvania); Felix LU (Woodland Hills, California) |
| ABSTRACT | Anti-AS-SPIK antibodies are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to diagnose disorders characterized by the expression of AS-SPIK (e.g., liver cancer). Diagnostic methods and kits comprising the anti-AS-SPIK antibodies are also disclosed. |
| FILED | Wednesday, March 06, 2019 |
| APPL NO | 16/978634 |
| CURRENT CPC | Peptides C07K 16/38 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/32 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/567 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 33/57438 (20130101) G01N 2800/50 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253738 | Granade et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| INVENTOR(S) | Timothy Clyde Granade (Conyers, Georgia); Ae Saekhou Youngpairoj (Snellville, Georgia); William Marshall Switzer (Decatur, Georgia); Walid M. Heneine (Atlanta, Georgia); Chou-Pong Pau (Atlanta, Georgia); HaoQiang Zheng (Johns Creek, Georgia); Jan Pohl (Tucker, Georgia) |
| ABSTRACT | Disclosed are monoclonal antibodies that specifically bind emtricitabine (FTC). Methods are also disclosed for using these antibodies to detect FTC in samples. In some embodiments, these methods are of use for determining if a subject is complying with a therapeutic or prophylactic protocol. In other embodiments, methods are disclosed for determining the dose of FTC to administer to a subject. |
| FILED | Wednesday, July 10, 2019 |
| APPL NO | 17/255763 |
| CURRENT CPC | Peptides C07K 16/44 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253987 | Engler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Engler (San Diego, California); Afsheen Banisadr (La Jolla, California); Pranjali Beri (La Jolla, California); Alexander Fuhrmann (La Jolla, California) |
| ABSTRACT | The present disclosure provides a device for assessing adhesion strength of a cancer cell and methods of using the same. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180492 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 25/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0679 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253997 | Wilson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wilson Wolf Manufacturing Corporation (New Brighton, Minnesota) |
| ASSIGNEE(S) | Wilson Wolf Manufacturing Corporation (New Brighton, Minnesota) |
| INVENTOR(S) | John R. Wilson (New Brighton, Minnesota) |
| ABSTRACT | This invention relates to methods and devices that improve cell culture efficiency. They include the use of gas permeable culture compartments that reduce the use of space while maintaining uniform culture conditions, and are more suitable for automated liquid handling. They include the integration of gas permeable materials into the traditional multiple shelf format to resolve the problem of non-uniform culture conditions. They include culture devices that use surfaces comprised of gas permeable, plasma charged silicone and can integrate traditional attachment surfaces, such as those comprised of traditional tissue culture treated polystyrene. They include culture devices that integrate gas permeable, liquid permeable membranes. A variety of benefits accrue, including more optimal culture conditions during scale up and more efficient use of inventory space, incubator space, and disposal space. Furthermore, labor and contamination risk are reduced. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/164977 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254016 | HAWKINS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (BOSTON, Massachusetts); THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (AUSTIN, Texas) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (BOSTON, Massachusetts); THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (AUSTIN, Texas) |
| INVENTOR(S) | Finn Joseph HAWKINS (Boston, Massachusetts); Darrell N. KOTTON (Newton, Massachusetts); Shingo SUZUKI (Austin, Texas); Brian R. DAVIS (Austin, Texas); Cristina BARILLÀ (Houston, Texas) |
| ABSTRACT | Described herein is a method of generating in-vitro differentiated airway basal cells and compositions thereof. Also described herein is a method of treating a pulmonary disease comprising administering the in-vitro differentiated airway basal cells and compositions thereof. In another aspect, described herein is a disease model comprising patient-derived or genetically modified in-vitro differentiated airway basal cells and compositions thereof. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/42 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 11/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0689 (20130101) Original (OR) Class C12N 2500/90 (20130101) C12N 2501/15 (20130101) C12N 2501/39 (20130101) C12N 2501/115 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/405 (20130101) C12N 2501/415 (20130101) C12N 2501/999 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254043 | SCHARENBERG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SEATTLE CHILDREN'S HOSPITAL (dba SEATTLE CHILDREN'S RESEARCH INSTITUTE) (Seattle, Washington) |
| ASSIGNEE(S) | SEATTLE CHILDREN'S HOSPITAL (dba SEATTLE CHILDREN'S RESEARCH INSTITUTE) (Seattle, Washington) |
| INVENTOR(S) | Andrew M. SCHARENBERG (Seattle, Washington); Michael T. CERTO (Seattle, Washington); Kamila Sabina GWIAZDA (Seattle, Washington) |
| ABSTRACT | The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244180 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) A61K 38/45 (20130101) A61K 38/52 (20130101) A61K 38/465 (20130101) A61K 2035/124 (20130101) Peptides C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/90 (20130101) C12N 9/1252 (20130101) C12N 15/62 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2800/80 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254130 | Quake et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Quake (Stanford, California); Thomas M. Snyder (Palo Alto, California); Hannah Valantine (Stanford, California) |
| ABSTRACT | The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/235575 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6837 (20130101) C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254131 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Jehyuk Lee (Allston, Massachusetts); Daniel Levner (Boston, Massachusetts); Michael Super (Lexington, Massachusetts) |
| ABSTRACT | Methods of making a three-dimensional matrix of nucleic acids within a cell is provided. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238682 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254137 | MA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bing MA (Clarksville, Maryland); Rose VISCARDI (Timonium, Maryland); Jacques RAVEL (Laurel, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| INVENTOR(S) | Bing MA (Clarksville, Maryland); Rose VISCARDI (Timonium, Maryland); Jacques RAVEL (Laurel, Maryland) |
| ABSTRACT | A correlative finding between increased Clostridiales and/or Bifidobacteriales bacterial abundance in the gut and intestinal barrier maturation of preterm neonates at-risk for development of necrotizing enterocolitis (NEC) is disclosed. These findings form the basis for the methods of identifying preterm infants at risk for developing necrotizing enterocolitis (NEC), the methods of treating such infants, as well as the methods of characterizing intestinal permeability in preterm infants disclosed herein. |
| FILED | Wednesday, May 22, 2019 |
| APPL NO | 17/056562 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254143 | SIMS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Peter A. SIMS (Ardsley, New York); Sayantan BOSE (Collegeville, Pennsylvania); Jinzhou YUAN (Edgewater, New Jersey) |
| ABSTRACT | Described herein are devices, systems, and methods for trapping single-cell lysates in sealed, microwells capable of printing RNA on glass or capturing RNA on beads. These provide efficient, inexpensive manipulation of RNA from individual cells suitable for single-cell transcriptomics on a large scale. Also described are dual barcode capture beads and merged barcode capture beads. |
| FILED | Tuesday, November 27, 2018 |
| APPL NO | 16/766928 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6834 (20130101) Original (OR) Class C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254145 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chao-ting Wu (Brookline, Massachusetts); Son Nguyen (West Roxbury, Massachusetts) |
| ABSTRACT | The present invention relates to a method of covalently attaching a chromosome within a cell to a matrix including modifying a plurality of nucleotides within the chromosome to include a matrix attachment moiety wherein the chromosome contacts the matrix, and attaching the matrix attachment moiety of the plurality of nucleotides to the matrix, thereby attaching the chromosome to the matrix. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/241157 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6841 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254148 | PATEL |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Abhijit Ajit PATEL (Madison, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhijit Ajit PATEL (Madison, Connecticut) |
| ABSTRACT | Methods and compositions are disclosed for measuring low-abundance DNA variants from a complex mixture of DNA molecules. Embodiments of the methods allow for extremely sensitive detection and can distinguish true variants from sequencer misreads and PCR misincorporations. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/173006 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6853 (20130101) Original (OR) Class C12Q 1/6858 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254152 | Velculescu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor E. Velculescu (Dayton, Maryland); Stephen Cristiano (Baltimore, Maryland); Alessandro Leal (Baltimore, Maryland); Jillian A. Phallen (Baltimore, Maryland); Jacob Fiksel (Baltimore, Maryland); Vilmos Adleff (Baltimore, Maryland); Robert B. Scharpf (Baltimore, Maryland) |
| ABSTRACT | This document relates to methods and materials for assessed, monitored, and/or treated mammals (e.g., humans) having cancer. For example, methods and materials for identifying a mammal as having cancer (e.g., a localized cancer) are provided. For example, methods and materials for assessing, monitoring, and/or treating a mammal having cancer are provided. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204892 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254153 | Vogelstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Isaac A. Kinde (Beaumont, California) |
| ABSTRACT | The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe- Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ≥95% of them contain the identical mutation. We illustrate the utility of this approach for determining the fidelity of a polymerase, the accuracy of oligonucleotides synthesized in vitro, and the prevalence of mutations in the nuclear and mitochondrial genomes of normal cells. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/243184 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2525/179 (20130101) C12Q 2525/191 (20130101) C12Q 2563/179 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254159 | FELDMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Arthur M. FELDMAN (Wynnewood, Pennsylvania) |
| ABSTRACT | Identification of BAG3 (Bcl2-associated anthanogene 3) genetic variants were associated with the prevalence non-ischemic or ischemic dilated cardiomyopathy (DCM) and DCM outcomes in individuals of African ancestry. |
| FILED | Friday, June 07, 2019 |
| APPL NO | 16/973353 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254162 | Andolina et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Laurie H. Andolina (Durham, North Carolina); John T. Greenamyre (Sewickley, Pennsylvania); Sruti Shiva (Sewickley, Pennsylvania) |
| ABSTRACT | Methods are disclosed for detecting peripheral mitochondrial DNA damage and dysfunction. Methods are also disclosed that utilize blood samples to detect a neurodegenerative disease, such as Parkinson's disease, and determine the efficacy of therapy. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/227186 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2561/113 (20130101) C12Q 2563/173 (20130101) C12Q 2600/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254163 | SANFORD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Jeremy SANFORD (Santa Cruz, California); Timothy STEME-WEILER (Santa Cruz, California) |
| ABSTRACT | Compounds and methods for regulation of exonic splicing enhancers and exonic splicing silencers. Compounds include polynucleotides targeted to aberrant exonic splicing enhancers and exonic splicing silencers. Compounds and methods for the diagnosis of diseases and conditions associated with aberrant exonic splicing enhancers and exonic splicing silencers. Methods for identifying splicing-sensitive disease mutations, and functional RNA elements as targets for amelioration of aberrant pre-mRNA splicing. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238551 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2320/33 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254173 | Guo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy Lan Guo (Morgantown, West Virginia) |
| ABSTRACT | A method of providing a treatment to a patient having non-small cell lung cancer is provided comprising extracting total RNA from a tumor of non-small cell lung cancer of a patient after the surgical resection, generating complementary DNA (cDNA) of the extracted total RNA from the patients tumor, quantifying of mRNA expression of 7 genes of ABCC4 (SEQ ID NO:1), CCL19 (SEQ ID NO:2), SLC39A8 (SEQ ID NO:3), CD27 (SEQ ID NO:4), FUT7 (SEQ ID NO:5), ZNF71 (SEQ ID NO:6), and DAG1 (SEQ ID NO:7), normalizing of the quantification of the 7 genes with the quantification of a control gene UBC (SEQ ID NO:8), and utilizing the normalized 7 gene mRNA expression quantification to determine whether the patient will benefit from receiving adjuvant chemotherapy or not. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 17/251359 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255072 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yongxin Zhao (Sewickley, Pennsylvania); Feifei Fu (Sewickley, Pennsylvania); Aleksandra Klimas (Pittsburgh, Pennsylvania); Aaron Mitchell (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are improved expansion microscopy methods. Also provided herein are kits useful in expansion microscopy. |
| FILED | Friday, June 14, 2019 |
| APPL NO | 17/251855 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 1/36 (20130101) Original (OR) Class G01N 1/286 (20130101) G01N 1/312 (20130101) G01N 2001/302 (20130101) G01N 2001/364 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255107 | BUTTE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pramod BUTTE (Los Angeles, California); Paul LAPCHAK (San Diego, California); David Scott KITTLE (Running Springs, California) |
| ABSTRACT | The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of-ordinary skill in the art in which this invention belongs. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198816 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/0084 (20130101) A61B 5/14556 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0218 (20130101) G01J 3/2889 (20130101) G01J 3/4406 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 21/645 (20130101) G01N 21/6402 (20130101) G01N 21/6408 (20130101) G01N 21/6428 (20130101) G01N 21/6486 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255170 | Engelhardt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John F. Engelhardt (Iowa City, Iowa); Thomas J. Lynch (Iowa City, Iowa); Preston J. Anderson (Iowa City, Iowa); Weam Shahin (Iowa City, Iowa) |
| ABSTRACT | Compositions and methods to modulate Lef-1/TCF/Wnt signaling ex vivo or in vivo, and assays to detect those modulators, are described. |
| FILED | Wednesday, March 13, 2019 |
| APPL NO | 16/980268 |
| CURRENT CPC | Peptides C07K 14/4705 (20130101) C07K 14/4753 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5041 (20130101) G01N 33/5061 (20130101) Original (OR) Class G01N 33/5073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255174 | KALKUM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Markus KALKUM (Azusa, California); Karine BAGRAMYAN (North Hollywood, California) |
| ABSTRACT | Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin. This assay is designed to capture a low number of toxin molecules and to measure their intrinsic protease activity via conversion of a fluorogenic or luminescent substrate. Also provided herein are novel peptides that can be specifically cleaved by BoNT and novel peptides that are resistant to cleavage by BoNT. The combination of these cleavable and control peptides can be used for implementation of an exemplary ALISSA used to specifically detect BoNT enzymatic activity. Furthermore, the ALISSA as described herein may also be used in a column based format for use in a high-throughput system for testing large quantities of samples. |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/020658 |
| CURRENT CPC | Peptides C07K 7/08 (20130101) C07K 14/705 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/569 (20130101) G01N 33/573 (20130101) G01N 33/5306 (20130101) G01N 33/5308 (20130101) Original (OR) Class G01N 2333/32 (20130101) G01N 2333/33 (20130101) G01N 2333/38 (20130101) G01N 2333/90241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255186 | Panchapakesan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts); University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Balaji Panchapakesan (Worcester, Massachusetts); Farhad Khosravi (Worcester, Massachusetts); Shesh N. Rai (Louisville, Kentucky) |
| ABSTRACT | The present disclosure provides micro-array devices for capturing cells in blood and methods of their use. In some aspects, a method for counting cells in a blood sample is provided, the method comprising applying a blood sample onto a CNT device; allowing cells in the blood sample to differentially settle on the CNT device, and identifying and counting cells of preselected type in the blood sample. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231533 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 15/1056 (20130101) G01N 27/125 (20130101) G01N 27/127 (20130101) G01N 33/574 (20130101) Original (OR) Class G01N 33/5748 (20130101) G01N 33/57415 (20130101) G01N 33/57492 (20130101) G01N 2015/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255193 | CRAVATT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin F. CRAVATT (La Jolla, California); Stephan M. HACKER (San Diego, California); Keriann M. BACKUS (La Jolla, California) |
| ABSTRACT | Disclosed herein are methods and compounds for profiling a lysine reactive protein. Also described herein are methods, compounds, and compositions for identifying a small molecule fragment ligand that interacts with a reactive lysine residue. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139697 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/641 (20130101) C12N 9/1007 (20130101) C12N 9/6472 (20130101) Enzymes C12Y 101/01042 (20130101) C12Y 201/01023 (20130101) C12Y 304/22061 (20130101) C12Y 304/22063 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/582 (20130101) G01N 33/5008 (20130101) G01N 33/6812 (20130101) Original (OR) Class G01N 33/6842 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255195 | Schaaf et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneaplis, Minnesota); Fluorescence Innovations, Inc. (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tory M. Schaaf (Minneapolis, Minnesota); David D. Thomas (Minneapolis, Minnesota); Benjamin Grant (Minneapolis, Minnesota); Kurt C. Peterson (Saint Paul, Minnesota); Gregory D. Gillispie (Falcon Heights, Minnesota) |
| ABSTRACT | Provided herein are methods for identifying a compound that alters fluorescence resonance energy transfer (FRET) of a protein. In one embodiment, the method includes providing a target protein, where the target protein includes two heterologous domains, each domain having chromophores that together act as a FRET pair. In another embodiment, the method includes providing a target protein and a second protein, wherein the target protein includes a first heterologous domain including a chromophore, and the second protein includes a second heterologous domain including a chromophore, where the chromophores together act as a FRET pair. The method further includes contacting a sample including the target protein and optional second protein with a test compound to form a mixture, and measuring a fluorescence emission spectrum of the mixture during exposure to a light source. The fluorescence emission spectrum is decomposed into at least two component spectra, where in one embodiment the component spectra include a donor chromophore emission and an acceptor chromophore emission. A ratio (R) is then calculated, and in one embodiment, R is determined according to |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/151519 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/52 (20130101) G01N 33/542 (20130101) G01N 33/582 (20130101) G01N 33/6845 (20130101) Original (OR) Class G01N 2500/04 (20130101) G01N 2500/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255198 | Niculescu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS OFFICE OF GENERAL (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America as Represented by the Department of Veterans Affairs Office (Washington, District of Columbia) |
| INVENTOR(S) | Alexander Bogdan Niculescu (Indianapolis, Indiana) |
| ABSTRACT | Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for stress disorders. Also disclosed are new methods of use for drugs and natural compounds repurposed for use in reducing stress severity, as well as for preventing and treating stress disorders. All the above mentioned methods are computer assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. A universal approach in everybody, as well as a personalized approaches by gender, and by diagnosis, are disclosed. |
| FILED | Wednesday, June 05, 2019 |
| APPL NO | 16/973687 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/7004 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255201 | Bateman |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randall Bateman (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides methods for blood-based examination useful to identify subjects with Aβ amyloidosis and/or to identify subjects who should or should not undergo further testing or treatment for Aβ amyloidosis, as well as methods for treating subjects diagnosed with Aβ amyloidosis by the methods disclosed herein. |
| FILED | Tuesday, May 01, 2018 |
| APPL NO | 16/610428 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2333/4709 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255204 | O'Bryant et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of North Texas Health Science Center at Fort Worth (Fort Worth, Texas); Board of Regents,The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sid E. O'Bryant (Aledo, Texas); Robert C. Barber (Benbrook, Texas); Guanghua Xiao (Coppell, Texas); Dwight German (Dallas, Texas) |
| ABSTRACT | The present invention includes methods and kits for measuring a level of four or more biomarkers selected measuring a level of four or more biomarkers selected from ILL IL7, TNFα, IL5, IL6, CRP, IL10, TNC, ICAM1, FVII, I309, TNFR1, A2M, TARC, adiponectin, MIP1, eotaxin3, sVCAM1, TPO, FABP, IL18, B2M, SAA, PPY, DJ1, and α-synuclein, Aβ40, Aβ42, tau, α-synuclein, and NfL in a sample separated from a human subject in the primary care setting with neurological disease with a nucleic acid, an immunoassay or an enzymatic activity assay. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/131990 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/2821 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256691 | Sepehrband et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Farshid Sepehrband (Los Angeles, California); Jeiran Choupan (Los Angeles, California) |
| ABSTRACT | Systems and methods for mapping brain perivascular spaces. A system may include a memory to store one or more images of a brain of a patient. The system may further include a processor coupled to the memory. The processor may be configured to obtain a first and a second image of the brain. The processor may be further configured to combine the first image and the second image to preserve and magnify structures including the brain perivascular spaces within the image of the brain. The processor may be further configured to determine the brain perivascular spaces within the combined image of the brain of the patient. The processor may be further configured to generate a three-dimensional (3-D) map of the perivascular spaces. The system may further include a display configured to display the perivascular spaces to an operator. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176725 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/5608 (20130101) G01R 33/56341 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10028 (20130101) G06T 2207/10092 (20130101) G06T 2207/20024 (20130101) G06T 2207/20084 (20130101) G06T 2207/20221 (20130101) G06T 2207/30016 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256692 | Popescu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel Popescu (Champaign, Illinois); Mikhail Eugene Kandel (Champaign, Illinois); Yuchen He (Urbana, Illinois); Nahil A. Sobh (Urbana, Illinois); Matthew Benjamin Wheeler (Tolono, Illinois); Marcello Rubessa (Middleton, Wisconsin) |
| ABSTRACT | A system generates a context mask based on quantitative image data. The system obtains the quantitative image data which was captured via a quantitative imaging of a sample. The quantitative image data is compared to previous quantitative image data through application of the quantitative image data to a neural network trained using the previous quantitative image data and corresponding constructed context masks. The comparison generates the context mask for the quantitative image data. The context mask provides context for the quantitative parameter values that facilities characterization of the sample. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178486 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/10072 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257044 | Califano et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Califano (New York, New York); Mariano Javier Alvarez (Cortlandt Manor, New York) |
| ABSTRACT | Techniques to profile a disease or a disorder (e.g., a tumor) based on a protein activity signature are disclosed herein. An example method can include measuring quantitatively protein activity of a plurality of master regulator proteins in a sample from a disease or disorder; and profiling the tumor from the quantitative protein activity of the master regulator proteins. Also disclosed are methods of identifying a compound or compounds that treats diseases or disorders (e.g., inhibit tumor cell growth). |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/020715 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/57484 (20130101) G01N 2500/20 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257202 | EBERLIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Livia Schiavinato EBERLIN (Austin, Texas); Thomas MILNER (Austin, Texas); Jialing ZHANG (Austin, Texas); John LIN (Austin, Texas); John RECTOR (Austin, Texas); Nitesh KATTA (Austin, Texas); Aydin ZAHEDIVASH (Austin, Texas) |
| ABSTRACT | Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis. |
| FILED | Monday, November 30, 2020 |
| APPL NO | 17/106445 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0045 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/0293 (20130101) B01L 3/502 (20130101) B01L 2200/0605 (20130101) B01L 2400/0655 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/02 (20130101) G01N 30/72 (20130101) G01N 33/487 (20130101) G01N 33/574 (20130101) G01N 33/6848 (20130101) G01N 2560/00 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/04 (20130101) H01J 49/0031 (20130101) H01J 49/0431 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210251540 | ANDESHMAND et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Talis Biomedical Corporation (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sayeed ANDESHMAND (Dublin, California); Thomas H. CAULEY, III (Redwood City, California); John DIXON (Moss Beach, California); David GLADE (San Ramon, California); Hédia MAAMAR (El Dorado Hills, California); Michael John McADAMS (Los Gatos, California); Dzam-Si Jesse NG (Fremont, California); David Alexander ROLFE (San Francisco, California) |
| ABSTRACT | Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/087479 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/150755 (20130101) A61B 5/150961 (20130101) Original (OR) Class Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251558 | Gilchrist et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Triangle Institute (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristin Hedgepath Gilchrist (Rockville, Maryland); Sonia Grego (Durham, North Carolina); Gregory Frederick Lewis (Bloomington, Indiana); Meghan Sarah Hegarty-Craver (Durham, North Carolina) |
| ABSTRACT | A computer implemented method is disclosed for detecting a mild traumatic brain injury (mTBI) on a subject having recently suffered a head injury. The method includes (1) receiving first electrocardiogram (ECG) data from the subject during a first transition from a first position to a second position; and (2) determining a probability value of mTBI within the subject based at least partially on the first ECG data during the first transition. The first position may be a prone position or a supine position and the second position may be a standing position. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236266 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/002 (20130101) A61B 5/0006 (20130101) A61B 5/0205 (20130101) A61B 5/352 (20210101) A61B 5/1124 (20130101) A61B 5/02416 (20130101) A61B 5/4064 (20130101) Original (OR) Class A61B 5/4884 (20130101) A61B 5/7275 (20130101) A61B 2503/10 (20130101) A61B 2562/0219 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251848 | TRACEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Feinstein Institutes for Medical Research (Manhasset, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin J. TRACEY (Old Greenwich, Connecticut); Howland Shaw WARREN (Cambridge, Massachusetts); Michael Allen FALTYS (Valencia, California); Carol Ann AMELLA (East Northport, New York); Christopher CZURA (Lake Grove, New York); Jared M. HUSTON (New York, New York) |
| ABSTRACT | Devices, systems and methods for stimulating (e.g., noninvasively) a subject's inflammatory reflex are provided to reduce bleed time. The method may include the step of non-invasively stimulating the inflammatory reflex (e.g., the vagus nerve, the splenic nerve, the hepatic nerve, the facial nerve, and the trigeminal nerve) of a subject, such as by mechanical stimulation, in a manner which significantly reduces bleed time in the subject. Devices for non-invasively stimulating the inflammatory reflex may include a movable tip or actuator that is controlled to mechanically stimulate the ear. The devices may be hand-held or wearable, and may stimulate the cymba conchae region of the subject's ear. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170772 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 23/00 (20130101) A61H 39/04 (20130101) Original (OR) Class A61H 2201/1207 (20130101) A61H 2205/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251860 | Krishna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vijay Krishna (Cleveland Heights, Ohio); Sanjay Anand (Cleveland, Ohio); Edward Maytin (Cleveland, Ohio); Stephen Grobmyer (Cleveland, Ohio) |
| ABSTRACT | Sunscreen compositions comprising a dermatologically acceptable carrier and a polyhydroxy fullerene compound are described. The sunscreen compositions can be used to protect a substrate such as the skin of a subject from the effects of ultraviolet radiation. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/182093 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/11 (20130101) A61K 8/19 (20130101) Original (OR) Class A61K 8/44 (20130101) A61K 2800/56 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252033 | PAINTER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George R. PAINTER (Atlanta, Georgia); Gregory R. BLUEMLING (Decatur, Georgia); Michael C. NATCHUS (Alpharetta, Georgia); Shuli MAO (Marietta, Georgia); Jose MARENGO (Atlanta, Georgia); Michael W. HAGER (Kennesaw, Georgia); David PERRYMAN (Decatur, Georgia) |
| ABSTRACT | This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of human coronavirus 2019-nCoV. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170172 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/008 (20130101) A61K 9/0075 (20130101) A61K 9/0078 (20130101) A61K 31/34 (20130101) A61K 31/52 (20130101) A61K 31/341 (20130101) A61K 31/403 (20130101) A61K 31/404 (20130101) A61K 31/496 (20130101) A61K 31/513 (20130101) A61K 31/522 (20130101) A61K 31/536 (20130101) A61K 31/665 (20130101) A61K 31/675 (20130101) A61K 31/4178 (20130101) A61K 31/4406 (20130101) A61K 31/4965 (20130101) A61K 31/7068 (20130101) Original (OR) Class A61K 31/7076 (20130101) A61K 45/06 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 11/005 (20130101) A61M 11/007 (20140204) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/06 (20130101) C07H 19/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252115 | Mohler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Health Research, Inc. (Buffalo, New York); University of Kentucky Research Foundation (Lexington, Kentucky); University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James L. Mohler (Buffalo, New York); Michael Fiandalo (Buffalo, New York); David Watt (Lexington, Kentucky); Elizabeth Wilson (Chapel Hill, North Carolina) |
| ABSTRACT | A method of inhibiting activity or expression of one or more 3α-oxidoreductase enzymes that share a common catalytic site and convert androstanediol to DHT. The method comprises introducing one or more agents into cells that comprise the one or more 3α-oxidoreductase enzymes, wherein said one or more agents: i) inhibit function of one or more of said enzymes; ii) inhibit translation of mRNA encoding said enzymes; iii) disrupt or delete genes encoding said enzymes; or a combination thereof. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/239196 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/7088 (20130101) A61K 38/465 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2310/12 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252133 | BERTHOLET GIRARDIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| ASSIGNEE(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| INVENTOR(S) | Sylvie BERTHOLET GIRARDIN (Rockville, Maryland); Arun KUMAR (Siena, Italy) |
| ABSTRACT | The present invention is in the field of treating and/or preventing viral infections. In particular, the present invention relates to immunogenic or pharmaceutical compositions comprising self-replicating RNA molecules that encode influenza virus antigens for treating and/or preventing influenza infections. |
| FILED | Friday, August 16, 2019 |
| APPL NO | 17/268647 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252188 | Kang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyun-Wook Kang (Winston-Salem, North Carolina); Sang Jin Lee (Winston-Salem, North Carolina); Anthony Atala (Winston-Salem, North Carolina); James J. Yoo (Winston-Salem, North Carolina) |
| ABSTRACT | A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237116 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) Original (OR) Class A61L 27/26 (20130101) A61L 27/38 (20130101) A61L 27/52 (20130101) A61L 27/222 (20130101) A61L 27/225 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) B29C 64/124 (20170801) B29C 64/393 (20170801) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252190 | Francis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Embody, Inc. (Norfolk, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. Francis (Norfolk, Virginia); Stella Petrova (Blacksburg, Virginia); Nicholas Thayer (Morrisville, North Carolina) |
| ABSTRACT | A method for producing a bundle of biopolymer fibers. Biopolymer is dissolved in acid in a closed container made of materials inert to the acid and to the collagen to form a biopolymer solution. The solution is stirred, then centrifuged to degas it. The degassed solution is put into syringes on a holder. The number of syringes equals the number of fibers in the bundle. The syringes are mounted in a rotatable holder. Essentially equal quantities of degassed solution are extruded from the syringes to produce fibers, which are gathered and fed into a formation buffer bath. The fibers are kept taught after extrusion and dehydrated in a dehydrating solution in a dehydrating bath. The fibers are wound a collector to collect the bundle. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/239013 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 17/14 (20130101) A61L 17/105 (20130101) A61L 27/24 (20130101) Original (OR) Class A61L 27/386 (20130101) A61L 27/3804 (20130101) A61L 2430/10 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/02 (20130101) D01D 5/06 (20130101) D01D 5/38 (20130101) D01D 7/00 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252246 | Reeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lynntech, Inc. (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Reeh (College Station, Texas); Mahesh Waje (College Station, Texas); Mehmet Kesmez (College Station, Texas); Carlos Salinas (Bryan, Texas); Jibi Varughese (College Station, Texas); John Zbranek (College Station, Texas); Seth Cocking (College Station, Texas); Ashwin Balasubramanian (College Station, Texas); Cory Teurman (College Station, Texas); James Netherland (Bryan, Texas); Geoffrey Duncan Hitchens (Allen, Texas) |
| ABSTRACT | The present invention includes a device for hypoxia training including a breathable gas source; a mask in fluid communication with the breathable gas source; a mask-state detector that uses one or more criteria to determine if the mask is being worn by a subject, wherein the mask-state detector is capable of communicating an indication of a mask-off state or a mask-on state; a flowmeter in fluid communication with the mask and coupled to the mask-state detector; and a pressure regulator in fluid communication with the mask and with the breathable gas source, and coupled to the mask-state detector, wherein the pressure regulator sets a first pressure at the mask when the mask-state detector communicates an indication of a mask-off state or a second pressure at the mask when the mask-state detector communicates an indication of a mask-on state. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/232701 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/10 (20130101) Original (OR) Class A61M 16/12 (20130101) A61M 16/22 (20130101) A61M 16/0045 (20130101) A61M 16/101 (20140204) A61M 16/106 (20140204) A61M 16/202 (20140204) A61M 16/209 (20140204) A61M 16/1085 (20140204) A61M 2016/1025 (20130101) A61M 2202/0208 (20130101) Devices, Apparatus or Methods for Life-saving A62B 7/14 (20130101) Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 23/18 (20130101) A63B 2220/56 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 9/085 (20130101) G09B 9/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252480 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | University of Utah Research Foundation (, None) |
| INVENTOR(S) | Hanseup Kim (Salt Lake City, Utah); Hao-Chieh Hsieh (Salt Lake City, Utah) |
| ABSTRACT | A gas chromatography system can include a circulatory loop, a gas inlet positioned along the circulatory loop, a gas outlet positioned along the circulatory loop, a micro column positioned in line with the circulatory loop, and an in-line population sensor positioned in line with the circulatory loop. The in-line population sensor can be configured to detect changes in gas population. The gas inlet and gas outlet can be associated with a gas inlet valve and gas outlet valve, and configured to admit or withdraw gas from the circulatory loop, respectively. A gas sample can be circulated through the circulatory loop for at least one cycle, and a component of the gas sample can be detected using the in-line population sensor. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308822 |
| CURRENT CPC | Separation B01D 53/025 (20130101) B01D 2253/202 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/285 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/44 (20130101) G01N 30/461 (20130101) G01N 30/6095 (20130101) G01N 2030/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252493 | Goodson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Boyd M. Goodson (Carbondale, Illinois); Eduard Y. Chekmenev (Troy, Michigan); Igor V. Koptyug (Novosibirsk, Russian Federation); Kirill V. Kovtunov (Novosibirsk, Russian Federation); Roman V. Shchepin (Nashville, Tennessee); Bryce E. Kidd (Carbondale, Illinois); Jonathan Gesiorski (Hickory Hills, Illinois); Max E. Gemeinhardt (Carbondale, Illinois); Danila A. Barskiy (Berkeley, California) |
| ABSTRACT | The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described. |
| FILED | Monday, February 17, 2020 |
| APPL NO | 16/792637 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1616 (20130101) B01J 31/2273 (20130101) B01J 31/2295 (20130101) B01J 31/4038 (20130101) Original (OR) Class B01J 38/02 (20130101) B01J 38/68 (20130101) B01J 2531/827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252510 | Schaffer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | In one aspect of the invention, the fluidic device includes a fluidic chip includes a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269349 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252932 | MORGAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRATT and MILLER ENGINEERING AND FABRICATION, INC. (NEW HUDSON, Michigan) |
| ASSIGNEE(S) | PRATT and MILLER ENGINEERING AND FABRICATION, INC. (NEW HUDSON, Michigan) |
| INVENTOR(S) | CHRISTOPHER M. MORGAN (ANN ARBOR, Michigan); JOHN EDWARD USTICK (BLOOMFIELD HILLS, Michigan); GUIDO FRANCESCO RITELLI (FARMINGTON HILLS, Michigan) |
| ABSTRACT | A ground plane detection system for a motor vehicle and a motor vehicle with enhanced maneuverability characteristics of a type including a frame structure, a pair of front road engaging wheels, a pair of rear road engaging wheels. The detection system includes, a body controller configured for determining a ground plane including receiving at least one of a GPS signal and an inertial navigation system signal. The body controller is further configured for providing a roll and a pitch signal with respect to the ground plane; and the body controller combining the signals with inputs from one or more sensors detecting displacement of the front and rear road engaging wheels. The body controller is also configured to determine a terrain plane reference to the ground plane, and providing control signals to cause the vehicle to undertake an earth level orientation mode or a terrain following orientation mode. |
| FILED | Friday, April 19, 2019 |
| APPL NO | 17/048971 |
| CURRENT CPC | Vehicle Suspension Arrangements B60G 7/001 (20130101) B60G 17/0165 (20130101) Original (OR) Class B60G 2400/82 (20130101) B60G 2400/0511 (20130101) B60G 2400/0512 (20130101) B60G 2401/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253482 | Garcia et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northrop Grumman Systems Corporation. (Falls Church, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin W.C. Garcia (Tremonton, Utah); David R. Nelson (Logan, Utah) |
| ABSTRACT | A preceramic resin formulation comprising a polycarbosilane preceramic polymer, an organically modified silicon dioxide preceramic polymer, and, optionally, at least one filler. The preceramic resin formulation is formulated to exhibit a viscosity of from about 1,000 cP at about 25° C. to about 5,000 cP at a temperature of about 25° C. The at least one filler comprises first particles having an average mean diameter of less than about 1.0 μm and second particles having an average mean diameter of from about 1.5 μm to about 5 μm. Impregnated fibers comprising the preceramic resin formulation are also disclosed, as is a composite material comprising a reaction product of the polycarbosilane preceramic polymer, organically modified silicon dioxide preceramic polymer, and the at least one filler. Methods of forming a ceramic matrix composite are also disclosed. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/096694 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 1/00 (20130101) B64C 1/12 (20130101) B64C 1/066 (20130101) B64C 3/26 (20130101) B64C 11/20 (20130101) Cosmonautics; Vehicles or Equipment Therefor B64G 1/58 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/80 (20130101) C04B 35/82 (20130101) C04B 35/515 (20130101) C04B 35/571 (20130101) Original (OR) Class C04B 35/62863 (20130101) C04B 35/62868 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/282 (20130101) Jet-propulsion Plants F02K 9/08 (20130101) F02K 9/346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253577 | Bhattacharjee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BIOVERSYS AG (Basel, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashoke Bhattacharjee (Cheshire, Connecticut); Erin M. Duffy (Deep River, Connecticut); Trudy Grossman (New Haven, Connecticut); Joseph A. Ippolito (Guilford, Connecticut); Zoltan F. Kanyo (North Haven, Connecticut) |
| ABSTRACT | The present disclosure relates to methods of treating, preventing, reducing the risk of, or delaying the onset of microbial infections in humans and animals that are caused by or involves one or more microorganisms which are capable of being used as biological weapons, the method including administering a pyrrolocytosine compound or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer. |
| FILED | Thursday, June 06, 2019 |
| APPL NO | 16/972775 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253605 | Jacobs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Anacor Pharmaceuticals, Inc. (New York, New York); The Government of the United States, as represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Toms Jacobs (Wake Forest, North Carolina); Yang Liu (Foster City, California); Richard J. Sciotti (Olney, Maryland); Jason D. Speake (Durham, North Carolina); Gavin Alistair Whitlock (Canterbury, United Kingdom); Paul Alan Glossop (Canterbury, United Kingdom); Charles Eric Mowbray (Nyon, Switzerland); Delphine Françoise Monique Launay (Ornex, France); Stephen John Robinson (Geneva, Switzerland) |
| ABSTRACT | This application describes compounds, compositions, and methods which are useful in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/173884 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253811 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng Jiang (Gainesville, Florida); Sin-Yen Leo (Hillsboro, Oregon); Calen Leverant (Gainesville, Florida); Danielle Liu (Nashville, Tennessee); Yin Fang (Gainesville, Florida) |
| ABSTRACT | Described herein are methods and compositions relating to tunable nanoporous coatings. In certain aspects, described herein are methods and compositions wherein a tunable nanoporous coating comprises a tunable nanoporous membrane which transitions from opaque to transparent upon the application of force, and from transparent to opaque after washing with a solvent. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230160 |
| CURRENT CPC | Separation B01D 69/125 (20130101) B01D 71/40 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 22/1006 (20200201) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) Original (OR) Class C08J 7/02 (20130101) Optical Elements, Systems, or Apparatus G02B 1/111 (20130101) G02B 5/0247 (20130101) G02B 5/0268 (20130101) G02B 5/0294 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253875 | KISAILUS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | David KISAILUS (Riverside, California); Ramya MOHAN (Riverside, California) |
| ABSTRACT | A multimodal coating and method of coating a substrate are disclosed. The coating includes a structural framework: and a medium embedded in the structural framework forming an intumescent coating, the intumescent coating configured to undergo intumescent expansion of an outermost coating of the medium upon heating. |
| FILED | Wednesday, July 10, 2019 |
| APPL NO | 17/259475 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/00 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/002 (20130101) C09D 5/185 (20130101) Original (OR) Class C09D 7/61 (20180101) C09D 7/63 (20180101) C09D 105/00 (20130101) C09D 129/04 (20130101) C09D 133/20 (20130101) C09D 161/06 (20130101) C09D 197/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253990 | Glaven et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia); THE CHARLES STARK DRAPER LABORATORY, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | Sarah Glaven (Washington, District of Columbia); Elizabeth Onderko (Alexandria, Virginia); Andrew Maygar (Arlington, Virginia); Matthew Yates (Centreville, Massachusetts) |
| ABSTRACT | Described herein are biofilm bioreactors for synthesis at the interface between two liquids, and methods of using such bioreactors for the biotransformation of feedstocks into chemical products. Also contemplated is the extraction of such products. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178488 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/12 (20130101) C12M 23/24 (20130101) C12M 23/44 (20130101) Original (OR) Class C12M 23/58 (20130101) C12M 25/10 (20130101) C12M 29/16 (20130101) C12M 41/28 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254046 | Hutchison et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Codex DNA, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clyde A. Hutchison (La Jolla, California); Ray-Yuan Chuang (Rockville, Maryland); Vladimir N. Noskov (Gaithersburg, Maryland); Bogumil J. Karas (London, Canada); Kim S. Wise (San Diego, California); Hamilton O. Smith (San Diego, California); John I. Glass (San Diego, California); Chuck Merryman (Encinitas, California); Daniel G. Gibson (Carlsbad, California); J. Craig Venter (La Jolla, California); Krishna Kannan (San Diego, California); Lin Ding (San Diego, California) |
| ABSTRACT | Methods for generating synthetic genomes, for example synthetic genomes having desired properties or viable genomes of reduced size, are disclosed. Also disclosed are synthetic genomes produced by the methods disclosed herein and synthetic cells containing the synthetic genomes disclosed herein. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200633 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/74 (20130101) C12N 15/81 (20130101) C12N 15/1027 (20130101) Original (OR) Class C12N 15/1058 (20130101) C12N 15/1079 (20130101) C12N 15/1093 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254127 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Vikram Pattanayak (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide strategies, methods, and reagents for determining nuclease target site preferences and specificity of site-specific endonucleases. Some methods provided herein utilize a novel “one-cut” strategy for screening a library of concatemers comprising repeat units of candidate nuclease target sites and constant insert regions to identify library members that can been cut by a nuclease of interest via sequencing of an intact target site adjacent and identical to a cut target site. Some aspects of this disclosure provide strategies, methods, and reagents for selecting a site-specific endonuclease based on determining its target site preferences and specificity. Methods and reagents for determining target site preference and specificity are also provided. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/160329 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) Original (OR) Class C12Q 1/6816 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254139 | Dedent et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Talis Biomedical Corporation (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea C. Dedent (San Francisco, California); Matthew B. Lee (San Jose, California); Hedia Maamar (San Jose, California) |
| ABSTRACT | Disclosed herein are methods and compositions for detecting amplicon generated using loop-mediated amplification (LAMP). In particular, the invention relates to compositions comprising molecular beacons and/or LAMP primers and methods for generating and detecting LAMP amplicons. In particular, molecular beacons that bind to novel regions of a LAMP amplicon, and methods of using these probes, are provided. |
| FILED | Monday, November 13, 2017 |
| APPL NO | 16/349190 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6813 (20130101) Original (OR) Class C12Q 1/6816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254469 | Senile et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell Glenn Senile (Oxford, Ohio); Matthew Mark Weaver (Loveland, Ohio); Alexander Martin Sener (Cincinnati, Ohio) |
| ABSTRACT | Airfoil assemblies for gas turbine engines are provided. For example, an airfoil assembly comprises an airfoil, an inner band defining an inner opening shaped complementary to an inner end of the airfoil, and an outer band defining an outer opening shaped complementary to an outer end of the airfoil. The airfoil inner end is received with the inner opening, and the airfoil outer end is received within the outer opening. A strut extends radially through an airfoil cavity. A first pad is defined at a first radial location within the cavity. A second pad is defined within the cavity at a second, different radial location. In some embodiments, the airfoil assembly inner band includes a first inner flange, through which the inner band is secured to a support structure, and the outer band includes a first outer flange, through which the outer band is secured to a support structure. |
| FILED | Tuesday, February 09, 2021 |
| APPL NO | 17/170988 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/142 (20130101) Original (OR) Class F01D 5/147 (20130101) F01D 5/284 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/305 (20130101) F05D 2240/306 (20130101) F05D 2250/711 (20130101) F05D 2250/712 (20130101) F05D 2300/6033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254504 | Spangler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon W. Spangler (Vernon, Connecticut); Douglas M. Berczik (Manchester, Connecticut) |
| ABSTRACT | A method for forming a gas turbine engine component comprises the steps of forming a first portion from a high temperature alloy material, and forming a second portion from the high temperature alloy material, the first and second portions each defining an external surface and an internal surface. At least one heat transfer feature is formed directly on the internal surface of at least one of the first and second portions. The first and second portions are attached together to form a component. A component for a gas turbine engine is also disclosed. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/101712 |
| CURRENT CPC | Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/04 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/147 (20130101) F01D 5/186 (20130101) F01D 9/04 (20130101) F01D 9/041 (20130101) F01D 9/065 (20130101) F01D 11/10 (20130101) F01D 25/005 (20130101) F01D 25/12 (20130101) Original (OR) Class F01D 25/28 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2230/60 (20130101) F05D 2230/236 (20130101) F05D 2260/202 (20130101) F05D 2260/221 (20130101) F05D 2300/131 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254977 | Tarleton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Norman Gerard Tarleton (Glendale, Arizona); Chuck Croker (Glendale, Arizona); Lee K. Strandjord (Tonka Bay, Minnesota) |
| ABSTRACT | In one embodiment, a phase lock loop circuit includes a control circuit, wherein the control circuit is configured to input an estimation having a second frequency and a second phase. The second frequency is selected from a range of frequencies including a first frequency from an acquired signal. A numerically controlled oscillator is coupled to the control circuit, wherein the control circuit is configured to control an output response of the numerically controlled oscillator. The numerically controlled oscillator is configured to receive the estimation from the control circuit and generate an output signal in response to the estimation. A phase detector is coupled to the control circuit and the numerically controlled oscillator, wherein the phase detector is configured to compare the first signal and the output signal and produce a comparison output, the comparison output indicative of a phase difference between the first signal and the estimation. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 16/795365 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/727 (20130101) Original (OR) Class Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/093 (20130101) H03L 7/103 (20130101) H03L 7/0994 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255032 | LAL |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Amit LAL (Ithaca, New York) |
| ABSTRACT | A device configured for low-energy ultrasonic 2D Fourier transform analysis, comprising: (i) a first layer comprising an array of piezoelectric pixels; (ii) a second layer comprising an array of piezoelectric pixels; (iii) a third layer, positioned between the first and second layers, comprising a bulk ultrasonic transmission medium; wherein the second layer of array of piezoelectric pixels is in the Fourier plane of an input signal of the first layer array of piezoelectric pixels. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057868 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 11/08 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/46 (20130101) G01N 2291/0426 (20130101) Electric Digital Data Processing G06F 17/142 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/18 (20130101) H01L 41/083 (20130101) Transmission H04B 11/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255062 | Hackett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan J. Hackett (Newington, Connecticut); Eli C. Warren (Wethersfield, Connecticut); Michael J. Saitta (East Hampton, Connecticut) |
| ABSTRACT | A probe adapter includes an adapter body including a probe aperture and a slot. The probe adapter further includes a driver slidably mounted within the slot and slidable between a first position and a second position. The driver includes a first end and a second end opposite the first end. The first end includes a ramped recess extending in a direction from the first end toward the second end. The probe adapter further includes a threaded fastener configured to contact the second end of the driver so as to retain the driver in the first position. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 16/791730 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 21/003 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/55 (20130101) F05D 2260/31 (20130101) F05D 2260/80 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 15/14 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 1/06705 (20130101) G01R 1/06794 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255071 | Beebe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David J. Beebe (Monona, Wisconsin); Ben P. Casavant (Madison, Wisconsin); David J, Guckenberger (Oconomowoc, Wisconsin); Scott M. Berry (Madison, Wisconsin) |
| ABSTRACT | A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224337 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5088 (20130101) B01L 3/502761 (20130101) B01L 3/502792 (20130101) B01L 2200/0668 (20130101) B01L 2300/045 (20130101) B01L 2300/0803 (20130101) B01L 2300/0816 (20130101) B01L 2400/043 (20130101) B01L 2400/065 (20130101) B01L 2400/0644 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/00 (20130101) B03C 1/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1006 (20130101) C12N 15/1013 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255088 | Jalali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bahram Jalali (Los Angeles, California); Eric D. Diebold (Los Angeles, California); Brandon Buckley (Los Angeles, California) |
| ABSTRACT | An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector. |
| FILED | Monday, October 12, 2020 |
| APPL NO | 17/068573 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) Original (OR) Class G01N 15/1459 (20130101) G01N 15/1484 (20130101) G01N 21/64 (20130101) G01N 33/537 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255159 | Swager et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Timothy Swager (Newton, Massachusetts); Darryl Fong (Boston, Massachusetts); Shaoxiong Luo (Cambridge, Massachusetts); Rafaela Da Silveira Andre (Cambridge, Massachusetts) |
| ABSTRACT | Wacker oxidation can be used as a signal transduction mechanism for the selective and sensitive detection of ethylene in air via chemiresistive sensing. Using this system, the senescence of lisianthus flowers and carnations can be monitored. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127292 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/122 (20130101) B01J 31/30 (20130101) B01J 31/0239 (20130101) B01J 31/0252 (20130101) B01J 2231/005 (20130101) B01J 2531/002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/127 (20130101) G01N 33/0098 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255228 | SALIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ColdQuanta, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan SALIM (Boulder, Colorado); Dana Zachary ANDERSON (Boulder, Colorado); Jayson DENNEY (Denver, Colorado); Farhad MAJDETEIMOURI (Broomfield, Colorado) |
| ABSTRACT | A 3D microwave sensor includes a cloud of particles, e.g., rubidium 87 atoms. A laser system produces: a first probe beam directed through the particle cloud along a first path; a second probe beam directed through the particle cloud along a second path that intersects the first path to define a Rydberg intersection; a first coupling beam that counterpropagates with respect to the first probe beam along the first path; and a second coupling beam that counterpropagates with respect to the second probe beam along the second path. A spectrum analyzer characterizes the microwave field strength at the Rydberg intersection. The laser beams can be steered to move the Rydberg intersection within the particle cloud to compile a microwave field strength distribution in the particle cloud. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/216883 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/0885 (20130101) Original (OR) Class G01R 33/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255258 | Barry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John F. Barry (Arlington, Massachusetts); Erik R. Eisenach (Cambridge, Massachusetts); Michael F. O'Keeffe (Medford, Massachusetts); Jonah A. Majumder (Cambridge, Massachusetts); Linh M. Pham (Arlington, Massachusetts); Isaac Chuang (Lexington, Massachusetts); Erik M. Thompson (Waltham, Massachusetts); Christopher Louis Panuski (Somerville, Massachusetts); Xingyu Zhang (Cambridge, Massachusetts); Danielle A. Braje (Winchester, Massachusetts) |
| ABSTRACT | Microwave resonator readout of the cavity-spin interaction between a spin defect center ensemble and a microwave resonator yields fidelities that are orders of magnitude higher than is possible with optical readouts. In microwave resonator readout, microwave photons probe a microwave resonator coupled to a spin defect center ensemble subjected to a physical parameter to be measured. The physical parameter shifts the spin defect centers' resonances, which in turn change the dispersion and/or absorption of the microwave resonator. The microwave photons probe these dispersion and/or absorption changes, yielding a measurement with higher visibility, lower shot noise, better sensitivity, and higher signal-to-noise ratio than a comparable fluorescence measurement. In addition, microwave resonator readout enables coherent averaging of spin defect center ensembles and is compatible with spin systems other than nitrogen vacancies in diamond. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188316 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) G01R 33/323 (20130101) G01R 33/1284 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255315 | Bobak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin P. Bobak (Silver Spring, Maryland); Hatim F. Alqadah (Ashburn, Virginia); Scott M. Rudolph (Washington, District of Columbia); Michael W. Nurnberger (Springfield, Virginia) |
| ABSTRACT | A microwave single pixel imager apparatus and method of using same. Sampling a targeted scene includes the following. A plurality of modulated antenna patterns is generated using a reflectarray. A plurality of antenna temperatures respectively corresponding to the plurality of modulated antenna patterns is measured. A retrieved scene corresponding to the sampled targeted scene is generated. Generating a retrieved scene corresponding to the sampled targeted scene includes the following. The plurality of modulated antenna patterns and the corresponding plurality of antenna temperatures are fed into a compressive sensing imaging algorithm. |
| FILED | Thursday, June 25, 2020 |
| APPL NO | 16/911417 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/03 (20130101) G01S 13/9021 (20190501) Original (OR) Class Antennas, i.e Radio Aerials H01Q 15/148 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255449 | Stonely et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Stonely (McKinney, Texas); Stephen Felix Sagan (Lexington, Massachusetts); Brian M. Graue (McKinney, Texas) |
| ABSTRACT | A telescope includes a primary mirror, a secondary mirror configured to move along a first axis, and a tertiary mirror configured to move along a second axis. The secondary and tertiary mirrors are configured to move along respective axes in a synchronized manner to focus a beam of electromagnetic radiation from the primary mirror. The telescope further may include an anamorphic deformable mirror configured to achieve wavefront control and correction of optical aberrations. The telescope further may include a first linear actuator configured to move the secondary mirror along the first axis and a second linear actuator configured to move the tertiary mirror along the second axis. |
| FILED | Thursday, December 26, 2019 |
| APPL NO | 16/727091 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 23/04 (20130101) G02B 23/06 (20130101) Original (OR) Class G02B 26/0825 (20130101) G02B 27/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255516 | Basu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Rajratan Basu (Annapolis, Maryland); Daniel Kinnamon (Annapolis, Maryland); Christopher M. Spillmann (Annandale, Virginia); Jakub Kolacz (Washington, District of Columbia); Jesse A. Frantz (Washington, District of Columbia); Jason D. Myers (Alexandria, Virginia) |
| ABSTRACT | A graphene and liquid crystal device comprising a substrate, a layer of graphene on the substrate, and a layer of liquid crystal on the layer of graphene. A graphene and liquid crystal device wherein the layer of graphene is an alignment layer and an electrode for a liquid crystal device. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308430 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/1337 (20130101) G02F 1/1418 (20130101) Original (OR) Class G02F 1/133711 (20130101) G02F 1/133738 (20210101) G02F 1/133753 (20130101) G02F 1/133757 (20210101) G02F 1/133796 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255518 | SUN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | YIFEI SUN (West Lafayette, Indiana); Shriram Ramanathan (West Lafayette, Indiana) |
| ABSTRACT | An electrochromic system is disclosed which includes a first glass layer having a bottom side and a top side, the top side coated with a first transparent conductor layer, an electrolyte layer formed adjacent to the first transparent conductor layer, an electrochromic layer formed adjacent to the electrolyte layer, and a second glass layer having a top side and a bottom side, the bottom side coated with a second transparent conductor layer and coupled to the electrochromic layer. |
| FILED | Wednesday, August 07, 2019 |
| APPL NO | 17/266100 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 17/10036 (20130101) B32B 17/10174 (20130101) B32B 17/10513 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/155 (20130101) G02F 1/1524 (20190101) Original (OR) Class G02F 1/1525 (20130101) G02F 1/13439 (20130101) G02F 1/133302 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255674 | Steely, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon C. Steely, JR. (Hudson, New Hampshire); Richard Dischler (Bolton, Massachusetts); David Bach (Shrewsbury, Massachusetts); Olivier Franza (Brookline, Massachusetts); William J. Butera (Newton, Massachusetts); Christian Karl (Hudson, Massachusetts); Benjamin Keen (Minneapolis, Minnesota); Brian Leung (Quincy, Massachusetts) |
| ABSTRACT | Embodiments herein may present an integrated circuit or a computing system having an integrated circuit, where the integrated circuit includes a physical network layer, a physical computing layer, and a physical memory layer, each having a set of dies, and a die including multiple tiles. The physical network layer further includes one or more signal pathways dynamically configurable between multiple pre-defined interconnect topologies for the multiple tiles, where each topology of the multiple pre-defined interconnect topologies corresponds to a communication pattern related to a workload. At least a tile in the physical computing layer is further arranged to move data to another tile in the physical computing layer or a storage cell of the physical memory layer through the one or more signal pathways in the physical network layer. Other embodiments may be described and/or claimed. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/174106 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/183 (20130101) Original (OR) Class G06F 9/5027 (20130101) G06F 15/76 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/5384 (20130101) H01L 23/5385 (20130101) H01L 23/5386 (20130101) H01L 25/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255910 | Flajslik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Mario Flajslik (Hudson, Massachusetts); James Dinan (Hopkinton, Massachusetts) |
| ABSTRACT | Systems, apparatuses and methods may provide for detecting an outbound communication and identifying a context of the outbound communication. Additionally, a completion status of the outbound communication may be tracked relative to the context. In one example, tracking the completion status includes incrementing a sent messages counter associated with the context in response to the outbound communication, detecting an acknowledgement of the outbound communication based on a network response to the outbound communication, incrementing a received acknowledgements counter associated with the context in response to the acknowledgement, comparing the sent messages counter to the received acknowledgements counter, and triggering a per-context memory ordering operation if the sent messages counter and the received acknowledgements counter have matching values. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 16/880277 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/52 (20130101) G06F 9/544 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256188 | Asadi-Zanjani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Navid Asadi-Zanjani (Gainesville, Florida); Nathan Jessurun (Gainesville, Florida); Mark M. Tehranipoor (Gainesville, Florida); Olivia Pauline Paradis (Gainesville, Florida) |
| ABSTRACT | There is a need for more effective and efficient printed circuit board (PCB) design. This need can be addressed by, for example, solutions for performing automated PCB component estimation. In one example, a method includes identifying a plurality of initial component estimations for the PCB; performing a shadow detection segmentation using the plurality of initial component estimations, a non-direct-lighting image, and one or more direct-lighting images to generate a first set of detected PCB components; performing a super-pixel segmentation using the plurality of initial component estimations and the non-direct-lighting-image to generate a second set of detected PCB components; and generating a bill of materials for the PCB based at least in part on the first set of detected PCB components and the second set of detected PCB components. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168529 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/392 (20200101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0006 (20130101) G06T 7/0008 (20130101) G06T 7/11 (20170101) G06T 2207/30141 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 3/0005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256305 | De La Houssaye et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States Government as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul R. De La Houssaye (San Diego, California); Benjamin J. Migliori (Santa Fe, New Mexico); Adi Ratan Bulsara (San Diego, California); Chriswell Hutchens (San Diego, California); Justin M. Mauger (San Diego, California) |
| ABSTRACT | A pattern recognition device comprising: a coupled network of damped, nonlinear, dynamic elements configured to generate an output response in response to at least one environmental condition, wherein each element has an associated multi-stable potential energy function that defines multiple energy states of an individual element, and wherein the elements are tuned such that environmental noise triggers stochastic resonance between energy levels of at least two elements; a processor configured to monitor the output response over time and to determine a probability that the pattern recognition device is in a given state based on the monitored output response; and detecting a pattern in the at least one environmental condition based on the probability. |
| FILED | Thursday, February 13, 2020 |
| APPL NO | 16/790567 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00986 (20130101) G06K 9/6248 (20130101) Original (OR) Class G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256314 | JAVIDI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bahram JAVIDI (Storrs Mansfield, Connecticut); Adam MARKMAN (Orange, Connecticut) |
| ABSTRACT | Described herein is an object recognition system in low illumination conditions. A 3D InIm system can be trained in the low illumination levels to classify 3D objects obtained under low illumination conditions. Regions of interest obtained from 3D reconstructed images are obtained by de-noising the 3D reconstructed image using total-variation regularization using an augmented Lagrange approach followed by face detection. The regions of interest are then inputted into a trained CNN. The CNN can be trained using 3D InIm reconstructed under low illumination after TV-denoising. The elemental images were obtained under various low illumination conditions having different SNRs. The CNN can effectively recognize the 3D reconstructed faces after TV-denoising. |
| FILED | Wednesday, August 07, 2019 |
| APPL NO | 17/251327 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00208 (20130101) G06K 9/2018 (20130101) G06K 9/3233 (20130101) G06K 9/6257 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256394 | TYMOSHENKO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stepan TYMOSHENKO (Emeryville, California); Oliver LIU (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods and systems for identifying variants of a given target protein or target gene that perform the same function and/or improve the phenotypic performance of a host cell transformed with such a variant. To enhance the diversity of identified candidate sequences, the methods may implement the use of a metagenomic database and/or machine learning methods. The methods and systems may be implemented in optimizing a biosynthetic pathway, e.g., to improve the production of a target molecule of interest. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175120 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/123 (20130101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256414 | Kachman et al. |
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| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tal Kachman (Haifa, Israel); Kenneth Lee Clarkson (Madison, New Jersey); Mark S. Squillante (Greenwich, Connecticut); Lior Horesh (North Salem, New York); Ismail Yunus Akhalwaya (Emmarentia, South Africa) |
| ABSTRACT | Systems, computer-implemented methods, and computer program products that can facilitate quantum topological classification are described. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise a topological component that employs one or more quantum computing operations to identify one or more persistent homology features of a topological simplicial structure. The computer executable components can further comprise a topological classifier component that employs one or more machine learning models to classify the topological simplicial structure based on the one or more persistent homology features. |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 16/576046 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/64 (20130101) G06K 9/6278 (20130101) G06K 9/6296 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256432 | ROSS et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isaac M. ROSS (Monterey, California); Ronald J. PROULX (Waban, Massachusetts); Mark KARPENKO (Salinas, California) |
| ABSTRACT | The invention relates to route planning and optimization. In some embodiments, the invention includes obtaining vertex data describing target attributes, including at least one target location, and process dynamics data describing system constraints of a process; defining vertex functionals, describing attribute requirements, and edge functionals, which use the system constraints to determine cost requirements, for cost objectives; and using the data, the functionals, and the cost objectives to construct a T-graph that includes a label space representing the target attributes. Next, the T-graph is solved to construct a label space trajectory by determining waypoints such that the process (1) travels through all target locations and (2) satisfies the attribute requirements, dynamically calculating travel cost by applying the cost requirements to each intervening edge, and minimizing the travel cost according to the cost objectives. The optimal space trajectory is executed to navigate the process through the target locations. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170875 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/13 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/047 (20130101) Original (OR) Class G06Q 10/06315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257410 | BrightSky et al. |
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| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew J. BrightSky (Armonk, New York); Cyril Cabral, JR. (Yorktown Heights, New York); Kenneth P. Rodbell (Sandy Hook, Connecticut) |
| ABSTRACT | A reactive material erasure element comprising a reactive material is located between PCM cells and is in close proximity to the PCM cells. The reaction of the reactive material is trigger by a current applied by a bottom electrode which has a small contact area with the reactive material erasure element, thereby providing a high current density in the reactive material erasure element to ignite the reaction of the reactive material. Due to the close proximity of the PCM cells and the reactive material erasure element, the heat generated from the reaction of the reactive material can be effectively directed to the PCM cells to cause phase transformation of phase change material elements in the PCM cells, which in turn erases data stored in the PCM cells. |
| FILED | Friday, November 22, 2019 |
| APPL NO | 16/692586 |
| CURRENT CPC | Static Stores G11C 13/003 (20130101) G11C 13/0004 (20130101) G11C 13/0059 (20130101) G11C 13/0069 (20130101) G11C 13/0097 (20130101) G11C 2013/008 (20130101) G11C 2213/50 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/2463 (20130101) Original (OR) Class H01L 45/06 (20130101) H01L 45/16 (20130101) H01L 45/143 (20130101) H01L 45/144 (20130101) H01L 45/1233 (20130101) H01L 45/1286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257511 | MI et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Royal Institution for the Advancement of Learning/McGill University (Montreal, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zetian MI (Verdun, Canada); Songrui ZHAO (Montreal, Canada); Renjie WANG (Montreal, Canada) |
| ABSTRACT | GaN-based nanowire heterostructures have been intensively studied for applications in light emitting diodes (LEDs), lasers, solar cells and solar fuel devices. Surface charge properties play a dominant role on the device performance and have been addressed within the prior art by use of a relatively thick large bandgap AlGaN shell covering the surfaces of axial InGaN nanowire LED heterostructures has been explored and shown substantial promise in reducing surface recombination leading to improved carrier injection efficiency and output power. However, these lead to increased complexity in device design, growth and fabrication processes thereby reducing yield/performance and increasing costs for devices. Accordingly, there are taught self-organising InGaN/AlGaN core-shell quaternary nanowire heterostructures wherein the In-rich core and Al-rich shell spontaneously form during the growth process. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/111184 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) Original (OR) Class H01L 33/007 (20130101) H01L 33/08 (20130101) H01L 33/18 (20130101) H01L 33/32 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/021 (20130101) H01S 5/1042 (20130101) H01S 5/32341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257616 | Tour et al. |
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| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | James M. Tour (Bellaire, Texas); Abdul-Rahman O. Raji (Houston, Texas); Rodrigo V. Salvatierra (Houston, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to electrodes that include a plurality of vertically aligned carbon nanotubes and a metal associated with the vertically aligned carbon nanotubes. The vertically aligned carbon nanotubes may be in the form of a graphene-carbon nanotube hybrid material that includes a graphene film covalently linked to the vertically aligned carbon nanotubes. The metal may become reversibly associated with the carbon nanotubes in situ during electrode operation and lack any dendrites or mossy aggregates. The metal may be in the form of a non-dendritic or non-mossy coating on surfaces of the vertically aligned carbon nanotubes. The metal may also be infiltrated within bundles of the vertically aligned carbon nanotubes. Additional embodiments pertain to energy storage devices that contain the electrodes of the present disclosure. Further embodiments pertain to methods of forming said electrodes by applying a metal to a plurality of vertically aligned carbon nanotubes. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 16/953588 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/06 (20130101) H01G 11/28 (20130101) H01G 11/36 (20130101) H01G 11/68 (20130101) H01G 11/86 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/045 (20130101) H01M 4/66 (20130101) H01M 4/366 (20130101) H01M 4/382 (20130101) H01M 4/587 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 4/661 (20130101) H01M 4/663 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257679 | Tour et al. |
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| FUNDED BY |
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| APPLICANT(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | James M. Tour (Bellaire, Texas); Tuo Wang (Houston, Texas); Rodrigo Villegas Salvatierra (Houston, Texas) |
| ABSTRACT | Systems and methods that utilize a separator coated by particles for Li dendrite detection in an ordinary two-electrode battery system. The particles can be red phosphorus (RP) particles and/or other particles that are poor electronic conductors, are able to react with Li, and will form an insoluble product with Li, such as silicon, germanium, arsenic, metal oxides, metal halides, metal chalcogenides, chalcogenides, and LiMxEyOz (M=metal, E=nonmetal, O=oxygen, x≥0, y≥0, z≥0). These other particles can be used by themselves or in combination with one another. No additional electrode is needed, and the presence of Li dendrites can be detected simply based on the voltage profile during the charging step. |
| FILED | Tuesday, June 11, 2019 |
| APPL NO | 16/973671 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/367 (20190101) G01R 31/392 (20190101) G01R 31/3842 (20190101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 10/48 (20130101) Original (OR) Class H01M 10/425 (20130101) H01M 10/0525 (20130101) H01M 50/431 (20210101) H01M 50/443 (20210101) H01M 50/449 (20210101) H01M 2010/4271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257799 | Pauzauskie et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Peter J. Pauzauskie (Seattle, Washington); Anupum Pant (Seattle, Washington); Xiaojing Xia (Seattle, Washington); Elena Dobretsova (Seattle, Washington); E. James Davis (Seattle, Washington); Alexander B. Bard (Seattle, Washington); Robert G. Felsted (Seattle, Washington) |
| ABSTRACT | An apparatus and method for cooling an optical fiber, comprising impinging electromagnetic radiation from a laser on an optical fiber comprising a core, in which the electromagnetic radiation is substantially confined, and a cladding, in thermal communication with the core, configured to provide optically activated cooling of the core via the electromagnetic radiation from the laser. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/160073 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0408 (20130101) Original (OR) Class H01S 3/06716 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258001 | Madison |
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| FUNDED BY |
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| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Gary M. Madison (Waltham, Massachusetts) |
| ABSTRACT | A CMOS divide by two circuit device comprising a two phase signal input, a first track and hold circuit, a second track and hold circuit, where the signal path from input to output of each track and hold circuit comprises a single switch and a single inverter. In hold mode the circuit device provides cross-coupled inverters with only two stable states, obviating the need for any dedicated start-up, initialization, or phase-forcing circuitry. In addition to its regular two-phase output, it can optionally provide a quadrature two-phase output, both having an output signal frequency equal to one half said input signal frequency. |
| FILED | Monday, September 16, 2019 |
| APPL NO | 16/571620 |
| CURRENT CPC | Pulse Technique H03K 3/037 (20130101) H03K 5/00006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258010 | Smith et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | W. Clarke Smith (New Haven, Connecticut); Jayameenakshi Venkatraman (New Haven, Connecticut); Xu Xiao (New Haven, Connecticut); Lucas Verney (Montrouge, France); Luigi Frunzio (North Haven, Connecticut); Shyam Shankar (New Haven, Connecticut); Mazyar Mirrahimi (New Haven, Connecticut); Michel Devoret (New Haven, Connecticut) |
| ABSTRACT | Techniques for modifying the Josephson potential of a transmon qubit by shunting the transmon with an inductance are described. The inclusion of this inductance may increase the confined potential of the qubit system compared with the conventional transmon, which may lead to a transmon qubit that is stable at much higher drive energies. The inductive shunt may serve the purpose of blocking some or all phase-slips between the electrodes of the qubit. As a result, the inductively shunted transmon may offer an advantage over conventional devices when used for applications involving high energy drives, whilst offering few to no drawbacks in comparison to conventional devices when used at lower drive energies. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 16/711002 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/18 (20130101) Pulse Technique H03K 17/92 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258080 | Sen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Shreyas Sen (West Lafayette, Indiana); Shovan Maity (West Lafayette, Indiana) |
| ABSTRACT | A method of using a HBC device includes enabling electro-quasistatic communication on a transmitter, wherein the enabling electro-quasistatic communication includes receiving an activation signal through an input. The enabling the electro-quasistatic communication additionally includes transmitting a digital data signal to a transmitter logic circuit. The enabling the electro-quasistatic communication further includes modulating an electro-quasistatic carrier signal by the digital data signal using a modulator, thereby producing a modulated electro-quasistatic signal. Additionally, the enabling the electro-quasistatic communication includes transmitting the electro-quasistatic signal from the transmitter logic circuit to a general purpose input output circuit. Furthermore, the enabling the electro-quasistatic communication includes coupling the electro-quasistatic signal on a human body through an electrode, thereby enabling electro-quasistatic communication. The transmitter includes the electrode. Next, the method includes transmitting the electro-quasistatic signal through the human body. Additionally, the method includes coupling the electro-quasistatic signal onto a receiver electrode. The receiver includes the receiver electrode. |
| FILED | Monday, September 21, 2020 |
| APPL NO | 17/027634 |
| CURRENT CPC | Transmission H04B 5/0012 (20130101) H04B 5/0031 (20130101) H04B 13/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258117 | Halepovic et al. |
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| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Emir Halepovic (Somerset, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Hulya Seferoglu (Chicago, Illinois); Muhammad Usama Chaudhry (Milpitas, California); Shibin Mathew (Chicago, Illinois); Shanyu Zhou (Chicago, Illinois); Balajee Vamanan (Chicago, Illinois) |
| ABSTRACT | Concepts and technologies directed to agile transport for background traffic in cellular networks are disclosed herein. In various aspects, a system can include a processor and memory storing instructions that, upon execution, cause performance of operations. The operations can include determining a capacity of a communication path that communicatively couples a user equipment to a radio access network cell site. The operations can include identifying, from the radio access network cell site, a queue that is constructed for the user equipment. The operations can include assembling a plurality of probe burst packet sets from a background traffic flow. The operations can include probing the communication path for spare capacity using the plurality of probe burst packet sets and delivering the background traffic flow to the user equipment using the spare capacity while the communication path is not busy. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/101015 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0048 (20130101) Original (OR) Class H04L 67/28 (20130101) Wireless Communication Networks H04W 72/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258471 | Stanard et al. |
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| FUNDED BY |
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| APPLICANT(S) | US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Terry W. Stanard (Dayton, Ohio); Theus H. Aspiras (Huber Heights, Ohio); Vijayan K. Asari (Dayton, Ohio); Taleri L. Hammack (Fairborn, Ohio) |
| ABSTRACT | A system includes a control station that enables efficient human collaboration with automated object tracking. The control station is communicatively coupled to an aerial vehicle to receive full motion video of a ground scene taken by an airborne sensor of the aerial vehicle. The control station spatially registers features of a movable object present in the ground scene and determines motion of the movable object relative to the ground scene. The control station predicts a trajectory of the movable objective relative to the ground scene. The control station tracks the movable object based on data fusion of: (i) the spatially registered features; (ii) the determined motion; and (iii) the predicted trajectory of the movable object. The control station presents a tracking annotation and a determined confidence indicator for the tracking annotation on a user interface device to facilitate human collaboration with object tracking. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/169660 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/246 (20170101) G06T 2207/10016 (20130101) G06T 2207/30232 (20130101) G06T 2207/30241 (20130101) Pictorial Communication, e.g Television H04N 5/28 (20130101) H04N 5/23216 (20130101) Original (OR) Class H04N 5/23218 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258531 | Gruev et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viktor Gruev (Urbana, Illinois); Missael Garcia (Urbana, Illinois) |
| ABSTRACT | A polarization imager is provided that includes a plurality of CMOS photodetectors and a plurality of polarization filters. Each of the plurality of CMOS photodetectors has a photodiode that is configured to operate in forward bias mode. Further, each of the plurality of polarization filters is monolithically integrated with a corresponding one of the plurality of CMOS photodetectors. Each of the plurality of photodiodes exhibits a logarithmic response to a flux of incident photons. The polarization imager achieves a dynamic range of at least 100 decibels with a signal-to-noise ratio of at least 60 decibels. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 16/585711 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14625 (20130101) H01L 27/14643 (20130101) Pictorial Communication, e.g Television H04N 5/37455 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210251237 | Kinkel |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linda L. Kinkel (Minneapolis, Minnesota) |
| ABSTRACT | The disclosure relates to a systemic platform for developing soil-borne plant pathogen inhibiting microbial consortia. The platform utilizes multivariate computer modelling and multidimensional ecological function balancing (MEFB) nodal analysis to develop microbial consortia, consortia, and inoculants. The disclosure further relates to a prescriptive biocontrol system that will enable farmers to have site-specific agricultural biologics developed for their specific site and crop of interest. |
| FILED | Thursday, July 25, 2019 |
| APPL NO | 17/262541 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/22 (20200101) Original (OR) Class A01N 63/28 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251256 | Gibbons et al. |
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| FUNDED BY |
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| APPLICANT(S) | Prairie Aqua Tech LLC (Brookings, South Dakota) |
| ASSIGNEE(S) | Prairie AquaTech (Brookings, South Dakota) |
| INVENTOR(S) | William Gibbons (Brookings, South Dakota); Michael Brown (Brookings, South Dakota) |
| ABSTRACT | The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/243315 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 1/14 (20130101) A23J 1/125 (20130101) Original (OR) Class A23J 1/148 (20130101) Fodder A23K 10/14 (20160501) A23K 10/38 (20160501) A23K 20/147 (20160501) A23K 40/20 (20160501) A23K 40/25 (20160501) A23K 50/80 (20160501) Technologies for Adaptation to Climate Change Y02A 40/818 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251574 | Halter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Halter (Lyme, New Hampshire); Gunnar C. Pope (Lebanon, New Hampshire) |
| ABSTRACT | A microcontroller for recording and storing physiological data includes an analog-to-digital converter for converting analog physiological sensor signals to digital signals, a sample buffer for holding a temporal sequence of the digital signals, a central processing unit (CPU), and a non-volatile memory. The non-volatile memory includes (i) a code storage encoding machine-readable data compression instructions that, when executed by the CPU, control the CPU to (a) transform the temporal sequence of the digital signals to produce transformed physiological data characterized by a set of transformation coefficients and (b) compress the set of transformation coefficients to generate compressed physiological data, and (ii) a data storage configured to contain several different instances of the compressed physiological data respectively associated with several different instances of the temporal sequence of the digital signals. |
| FILED | Friday, August 23, 2019 |
| APPL NO | 17/270971 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/08 (20130101) A61B 5/369 (20210101) A61B 5/389 (20210101) A61B 5/681 (20130101) A61B 5/726 (20130101) A61B 5/02405 (20130101) A61B 5/7225 (20130101) A61B 5/7232 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251839 | Huber et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meghan Huber (Salem, Massachusetts); James Hermus (Oregon, Wisconsin); Gabrielle Enns (Boston, Massachusetts); Neville Hogan (Sudbury, Massachusetts) |
| ABSTRACT | In some embodiments, a body anchor for supporting an assistive device can include: a cuff to exert a compression force on a body part of a user; and one or more tensile elements having first ends and second ends. The first ends of the tensile elements can be configured to be attached to the assistive device. The second ends of the tensile elements can be arranged about the cuff to cause the compression force to vary in proportion to a load exerted by the assistive device. |
| FILED | Thursday, February 13, 2020 |
| APPL NO | 16/789638 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/0104 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 3/00 (20130101) Original (OR) Class A61H 2003/007 (20130101) A61H 2201/14 (20130101) A61H 2201/164 (20130101) A61H 2201/1645 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251958 | Ausubel et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); RHODE ISLAND HOSPITAL, A LIFESPAN-PARTNER (Providence, Rhode Island); EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederick M. Ausubel (Newton, Massachusetts); Wooseong Kim (Providence, Rhode Island); Eleftherios Mylonakis (Providence, Rhode Island); William M. Wuest (Atlanta, Georgia) |
| ABSTRACT | The present application provides compounds of formula: Methods of using these compounds for killing bacterial growth and treating bacterial infections are also provided. |
| FILED | Wednesday, April 10, 2019 |
| APPL NO | 17/046463 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) A61K 31/404 (20130101) Original (OR) Class A61K 31/4439 (20130101) A61K 31/7036 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 209/36 (20130101) C07D 209/42 (20130101) C07D 401/06 (20130101) C07D 403/04 (20130101) C07D 405/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252169 | Naczynski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Dominik J. Naczynski (Wallington, New Jersey); Mei-Chee Tan (Singapore, Singapore); Richard E. Riman (Piscataway, New Jersey); Charles Roth (Princeton, New Jersey); Prabhas V. Moghe (Basking Ridge, New Jersey) |
| ABSTRACT | Compositions for biomedical applications are disclosed, containing infrared-emitting particles, which contain rare earth-elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form down-converting encapsulated particles and can optionally further include a contrast agent or radiolabel and be used as multimodal imaging agents, where the multimodal-imaging scheme can be selected from optical/MRI, optical/X-ray imaging, optical/CT, optical/PET and combinations thereof. Multimodal imaging methods are also disclosed. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/234669 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/0075 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0019 (20130101) A61K 49/0065 (20130101) Original (OR) Class A61K 49/0093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252483 | da Silva et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcia Renata Quadros da Silva (Oak Creek, Wisconsin); David Garman (Lindfield, Australia); Mohsen Manjili (Glendale, Wisconsin); Yan Zhang (Tianjin, China PRC) |
| ABSTRACT | Zeolites functionalized with graphene oxide, reduced graphene oxide, or a sulfide have utility in removing pollutants from a water supply. Pollutants include Persistent Organic Pollutants (POPs) and heavy metals, such as lead. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/153792 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/262 (20130101) B01J 20/3071 (20130101) B01J 20/3078 (20130101) B01J 20/3085 (20130101) B01J 20/3204 (20130101) Original (OR) Class B01J 20/3223 (20130101) B01J 20/3234 (20130101) B01J 20/3285 (20130101) B01J 2220/46 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/23 (20170801) C01B 2204/04 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2002/85 (20130101) C01P 2004/03 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/281 (20130101) C02F 1/283 (20130101) C02F 1/285 (20130101) C02F 1/288 (20130101) C02F 2101/345 (20130101) C02F 2305/04 (20130101) C02F 2305/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252493 | Goodson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Board of Trustees of Southern Illinois University (Carbondale, Illinois); Vanderbilt University (Nashville, Tennessee); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Boyd M. Goodson (Carbondale, Illinois); Eduard Y. Chekmenev (Troy, Michigan); Igor V. Koptyug (Novosibirsk, Russian Federation); Kirill V. Kovtunov (Novosibirsk, Russian Federation); Roman V. Shchepin (Nashville, Tennessee); Bryce E. Kidd (Carbondale, Illinois); Jonathan Gesiorski (Hickory Hills, Illinois); Max E. Gemeinhardt (Carbondale, Illinois); Danila A. Barskiy (Berkeley, California) |
| ABSTRACT | The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described. |
| FILED | Monday, February 17, 2020 |
| APPL NO | 16/792637 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1616 (20130101) B01J 31/2273 (20130101) B01J 31/2295 (20130101) B01J 31/4038 (20130101) Original (OR) Class B01J 38/02 (20130101) B01J 38/68 (20130101) B01J 2531/827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252699 | Ramani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karthik Ramani (West Lafayette, Indiana); Ke Huo (Unico City, California); Yuanzhi Cao (Redmond, Washington); Tianyi Wang (West Lafayette, Indiana) |
| ABSTRACT | A system and method for authoring and performing Human-Robot-Collaborative (HRC) tasks is disclosed. The system and method adopt an embodied authoring approach in Augmented Reality (AR), for spatially editing the actions and programming the robots through demonstrative role-playing. The system and method utilize an intuitive workflow that externalizes user's authoring as demonstrative and editable AR ghost, allowing for spatially situated visual referencing, realistic animated simulation, and collaborative action guidance. The system and method utilize a dynamic time warping (DTW) based collaboration model which takes the real-time captured motion as inputs, maps it to the previously authored human actions, and outputs the corresponding robot actions to achieve adaptive collaboration. |
| FILED | Wednesday, September 16, 2020 |
| APPL NO | 17/022216 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1605 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252773 | Wegst et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Ulrike G. K. Wegst (Hanover, New Hampshire); Kaiyang Yin (West Lebanon, New Hampshire); Claire Adner (Hanover, New Hampshire); Peyton Weber (Hanover, New Hampshire); Amalie Hildebrandt Brynjulfsson (Hanover, New Hampshire) |
| ABSTRACT | In an aspect, the present disclosure pertains to a method of making a material. Generally, the method includes one or more of the following steps of: (1) placing a mixture having one or more components in a container; and (2) extruding the mixture out of at least one opening of at least one nozzle. In an additional aspect, the present disclosure pertains to a material. In some embodiments, the material includes one or more components. In some embodiments, the one or more components are in the form of a multi-layered structure. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/176058 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/255 (20170801) B29C 64/314 (20170801) B29C 64/393 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2023/22 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/10 (20200101) B33Y 50/02 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252777 | ANGELINI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Ettor ANGELINI (Gainesville, Florida); Wallace Gregory SAWYER (Gainesville, Florida); Kyle Gene ROWE (Gainesville, Florida); Tapomoy BHATTACHARJEE (Kolkata, India); Alberto FERNANDEZ-NIEVES (Suwanee, Georgia); Ya-Wen CHANG (Atlanta, Georgia); Samantha M. MARQUEZ (New Haven, Connecticut) |
| ABSTRACT | A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/233626 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/30942 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/18 (20130101) A61L 27/26 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/60 (20130101) A61L 27/507 (20130101) A61L 27/3604 (20130101) A61L 27/3625 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/069 (20130101) C12N 5/0686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253434 | PEGNA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| ASSIGNEE(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| INVENTOR(S) | Joseph PEGNA (Saratoga Springs, New York); John L. SCHNEITER (Cohoes, New York); Kirk L. WILLIAMS (Saratoga Springs, New York); Ramkiran GODUGUCHINTA (Ballston Lake, New York) |
| ABSTRACT | A method and apparatus for forming a plurality of fibers from (e.g., CVD) precursors, including a reactor adapted to grow a plurality of individual fibers; and a plurality of independently controllable lasers, each laser of the plurality of lasers growing a respective fiber. A high performance fiber (HPF) structure, including a plurality of fibers arranged in the structure; a matrix disposed between the fibers; wherein a multilayer coating is provided along the surfaces of at least some of the fibers with an inner layer region having a sheet-like strength; and an outer layer region, having a particle-like strength, such that any cracks propagating toward the outer layer from the matrix propagate along the outer layer and back into the matrix, thereby preventing the cracks from approaching the fibers. A method of forming an interphase in a ceramic matrix composite material having a plurality of SiC fibers, which maximizes toughness by minimizing fiber to fiber bridging, including arranging a plurality of SiC fibers into a preform; selectively removing (e.g., etching) silicon out of the surface of the fibers resulting in a porous carbon layer on the fibers; and replacing the porous carbon layer with an interphase layer (e.g., Boron Nitride), which coats the fibers to thereby minimize fiber to fiber bridging in the preform. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/087092 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/956 (20170801) Original (OR) Class Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/76 (20130101) C04B 35/515 (20130101) C04B 35/565 (20130101) C04B 35/62865 (20130101) C04B 35/62868 (20130101) C04B 35/62873 (20130101) C04B 2235/616 (20130101) C04B 2235/3409 (20130101) C04B 2235/5244 (20130101) C04B 2235/5264 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/08 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/16 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/249964 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253630 | Minden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Minden (Pittsburgh, Pennsylvania); Amber Lucas (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are methods, reagents, and kits for isolating polypeptides, such as a proteome. Also provided herein is a modified trypsin polypeptide that is resistant to autolysis, and that can be selectively-separated from a biological sample once digestion is complete. |
| FILED | Friday, June 07, 2019 |
| APPL NO | 16/972923 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/12 (20130101) Peptides C07K 1/10 (20130101) C07K 1/14 (20130101) Original (OR) Class C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6427 (20130101) Enzymes C12Y 304/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253800 | Wynne et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Commonwealth University (Richmond, Virginia) |
| ASSIGNEE(S) | Virginia Commonwealth University (Richmond, Virginia) |
| INVENTOR(S) | Kenneth J. Wynne (Midlothian, Virginia); Ashraf KAYESH (Richmond, Virginia) |
| ABSTRACT | A surface-modified poly(dimethylsiloxane) is provided, comprising a Pt-cured poly(dimethylsiloxane) elastomer, having a surface; and a plurality of —CH2—CH2—R groups covalently bound to the surface; wherein R is a substituted or unsubstituted, branched or unbranched alkyl, aryl, aralkyl, alkylsilyl, silyl, alkyl ether, alkyl amine, quaternary alkyl amine, or alkylcarbonyloxy group. Methods of making and using the surface-modified poly(dimethylsiloxane) are also provided. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284595 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/12 (20130101) C08G 77/20 (20130101) C08G 77/388 (20130101) Original (OR) Class Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 183/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253811 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng Jiang (Gainesville, Florida); Sin-Yen Leo (Hillsboro, Oregon); Calen Leverant (Gainesville, Florida); Danielle Liu (Nashville, Tennessee); Yin Fang (Gainesville, Florida) |
| ABSTRACT | Described herein are methods and compositions relating to tunable nanoporous coatings. In certain aspects, described herein are methods and compositions wherein a tunable nanoporous coating comprises a tunable nanoporous membrane which transitions from opaque to transparent upon the application of force, and from transparent to opaque after washing with a solvent. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230160 |
| CURRENT CPC | Separation B01D 69/125 (20130101) B01D 71/40 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 22/1006 (20200201) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) Original (OR) Class C08J 7/02 (20130101) Optical Elements, Systems, or Apparatus G02B 1/111 (20130101) G02B 5/0247 (20130101) G02B 5/0268 (20130101) G02B 5/0294 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253820 | Smalyukh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ivan I. Smalyukh (Boulder, Colorado); Andrew Johnston Hess (Louisville, Colorado); Quingkun Liu (Boulder, Colorado); Joshua A. De La Cruz (Denver, Colorado); Blaise Fleury (Boulder, Colorado); Eldho Abraham (Boulder, Colorado); Bohdan Senyuk (Boulder, Colorado); Vladyslav Cherpak (Westminster, Colorado) |
| ABSTRACT | Disclosed are cellulose-based 5 flexible aerogels and xerogels containing bacterial cellulose nanorods, ribbons, fibers, and the like, wherein the gels have tunable optical, heat transfer, and stiffness properties. Further disclosed are highly transparent and flexible cellulose nanofiber-polysiloxane composite aerogels featuring enhanced mechanical robustness, tunable optical anisotropy, and low thermal conductivity. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 17/251694 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 9/28 (20130101) Original (OR) Class C08J 2201/026 (20130101) C08J 2201/0504 (20130101) C08J 2205/026 (20130101) C08J 2205/028 (20130101) C08J 2301/02 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/544 (20130101) C08K 7/02 (20130101) C08K 2201/011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253876 | Zalich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Andrew Zalich (Wexford, Pennsylvania); Michael F. Baxter (New Kensington, Pennsylvania); Paul H. Berdahl (Walnut Creek, California); Stuart D. Hellring (Pittsburgh, Pennsylvania); Jeffrey Lynn Stalker (Wexford, Pennsylvania) |
| ABSTRACT | The present invention provides for a composition comprising a pigment, wherein the composition is suitable for coating a surface that is, or is expected to be, exposed to the sun. The pigment comprises particles that fluoresce in sunlight, thereby remaining cooler in the sun than coatings pigmented with non-fluorescent particles. The particles comprise solids that fluoresce or glow in the visible or near infrared (NIR) spectra, or that fluoresce when doped. Suitable dopants include, but are not limited to, ions of rare earths and transition metals. A coating composition includes: (i) a film-forming resin; (ii) an infrared reflective pigment; and (iii) an infrared fluorescent pigment different from the infrared reflective pigment. When the coating composition is cured to form a coating and exposed to radiation comprising fluorescence-exciting radiation, the coating has a greater effective solar reflectance (ESR) compared to the same coating exposed to the radiation comprising fluorescence-exciting radiation except without the infrared fluorescent pigment. A multi-layer coating including the coating composition, and a substrate at least partially coated with the coating composition is also disclosed. A method of reducing temperature of an article includes applying the coating composition to at least a portion of the article. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162284 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 3/06 (20130101) B05D 5/06 (20130101) B05D 7/14 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/004 (20130101) C09D 5/22 (20130101) Original (OR) Class C09D 5/32 (20130101) C09D 5/38 (20130101) C09D 7/61 (20180101) C09D 7/62 (20180101) C09D 127/16 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/54 (20130101) C09K 11/562 (20130101) C09K 11/685 (20130101) C09K 11/883 (20130101) C09K 11/7704 (20130101) C09K 11/7706 (20130101) C09K 11/7772 (20130101) C09K 11/7774 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253881 | Harris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tequila A. L. Harris (Atlanta, Georgia); Kyriaki Kalaitzidou (Atlanta, Georgia); Yuhan Xiao (Atlanta, Georgia); Donggang Yao (Atlanta, Georgia) |
| ABSTRACT | In a method of depositing a fibroin structure, a fibroin ink is generated. The fibroin ink is aerosol jet printed onto a substrate. To prepare the ink, a plurality of biologically-generated silk cocoons are each cut into at least two pieces of raw silk and are degummed to remove sericin, leaving fibroin fibers. The fibroin fibers are dissolved into a lithium bromide solution. The salt is removed by placing the fibroin/salt solution in a dialysis membrane tube and submerging it in deionized water. The fibroin solution is centrifuged to remove impurities therefrom, leaving fibroin ink. The fibroin ink is atomized into a fibroin ink aerosol, which is directed to a print nozzle. A focusing gas sheath is directed around the print nozzle to deposit fibroin onto a surface. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/177631 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/12 (20130101) Typewriters; Selective Printing Mechanisms,, i.e Mechanisms Printing Otherwise Than From a Forme; Correction of Typographical Errors B41J 2/215 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/08 (20130101) Original (OR) Class C09D 11/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253923 | Shi |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington State University (Pullman, Washington) |
| ASSIGNEE(S) | Washington State University (Pullman, Washington) |
| INVENTOR(S) | Xianming Shi (Pullman, Washington) |
| ABSTRACT | A deicing formulation, comprising a chemically degraded extract derived from biowaste; and a salt is provided. Methods for preventing ice formation or removing ice from a surface by applying the deicing formula made of chemically degraded extract derived from biowaste and a salt to the surface are also provided. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/173080 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 3/185 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254026 | Clarke et al. |
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| FUNDED BY |
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| APPLICANT(S) | Industrial Microbes, Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Jane Clarke (San Francisco, California); Baolong Zhu (San Diego, California); Derek Lorin Greenfield (Kensington, California); Stephanie Rhianon Jones (Berkeley, California); Noah Charles Helman (El Cerrito, California) |
| ABSTRACT | Methods and compositions for the oxidation of short alkanes by engineered microorganisms expressing enzymes are described, along with methods of use. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149394 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/0073 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) C12P 7/06 (20130101) C12P 7/22 (20130101) Enzymes C12Y 114/13025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254070 | SCHULMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (BALTIMORE, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | REBECCA B. SCHULMAN (BALTIMORE, Maryland); DOMINIC SCALISE (BALTIMORE, Maryland) |
| ABSTRACT | The present disclosure provides systems, compositions, and methods related to oligonucleotide buffers for use in generating molecular circuits and their application to DNA nanostructure formation and growth. In particular, the present disclosure provides materials and methods for modulating polynucleotide concentrations using DNA strand-displacement to control molecular reactions for various applications, such as drug delivery, RNA-based therapeutics, chemical synthesis, and nanostructure assembly. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/271549 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254239 | DOLGOS et al. |
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| FUNDED BY |
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| APPLICANT(S) | OREGON STATE UNIVERSITY (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle DOLGOS (Corvallis, Oregon); Dylan FAST (Corvallis, Oregon); May NYMAN (Corvallis, Oregon); Brady J. GIBBONS (Corvallis, Oregon); Matthew O. CLARK (Corvallis, Oregon) |
| ABSTRACT | Embodiments disclosed herein include potassium sodium niobate (KNN) films and methods of making such films. In an embodiment, a method of forming a potassium sodium niobate (KNN) film comprises preparing a solution comprising water, potassium hexaniobate salts, and sodium hexaniobate salts. In an embodiment, the solution is spin coated onto a substrate to form a film on at least a portion of a surface of the substrate. In an embodiment, the method may further comprise heat treating the film. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 16/972997 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/005 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 33/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/40 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/04 (20130101) C30B 29/30 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/317 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255132 | Alba Rubio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Toledo (Toledo, Ohio) |
| ASSIGNEE(S) | The University of Toledo (Toledo, Ohio) |
| INVENTOR(S) | Ana C. Alba Rubio (Toledo, Ohio); Dong-Shik Kim (Toledo, Ohio); Surachet Duanghathaipornsuk (Toledo, Ohio) |
| ABSTRACT | Compositions, devices, and methods for sensing free radicals such as hydroxyl radicals, involving cerium oxide nanoparticles on a carbon-based substrate, are described. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178455 |
| CURRENT CPC | Separation B01D 69/02 (20130101) B01D 69/148 (20130101) B01D 71/024 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/308 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0687 (20130101) H01M 8/1051 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255159 | Swager et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Timothy Swager (Newton, Massachusetts); Darryl Fong (Boston, Massachusetts); Shaoxiong Luo (Cambridge, Massachusetts); Rafaela Da Silveira Andre (Cambridge, Massachusetts) |
| ABSTRACT | Wacker oxidation can be used as a signal transduction mechanism for the selective and sensitive detection of ethylene in air via chemiresistive sensing. Using this system, the senescence of lisianthus flowers and carnations can be monitored. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127292 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/122 (20130101) B01J 31/30 (20130101) B01J 31/0239 (20130101) B01J 31/0252 (20130101) B01J 2231/005 (20130101) B01J 2531/002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/127 (20130101) G01N 33/0098 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255186 | Panchapakesan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts); University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Balaji Panchapakesan (Worcester, Massachusetts); Farhad Khosravi (Worcester, Massachusetts); Shesh N. Rai (Louisville, Kentucky) |
| ABSTRACT | The present disclosure provides micro-array devices for capturing cells in blood and methods of their use. In some aspects, a method for counting cells in a blood sample is provided, the method comprising applying a blood sample onto a CNT device; allowing cells in the blood sample to differentially settle on the CNT device, and identifying and counting cells of preselected type in the blood sample. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231533 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 15/1056 (20130101) G01N 27/125 (20130101) G01N 27/127 (20130101) G01N 33/574 (20130101) Original (OR) Class G01N 33/5748 (20130101) G01N 33/57415 (20130101) G01N 33/57492 (20130101) G01N 2015/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255314 | Tavassolian et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| INVENTOR(S) | Negar Tavassolian (Hoboken, New Jersey); Amir Mirbeik-Sabzevari (Hoboken, New Jersey) |
| ABSTRACT | The present disclosure relates to an apparatus and method for synthetically making an ultra-wide imaging bandwidth in millimeter-wave frequencies, resulting in improved image resolutions to values previously unattained. The synthetic approach sums up a number of available sub-bands (channels) to build an unavailable ultra-wideband system. Each channel contains an antenna unit which is optimized for operation within that specific sub-band. The number and position of the channels can be adjusted to cover any frequency range as required for the specific application. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228515 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/05 (20130101) A61B 5/444 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/89 (20130101) G01S 13/90 (20130101) Original (OR) Class G01S 13/0209 (20130101) Antennas, i.e Radio Aerials H01Q 13/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255464 | Hua et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona); AUGMENTED VISION, INC (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hong Hua (Tucson, Arizona); Chunyu Gao (Tucson, Arizona) |
| ABSTRACT | Eye-tracked head-mounted displays are provide which, in one aspect, may utilize the same optics for eyetracking and image viewing, with a selected portion of the optics used for an eyetracking optical path and a selected portion of the display optics used for an image viewing optical path. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/160492 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 17/086 (20130101) G02B 17/0896 (20130101) G02B 27/017 (20130101) G02B 27/0093 (20130101) G02B 27/0172 (20130101) Original (OR) Class G02B 2027/011 (20130101) G02B 2027/0138 (20130101) G02B 2027/0187 (20130101) Electric Digital Data Processing G06F 3/013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255488 | Piestun et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Rafael Piestun (Boulder, Colorado); Omer Tzang (Boulder, Colorado); Eyal Niv (Boulder, Colorado) |
| ABSTRACT | Controlling the propagation and interaction of light in complex media has sparked major interest. Unfortunately, spatial light modulation devices suffer from limited speed precluding real-time applications (e.g., imaging in live tissue). To address this problem, various embodiments use a phase-control technique to characterize complex media based on use of fast 1D spatial modulators and 1D-to-2D transformation performed by the same medium being analyzed. Some embodiments use a micro-electro-mechanical grating light valve (GLV) with 1088 degrees of freedom modulated at 350 KHz, enabling unprecedented high-speed wavefront measurements. Some embodiments continuously measure the transmission matrix, calculate the optimal wavefront and project a focus through various dynamic scattering samples in real-time, (e.g., within 2.4 ms per cycle). As such, some embodiments improve, by more than an order of magnitude, prior wavefront shaping modulation speed and open new opportunities for optical processing using 1D-to-2D transformations. |
| FILED | Monday, August 26, 2019 |
| APPL NO | 17/271135 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/48 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0121 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255518 | SUN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | YIFEI SUN (West Lafayette, Indiana); Shriram Ramanathan (West Lafayette, Indiana) |
| ABSTRACT | An electrochromic system is disclosed which includes a first glass layer having a bottom side and a top side, the top side coated with a first transparent conductor layer, an electrolyte layer formed adjacent to the first transparent conductor layer, an electrochromic layer formed adjacent to the electrolyte layer, and a second glass layer having a top side and a bottom side, the bottom side coated with a second transparent conductor layer and coupled to the electrochromic layer. |
| FILED | Wednesday, August 07, 2019 |
| APPL NO | 17/266100 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 17/10036 (20130101) B32B 17/10174 (20130101) B32B 17/10513 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/155 (20130101) G02F 1/1524 (20190101) Original (OR) Class G02F 1/1525 (20130101) G02F 1/13439 (20130101) G02F 1/133302 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255726 | Colgate et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Edward Colgate (Evanston, Illinois); Michael A. Peshkin (Evanston, Illinois); John Glassmire (Seattle, Washington); Laura Winfield Alexander (Sunbury, Ohio) |
| ABSTRACT | A device including a body configured to be grasped by a user's hand and a touch surface oriented on a first surface of the body, wherein the touch surface is configured to be engaged by an appendage of the user's hand when the body is grasped by the user's hand. The device also includes a friction modulator associated with the touch surface, wherein the friction modulator is configured to modulate a coefficient of friction between the user's appendage and the touch surface to provide haptic feedback. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/223452 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/016 (20130101) G06F 3/041 (20130101) G06F 3/045 (20130101) G06F 3/0362 (20130101) G06F 3/0414 (20130101) Original (OR) Class G06F 3/0421 (20130101) G06F 2203/04104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255836 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Shuqing Chen (Woodland Hills, California); Michelle Effros (Pasadena, California); Victoria Kostina (Pasadena, California) |
| ABSTRACT | Systems and methods in accordance with various embodiments of the invention perform lossless source coding. In several embodiments, a nested code structure is utilized to perform Random Access Source Coding (RASC), where the number of active encoders is initially unknown. In several embodiments, the decoder can attempt to decode using a number of Slepian-Wolf decoders corresponding to an estimated number of sources. One embodiment includes multiple source encoders configured to receive a start message and transmit a portion of a codeword selected by encoding data from a source until an end of epoch message is received. A source decoder can transmit at least one start message, and receive codeword portions transmitted by the plurality of source encoders. When a decoding rule is satisfied, the source decoder can decode data from multiple source encoders based upon received codeword portions, and cause the broadcast transmitter to transmit an end of epoch message. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/155001 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256345 | Mars et al. |
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| FUNDED BY |
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| APPLICANT(S) | Clinc, Inc. (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Mars (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Michael Laurenzano (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan) |
| ABSTRACT | Systems and methods for implementing an artificially intelligent virtual assistant includes collecting a user query; using a competency classification machine learning model to generate a competency label for the user query; using a slot identification machine learning model to segment the text of the query and label each of the slots of the query; generating a slot value for each of the slots of the query; generating a handler for each of the slot values; and using the slot values to: identify an external data source relevant to the user query, fetch user data from the external data source, and apply one or more operations to the query to generate response data; and using the response data, to generate a response to the user query. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231269 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/006 (20130101) Original (OR) Class G06N 3/08 (20130101) G06N 20/00 (20190101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/18 (20130101) G10L 15/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256383 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanzhi Wang (Newton Highlands, Massachusetts); Yifan Gong (Boston, Massachusetts); Zheng Zhan (Boston, Massachusetts) |
| ABSTRACT | A privacy-preserving DNN model compression framework allows a system designer to implement a pruning scheme on a pre-trained model without the access to the client's confidential dataset. Weight pruning of the DNN model is formulated without the original dataset as two sets of optimization problems with respect to pruning the whole model or each layer are solved successfully with an ADMM optimization framework. The system allows data privacy to be preserved and real-time inference to be achieved while maintaining accuracy on large-scale DNNs. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176340 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256384 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts); College of William and Mary (Williamsburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanzhi Wang (Newton Highlands, Massachusetts); Xiaolong Ma (Boston, Massachusetts); Wei Niu (Jamestown, Virginia); Bin Ren (Jamestown, Virginia) |
| ABSTRACT | PatDNN is an end-to-end framework to achieve real-time DNN execution on mobile devices. PatDNN includes two stages: a pattern-based pruning stage based on extended ADMM solution framework, and an optimized execution code generation stage including a high-level, fine-grained DNN layerwise representation and a set of architecture-aware optimizations. This design allows PatDNN to benefit from both high accuracy and hardware efficiency. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176464 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256385 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanzhi Wang (Newton Highlands, Massachusetts); Xiaolong Ma (Boston, Massachusetts) |
| ABSTRACT | A computer-implemented method is disclosed for compressing a deep neural network (DNN) model by DNN weight pruning to accelerate DNN inference on mobile devices. The method includes the steps of (a) performing an intra-convolution kernel pruning of the DNN model wherein a fixed number of weights are pruned in each convolution kernel of the DNN model to generate sparse convolution patterns; (b) performing inter-convolution kernel pruning of the DNN model to generate connectivity sparsity, wherein inter-convolution kernel pruning comprises cutting connections between given input and output channels of the DNN model to remove corresponding kernels; and (c) training the DNN model compressed in steps (a) and (b). |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176742 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6249 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256406 | MUELLER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Klaus MUELLER (New York, New York); Jun WANG (Lynbrook, New York) |
| ABSTRACT | A system and method associated with generating an interactive visualization of causal models used in analytics of data is disclosed. The system performs various operations that include receiving time series data in the analytics of time-based phenomena associated with a data set. The system generates a visual representation to specify an effect associated with a causal relation. A causal hypothesis is determined using at least one of an effect variable and a cause variable associated with the visual representation. Causal events are identified in a new visual representation with a time shift being set. A statistical significance is determined using at least one time window within the new visual representation. An updated visual representation is generated including one or more updated causal models. A corresponding method and computer-readable medium are also disclosed. |
| FILED | Monday, July 08, 2019 |
| APPL NO | 16/973319 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/287 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6226 (20130101) Computer Systems Based on Specific Computational Models G06N 5/046 (20130101) Original (OR) Class G06N 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256635 | Cali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EnergyXchain, LLC (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Umit Cali (Kassel Hesse, Germany); David A. Doctor (Huntersville, North Carolina); Robert W. Norris (Charlotte, North Carolina) |
| ABSTRACT | Methods and systems for improved creation, monitoring, and updating of energy transactions are provided. In one embodiment, a method is provided that includes receiving a request to originate a contract for an energy transaction. Transaction information concerning the energy transaction may be received and may identify a type of energy resource and parties for the energy transaction. A requirement for the energy transaction may be identified within the contract codex and at least one condition may be determined based on the requirement. An updated contract may be generated by adding the at least one condition to the contract. Information regarding the updated contract may be stored on the distributed ledger. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/178028 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2379 (20190101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256692 | Popescu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel Popescu (Champaign, Illinois); Mikhail Eugene Kandel (Champaign, Illinois); Yuchen He (Urbana, Illinois); Nahil A. Sobh (Urbana, Illinois); Matthew Benjamin Wheeler (Tolono, Illinois); Marcello Rubessa (Middleton, Wisconsin) |
| ABSTRACT | A system generates a context mask based on quantitative image data. The system obtains the quantitative image data which was captured via a quantitative imaging of a sample. The quantitative image data is compared to previous quantitative image data through application of the quantitative image data to a neural network trained using the previous quantitative image data and corresponding constructed context masks. The comparison generates the context mask for the quantitative image data. The context mask provides context for the quantitative parameter values that facilities characterization of the sample. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178486 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/10072 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256765 | Huo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ke Huo (West Lafayette, Indiana); Karthik Ramani (West Lafayette, Indiana) |
| ABSTRACT | A method and system for enabling a self-localizing mobile device to localize other self-localizing mobile devices having different reference frames is disclosed. Multiple self-localizing mobile devices are configured to survey an environment to generate a three-dimensional map of the environment using simultaneous localization and mapping (SLAM) techniques. The mobile devices are equipped with wireless transceivers, such as Ultra-wideband radios, for measuring distances between the mobile devices using wireless ranging techniques. Based on the measured distances and self-localized positions in the environment corresponding to each measured distance, at least one of the mobile devices is configured to determine relative rotational and translational transformations between the different reference frames of the mobile devices. Based on the determined transformations, the mobile devices are able to localize the other mobile devices in their own reference frames, which can enable a variety of spatially aware augmented reality features and interactions. |
| FILED | Wednesday, February 27, 2019 |
| APPL NO | 17/056563 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 15/20 (20130101) G06T 19/006 (20130101) Original (OR) Class G06T 2200/08 (20130101) G06T 2200/24 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) H04L 67/18 (20130101) Wireless Communication Networks H04W 4/023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257451 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Alexander Robinson (Spring Mills, Pennsylvania); Rafael Vila (Sierra Vista, Arizona) |
| ABSTRACT | The present invention relates to methods for fabricating vertical homogenous and heterogeneous two-dimensional structures, the fabricated vertical two-dimensional structures, and methods of using the same. The methods demonstrated herein produce structures that are free standing and electrically isolated. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/246997 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/0259 (20130101) H01L 21/02376 (20130101) H01L 21/02378 (20130101) H01L 21/02381 (20130101) H01L 21/02565 (20130101) H01L 21/02568 (20130101) H01L 21/02612 (20130101) H01L 29/24 (20130101) H01L 29/045 (20130101) H01L 29/0665 (20130101) Original (OR) Class H01L 29/0669 (20130101) H01L 29/785 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258089 | Wan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); University of North Texas (Denton, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Wan (Plano, Texas); Yixin Gu (Austin, Texas); Chenyuan He (Austin, Texas); Songwei Li (Austin, Texas); Mushuang Liu (Austin, Texas); Shengli Fu (Austin, Texas) |
| ABSTRACT | The present disclosure presents aerial communication systems and methods. One such system comprises an unmanned aerial vehicle platform and a communication component integrated with the unmanned aerial vehicle platform, wherein the communication component is configured to establish an Air to Air (A2A) communication channel with a remote directional antenna that is integrated with a remote unmanned aerial vehicle platform. The system further includes a computing component integrated with the unmanned aerial vehicle platform, wherein the computing component is configured to determine an optimal heading angle for transmission of communication signals from a directional antenna to the remote directional antenna in an unknown communication environment from received signal strength indicator (RSSI) information obtained from the remote directional antenna. Other systems and methods are also disclosed. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168973 |
| CURRENT CPC | Transmission H04B 7/043 (20130101) H04B 17/318 (20150115) Original (OR) Class H04B 17/391 (20150115) Wireless Communication Networks H04W 4/46 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258117 | Halepovic et al. |
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| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Emir Halepovic (Somerset, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Hulya Seferoglu (Chicago, Illinois); Muhammad Usama Chaudhry (Milpitas, California); Shibin Mathew (Chicago, Illinois); Shanyu Zhou (Chicago, Illinois); Balajee Vamanan (Chicago, Illinois) |
| ABSTRACT | Concepts and technologies directed to agile transport for background traffic in cellular networks are disclosed herein. In various aspects, a system can include a processor and memory storing instructions that, upon execution, cause performance of operations. The operations can include determining a capacity of a communication path that communicatively couples a user equipment to a radio access network cell site. The operations can include identifying, from the radio access network cell site, a queue that is constructed for the user equipment. The operations can include assembling a plurality of probe burst packet sets from a background traffic flow. The operations can include probing the communication path for spare capacity using the plurality of probe burst packet sets and delivering the background traffic flow to the user equipment using the spare capacity while the communication path is not busy. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/101015 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0048 (20130101) Original (OR) Class H04L 67/28 (20130101) Wireless Communication Networks H04W 72/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258531 | Gruev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viktor Gruev (Urbana, Illinois); Missael Garcia (Urbana, Illinois) |
| ABSTRACT | A polarization imager is provided that includes a plurality of CMOS photodetectors and a plurality of polarization filters. Each of the plurality of CMOS photodetectors has a photodiode that is configured to operate in forward bias mode. Further, each of the plurality of polarization filters is monolithically integrated with a corresponding one of the plurality of CMOS photodetectors. Each of the plurality of photodiodes exhibits a logarithmic response to a flux of incident photons. The polarization imager achieves a dynamic range of at least 100 decibels with a signal-to-noise ratio of at least 60 decibels. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 16/585711 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14625 (20130101) H01L 27/14643 (20130101) Pictorial Communication, e.g Television H04N 5/37455 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258725 | Shoari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arian Shoari (San Diego, California); Mona Komeijani (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arian Shoari (San Diego, California); Mona Komeijani (San Diego, California) |
| ABSTRACT | This disclosure describes novel schemes and utilities that promote sustainable usage of smartphones. It describes apparatus and methods to prevent phone loss, prevent overheating problems, decrease energy waste of the battery, prevent overcharging, decrease packaging waste, and encourage sustainable behavior among users to increase the life of the electronic product. In addition, this application characterize mechanism for localization of people and objects. The apparatus and methods may be applied to promote sustainable usage of other electronic devices such as tablets, laptops, pocket PCs, personal digital assistants (PDAs), e-readers, wearable devices, and etc. In addition, a framework has been presented which can be applied to promote sustainable behavior for any consumer electronics products including smartphones. In addition, novel localization apparatus and methods is presented in this application that can be applied for general localization/tracking purposes. |
| FILED | Tuesday, February 09, 2021 |
| APPL NO | 17/172070 |
| CURRENT CPC | Transmission H04B 17/27 (20150115) Wireless Communication Networks H04W 4/023 (20130101) Original (OR) Class H04W 52/0229 (20130101) H04W 68/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210251560 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KNOW BIOLOGICAL, INC. (Milton, Georgia); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary Stephen Arnold (Cumming, Georgia); Matthew Wallace Moorman (Albuquerque, New Mexico); Joshua Jonathan Whiting (Albuquerque, New Mexico) |
| ABSTRACT | A method of detecting a seizure includes collecting volatile organic compounds with a collector material of a collector; separating a mixture of the volatile organic compounds into its constituent chemicals with a gas chromatography column; ionizing the constituent chemicals to create ionized chemicals and detecting the ionized chemicals; and analyzing the ionized chemicals to identify seizure-indicative volatile organic compounds. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308145 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/443 (20130101) A61B 5/4094 (20130101) Original (OR) Class A61B 5/6831 (20130101) A61B 5/6833 (20130101) A61B 10/00 (20130101) A61B 2010/0083 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/00 (20130101) G01N 30/20 (20130101) G01N 30/64 (20130101) G01N 30/80 (20130101) G01N 2030/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252189 | DECKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); New Vision BioLOGIC, Inc. (Aurora, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. DECKER (Berthoud, Colorado); Peter N. CIESIELSKI (Arvada, Colorado); Chad J. RONHOLDT (Aurora, Colorado) |
| ABSTRACT | Formulations of cellulose nanofiber useful for osteoinduction are provided. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269422 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/3608 (20130101) A61L 27/3847 (20130101) A61L 2300/102 (20130101) A61L 2300/406 (20130101) A61L 2300/414 (20130101) A61L 2300/428 (20130101) A61L 2400/12 (20130101) A61L 2430/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252487 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Rongyue Wang (Naperville, Illinois); Vojislav Stamenkovic (Naperville, Illinois); Gregory K. Krumdick (Homer Glen, Illinois); Krzysztof Pupek (Plainfield, Illinois) |
| ABSTRACT | A process for synthesis of PtNi high surface area core/shell particles. The processing including formation of PtNi nanoparticles, exposure of the PtNi nanoparticles to oxygen to form a nickel oxide coating on the nanoparticles at the same time the segregation of Ni to surface induces a Pt-skin with PtNi core structure, removal of the nickel oxide coating to form PtNi core/Pt shell (or Pt-skin) structure. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161114 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/42 (20130101) B01J 23/892 (20130101) Original (OR) Class B01J 35/0013 (20130101) B01J 37/04 (20130101) B01J 37/06 (20130101) B01J 37/009 (20130101) B01J 37/14 (20130101) B01J 37/031 (20130101) B01J 37/0072 (20130101) B01J 37/343 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252510 | Schaffer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | In one aspect of the invention, the fluidic device includes a fluidic chip includes a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269349 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252593 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Rongyue Wang (Naperville, Illinois); Krzysztof Pupek (Plainfield, Illinois); Vojislav Stamenkovic (Naperville, Illinois) |
| ABSTRACT | A method for synthesis of PtNi smooth surface core/shell particles or Nano cages and porous nanocages from segregated nanoparticles. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161138 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/892 (20130101) B01J 35/006 (20130101) B01J 35/026 (20130101) B01J 37/14 (20130101) B01J 37/031 (20130101) B01J 37/0201 (20130101) B01J 37/0215 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0018 (20130101) B22F 1/025 (20130101) Original (OR) Class B22F 9/04 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253429 | Iftime et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California); United States of America as Represented by the Administrator of the NASA (Washington, District of Columbia); Bay Systems Consulting, Inc. (Mountain View, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California); United States of America as Represented by the Administrator of the NASA (Washington, District of Columbia); Bay Systems Consulting, Inc. (Mountain View, California) |
| INVENTOR(S) | Gabriel Iftime (Dublin, California); Beomseok Kim (Hayward, California); Clinton J. Smith (San Francisco, California); Eric D. Cocker (Redwood City, California); Junhua Wei (Mountain View, California); David Eric Schwartz (Concord, Massachusetts); Meyya Meyyappan (Pacifica, California); Rahul Pandey (San Jose, California); Yong Zhang (Millbrae, California) |
| ABSTRACT | Disclosed are methods and systems of providing carbon nanotubes decorated with polymer coated metal nanoparticles. Then, annealing the metal coated carbon nanotubes to reduce a quantity of hydrophilic components of the polymer coating. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/235825 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/168 (20170801) Original (OR) Class C01B 32/176 (20170801) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/12 (20130101) G01N 33/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253440 | DAEMEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luc L. DAEMEN (Oak Ridge, Tennessee); Robert L. SACCI (Oak Ridge, Tennessee); Beth L. ARMSTRONG (Oak Ridge, Tennessee); Nathan KIDDER (Oak Ridge, Tennessee) |
| ABSTRACT | A method of preparing a lithium-ion conducting garnet via low-temperature solid-state synthesis is disclosed. The lithium-ion conducting garnet comprises a substantially phase pure aluminum-doped cubic lithium lanthanum zirconate (Li7La3Zr2O14). The method includes preparing nanoparticles comprising lanthanum zirconate (La2Zr2O7-np) via pyrolysis-mediated reaction of lanthanum nitrate (La(NO3)3) and zirconium nitrate (Zr(NO3)4). The method also includes pyrolyzing a solid-state mixture comprising the La2Zr2O7-np, lithium nitrate (LiNO3), and aluminum nitrate (Al(NO3)3) to give the Li7La3Zr2O14 and thereby prepare the lithium-ion conducting garnet. A lithium-ion conducting garnet prepared via the method is also disclosed. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157286 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/02 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0562 (20130101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253515 | KARP et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric M. KARP (Denver, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); Derek Richard VARDON (Lakewood, Colorado); Todd R. EATON (Denver, Colorado) |
| ABSTRACT | An aspect of the present disclosure is a method that includes a first reacting a molecule from at least one of a carboxylic acid, an ester of a carboxylic acid, and/or an anhydride with ammonia to form a nitrile, where the first reacting is catalyzed using an acid catalyst. In some embodiments of the present disclosure, the molecule may include at least one of acetic acid, lactic acid, and/or 3-hydroxyproprionic acid (3-HPA). In some embodiments of the present disclosure, the molecule may include at least one of methyl acetate, ethyl lactate, and/or ethyl 3-hydroxypropanoate (ethyl 3-HP). In some embodiments of the present disclosure, the anhydride may be acetic anhydride. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/239064 |
| CURRENT CPC | Separation B01D 3/009 (20130101) B01D 15/08 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/063 (20130101) Acyclic or Carbocyclic Compounds C07C 253/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253516 | KARP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric M. KARP (Denver, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); Derek Richard VARDON (Lakewood, Colorado); Todd R. EATON (Denver, Colorado) |
| ABSTRACT | An aspect of the present disclosure is a method that includes a first reacting a molecule from at least one of a carboxylic acid, an ester of a carboxylic acid, and/or an anhydride with ammonia to form a nitrile, where the first reacting is catalyzed using an acid catalyst. In some embodiments of the present disclosure, the molecule may include at least one of acetic acid, lactic acid, and/or 3-hydroxyproprionic acid (3-HPA). In some embodiments of the present disclosure, the molecule may include at least one of methyl acetate, ethyl lactate, and/or ethyl 3-hydroxypropanoate (ethyl 3-HP). In some embodiments of the present disclosure, the anhydride may be acetic anhydride. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244172 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 21/08 (20130101) B01J 23/20 (20130101) B01J 27/16 (20130101) Acyclic or Carbocyclic Compounds C07C 253/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253820 | Smalyukh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ivan I. Smalyukh (Boulder, Colorado); Andrew Johnston Hess (Louisville, Colorado); Quingkun Liu (Boulder, Colorado); Joshua A. De La Cruz (Denver, Colorado); Blaise Fleury (Boulder, Colorado); Eldho Abraham (Boulder, Colorado); Bohdan Senyuk (Boulder, Colorado); Vladyslav Cherpak (Westminster, Colorado) |
| ABSTRACT | Disclosed are cellulose-based 5 flexible aerogels and xerogels containing bacterial cellulose nanorods, ribbons, fibers, and the like, wherein the gels have tunable optical, heat transfer, and stiffness properties. Further disclosed are highly transparent and flexible cellulose nanofiber-polysiloxane composite aerogels featuring enhanced mechanical robustness, tunable optical anisotropy, and low thermal conductivity. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 17/251694 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 9/28 (20130101) Original (OR) Class C08J 2201/026 (20130101) C08J 2201/0504 (20130101) C08J 2205/026 (20130101) C08J 2205/028 (20130101) C08J 2301/02 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/544 (20130101) C08K 7/02 (20130101) C08K 2201/011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253852 | Carroll et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wildcat Discovery Technologies, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyler Carroll (Cardiff, California); Deidre Strand (San Diego, California); Gang Cheng (San Diego, California); Cam Peebles (Oceanside, California); Ben Lancia (La Mesa, California); Cory O'Neill (San Diego, California); Bin Li (San Diego, California); Alex Freigang (San Diego, California) |
| ABSTRACT | A composite solid state electrolyte comprises a polymer electrolyte material, a ceramic ion conductor, and a functionalized coupling agent selected to be compatible with the ceramic ion conductor and the bulk polymer compound. The polymer electrolyte material comprises a bulk polymer compound and a lithium salt. The functionalized coupling agent has a backbone that is structurally similar to the bulk polymer compound. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306921 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/206 (20200101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 14/22 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/08 (20130101) Compositions of Macromolecular Compounds C08L 71/02 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/056 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 10/0565 (20130101) H01M 2300/0065 (20130101) H01M 2300/0068 (20130101) H01M 2300/0082 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253876 | Zalich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Andrew Zalich (Wexford, Pennsylvania); Michael F. Baxter (New Kensington, Pennsylvania); Paul H. Berdahl (Walnut Creek, California); Stuart D. Hellring (Pittsburgh, Pennsylvania); Jeffrey Lynn Stalker (Wexford, Pennsylvania) |
| ABSTRACT | The present invention provides for a composition comprising a pigment, wherein the composition is suitable for coating a surface that is, or is expected to be, exposed to the sun. The pigment comprises particles that fluoresce in sunlight, thereby remaining cooler in the sun than coatings pigmented with non-fluorescent particles. The particles comprise solids that fluoresce or glow in the visible or near infrared (NIR) spectra, or that fluoresce when doped. Suitable dopants include, but are not limited to, ions of rare earths and transition metals. A coating composition includes: (i) a film-forming resin; (ii) an infrared reflective pigment; and (iii) an infrared fluorescent pigment different from the infrared reflective pigment. When the coating composition is cured to form a coating and exposed to radiation comprising fluorescence-exciting radiation, the coating has a greater effective solar reflectance (ESR) compared to the same coating exposed to the radiation comprising fluorescence-exciting radiation except without the infrared fluorescent pigment. A multi-layer coating including the coating composition, and a substrate at least partially coated with the coating composition is also disclosed. A method of reducing temperature of an article includes applying the coating composition to at least a portion of the article. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162284 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 3/06 (20130101) B05D 5/06 (20130101) B05D 7/14 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/004 (20130101) C09D 5/22 (20130101) Original (OR) Class C09D 5/32 (20130101) C09D 5/38 (20130101) C09D 7/61 (20180101) C09D 7/62 (20180101) C09D 127/16 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/54 (20130101) C09K 11/562 (20130101) C09K 11/685 (20130101) C09K 11/883 (20130101) C09K 11/7704 (20130101) C09K 11/7706 (20130101) C09K 11/7772 (20130101) C09K 11/7774 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253952 | Rutstrom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Joseph Rutstrom (Knoxville, Tennessee); Luis Stand (Knoxville, Tennessee); Merry A. Koschan (Knoxville, Tennessee); Mariya Zhuravleva (Knoxville, Tennessee); Charles L. Melcher (Oak Ridge, Tennessee) |
| ABSTRACT | Inorganic halides (e.g., inorganic halide scintillators) of the general formula A3B2X9, including inorganic halides comprising thallium monovalent cations and/or combinations of different halides, are described. Radiation detectors including the inorganic halide scintillators and methods of using the detectors to detect high energy radiation are also described. In some cases, the scintillators can include a gadolinium cation, a boron cation, a lithium cation, a chloride ion, or combinations thereof and the scintillator can be used to detect neutrons. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/156124 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/36 (20200101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/54 (20130101) C01P 2002/72 (20130101) C01P 2002/88 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7773 (20130101) Original (OR) Class Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/12 (20130101) Measurement of Nuclear or X-radiation G01T 1/2018 (20130101) G01T 3/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254048 | Mutalik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivek K. Mutalik (Albany, California); Denish Piya (El Cerrito, California); Adam P. Arkin (San Francisco, California) |
| ABSTRACT | The present invention provides for a nucleic acid encoding a bacteriophage genome comprising a unique n-mer barcode inserted in a non-essential location or gene location within the bacteriophage genome, or a bacteriophage comprising the nucleic acid thereof |
| FILED | Saturday, February 06, 2021 |
| APPL NO | 17/169442 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/1065 (20130101) Original (OR) Class C12N 2795/00022 (20130101) C12N 2795/00033 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254070 | SCHULMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (BALTIMORE, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | REBECCA B. SCHULMAN (BALTIMORE, Maryland); DOMINIC SCALISE (BALTIMORE, Maryland) |
| ABSTRACT | The present disclosure provides systems, compositions, and methods related to oligonucleotide buffers for use in generating molecular circuits and their application to DNA nanostructure formation and growth. In particular, the present disclosure provides materials and methods for modulating polynucleotide concentrations using DNA strand-displacement to control molecular reactions for various applications, such as drug delivery, RNA-based therapeutics, chemical synthesis, and nanostructure assembly. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/271549 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254077 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Scott E. Baker (Richland, Washington); Jon K. Magnuson (Richland, Washington); Morgann C. Reilly (Cambridge, Massachusetts); Joonhoon Kim (Berkeley, California); John Gladden (Alameda, California); Jed J. Lynn (Fleming Island, Florida) |
| ABSTRACT | Fungi that are genetically inactivated for the mstC gene (or a homolog thereof) are provided, which can also be genetically modified to increase production of heterologous proteins from a glucoamylase promoter. Methods of using these fungi, for example to degrade a biomass, are also provided. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161502 |
| CURRENT CPC | Peptides C07K 14/37 (20130101) C07K 14/38 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/145 (20210501) C12N 9/20 (20130101) C12N 9/50 (20130101) C12N 9/2402 (20130101) C12N 9/2428 (20130101) C12N 9/2437 (20130101) C12N 9/2445 (20130101) C12N 15/52 (20130101) Original (OR) Class C12N 15/80 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/685 (20210501) Enzymes C12Y 301/01001 (20130101) C12Y 301/01003 (20130101) C12Y 302/0102 (20130101) C12Y 302/01003 (20130101) C12Y 302/01021 (20130101) C12Y 302/01176 (20130101) C12Y 304/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254092 | Lofstedt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jan Christer Lofstedt (Lund, Sweden); Per Fredrik Hofvander (Bjarred, Sweden); Honglei Wang (Lund, Sweden); Baojian Ding (Lund, Sweden); Yihan Xia (Lund, Sweden); Carin Ingegerd Jarl-Sunesson (Lund, Sweden); Board of Regents of the University of Nebraska (Lincoln, Nebraska); ISCA Technologies, Inc. (Riverside, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jan Christer Lofstedt (Lund, Sweden); Per Fredrik Hofvander (Bjarred, Sweden); Baojian Ding (Lund, Sweden); Yihan Xia (Lund, Sweden); Honglei Wang (Lund, Sweden); Carin Ingegerd Jarl-Sunesson (Lund, Sweden); Edgar Benjamin Cahoon (Lincoln, Nebraska); Agenor Mafra-Neto (Riverside, California) |
| ABSTRACT | The present disclosure relates to methods of producing insect pheromone precursors and genetically modified plants capable of producing insect pheromone precursors. The genetically modified plants include a heterologous gene encoding at least one silencing suppressor protein and at least one enzyme selected from the group consisting of a fatty acyl desaturase, a fatty acyl elongase, a fatty acyl reductase, and an acyl-CoA oxidase. |
| FILED | Saturday, February 06, 2021 |
| APPL NO | 17/169444 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8247 (20130101) C12N 15/8286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254209 | Elam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Jeffrey W. Elam (Elmhurst, Illinois); Anil U. Mane (Naperville, Illinois); Maximillian Gebhard (Westmont, Illinois) |
| ABSTRACT | A secondary electron emissive coating. The coating is formed by atomic layer deposition of CaF2 on a substrate by ALD half cycle exposure of an alkaline metal amidinate and ALD half cycle exposure of a fluorinated compound, where the deposition occurs at a reaction temperature greater than a highest sublimation temperature of the first metal precursor and the second metal precursor and less than 50° C. above the highest sublimation temperature. |
| FILED | Thursday, February 13, 2020 |
| APPL NO | 16/790559 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/30 (20130101) Original (OR) Class C23C 16/4408 (20130101) C23C 16/45527 (20130101) C23C 16/45553 (20130101) C23C 16/45555 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254478 | Chakrabarti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suryarghya Chakrabarti (Niskayuna, New York); Jing Li (Niskayuna, New York) |
| ABSTRACT | A turbine damper may be provided that may include an elongated body sized to fit inside a turbine blade, the elongated body elongated along a radial direction of the turbine blade relative to a rotation axis of the turbine blade, and plural dampening masses coupled with the elongated body and disposed at different locations along the radial direction. The plural dampening masses may be one or more of sized to dampen different vibration modes of the turbine blade, or moveable relative to and along the elongated body in the radial direction. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 16/794732 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/26 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/30 (20130101) F05D 2260/96 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254563 | FLOWERS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel L. FLOWERS (San Leandro, California) |
| ABSTRACT | The present disclosure relates to a system for controlling ignition of an air/fuel mixture intake charge directed into an internal combustion engine. The system may have a longitudinally movable inner cylinder liner configured to fit within a cylinder wall portion of an internal combustion engine, and able to receive a piston of the engine therein. A portion of the inner cylinder liner defines an internal volume forming a combustion chamber, and the internal volume controls a compression ratio of the cylinder. The system also has a cylinder head assembly operatively associated with the inner cylinder liner and able to move linearly to cause longitudinal displacement of the inner cylinder liner relative to the cylinder wall portion. This enables the volume of the combustion chamber to be further varied, to thus further vary the compression ratio. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168933 |
| CURRENT CPC | Internal-combustion Piston Engines; Combustion Engines in General F02B 75/041 (20130101) Controlling Combustion Engines F02D 15/04 (20130101) Original (OR) Class F02D 35/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254861 | Ho et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); The Australian National University (Acton, Australia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clifford K. Ho (Albuquerque, New Mexico); Joshua Mark Christian (Albuquerque, New Mexico); John Downing Pye (Acton, Australia); Jesus Daniel Ortega (Albuquerque, New Mexico) |
| ABSTRACT | Solar receivers including a plurality of multi-scale solar absorbing surfaces arranged such that light or heat reflected from or emitted from one or more of the plurality of solar absorbing surfaces impinges one or more other solar absorbing surfaces of the solar receiver. The disclosed receivers increase the amount of absorbed energy from a concentrated light source, such as a heliostat field, and reduce radiative and convective heat losses. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165155 |
| CURRENT CPC | Solar Heat Collectors; Solar Heat Systems F24S 10/72 (20180501) Original (OR) Class F24S 30/422 (20180501) F24S 2010/71 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255248 | Christophersen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jon P. Christophersen (Moscow, Idaho); John L. Morrison (Butte, Montana); William H. Morrison (Butte, Montana) |
| ABSTRACT | Impedance testing devices, circuits, systems, and related methods are disclosed. A method may include exciting a device coupled to a load, and capturing a response of the device. The method may further include adjusting the response based on an estimated load response of the device, and estimating an impedance of the device based on the adjusted response. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/301557 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/389 (20190101) Original (OR) Class G01R 31/392 (20190101) G01R 31/3648 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/482 (20130101) H01M 2220/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255257 | NOVOSAD et al. |
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| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Valentine NOVOSAD (Lemont, Illinois); Elena A. ROZHKOVA (Lemont, Illinois); Maxim NIKITIN (Lemont, Illinois); Petr NIKITIN (Lemont, Illinois) |
| ABSTRACT | A significant enhancement of detection capabilities of the room temperature MPQ is seen using optical lithography-defined, ferromagnetic iron-nickel alloy microdisks. Irreversible transitions between strongly non-collinear (vortex) and a collinear single domain states, driven by an ac magnetic field, translate into a nonlinear magnetic response that enables ultrasensitive detection of material at relatively small magnetic fields. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/156796 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0515 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/1806 (20130101) A61K 49/1818 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/1269 (20130101) Original (OR) Class G01R 33/1276 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255297 | Tedeschi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Jonathan R. Tedeschi (Richland, Washington); A. Mark Jones (West Richland, Washington) |
| ABSTRACT | A shared aperture antenna array including an array of antennas is disclosed. Elements of neighboring antennas are shared to create additional antennas. The shared elements include radiating patches and apertures. Each antenna shares an aperture with neighboring antennas. The array of antennas may be linear or two-dimensional. A phase shifting network with single-pole-single-throw reflective switches may be coupled to the antennas. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169344 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/03 (20130101) G01S 13/02 (20130101) Original (OR) Class G01S 2013/0254 (20130101) Antennas, i.e Radio Aerials H01Q 9/285 (20130101) H01Q 9/0435 (20130101) H01Q 21/0006 (20130101) H01Q 21/24 (20130101) H01Q 21/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255891 | Henretty et al. |
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| FUNDED BY |
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| APPLICANT(S) | Reservoir Labs, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Henretty (Brooklyn, New York); Richard A. Lethin (New York, New York); Benoit J. Meister (New York, New York); Nicolas T. Vasilache (New York, New York); David E. Wohlford (Portland, Oregon) |
| ABSTRACT | In a system for automatic generation of event-driven, tuple-space based programs from a sequential specification, a hierarchical mapping solution can target different runtimes relying on event-driven tasks (EDTs). The solution uses loop types to encode short, transitive relations among EDTs that can be evaluated efficiently at runtime. Specifically, permutable loops translate immediately into conservative point-to-point synchronizations of distance one. A runtime-agnostic which can be used to target the transformed code to different runtimes. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 16/791361 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4843 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256103 | Bolme et al. |
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| FUNDED BY |
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| APPLICANT(S) | UT Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David S. Bolme (Oak Ridge, Tennessee); Hector J. Santos Villalobos (Oak Ridge, Tennessee); Aravind K. Mikkilineni (Knoxville, Tennessee) |
| ABSTRACT | A handheld biometric imaging device having an array of cameras configured to simultaneously capture face, iris and fingerprint biometrics of a subject. The device includes a plurality of visible-light cameras and a plurality of infrared-light cameras capable of being triggered simultaneously to obtain a plurality of images from which a 3D image of the light field can be constructed. The device includes a plurality of visible-light illuminators and a plurality of infrared-light illuminators that allow images of a subject to be captured under different lighting profiles. The device may include an onboard control system that is capable of reconstructing a face region, an iris region and a fingerprint region from the 3D light-field image, and then extract a corresponding face template, an iris template, and a fingerprint template from the respective reconstructed regions. The extracted face, iris, and fingerprint templates may be used for enrollment and/or comparison against a biometric-template database associated with one or more watchlists. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162319 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00892 (20130101) G06K 9/00926 (20130101) G06K 9/4661 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256335 | Kaehr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Joseph J. Reczek (New Albany, Ohio); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan James Kaehr (Albuquerque, New Mexico); Joseph J. Reczek (New Albany, Ohio) |
| ABSTRACT | The present invention relates to an optical code including a film of a charge-transfer material, as well as methods thereof. Described herein are optical codes having anisotropic and/or isotropic regions within the film, which can be provided in a pattern that serves as an optical code. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/234959 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/3804 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/133362 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/02 (20130101) G06K 19/022 (20130101) G06K 19/0615 (20130101) Original (OR) Class G06K 19/06037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257205 | Ievlev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton V. Ievlev (Knoxville, Tennessee); Olga D. Ovchinnikova (Knoxville, Tennessee); Matthias Lorenz (Toronto, Canada); Yongtao Liu (Knoxville, Tennessee) |
| ABSTRACT | A method of performing time-of-flight secondary ion mass spectrometry on a sample includes the step of directing a beam of primary ions to the sample, and stimulating the migration of ions within the sample while the beam of primary ions is directed at the sample. The stimulation of the ions is cycled between a stimulation state and a lower stimulation state. Secondary ions emitted from the sample by the beam of primary ions are collected in a time-of-flight mass spectrometer. Time-of-flight secondary ion mass spectrometry is then performed on the secondary ions. A system for performing time-of-flight secondary ion mass spectrometry on a sample is also disclosed. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/174968 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) H01J 49/0031 (20130101) H01J 49/408 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257448 | Sampayan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Opcondys, Inc. (Manteca, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Sampayan (Manteca, California); Kristin Cortella Sampayan (Manteca, California) |
| ABSTRACT | Devices, methods and techniques are disclosed to suppress electrical discharge and breakdown in insulating or encapsulation material(s) applied to solid-state devices. In one example aspect, a multi-layer encapsulation film includes a first layer of a first dielectric material and a second layer of a second dielectric material. An interface between the first layer and the second layer is configured to include molecular bonds to prevent charge carriers from crossing between the first layer and the second layer. The multi-layer encapsulation configuration is structured to allow an electrical contact and a substrate of the solid-state device to be at least partially surrounded by the multi-layer encapsulation configuration. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/177884 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/762 (20130101) H01L 29/0611 (20130101) Original (OR) Class H01L 29/0649 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257463 | Varley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel Basile Varley (Livermore, California); Noah Patrick Allen (Oakland, California); Clint Frye (Livermore, California); Kyoung Eun Kweon (Pleasonton, California); Vincenzo Lordi (Livermore, California); Lars Voss (Livermore, California) |
| ABSTRACT | An apparatus includes a heterostructure including a substrate of Group-III-nitride material, a source layer including a dopant positioned on a surface of the substrate, and a conductive cap layer positioned on the source layer. A method of electric field-enhanced impurity diffusion includes obtaining a heterostructure including a substrate of Group-III-nitride semiconductor material, a source layer including a dopant positioned directly on the substrate, and a conductive cap layer positioned above the source layer, and applying a thermal annealing treatment to the heterostructure. An electric field gradient is established within the source layer and the cap layer for causing diffusion of an element from the substrate to the cap layer, and for causing diffusion of the dopant from the source layer to a former location of the element in the substrate thereby changing a conductivity and/or magnetic characteristic of the substrate. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166962 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/2258 (20130101) H01L 29/45 (20130101) H01L 29/2003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257612 | ARCHER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lynden A. ARCHER (Ithaca, New York); Qing ZHAO (Tianjin, China PRC) |
| ABSTRACT | Provided are passivation layers for batteries. The batteries may be aqueous aluminum batteries. The passivation layer may be disposed on a portion of or all of a surface or surfaces of an anode, which may be an aluminum or aluminum alloy anode. The passivation layer is bonded to the surface of the anode. The passivation layer may be an organic, nitrogen-rich material and inorganic Al-halide rich or Al-nitrate rich material. The passivation layer may be formed by contacting an aluminum or aluminum alloy substrate, which may be aluminum or aluminum alloy anode, with one or more aluminum halide and one or more ionic liquid. |
| FILED | Monday, August 12, 2019 |
| APPL NO | 17/267465 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/48 (20130101) H01M 4/366 (20130101) H01M 4/0426 (20130101) H01M 4/463 (20130101) Original (OR) Class H01M 4/5815 (20130101) H01M 50/44 (20210101) H01M 50/417 (20210101) H01M 50/437 (20210101) H01M 50/491 (20210101) H01M 50/497 (20210101) H01M 2300/0008 (20130101) H01M 2300/0011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257620 | SHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhangxing SHI (Chicago, Illinois); Lu ZHANG (Naperville, Illinois) |
| ABSTRACT | An electrode for a lithium-ion electrochemical cell comprises silicon particles and carbon particles coated on a conductive current collector. The silicon and carbon particles being bound to each other and to the current collector by a cross-linked binder formed from a combination of a poly(carboxylic acid) such as poly(acrylic acid) and a branched polyethyleneimine. A method of preparing the anode also is described. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 16/791651 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/1016 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/364 (20130101) H01M 4/386 (20130101) H01M 4/0404 (20130101) H01M 4/0471 (20130101) H01M 4/587 (20130101) H01M 4/622 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 4/1393 (20130101) H01M 4/1395 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257630 | Forner-Cuenca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Eindhoven University of Technology (Eindhoven, Netherlands) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antoni Forner-Cuenca (Eindhoven, Netherlands); Charles Tai-Chieh Wan (Cambridge, Massachusetts); Remy Richard Jacquemond (Eindhoven, Netherlands); Fikile Richard Brushett (Cambridge, Massachusetts) |
| ABSTRACT | Methods of forming porous electrodes are provided, such porous electrodes, and thus the techniques for forming the same, having beneficial uses in conjunction with redox flow batteries. The methods include the use of phase inversion as part of the fabrication process. In one exemplary embodiment, a polymer solution is immersed in one solvent in conjunction with performing polymer blend casting, and then is subsequently immersed in a second solvent to induce phase inversion. The phase inversion causes two polymers from the polymer solution to separate, leaving one polymer as a standalone porous polymer and the other polymer with the two solvents in which the polymer solution was disposed. Post-treatments can be performed on the porous polymer to form a desired porous electrode configuration. The electrode can be used in a redox flow battery, for example. Various formulation techniques and recipes, along with resulting porous electrode configurations, are also provided. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176796 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/03 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/96 (20130101) Original (OR) Class H01M 4/8817 (20130101) H01M 4/8875 (20130101) H01M 8/188 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257642 | WOOD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VERSA POWER SYSTEMS, LTD (Danbury, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony WOOD (Calgary, Canada); Tahir JOIA (Calgary, Canada) |
| ABSTRACT | The present technology is directed to a solid oxide cell that may be used as a solid oxide fuel cell or a solid oxide electrolyser cell. The solid oxide cell is configured to avoid deformation caused by differential shrinking via incorporation of an oxygen barrier layer which mitigates the damage caused by the introduction of an oxidizing environment in the anode cavity during the operation of the solid oxide cell as a solid oxide fuel cell. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184172 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9025 (20130101) H01M 4/9066 (20130101) H01M 8/1213 (20130101) Original (OR) Class H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257658 | WACHSMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| INVENTOR(S) | Eric D. WACHSMAN (Fulton, Maryland); Liangbing HU (Hyattsville, Maryland); Chunsheng WANG (Silver Spring, Maryland); Yang WEN (Hyattsville, Maryland); Kun FU (College Park, Maryland); Fudong HAN (Greenbelt, Maryland); Chengwei WANG (College Park, Maryland); Venkataraman THANGADURAI (Calgary, Canada); Gregory Thomas HITZ (Riverdale Park, Maryland); Dennis MCOWEN (Bowie, Maryland) |
| ABSTRACT | Disclosed is a method of fabricating a battery or battery component having a solid state electrolyte. A scaffold is provided, the scaffold comprising: a dense central layer comprising a dense electrolyte material, the dense central layer having a first surface, and a second surface opposite the first surface; a first porous layer comprising a first porous electrolyte material, the first porous layer disposed on the first surface of the dense central layer, the porous electrolyte material having a first network of pores therein; wherein each of the dense electrolyte material and the first porous electrolyte material are independently selected from garnet materials. Carbon is infiltrated into the first porous layer. Sulfur is also infiltrated into the first porous layer. The battery component may be used in a variety of battery configurations. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184500 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/625 (20130101) H01M 10/058 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2004/027 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257685 | BELHAROUAK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilias BELHAROUAK (Oak Ridge, Tennessee); Yaocai BAI (Oak Ridge, Tennessee); Jianlin LI (Oak Ridge, Tennessee) |
| ABSTRACT | A method of recycling lithium-ion batteries is disclosed. The method includes isolating a composite electrode that comprises an electrode material adhered to a current collector with a polyvinylidene difluoride (PVDF) binder from a spent lithium-ion battery. The method also includes contacting the composite electrode in a polyol fluid capable of releasing the PVDF binder from the current collector without substantially altering either component. The composite electrode may be a cathode or an anode. The method also includes rapidly delaminating the electrode material from the current collector to give a free electrode material and a free current collector, and recovering each of the free electrode material and the free current collector from the mixture. The free electrode material may be reused to prepare another composite electrode, as well as a lithium-ion battery comprising the same, which are also disclosed. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/177120 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257798 | Power et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik P. Power (Rochester, New York); Jake Bromage (Rochester, New York); Jonathan D. Zuegel (Rochester, New York) |
| ABSTRACT | Integrated active cooling of high-power reflective or diffractive optics uses substrates manufactured from low-expansion ceramics to flow coolant between the back surface of the substrate and chambers behind but adjacent a reflective front surface, in a direction transverse to the front surface, to thereby achieve much greater average power handling than known cooling techniques. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167724 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0401 (20130101) H01S 3/0407 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257880 | Vacca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Andrea Vacca (Lafayette, Indiana); Thomas Ransegnola (West Lafayette, Indiana); Federico Zappaterra (West Lafayette, Indiana); Scott David Sudhoff (West Lafayette, Indiana); Robert R Swanson (Lafayette, Indiana); Enrique Busquets (Fountain Inn, South Carolina) |
| ABSTRACT | An integrated electromechanical and hydraulic system is disclosed which includes an electric machine, the electric machine includes a casing, a stator adapted to remain stationary within the casing, one or more electrically insulated windings coupled to the stator, a rotor separated from the stator and the one or more windings by a radial diamagnetic gap, electrical power couplings, and a first mechanical power couplings, and a hydraulic machine also disposed in the housing, the hydraulic machine having hydro-mechanical couplings as well as a second mechanical power couplings, wherein the second mechanical power couplings are coupled to the first mechanical power couplings. |
| FILED | Saturday, January 30, 2021 |
| APPL NO | 17/163407 |
| CURRENT CPC | Non-positive-displacement Pumps F04D 25/0653 (20130101) Dynamo-electric Machines H02K 1/274 (20130101) H02K 5/207 (20210101) H02K 7/003 (20130101) Original (OR) Class H02K 9/06 (20130101) H02K 2201/03 (20130101) H02K 2205/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257909 | Roessig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Empower Semiconductor, Inc. (Milpitas, California) |
| ASSIGNEE(S) | Empower Semiconductor, Inc. (Milpitas, California) |
| INVENTOR(S) | Trey Roessig (Oakland, California); Parag Oak (Sunnyvale, California); Shrinivasan Jaganathan (San Jose, California); Narendra Gaddam (Milpitas, California) |
| ABSTRACT | A power conversion device includes: a semiconductor substrate; a plurality of controllers formed on the semiconductor substrate; two or more converter phases formed on the semiconductor substrate; two or more programmable components formed on the semiconductor substrate, each of the programmable components connected to a respective one of the two or more converter phases; and an interconnect circuit formed on the semiconductor substrate. The two or more programmable components are programmable to selectively couple the two or more converter phases to the plurality of controllers via the interconnect circuit. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175466 |
| CURRENT CPC | Systems for Regulating Electric or Magnetic Variables G05F 1/10 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 1/10 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/157 (20130101) Original (OR) Class H02M 3/1584 (20130101) H02M 3/33569 (20130101) Pulse Technique H03K 17/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257996 | Nojima |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eaton Intelligent Power Limited (Dublin 4, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geraldo Nojima (Fort Mill, South Carolina) |
| ABSTRACT | An apparatus includes a plurality of parallel-connected semiconductor switches (e.g., silicon carbide (SiC) metal oxide semiconductor field effect transistors (MOSFETs) or other wide-bandgap semiconductor switches) and a plurality of driver circuits having outputs configured to be coupled to control terminals of respective ones of the plurality of semiconductor switches and configured to drive the parallel-connected semiconductor switches responsive to a common switch state control signal. The driver circuits may have respective different power supplies, which may be adjustable. Respective output resistors may couple respective ones of the driver circuits to respective ones of the semiconductor switches. The output resistors may be adjustable. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 16/795261 |
| CURRENT CPC | Pulse Technique H03K 3/011 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258252 | Olson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Olson (Grapeland, Texas); Darel Neal Emmot (Wellington, Colorado); Nicholas George McDonald (Fort Collins, Colorado); John Kim (Palo Alto, California) |
| ABSTRACT | A switch includes a plurality of ingress ports, a plurality of egress ports, and a plurality of buffers comprising a buffer coupled to each ingress port, egress port pair. An ingress port is to determine a plurality of potential egress ports for a packet. The ingress port is to select an egress port of the plurality of potential egress ports based on congestion of the corresponding buffers coupled to the ingress port and to each of the plurality of potential egress ports. The ingress port is to place the packet into the corresponding buffer coupled to the ingress port and the selected egress port. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/247473 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/24 (20130101) H04L 45/38 (20130101) Original (OR) Class H04L 45/42 (20130101) H04L 47/29 (20130101) H04L 47/52 (20130101) H04L 47/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258558 | TAUBIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel TAUBIN (Providence, Rhode Island); Daniel MORENO (Norwich, Connecticut); Fatih CALAKLI (Isparta, Turkey) |
| ABSTRACT | A system and method to capture the surface geometry a three-dimensional object in a scene using unsynchronized structured lighting is disclosed. The method and system includes a pattern projector configured and arranged to project a sequence of image patterns onto the scene at a pattern frame rate, a camera configured and arranged to capture a sequence of unsynchronized image patterns of the scene at an image capture rate, and a processor configured and arranged to synthesize a sequence of synchronized image frames from the unsynchronized image patterns of the scene. Each of the synchronized image frames corresponds to one image pattern of the sequence of image patterns. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226920 |
| CURRENT CPC | Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 35/02 (20130101) Image Data Processing or Generation, in General G06T 7/521 (20170101) G06T 2207/10028 (20130101) Pictorial Communication, e.g Television H04N 13/167 (20180501) H04N 13/254 (20180501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210252643 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jian Liu (Saratoga, California); Shuang Bai (Saratoga, California) |
| ASSIGNEE(S) | PolarOnyx, Inc. (San Jose, California) |
| INVENTOR(S) | Jian Liu (Saratoga, California); Shuang Bai (Saratoga, California) |
| ABSTRACT | Methods and systems for surface structuring to increase emissivity of one or more samples comprising: generating electromagnetic radiation from a femtosecond fiber laser, wherein the electromagnetic radiation comprises a wavelength, a pulse repetition rate, a pulse width, a pulse energy, and an average power; coupling the electromagnetic radiation from the femtosecond fiber laser to an autofocusing scanner, wherein the autofocusing scanner is configured to scan and focus the electromagnetic radiation onto the one or more samples; and using a computer to adjust the pulse repetition rate and the pulse energy of the femtosecond fiber laser and to control the autofocusing scanner to scan and focus the electromagnetic radiation onto the one or more samples to fabricate micro spikes onto the surface of the one or more samples in order to increase the emissivity of the one or more samples. Other embodiments are described and claimed. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 16/791892 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/352 (20151001) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/094042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252773 | Wegst et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Ulrike G. K. Wegst (Hanover, New Hampshire); Kaiyang Yin (West Lebanon, New Hampshire); Claire Adner (Hanover, New Hampshire); Peyton Weber (Hanover, New Hampshire); Amalie Hildebrandt Brynjulfsson (Hanover, New Hampshire) |
| ABSTRACT | In an aspect, the present disclosure pertains to a method of making a material. Generally, the method includes one or more of the following steps of: (1) placing a mixture having one or more components in a container; and (2) extruding the mixture out of at least one opening of at least one nozzle. In an additional aspect, the present disclosure pertains to a material. In some embodiments, the material includes one or more components. In some embodiments, the one or more components are in the form of a multi-layered structure. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/176058 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/255 (20170801) B29C 64/314 (20170801) B29C 64/393 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2023/22 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/10 (20200101) B33Y 50/02 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253256 | McCARLEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. McCARLEY (Titusville, Florida); Christopher FERGUSON (Cape Canaveral, Florida) |
| ABSTRACT | An adjustable vehicle seat including a seat frame forming a seat back, the seat frame being configured to couple with an aerospace vehicle, and a seat pan coupled to the seat frame, where one or more of the seat frame and the seat pan is configured to couple the seat pan to the seat frame in one of a plurality of positions relative to the seat frame so that an eye position of a seat occupant relative to instrumentation within the aerospace vehicle is decoupled from a size of the seat occupant. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172787 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/386 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/771 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) B33Y 80/00 (20141201) Seats Specially Adapted for Vehicles; Vehicle Passenger Accommodation Not Otherwise Provided for B60N 2/24 (20130101) B60N 2/643 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 11/062 (20141201) B64D 11/064 (20141201) B64D 11/0642 (20141201) B64D 11/0689 (20130101) Original (OR) Class Cosmonautics; Vehicles or Equipment Therefor B64G 1/60 (20130101) B64G 1/62 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4099 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253429 | Iftime et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California); United States of America as Represented by the Administrator of the NASA (Washington, District of Columbia); Bay Systems Consulting, Inc. (Mountain View, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California); United States of America as Represented by the Administrator of the NASA (Washington, District of Columbia); Bay Systems Consulting, Inc. (Mountain View, California) |
| INVENTOR(S) | Gabriel Iftime (Dublin, California); Beomseok Kim (Hayward, California); Clinton J. Smith (San Francisco, California); Eric D. Cocker (Redwood City, California); Junhua Wei (Mountain View, California); David Eric Schwartz (Concord, Massachusetts); Meyya Meyyappan (Pacifica, California); Rahul Pandey (San Jose, California); Yong Zhang (Millbrae, California) |
| ABSTRACT | Disclosed are methods and systems of providing carbon nanotubes decorated with polymer coated metal nanoparticles. Then, annealing the metal coated carbon nanotubes to reduce a quantity of hydrophilic components of the polymer coating. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/235825 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/168 (20170801) Original (OR) Class C01B 32/176 (20170801) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/12 (20130101) G01N 33/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253434 | PEGNA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| ASSIGNEE(S) | FREE FORM FIBERS, LLC (Saratoga Springs, New York) |
| INVENTOR(S) | Joseph PEGNA (Saratoga Springs, New York); John L. SCHNEITER (Cohoes, New York); Kirk L. WILLIAMS (Saratoga Springs, New York); Ramkiran GODUGUCHINTA (Ballston Lake, New York) |
| ABSTRACT | A method and apparatus for forming a plurality of fibers from (e.g., CVD) precursors, including a reactor adapted to grow a plurality of individual fibers; and a plurality of independently controllable lasers, each laser of the plurality of lasers growing a respective fiber. A high performance fiber (HPF) structure, including a plurality of fibers arranged in the structure; a matrix disposed between the fibers; wherein a multilayer coating is provided along the surfaces of at least some of the fibers with an inner layer region having a sheet-like strength; and an outer layer region, having a particle-like strength, such that any cracks propagating toward the outer layer from the matrix propagate along the outer layer and back into the matrix, thereby preventing the cracks from approaching the fibers. A method of forming an interphase in a ceramic matrix composite material having a plurality of SiC fibers, which maximizes toughness by minimizing fiber to fiber bridging, including arranging a plurality of SiC fibers into a preform; selectively removing (e.g., etching) silicon out of the surface of the fibers resulting in a porous carbon layer on the fibers; and replacing the porous carbon layer with an interphase layer (e.g., Boron Nitride), which coats the fibers to thereby minimize fiber to fiber bridging in the preform. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/087092 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/956 (20170801) Original (OR) Class Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/76 (20130101) C04B 35/515 (20130101) C04B 35/565 (20130101) C04B 35/62865 (20130101) C04B 35/62868 (20130101) C04B 35/62873 (20130101) C04B 2235/616 (20130101) C04B 2235/3409 (20130101) C04B 2235/5244 (20130101) C04B 2235/5264 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/08 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/16 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/249964 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253811 | Jiang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng Jiang (Gainesville, Florida); Sin-Yen Leo (Hillsboro, Oregon); Calen Leverant (Gainesville, Florida); Danielle Liu (Nashville, Tennessee); Yin Fang (Gainesville, Florida) |
| ABSTRACT | Described herein are methods and compositions relating to tunable nanoporous coatings. In certain aspects, described herein are methods and compositions wherein a tunable nanoporous coating comprises a tunable nanoporous membrane which transitions from opaque to transparent upon the application of force, and from transparent to opaque after washing with a solvent. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230160 |
| CURRENT CPC | Separation B01D 69/125 (20130101) B01D 71/40 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 22/1006 (20200201) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) Original (OR) Class C08J 7/02 (20130101) Optical Elements, Systems, or Apparatus G02B 1/111 (20130101) G02B 5/0247 (20130101) G02B 5/0268 (20130101) G02B 5/0294 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254699 | Hofmann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Douglas C. Hofmann (Altadena, California); Andrew Kennett (Montrose, California); Kobie T. Boykins (Sunland, California) |
| ABSTRACT | Systems and methods in accordance with embodiments of the invention implement bulk metallic glass-based macroscale gears. In one embodiment, a method of fabricating a bulk metallic glass-based macroscale gear, where at least either the thickness of the gear is greater than 3 mm or the diameter of the gear is greater than 9 mm, includes: obtaining design parameters of the gear to be formed; selecting a bulk metallic glass from which the gear will be formed based on the obtained design parameters, where the selected bulk metallic glass is characterized by a resistance to standard modes of wear and a resistance to brittle fracture such that a gear can be formed from the selected bulk metallic glass that accords with the obtained design parameters; and fabricating the gear from the selected bulk metallic glass that accords with the obtained design parameters. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193573 |
| CURRENT CPC | Alloys C22C 1/02 (20130101) C22C 14/00 (20130101) C22C 30/00 (20130101) C22C 45/10 (20130101) Gearing F16H 55/06 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 29/49462 (20150115) Y10T 74/19 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255144 | Kolb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | South Dakota Board of Regents (Pierre, South Dakota) |
| ASSIGNEE(S) | South Dakota Board of Regents (Pierre, South Dakota) |
| INVENTOR(S) | Lowell Kolb (Rapid City, South Dakota); Charles Tolle (Rapid City, South Dakota); Nathan Williams (Rapid City, South Dakota); Jason Ash (Rapid City, South Dakota) |
| ABSTRACT | A system for determining gas characteristics at high altitudes in embodiments of the present invention may have one or more of the following features: (a) a high-altitude balloon having one or more of the following features: (a) a balloon, (b) a balloonsat operably coupled to the balloon, (c) an air path chamber wherein gas at a high altitude can occupy the air path chamber, (d) a first speaker located on a substrate within the air path chamber, wherein the first speaker takes an electrical signal input and creates a first sound wave, and (e) a second speaker located on the substrate facing opposite of the first speaker located outside of the air path chamber, wherein the second speaker takes the electrical signal and creates a second sound wave. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/246093 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/024 (20130101) G01N 29/036 (20130101) Original (OR) Class G01N 29/2437 (20130101) G01N 2291/014 (20130101) G01N 2291/021 (20130101) G01N 2291/02881 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256425 | HARRIVEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANGELA R. HARRIVEL (POQUOSON, Virginia); CHAD L. STEPHENS (POQUOSON, Virginia); KELLIE D. KENNEDY (POQUOSON, Virginia); ALAN T. POPE (POQUOSON, Virginia) |
| ABSTRACT | Aspects of the present disclosure are directed to devices, systems, and methods for optimized integration of a human operator with a machine for safe and efficient operation. Accordingly, aspects of the present disclosure are directed to systems, methods, and devices which evaluate and determine a cognitive state of an operator, and allocate tasks to either the machine and/or operator based on the cognitive state of the operator, among other factors. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307639 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/18 (20130101) A61B 5/7264 (20130101) Card, Board, or Roulette Games; Indoor Games Using Small Moving Playing Bodies; Video Games; Games Not Otherwise Provided for A63F 13/21 (20140901) A63F 13/42 (20140902) A63F 13/67 (20140902) A63F 13/212 (20140902) Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/015 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257658 | WACHSMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| INVENTOR(S) | Eric D. WACHSMAN (Fulton, Maryland); Liangbing HU (Hyattsville, Maryland); Chunsheng WANG (Silver Spring, Maryland); Yang WEN (Hyattsville, Maryland); Kun FU (College Park, Maryland); Fudong HAN (Greenbelt, Maryland); Chengwei WANG (College Park, Maryland); Venkataraman THANGADURAI (Calgary, Canada); Gregory Thomas HITZ (Riverdale Park, Maryland); Dennis MCOWEN (Bowie, Maryland) |
| ABSTRACT | Disclosed is a method of fabricating a battery or battery component having a solid state electrolyte. A scaffold is provided, the scaffold comprising: a dense central layer comprising a dense electrolyte material, the dense central layer having a first surface, and a second surface opposite the first surface; a first porous layer comprising a first porous electrolyte material, the first porous layer disposed on the first surface of the dense central layer, the porous electrolyte material having a first network of pores therein; wherein each of the dense electrolyte material and the first porous electrolyte material are independently selected from garnet materials. Carbon is infiltrated into the first porous layer. Sulfur is also infiltrated into the first porous layer. The battery component may be used in a variety of battery configurations. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184500 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/625 (20130101) H01M 10/058 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2004/027 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210251969 | Abdallah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut); The Unied States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chadi Abdallah (Fairfield, Connecticut); John Krystal (Woodbridge, Connecticut); Ronald Duman (Guilford, Connecticut); Gerard Sanacora (Guilford, Connecticut) |
| ABSTRACT | The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269470 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0053 (20130101) A61K 31/135 (20130101) A61K 31/436 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/24 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251979 | Cardozo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Cardozo (Bronx, New York); Carlos A. Toro-Chacon (Bronx, New York); Zachary Graham (Birmingham, Alabama); Wei Zhao (Bronx, New York); Juan C. Saez (Vina del Mar, Chile) |
| ABSTRACT | Provided are methods of treating an injury to the nervous system in a subject comprising administering to the subject an effective amount of boldine, a boldine analog, or a pharmaceutically-acceptable salt thereof. Also provided are methods of improving voluntary muscle control and methods of treating neuropathic pain in a subject having an injury to the nervous system. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170821 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252108 | Butler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); U.S. DEPARTMENT OF VETERANS' AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Alistair Butler (St. Louis, Missouri); Susan Farr (St. Louis, Missouri); Clemence Girardet (Paris, France) |
| ABSTRACT | Disclosed are methods and compositions for treating cognitive decline in subjects in need. More specifically, disclosed are methods of administrating exogenous adropin to subjects suffering from, or at risk of, cognitive decline. Also disclosed are subjects who would benefit from such treatment and pharmaceutical acceptable compositions comprising adropin, adropin34-76, and derivatives or variations thereof. |
| FILED | Tuesday, June 04, 2019 |
| APPL NO | 17/054740 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/22 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252313 | XU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen XU (Ann Arbor, Michigan); Clifford Suhyun CHO (Ann Arbor, Michigan) |
| ABSTRACT | Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161498 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253422 | Markoutsa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eleni Markoutsa (Tampa, Florida); Subhra Mohapatra (Tampa, Florida); Shyam Mohapatra (Tampa, Florida) |
| ABSTRACT | This invention provides for a RSV-targeted nanoparticle PMN (RTPMN), combining HR2D anti-fusion peptide, and plasmid encoded siRNA against RSV-NS1 and/or RSV-P gene as a safe, effective and inexpensive anti-RSV prophylaxis and/or therapy. |
| FILED | Tuesday, May 21, 2019 |
| APPL NO | 17/057153 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 45/06 (20130101) A61K 47/544 (20170801) A61K 47/6939 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1131 (20130101) C12N 2310/14 (20130101) C12N 2310/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255198 | Niculescu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS OFFICE OF GENERAL (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America as Represented by the Department of Veterans Affairs Office (Washington, District of Columbia) |
| INVENTOR(S) | Alexander Bogdan Niculescu (Indianapolis, Indiana) |
| ABSTRACT | Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for stress disorders. Also disclosed are new methods of use for drugs and natural compounds repurposed for use in reducing stress severity, as well as for preventing and treating stress disorders. All the above mentioned methods are computer assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. A universal approach in everybody, as well as a personalized approaches by gender, and by diagnosis, are disclosed. |
| FILED | Wednesday, June 05, 2019 |
| APPL NO | 16/973687 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/7004 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210252643 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jian Liu (Saratoga, California); Shuang Bai (Saratoga, California) |
| ASSIGNEE(S) | PolarOnyx, Inc. (San Jose, California) |
| INVENTOR(S) | Jian Liu (Saratoga, California); Shuang Bai (Saratoga, California) |
| ABSTRACT | Methods and systems for surface structuring to increase emissivity of one or more samples comprising: generating electromagnetic radiation from a femtosecond fiber laser, wherein the electromagnetic radiation comprises a wavelength, a pulse repetition rate, a pulse width, a pulse energy, and an average power; coupling the electromagnetic radiation from the femtosecond fiber laser to an autofocusing scanner, wherein the autofocusing scanner is configured to scan and focus the electromagnetic radiation onto the one or more samples; and using a computer to adjust the pulse repetition rate and the pulse energy of the femtosecond fiber laser and to control the autofocusing scanner to scan and focus the electromagnetic radiation onto the one or more samples to fabricate micro spikes onto the surface of the one or more samples in order to increase the emissivity of the one or more samples. Other embodiments are described and claimed. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 16/791892 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/352 (20151001) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/094042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253625 | KAZAKOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RealSeq Biosciences, Inc. (Santa Cruz, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergei A. KAZAKOV (San Jose, California); Sergio BARBERAN-SOLER (Santa Cruz, California); Anne DALLAS (Santa Cruz, California); Brian H. JOHNSTON (Scotts Valley, California) |
| ABSTRACT | Disclosed herein are methods and compositions for the detection of small RNAs in a sample. The methods and compositions disclosed herein may be used for preparing sequencing libraries of the small RNAs, fragments of RNAs and DNAs. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/199968 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) C07H 21/02 (20130101) Original (OR) Class C07H 21/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6855 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253734 | LU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IMCARE BIOTECH, LLC (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanyong LU (Horsham, Pennsylvania); Felix LU (Woodland Hills, California) |
| ABSTRACT | Anti-AS-SPIK antibodies are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to diagnose disorders characterized by the expression of AS-SPIK (e.g., liver cancer). Diagnostic methods and kits comprising the anti-AS-SPIK antibodies are also disclosed. |
| FILED | Wednesday, March 06, 2019 |
| APPL NO | 16/978634 |
| CURRENT CPC | Peptides C07K 16/38 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/32 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/567 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 33/57438 (20130101) G01N 2800/50 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254026 | Clarke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Industrial Microbes, Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Jane Clarke (San Francisco, California); Baolong Zhu (San Diego, California); Derek Lorin Greenfield (Kensington, California); Stephanie Rhianon Jones (Berkeley, California); Noah Charles Helman (El Cerrito, California) |
| ABSTRACT | Methods and compositions for the oxidation of short alkanes by engineered microorganisms expressing enzymes are described, along with methods of use. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149394 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/0073 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) C12P 7/06 (20130101) C12P 7/22 (20130101) Enzymes C12Y 114/13025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256345 | Mars et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Clinc, Inc. (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Mars (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Michael Laurenzano (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan) |
| ABSTRACT | Systems and methods for implementing an artificially intelligent virtual assistant includes collecting a user query; using a competency classification machine learning model to generate a competency label for the user query; using a slot identification machine learning model to segment the text of the query and label each of the slots of the query; generating a slot value for each of the slots of the query; generating a handler for each of the slot values; and using the slot values to: identify an external data source relevant to the user query, fetch user data from the external data source, and apply one or more operations to the query to generate response data; and using the response data, to generate a response to the user query. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231269 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/006 (20130101) Original (OR) Class G06N 3/08 (20130101) G06N 20/00 (20190101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/18 (20130101) G10L 15/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210251228 | Cha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong H. Cha (Hilo, Hawaii); Gregory M. Loeb (Geneva, New York) |
| ABSTRACT | Methods for repelling Drosophila species (e.g., D. suzukii, D. melanogaster) involving treating an object or area with a composition containing a Drosophila species (e.g., D. suzukii, D. melanogaster) repelling effective amount of 2-pentylfuran and optionally a carrier. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/174394 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210251237 | Kinkel |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linda L. Kinkel (Minneapolis, Minnesota) |
| ABSTRACT | The disclosure relates to a systemic platform for developing soil-borne plant pathogen inhibiting microbial consortia. The platform utilizes multivariate computer modelling and multidimensional ecological function balancing (MEFB) nodal analysis to develop microbial consortia, consortia, and inoculants. The disclosure further relates to a prescriptive biocontrol system that will enable farmers to have site-specific agricultural biologics developed for their specific site and crop of interest. |
| FILED | Thursday, July 25, 2019 |
| APPL NO | 17/262541 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/22 (20200101) Original (OR) Class A01N 63/28 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259144 | Simon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | James E. Simon (Princeton, New Jersey); William Reichert (Geneva, Illinois) |
| ABSTRACT | A new and distinct Origanum vulgare cultivar named ‘Eli’ is disclosed, which is characterized by dark green leaves, highly aromatic properties, high carvacrol with white flowers that appear and flower late in the season and about 14 weeks to maturity. |
| FILED | Thursday, February 13, 2020 |
| APPL NO | 16/873159 |
| CURRENT CPC | Plants PLT/258 |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20210252189 | DECKER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); New Vision BioLOGIC, Inc. (Aurora, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. DECKER (Berthoud, Colorado); Peter N. CIESIELSKI (Arvada, Colorado); Chad J. RONHOLDT (Aurora, Colorado) |
| ABSTRACT | Formulations of cellulose nanofiber useful for osteoinduction are provided. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269422 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/3608 (20130101) A61L 27/3847 (20130101) A61L 2300/102 (20130101) A61L 2300/406 (20130101) A61L 2300/414 (20130101) A61L 2300/428 (20130101) A61L 2400/12 (20130101) A61L 2430/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253515 | KARP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric M. KARP (Denver, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); Derek Richard VARDON (Lakewood, Colorado); Todd R. EATON (Denver, Colorado) |
| ABSTRACT | An aspect of the present disclosure is a method that includes a first reacting a molecule from at least one of a carboxylic acid, an ester of a carboxylic acid, and/or an anhydride with ammonia to form a nitrile, where the first reacting is catalyzed using an acid catalyst. In some embodiments of the present disclosure, the molecule may include at least one of acetic acid, lactic acid, and/or 3-hydroxyproprionic acid (3-HPA). In some embodiments of the present disclosure, the molecule may include at least one of methyl acetate, ethyl lactate, and/or ethyl 3-hydroxypropanoate (ethyl 3-HP). In some embodiments of the present disclosure, the anhydride may be acetic anhydride. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/239064 |
| CURRENT CPC | Separation B01D 3/009 (20130101) B01D 15/08 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/063 (20130101) Acyclic or Carbocyclic Compounds C07C 253/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253516 | KARP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric M. KARP (Denver, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); Derek Richard VARDON (Lakewood, Colorado); Todd R. EATON (Denver, Colorado) |
| ABSTRACT | An aspect of the present disclosure is a method that includes a first reacting a molecule from at least one of a carboxylic acid, an ester of a carboxylic acid, and/or an anhydride with ammonia to form a nitrile, where the first reacting is catalyzed using an acid catalyst. In some embodiments of the present disclosure, the molecule may include at least one of acetic acid, lactic acid, and/or 3-hydroxyproprionic acid (3-HPA). In some embodiments of the present disclosure, the molecule may include at least one of methyl acetate, ethyl lactate, and/or ethyl 3-hydroxypropanoate (ethyl 3-HP). In some embodiments of the present disclosure, the anhydride may be acetic anhydride. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244172 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 21/08 (20130101) B01J 23/20 (20130101) B01J 27/16 (20130101) Acyclic or Carbocyclic Compounds C07C 253/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20210253015 | Schwartz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Schwartz (Tucson, Arizona); Amy Longshore (San Diego, California); Erika Thoeny (Evanston, Illinois); Sierra Raney (Blacksburg, Virginia); Michael Nagy (Merrifield, Virginia); Andrew Garcia (Tucson, Arizona) |
| ABSTRACT | Vehicle shelf systems having indicators thereon for improving loading and delivery efficiency. Items are scanned for loading, and the indicators on the vehicle shelves identify where to place the item based on the sequence of the delivery point along the delivery route. A mobile computing device alerts a delivery carrier when the delivery vehicle is in proximity to a delivery point when an item is to be delivered. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308432 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 1/6409 (20130101) B60P 1/6481 (20130101) Original (OR) Class Non-portable Lighting Devices; Systems Thereof; Vehicle Lighting Devices Specially Adapted for Vehicle Exteriors F21S 4/28 (20160101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) G06Q 10/083 (20130101) G06Q 10/087 (20130101) G06Q 50/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256232 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | The present disclosure relates to a system for reading a barcode independently of image resolution or scale of a captured barcode image. In one embodiment, the system includes an optical sensor and a processor. The optical scanner can scan a barcode, including a plurality of bars and spaces, into a scanned image. The processor can convert the scanned image into binary data. The processor can also calculate numbers of ones (1s) between zeros (0s) in the binary data and determine widths of one of i) each of the bars and ii) each of the spaces based on the calculated numbers of ones (1s). The processor can further calculate numbers of zeros (0s) between ones (1s) in the binary data and determine widths of the other one of i) each of the bars and ii) each of the spaces based on the calculated numbers of zeros (0s). |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/174736 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/10722 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210258161 | Bonnell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clayton C. Bonnell (Fairfax, Virginia) |
| ABSTRACT | In some aspects, methods and systems for a digital trust architecture are provided. In some aspects, the architecture includes a user account provisioning process. The provisioning process may make use of in person verifications of some personal information to ensure authenticity of the user information. Once the authenticity of user information is established, an account may be created. The user account may include a user email account, with integrated access to digital certificates linked to the user account. Account creation may also automatically publish the new user's public key in a publicly accessible directory, enabling encrypted email information to be easily sent to the new user. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308857 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/6245 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/006 (20130101) H04L 9/32 (20130101) Original (OR) Class H04L 9/0861 (20130101) H04L 9/3239 (20130101) H04L 9/3247 (20130101) H04L 9/3268 (20130101) H04L 63/123 (20130101) H04L 63/0442 (20130101) H04L 2209/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20210251188 | GILES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Federal Bureau of Investigation (Washington, District of Columbia); Auburn University (Auburn, Alabama) |
| ASSIGNEE(S) | The United States of America as Represented by The Federal Bureau of Investigation, Department of Ju (Washington, District of Columbia); Auburn University (Auburn, Alabama) |
| INVENTOR(S) | Kathleen GILES (Washington, District of Columbia); Thomas Craig ANGLE (Auburn, Alabama); Lowell Paul WAGGONER (Auburn, Alabama); Thomas PASSLER (Auburn, Alabama); Terrence FISCHER (Auburn, Alabama) |
| ABSTRACT | Provided herein are methods of making a training aid for detecting a biohazard, and related devices and methods of using the device, including a canine training aid. The devices are made by positioning a polymer layer in proximity and physically separated from a biological material, so that volatile organic compounds contact and bind or infuse the polymer layer. The device is made render-safe by inactivating the infused polymer layer, such as by heating to a temperature sufficient to inactivate biological agents on or in the analyte-infused polymer layer. The device can be stored in a substantially air-tight configuration for subsequent use in training, such as canine and/or or artificial detectors. |
| FILED | Tuesday, October 27, 2020 |
| APPL NO | 17/081441 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 15/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210253875 | KISAILUS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | David KISAILUS (Riverside, California); Ramya MOHAN (Riverside, California) |
| ABSTRACT | A multimodal coating and method of coating a substrate are disclosed. The coating includes a structural framework: and a medium embedded in the structural framework forming an intumescent coating, the intumescent coating configured to undergo intumescent expansion of an outermost coating of the medium upon heating. |
| FILED | Wednesday, July 10, 2019 |
| APPL NO | 17/259475 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/00 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/002 (20130101) C09D 5/185 (20130101) Original (OR) Class C09D 7/61 (20180101) C09D 7/63 (20180101) C09D 105/00 (20130101) C09D 129/04 (20130101) C09D 133/20 (20130101) C09D 161/06 (20130101) C09D 197/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20210253923 | Shi |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington State University (Pullman, Washington) |
| ASSIGNEE(S) | Washington State University (Pullman, Washington) |
| INVENTOR(S) | Xianming Shi (Pullman, Washington) |
| ABSTRACT | A deicing formulation, comprising a chemically degraded extract derived from biowaste; and a salt is provided. Methods for preventing ice formation or removing ice from a surface by applying the deicing formula made of chemically degraded extract derived from biowaste and a salt to the surface are also provided. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/173080 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 3/185 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210256947 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendy Wenling Lin (Montgomery, Ohio); David Herman (Beavercreek, Ohio); James Duvall Bollacker (Scotia, New York) |
| ABSTRACT | Acoustic cores and methods for forming and for assembling acoustic cores are provided. For example, an acoustic core of a gas turbine engine comprises a first attenuation section having a first plurality of attenuation members and a first mating wall having a planar first mating surface. The first mating wall is integrally formed with at least a portion of the first plurality of attenuation members and defines a portion of a perimeter of the first attenuation section. A method for forming an acoustic core comprises additively manufacturing a first attenuation section of the acoustic core, which comprises a first plurality of attenuation members and a first mating wall that are integrally formed as a single unit. A method for assembling an acoustic core comprises applying an adhesive to mating surfaces of first and second attenuation sections and pressing together the mating surfaces to join the first and second attenuation sections. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 16/791579 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7504 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/06 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/045 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/172 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20210252488 | AL-ABED et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government, as represented by the Administrator of the U.S. EPA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Souhail AL-ABED (Cincinnati, Ohio); John MCKERNAN (Cincinnati, Ohio); Slawomir LOMNICKI (Baton Rouge, Louisiana) |
| ABSTRACT | Catalyst materials comprising iron and palladium are described. Also described are methods for preparing such materials. In addition, methods for remediating materials such as sediments and groundwater using the catalyst materials are described. |
| FILED | Tuesday, February 18, 2020 |
| APPL NO | 16/793538 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) B01J 23/8906 (20130101) Original (OR) Class B01J 35/1061 (20130101) B01J 37/14 (20130101) B01J 37/18 (20130101) B01J 37/0203 (20130101) B01J 37/0213 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/725 (20130101) C02F 2101/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210252510 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | In one aspect of the invention, the fluidic device includes a fluidic chip includes a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269349 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20210255674 | Steely, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon C. Steely, JR. (Hudson, New Hampshire); Richard Dischler (Bolton, Massachusetts); David Bach (Shrewsbury, Massachusetts); Olivier Franza (Brookline, Massachusetts); William J. Butera (Newton, Massachusetts); Christian Karl (Hudson, Massachusetts); Benjamin Keen (Minneapolis, Minnesota); Brian Leung (Quincy, Massachusetts) |
| ABSTRACT | Embodiments herein may present an integrated circuit or a computing system having an integrated circuit, where the integrated circuit includes a physical network layer, a physical computing layer, and a physical memory layer, each having a set of dies, and a die including multiple tiles. The physical network layer further includes one or more signal pathways dynamically configurable between multiple pre-defined interconnect topologies for the multiple tiles, where each topology of the multiple pre-defined interconnect topologies corresponds to a communication pattern related to a workload. At least a tile in the physical computing layer is further arranged to move data to another tile in the physical computing layer or a storage cell of the physical memory layer through the one or more signal pathways in the physical network layer. Other embodiments may be described and/or claimed. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/174106 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/183 (20130101) Original (OR) Class G06F 9/5027 (20130101) G06F 15/76 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/5384 (20130101) H01L 23/5385 (20130101) H01L 23/5386 (20130101) H01L 25/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255910 | Flajslik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Mario Flajslik (Hudson, Massachusetts); James Dinan (Hopkinton, Massachusetts) |
| ABSTRACT | Systems, apparatuses and methods may provide for detecting an outbound communication and identifying a context of the outbound communication. Additionally, a completion status of the outbound communication may be tracked relative to the context. In one example, tracking the completion status includes incrementing a sent messages counter associated with the context in response to the outbound communication, detecting an acknowledgement of the outbound communication based on a network response to the outbound communication, incrementing a received acknowledgements counter associated with the context in response to the acknowledgement, comparing the sent messages counter to the received acknowledgements counter, and triggering a per-context memory ordering operation if the sent messages counter and the received acknowledgements counter have matching values. |
| FILED | Thursday, May 21, 2020 |
| APPL NO | 16/880277 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/52 (20130101) G06F 9/544 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20210252510 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | In one aspect of the invention, the fluidic device includes a fluidic chip includes a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269349 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210255032 | LAL |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Amit LAL (Ithaca, New York) |
| ABSTRACT | A device configured for low-energy ultrasonic 2D Fourier transform analysis, comprising: (i) a first layer comprising an array of piezoelectric pixels; (ii) a second layer comprising an array of piezoelectric pixels; (iii) a third layer, positioned between the first and second layers, comprising a bulk ultrasonic transmission medium; wherein the second layer of array of piezoelectric pixels is in the Fourier plane of an input signal of the first layer array of piezoelectric pixels. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057868 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 11/08 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/46 (20130101) G01N 2291/0426 (20130101) Electric Digital Data Processing G06F 17/142 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/18 (20130101) H01L 41/083 (20130101) Transmission H04B 11/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Central Intelligence Agency (CIA)
| US 20210258306 | Dowd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wickr Inc. (San Francisco, California) |
| ASSIGNEE(S) | Wickr Inc. (San Francisco, California) |
| INVENTOR(S) | Christopher Dowd (Belleville, New Jersey); Christopher Lalonde (Austin, Texas); Thomas Michael Leavy (River Edge, New Jersey); Arjun Bhatnagar (Matawan, New Jersey); Dipakkumar R. Kasabwala (Edison, New Jersey); David Lautz (New York, New York); Matthew Downs (Brooklyn, New York) |
| ABSTRACT | A solution for circumventing censorship is disclosed. A first device connects to a first server hosted in a content delivery network (CDN). The CDN routes the first device's connection request to the first server. The first server responds by providing the first device with a configuration file that contains a plurality of second servers for the first device to access. Accordingly, the first device disconnects from the first server and hops between one or more of the plurality of second servers contained in the configuration file. By distributing the configuration file from a first server hosted in a CDN, the first device is able to obfuscate the true endpoint of the connection. Thus, the first device is able to obtain the configuration file without drawing the ire of censors. By hopping from server-to-server, the first device is able to stay one-step ahead of censors. Accordingly, the present disclosure describes a multi-prong approach to staying a step ahead of eavesdroppers, sniffers, and censors. |
| FILED | Monday, August 13, 2018 |
| APPL NO | 16/102136 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/0813 (20130101) H04L 63/104 (20130101) H04L 63/0823 (20130101) H04L 63/0876 (20130101) Original (OR) Class H04L 67/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20210254052 | Jacobson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gen9, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Gen9, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Joseph Jacobson (Newton, Massachusetts); George M. Church (Brookline, Massachusetts); Larry Li-Yang Chu (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/242178 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2219/0052 (20130101) B01J 2219/0059 (20130101) B01J 2219/00378 (20130101) B01J 2219/00389 (20130101) B01J 2219/00529 (20130101) B01J 2219/00585 (20130101) B01J 2219/00596 (20130101) B01J 2219/00599 (20130101) B01J 2219/00608 (20130101) B01J 2219/00659 (20130101) B01J 2219/00693 (20130101) B01J 2219/00722 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/0268 (20130101) B01L 3/502792 (20130101) B01L 2400/0436 (20130101) B01L 2400/0439 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/66 (20130101) C12N 15/1093 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) C12Q 1/6844 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 20210257743 | Puchades et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ivan Puchades (Honeoye Falls, New York); Brian Landi (Rochester, New York); Ian D. Peterson (Rochester, New York); Rodney S. Sorrell (Melbourne, Florida); Stephen R. Landers (Satellite Beach, Florida); Andrew Bucossi (Rochester, New York) |
| ASSIGNEE(S) | Rochester Institute of Technology (Rochester, New York) |
| INVENTOR(S) | Ivan Puchades (Honeoye Falls, New York); Brian Landi (Rochester, New York); Ian D. Peterson (Rochester, New York); Rodney S. Sorrell (Melbourne, Florida); Stephen R. Landers (Satellite Beach, Florida); Andrew Bucossi (Rochester, New York) |
| ABSTRACT | An electromagnetic reflector composed of a non-knitted, non-metallic carbon-based material mesh, antenna system incorporating the reflector and method for fabrication are disclosed. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/179182 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 15/141 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20210253232 | Benedict et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Moble Benedict (College Station, Texas); David Coleman (Bryan, Texas); Atanu Halder (College Station, Texas); Bochan Lee (College Station, Texas); Andrew Riha (Bryan, Texas); Farid Saemi (Houston, Texas); Carl Runco (College Station, Texas); Vishaal Subramanian (College Station, Texas); Eric Greenwood (Newport News, Virginia); Vinod Lakshminarayan (Sunnyvale, California) |
| ABSTRACT | A hover-capable aircraft includes a body including a tubular strut, a first rotor assembly rotatably coupled to the body and positioned about the strut, wherein the first rotor assembly includes a first plurality of circumferentially-spaced blades, a first actuation assembly including a first plurality of electronically controlled actuators coupled to a first swashplate and configured to control the movement of the first swashplate relative to the body, and a control system coupled to the body and configured to control the first plurality of actuators, wherein the control system includes a cable extending through a passage formed in the tubular strut and in signal communication with the first plurality of actuators. |
| FILED | Friday, June 14, 2019 |
| APPL NO | 17/252502 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 15/20 (20130101) B60L 50/60 (20190201) B60L 2200/10 (20130101) Aeroplanes; Helicopters B64C 27/68 (20130101) Original (OR) Class B64C 27/467 (20130101) B64C 27/605 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 17/80 (20130101) B64D 27/24 (20130101) B64D 31/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210254480 | Behling et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | United Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Weston Behling (Norwalk, Connecticut); Michael C. Weber (Niantic, Connecticut); William B. McLean (East Hampton, Connecticut); William S. Pratt (West Hartford, Connecticut); Joon Ha (Glastonbury, Connecticut) |
| ABSTRACT | A rotor disk assembly for a gas turbine engine includes a rotor disk that defines an axis, the rotor disk comprising a slot within a rim of the disk and a spacer within the slot, the spacer having a clearance feature sized to permit rotation of a rotor blade from an insertion position to an installed position. |
| FILED | Tuesday, February 18, 2020 |
| APPL NO | 16/793307 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/32 (20130101) F01D 5/303 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210257532 | GRANINGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AURELIUS L. GRANINGER (SYKESVILLE, Maryland); JOEL D. STRAND (ELLICOTT CITY, Maryland); MICAH JOHN ATMAN STOUTIMORE (KENSINGTON, Maryland); ZACHARY KYLE KEANE (BALTIMORE, Maryland); JEFFREY DAVID HARTMAN (SEVERN, Maryland); JUSTIN C. HACKLEY (CATONSVILLE, Maryland) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | AURELIUS L. GRANINGER (SYKESVILLE, Maryland); JOEL D. STRAND (ELLICOTT CITY, Maryland); MICAH JOHN ATMAN STOUTIMORE (KENSINGTON, Maryland); ZACHARY KYLE KEANE (BALTIMORE, Maryland); JEFFREY DAVID HARTMAN (SEVERN, Maryland); JUSTIN C. HACKLEY (CATONSVILLE, Maryland) |
| ABSTRACT | Test structures and methods for superconducting bump bond electrical characterization are used to verify the superconductivity of bump bonds that electrically connect two superconducting integrated circuit chips fabricated using a flip-chip process, and can also ascertain the self-inductance of bump bond(s) between chips. The structures and methods leverage a behavioral property of superconducting DC SQUIDs to modulate a critical current upon injection of magnetic flux in the SQUID loop, which behavior is not present when the SQUID is not superconducting, by including bump bond(s) within the loop, which loop is split among chips. The sensitivity of the bump bond superconductivity verification is therefore effectively perfect, independent of any multi-milliohm noise floor that may exist in measurement equipment. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168443 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2884 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 22/12 (20130101) H01L 24/16 (20130101) H01L 24/81 (20130101) H01L 25/0657 (20130101) H01L 27/18 (20130101) H01L 39/06 (20130101) H01L 39/08 (20130101) H01L 39/10 (20130101) H01L 39/12 (20130101) H01L 39/025 (20130101) Original (OR) Class H01L 39/223 (20130101) H01L 2224/13109 (20130101) H01L 2224/16145 (20130101) H01L 2224/81024 (20130101) H01L 2224/81908 (20130101) H01L 2225/06513 (20130101) H01L 2225/06596 (20130101) H01L 2924/1423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, August 19, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page